LOCUS 009_IIG_Bs02_SNP 3873897 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1d1-cvskbt2 VERSION urn.local...1d1-cvskbt2 KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3873787..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" /label="ydgG CDS" gene 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /label="ydgG gene" CDS 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" /label="ydgH CDS" gene 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /label="ydgH gene" downshifts 573224 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" /label="ydgI CDS" gene complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /label="ydgI gene" downshifts complement(573253) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" /label="ydgJ CDS" gene complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /label="ydgJ gene" promotor_-10 complement(574380..574399) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(574395) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(574415..574420) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 574586..574588 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 574604..574623 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 574610..574698 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 574610 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="upshifts" CDS 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" /label="ydgK CDS" gene 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /label="ydgK gene" downshifts 575886 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" /label="ydhB CDS" gene complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /label="ydhB gene" S_feature complement(576681..576819) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(576807..576826) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576819) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576840..576847) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576851..576858 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576872..576891 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576876 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="upshifts" CDS 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" /label="ydhC CDS" gene 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /label="ydhC gene" promotor_-35 577662..577667 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 577683..577701 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 577689 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="upshifts" CDS 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" /label="spoL CDS" gene 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /label="spoL gene" downshifts 578966 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 579064..579071 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579085..579104 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579089 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="upshifts" CDS 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" /label="ydhE CDS" gene 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /label="ydhE gene" downshifts 580352 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" /label="ydhF CDS" gene complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /label="ydhF gene" downshifts complement(580405) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" /label="phoB CDS" gene complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /label="phoB gene" promotor_-10 complement(582600..582617) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582601) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(582603..582671) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(582624..582631) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(582661..582679) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582679) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582695..582700) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 582748..582755 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582769..582788 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582771..582904 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 582771 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="upshifts" CDS 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" /label="fra CDS" gene 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /label="fra gene" downshifts 583255 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(583350) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" /label="ydhH CDS" gene complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /label="ydhH gene" CDS complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" /label="ydhI CDS" gene complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /label="ydhI gene" promotor_-35 584021..584028 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584042..584061 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584046 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(584377..584396) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(584387) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(584411..584414) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" /label="ydhJ CDS" gene 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /label="ydhJ gene" downshifts 585388 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 585435..585441 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585456..585474 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585464 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585500..585507 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 585520 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 585521..585540 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" /label="ydhK CDS" gene 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /label="ydhK gene" downshifts 586154 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" /label="pbuE CDS" gene complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /label="pbuE gene" downshifts complement(586212) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" /label="aswA RNA" gene complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /label="aswA gene" downshifts complement(587445) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(587514..587533) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(587528) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(587549..587553) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 587612..587619 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587633..587652 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587640 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" /label="gmuB CDS" gene 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /label="gmuB gene" CDS 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" /label="gmuA CDS" gene 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /label="gmuA gene" CDS 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" /label="gmuC CDS" gene 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /label="gmuC gene" CDS 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" /label="gmuD CDS" gene 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /label="gmuD gene" S_feature 591086..591172 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 591150..591157 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 591171..591190 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 591174 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" /label="gmuR CDS" gene 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /label="gmuR gene" CDS 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" /label="gmuE CDS" gene 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /label="gmuE gene" CDS 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" /label="gmuF CDS" gene 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /label="gmuF gene" CDS 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" /label="gmuG CDS" gene 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /label="gmuG gene" downshifts 594914 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" /label="ydhUc CDS" gene complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo /label="ydhUc gene" downshifts complement(595031) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(595867..595878) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595875) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(595892..595898) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 595953..595960 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 595974..595993 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 595976..596076 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 595978 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(596024) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 596036 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 596044..596051 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 596065..596084 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 596080..596167 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 596080 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 601536 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 601640..601644 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 601660..601679 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 601664 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 605320 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(605603) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 607266..607285 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 607276 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 607278..607467 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 607432..607439 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 607453..607472 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 607469..607639 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 607469 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(607534..607553) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607546) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607567..607574) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 608626..608726 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 608686 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 609742 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(609817) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 610380..610385 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610400..610418 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 610402 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 610721..610722 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 610732..610746 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 610754 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(610759..610778) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610776..610884 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(610779) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(610792..610797) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 610858..610864 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610878..610897 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610886..610960 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 610886 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 612927..613019 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 612976 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 613021..>614247 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(614247,614254) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 614248..614253 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(614374) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(616855..616874) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616881) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(616888..616895) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 616944..616945 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 616960..617042 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 616960 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 616961..616980 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 619596..619603 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 619617..619636 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 619622 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 620611 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 620751..620760 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 620767 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620773..620788 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 621506..621570 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 624352 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 624396 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(625466..625485) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(625484) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(625499..625505) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 625694..625701 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 625714 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 625716..626018 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 625716..625735 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 627432 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(627488) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 628068..628077 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 628091..628110 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 628092..628627 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 628092 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(628529..628823) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 628628..628647 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 628629..628926 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 628629 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(628818..628832) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(628823) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 628925..628944 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 628928 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 629324 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 630424 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(630500) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(630699..630831) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(630742) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(631074..631093) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(631085) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 631766..631775 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631788..631807 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 631788 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(632806..632824) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632814) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632840..632845) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(632963..632978) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632984) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632990..632999) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(633052) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(634611..634630) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(634625) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(634644..634653) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(634746) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(636182..636201) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636196) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 636472..636479 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636495..636514 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636496 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 637376 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(637651) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 637705..637724 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 637715 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 642149..642156 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 642171..642190 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 642187..642316 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 642187 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 643844 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 643965..643969 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 643985..644004 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 643995 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 644130 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 645539 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 645582 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 645611..645620 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 645631..645771 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 645631 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 645633..645648 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 646560 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 646643..646650 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646664..646683 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646670..646733 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 646670 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 646908 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 646952..646958 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646973..646991 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646976..647062 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 646976 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 647041..647048 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647062..647081 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647064 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 647856 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 647912..647919 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647934..647953 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647936 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 648049..648188 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(650114..650133) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650135) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(650148..650155) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(653062) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 656449..656549 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 657597..657611 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 657606 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(657873..657891) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657880) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657907..657912) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 660978 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(661522..661541) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(661531) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 662819 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(662896) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(663113..663533) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 663180..663185 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 663196 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 663199..663218 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(663518..663529) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663533) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(663543..663549) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 663564 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 664957..664963 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 664975 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 664976..664995 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 666185 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 666327 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(666371) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(667948..667967) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667967) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667982..667988) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 668131..668134 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 668148 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 668151..668170 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(673407..673411) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673411) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 674439..674458 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 674447..674563 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 674447 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(674511) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(674581..674681) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(674621) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 675557 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 675601..676405 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(675633) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(676330..676348) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(676351) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(676364..676369) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(676431) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(677283) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(677286..677299) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(677896..678026) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(678017..678035) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678026) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(678050..678056) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 678157..678160 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 678175..678308 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 678175 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 678177..678196 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 681497 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(681573) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 682190..682195 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 682211..682229 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 682223 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(682401..682475) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 682453..682460 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(682469..682488) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682475 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 682476..682495 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682482) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(682503..682510) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 685677 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 685929..685932 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685947..685966 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685955 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 686925..687179 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 688560..689152 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 689109 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 689154..689454 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 689791..689864 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(692756..692771) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(692771) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(692783..692792) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 694316..694427 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 695577..696766 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(696669) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(697498..697517) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(697505) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(697530..697535) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(699167..699186) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(699177) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 700474..700481 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 700495..700514 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 700496 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 701784 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 701830..701934 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 701901..701908 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 701923..701942 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 701936 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(701991) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 702566..702573 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702587..702606 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702597 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 702690 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 702777..702786 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702800..702819 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702803 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(702807..702825) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702827) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702841..702846) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(702849) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 703279 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 703339..703346 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 703362..703381 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703367 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 703959 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 705419..705424 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 705440..705458 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 705440 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(705462..705476) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(705467) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(705484..705488) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 706564..706642 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 706615..706620 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706635..706654 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706644 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 707197 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 707598..707606 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 707617..707635 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 707623 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 711089 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 711174..711177 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711192..711211 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711199 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 719851..719951 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 719911 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(720449) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(720450..720469) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(720482..720491) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(727733..727751) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(727746) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(727767..727772) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(730943) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(730969..731069) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(731009) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 732273..732278 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 732294..732312 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 732297 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(732969..734660) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 733876..733957 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 734651 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(734705) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 735003 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(735039..735058) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735057) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735073..735080) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(735505..735524) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(735519) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(735537..735543) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(735553..736113) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(735585) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(736096..736115) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(736113) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(736129..736138) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 736201..736208 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 736217 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 736221..736240 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 737129 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 737208..737215 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737229..737248 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737237 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 737501..737508 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737524..737543 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737525 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 738149 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 738193 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 739139 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 739183 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(739757..739776) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(739765) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(739790..739797) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 740987 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(741063) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(742140..742159) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742166) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(742174..742181) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 742189..742195 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742210..742228 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742219 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 745431 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 745494..745499 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745515..745533 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 745536 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 745564..745567 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745584..745603 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 745585..745890 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 745585 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 747809 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 747898..747907 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747917..748045 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 747917 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747921..747940 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(747971) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 750598..750607 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750620..750639 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750623 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 751468..751474 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751489..751508 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751503 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 752735 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 752845 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(752886) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(754152..754171) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754170) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754187..754194) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(754263) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(754964..754983) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(754987) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(755055) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(756467..756486) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(756484) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(756501..756508) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 756586..756593 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 756601 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 756607..756625 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(757461..757480) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(757475) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(757493..757502) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 758983 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 759067..759074 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759088..759107 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759093 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 761007 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 761087..761106 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 761095 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(761148) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761232..761235) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761237) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761253..761254) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 761579 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 761655..761662 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761676..761695 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761688 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 761975 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(763459) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(763985) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 765347..765353 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765368..765379 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765385 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(765567..765586) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765571) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765602..765606) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 765627..765630 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765646..765665 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765649 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 766803 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(767397) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(768427..768446) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768431) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768433..768887) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(768459..768466) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768525..768532 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768546..768565 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 768553..769650 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 768553 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(770145..770164) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(770152) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(770180..770187) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 770206..770213 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 770225..770400 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 770225 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 770228..770247 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 770357 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(770809..772479) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 771908..772401 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 772389..772394 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 772403..775668 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 772403 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 772410..772428 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(773880..773899) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(773892) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(773914..773921) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(775362..775381) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(775383) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(775383) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 775638..775643 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775659..775677 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 775670..776295 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 775670 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 776291..776310 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 776297..776828 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 776297 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(776353..776372) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776360) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776386..776393) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(776789..776901) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(776890..776909) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(776901) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(776921..776928) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 776969..776975 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 776989..777007 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 776989 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(777033) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 777375 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 777420..777500 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 777501..777520 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 777502 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 778827 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 778885..778888 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778903..778922 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778911 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 780387 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 780486..780505 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 780497 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 783733 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 783856..783863 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783876..783895 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 783887..783959 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 783887 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 785258..785264 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 785278..785289 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 785279 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 786087 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 786166..786169 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786184..786203 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786197 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 787322..787653 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(787601..787620) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(787615) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(787635..787642) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(788374) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(788498..788628) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(788614..788632) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 788624..788629 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(788628) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 788639..789703 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 788640 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 788645..788663 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(788648..788653) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(788810..788915) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(789231..789311) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(790090..790109) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790103) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(790105..791241) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(790121..790129) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 790172..790173 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790193..790212 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790196 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(791227..791246) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791241) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(791260..791269) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 791477 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 791587 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(791641) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 792683..792689 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 792705..792723 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 792709..793673 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 792709 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793574..793648) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(793625..793644) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793648) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793650..794172) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(793660..793664) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 793789 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 793790..793809 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(794170..794188) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(794185) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(794204..794209) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 794291..794297 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794312..794330 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794312 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(794348) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(794374..794474) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(794414) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 795763..799129 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(799801..799812) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799804) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799826..799832) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 799861..799868 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799883..799902 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799890 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(799936) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(799962..800062) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(800002) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(801733..801748) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(801740) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(801761..801770) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 803085..803089 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803105..803124 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803108 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 803842 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 803924..803927 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803943..803962 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803952 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 804635 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(804710) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(809112..809131) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(809129) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(809146..809149) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 809256..809262 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809276..809294 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809279 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 809826 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(809870) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 809871..811521 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(811071..811162) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(811222) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(811410..811429) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811424) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(811444..811445) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 811491..811498 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811513..811532 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811523 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 813219..813225 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 813240..813251 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 813258..813414 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 813258 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(813290) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 813389 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(813444) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 814051..814057 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 814073..814091 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 814077..814730 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 814077 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(814639..814658) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814654) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814672..814679) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 814720..814725 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 814732 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 814740..814758 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 815851..815857 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815872..815883 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815876 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 816690 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(816743) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(818746..818765) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818764) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818781..818785) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818793..818800 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818814..818833 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818824 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 819014 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 819078..819084 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 819090 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 819099..819110 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 819925 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(819979) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(820845..820864) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820859) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(820880..820883) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(820947) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(821894..821913) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(821897) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(821929..821932) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 821944..821948 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821962..821981 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821971 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 822866..822978 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 824391 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 824685..824692 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824708..824727 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824714 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 824721..825004 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(825219..825238) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825237) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825253..825256) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 825272..825753 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 825724..825727 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825744..825763 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 825755..826002 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 825755 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 826981..827073 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 827030 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 827114..827120 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827132..827151 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827141 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 828352 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 828524..828542 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 828531 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(830627) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 833213 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 833266..833273 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 833286..833305 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 833294 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 835153..835159 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 835171 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 835174..835185 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 835369 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(835435) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(836259..836351) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 836775..836780 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 836788 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 836795..836813 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 836799..837386 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(839311..839330) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839324) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(839345..839348) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 839555..839574 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 839558 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 840977..840996 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 840979 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(841157..841171) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(841187..841193) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(841187) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 843355 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 843404..843411 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843426..843445 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 843434 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 846985 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 847092..847099 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847113..847132 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847117 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 848431 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(849349) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(849397..849497) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(849437) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 853254 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 853324..853330 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853345..853364 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853363 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 855257 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 857656..857661 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857676..857694 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 857677 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(858700..858774) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(858743) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(859324..859403) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(859392..859411) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859403) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859425..859430) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859526..859529 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859545..859564 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859552 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 860207 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 860343..860348 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860362..860381 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860372 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(860907..861295) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(861295) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(861297..861316) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(861329..861337) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(861559) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(862185..862204) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862197) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862218..862225) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(863411..863430) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(863429) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863445..863452) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 863456..863475 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 863461 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(865612..865630) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(865629) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(865646..865649) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(865717) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(866208..866227) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866224) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866242..866248) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 866269..866276 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866290..866309 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866298 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 868896 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(868954) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 869935..869942 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(869947..869966) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 869957..869976 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 869959..870050 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 869959 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(869964) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869981..869988) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 872061 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 872131..872133 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872149..872168 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872152 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 873087..873094 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 873110..873129 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 873119 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 873735 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(873805) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(874010) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(874013..874024) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(874039..874045) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(874184..874195) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(874186) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(874210..874216) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 875007..875010 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875027..875046 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 875037..875209 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 875037 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(875143..875161) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875157) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(875175..875181) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(876228..876496) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 876310 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 876394..876399 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876415..876434 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876420 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 877657..877891 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(877706) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 877870..877877 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877891..877910 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 877893..877965 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 877893 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(877900..877911) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877910) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877926..877932) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 878224 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 878313..878319 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 878334 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 878335..878353 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 878899..878966 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 878934..878943 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 878955..878970 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 878968 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 880160 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 880220..880226 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880240..880251 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 880248..880312 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 880248 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880270..880289) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(880279) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 880295..880301 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(880303..880304) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 880314..880394 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 880314 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 880316..880334 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(880544) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880549..880553) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(880570..880574) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 881385..881455 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 884010 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(884068) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 884491..884500 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 884513..884532 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 884517 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885018..885165) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 885122..885126 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885142..885161 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885149 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 885155..885232 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(885163..885182) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885165) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885197..885204) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 886179..886183 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886199..886218 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886211 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 886343..886655 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(886604..886615) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886606) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(886629..886635) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 887425..887431 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887446..887457 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887447 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(887454..887468) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(887475) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(887477..887481) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 887729 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(887754) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 887827..887835 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887846..887864 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887848 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 888147 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 888203..888210 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 888224..888243 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 888233..888307 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 888233 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 888829 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 890655 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(890756) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(891807..891897) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(891895..891914) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891904) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891929..891936) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(892029) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(893343..893362) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(893362) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(893364..894075) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(893374..893379) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 893408..893415 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 893429..893448 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893429 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 893978..893985 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894000..894019 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894006 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 894483 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 894549 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(894559) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 894885..894889 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 894897..894911 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(894901..894920) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 894901..894992 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 894901 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(894911) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 894969..894972 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 894987..895006 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 894994..895096 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 894994 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 895964..895971 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 895985..896004 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 896000..896272 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 896000 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(896033) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 900923..901008 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 900984..900991 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901005..901024 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901010 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 901326 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 902525..902601 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 902558 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 902603..902771 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 902728..902735 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 902734 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 902749..902768 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902773 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(902807..902824) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(902810) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(902845..902850) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(902880) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(902964) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(903753..903768) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(903775) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(903781..903790) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 903810..903816 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 903831..903842 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 903834 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 904054 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(904130) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(904387..904405) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(904394) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 904409..904416 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(904422..904427) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904429..904448 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 904437 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 905191..905195 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(905194..905213) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905206) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 905209..905228 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(905228..905235) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 905239 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 905370 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 907220 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 907265..908190 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(908665..908684) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908682) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(908698..908707) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908755..908761 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908776..908795 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908804 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(909122) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 910540..910546 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910561..910580 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 910564 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(910581..910600) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 910586..910915 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(910600) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(910614..910621) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(910659..910677) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(910684) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 910872 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 914761..914780 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 914767 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 915375..915445 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 915415..915422 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915436..915455 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915447 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 915558..915562 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915585..915601 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915601 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 915742 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(915809) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(916477..916496) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916491) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916509..916516) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916572..916577 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916591..916610 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916591 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 916716..916898 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(916821) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 916855 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 916900..917511 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(917453..917472) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917474) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917486..917493) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 918681 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 918698..918710 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 918703 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(918757) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 919658..919661 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 919676 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 919677..919696 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 920177 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 920264..920271 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920286..920305 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 920287 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 922267 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 922311 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 922377 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(922410..922585) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(922453) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(922577..922596) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(922585) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(922611..922618) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 922650..922655 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922671..922689 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922671 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 923175..923275 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 923235 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 923301 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 924621 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 924685..924690 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924706..924724 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 924709..924807 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 924709 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 925006..925009 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925024..925043 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925028 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(925269) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 925965 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 926073..926080 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926095..926114 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926095 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 926435..926441 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926456..926474 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926469 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 926619..926625 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926639..926650 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926645 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 929879 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 929980..929986 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930001..930020 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 930011 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(930363..930381) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930377) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(930397..930402) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 933729 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(933853) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(934043..934170) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 934130..934141 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 934147 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(934159..934178) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934170) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(934172..935310) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(934192..934197) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 934337..934344 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 934359..934377 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 934366 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 934367..934477 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 935267 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(936400..936419) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(936421) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(936435..936439) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 936497..936504 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936518..936537 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936524 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(937590..937993) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 937933 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(938464..938482) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938492) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938497..938503) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 938541..938547 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938561..938572 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938565 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 938795..938801 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 938812 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 938815..938826 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 939143 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 939211..939220 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939234..939253 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939244 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 940133 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(940206) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(940873..940884) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(940875) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(940899..940905) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 940914..940922 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 940933..940951 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 940948 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 945150 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 946165..946173 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(946166..946177) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946172) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(946174..946660) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 946184 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946187..946206 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(946191..946197) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(946646..946665) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(946660) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 946700..946706 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 946715 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946720..946731 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(946730..946744) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946744) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(946752..946756) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(947078..947178) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(947118) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 947152 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(947184) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 947224..947231 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947245..947264 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947253 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 949503 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 949826..949833 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 949848..949867 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 949859..949940 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 949859 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 951894..951901 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951916..951935 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951927 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 951942 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 951987..952077 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 953722..953728 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 953743..953762 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 953753 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 954412..954500 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 954457 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 954463..954563 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 954523 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 955981..955986 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 956001..956019 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 956010 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 956064..956070 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956085 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956086..956104 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 956187 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 956232..956305 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 956287..956294 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956307 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956308..956327 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 958085 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 958130..958199 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 958201..958220 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 958201 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 960511 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(960582) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(960839..960850) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(960850) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(960864..960871) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 960938..960944 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 960958..960969 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 960968 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 961328..963194 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(961381) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(961468) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(962875..962893) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(962887) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(962907..962914) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(963018) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 963416..963422 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963436..963447 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 963438..963548 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 963438 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(963450..963469) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963466) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963481..963487) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 963507 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(963540) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(965084..965102) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(965104) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(965116..965122) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 965165..965170 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965186..965204 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965199 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 966610 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(966686) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(968072) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(968074..969605) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(968082..968093) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 968201..968208 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968221..968240 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 968227..968514 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 968227 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 968477..968480 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968495..968514 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 968516 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 969441 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 969571 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(969605) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(969612..969627) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 969617 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(969639..969648) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 970578..970579 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(970591..970610) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 970596..970615 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(970597) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 970606 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(970625..970630) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 971745..971751 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971766..971784 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971771 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 972685 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 972762..972765 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 972777 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 972780..972799 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 972825..972844 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 972830..972926 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 972830 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 974304 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 974385..974389 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974405..974424 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974412 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 975778 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 977290..977293 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977308..977327 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977310 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(977312..977331) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977324) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977347..977351) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 977758 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(977834) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(979646..979748) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(979737..979756) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979748) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979770..979773) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 979786..979792 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 979803 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 979807..979825 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(979836) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 980816 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 980899..980902 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980917..980936 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980922 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 981586 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 981631..983585 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(981659) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(983478..983497) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983488) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983512..983518) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(983514..983614) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 983549..983556 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(983554) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 983570..983589 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 983587 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 984789 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 984834..984972 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 984968..984987 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 984974..985130 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 984974 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 986406 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 986492 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(988021..988040) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(988042) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 988089..988097 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988106 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988111..988126 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 988120..988193 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 988180..988181 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988195 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988197..988216 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 988338..988391 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 988362 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 988442..988461 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 988448 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 989581 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 989638..989657 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 989638 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 990386 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(990462) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 991282..991287 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(991287..991386) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 991303..991321 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991305 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 991310..991505 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(991375..991394) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(991389) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(991409..991412) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 991504..991523 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 991507..991570 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 991507 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 992410 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(992486) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(993824..993894) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(993867..993886) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(993894) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(993982) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(994472..994490) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994492) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994505..994511) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994529..994536 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 994544..994613 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 994545 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 994551..994570 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 994705 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 994776..994894 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 998658 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(998734) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 999324..999424 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(999353..999372) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999368) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 999384 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999387..999390) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(999517..999536) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999526) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999550..999559) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 999582 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(999613) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(999812..999922) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 999852..999952 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 999912 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(999928) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(999932..999943) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(999958..999964) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(1000054) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1000279..1000298) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000296) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1000312..1000319) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(1000406) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1000450) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(1002154..1002168) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002166) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002182..1002190) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1002831..1002936) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1002920..1002938) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002940) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002954..1002959) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003002..1003009 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003024..1003043 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003035 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 1004231..1004322 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 1004664 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(1004827) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005815..1005834) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005827) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005848..1005855) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1005930..1005937 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005950 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1005952..1005971 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1005961..1006114 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1006071 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 1006116..1006199 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1006156 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 1006212..1006217 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1006233..1006251 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1006242 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 1007127 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1007190..1007193 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1007208..1007227 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007216 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 1008732 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(1008786) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(1010915..1010934) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1010939) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1010948..1010955) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010975..1010982 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010997..1011016 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1011007 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 1011836 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(1012077..1012095) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1012088) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1012106..1012114) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1012115..1012118 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1012133..1012152 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1012143 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 1014300 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1014364..1014371 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1014383..1014402 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1014388 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(1015124) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 1016935..1016940 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1016956..1016974 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1016962 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1018553..1018558 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018573..1018592 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018588 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 1019541 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 1019622..1019627 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019643..1019661 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019646 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 1019893 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(1019931) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(1020129) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1020857..1020876) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020881) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1020890..1020897) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1020917..1020926 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020938 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1020939..1020958 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1020975..1020989) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020976) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(1020998..1021002) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1021066..1021317 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 1021274 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(1021286..1021548) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1021319..1021802 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1021329) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1021541..1021560) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021548) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1021550..1021618) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1021574..1021579) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 1021924..1021932 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1021944..1021962 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1021957 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1022168..1022187) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022186) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022203..1022209) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022286..1022289 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022304..1022323 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022309 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(1022540..1022682) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1022583) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 1022687..1023452 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1022759) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 1023290..1023294 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023302..1023315 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023314 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1023319..1023338) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1023342) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(1023353..1023356) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1023409 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(1023476) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1023905..1023910 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1023911..1023930) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1023925) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1023926..1023944 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023926 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1023927..1024190) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 1024150..1025585 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(1024235) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(1024742..1024829) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1024821..1024840) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1024829) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1024854..1024861) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1025984..1026003) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1025995) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1025997..1026078) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1026123) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1026562..1026581) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026576) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1026579 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1026595..1026602) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1026601..1026897) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1026644) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1026895..1026906) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026901) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1026921..1026927) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1026957..1026964 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1026978..1026997 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1026987 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1028312..1028330) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1028327) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1028346..1028351) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1029673 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1029737) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1029802) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1030941..1030960) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030962) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1030974..1030979) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1032392..1032411) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032397) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032424..1032433) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1032833) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1033319..1033338) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1033321..1033325 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1033340) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1033341..1033360 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033342 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033355..1033356) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1033373..1033379 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1033394..1033405 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033399 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1033472..1033483) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033475) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033497..1033503) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1035609..1035615 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1035629..1035648 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035639 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1037777 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1039163 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1039247..1039254 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039268..1039287 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039273 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1039651..1039654 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039669 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039671..1039690 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1039908..1039977 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1042287 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1042360) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1043338..1043357) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043356) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1043371..1043377) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1043383..1043391 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043402..1043420 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043409 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1043943..1044564) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1044228..1044599 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1044542..1044561) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044563) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1044575..1044584) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044577..1044584 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1044599..1044618 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044601 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1046071 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1046167) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1047427..1047527) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1047526..1047545) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047527) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1047529..1047665) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1047560..1047566) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1047710) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1047856..1047875) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047875) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1047888..1047895) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1047919..1047925 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047939..1047958 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047942 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1050428 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1050468..1050471 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050486..1050505 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050493 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1052078 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1052154) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1052552..1052563) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052556) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052578..1052584) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1052617..1052620 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1052628 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1052635..1052654 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1053108..1053127) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053122) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1053143..1053148) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1053948 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1053998) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1055146..1055212) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1055201..1055220) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1055218) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1055236..1055240) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1055525..1055532 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1055547..1055566 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1055549 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1056045..1056052 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1056067..1056086 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056074 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1057094 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1057139..1057249 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1057227..1057234 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057250..1057269 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057251 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1058260 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1058336) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1058918..1058937) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058930) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1058953..1058956) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1061512..1061531) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1061526) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1062087..1062106) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1062101) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1062121..1062128) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1062208) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1063549..1063567) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063552) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063581..1063587) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1065190..1065208) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065200) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1065219..1065224 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1065223..1065228) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1065236 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1065240..1065258 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1066114 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1066193) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1066410..1066429) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1066413..1066414 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1066413 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1066417..1066432 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066432) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1066434..1067289) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1066444..1066451) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1066616..1066623 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1066635..1066654 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1066641 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1067265..1067410 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1067334) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1067397..1067400 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1067412 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1067418..1067422 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1067456 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1067501..1068367 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1068237..1068255) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068254) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1068270..1068276) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1068344..1068351 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068366..1068385 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068369 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1068688 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1068736) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1070406..1070524) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1070507..1070526) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1070524) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1070539..1070546) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1070612) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1070813..1070818 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070834..1070852 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070835 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1070844..1071083 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1071005..1071024) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071023) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1071039..1071046) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1071065..1071072 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1071085 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1071086..1071105 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1072251 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1072309..1072316 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072330..1072349 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1072339..1072438 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1072339 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1073946..1073953 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1073965 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1073967..1073986 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1074504 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1074556..1074699) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1074594) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" /label="glcP CDS" gene complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /label="glcP gene" promotor_-35 1075395..1075400 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075417..1075435 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1075420..1075946 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1075421 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="upshifts" downshifts 1075904 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" /label="ntdC CDS" gene complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /label="ntdC gene" CDS complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" /label="ntdB CDS" gene complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /label="ntdB gene" CDS complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" /label="ntdA CDS" gene complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /label="ntdA gene" promotor_-35 1078032..1078037 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1078053..1078071 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1078059..1078847 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1078059 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="upshifts" promotor_-35 1078823..1078830 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078845..1078864 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1078849..1079291 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1078849 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1079223..1079242) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079235) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1079256..1079263) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" /label="ntdR CDS" gene 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /label="ntdR gene" S_feature 1080282..1080659 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1080336..1080494) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1080379) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1081650..1081721) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1081704..1081723) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1081720) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1081737..1081742) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1082982..1083001 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1082987 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1084388..1084395 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1084410..1084429 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1084417 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1085285) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1085744..1085763) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085764) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085776..1085785) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085833..1085840 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085854..1085873 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085866 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1093083..1093153 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1096973..1096979 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1096994..1097005 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1097001 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1097070..1098043) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1098014 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" /label="gerPF CDS" gene complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /label="gerPF gene" downshifts complement(1098088) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" CDS complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" /label="gerPE CDS" gene complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /label="gerPE gene" CDS complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" /label="gerPD CDS" gene complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /label="gerPD gene" CDS complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" /label="gerPC CDS" gene complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /label="gerPC gene" CDS complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" /label="gerPB CDS" gene complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /label="gerPB gene" CDS complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" /label="gerPA CDS" gene complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /label="gerPA gene" S_feature complement(1100005..1100091) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1100019..1100025 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100039..1100058 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1100041..1100696 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1100041 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1100078..1100097) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1100091) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100093..1100222) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1100110..1100119) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1100224..1100426) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1100267) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" /label="pchI CDS" gene complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /label="pchI gene" misc_feature complement(1100641..1100660) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1100644) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100646..1100742) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1100653 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 1100698..1100862 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" /label="yisJ CDS" gene complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /label="yisJ gene" promotor_-10 complement(1101688..1101707) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1101699) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="upshifts" promotor_-35 complement(1101721..1101730) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1101750..1101758 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1101770..1101788 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1101775 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="upshifts" CDS 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" /label="mblK CDS" gene 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /label="mblK gene" S_feature 1102727..1102807 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1102777..1102780 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1102797..1102816 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1102809 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="upshifts" CDS 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" /label="yisL CDS" gene 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /label="yisL gene" downshifts 1103095 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 1103186 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" /label="downshifts" upshifts 1103319 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1103322..1103341 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" /label="wprA CDS" gene 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /label="wprA gene" downshifts complement(1103534) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" /label="downshifts" downshifts 1106042 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1106683..1106702) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1106702) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1106718..1106720) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1106723..1106729 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106741 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1106744..1106762 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1106747..1106813 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1108659..1108726 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1108683 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1109287) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1109291..1109309) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1109320..1109328) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1109459..1109463 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1109476 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1109478..1109497 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1109711..1109717 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109732..1109750 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1109739 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1110333..1111783 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1111752..1111759 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111773..1111792 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1111785 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1113721 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1113790..1113797 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1113812..1113831 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1113831..1113946 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1113831 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1114997 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1115045) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1115548..1115566) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115564) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115578..1115586) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1116266..1116272 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1116286..1116305 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1116295 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1117623..1117775) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1117658) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1118415..1118549) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1118463..1118468 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118484..1118502 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118485 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1118495..1118619 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1118535..1118554) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118549) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1118569..1118576) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1119419 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1119473) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1121220..1121331) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1122086..1122105) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1122108) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1122118..1122127) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1122157..1122166 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1122180..1122199 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1122191 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1123665 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1124376..1124394) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1124393) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1124409..1124414) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1124467) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1126856..1126867) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1126865) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1126881..1126887) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1126953) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1128265..1128284) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1128279) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1128300..1128301) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1128361) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1130254) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1130431..1130450) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1130445) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1130465..1130472) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1130995..1130998 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1131001..1131020) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1131013..1131032 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1131014 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1131019) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1131035..1131042) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1131959 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1132035) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1132693) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1134092..1134111) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1134106) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1134126..1134129) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1134197..1134204 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1134219..1134238 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1134222 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1135458 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1135502 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1137218 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1137294) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1137675..1137682 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1137697..1137716 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1137702..1138227 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1137704 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1138169..1138188) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138192) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1138206..1138211 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138226..1138244 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138229 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1138761..1138769 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138780..1138798 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138780 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1139109..1139222 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1139571 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1139626) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139811..1140007) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1140007) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1140009..1140020) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1140035..1140041) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1140917..1140936) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1140937..1140944 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1140937) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140950..1140957) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140956..1140975 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140958 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1141776..1141782 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1141796 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1141797..1141816 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1142124 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1142169..1142434 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1144368 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1144542..1144549 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1144548 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1144563..1144582 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1149514,1149515) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1149793..1149812) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1149803) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1153954 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1153994..1154268) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1154019..1154025 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1154027) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1154040..1154051 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154061 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1154266 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1154313) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1154516..1154535) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1154533) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1154546..1154553) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1154588..1154594 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154606..1154625 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154611 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1154668..1154677 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1154677 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1154690..1154709 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1155229..1155831) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1155451..1155456 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1155469 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1155469 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1155472..1155490 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1155811..1155830) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155831) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155845..1155849) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1156116..1156123 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156138..1156157 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156150 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1156817..1156821 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156837..1156856 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156850 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1157338 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1157383..1157723 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1157405) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1157641..1157660) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157662) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157674..1157683) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157689..1157696 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1157711..1157730 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1157725 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1157870..1157879 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1157888 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1157891..1157906 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1158968..1158986) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158976) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1159002..1159007) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1159846 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1159979 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1160020..1160029 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1160042..1160061 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1160044 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1160056..1160064 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1160076..1160094 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160088 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1160857..1160941 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1160873..1160891) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160890) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1160906..1160911) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1160909..1160916 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160931..1160950 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1160943..1161047 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1160943 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1163026..1163032 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1163031..1163107 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1163031 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1164729 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1166706 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1166751..1166858 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1166831..1166836 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166852..1166870 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166860 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1167629 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1167705) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1168783) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1168968..1168987) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1168981) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1169236..1169243 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1169257..1169419 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1169258..1169277 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1169258 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1170951 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1171058..1171164 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1171208..1171227) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171225) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171243..1171249) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1174991 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1175071..1175074 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175087 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1175089..1175108 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1176398..1176407 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1176420..1176435 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1176429..1176508 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1176429 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1177088..1177202 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1177139..1177158) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177143) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1177172..1177179) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1177205..1177218 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1177205 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1177499..1177599) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1177539) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1177661 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1177706..1178495 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1178392..1178410) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1178407) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1178425..1178430) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1178468..1178475 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178489..1178508 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178497..1178638 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1178497 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1179285 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1179330..1179419 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1179398..1179406 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1179417..1179435 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1179421..1179485 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1179421 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1180261..1180267 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1180279 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1180282..1180300 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1180493..1180501 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1180513..1180531 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1180520 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1180601..1180607 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180622..1180633 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180631 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1180729..1180736 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1180751..1180770 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1180763 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1182613 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1182667..1182968 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1182717) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1182891..1182909) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1182907) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1182925..1182930) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1182961..1182968 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1182970..1183095 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1182970 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1182983..1183002 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1183052 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1183216) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1183420..1183425 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1183432 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1183441..1183459 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1183448..1185349 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1184480..1184659) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1184651..1184670) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1184659) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1184682..1184689) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1184758) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1185280..1185482) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1185628..1185646) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1185637) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1185659..1185666) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1186084..1186103) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1186101) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1186117..1186120 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1186118..1186125) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1186133 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1186136..1186155 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1188904 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1188980) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1189814..1189818 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1189835..1189854 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1189849 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1189850..1189926 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1190254..1190273) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1190278) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1191773..1191780 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1191794..1191813 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1191800 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1191936 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1197197 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1197270..1197276 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197289..1197308 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197299 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1198124 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1198183..1198188 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198204..1198222 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198208 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1198220..1198234) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198220) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1198242..1198246) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1198914 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1199002 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1199034) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1199460..1199586) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1199755..1199761 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199776..1199795 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199794 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1200071..1200075 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200084..1200098 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200102 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1200112..1200131) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200129) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200145..1200154) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1200161..1200179) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200178) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200195..1200200) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1200212 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1200251) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1200256 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1200746..1200843) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1201584..1201588 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201596..1201610 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201598 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1201608..1201627) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1201630) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1201632..1202136) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1201685..1201690 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1201706..1201724 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1201708 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1202114..1202123 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1202121..1202140) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1202136) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1202137..1202323 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1202137..1202154 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1202137 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1202154..1202163) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1202180) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1202280 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1202334) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1202335..1202344 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1202342..1202349) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1202358..1202377 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202368 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1202616..1202625 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202638..1202657 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202643 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1202650..1202664) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1202664) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1202674..1202678) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1202764 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1202824..1202955 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1203195 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1203214) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1203240..1204340 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1203302) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1205438..1205612) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1205491..1205499 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205510..1205528 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1205514..1205649 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1205514 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1205600..1205619) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205611) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1205627..1205633 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1205635..1205639) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205648..1205666 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205651 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1205910 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1206000) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1207746..1207765) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1207767) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1207816..1207823 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1207838..1207857 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207842 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1208000 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1210332 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1210366..1210384 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1210376 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1210377..1211906 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1210403) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1212213..1212232) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212217) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212247..1212254) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1212281..1212288 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1212292 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1212302..1212321 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1212374..1212391) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212388) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212412..1212418) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1212422 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1212447..1213182) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1212467..1214115 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1212476) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1213184..1213272) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1213227) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1213395) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1214072 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1214503..1214588) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1214543..1214550 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1214565..1214584 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1214574..1214593) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1214578 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1214592) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1214606..1214612) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1214958 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1215003..1215100 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1215890..1215897 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1215912..1215931 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1215920..1216160 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1215920 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1216133..1216140 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1216154..1216172 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1216162 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1216954 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1216986) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1216997..1217000) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1217819..1217824 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217837..1217856 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217840 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1218164..1218399 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1219156..1219243 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1219200 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1219243..1219303) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1219274) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1219683..1219701) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219696) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1219698..1220154) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1219712..1219720) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1220114..1220132 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1220126 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1220132..1220151) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1220154) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1220165..1220172) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1222124 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1222178..1222179 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1222179..1222277 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1222252..1222258 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1222273..1222292 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1222279..1222347 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1222279 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1222348..1222830 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1222348..1222830 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1222810 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1222876..1223382) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1222876..1223382) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1222900) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1223407..1223426) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1223413) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1223415..1223600) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1223601..1223996) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1223601..1223996) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1224019..1224037) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224032) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1224034..1224734) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1224052..1224057) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1224140..1224147 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1224161..1224180 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1224172 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1224225..1224704 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1224225..1224704 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1224703 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1224744..1224938) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1224744..1224938) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1224779) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1224952..1224967) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224968) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1224979..1224988) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1225104..1225433) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1225104..1225433) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1225470..1225489) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225483) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1225485..1226052) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1225504..1225509) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225537..1225541 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1225557..1225576 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1225561..1226062 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1225561 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1226053..1227042) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1226053..1227042) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1227043..1227062) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1227046) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1227076..1227081) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1227165..1227413) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1227165..1227413) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1227175) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1227409..1227413 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1227422..1227436 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227431 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1227438..1227457) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227447) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1227471..1227480) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1227528..1227535 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1227542..1227561) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1227549..1227568 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227551) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1227562 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1227563..1227666 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1227575..1227582) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1227667..1229070 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1227667..1229070 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1229059 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1229110..1229583) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1229110..1229583) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1229114) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1229605..1229623) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229623) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229638..1229643) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1229708..1229875) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1229708..1229875) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1229711) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1229887..1229905) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229896) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229918..1229925) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1230002..1230901 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1230002..1230901 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1230910..1231308) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1230910..1231308) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1230940) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1231337..1231356) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1231356) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1231371..1231378) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1231409..1231984) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1231409..1231984) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1231424) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1232003..1232021) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232018) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232035..1232041) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1232059..1232065 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232080..1232098 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232081 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1232130..1235087 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1232130..1235087 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1235080..1235640 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1235080..1235640 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1235633 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1235678..1235796 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1235774..1235777 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235793..1235812 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235798 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1235837..1236478 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1235837..1236478 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1235846) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1236451 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1236557..1237183 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1236557..1237183 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1237185 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1237188) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1237214..1237492) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1237214..1237492) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1237232) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1237521..1237532) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1237534..1237540) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1237540) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1237542..1237958) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1237710 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1237711..1237730 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1237728..1237882 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1237883..1239073 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1237883..1239073 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1237956..1237975) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1237958) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1237989..1237998) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1239096..1240274 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1239096..1240274 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1240315..1240503) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1240315..1240503) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1240331) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1240529..1240548) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240532) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240562..1240568) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240590..1240597 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240612..1240631 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240623 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1240638..1240657) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240642) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240672..1240679) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1240677..1241489 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1240677..1241489 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1241468 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1241535..1242287) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1241535..1242287) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1241544) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1242287..1243039) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1242287..1243039) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1243159..1244133) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1243159..1244133) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1243194) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1244154..1244173) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244180) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1244182..1246688) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1244188..1244195) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1244216..1244222 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244237..1244255 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1244240 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1244265..1244762 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1244265..1244762 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1244763..1244876 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1244856..1244860 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244876..1244895 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1244878..1245150 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1244878 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1245151..1245573 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1245151..1245573 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1245613..1246791 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1245613..1246791 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1246622..1246722 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1246680..1246698) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246682 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1246688) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1246710..1246718) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1246790 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1246899..1246906 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246921..1246940 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246946 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1246989..1248410 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1246989..1248410 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1248478..1249857 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1248478..1249857 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1248997..1249016) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1249002) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1249030..1249037) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1249882 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1249892..1249899 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1249894..1249961 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1249962..1250975 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1249962..1250975 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1250981..1252000 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1250981..1252000 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1252025..1253104 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1252025..1253104 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1253101..1253937 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1253101..1253937 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1253985..1255253 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1253985..1255253 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1255197..1255200 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255216..1255220 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255218 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1255286..1255305 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1255286 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1255341..1256342 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1255341..1256342 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1256024..1256124) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1256064) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1256318 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1256419..1257861 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1256419..1257861 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1257858..1259351 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1257858..1259351 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1259390..1260154) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1259390..1260154) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1259409) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1259922,1259924) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1260181,1260188) /created_by="User" /modified_by="User" /label="TF8A" N_region 1260182..1260187 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1260190..1260510 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1260190..1260510 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1260519 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1260528..1260731) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1260547..1260684) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1260547..1260684) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1260571) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1260770..1260940) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1260770..1260940) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1260776) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1260940..1261686) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1260940..1261686) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1261521..1261540) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261538) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261556..1261563) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1261712..1261730) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261725) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261746..1261751) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1261796..1262797) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1261796..1262797) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1261825) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1262810..1263427) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1262810..1263427) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1263463..1263482) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263465) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1263467..1263564) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1263498..1263502) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1263544..1263563) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263564) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263578..1263585) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1263609..1263628) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1263621) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1263703..1265019) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1263703..1265019) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1263718) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1265066..1265085) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1265082) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1265100..1265103) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1265302..1265309 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1265324..1265343 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1265336..1265407 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1265336 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1265408..1266358 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1265408..1266358 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1266346 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1266459..1266605 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1266459..1266605 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1266613..1268763 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1266613..1268763 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1267502..1267602 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1267562 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1267650 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1268775..1269746 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1268775..1269746 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1269103..1269744) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1269789) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1269814..1270180) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1269857) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1270160..1270175) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270180) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270187..1270196) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1270264..1271613) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1270264..1271613) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1270278) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1271653..1271660 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1271665..1271684) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271673 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1271675..1271694 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1271683) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1271685..1271767) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1271695..1271702) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1271724..1271730 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271745..1271764 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271748 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1271750..1271769) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1271767) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1271782..1272600 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1271782..1272600 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1271785..1271788) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1272578 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1272657..1272664 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272679..1272698 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272683 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1272729..1273553 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1272729..1273553 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1273570..1274496 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1273570..1274496 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1274502..1275464 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1274502..1275464 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1275196..1275201 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275217..1275235 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1275218 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1275469..1276476 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1275469..1276476 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1276479..1278128 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1276479..1278128 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1278122 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1278216..1279175 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1278216..1279175 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1279172..1280272 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1279172..1280272 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1280269..1281159 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1280269..1281159 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1281172..1282161 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1281172..1282161 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1281455..1282182) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1282151 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1282196..1283364 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1282204..1283253) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1282204..1283253) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1282227) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1283280..1283299) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283291) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1283314..1283321) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1283343..1284203) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1283343..1284203) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1284228..1284246) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284245) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1284262..1284268) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1284277..1284284 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1284298..1284317 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1284305 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1284363..1284881 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1284363..1284881 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1284872 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1284946..1284952 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1284964..1285070 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1284964 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1284966..1284977 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1285045..1285048 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285064..1285083 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285072 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1285120..1286319 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1285120..1286319 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1286308 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1286353..1286724 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1286396..1286620) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1286396..1286620) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1286700..1286706 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1286720..1286731 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1286726 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1286765..1287496 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1286765..1287496 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1287474 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1287535..1287543 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287554..1287572 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287562 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1287588..1288115 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1287588..1288115 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1288105..1288623 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1288105..1288623 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1288617..1288624 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1288638..1288657 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1288641 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1288656..1288767 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1288656..1288767 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1288730 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1288845..1289183 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1288845..1289183 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1289183..1289500 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1289183..1289500 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1289500..1289503 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289519..1289538 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289531 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1289571..1290473 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1289571..1290473 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1290464 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1290520..1290526 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1290532 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1290540..1290559 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1290561..1290771 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1290561..1290771 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1290729 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1290824..1291921 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1290824..1291921 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1291011..1291013 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291015..1291019 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291015 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1291933..1293180 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1291933..1293180 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1293171 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1293242..1293249 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1293264..1293283 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1293273 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1293306..1293731 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1293306..1293731 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1293720 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1293762..1294205) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1293762..1294205) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1293796) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1294232..1294251) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294238) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294266..1294269) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1294287..1294293 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294307..1294325 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294313 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1294348..1294758 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1294348..1294758 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1294736 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1294785..1294955 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1294785..1294955 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1294956..1295633 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1295005..1295475) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1295005..1295475) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1295029) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1295497..1295516) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1295513) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1295515..1295622) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1295532..1295535) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1295591 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1295648..1297936) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1295648..1297936) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1295667) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1297937..1297999) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1297959..1298059) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1297999) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1298064..1298219) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1298064..1298219) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1298065) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1298252..1298271) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298264) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1298266..1298351) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1298287..1298294) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1298352..1299311) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1298352..1299311) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1299312..1299363) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1299356..1299375) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1299368) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1299389..1299395) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1299480..1299483 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1299496 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1299499..1299518 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1299534..1300367 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1299534..1300367 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1300343 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1300398..1301162) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1300398..1301162) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1300419) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1301137..1302780) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1301137..1302780) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1302767..1303366) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1302767..1303366) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1303368..1303970) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1303368..1303970) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1304048) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1304067..1304179) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1304067..1304179) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1304180..1304183 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1304194..1304213) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1304199..1304218 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1304210 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1304215) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1304228..1304235) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1304281..1304967 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1304281..1304967 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1304971..1306335 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1304971..1306335 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1306332..1307012 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1306332..1307012 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1307041..1307046 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307062..1307080 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307065 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1307104..1307616 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1307104..1307616 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1307602 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1307647..1307653 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307667..1307678 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307668 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1307699..1307836 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1307699..1307836 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1307809 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1307895..1307902 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307916..1307935 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1307918..1308237 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1307918 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1307950..1308103 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1307950..1308103 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1308215..1308224 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308237..1308256 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1308239..1308340 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1308239 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1308341..1309696 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1308341..1309696 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1309687 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1309739..1310071) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1309739..1310071) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1310087..1310106) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1310097) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1310099..1310487) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1310122..1310127) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1310159..1310259 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1310219 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1310266..1310421 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1310266..1310421 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1310430..1310437 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310444..1310461 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310461 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1310472..1310491) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1310487) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1310505..1310511) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1310509..1310691 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1310509..1310691 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1310659 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1310716..1310724 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310735..1310753 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1310741..1310823 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1310741 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1310824..1311288 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1310824..1311288 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1311273 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1311303..1312424) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1311303..1312424) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1311712..1311720 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311734..1311753 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1311737..1312515 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1311737 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1312453..1312464) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1312473) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1312479..1312485) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1312516..1313067 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1312516..1313067 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1313035 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1313095..1313907) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1313095..1313907) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1313867..1313886) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313881) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313900..1313905) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1314008..1314014 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1314025..1314099 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1314025 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1314028..1314039 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1314100..1315794 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1314100..1315794 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1315807..1316820 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1315807..1316820 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1316805 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1316846..1318681) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1316846..1318681) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1316895) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1318685..1319620) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1318685..1319620) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1319591..1319602) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319601) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1319617..1319623) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1319657..1322059) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1319657..1322059) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1319689) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1321907..1322109) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1322098..1322116) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322109) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322130..1322137) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1322176..1322183 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322197..1322216 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322209 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1322240..1322905 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1322240..1322905 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1322774..1322793) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322791) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322807..1322816) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1322900..1322907 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322922..1322941 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322935 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1322961..1323094 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1322961..1323094 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1322982..1323956 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1322982..1323956 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1323045 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1323944 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1324066..1324074 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1324088..1324096 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1324098 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1324101..1324187 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1324160..1324167 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1324181..1324200 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1324189 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1324220..1324975 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1324220..1324975 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1324972..1326117 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1324972..1326117 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1326118..1327277 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1326128..1326322) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1326128..1326322) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1326135) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1326365..1326376) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1326375) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1326391..1326397) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1326453..1327154) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1326453..1327154) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1326487) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1327155..1327235) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1327227..1327246) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1327235) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1327251..1327258 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1327260..1327267) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1327272..1327291 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1327279 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1327325..1328221 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1327325..1328221 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1328215 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1328326..1328330 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328346..1328365 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328350 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1328395..1329744 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1328395..1329744 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1329732 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1329793..1329799 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329813..1329824 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1329821..1329888 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1329821 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1329889..1330044 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1329889..1330044 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1330047..1330223 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1330047..1330223 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1330113..1330213 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1330173 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1330219 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1330266..1331288) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1330266..1331288) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1330289) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1331333..1331352) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1331349) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1331364..1331370) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1331477..1331485 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1331493 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1331496..1331514 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1331541..1333757 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1331541..1333757 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1333532..1334472) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1333610..1333617 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1333632..1333651 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1333634 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1333754..1334251 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1333754..1334251 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1334252..1334491 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1334341..1334466 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1334341..1334466 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1334459 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1334500..1335561) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1334500..1335561) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1334517) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1335569..1336762) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1335569..1336762) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1335629 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1336849) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1336855..1337011) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1336855..1337011) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1337046..1337065) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337047) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337081..1337088) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1337091..1337094 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1337095..1337874) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1337095..1337874) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1337110..1337129 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1337119 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1337567..1337574 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1337587..1337606 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1337602 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1337609..1337926 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1337896..1337903 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1337904..1337923) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1337918..1337937 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337918) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1337928 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337939..1337946) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1337969..1339165 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1337969..1339165 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1339147..1339154 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1339169..1339188 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1339188 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1339204..1339304 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1339204..1339304 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1339303 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1339389..1340606 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1339389..1340606 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1340603..1341310 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1340603..1341310 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1341268..1341897 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1341268..1341897 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1341912..1342448 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1341912..1342448 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1342295..1342488) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1342448 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1342489..1342809) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1342489..1342809) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1342547) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1342810..1342899) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1342835..1342841 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342856..1342874 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342866 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1342867..1342951 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1342881..1342900) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1342898) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1342915..1342918) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1342925..1342932 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342947..1342966 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1342953..1343011 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1342953 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1343009) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1343012..1343269 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1343012..1343269 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1343263 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1343355..1343786 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1343355..1343786 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1343814..1345334) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1343814..1345334) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1343826) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1344535..1344541 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1344555..1344566 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1344561 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1345342..1345361) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1345363) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1345461..1345468 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345483..1345502 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345485 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1345527..1345964 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1345527..1345964 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1345947 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1346004..1346789) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1346004..1346789) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1346023) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1346485) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1346761..1347573) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1346761..1347573) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1347604..1347622) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1347620) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1347636..1347643) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1347711..1347933) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1347743) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1347956..1350055) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1347956..1350055) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1347978) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1350056..1350306) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1350266..1350366) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1350306) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1350342..1350347 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1350357 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1350363..1350381 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1350420..1351463 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1350420..1351463 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1351464..1351555 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1351532..1351536 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351553..1351572 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351557 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1351602..1351646 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1351602..1351646 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1351623 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1351668..1351775 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1351776..1352435 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1351776..1352435 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1352428..1352877 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1352428..1352877 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1352870..1353601 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1352870..1353601 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1353619..1354116 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1353619..1354116 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1354117..1354393 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1354351 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1354361) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1354430..1354674) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1354471) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1354675..1355031) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1354675..1355031) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1355062..1355081) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1355079) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1355116..1355134 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1355121 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1355200..1355946 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1355200..1355946 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1356001 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1356349..1356357 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356371..1356390 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356375 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1356427..1357626 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1356427..1357626 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1356509..1356515 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356530..1356548 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356536 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1357595..1357597 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1357617..1357635 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357629 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1357642..1357869 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1357642..1357869 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1357719..1357738) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1357727) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1357870..1357965 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1357966..1358664 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1357966..1358664 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1358617..1359443) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1358645..1358896 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1358645..1358896 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1359146..1359161 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1359169..1359380 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1359169 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1359345 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1359432..1359451) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359454) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1359467..1359474) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1359519..1359526 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359541..1359560 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359543 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1359579..1359869 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1359579..1359869 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1359906..1359989) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1359949) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1359990..1360175) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1359990..1360175) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1360208..1360227) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360219) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1360221..1360565) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1360241..1360248) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1360274..1360279 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1360295..1360314 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1360302 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1360341..1360535 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1360341..1360535 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1360511 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1360556..1360574) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360572) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1360591..1360596) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1360834..1361460 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1360834..1361460 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1361391 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1361517..1361522 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1361529 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1361538..1361556 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1361578..1362915 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1361578..1362915 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1362966..1363463 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1362966..1363463 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1363312..1363318 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1363327 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1363333..1363351 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1363437 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1363558..1363564 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363575..1363594 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363587 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1363591..1363698 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1363699..1365612 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1363699..1365612 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1363848..1363867) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363865) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1363880..1363889) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1364016..1364035) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364041) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1364049..1364055) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1365593 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1365669) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1365880..1365899) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365889) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1365913..1365920) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1365964..1365983 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1365974 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1366019..1367110 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1366019..1367110 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1366759 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1367089 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1367123..1367341) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1367134..1367391 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1367328..1367347) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1367341) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1367363..1367370) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1367392..1368357 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1367392..1368357 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1368375..1368382 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1368397..1368416 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1368409 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1368420..1369286 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1368420..1369286 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1369141..1369145 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369162..1369181 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369170 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1369288 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1369333..1369484 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1369333..1369484 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1369333..1369484 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1369462..1369468 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369482..1369493 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369486 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1369515..1371614 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1369515..1371614 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1371632..1371636 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1371652..1371671 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1371663 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1371712..1371978 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1371712..1371978 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1371978..1373690 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1371978..1373690 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1373677 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1373730..1373736 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1373751..1373762 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1373754 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1373781..1374020 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1373781..1374020 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1373801..1375140) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1374098..1375126 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1374098..1375126 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1375096 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1375141..1375821) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1375141..1375821) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1375831..1375850) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375854) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1375865..1375872) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1375906..1375913 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1375927..1375945 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1375933 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1375956..1377923 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1375956..1377923 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1376396..1376411) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1376408) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1377894 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1377967..1377969 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377985..1378004 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1377995 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1378037) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1378061..1378927 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1378061..1378927 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1378907 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1378966..1379739) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1378966..1379739) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1378983) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1379771..1379790) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1379781) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1380014..1380033 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1380027 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1380029..1380132 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1380076..1382190 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1380076..1382190 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1381369..1381387) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381381) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1381403..1381408) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1382171 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1382263..1382271 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1382283..1382301 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1382295 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1382354..1384174 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1382354..1384174 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1384185..1385366) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1384185..1385366) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1384219) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1385394..1385413) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385410) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1385442..1385460) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385454) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1385456..1385524) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1385475..1385480) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1385518..1385537) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385524) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1385568..1385729) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1385568..1385729) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1385752..1385771) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385765) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385785..1385792) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1385866..1385873 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1385885 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1385886..1385904 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385933..1386844 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1385933..1386844 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1385938) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1386387..1386395 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386409..1386426 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386412 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1386829 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1386888..1387352) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1386888..1387352) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1386906) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1387382..1387401) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387392) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1387416..1387423) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1387478..1388770) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1387478..1388770) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1387500) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1388794..1388813) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1388798) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1388829..1388833) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1388846..1389340) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1388846..1389340) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1389356..1389375) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389372) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1389389..1389398) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1389397..1390257) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1389397..1390257) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1390278..1390297) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1390291) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1390328..1390335 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1390351..1390370 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1390364 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1390400..1391164 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1390400..1391164 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1391165..1391313 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1391294..1391312 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1391315..1391464 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1391315 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1391362) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1391465..1393195 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1391465..1393195 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1393261..1393779 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1393261..1393779 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1393777 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1393822..1393827 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393840..1393859 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393843 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1393875..1394423 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1393875..1394423 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1394424..1394575 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1394576..1395799 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1394576..1395799 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1395762..1395780) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395772) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1395778 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1395795..1395800) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1395848..1395855 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1395867..1395968 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1395867 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1395870..1395889 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1395885..1395968 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1395885..1395968 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1395925 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1395979..1395984 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1395999..1396283 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1395999 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1396001..1396019 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1396260..1396266 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1396280..1396291 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1396285..1396372 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1396285 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1396361..1396380 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1396374 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1396445..1396684 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1396445..1396684 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1396685..1396793 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1396794..1397312 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1396794..1397312 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1397349..1397356 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1397370..1397389 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1397384 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1397446..1397643 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1397446..1397643 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1397639 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1397684..1397780 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1397781..1398224 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1397781..1398224 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1398225..1398332 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1398300..1398305 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398320..1398339 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398334 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1398373..1399254 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1398373..1399254 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1399233 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1399289..1399296 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1399311..1399330 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1399316 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1399366..1399842 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1399366..1399842 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1399832..1400725 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1399832..1400725 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1400741..1401196 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1400741..1401196 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1401012..1401031) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401025) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401045..1401053) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1401190 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1401235..1401242 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1401256..1401275 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1401257 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1401301..1402011 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1401301..1402011 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1401310) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1401420..1401424) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401420) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1402081..1403205 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1402081..1403205 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1403217..1403223 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403237..1403248 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1403239 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1403243..1403257) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1403267..1403271) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1403267..1403512 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1403267..1403512 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1403268) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1403500 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1403545..1404495 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1403549..1404352) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1403549..1404352) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1403561) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1404403..1404422) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1404412) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1404436..1404443) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1404468..1404475 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1404490..1404509 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1404497..1404588 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1404497 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1404589..1405131 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1404589..1405131 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1405203..1405649 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1405203..1405649 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1405657 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1406042..1406049 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1406062 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1406064..1406083 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1406115..1406690 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1406115..1406690 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1406668 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1406731..1407696) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1406731..1407696) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1406744) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1407040..1407041 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1407059..1407078 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1407065..1407789 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1407065 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1407717..1407735) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407738) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1407750..1407755) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1407776..1407782 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1407792 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1407796..1407815 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1407833..1408432 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1407833..1408432 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1408483..1409502 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1408483..1409502 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1409520..1410812 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1409520..1410812 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1410773..1411294 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1410773..1411294 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1411294..1411767 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1411294..1411767 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1411760..1411993 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1411760..1411993 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1411972 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1412038..1412043 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1412060..1412078 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1412068 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1412080..1412166 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1412156..1412159 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1412168 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1412174..1412193 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1412217..1413974 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1412217..1413974 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1413986..1415800 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1413986..1415800 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1414423..1414442) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414433) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1414457..1414464) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1415851..1415860 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1415872..1415887 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1415876 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1415910..1416605 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1415910..1416605 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1416610..1417743 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1416610..1417743 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1417744..1418436 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1417744..1418436 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1418433..1419626 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1418433..1419626 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1419604 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1419675..1419681 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1419695..1419706 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419703 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1419748..1419755 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1419770..1419789 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1419775..1419866 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1419775 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1419830..1419837 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1419851..1419870 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419868 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1419906..1420661 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1419906..1420661 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1420054) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1420056..1420058) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1420658..1421569 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1420658..1421569 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1421584..1423491 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1421584..1423491 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1423476 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1423560..1423567 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1423578..1423597 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1423581 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1423636..1424217 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1423636..1424217 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1424202 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1424246 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1424251..1424520) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1424251..1424520) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1424256) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1424521..1424586) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1424567..1424586) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1424586) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1424639..1424646 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1424657..1424676 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1424661 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1424701..1426323 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1424701..1426323 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1426311 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1426380..1427291 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1426380..1427291 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1427296 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1427325..1428557) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1427325..1428557) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1427336) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1428575..1428594) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428599) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1428609..1428614) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1428667..1428801) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1428667..1428801) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1428678) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1428823..1428841) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428834) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1428836..1428901) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1428857..1428862) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1428902..1429909) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1428902..1429909) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1429955) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1429956..1429964) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1429978..1429986) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1430096..1430105 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1430117 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1430118..1430133 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1430120..1430192 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1430193..1430471 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1430193..1430471 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1430469 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1430503..1432132) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1430514..1430618 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1430526) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1430600..1430607 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430619..1430638 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1430620 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1430661..1431947 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1430661..1431947 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1431963..1432796 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1431963..1432796 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1432129..1432147) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1432144) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1432163..1432168) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1432859..1433524 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1432859..1433524 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1433508 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1433615..1433621 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1433636..1433655) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1433636..1433655 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433648 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1433650) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1433679..1435412 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1433679..1435412 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1434807..1435411) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1435401 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1435446..1437113) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1435446..1437113) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1435456) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1437119..1437328) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1437119..1437328) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1437365..1437384) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1437387) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1437389..1437566) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1437399..1437402) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1437567) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1437569..1437580) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1437594..1437600) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1437639..1437646 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1437660..1437679 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1437676 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1437714..1438487 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1437714..1438487 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1438458 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1438523..1439077) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1438523..1439077) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1438534) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1439099..1439118) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439109) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439133..1439140) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1439162 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1439186) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1439187..1439345) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1439187..1439345) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1439252..1439395) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1439252..1439395) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1439341..1439345 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1439346..1439414) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1439355..1439369 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439382 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1439398..1439417) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439427) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439430..1439439) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1439501..1439508 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439522..1439541 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439526 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1439559..1440230 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1439559..1440230 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1439898..1439907 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439920..1439938 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439932 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1440177 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1440405..1440410 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440427..1440446 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1440428..1440653 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1440428 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1440432..1440451) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1440448) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1440552..1440560) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440558) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1440574..1440582) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1440654..1441769 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1440654..1441769 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1441773..1442750 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1441773..1442750 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1442751..1442864 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1442785..1442804) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1442802) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1442819..1442822) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1442865..1444193 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1442865..1444193 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1443009..1443016 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443031..1443050 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1443034 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1444198..1445610 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1444198..1445610 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1445607 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1445655..1446029) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1445655..1446029) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1445703) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1446060..1446079) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1446070) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1446233..1446238 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1446254..1446272 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1446264 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1446268..1446377 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1446300) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1446361..1446368 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1446379 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1446383..1446402 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1446398..1446608 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1446398..1446608 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1446448..1446567 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1446448..1446567 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1446454) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1446554 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1446599..1448202 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1446607..1448079) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1446607..1448079) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1446625) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1448080..1448175) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1448158..1448177) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1448175) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1448182..1448185 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1448192..1448199) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1448200..1448219 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448204 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1448264..1448530 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1448264..1448530 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1448512 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1448563..1449201) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1448563..1449201) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1448588) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1449222..1449241) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1449246) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1449256..1449260) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1449271..1449277 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449292..1449310 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449293 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1449331..1449340 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449353..1449372 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1449357..1449440 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1449357 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1449441..1449629 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1449441..1449629 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1449446) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1449622 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1449644) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1449652..1449655) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1449699..1449702 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449719..1449738 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449722 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1449769..1450566 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1449769..1450566 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1450592..1451020 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1450592..1451020 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1450977 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1451021..1451974 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1451096) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1451098..1452012) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1451098..1452012) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1452078..1452097) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1452086) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1452112..1452119) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1452364..1453929) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1452364..1453929) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1453964..1453983) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1453975) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1453997..1454004) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1454214..1456154 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1454214..1456154 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1456144..1456413 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1456144..1456413 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1456379..1456383 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456397..1456416 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456410 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1456413..1456934 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1456413..1456934 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1456931..1457224 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1456931..1457224 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1457264..1457875) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1457264..1457875) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1457278) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1457907..1457926) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1457916) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1457941..1457944) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1458131) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1458148..1458336) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1458148..1458336) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1458202) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1458358..1458377) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1458375) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1458390..1458397) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1458403..1458422 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1458410 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1458449..1460287 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1458449..1460287 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1460344..1460661 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1460344..1460661 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1460635 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1460710) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1460717..1460926) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1460717..1460926) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1460940..1460959) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1460955) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1461009..1461638) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1461009..1461638) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1461040) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1461540..1461558) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461546) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1461570..1461578) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1461673..1461684) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461678) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1461690..1461695 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1461699..1461705) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1461711..1461729 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1461711 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1461712..1461792 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1461793..1463121 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1461793..1463121 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1462977..1463124) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1463020) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1463122..1463712 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1463125..1463610) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1463125..1463610) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1463622..1463641) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463650) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1463656..1463663) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1463713..1464642 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1463713..1464642 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1464227..1464246 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1464236 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1464666..1464669 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1464684..1464703 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1464692 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1464740..1465021 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1464740..1465021 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1465010 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1465084..1465087 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1465100..1465226 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1465100 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1465105..1465111 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1465227..1466438 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1465227..1466438 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1466448..1466452 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1466467..1466486 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1466486 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1466513..1469959 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1466513..1469959 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1469525..1469543) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1469545) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1469559..1469564) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1469939 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1469984 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1470016) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1470028 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1470362..1471282) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1470362..1471282) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1470368) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1471322..1471341) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1471337) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1471355..1471362) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1471417..1471424 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471438..1471457 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1471439..1471544 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1471439 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1471546..1471636 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1471546 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1471552..1471555 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471570..1471586 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1471637..1472554 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1471637..1472554 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1472583 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1472602 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1472603..1472608 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1472662..1472667 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1472682..1472700 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1472690..1472793 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1472690 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1472794..1473864 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1472794..1473864 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1473897..1475765 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1473897..1475765 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1475765..1476388 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1475765..1476388 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1476391..1476723 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1476391..1476723 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1476750..1477643 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1476750..1477643 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1477618 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1477675..1478037) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1477675..1478037) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1477694) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1478030..1478034 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478043..1478056 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1478061..1478080) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1478065..1478176 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1478065 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1478073) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1478095..1478102) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1478177..1478623 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1478177..1478623 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1478209..1478216 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478228..1478247 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478233 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1478632..1478639 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478653..1478672 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478664 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1478707..1479747 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1478707..1479747 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1479670..1479688) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1479675) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1479704..1479709) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1479727 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1479911..1479920 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1479934..1479953 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1479948 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1479979..1480377 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1479979..1480377 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1479983) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1480393..1480632 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1480393..1480632 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1480611 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1480699..1480706 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480717..1480736 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480722 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1480748..1481197 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1480748..1481197 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1481183 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1481252..1481524 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1481252..1481524 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1481329..1481552) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1481527..1481647 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1481527..1481647 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1481554..1481677) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1481597) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1481648..1481753 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1481678..1481690) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1481685) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1481705..1481711) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1481734..1481738 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1481754..1481773 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1481755..1481846 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1481755 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1481847..1482401 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1481847..1482401 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1482406..1482891 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1482406..1482891 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1482858 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1482902..1484128) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1482902..1484128) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1482903..1484177 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1484129..1484230) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1484152..1484159 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484171..1484190 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1484179..1484308 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1484179 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1484225..1484243) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1484240) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1484260..1484265) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1484309..1485091 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1484309..1485091 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1484871..1484877 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484891..1484902 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1484902 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1485093..1486118 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1485093..1486118 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1486002 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1486135..1487382) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1486135..1487382) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1486162) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1487299..1487305 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1487319..1487330 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1487323 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1487379..1487564) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1487379..1487564) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1487397..1487401 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1487417..1487436 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1487426..1487561 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1487426 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1487455..1487474) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1487465) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1487488..1487495) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1487532..1487539 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487553..1487572 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487563 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1487592..1488110 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1487592..1488110 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1488132..1488311 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1488132..1488311 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1488291 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1488334) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1488338..1488341) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1488392..1488397 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1488413..1488431 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1488414 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1488457..1489038 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1488457..1489038 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1489039 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1489095..1489577) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1489095..1489577) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1489114) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1489567 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1489600..1489619) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1489619) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1489633..1489640) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1489677..1489683 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1489695..1489714 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1489697 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1489737..1490633 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1489737..1490633 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1490704..1492323 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1490704..1492323 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1492295 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1492357..1492360 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1492375..1492448 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1492375..1492394 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1492375 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1492432) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1492449..1492880 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1492449..1492880 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1492950..1493885 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1492950..1493885 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1493552..1495004) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1493925..1494278 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1493925..1494278 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1494275..1496425 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1494275..1496425 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1494985..1495003) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1495004) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1495018..1495024) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1496408 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1496480..1496485 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1496501..1496519 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1496501 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1496542..1498482 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1496542..1498482 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1498278..1498284 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1498299..1498307 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1498305 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1498455 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1498500..1498567 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1498537..1498541 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1498557..1498576 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1498569..1498657 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1498569 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1498658..1500142 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1498658..1500142 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1500143..1500253 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1500254..1501228 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1500254..1501228 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1501229..1502584 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1501229..1502584 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1502408..1502413 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1502429..1502447 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1502439 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1502645..1503745 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1502645..1503745 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1503746..1503867 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1503868..1504959 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1503868..1504959 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1504348..1504357 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1504370..1504385 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1504375 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1504381..1504481 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1504441 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1504991..1505902 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1504991..1505902 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1505920 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1506032..1506823 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1506032..1506823 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1506820..1507515 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1506820..1507515 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1507538..1508245 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1507538..1508245 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1508263..1508628 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1508263..1508628 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1508480..1508483 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1508499..1508518 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1508515 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1508629..1508801 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1508802..1510124 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1508802..1510124 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1509009) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1509013..1509017) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1509032..1509036) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1510160..1511308 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1510160..1511308 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1511282 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 1511507..1511610 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1511507 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1511509..1511528 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1511611..1515912 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" /label="bpr CDS" gene 1511611..1515912 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /label="bpr gene" downshifts 1515909 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(1515920..1517062) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1515962) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1516040..1516106 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1516042 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="upshifts" misc_feature 1516043..1516062 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1516060..1516072) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1516072) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1516107..1517036 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" /label="spoIIGA CDS" gene 1516107..1517036 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /label="spoIIGA gene" promotor_-10 complement(1517051..1517070) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517064) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1517085..1517088) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1517099..1517818 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" /label="sigE CDS" gene 1517099..1517818 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /label="sigE gene" S_feature 1517819..1517908 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1517892..1517898 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1517910 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1517912..1517923 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1517958..1518740 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" /label="sigG CDS" gene 1517958..1518740 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /label="sigG gene" S_feature 1518741..1518829 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1518794..1518801 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1518814..1518833 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1518831 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1518888..1519682 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1518888..1519682 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1519600..1519603 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1519618..1519637 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1519626 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1519695..1519796 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1519695..1519796 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1519783 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1519884..1521164 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1519884..1521164 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1521105..1521121) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1521110) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1521185..1521190 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1521206..1521224 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1521210 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1521247..1521492 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1521247..1521492 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1521408..1521416 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1521427..1521445 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1521435 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1521493..1521603 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1521595..1521614 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1521605 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1521655..1522491 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1521655..1522491 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1522498..1523190 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1522498..1523190 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1523187..1523642 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1523187..1523642 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1523649..1523921 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1523649..1523921 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1523910 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1523982..1524755 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1523982..1524755 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1524471..1524478 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1524492..1524510 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1524515 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1524756..1524848 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1524849..1525343 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1524849..1525343 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1525356..1525363 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1525377..1525396 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1525384 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1525406..1525632 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1525406..1525632 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1525599 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1525685..1528450 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1525685..1528450 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1528441 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1528496) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1528531..1528537 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1528552..1528563 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1528552 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1528595..1528969 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1528595..1528969 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1529001..1529005 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1529020 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1529021..1529040 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1529072..1529536 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1529072..1529536 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1529538..1530449 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1529538..1530449 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1530444..1530451 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1530466..1530485 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1530480 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1530489..1530605 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1530489..1530605 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1530632..1531177 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1530632..1531177 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1530826) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1531168 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1531181..1531298 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1531181..1531298 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1531351..1532658 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1531351..1532658 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1532659..1532773 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1532659..1532773 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1532804..1533718 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1532804..1533718 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1533702..1534988 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1533702..1534988 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1534985..1536079 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1534985..1536079 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1536064..1539279 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1536064..1539279 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1539276..1540046 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1539276..1540046 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1540046..1540981 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1540046..1540981 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1540950..1541669 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1540950..1541669 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1541648..1542298 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1541648..1542298 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1542300 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1542345..1542417 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1542397..1542404 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1542418..1542437 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1542419 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1542443..1542548 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1542443..1542548 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1542549..1542709 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1542710..1543411 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1542710..1543411 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1543423..1544487 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1543423..1544487 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1544536..1545684 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1544536..1545684 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1544625) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1544637..1544641) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1544659..1544660) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1545697..1546290 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1545697..1546290 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1546291..1546388 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1546389..1547162 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1546389..1547162 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1547067..1547074 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1547089..1547108 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1547090 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1547165..1547950 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1547165..1547950 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1547931..1548419 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1547931..1548419 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1548399 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1548446) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1548459..1550177) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1548459..1550177) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1550199..1550218) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1550213..1550218 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1550213) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1550231..1550236) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1550234..1550252 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1550238 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1550293..1552965 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1550293..1552965 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1551698..1551717) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1551709) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1551732..1551739) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1552971..1552990 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1552974..1553047 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1552974 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1553048..1553923 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1553048..1553923 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1554000..1554269 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1554000..1554269 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1554080..1554084) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1554085) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1554277..1554891 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1554277..1554891 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1554895..1555098 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1554895..1555098 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1555087 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1555179..1556399 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1555179..1556399 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1556238..1556813) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1556396..1558813 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1556396..1558813 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1556809..1556827) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1556813) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1556841..1556847) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1558664..1558668 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1558684..1558703 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1558695 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1558840..1559322 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1558840..1559322 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1559327..1560280 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1559327..1560280 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1560267..1561610 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1560267..1561610 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1561614..1562705 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1561614..1562705 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1562712..1563476 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1562712..1563476 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1562765 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1563470..1565416 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1563470..1565416 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1565325..1565331 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1565345..1565363 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1565361 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1565431..1566327 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1565431..1566327 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1566332..1566985 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1566332..1566985 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1566983..1566992 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1567006..1567025 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1567011 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1567058..1567702 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1567058..1567702 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1567463..1567469 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1567480 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1567484..1567502 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1567593..1567598 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1567614..1567632 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1567627 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1567703..1567773 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1567774..1567854 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1567774..1567854 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1567869 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1567914..1568286 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1567927..1568115) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1567927..1568115) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1567943) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1567989) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1568116..1568208) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1568190..1568209) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1568208) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1568225..1568228) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1568259..1568266 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1568281..1568299 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1568288 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1568327..1568330 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1568345..1568364 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1568353 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1568392..1568754 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1568392..1568754 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1568605) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1568770..1570431 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1568770..1570431 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1570432..1570521 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1570494..1570501 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1570515..1570534 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1570523 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1570570..1571232 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1570570..1571232 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1571258..1572160 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1571258..1572160 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1572138..1574186 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1572138..1574186 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1574222..1574229 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1574244..1574263 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1574250 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1574295..1574861 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1574295..1574861 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1574875..1575876 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1574875..1575876 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1575895..1576848 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1575895..1576848 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1576841..1577581 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1576841..1577581 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1577612..1577616 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577632..1577651 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577637 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1577665..1577898 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1577665..1577898 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1577879 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1577907..1578007 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1577967..1578037 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1577967 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1578038..1578787 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1578038..1578787 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1578759 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1578829..1578835 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1578847..1578866 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1578869 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1578888..1582448 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1578888..1582448 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1582382..1583452) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1582468..1583457 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1582468..1583457 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1583444 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1583494..1583979) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1583494..1583979) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1583497) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1584001..1584019) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1584017) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584033..1584040) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1584082..1584088 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1584103..1584122 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1584105 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1584156..1584488 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1584156..1584488 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1584159) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1584502..1585842 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1584502..1585842 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1585843..1585947 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1585948..1586220 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1585948..1586220 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1586220..1586465 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1586220..1586465 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1586437 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1586482..1586586 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1586587..1586973 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1586587..1586973 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1586978..1587502 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1586978..1587502 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1587499..1588230 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1587499..1588230 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1588236..1588243 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1588257..1588276 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1588261 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1588309..1588350 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1588309..1588350 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1588370..1588717 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1588370..1588717 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1588719 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1588772..1588778 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1588791..1588859 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1588791 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1588792..1588811 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1588860..1589708 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1588860..1589708 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1589729..1589736 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1589749..1589767 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1589759 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1589779..1590546 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1589779..1590546 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1590578..1592308 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1590578..1592308 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1591815) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1591816..1591835) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1591850..1591857) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1592305..1592586 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1592305..1592586 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1592418 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1592587..1592706 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1592678..1592685 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1592699..1592718 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1592708 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1592759..1593916 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1592759..1593916 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1592831..1592931) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1592871) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1593945..1594847 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1593945..1594847 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1594837 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1594908..1595801 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1594908..1595801 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1595807..1595814 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1595829..1595848 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1595836..1595988 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1595836 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1595989..1598064 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1595989..1598064 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1598034 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1598096..1598101 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1598108 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1598117..1598135 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1598140..1599447 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1598140..1599447 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1599453..1599457 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1599474..1599493 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1599484 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1599515..1600429 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1599515..1600429 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1599554..1599558 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1599571 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1599574..1599593 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1600442..1600987 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1600442..1600987 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1601004..1602407 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1601004..1602407 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1602447..1603226 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1602447..1603226 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1603201 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1603245 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1603346..1603353 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1603366..1603384 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1603377..1603530 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1603377 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1603505..1603512 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1603527..1603546 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1603532 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1603606..1603995 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1603606..1603995 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1603995..1604447 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1603995..1604447 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" CDS 1604458..1604778 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" /label="fliE CDS" gene 1604458..1604778 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /label="fliE gene" downshifts complement(1604773) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" /label="downshifts" CDS 1604824..1606434 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" /label="fliF CDS" gene 1604824..1606434 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /label="fliF gene" CDS 1606447..1607463 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" /label="fliG CDS" gene 1606447..1607463 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /label="fliG gene" S_feature 1607464..1607581 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1607527..1607627) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1607567) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1607582..1608208 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" /label="fliH CDS" gene 1607582..1608208 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /label="fliH gene" CDS 1608205..1609521 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" /label="fliI CDS" gene 1608205..1609521 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /label="fliI gene" CDS 1609524..1609967 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" /label="fliJ CDS" gene 1609524..1609967 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /label="fliJ gene" CDS 1609979..1610593 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" /label="ylxF CDS" gene 1609979..1610593 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /label="ylxF gene" CDS 1610606..1612069 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" /label="fliK CDS" gene 1610606..1612069 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /label="fliK gene" CDS 1612066..1612488 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" /label="flgD CDS" gene 1612066..1612488 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /label="flgD gene" CDS 1612510..1613304 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" /label="flgE CDS" gene 1612510..1613304 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /label="flgE gene" CDS 1613344..1613559 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" /label="swrD CDS" gene 1613344..1613559 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /label="swrD gene" CDS 1613556..1613978 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" /label="fliL CDS" gene 1613556..1613978 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /label="fliL gene" CDS 1614012..1615010 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" /label="fliM CDS" gene 1614012..1615010 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /label="fliM gene" CDS 1615000..1616136 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" /label="fliY CDS" gene 1615000..1616136 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /label="fliY gene" CDS 1616162..1616524 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" /label="cheY CDS" gene 1616162..1616524 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /label="cheY gene" CDS 1616539..1617198 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" /label="fliZ CDS" gene 1616539..1617198 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /label="fliZ gene" CDS 1617191..1617856 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" /label="fliP CDS" gene 1617191..1617856 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /label="fliP gene" CDS 1617871..1618140 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" /label="fliQ CDS" gene 1617871..1618140 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /label="fliQ gene" CDS 1618148..1618927 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" /label="fliR CDS" gene 1618148..1618927 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /label="fliR gene" CDS 1618927..1620009 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" /label="flhB CDS" gene 1618927..1620009 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /label="flhB gene" CDS 1620042..1622075 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" /label="flhA CDS" gene 1620042..1622075 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /label="flhA gene" CDS 1622075..1623175 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" /label="flhF CDS" gene 1622075..1623175 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /label="flhF gene" promotor_-10 complement(1623052..1623071) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623059) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623085..1623094) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1623166..1624062 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" /label="flhG CDS" gene 1623166..1624062 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /label="flhG gene" CDS 1624064..1625137 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" /label="cheB CDS" gene 1624064..1625137 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /label="cheB gene" CDS 1625143..1627161 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" /label="cheA CDS" gene 1625143..1627161 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /label="cheA gene" CDS 1627183..1627653 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" /label="cheW CDS" gene 1627183..1627653 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /label="cheW gene" CDS 1627672..1628301 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" /label="cheC CDS" gene 1627672..1628301 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /label="cheC gene" CDS 1628298..1628798 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" /label="cheD CDS" gene 1628298..1628798 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /label="cheD gene" CDS 1628821..1629585 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1628821..1629585 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1629595..1629601 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1629614..1630117 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1629614..1630117 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1629616..1629627 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1629630 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1630113..1630119 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1630134..1630153 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1630136..1630260 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1630136 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1630261..1631001 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1630261..1631001 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1630983 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1631028..1631102 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1631103..1631984 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1631103..1631984 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1631985..1632129 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1632130..1632852 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1632130..1632852 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1632854..1633411 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1632854..1633411 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1633358) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1633400..1633403 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1633418..1633437 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1633436..1633541 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1633436 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1633542..1634324 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1633542..1634324 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1634328..1635137 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1634328..1635137 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1635118..1635125 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1635140..1635159 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1635141 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1635199..1636350 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1635199..1636350 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1636357..1637625 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1636357..1637625 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1637658..1639352 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1637658..1639352 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1639353..1639460 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1639461..1643774 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1639461..1643774 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1643775..1643839 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1643785..1644002 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1643785..1644002 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1643811..1643817 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1643832..1643843 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1643841..1643908 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1643841 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1643891..1643897 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1643910..1644103 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1643910 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1643911..1643930 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1644104..1644574 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1644104..1644574 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1644425) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1644609..1645724 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1644609..1645724 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1644671..1644771) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1644711) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1645738..1646013 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1645738..1646013 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1646015..1646317 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1646015..1646317 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1646337..1648487 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1646337..1648487 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1648382..1648388 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1648397 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1648403..1648421 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1648484..1648762 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1648484..1648762 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1648779..1649132 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1648779..1649132 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1649123 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1649214..1650143 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1649214..1650143 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1649928..1649935 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649949..1649968 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1649958 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1650162..1651112 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1650162..1651112 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1651145..1651151 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1651152..1651268 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1651152 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1651166..1651185 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1651269..1651538 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1651269..1651538 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1651521 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1651566..1651651 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1651632..1651635 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1651651..1651670 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1651653 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1651711..1653828 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1651711..1653828 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1653611 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1653812 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1653857..1653945 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1653946..1654905 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1653946..1654905 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1654014..1654022) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654017) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654036..1654043) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1654509..1654514 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654530..1654548 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1654535 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1654945..1656174 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1654945..1656174 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1656163 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1656203..1656208 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1656218 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1656224..1656242 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1656252..1656509 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1656252..1656509 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1656510..1656564 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1656537 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1656606..1656615 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1656625..1656694 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1656625 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1656629..1656648 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1656695..1657588 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1656695..1657588 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1657591..1658193 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1657591..1658193 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1658247..1658266 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1658247..1658318 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1658247 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1658319..1659359 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1658319..1659359 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1659360..1659450 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1659451..1660665 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1659451..1660665 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1660696..1661568 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1660696..1661568 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1661039..1662223) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1661575 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1661668..1661671 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1661685 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1661687..1661706 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1661746..1663413 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1661746..1663413 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1662210..1662228) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1662227) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1662244..1662249) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1663401 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1663468..1663474 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1663488..1663499 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1663489 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1663529..1664266 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1663529..1664266 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1664263..1664475 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1664263..1664475 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1664503..1664522 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1664517 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1664606..1666969 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1664606..1666969 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1666970..1667070 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1667031..1667038 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1667053..1667072 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1667071 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1667113..1667838 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1667113..1667838 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1667825 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1667894..1667900 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1667913 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1667915..1667926 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1667977..1669185 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1667977..1669185 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1669143 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1669254..1669261 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1669274..1669293 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1669296 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1669308..1669311 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669327..1669339 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669341 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1669365..1670645 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1669365..1670645 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1670642..1671928 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1670642..1671928 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1671778 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1671929..1671982 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1671983..1672711 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1671983..1672711 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1672727..1672733 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1672745 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1672747..1672758 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672758) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1672769..1672783) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1672792..1672796) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1672792..1673049 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1672792..1673049 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1673034 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1673066) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1673107..1673110 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1673125..1673144 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1673125 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1673179..1673694 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1673179..1673694 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1673630..1673968 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1673630..1673968 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1674035..1674901 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1674035..1674901 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1674098..1674198 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1674158 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1674861 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1674951..1675532 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1674951..1675532 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1675550..1676800 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1675550..1676800 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1676801..1676927 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1676907..1676914 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1676929..1676948 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1676929 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1676973..1678019 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1676973..1678019 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1678031 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1678076..1678141 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1678113..1678122 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1678135..1678150 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1678143 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1678187..1679362 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1678187..1679362 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1679363..1679462 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1679436..1679443 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1679457..1679476 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1679464..1679637 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1679464 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1679638..1681200 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1679638..1681200 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1681177 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1681269..1682063 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1681269..1682063 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1681818..1681823 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1681839..1681857 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1681859 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1682107..1682112 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1682123..1682262 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1682123 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1682128..1682146 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1682155) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1682166..1682179) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1682188..1682192) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1682199) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1682263..1682523 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1682263..1682523 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1682475 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1682507) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1682519 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1682564..1682738 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1682722..1682729 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1682740 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1682744..1682763 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1682789..1683832 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1682789..1683832 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1683845..1685023 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1683845..1685023 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1685005 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1685103..1685106 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1685115 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1685121..1685140 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1685171..1686700 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1685171..1686700 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1686702..1687133 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1686702..1687133 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1687116 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1687264..1687269 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1687285..1687303 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1687293..1687394 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1687293 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1687395..1687940 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1687395..1687940 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1687934 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1687941) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1687998..1688001 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688016..1688035 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688020 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1688073..1690649 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1688073..1690649 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1690665..1692548 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1690665..1692548 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1692451..1692945) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1692463 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1692473) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1692695..1692702 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1692717..1692736 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1692727..1692860 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1692727 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1692732..1692882) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1692732..1692882) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1692817 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1692946..1693401) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1692946..1693401) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1693402..1693493) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1693481..1693500) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693493) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693517..1693520) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1693556..1694113) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1693556..1694113) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" promotor_-35 1694197..1694204 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1694217..1694236 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1694219..1694237) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1694222 /Source="Nicolas_upshifts" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1694233) /Source="Nicolas_upshifts" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1694234..1694371 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /locus_tag="Delta6_BSU_17080-art" /modified_by="stephanmichalik" /transl_table=11 /pseudo /translation="MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLE A*" /label="Delta6_BSU_17080-art" gene 1694234..1694371 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /locus_tag="Delta6_BSU_17080-art" /label="Delta6_BSU_17080-art" promotor_-35 complement(1694252..1694257) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1694349,1695412) /created_by="User" /modified_by="User" /label="Delta5" N_region 1694350..1695411 /note="insertion of sequence with unknown origin - insert contains an independent promoter SD and chloramphenicol resistance gene" /created_by="User" /label="Delta5" promotor_-35 1694365..1694372 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1694568..1694573 /created_by="User" /label="Delta5_SigA_-35" promotor_-10 1694591..1694596 /created_by="User" /label="Delta5_SigA_-10" CDS 1694660..1695379 /gene="catA" /locus_tag="A8O17_RS08865" /old_locus_tag="A8O17_08865" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_032488880.1" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="type A chloramphenicol O-acetyltransferase" /modified_by="User" /translation="MNFNKIDLDNWKRKEIFNHYLNQQTTFSITTEIDISVLYRNIKQ EGYKFYPAFIFLVTRVINSNTAFRTGYNSDGELGYWDKLEPLYTIFDGVSKTFSGIWT PVKNDFKEFYDLYLSDVEKYNGSGKLFPKTPIPENAFSLSIIPWTSFTGFNLNINNNS NYLLPIITAGKFINKGNSIYLPLSLQVHHSVCDGYHAGLFMNSIQELSDRPNDWLL*Y EIMPTVLFTVGFLMSLTCPVS*" /label="Delta6_NEW_001" gene 1694660..1695379 /gene="catA" /locus_tag="A8O17_RS08865" /old_locus_tag="A8O17_08865" /pseudo /modified_by="User" /label="Delta6_NEW_001" CDS 1695412..1695894 /note="pseudogene - residual C-terminal sequence due to internal deletion scar" /created_by="AR/SM" /locus_tag="Delta6_pseudo_BSU_17220" /modified_by="stephanmichalik" /transl_table=11 /pseudo /translation="EFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLESYTVK PLPDPETVKCYYFRNKSRSFFGDLDTYFTLSNEKEPFDQAAYWEEWERQIPHFHLVDV DSSNHFMILTEPKASTALLEFCEKLYSNRGVVNANFLKAFRKKHEAREEKETDELVKR *" /label="Delta6_pseudo_BSU_17220" gene 1695412..1695894 /note="pseudogene - residual C-terminal sequence due to internal deletion scar " /created_by="AR/SM" /modified_by="User" /locus_tag="Delta6_pseudo_BSU_17220" /label="Delta6_pseudo_BSU_17220" downshifts 1695883 /Source="Nicolas_upshifts" /id="D927" /incds=0 /nref=65 /ntot=216 /MaxReadThrough="0.92789" /MaxDrop="5.77685" /score="4.87908333" /energy="-14.6" /TU="NA" /idTUdmin="U1370" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1695939..1697156) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 17482575, 16707694, 17234808, 17886826, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 of bacillaene metabolism" /protein_id="NP_389605.2" /db_xref="EnsemblGenomes-Gn:BSU17230" /db_xref="EnsemblGenomes-Tr:CAB13607" /db_xref="GOA:O31785" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4YZR" /db_xref="SubtiList:BG12655" /db_xref="UniProtKB/Swiss-Prot:O31785" /translation="MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPA WLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRL RSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVH AEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILN INRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF LRGLESLPVSLSK*" /label="pksS CDS" gene complement(1695939..1697156) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /label="pksS gene" downshifts complement(1695958) /Source="Nicolas_upshifts" /id="D928" /incds=0 /nref=123 /ntot=225 /MaxReadThrough="0.911470000000001" /MaxDrop="4.23567" /score="16.9796453" /energy="-16.8" /TU="NA" /idTUdmin="U1373" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(1697171..1697271) /Source="Nicolas_upshift_promotors" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1697211) /Source="Nicolas_upshifts" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1697243..1697262) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697255) /Source="Nicolas_upshifts" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1697257..1697337) /Source="Nicolas_S_feature" /locus_tag="new_1859884_1859964_c" /HighExp="Salt, Etha, T-3.40H, T-0.40H, T-1.40H, LoTm, T-2.40H, S1, SMM, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.122" /TUlongSig="NA" /TUlongPSig="NA" /label="S618" promotor_-35 complement(1697277..1697284) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1697381) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1697387..1697743) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1697387..1697743) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1697803..1697816) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1697808) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1697822..1698646) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1697822..1698646) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1698668..1698687) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1698684) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1698699..1698705) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1698757..1700085) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1698757..1700085) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1698764) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1700108..1700127) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1700127) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700141..1700149) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1700242..1700249 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1700257..1700276) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1700265..1700284 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1700268) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1700271 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700289..1700296) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1700310..1700387 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1700310..1700387 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1700312) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1700365..1700541 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1700365..1700541 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1700522 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1700567..1700755 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1700750..1700769 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1700757 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1700821..1701528 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1700821..1701528 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1701539..1701545 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1701559..1701578 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1701563 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1701598..1702050 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1701598..1702050 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1702038 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1702064..1702417) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1702064..1702417) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1702105) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1702431..1702748) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1702431..1702748) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1702792..1702811) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1702800) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1702826..1702833) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1702885..1703160) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1702885..1703160) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1702886) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1703156..1703161 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1703177..1703195 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1703187..1703206) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1703197 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1703200) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1703219..1703228) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1703249..1703662 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1703249..1703662 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1703713 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1703719..1703738 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1703762..1704706 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1703762..1704706 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1704686..1704694 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1704705..1704723 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1704707 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1704746..1704967 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1704746..1704967 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1704757) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1704819..1704823) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704823) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1704838..1704843) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1704967 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1705163..1705435 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1705163..1705435 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1705451..1705458 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705472..1705491 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705474 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1705517..1705747 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1705517..1705747 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1705748..1705824 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1705781 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1705826..1705933 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1705906..1705913 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705927..1705946 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705935 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1705990..1706382 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1705990..1706382 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1706342..1708444 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1706342..1708444 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1708462..1709451 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1708462..1709451 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1709411 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1709465..1710124) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1709480) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1709501..1710121 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1709501..1710121 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1710102 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1710137..1710141 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1710159..1710526 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1710159 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1710163..1710180 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1710169) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1710185..1710952) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1710185..1710952) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1710961..1710980) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1710984) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1710993..1711002) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1711106..1711111 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1711127..1711145 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1711127 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1711409..1711414 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1711431..1711449 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1711435..1711575 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1711435 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1711576..1712544 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1711576..1712544 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1712513 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1712608..1712616 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1712623 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1712627..1712646 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1712677..1713939 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1712677..1713939 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1713957..1715222 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1713957..1715222 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1715270..1715277 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1715292..1715311 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1715304 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1715332..1715739 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1715332..1715739 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1715338) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1715720..1715738 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1715745 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1715798) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1715798..1717132 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1715798..1717132 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1717109 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1717154..1717414 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" promotor_-35 1717389..1717396 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1717411..1717430 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1717416 /Source="Nicolas_upshifts" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1717460..1717750 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective, phage region" /protein_id="NP_389629.1" /db_xref="EnsemblGenomes-Gn:BSU17470" /db_xref="EnsemblGenomes-Tr:CAB13631" /db_xref="GOA:P31844" /db_xref="SubtiList:BG11074" /db_xref="UniProtKB/Swiss-Prot:P31844" /translation="MKKLTIFSGGLGAVFSVLAQLFAVIDDSYTLGNLWFLGALAGII TMLASIQTNNKPVFSILLIASSVIGLLGTGLVYIIPTLFNIIIIYKFSKVSQ*" /label="ynxB CDS" gene 1717460..1717750 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /label="ynxB gene" S_feature 1717751..1717995 /Source="Nicolas_S_feature" /locus_tag="new_1880378_1880622" /HighExp="Cold, M9-stat, BC, B60, LPhT, T0.30H, LBGstat, LoTm, S4, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49198399999999998" /TUshortSig="SigA, SigL, SigA" /TUshortPSig="0.997, 0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S626" CDS 1717996..1718340 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389630.1" /db_xref="EnsemblGenomes-Gn:BSU17480" /db_xref="EnsemblGenomes-Tr:CAB13632" /db_xref="SubtiList:BG13469" /db_xref="UniProtKB/Swiss-Prot:O31799" /translation="MWKALSQLLKKQKNQSPSDEDYIQIPELEVKVLGMLHSINIDLV NVIAQAEKSKEFIGQIEGIWHSIANQFYSLAQGFENEDINKLSADLDHAAATWEAVAN KAKEFVTNSYQG*" /label="ynzF CDS" gene 1717996..1718340 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /label="ynzF gene" downshifts 1718318 /Source="Nicolas_upshifts" /id="D947" /incds=0 /nref=31 /ntot=125 /MaxReadThrough="3.06401" /MaxDrop="4.27622" /score="-0.54122646" /energy="-8.3" /TU="U1394,U1396" /idTUdmin="U1394" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1718471..1718722 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389631.1" /db_xref="EnsemblGenomes-Gn:BSU17490" /db_xref="EnsemblGenomes-Tr:CAB13633" /db_xref="SubtiList:BG13470" /db_xref="UniProtKB/Swiss-Prot:O31800" /translation="MLGINVEKSNENLIINWQLSKIEIPIKEINDVFLDPNYGGEEKS AVRIGFPYGSTDRVVIKTARNTYILFTTNPALIMSKIVS*" /label="ynzG CDS" gene 1718471..1718722 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /label="ynzG gene" promotor_-35 1718748..1718755 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1718766..1718785 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1718779..1718908 /Source="Nicolas_S_feature" /locus_tag="new_1881406_1881535" /HighExp="LoTm, Etha, LPhT, B60, M9-stat, T3.0H, T3.30H, Salt, T4.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.968584" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.997, 1, 1" /label="S627" upshifts 1718779 /Source="Nicolas_upshifts" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1718909..1719343 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /function="17.2: Prophage functions" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389632.2" /db_xref="EnsemblGenomes-Gn:BSU17500" /db_xref="EnsemblGenomes-Tr:CAB13634" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG12254" /db_xref="UniProtKB/Swiss-Prot:P94480" /translation="MEDATFHFKDPASPQEISDIEQKLGVTFPNDYKEFLLQHNGMEM FDGIEILSLEGIIEYNEVQDFPEGYVLIGYHFDGRYVIDTNKSKNGLGYMLYLDSIDD IEDAINLDSNFEIWFDMLVSLNGTKYWEVNPNLQEYYKLVSE*" /label="ynaB CDS" gene 1718909..1719343 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /label="ynaB gene" CDS 1719413..1720204 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389633.1" /db_xref="EnsemblGenomes-Gn:BSU17510" /db_xref="EnsemblGenomes-Tr:CAB13635" /db_xref="SubtiList:BG12255" /db_xref="UniProtKB/Swiss-Prot:P94481" /translation="MTIYEQIKDALKNKINELVSPQEVKKTLQEKYGTNPDSIILSDY CYNRYNKGISFNKHLFEYMNRSSYKYLGENSLYTGLIFRKSKGEDKEVIVGEWVNGVK SLREASVTNNQINDQAEIISKEQLVNLYNEYNQILRYEMNVLNCKPTELRHLIGRIGE FICAIQTNGTLARQTNQHGFDVVSDGRRISVKTTAQSSGFISINKNTFYDFDDFFVVQ YVNDDFKVIFFGSKEEVQKISRIYGSQYEVEISLLKKLNKEYQLN*" /label="ynaC CDS" gene 1719413..1720204 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /label="ynaC gene" promotor_-10 complement(1719521..1719540) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1719529) /Source="Nicolas_upshifts" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1719556..1719558) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1720200 /Source="Nicolas_upshifts" /id="D948" /incds=0 /nref=10 /ntot=182 /MaxReadThrough="4.47202" /MaxDrop="6.29359" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" downshifts 1720266 /Source="Nicolas_upshifts" /id="D949" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="3.36892" /MaxDrop="4.40772" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1720477..1720485 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1720497..1720515 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1720508 /Source="Nicolas_upshifts" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1720539..1721051 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase; putative phage region" /protein_id="NP_389634.1" /db_xref="EnsemblGenomes-Gn:BSU17520" /db_xref="EnsemblGenomes-Tr:CAB13636" /db_xref="GOA:P94482" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12256" /db_xref="UniProtKB/Swiss-Prot:P94482" /translation="MHITTKRLLIREFEFKDWQAVYEYTSDSNVMKYIPEGVFTEEDA KAFVNKNKGDNAEKFPVILRDEDCLIGHIVFYKYFGEHTYEIGWVFNPNYQNKGYASE AAQAILEYGFKEMNLHRIIATCQPENIPSYRVMKKIGMRREGFFKKCIPKGNEWWDEY YYAILEEEWN*" /label="ynaD CDS" gene 1720539..1721051 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /label="ynaD gene" promotor_-35 1721498..1721504 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1721498 /Source="Nicolas_upshifts" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1721500..1721504 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1721518..1721537 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1721518..1721537 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1721542..1721610 /Source="Nicolas_S_feature" /locus_tag="new_1884169_1884237" /HighExp="T1.30H, M9-stat, Lbtran, M0t90, T0.30H, T1.0H, T2.30H, Lbstat, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S628" upshifts 1721542 /Source="Nicolas_upshifts" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="upshifts" CDS 1721611..1722252 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389635.1" /db_xref="EnsemblGenomes-Gn:BSU17530" /db_xref="EnsemblGenomes-Tr:CAB13637" /db_xref="InterPro:IPR024976" /db_xref="SubtiList:BG12257" /db_xref="UniProtKB/Swiss-Prot:P94483" /translation="MNLIGYIEERFQNLELIPSIYNQWGTGIHFCLGENIYQLKANEE LNLKMFRIVYEQTSIIFNELFEQNDDIFLVTNMYKHKKKEKCIRKLKVYQPFLKCKNH LNQIMVKTYPYPFEINKAEEYEMQQFSLLCKPRDLRVTELLKAASNEDFPQKPKFGGY SIDYPDVFFVNITKDIIFFIYDDRGCEVIAHDFKRIRPLYEKYHDWVEEYKCM*" /label="ynaE CDS" gene 1721611..1722252 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /label="ynaE gene" S_feature 1722253..1722340 /Source="Nicolas_S_feature" /locus_tag="new_1884880_1884967" /HighExp="M0t90, Lbtran, Lbstat, T1.30H, S2, T1.0H, T0.30H, MG 150, M9-stat, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S629" CDS 1722341..1722694 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389636.1" /db_xref="EnsemblGenomes-Gn:BSU17540" /db_xref="EnsemblGenomes-Tr:CAB13638" /db_xref="SubtiList:BG12258" /db_xref="UniProtKB/Swiss-Prot:P94484" /translation="MVLCDDERSAFLLVLDERLVDFDSQGGNHISVYLVTHFELSDQS YKDVLSFNDDLLGMEHNCSYAMDILSVKEELDFDFPFNMLAIKSYVQELIKMLGIDIT LPEMKERDFDKLSQN*" /label="ynaF CDS" gene 1722341..1722694 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /label="ynaF gene" CDS 1722738..1723013 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389637.1" /db_xref="EnsemblGenomes-Gn:BSU17550" /db_xref="EnsemblGenomes-Tr:CAB13639" /db_xref="GOA:P94485" /db_xref="SubtiList:BG12259" /db_xref="UniProtKB/Swiss-Prot:P94485" /translation="MNVKKAAAVFSITIPIISAILIINFFTGFMSIPWQGMPVFFPLL LSPIGIILAFVSIKTNKRCAVYGIVLNAIMFPFPFFWFIGGALLFGV*" /label="ynaG CDS" gene 1722738..1723013 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /label="ynaG gene" downshifts complement(1723114) /Source="Nicolas_upshifts" /id="D950" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="1.74772" /MaxDrop="3.30031" /score="-7.48025946" /energy="-14.4" /TU="NA" /idTUdmin="U1402" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 1723126..1723290 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="YP_003097730.1" /db_xref="EnsemblGenomes-Gn:BSU17559" /db_xref="EnsemblGenomes-Tr:CAX52623" /db_xref="GOA:C0H415" /db_xref="UniProtKB/Swiss-Prot:C0H415" /translation="MDRKKDEIQRKYREQMREKKEREKEDGSSHTFEIVVVLAIIILM FFFNSVFKAF*" /label="ynzI CDS" gene 1723126..1723290 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /label="ynzI gene" S_feature 1723291..1723429 /Source="Nicolas_S_feature" /locus_tag="new_1885918_1886056" /HighExp="M0t90, Lbstat, S1, Lbtran, S2, M40t90, T1.30H, Glu, T1.0H, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S630" CDS 1723430..1723900 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389638.3" /db_xref="EnsemblGenomes-Gn:BSU17560" /db_xref="EnsemblGenomes-Tr:CAB13640" /db_xref="SubtiList:BG12261" /db_xref="UniProtKB/Swiss-Prot:P94487" /translation="MKLYNEFINIAKTFNKELDIIPLLYGSLGLEKVTGLDFSPEDID LLIPLIFLEEKWEKLKKVMELHGYKMVDLHEHEFKKTNTKIGISYIEDLKPFADVDYN NLEIFEDGGAKYHLLTIDDYLKIYKKSLLDGYRRRKKNHKDQSKINILNKLIRN*" /label="ynaI CDS" gene 1723430..1723900 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /label="ynaI gene" S_feature 1723901..1724724 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1724064..1724082) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1724082) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1724098..1724103) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1724725..1726116 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1724725..1726116 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1726147..1727748 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1726147..1727748 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1726263..1726568) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1726563..1726582) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726568) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1726596..1726604) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1727746 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1727885..1729039) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1727885..1729039) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1727888) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1728938..1729116) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1729084..1729090 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1729099..1729118) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1729100..1729116 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1729110 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1729116) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1729133..1729136) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1729143..1729150 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729165..1729184 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1729176..1729280 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1729177 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1729281..1730618 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1729281..1730618 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1730619..1730693 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1730650 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1730769..1732268 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1730769..1732268 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1732269..1732584 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1732542 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1732751..1733386) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1732751..1733386) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1733423..1733442) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733432) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733457..1733464) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1733574..1733581 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733596..1733615 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1733598..1733796 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1733598 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1733797..1735212 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1733797..1735212 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1735202 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1735305) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1735314..1736498) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1735314..1736498) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1736499..1736578) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1736571..1736589) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1736582) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1736605..1736610) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1736890..1736897 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1736912..1736931 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1736920 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1736962..1737423 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1736962..1737423 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1737453..1737887 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1737453..1737887 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1737636..1737941) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1737734 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1737888..1738984 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1737943..1738228) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1737986) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1738223..1738242) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738228) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738254..1738259) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1738490) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1738490..1738750) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1738490..1738750) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1738771..1738790) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738781) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738803..1738812) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1738985..1739110 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1738985..1739110 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1739111..1739227 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1739154..1739318 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1739154..1739318 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1739202..1739211 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1739225..1739244 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1739229..1739539 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1739229 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1739520..1739527 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1739541..1739560 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1739541 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1739592..1740431 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1739592..1740431 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1739614..1739633) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1739635) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1739648..1739651) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1740391 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1740537) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1740538..1740844) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1740554..1740841) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1740554..1740841) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1740581) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1740668..1740676 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1740690..1740709 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1740692 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1740703..1740863 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1740835 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1740884..1741606) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1740884..1741606) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1740889) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1741631..1741650) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1741639) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1741641..1741765) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1741766..1742122) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1741766..1742122) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1742146..1742165) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742163) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742181..1742185) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1742362) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1742368..1742568) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1742368..1742568) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1742551 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1742590..1742609) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742602) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742622..1742631) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1742743..1742931) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1742743..1742931) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1742759) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1742900..1742907) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1742913) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1742960..1742979) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742978) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742994..1743001) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1743010..1743147 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1743010..1743147 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1743041..1743046 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1743061..1743079 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1743079..1743181 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1743079 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1743182..1743580 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1743182..1743580 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1743581..1744385 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1743645..1744079) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1743645..1744079) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1743661) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1744109..1744128) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744125) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1744142..1744149) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1744386..1744574 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1744386..1744574 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1744575..1744660 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1744619 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1744689..1744695 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1744707..1744866 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1744707 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1744709..1744720 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1744867..1746429 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1744867..1746429 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1745170..1745189) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745179) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745204..1745211) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1746459..1747550 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1746459..1747550 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1747540..1748754 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1747540..1748754 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1748832..1748839 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1748854..1748873 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1748865 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1748901..1749707 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1748901..1749707 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1749515..1750613) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1749712..1750329 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1749712..1750329 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1750326..1751966 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1750326..1751966 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1750600..1750619) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750613) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750633..1750641) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1751606..1752372) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1752003..1752368 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1752003..1752368 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1752345 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1752365..1752645) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1752365..1752645) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1752374..1752505) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1752417) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1752465..1752474 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1752487..1752496) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1752488..1752507 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1752493 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1752495..1752593 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1752505) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1752507..1752637) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1752594..1753352 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1752594..1753352 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1752627 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1752643..1752662) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752644) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1752677..1752684) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1753167..1753378) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1753331 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1753376..1753995 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1753379..1753918) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1753379..1753918) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1753919..1753933) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753925) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753947..1753953) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1753973..1753982 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753995..1754010 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753997 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1754036..1754470 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1754036..1754470 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1754328..1754675 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1754328..1754675 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1754471..1754803 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1754762..1754771 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1754783..1754798 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1754805..1754983 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1754805 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1754874..1754953 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1754874..1754953 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1754940 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1755012..1755629) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1755012..1755629) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1755013) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1755653..1755672) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755674) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755686..1755693) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1755709..1755716 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1755728 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1755730..1755749 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1755779..1756096 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1755779..1756096 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1755796..1755814) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755799) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755828..1755835) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1756115..1756768 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1756115..1756768 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1756771..1756778 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1756792..1756811 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1756805 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1756832..1757065 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1756832..1757065 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1757066..1757201 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1757169..1757176 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1757190..1757209 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1757203 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1757234..1759237 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1757234..1759237 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1757438..1757457) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1757455) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1759227 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1759239..1759897) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1759337 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1759338..1759357 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1759390..1759836 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1759390..1759836 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1759860..1759879 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1759868 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1759879..1759896) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1759897) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1759915..1759919) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1759922..1760140 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1759922..1760140 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1760152 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1760197..1760496 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1760214..1760387) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1760214..1760387) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1760227) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1760425..1760444) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760432) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1760458..1760465) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1760467..1760475 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1760487..1760506) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1760487..1760505 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1760498..1760606 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1760498 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1760499) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1760521..1760528) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1760607..1761314 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1760607..1761314 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1761334..1761341 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1761353..1761372 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1761361 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1761403..1761765 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1761403..1761765 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1761783..1761786 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1761801..1761820 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1761812 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1761844..1762335 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1761844..1762335 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1762331 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1762366..1762794) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1762366..1762794) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1762383) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1762812..1762831) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762824) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1762826..1762911) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1762845..1762852) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1762882..1762891 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1762901..1763010 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1762901 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1762904..1762923 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1762906..1762925) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762911) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1762913..1762996) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1762940..1762943) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1762967 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1763028..1763420) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1763028..1763420) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1763041) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1763263..1763268 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1763284..1763302 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1763288 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1763398..1763402 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1763412..1763426 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1763427..1763446) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1763429 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1763442) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1763460..1763469) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1763501..1763647) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1763501..1763647) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1763522) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1763679..1763825) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1763679..1763825) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1763825..1763958 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1763825 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1763836..1763838 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1763841..1763852) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1763855) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1763867..1763873) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1763948..1763955 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1763960..1764052 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1763960 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1763970..1763989 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1764011) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1764053..1766782 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1764053..1766782 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1764073..1764077) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1764077) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1766783..1766853 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1766854..1767366 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1766854..1767366 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1767323 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1767392..1767398 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1767411 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1767413..1767424 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1767447..1767572 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1767447..1767572 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1767465) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1767586..1767592 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1767607..1767618 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1767609 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1767637..1767783 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1767637..1767783 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1767820..1768071 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1767820..1768071 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1768049 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1768092..1768097 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1768111..1768130 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1768115..1768206 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1768115 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1768207..1768572 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1768207..1768572 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1768588..1768887 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1768588..1768887 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1768863 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1768918..1769205) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1768918..1769205) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1768939) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1769005) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1769235..1769254) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769247) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769270..1769277) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1769293..1769874) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1769293..1769874) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1769875..1770005 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1769900..1769919) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1769917) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1769990..1769993 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1770007 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1770009..1770028 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1770044..1770451 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1770044..1770451 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1770447 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1770513..1770516 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1770531..1770550 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1770535..1770849 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1770535 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1770850..1772817 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1770850..1772817 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1772821..1775241 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1772821..1775241 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1775221 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1775249..1775438) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1775288..1775464) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1775288..1775464) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1775292) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1775439..1775849) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1775439..1775849) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1775822..1775841) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775825) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1775856..1775863) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1775890..1775909) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775891) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1775924..1775931) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1775938..1775957) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775949) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1775971..1775980) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1776197..1776202 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1776215..1776234 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776220 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1776233..1776297 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1776298..1777695 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1776298..1777695 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1777684 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1777729 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1777785..1778531) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1777908..1777915 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1777927 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1777928..1777947 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1777998..1779497 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1777998..1779497 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1778530..1778549) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778553) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1778563..1778572) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1779445 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1779565..1779828 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1779565..1779828 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1780087) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1780087..1781355) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1780087..1781355) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1781356..1781485) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1781486..1783027) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1781486..1783027) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1783028..1783349) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1783339..1783358) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1783350) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1783373..1783376) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1783576..1783583 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1783596..1783615 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1783603 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1783622..1784068 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1783622..1784068 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1784075..1784968 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1784075..1784968 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1784585..1784604 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1784593 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1785041..1785637 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1785041..1785637 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1785627 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1785686..1786885) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1785686..1786885) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1786886..1786957) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1786945..1786956) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786957) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1786971..1786977) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1787055..1788590) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1787055..1788590) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1787067) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1788601..1789383) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1788601..1789383) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1789404..1790303) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1789404..1790303) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1790318..1790539) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1790318..1790539) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1790554..1791888) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1790554..1791888) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1791898..1793547) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1791898..1793547) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1791947..1792047 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1792007 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1793591..1794733) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1793591..1794733) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1794752..1794770) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794769) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1794786..1794791) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1794824..1795129) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1794824..1795129) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1795119..1795292) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1795119..1795292) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1795400..1796932) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1795400..1796932) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1795411) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1796967..1796986) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1796967) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1796999..1797008) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1797068..1797460) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1797068..1797460) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1797099) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1797488..1797499) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1797495) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1797513..1797519) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1797571..1801410) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" /label="ppsE CDS" gene complement(1797571..1801410) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /label="ppsE gene" downshifts complement(1797583) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS complement(1801418..1812229) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" /label="ppsD CDS" gene complement(1801418..1812229) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /label="ppsD gene" promotor_-35 1804438..1804441 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1804458..1804477 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1804459 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1812254..1819921) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" /label="ppsC CDS" gene complement(1812254..1819921) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /label="ppsC gene" CDS complement(1819938..1827620) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" /label="ppsB CDS" gene complement(1819938..1827620) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /label="ppsB gene" downshifts complement(1823609) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" /label="downshifts" upshifts complement(1823653) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1823655..1823659) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1823677..1823680) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1823956..1823960 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1823973 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1823976..1823995 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1827645..1835330) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" /label="ppsA CDS" gene complement(1827645..1835330) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /label="ppsA gene" S_feature complement(1835331..1835439) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1835424..1835443) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1835439) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1835457..1835464) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1835713..1837188) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1835713..1837188) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1835725) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1837222..1838199) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1837222..1838199) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1838228..1838246) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838240) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838258..1838266) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1838333..1839724) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1838333..1839724) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1838347) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1838493 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1839514..1839520 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1839534..1839552 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1839545..1839878 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1839545 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1839725..1839829) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1839789..1839889) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1839829) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1839851..1839856 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1839872..1839890 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1839880 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1839938..1839945 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1839958..1839977 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1839961 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1840010..1840555 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1840010..1840555 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1840539 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1840649..1840721) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1840649..1840721) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1840747) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1840774..1841319) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1840774..1841319) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1841359..1841378) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841373) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841392..1841399) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1841635..1841865) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1841635..1841865) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1841649) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1841891..1841910) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841903) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841922..1841928) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1841957..1841976) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1841967) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1841980..1841987 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1842001..1842020 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1842005 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1842050..1843813 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1842050..1843813 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1843794 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1843914..1844771) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1843914..1844771) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1844817..1844836) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844837) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1844850..1844857) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1844899..1845888 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1844899..1845888 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1844955..1845913) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1845945..1847426) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1845945..1847426) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1845958) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1847443..1852005) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1847443..1852005) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1850466..1850566 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1850526 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1852006..1852077) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1852057..1852076) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1852074..1852081 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1852077) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1852091..1852098) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1852093 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1852096..1852115 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1852152..1853054 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1852152..1853054 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1853034 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1853106..1854221) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1853106..1854221) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1854218..1855111) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1854218..1855111) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1855116..1855135) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1855124 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1855134) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855149..1855155) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1855164..1855182) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855182) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855198..1855203) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1855259..1855627) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1855259..1855627) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1855662..1855680) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1855685) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1855687..1855806) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1855692..1855700) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1855798..1855817) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855806) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1855808..1855904) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1855832..1855839) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1855927..1856643) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1855927..1856643) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1855949) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1856681..1856700) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1856690) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1856716..1856719) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1856744..1856750 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1856764..1856782 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1856769 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1856794..1857099 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1856794..1857099 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1857083 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1857170..1857940 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1857170..1857940 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1857922..1857929 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1857941 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1857944..1857963 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1857984..1858517 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1857984..1858517 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1858518..1858603 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1858560 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1858596..1859840) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1858596..1859840) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1858605..1859344 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1858610) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1859841..1859933) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1859934..1861397) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1859934..1861397) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1861415..1862449) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1861415..1862449) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1862461..1862532) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1862504) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1862533..1862624) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1862533..1862624) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1862652..1862671) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1862664) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1862686..1862693) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1862706..1862713 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1862727..1862746 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1862731 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1862773..1864815 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1862773..1864815 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1864823..1864832 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1864845..1864860 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1864848 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1864882..1865175 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1864882..1865175 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1865155 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1865200..1865547) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1865231) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1865548..1865952) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1865548..1865952) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1865953..1866048) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1866038..1866053) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1866038..1866157) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1866038..1866157) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1866048) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866066..1866075) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1866153..1866159 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1866173..1866184 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1866184..1866392 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1866184 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1866227..1866349 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1866227..1866349 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1866393..1866686 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1866393..1866686 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1866687..1866780 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1866737 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1866802..1868487) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1866802..1868487) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1866814) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1868488..1868575) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1868567..1868585) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1868575) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1868599..1868606) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1868744..1868753 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1868763 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1868766..1868785 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1868812..1870263 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1868812..1870263 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1870239 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1870300..1870998) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1870300..1870998) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1870315) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1871033..1871052) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1871052) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1871054..1871267) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1871066..1871073) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1871268..1871945) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1871268..1871945) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1871946..1874435) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1872118..1873155 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1872118..1873155 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1873352..1873358 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873373..1873384 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1873385 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1873412..1874095 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1873412..1874095 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1874436..1874741) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1874436..1874741) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1874742..1874843) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1874822..1874841) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1874843) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1874856..1874863) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1874871..1874973) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1874913) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1874974..1876152) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1874974..1876152) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1876178..1876197) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1876197) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1876211..1876220) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1876275..1876763) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1876275..1876763) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1876300) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1876788..1876943) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1876788..1876943) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1876983..1877738) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1876983..1877738) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1877991..1877996 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1878012..1878030 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1878027 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1878046..1878402 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1878046..1878402 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1878361..1878600) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1878361..1878600) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1878403..1878839 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1878601..1878702) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1878703..1879200) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1878703..1879200) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1879201..1879300) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1879301..1880212) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1879301..1880212) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1880234..1880245) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1880236) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1880260..1880266) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1880496..1880503 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1880512 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1880518..1880537 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1880559..1881041 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1880559..1881041 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1881051..1881305 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1881051..1881305 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1881306..1881410 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1881411..1882205 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1881411..1882205 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1882206..1883216 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1882329..1883201) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1882329..1883201) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1883302..1884180 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1883302..1884180 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1884293..1884352) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1884328) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1884353..1884784) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1884353..1884784) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1884804..1884823) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884812) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1884814..1885047) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1884837..1884843) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1885048..1885066) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1885048..1885680) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1885048..1885680) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1885054) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1885082..1885087) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1885818..1885825 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1885840..1885859 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1885844 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1885906..1886826 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1885906..1886826 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1886337..1886356) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886352) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1886371..1886378) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1886827..1887484 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1887323..1887685) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1887323..1887685) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1887746..1887958) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1887746..1887958) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1887997..1888004 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1888019..1888038 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1888022 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1888062..1888325 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1888062..1888325 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1888303 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1888702..1891302) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1888702..1891302) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1891303..1891412) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1891328..1891335 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1891350..1891369 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1891358..1891985 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1891358 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1891402..1891421) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1891412) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1891436..1891442) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1891458..1891917) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1891500) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1891962) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1891972..1892613) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1891972..1892613) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1892614..1892731) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1892708..1892727) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892731) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1892741..1892743) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1893241..1893480) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097736.1" /db_xref="EnsemblGenomes-Gn:BSU18849" /db_xref="EnsemblGenomes-Tr:CAX52631" /db_xref="GOA:C0H423" /db_xref="InterPro:IPR007829" /db_xref="UniProtKB/Swiss-Prot:C0H423" /translation="MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGI PSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA*" /label="yozV CDS" gene complement(1893241..1893480) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /label="yozV gene" downshifts complement(1893261) /Source="Nicolas_upshifts" /id="D1030" /incds=0 /nref=31 /ntot=127 /MaxReadThrough="3.22282" /MaxDrop="3.97488" /score="-1.08247697" /energy="-4.5" /TU="U1526" /idTUdmin="U1526" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" misc_feature complement(1893520..1893539) /Source="Nicolas_upshift_promotors" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1893527) /Source="Nicolas_upshifts" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="upshifts" promotor_-35 1893586..1893593 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1893608..1893627 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1893615 /Source="Nicolas_upshifts" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="upshifts" CDS 1893651..1893989 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10376821" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="transcriptional regulator (phage-related, Xre family); putative defective prophage 6" /protein_id="NP_389766.1" /db_xref="EnsemblGenomes-Gn:BSU18850" /db_xref="EnsemblGenomes-Tr:CAB13777" /db_xref="GOA:O34647" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG13497" /db_xref="UniProtKB/Swiss-Prot:O34647" /translation="MYCQRLRQLRKAHKLTMEQLAEKIGIAKSSYGGYEAESKKPPLD KLVILARLYDVSVDYILGLTDDPDPKVERKNLKEFLEKPDIHWDGYKLTPEILDPIRK ILKLVTANNN*" /label="yobD CDS" gene 1893651..1893989 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /label="yobD gene" S_feature 1893990..1894586 /Source="Nicolas_S_feature" /locus_tag="new_2056617_2057213" /HighExp="M0t90, Lbstat, Lbtran, MG 150, M40t90, MG 15, SMM, GM 25, Fru, GM-0.1" /AntisenseName="yozH" /AntisenseCor="0.41013265801279702" /AntisenseRegPval="-11.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S711" CDS complement(1894023..1894379) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="NP_389767.2" /db_xref="EnsemblGenomes-Gn:BSU18860" /db_xref="EnsemblGenomes-Tr:CAB13778" /db_xref="SubtiList:BG13755" /db_xref="UniProtKB/Swiss-Prot:O31837" /translation="MNDLLFAAGNLHIGLGHDYLKCIALLINVKRFFSLTESYGNISD KLAVVAMKGVQFDQFEEAYKAYKETVAINQNSLVDFLSALITLIKAGEKLQKAGESLA IIMNKLLEMSPENSMK*" /label="yozH CDS" gene complement(1894023..1894379) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /label="yozH gene" CDS 1894587..1894952 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative defective prophage 6" /protein_id="NP_389768.1" /db_xref="EnsemblGenomes-Gn:BSU18870" /db_xref="EnsemblGenomes-Tr:CAB13779" /db_xref="SubtiList:BG13756" /db_xref="UniProtKB/Swiss-Prot:O31838" /translation="MPKLYTCLICGYKGLIQNPLNNDGEYQKTFDICPCCDFEYGYSE DHDVSLGFIVTPDYLIDAAIQLYRKQWIENGMKTANPEDIPEELRNGDCLKFEVLLKQ LNSLNLDTENFEIKGFNGY*" /label="yozI CDS" gene 1894587..1894952 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /label="yozI gene" S_feature complement(1894961..1896087) /Source="Nicolas_S_feature" /locus_tag="new_2057588_2058714_c" /HighExp="BC, Sw, HiOs, C90, Lbstat, M0t90, UNK1, M9-stat, HiTm, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig="0.994" /label="S712" downshifts complement(1895004) /Source="Nicolas_upshifts" /id="D1031" /incds=0 /nref=3 /ntot=99 /MaxReadThrough="3.80479" /MaxDrop="4.2268" /score="22.3776508" /energy="-7.6" /TU="U1528" /idTUdmin="U1528" /TUdmin="-513" /isTUend="FALSE" /label="downshifts" CDS 1895174..1895833 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative SOS response associated phage protein; putative defective prophage 6" /protein_id="NP_389769.1" /db_xref="EnsemblGenomes-Gn:BSU18880" /db_xref="EnsemblGenomes-Tr:CAB13780" /db_xref="GOA:O34915" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13498" /db_xref="UniProtKB/Swiss-Prot:O34915" /translation="MCGKFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTI INDGSNNRLGKLRWGLIPPCAKDEKIGYKMINARAETLAEKPSFRKPLGSKRCIIPAD SFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTLEGNLLYTCTIITIKPSELME DIHDRMPVILTDENKKEWLNPKNTDPDYLQSLLLPYDADDMEAYQVSSLVNSPELIES H*" /label="yobE CDS" gene 1895174..1895833 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /label="yobE gene" downshifts 1895911 /Source="Nicolas_upshifts" /id="D1032" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="1.22982" /MaxDrop="2.96245" /score="5.95470205" /energy="-19.6" /TU="NA" /idTUdmin="U1527" /TUdmin=990 /isTUend="FALSE" /label="downshifts" CDS complement(1896088..1897011) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389770.1" /db_xref="EnsemblGenomes-Gn:BSU18890" /db_xref="EnsemblGenomes-Tr:CAB13781" /db_xref="SubtiList:BG13499" /db_xref="UniProtKB/Swiss-Prot:O34780" /translation="MLVYIGNGHYCYSNSTAMFLSSIGENVSPQLVEILTGVGLGAMI EYEKNLYFSMRDPDDGINYALNILGFTAEEHQQASDLDDPFPLLKQQIKQNPVILGPL DMGELTYHPNHKNLNGSDHYVLGYQMDNENIYVQDPAGFPFVPLSLDQFKKAWMAERI PYRKGINKYWSTAKKVVTLDNNEIYERAIDYFKRTYRKFEKVDIGLIGREAICFYADQ LLNAPITADTIRHTTFFLFQLSARRANDYAMYFKDRHSHLSVLKTEQAKVFGICHSMS VNKDWKGISEKLMKLADLEDNFRLELLKVGY*" /label="yobF CDS" gene complement(1896088..1897011) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /label="yobF gene" promotor_-10 complement(1896867..1896886) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1896870) /Source="Nicolas_upshifts" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1896898..1896905) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1897022..1897041) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-10" upshifts complement(1897043) /Source="Nicolas_upshifts" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="upshifts" promotor_-35 complement(1897056..1897063) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-35" CDS complement(1897064..1897237) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="YP_003097737.1" /db_xref="EnsemblGenomes-Gn:BSU18898" /db_xref="EnsemblGenomes-Tr:CAX52632" /db_xref="UniProtKB/Swiss-Prot:C0H424" /translation="MTEIKANSTVMIHVLADETLSSIKREYVEVDRKTEIGEKIIIVD KNDPDDEYENGAI*" /label="yozW CDS" gene complement(1897064..1897237) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /label="yozW gene" CDS 1897382..1897606 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097738.1" /db_xref="EnsemblGenomes-Gn:BSU18899" /db_xref="EnsemblGenomes-Tr:CAX52633" /db_xref="UniProtKB/Swiss-Prot:C0H425" /translation="MNFLLDLFTNWTFDKVLDYTLAAVIWSVFKSRSKQNKYPGYFEK IRRYRNLHPLLRSLSMRVLLSITIHPYMFS*" /label="yozX CDS" gene 1897382..1897606 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /label="yozX gene" CDS complement(1897610..1898065) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389771.1" /db_xref="EnsemblGenomes-Gn:BSU18900" /db_xref="EnsemblGenomes-Tr:CAB13782" /db_xref="SubtiList:BG13757" /db_xref="UniProtKB/Swiss-Prot:O31839" /translation="MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQL MEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLV TVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR*" /label="yozJ CDS" gene complement(1897610..1898065) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /label="yozJ gene" promotor_-35 1898125..1898132 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1898147..1898166 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1898151 /Source="Nicolas_upshifts" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="upshifts" CDS 1898190..1898450 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="YP_003097739.1" /db_xref="EnsemblGenomes-Gn:BSU18908" /db_xref="EnsemblGenomes-Tr:CAX52634" /db_xref="UniProtKB/Swiss-Prot:C0H426" /translation="MNLRKILLSSALSLGMLVSAAPVLATSSSSEVIVKSDEYDYDTI YQLSPLPNFKPSIEYNGYTYTLTRYYFDYSIQFYTAIYTKVV*" /label="yozY CDS" gene 1898190..1898450 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /label="yozY gene" downshifts 1898397 /Source="Nicolas_upshifts" /id="D1033" /incds=0 /nref=1 /ntot=221 /MaxReadThrough="4.57606" /MaxDrop="3.58254" /score="4.613667" /energy="-8.7" /TU="U1530" /idTUdmin="U1530" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" promotor_-35 1898865..1898868 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1898882..1898901 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1898899 /Source="Nicolas_upshifts" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1899011 /Source="Nicolas_upshifts" /id="D1034" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="3.18248" /MaxDrop="3.66335" /score="32.4789235" /energy="-13.7" /TU="U1530,U1531" /idTUdmin="U1530" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS 1899228..1899368 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage holin (fragment)" /db_xref="PSEUDO:CAX52635.1" /translation="MTVFGDDLTEKFNALLTFLTALGIIVDPTTQGISDSEQAMDYDS PR*" /label="yozZ CDS" gene 1899228..1899368 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /pseudo /label="yozZ gene" downshifts 1899365 /Source="Nicolas_upshifts" /id="D1035" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.30104" /MaxDrop="4.04304" /score="32.4789235" /energy="-13.7" /TU="NA" /idTUdmin="U1531" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 1899450..1899457 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1899469..1899488 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1899470 /Source="Nicolas_upshifts" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="upshifts" CDS 1899523..1900638 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:16816200, 25225273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 25225273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389772.1" /db_xref="EnsemblGenomes-Gn:BSU18910" /db_xref="EnsemblGenomes-Tr:CAB13783" /db_xref="GOA:O34930" /db_xref="InterPro:IPR011990" /db_xref="SubtiList:BG12664" /db_xref="UniProtKB/Swiss-Prot:O34930" /translation="MSKIASEVVATTLNDWYIAIKKQKVDESIKYYSEIKKLFDEMEE DQEVLAYYSLLEERHKMLLHSSRGEPLQKHTYFTEDNQNFITKTNDKLEYNFYLFEAM YEAYNKNYDRAINLYGLAEKKLAEIPDEIEAAEFYSKVSYLYTLVKQSIVAQHYIKNA ISIYKRHPDYKCKLATSTMIAAANYADMKRFEEAEQYYLEAIDIAKETKDEFLKAQLF HNLSIVYSDWNKPDKCIESLEKAIGNESWLHSIYYINSLFMMIKELFKIDEKMKAINF YNKAQERLILMENKVYEAKISILYNLYCGELKNNFNNCISNIEFLKQQNELESVDELS YIAAKRFESIGAFEEATSFFNAKIWAEQKMNQVEGIL*" /label="rapK CDS" gene 1899523..1900638 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /label="rapK gene" promotor_-35 1900362..1900370 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1900379 /Source="Nicolas_upshifts" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1900382..1900400 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1900635..1900757 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587781, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587781, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapK" /protein_id="NP_389773.1" /db_xref="EnsemblGenomes-Gn:BSU18920" /db_xref="EnsemblGenomes-Tr:CAB13784" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG12646" /db_xref="UniProtKB/Swiss-Prot:O31840" /translation="MKKLVLCVSILAVILSGVALTQLSTDSPSNIQVAERPVGG*" /label="phrK CDS" gene 1900635..1900757 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /label="phrK gene" downshifts 1900751 /Source="Nicolas_upshifts" /id="D1036" /incds=0 /nref=232 /ntot=252 /MaxReadThrough="2.33184" /MaxDrop="6.45227" /score="9.89565332" /energy="-10.4" /TU="NA" /idTUdmin="U1532" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1900883..1901536) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative DNA phage repair protein; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18930" /db_xref="EnsemblGenomes-Tr:CAB13785" /db_xref="GOA:C0SPA8" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="PSEUDO:CAB13785.2" /db_xref="SubtiList:BG13500" /db_xref="UniProtKB/Swiss-Prot:C0SPA8" /translation="MAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIA RWRYEDVPNRLWKVRPLSKMWGIGGRMERNLNRMGISTVGQLAKFPLELLEKKFGIMG NQLYYHAHGIDLSEIGAPLMQGQISFGKSQILFRDYTKREEIKAVLLEICEEVARRAR TYNKVGRTISLGIGYSKDELGGGFHRSKTIDFPTNITMDIYKCCLMFFNKFYSGKKQ* " /label="yobHc CDS" gene complement(1900883..1901536) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /pseudo /label="yobHc gene" downshifts complement(1901157) /Source="Nicolas_upshifts" /id="D1037" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="1.36944" /MaxDrop="2.50062" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(1901573..1901920) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /function="16.9: Replicate" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12137951; Product type h: extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage DNA repair protein fragment; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18940" /db_xref="EnsemblGenomes-Tr:CAB13786" /db_xref="GOA:O31841" /db_xref="InterPro:IPR001126" /db_xref="PSEUDO:CAB13786.1" /db_xref="SubtiList:BG13758" /db_xref="UniProtKB/Swiss-Prot:O31841" /translation="MTDYSQFPRENILCVDMKSFYASVSAVAMGLNPLTCYLAVVGNT DRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIYIVNPQMKLFIRVSTEITKLFYR FVPEKCVHTYSID*" /label="yobHm CDS" gene complement(1901573..1901920) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /pseudo /label="yobHm gene" CDS complement(1901913..1902206) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /function="16.6: Maintain" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein of phage origin; putative defective prophage 6" /protein_id="NP_389776.1" /db_xref="EnsemblGenomes-Gn:BSU18950" /db_xref="EnsemblGenomes-Tr:CAB13787" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG13759" /db_xref="UniProtKB/Swiss-Prot:O31842" /translation="MMLEQLIQLKQDLIDGSKVEKPSLDDKQIDEMDILVSEALEFNK ELKFKLFNKGFVENVTGRVHYINFEQQKLHVKDQNDNTVYINMNNIIRVIYND*" /label="yozL CDS" gene complement(1901913..1902206) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /label="yozL gene" upshifts 1902357 /Source="Nicolas_upshifts" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1902358..1902377 /Source="Nicolas_upshift_promotors" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1902415..1902750 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative bacteriophage protein; putative defective prophage 6" /protein_id="NP_389777.1" /db_xref="EnsemblGenomes-Gn:BSU18960" /db_xref="EnsemblGenomes-Tr:CAB13788" /db_xref="SubtiList:BG13760" /db_xref="UniProtKB/Swiss-Prot:O31843" /translation="MKKRLIGFLVLVPALIMWGITLIESNKKTPVEVLESAWDEFGLF SFEIGITDPAITIGMDQTKSEAKLREYLKDNLSREAKEKYKIYIFKDDTDKLEKEHQE YLKENNLNK*" /label="yozM CDS" gene 1902415..1902750 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /label="yozM gene" promotor_no_box complement(1902789..1902889) /Source="Nicolas_upshift_promotors" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(1902796) /Source="Nicolas_upshifts" /id="D1038" /incds=0 /nref=148 /ntot=238 /MaxReadThrough="2.4012" /MaxDrop="4.9328" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1902797..1906402) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15128444; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage repair NTPase with transmembrane helices; putative defective prophage 6" /protein_id="NP_389778.1" /db_xref="EnsemblGenomes-Gn:BSU18970" /db_xref="EnsemblGenomes-Tr:CAB13789" /db_xref="GOA:O34784" /db_xref="InterPro:IPR011646" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13501" /db_xref="UniProtKB/Swiss-Prot:O34784" /translation="MGEIKKKFVQWLEKLLIRLKEPNVKEESLFEDLSPSNDVDTDGK YSKALSWGLENKKVKNIALTGPYGSGKSSILNTFQKQYSREYSFLNISLATFNTDTDD MENKLEKSILQQMIYRVHDRTIPFSRFKRIKHIRTKSIIINLIFFFAFIIVGIYLFKP DALKGIYAETLVSRSLGTEDQQQIRLTILLALFFIVYPLLAYKRIYHFVRANLKLNKV TIANTTLEKNTGEENSSIFDKYLDEILYFFEASKYNVVIFEDLDRFNNIGIFERLREL NELINNSEQIDRRVVFIYAIKDDIFGDADTEKLTRDRTKFFDFIIPVIPIINASNSGD ILKKKIKHSPYSDLINTHFLEDVTIYIDDMRVLKNIFNEFVIYQQKLSAIDLDPNKML AMIIYKNIYPVDFSKLQYNKGLVYEIFQKKQLIIEEQIKLINAKIQQLERKLANIEVE SLKSIAELNFIYLSELEISNLNSNYDINIDGEVFRGNTSNKDRFFEKLKNADTIYCYL RNRNGPATIKEIATVFGRKPNYFEREDAIKAIEKNEIQKFKKELLELEREKQEIRAQS LQVLITKMNSKDVFSDKLYEKKLLVYLLRHGYIDEMYNHYITYFYPESLSLSDIKFVF SIKNHESLPYSFELDNIGKIMSKLVGAEFKQIEVLNFHLLNYIMDHSEYRNYYDSIIE RLANGSKESVTFIDGFKERAINKAAFIQSISSKWDDFWSFIELRSNYTQQKKEEYLSD ILTYADIADIIRMNKESVMSFTLSKYLNLLSLVSDEEKIKELLLKLQVKFKSLDHLLN SETIYDFVVQRNLYEINIKTLSVILNDAPNITYAAVKNSDQQAVINYVNDNIDIFVEK VLLTEEIEEPEESFLELLNREDLDKRVKHAMIMKKTFAISDIGELIKELWPIVIRENK MVACWSNVITSYVEYNKKMPDFLIAFLNNPVNRKELSKNNIEAFDDKFDEAILEDISE EIINSRDITDETFEVLIASIQSWIYFPLGNVSEKRAKLLIDNDLLSLTPENFKELKLN FDTLHIQLALRNPDEFIDKQGDFSLDANDIKQLIDSNELSQFNKEIFVQHLNSNCLTD GNNDILKDTIYFINEHNLKITNELLTFLLESPTTLDTRLSLLAGQIKHIDNESITEFL TKIGEPYSEIAEKGRRIKISNNRTNKALVTALESKNYISSFKEDRERLRVNTKKK*" /label="yobI CDS" gene complement(1902797..1906402) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /label="yobI gene" upshifts complement(1902829) /Source="Nicolas_upshifts" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1906403..1906547) /Source="Nicolas_S_feature" /locus_tag="new_2069030_2069174_c" /HighExp="LBGstat, Lbstat, M0t90, T3.0H, T1.30H, T3.30H, MG 150, T2.30H, T4.0H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.936" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S713" misc_feature complement(1906540..1906559) /Source="Nicolas_upshift_promotors" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1906547) /Source="Nicolas_upshifts" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1906549..1906634) /Source="Nicolas_S_feature" /locus_tag="new_2069176_2069261_c" /HighExp="LBGstat, C30, Lbstat, M0t90, GM 120, GM 25, GM 150, nit, GM 90, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S714" CDS complement(1906635..1906934) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative fragment of phage protein; putative defective prophage 6" /db_xref="PSEUDO:CAX52636.1" /translation="MATEGYGGNNSAPSRSIGFSEFCETLEKNEVVKPENKKSSLDLN NSLDYWKSRFNPGGNLSALDSQVLDIIKKAYNLGMVNKDNMLLRNEAINAYKNSI*" /label="yoyA CDS" gene complement(1906635..1906934) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /pseudo /label="yoyA gene" S_feature complement(1906935..1907072) /Source="Nicolas_S_feature" /locus_tag="new_2069562_2069699_c" /HighExp="LBGstat, C30, MG 150, GM 150, M0t90, Lbstat, GM 25, GM 90, GM 120, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S715" promotor_-10 complement(1907050..1907068) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1907072) /Source="Nicolas_upshifts" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1907082..1907088) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(1907105..1907488) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /product="small regulatory antitoxin RNA, toxin-antitoxin type I system (BsrE/AsrE)" /experiment="publication(s) with functional evidences, PMID:18948176, 23059907, 24576839, 26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23059907, 24576839, 26565032, 26940229; Product type n: RNA" /label="asrE RNA" gene complement(1907105..1907488) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /label="asrE gene" S_feature complement(1907119..1907355) /Source="Nicolas_S_feature" /locus_tag="new_2069746_2069982_c" /HighExp="Salt, Etha, S4, LoTm, dia5, Diami, S5, MG 120, S3, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S716" promotor_-35 1907152..1907154 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1907162) /Source="Nicolas_upshifts" /id="D1039" /incds=0 /nref=39 /ntot=216 /MaxReadThrough="3.37292" /MaxDrop="5.0558" /score="17.2005818" /energy="-10" /TU="U1541" /idTUdmin="U1539" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 1907170..1907189 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1907175 /Source="Nicolas_upshifts" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="upshifts" S_feature 1907197..1907350 /Source="Nicolas_S_feature" /locus_tag="new_2069824_2069977" /HighExp="T1.30H, B60, T2.0H, M9-stat, BT, T0.30H, B36, T1.0H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87861900000000004" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S717" CDS 1907256..1907348 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /experiment="publication(s) with functional evidences, PMID:26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26565032, 26940229; Product type f: factor" /codon_start=1 /transl_table=11 /product="type I toxin (BsrE/AsrE)" /protein_id="YP_009513965.1" /translation="MSTFQALMLMLAIGSFIIALLTYIEKIDLP*" /label="bsrE CDS" gene 1907256..1907348 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /label="bsrE gene" downshifts 1907307 /Source="Nicolas_upshifts" /id="D1040" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="6.71009" /MaxDrop="3.13767" /score="33.1812693" /energy="-14.4" /TU="U1538" /idTUdmin="U1538" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1907357..1907491) /Source="Nicolas_S_feature" /locus_tag="new_2069984_2070118_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, S4, M9-stat, T-1.10H, S7, B60, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S718" downshifts 1907373 /Source="Nicolas_upshifts" /id="D1041" /incds=0 /nref=135 /ntot=196 /MaxReadThrough="2.41468" /MaxDrop="5.72925" /score="33.1812693" /energy="-14.4" /TU="NA" /idTUdmin="U1538" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1907400) /Source="Nicolas_upshifts" /id="D1042" /incds=0 /nref=13 /ntot=114 /MaxReadThrough="6.34283" /MaxDrop="4.1536" /score="3.24083135" /energy="-14.3" /TU="U1539,U1541" /idTUdmin="U1539" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" upshifts complement(1907491) /Source="Nicolas_upshifts" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1907493..1907616) /Source="Nicolas_S_feature" /locus_tag="new_2070120_2070243_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, T-1.10H, T1.0H, T-1.40H, Etha, SMMPr, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S719" misc_feature complement(1907500..1907501) /Source="Nicolas_upshift_promotors" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(1907617..1908459) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11866510" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; putative defective prophage 6" /protein_id="NP_389779.1" /db_xref="EnsemblGenomes-Gn:BSU18980" /db_xref="EnsemblGenomes-Tr:CAB13790" /db_xref="GOA:O34774" /db_xref="SubtiList:BG13502" /db_xref="UniProtKB/Swiss-Prot:O34774" /translation="MELLDIWNWIQQNGILTAVITGIVALLFNQRQKSIERFYSQSGE TLEKILEPMYYSLKEIKNEEDENHKMVLIEKFFEEYSGKKGKLSKLRNILLIDQILNT EDCFREYILNKNSENRKKLFYKMRMLDQAVNKEYRSIFVTLNKNYNWYKVLFRTNYIL SAVFVFVRWFKETLAFFVGASAFAFIPLLYDKYLGEQVLGNWLEVNKLIFGLSCSALY IFWIIHYFLLKDTMQRKDEISLFQEWFDKTKLGKWTNKNVWGKIGNWNVERRARRVRN DEDV*" /label="yobJ CDS" gene complement(1907617..1908459) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /label="yobJ gene" promotor_-35 1907954..1907957 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1907967 /Source="Nicolas_upshifts" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1907973..1907977 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1908485..1908500) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-10" upshifts complement(1908486) /Source="Nicolas_upshifts" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="upshifts" S_feature complement(1908488..1908570) /Source="Nicolas_S_feature" /locus_tag="new_2071115_2071197_c" /HighExp="MG 150, T-3.40H, Cold, SMM, Lbstat, SMMPr, ferm, T-2.40H, Fru, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S720" promotor_-35 complement(1908512..1908521) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-35" S_feature complement(1908572..1908658) /Source="Nicolas_S_feature" /locus_tag="new_2071199_2071285_c" /HighExp="Lbstat, M0t90, HiOs, HiTm, M40t90, dia15, S2, S1, T-0.40H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S721" downshifts complement(1908615) /Source="Nicolas_upshifts" /id="D1043" /incds=0 /nref=5 /ntot=191 /MaxReadThrough="4.07519" /MaxDrop="4.09712" /score="-3.79237769" /energy="-8.4" /TU="U1542" /idTUdmin="U1542" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(1908659..1909117) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /function="17.2: Prophage functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin inhibiting Rnase RttL" /protein_id="NP_389780.1" /db_xref="EnsemblGenomes-Gn:BSU18990" /db_xref="EnsemblGenomes-Tr:CAB13791" /db_xref="InterPro:IPR018958" /db_xref="PDB:2PRV" /db_xref="SubtiList:BG13503" /db_xref="UniProtKB/Swiss-Prot:O34596" /translation="MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYK WFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEHYGLTDGLVVIEDVDYFAYCLDT NKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD*" /label="rttM CDS" gene complement(1908659..1909117) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /label="rttM gene" CDS complement(1909127..1910929) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phage toxin ribonuclease; putative defective prophage 6" /protein_id="NP_389781.1" /db_xref="EnsemblGenomes-Gn:BSU19000" /db_xref="EnsemblGenomes-Tr:CAB13792" /db_xref="GOA:O34330" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR026834" /db_xref="SubtiList:BG13504" /db_xref="UniProtKB/Swiss-Prot:O34330" /translation="MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSE FSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSSMSATLEDAKMSDAYIEESFLEH ELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKK GDIEKHSEAYLSVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQ LAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFITDPGETLSALGNAA MHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKAD AAGKVINKASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAK KIPDGTRKPFTGQKKSPPWLNKEKYDAYEIEGKVKAKGKVKDVSRRVYTMKDIDINQK TEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDVIHQLKS DGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN*" /label="rttL CDS" gene complement(1909127..1910929) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /label="rttL gene" promotor_-10 complement(1910953..1910972) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-10" upshifts complement(1910969) /Source="Nicolas_upshifts" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="upshifts" promotor_-35 complement(1910984..1910991) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-35" CDS complement(1911031..1911588) /gene="yobM" /locus_tag="Delta6_BSU_19010_SNPvariant" /old_locus_tag="BSU_19010" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="NP_389782.3" /db_xref="EnsemblGenomes-Gn:BSU19010" /db_xref="EnsemblGenomes-Tr:CAB13793" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG13505" /db_xref="UniProtKB/Swiss-Prot:O34377" /modified_by="User" /translation="MTNFVHKTVNGLKSLLDEKGAIQLFCSEGDIMEFLVTFSQDKAT LNDIQSFEAKHQLTLPQDYQKFMTLHNGAKIFEILSDGENIGGGLQLFSLEEIEEELK YEDLFEDINGIPIGYLLEECHLMIDKDKVNQGDPNYLYIFESGLEYNPLNLNFEKFLD RYILANGEPFWDWRYYTAENYYRTR*" /label="Delta6_BSU_19010_SNPvariant" gene complement(1911031..1911588) /gene="yobM" /locus_tag="Delta6_BSU_19010_SNPvariant" /old_locus_tag="BSU_19010" /modified_by="User" /label="Delta6_BSU_19010_SNPvariant" Polymorphism join(1911521,1911523) /Source="geneious" /ID="SNP_BsDelta6_2074149_2074149" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="K -> Q" /CDS_Position=67 /Change="T -> G" /Codon_Change="AAA -> CAA" /Coverage=154 /locus_tag="BSU_19010" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="Delta6_BSU_19010_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(1911595..1911990) /Source="Nicolas_S_feature" /locus_tag="new_2074222_2074617_c" /HighExp="M0t90, LoTm, M40t90, Lbstat, LBGstat, M9-stat, T0.30H, T2.30H, T1.0H, T2.0H" /AntisenseName="yobN" /AntisenseCor="-6.3634699133798794E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S722" promotor_-35 1911653..1911658 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-35" promotor_-10 1911674..1911692 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-10" upshifts 1911683 /Source="Nicolas_upshifts" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="upshifts" S_feature 1911685..1911811 /Source="Nicolas_S_feature" /locus_tag="new_2074312_2074438" /HighExp="S3, S4, S5, S6, M9-stat, S8, S7, T5.0H, T4.0H, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S723" CDS 1911716..1913152 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /EC_number="1.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amine oxidase (flavoprotein)" /protein_id="NP_389783.2" /db_xref="EnsemblGenomes-Gn:BSU19020" /db_xref="EnsemblGenomes-Tr:CAB13794" /db_xref="GOA:O34363" /db_xref="InterPro:IPR001613" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13506" /db_xref="UniProtKB/Swiss-Prot:O34363" /translation="MNSLMNDDMVKIIRNGLSASQHPKHILVIGAGLSGLVSASLLKN AGHRVTILEASGRAGGRVCTLRSPFSDDLYFNAGPMRIPNNHSLTLEYIKKFKLPTNV FINRTPMDIIYANGIKTRLQVFERAPGILRYPVAPNEQGKTSEELMLSLLQPILNFIN QNPARNWRIVEEQYKNHSLSSFLNTYFSYGAIDMIGVLLDMEAYMGMSLVEVLRESIF FSSPAHFYEITGGMDLLPHAFLPQLKTNILYHQKMMKMSQGENRVTIHCQHQQTAEFT SFTADLAIVTIPFSTLRFVKVEPYHSFSYYKRRAIRELNYISATKIGIEFKSRFWEKA GQHGGKSITDLPIRFSYYPSRNIGANGHAVILASYTWADEALIWDSLSEGERIQYTLL NLSEIYGDIVWSEFVSGTSFSWSQYPYSAGGFTAFEPGQELELYPYIPVPEGRVHFAG EHASLTHAWMQGAIESGIRVAYEVNRLP*" /label="yobN CDS" gene 1911716..1913152 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /label="yobN gene" promotor_-10 complement(1911976..1911995) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911990) /Source="Nicolas_upshifts" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1912009..1912015) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1913153..1913484 /Source="Nicolas_S_feature" /locus_tag="new_2075780_2076111" /HighExp="S3, S8, S4, S5, S7, M9-stat, S6, T5.0H, C30, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S724" promotor_-35 1913466..1913474 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1913485..1913503 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1913486..1913578 /Source="Nicolas_S_feature" /locus_tag="new_2076113_2076205" /HighExp="M9-stat, T1.30H, T2.0H, S2, T2.30H, Lbstat, BC, T0.30H, T3.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S725" upshifts 1913486 /Source="Nicolas_upshifts" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="upshifts" CDS 1913579..1915999 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11562162, 19450535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage-related pre-neck appendage protein; defective prophage 6" /protein_id="NP_389784.1" /db_xref="EnsemblGenomes-Gn:BSU19030" /db_xref="EnsemblGenomes-Tr:CAB13795" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR021865" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG13507" /db_xref="UniProtKB/Swiss-Prot:O34433" /translation="MVHFKNCPDPSLNANSQSHPEFSSELEHIKTRMQNFIKHSVTDQ NIEVTDARVTAEGEVTSLLKERLDKEYYRLLSKITREVNVADFGAVPDGRDNTEAFRK AIGNGRVKVHVPAGEYLVQGIKLPSWTTIVGQGKGITVIKLHEDTPAHEWVITNDDYQ NGNRNIFVQGMSLDWNPSRQCGVRNPGGQFSSCLTFAKVEYGWIKDVEAINAGLHGID ITSPTYDHLPDTDWTKDGSRYIWIDNCVTYGSGDDGITTHYSEYIFISNCHSGNPRGT EFAEGVSNSNGIEIDDGSRHVWLLNNFTSGNIRGVEVKAHELWPASQNVHIIGHISYR DVRAFDLRHIGHHQITDPESTTAYDVTLIDCSAVEPVFNSLYDAVTPRALVISAYKNV NVSGFTAIGDPDYDYKENPVVALQYRSQNITINGIKIRGFKKAGVDINLSGGSNKTDY IKISNFDIYKSAPKGISIGGGLYNVNILNGTMITDNGTVAIQSPNNQATILGVQSEGY SVAASIKGQTYQQVPINLKGGIQLATTSGFAVNQTSAVIAGTGDITARGERNAVISSS GGSSTEGSRALIASSNNAHIRGNQASRTILSSENIILEEPYTVAGGHQSIKWLLDSVR GNGTFAGAISSSLGGYGEYFESSTGQLIHTGTIVTLRGEKIVPANVGDYMLGVISETS AFISGASSFVWQGRYLTNEFGGFIYETVTDEESGELIRVPKQNPDYDTALEANYHSRA ARDEWHVVGLVGQHYVRIDETVNQGDYLTAHNGIGTKATEGSWKVMKITSAYTSEKGY GIALTVIK*" /label="yobO CDS" gene 1913579..1915999 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /label="yobO gene" S_feature complement(1915921..1916556) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" S_feature 1916000..1916457 /Source="Nicolas_S_feature" /locus_tag="new_2078627_2079084" /HighExp="M9-stat, Lbstat, BC, T1.30H, S2, T0.30H, T2.0H, T3.0H, T2.30H, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S727" promotor_-35 1916432..1916439 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1916451..1916470 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1916459..1916569 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" upshifts 1916459 /Source="Nicolas_upshifts" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1916469..1916576 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" gene 1916469..1916576 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /label="bsrF gene" downshifts 1916554 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1916587..1916919) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1916587..1916919) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1916601) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1916984..1917709) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1916984..1917709) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1917724..1918467) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1917724..1918467) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1918495..1918514) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1918514) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1918528..1918534) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1918545..1919120) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1918545..1919120) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1919126..1919827) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1919126..1919827) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1919857..1919876) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1919857) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1919861..1919876) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1919891..1919898) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1919891..1919898) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1919901) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1919904..1920386) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1919904..1920386) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1920425..1920442) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1920429) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1920440..1921381) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1920440..1921381) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1920473) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1921411..1921430) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1921419) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1921444..1921448) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1921452..1921461 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1921474..1921493 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1921482 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1921497..1921561 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1921533..1921538 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1921554..1921572 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1921563 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1921587..1922132 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1921587..1922132 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1922091 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1922159..1922482) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1922159..1922482) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1922166) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1922503..1922522) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922514) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1922535..1922542) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1922603..1922609 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1922620 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1922624..1922643 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1922676..1923353 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1922676..1923353 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1923345 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1923443..1923979) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1923443..1923979) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1923466) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1924006..1924025) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924026) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924039..1924046) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1924116..1924898) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1924116..1924898) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1924125) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1924920..1924938) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924939) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924952..1924958) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1924995..1925002 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1925017..1925036 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1925021 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1925069..1925566 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1925069..1925566 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1925573..1925576 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1925592..1925611 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1925594 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1925630..1926607 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1925630..1926607 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1926579 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1926704..1926711 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1926726..1926745 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1926733 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1926769..1927827 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1926769..1927827 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1927828..1927897 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1927881..1927887 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1927899..1927918 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1927899 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1927947..1929059 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1927947..1929059 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1929078..1929677 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1929078..1929677 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1929615 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1929659 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1929699..1930197) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1929735) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1930169..1930178 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1930181..1930199) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1930190..1930384 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1930190 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1930191..1930210 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930197) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1930216..1930221) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1930272..1931135) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1930272..1931135) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1930285) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1930341 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1930373) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1930386..1931153 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1931131..1931135 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1931144..1931158 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1931155 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1931174..1931193) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931187) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1931189..1931382) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1931205..1931211) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1931383..1933158) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1931383..1933158) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1933159..1933289) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1933282..1933484) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1933282..1933484) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1933334) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1933482..1933501) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1933500) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1933502..1933694) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1933514..1933521) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1933723..1934349) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1933723..1934349) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1933739) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1934383..1934402) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1934396) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1934416..1934423) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1934500..1934991) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1934500..1934991) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1934509) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1935003..1935021) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1935015) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1935035..1935041) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1935066..1935398) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1935066..1935398) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1935399..1935689) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1935414..1935419 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1935434..1935452 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1935436 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1935476..1935703 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1935476..1935703 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1935690..1936166) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1935690..1936166) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1935704..1936211 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1936167..1936269) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1936184..1936189 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1936204..1936222 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1936213 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1936233..1936496 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1936233..1936496 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1936249..1936268) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1936269) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1936271..1936796) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1936282..1936286) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1936501..1936734 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1936501..1936734 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1936721 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1936820..1937164) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1936820..1937164) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1936841) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1937165..1937237) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1937233..1937252) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1937237) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1937239..1937342) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1937266..1937271) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1937329..1937344) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1937342) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1937357..1937366) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1937485) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1937521..1937724) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1937521..1937724) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1937745..1937764) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1937763) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1937765..1937831) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1937780..1937787) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1937797..1937804 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1937816 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1937818..1937830) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1937818..1937837 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1937821..1937953 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1937842) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1937954..1939441 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1937954..1939441 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1938397..1938414) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938403) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1938427..1938435) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1939427 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1939489..1939494 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1939510..1939528 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1939515 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1939542..1941440 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1939542..1941440 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1940485..1940504) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940493) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940518..1940527) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1941430..1942275 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1941430..1942275 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1942276..1943782 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1942308..1943645) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1942308..1943645) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1942319) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1943673..1943692) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1943688) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1943690..1944848) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1943707..1943714) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1943766..1943769 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1943784..1943803 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1943784 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1943864..1944829 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1943864..1944829 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1944817 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1944879..1946132) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1944879..1946132) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1944893) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1946148..1948982) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1946148..1948982) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1949077..1949096) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949092) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1949094..1949210) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1949111..1949118) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949211..1951127) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1949211..1951127) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1951138..1952052) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1951138..1952052) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1952056..1952075) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1952071) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1952092..1952096) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1952116..1952706) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1952116..1952706) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1952799..1954043) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1952799..1954043) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1952801) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1954106..1954124) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1954119) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1954121..1954341) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1954137..1954144) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1954327..1954345) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1954341) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1954357..1954365) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1954425..1955642) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1954425..1955642) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1954451) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1955675..1955694) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955683) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1955708..1955715) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1955878..1956501) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1955878..1956501) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1956502..1956652) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1956528..1956534 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1956540 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1956548..1956559 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1956566..1956574 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1956582..1956682 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1956586..1956604 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1956597 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1956635..1956653) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1956642..1956727 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1956642 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1956652) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1956669..1956675) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1956703..1956710 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1956723..1956742 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1956729 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1956767..1958125 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1956767..1958125 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1957109..1957120) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957114) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1957134..1957140) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1958141..1958989 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1958141..1958989 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1958405..1958424) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958412) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958438..1958446) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1958952 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1958984) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1959015..1959680) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1959015..1959680) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1959029) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1959699..1960049) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1959699..1960049) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1960046..1960324) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1960046..1960324) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1960351..1960370) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960367) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1960385..1960391) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1960400..1961296) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1960400..1961296) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1961138..1961147 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1961158 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1961161..1961180 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1961176..1961394 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1961320..1961339) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961340) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961351..1961358) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1961395..1961868 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1961395..1961868 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1961865 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1961903..1962139) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1961903..1962139) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1961911) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1962162..1962181) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1962177) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1962195..1962204) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1962224..1963558) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1962224..1963558) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1963559..1963694) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1963691..1963710) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963701) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963725..1963732) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1963790..1963797 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1963812..1963831 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1963815 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1963816..1963922 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1963923..1964312 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1963923..1964312 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1964322 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1964719..1965057) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1964719..1965057) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1965080..1965087 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1965101..1965120 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1965110 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1965114..1965186 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1965145..1965164) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965148) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965176..1965182) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1965187..1965795 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1965187..1965795 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1965785 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1965838..1966440) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1965838..1966440) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1966456..1967367) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1966456..1967367) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1967396..1967415) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1967412) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1967431..1967436) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1967488..1967491 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1967506..1967525 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1967508 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1967551..1967751 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1967551..1967751 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1967751..1969241 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1967751..1969241 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1968486..1968497) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1968490) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1968511..1968517) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1969229 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1969276..1970676) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1969276..1970676) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1969300) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1970447..1970456 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1970468..1970483 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1970482 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1970696..1970715) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1970716) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1970729..1970736) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1970775..1970784 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1970790 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1970797..1970816 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1970829..1971530 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1970829..1971530 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1971555..1971563 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1971577..1971596 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1971582 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1971618..1971869 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1971618..1971869 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1971890 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1971940..1972761) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1971940..1972761) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1971966) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1972762..1972843) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1972844..1973545) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1972844..1973545) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1973546..1973635) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1973620..1973639) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1973635) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1973655..1973659) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1973693..1973699 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1973714..1973725 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1973731 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1973747..1973872 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1973747..1973872 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1973870 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1973912..1974226) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1973912..1974226) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1973924) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1974247..1974265) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1974254) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1974276..1974284) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1974287..1974898) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1974287..1974898) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1974976..1975152) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1974976..1975152) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1974980) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1974991) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1974995..1975014) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1975030..1975033) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1975166..1975184) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1975187) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1975189..1975410) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1975200..1975205) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1975210..1975215 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1975230..1975248 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1975232 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1975271..1975414 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1975271..1975414 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1975411..1976091) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1975411..1976091) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1975415..1976426 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1976118..1976137) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1976124) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1976151..1976160) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1976242..1976466) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1976242..1976466) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1976256) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1976507..1976526) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1976519) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1976553..1976831) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1976553..1976831) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1976828..1978243) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1976828..1978243) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1977499..1977502 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1977518..1977537 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1977523 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1978272..1979099) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1978272..1979099) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1979077..1980387) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1979077..1980387) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1980396..1981049) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1980396..1981049) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1981034..1981723) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1981034..1981723) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1981730..1983064) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1981730..1983064) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1983045..1983200) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1983045..1983200) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1983083..1983101) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983099) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1983117..1983122) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1983194..1983427) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1983194..1983427) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1983201) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1983303..1983307 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1983316..1983330 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1983331 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1983332..1983351) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983341) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1983366..1983375) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1983387..1984166) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1983387..1984166) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1984195..1985475) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1984195..1985475) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1984843..1984861) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1984859) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1984875..1984882) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1985443..1985461) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1985453) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1985477..1985482) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1985540..1985845) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1985540..1985845) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1985673) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1985869..1985888) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1985884) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1985902..1985911) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1985981..1985990 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1986004..1986023 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1986004 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1986025) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1986027..1986041) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1986050..1986054) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1986050..1986451 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1986050..1986451 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1986458..1987411 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1986458..1987411 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1987401 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1987482..1988630) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1987482..1988630) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1987499) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1988643..1988647 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1988656..1988675) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1988663..1988682 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988665) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1988673 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1988934..1988942 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1988956..1988975 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1988959 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1989000..1990025 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1989000..1990025 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1989403 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1989405..1989409 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1989419..1989420 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1990017 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1990069..1990500) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1990069..1990500) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1990074) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1990501..1991034) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1990501..1991034) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1991038..1991044 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1991055..1991165 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1991055 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1991057..1991076 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1991062..1991081) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1991082) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1991097..1991098) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1991166..1991591 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1991166..1991591 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1991579 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1991624..1992855 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1991641..1992978) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1991641..1992978) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1993050..1993244) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1993050..1993244) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1993063) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1993257..1993820) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1993257..1993820) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1993830..1994597) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1993830..1994597) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1994621..1994640) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1994638) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1994651..1994658) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1994675..1995256) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1994675..1995256) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1995257..1995372) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1995404..1995655) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1995404..1995655) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1995417) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1995678..1995697) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1995692) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1995741..1997009) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1995741..1997009) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1997043..1997062) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1997062) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1997074..1997081) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1997216..1997235 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1997219 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1997258..1998253 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1997258..1998253 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1998274..1998915 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1998274..1998915 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1998916..2000017 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1998954..1999574) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1998954..1999574) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1998980) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1999575..2000081) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1999575..2000081) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(2000078..2000872) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(2000078..2000872) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(2000956..2001489) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(2000956..2001489) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(2000961) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 2001419..2001424 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2001435..2002381 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 2001437 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2001441..2001459 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2001507..2002118) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(2001507..2002118) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(2002150..2002169) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2002169) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2002182..2002187) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2002338 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(2002378..2003151) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(2002378..2003151) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(2002413) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2003193..2003627) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(2003193..2003627) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(2003205) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2003656..2003675) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(2003667) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(2003669..2003733) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(2003689..2003696) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(2003712) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2003734..2005410) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(2003734..2005410) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(2005411..2005601) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(2005590..2005609) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2005601) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2005624..2005627) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2005699..2006832) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(2005699..2006832) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(2005715) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(2006854..2006873) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2006857) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2006892..2007509) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(2006892..2007509) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(2007525..2008007) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(2007525..2008007) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(2008008..2008155) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(2008146..2008164) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(2008156) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(2008175..2008183) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 2008209..2008218 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2008231..2008246 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 2008233..2008319 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 2008233 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 2008282..2008289 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2008304..2008323 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 2008321 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 2008350..2009255 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 2008350..2009255 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 2009290..2009309 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2009304 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 2009305..2009485 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 2009486..2010634 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 2009486..2010634 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(2009655..2010684) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 2010630 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2010666..2010685) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2010684) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2010700..2010708) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2010715..2010861 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 2010715..2010861 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 2010754..2010761 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2010775..2010794 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2010786..2010876 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 2010786 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 2010877..2011077 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 2010877..2011077 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 2011092 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(2011129..2011311) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(2011129..2011311) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 2011137..2011442 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(2011146) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2011372..2011390) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2011404..2011410) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2011408) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2011418..2011424 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2011439..2011450 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2011444 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 2011467..2011736 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 2011467..2011736 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 2011591 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 2011719 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(2011764..2011946) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(2011764..2011946) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(2011784) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2011939..2012619) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(2011939..2012619) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(2012620..2012757) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 2012636..2012641 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2012654..2012673 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2012659 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 2012702..2013391 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 2012702..2013391 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(2012755..2012771) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2012758) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2012759..2013148) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(2013129..2013148) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2013146) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2013160..2013168) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2013391..2013789 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 2013391..2013789 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 2013782..2013788 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2013803..2013814 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2013814 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 2013831..2013959 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 2013831..2013959 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 2013960..2014940 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(2013967..2014857) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(2013967..2014857) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(2014004) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2014879..2014898) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2014886) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2014910..2014916) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2014914 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2014958..2015104) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(2014958..2015104) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(2014974) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2015128) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2015129..2015140) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2015155..2015161) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2015179..2015436) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(2015179..2015436) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(2015456..2015475) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2015471) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2015487..2015494) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2015501..2019082) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(2015501..2019082) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(2019083..2019154) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(2019144..2019163) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2019154) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(2019199..2019396) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(2019242) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2019258..2019347) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(2019258..2019347) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(2019375..2019394) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2019396) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2019409..2019416) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2019418..2019924) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(2019418..2019924) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(2019928..2021025) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(2019928..2021025) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(2021043..2021054) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021046) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2021069..2021075) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2021099..2022415) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(2021099..2022415) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(2021112) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2022412..2022996) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(2022412..2022996) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(2023085..2023185) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(2023085..2023185) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(2023092) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(2023186..2023326) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(2023327..2024832) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(2023327..2024832) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(2024768..2024868) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2024808) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 2024820 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2024858..2024877) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2024874) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2024891..2024898) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2024944..2025936) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(2024944..2025936) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(2024962) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2025981..2026571) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(2025981..2026571) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(2026573..2027547) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(2026573..2027547) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(2027585..2028604) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(2027585..2028604) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(2028652..2028671) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2028662) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2028683..2028690) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2028725..2028732 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2028746..2028825 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 2028746 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2028747..2028766 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2028826..2029653 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 2028826..2029653 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 2029655..2030419 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 2029655..2030419 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 2030408 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2030450) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2030460..2032385) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(2030460..2032385) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(2032416..2032435) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2032420) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2032422..2032486) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(2032450..2032454) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2032487..2032678) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(2032487..2032678) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(2032697..2032715) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2032706) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2032708..2033013) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(2032731..2032736) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2032745..2032751 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2032766..2032777 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2032775 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 2032842..2032994 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 2032842..2032994 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 2033004 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2033047..2034204) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(2033047..2034204) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(2033058) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2034292..2034692) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(2034292..2034692) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(2034302) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2034689..2034708) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034707) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2034723..2034729) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2034751..2035047) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(2034751..2035047) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(2035072..2035091) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2035082) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2035105..2035112) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2035125..2035754) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(2035125..2035754) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(2035720) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2035756..2035983) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(2035756..2035983) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(2036011..2036030) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2036026) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(2036028..2036182) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2036044..2036052) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2036067..2036195) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(2036067..2036195) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(2036182) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(2036184..2036295) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2036185..2036204) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2036220..2036224) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2036296..2037537) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(2036296..2037537) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(2037251..2037269) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2037260) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(2037284..2037291) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2037553..2039802) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(2037553..2039802) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(2039818..2039837) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2039834) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2039851..2039857) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2039905..2040411) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(2039905..2040411) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(2039928) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2040455..2040474) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2040472) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2040488..2040495) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2040493..2040502 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2040516..2040535 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2040528 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 2040549..2040968 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 2040549..2040968 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 2040969..2041119 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2040989..2041366) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(2040989..2041366) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(2041022) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 2041364..2041509 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2041396..2041414) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041415) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2041428..2041437) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2041510..2041529 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2041511 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 2041554..2041742 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 2041554..2041742 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 2041758 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(2041781..2042152) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(2041781..2042152) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(2041814) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2042164..2042183) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042177) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042196..2042201) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2042198..2042443) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(2042198..2042443) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(2042469..2042487) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042474) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042499..2042507) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2042593..2042599 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2042614..2042625 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2042621 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 2042642..2042746 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 2042642..2042746 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 2042728 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2042771..2043733) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(2042771..2043733) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 2042901..2042910 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2042922..2042937 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2042922 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2042926..2043261 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2043232..2043236 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2043252..2043271 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2043263..2043773 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2043263 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2043734..2044190) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2043774..2044394 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 2043774..2044394 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(2044179..2044190) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2044190) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2044205..2044211) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2044416..2047160 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 2044416..2047160 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(2046830) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 2047146 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2047236..2047730) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(2047236..2047730) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(2047249) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2047727..2048386) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(2047727..2048386) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(2048405..2049103) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(2048405..2049103) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(2049104..2049195) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2049196..2050488) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(2049196..2050488) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(2050489..2050550) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2050550..2050569) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2050550) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2050584..2050591) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2050632..2051813) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(2050632..2051813) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(2050636) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2051836..2052321) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(2051836..2052321) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(2052269..2052288) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2052286) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2052301..2052308) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2052330..2052500) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(2052330..2052500) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(2052501..2052572) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2052534..2052540 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2052555..2052574) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2052555..2052566 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2052562..2052636 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2052562 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2052572) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2052574..2052642) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2052590..2052596) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2052606 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2052643..2055438) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(2052643..2055438) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 2053111..2053115 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2053112 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2053117..2053121 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2053768..2053783) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2053782) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(2053796..2053805) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2055439..2055563) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2055564..2055947) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(2055564..2055947) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(2055949..2056809) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(2055949..2056809) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(2056811..2057644) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(2056811..2057644) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(2057645..2057852) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2057847..2057866) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2057852) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2057883..2057887) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2057890..2058867) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(2057890..2058867) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(2058852..2060045) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(2058852..2060045) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(2060050..2061183) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(2060050..2061183) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(2061180..2061890) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(2061180..2061890) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(2061883..2062296) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(2061883..2062296) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(2062312..2063115) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(2062312..2063115) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(2063127..2063462) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(2063127..2063462) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(2063482..2063501) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2063492) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(2063515..2063522) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2063531..2063538 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2063547..2063566) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2063552..2063571 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2063558 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2063566) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 2063602..2064474 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 2063602..2064474 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(2064516..2065310) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(2064516..2065310) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(2064541) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(2065311..2065378) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2065379..2065936) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(2065379..2065936) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(2065937..2066016) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2066061) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2066083..2066850) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(2066083..2066850) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(2066885..2067559) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(2066885..2067559) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(2067561..2068064) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(2067561..2068064) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 2068073 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2068128..2068147) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068128) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2068162..2068169) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2068207..2068653) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(2068207..2068653) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 2068656 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(2068708..2069247) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(2068708..2069247) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(2068721) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2069280..2069298) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2069291) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(2069310..2069318) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2069319..2070590) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(2069319..2070590) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(2070591..2070658) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2070655..2070674) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2070658) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2070688..2070695) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2070725..2070744) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2070731) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(2070733..2070877) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2070755..2070762) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2070859..2070877) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2070877) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2070893..2070898) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2070926..2072212) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(2070926..2072212) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(2070949) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2072223..2073338) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(2072223..2073338) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(2073387..2074469) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(2073387..2074469) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(2074480..2075283) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(2074480..2075283) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(2074968..2074987) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2074985) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2074999..2075006) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2075276..2076478) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(2075276..2076478) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(2076459..2077106) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(2076459..2077106) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(2076553) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(2076729..2076732) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2076729) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(2076949) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 2077111..2077863 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(2077111..2077863) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(2077111..2077863) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(2077144..2077146) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2077147 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(2077253,2077256) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077267,2077269) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077269,2077271) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077294,2077296) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077296,2077300) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077302,2077304) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077311,2077313) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077326,2077328) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077329,2077331) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077334,2077336) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077344,2077346) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077347,2077349) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077350,2077352) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077356,2077358) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077382,2077384) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077414,2077416) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077467,2077469) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077515,2077517) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077530,2077534) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077548,2077550) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077557,2077559) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077569,2077571) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077634,2077636) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077644,2077646) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077652,2077655) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077672,2077674) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077688,2077690) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077716,2077718) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077731,2077733) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077756,2077758) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077773,2077775) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2077788,2077790) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(2077856..2078872) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(2077856..2078872) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(2078844..2080391) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(2078844..2080391) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(2080470..2080601) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2080513) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2080592..2080611) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2080601) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(2080607..2080990) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(2080607..2080990) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(2080626..2080633) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2080987..2082075) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(2080987..2082075) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(2081116..2081131) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2081129) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2081144..2081152) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2082075..2083247) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(2082075..2083247) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(2083282..2083301) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2083299) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2083314..2083321) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2083322..2084092) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(2083322..2084092) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(2084118..2084137) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2084135) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2084149..2084155) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2084167..2084328) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2084210) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(2084329..2084778) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(2084329..2084778) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(2084821..2084840) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2084828) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2084853..2084860) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2084894..2085940) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(2084894..2085940) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(2085882..2086583) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(2085882..2086583) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(2086590..2087345) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(2086590..2087345) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(2087346..2087431) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2087420..2087439) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2087431) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2087450..2087457) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2087509..2087736) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(2087509..2087736) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(2087530) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(2087758..2088330) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(2087758..2088330) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(2088359..2088378) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2088369) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(2088371..2088454) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2088391..2088397) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2088499) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(2088518..2088796) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(2088518..2088796) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(2088797..2089022) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2089004..2089023) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2089022) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2089040..2089045) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2089170..2090648) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(2089170..2090648) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(2089183) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2090649..2090810) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2090797..2090815) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2090822) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(2090829..2091563) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(2090829..2091563) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(2090830..2090835) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2090855) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(2091585..2091788) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(2091585..2091788) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(2091824..2091843) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091845) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091857..2091864) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2091910..2092109) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2091953) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2092084..2092103) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092109) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2092117..2092126) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092126..2093163) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(2092126..2093163) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(2093181..2094491) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(2093181..2094491) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(2094492..2094616) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2094602..2094621) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2094616) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094636..2094639) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2094645..2094839) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(2094645..2094839) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(2094836..2095729) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(2094836..2095729) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(2095726..2096325) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(2095726..2096325) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 2096198..2096204 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2096213..2096396 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2096215 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2096218..2096229 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2096336..2096354) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2096355) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2096370..2096375) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2096403..2096534 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 2096403..2096534 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 2096522 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2096577..2097626) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(2096577..2097626) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(2096597) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2097501) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(2097639..2098787) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(2097639..2098787) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 2097968..2097971 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2097995 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2098061 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2098765 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(2098788..2098927) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2098926..2098945) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098927) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2098929..2099019) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2098960..2098967) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2099020..2099694) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(2099020..2099694) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(2099695..2099772) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2099773..2099949) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(2099773..2099949) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(2099961..2099979) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099978) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2099994..2100000) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2099994..2100647) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(2099994..2100647) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(2100677..2100696) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2100690) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2100712..2100716) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2100740..2102092) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(2100740..2102092) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(2100755) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2102127..2103044) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(2102127..2103044) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(2102515) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(2102666..2102673) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2102669) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2103082..2103093) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103091) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2103107..2103113) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2103183..2103839) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(2103183..2103839) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(2103197) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2103864..2103883) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2103879) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2103959..2104933) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(2103959..2104933) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(2103967) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 2104787..2104792 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2104808..2104826 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2104818..2105011 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2104818 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 2104969 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2105042..2106325) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(2105042..2106325) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(2105045) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 2105083..2105089 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2105101..2105105 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2105101 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2106368..2106387) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106389) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106402..2106409) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2106481..2107065) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(2106481..2107065) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(2106483) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(2107066..2107147) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2107140..2107159) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2107147) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(2107173..2107180) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2107224..2108003) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(2107224..2108003) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(2108029..2108044) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2108040) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(2108056..2108065) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2108089..2108532) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(2108089..2108532) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(2108106) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2108595..2109317) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(2108595..2109317) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(2108876) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(2109268..2109837) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(2109268..2109837) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(2109586..2109604) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109602) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2109619..2109625) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2109856..2110602 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2109897..2111387) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(2109897..2111387) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(2111380..2112438) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(2111380..2112438) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 2111728..2111737 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2111748..2112538 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2111748 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2111750..2111769 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2112479..2112498) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2112502) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2112510..2112517) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2112516..2112522 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2112536..2112555 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2112540..2112609 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2112540 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 2112589..2112596 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2112611..2112703 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2112611..2112630 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2112611 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 2112704..2112952 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 2112704..2112952 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 2112936 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2112992..2113564) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(2112992..2113564) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(2113012) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2113556..2113863) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(2113556..2113863) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(2113565..2113669) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2113862..2113881) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2113878) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2113895..2113901) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2113990..2113997 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2114008 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2114012..2114031 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2114061..2115638 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 2114061..2115638 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 2115620 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(2115681..2116448) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(2115681..2116448) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(2115696) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 2115950..2116562 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2116475..2116494) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116488) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2116509..2116512) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2116522 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(2116560..2117666) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(2116560..2117666) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(2116577) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(2117602..2118186) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(2117602..2118186) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 2117980..2117985 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2117996 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2118000..2118004 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2118137..2118142 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2118154 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2118158..2118176 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2118194 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2118235..2118254) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2118239..2118346 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2118243) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2118267..2118274) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2118302 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2118331..2118389) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2118362) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2118390..2120159) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(2118390..2120159) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(2118446) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2120156..2120878) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(2120156..2120878) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(2120879..2120958) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2120959..2122134) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(2120959..2122134) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(2122154..2123782) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(2122154..2123782) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(2123779..2124318) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(2123779..2124318) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(2124319..2124412) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2124413..2125147) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(2124413..2125147) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(2125156..2125175) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2125179) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2125190..2125194) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2125239..2125775) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(2125239..2125775) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(2125244..2125263) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2125248) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2125278..2125285) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2125780..2126370) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(2125780..2126370) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(2126358..2127506) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(2126358..2127506) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(2127528..2127546) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127535) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2127561..2127566) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2127629..2128168) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(2127629..2128168) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(2127642) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2128177..2128194) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2128192) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2128209..2128214) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2128223..2128816) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(2128223..2128816) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(2128806..2129561) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(2128806..2129561) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 2129405..2129414 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2129427..2129446 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2129436 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2129607..2129626) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2129622) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2129640..2129647) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2129787..2129794 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2129805..2129824 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2129810 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 2129842..2130366 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 2129842..2130366 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(2130380..2130754) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(2130380..2130754) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(2130396) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2130816..2130835) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130828) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2130847..2130854) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2130867..2131331) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(2130867..2131331) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 2131202..2131206 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2131220..2131224 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2131223 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2131364..2132560) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(2131364..2132560) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(2132575..2133222) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(2132575..2133222) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(2133233..2134318) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(2133233..2134318) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(2134319..2134447) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2134448..2134592) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(2134448..2134592) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(2134609..2134628) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2134619) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2134643..2134650) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2134712..2135056) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(2134712..2135056) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(2134727) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2135088..2135106) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2135101) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2135115..2135120 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2135121..2135127) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2135135..2136057 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2135135 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2135136..2135154 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2135142..2135157) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2135145) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2135147..2135213) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2135170..2135179) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2135208..2135216) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2135213) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2135230..2135238) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2135291..2135845) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(2135291..2135845) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(2135301) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2135871..2135890) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2135889) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2135891..2136290) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2135902..2135908) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2136112..2136348 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 2136112..2136348 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(2136291..2136497) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(2136291..2136497) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(2136530..2136549) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2136552) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(2136606..2136860) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(2136606..2136860) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 2136740..2136749 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2136751..2137140) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(2136751..2137140) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 2136763..2137834 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2136763..2136782 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136763 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2137118..2137321) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(2137118..2137321) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 2137730..2137846 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 2137730..2137846 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 2137797 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 2137923..2137932 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2137945..2137964 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2137945 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 2137987..2138199 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 2137987..2138199 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 2138193 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(2138335) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2138335..2138766) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(2138335..2138766) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(2138767..2138853) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2138836..2138855) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138853) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2138869..2138874) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2138903..2138912 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2138922..2139019 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2138922 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2138925..2138940 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2139020..2139892 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 2139020..2139892 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 2139799 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2139865 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2139922..2141241) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(2139922..2141241) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(2139942) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2141242..2141306) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2141302..2141321) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141306) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2141336..2141343) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2141347..2142828) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" /label="spoVAF CDS" gene complement(2141347..2142828) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /label="spoVAF gene" misc_feature complement(2142053..2142072) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2142057) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2142779..2143390) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" /label="spoVAEA CDS" gene complement(2142779..2143390) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /label="spoVAEA gene" CDS complement(2143398..2143748) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" /label="spoVAEB CDS" gene complement(2143398..2143748) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /label="spoVAEB gene" CDS complement(2143750..2144766) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" /label="spoVAD CDS" gene complement(2143750..2144766) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /label="spoVAD gene" promotor_-35 2144246..2144253 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2144267..2144286 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2144289 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2144779..2145231) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" /label="spoVAC CDS" gene complement(2144779..2145231) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /label="spoVAC gene" CDS complement(2145244..2145669) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" /label="spoVAB CDS" gene complement(2145244..2145669) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /label="spoVAB gene" CDS complement(2145659..2146279) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" /label="spoVAA CDS" gene complement(2145659..2146279) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /label="spoVAA gene" promotor_-10 complement(2146310..2146321) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146320) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146335..2146341) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2146404..2147171) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" /label="sigF CDS" gene complement(2146404..2147171) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /label="sigF gene" downshifts complement(2146434) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2147183..2147623) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" /label="spoIIAB CDS" gene complement(2147183..2147623) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /label="spoIIAB gene" CDS complement(2147620..2147973) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" /label="spoIIAA CDS" gene complement(2147620..2147973) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /label="spoIIAA gene" promotor_-10 complement(2147998..2148016) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2148009) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2148011..2148068) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2148028..2148036) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2148069..2149238) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(2148069..2149238) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2149267..2149278) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149282) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2149292..2149298) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2149384) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2149393..2150208) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2149393..2150208) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2150221..2151405) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2150221..2151405) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2151454..2151473) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151472) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2151474..2151565) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2151489..2151496) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2151566..2152456) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2151566..2152456) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2152464..2152691) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2152464..2152691) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2152594..2152613) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152605) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152627..2152634) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2152684) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2152693..2152711) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2152721..2152739) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2152727..2152733) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2152734) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152756..2152761) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2152816) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2152816..2153265) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2152816..2153265) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2153289..2153308) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2153299) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2153301..2153377) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2153324..2153328) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2153378..2154022) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2153378..2154022) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2154053..2154071) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2154070) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2154086..2154091) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2154123..2154338) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2154123..2154338) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2154203) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2154438..2155757) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2154438..2155757) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2154445) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2155775..2157181) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2155775..2157181) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2157229..2157248) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157238) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2157240..2157321) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2157263..2157270) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2157322..2158749) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2157322..2158749) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2158794..2159783) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2158794..2159783) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2159784..2159863) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2159845..2159864) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159863) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2159865..2160185) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2159879..2159886) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2159904..2159911 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2159924..2159943 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2159926 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2159965..2160315 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2159965..2160315 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2160187..2160323) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2160230) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2160324..2161487) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2160324..2161487) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2161484..2162041) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2161484..2162041) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2161971..2162071) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2162011) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2162055..2162060 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2162076..2162094 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2162078..2162092) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2162082 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2162089..2162263 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2162094..2162097) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2162097) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2162116..2162238 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2162116..2162238 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2162239..2162246 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2162260..2162279 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2162265 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2162301..2163221 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2162301..2163221 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2163210 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2163253..2163477) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2163253..2163477) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2163310) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2163500..2163519) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2163507) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2163534..2163541) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2163556..2163563 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2163578..2163597 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2163585 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2163639..2164556 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2163639..2164556 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2164531 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2164596..2164835) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2164596..2164835) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2164607) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2164848..2165171) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2164848..2165171) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2164914..2164933) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164915) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2164947..2164954) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2165168..2166199) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2165168..2166199) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2165195..2165214) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165202) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2165225..2165232) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2166192..2166536) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2166192..2166536) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2166546..2167016) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2166546..2167016) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2167017..2167093) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2167017 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2167068..2167087) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167093) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2167095..2167201) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2167102..2167109) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2167202..2167540) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2167202..2167540) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2167537..2168775) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2167537..2168775) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2167699..2167700 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2167710 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2167765 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2168800..2168818) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2168809) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2168835..2168840) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2168880..2168883 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2168898..2168917 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2168907 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2168941..2169147 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2168941..2169147 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2169630..2169633 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2169648..2169667 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2169664 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2169696..2170928 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2169696..2170928 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2170775..2171137 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2170775..2171137 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2170954..2171133) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2170987) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2171134..2171520) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2171134..2171520) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2171524..2172483) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2171524..2172483) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2172484..2172554) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2172555..2173901) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2172555..2173901) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2173902..2173976) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2173977..2174756) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2173977..2174756) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2174762..2175721) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2174762..2175721) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2175743..2175762) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175762) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2175777..2175784) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2175818..2175825 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2175839..2176125 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2175839 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2175841..2175860 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2175855..2176100 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2175855..2176100 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2176126..2176962 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2176126..2176962 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2176960 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2177003..2178646) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2177003..2178646) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2177015) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2178664..2178670 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2178677 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2178684..2178695 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2178702..2178721) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2178707) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2178753..2178760 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2178774..2178793 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2178776 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2178818..2179834 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2178818..2179834 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2179821 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2179883..2179892 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2179905..2179920 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2179909 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2179944..2180705 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2179944..2180705 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2180613 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2180701 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2180733..2180933) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2180749..2180874) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2180749..2180874) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2180776) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2180867..2180899) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2180867..2180899) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2180927..2180946) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2180933) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2180959..2180966) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2180981..2181904) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2180981..2181904) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2181930..2181949) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2181943) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2181963..2181968) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2182042..2182049 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2182063..2182082 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2182065..2182130 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2182065 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2182131..2183600 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2182131..2183600 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2183583 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2183608..2183647 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2183620,2183623) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2183628,2183629) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2183640,2183641) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2183649 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2183723..2185132) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2183723..2185132) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2183740) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2183813) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2185196..2185214) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2185198) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2185242..2186486) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2185242..2186486) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2186487..2186761) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2186507..2186514 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2186528..2186547 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2186528 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2186559..2186846 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2186559..2186846 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2186743..2186762) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2186763) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2186778..2186781) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2186877..2187704 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2186877..2187704 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2187521 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2187697 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2187709..2188629) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2187752) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2187822..2187828 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2187842..2187860 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2187851 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2187884..2188612 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2187884..2188612 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2188653..2189768) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2188653..2189768) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2188674) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2189786..2191309) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2189786..2191309) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2190892..2190911) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2190914) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2190926..2190930) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2191302..2191724) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2191302..2191724) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2191753..2191760 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2191774..2191793 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2191788..2191941 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2191788 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2191898 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2191926..2192456) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2191926..2192456) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2191943..2192578 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2192473..2192484) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2192480) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2192499..2192505) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2192508..2193476) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2192508..2193476) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2192524) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2193547..2194269) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2193547..2194269) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2193558) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2194262..2194921) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2194262..2194921) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2194922..2195001) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2195002..2195769) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2195002..2195769) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2195819..2195838) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2195834) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2195853..2195860) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2196037..2196474) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2196037..2196474) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2196046) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2196498..2196517) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2196519) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2196532..2196539) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2196572..2196578 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2196591 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2196593..2196611 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2196635..2197528 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2196635..2197528 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2197561..2197568 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2197584..2197603 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2197592 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2197629..2198798 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2197629..2198798 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2198781 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2198871..2199707 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2198871..2199707 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2199705 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2199769) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2199769..2201043) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2199769..2201043) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2201066..2202049) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2201066..2202049) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2202063..2203055) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2202063..2203055) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2203077..2204501) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2203077..2204501) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2204522..2205613) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2204522..2205613) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2205632..2206726) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2205632..2206726) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2206738..2207637) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2206738..2207637) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2207673..2207692) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2207678) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2207680..2207761) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2207762..2209840) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2207762..2209840) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2209900..2209919) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209917) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2209927..2209934 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2209936..2209939) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2209948..2209967 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2209955 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2209993..2210229 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2209993..2210229 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2210220 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2210271..2211176) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2210271..2211176) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2210274) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2211194..2212612) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2211194..2212612) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2211489..2211508) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2211506) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2212627..2213745) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2212627..2213745) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2213779..2214918) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2213779..2214918) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2214946..2215809) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2214946..2215809) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2215834..2217015) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2215834..2217015) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2216595) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2216702..2216708) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2216705) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2216929..2217029) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2216969) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2217062..2217080) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217080) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217096..2217101) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2217142..2217873) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2217142..2217873) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2217149) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2217896..2217915) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217907) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217930..2217933) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2217952..2218572) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2217952..2218572) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2218587..2218880) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2218587..2218880) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2218900..2218919) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2218906) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2218934..2218941) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2219136..2219143 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2219157..2219176 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2219174..2219379 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2219174 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2219188..2219340 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2219188..2219340 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2219348..2219355 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2219370..2219389 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2219381 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2219413..2220531 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2219413..2220531 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2220516 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2220558..2220728) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2220601) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2220712..2220727) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220728) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2220730..2220858) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2220739..2220748) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2220857..2220876) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220880) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220890..2220898) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2220990) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2220996..2221799) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2220996..2221799) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2221842..2221860) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2221848) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2221850..2222002) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2221871..2221879) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2221998..2222017) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2222010) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2222029..2222036) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2222075..2223355) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" /label="spoIVB CDS" gene complement(2222075..2223355) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /label="spoIVB gene" downshifts complement(2222090) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2223416..2223427) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223430) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2223442..2223448) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2223530..2225260) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2223530..2225260) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2223545) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2225297..2225746) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2225297..2225746) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2225747..2225832) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2225844..2226689) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2225844..2226689) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2225877) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2226686..2228587) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2226686..2228587) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2227795..2227801 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2227816..2227827 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2227824 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2228588..2228716) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2228711..2228730) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2228716) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2228745..2228751) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2228762..2229652) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2228762..2229652) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2229642..2229896) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2229642..2229896) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2229893..2231239) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2229893..2231239) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2231240..2231376) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2231377..2232228) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2231377..2232228) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2232240..2232635) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2232240..2232635) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2232678..2232697) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2232697) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2232699..2232861) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2232899..2233306) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2232899..2233306) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2232906) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2233327..2234679) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2233327..2234679) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2234208..2234227) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2234215) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2234242..2234248) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2234691..2235170) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2234691..2235170) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2235229..2235248) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2235240) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2235262..2235269) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2235326..2235982) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2235326..2235982) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2235333) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2235983..2236672) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2235983..2236672) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2236665..2237285) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2236665..2237285) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2236991..2237009) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237009) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2237025..2237030) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2237299..2238498) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2237299..2238498) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2238517..2238918) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2238517..2238918) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2238925..2239131) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2238925..2239131) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2239154..2239669) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2239154..2239669) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2239663..2240586) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2239663..2240586) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2240587..2240661) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2240662..2240943) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2240662..2240943) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2240963..2240981) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2240986) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2240997..2241002) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2241088..2241645) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2241088..2241645) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2241100) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2241670..2242731) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2241670..2242731) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2242728..2243174) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2242728..2243174) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2243223..2243242) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2243239) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2243255..2243262) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2243261..2243797) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2243261..2243797) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2243810..2243821) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2243819) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2243835..2243841) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2243867..2243873 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2243886 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2243888..2243906 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2243943..2243946 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2243961..2243980 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2243972 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2244024..2244980 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2244024..2244980 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2245020..2245415 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2245020..2245415 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2245298..2245398 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2245358 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2245401 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2245412..2246287) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2245412..2246287) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2246314..2246332) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246331) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2246348..2246353) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2246413..2246841) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2246413..2246841) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2246440) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2246876..2246895) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246884) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2246911..2246915) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2246941..2247777) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2246941..2247777) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2247801..2247820) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2247812) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2247814..2248358) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2247834..2247841) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2247858..2247863 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2247877..2247896 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2247877 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2247888..2247967 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2247968..2248348 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2247968..2248348 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2248284 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2248328 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2248383..2249849) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2248383..2249849) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2248403) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2249842..2251188) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2249842..2251188) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2251218..2252306) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2251218..2252306) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2252380..2252579) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2252380..2252579) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2252430) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2252580..2252650) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2252583..2252588 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2252604..2252622 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2252608 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2252618..2252747 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2252636..2252655) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2252650) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2252669..2252676) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2252748..2254421 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2252748..2254421 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2254442..2255236 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2254442..2255236 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2254772..2254773 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2254778 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2255260..2255263 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2255279..2255298 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2255280..2255418 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2255280 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2255419..2255592 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2255419..2255592 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2255577..2255581 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2255594..2255613 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2255594 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2255626..2255961 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2255626..2255961 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2255938 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2256028 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2256054..2256839) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" /label="tasA CDS" gene complement(2256054..2256839) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /label="tasA gene" downshifts complement(2256060) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2256892..2256909) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2256896) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2256903..2257475) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" /label="sipW CDS" gene complement(2256903..2257475) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /label="sipW gene" CDS complement(2257459..2258220) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" /label="tapA CDS" gene complement(2257459..2258220) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /label="tapA gene" promotor_-10 complement(2258280..2258299) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2258298) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="upshifts" promotor_-35 complement(2258313..2258320) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2258442..2258448 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2258449 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2258462..2258473 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2258492..2258818 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2258492..2258818 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2258635..2258859) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2258678) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2258800 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2258860..2259039) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2258860..2259039) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2259058..2259076) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2259073) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2259091..2259097) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2259110..2259484) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2259110..2259484) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2259485..2259868) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2259485..2259868) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2259894..2260241) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2259894..2260241) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2260225..2260656) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2260225..2260656) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2260646..2260942) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2260646..2260942) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2260956..2261927) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2260956..2261927) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2261980..2263050) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2261980..2263050) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2263068..2263087) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2263084) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2263101..2263108) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2263233..2263461) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2263274) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2263462..2264415) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2263462..2264415) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2264439..2264458) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264460) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2264472..2264478) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2264498..2264504 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2264519..2264537 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2264537 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2264558..2265886 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2264558..2265886 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2265887..2266861 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2265939..2266775) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2265939..2266775) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2266776..2266960) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2266862..2266932 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2266862..2266932 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2266999..2267379) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2266999..2267379) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2267005) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2267408..2267426) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267427) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267441..2267447) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2267466..2267471 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2267487..2267505 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2267496 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2267546..2267553 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2267568 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2267569..2267588 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2267611..2267856 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2267611..2267856 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2267753 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2267842 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2267887..2268642 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2267896..2268531) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2267896..2268531) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2267921) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2268553..2268572) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2268570) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2268586..2268593) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2268610..2268617 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2268632..2268651 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2268644 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2268664) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2268666..2268680) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2268688..2268692) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2268688..2268861 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2268688..2268861 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2268849 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2268893..2269207) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2268893..2269207) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2268894..2269961 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2268907) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2269210..2270271) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2269210..2270271) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2270333..2271463) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2270333..2271463) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2271471..2271489) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2271503) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2271505..2271510) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2271546..2273462) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2271546..2273462) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2271573) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2272578..2272584 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2272597..2273626 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2272597 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2272600..2272618 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2273463..2273529) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2273523..2273542) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2273529) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2273557..2273564) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2273579..2274544) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2273579..2274544) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2274555..2274770) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2274555..2274770) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2274771..2274879) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2274880..2276403) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2274880..2276403) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2276421..2276440) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276434) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2276455..2276462) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2276493..2276666) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2276493..2276666) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2276520) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2276682..2276693) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276694) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2276707..2276713) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2276733..2277296) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2276733..2277296) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2277297..2277380) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2277381..2277530) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2277381..2277530) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2277427) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2277567..2277586) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2277577) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2277602..2277605) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2277614..2278693) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2277614..2278693) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2278690..2279160) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2278690..2279160) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2279105..2279113 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2279127..2279135 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2279128..2279301 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2279129 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2279196..2279215) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279208) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279227..2279234) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2279273..2279277 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2279293..2279312 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2279303 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2279340..2279693 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2279340..2279693 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2279690..2280154 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2279690..2280154 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2280140 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2280183..2280965) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2280183..2280965) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2280194) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2280976..2281785) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2280976..2281785) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2281806..2282690) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2281806..2282690) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2282690..2283619) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2282690..2283619) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2283688..2284590) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2283688..2284590) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2284645) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2284653..2284669) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2284680..2284682) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2284699,2284701) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2284745..2286895) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2284745..2286895) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2284755) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2285489..2285507) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285497) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285523..2285529) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2286184..2286203) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2286201) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2286217..2286226) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2286945..2286964) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2286950) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2286980..2286984) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2287009..2288301) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2287009..2288301) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2288324..2288335) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288335) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288349..2288355) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2288408..2289016) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2288408..2289016) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2288423) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2289068..2289087) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2289079) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2289081..2289149) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2289102..2289109) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2289140..2289158) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2289149) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2289173..2289179) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2289195..2289677) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2289195..2289677) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2289678..2289970) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2289720..2289726 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2289741..2289760 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2289754 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2289787..2290554 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2289787..2290554 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2289968..2289986) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2289970) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2289972..2290908) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2290000..2290006) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2290555..2290985 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2290942 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2290953) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2290970..2291398) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2290970..2291398) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2291394..2291398 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2291408..2291422 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2291417 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2291421..2291440) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2291444) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2291455..2291462) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2291613..2291618 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2291634..2291652 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2291646 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2291675..2291974 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2291675..2291974 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2291987..2291994 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292009..2292028 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2292020..2292096 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2292020 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2292097..2293230 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2292097..2293230 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2293211 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2293256..2293645) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2293256..2293645) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2293282) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2293676..2293687) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293680) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2293701..2293707) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2293720..2293727 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2293738..2293757 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2293739 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2293778..2294359 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2293778..2294359 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2294357 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2294402..2295010 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2294402..2294839) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2294402..2294839) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2294406) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2294840..2294934) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2294930..2294949) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294934) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294964..2294971) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2294977..2295858) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2294977..2295858) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2295854..2295859 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2295875..2295893 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2295891 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2295896..2295915) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2295902) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2295904..2296231) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2295920..2295929 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2295936 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2295942..2295961 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2295974..2296228 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2295974..2296228 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2296215 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2296255..2297148) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2296255..2297148) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2296260..2297061 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2296276) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2297158..2298474) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2297158..2298474) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2298510..2298529) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298521) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2298545..2298549) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2298578..2298587 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2298599 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2298601..2298620 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2298643..2299386 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2298643..2299386 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2299368 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2299390..2299397 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2299411..2299430 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2299413..2299508 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2299413 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2299509..2300453 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2299509..2300453 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2300424 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2300476..2301597) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2300476..2301597) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2300501) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2301590..2302240) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2301590..2302240) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2302241..2302349) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2302337..2302356) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302349) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2302351..2302464) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2302372..2302376) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2302497..2302859) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2302497..2302859) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2302509) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2302855..2302859 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2302867..2302881 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2302888 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2302896..2302915) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302898) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2302900..2303021) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2302927..2302934) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2303010..2303029) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2303018..2303037 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303021) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2303023..2303162) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2303024..2303128 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2303024 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2303043..2303049) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2303092..2303099 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2303113..2303132 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2303130..2305279 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2303130 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2303188..2304303) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2303188..2304303) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2303207) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2304304..2304501) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2304502..2306313) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2304502..2306313) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2305908..2305914 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2305924 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2305926..2305945 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2305953..2306249 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2305953..2306249 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2306347..2306841) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2306347..2306841) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2306814..2306832) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2306825) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2306842..2306955) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2306844..2306852) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2306850..2306855 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2306871..2306889 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2306886 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2306940..2306958) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2306955) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2306957..2307034) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2306974..2306979) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2307000..2307019) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2307034) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2307035..2307038) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2307095..2307907) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2307095..2307907) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2307933..2308571) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2307933..2308571) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2308572..2308703) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2308697..2308716) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2308704..2310743) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2308704..2310743) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2308706) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2308731..2308738) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2308750) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2308816) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2310736..2311623) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2310736..2311623) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2311706..2311880) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2311706..2311880) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2311740) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2311855..2311860 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2311876..2311894 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2311884..2311903) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2311886..2313298 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2311886 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2311896) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2311918..2311925) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2311920..2312687) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2311920..2312687) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2312724..2312867) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2312724..2312867) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2312868..2313014) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2313015..2313920) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2313015..2313920) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2313901..2314311) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2313901..2314311) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2314349..2314368) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2314360) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2314362..2314429) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2314383..2314386) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2314430..2314801) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2314430..2314801) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2314782..2315255) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2314782..2315255) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2315256..2317391) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2315256..2317391) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2317235..2317240 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2317255 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2317256..2317274 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2317470..2318429) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2317470..2318429) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2317485) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2318426..2319622) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2318426..2319622) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2318493..2318512) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2318498) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2318526..2318533) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2318573..2318591) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2318585) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2318606..2318612) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2318800) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2318814..2318825) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2318840..2318846) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2319641..2319922) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2319641..2319922) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2319979..2320398) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2319979..2320398) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2319993) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2320423..2321418) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2320423..2321418) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2321440..2322753) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2321440..2322753) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2322789..2322804) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2322806) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2322817..2322826) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2322884..2323330) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2322884..2323330) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2322897) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2323095) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2323345..2323518) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2323345..2323518) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2323454..2323458 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2323459 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2323579..2323598) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2323594) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2323612..2323619) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2323637..2323642 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2323657 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2323658..2323676 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2323691..2324614 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2323691..2324614 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2324651..2326006) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2324651..2326006) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2324657) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2326006..2326776) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2326006..2326776) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2326799..2327734) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2326799..2327734) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2327759..2328886) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2327759..2328886) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2328803..2328806 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2328814 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2328887..2329064) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2328926..2329016 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2328926..2329016 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2329086..2330921) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2329086..2330921) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2329109) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2330945..2331508) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2330945..2331508) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2331509..2331579) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2331580..2332611) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2331580..2332611) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2332652..2332671) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2332665) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2332686..2332693) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2332692..2333831) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2332692..2333831) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2333704..2333715) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2333708) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2333729..2333735) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2333884..2335722) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2333884..2335722) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2333906) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2335757..2335776) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2335774) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2335792..2335796) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2335856..2336194) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2335856..2336194) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2335862) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2336211..2337416) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2336211..2337416) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2337436..2337454) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337448) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2337470..2337475) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2337479..2338585) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2337479..2338585) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2338613..2338624) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338620) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2338639..2338645) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2338684..2338687 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2338700 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2338703..2338722 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2338714..2338788 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2338789..2339055 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2338789..2339055 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2339044 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2339070..2340113) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2339070..2340113) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2339115) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2340142..2340161) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2340153..2340302) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2340153..2340302) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2340154) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2340175..2340179) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2340177..2340516) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2340220) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2340289..2340295 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2340309..2340328 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2340310 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2340343..2340477 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2340343..2340477 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2340471 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2340517..2342847) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2340517..2342847) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2340534..2340553) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2340550) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2340567..2340576) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2342851..2343420) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2342851..2343420) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2343447..2343466) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343457) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2343481..2343488) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2343487..2344104) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2343487..2344104) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2344125..2344130 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2344142 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2344146..2344164 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2344165..2344179) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344167) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2344169..2345016) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2344188..2344192) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2344188..2345009 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2344188..2345009 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2345004..2345023) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2345010..2345090 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2345017) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2345037..2345044) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2345050 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2345075..2345818) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2345075..2345818) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2345105) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2345815..2346171) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2345815..2346171) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2346189..2346749) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2346189..2346749) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2346739..2347308) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2346739..2347308) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2347320..2347610) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2347320..2347610) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2347604..2348446) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2347604..2348446) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2348438 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2348464..2349564) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2348464..2349564) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2349568..2350086) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2349568..2350086) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2349996..2350013) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350010) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2350029..2350032) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2350087..2350648) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2350120) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2350311..2350318 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2350329..2350429 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2350329..2350348 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2350329 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2350379..2350637) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2350379..2350637) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2350430..2350588 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2350430..2350588 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2350589..2350835 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2350636..2350655) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350647) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2350671..2350675) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2350699..2350846) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2350736) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2350792 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2350837..2351890 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2350841..2350860) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350846) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2350873..2350882) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2350894..2351625) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" /label="yqeF CDS" gene complement(2350894..2351625) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /label="yqeF gene" promotor_-10 complement(2351644..2351663) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2351660) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2351662..2351770) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2351677..2351683) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2351771..2351789) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2351792) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2351804..2351809) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2351877..2352629) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" /label="cwlH CDS" gene complement(2351877..2352629) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /label="cwlH gene" downshifts complement(2351880) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2352008..2352014 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2352028..2352046 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2352035 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2352639..2352658) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2352658) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2352672..2352680) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2352724..2352731 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2352746..2352765 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2352750..2352815 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2352750 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="upshifts" CDS 2352816..2353442 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" /label="yqeD CDS" gene 2352816..2353442 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /label="yqeD gene" downshifts 2353410 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2353461..2354354) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" /label="yqeC CDS" gene complement(2353461..2354354) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /label="yqeC gene" downshifts complement(2353486) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" /label="downshifts" promotor_-35 2354537..2354543 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2354555..2354574 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2354555 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="upshifts" CDS 2354606..2355328 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" /label="yqeB CDS" gene 2354606..2355328 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /label="yqeB gene" CDS complement(2355361..2355771) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" /label="nucB CDS" gene complement(2355361..2355771) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /label="nucB gene" downshifts complement(2355386) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2355791..2355809) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2355793) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2355825..2355830) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2355894..2355902 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2355915 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2355916..2355935 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2355967..2356437 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" /label="sigKn CDS" gene 2355967..2356437 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo /label="sigKn gene" downshifts 2356157 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 2356289 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2356345..2357847) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" /label="spoIVCA CDS" gene complement(2356345..2357847) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /label="spoIVCA gene" downshifts complement(2356361) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2357954..2357972) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357972) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2357974..2358275) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2357989..2357994) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2358296..2358715) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" /label="arsC CDS" gene complement(2358296..2358715) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /label="arsC gene" downshifts complement(2358320) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" /label="downshifts" CDS complement(2358727..>2358855) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2358727..>2358855) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2358851,2358858) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2358852..2358857 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2358853..2359239 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2358853..2359239 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2359206..2359224) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2359221..2359637 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" /label="sigKc CDS" gene 2359221..2359637 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo /label="sigKc gene" misc_feature 2359226..2359240 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2359234) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 2359245 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="upshifts" downshifts 2359621 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS 2359637..2359753 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" /label="hypothetical protein CDS" gene 2359637..2359753 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /label="gene" S_feature 2359666..2361000 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2359784) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(2359862..2360026) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" /label="yrkS CDS" gene complement(2359862..2360026) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /label="yrkS gene" promotor_-10 complement(2359956..2359975) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2359982) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2359990..2359997) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2360160) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" CDS complement(2360571..2360987) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2360571..2360987) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2361033..2362331) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2361033..2362331) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2362318..2363013) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2362318..2363013) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2363079..2363096) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2363088) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2363174..2363180 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2363187..2363205 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2363202 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2363281..2364498 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2363281..2364498 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2363740..2363747 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2363762..2363781 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2363778 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2364417..2364665 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2364417..2364665 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2364594..2365641) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2365010..2365567 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2365010..2365567 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2365568..2365690 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2365643..2366057) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2365686) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2366058..2366582) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2366058..2366582) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2366430..2366437 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2366448..2366467 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2366462 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2366583..2366670) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2366665..2366684) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366670) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2366672..2366825) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2366699..2366706) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366826..2367302) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" /label="yrkK CDS" gene complement(2366826..2367302) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /label="yrkK gene" promotor_-10 complement(2367338..2367357) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2367352) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2367354..2367884) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2367371..2367378) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2367885..2368670) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" /label="yrkJ CDS" gene complement(2367885..2368670) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /label="yrkJ gene" CDS complement(2368731..2368958) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" /label="yrkI CDS" gene complement(2368731..2368958) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /label="yrkI gene" downshifts complement(2368755) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" /label="downshifts" CDS complement(2368992..2370125) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" /label="yrkH CDS" gene complement(2368992..2370125) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /label="yrkH gene" misc_feature complement(2369827..2369842) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2369838) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2370126..2370459) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2370460..2371017) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" /label="yrkF CDS" gene complement(2370460..2371017) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /label="yrkF gene" S_feature complement(2371018..2371202) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2371203..2371685) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" /label="yrkE CDS" gene complement(2371203..2371685) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /label="yrkE gene" S_feature complement(2371686..2371794) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2371832..2372023) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" /label="yrkD CDS" gene complement(2371832..2372023) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /label="yrkD gene" downshifts complement(2371839) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2372024..2372113) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2372114..2372431) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" /label="yrzM CDS" gene complement(2372114..2372431) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo /label="yrzM gene" promotor_-10 complement(2372220..2372239) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372236) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2372252..2372258) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2372473..2372688) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" /label="yrzN CDS" gene complement(2372473..2372688) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo /label="yrzN gene" promotor_-10 complement(2372501..2372520) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372515) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2372535..2372542) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2372689..2372815) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2372816..2373376) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" /label="yrkC CDS" gene complement(2372816..2373376) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /label="yrkC gene" CDS complement(2373393..2373569) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" /label="hypothetical protein CDS" gene complement(2373393..2373569) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /label="gene" promotor_-10 complement(2373403..2373422) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2373414) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2373416..2373601) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2373435..2373444) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2373602..2373748) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" /label="yrkB CDS" gene complement(2373602..2373748) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /label="yrkB gene" CDS complement(2373918..2374739) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" /label="bltR CDS" gene complement(2373918..2374739) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /label="bltR gene" promotor_-35 2374747..2374754 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2374749..2374768) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2374766) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2374768..2376772) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2374770..2374789 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2374778 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="upshifts" CDS 2374856..2376058 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" /label="blt CDS" gene 2374856..2376058 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /label="blt gene" CDS 2376227..2376685 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" /label="bltD CDS" gene 2376227..2376685 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /label="bltD gene" downshifts complement(2376817) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" /label="downshifts" CDS complement(2376842..2378146) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" /label="yrkA CDS" gene complement(2376842..2378146) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /label="yrkA gene" S_feature complement(2378147..2378226) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2378212..2378231) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2378226) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2378246..2378253) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2378409..2378552) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" /label="yrzO CDS" gene complement(2378409..2378552) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /label="yrzO gene" CDS complement(2378570..2379535) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" /label="yrdR CDS" gene complement(2378570..2379535) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /label="yrdR gene" promotor_-35 2379573..2379576 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2379591..2379610 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2379618 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="upshifts" CDS 2379661..2380527 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" /label="czcR CDS" gene 2379661..2380527 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /label="czcR gene" S_feature 2380528..2380628 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2380586 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2380650..2381687) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" /label="yrdP CDS" gene complement(2380650..2381687) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /label="yrdP gene" downshifts complement(2380662) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2381688..2381774) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2381775..2382710) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" /label="czcD CDS" gene complement(2381775..2382710) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /label="czcD gene" promotor_-10 complement(2382745..2382764) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2382752) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2382754..2382837) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2382779..2382786) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2382818..2382837) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2382837) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2382851..2382858) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2382972) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS complement(2382997..2383386) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" /label="yrdN CDS" gene complement(2382997..2383386) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /label="yrdN gene" promotor_-35 2383634..2383641 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2383657..2383676 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2383666 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="upshifts" CDS 2383720..2384610 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" /label="gltR CDS" gene 2383720..2384610 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /label="gltR gene" promotor_-35 2384298..2384303 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2384319..2384337 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2384326 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2384768..2385085) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" /label="yrdK CDS" gene complement(2384768..2385085) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /label="yrdK gene" CDS complement(2385043..2386365) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" /label="brnQ CDS" gene complement(2385043..2386365) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /label="brnQ gene" CDS complement(2386530..2386862) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" /label="azlD CDS" gene complement(2386530..2386862) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /label="azlD gene" CDS complement(2386859..2387623) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" /label="azlC CDS" gene complement(2386859..2387623) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /label="azlC gene" CDS complement(2387636..2388109) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" /label="azlB CDS" gene complement(2387636..2388109) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /label="azlB gene" CDS complement(2388443..2388718) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" /label="yrdF CDS" gene complement(2388443..2388718) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /label="yrdF gene" misc_feature complement(2388730..2388749) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2388736) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2388804..2388989) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2388990..2390222) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" /label="cypA CDS" gene complement(2388990..2390222) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /label="cypA gene" CDS complement(2390272..2390430) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" /label="yrdDc CDS" gene complement(2390272..2390430) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo /label="yrdDc gene" CDS complement(2390427..2390630) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" /label="yrdDm CDS" gene complement(2390427..2390630) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo /label="yrdDm gene" promotor_-10 complement(2390591..2390609) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2390608) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2390615..2390764) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" /label="yrdDn CDS" gene complement(2390615..2390764) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo /label="yrdDn gene" promotor_-35 complement(2390624..2390629) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2390848) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2390863..2391426) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" /label="yrdC CDS" gene complement(2390863..2391426) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /label="yrdC gene" downshifts 2391344 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2391456..2391475) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391464) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2391490..2391497) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2391655..2392026) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" /label="yrdB CDS" gene complement(2391655..2392026) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /label="yrdB gene" S_feature complement(2392027..2392256) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2392238..2392257) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2392254) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="upshifts" promotor_-35 complement(2392271..2392278) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2392822) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2392836..2393339) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" /label="yrdA CDS" gene complement(2392836..2393339) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /label="yrdA gene" S_feature complement(2393340..2393564) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2393565..2394419) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" /label="aadK CDS" gene complement(2393565..2394419) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /label="aadK gene" S_feature complement(2394420..2394522) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2394503..2394522) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2394520) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2394537..2394540) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2394691..2394698 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2394712..2394731 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2394727 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2394732..2394797 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2394798..2395841 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" /label="yrpB CDS" gene 2394798..2395841 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /label="yrpB gene" downshifts 2395839 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-35 2396126..2396133 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2396140 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="upshifts" promotor_-10 2396147..2396166 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2396191..2396988 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" /label="murI CDS" gene 2396191..2396988 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /label="murI gene" promotor_-35 2397294..2397298 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2397312..2397331 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2397322 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2397346..2397360) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397360) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2397369..2397373) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2397369..2398076 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" /label="yrpD CDS" gene 2397369..2398076 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /label="yrpD gene" downshifts 2398076 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" S_feature 2398121..2398294 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2398276..2398277 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2398293..2398312 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2398296..2398624 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2398296 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="upshifts" CDS 2398400..2398561 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" /label="hypothetical protein CDS" gene 2398400..2398561 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo /label="gene" promotor_-35 2398590..2398599 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2398612..2398631 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2398626..2398777 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2398626 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" CDS 2398652..2398729 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" /label="yrpDX CDS" gene 2398652..2398729 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /label="yrpDX gene" downshifts 2398734 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature 2398779..2398976 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2398968..2399239) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2399010) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2399016..2399177) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" /label="hypothetical protein CDS" gene complement(2399016..2399177) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /label="gene" CDS complement(2399240..2399995) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" /label="zinT CDS" gene complement(2399240..2399995) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /label="zinT gene" promotor_-10 complement(2400026..2400045) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2400042) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2400061..2400066) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2400127..2400657) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2400127..2400657) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2400703..2400722) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2400726) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2400736..2400743) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2400792..2401772 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2400792..2401772 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2402046..2403362) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2402046..2403362) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2403363..2403476) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2403477..2404346) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2403477..2404346) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2404369..2404388) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404386) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2404403..2404408) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2404453..2404454) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404461) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2404491..2404492) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2404491..2405594 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2404491..2405594 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2405484..2405503 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2405490 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2405841) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2405867..2406700) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2405867..2406700) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2406730..2406749) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2406739) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2406905..2406909 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2406920..2407142 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2406920 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2406924..2406943 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2407143..2407406 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2407143..2407406 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2407394 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2407543..2408358 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2407543..2408358 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2408693..2408765) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2408736) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2408766..2409122) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2408766..2409122) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2409175..2409534) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2409175..2409534) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2409627..2409646) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2409637) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2409806..2409907) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2409806..2409907) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2409947..2410049) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2409989) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2410050..2410436) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2410050..2410436) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2410478..2410494) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2410494) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2410627..2410633 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2410648..2410659 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2410648 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2410685..2410930 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2410685..2410930 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2410948..2411316 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2410948..2411316 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2411335..2412471 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2411335..2412471 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2412490..2412687 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2412490..2412687 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2412703..2413002 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2412703..2413002 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2412993 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2413265..2413687) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2413265..2413687) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2413685..2413688 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2413704..2413723 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2413719..2413869 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2413719 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2413722..2413741) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2413729) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2413755..2413762) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2413838..2413857) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2413846) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2413870..2414064 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2413870..2414064 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2413872..2413879) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2414082..2414089 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2414105..2414124 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2414109 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2414110..2414194 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2414195..2415244 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2414195..2415244 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2415312..2415319 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415334..2415353 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415347 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2415375..2415884 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2415375..2415884 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2415853 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2415898..2417003 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2415926..2417959) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2415926..2417959) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2415951) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2417868..2418035) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2417868..2418035) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2417960..2418115) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2418116..2418943) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2418116..2418943) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2418964..2419773) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2418964..2419773) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2419790..2420278) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2419790..2420278) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2420278..2420718) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2420278..2420718) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2420715 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2420755..2420773) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2420759) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2420908..2423715) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2420908..2423715) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2423931..2423950) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2423937) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2424262..2424402 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2424262..2424402 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2424383..2424402 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2424393 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2424441..2425829 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2424441..2425829 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2425818 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2425851..2425924) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2425893) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2425925..2426557) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2425925..2426557) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2425981) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2426611..2426630) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426622) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2426636..2426642 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2426645..2426652) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2426656..2426675 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2426661 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2426710..2427537 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2426710..2427537 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2427533 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2427650..2427659 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2427672..2427687 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2427677 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2427733..2428233 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2427733..2428233 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2428233..2429090 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2428233..2429090 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2429108..2429119) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2429127) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2429134..2429140) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2429201..2431105 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2429201..2431105 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2431186..2431192 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2431208..2431226 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2431214 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2431239..2431529 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2431239..2431529 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2431530..2431645 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2431627..2431634 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2431647..2431772 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2431647 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2431648..2431666 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2431666..2431766 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2431666..2431766 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2431729 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2431773..2434937) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2431773..2434937) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2431789) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2432923..2432932 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2432946..2432965 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2432967 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2434953..2435537) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2434953..2435537) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2435760..2436302) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2435760..2436302) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2436303..2436388) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2436386..2436401) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436388) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2436414..2436423) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2436457..2436673) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2436491..2436649) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2436491..2436649) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2436500) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2436671..2436690) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436673) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2436675..2436805) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2436704..2436713) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2436806..2436955) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2436806..2436955) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2436949 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2436956..2437046) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2437048..2437267) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2437091) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2437213 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2437246..2437265) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2437267) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2437269..2437344) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2437280..2437287) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2437345..2438145) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2437345..2438145) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2438214..2438367) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2438257) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2438358..2438377) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2438367) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2438392..2438398) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2438408..2438776) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2438408..2438776) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2438777..2438873) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2438859..2438878) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2438863..2438866 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2438879) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2438882..2438901 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2438884 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2438885..2439091 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2438894..2438898) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2439092..2442034 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2439092..2442034 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2442053..2442535 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2442053..2442535 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2442515 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2442571..2442801) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2442571..2442801) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2442591) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2442802..2442883) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2442884..2444023) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2442884..2444023) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2444025..2444948) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2444025..2444948) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2444941) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2444949..2445012) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2445013..2445708) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2445013..2445708) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2445448..2445467) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2445466) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2445480..2445489) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2445729..2446370) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2445729..2446370) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2445937..2445956) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2445956) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2445973..2445976) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2446422..2446431 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2446428..2446447) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2446434) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2446444..2446463 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2446453..2446517 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2446453 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2446463..2446466) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2446498..2446505 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2446519 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2446521..2446538 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2446563..2446766 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2446563..2446766 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2446773 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2446803..2447504) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2446803..2447504) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2446815) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2447569..2449323) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2447569..2449323) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2447597..2447616) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2447607) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2448638..2448653) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448641) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2448666..2448675) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2448869..2448887) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448883) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2448902..2448909 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2448902..2448907) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2448924..2448943 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2448929 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2449377..2449850) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2449377..2449850) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2449384) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2449851..2449983) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2449965..2449984) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449983) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2449985..2450093) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2449998..2450005) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2450086..2450105) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450093) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2450101..2450736) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2450101..2450736) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2450121..2450125) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2450231..2450236 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2450252..2450270 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2450259 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2450743..2452011) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2450743..2452011) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2452030..2452959) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2452030..2452959) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2452965..2453618) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2452965..2453618) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2453619..2453723) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2453705..2453724) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453723) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2453740..2453744) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2453770..2454852) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2453770..2454852) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2453804) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2454868..2454887) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2454888) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2454902..2454905) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2454978) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2454983..2455264) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2454983..2455264) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2455043) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2455282..2455698) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2455282..2455698) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2455530..2455548) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2455549) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2455564..2455569) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2455706..2455972) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2455706..2455972) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2455860..2455868 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2455883..2455902 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2455891..2457080 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2455891 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2455973..2456033) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2456027..2456046) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456033) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2456057..2458693) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2456057..2458693) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2456060..2456067) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2458459..2458477) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2458475) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2458491..2458498) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2458694..2458772) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2458773..2458980) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2458773..2458980) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2458988..2459007) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2459003) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2459022..2459029) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2459024..2460085) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2459024..2460085) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2459994..2459999 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2460005..2460240 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2460006 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2460015..2460033 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2460102..2460113) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460103) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2460127..2460133) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2460241..2460969 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2460241..2460969 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2460697) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2460991..2461812 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2460991..2461812 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2461873..2462523 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2461873..2462523 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2462540..2463196 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2462540..2463196 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2463195 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2463231..2463362) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2463231..2463362) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2463249) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2463384..2463575) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2463384..2463575) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2463587..2464111) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2463587..2464111) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2463698) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2463702..2463713) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2463728..2463734) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2464082..2464093) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2464088) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2464108..2464114) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2464169..2466565) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2464169..2466565) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2464195) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2464415..2464421 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2464429 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2464436..2464447 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2464449..2464798 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2464550) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2466590..2467210) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2466590..2467210) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2467296..2468411) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2467296..2468411) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2467297) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2468442..2469581) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2468442..2469581) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2469148..2469167) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469160) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2469181..2469188) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469600..2470016) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2469600..2470016) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2470017..2470114) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2470099..2470118) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2470114) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2470134..2470137) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2470162..2470169 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2470183..2470202 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2470191 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2470219..2471484 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2470219..2471484 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2471483 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2471526..2472290) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2471526..2472290) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2471544) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2472374..2472574) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2472374..2472574) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2472392) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2472561 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2472562..2472571 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2472572..2472591) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472583) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472604..2472611) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472626..2474404) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2472626..2474404) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2474418..2475692) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2474418..2475692) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2475782..2476014) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2475782..2476014) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2475812) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2476024..2476027 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2476038..2476057) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2476042..2476061 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2476044..2476328 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2476044 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2476057) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2476072..2476079) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2476074..2476244) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2476074..2476244) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2476275..2476286) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2476292) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2476301..2476307) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2476304..2476311 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2476325..2476343 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2476330 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2476377..2477933 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2476377..2477933 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2477912 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2477960..2478358) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2477960..2478358) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2477968) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2478412..2480616) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2478412..2480616) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2480645..2480664) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480652) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2480654..2480744) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2480679..2480686) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2480708 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2480784..2481296) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2480784..2481296) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2480789) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2481302..2483662) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2481302..2483662) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2481766..2481785) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2481774) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2481799..2481808) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2483676..2483695) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483687) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2483710..2483716) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2483729..2484052) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2483729..2484052) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2484073..2484091) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2484084) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2484106..2484112) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2484128..2484625) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2484128..2484625) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2484626..2484701) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2484695..2484714) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2484701) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2484728..2484735) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2484783..2486996) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2484783..2486996) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2484788) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2486555..2486560 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2486574..2486593 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2486582 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2487035..2487331) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2487035..2487331) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2487242 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2487332..2487410) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2487372..2487377 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2487394..2487412 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2487396..2487415) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2487396 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2487410) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2487412..2488330) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2487430..2487433) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2487447..2489003 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2487447..2489003 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2488316..2488334) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2488330) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2488346..2488354) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2489004..2489768 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2489007..2489663) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2489007..2489663) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2489682..2489693) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489694) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2489707..2489713) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2489746..2489751 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2489767..2489785 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2489770 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2489798..2490250 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2489798..2490250 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2490234 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2490289) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2490307..2490573) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2490307..2490573) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2490610..2491755) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2490610..2491755) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2490662) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2490706) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2490708..2490727) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2490742..2490747) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2491782..2492810) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2491782..2492810) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2492840..2493040) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2492840..2493040) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2493033..2494037) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2493033..2494037) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2494048..2494653) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2494048..2494653) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2494672..2494691) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494688) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2494690..2494791) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2494702..2494708) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2494792..2495304) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2494792..2495304) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2495333..2495344) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2495348) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2495352..2496659) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2495352..2496659) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2495359..2495365) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2496613) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2496683..2496701) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2496698) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2496716..2496722) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2496730..2497755) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2496730..2497755) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2497792..2497811) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2497812) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2497826..2497833) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2497881..2497888 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2497902..2497921 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2497910 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2497942..2497947 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2497956 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2497963..2497981 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2497993..2498640 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2497993..2498640 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2498315..2498648) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2498619 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2498650..2498847) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2498686..2498808) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2498686..2498808) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2498693) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2498856) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2498857..2498874) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2498881..2498888) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2498893..2499183 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2498893..2499183 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2498904..2498923 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2498904..2499051 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2498904 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2499190..2499330 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2499190..2499330 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2499319 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2499379..2499385 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2499393..2499493 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2499400..2499418 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2499401 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2499453 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2499494..2500948 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2499494..2500948 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2500949 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2500989..2501711) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2500989..2501711) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2500994..2501415 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2501005) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2501734..2501753) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2501751) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2501767..2501774) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2501814..2502410) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2501814..2502410) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2501829) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2502453..2502464) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2502455) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2502457..2502521) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2502479..2502485) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2502558..2503721) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2502558..2503721) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2502566) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2503722..2503797) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2503773..2503791) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2503797) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2503807..2503812) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2503838..2504944) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2503838..2504944) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2504520..2504538) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2504545) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2504554..2504559) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2504856 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2504857..2504860 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2504931..2505800) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2504931..2505800) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2505025 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2505754..2507349) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2505754..2507349) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2507377..2507384 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2507377..2507396) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2507398 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2507400..2507419 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507401) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2507411..2507418) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2507452..2508639 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2507452..2508639 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2507453..2507472) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507471) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2507487..2507496) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2508354..2508359 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2508368 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2508370..2508389 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2508599..2509141 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2508599..2509141 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2509124 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2509166..2510023) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2509166..2510023) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2509169..2509878 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2509186) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2510040..2510483) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2510040..2510483) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2510544..2511830) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2510544..2511830) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2511864..2512442) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2511864..2512442) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2512443..2512508) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2512493..2512512) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2512508) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2512510..2512727) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2512520..2512642 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2512520..2512642 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2512526..2512533) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2512763..2513047) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2512763..2513047) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2512772) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2513060..2513398) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2513060..2513398) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2513401..2513709) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2513401..2513709) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2513723..2513798) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2513723..2513798) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2513810..2513829) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513830) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2513843..2513850) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2513856..2514722) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2513856..2514722) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2514715..2515509) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2514715..2515509) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2515512 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2515518..2515618 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2515533..2515551) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2515544) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2515567..2515572) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2515578 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2515621 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2515656) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2515659..2516465) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2515659..2516465) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2516467..2517147) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2516467..2517147) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2517200..2517718) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2517200..2517718) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2517715..2518587) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2517715..2518587) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2518618..2519631) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2518618..2519631) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2519672) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2519684..2519702) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2519723..2520418) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2519723..2520418) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2520455..2521024) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2520455..2521024) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2520876..2520891) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2520885) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2520904..2520913) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2521063..2521082) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2521079) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2521096..2521102) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2521175) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2521177..2522175) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2521177..2522175) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2522222..2522241) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522230) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2522253..2522260) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2522298) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2522309..2523055) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2522309..2523055) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2523083..2523102) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2523090) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2523117..2523124) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2523195..2524487) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2523195..2524487) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2523200) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2524488..2524546) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2524547..2527189) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2524547..2527189) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2527190..2527248) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2527249..2527471) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2527249..2527471) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2527292) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2527500..2527519) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2527512) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2527514..2527622) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2527534..2527539) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2527576..2527585 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2527598..2527617 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2527599 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2527615..2527629) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2527622) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2527637..2527641) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2527637..2527828 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2527637..2527828 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2527847..2528872) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2527847..2528872) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2527877) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2528905..2530632) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2528905..2530632) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2530234..2530237 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2530253..2530272 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2530259 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2530628..2530632 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2530641..2530655 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2530655 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2530670..2530688) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2530686) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2530704..2530709) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2530763..2532055) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2530763..2532055) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2530780) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2532085..2533059) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2532085..2533059) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2533056..2533844) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2533056..2533844) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2533834..2534778) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2533834..2534778) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2534811..2535641) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2534811..2535641) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2535649..2537016) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2535649..2537016) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2537080..2537099) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2537086) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2537088..2537177) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2537137..2537156 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2537145 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2537174..2537193) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537177) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2537179..2537595) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2537204..2537212) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2537246..2537743 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2537246..2537743 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2537579..2537597) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537595) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2537597..2537727) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2537613..2537619) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2537707..2537718) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2537727) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2537733..2537739) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2537765..2538352) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2537765..2538352) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2537793) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2538349..2540673) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2538349..2540673) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2540674..2540785) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2540770..2540789) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2540785) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2540803..2540810) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2540854..2542512) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2540854..2542512) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2540873) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2542556..2542574) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2542567) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2542590..2542595) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2542664..2543926) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2542664..2543926) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2542674) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2543927..2544016) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2544004..2544023) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2544016) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2544018..2544149) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2544035..2544042) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2544194) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2544198..2545472) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2544198..2545472) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2545473..2545662) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2545649..2545668) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545662) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2545683..2545687) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2545700..2546704) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2545700..2546704) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2546729..2546748) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2546747) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2546760..2546767) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2546823..2547422) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2546823..2547422) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2546844) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2547435..2548853) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2547435..2548853) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2548742..2548746 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2548761..2548765 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2548761 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2548903..2550000) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2548903..2550000) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2550021..2551577) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2550021..2551577) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2550417..2550420 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2550433..2552874 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2550433 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2550435..2550454 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2551564..2552592) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2551564..2552592) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2552616..2553134) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2552616..2553134) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2552855..2552858 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2552874..2552878 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2552876 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2553131..2554855) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2553131..2554855) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2554856..2554976) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2554977..2555223) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2554977..2555223) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2555020) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2555224..2555350) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2555332..2555351) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2555350) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2555352..2555482) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2555366..2555373) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2555477..2555496) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2555486) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2555510..2555513) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2555608..2555617 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2555631..2555650 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2555633 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2555671..2556006 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2555671..2556006 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2556000 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2556087..2556094 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2556108..2556127 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2556110..2556174 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2556110 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2556175..2556630 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2556175..2556630 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2556738..2556744 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2556758..2556776 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2556765 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2556814..2557635 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2556814..2557635 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2557628 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2557692 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2557699..2557772) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2557699..2557772) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2557733) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2557809..2557828) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557812) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2557842..2557849) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2557903..2558412) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2557903..2558412) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2557920) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2558428..2559024) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2558428..2559024) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2559037..2559774) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2559037..2559774) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2559856..2559875) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2559872) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2559885..2560985) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2559885..2560985) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2559890..2559895) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2559902) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2561008..2561026) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2561024) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2561041..2561046) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2561100..2561918) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2561100..2561918) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2561112) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2561926..2562366) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2561926..2562366) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2562409..2562428) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562418) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2562420..2562562) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2562444..2562448) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2562607) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2562610..2562834) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2562610..2562834) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2562883 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2562885..2562903 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2562892..2562911) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562912) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2562925..2562934) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2562950..2563393) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2562950..2563393) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2563454..2564215) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2563454..2564215) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2563462) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2564218..2565978) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2564218..2565978) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2566012..2566620) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2566012..2566620) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2566390..2566397 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2566410..2566429 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2566412 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2566621..2566716) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2566706..2566725) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2566716) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2566718..2567339) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2566740..2566747) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2566855..2566859 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2566869..2566969 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2566876..2566895 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2566885 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2566913..2567359 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2566913..2567359 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2566929 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2567347 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2567385) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2567403..2568629) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2567403..2567894) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2567403..2568629) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2567403..2567894) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2568743) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2568755..2568934) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2568755..2568934) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2568787) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2568959..2568978) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2568966) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2568991..2568998) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2568999..2570771) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2568999..2570771) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2570798..2570817) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2570812) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2570831..2570838) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2570901) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2570907..2571221) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2570907..2571221) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2571247..2571266) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2571261) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2571263..2571472) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2571282..2571284) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2571366..2571476) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2571366..2571476) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2571462..2571480) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2571472) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2571495..2571501) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2571544..2573031) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2571544..2573031) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2573032..2573144) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2573125..2573144) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2573144) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2573159..2573166) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2573248..2574225) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2573248..2574225) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2573256) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2574261..2575034) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2574261..2575034) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2575049..2575825) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2575049..2575825) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2575114 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2575840..2576424) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2575840..2576424) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2576466..2576485) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2576466) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2576498..2576505) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2576529..2578211) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2576529..2578211) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2578240..2578259) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2578248) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2578336) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2578400..2578804) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2578400..2578804) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2578402) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2578819..2581176) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2578819..2581176) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2581197..2582909) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2581197..2582909) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2582910..2582982) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2582983..2583516) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2582983..2583516) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2583523..2583780) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2583523..2583780) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2583807..2583826) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583823) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2583838..2583845) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2583863..2583882 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2583870 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2583914..2584855 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2583914..2584855 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2584587..2584606) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2584602) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2584620..2584627) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2584838 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2584870) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2584891..2587305) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2584891..2587305) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2584914) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2587321..2588355) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2587321..2588355) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2588356..2588676) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2588437..2588643 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2588437..2588643 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2588666..2588930 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2588666 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2588671..2588690) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2588673..2588687 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2588676) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2588705..2588708) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2588710..2589456) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2588710..2589456) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2589483..2589502) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2589489..2589495 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2589496) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2589509..2589520 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2589516..2589522) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2589523 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2589575..2589790 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2589575..2589790 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2589772..2591184) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2589801..2589808 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2589824..2589843 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2589832 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2589859..2590965 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2589859..2590965 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2591001..2591004 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2591020..2591039 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2591024 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2591068..2592480 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2591068..2592480 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2591170..2591189) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2591184) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591202..2591211) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2592477..2593811 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2592477..2593811 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2593510,2593512) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2593809 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2593848) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2593850..2594092) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2593850..2594092) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2594093..2594264) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2594152..2594322) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2594152..2594322) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2594265..2596061) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2594265..2596061) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2594367..2594385) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2594385) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2594397..2594405) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2596058 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2596086..2596105) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2596096) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2596120..2596126) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2596156..2596212) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2596180) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2596213..2597715) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2596213..2597715) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2597586) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2597690..2597790) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2597730) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2597734..2598579) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2597734..2598579) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2598580..2599521) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2598580..2599521) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2599557..2600858) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2599557..2600858) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2600889..2602073) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2600889..2602073) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2602070..2602888) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2602070..2602888) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2602866..2603555) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2602866..2603555) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2603572..2605254) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2603572..2605254) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2605268..2606758) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2605268..2606758) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2606851..2606870) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606858) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2606860..2606935) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2606885..2606892) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2606936..2607907) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2606936..2607907) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2607908..2608036) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2608021..2608040) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2608036) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2608055..2608058) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2608104..2609189) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2608104..2609189) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2608118) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2609215..2609234) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2609238) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2609249..2609256) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2609307..2609316 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2609322 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2609328..2609343 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2609373..2609765 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2609373..2609765 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2609736 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2609781..2610087 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2609781..2610050) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2609781..2610050) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2609797) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2609966) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2610044 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2610107..2610466) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2610107..2610466) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2610120) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2610498..2610698) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2610498..2610698) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2610711..2611232) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2610711..2611232) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2611294..2611433) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2611294..2611433) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2611430..2611449) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611440) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2611442..2611506) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2611463..2611470) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2611488..2611507) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611506) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2611523..2611527) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2611625..2611632 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2611646..2611664 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2611646 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2611678..2612343 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2611678..2612343 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2612321 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2612375..2613070) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2612375..2613070) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2612397) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2612441) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2613092..2613532) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2613092..2613532) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2613554..2613573) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2613573) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2613589..2613592) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2613666..2614391) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2613666..2614391) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2613695) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2614369..2616150) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2614369..2616150) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2616234..2616237 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2616246..2616265) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2616251) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2616252..2616271 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2616259 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2616317..2617099 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2616317..2617099 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2617083 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2617133) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2617140..2619071) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2617140..2619071) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2619115..2619362) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2619115..2619362) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2619118..2619127) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2619118) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2619173) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2619373..2619392) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2619386) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2619388..2619468) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2619408..2619412) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2619469..2620314) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2619469..2620314) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2620334..2620352) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620340) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2620368..2620373) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2620393..2621034) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2620393..2621034) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2621068..2622003) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2621068..2622003) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2622031..2623449) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2622031..2623449) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2623478..2623497) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2623486) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2623512..2623515) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2623564..2624022) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2623564..2624022) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2623583) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2624023..2624170) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2624161..2624180) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2624170) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2624172..2624250) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2624195..2624198) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2624295) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2624296..2624676) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2624296..2624676) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2624677..2624831) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2624811..2624830) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2624818 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2624819..2624838 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2624831) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2624845..2624851) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2624909..2624920) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2624915..2625937) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2624915..2625937) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2624916) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2624935..2624941) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2625981..2626000) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2626012) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2626013..2626020) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2626143..2626523) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2626143..2626523) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2626167) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2626524..2626654) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2626579..2626583 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626599..2626618 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2626600..2626706 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2626600 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2626644..2626663) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2626654) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2626678..2626685) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2626707..2627897 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2626707..2627897 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2627529..2627547) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2627545) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2627563..2627568) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2627921..2628763 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2627921..2628763 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2628536..2628541 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2628557..2628575 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2628558 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2628756 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2628796) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2628805..2629398) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2628805..2629398) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2629414..2630046) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2629414..2630046) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2630047..2630211) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2630212..2631042) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2630212..2631042) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2631065..2633707) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2631065..2633707) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2633762..2633781) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2633771) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2633795..2633802) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2633831..2633950) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2633874) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2633951..2635690) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2633951..2635690) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2635683..2636405) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2635683..2636405) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2636473..2636492) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636483) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2636485..2636585) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2636506..2636512) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2636617..2637555) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2636617..2637555) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2636630) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2637599..2638870) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2637599..2638870) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2638655..2638674) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2638667) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2638871..2638953) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2638953) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2638955..2639033) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2638955..2638974) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2638990..2638994) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2639034..2640152) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2639034..2640152) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2639647 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2639994..2639997 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2640002 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2640131 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2640153..2640359) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2640327..2640339 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2640338 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2640345..2640364) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640359) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2640379..2640383) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2640479) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2640486..2640950) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2640486..2640950) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2640963..2640982) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640977) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640979..2642164) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2640979..2640984 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2640995..2641003) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2640999..2641017 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2641005 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2641047..2642162 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2641047..2642162 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2642133 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2642195..2642578) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2642195..2642578) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2642209) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2642579..2642670) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2642671..2644428) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2642671..2644428) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2644471..2645430) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2644471..2645430) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2645431..2645532) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2645521..2645540) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2645532) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2645556..2645560) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2645614..2646591) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2645614..2646591) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2645641) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2646576..2647448) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2646576..2647448) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2647410..2647415 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2647431..2647449 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2647435..2648609 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2647435 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2647449..2647532) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2647521..2647540) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647532) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2647534..2647686) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2647556..2647560) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2647688..2647782) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2647731) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2647783..2649015) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2647783..2649015) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2649016..2649132) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2649120..2649139) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2649132) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2649152..2652499) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2649152..2652499) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2649153..2649160) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2650164..2650173 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2650185..2650200 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2650185 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2650373..2650392) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650392) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2650406..2650413) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2652530..2652549) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2652548) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2652563..2652570) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2652588..2652593 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2652605 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2652609..2652627 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2652639..2652980 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2652639..2652980 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2652977..2653480 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2652977..2653480 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2653513..2653516 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2653531..2653550 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2653531 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2653582..2653773 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2653582..2653773 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2653583) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2653749 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2653791..2654732) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2653791..2654732) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2653794..2654165 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2653826) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2654134..2654143 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2654157..2654176 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2654167..2654561 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2654167 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2654523..2654529 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2654545..2654564 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2654563..2654862 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2654563 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2654751..2654770) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654767) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2654769..2655183) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2654785..2654788) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2654863..2655165 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2654863..2655165 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2655166..2656961 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2655184..2656503) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2655184..2656503) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2656529..2656548) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2656550) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2656563..2656568) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2656679..2657581) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2656679..2657581) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2657600..2658850) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2657600..2658850) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2658868..2659560) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2658868..2659560) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2659607..2660935) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2659607..2660935) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2660932..2661213) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2660932..2661213) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2661228..2662232) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2661228..2662232) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2662229..2663008) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2662229..2663008) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2663005..2663712) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2663005..2663712) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2663742..2664461) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2663742..2664461) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2664287..2664294 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2664309..2664328 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664309 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2664483..2665295) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2664483..2665295) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2665309..2666118) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2665309..2666118) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2666132..2666668) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2666132..2666668) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2666705..2666712 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2666723..2666742) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2666726..2666745 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2666729..2666820 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2666729 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2666739) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2666756..2666763) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2666821..2667747 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2666821..2667747 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2667223..2667752) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2667797) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2667798..2668481) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2667798..2668481) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2668482..2668543) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2668544..2669311) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2668544..2669311) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2669356..2669375) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2669378) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2669391..2669393) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2669438..2669674) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2669438..2669674) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2669523 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2669543) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2669634..2671019) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2669634..2671019) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2671016..2672227) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2671016..2672227) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2672228..2672305) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2672298..2672317) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2672304) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2672332..2672339) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2672397..2672909) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2672397..2672909) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2672415) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2672935..2672954) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2672943) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2672968..2672975) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2672994..2674181) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2672994..2674181) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2673009) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2674182..2674286) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2674271..2674290) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2674286) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2674288..2674417) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2674306..2674310) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2674354..2674557) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2674354..2674557) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2674415..2674426) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2674417) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2674441..2674447) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2674529..2675518) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2674529..2675518) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2674547) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2675579..2676082) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2675579..2676082) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2675585) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2675799..2675899 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2675859 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2676078 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2676105..2676124) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2676121) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2676138..2676145) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2676192..2676647) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2676192..2676647) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2676220) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2676661..2677341) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2676661..2677341) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2676753) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2676760..2676771) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2676786..2676792) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2677079) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2677354..2677372) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2677368) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2677387..2677392) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2677416..2677910) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2677416..2677910) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2677431) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2677923..2678930) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2677923..2678930) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2678954..2678969) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678971) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2678973..2679052) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2678981..2678990) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2679030..2679049 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2679040 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2679045..2679064) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2679049..2679115 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2679052) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2679080..2679084) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2679116..2679919 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2679116..2679919 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2679849 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2679907 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2679951..2681540) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2679951..2681540) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2679960) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2681560..2683149) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2681560..2683149) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2683195..2683212) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683200) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683228..2683234) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2683327) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2683328..2683537) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2683328..2683537) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2683533..2683537 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2683537 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2683546..2683560 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2683558..2683569) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683569) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683584..2683590) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2683631..2684836) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2683631..2684836) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2684840..2685985) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2684840..2685985) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2685986..2687129) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2686072..2686079 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2686090..2686179 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2686090 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2686092..2686111 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2686180..2687517 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2686180..2687517 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2687115..2687134) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2687129) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2687149..2687156) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2687493 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2687612..2689300) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2687612..2689300) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2687613) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2689301..2689406) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2689383..2689391 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2689394..2689413) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2689402..2689421 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2689406) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2689406 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2689407..2689496 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2689408..2689967) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2689429..2689431) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2689497..2690303 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2689497..2690303 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2689971..2689990) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2689984) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690002..2690009) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2690253..2690299) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2690275) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2690300..2690923) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2690300..2690923) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2690304..2690646 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2690624..2690631 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2690646..2690665 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2690648..2690791 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2690648 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2690763..2690767 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2690783..2690802 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2690793..2690923 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2690793 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2690925..2691049 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2690925 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2690939..2690957) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2690941..2690960 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2690957) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690968..2690976) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2691050..2691541 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2691050..2691541 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2691520 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2691579..2693318) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2691579..2693318) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2691597) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2692792..2692799 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2692813..2692831 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2692816 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2692818..2693413 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2693348..2693367) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2693356) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2693358..2694191) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2693394..2693401 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2693415..2693612 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2693415..2693434 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2693415 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2693472..2693604 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2693472..2693604 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2693613..2694215 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2693613..2694215 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2694138 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2694193..2694412) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2694201 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2694236) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2694248 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2694293..2694466 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2694408..2694426) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2694420) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2694424 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2694441..2694447) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2694486..2695754) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2694486..2695754) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2694512) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2695778..2696051) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2695778..2696051) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2695799..2695942) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2695842) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2696049..2696068) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696061) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2696081..2696088) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2696096..2697814) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2696096..2697814) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2697828..2697835 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2697842..2697861) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2697850..2697869 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2697856 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2697865) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2697875..2697881) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2697898..2697905 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2697919..2697938 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2697922 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2697975..2698607 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2697975..2698607 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2698180..2698188 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2698202..2698221 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2698208 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2698634..2699278 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2698634..2699278 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2699275..2700438 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2699275..2700438 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2700429 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2700449..2701177) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2700449..2701177) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2700485) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2701167..2701985) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2701167..2701985) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2702048..2703052) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2702048..2703052) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2702065) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2703087..2703106) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2703102) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2703104..2703212) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2703212..2703231) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2703212) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2703214..2703279) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2703245..2703251) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2703325) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2703328..2704404) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2703328..2704404) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2704445..2704464) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2704465) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2704467..2704567) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2704479..2704486) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2704501 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2704555..2704574) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2704567) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2704588..2704594) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2704640..2704966) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2704640..2704966) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2704649) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2704990..2705445) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2704990..2705445) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2705476..2705898) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2705476..2705898) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2705919..2705937) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2705932) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2705951..2705957) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2705971..2705989) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2705980) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2706000..2706008) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2706060..2707358) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2706060..2707358) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2706069) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2707383..2707402) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707384) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2707386..2707582) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2707415..2707424) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2707565..2707584) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707582) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2707596..2707602) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2707608..2710466) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2707608..2710466) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2710500..2710519) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2710510) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2710535..2710539) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2710609) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2710626..2711231) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2710626..2711231) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2711247..2712056) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2711247..2712056) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2712071..2712394) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2712071..2712394) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2712395..2712533) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2712433..2712549) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2712433..2712549) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2712520..2712539) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2712533) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2712541..2712548 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2712563..2712582 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2712568 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2712629..2713075 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2712629..2713075 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2713076..2713804 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2713130..2714203) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2713130..2714203) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2713149) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2714225..2714244) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2714229) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2714258..2714265) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2714300..2714303 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2714318..2714337 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2714323 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2714362..2714679 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2714362..2714679 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2714679 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2714732..2716432) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2714732..2716432) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2714751) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2716464..2716482) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2716471) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2716497..2716503) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2716514..2717284) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2716514..2717284) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2717285..2717373) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2717371..2717390) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717373) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717406..2717410) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2717430..2718071) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2717430..2718071) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2717440) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2717505) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2718097..2718116) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718106) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2718108..2718556) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2718132..2718136) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2718215..2718221 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2718236..2718247 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2718243 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2718278..2718556 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2718278..2718556 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2718557..2718727 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2718557..2719171) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2718557..2719171) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2718705 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2719172..2719507) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2719499..2719518) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2719507) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2719533..2719540) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2719534..2721690) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2719534..2721690) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2721231,2721233) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2721716..2722645) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2721716..2722645) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2722694..2723608) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2722694..2723608) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2723371..2723389) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2723379) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2723403..2723409) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2723634..2724185) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2723634..2724185) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2724048..2724067 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2724051 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2724208..2724227) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2724220) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2724243..2724246) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2724268..2724275 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2724286..2724305 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2724289..2724300) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2724293 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2724303) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2724314..2724320) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2724334..2725269 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2724334..2725269 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2725245 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2725303..2726694) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2725303..2726694) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2725315) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2726695..2727135) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2726721..2726726 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2726740..2726759 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2726753 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2726791..2728089 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2726791..2728089 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2727112..2727131) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727135) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727146..2727152) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2728076 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2728129..2729286) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2728129..2729286) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2728154) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2728402..2728407 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2728422..2728440 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2728430 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2729283..2729993) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2729283..2729993) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2730007..2730022) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730024) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2730034..2730043) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2730050..2730051 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2730063..2730168 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2730063 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2730071..2730081 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2730134..2730140 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2730155..2730174 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2730170..2730283 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2730170 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2730284..2730505 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2730284..2730505 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2730488 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2730557 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2730626..2731345) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2730626..2731345) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2730640) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2731411) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2731414..2733048) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2731414..2733048) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2733080..2733099) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2733096) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2733166..2733170 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2733186..2733205 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2733204 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2733250..2734512 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2733250..2734512 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2734513..2734611 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2734585..2734591 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2734607..2734625 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2734613..2734700 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2734613 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2734701..2736239 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2734701..2736239 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2736219 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2736276..2736458) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2736276..2736458) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2736295) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2736473..2736491) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736493) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2736507..2736512) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2736526..2737194) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2736526..2737194) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2737216..2738502) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2737216..2738502) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2738514..2739017) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2738514..2739017) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2739014..2740135) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2739014..2740135) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2740143..2741108) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2740143..2741108) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2741134) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2741135..2741154) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2741169..2741176) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2741264..2741271 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2741284 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2741287..2741306 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2741324..2743642 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2741324..2743642 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2743632 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2743683..2745179) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2743683..2745179) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2743685) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2745204..2746064) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2745204..2746064) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2746140..2746159) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2746149) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2746175..2746182) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2746271..2747032) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2746271..2747032) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2746300) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2747033..2747108) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2747109..2748296) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2747109..2748296) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2748365..2749372) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2748365..2749372) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2749375..2750070) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2749375..2750070) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2750067..2751236) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2750067..2751236) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2750103..2750110 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2750125..2750144 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750143 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2751226..2752572) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2751226..2752572) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2751642..2751646 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2751661 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2751662..2751680 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2752562..2753338) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2752562..2753338) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2753339..2753431) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2753417..2753436) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753431) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2753451..2753458) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2753548..2754447) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2753548..2754447) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2754470..2754488) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2754487) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2754499..2754507) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2754577..2754584 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2754600..2754619 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2754606 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2754665..2755699 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2754665..2755699 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2755648..2755655 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2755670..2755678 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2755687 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2755733..2757013 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2755733..2757013 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2757006..2757917 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2757006..2757917 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2757914..2758744 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2757914..2758744 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2758717..2758721 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2758737..2758756 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2758745 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2758764..2760062 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2758764..2760062 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2760043 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2760084..2760395) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2760084..2760395) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2760095) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2760419..2760438) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760427) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2760453..2760460) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2760461 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2760512..2762926) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2760512..2762926) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2760516) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2762927..2763022) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2763036..2763250) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2763036..2763250) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2763067) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2763262..2763281) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2763283) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2763287..2763292 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2763296..2763301) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2763308..2763326 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2763321..2763761 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2763321 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2763353..2763688) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2763353..2763688) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2763683..2763947) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2763932..2763951) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2763947) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2763966..2763973) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2763986..2763993 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2764007..2764026 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2764023 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2764025..2764092 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2764093..2764878 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2764093..2764878 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2764879..2764935 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2765115..2766308) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2765115..2766308) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2765135) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2766309..2766407) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2766388..2766407) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766407) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2766421..2766428) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2766445..2766448 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2766463..2766482 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2766467 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2766497..2767243 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2766497..2767243 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2767138 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2767237 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2767280..2769220) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2767280..2769220) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2767291) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2769210..2769971) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2769210..2769971) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2769995..2770013) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2770014) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2770073..2771077) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2770073..2771077) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2770112) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2771070..2771765) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2771070..2771765) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2771789..2771807) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771801) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2771823..2771826) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2771862..2773172) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2771862..2773172) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2771884) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2773162..2773857) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2773162..2773857) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2773872..2774849) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2773872..2774849) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2774879..2775865) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2774879..2775865) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2775735..2775744 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2775751 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2775757..2775772 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2775859..2776737) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2775859..2776737) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2776730..2777122) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2776730..2777122) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2777123..2777367) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2777156..2777293) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2777156..2777293) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2777291 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2777362..2777381) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2777367) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2777395..2777402) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2777448..2777720) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2777448..2777720) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2777455) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2777760..2777771) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2777764..2777772 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2777764) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2777775 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2777786..2777792) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2777786..2777804 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2777815..2777820 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2777834..2777853 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2777841 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2777882..2778850 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2777882..2778850 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2778847..2779431 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2778847..2779431 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2779395 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2779421..2780524) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" /label="tbcS CDS" gene complement(2779421..2780524) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /label="tbcS gene" downshifts complement(2779462) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2780545..2781324) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" /label="ytpA CDS" gene complement(2780545..2781324) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /label="ytpA gene" promotor_-35 2780967..2780974 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2780989..2781008 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2781006 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2781325..2781904) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2781373..2781888 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" /label="ytoA CDS" gene 2781373..2781888 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /label="ytoA gene" promotor_-10 complement(2781895..2781914) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781904) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2781906..2782040) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2781926..2781933) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2782015..2782034) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2782040) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2782133..2783524) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2782133..2783524) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2782141) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2783525..2783659) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2783660..2785558) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2783660..2785558) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2784716..2784722 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2784737..2784748 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2784749 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2785559..2785682) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2785708..2786910) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2785708..2786910) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2785727) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2786953..2786964) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2786959) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2786961..2787077) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2786978..2786984) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2787078..2787216) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2787078..2787216) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2787176 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2787225..2787244) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2787240) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2787261..2787265) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2787337..2787344 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2787356 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2787358..2787377 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2787413..2788996 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2787413..2788996 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2788985 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2789035..2789277) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2789035..2789277) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2789049) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2789329..2790102) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2789329..2790102) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2790103..2790193) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2790169..2790178 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2790182..2790201) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2790190 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2790191..2790210 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2790195) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2790216..2790223) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2790253..2791257 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2790253..2791257 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2791270..2792052 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2791270..2792052 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2791274..2792822) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2792027..2792839 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2792027..2792839 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2792824 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2792866..2793342) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2792866..2793342) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2792867) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2793372..2793391) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2793385) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2793387..2793521) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2793521) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2793523..2793534) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2793549..2793555) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2793551..2793955) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2793551..2793955) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2793983..2794002) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794000) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2794002..2794088) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2794015..2794024) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2794121..2794558) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2794121..2794558) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2794133) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2794575..2794593) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794593) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2794595..2794820) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2794608..2794614) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2794650..2794669 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2794651..2794827 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2794651..2794827 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2794652 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2794821..2795258) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2794821..2795258) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2794847 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2795277..2795296) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2795298) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2795307..2795315) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2795378..2795851) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2795378..2795851) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2795387) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2795474) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2795852..2796203) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2795923..2795930 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2795943..2795962 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2795948 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2795980..2796207 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2795980..2796207 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2796204..2796767) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2796204..2796767) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2796792..2796811) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2796807) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2796861..2797109) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2796861..2797109) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2796882) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2797137..2797156) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2797170..2797177) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2797174) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2797236..2797242 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2797256..2797267 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2797268 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2797314..2798645 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2797314..2798645 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2798689..2799729 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2798689..2799729 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2799723..2799729 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2799744..2799755 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2799754 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2799783..2799941 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2799783..2799941 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2799930 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2799960..2800847) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2799960..2800847) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2799983) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2800837..2802144) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2800837..2802144) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2802150..2802902) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2802150..2802902) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2802921..2803841) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2802921..2803841) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2803877..2803888) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2803878) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2803880..2803971) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2803902..2803908) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2803956 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2803957..2803976) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2803959..2803971 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2803971) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2803973..2804054) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2803991..2803998) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2804054) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2804063..2804082) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2804096..2804103) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2804121..2805236) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2804121..2805236) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2804164) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2805233..2806693) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2805233..2806693) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2806136..2806154) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2806140) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2806169..2806175) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2806782) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2806784..2807599) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2806784..2807599) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2807634..2808458) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2807634..2808458) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2807716..2807735) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807716) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807751..2807754) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2807882) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2807892..2807903) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2807918..2807924) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2808446..2810188) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2808446..2810188) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2810185..2811600) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2810185..2811600) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2811601..2811713) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2811693..2811712) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2811713) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2811715..2811865) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2811728..2811731) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2811826..2811832 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2811846..2811865) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2811846..2811857 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2811854 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2811865) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2811879..2811888) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2811890..2812609 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2811890..2812609 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2811960..2812617) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2812598 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2812618..2813436) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2812618..2813436) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2813457..2813476) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2813471) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2813491..2813499) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2813537..2813545 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2813558..2813577 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2813559 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2813608..2814894 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2813608..2814894 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2814891..2815841 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2814891..2815841 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2815844..2817067 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2815844..2817067 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2816991) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2817068..2817635 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2817141..2817572) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2817141..2817572) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2817167) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2817574..2818629) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2817574..2818629) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2818644..2819777) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2818644..2819777) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2819810..2819829) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2819829) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2819842..2819851) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2819915..2819924 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2819938..2819957 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2819940 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2819967..2821040 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2819967..2821040 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2820264..2820270 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2820281 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2820284..2820295 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2821029 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2821067..2821073 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2821088 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2821089..2821107 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2821120..2821587 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2821120..2821587 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2821559 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2821618..2824014) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2821618..2824014) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2821633) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2824001..2825455) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2824001..2825455) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2825452..2826483) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2825452..2826483) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2826507..2827649) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2826507..2827649) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2827646..2829529) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2827646..2829529) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2828355..2829774 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2829561..2829576) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2829574) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2829591..2829596) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2829641) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2829762..2829833) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2829762..2829833) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2829859..2829949) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2829859..2829949) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2829953..2830027) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2829953..2830027) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2830038..2830114) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2830038..2830114) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2830130..2830203) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2830130..2830203) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2830214..2830289) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2830214..2830289) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2830307..2830382) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2830307..2830382) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2830395..2830471) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2830395..2830471) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2830483..2830559) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2830483..2830559) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2830577..2830669) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2830577..2830669) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2830676..2830752) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2830676..2830752) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2830755..2830831) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2830755..2830831) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2830851..2830923) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2830851..2830923) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2830929..2831005) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2830929..2831005) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2831021..2831097) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2831021..2831097) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2831107..2831192) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2831107..2831192) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2831207..2831281) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2831207..2831281) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2831287..2831373) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2831287..2831373) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2831384..2831459) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2831384..2831459) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2831497..2831572) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2831497..2831572) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2831605..2831680) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2831605..2831680) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2831701..2831818) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2831701..2831818) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2831874..2834801) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2831874..2834801) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2834969..2836523) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2834969..2836523) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2836325,2836327) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2836524..2836815) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2836651..2836659 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2836657 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2836767 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2836788..2836807) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2836815) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2836817..2837783) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2836821..2836828) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2836940..2836943 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2836955 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2836958..2836977 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2836988..2837089 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2836988..2837089 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2837088 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2837189..2837767 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2837189..2837767 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2837757 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2837809..2838330) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2837809..2838330) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2837827) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2837899) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2838348..2839877) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2838348..2839877) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2839898..2840422) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2839898..2840422) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2840466..2840481) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2840472) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2840474..2840561) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2840493..2840502) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2840546..2840564) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2840556 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2840560..2840579 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2840561) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2840579..2840584) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2840590..2841078 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2840590..2841078 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2841055 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2841084..2841662) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2841084..2841662) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2841100..2841491 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2841111) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2841696..2841715) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841705) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2841729..2841736) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2841750..2842958) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2841750..2842958) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2841771) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2842727..2842746) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2842739) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2842761..2842768) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2842975..2844447) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2842975..2844447) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2844498..2844517) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2844499) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2844532..2844539) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2844559..2844565 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2844579..2844598 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2844594 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2844646..2845188 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2844646..2845188 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2845171 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2845265..2845272 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2845285..2845385 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2845285 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2845287..2845306 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2845386..2845931 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2845386..2845931 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2845918 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2846023..2846030 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2846044..2846063 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2846051 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2846056..2846224 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2846056..2846224 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2846205 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2846297..2846965 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2846297..2846965 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2846972..2848309 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2846972..2848309 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2848295 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2848345..2848608) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2848345..2848608) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2848363) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2848648..2848667) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2848650) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2848680..2848687) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2848717..2849565) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2848717..2849565) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2849610..2849629) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2849620) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2849644..2849651) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2849726..2851261) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2849726..2851261) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2849735) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2850919..2851019 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2850979 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2851045 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2851262..2851429) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2851418..2851437) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2851429) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2851431..2852308) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2851452..2851459) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2851671..2851680 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2851694..2851713 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2851694 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2851746..2852231 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2851746..2852231 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2852232..2852518 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2852338..2852410) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2852338..2852410) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2852353) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2852397) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2852421..2852440) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2852441) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2852455..2852458) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2852475 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2852518..2853348) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2852518..2853348) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2852529) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2853349..2853440) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2853441..2854607) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2853441..2854607) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2854603..2854607 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2854615..2854629 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2854631..2854650) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2854631 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2854650) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2854664..2854671) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2854729..2854736 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2854742 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2854747..2854766 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2854789..2855775 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2854789..2855775 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2855746 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2855816..2857090) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2855816..2857090) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2855829) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2857116..2857430) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2857116..2857430) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2857448..2858905) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2857448..2858905) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2858910..2859686) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2858910..2859686) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2859720..2859739) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2859736) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2859743..2861812) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2859743..2861812) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2861845..2861864) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2861857) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2861878..2861884) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2861950..2863938) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2861950..2863938) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2861969) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2863942..2863949 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2863959..2863977) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2863965..2863984 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2863972) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2863981 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2863991..2863998) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2864047 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2864052..2866037) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2864052..2866037) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2864057) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2866058..2866076) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2866073) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2866075..2866162) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2866090..2866097) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2866163..2868151) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2866163..2868151) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2868176..2868194) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2868191) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2868208..2868215) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2868328..2870316) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2868328..2870316) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2868347) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2870337..2870355) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870358) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870368..2870375) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2870418..2870427 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2870441..2870460 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2870444 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2870474..2871211 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2870474..2871211 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2870499..2870518) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2870507) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2870534..2870538) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2871212..2874032 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2871225..2871479) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2871225..2871479) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2871251) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2871480..2871736) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2871737..2872135) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2871737..2872135) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2872095..2872229) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2872095..2872229) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2872178..2872197) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872185) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2872212..2872218) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2872255..2873919) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2872255..2873919) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2872271) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2873227..2873246) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873232) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2873260..2873267) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2873944..2873962) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873961) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2873978..2873983) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2874046..2875335) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2874046..2875335) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2874055) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2874864..2874870 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2874884..2874902 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2874890 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2874894..2875546 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2875379..2876056) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2875379..2876056) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2875389) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2875731..2876407 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2876091..2876110) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2876098..2876361) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2876098..2876361) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2876112) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2876124..2876131) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2876373..2876391) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2876387) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2876407..2876412) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2876408..2876740 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2876408..2876740 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2876425..2876431 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2876446..2876463 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2876457 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2876737..2877723 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2876737..2877723 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2877698) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2877720..2878124) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2877720..2878124) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2878125..2878183) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2878184..2878555) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2878184..2878555) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2878614..2879966) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2878614..2879966) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2878625) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2878781..2878799) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2878798) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2878815..2878820) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2879939) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2879942..2879953) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2879998..2880017) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2880004) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2880006..2880077) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2880032..2880035) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2880078..2881250) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2880078..2881250) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2880413..2881334 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2881283..2881302) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2881296) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2881319..2881322) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2881354..2882517) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2881354..2882517) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2881369) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2882532..2882551) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2882550) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2882552..2882707) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2882566..2882573) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2882603..2882609 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2882624..2882642 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2882634 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2882635..2882693 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2882680..2882686 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2882682..2882693) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2882695 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2882700..2882711 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2882707..2882713) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2882707) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2882709..2883020) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2882747..2882983 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2882747..2882983 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2882943 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2883009 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2883061..2883453) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2883061..2883453) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2883065) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2883495..2883514) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2883502) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2883504..2883654) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2883530..2883534) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2883557..2883563 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2883570..2884554 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2883570 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2883578..2883596 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2883655..2884815) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2883655..2884815) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2884707..2884713 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2884725 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2884727..2884731 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2884816..2885316) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2884816..2885316) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2885346..2885365) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2885352..2885358 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2885367) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2885373..2885384 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885373 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2885376..2885383) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2885385..2885463 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2885464..2886285 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2885464..2886285 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2886265 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2886312) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2886314..2886574) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2886314..2886574) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2886564..2886567 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2886582..2886601 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2886594 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2886595..2886660 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2886600..2886619) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2886605) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2886631..2886637) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2886661..2887824 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2886661..2887824 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2887887..2887893 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2887905..2887924 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2887915 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2887950..2889236 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2887950..2889236 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2888952..2889694) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2889231..2889238 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2889252..2889271 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2889253 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2889282..2889668 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2889282..2889668 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2889650 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2889695..2890312) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2889695..2890312) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2890347..2890365) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2890364) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2890366..2892454) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2890380..2890385) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2890428..2890431 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2890446..2890465 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2890457 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2890523..2891701 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2890523..2891701 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2891739..2891745 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2891757..2891776 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2891762 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2891794..2893668 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2891794..2893668 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2892434..2892453) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892454) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2892467..2892476) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2893689..2894102 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2893689..2894102 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2894094 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2894305..2894862) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2894305..2894862) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2894326..2894345 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2894336 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2894346) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2894358..2895039 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2894888..2894907) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2894896) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2894923..2894927) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2895040..2896641 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2895040..2896641 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2896634..2897341 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2896634..2897341 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2897326 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2897505..2897512 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2897523..2897812 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2897523 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2897527..2897546 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2897813..2898892 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2897813..2898892 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2898968..2900500 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2898968..2900500 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2900493..2901539 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2900493..2901539 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2901540..2902499 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2901540..2902499 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2902500..2902621 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2902594..2902597 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2902612..2902631 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2902623 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2902653..2903999 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2902653..2903999 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2903982 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2904035..2904250) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2904035..2904250) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2904190..2904196 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2904210..2904221 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2904214 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2904261..2904279) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2904268) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2904293..2904300 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2904295..2904300) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2904315..2904410 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2904315..2904334 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2904315 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2904373..2904377 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2904393..2904412 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2904412..2904561 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2904412 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2904481..2906886 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2904481..2906886 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2906879..2907310 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2906879..2907310 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2907310..2907651 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2907310..2907651 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2907542..2907642 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2907602 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2907644..2909125 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2907644..2909125 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2908377..2910245) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2909131..2909607 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2909131..2909607 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2909607..2909891 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2909607..2909891 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2909875..2910249 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2909875..2910249 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2910220 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2910288..2910668) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2910288..2910668) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2910290) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2910687..2911331) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2910687..2911331) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2911332..2911411) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2911412..2913721) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2911412..2913721) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2912406..2912413 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912427..2912446 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912442 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2913315..2914286 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2913315 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2913327..2913343 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2913736..2913903) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2913736..2913903) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2913891..2914789) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2913891..2914789) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2914790..2914903) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2914897..2914916) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2914903) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2914930..2914936) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2914974..2915114) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2914974..2915114) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2915003) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2915115..2915201) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2915185..2915204) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915201) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2915218..2915224) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2915301..2915319) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915311) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2915334..2915340) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2915336..2915461 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2915336..2915461 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2915489..2915918) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2915514..2915519 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2915531) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2915534..2915552 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2915536 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2915575..2915943 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2915575..2915943 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2915919..2917148) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2915919..2917148) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2915944..2917257 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2917183..2917202) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2917202) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2917215 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2917217..2917224) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2917285..2918757) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2917285..2918757) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2917295) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2918638..2918642 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2918645 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2918755 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2918773..2919324) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2918773..2919324) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2919346..2919365) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2919359) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2919378..2919385) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2919421..2919819) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2919421..2919819) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2919820..2919890) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2919891..2920139) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2919891..2920139) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2920162..2920181) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2920173) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2920197..2920200) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2920212..2920433) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2920212..2920433) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2920239) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2920427 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2920451..2920470) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2920457) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2920483..2920492) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2920493..2921602) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2920493..2921602) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2921254..2921261 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2921276..2921295 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2921285..2921679 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2921285 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2921650..2921669) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2921666) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2921668..2922108) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2921671..2921673 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2921681 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2921683..2921688) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2921689..2921708 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2921717..2922106 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2921717..2922106 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2922147..2922383) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2922147..2922383) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2922153) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2922403..2922422) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2922417) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2922419..2922559) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2922436..2922445) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2922560..2923090) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2922560..2923090) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2923110..2923129) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2923121) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2923123..2923209) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2923141..2923149) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2923204..2923223) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923211) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2923237..2923246) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2923288..2924019) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2923288..2924019) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2923318) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2924034..2924053) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2924045) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2924068..2924075) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2924082..2924537) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2924082..2924537) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2924490..2924496 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924511..2924529 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2924519..2926886 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2924519 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2924569..2927799) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2924569..2927799) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2927796..2932283) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2927796..2932283) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2931558..2931564 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2931579..2931597 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2931585..2932547 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2931585 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2932344..2933699) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2932344..2933699) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2932365) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2933714..2933953) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2933714..2933953) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2934023..2934316) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2934023..2934316) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2934033) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2934310 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2934317..2934395) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2934358..2934365 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2934375..2934394) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2934376 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2934380..2934397 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2934395) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2934409..2934416) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2934454..2934459 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2934474..2934493 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2934486..2934592 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2934486 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2934661..2934667 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2934681..2934700 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2934684 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2934789..2934792 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2934801 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2934804..2934823) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2934808..2934827 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2934826) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2934837..2936105 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2934837..2936105 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2934838..2934845) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2936165..2936184 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2936170 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2936207..2937343 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2936207..2937343 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2937343 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2937392..2937400 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2937410 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2937412..2937430 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2937455..2938132 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2937455..2938132 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2938116 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2938176..2938385) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2938176..2938385) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2938188) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2938401..2945537) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2938401..2945537) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2945557..2946495) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2945557..2946495) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2946523..2948142) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2946523..2948142) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2948171..2949367) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2948171..2949367) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2949215..2949222 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2949237..2949256 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2949244 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2949393..2950178) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2949393..2950178) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2950179..2950288) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2950283..2950302) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950288) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2950290..2950371) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2950316..2950323) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2950372..2951241) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2950372..2951241) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2951242..2951322) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2951306..2951325) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2951322) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2951339..2951346) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2951455..2952051) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2951455..2952051) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2952052..2952136) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2952087..2952094 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2952104 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2952109..2952128 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2952130..2952144) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952136) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2952152..2952156) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2952152..2952754 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2952152..2952754 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2952740 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2952824..2954152) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2952824..2954152) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2952840) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2954206..2954225) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954209) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2954240..2954247) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2954299..2955801) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2954299..2955801) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2954314) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2955366..2955380 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2955382 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2955802..2955876) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2955824..2955831 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2955842..2955861 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2955844..2955958 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2955844 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2955871..2955890) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2955881) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2955959..2956435 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2955959..2956435 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2956384 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2956466..2957122) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2956466..2957122) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2956494) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2956770..2956779 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2956793..2956812 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2956810 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2956812..2957258 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2957136) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2957138..2957149) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2957164..2957170) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2957215 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2957226..2957546) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2957226..2957546) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2957240) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2957260..2957470 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2957412..2957512 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2957472..2957581 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2957472 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2957538 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2957565..2957584) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957570) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2957583..2958134 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2957599..2957606) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2957600..2957743) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2957600..2957743) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2957767..2957786) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957788) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2957802..2957805) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2957916..2959136) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2957916..2959136) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2957944) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2959137..2959264) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2959264) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2959266..2959330) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2959266..2959284) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2959300..2959305) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2959321..2959340) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959329) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2959355..2959362) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2959404..2959411 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959423..2959442 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959423 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2959468..2960466 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2959468..2960466 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2959491..2959509) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959506) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2959526..2959531) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2960442 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2960505..2960645) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2960505..2960645) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2960517) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2960646..2960775) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2960756..2960775) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2960775) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2960777..2961024) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2960789..2960795) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2960832..2960839 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2960853..2960872 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2960861 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2960924..2961904 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2960924..2961904 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2961025) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2961029..2961040) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2961054..2961060) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2961872 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2961977) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2961978..2962601) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2961978..2962601) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2962625..2963143) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2962625..2963143) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2963190..2963209) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2963202) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2963204..2963312) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2963299..2963316) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2963310) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2963331..2963338) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2963466) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2963481..2963843) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2963481..2963843) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2963874..2963893) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2963884) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2963907..2963914) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2963922..2964776) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2963922..2964776) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2964492..2964511) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2964500) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2964524..2964533) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2964798..2964817) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2964812) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2964832..2964835) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2964899..2966113) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2964899..2966113) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2965448..2965454 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2965469..2965487 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2965476 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2965480..2966249 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2966150..2966169) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2966155) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2966184..2966191) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2966206 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2966250..2966486) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2966250..2966486) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2966251..2966667 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2966268) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2966451..2966452) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2966456..2966460) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2966458) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2966501..2966520) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966502) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966534..2966541) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2966644..2966649 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2966663..2966682 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2966669 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2966749..2967816 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2966749..2967816 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2967800 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2967842..2968168) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2967842..2968168) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2967865) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2968200..2968219) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968217) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2968232..2968239) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2968252..2968256 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2968268..2968603 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2968268..2968603 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2968269..2968288 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968274 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2968393) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2968581 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2968645..2970618) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2968645..2970618) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2968657) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2970633..2970651) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2970656) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2970663..2970671) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2970726..2971655) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2970726..2971655) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2970739) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2971652..2972710) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2971652..2972710) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2972710..2974011) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2972710..2974011) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2973896..2973905 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2973920..2973939 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2973927 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2974012..2974093) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2974078..2974097) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974093) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2974095..2974211) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2974112..2974119) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2974212..2975231) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2974212..2975231) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2975039..2975044 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2975060..2975078 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2975064 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2975254..2975272) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2975261) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2975270..2975275 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2975288..2975293) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2975291..2975355 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2975291..2975309 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2975291 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2975328..2975337 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2975350..2975369 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2975357 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2975384..2975884 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2975384..2975884 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2975911..2976681) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2975911..2976681) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2975939) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2976710..2977144) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2976710..2977144) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2977168..2977443) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2977168..2977443) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2977463..2977482) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2977488) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2977490..2978182) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2977496..2977503) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2977506..2977512 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2977527..2977538 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2977535 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2977558..2978190 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2977558..2978190 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2978151 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2978206..2979102) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2978206..2979102) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2978227) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2979103..2979237) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2979224..2979243) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2979237) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2979259..2979263) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2979277..2979283 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2979297..2979308 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2979309 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2979337..2980317 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2979337..2980317 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2979415) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2979429..2979448) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2979465..2979468) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2980309 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2980345..2981109) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2980345..2981109) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2980361) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2981123..2981141) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2981131) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2981157..2981162) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2981182..2981487) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2981182..2981487) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2981190) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2981501..2981520) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2981524) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2981534..2981542) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2981552..2982940) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2981552..2982940) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2982960..2983781) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2982960..2983781) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2983799..2984647) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2983799..2984647) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2984166..2984171 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2984187..2984205 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2984201 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2984658..2984677) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2984673) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2984685..2985032) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2984685..2985032) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2985045..2985064) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2985064) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2985078..2985084) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2985129..2986469) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2985129..2986469) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2985157) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2986213) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2986526..2986532 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986546..2986565 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2986548..2986566) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986554 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2986555..2986643 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2986565) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2986582..2986587) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2986644..2988239 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2986644..2988239 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2988384..2989733 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2988384..2989733 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2989739..2991031 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2989739..2991031 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2991044..2992528 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2991044..2992528 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2992528..2992872 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2992528..2992872 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2992594..2992597 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2992615..2992634 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2992627 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2992847 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2992888..2993275) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2993235..2993244 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2993257..2993276 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2993260 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2993296..2993427) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2993296..2993427 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2993296..2993427 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2993296..2993427) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2993428..2993496 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2993463 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2993633..2994154) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2993633..2994154) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2994145..2996382) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2994145..2996382) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2996383..2997216) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2996383..2997216) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2997213..2997830) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2997213..2997830) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2997322) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2997827..2998819) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2997827..2998819) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2998820..2998906) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2998884..2998903) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998906) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2998917..2998922) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2999048..3000298) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2999048..3000298) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(3000315..3001553) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(3000315..3001553) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 3001776..3001913 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 3001776..3001913 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 3001935..3001938 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3001953..3001972 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3001954 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 3001995..3002861 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 3001995..3002861 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 3002864 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3002895..3003998) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(3002895..3003998) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(3002910) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3003999..3004932) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 3004036..3004043 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3004057..3004076 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3004067 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3004118..3004124 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3004135 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3004139..3004158 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3004180..3004908 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 3004180..3004908 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(3004933..3005787) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(3004933..3005787) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(3005120..3005139) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3005132) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(3005290..3005390) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3005330) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3005801..3006703) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(3005801..3006703) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(3006707..3007585) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(3006707..3007585) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(3007643..3008911) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(3007643..3008911) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 3008802..3008902 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3008862 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3008982) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(3008992..3009978) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(3008992..3009978) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 3009925 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3009928..3009932 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3010021..3010040) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3010034) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3010055..3010062) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3010192) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3010194..3010568) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(3010194..3010568) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(3010632) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3010639..3010650) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3010664..3010670) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3010671..3011789) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(3010671..3011789) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(3011814..3011833) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3011820) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3011822..3012432) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(3011847..3011853) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3011886..3011895 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3011909..3011928 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3011913 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3011926..3011941) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3011930) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3011948..3011952) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3011948..3012094 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 3011948..3012094 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 3012094..3012369 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 3012094..3012369 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(3012238) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3012254..3012268) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3012277..3012281) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3012349 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3012433..3012816) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(3012433..3012816) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(3012817..3012926) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(3012927..3013205) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(3012927..3013205) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(3013203..3013222) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3013227) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3013237..3013244) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3013368..3013474) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(3013411) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3013475..3014872) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(3013475..3014872) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 3014670 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(3014893..3015336) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(3014893..3015336) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(3015326..3016546) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(3015326..3016546) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(3016546..3017859) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(3016546..3017859) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(3017877..3018662) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(3017877..3018662) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(3018706..3018725) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3018707) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(3018739..3018746) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(3018763..3018782) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3018772) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(3018774..3018855) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(3018798..3018802) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(3018819..3019066) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(3018819..3019066) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(3018856..3018993) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(3018856..3018993) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(3018994..3019078) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(3019062..3019081) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3019078) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3019080..3019186) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(3019097..3019100) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3019187..3019564) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(3019187..3019564) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(3019581..3019592) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(3019587) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(3019606..3019612) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(3019649..3020473) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(3019649..3020473) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(3019657) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(3019806) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 3019833..3019838 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3019854..3019872 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3019856 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3020487..3021155) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(3020487..3021155) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(3021148..3022173) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(3021148..3022173) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(3022174..3022278) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(3022279..3022385) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(3022279..3022385) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 3022348 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3022412..3022431) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3022424) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3022426..3022499) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(3022447..3022454) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3022500..3022844) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(3022500..3022844) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(3022845..3022950) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(3022951..3023271) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(3022951..3023271) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(3023273..3023713) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(3023273..3023713) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(3023713..3023949) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(3023713..3023949) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(3023725) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(3023964) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3023969..3023980) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3023995..3024001) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3024005..3024388) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(3024005..3024388) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(3024415..3024434) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(3024426) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(3024447..3024454) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(3024455..3024811) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(3024455..3024811) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(3024834..3024853) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(3024844) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(3024867..3024872) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(3024922..3026706) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(3024922..3026706) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(3024932) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3026721..3027896) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(3026721..3027896) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(3027907..3030276) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(3027907..3030276) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 3029695..3029700 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3029715..3029733 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3029718 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3030344..3030363) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(3030347) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(3030355..3030621) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(3030377..3030384) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 3030402..3030408 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3030423..3030434 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3030445 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 3030451..3030597 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 3030451..3030597 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 3030598..3031624 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(3030622..3031530) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(3030622..3031530) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(3031531..3032053) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 3031625..3031870 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 3031625..3031870 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 3031883..3032215 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 3031883..3032215 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(3032036..3032055) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032053) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3032069..3032078) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3032204 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3032276..3032283 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3032297..3032316 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3032308 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 3032374..3032841 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 3032374..3032841 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 3032838..3034463 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 3032838..3034463 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 3034448 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3034499..3034882) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(3034499..3034882) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(3034901..3035290) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(3034901..3035290) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(3035312..3035641) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(3035312..3035641) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(3035676..3035695) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3035683..3035690 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3035690) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3035705..3035724 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3035709..3035716) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3035715 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 3035775..3036662 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 3035775..3036662 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(3036682..3036969) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(3036682..3036969) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(3036694) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(3036994..3037821) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(3036994..3037821) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(3037010) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(3037822..3037959) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3037944..3037963) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037959) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3037979..3037982) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3038039..3038476) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(3038039..3038476) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(3038500..3038518) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3038506) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(3038534..3038539) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3038586..3040094) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(3038586..3040094) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(3038607) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(3040085..3040381) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(3040085..3040381) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(3040404..3040423) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040420) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3040438..3040441) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3040458..3040463 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3040475..3040494 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3040475 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 3040515..3041357 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 3040515..3041357 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 3040887..3040893 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3040908..3040919 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3040916 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 3041384..3041391 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3041400 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3041403..3041422 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3041447..3041908 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 3041447..3041908 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 3041884 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3041952..3043328) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(3041952..3043328) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(3041960) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(3043329..3043500) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3043481..3043500) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043500) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3043511..3043518) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3043561..3043580) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3043571..3043590 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3043573 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3043579) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(3043581..3044644) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3043595..3043602) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3043606..3044283 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 3043606..3044283 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 3044280..3045635 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 3044280..3045635 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(3044734..3045662) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3045603 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3045663..3045827) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(3045663..3045827) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 3045851..3045858 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3045872..3045891 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3045876..3045895) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3045882..3045994 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3045882 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3045889) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3045891..3046169) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3045909..3045916) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3045995..3046870 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 3045995..3046870 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(3046159..3046178) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046169) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3046171..3046712) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3046192..3046199) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3046704..3046722) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046712) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3046714..3046843) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3046735..3046742) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3046845 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(3046888) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3046906..3048294) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(3046906..3048294) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(3048318) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3048323..3048341) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3048352..3048360) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3048361..3048546) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(3048361..3048546) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 3048550 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3048590..3048609) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3048599..3048605 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3048604) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3048619..3048630 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3048622 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3048625..3048628) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3048664..3050112 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 3048664..3050112 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(3049660..3052303) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3050081..3051178 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 3050081..3051178 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 3051175..3052296 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 3051175..3052296 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(3052304..3052939) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(3052304..3052939) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(3052917..3053999) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(3052917..3053999) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(3053996..3054721) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(3053996..3054721) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(3054755..3055627) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(3054755..3055627) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(3055646..3055665) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3055666) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3055680..3055683) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3055728..3056405) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(3055728..3056405) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(3055744) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(3056432..3056812) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(3056432..3056812) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(3056835..3056854) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3056855) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3056869..3056872) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3056974..3058242) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(3056974..3058242) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(3056987) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3058276..3058295) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3058287) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3058310..3058317) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3058413) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3058419..3059000) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(3058419..3059000) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(3059023..3060351) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(3059023..3060351) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(3060351..3061412) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(3060351..3061412) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(3061375..3062319) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(3061375..3062319) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(3062320..3062589) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3062428..3062558) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(3062428..3062558) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(3062566..3062585) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3062589) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3062591..3063518) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3062601..3062608) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3062651..3062658 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3062673..3062692 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3062677 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 3062717..3063508 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 3062717..3063508 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 3063379 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3063489 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3063546..3064424) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(3063546..3064424) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(3063563) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3064448..3064466) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3064467) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3064480..3064486) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3064496..3066238) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(3064496..3066238) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(3066235..3066948) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(3066235..3066948) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(3066979..3066998) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3066997) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(3067101..3067340) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(3067101..3067340) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(3067108) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3067336..3067354) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3067344..3067874) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(3067344..3067874) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(3067345) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3067369..3067375) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3067877..3067896) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067884) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 3067889..3068227 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 3067889..3068227 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(3067911..3067918) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3067927..3067946) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067939) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3067961..3067967) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3067973..3068073 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3068033 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 3068201..3068301 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3068261..3068347 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3068261 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 3068348..3069505 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 3068348..3069505 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 3069491 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3069566..3069976 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 3069566..3069976 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 3069975 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3070010..3071239) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(3070010..3071239) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(3070027) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(3071232..3071921) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(3071232..3071921) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(3071905..3073098) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(3071905..3073098) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(3073142..3073161) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3073155) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3073176..3073183) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3073269..3074078) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(3073269..3074078) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(3073286) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3073425..3073434 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3073447..3073466 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3073451 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3074094..3075104) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(3074094..3075104) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(3075104..3076258) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(3075104..3076258) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(3076191..3076210) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3076208) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3076222..3076229) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3076270..3076277 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3076292..3076311 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3076301 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 3076356..3077303 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 3076356..3077303 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 3077279 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 3077323 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 3077477 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3077538..3078947) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(3077538..3078947) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(3077553) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3078365..3078369 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3078387..3078403 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3078394 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 3078401..3079368 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3079049) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3079051..3079230) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(3079051..3079230) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(3079260..3079277) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079271) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3079292..3079299) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3079325 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3079347..3079487) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(3079347..3079487) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(3079357) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(3079515) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(3079517..3080105) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3079520..3079531) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3079545..3079551) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3079577..3079584 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3079598 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3079600..3079619 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3079654..3080136 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 3079654..3080136 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 3080150..3080157 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3080171..3080190 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3080183 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3080236..3082089 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 3080236..3082089 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 3082075 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3082117..3083043) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(3082117..3083043) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(3082129) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3083055..3083074) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3083076) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3083090..3083093) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3083112..3083131 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3083121 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 3083154..3083936 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 3083154..3083936 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 3083908..3084600 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 3083908..3084600 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 3084592 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(3084631..3085461) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(3084631..3085461) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(3084637) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 3085324..3085328 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3085344..3085348 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3085353 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3085463 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3085491..3085510) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085509) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3085525..3085532) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3085617..3085623 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3085637 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3085638..3085656 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3085684..3086169 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 3085684..3086169 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 3086168 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(3086213..3088225) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(3086213..3088225) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(3086221) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3087891..3087895) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3087893) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3088226..3088377) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3088354..3088372) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3088377) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3088480..3090195) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(3088480..3090195) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(3088487) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(3090221..3092038) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(3090221..3092038) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(3092080..3092099) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3092089..3092096 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3092099) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 3092102 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3092109..3092128 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3092112..3092119) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3092209..3094533) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(3092209..3094533) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(3092227) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3094553..3094560 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3094575..3094594 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3094576..3094591) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3094579 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3094581) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3094626..3094645) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3094635) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3094661..3094667) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3094671..3094690) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3094691) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3094704..3094712) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3094718) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(3094731..3095339) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(3094731..3095339) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(3095378..3095397) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3095395) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3095413..3095417) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3095526..3095942) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(3095526..3095942) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(3095536) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3095947..3096615) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(3095947..3096615) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(3096667..3096686) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096682) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3096693) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3096700..3096705) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3096735..3098843) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(3096735..3098843) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(3098835..3098936) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3098930..3098949) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3098936) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3098965..3098972) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3099003..3101411) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(3099003..3101411) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(3099025) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3099091) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3101412..3101494) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3101495..3101704) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(3101495..3101704) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(3101728..3101747) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3101749) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(3101760..3101766) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3101778..3102083) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(3101778..3102083) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 3102047..3102066 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3102058 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3102097..3102116) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3102123) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(3102130..3102136) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3102175..3102181 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3102196..3102214 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3102204 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 3102211..3103287 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 3102211..3103287 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 3103274 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3103324..3103959) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(3103324..3103959) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(3103337) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3103960..3104057) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3104037..3104056) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3104057) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3104070..3104076) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3104119..3106014) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(3104119..3106014) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(3106065..3106076) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3106065) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3106091..3106097) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3106164) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3106177..3106578) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(3106177..3106578) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(3106575..3106934) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(3106575..3106934) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(3106931..3107503) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(3106931..3107503) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(3107541..3107560) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3107546) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3107574..3107581) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3107614..3108408) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(3107614..3108408) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(3108429..3108447) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3108441) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3108462..3108468) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3108474..3108493) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3108485) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3108487..3108552) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3108507..3108514) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3108594..3108953) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(3108594..3108953) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(3108597) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3108937..3108945) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3108947) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3108960..3108965) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3109005..3109024) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109013) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3109015..3109079) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3109037..3109041) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3109079) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(3109080..3109099) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3109114..3109121) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3109130..3109600) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(3109130..3109600) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 3109427..3109527 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3109487 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3109597 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3109645..3109664) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3109651) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(3109653..3109744) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3109680..3109683) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3109745..3112084) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(3109745..3112084) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 3110845..3110848 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3110864..3110867 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3110873 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3112103..3112843) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(3112103..3112843) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(3112499..3112517) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3112511) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(3112532..3112538) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3112871..3112889) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3112885) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(3112973) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(3112975..3113205) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(3112975..3113205) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(3113235..3113254) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3113256) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(3113269..3113272) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3113294..3113300 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3113314..3113325 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3113315 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 3113354..3114124 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 3113354..3114124 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 3113376..3113384 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3113395..3113413 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3113425 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3114164..3114397) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(3114164..3114397) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 3114488..3114495 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3114503 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 3114507..3114526 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3114549..3114956 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 3114549..3114956 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 3114986..3115405 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 3114986..3115405 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 3115443..3115450 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3115464..3115483 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3115471 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3115497..3115823 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 3115497..3115823 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 3115824..3115908 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3115879..3115886 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3115899..3115917 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3115910 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3115948..3117648 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 3115948..3117648 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(3116664..3117657) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3117626 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3117688..3118368) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(3117688..3118368) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(3117702) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3118062..3118068 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3118083..3118101 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3118088..3120839 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3118088 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3118385..3119305) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(3118385..3119305) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(3119317..3119970) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(3119317..3119970) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(3119987..3121132) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(3119987..3121132) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(3121133..3121200) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3121200) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3121201..3121220) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3121231..3121235 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3121235..3121238) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3121251..3121269 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3121256 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3121351..3121355 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3121371..3121390 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3121374 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 3121416..3121949 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 3121416..3121949 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(3121616..3122135) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3121938 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3122072..3122079 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3122092..3122170 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3122092 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3122094..3122113 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3122120..3122134) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122135) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" CDS 3122171..3122647 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" /label="sdpA CDS" gene 3122171..3122647 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /label="sdpA gene" promotor_-10 complement(3122196..3122215) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122206) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3122227..3122234) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3122644..3123615 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" /label="sdpB CDS" gene 3122644..3123615 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /label="sdpB gene" promotor_no_box 3123452..3123552 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3123512 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3123524..3123541) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3123545) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3123547..3123949) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3123558..3123560) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3123576) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 3123658..3124269 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" /label="spbC CDS" gene 3123658..3124269 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /label="spbC gene" S_feature complement(3123951..3124037) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3123994) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature complement(3124039..3124224) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3124082) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3124249 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" /label="downshifts" downshifts complement(3124269) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" /label="downshifts" S_feature 3124294..3125432 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3124316..3124939) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" /label="sdpI CDS" gene complement(3124316..3124939) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /label="sdpI gene" downshifts complement(3124324) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3124936..3125208) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" /label="sdpR CDS" gene complement(3124936..3125208) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /label="sdpR gene" promotor_-10 complement(3125264..3125283) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3125273) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3125275..3125423) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3125295..3125301) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3125428..3126117) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(3125428..3126117) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(3125468) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 3126060..3126068 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3126082..3126101 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3126096 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3126135..3127046) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(3126135..3127046) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(3127066..3127719) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(3127066..3127719) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(3127742..3128884) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(3127742..3128884) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(3128928..3128947) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3128943) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(3128962..3128965) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3129081..3129088 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3129101..3129120 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3129112 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 3129148..3129705 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 3129148..3129705 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 3129706..3130470 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3129723..3130358) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(3129723..3130358) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(3129736) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3130399..3130417) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130405) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3130433..3130439) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3130444..3130451 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130463..3130482 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3130472 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3130508..3131122 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 3130508..3131122 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 3131108 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 3131176..3131179 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3131194..3131213 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3131202 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3131254..3131952 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 3131254..3131952 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 3131925 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3131988..3133805) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(3131988..3133805) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(3132007) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(3132178) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(3133847..3133866) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3133851..3133870 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3133856 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3133860) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3133925..3134392 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 3133925..3134392 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 3134389 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3134437..3135729) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(3134437..3135729) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(3134447) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3135759..3137294) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(3135759..3137294) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(3137287..3138048) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(3137287..3138048) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(3138079..3139263) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(3138079..3139263) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(3139264..3139504) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3139504) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3139506..3139579) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3139518..3139537) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3139553..3139557) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3139580..3140587) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(3139580..3140587) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 3140506..3140509 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140526..3140528 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140528 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3140634..3141656) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(3140634..3141656) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(3140650) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140678..3140679) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3141657..3141768) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3141694 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3141749..3141768) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3141768) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3141770..3141880) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3141782..3141789) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3141863..3141882) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3141878) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(3141895..3141904) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3141954..3143348) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(3141954..3143348) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(3141968) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3143447..3143466) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3143461) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3143481..3143488) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3143488..3143495 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3143509..3143528 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3143515 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 3143552..3144640 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 3143552..3144640 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 3144620 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3144689..3145699) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(3144689..3145699) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(3144696) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3145700..3145777) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3145767..3145786) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145777) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3145800..3145807) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3145856..3146734) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(3145856..3146734) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 3146392..3146398 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146413..3146424 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146424 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3146768..3146775 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3146781..3146800) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3146786) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 3146789..3146808 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146791 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3146814..3146818) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3146834..3147751 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 3146834..3147751 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 3147740 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3147792..3149135) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(3147792..3149135) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(3149204..3149439) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(3149204..3149439) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(3149338) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3149440..3149536) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3149537..3150571) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(3149537..3150571) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(3150593..3150611) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150599) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3150624..3150631) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3150679..3151401) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(3150679..3151401) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(3150695) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(3151401..3152840) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(3151401..3152840) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 3152388..3152391 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3152408 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3152409..3152413 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3152562 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3152716 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3152717..3152718 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3152867..3153583) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(3152867..3153583) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 3153487..3153494 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3153508..3153510 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3153508 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3153581 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(3153584..3153650) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3153647..3153666) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3153650) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(3153681..3153688) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3153758..3154360) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(3153758..3154360) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(3154377..3155492) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(3154377..3155492) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(3155496..3156233) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(3155496..3156233) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(3155522..3155541) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3155536) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(3155553..3155560) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3156234..3157139) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(3156234..3157139) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(3157159..3157177) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157170) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3157193..3157196) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3157348..3157355 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3157366..3157385 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3157373 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 3157423..3158232 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 3157423..3158232 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 3158268..3159479 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 3158268..3159479 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 3159466 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3159533..3160822) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(3159533..3160822) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(3160902..3162965) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(3160902..3162965) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(3162984..3163835) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(3162984..3163835) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(3163839..3165095) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(3163839..3165095) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(3165135..3166400) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(3165135..3166400) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(3166432..3166451) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3166454) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3166466..3166473) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3166541..3167533) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(3166541..3167533) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(3166575) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(3167663..3167712) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3167686) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3167713..3168372) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(3167713..3168372) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(3168373..3168478) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3168470..3168489) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168479) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3168504..3168507) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3168531..3168538 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3168553..3168572 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3168553 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 3168556..3168661 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3168562..3168579) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168566) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3168587..3168593) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3168662..3170353 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 3168662..3170353 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 3170338 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3170380..3171690) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(3170380..3171690) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 3170383..3171453 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3170392) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3171510..3171529 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3171510..3171768 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3171510 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3171704..3171723) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3171719) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3171738..3171741) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3171769..3171987 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 3171769..3171987 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 3171966 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3171997..3172965) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" /label="epsO CDS" gene complement(3171997..3172965) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /label="epsO gene" CDS complement(3172944..3174110) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" /label="epsN CDS" gene complement(3172944..3174110) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /label="epsN gene" CDS complement(3174115..3174765) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" /label="epsM CDS" gene complement(3174115..3174765) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /label="epsM gene" CDS complement(3174762..3175370) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" /label="epsL CDS" gene complement(3174762..3175370) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /label="epsL gene" CDS complement(3175367..3176884) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" /label="epsK CDS" gene complement(3175367..3176884) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /label="epsK gene" CDS complement(3176881..3177915) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" /label="epsJ CDS" gene complement(3176881..3177915) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /label="epsJ gene" CDS complement(3177912..3178988) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" /label="epsI CDS" gene complement(3177912..3178988) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /label="epsI gene" CDS complement(3178993..3180027) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" /label="epsH CDS" gene complement(3178993..3180027) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /label="epsH gene" CDS complement(3180052..3181155) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" /label="epsG CDS" gene complement(3180052..3181155) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /label="epsG gene" CDS complement(3181152..3182306) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" /label="epsF CDS" gene complement(3181152..3182306) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /label="epsF gene" CDS complement(3182299..3183135) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" /label="epsE CDS" gene complement(3182299..3183135) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /label="epsE gene" CDS complement(3183132..3184277) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" /label="epsD CDS" gene complement(3183132..3184277) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /label="epsD gene" CDS complement(3184289..3186085) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" /label="epsC CDS" gene complement(3184289..3186085) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /label="epsC gene" S_feature complement(3186086..3186145) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3186119..3186137) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186145) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3186151..3186157) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3186344..3187027) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" /label="epsB CDS" gene complement(3186344..3187027) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /label="epsB gene" CDS complement(3187033..3187737) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" /label="epsA CDS" gene complement(3187033..3187737) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /label="epsA gene" upshifts 3187719 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3187722..3187740 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3187738..3187795) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3187791..3187810) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3187796) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3187824..3187831) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3187913..3187918 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3187933..3187952 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3187939 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="upshifts" CDS 3187983..3188441 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" /label="slrR CDS" gene 3187983..3188441 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /label="slrR gene" promotor_-35 3188463..3188466 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3188472 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3188483..3188501 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3188517..3189986 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 3188517..3189986 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 3189963 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 3189989..3190180 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 3189989..3190180 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 3190159 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(3190207..3190692) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(3190207..3190692) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(3190715..3191026) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(3190715..3191026) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(3191078..3191170) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(3191078..3191170) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(3191210..3191229) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3191227) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3191243..3191250) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3191301..3191984) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(3191301..3191984) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(3191319) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(3192000..3193355) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(3192000..3193355) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(3193367..3193382) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3193383) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3193394..3193403) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3193657..3193664 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3193678..3193697 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193681 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 3193703..3193893 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3193894..3195315 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 3193894..3195315 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 3195309 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3195389..3196939 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 3195389..3196939 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 3196983..3196989 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3197003..3197014 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3197003 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 3197047..3198609 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 3197047..3198609 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 3198587 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3198599..3199288 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 3198599..3199288 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 3198638..3198645 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3198659..3198678 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3198668 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 3199269 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(3199367) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 3199370..3199705 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 3199370..3199705 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 3199705..3200025 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 3199705..3200025 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 3200026..3200216 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3200061..3200573) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(3200061..3200573) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 3200193 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3200609..3200620) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3200615) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3200635..3200641) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3200688..3200824) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3200731) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(3200825..3202168) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(3200825..3202168) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(3202197..3202216) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3202205) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3202229..3202238) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3202230..3202235 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3202251..3202269 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3202254 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3202463..3202472 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3202481 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3202486..3202505 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3202524..3203486 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 3202524..3203486 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 3203487..3203740 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3203767) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(3203771..3203846) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(3203771..3203846) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(3203873..3203892) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203894) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3203908..3203911) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3203977..3203983 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3203993..3204068 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3203993 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3203998..3204017 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3204045..3204052 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3204066..3204085 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3204070 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 3204116..3204709 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 3204116..3204709 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 3204698 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 3204743..3205141 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3204755..3205435) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(3204755..3205435) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(3204779) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(3205432..3207117) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(3205432..3207117) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(3207110..3209383) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(3207110..3209383) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(3209361..3210245) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(3209361..3210245) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(3210251..3211087) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(3210251..3211087) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(3211088..3212395) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(3211088..3212395) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 3211453..3211462 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3211475..3211494 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3211479 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3212435..3213688) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(3212435..3213688) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(3213689..3213783) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3213784..3215553) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(3213784..3215553) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 3215474..3215479 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3215495..3215513 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3215505 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3215591..3215610) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3215604) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3215623..3215630) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3215666..3216616) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(3215666..3216616) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(3216631..3216649) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3216644) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3216661..3216669) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3216750) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3216822..3217397) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(3216822..3217397) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(3216834) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3217440..3217459) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3217446..3217453 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3217456) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3217463 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3217466..3217485 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3217474..3217481) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3217514..3217834 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3217514..3217834 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3217815 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3217861) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3217861..3219453) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3217861..3219453) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3219472..3220065) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3219472..3220065) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3220107..3220126) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3220120) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3220141..3220145) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3220191..3220196 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3220212..3220230 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3220213 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3220386..3220393 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3220407..3220426 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3220411 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3220448..3221425 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3220448..3221425 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3221397 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3221463..3223403) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3221463..3223403) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3221487) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3223378..3224157) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3223378..3224157) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3224158..3224239) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3224240..3225310) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3224240..3225310) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3225304..3226017) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3225304..3226017) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3226063..3226082) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3226075) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3226077..3226338) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3226095..3226098) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3226098..3226105 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226116..3226135 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3226121 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3226164..3226373 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3226164..3226373 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3226351 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3226383) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3226409..3227173) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3226409..3227173) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3226431) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3227174..3227431) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3227174..3227431) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3227455..3228405) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3227455..3228405) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3228428..3229381) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3228428..3229381) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3229383..3230270) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3229383..3230270) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3230295..3230771) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3230295..3230771) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3230791..3230810) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230805) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230826..3230830) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3230849..3230868) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230862) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230883..3230886) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3230938..3231088) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3230981) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3231089..3232039) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3231089..3232039) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3232040..3232127) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3232116..3232135) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232127) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3232129..3232220) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3232150..3232153) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3232168..3232174 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3232188..3232206 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3232202 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3232203..3235589 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3232245..3233666) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3232245..3233666) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3232265) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3232389) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3233293..3233297 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3233303 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3233582..3233586 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3233589 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3233667..3233864) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3233787 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3233852..3233871) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3233864) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3233883..3233890) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3234047..3235501) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3234047..3235501) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3234067) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3235502..3235626) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3235547 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3235627..3237396) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3235627..3237396) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3237397..3237471) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3237460..3237479) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3237471) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3237561..3237920) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3237561..3237920) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3237581) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3237935..3239845) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3237935..3239845) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3239847..3240572) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3239847..3240572) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3240573..3240661) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3240661..3240680) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240661) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3240663..3240792) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3240696..3240699) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3240818..3241447) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3240818..3241447) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3240837) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3241444..3242202) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3241444..3242202) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3242199..3242936) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3242199..3242936) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3242933..3243571) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3242933..3243571) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3243429..3243529 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3243489 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3243572..3244156) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3243572..3244156) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3244153..3245436) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3244153..3245436) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3245433..3246074) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3245433..3246074) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3246067..3247242) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3246067..3247242) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3247243..3247320) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3247286..3247292 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3247304..3247323 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3247304..3247323) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3247317 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3247320) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3247336..3247343) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3247452..3247471 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3247459 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3247493..3248245 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3247493..3248245 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3248246..3248484 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3248267..3248278) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3248273) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3248293..3248299) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3248485..3249150 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3248485..3249150 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3249121 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3249170..3249688) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3249170..3249688) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3249204) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3249692..3250342) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3249692..3250342) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3250339..3251277) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3250339..3251277) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3251301..3252110) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3251301..3252110) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3252124..3253056) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3252124..3253056) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3253098..3253117) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3253104) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3253133..3253138) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3253173..3253180 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3253192 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3253195..3253212 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3253238..3254428 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3253238..3254428 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3254226..3254232 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3254247 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3254248..3254266 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3254425..3255153 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3254425..3255153 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3255171..3255902 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3255171..3255902 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3255922..3259791) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3255922..3259791) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3256044) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3259811..3259822) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259818) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3259837..3259843) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3259881..3259887 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3259901..3259920 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3259906 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3259956..3260429 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3259956..3260429 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3260430..3260537 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3260470..3261687) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3260470..3261687) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3260483) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3260509..3260514 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3260529..3260540 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3260539..3260824 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3260539 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3260781 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3261703..3262449) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3261703..3262449) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3262450..3262636) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3262622..3262641) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3262636) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3262655..3262662) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3262770..3262777 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3262792..3262811 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3262804 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3262805..3262874 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3262875..3263384 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3262875..3263384 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3263280..3264618) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3263321) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3263405..3264616 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3263405..3264616 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3264614 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3264644..3265003) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3264644..3265003) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3264659..3265375 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3264663) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3265005..3265202) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3265005..3265202) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3265207..3266304) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3265207..3266304) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3266329..3266655) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3266329..3266655) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3266708..3266723) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266723) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3266725..3267215) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3266735..3266744) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3266803..3266806 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3266821..3266840 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3266831 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3266873..3267103 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3266873..3267103 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3267206..3267225) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3267216) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3267241..3267245) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3267302..3267784) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3267302..3267784) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3267310 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3267325) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3267457) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3267465..3267468) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3267545..3267549) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267545) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3267565..3267568) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3267785..3267918) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3267946..3270819) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3267946..3270819) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3267963) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3270827..3272812) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3270827..3272812) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3272846..3272865) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272858) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3272860..3272945) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3272877..3272884) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3272990) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3272998..3273228) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3272998..3273228) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3273255..3273274) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3273265) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3273267..3273331) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3273288..3273295) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3273308..3273326) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273329) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273341..3273347) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3273397) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3273423..3273523) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3273463) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3273545..3273552 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273566..3273585 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3273583 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3273675..3276170 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3273675..3276170 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3276185..3276189 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3276203 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3276246..3276815 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3276246..3276815 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3276846..3278180 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3276846..3278180 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3278161 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3278228..3279421) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3278228..3279421) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3278237) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3278302) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3279422..3279499) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3279425) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3279500..3279838) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3279500..3279838) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3279813..3279929) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3279813..3279929) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3279930..3280019) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3280001..3280019) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3280019) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3280021..3280101) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3280033..3280038) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3280087..3280105) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3280101) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3280119..3280126) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3280238..3281680) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3280238..3281680) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3280327) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3281726..3281737) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3281737) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3281752..3281758) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3281820..3282710) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3281820..3282710) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3281837) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3282703..3283389) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3282703..3283389) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3283390..3283522) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3283512..3283531) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283522) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3283546..3283549) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3283623..3283961) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3283623..3283961) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3283624) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3283988..3284007) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3284001) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3284010..3284894) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3284010..3284894) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3284021..3284028) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3284882..3284901) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3284903) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3284916..3284923) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3286051..3286122), complement(3285021..3286049)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3285021..3286122) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3285037) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3286123..3286191) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3286192..3288717) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3286192..3288717) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3288718..3288798) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3288788..3288807) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3288798) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3288885..3289454) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3288885..3289454) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3288893) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3289421..3289427 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3289440..3289459 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3289447 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3289481..3289499) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3289489) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3289491..3289611) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3289511..3289519) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3289595..3289613) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3289611) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3289629..3289634) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3289645..3290022) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3289645..3290022) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3290032..3290373) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3290032..3290373) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3290370..3290771) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3290370..3290771) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3290793..3292289) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3290793..3292289) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3292307..3292636) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3292307..3292636) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3292633 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3292658..3292676) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3292673) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3292675..3292779) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3292690..3292697) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3292768..3292787) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3292779) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3292869..3293783) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3292869..3293783) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3292889) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3293784..3293892) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3293850..3293851 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3293860..3293874 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3293869 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3293871..3293889) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3293892) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3293902..3293909) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3293928..3294152) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3293928..3294152) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3293967) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3294146..3294577) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3294146..3294577) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3294598..3295173) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3294598..3295173) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3295220..3296116) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3295220..3296116) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3295243) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3295532..3295535 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3295541 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3296127..3297650) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3296127..3297650) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3297669..3298151) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3297669..3298151) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3298167..3298433) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3298167..3298433) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3298434..3298513) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3298514..3298933) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3298514..3298933) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3298972..3298990) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298983) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3299004..3299011) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3299007..3299729) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3299007..3299729) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3299693..3299989) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3299693..3299989) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3300015..3300034) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3300028) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3300045..3300052) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3300049..3301440) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3300049..3301440) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3301454..3301473) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3301469) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3301487..3301494) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3301546..3302391) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3301546..3302391) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3301557) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3301808..3301815 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3301829..3301848 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3301839..3303571 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3301839 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3302418..3302437) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302437) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3302452..3302455) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3302489..3303178) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3302489..3303178) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3302503) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3303179..3303260) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3303261..3304418) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3303261..3304418) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3304419..3304546) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3304466..3304469 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3304484..3304503 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3304495..3304581 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3304495 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3304540..3304559) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3304546) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3304563..3304571 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3304570..3304577) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3304583 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3304585..3304593 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3304635..3305288 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3304635..3305288 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3304991..3305583) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3305288..3306463 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3305288..3306463 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3305579..3305597) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305588) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3305611..3305617) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3306435 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3306536..3307612) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3306536..3307612) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3306552) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3306598..3306607 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3306621..3306640 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3306629..3307862 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3306629 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3307613..3307695) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3307683..3307702) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307695) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3307714..3307720) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3307757..3308950) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3307757..3308950) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3307787) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3308979..3309737) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3308979..3309737) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3309761..3310441) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3309761..3310441) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3310470..3311936) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3310470..3311936) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3311937..3312020) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3312021..3313406) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3312021..3313406) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3313468..3314637) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3313468..3314637) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3314634..3316085) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3314634..3316085) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3316141..3316290) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3316141..3316290) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3316235..3316774) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3316235..3316774) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3316830..3316847) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3316834) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3317001..3318491) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3317001..3318491) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3317023) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3318530..3320647) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3318530..3320647) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3320671..3320979) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3320671..3320979) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3320885 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3320975..3320979 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3320988..3321002 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3320989..3321007) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3320995 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3321021..3321028) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3321024) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3321045..3321053 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3321067..3321080 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3321085 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3321163..3322083 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3321163..3322083 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3322073 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3322123..3323265) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3322123..3323265) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3322147) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3323304..3323323) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323318) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3323338..3323341) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3323394..3323398 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3323414..3323433 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3323415..3323510 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3323416 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3323511..3324389 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3323511..3324389 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3324390..3325481 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3324459..3324814) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3324723..3324941 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3324723..3324941 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3324815..3324898) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3324815..3324898) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3324899..3325090) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3325091..3327793) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3325091..3327793) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3327794..3327916) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3327815..3327821 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3327836..3327854 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3327841..3330673 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3327841 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3327917..3329257) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3327917..3329257) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3329298..3329504) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3329298..3329504) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3329505..3330378) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3330372..3330391) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3330378) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3330380..3330619) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3330404..3330410) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3330601..3330619) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3330619) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3330633..3330640) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3330642..3330649 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330661..3330680 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3330675..3330805 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3330675 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3330747..3330847 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3330807 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3330811..3331407 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3330811..3331407 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3331005 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3331446..3333029) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3331446..3333029) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3331489 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3333049..3333876) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3333049..3333876) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3333877..3333941) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3333937..3333956) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333941) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3333943..3334040) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3333972..3333975) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3334041..3336281) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3334041..3336281) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3336281..3338302) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3336281..3338302) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3337044..3337053 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3337066..3337081 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3337077 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3338303..3338462) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3338463..3338852) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3338463..3338852) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3338853..3338987) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3338971..3338990) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338987) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3339001..3339008) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3339142..3339148 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3339159..3339251 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3339159 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3339160..3339179 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3339252..3340022 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3339252..3340022 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3339379..3339727) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3339731..3339742) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3339735) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3339757..3339763) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3340047 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3340055..3341200 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3340055..3341200 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3341188 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3341242..3341249 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3341264..3341283 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3341274 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3341320..3342648 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3341320..3342648 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3342643 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3342704) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3342708..3345350) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" /label="lytD CDS" gene complement(3342708..3345350) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /label="lytD gene" promotor_-10 complement(3343953..3343972) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343955) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343985..3343994) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3345385..3345403) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345390) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3345417..3345424) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3345479..3346429) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" /label="pmiA CDS" gene complement(3345479..3346429) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /label="pmiA gene" downshifts complement(3345491) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3346454..3346472) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3346459) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3346461..3346597) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3346487..3346493) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3346571..3346590) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3346599) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3346627..3346633 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3346647..3346658 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3346647 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="upshifts" CDS 3346694..3348145 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" /label="gerBA CDS" gene 3346694..3348145 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /label="gerBA gene" CDS 3348151..3349257 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" /label="gerBB CDS" gene 3348151..3349257 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /label="gerBB gene" CDS 3349254..3350378 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" /label="gerBC CDS" gene 3349254..3350378 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /label="gerBC gene" S_feature complement(3349481..3350375) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3350368 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3350415..3351788) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" /label="ywtG CDS" gene complement(3350415..3351788) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /label="ywtG gene" downshifts complement(3350420) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" /label="downshifts" S_feature complement(3351789..3351852) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3351840..3351858) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3351853) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3351873..3351879) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3351939..3351948 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3351960..3351975 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3351962..3352082 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3351962 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3352057..3352064 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3352078..3352097 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3352084 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3352121..3353089 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" /label="tagT CDS" gene 3352121..3353089 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /label="tagT gene" downshifts 3353074 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" /label="downshifts" promotor_-35 3353133..3353140 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3353155..3353174 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3353162..3353244 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3353162 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3353245..3354105 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" /label="ribZB CDS" gene 3353245..3354105 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /label="ribZB gene" downshifts 3354086 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3354139..3355380) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3354139..3355380) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3354158) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3355402..3355420) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3355424) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3355433..3355440) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3355521..3355688) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3355521..3355688) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3355548) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3355703..3356845) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3355703..3356845) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3356864..3357313) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3356864..3357313) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3357007..3357013 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3357021 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3357027..3357045 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3357034..3359243 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3357328..3358509) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3357328..3358509) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3359223..3359230 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3359245 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3359246..3359265 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359266) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3359271..3359285) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3359293..3359297) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3359293..3360273 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3359293..3360273 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3360122..3360129 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3360143..3360162 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3360158 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3360275..3361156 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3360275..3361156 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3361153..3361548 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3361153..3361548 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3361564..3363045 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3361564..3363045 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3363047..3364015 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3363047..3364015 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3364027..3364944 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3364027..3364944 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3364953..3364959 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3364974..3364992 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3364976 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3365026..3365562 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3365026..3365562 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3365545 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3365590..3365700 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3365669..3365675 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3365690..3365701 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3365702 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3365718..3366014 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3365718..3366014 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3366015..3366667 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3366054..3366581) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3366054..3366581) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3366064) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3366601..3366620) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366614) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3366625 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3366634..3366641) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3366680) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3366681..3367448) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3366681..3367448) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3367510..3369222) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3367510..3369222) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3368121..3368130 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3368144..3368163 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3368144 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3369276..3369295) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369281) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3369301..3369308 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3369310..3369314) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3369322..3369341 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3369332 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3369380..3370288 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3369380..3370288 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3370356..3370364 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3370366..3370498 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3370366 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3370378..3370397 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3370499..3371827 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3370499..3371827 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3371818 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3371884..3372561) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3371884..3372561) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3371894) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3372621..3373763) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3372621..3373763) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3373800..3373819) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3373808) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3373810..3373890) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3373833..3373841) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3373891..3374979) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3373891..3374979) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3374980..3375093) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3375035..3375044 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3375057..3375076 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3375070 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3375093) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3375097..3375111) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3375120..3375124) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3375120..3375707 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3375120..3375707 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3375208..3375687 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3375208..3375687 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3375591..3375788) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3375624 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3375634) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3375693 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3375772 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3375787..3375806) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375793) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3375815..3375822 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3375819..3375828) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3375837..3375856 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3375843 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3375881..3376498 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3375881..3376498 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3376499..3376599 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3376556 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3376625..3376634 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3376646..3376661 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3376647 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3376676..3377011 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3376676..3377011 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3376967..3376985) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3376976) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3377000..3377005) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3377010 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3377016..3378593) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3377016..3378593) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3377055..3378766 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3378744..3378751 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3378762..3378781 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3378768 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3378807..3379283 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3378807..3379283 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3379297..3379890 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3379297..3379890 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3379887..3380423 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3379887..3380423 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3380404 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3380450..3380671) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3380450..3380671) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3380618 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3380625..3380626 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3380668..3381213) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3380668..3381213) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3381230..3381237 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3381252..3381271 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3381256 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3381336..3382217 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3381336..3382217 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3382302..3383018) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3382302..3383018) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3382322) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3383028..3383492) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3383028..3383492) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3383482..3385290) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3383482..3385290) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3385309..3385569) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3385309..3385569) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3385579..3386001) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3385579..3386001) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3386002..3386084) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3386076..3386095) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3386084) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3386108..3386115) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3386218..3386343) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3386218..3386343) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3386261..3386392) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3386304) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3386393..3387178) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3386393..3387178) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3387179..3387294) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3387287..3387306) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387294) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3387320..3387327) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3387370..3388692) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3387370..3388692) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3387382) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3388726) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3388728..3388853) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3388728..3388746) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3388762..3388767) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3388833..3388852) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3388853) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3388887..3389651) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3388887..3389651) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3389670) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3389704..3390417) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3389704..3390417) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3389721) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3390407..3391153) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3390407..3391153) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3391185..3391204) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391197) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3391221..3391224) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3391387..3391530) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3391387..3391530) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3391408) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3391531..3391616) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3391606..3391617) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3391616) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3391618..3391848) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3391655..3391659 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3391675..3391694 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3391684 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3391734..3393344 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3391734..3393344 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3391836..3391854) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391848) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3391850..3392024) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3391868..3391875) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3392011..3392030) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3392024) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3392044..3392052) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3393331..3396099 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3393331..3396099 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3396148) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3396225..3397082) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3396225..3397082) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3397088..3397864) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3397088..3397864) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3397890..3397909) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3397912) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3397914..3397986) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3397924..3397931) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3397988..3398087) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3398031) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3398088..3398429) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3398088..3398429) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3398451..3398470) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3398470) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3398484..3398491) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3398506..3398889) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3398506..3398889) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3398911..3398930) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3398918..3398937 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3398922 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3398931) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3398945..3398952) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3399012..3399031 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3399015 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3399064) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3399064..3399474 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3399064..3399474 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3399475..3399558 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3399516 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3399614..3399922) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3399614..3399922) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3399615) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3400266..3401102 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3400266..3401102 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3400482..3400489 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3400504..3400523 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3400507 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3401101 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3401149..3401541) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3401149..3401541) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3401155) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3401614..3402039) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3401614..3402039) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3402100..3402119) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3402116) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3402118..3402202) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3402134..3402141) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3402181 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3402184..3402203 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3402194..3402213) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3402202) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3402204..3403288) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3402227..3402232) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3402231..3403295 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3402231..3403295 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3403296..3404180 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3403318..3404127) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3403318..3404127) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3403333) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3404161..3404973) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3404161..3404973) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3404974..3405053) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3405004..3405011 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3405025..3405044 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3405034 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3405047..3405065) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3405053) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3405079..3405086) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3405136..3406137) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3405136..3406137) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3405142) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3406192..3406211) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3406216) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3406218..3406302) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3406303..3406584) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3406303..3406584) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3406599..3406709) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3406599..3406709) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3406740..3406758) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3406762) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3406774..3406779) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3406855..3406861 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3406875..3406894 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3406891 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3406934..3407347 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3406934..3407347 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3407369..3408559 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3407369..3408559 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3408650..3410056) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3408650..3410056) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3408947) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3410089..3410108) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410107) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3410123..3410126) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3410162..3411634) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3410162..3411634) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3411815..3413173) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3411815..3413173) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3411829) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3413173..3413742) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3413173..3413742) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3413761..3413772) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413779) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3413786..3413792) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3413849..3414016) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3413849..3414016) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3413926..3414390) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3413926..3414390) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3414420..3414439) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3414425) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3414453..3414460) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3414591..3414594 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3414609..3414628 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3414613 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3414672..3415886 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3414672..3415886 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3415502..3415520) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415503) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3415534..3415541) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3415752..3415758 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3415772..3415791 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3415774 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3415898..3416248 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3415898..3416248 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3416241 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3416300..3416308 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3416322..3416330 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3416329 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3416371..3416380 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3416393..3416408 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3416397 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3416429..3417010 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3416429..3417010 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3416527..3416546) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3416537) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3416560..3416568) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3416991 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3417051..3417473) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3417051..3417473) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3417070) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3417508..3417523) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3417527) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3417536..3417545) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3417584..3418435) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3417584..3418435) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3417593) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3417835) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3418072..3418074 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3418091..3418110 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3418092..3418438 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3418092 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3418430..3418433 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3418440..3418575 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3418440 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3418469) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3418475..3418484) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3418576..3419067 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3418576..3419067 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3418805..3418810 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3418826..3418844 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3418837 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3418928..3419836) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3419064..3419582 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3419064..3419582 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3419387 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3419585 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3419741..3419872 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3419741..3419872 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3419869..3420303) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3419869..3420303) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3419881) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3420352..3420371) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3420359) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3420361..3420658) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3420386..3420393) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3420432..3420436 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3420453..3420472 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3420465..3420545 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3420466 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3420546..3421994 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3420546..3421994 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3420658) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3420659..3420677) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3420660..3421003) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3420693..3420699) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3420981..3420999) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421003) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3421015..3421020) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3421983 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3422015..3422788) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3422015..3422788) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3422037) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3422863..3422866 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3422882..3422901 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3422886 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3422933..3423316 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3422933..3423316 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3423303 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3423351..3423992) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3423351..3423992) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3423401) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3424060..3424461) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3424060..3424461) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3424510..3424529) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3424520) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3424522..3424595) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3424544..3424549) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3424596..3426305) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3424596..3426305) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3426302..3426676) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3426302..3426676) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3426673..3426990) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3426673..3426990) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3426991..3427075) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3427075) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3427077..3427090) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3427077..3427170) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3427171..3427335) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3427171..3427335) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3427258..3427276) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3427270) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3427288..3427296) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3427336..3427507) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3427508..3427690) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3427508..3427690) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3427691..3427837) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3427825..3427844) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3427837) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3427839..3427953) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3427859..3427866) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3427940,3427942) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3427967 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3427970..3427974 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3427987..3428175) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3427987..3428175) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3427998) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3428165 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3428201..3428219) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3428212) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3428233..3428239) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3428248..3428748) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3428248..3428748) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3428784..3428803) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3428791) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3428817..3428823) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3428883..3430016) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3428883..3430016) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3428901) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3430043..3430062) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3430050) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3430113..3430131) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430129) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3430145..3430152) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3430208..3431233) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3430208..3431233) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3430221) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3431249..3432037) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3431249..3432037) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3432063..3432082) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3432069) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3432071..3432282) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3432096..3432103) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3432283..3432444) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3432283..3432444) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3432457..3432475) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3432477) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3432489..3432495) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3432538..3433212) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3432538..3433212) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3432553) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3433265..3433405) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3433265..3433405) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3433536..3434219) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3433536..3434219) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3434596..3434600 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3434605..3435636) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3434605..3435636) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3434615..3434634 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3434621) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3434633 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3435664..3435682) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435677) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3435679..3435796) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3435698..3435703) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3435738..3435743 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3435755..3438415 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3435755 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3435759..3435777 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3435832..3437142) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3435832..3437142) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3435841) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3437166..3437185) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3437173) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3437176..3437916) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3437176..3437916) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3437199..3437208) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3437547) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3437549..3437557) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3437571..3437579) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3437671..3437686) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3437679) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3437699..3437708) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3437917..3438044) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3438045..3438275) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3438045..3438275) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3438276..3438538) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3438411..3438430 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3438417 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3438445..3438918 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3438445..3438918 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3438522..3438541) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3438538) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3438540..3438923) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3438556..3438559) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3438952..3439350) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3438952..3439350) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3438968) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3439342..3439360) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439351) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3439374..3439380) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3439374..3440795) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3439374..3440795) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3440821..3441684) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3440821..3441684) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3441685..3441760) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3441761..3443269) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3441761..3443269) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3443286..3443831) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3443286..3443831) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3443828..3444340) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3443828..3444340) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3444341..3444502) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3444503..3444715) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3444503..3444715) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3444761..3445495) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3444761..3445495) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3445309..3445409 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3445369 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3445503..3445886) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3445503..3445886) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3445575..3445593) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3445577) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3445887..3446157) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3446119..3446128 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3446128 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3446133..3446152) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3446142..3446161 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446157) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3446159..3446280) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3446165..3446172) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3446309..3446938) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3446309..3446938) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3446325) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3446982..3447001) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3447005) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3447016..3447023) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3447073..3448320) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3447073..3448320) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3447096) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3448362..3448381) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3448379) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3448381..3448465) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3448396..3448401) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3448510) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3448527..3449069) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3448527..3449069) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3449082..3449531) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3449082..3449531) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3449532..3449631) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3449623..3449642) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3449631) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3449656..3449663) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3449688..3450140) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3449688..3450140) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3450157..3450176) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3450175) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3450191..3450194) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3450216..3450773) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3450216..3450773) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3450800..3450818) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3450813) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3450834..3450839) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3450852..3451892) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3450852..3451892) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3450857) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3451893..3451957) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3451947..3451966) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3451957) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3451959..3452048) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3451982..3451986) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3452049..3452492) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3452049..3452492) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3452559..3453233) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3452559..3453233) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3452995..3453013) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3453002) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3453028..3453034) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3453265..3453282) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3453266) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3453298..3453303) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3453339 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3453343..3453362 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3453374..3453736 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3453374..3453736 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3453749) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3453753..3454040) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3453753..3454040) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3454041..3454099) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3454097..3454116) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3454100..3454966) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3454100..3454966) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3454113) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3454129..3454138) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3454968..3456038) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3454968..3456038) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3454971) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3456039 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3456066..3456085) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456090) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3456092..3456203) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3456099..3456105) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3456135..3456154 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3456149 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3456164..3456550 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3456164..3456550 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3456185..3456203) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3456203) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3456217..3456224) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3456618..3456626 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456637..3456655 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3456638 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3456672..3457226 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3456672..3457226 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3457156..3457160 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3457161 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3457205 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3457260..3458219) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3457260..3458219) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3457282) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3458257..3458275) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3458271) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3458290..3458296) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3458301..3460049) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3458301..3460049) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3458775..3458793) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3458783) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3458808..3458814) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3460050..3460140) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3460124..3460143) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3460140) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3460157..3460164) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3460283) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3460288..3460875) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3460288..3460875) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3460964..3461164) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3460964..3461164) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3460977) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3461165..3461242) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3461238..3461257) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461242) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3461271..3461278) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3461283..3462566) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3461283..3462566) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3462567..3462869) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3462597..3462758) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3462597..3462758) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3462849..3462868) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3462869) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3462884..3462888) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3462973..3463938) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3462973..3463938) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3462979) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3463555..3463564 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3463577..3463596 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3463585 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3463969..3465258) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3463969..3465258) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3465259..3465618) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3465637..3466275) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3465637..3466275) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3465663) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3466276..3466394) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3466395..3467252) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3466395..3467252) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3467253..3467379) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3467361..3467380) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3467379) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3467394..3467401) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3467433..3467807) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3467433..3467807) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3467847..3467865) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3467861) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3467863..3468502) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3467864..3467867 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3467876..3467884) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3467883..3467902 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3467896 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3467910..3467915 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3467931..3467950 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3467941 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3467973..3468494 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3467973..3468494 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3468437..3468440 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3468455..3468474 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3468469 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3468492..3468511) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3468502) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3468513 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3468526..3468533) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3468576..3470183) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3468576..3470183) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3468589) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3470184..3470371) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3470359..3470378) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3470371) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3470393..3470400) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3470425..3470946) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3470425..3470946) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3470481) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3470947..3471049) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3471030..3471049) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3471049) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3471051..3471128) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3471065..3471068) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3471129..3472268) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3471129..3472268) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3472265..3474382) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3472265..3474382) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3474383..3474441) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3474442..3474461) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474455) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3474475..3474482) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3474481..3474487 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3474501..3474512 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3474506 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3474537..3475733 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3474537..3475733 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3474729..3475607) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3475597..3475615) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3475608) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3475631..3475636) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3475746..3476708 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3475746..3476708 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3476722..3476728 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3476743..3476761 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3476743 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3476789..3477061 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3476789..3477061 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3476795) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3477051 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3477096..3477502 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3477103..3477627) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3477103..3477627) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3477125) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3477637..3479364) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3477637..3479364) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3479398..3479417) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3479412) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3479431..3479437) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3479453..3480955) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3479453..3480955) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3480979..3480997) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3480997) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3481012..3481018) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3481042..3481414) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3481085) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3481441..3482112) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3481441..3482112) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3481459) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3482109..3482663) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3482109..3482663) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3482689..3484152) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3482689..3484152) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3484142..3487828) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3484142..3487828) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3487859..3487878) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3487883) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3487885..3488014) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3488024..3488500) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3488024..3488500) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3488059) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3488523..3488542) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3488535) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3488557..3488560) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3488607 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3488610..3488629 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3488644..3489363 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3488644..3489363 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3489347 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3489395..3490111) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3489395..3490111) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3489397) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3489467) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3490137..3490156) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3490149) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3490210..3491397) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3490210..3491397) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3491427..3491446) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3491445) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3491533..3493203) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3491533..3493203) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3491535) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3493200..3493628) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3493200..3493628) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3493696..3493710 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3493696..3493715) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3493703 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3493712) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3493732..3493735) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3493767..3493786) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3493779) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" promotor_-35 3493859..3493866 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3493874 /Source="Nicolas_upshifts" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3493879..3493898 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3493923 /Source="Nicolas_upshifts" /id="D1933" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="8.77621" /MaxDrop="1.77243" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4576 /isTUend="FALSE" /label="downshifts" CDS 3493941..3494072 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12696888, 15743949, 16095584, 17213266, 27914001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12696888, 15743949, 16095584, 17213266, 27914001; Product type f: factor" /codon_start=1 /transl_table=11 /product="subtilosin A" /protein_id="NP_391616.1" /db_xref="EnsemblGenomes-Gn:BSU37350" /db_xref="EnsemblGenomes-Tr:CAB15763" /db_xref="GOA:O07623" /db_xref="InterPro:IPR021539" /db_xref="PDB:1PXQ" /db_xref="SubtiList:BG12671" /db_xref="UniProtKB/Swiss-Prot:O07623" /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG* " /label="sboA CDS" gene 3493941..3494072 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /label="sboA gene" CDS 3494029..3494181 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin-like product" /protein_id="YP_054594.1" /db_xref="EnsemblGenomes-Gn:BSU37360" /db_xref="EnsemblGenomes-Tr:CAE01468" /db_xref="SubtiList:BG14182" /db_xref="UniProtKB/Swiss-Prot:Q7WY57" /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIH TQPFFI*" /label="sboX CDS" gene 3494029..3494181 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /label="sboX gene" downshifts 3494061 /Source="Nicolas_upshifts" /id="D1934" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="8.85351" /MaxDrop="5.1396" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4714 /isTUend="FALSE" /label="downshifts" promotor_-35 3494176..3494182 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3494197..3494216 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3494200 /Source="Nicolas_upshifts" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="upshifts" CDS 3494206..3495552 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /EC_number="1.21.98.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066831, 15743949, 22366720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066831, 15743949, 22366720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subtilosin A thioether formation enzyme" /protein_id="NP_391617.1" /db_xref="EnsemblGenomes-Gn:BSU37370" /db_xref="EnsemblGenomes-Tr:CAB15764" /db_xref="GOA:P71011" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR008792" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017200" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12471" /db_xref="UniProtKB/Swiss-Prot:P71011" /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDL NKTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRA SRHTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADML FDNGVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQK IIVGISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHD MAQKVRDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPII PYERKRAANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLW QAQAPRFSEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI*" /label="albA CDS" gene 3494206..3495552 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /label="albA gene" CDS 3495565..3495726 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809709, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809709, 15743949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane component involved in subtilosin production" /protein_id="NP_391618.1" /db_xref="EnsemblGenomes-Gn:BSU37380" /db_xref="EnsemblGenomes-Tr:CAB15765" /db_xref="GOA:P71010" /db_xref="SubtiList:BG12470" /db_xref="UniProtKB/Swiss-Prot:P71010" /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFG MRARKADSR*" /label="albB CDS" gene 3495565..3495726 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /label="albB gene" CDS 3495723..3496442 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /function="16.5: Explore" /function="16.6: Maintain" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter involved in subtilosin production" /protein_id="NP_391619.1" /db_xref="EnsemblGenomes-Gn:BSU37390" /db_xref="EnsemblGenomes-Tr:CAB15766" /db_xref="GOA:P71009" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12469" /db_xref="UniProtKB/Swiss-Prot:P71009" /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKT TLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDY VSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLF ILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQK VIPIGEETDLRREFFEVIGHE*" /label="albC CDS" gene 3495723..3496442 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /label="albC gene" CDS 3496435..3497745 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949, 15849754, 16850406, 18034824; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral membrane protein involved in subtilosinproduction and immunity" /protein_id="NP_391620.1" /db_xref="EnsemblGenomes-Gn:BSU37400" /db_xref="EnsemblGenomes-Tr:CAB15767" /db_xref="GOA:P71008" /db_xref="SubtiList:BG12468" /db_xref="UniProtKB/Swiss-Prot:P71008" /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQ AGIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVV LFVDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVK KKNLMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHS FMRRSEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISA LLLICSPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFI SGRSISVLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPL FLAILAGTAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS*" /label="albD CDS" gene 3496435..3497745 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /label="albD gene" CDS 3497735..3498895 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /function="16.8: Protect" /function="16.5: Explore" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase involved in subtilosin A production" /protein_id="NP_391621.1" /db_xref="EnsemblGenomes-Gn:BSU37410" /db_xref="EnsemblGenomes-Tr:CAB15768" /db_xref="GOA:P71007" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG12467" /db_xref="UniProtKB/Swiss-Prot:P71007" /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYL KEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSF PSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKA IHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFET ETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHV ITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQF DSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG*" /label="albE CDS" gene 3497735..3498895 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /label="albE gene" CDS 3498900..3500180 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949, 25817994; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase involved in subtilosin production" /protein_id="NP_391622.1" /db_xref="EnsemblGenomes-Gn:BSU37420" /db_xref="EnsemblGenomes-Tr:CAB15769" /db_xref="GOA:P71006" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG12466" /db_xref="UniProtKB/Swiss-Prot:P71006" /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDF GSRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNF MFTSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLIS MLSPSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPH LQLEKRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKL YWDIAARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYID VASYYVTQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHI IQDMDAQVFLSLIDAMASSNKAIIHVSQKEAIRQ*" /label="albF CDS" gene 3498900..3500180 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /label="albF gene" CDS 3500177..3500878 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein involved in subtilosin production and immunity" /protein_id="NP_391623.1" /db_xref="EnsemblGenomes-Gn:BSU37430" /db_xref="EnsemblGenomes-Tr:CAB15770" /db_xref="GOA:P71005" /db_xref="SubtiList:BG12465" /db_xref="UniProtKB/Swiss-Prot:P71005" /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVR LGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAED VKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILY LLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSF IYKRFSYHSTASLDL*" /label="albG CDS" gene 3500177..3500878 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /label="albG gene" downshifts complement(3500445) /Source="Nicolas_upshifts" /id="D1935" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="0.362109999999999" /MaxDrop="3.55474" /score="6.50386958" /energy="-12" /TU="NA" /idTUdmin="U2945" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3500534..3500883) /Source="Nicolas_S_feature" /locus_tag="new_3842651_3843000_c" /HighExp="BT, B36, B60, Pyr, G/S, Mal, S3, G135, M/G, Sw" /AntisenseName="albG" /AntisenseCor="2.0087959212361201E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1449" downshifts complement(3500577) /Source="Nicolas_upshifts" /id="D1936" /incds=1 /nref=6 /ntot=18 /MaxReadThrough="3.01883" /MaxDrop="4.2137" /score="6.50386958" /energy="-12" /TU="U2945" /idTUdmin="U2945" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 3500879..3503361 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3500884..3502260) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3500884..3502260) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3502299..3503654) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3502299..3503654) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3503690..3503709) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3503708) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3503722..3503731) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3503834..3503853 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3503835 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3503880) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3503884..3505029 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3503884..3505029 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3504888..3504892 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3504909..3504928 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3504916 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3504999) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3505013..3505132 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3505013..3505132 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3505117 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3505162..3505230 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3505231..3505704 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3505231..3505704 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3505693 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3505736..3506608) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3505736..3506608) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3505747) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3505813) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3506669..3507499) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3506669..3507499) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3507500..3507595) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3507583..3507602) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3507594) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3507615..3507622) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3507640..3507645 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3507661..3507679 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3507663 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3507701..3509776 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3507701..3509776 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3509829) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3509953..3510068) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3509996) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3510069..3510587) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3510069..3510587) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3510601..3511260) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3510601..3511260) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3511283..3511286 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3511296..3511315) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3511301..3511320 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3511304 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3511314) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3511316..3511599) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3511330..3511337) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3511369..3511557 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3511369..3511557 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3511546 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3511600..3512019) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3511600..3512019) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3512069..3512088) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3512080) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3512103..3512110) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3512139..3514055) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3512139..3514055) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3513333..3513351) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3513338) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3513368..3513372) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3514086) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3514109..3514330) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3514109..3514330) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3514362..3514583) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3514362..3514583) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3514615..3514877) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3514626 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3514658) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3514665..3514820) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3514665..3514820) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3514827..3514830 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3514839..3514852 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3514846 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3514854..3514873) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3514877) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3514887..3514893) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3514900..3516300) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3514900..3516300) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3516300..3516770) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3516300..3516770) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3516726) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3516882..3517382) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3516882..3517382) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3516885) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3517418..3518719) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3517418..3518719) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3518743..3518762) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3518757) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3518759..3518880) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3518778..3518780) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3518881..3519105) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3518881..3519105) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3519106..3519190) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3519179..3519198) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3519189) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3519213..3519216) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3519256..3519262 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3519277..3519288 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3519278 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3519320..3520096 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3519320..3520096 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3520082 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3520184..3520191 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3520206..3520225 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3520210..3524436 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3520210 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3520240..3521130) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3520240..3521130) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3521130..3521230) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3521170) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3521298..3522143) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3521298..3522143) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3521461) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3522192..3523091) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3522192..3523091) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3523134..3523153) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3523137) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3523167..3523174) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3523238) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3523238..3524209) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3523238..3524209) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3524244..3524263) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3524269) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3524279..3524283) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3524357..3524368) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3524360) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3524382..3524388) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3524431..3524450 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3524438 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3524479..3525243 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3524479..3525243 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3525230 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3525306..3525312 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3525326..3525345 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3525335 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3525376..3526155 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" /label="bacG CDS" gene 3525376..3526155 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /label="bacG gene" downshifts 3526132 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3526170..3527369) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" /label="bacF CDS" gene complement(3526170..3527369) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /label="bacF gene" CDS complement(3527370..3528554) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" /label="bacE CDS" gene complement(3527370..3528554) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /label="bacE gene" CDS complement(3528551..3529969) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" /label="bacD CDS" gene complement(3528551..3529969) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /label="bacD gene" CDS complement(3529988..3530749) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" /label="bacC CDS" gene complement(3529988..3530749) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /label="bacC gene" CDS complement(3530752..3531459) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" /label="bacB CDS" gene complement(3530752..3531459) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /label="bacB gene" misc_feature complement(3531355..3531356) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3531356) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3531449..3532063) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" /label="bacA CDS" gene complement(3531449..3532063) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /label="bacA gene" promotor_-35 3531621..3531627 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3531643..3531661 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3531654..3532265 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3531654 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3532086..3532105) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3532102) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3532120..3532127) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3532214) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" /label="downshifts" CDS complement(3532215..3533453) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3532215..3533453) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3533495..3533514) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3533507) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3533526..3533533) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3533663..3535075) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3533663..3535075) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3533670) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3535075..3536775) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3535075..3536775) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3535744..3535760) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3535756) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3536849..3538396) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3536849..3538396) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3536856) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3538440) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3538442..3538622) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3538443..3538461) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3538623..3539897) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3538623..3539897) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3539898..3539980) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3539980) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3539993..3540011) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3540073) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3540074..3540538) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3540074..3540538) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3540539..3540649) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3540631..3540650) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3540649) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3540665..3540672) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3540860) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3540862..3541317) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3540862..3541317) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3540952..3540971 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3540960 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3541310..3542161) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3541310..3542161) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3542175..3543122) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3542175..3543122) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3543122..3543862) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3543122..3543862) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3543880..3543885 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3543886 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3543887..3544906) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3543887..3544906) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3543900..3543918 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3544770..3544779 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3544792..3544807 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3544803 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3544909..3545631) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3544909..3545631) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3545624..3546745) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3545624..3546745) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3546745..3547614) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3546745..3547614) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3547615..3548784) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3547615..3548784) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3548805..3550229) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3548805..3550229) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3550234..3551004) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3550234..3551004) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3551039..3551058) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3551053) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3551072..3551081) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3551172..3551177 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3551193..3551211 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3551195..3551323 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3551195 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3551324..3551869 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3551324..3551869 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3551855 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3551913..3552284) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3551913..3552284) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3551931) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3552346..3553668) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3552346..3553668) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3553688..3554005) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3553688..3554005) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3554034..3554053) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3554045) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3554067..3554073) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3554108..3554115 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3554131..3554150 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3554134 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3554173..3555543 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3554173..3555543 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3555568..3556245) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3555568..3556245) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3555582) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3556072..3556091) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3556088) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3556107..3556112) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3556259..3557065) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3556259..3557065) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3556558..3556576) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3556572) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3556591..3556597) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3557094..3557113) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3557100) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3557129..3557136) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3557155..3557688) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3557155..3557688) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3557736..3558371) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3557736..3558371) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3558364..3558702) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3558364..3558702) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3558724..3558743) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3558735) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3558758..3558765) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3558786..3558789 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3558804..3558823 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3558804 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3558846..3559661 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3558846..3559661 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3559640 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3559716) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3559751..3559999) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3559751..3559999) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3559771) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3560017) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3560019..3560092) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3560027..3560033) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3560093..3561532) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3560093..3561532) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3561529..3562914) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3561529..3562914) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3562933..3562942) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3562947) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3562949..3563013) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3562992..3563009) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3563013) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3563025..3563032) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3563055..3563074) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3563073) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3563088..3563095) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3563154..3563157 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3563164 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3563172..3563191 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3563216..3563986 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3563216..3563986 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3563987..3565054 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3564025..3564855) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3564025..3564855) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3564026) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3564881..3564900) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3564887) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3564895..3565197) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3564895..3565197) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3564915..3564922) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3565198..3565336) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3565321..3565340) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3565336) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3565651..3565659 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3565670..3565688 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3565671 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3565727..3568147 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3565727..3568147 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3565885 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3565894..3565913 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3568135 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3568185..3569186) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3568185..3569186) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3569187..3569348) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3569360..3570109) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3569360..3570109) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3569393) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3570127..3570146) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3570144) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3570161..3570164) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3570215..3571396) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3570215..3571396) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3570229) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3571397..3571528) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3571522..3571537) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3571528) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3571549..3571558) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3571763..3571770 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3571781..3571891 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3571781..3571800 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3571781 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3571892..3572155 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3571892..3572155 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3572045 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3572161 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3572198..3572572) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3572198..3572572) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3572209) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3572574..3573188) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3572574..3573188) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3573202..3575151) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3573202..3575151) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3574415..3574434 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3574421 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3574845..3574945 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3574905 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3575015 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3575179..3576144) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3575179..3576144) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3576145..3576213) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3576200..3576219) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3576213) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3576215..3576400) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3576232..3576236) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3576331..3576336 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3576352..3576370 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3576357 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3576391..3576410) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3576400) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3576402..3576511) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3576425..3576429) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3576467 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3576496..3576515) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3576511) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3576531..3576535) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3576589..3576607) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3576594..3576600 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3576606) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3576615..3576633 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3576618 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3576623..3576628) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3576660..3576905 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3576660..3576905 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3576887 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3576976..3578517) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3576976..3578517) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3577005) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3578521..3579693) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3578521..3579693) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3579711..3579729) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3579733) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3579744..3579750) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3579774..3580157) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3579774..3580157) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3580175..3580846) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3580175..3580846) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3580868..3580887) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3580877) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3580903..3580906) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3580987..3580990 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3581005..3581024 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3581014..3581201 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3581014 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3581202..3581360 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3581202..3581360 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3581361..3581745 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3581726..3581731 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3581747..3581765 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3581747 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3581803..3582111 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3581803..3582111 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3581889) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3581893..3581993) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3581933) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3582108..3583649 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3582108..3583649 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3583640 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3583680..3584282) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3583680..3584282) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3583694) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3584283..3584564) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3584565..3585815) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3584565..3585815) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3584661) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3585834..3586991) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3585834..3586991) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3585907..3585926) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3585934) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3586988..3588433) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3586988..3588433) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3588467..3588486) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3588477) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3588500..3588507) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3588590..3589258) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3588590..3589258) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3588599) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3589255..3590073) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3589255..3590073) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3590081..3590986) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3590081..3590986) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3590721..3590740) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3590732) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3591027..3591046) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3591037..3591044 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3591048) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3591056 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3591058..3591077 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3591062..3591069) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3591092..3591478 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3591092..3591478 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3591460..3592137 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3591460..3592137 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3592109 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3592181..3592188 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3592199 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3592202..3592221 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3592241..3593440 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3592241..3593440 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3593474..3593671 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3593474..3593671 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3593650 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3593706..3594896) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3593706..3594896) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3593721) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3593805) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3594920..3594939) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3594936) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3594956..3594963 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3594972 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3594977..3594996 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3595017..3595397 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3595017..3595397 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3595295 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3595366 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3595435..3596112) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3595435..3596112) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3595442) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3596121..3596140) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3596146) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3596152..3596158) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3596189..3597523) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3596189..3597523) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3597571..3597589) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3597594) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3597688..3597695 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3597700 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3597709..3597727 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3597751..3599688 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3597751..3599688 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3598895..3598914) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3598896) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3598928..3598936) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3599678 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3599791..3599798 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3599813..3599832 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3599832 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3600044..3600051 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3600064..3600083 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3600064 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3600116..3601495 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3600116..3601495 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3601204..3602407) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3601549..3602391 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3601549..3602391 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3602442..3603302) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3602442..3603302) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3602452) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3603286 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3603324..3603342) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3603342) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3603357..3603363) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3603412..3604125) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3603412..3604125) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3603527..3603528 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3603548..3603565 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3603550 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3604153..3604164) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3604154) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3604179..3604185) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3604200..3604206 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3604221..3604240 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3604231 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3604276..3604791 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3604276..3604791 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3604792..3604998 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3604792..3604998 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3604958 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3605040..3606281 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3605040..3606281 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3606372..3606380 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3606391..3606409 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3606402 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3606437..3607804 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3606437..3607804 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3607781 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3607834..3608466) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3607834..3608466) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3607852) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3608502..3608517) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3608510) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3608530..3608538) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3608608..3609543) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3608608..3609543) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3608620) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3609287..3609296 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3609310..3609329 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3609314 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3609544..3609631) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3609614..3609633) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3609631) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3609649..3609653) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3609676..3609688) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3609676) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3609703..3609709) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3609706..3609840) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3609706..3609840) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3609787..3609794 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3609808..3609827 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3609817 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3609820..3609924 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3609919..3609928 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3609926 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3609940..3609955 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3609962) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3609964..3609978) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3609990..3610139 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3609990..3610139 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3610157..3611668 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3610157..3611668 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3611665..3612852 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3611665..3612852 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3612869..3613105 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3612869..3613105 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3613105..3614283 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3613105..3614283 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3614284..3614373 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3614374..3615132 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3614374..3615132 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3615100 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3615134..3616361) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3615180..3615187 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3615201..3615220 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3615214 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3615273..3616364 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3615273..3616364 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3616266 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3616354 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3616398..3617726) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3616398..3617726) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3616406) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3617723..3618055) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3617723..3618055) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3618074..3619432) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3618074..3619432) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3619448..3619756) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3619448..3619756) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3619801..3619820) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3619817) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3619834..3619840) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3619885) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3619885..3621810) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3619885..3621810) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3620548..3620557 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3620571..3620590 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3620579 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3621883..3621900) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3621907) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3621915..3621922) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3621973..3622131) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3621973..3622131) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3622000) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3622160..3622750) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3622160..3622750) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3622778..3622796) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3622789) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3622810..3622816) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3622819..3622825 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3622841..3622859 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3622844 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3622879..3624522 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3622879..3624522 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3623016..3624565) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3624517 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3624567..3624658) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3624569..3624575 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3624583 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3624590..3624609 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3624610) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3624627..3625829 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3624627..3625829 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3624660..3625825) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3624703) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3625826..3626602) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3625826..3626602) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3626599..3627486) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3626599..3627486) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3627493..3627681) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3627493..3627681) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3627678..3627884) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3627678..3627884) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3627881..3628201) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3627881..3628201) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3628014..3628023 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3628036..3628055 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3628038 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3628194..3628730) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3628194..3628730) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3628758) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3628759..3628774) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3628786..3628795) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3628861..3628868 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3628882..3628901 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3628891 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3628942..3630315 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3628942..3630315 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3629222..3629764) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3629752..3629771) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3629764) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3629786..3629793) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3630150 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3630330..3631160) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3630330..3631160) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3630336) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3631179..3631197) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3631194) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3631212..3631218) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3631238) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3631240..3631259) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3631246..3632973) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3631246..3632973) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3631345) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3632970..3634673) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3632970..3634673) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3634673..3635689) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3634673..3635689) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3635563..3635581) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3635572) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3635597..3635602) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3635673..3637079) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3635673..3637079) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3637080..3637288) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3637271..3637290) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3637288) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3637290..3637398) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3637304..3637309) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3637395..3637414) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3637410) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3637428..3637435) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3637556..3637563 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3637573 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3637578..3637596 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3637635..3638987 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3637635..3638987 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3638586..3641068) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3638972 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3639063..3639082 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3639069 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3639109..3640797 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3639109..3640797 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3640795..3640804 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3640816..3640831 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3640820 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3640855..3641055 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3640855..3641055 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3641056..3642000 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3641069..3641908) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3641069..3641908) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3641934..3641952) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3641952) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3641965..3641972) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3641967 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3642015..3643112) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3642015..3643112) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3642016) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3643145..3643164) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3643162) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3643164..3643232) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3643177..3643184) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3643233..3644126) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3643233..3644126) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3644153..3644172) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3644172) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3644186..3644193) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3644200..3644205 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3644221..3644239 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3644230 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3644247..3644253 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3644268..3644286 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3644274 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3644310..3645767 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3644310..3645767 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3645193..3645211) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3645208) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3645226..3645231) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3645748 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3645792 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3645809..3646645) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3645809..3646645) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3645827) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3646722..3646824) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3646722..3646824) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3646748) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3646850..3646869) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3646861) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3646863..3647604) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3646883..3646889) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3646941..3646948 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3646961..3646979 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3646970 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3646980..3647065 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3647041..3647048 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3647062..3647081 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3647067 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3647213..3647755 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3647213..3647755 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3647580..3647599) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3647604) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3647613..3647622) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3647745 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3647790..3648112 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3647830..3648849) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3647830..3648849) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3647848) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3648875..3648894) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3648889) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3648909..3648912) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3648964..3649470) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3648964..3649470) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3649476..3649495) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3649498) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3649500..3649503 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3649509..3649515) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3649518..3649537 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3649521 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3649600..3650475 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3649600..3650475 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3649850..3649938) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3649872) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3649898..3649998) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3649938) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3650553..3651026 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3650553..3651026 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3651044..3652264 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3651044..3652264 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3652251..3652907 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3652251..3652907 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3652905..3652910 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3652924..3652943 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3652927 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3652957..3654189 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3652957..3654189 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3652974) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3654174 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3654235..3654244 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3654257..3654272 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3654259..3654481 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3654259 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3654438 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3654492..3654498 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3654511..3654611 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3654511 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3654513..3654531 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3654590..3654597 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3654611..3654629 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3654613..3654710 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3654613 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3654711..3654974 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3654711..3654974 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3654738..3654741 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3654756..3654775 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3654768 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3654922 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3654966 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3655041..3655050 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3655056 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3655062..3655077 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3655103..3655591 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3655103..3655591 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3655596..3655603 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3655617..3655636 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3655627 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3655657..3655763 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3655657..3655763 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3655758 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3655846..3656979 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3655846..3656979 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3656119..3656362) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3656357..3656376) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3656366) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3656391..3656398) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3656985..3656992 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3657007..3657026 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3657013 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3657048..3657154 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3657048..3657154 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3657101 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3657155..3657231 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3657232..3658368 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3657232..3658368 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3658355 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3658421..3659194) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3658421..3659194) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3658431) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3659211..3659861) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3659211..3659861) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3659858..3660574) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3659858..3660574) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3660598..3662016) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3660598..3662016) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3661184..3661202) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3661203) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3661218..3661223) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3662017..3662101) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3662085..3662103) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3662101) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3662119..3662124) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3662170..3663018) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3662170..3663018) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3662180) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3663019..3663204) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3663193..3663212) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3663204) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3663206..3663931) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3663228..3663232) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3663366..3663373 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3663386..3663405 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3663395 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3663405..3663507 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3663405..3663507 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3663508..3663611 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3663583..3663589 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3663603..3663614 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3663613 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3663634..3664827 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3663634..3664827 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3663918..3663936) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3663934) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3663949..3663956) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3664603 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3664823 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3664869..3665297) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3664869..3665297) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3665298..3665540) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3665298..3665540) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3665541..3665604) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3665593..3665608) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3665604) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3665620..3665629) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3665637 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3665685..3665975) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3665685..3665975) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3665691) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3666000..3666019) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3666017) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3666025..3668085) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3666025..3668085) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3666033..3666040) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3668114..3668132) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3668118) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3668147..3668153) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3668178..3668183 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3668197 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3668199..3668217 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3668211..3668285 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3668286..3669566 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3668286..3669566 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3669567..3669706 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3669663 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3669724..3670452) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3669724..3670452) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3669741) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3670483..3670502) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3670494) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3670516..3670523) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3670640..3670747) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3670683) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3670748..3671581) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3670748..3671581) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3671612..3671631) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3671631) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3671645..3671652) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3671677..3672357) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3671677..3672357) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3672404..3672423) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3672413) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3672437..3672444) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3672505..3672508 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3672523..3672542 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3672523 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3672564..3673850 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3672564..3673850 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3673295..3673313) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3673303) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3673327..3673334) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3673821 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3673869..3675308) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3673869..3675308) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3673892) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3675332..3675351) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3675349) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3675390..3676538) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3675390..3676538) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3676565..3676581) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3676581) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3676583..3676667) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3676596..3676601) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3676668..3676856) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3676668..3676856) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3676887..3677018) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3676887..3677018) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3677030..3677491) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3677030..3677491) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3677507..3677803) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3677507..3677803) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3677831..3678319) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3677831..3678319) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3678337..3678789) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3678337..3678789) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3678790..3678858) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3678859..3679188) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3678859..3679188) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3679189..3679310) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3679311..3679727) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3679311..3679727) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3679778..3680146) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3679778..3680146) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3680140..3680610) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3680140..3680610) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3680611..3680935) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3680936..3681364) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3680936..3681364) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3681426..3688430) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3681426..3688430) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3688437..3688451 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3688451 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3688461..3688480) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3688476) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3688495..3688502) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3688592..3689527) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3688592..3689527) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3688813) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3689528..3689648) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3689679..3690125) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3689679..3690125) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3689693) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3690162..3690181) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3690169) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3690195..3690202) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3690228..3691637) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3690228..3691637) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3691660..3693489) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3691660..3693489) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3693481..3693581) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3693521) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3693523..3693715) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3693696..3693715) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3693715) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3693717..3693850) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3693728..3693735) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3693872..3694180) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3693872..3694180) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3693895) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3694226..3694669) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3694226..3694669) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3694666..3696375) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3694666..3696375) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3695537..3695556) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3695545) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3696395..3696664) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3696395..3696664) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3696676..3697041) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3696676..3697041) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3697042..3697107) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3697094..3697113) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3697107) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3697128..3697131) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3697348..3698757) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3697348..3698757) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3697371) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3698758..3698867) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3698891..3699055) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3698891..3699055) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3698940..3698958) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3698955) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3698969..3698977) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3699247..3699266) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3699263) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3699279..3699286) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3699295..3699302 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3699317..3699336 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3699320 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3699374..3699820 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3699374..3699820 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3699825 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3699933..3701459 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3699933..3701459 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3701456..3703114 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3701456..3703114 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3703127..3704392 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3703127..3704392 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3704385..3705344 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3704385..3705344 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3705345..3705419 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3705420..3706847 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3705420..3706847 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3706843 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3706891..3708192) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3706891..3708192) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3706908) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3708222..3709403) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3708222..3709403) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3709404..3709483) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3709484..3710155) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3709484..3710155) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3710104..3710107 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3710122 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3710123..3710142 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3710183..3710202) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3710198) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3710216..3710223) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3710261..3711202) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3710261..3711202) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3711247..3711266) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3711253) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3711255..3711335) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3711282..3711285) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3711336..3712163) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3711336..3712163) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3712135) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3712188..3712206) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3712201) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3712220..3712226) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3712236..3713348) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3712236..3713348) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3713418..3714755) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3713418..3714755) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3714752..3715894) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3714752..3715894) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3715911..3716660) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3715911..3716660) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3716673..3717347) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3716673..3717347) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3717370..3718164) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3717370..3718164) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3717736..3717745 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3717757 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3717758..3717773 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3718189..3718686) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3718189..3718686) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3718700..3720025) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3718700..3720025) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3720102..3720121) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3720106) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3720135..3720142) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3720211..3720438) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3720211..3720438) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3720425..3721411) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3720425..3721411) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3720429) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3720562..3720571 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3720585..3720604 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3720595..3721228 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3720595 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3721466..3721485) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3721477) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3721500..3721507) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3721566..3722378) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3721566..3722378) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3722408..3722427) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3722418..3722975) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3722418..3722975) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3722431) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3722442..3722449) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3722956..3723390) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3722956..3723390) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3723415..3723424 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3723434 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3723437..3723456 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3723450) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3723451..3723862) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3723456..3723470) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3723479..3723483) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3723479..3723844 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3723479..3723844 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3723858 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3723862..3723866) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3723862) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3723864..3723950) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3723943..3723962) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3723950) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3723976..3723983) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3724023..3724029 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3724043..3724054 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3724050 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3724092..3724445 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3724092..3724445 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3724440 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3724489..3724887) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3724489..3724887) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3724497) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3724902..3724921) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3724918) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3724936..3724939) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3724975..3724982 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3724991..3725009) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3724997..3725016 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3725006 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3725006) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3725025..3725030) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3725065..3726030 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3725065..3726030 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3725458 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3725465..3725483 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3725937 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3726008 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3726053..3726849 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3726071..3726418) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3726071..3726418) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3726084) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3726432..3728300) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3726432..3728300) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3728275..3729048) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3728275..3729048) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3729192..3730169) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3729192..3730169) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3730166..3730855) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3730166..3730855) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3730882..3730901) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3730900) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3730916..3730922) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3730963..3731835) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3730963..3731835) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3730967) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3731856..3732692) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3731856..3732692) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3732693..3732777) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3732778..3733647) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3732778..3733647) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3733667..3734701) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3733667..3734701) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3734724..3736040) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3734724..3736040) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3736055..3736948) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3736055..3736948) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3736965..3738878) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3736965..3738878) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3738911..3739888) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3738911..3739888) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3739912..3740727) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3739912..3740727) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3740728..3740801) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3740802..3742265) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3740802..3742265) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3742266..3742470) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3742269..3742276 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3742292..3742311 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3742299 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3742306..3742612 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3742452..3742471) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3742470) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3742472..3742624) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3742486..3742493) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3742572..3742579 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3742594..3742613 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3742614 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3742625..3742644) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3742641) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3742660..3742667) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3742681..3743436 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3742681..3743436 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3743415..3743421 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3743436..3743455 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3743450 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3743490..3744422 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3743490..3744422 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3744424 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3744501..3744508 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3744522..3744541 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3744528..3744683 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3744528 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3744684..3745334 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3744684..3745334 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3745338..3745646 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3745338..3745646 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3745648 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3745790..3745796 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3745812..3745830 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3745822 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3745884..3747269 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3745884..3747269 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3747255 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3747300..3747850 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3747311..3749191) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3747311..3749191) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3747317) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3749192..3749289) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3749280..3749299) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3749289) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3749314..3749321) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3749359..3749610) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3749359..3749610) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3749377) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3749632..3749651) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3749641) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3749674..3749680 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3749694..3749712 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3749695 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3749727..3750548 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3749727..3750548 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3750532 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3750577..3751719) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3750577..3751719) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3750587) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3751720..3751819) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3751807..3751826) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3751818) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3751840..3751847) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3751862..3753199 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3751862..3753199 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3752604..3753204) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3753238..3753717) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3753238..3753717) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3753249) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3753797..3754789) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3753797..3754789) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3753821) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3754779 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3754812..3754831) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3754830) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3754846..3754853) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3754852..3754859 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3754873..3755297 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3754873 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3754874..3754893 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3754879..3755291 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3754879..3755291 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3754899) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3754909..3754923) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3754931..3754935) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3755263 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3755298..3756032 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3755298..3756032 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3756032..3756301 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3756032..3756301 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3756305..3756787 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3756305..3756787 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3756808..3759051 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3756808..3759051 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3759048..3760247 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3759048..3760247 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3760003..3760021) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3760025) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3760036..3760042) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3760238 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3760311) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3760311..3761543) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3760311..3761543) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3761575..3761594) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3761587) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3761608..3761613) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3761644..3762069) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3761644..3762069) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3762097..3762116) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3762111) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3762129..3762135) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3762261..3762268 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3762278 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3762283..3762302 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3762326..3762781 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3762326..3762781 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3762719 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3762782..3763395 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3762811..3764019) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3762811..3764019) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3762838) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3764020..3764126) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3764127..3765140) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3764127..3765140) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3765141..3765214) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3765199..3765218) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3765214) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3765231..3765238) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3765234..3765809) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3765234..3765809) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3765258) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3765838..3765857) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3765852) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3765872..3765879) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3765880..3765886 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3765901..3765919 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3765908 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3765940..3767010 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3765940..3767010 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3767008 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3767067..3767498) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3767067..3767498) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3767528..3767535 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3767549..3767568 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3767558..3767724 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3767558 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3767610..3767629) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3767630) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3767644..3767651) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3767725..3768129 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3767725..3768129 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3767746..3768798) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3768099..3768791 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3768099..3768791 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3768831..3769862) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3768831..3769862) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3768843) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3769829..3769832 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3769845 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3769849..3769868 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3769899..3769917) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3769917) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3769932..3769938) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3769955..3771103) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3769955..3771103) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3771142..3771161) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3771153) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3771172..3771179) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3771225..3771232 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3771246..3771265 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3771253 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3771299..3772030 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3771299..3772030 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3772023..3773564 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3772023..3773564 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3773593..3774939 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3773593..3774939 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3774392..3774396 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3774412..3774431 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3774421 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3774962..3776368 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3774962..3776368 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3776357 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3776465..3776484 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3776467..3776758 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3776467 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3776731..3776738 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3776753..3776772 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3776760 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3776782..3776789 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3776804..3776823 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3776807) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3776810..3776824) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3776819 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3776832..3776836) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3776832..3777395 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3776832..3777395 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3777409..3778938 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3777409..3778938 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3778765) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3778931 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3778964..3779047) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3779007) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3779048..3780487) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3779048..3780487) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3780501..3780731) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3780501..3780731) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3780732..3780943) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3780940..3780959) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3780945) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3780974..3780981) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3781007..3781014 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3781025..3781044 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3781040 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3781075..3781785 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3781075..3781785 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3781813..3781971 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3781813..3781971 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3782048 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3782102..3782824) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3782102..3782824) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3782114) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3782725..3782728 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3782744..3782748 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3782759 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3782845..3783474) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3782845..3783474) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3783475..3783623) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3783624..3784382) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3783624..3784382) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3784072..3784091) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3784088) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3784104..3784111) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3784363..3785322) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3784363..3785322) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3785311 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3785358..3785361 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3785366 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3785380..3785529) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3785380..3785529) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3785387) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3785438..3785455 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3785443 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3785524 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3785550..3785569) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3785571) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3785584..3785591) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3785864..3785871 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3785886..3785905 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3785890 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3786001..3787926 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3786001..3787926 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3787927..3789291 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3788139..3788459) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3788460..3790220) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3788460..3790220) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3788503) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3789288..3789289 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3789293 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3790220..3790618) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3790220..3790618) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3790611..3792056) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3790611..3792056) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3791306..3791313 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3791325..3791344 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3791335..3792384 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3791335 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3792057..3792317) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3792318..3792797) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3792318..3792797) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3792798..3792877) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3792878..3793048) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3792878..3793048) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3793089..3793108) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3793105) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3793122..3793127) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3793171..3793178 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3793191..3793210 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3793208 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3793233..3793646 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3793233..3793646 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3793626 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3793680..3794906) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3793680..3794906) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3793695) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3794929..3794947) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3794934) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3794959..3794967) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3794969..3795139) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3794969..3795139) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3795158..3795176) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3795176) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3795190..3795196) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3795244..3795492) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3795244..3795492) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3795508..3796671) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3795508..3796671) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3795542..3795560) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3795550) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3795572..3795580) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3796682..3797419) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3796682..3797419) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3797461..3797479) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3797467) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3797493..3797501) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3797561..3798031) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3797561..3798031) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3797574) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3798032..3798102) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3798063..3798069 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3798083..3798102 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3798084..3798103) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3798084 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3798102) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3798104..3798379) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3798118..3798125) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3798142..3799239 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3798142..3799239 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3798370..3798388) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3798379) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3798403..3798408) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3798963..3798971 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3798983..3799001 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3798996 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3799240..3799356 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3799240..3799356 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3799345 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3799593..3800483) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3799593..3800483) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3799599) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3799661) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3800557..3801960) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3800557..3801960) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3801961..3802182) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3802183..3803388) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3802183..3803388) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3803445..3803463) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3803448) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3803558..3803563 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3803578..3803597 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3803593 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3803629..3805014 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3803629..3805014 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3804996..3805184) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3804996..3805184) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3805301..3805429) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3805301..3805429) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3805353 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3805449..3806651) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3805449..3806651) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3805473) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3806683..3806694) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3806683) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3806709..3806715) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3806733..3807527) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3806733..3807527) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3807549..3808391) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3807549..3808391) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3808378..3809745) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3808378..3809745) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3808972,3808974) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3809735..3811570) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3809735..3811570) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3811578..3812285) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3811578..3812285) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3812286..3812382) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3812370..3812389) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3812382) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3812384..3812576) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3812405..3812408) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3812576) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3812586..3812605) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3812668) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3812669..3812741) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3812669..3812741) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3812777..3812853) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3812777..3812853) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3812854..3812934) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3812935..3813006) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3812935..3813006) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3813016..3813091) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3813016..3813091) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3813063..3813079 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3813076 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3813092..3813188) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3813172..3813191) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3813188) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3813205..3813212) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3813222..3813323) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3813262) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3813316..3814608) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3813316..3814608) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3813327) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3814648..3814667) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3814668) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3814682..3814689) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3814814..3815233) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3814814..3815233) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3815231..3815242) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3815242) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3815257..3815263) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3815354..3816718) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3815354..3816718) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3815374) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3815418) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3816749..3816768) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3816763) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3816783..3816785) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3816830..3816836 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3816851..3816869 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3816853 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3816888..3817088 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3816888..3817088 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3817058 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3817103..3817424 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3817136..3817339) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3817136..3817339) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3817340..3817640) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3817405..3817408 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3817423..3817442 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3817426 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3817460..3817600 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3817460..3817600 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3817601..3817672 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3817648) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3817651..3817665) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3817673..3817677) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3817673..3818881 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3817673..3818881 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3818862 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3818986..3821043 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3818986..3821043 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3820908 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3821080..3821529) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3821080..3821529) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3821094) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3821526..3823505) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3821526..3823505) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3822007..3822026) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3822010) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3822423..3822430 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3822444..3822462 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3822448..3823114 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3822448 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3823542..3824471) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3823542..3824471) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3824472..3824608) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3824590..3824609) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3824608) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3824624..3824629) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3824698..3824847) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3824698..3824847) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3824724) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3824886..3824905) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3824903) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3824919..3824925) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3824926..3824935 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3824948..3824967 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3824954 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3824966) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3824968..3825481) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3824970..3824984) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3824993..3824997) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3824993..3825475 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3824993..3825475 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3825462 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3825505..3825882) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3825505..3825882) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3825507..3826036 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3825526) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3825937..3825956) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3825949) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3825970..3825977) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3826018..3826022 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3826036..3826055 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3826038 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3826063..3826077) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3826066) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3826087..3827016 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3826087..3827016 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3827002 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3827045) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3827049..3827495) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3827049..3827495) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3827496..3827826) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3827685..3827802) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3827685..3827802) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3827817..3827836) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3827825) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3827850..3827857) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3827863..3827869 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3827882 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3827884..3827902 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3827898..3827904 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3827919..3827930 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3827926 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3827928..3829235 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3827928..3829235 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3829036) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3829224 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3829279..3829518) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3829279..3829518) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3829300) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3829304..3829404) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3829344) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3829508..3829672) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3829508..3829672) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3829684..3829869) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3829684..3829869) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3829950 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3830142..3830288) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3830142..3830288) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3830270..3830419) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3830270..3830419) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3830735..3830751) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3830752) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3830771..3830778 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3830793..3830996 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3830793..3830812 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3830793 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3830814..3830828) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3830818) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3830997..3831434 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3830997..3831434 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3831435..3831511 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3831468 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3831548..3832303 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3831548..3832303 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3832143..3834732) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3832293..3833003 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3832293..3833003 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3832502 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3833000..3833755 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3833000..3833755 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3833752..3834407 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3833752..3834407 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3834408..3834722 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3834679 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3834723 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3834777) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3834782..3835570) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3834782..3835570) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3835594..3835612) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3835613) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3835628..3835633) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3835638..3836027) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3835638..3836027) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3836096..3836099 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3836114..3836133 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3836127 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3836173..3837012 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3836173..3837012 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3836989 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3837045..3838259) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3837045..3838259) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3837063) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3838260..3838363) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3838356..3838375) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3838364..3838371 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3838366) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3838385..3838404 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3838389..3838396) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3838397 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3838446..3839324 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3838446..3839324 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3839338..3839781 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3839338..3839781 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3839864..3840343 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3839864..3840343 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3840333 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3840518..3841180) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3840518..3841180) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3841327..3841779) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3841327..3841779) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3841803..3841810 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3841825..3841844 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3841827 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3841829..3841898 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3841832..3841851) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3841834) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3841864..3841871) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3841899..3842345 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3841899..3842345 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3842342..3842947 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3842342..3842947 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3843042..3843563) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3843042..3843563) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3843564..3844391) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3843612..3843619 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3843633 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3843634..3843653 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3843699..3843973 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3843699 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3843702..3843707 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3843720..3843739 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3843974..3844330 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3843974..3844330 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3844331..3844489 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3844373..3844392) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3844391) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3844407..3844414) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3844490..3845056 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3844490..3845056 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3845563..3846939) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3845563..3846939) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3846973..3847035) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3846973..3847035) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3847056..3847075) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3847075) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3847088..3847095) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3847223..3847229 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3847245..3847264 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3847251 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3847288..3847527 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3847288..3847527 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3847536 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3847620..3847627 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3847643..3847662 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3847659 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3847678..3848094 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3847678..3848094 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3848091..3849008 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3848091..3849008 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3849035..3849054 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3849045 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3849049..3849068) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3849055) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3849080..3851149 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3849080..3851149 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3849082..3849089) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3851113 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3851146..3852045) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3851146..3852045) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3851189) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3852074..3852093) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3852090) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3852092..3853323) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3852108..3852115) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3852186..3852193 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3852207..3852226 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3852213 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3852271..3853626 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3852271..3853626 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3853309..3853328) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3853333) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3853342..3853351) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3853660..3854214) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3853660..3854214) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3854232..3854612) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3854232..3854612) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3854668..3855603) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3854668..3855603) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3855593..3855602 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3855616..3855635 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3855623 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3855647..3855666) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3855661) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3855662..3856420) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3855662..3856420) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3855679..3855686) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3855953..3856456 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3856415 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3856485..3856724) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3856485..3856724) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3856491) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3856559) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3856768..3857286) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3856768..3857286) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3857327..3857614) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3857327..3857614) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3857615..3857681) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3857680..3857699) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3857681) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3857713..3857718) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3857725..3858825) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3857725..3858825) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3858873..3858892) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3858888) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3858907..3858914) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3858952..3860955) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3858952..3860955) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3861006..3861212) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3861006..3861212) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3861174..3861193) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3861199) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3861208..3861214) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3861238..3861257) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3861249) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3861274..3861278) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3861306..3862322) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3861306..3862322) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3862355..3862373) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3862367) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3862389..3862394) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3862498) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3862682..3862687 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3862700..3862781 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3862700 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3862703..3862721 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3862782..3863399 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3862782..3863399 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3863370..3863378 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3863389 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3863392..3863410 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3863411 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3863438..3864286) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3863438..3864286) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3863458) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3864279..3865040) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3864279..3865040) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3865074..3865093) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3865092) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3865184) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3865187..3865195) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3865209..3865217) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3865221..3865229 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3865237 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3865241..3865259 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3865288..3865728 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3865288..3865728 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3865677 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3865779..3866630) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3865779..3866630) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3865798) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3866631..3866751) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3866752..3867471) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3866752..3867471) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3867485..3869371) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3867485..3869371) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3869392..3870771) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3869392..3870771) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3870772..3870902) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3870894..3870913) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3870902) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3870929..3870933) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3870957..3870976) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3870967) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3870990..3870997) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3871057..3871063 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3871068..3873353 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3871068 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3871078..3871097 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3871082..3871708) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3871082..3871708) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3871099) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3871705..3872490) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3871705..3872490) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3872535..3872554) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3872547) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3872549..3872634) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3872566..3872572) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3872635..3872985) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3872635..3872985) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3872986..3873136) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3873137..3873271) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3873137..3873271) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3873295..3873395 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3873307..3873326) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3873317) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3873319..3873387) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3873342..3873349) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3873355..>3873488 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3873355 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3873373..3873392) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3873387) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3873408..3873412) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3873489..3873636 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3873512..3873785) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3873638..3873897 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgagga ggggaagata ttgaatgaac 570001 aaaagctatg tcaggcgata aacctgtttg tggaagtcct gcttgaaggg acagaatttg 570061 tgcatcgtga aatcaatcag gatgtcttca agcatatctc aagggaacag gcagacctgt 570121 tgaaaatttt aaaagtcaag ggcccaacct ctcccggcag cctggccatg taccaaaatg 570181 tacataagag cgcgatctct aacagactga aaaagctgct cgaaaaggga ttggttcaat 570241 gggacgactg tccggaaaaa agtgataggc gctctaagct tattaacatt acacccagtg 570301 gtgaacacat actagaagaa ttagattctg ccatctttaa cgcgctcaaa ccgttgattg 570361 atgatataga tgaggaacac ttacattcta tcatcgagat attcaccatt ttaaaaagca 570421 aatttaaagg aggagattct gccgaatgag agcaatcatc aaattcaagt gggcaattgc 570481 agccatagta ttagcactta ccgtcgtttt gagtttgttt tctccgaact taacggagct 570541 ggccaatcaa aaggggcagg cccagcttcc cgctgatgct gtttcagaaa gggcaaacgc 570601 cattttaaaa caagcgggag aagacaataa ttcgatcagt gtagtcttta cattagacaa 570661 cgctataaag aaagaaacag agaatcagct ccggataata attgataaaa tcaaaaagat 570721 cgacggtgta gaagaggtaa catctcctct gtcagcggaa aaagaagtca aagaccagtt 570781 gatgtcgaaa gacaagaaaa ccgttctcat gcctgtcacg attacaggtt ctgataaaaa 570841 ggcggaaaaa attgcggacg agatttatca aatcgttcct gatgacttga cggcatatat 570901 tacgggagct tcccttatca accaggattt cgctcacagc tcagaggaag ggcttaagaa 570961 aacggaagtg ataacagtct gcctgatcat cggtttactg ttgatcgtgt tccgatctgt 571021 tgtgacgcct tttatcccga ttgtggttgt cggtttttct tatctgatca gtcaatctat 571081 actgggcatc cttgtataca atgttgattt tcctatctcg acgtttacgc aaaccttctt 571141 agttgcgatc ctgttcggca ttggaacaga ttactgcata ctgcttctta cacggttccg 571201 tgaagaattg gcaaacgggc atgataaaaa agaagcggcg cttatcgctt accgcacagg 571261 gggaaaaacc ttatttatca gcggatttgc ggtattgatc ggattttccg ccttaggatt 571321 tgcgaagttt gcgattttcc aatccgcagt aggggtagca gtcggtgtgg gaattttaat 571381 gatcatcctc tacacactgc tgccattatt tatggtgacg ctgggtgaaa aattattctg 571441 gccttctaag aaagtgctgt cacacagtga taacaaacta tgggcgtttc tcggcagaca 571501 ctccgttgcg cgtccgtttc tgttcattgt catcacggtg gtgattacgc ttccgttcat 571561 cttgacctat gatgaccaga tttcattcga ctcaactgcg gaaatcagca gcgattataa 571621 atctataaaa gctctcgagg ccattaagga tggattcggg gaaggaaaag cgttcccgat 571681 caatgttgtc gtaaaaggag acaaagatct tacaacagct gatacaatcc cctatctagg 571741 aaatatcagc aaagcgatcg agaaagttga tcatgttgac tctgttatga ccattacgca 571801 gccgactggt aaaaaaatca aagatttata tattgataac cagctaggat cggtttcaga 571861 cgggctggat aagacggtga aagggattgc cgatgtccaa agcggattaa cggatataga 571921 aaacggactg aatcaaatgg cagggcaaac cggctcggcc tcaaatggag ggtctggcgg 571981 ttcactgggc gatgcggcag atggcttggg caaaatcaat cagcagctgc agctcgtgag 572041 caaacagatt tcccaaaccg gcaataccgc acagaccgtg cagcagctta cggcaataag 572101 cggacagctt ggccagattc aaaccggcct tgaacaagcg aaccaacagc tctcaggcca 572161 gcaggcacaa gccggaacgc tgacagaaag cctgaaaaag ctgtccgaag gcgtgaaaag 572221 cgcaaatgag ggcctgacga aagtctctga cggtattaca gcttccagtg atatattaga 572281 ggacatgagc aaaagtccaa ctgtaagaga tactggcata ttcattcctg atcaagtaat 572341 gaaggacaaa gactttaaga agtcaattga ccagtattcc tttgcagacg gcaaaggtgt 572401 tcaattaagt gtcgttctgg attcaaatcc gtactcagaa caagctatta cgacaataaa 572461 ccaaatcaaa aaagctgtcg caaacgaagt tgacggcact cctttggaga atgcacagat 572521 cgtgtacggc ggggtcacga gtatgaatgc ggacttaaag gagctatcca caacggactt 572581 ctccagaaca atggtgatta tgattatagg cctgtttatc gtgttaacca ttttgttccg 572641 ctcaatgatc atgccgattt atatgatcgc gtcattgctg ctgacgtact atacgtcgat 572701 atccataaca gaattaattt ttgtaaacgg cttaggaaac gcgggtgtca gctgggcagt 572761 gccattcttc agctttgtca tcttgatcgc gttaggggta gattattcga tcttcttgct 572821 ggatcgattt aaggaagagg tgcaccttgg cattgagcaa ggtgtcgtca ggtcaatgag 572881 caaaatggga tctgtcatta ttacagctgc cattatattg gccggtacgt tcgcggcgat 572941 gatgccttca ggtgtcaata cactgatgca ggtggcaagt gttatcatca tcgggctctt 573001 gctttacggc cttgtcatac ttccgctctt catcccggca atcattgcga cctttggaga 573061 aggaaactgg tggccgttcg gcaggaagaa aggaaaagag taatcgagag aagagtgatg 573121 aatggtcatc actctttttt catgactaaa cgactaactt cagacgtgtt acccaaaaag 573181 atcagacgat caaacggcgg ctgtacttaa aaacaaagag cccggaaaac attcccgggc 573241 tctttgtttt atttccattc tgcaattgta tcaatcggca gacggtagga agcatagcct 573301 tcgtctgctg cttttccgat agaaagtagc ataaccggta cataacgttc tttatctaat 573361 ccgaaggttt ccgcgatgtt ttctttatcg tatccgccga tcgggtttgt atcgtagcca 573421 tgcgcgcgtg cagtcagcat cagctgcatg gaaacaagac ctccgtcaat caggatcgtt 573481 tcacggttga cctgtgccgg aagcttttca aaatgtgcgg tcagcgcggc gatttgtctg 573541 tctttgacct cctgcggcat gtaaccaagt tccacggctt ttgaatagat ttcttctaga 573601 tagtctgcgt tgttcatgtc tgcaaataca gcgatgacag cagatgatgt tgtgacttgt 573661 gtttggttaa agcttgcaag cggtgcgagc ttttcttttc cttccgggct gtcaatgaca 573721 agaaaacgcc atggctgcgc gttaacagaa gatggggcag ttgttgcttc ctctaagatc 573781 tctgtcattt cttctttgct gatttttact gccggatcat agttgcggat agaacggcgg 573841 cctttcataa tttccataaa atcgtttgtt ttgatcatgt tgatacactc ctcttaagct 573901 tcgatattat ttatattgtt tcgcatgcgc gccagcacat caatgagcag gcggcgttct 573961 tctgcgctta catttgcgag catttccttc atgaaacgct ccttttcctt cttagaagac 574021 tcaattcgct ctcttccttg gtctgttaac cgaacaaggg tgatgcggtt gtcctcaggc 574081 ttgcgccgcc ttgataccat gcctttggat tccagctgtt tcaggtgtct ggtaacggct 574141 gcgctatcga tatttacttt cttttgaagg tcgctttgac tgatctcatc tgcatgataa 574201 agcaatgtca gcaattccaa acgagattgg ctgatgcccg tgcatgcctc gaacttcacg 574261 ccaatcacct tgttcacgcc ttgcagctga tataaaatct cggcttcctc tgaacaaaat 574321 gacgccaaaa cccatccctt ctttcctgtc aaaactatta attgatatat caatgattga 574381 cacgtcaatt aatatacaac gattgatttc atcttgcaag ccatttgcac ttttgaacaa 574441 cctcccagcg cataaaattc gctaggctag aacttagcaa aaaaagctgg ccgcttcttc 574501 agatgatgct ggtcacgatg attccctgca tcattcccat ttataggtgt tcggaatatc 574561 actttgccgg cccgtgctca agcggctttc acaggctgaa agttatgata caatatacaa 574621 atgtttcaca gcttcaatcc atagttggag ctgacatcca ttatataagg gactaggttg 574681 aagggaaggt ttgataacat gctgcacaat ccaactggaa aagaacgctt ggcactagcg 574741 tttctgctcg gcatgcttgc tatattgggc ccgcttaata tagatatgta tttgccaagt 574801 tttcctgaaa tcgcgaaaga tttatcagca agtgcttcac ttgttcagtt aagtttaaca 574861 gcctgtctgg tcgggcttac gatcggccag ctgattgtcg ggccggtcag cgatgcgcag 574921 ggaagacgaa aaccgctatt aatctgtatt tttttatttg cgttatcttc tctgttttgt 574981 gcactgtcgc ccaatataac aactttagtg gctgcgcgtt ttttacaagg cttcactgct 575041 tctgcagggc ttgtgctgtc tcgcgcaatc gtccgcgatg tgtttaccgg aagagagctt 575101 tctaaatttt tctcgctgtt aatggtcatt accgcggtgg cgccaatggt tgcgcctatg 575161 acaggcggtg ccattttgct tttgccgttc gcaacgtggc atacaatttt tcacgtctta 575221 atgatcatcg gatttttact agttcttctg attgcattga ggttaaaaga aacgcttccg 575281 ctggaaaaac ggattccaag ctcaatcgga acatccgtca aaacgatggg cagcctgctg 575341 aaggatcgat cctttatggg gtacgcgtta actgtcggat ttattcacgg gggaagcttt 575401 gcatatgtgt ctggtacgcc ttttgtatac caggatatct acggggtgtc tccgcaggta 575461 tttagtattc tttttggcat taacgggctg gcgattatat cgggcagctt tatcatcgga 575521 cgctttggcg gaatcattca tgaaaaaagc ctgcttcgta tagcggtcat tacggctatg 575581 attgcgacgg ctgtgctatt aaccatgacc atgattcacg gtcctcttgc tacattagtc 575641 atatccattt tcatttacat gattacgatc ggcatggttc tgaccagcac gtttacccta 575701 gccatggaaa agcaggggca ccgcgccgga agtgcaagtg cgctgcttgg aatgcttccg 575761 ctgctcctcg gttcaatcgt gtcaccgctt gtaggcatta atgagacaac agccgttccg 575821 atgggagcca tcatgtttgt gacagctgtc atcggctcac tggcgttttt tggattaacg 575881 aaagaacgag tagggcagaa ttcataaaaa aacctgacat gacgtcaggt tttttgtttt 575941 atttagaata acaacagcag gcctgcaatc gccggagtca aaaagatggc tgatttcaaa 576001 accacctttg gcatgaggtt ggtgaatttc gcgcctacat aggccccgca cattgtcccg 576061 accagaactt tgacaagtaa aacgtaatca acaaaacctt ctgtaatata tccgatgcct 576121 ccacctacag ccagagggat gatcacaagc atcgtcgttc cgacagaatg gcgaatggac 576181 agattcagca taatcattaa accgatttga ataaaaggtg ccgacccgat gccgaatgtg 576241 ccggaaagaa cgccggctgc aattcctaag atgaccgctc tcgtatacgt tgaaagagtg 576301 ctttgattca cttgagcctt ctcttttaaa ataaataatc tgattaaaat gagaattgct 576361 gataaaaata acattccagc cgtcaaataa tgaagcaaat cagccggaat aaaagaagtc 576421 agcttggcgc cgaaaaatga gccaaccgca gcaaagcctc cgactattaa gccgattttc 576481 atttgaatgt taccctcgcg atagtggctg tatgcccctg ataagcttgt aaaagccatg 576541 ccggcaagcg aagtgcctaa agccgtatga atcgggatat ggaaaagaag cgttaaaagg 576601 gcaatgacaa agccggctcc accggcgcca ataaagccta aaataattcc tagaagaaac 576661 ataacaagaa taatgagcat attttttcct ccattgaaaa gatgtaaaaa tgtaatcgtg 576721 cgctattctg gcggaggtat ggtgtcctat tgacgaagaa aaacacgccg ttttttcagt 576781 tgccagtagt ccgtcgaccg tcgttcagca aacatatcgt acctcaaatt cagggatctg 576841 acaaggcagt ttgttgcttc ccattaccat ctgttatatg attttgatga agaaaagccc 576901 ttgaatatat tcaaaagagg tattatatat ggacgatttt aaattagata agccgactcc 576961 ctactacctg caattttata accagctaaa aaaaatgatc ttcaacggga cttttaagcc 577021 tggggaacgg ataaacgaaa cacagctggc gaaaagcttt ggcgtcagcc gctctccgat 577081 aagggaagcc atgcgattgc ttgagaaaga tggtttgtta aaagcggatg accgaaatgg 577141 gttttcgatc acgtcgttaa cggcaaaaga tgtagatgag atttataaaa tcagaattcc 577201 gctggagcag ctggcagtcg aattagtcat agacgaagcg gacgaagaag agctgaccat 577261 actcgaaaaa cagcttgaag aaacagagaa agcgattcac aacggcacgg aagatacaga 577321 aatcattcgt ttaaaccaaa aatttcatga gctgctggtt gatttcagcc ataacagaca 577381 tttgaaaaat ttgcttgagc atgtaaatga cctgattcat ttttgcagaa tccttaatta 577441 taccggcgac caccgcgcag aaacgatact gcgtgagcac cgcaggatat ttgaagaagt 577501 gaaaaagaaa aacaaagaag cagccaaaca acatgtgctg gctcatttca atcatgactg 577561 tgagcatttg aagcatgtgc ttgaagaagg taaagagaat tgatttgtat gatccggtac 577621 caagggagag cagaaccctt ggtatttttt tatgtattca ccacatatct aagaggcccc 577681 gttaataaga ttttatgatg gtttgactaa cgaataatgg gggttaaata tgtttatcca 577741 tatcgtcggg cctggtgatt ctttgttttc gataggcaga agatacggtg cttctgttga 577801 tcaaatacgg ggtgtgaatg gtttagatga aacgaatatc gtgccggggc aggctctgct 577861 tatccctctt tatgtatata cagtccagcc gagagatacg cttaccgcca ttgcagctaa 577921 agcgtttgtg ccattagagc gactgcgagc ggccaatccg ggcatcagcc caaatgcttt 577981 acaagcggga gcaaaaataa cgattccttc gatctcaaat tacattgcgg gaacgttaag 578041 tttttatgtg ctccgaaacc cagacctcga tcgggaatta atcaatgatt atgcgccata 578101 ctcgtcttcg atttcaattt tcgaatacca tattgcaccg aacggcgaca ttgcaaacca 578161 attgaatgat gcggccgcta ttgagacaac ttggcaaaga cgagtcacgc cgctggcaac 578221 aataacgaac cttacatcag gaggcttcag tacggagatt gttcaccaag tgctaaacaa 578281 tccgacagcg agaaccaatc tggtcaacaa catttatgac ttagtttcca caaggggata 578341 tggcggtgtc acaatcgatt ttgagcaggt gagcgccgcg gatcgcgatc ttttcactgg 578401 atttttacgc cagctgagag atcgacttca ggcgggaggg tatgtgctga cgatagctgt 578461 tcctgcaaaa acaagtgata atatcccatg gctgaggggc tacgattacg gggggatagg 578521 agcggttgtc aattatatgt ttatcatggc ttatgattgg catcatgcgg gaagtgagcc 578581 gggtcctgta gcgccgatta ctgaaataag gagaaccatt gagtttacga ttgcgcaggt 578641 gccgagcaga aaaatcatta tcggagtccc gctctacggg tacgactgga tcatcccgta 578701 ccagccgggc acagttgctt cagcgatttc aaatcaaaac gcaatcgaaa gagcgatgag 578761 gtaccaagcc ccgatacaat attcagccga atatcaatca ccgtttttcc ggtacagtga 578821 tcagcagggg cggacgcatg aggtatggtt tgaggatgtc agaagcatga gccggaagat 578881 gcagatcgtc cgtgaataca gattgcaggc tattggcgct tggcagttaa cgctgggctt 578941 tacgccgggc ccatggcttc tgcggaaatt ttttacgatc agaaaagtgt aaaaaaagac 579001 accagagctt gggtgtcttt tttttgatta agtccagagc agcagaatag ttcattcatt 579061 tgtaccttgc atgggttgtg ttcccatttt acgattagta gtagtctgat caaacaaaga 579121 gtcagaatac gatttgagag ggagttgtct acatgaagac agtattgatt ttgaattttc 579181 ctgcggaagg ccatgtgaat cctactttag gcattacgaa agcgttttcc gataagggat 579241 atgatgtcca ttatatatcc actgaaaaat ataaaaaacg attagaagca gcgggagcaa 579301 cggtccatct tcaccgggat ctgctgcgaa cgacacctat tcatgtcggt tcgcccaatg 579361 gcattcttga tttcgtgaaa atccatatca aaacgtcatt ggacatttta cagattgtca 579421 aagacttatc taagagcatt caatttgatt ttgtttatta tgataaattc ggcgcggggg 579481 aattggtgag ggattactta gatattccag gggtctcttc atcggcgtct ttcctgtttg 579541 gcgaggagca tctgaaaatc ctgccgctgc atccggagtc tggagcgccg cttgaattgg 579601 atcaagagtg cgaagacctt ttggcaaaaa tgaaagaaac gtacggtgtt gccccgaaaa 579661 acctggttca attcatgaac aataaagggg aattgaacgt agtgtataca agccgttatt 579721 ttcagccaga aagtgatcgt ttcggggatg aatgtctatt tatcgggccg agctttccaa 579781 agagagcgga aaaaacagat ttcccgattg aacagctaaa agatgagaag gtcatttata 579841 tttcaatggg gactgtactg gatcatacag aggatttctt caacctttgt attgatgcat 579901 tttcaggctt taacggaaaa gtcgtcatcg ctgccggaga aaaagcggac ctgaccaaat 579961 taaagcaggc gccggaaaac tttatcattg ctccgtatgt ccctcagctg gaagtgctgg 580021 agcaatcgga tgttttcatt acacacggcg gaatgaacag cgtaaacgaa ggcattcatt 580081 tcagcgtgcc actggttgtc atgcctcatg acaaggatca gccgatggtg gcgcagcgtc 580141 tctctgaact ccatgcaggc tatgtcatct ctaaagatga agtcaatgcc caaatattaa 580201 aacaggccgt agatgaggtt ttgcgcaacg atcagtatac ggcaggcatt aaaaaaatca 580261 atcaaagctt caaagaatgt atggacatgg aagaagtgat ggagcggatt gatgagttga 580321 ttcgccaaaa aaacaaataa gaaaaagaac tcccgtacct tgtacgggag ttcttgattt 580381 aaaacttgat tttgattttt tgagcatcac tgattttctt atggttatgg tcaaagacgt 580441 cacttgtcgt gatttcgatc cacttgatct cttttgtttt cttctcagca tccgcggcct 580501 tatcatgagc atggccgctt gatgcgttca caataaagcc gagatttccg gacttttcgg 580561 cgccgccttc caattcgccg tttaactctt caagataaat atctttgttc caatcaaagg 580621 tttcacccgt atttgttttc atcaatgcaa tcggcgcaac atttactttt tttgtagagg 580681 tgttcttgat atcaacgaaa accttaacga aatcaaactc ttcatcgtgt gttaactcat 580741 gaaagtaatc aatcatgctg tagtccgggc gcaagtggat cagcttcatt tcttttactg 580801 ttaactccac gtcgccaatt ttataggttt tgttcacttg tttgatatct tttaagacag 580861 cttttccttt atcatctgaa aacgtttggc cgaccttatg caatgtccgg tcatcagtta 580921 cctgggaatt aggctgataa tcatctgtgc tgtccttctg ggatgaagtg ctttgcggct 580981 cagcttttac tgttttctcc ccgcctgcat gctgtttttc agtactggcg tttgatgagc 581041 agcccgcaag catgatagca aaaacgagaa ttgaaagaat tcttctcatg atgattcctc 581101 cattaaaaag agatcccgtt acttcataca agcaacggga caccttgtat tcttttactt 581161 atcgttaatc ttaatgttgt attgtaaagc cttgaaaaca tttttggcga tttctgtatt 581221 gtcgatttgg ccggcaaatg tctcactaga cggaccgtat gcatagacgg gaacatcttc 581281 accggtatgt ccgcctgttg tccatccagt gtgagagcgt ttattaaaga tgttctcgat 581341 tgcgttatcg atatccagta cttccttcga ttttgccgct tcttcaacag attgaatttc 581401 ggcttttgtt aaagccaatt tcttttgatc gatatatgtt ttcaacgttt tttcaacatc 581461 cgcgccgtca gcgatctttt ctgccataaa gtctggtgtg cgctttgcgg ctttaatggg 581521 ttcactgaac cagttgtaga tgccgtccgc accgatggaa tatccgccgg ttgagtggtc 581581 agccgttgcg acaaccaatg tgtgcttgtc ttttttagcg aaatcaatag ccgccttata 581641 agcttgttcg aagtcttcca tctcgctcat ggcgccaacg atatcattgt catggcccgc 581701 ccagtcaatc tggctgcctt ccaccatgag gaagaatccg tctttatcct tgtttaattt 581761 tttaatggct gtgtttgtca tatctttaag tgatggaata tccttcgtac ggtcaatctt 581821 tttaggcagg ccgccgtcag cgaataggcc gagaacttgg ctgtctttgt ttttcagcat 581881 gtccttgcga tcatccacgt agctgtaccc cgcctttttg aattccttaa tcaaattacg 581941 gtccttacgg tcaaaattgc tctttcctcc gcctagaagg acatcaattt tgtgcttgcc 582001 gttgaccatc tcatcaaaat aatcatccgc aattgagttc atattttttc ggctgtggtc 582061 gtgtgaacca aaagaggccg gagtggcgtg tgtaatttct gaagtggcca caagtcctgt 582121 tgcttttcct ttttctttcg cagcttcaag caccgttttg gcttctgacc cgtcgttatc 582181 aacggctatg gcattattgt atgttttaat tcccgcagac atagccgttg ccgccgctgc 582241 agaatccgtt acattttgtt caggatcatc ggggtaagtt gtttgctggc cgacaagata 582301 ctgatcaaaa gccgtaggct ccacaacttt tgtcttttta ttatccttta agtatcgata 582361 agcagacgta taagacacac ccataccatc accaatcaga acaataacat ttttaatttc 582421 gtcttggttc ccctttttct tttcctgggc gctggcttca ggcacactgc cgctggctaa 582481 gctgctgaac gcaattgatg ataaaaccgc gataggcagt aatttcttcg ggaatttttt 582541 caactggata acctcctaaa tatagatgaa tctcaatgac aacccaatta tatttttaaa 582601 ctgttaagct agtattaatc gattttaaag attggattta caagaataat gaactggcac 582661 ccttaaataa tggttattct tttatgagaa gttttagaag gaaagagcga tagtactaaa 582721 gaaataaatt ggaggaatag atactggccg tggataggcg gactgaaatc tgctatagtc 582781 gcatagaagc aacccgctta catcttgaac aatttaaagt attacgttgg aaagaggtat 582841 tgtgtaagca catgtctgag cagttcatat ggagtggcat cattttattt taggagggaa 582901 caacatggac gttttttctg agtacttagc ggggattgct gacccgttcc accgagaaag 582961 aacggaagag gtgttaactt ggataaaaaa taaatatcca aatttacata cagaaataaa 583021 atggaatcag ccgatgttta cggatcacgg tacatttatt attggcttta gtgtttctaa 583081 aaagcattta gctgtcgctc ctgaaaaagt aacgatagcg cacgtagagg atgatattgt 583141 gaaggccgga tatgattaca ccgagcagct gatacgtatc ccttggaacg gtccagttga 583201 ttatacgcta cttgagaaaa tgattgagtt taatattctg gacaaggcgg actgctccac 583261 tttttggcgg aaatgaagaa aaaggcataa catatgagct gtataaaata tgttacgcct 583321 tttcatttgt ctatttttcg ttttgatcat ctattgctgc ttttcatcaa acaaggtctt 583381 ttcattgagc gtaagctgac tcgcagaata atgattacct tgtttccatt tcacttcaat 583441 cgtaatatca tggccttcaa gctcatgttc atctaaccgc tctaaaaaag aaacggactt 583501 ttcttttgcg cttccatcag aaaaagtgcc tccagcataa tcatgcatcg ggatttccgt 583561 gtcagaactc agcagaactt catcatcctt ttttacaatc agtgattcca gataagtgtt 583621 gtctatttca attgtatcac cgatccaata aagtttgccg ctgtattcat tcggtgcatc 583681 ttcatttttt gtgaaaacag cttcccaatt ctgatctttg ctttctccct gccaatttgg 583741 atactccaaa cgaacatgat gaatcaggtg ataggaaaaa aagatcaagc agaaagcgat 583801 taataggaat gccgtgaaaa tgagagggta tttataatga ctggacataa aagactccta 583861 ttcgtttaat caattacctt cgaaaataga atttcatccc gaatcaaaat gccgttttca 583921 gccacctcgg gaatctccgg cttgagtcgg cgcgcttttt caactgcgtt cggaaacact 583981 gcggcgaatt gatagcctct cttttgataa aacgctatcg catttacatt atcattcgtt 584041 gtgataagct ttattcgttg acaatgtgca tgtttagcct tctcttcaac ctgctgaagt 584101 aaagctgtgc cgattccttt attttcaatc atactatcta atgaaataat ttcacaatct 584161 ttcccatcta ttgtgtatgt aatacagcca atgatttcgc cgctttcatt tactgcggca 584221 aatccatcta attcatcaca ccgaaaaatg ccgctggaaa tcgccatctc gggtgtaccc 584281 caatgcttgg caaaaaaatc ggtcaacata tgtttcgcta tctcattgtt tgggatgatg 584341 atcatcataa cactcctcta ttgaaagatt gcatatgtac tatcaatata aacaatatat 584401 aacaaaaaaa atagatgttg aggtgacggc atggaaatca gcgatatcat ttacgggcag 584461 caccatatag acggagtgct ggaagagctt atcaaaagcg ctcctgtgca aagattaaaa 584521 ggaatctatc aaggcggagc aagcttttta gtcaatcgaa agtggaatgt gaccaggtat 584581 gagcactcca tcggcgtgat gctcctcatc aaaaagctcg gaggaacgat agaagaacag 584641 attgcgggtc tgctccacga cgtatcacac acagcttttt ctcatgtggt cgacgttgtc 584701 tttgaaaatc aagcagaaga ctatcatgaa aacatctttc aacaagtcat tgttcactct 584761 gaaatcccgg acattttaca aaaacacggc tatcatactg aagaactttt atctgacgat 584821 tcaaggtgga cattgctcga acagcccgca ccggagctgt gtgctgatcg gacagactat 584881 acgctgcgtg atatgtaccg atatggacac attaacctgc acgaagcgca aacctttttg 584941 gatcatctta ttgtgagaaa cggaaggatg tttcctgata gtattgaagc cgccgaatgg 585001 tttgtcagtg tgtactacaa ggaagtaatt gatttctttt tgaatcctgt gaatgtatat 585061 ggatatgaat atttagcgcg agcattgaag gcagcgctgc ggcatgatgt catatctgca 585121 gaggatctgc tgaaaacgga ccaagaggta ctgaacatcc tgcgtgcatc aaaaaatgaa 585181 gaagtcctga gcttgcttac atccattcat cccggcatac aagtaataga ggatgacatc 585241 cagtacgatt tccatcaaaa gaagaaaatg cgcctaatcg atccatccat ttttcttgat 585301 gacaaatgga tcaaatcctc aggtgtttct gaaaaggtga ggaaaatggg tgaggccgct 585361 tatcaaaaag caaaaaaagg tgtgtatata aaaatcttaa agcagtaatt gccgcctgac 585421 agcggctttt tttatgtttg gctttgcaaa caaaggggaa taggacaaac tgcgggaacg 585481 ctttatgaga atatcagcgt atttacatac cgttcggggg tatagtatta tcgagagggc 585541 atgttttcat tgtctgcggg caaaagttac aggaaaaaaa tgaagcaaag gagaatgaac 585601 atgaaaatct ctaaatatgc actgggaatt ctgatgttat ctctagtttt tgttttatca 585661 gcatgcggca ataacaacag tacgaaagaa agcacacatg acaatcattc agactcctca 585721 acacatgaag agatggacca ttccggatca gctgacgttc cagagggatt acaggaatct 585781 aaaaatccga aatacaaagt aggcagccaa gtaatcatca atacttctca tatgaaaggc 585841 atgaaaggtg ctgaagctac ggtaacaggc gcctatgata caacggcgta tgttgtttct 585901 tatactccga ctaatggggg acagcgtgtg gatcatcaca aatgggtgat ccaagaagaa 585961 atcaaagatg ccggagataa aacgttacaa cccggagatc aggtgatttt agaggcttct 586021 catatgaaag gcatgaaagg agcaacagcc gagatcgatt ccgcggaaaa aacaactgta 586081 tacatggttg actacacatc gacaacgagc ggcgaaaaag tgaaaaacca caaatgggtc 586141 acagaagatg agctttcagc taaataataa aaaatcctcc ttttacaagg aggatttttt 586201 tgctgtttga acaggtcttg ttaaagaaat gaaagcaaac aggacagcga tgatcacaat 586261 cgatccgccg caccatgccg ttgacaccac agtacccgtc tgatccaaaa caacaccgcc 586321 aatggctgag ccaagggcaa ttccgacttg gagggccgat gtgttaaagc tttgctgaat 586381 gtcagacgaa tcaggtgcaa tttcaattaa atagctttgc tgagccgggg cgaggctcca 586441 gctcagaaga ccccaaatca ccatgacagg caaaaagaaa atcatagacg atgtagacag 586501 cggcagtaag aacataatga tggcaaagga accggtcacc agcaaaatgc tcttaaagga 586561 accaagccgg tcagatagcg ctcctccgaa agggcctccg catacagcag atatcccgaa 586621 aaggaaataa caaatgctga cccagaaaga gctcaggtga agagtctctt ctaaaaacgg 586681 cgcaaagtaa gcgtaaagcg tgtagtggcc agctaatgta aacatcgtga cgaggtgtga 586741 actcgcgatt ttcagattac cgatcgtctt gagttgttcc cggaaaggaa tcattttctc 586801 cgccggtatt ctttcaaaga agattgaaat aatcagcatg gagatcagtg ccaacaggcc 586861 gatgccaagg aacaaaatcc gccacccgaa ggaatcgctg attaagattc cgagcggcac 586921 gcctaatgcg atagcagagc tgaatcccat aaaaataatt ccgattgcgc gggctctgta 586981 ttcaggcgct acaattttcg gggcaattgt taaagaaagc acaacaatca gccctgtact 587041 cattgctgcc aataccctag ataccatcag tgttgcgaaa ttagggctga aataggcgac 587101 aagattgcta aggaagaaaa caaataaagc aattagatat aagcgcttcc gctcaatctt 587161 cgcagtcaat gccaaaagca gcggcccaga tactgcatat cccagcgcaa acacactgat 587221 cagctgtccg gctgaaacaa tggaaatgtc taaatcattt gcgatctgag gaagaattcc 587281 ccccacaatt aactcaacca atccgactgc aatcgtagaa gctgcaagca ggaaaacttt 587341 gaaattcata acaaactcct ttacttaaat gttttgataa ataaaaaaaa tcctgattac 587401 aaaaaatgtc ataaacaaat tttgtaatca ggattttacg gttcctggta gacaccctca 587461 aaccatatta ttgaggttat acaagtgata atagctattt aattgattcg tttccgttga 587521 tgagtgtacc acattatgaa tgaatcttcc atagaaaaat ttataaaacg gtgaaccgga 587581 aaaaaatatg attatattta ttttataaaa gtatagacat ttaaaattaa atgactataa 587641 taatcaatgt aagcgtttta ataacagggg ggatagcagt tgaaaaaaat attactcgcg 587701 tgcagttcag gaatgtctac cagtttattg gtgacaaaaa tgaaggaata cgcacagtct 587761 atcggtgagg aagcggagat ttgggctgtt ggccaggata aagcaaaaga agacatgaga 587821 aaagcggatg ccgttttgat cggtccgcaa atgagctttc tgaaaagcga gctccaaaaa 587881 gaagcagatc aatacaacat tcaagttgaa gtcattgaca tgatggccta cggaatggca 587941 gatgggaaaa aagcgtatga gcaggcattg tccttaatgg tgaatcaata atggaacaga 588001 tgaaaatcac gaatttaaca gacgagcaaa tcagttttca gctaatcctg cacagcggaa 588061 atgcccgcag ctgcatcata caatcactgc gcgcctataa agaagggaaa aaggacgagg 588121 ctgatgccct cattgccaag gcggagcagg atttatccgc ggcccatgac attcactttc 588181 aaatgataca gaaggaatcc ggcggagaag caacagcttt ttcattgctg cttatgcatg 588241 cagaggatca tctgatgtca acattatcca tgaaagaatt agtgaaagag atgcttgatc 588301 tctttaaaac caagaatata taaaaaatcg gggtggatag ggtgttcgag aaaatcagcc 588361 aattccttgt tccaattgca gggaggttaa acaataaccg ctatttgcaa gtgttgcgtg 588421 atgcatttat gctggctttc ccgctgacga tattcgggtc catttttgtc gtgttaacga 588481 atttgccgtt tctaaacaaa atcatgaacg cctcaatgct tacgtcgttt cagtctcatt 588541 tcggcattgc ctccacggcg acaatgggca ttatgtctgt ctttgttgtg ttcgggatag 588601 gctattacct gtcgaaaagc tatcaggtcg aagctgtatt tggcggagcg atcgctttgg 588661 tttccttttt gctcttaacg ccatttatca ttcagccgga aacaggtgat gccattacag 588721 gggttatccc ggtcgatcgt ctcggtgcaa aagggatgtt tcttgggatg attacggcat 588781 ttctttctgg cgaaatttac agaagaatcg ttcaaaaaaa cctgacaatc aaaatgccag 588841 ccggcgttcc gcctgctgta gcaaaatcat tcgccgcact tattccggct tttatcacat 588901 tgactgtatt tttgctgatt aacgtaatgg tgactctgtt ttttaaaaca aatatgcacg 588961 acgtcattta tcatgcgatt caggctccgc ttgtcggact tggaagcggt atcattccaa 589021 cactgattgc cgtgtttttc attcaaattc tttggttttt cggactgcat ggacagatca 589081 ttatcaactc cgtgatggac ccgatttgga atacactgca ggtagaaaac ctttctgctt 589141 acacggcggg aaaagaaatc cctcatatta tttcaaaacc gtttatggag atttatacag 589201 tagggatggg cggaacaggg atgacgcttg cgattgtgtt taccattctc atattcatga 589261 aaagcaggca gatgaagcaa gtatcaaaac ttggcctcgc tcccggtatt tttaacgtaa 589321 acgaaccgat tatctttggg cttccgattg tcatgaatcc gatcattatt gtgccttggg 589381 tgctggcacc gatggttgtt acgctcgtca cctatctggc tatgtcagcc gggctcgttc 589441 cgcctccaac tggtgtgaca gtgccgtgga cggttccatt attcattaat ggcatcatgg 589501 cgacgaactc aatcatgggg ggcgtgatgc agcttatcaa tctgctgatt gtcttcgtga 589561 tctggtttcc gttcctaaaa gcaatggata aattaaatct ggcaaaagaa aaagaacagg 589621 ctgtgcagga gacagctgct cagcaaaatg ataacagcat aaaaatgtga cataagggga 589681 gagagacttg gcacatacag aacaatatcg ttttccaaag gatttttggt ggggatcatc 589741 cgcttcagca acacaaatgg agggtgccgc cgacagagac ggaaaaggcc agaatatatg 589801 ggattattgg tttgaaaaag aaccgcatcg tttttttgat catgtcggac ccgcagacac 589861 atcccaattt tacgacaact ataaagaaga tatcaggctg atgaaggaac ttggccacaa 589921 ctcgttccgg atgtcgattt cctggtcacg tttaatacca aacggaacgg gcgagatcaa 589981 cgataaagcc gcagatttct ataacaatgt cattgatgag ctgatcgcta acggaattga 590041 accttttgtc aatttgtttc atttcgatat gccgatggcg cttcaaaaaa tcggcggctg 590101 ggtcaacaga gagacggttg acgcgtatga aaactatgca agaacttgct tccgtttgtt 590161 tggcggccgg gtgaaaaaat ggttcacgca taatgaacca atcgttcccg tagaaggcgg 590221 atacctatat gattttcatt atccaaacaa ggtcgatttt aaagaggccg tccaggttgg 590281 atttcatacg atgctatcaa gtgcccgcgc cattcaggct tacagggaga tgaagcagga 590341 cggaaaaatc ggcatcatct taaatttgac cccttcatac ccgagaagca gccatccggc 590401 ggatgtgaaa gccggggaaa tcgcagacgc gttttttaac agatcttttt tagacccatc 590461 tgtcaaaggc gaatttccca aagagctggt tgacattttg aagcatgaag gctttatgcc 590521 tgattacaac gctgaagatc tcgacatcat caaaaagaac acggttgacc tgttgggagt 590581 gaattattac cagccgagac gtgtgaaagc gaaagaacat cttccgaatc ccgacgctcc 590641 ttttttgccg gacaggtatt ttgatcccta cgtcatgccg ggccgcaaaa tgaatccgca 590701 tcgcggctgg gagatctatg aaaaaggcgt ttatgatatt ttgatcaatt taaaagaaaa 590761 ctacggcaac atcgagtgtt ttatctctga aaacggtatg ggggttgaag gtgaagagcg 590821 attcagggat gaacaaggca tcattcagga tgattaccgg attgaattta taaaagagca 590881 cctcaaatgg attcaccgcg ccatacagga aggctcgaac gtaaaaggct atcacttatg 590941 gacgttcatg gacaactggt cttggacaaa tgcctataaa aaccgatacg gatttgtatc 591001 agtcaatctt gagaaagacg gagaaagaac cgtcaaaaag agcggaaaat ggttcaaaga 591061 ggttgctgag catagcggtt tctagatttt cctaaaggtc aagatcttcc ggcaatcatc 591121 ataacgaata gagatgacga aaatccgcaa cattgatgaa atagggaaaa gaacttatga 591181 tatccgtaaa agcttatgtg atatcaaaca gctgccggag gataccaatg aataaatacg 591241 aaatcattgc aaatgaaatg agaaatagaa ttaaaaataa cgtatatccg atcgatcagc 591301 ccattcctga tgaagtatct cttgcaaaag aatttaactc aagccgcatg acgatgaaga 591361 gagccttgga taatttagtt gccgagggtc tgctgtttag aaaacgaggc catggcacgt 591421 ttattattca atctgcaata caggatgacc atgtccatgt agtcagcaat gagattctcg 591481 gattgaccaa cttgctgaaa gataaaaaaa tcaaaagcaa ggtcattcag tttgaagtgc 591541 aatttcccac tgaggaagtg gccgcccatt tgtctattga tcagaaaaca ccggtttatt 591601 atgtcgttcg gctgcgaatt gtagaaggtg aaccctatgt attagaaaaa acatatatgc 591661 cgactcattt aataccgggc attaatgacg atgtccttca tgattcgatc tacaatcata 591721 ttacaaatgt gctgcagctc aaaatcgccg gaacgcatcg gaaaatcaga gcctgcaaat 591781 ctgatcatat tgaccagcag catctgggct gtaaacagga tgatccaatt cttgaagtgg 591841 aacatgtggg cttcttagat accgggattc catttgaata ttccttttca cgtcatcggc 591901 atgacaagtt tgttgtgact tctgtaaaca tacggcgctg attgcggaga caacaaggag 591961 gccatctgca tgcttggcgg tattgaagca ggcggcacaa agtttgtttg tgctgtcggt 592021 agagaagatg gaacgatcat tgacaggata gaattcccca caaagatgcc ggatgaaacg 592081 atagagaaag taattcaata ttttagccaa ttttcattac aggcaatcgg catcggctcc 592141 tttggtcccg ttgataacga taaaaccagt caaacatacg gtaccattac ggccacgccg 592201 aaagcgggct ggagacacta tccctttttg caaaccgtta agaacgaaat gaagatccca 592261 gtcggattta gtacagatgt caacgctgcg gcgctgggtg aattcctttt cggtgaagcg 592321 aagggtcttg acagctgcct gtatataacg attggcactg gcatcggagc gggggctatt 592381 gtagagggga ggctccttca ggggctgtca cacccagaga tgggccatat ttatatccgg 592441 aggcacccgg atgacgtata ccaagggaag tgcccttatc atggagattg ctttgaaggc 592501 ttagcttcag gccccgctat cgaagcccgc tgggggaaaa aagccgcgga tttatcagat 592561 atagcacaag tctgggaact ggaagggtac tatattgccc aagcactggc tcagtatatt 592621 ttgatccttg cacctaaaaa aatcattctt ggcggcggcg tcatgcaaca gaaacaagtg 592681 ttttcttata tctatcaata tgtaccaaaa atcatgaaca gctacttaga tttttctgaa 592741 ttatcagatg atataagtga ttatattgta cctccacgtt taggcagtaa cgccggaatc 592801 atcggcacgc tagttttagc gcatcaggcc ttacaagcag aggcagcatc cggggaggtg 592861 cgatcatgac gcatccatta tttttagagc ctgtctttaa agaaagacta tggggaggga 592921 cgaagcttcg tgacgctttt ggctacgcaa taccctcaca aaaaacaggt gagtgctggg 592981 ccgtttctgc acatgcccat ggctcgtcgt ctgtaaaaaa tggcccgctg gcaggaaaga 593041 cacttgatca agtatggaaa gatcatccag agatattcgg gtttccggat ggtaaggtgt 593101 ttccgctgct ggtaaagctg ctggacgcca atatggatct ctccgtgcaa gtccatcctg 593161 atgatgatta tgcaaaactg cacgaaaatg gcgaccttgg taaaacggag tgctggtata 593221 tcattgattg caaagatgac gccgaactaa ttttgggaca tcatgcaagc acaaaggaag 593281 agttcaaaca acgaatagaa agcggtgatt ggaacgggct gctgaggcga atcaaaatca 593341 agccaggaga tttcttttat gtgccaagcg gtacactcca tgctttatgt aagggaaccc 593401 ttgtccttga aatccagcaa aactctgata caacatatcg cgtatacgat tatgaccgct 593461 gtaatgacca gggccaaaaa agaactcttc atatagaaaa agccatggaa gtcataacga 593521 taccgcatat cgataaagtg catacaccgg aagtaaaaga agttggtaac gctgagatca 593581 ttgtttatgt gcaatcagat tatttctcag tgtacaaatg gaagattagc ggccgagctg 593641 cttttccttc atatcaaacc tatttgctgg ggagtgttct gagcggatca ggacgaatca 593701 taaataatgg tattcagtat gaatgcaatg caggctcaca ctttattctg cctgcgcatt 593761 ttggagaatt tacaatagaa ggaacatgtg aattcatgat atctcatcct taatgaatgg 593821 gggagttgca tttgtttaag aaacatacga tctctttgct cattatattt ttacttgcgt 593881 ctgctgtttt agcaaaacca attgaagcgc atactgtgtc gcctgtgaat cctaatgccc 593941 agcagacaac aaaaacagtg atgaactggc ttgcgcacct gccgaaccga acggaaaaca 594001 gagtcctttc cggagcgttc ggaggttaca gccatgacac attttctatg gctgaggctg 594061 atagaatccg aagcgccacc gggcaatcgc ctgctattta tggctgcgat tatgccagag 594121 gatggcttga aacagcaaat attgaagatt caatagatgt aagctgcaac ggcgatttaa 594181 tgtcgtattg gaaaaatggc ggaattccgc aaatcagttt gcacctggcg aaccctgctt 594241 ttcagtcagg gcattttaaa acaccgatta caaatgatca gtataaaaaa atactagatt 594301 cttcaacagt agaaggaaag cggctaaatg ccatgctcag caaaattgct gacggacttc 594361 aagagttgga gaaccaaggt gtgcctgttc tgttcaggcc gctgcatgaa atgaacggcg 594421 aatggttttg gtggggactc acatcatata accaaaagga taatgaaaga atctctctat 594481 ataaacagct ctacaagaaa atctatcatt atatgaccga cacaagagga cttgatcatt 594541 tgatttgggt ttactctccc gacgccaacc gagattttaa aactgatttt tacccgggcg 594601 cgtcttacgt ggatattgtc ggattagatg cgtattttca agatgcctac tcgatcaatg 594661 gatacgatca gctaacagcg cttaataaac catttgcttt tacagaagtc ggcccgcaaa 594721 cagcaaacgg cagcttcgat tacagcctgt tcatcaatgc aataaaacaa aaatatccta 594781 aaaccattta ctttctggca tggaatgatg aatggagcgc agcagtaaac aagggtgctt 594841 cagctttata tcatgacagc tggacactca acaagggaga aatatggaat ggtgattctt 594901 taacgccaat cgttgagtga atccgtaatg tcacaattaa gaaggtgctc aagaagtttc 594961 ttgagcacct tcccactgga ttaagcattc atatcgccta acccaggact gtgttcattt 595021 ggtatttcag gaagcactgg tacgggaaac cctgccggag gatctattac ttgtaactct 595081 ccgccatttc ggcttggaga tttcccttga tagatttcac tgattctcgt ttcatccaac 595141 ctaaagttaa aatgtgtatt atggtagcct aattcgacat actttctgca ctcaggatat 595201 ttattaatgt cataattcgg cacagggagc agcttcgccc attcaacgcc caatgtctcg 595261 agcgctttcg cgaatgcatt ctggtgagca ttgtcgcgta caatcagaaa agcaagtgtt 595321 tcgcggaacg tctgattaga gctcatttca taaattcttg ttttttgcag cacacctgtc 595381 gactcaagaa gcaggttatc cagcaggtca gtaattaagt ttccgtggtt atacacccac 595441 gacccgttcc acggattgcc ccctgcatca acaggaaggg aactttgcgc tccaataata 595501 taatgatgag gattagcatg tttaaccgct tcatcaagtg gcgcttgatc tgtaccttga 595561 ctgccgacac cttcaccgcc tgattcatct aataaagcat tgattgtgtt ttgaaccagt 595621 tcaacgtggg caatctcctc taaaaaaatg ccgcgaagca gatcgcggta ctgtttctgc 595681 tttcctctga aattagagct ttggaaaaaa actgcatcat tgtacgcatt tctccgtaat 595741 gaccgcctaa tatctcctgc aggaccttag cagctgccgg gtctggcttg tccggtttaa 595801 tgatattaat cagttcctct ttgtagtaat acataacacg cctcatttct tcttaagaga 595861 ttttcttata ttatttgtaa gatgagataa aatatataca tgataagcat gggaaggcgt 595921 gaaagaagaa aataaaaaaa tacaggaaaa gtgttgacca aataaaacag gcatggtata 595981 ttattaaacg tcgctgatga acagcgtgaa acaaaacaga aaaacaaaaa agttttccta 596041 aggtgtttac aagattttaa aaatgtgtat aataagaaaa gtcgaattga aaaagattcg 596101 aaaaaacatt aaaaaacttc ttgacttcaa catcaaatga tagtatgata gttaagtcgc 596161 tcaataagcg cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg 596221 gttcgactcc tctcgggcgc gccatataag ataccacgcg ggtgtagttt agtggtaaaa 596281 cctcagcctt ccaagctgat gtcgtgagtt cgattctcat cacccgctcc attattgaat 596341 gatctttgaa aactaaacaa gacaaaacgt acctgttaat tcagtttttg aaaatcgcac 596401 agcgatgtgc gtagtcagtc aaactagggc ctgcacgatg caggtcacac aggtgtcacc 596461 gcgggatgcg gtggacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg 596521 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg aacagatggg agcttgctcc 596581 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 596641 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 596701 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 596761 atggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 596821 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 596881 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 596941 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 597001 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 597061 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 597121 accggggagg gtcattggaa actgggaaac ttgagtgcag aagaggagag tggaattcca 597181 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 597241 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 597301 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 597361 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 597421 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 597481 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 597541 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 597601 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 597661 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 597721 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 597781 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 597841 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 597901 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 597961 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 598021 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 598081 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 598141 ttgaaaacta gataacagta gacatcacat tcaattagta atacaagata tcacatagtg 598201 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 598261 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 598321 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 598381 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 598441 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 598501 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 598561 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 598621 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 598681 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 598741 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 598801 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag 598861 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 598921 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 598981 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 599041 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 599101 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 599161 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 599221 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 599281 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 599341 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 599401 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 599461 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 599521 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 599581 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 599641 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 599701 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 599761 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 599821 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 599881 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 599941 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 600001 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 600061 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 600121 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 600181 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 600241 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 600301 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 600361 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 600421 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 600481 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 600541 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 600601 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 600661 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 600721 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 600781 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 600841 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 600901 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 600961 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 601021 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 601081 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 601141 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 601201 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 601261 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag cattactttt 601321 atcatcgcgg ggtggagcag ttcggtagct cgtcgggctc ataacccgaa ggtcgcaggt 601381 tcaaatcctg cccccgcaac caaatatatg gttaaataag gagtgcccta agggtgcaac 601441 caaaataatc ctatacaaat atggtccggt agttcagttg gttagaatgc ctgcctgtca 601501 cgcaggaggt cgcgggttcg agtcccgtcc ggaccgccat taatgtaaac gaaacgatca 601561 tgttttcgtt ttttttgtgt tttcttttac tgtatcttct gcttggtgtc atagccaagc 601621 tttctttata tcgggaacat cttggatatt ccagcaaaat tcgataaact aggaagagca 601681 caaataggca taagcagggt tgaaaggagg ttttggttca tggatgaatt tgatttgata 601741 catagcatta ctccgcggac cattcaccat tcttccgttg atgtaggaat aggtgatgat 601801 gcagcgctct acactgcgaa acacggcgtt caggaaattg tttgtgttga tactatggta 601861 gaagacgtgc acttcaaatt acactattcc tcacctgaag atatcgggta caaggcgtta 601921 gccgttaata taagtgatat tgccgcgatg ggaggcattc ctaagtttta tctggtatca 601981 cttgcggtac cttcaaaatg gactgaatct gaaatcaagg cgatgtatga aggaatgaat 602041 gaactggcga aactatatca tatggatctg attggcggcg atacagtttc taccgctgac 602101 aaattagtcg ttacagtcac tgtaatcggt gaaattgaaa agggacaggc ctgtttgcgc 602161 agcttggcaa aaccgaatga tattgtgttt gtaaccggtg aaatcggttc ttctgcagca 602221 gggctttctt tattgctgga agagactaat cctcaaaact catctgtgga aacggattac 602281 tttatccaca ggcataaacg gcctgagcca agagtaagcg tcggcagatt atgctcgatt 602341 tttaaacggg cagctttaaa tgatgttagt gacggattgg ctagtgaact gaacgagatt 602401 gcagaagcca gctgtgtttc aattgaaatt gttgaaagca tgcttccaat tcattctgat 602461 ttgcctaagc ttcatcctaa ctggaaagaa tgggctttgt ttggcggtga ggattttgag 602521 ctgacaggga cggtttcaaa tgaggagtgg gaagtgttga agcaggagtg cgcagcgctt 602581 catcttccca ttacaaagat tggctatgtc agggaaaaaa caaaatctaa agtgatccta 602641 aaaacagatc aaacatcaat gatcttagag aaaaagggat ataatcattt taaataagac 602701 gggtgactcg tgtgaagcaa ttaaaatgga gaactgtaaa tccagaagaa acaaaagcaa 602761 ttgccaagct gacggcagcg tttgctaaac cgggagacgt cctgacatta gagggcgatt 602821 taggtgcagg aaaaacgact tttacgaaag gttttgcaga agggctggga attacacgta 602881 ttgtaaacag tccgactttt acaattataa aagaatataa cgatggcgta cttcctcttt 602941 atcacatgga tgtgtataga atggaagatg aaagtgaaga tttgggactt gatgaatatt 603001 ttcacggaca aggtgtctgt ctcgttgaat gggctcattt aattgaagaa cagctgccac 603061 aggagcgact gcaaattgtc atcaaaagag ctggtgatga tgagcgggaa attaccttta 603121 ctgctgtcgg gaatcggtat gaaatgcttt gtgaggagtt aagtagacat gacaatatta 603181 gcaattgata catcaaatta tacattgggc attgcgctgc ttcgagaaga cactgttata 603241 gcagaataca ttacatattt gaaaaagaac cactctgtaa gagcgatgcc tgctgttcat 603301 tcattgctga atgattgtga tatggcaccg caggaccttt ctaaaattgt cgttgcaaaa 603361 ggccctggtt catacacagg agtaagaata ggtgtgacgt tggccaaaac acttgcctgg 603421 tctttagaca ttccaataag tgctgtatca agtcttgaga cgcttgcggc aaatggccgg 603481 cattttgacg gtctgatcag cccaatcttt gatgctagac ggggacaggt gtacacaggt 603541 ctgtatcaat ataaaaatgg gcttttagag caagttgttc cagatcaaaa tgtgatgctg 603601 gcagattggc tggagatgct aaaagaaaag gaccgccctg ttttgttttt aggccatgat 603661 acttctcttc acaagcagat gatcgaggat gtgcttggaa caaaaggatt cattggaact 603721 gccgcccagc ataacccgcg cccttcagaa ttggcttttc tcgggaagga aaaggaagca 603781 gctgatgttc atgggcttgt cccggattac ttgcggctgg cagaagctga agcgaaatgg 603841 attgaaagtc aaaagtaggg tgataggatg aaaacaaaag cagcggtcag aaatatgcgg 603901 cttgaagata tagatcacgt atacgaaatc gaagcatcct cctttacgtc tccttggacg 603961 aaggattcgt tttatcatga gctgctggaa aatccgtatg ctcattatct cgtgattgaa 604021 aaggacggcc atcttgctgg gtattgcggg atttggattg tgatggacga tgcccagatt 604081 acaaatatag cgataaaacc agagtatcgc ggccagtctt taggagaaac gctttttcgc 604141 tcagctgttg aactgtgcaa agaaaaagac gcaaggcggc tttcgcttga agtgagggtt 604201 tcgaatcatc ctgctcaagg cttatataag aaattcggga tgcagcccgg cggaataaga 604261 aagaactatt atactgataa cggggaagat gcgttaatta tgtgggtgac gataaatgag 604321 tgagcaaaaa gacatgtacg tattaggaat tgaaacaagc tgtgatgaga ctgctgcagc 604381 tattgtgaaa aacgggaaag agatcatttc aaacgtagta gcctctcaaa ttgaaagcca 604441 taagcgcttc ggaggcgttg ttccggaaat tgcttcaaga catcatgttg aacaaatcac 604501 tttggttata gaagaggcgt ttcgcaaagc tggcatgacg tatagtgata ttgatgcgat 604561 tgcagtaaca gaaggtccgg gactggtggg agcgcttctt atcggagtga atgccgctaa 604621 agcattgagc tttgcatata acattccgtt agtaggcgtt catcatatag ccggtcatat 604681 atacgcgaac cgtcttgtag aagacatcgt gttcccggca ctggcattgg tcgtttcagg 604741 aggccataca gaactggttt atatgaagga acatggatca tttgaagtca ttggggaaac 604801 ccttgatgat gcggcaggag aagcctacga caaagtggcg cggacgatgg gattgccata 604861 tccgggtgga ccgcaaattg acaagctagc tgaaaaaggg aatgacaata ttccgcttcc 604921 tcgcgcatgg cttgaagaag gctcttacaa cttcagcttt agcggattga agtctgcggt 604981 gatcaatacg cttcataatg catcccaaaa agggcaagag attgctccgg aagatttgtc 605041 tgccagtttc caaaatagtg tgatcgatgt cttggtaacc aaaacggcgc gcgcggcaaa 605101 ggaatatgat gtcaaacagg tccttttagc cggaggagta gctgcaaaca gaggcctcag 605161 agctgcatta gaaaaggaat ttgcccagca tgaagggatt acgcttgtca ttcctccatt 605221 agctttatgc acggataatg ctgcgatgat tgctgctgct ggtacaattg cttttgaaaa 605281 aggaattcgc ggtgcatatg atatgaatgg ccagcccggc cttgaattga cttcttatca 605341 aagtctcacg agataatagc gtgagacttt ttatctgttt gttattaaca gacaattcac 605401 aatttatcca catatctgtg agtaattata gagatattga tggataaagg gctgaggtca 605461 ctgttaataa agtggataaa ttcagaatat tttgtggata gtgtgtataa agcgcttact 605521 ttgtttattt attaggggat gttctgtgga taaaaagcac ctctaaaaag aggtgcttga 605581 cttttttaat cttcttctgt ggatagttct tcccattcgg acaaaagaga ttccagctcc 605641 tgattaagct tctcattgtc tgcatggata gcttgtactt tttcatgatc ctgatagact 605701 tcagggtcac atagcaattc atcattgcgg ctgatgttct cctcaatggt ttgaacggtg 605761 gtttcaattt cttcaatccg acggagtcgt tggcgctctt tctttttcca ttctttttct 605821 tcctcgtagg aacgtttgga gtcagacttc actgtagctg gcgttttatc agtttcctct 605881 tgctgattca ttttctccaa ttcaagctgc tctgtttttt tctctgtata ataatcgtaa 605941 tctcccagat actcctctat atggcttgaa gaaagctcca atactcttgt ggcgattctg 606001 ttaataaaat atctgtcatg tgagacaaat aacagtgtgc ctggataatc aatcagcgcg 606061 ttttcgagaa cttctttgct gtctaaatcc agatggttcg tcggttcatc aaggatgaga 606121 aagttggctt tttgaagcat cagcttagct agagccaatc ttgctttttc gcctccgctc 606181 agtgaatgaa ctggtttcag cacatcatct ccggagaata agaaatttcc gagacacgtt 606241 ctgatttctt tttctgggag cccggggtac tcgtcccaca gctcatcaag gacacgttta 606301 gaggaagtca actcagcctg ttcctggtca taatagccga cactgacatt tgagccgtaa 606361 gaaattgttc cctgatctgg ttttagggtg tctattaatg ttttcagcaa tgtcgattta 606421 cctattccgt tagggccgac aagcgcagcg ctttctcctc ttgtgagcat gaatgacact 606481 tctgttaaaa gcggcggctg gttttcatag ctgattgtga gatcctgaac acgaaggact 606541 tcatttccgc tctgttttgt aatatcaaaa tgaaagtttg cggatttttc atcgccaagc 606601 ggttttgaca tgacatccat tcgctcaagc tgctttctgc ggctttgcgc ccttttggtg 606661 gtagaggctc tcgccagatt tcgatctacg aagtcctgca gctttgcaat ctcgtcctgc 606721 tgcttttcat acattttcag atctttttca tactgcgcgg ctttttggtc gagataagcg 606781 ctgtagttgc cgtgatactt tttgctttct gctcttgata cctcgtatac ctggtttact 606841 actttgtcca aaaagtagcg gtcatgcgaa acgatgagaa tggcgcctga atagccttgt 606901 aaataatgct caagccaggt aagcgtatca atatccagat ggtttgtcgg ctcatcaaga 606961 atgagcaaat caggctgtgt taatagaagc ttacctaaag ccagtcttgt tttctggcct 607021 ccgctgaggc tttgaacctg tgtagaatcg tcaaaatggc tgaagccgag accatgcagc 607081 acagatctaa catccgcttc atattgataa ccgcctttat ctttgaattc ctgctgaaga 607141 cggtcgtagg ttttcatgat gctttctaat tcacccgggt cagctgccgc cattttttct 607201 tccatagccc gcatttcctt ttccattgct tttaagtggt caaaaacagt cagcagctct 607261 tcttttatgg taagcttaga atccaagcca gtatgctggg cgagatatcc cattgtaata 607321 tctttcggtt taataatttc gcccttttca tacgaaagct ggcctgcgat aattttaagg 607381 agcgtggatt ttccggcgcc atttcttcct acaatggcga tgcgatcacg atttctgact 607441 tccagcttta tattgtttaa aatagtatca gcaccaaatg atttggacag ctgattaact 607501 tgtaagatca tcatattatt tcacctctgc tataataagt taagtgtagc ttatgaacca 607561 gaagtcagca aacaatacat tggccatata agacatagag aagaaaatag tgtatgatct 607621 gtttaaggag cgttttaata tgaatggatt ttctcatttt aatgaacagg gcagagccca 607681 gatggtggat attagcgaaa aatcttcgac tgtccgtact gcggcggctg tttcaagcgt 607741 acacatgaag aatgaagtgt acgagaaaat acaaagtcac gatatcggca aaggagatgt 607801 actggctgtc gcacaggtgg caggcattat ggccgcaaag caaacgtcga atatcattcc 607861 gatgtgccat ccgctttcat tgagcggggt agatatatcg tttgactgga aaataaaaga 607921 agcagaagtt atacttcata taaaagcaca ggtcaaaacg aaagggagta caggtgtgga 607981 aatggaagcg ctcacttctg catcggtgtg cgctcttacc gtttacgata tgtgcaaggc 608041 ccttgataag ggaatggtca tcggccctac tttcttgctg gagaagacag gcgggaaaaa 608101 cggtgacttt aaaagagaac tatccgagta taatttggag gaccaaaaat gaataaggat 608161 caatcaaaaa ttccgcaggc gacggcgaaa cggctgccgc tttactatcg ctttttaaag 608221 aatctgcatg cgtcaggaaa acagcgtgta tcatccgctg aactcagtga tgccgtaaag 608281 gttgattctg ccacgattcg gagggatttt tcctattttg gagctcttgg caaaaaagga 608341 tacggatata atgtggatta tttgctgtct tttttccgga aaacgcttga tcaggatgag 608401 atgacagacg tcatcttgat tggtgtcggg aacttgggaa cggcatttct tcactataat 608461 ttcacaaaaa acaataacac aaaaatttct atggcttttg atataaatga gagtaaaata 608521 ggaactgagg taggcggcgt gcccgtctat aaccttgatg accttgaaca acacgtaaaa 608581 gatgaatcag ttgccattct tacagtgcca gcagttgccg ctcaatccat tacagacaga 608641 ttggtcgcat taggaatcaa gggaatcctt aattttacgc cggcccgttt gaatgtgccg 608701 gaacacattc gaattcatca tatagattta gcagttgagc ttcagtcact ggtttatttt 608761 ttgaagcatt attcagtttt agaggaaatc gaatagaggg aaaggaggag cccaaatatg 608821 ccgatcggtc ctggaagcct tgctgttatc gcaatcgttg ctctgattat cttcggtccc 608881 aaaaagctgc ctgaattggg gaaagcagcg ggagacacac ttcgtgaatt taaaaacgct 608941 actaaaggat taacgagtga tgaagaggaa aaaaagaaag aagatcagta agttaggatg 609001 acacgaatga aagtgaatca aatgtcgctg ctggagcata ttgctgagct tcgaaaacgg 609061 ttgctgattg tagcgctggc gtttgtcgtt ttctttattg ctggattttt tttagcaaag 609121 ccgattattg tgtatctgca agaaacagat gaagcgaagc agcttacgct taacgcgttt 609181 aacctgacag acccgcttta tgtgtttatg caatttgcgt ttatcatcgg catagtcttg 609241 acctcgccgg ttattcttta tcagctttgg gcttttgtga gcccgggcct ctatgagaaa 609301 gagcgcaaag taacgctcag ctacattccg gtctctattt tgctgttttt agcgggctta 609361 tctttttcat attatatttt atttcctttt gttgttgatt ttatgaagcg gatttctcag 609421 gacttgaatg tcaatcaggt gatcggaatt aatgaatatt ttcattttct tctgcagctg 609481 acgattccgt ttggactgct gttccaaatg ccggtcatcc tcatgttttt gacaaggctc 609541 ggaattgtga caccgatgtt cttggcgaaa atcagaaagt atgcgtattt tacgctgctg 609601 gtgatcgcag ccctgattac accgcctgag cttctgtccc atatgatggt cacagtcccg 609661 cttttgattt tatatgaaat cagtatcctt atatcgaagg ccgcttatcg gaaagcacag 609721 aaaagcagtg ctgccgatcg ggacgtgtct tctgggcaat aataaaaaat ccatttctca 609781 tgcgagaaat ggattttctt tatttttggt tctttttgat tttaaatgaa aaggcgaaca 609841 tcttaaaaga aatgctgatg ttgtaagcgg cgaacaccat cagcaggatg gagtaaaatg 609901 accacatgct gcctggcgag cttgcggcaa gataagtaaa gatgcaccct acggcaaagt 609961 agatcattcc ccaaactacc gggtttctca taaaaataat cctccaataa tcaattgcat 610021 ttgtgtgctc tgctgttcaa ggtaattacg aacaggctca agctgcatga tgacgacgaa 610081 tgtattcatc attaaatggg cgaaaatcgg cacccatatc cgttttgttc tcgcatataa 610141 aaaggcaaag gtaaagccca ttgctgtata tagaaggaga tgcttcaaat cagcgtgaac 610201 aataccgaag ataaccgagc tgatcagtcc tgcgaaaaag aaattcgttt tttcgtacag 610261 cgcgccgaaa atgatttttc tgaagatgat ttcttctaat ataggcccga cgatggaaga 610321 aacgataatc atgagcggga ctgcctgaat gacatccaga atcgcttgtg tattttctga 610381 ttctcttccg atgccaaaaa cataatattc aatagagcct gctattcctt gagagaaaag 610441 ggcaatgaaa aaaccggcta tcgcccaaag gatagaaagt ccgattgagt ccttctgtcc 610501 gtttcgcagc gtttctttcg gaacggttct cagaatgagc agaacaacaa cgagacaggc 610561 gataaagctg ataacggacc ataatccttg tgcatgcagc atattttcat ctgtaggctg 610621 tcctccggca taaccgaatt taaataacaa gggaatcgcg attaatgcgg aaaactgcat 610681 gatgatatat gtcaaaataa taaaccaata ctgttttctc aaatggtatg tactcctttg 610741 ttaagtgggt ttcgttcatc tacagctatt gtaacataat cggtacgggg gtgaaaaagc 610801 taacggaaaa gggagcggaa aagaatgatg taagcgtgaa aaatttttta tcttatcact 610861 tgaaattgga agggagattc tttattataa gaattgtgtt agcactcttt agtgctgagt 610921 gctaaaatta catattcata ctattgagga ggttatttca ttgttaaagc cattaggtga 610981 tcgcgttgtc attgaactcg tagaatctga agaaaaaact gccagcggaa ttgtgttgcc 611041 ggattctgca aaagaaaaac cgcaagaagg caaaatcgtg gcagctggtt caggtcgcgt 611101 gttagaaagc ggagagcgcg ttgctttaga agtaaaagag ggcgaccgca ttatcttctc 611161 aaaatacgca ggtactgaag tgaaatacga aggtactgaa tacttaatct tacgtgaaag 611221 cgacatttta gctgttatcg gctaattctt aaataaacaa tacttaaaac atttgaggag 611281 gtcttgtaaa catggcaaaa gaaattaagt ttagtgaaga agctcgccgc gcaatgcttc 611341 gcggtgtcga tgcacttgct gatgctgtta aagtaacttt aggaccaaaa ggacgcaacg 611401 tggttctaga gaaaaaattc ggttctccgt taatcacaaa tgacggtgta acaatcgcta 611461 aagaaatcga gctagaagac gcgtttgaaa acatgggtgc taagcttgtt gctgaagtag 611521 ccagcaaaac aaacgacgtt gccggtgacg gtacaacaac tgcaacagtt cttgcgcaag 611581 caatgatccg tgaaggcctt aaaaacgtaa cagcaggcgc taaccctgta ggcgtgcgta 611641 aagggatgga acaagctgta gcggttgcga tcgaaaactt aaaagaaatt tctaagccaa 611701 tcgaaggcaa agagtctatc gctcaggttg ctgcgatctc tgctgctgat gaggaagtcg 611761 gaagccttat cgctgaagca atggagcgcg taggaaacga cggcgttatc acaatcgaag 611821 agtctaaagg cttcacaact gagcttgaag ttgttgaagg tatgcaattc gaccgcggat 611881 atgcgtctcc ttacatggta actgactctg ataagatgga agcggttctt gacaatcctt 611941 acatcttaat cacagacaaa aaaatcacaa acattcaaga aatccttcct gtgcttgagc 612001 aggttgttca gcaaggcaaa ccattgcttc tgatcgctga ggatgttgaa ggcgaagcac 612061 ttgctacact tgttgtgaac aaacttcgcg gcacattcaa cgcagtggct gttaaagctc 612121 ctggtttcgg tgatcgccgt aaagcaatgc ttgaagacat cgctgtcctt actggcggag 612181 aagtcatcac agaagatctt ggccttgacc tgaaatctac tcaaatcgct caattgggac 612241 gcgcttctaa agttgtcgtt actaaagaaa acacaacaat cgttgaaggc gctggcgaaa 612301 cagacaaaat ttctgcccgt gtgactcaaa tccgcgctca agtggaagaa acaacttctg 612361 aattcgacag agaaaaatta caagagcgtc ttgctaaact tgctggcggc gtagctgtca 612421 tcaaagtcgg cgctgcgact gaaactgagc tgaaagagcg taaacttcgc atcgaagacg 612481 ccttgaactc aactcgcgca gctgttgaag aaggcatcgt atccggtggt ggtacagcgc 612541 ttgtaaacgt atataacaaa gtcgctgcag ttgaagctga aggcgatgct caaacaggta 612601 tcaacatcgt gcttcgcgcg cttgaagagc caatccgtca aatcgcacac aacgctggcc 612661 ttgaaggatc tgtcatcgtt gagcgcctca aaaacgaaga aatcggcgta ggcttcaacg 612721 ctgcaactgg cgaatgggta aacatgatcg aaaaaggtat cgttgaccca acaaaagtta 612781 cacgctcagc tcttcaaaac gctgcgtctg tagctgcaat gttcttaaca acagaagctg 612841 ttgtcgctga caagccagaa gaaaacggtg gcggcgcagg aatgcctgat atgggcggca 612901 tgggcggtat gggtggaatg atgtaataaa gggatattaa cccttataca tcaatgtttt 612961 aaccgtctta aaaaactaga caaagcgtga ataaaaaaag agaaggtctt tcatcagttt 613021 actaaactgt tgggagacct tttctccata ttagcggtca tatgagcata aatgtccatc 613081 gtcgtattta tgtccgaatg accaaattgt tgctggattt ctttaatgcc tactcctgcc 613141 tcaattagta aggaggtatg ggtatgccta aaagagtggg gggtgacatt ctttttatcc 613201 cagctttttt gagcagccgt ttaagtctag tctcaataac ctttcttaat tgcggatgac 613261 catcctcccg ctcaaaaata aatgatgagt cttgataaat caatctattt ttaagcttaa 613321 tttcattttg ataaatttta ttttttttta gtagattgac atcgtttcat caattcgaac 613381 gatatcaaca gatcctgttg ttttaggtgt tagcaattgg tatttttcaa tttgattgtt 613441 aggggtgtat agggtctttg tgacctggct tatcattgaa atctgtccat tttaaagcaa 613501 gaagttcacc aattcttagg tcggtctagg caagtacggt aaagaccaaa tggtccattt 613561 ctagcccgtc agattgagcg agctttagaa aatgtgtcag cacctctttt tccaatgctt 613621 tgttgcttct tgggtaattg aaaatcccca gttgggttca ttttaataat cccttgagtt 613681 ttagcttttc ggaaaatcat acggccgcag gcatgaatac ctcccaaaca attgtgactg 613741 tattgctcgt tcagttctaa cgtgcggtct tcatacattt ttttgtgttt tgctaatcgg 613801 gtattgaccc aatactgcga taaaatgcat cattttcttt tcactggccc gtacactgct 613861 tatttttacc ccactccggt tgtaaatctt aagccaacct tttgcaaatg ttttgaaggg 613921 catatctgac tccttaataa aagtcccgtt gtcgttttgg agttctacgt gacgggctgc 613981 tactggggct tctttctttg ttttaaatct tcctttggat atttctagac gttttttggt 614041 taaagggtca atgcctagta gatatgataa ctccacgtct taccgcattg cttgagtttt 614101 gccatttatt tgtccctaac taattttttt tcatcaaatt ggtctttaag tgagtttaat 614161 aatttttgtt tctctcgact ggtcaataat tgcccttcat atttcaaaag attggataaa 614221 tttgagatgg aatcaatcct gatggatggt accgtagact ttaataagaa acgaaaggcc 614281 aactgcgact tcagttggcc tttcctattt ataataaaga aattgagtga gattgctgac 614341 agaactacgt actactcgtt ttctttagtt gcccttgcta atcgttcaac ctctccccga 614401 atcccaatcg caggctccca cgaatcaatc aaacgaatcg ccttctgatt agattccacc 614461 gctttcgttt tctctccttt acgatacaac agctgcgcca ttccgtagtg atagtagatc 614521 agttcaactt gattggcgtt atgtttgtca tagagcattt gctcaaaggc ttcttccgct 614581 ttttcaaact gatcacattt cacgtaagcg acacccagat tgaaataggc ttctatcgtt 614641 ttttcgccgc cgtatgtgga gctgatttca tttgccgctt cgtataattg aatggcttct 614701 acatgataac ctctcgcaaa gcttaagtca ccgcgaacca atagaactct gtgttgaatg 614761 gtaggggaaa tcggttgatt ttcgatttcg tttaaaattg tctctgcttt ttcctgttgc 614821 ccgtctttta aaaacagcct tgctttgagt gcatgtcccc aaacctttag atcataggca 614881 tcgtgagcgt ctgattgttc aagaatcttc agcccggctt ctatttgctg aagcgctccg 614941 tctaaatcat tgacttccat caatgcccag cctgaggtgt cgattcggaa gtacgcttct 615001 cgtgtgtgtt ggcctaagtg atgggcggcg tcggccgctt tgcgtccgta ttcgattcgc 615061 aggggcaggt tgattctgct tagaaaatgg ctaatgcggg tgatgagttc gattaggatt 615121 tctttttgtt cagtttcact tgcccattgg atgaccttta agatgtttgg ccattcttgt 615181 ttcatttgat ctaagttccg tcccagcagg tagctccaat agatagagtt gggctgttcc 615241 cgctttaaat gggtttcggc ataatcaata taatagtgcg cccagcgatt gcgggcttct 615301 ttttcatatt cgtgctgttc ggacaagtgc tgttctccgt aagcgacaac ggtttggtgc 615361 gctaagtatt gtgtcctgcc ttggcttcgt tccggctgaa tcagcgcata tgaccgcatt 615421 tgttccatag cgtaatgaaa acggcgggcg tctaatccgg ctgctgccgc caggcttttt 615481 tcatcaggcg gcttgctgaa aaagcaaagc gtctgccaga gctttcgcgt atcttcattg 615541 catctatccc aggtgcggcc aaagaggaat tcaaacaatt ccagcagtga gtagcctgct 615601 tttccaagct catgaatcag ctgctgagcg gggatgtcat cgtctgacat ataggcaatg 615661 ctgagtgcca tggctttcgg gtttccggca gtcgctgaaa tgaattcgtt tttcaggtca 615721 gatgatagat gtaacagctg ctccagcttt tcccgtttac gtgggaggtt gcatgtttgt 615781 aagcagtgat gcacttcttg ttgaaaaaat tcgtgggcat ctgtttggtc aagaccgctt 615841 agctgaatgg ctgtcatttc tccgaagctt tcccgataag tttgctttac gttttcccgc 615901 gctgtaagga gaacttttac gccttgcgga aggctggtga taaattcatg aatgtcacgt 615961 tctgcagtat caatgctgtc aacgatcagc aggatcggtt tttctctagt gtaattggct 616021 aacgcattgc ggacgacaaa ccgttttaca ttgattgatt tatcgatttg ttctttgcgt 616081 ccgagctgat aggcgatcgt atttaaaaaa tcgctaaagc ttaatccttt ccaatcagcg 616141 ctgacccaga tgatgctgtt gaatgccggc caaactgaag tatcgtcgac acaggaatag 616201 gcggcttcaa gagcaattgt ggtttttccc atgccggccc agccggtgat taaacagact 616261 ggtgatggag aaagcatcca ttgccgtatc gcttccatat caaagctgcg tccgataaag 616321 cgtccggacc agcgtgaggg taaattatgc gtgatgggct gttctgtaag cgcattcgtt 616381 tcttggccgg gtctgtcatg aaacagccgt tttactacat tttcaatttc gccttcactc 616441 ggagccccga ataatccgtc ttttcgcagt attttcgctt ttttcaaaca ggatgctgcc 616501 catacaggca atgcgggttt gatgactggg atagtggtgg cttccagcaa gtcggtcaac 616561 cactcgatat ccaagtcggt cttttcgaga atgatccaga tcattccgaa cagttttccg 616621 tcgtcgattc ttccgggaat gtagtttgcc cccatctgtc cgatccagct tttgatcgtg 616681 tttggggaga ctcccagctg gagtgcgatt ttatctatgt aagactgtcc tgttttttca 616741 ttctttttcc ttctgacttt ataatcagga tgaagtttta gcgttttgac gccaggtgcc 616801 agcatttgtg caaattgttt tcggttttca agttcagcca taagcctgca cctcctatta 616861 gtactatttt atcaatccag cgttttttgt atatgaaaaa ataaaagtac agtgccgctg 616921 tccttttata cagcaggaaa ggctgttgaa cgtgttaaaa agcagataaa atgggggcag 616981 taacagagaa aacaaaaatg tatgcactta cattttattt tctaaagaaa ggaacttgcc 617041 aaatgactca cacagtacct caaaacatga aagcggctgt tatgcacaac acaagagaga 617101 tcaaaattga aacattgcct gtgcctgata tcaatcatga tgaagtgttg attaaggtga 617161 tggctgtcgg aatttgcgga tctgatctgc attactatac aaatggccga ataggcaact 617221 atgttgtgga aaaaccattt atccttgggc atgaatgtgc gggtgaaatt gccgctgtcg 617281 gatcatctgt cgatcaattc aaggtgggag accgcgtcgc tgtagagccg ggtgttacgt 617341 gcggacgctg tgaggcgtgc aaagaaggac gctataatct ttgcccggat gtacagtttt 617401 tggctacacc gccggtagac ggtgcgtttg tccaatatat taaaatgcgt caggactttg 617461 tttttttaat cccagactca ctttcttatg aagaagctgc tttgatcgag ccgttttctg 617521 tcggtatcca tgcggcggcc agaacgaagc tacagcccgg atcaacgatt gcgattatgg 617581 ggatgggccc tgttgggtta atggctgttg ccgcagctaa agcatttggg gcaggcacaa 617641 tcattgtcac cgacttagag ccgctgcggt tagaagctgc gaaaaaaatg ggagcgactc 617701 acattattaa tatacgtgaa caggatgcac ttgaagagat taaaacgatc acgaatgata 617761 gaggcgttga tgttgcttgg gaaacagcag ggaatccagc ggcattgcaa tccgcactgg 617821 cttctgtgcg ccggggcgga aaattggcga ttgtcggttt gccttcacag aacgagattc 617881 cgctcaacgt gccgtttatt gcggataatg agattgatat ttacgggatc ttccgttatg 617941 ccaatacgta tccaaaggga atcgaatttc ttgcttcagg cattgtggac acgaagcatc 618001 tagtaacgga ccaatattcg ctggagcaga cgcaagatgc gatggagcgg gcgcttcaat 618061 ttaagaatga atgtttaaaa gtgatggtgt atccaaatcg ctgagtgaac agggaggatc 618121 ttcgtattct ccctcttgtt tactggaaat gaaaacggat tcttggggtg ggaaatgatg 618181 attggaacag aaaaagtaac ggcattgaag gcgaagcatc agtcaaaatc cagcaccggc 618241 ctgtcctggt ttgaacgaat cggttatgga ttcggcgata tgtcgtataa tattatcttt 618301 cagtttgtaa acgcatactt attattttat tatacagacg tcggcggcat tcagcctgcg 618361 gtaatcgcaa ctttgtttct tgttgtgcgt gtgctggatg ctatttttga cccgatcatg 618421 ggattgattt tagataaaac gaatacaagg tggggaaaag caaggccata tttgctgtgg 618481 gtggcatttc cttttgcgct attcacattc ttatgtttca cgacgcctca tttcggtgag 618541 accggaaata tggtatatgc gtatgtcact tatattctgc ttgggatgtc ctttagtatg 618601 caaacgatcc cggtgaacag cttaacgggg cggatgacga attcggtgga ggaacgaacg 618661 gttctgacca caacccggat gattttggtg tatatcggca ttcttttatc catttcctgt 618721 gcgacaccgc ttgcaactgc tatcggagga gaggatcagg cgtttggatt tcagatgacg 618781 gcgctcatct atgcggctgt cagcatcgtt ttgaatctat ttagtttctt tactgtacgg 618841 gagcggattc agcctaaaaa gagaaaaaaa caagggatca aaaagacgtt atccgtttta 618901 ttcaaaaaca aacccttgct catgttaatt tcatcatttt tggcttttgc gatcgggttt 618961 aatattaagc tcagcacgat ggtgtattat tttacgtata acgtaaacca taaagagttc 619021 gtgtttatgg gcaccgtttt atttttcggg gcagcgctga tcagcaattt gtttattcct 619081 ttcttttctg agaagtgggg cagaaaacaa gtcatgatta tcacggcagc tctatcgctt 619141 atttcttatg ccggcctgca ttttacgccg tattcttcaa ttccactcat tttcatttgg 619201 cttttcgctt cgggattttt cacaacgcct ttaaatacgc ttgcttgggg aatggttgcg 619261 gattgcgtcg attatgcgga atggaaaacc ggaattcgcg cggatggtgt tgtgatttcg 619321 agcatgagct ttattaataa gctgggtgtt gcgttagccg ggtcattttc ggccatttat 619381 ttaggaatcg ccgggtatgt ggcgaataca gaccagacag ttgcgtcgtt gaatgcgatt 619441 aaaaatatga atgctttgat tccgggattt ttcattttgc tttctattat tcttatcgcc 619501 ttctatcctt taacggaaaa aagatataaa cacatcatct ctgagctgga gcaaaggtct 619561 gcgagataaa tagatgtaaa atttttaata ttcaatgttg tatttatggc aaaaagtaat 619621 atactgagac tgtaatctag actttataaa tgagtgtgat aatatgcgta gtcattctgt 619681 agtttgtatt ggggaattgt tgattgattt cttttgtacc gatgttgacg ttgatttaat 619741 ggaagggcgc caattcctga aaagtgccgg cggggcaccg gcgaatgtgt cggcagcgat 619801 tgccaagctg ggcggagacg ccgctttcag cggaaaagta ggaaaggatc cgtttgggta 619861 ttttctgaag cgaacattgg acgctgtaca tgtcgatacc tctatgctgg tgatggatga 619921 gaaagcgcct acaacgcttg cttttgtttc attaaaacaa aatggagagc gtgactttgt 619981 ttttaataga ggcgcggacg ctttgtttac gctggaggac attgaccagg aaaaactaaa 620041 cgaagcgaaa atccttcatt tcggctctgc gacggcactg ttatcggatc cgttttgctc 620101 agcctattta cggttgatgt cgattgcgaa agacaatgga cagtttattt cgtttgaccc 620161 taactaccgt gaagatttat ggaggggaag agtctcagag tttgtaagtg ttgcgaaaaa 620221 agcgatcgct gtaagtgatt ttgtgaaagt cagtgacgag gaacttgaga ttatcagcgg 620281 tgtgaaggat catgaaaagg gagttgcgat ccttcatgag atcggagcca acattgtcgc 620341 tgtgacactt gggaaaagcg gaacgcttct ttccaatgga aaagaccgtg aaatcattcc 620401 aagcattccg gtgacatcaa ttgactcaac aggggcggga gatgcttttg tcggtgcggc 620461 tttatatcaa ttggcaaaca cggatcagat tcaatctgta gatgctgatt ttgtgaaact 620521 gcgtgagatt gtggcgtttg ccaataaggt cggagctctt gtgtgcacta aaattggagc 620581 gattgatgca ctgccgagtt tggatgagat tggagtttct ttgtaaatca ttgaagatgt 620641 ttcttgaaag tctttggact tttgggggca tcttttttta ttgcttacat ttttgttcag 620701 gtaaaaagtt gtatattttt tgtttgaaat gtcatttttt attaaaaaag tgaaactttt 620761 aacgataata aatagtatat gtaacaaggg ttaccgaatt agctttagga ggaacgatat 620821 aatgagtata attggaagat ttaaagatat tatgtctgcg aatatcaatg ctttattgga 620881 caaggctgaa aatccggaga aaatggtaga tcaatattta agaaatatga atagcgattt 620941 ggctaaggtt aaggcagaaa cagcagctgt tatggctgag gagcagagag caaaaagaga 621001 atatcacgaa tgccaggcgg atatggaaaa gatggaaagc tatgcaatga aggcgctgca 621061 agccgggaat gagagcgatg cgagaaaatt tcttgaaaga aaaacatctt tggagtcaaa 621121 gctttctgag ctgcaggcgg cgaatcaaat tgctgcaacc aatgccgcac agatgagaaa 621181 gatgcatgac aaattggtat ctgacattgg agagctggaa gcacgcaaaa atatgatcaa 621241 ggcgaagtgg gcagtagcga aaacgcaaga aagaatgaac aaactgggcg cttctgtttc 621301 aagtacaagc caatcaatgt ctgcattcgg ccgaatggag gacaaagtaa ataaggcact 621361 tgatcaggcc aatgcaatgg ctgaactgaa cagcgctccg caggatgata tggctgatct 621421 gtctgcaaag tatgacactg gcggttcaag ccaggttgat gatgaacttg cggcgttaaa 621481 agcgaaaatg atgctcgata agtaatacat aggaggccgc agctttcggc tgcggcgtca 621541 ttttatcata aaatgtgaga gggaacggta atgataatat cttataagtg tccgaactgc 621601 ggcagtgata tggcatttga cagtgaaacc ggctcgttat cctgcagcag ctgcggaaga 621661 caggacaata ttgaaagcct tccgaaagaa aacattgcgg cacggttttc tgatgatgaa 621721 gcaaaagaat atcaatgtaa aaactgcggt gccgttttga tcacggaagc tgaaacgaca 621781 gcaacgacgt gcagcttctg cggaggtgct gcaatacttg ccgatcgttt atcaggacat 621841 ttggcgccgg cgaaggtcat tccatttaca atcagcaagc aagaagcgga gcaggcattt 621901 cgaaagtggt gcaaaaaagg ccttctgaca ccaagaggtt tcatgtctgc tgatcgtatc 621961 aaaagcatca ccggcatgta tattccattt tggatgtttg atttaaatag tgaagtacag 622021 gtgagagcaa actgtaccag agtccatcaa tatgaagaag gggattatat ttgcacggaa 622081 acagagcact ttgaagcgtt tcgtgatatc aatctcgatt atttgaaaat ccctgtcgat 622141 gcctctgaaa aaatgaaaga cgaattaatg gacaaattgg agccttattc atacgaagag 622201 ctgaaggact ttcaaacggc atatttggcc ggttatattg cggaaaagta caattatacc 622261 gatgaggagc tttttccgag ggcaaaagag aaaatcagca gttatataga ttcatacatc 622321 cattctactt tttccggata tacgtcagtc aatgtgaggg acaaacatat tcacacgaaa 622381 aacgtgaaca gcttttacgt tttgcttcct gtttggatgg tcagttacga ttatgaaaga 622441 gcggagcata tctttgcgat gaacgggcaa acaggaaagg tcgttggaaa gccgccgatc 622501 agtcgaggaa aagtggctgc atggtttagc ggaatagcag gcgggacatt tcttgcgttg 622561 aagctcgtct cattgatgat gggaggcgga ttttgatgcg tggatttttt gggaaagcga 622621 tctttgttgt gctggctgtt ttcatcatga tgcctttact gggtatcgaa gcggtaagag 622681 cctctgaatt gcagcagcat gtgtacgatc gcgctcatct attgtcaaaa gcggagatcg 622741 gaaaacttga atctctctcg gcaaagctgg gtgcaaagag ggacactgat ttcatcatta 622801 ttacgaccaa aagcacaaac ggtgaagata ttgcagacta taccggcgat ttttatgatc 622861 gttacggaaa aggcagtaca gccattctga cgattgatat gacaaacaga gaagtgttta 622921 tcgcaggctt taaaaaagcc gaacagtatt tggacaacag caggctcaat agcatcagaa 622981 atacgatttc atctgattta tccaatgaaa attattttga agcttttgag acatatattc 623041 agctttccta taaagatatg ggcataaaac cgggagtaaa ccctgacaac atattcttta 623101 catggtggtt tcagctgatt gctgccatcg cagtcggggg aattgcggtt tcaatcatgc 623161 tttatcatgc aggcggcaaa gtaacggtta atggaagtac atatatggat cagcgtacgt 623221 ctgatgtgat tgatcaatac gacacttata ttagaacgac tgtaacaaga gaaagaaaac 623281 catcagataa agacagcggc agcgatggcg gtgttacgaa aggcggcacg tcatacagtg 623341 ggagccgggg cagtttttaa atgtaagaaa tagagaaagg gagaggcgta atgtcgtttt 623401 tcagaaatca attagcgaat gtagtagagt gggaagaatt tagagatgat atgatttttt 623461 ataaatggaa caatcgtgaa atcaaaaaag ggagccgttt aatcattcgt cccggacagg 623521 atgctgtctt tttgaacaat gggcgggttg aaggagtctt tcaagatgat ggcgattatg 623581 atattgaatc agaaattatt ccattccttt caacgttaaa gggctttaag tttggcttta 623641 acagcggcat gcgagctgag gtgctgtttg tcaatacgaa ggaatttacc gtaagatggg 623701 gaacaaaaca ggcgataaat attccggcag cgggaatgcc aggcgggatg cccattcgcg 623761 caaacggcac atttaatttc aaggtgcagg actatatcag cctgattgat aaaatcgctg 623821 gcgtgaaaga tcaatatttt gtagaggata ttaaaacccg tatcatttct attctggatc 623881 agcttctcat gaagtggatc acaagagaag ggaaagatat gtttaatctt caagcaaacg 623941 cttttgatat tgccaaggga attcaagagg acttagatat gcaattaata agcgacggga 624001 tgacggtcac tggttttcaa atcatgagct ttaattatcc tcaagaggtt caagatatga 624061 ttacaaagaa cgcttcctac ggtatggttg gggatgtgaa cagataccag caaatatcaa 624121 tgacggatgg aatggcatcc ggaaagatga gcggaagcgg agcggcttcg gatatggctg 624181 gaatgatgat gggaatgaat atggccaatc agatgatgaa ccaaatgaat cagaatcagc 624241 aggcacagtc atcaggccca cagtcaactg gcagcggaag caaaccgaat ttctgtccaa 624301 actgcggaac aaaaacgggc gaagccaatt tttgtccgaa ttgcggccag aagcttgtat 624361 aagaatcata cagtgaaaag tccggagtga tcagcactcg ggactttttt atttaggaga 624421 ataagcatta cctattgctt gctcctgaac aggccatttt cgagcccccg cttggataat 624481 tcccagcagc aattgacgac gttcctttat tgaattgacg gcaatttgaa atgtttgctt 624541 tgataaagcc ggtatgcctg attgttgaag ctttgagatg tctggttctg gcggcgcttg 624601 ttctgcagga tggatatagg cagtatgaac ggtatccaga tagtttttga tacttgagcg 624661 cgcttctttg atatgaagct gattcggctg atattgttca ggaattccgt atttgaaaat 624721 ggttagagcc tcatccaata cagcaacagc tataatggat gattcctgat gctgcgtgct 624781 gtggtaaaaa tgaaggatgg ggaaggcgtt atgctgagcg gtcagctttc ccagttctga 624841 tgaggcagcg acaagaagaa aatcaatgtc gtgaaaatct ttgccattcc atgcattatg 624901 gacgatttca gttccgtcat gccctagact taatacactt tgggcaaagg agcgtttttg 624961 attaaccgca ctcaagacgg aaatcaaata cgtgacagaa aatgtgatgg taagcagtcc 625021 ttgagctgtt tcaataatcg tgacaagctt ccataggcct ccgttcggag cgaggtcgcc 625081 atttcctaat gtaaacatga catagccgga aaaataaatt cggtctgacc aggaagccgg 625141 ttcttttgat tgagtttcca taagtgagtg agggtcactc gagtaaatca aaacccaccc 625201 gctccaaaat agactgatcc atatcactaa cgtcaggcat aacagcagag gaccagccat 625261 acttagaacc tttgcgtggt caccgctgat tttgcggcag cccttccaca gccaggcaga 625321 caggcatctt gtgatcgggc cggcaccgct ctctaaccat aacgtggtcc ataaaaaatc 625381 aatcatcccc gctgtcaata ataaaaggcc tgcaatgata taaccctcat tcattttggt 625441 tgcctccctt aagtcagcct tcttttattt tcttctctat ttccttttat cctgagtctg 625501 aaacaattga acgaatgttt gattttacag agaaaaatag gtgggagtta cccaacactt 625561 actcattttt caatatgaac agaaaatcac aagatttttg acttgattca cacattttca 625621 tgaagaaaaa cgttcatttt ccccttgaat tggtgatttt ccttttatag agtaaaaaat 625681 tttcagaaat ttatattgac tgaaagcgtt tttataatta tgataatatc agatataaca 625741 aaaatgtcac tataacatca ctacaattga actattaagt gactaataaa taccaaatga 625801 acgaggttat gcacaaagaa atgaccattg ttcttttaac gagaaatgaa atcgcttcca 625861 tagggattga catgctaaga agaagggaag gttatgaggt tattggataa aaacatgaac 625921 aactattttc tgaagcctgc ttacgaaatg tgaggaaggc agcagccctg gaataagttt 625981 ttgacatacg cattttgaaa aagactgggg gaaacagtat gaataaacaa ggaaatcaaa 626041 tgtcattttt acgtacaatt attttagtct ccactttcgg cgggcttctt tttggctatg 626101 ataccggtgt gctcaatgga gctttgccgt atatgggaga gccggatcag cttaatctca 626161 atgccttcac agaaggcctt gtcaccagtt cacttctttt tggagcggca ctgggtgctg 626221 tgtttggcgg caggatgtct gattttaacg gccgccgcaa aaatattttg ttcctcgctg 626281 ttatattttt tatttcaacg attgggtgta cgtttgcacc aaatgttacg gtcatgatta 626341 tttcccgttt tgtgctcggt attgcggttg ggggtgcatc cgtaacggtg cctgcctatt 626401 tagcagagat gtctcctgtg gaaagcaggg gacggatggt gacgcagaac gaattgatga 626461 ttgtatcagg acagcttttg gcctttgttt ttaatgcgat ccttggaaca acaatgggag 626521 acaactccca tgtgtggagg tttatgctgg tcattgcgtc acttccagcc ttgttcctgt 626581 ttttcggcat gatcagaatg cccgagagtc cccgttggct tgtttctaaa ggaagaaaag 626641 aagatgcttt gcgtgtattg aaaaaaatca gggacgaaaa acgggcagca gctgagctgc 626701 aagaaattga attcgctttc aaaaaagaag accagcttga aaaagcgaca tttaaagatc 626761 tttcagtccc atgggtgcgc cgtattgtgt ttattggatt agggattgcg attgtacagc 626821 aaattacagg tgtgaattcg attatgtatt atgggactga aattctaaga aattccggtt 626881 tccaaacgga agccgcttta atcggaaata ttgcgaatgg cgtgatttcg gtattggcaa 626941 cattcgtcgg aatctggctg ctgggaagag tggggcgccg gccgatgctg atgacaggct 627001 tgatcggtac gacaacagca ttattgctaa tcgggatatt ctcacttgta cttgaaggat 627061 caccggcact tccgtatgta gtcctgtcat taacggtcac atttcttgct tttcagcagg 627121 gcgccatttc accagtgact tggctgatgc tatctgaaat tttcccgctt cgccttcgcg 627181 gactgggaat gggtgttacg gtattctgtc tgtggatggt gaattttgca gtcagtttca 627241 cgtttccgat attgctggca gctatcgggc tgtccacaac gttctttatc ttcgttggat 627301 taggaatttg ctctgtcttg tttgtgaaga ggtttttgcc ggaaacgaaa gggctttcgc 627361 ttgagcagct ggaggaaaac ttccgcgctt atgatcacag cggggcaaag aaggattctg 627421 gggctgaagt gattggataa tttaaaaaag aatccgcacc cgagtgcgga ttctttttgg 627481 tttcaaatta gttaggtcta acaaggattt tgacttggct tttctcttta ataagagccc 627541 cgaagccttc ctcgatcaaa tcatctagta cgattttttt cgttacgagt ttgtcggctg 627601 agaaatagcc ttctttcatt aatgacaata cagccgggaa gatgtcgcgg tatccgataa 627661 ttccttttac tgtacgttct ttgattacga tatcgttcgg atggatttca gcaccttttt 627721 cccaaatgct gacgatgacg gtttcaccgg caattgtagt ggactggatg gcttgtcgta 627781 acaccactgg gacaccagtg acttcgaatg ctacgtcaac accgcctcct gtacgttctg 627841 caatctcagc gactacatcg tctgttttag acggatcaac gatgatcgcg ccaagctcct 627901 cagctttttg ctggcgttca ggagaaagct caacagcgta aatatcagtt gcaccggcag 627961 ccttcagcgc ttcaatgaca agaagtccga tcgggccgca gccgaataca gccgctttgt 628021 cgcctgcttt gagtttgctt gagcggacag cgtatagagc aactgcagaa ggttcaacga 628081 gcgcgccttg ttcatatgat aattcatcag gaagtttgaa caaaagctct tcatccacag 628141 agacgtattc agagaaaccg ccgcctccgc cggctaagcc gaggaatccc atttgttcat 628201 caaggttgta ggcgccttgg tggccgtgtg tagcaaaaat cggctcgact acaacgcggt 628261 ctccaacttt ataattttca acgccttctc cgacttcgac aacttcaccg gagaattcat 628321 gccccattgt gacaggtgcc gtttcatttg ttaatgggtg cggtttgtca accggaataa 628381 agatcgggcc gcccagatat tcgtgtaaat cacttccgca gatgccgcac catttgactt 628441 tgatctttac ttttcccggc tccgtttttg gctcttcgat atgttcaata cggatatcct 628501 tttggttatg ccatcttgct gccttcatgg attaccactc ctataacttt tgatgtgagt 628561 aattccgcac cggtcaatat gaactgttca caaaatcgcc atttttaaaa ccaaaaaaga 628621 aatgaaattt ttatataata taatctacgt ttttttgaaa aaaagaaact ttaaagaaaa 628681 aagggtctcg cacactcttt tttctttata tgagagtatc aatcgtttac atagctatga 628741 atttggtttg aacaatacgg taatggttcg ttcatattga atgcgacaac tactctatca 628801 ataattataa ctctaatact gctattataa taggataatc ttccatggtt tattttagca 628861 gaggtaactt ttttgacttt gtaacattac tgtaaggata ttgaaataaa aaatagctgg 628921 ttgatcgtgt ataatcttcc tagatgttaa caaacagggg gacgaaatgt tgaagaaagt 628981 cattttagcc gcttttatct tagtaggaag tactttggga gcttttagtt tttcatcaga 629041 tgccagtgcg aaacatgtga acggaaatat tacttggtat aatggagtcg ggaaaaaagg 629101 ctcttcaggt aagaaacttg gacattggga ttgtgcgacc aaaatcggat ttgatgttcc 629161 tagaaacggg acaaaaatca gagcttatgc aaaagcgaag cctaaaaagg tgattacggt 629221 ttataaaaat gatgttggca gaatgcctaa tgcagtgctg gatgttagcc ctaaagcgtt 629281 taaagcgctt ggatacccat taagcaaagg taaagtagcg gggcattaca gctattaatg 629341 tacatatata atctggaaag caagaagtca cattcttgct ttttctattg gtggagataa 629401 aagatgaaaa aaagaatcat attattatta gcagtgataa tagcggcagc tgccgcgggg 629461 gttgcgtttt atgttgcaaa ggataaaggc catgagaagg ctgctgatgt ttcagtcaat 629521 accgaaagcg gtgatgagct gctggtttca attacagata cggatctgct gacaaagtat 629581 tatgaaaatg acaaggtgat ccatgaggag aagctgacca gctatccggc atttgccttg 629641 gatcaaaaac agcaggtgct ctattatacg ggcaataatg aacagaatga aatgaggctt 629701 tttaaattgg atctgaagtc tcataaaaaa acgatgcttt ataaaggcgc ggagagtgcg 629761 gacagtttat ttttatcaaa ggaccgttca accatctatt tccgcttagg aaaagcggac 629821 gaaagcaatt ttcgaatcgc cgcttttgat ctgaagacga aaaagtataa aaatctttat 629881 cctgccgcta atgatcagga tgacaccgtc agcagcttct tttataacca aaaaaacgat 629941 tcatttgcat tgcttcatta ttctgtagaa gaagactaca agaaaacaga tgaagcaaac 630001 gaaaagggca tcgaccctga accgacaacg attcattttg cggaaggccg ccaaaataaa 630061 tttaatgagc tgaaaagcct gaaccaattt atcagcgata ttgctgtttc tgatgatgat 630121 aaacgtattt tattcacatc atatacgcaa aaaggaacgg agcaaaccgc ttctattcaa 630181 atgctcaatg cggatacgaa aaaatatgaa agcatcatct caaatcaaaa atcatttaag 630241 ctgttaattg acgcacagcc tcagttttct aaggatggga agaacattta ttttcttgcc 630301 gaagccaagg gggctaaaaa gctgaaggac gaaacagggc gtgaagctaa ggtgcggacg 630361 atttattcct atagccttga gaataagacc ttcaaaaaag tatgggaaaa tccgaacggc 630421 atcatcaaca gcttttttgt gattaactaa taaaaaccac tcggcatgag ctgagtggct 630481 tttttaatgg atgaggtgca gggctaatga tccgagccat ttaaagatat gaatcagagg 630541 taccgacaaa aacagaagtt caacatatga gttcattgca acattcagct ttttgaacgc 630601 agctcttttt ttcaagtctt tttgctgctg gtttgagatc acgttatcac tcctcttata 630661 tccatattat accattaaaa cagacaaaaa agccctaaac gtttacagtt ttgggcttct 630721 ttcttcgtat ttggcctctt gcaatgagag gcttttattc tgaaatatag aattttgtct 630781 ccgttcgggg tttgtttgct tgcgggagac tgcatttgtt atagggaaga actagcttgt 630841 tttcgtttgg ctgttgtttt ggagattcac taatgaacgg atgccgtcga ccattttact 630901 tccgcacaaa gggcacaatg gcgtatcact gctggcgaag ttttttcggg tccagccatt 630961 acagtcttct tttgtgcatt cccaagtact cacatcttcc tttggcagcg gttcttgatt 631021 tcgtttgtta tagtaagaca taaagtcact tcttccctca tgtattttac tgcacatttc 631081 ctattgtctc atacttttcc ctaatctcct aattcctttt tctttatgac tttccaataa 631141 ccccatctaa aaaggagagg agtgtgctgt taaaagcatc tggctcttct aaaaacgggc 631201 aatggctgct tttaggaaag gtaacgagtg tcgcgtttgg aatattgctg cgcaagtgtt 631261 ccccagctgc tgtagagaaa aatttcttgt cttccccgaa gcacagcaat gccggcacat 631321 tgatgttttg gagggtgccc cggtaatcag cggccgtttg gttaaataaa atcgtgctag 631381 aaatggcagc cggctgtttg aggatttctg ccagcatcca ttctgtttcg gtctcggcag 631441 gcggttctgc gaacatattc tggatgaagc tttcgtagaa aggcagcggg tcagtttgaa 631501 tggcgtgcat cgctgttttt aagccgtcaa aatcaaatgg accatgttcc cagccctccc 631561 attgatagtc cgaagcggat tgatcgatga tcacagcggc ttgaatgtta tcattcccaa 631621 actgattgag ataatcccat acgacaaaag cacccattga ccagccggca agaacgacat 631681 gatcaagctc cattgcattt agaaattccc ttatgtcacg ggcatattgg gaaatggtgt 631741 ggccgtgaag cactttgtca gattcgccgt gtcctctaag atcaagacga atacattgat 631801 aattggcaga aagcaccgaa aattgtttgt ggaaaaattg tccgctcatc agcaccccat 631861 gtataaacag gatcggcgtc ccgctcccgt gtgtttcata gtaaaggcgt gtctgatctt 631921 ctaatatgat gtatggcatg tttctcctcc tttagtttcc atcatgagta tggctggctg 631981 ctgttgagct gatgatggca gctgtcgcgg ctgcctgctg cgcttgaatg actgtttcga 632041 tagcggtgta tagtcctgat tccatcagca gatttttctc catatgctca ctgagataga 632101 ggctgacagc aattttaaag ttcatttcct tttgccattt aaaagctttt tcctggttta 632161 attcgtcagt gatgcacaaa acggttttga tatctggctc ttccagaaat gtgaggagag 632221 caaggtctgg ataatgataa tcctttgttt ttttgacaga ttcagtgatc gattgatata 632281 tctgtttgca agcggaaaca agcatttcgg gctctttttc actttgcaag gccagaatat 632341 ggctgacctg atgtaagtac tgtccttttt taaagccgtt ggctgccagc agttgatagc 632401 atgtttccgc cttctgtagc gcctgcaaac cttttccgtt ttctccaagc agtacggcaa 632461 gcggaacatt ctgagttgaa gtgaggaaat aatgattttt cttcatctgc tgataaacag 632521 ctagccccat gttcatctgt tctttttggt ttgtcgtttc agatttgccg gtgagcaaga 632581 tcagagcgga aaggtatgtg aacatatccc gcttataccc tagcttcacc atttcattgt 632641 atacatcgat gaaagtctga aatgtttgtt ttgcctcatg ctgaaaatga atgtccagaa 632701 tagatgcaac agtaaagcgg tggtgtgaat tgagtgttga gaagctgccg atgtttgatt 632761 tgatatagct gctcaaatca taaaagcgct gaaaatcaaa ctctctttta ttcacaatat 632821 atgcagaaga aatgagcatt aatatctgat cgtgtgaaac tttccatttt aattttgttt 632881 ttaattcagc ataaatggaa atgtaatgct ttgttttttc atgtagatcg tgtgtgagca 632941 taaaaagcag ctccttttgt tgtttttacg taatacgata aatagggcca aaggtttcat 633001 aaagaaaaaa cttgcctgct agaggcaagt ttgtcgggtt atttatgggg atcagttata 633061 tccatcggtc tcatcatgtc atagtcttca tgctctagaa tatggcaatg ccatacgtat 633121 cgtccgctgt acggaccgaa tgtcgccgcg attctcagga cttcacctgc atgcgcttga 633181 atggtgtctt tccagccctt ttcacttggc ggcggcggga cagccggacc ggtataggac 633241 aattccccgc tttcttgata acgggcgata tcaaacggcc gccggtctaa tacacggaag 633301 gagactagat gcaggtggat cggatgtgtt ccgcgtgtcg ggttgataat ggaccatatt 633361 tcagttgtgc cgacttttgg tgtttctgtg acgggatcgt gccagcgttt gttattaagc 633421 agaaggacgg gtctgccgta ttcgtcctgg gtgcctgcca gttttaacgt tctgatgttt 633481 tgtattcttt catgctgtac cgaagggtat gaggcgaggt acttcggctt tctgctttcg 633541 tctttttgtg ccaatggttt tgtgactctg aattgcatga tattcgcatc tgtttcagga 633601 ttgacgtcac cgccgcagcc cgcgctgttt gccaaaatga tcgattctcc ttcatatgct 633661 gtgaagtcaa tgatgatatc gtaacgttca gcaggcgcaa ggctgaaaga attcagttta 633721 acagatcgcg gcaggagccc tccatctgaa ccaatctgaa taaaatctcc gccattatcg 633781 agtgacaggt tataggttct tgtattggag gcgttgatga cacggaatcg gtatttcctt 633841 ggctcgactt ccaagtatgg ccataccttc ccgttgacga gtatggtttc tccgcaaaaa 633901 gccggaacga ttgaaggatt aggcagtgac ggagaagggt tttccggtgc gctcggataa 633961 aacaaagaac catcctcatt gatcgtgcgg tctgtgataa gaagcggcac atcgtattcg 634021 tctgaaggca gttttaagcg tttttccttt gggtcatgaa tgatatatgc accgacaagt 634081 ccggcataga catttagcct ggtgagcgcc atggcgtgat cgtgatacca caatatagcc 634141 ccgcgctgct ggtttggata atgataaacc tctcttttga aataaggtcc tgtttgttca 634201 aagtctttgg aaaaccaagc ctccggatac ccgtcactat catctggcgt gacgccgccg 634261 tgtaaatgaa caacagtctt tacctcgggc tcttcatgct ggctgtcact gtgatgaatg 634321 gtgtgatcaa tcggaaggaa atgcgtggaa ggaaggttat tcatccattt tacatatacg 634381 ttttcatttc ttttaacctc aatggtcggt cccggaaata agccgttgta gccccacagg 634441 cgggttggag ggagatcgcg atggagctga tgagtgcatt cctccatggt gacttcgtag 634501 tatgtttttt cttttgattg ctgtactggc tttagtgtat ctgggattgg gagagcatcc 634561 acaaattttt caagtgtcat tttcatctgt ccttatctaa attttccaaa ttggtactat 634621 agttaatgac aataaggacg tgatggttac aaaaaatctt cgtgctgcag cccgcccgaa 634681 gaagaaaata acaaaatcct aaacggcagg ccgtttagga tttgatcagc attaaggcag 634741 gatatcgggt tgctgctgtg tgactgggtt ggcagccgct ttctcgctca ccttgcgttt 634801 tctgaacaca aggtaagaaa tcagaacgat tcccgtgatg acgcctgtca gcagcagctc 634861 gtctctcatg gaatcaataa acgccatgga cactaaaatt ccgcaaatgg cgatgatggt 634921 caagtaggtt aggaaaggga agagccacat tttgatcttc aatgcttctg ggtttgtttt 634981 ttcgagtttt ttccgcattt tcagctggga aacggcgatg acaagataga cgagtaaagc 635041 gattgcgcct gatgagttga ctaagaataa aaagacggta tccggtgaaa aatagttcat 635101 tacgaccgcg atataagaga aaaatgtccc ggccacaatg gcttgtacgg gaacgccttt 635161 tttgctcaat ttcataaaac ggcgcggcgc ttcatttctt tctgcaagtg aatacagcat 635221 tctggatgtg gtatacaaac ctgaattcag gcaagagagt acggctgtga ggacgataaa 635281 gttcataatc tgtgcggctg cgggcactcc tatatgctca agtacagcga cgaaagggct 635341 ttctaaaata tttgctgaat tccatggcaa cagcgccacg acaatggcga ttgagcccac 635401 gtaaaagacg atgatgcgcc atacaacgga tctggtggct tttgtcacag attcgatcgg 635461 gttggatgtt tcccctgctg caatggcaac gatttcagtt cccataaaag agaagatgac 635521 aacgacaatg ccgagcaata cggagctgat gccctccggg aaaaatccgc ctttgcctgt 635581 aagattcgaa aaaccgactg gctcactgcc cggtgcaaag ccaaaaataa aggcaaaacc 635641 aacgattaga aaagcaatga tagtcacaac tttaatgagg gagaaccaat attcaaactc 635701 accgaaagac ttaacggagt agacgtttgt cagggtgagc acaatggtca agatcaaact 635761 tgtcagccac agcggaatat catggaacca gtattgaata atgccagcac cggcaatggc 635821 ttcgatcgct atgacgatca cccagaaaaa ccagtacagc cagccgattg taaatcctgc 635881 ccacggtccg atggcgtcgt gagcgtattg agaaaacgat ccgctcgtcg ggtttacggc 635941 agacatctca ccgagcattc tcataataaa aatcaccaat aatccggcta acgcgtaaga 636001 aacaacggca cccggaccgg tcgagtgaat cactgaaccg ctgcctacaa ataggccggc 636061 tccgattaca ccggcaatcg aaatcattgt catatggcgg gtctttaatt ccttttttaa 636121 tcctgattga gactggttca taagttacct ccttttaaaa tgcaatcatt actgaatatt 636181 atgataattg aaactctatc ataaatatac agtttgtcga aaattcgtgt aagaaaatat 636241 accagcttat ttcaaatttg tagtgttttg tttgcgcttt cagcgaatgt gtggaaaaaa 636301 tgtttcgttt tttattcgct gtgtgatttt gcgtaatatt tacaattcga tagaatgcga 636361 gaagcactgg tgtccttggg tttgatggga tttttggcgg agcaaataaa ttggatgaga 636421 gaaaaagtgt tccttcgtca ctatttttct gtggcgggtg aatcatgttt ctgtagaccc 636481 actgcggatc agctttgtaa gataataata ggaaaatgtg agcgagagga ggttttgtat 636541 ggagagatat gatgaactga aaaagggaga atccggagcg ctggtcagca ttgccgcgta 636601 tctagttctt tccgcaatta aactgatcat cggttatctt tttcactcgg aagcacttac 636661 ggcagacggg ttaaataaca caactgacat tattgcttct gttgctgtgc tgattggcct 636721 gcgcatctct caaaagcctc ctgacgaaga tcatccatac ggccactttc gagcggaaac 636781 gattgcatcg cttatcgcat cgtttattat gatggttgtc ggactgcaag tgctgttcag 636841 cgccggagaa tctatttttt ctgctaaaca agagacgcca gatatgattg cggcttggac 636901 ggcagcgggc ggggcagtcc tgatgctgat cgtttaccgg tacaataaaa ggctggccaa 636961 aaaggtgaag agccaggcgc tccttgctgc ggctgctgat aataaatcag acgcattcgt 637021 cagtatcggc acatttatcg gcattgtggc tgctcaattc catcttgctt ggattgatac 637081 ggtcactgcg tttgtgatcg gtctgcttat ttgcaagacc gcatgggata tctttaaaga 637141 gtcatctcac tctttgacag atggattcga cataaaggac atttccgctt ataaacagac 637201 aatcgaaaaa atctccggtg tgagccgttt aaaagacata aaagcaagat acttgggcag 637261 tacggttcat gttgatgtgg tggttgaggt atcggcagat ttaaatatta cggaaagcca 637321 cgatatagcc aatgaaattg agcggagaat gaaggaggag catgcgattg attattcgca 637381 tgttcatatg gagcctttag aacaaaaata atggagcttc ctgtcacagg aagcttcagc 637441 gtgtcgacaa accctcgcat tcgttgtcag gtctgcgctt cggtgctcac gaattagaac 637501 attcgctccg ctcctatgct cgtccttcct agacttcaag ggttttcaat cacgctgaaa 637561 agatgacaaa accctaaaat gaaagccatt ttaggatttt gtcaacaatc tggagcttcc 637621 tgccacagga agcttttttg tgtgttttgg ccagctttat tggtaacaat ttgctagaat 637681 cgttttttta tacagattgc tttttgtggt aaagttaggt tacattatga tgaattttgt 637741 agatgactag gaggaaaata atggcatatc aagaagacct gcatcctttg ctggggaaag 637801 cagttgaaca tattaataga gtaatggttg gaaaacgaga catcgccata ctcagcttag 637861 cagcccttct tgccaaaggg catgtgctgc ttgaggatgt acccggagtc ggaaaaacga 637921 tgatggtccg cgcgctggca aagtcaatcg gcgccgattt caaaagaatc caattcactc 637981 cggatttgct gccatctgat gtaacagggg tatctatcta taatgcgaaa acgatggaat 638041 ttgaatatcg tcccggccca attatgggaa atatcgtgct ggcagatgaa atcaaccgta 638101 cctctccgaa gacacagtcg gctttgctcg aagcgatgga agaggggagc gtcacggtag 638161 atggccatac gatgcagctt gccgatccgt tttttgtgat ggcaacgcaa aacccggtcg 638221 aatatgaagg gacctatcct ttgccggaag ctcagcttga ccgtttttta ttcaaacttc 638281 ggatgggtta tccgtccttt aatgaagagc ttgacgtctt atctcttcag gaaaaaagcc 638341 atccgattga gacgcttgag ccggttattg caaaagaaga cttcatcttt ttacagaggg 638401 aagtgcaaaa tgtccgtgct gatgacagca ttaaggaata tatcgttgaa attgtgcaga 638461 aaacgagaca gcatccttct gttcaattag gcgtcagtcc gcgcggctca atcgccctca 638521 tgaaagcggc acaggcatac gcgctgctgc atcatcgcga ctatgtcata ccggatgata 638581 ttcaatattt agctcctttc acgctgccgc accggatgat gcttcatcct gaggcaaaat 638641 ttgaagggat tcaggcagaa gcgatcgtaa gggagatcat gtcagctgtg aaggtgccgg 638701 ttcaaaggtc ggcggtccgc tgatgaataa gaaatggcaa tggctcgtat atggttggaa 638761 gctgattata ttaactttat tgacggctgc tgttttttct tatgcgatgt ttcagggcgg 638821 ctttgtcagc tggtttttgt tttacgcgtt tctccctttt gtcttgtatg ccgggctgtt 638881 ggccttgtat ccgctccgtt cttttcaggc ttcaaggcaa atggataaaa cacaattgca 638941 tgcgggggac aggctgggcg taacggttac gctgagaaga aagctgccat ttccgctgat 639001 gtatatggtg attgaagatt gcctgccaga aggtatcgag tcattaaatc gagacggagc 639061 cgcggccaaa cggctcgttt ttccttggtt taaacggagc atgacgatgt cgtatgaatt 639121 agctcgggta ccgcgcggag agcatcactt tcattctgtc agggtgcgaa ccggggatgt 639181 tcttggcttg attgaaaaaa cagcattttt tgagctggat gataccttgt ttgtttatcc 639241 attctatcag cgtttttcct atcaggtgaa tgagaggcat caggaagacg gtgtaagcgg 639301 ttcttctcct attcatcagc accattcctc agtcgcagca agtgtgcgga attatcagcc 639361 gggagaccgg tttgctgcgt tagattggaa gacatctgca cggcggagcc agctgatgac 639421 gaaggaattt gagccttctc gcagcaaaaa tctgtttctg ctgatggacc gtttttcctc 639481 agacgcattc gaagaggtcg tttcagtgac agcttcgatt cttcattctg ttttaaaaaa 639541 cggcgcgggt gctggtctgg cttccatcgg gaaggaaaaa aacattttcc ctattcagga 639601 aggggatcag cattttaagc acatgcttcg gcatttagcc atcgctcatt gtgatgcggc 639661 agacccgata agccgatatg cacgggaaga gctgggaaag ccatctgttc gccaagctga 639721 tcaagttgtt gtcacgggac agttaacgga agatatgctg cacctcgcag aaataggagg 639781 cggccgggtt acggtgatac tggcaaaaga gaaagatgct gagctctctc aagctgaaaa 639841 tgtcatgatt gaacgcatga tgaaacgcca aatcagagtt cggatcatga ggggcgggcg 639901 agtttcgcgt gttgtttaga aagagaggtg actggttcac atgccgcacg atgatcacaa 639961 gggaagccgt ttgagcttgc tgttatttta ttttctggct tttttattgc tgtgggagtg 640021 gcttaggccg cttgacagtt ttactgaaac gaaacataca ggctttttta gtgtctttat 640081 cggcttgacg tttctgctga cttttttcag gatgaggtgg tttgtcaccg ttcctttttg 640141 tgtcatattt acattgatct cgatacacat cctgttttat caaggatcta tattcgactt 640201 gagctgggtc agctcttttt tgcaggatgt ctatctgaat atcacgctga ttcaatcagg 640261 gcaatggaat gacatgattc cttcatttcg gaccctgctg ttttttgtgc tgctgtggct 640321 gctggtctat ctcctgcatt attgggtgat ttaccagaga agaattttgt ttttcttttt 640381 gatgacagta gcgtatatta cgattcttga tacctttacg ccatatgatg ccacttttgc 640441 cgtaatccgt atcgtgctga tcggcttctt tatgctgggc cttttatact tggaacgcat 640501 taagctgatg gaaagaatca cactgccaaa aacatctgtc ctgaaatggt ttcttccttt 640561 atctgtattg gttttggctg caacgggatt cggactcgcc gctccaaaat cagagccggc 640621 ttggcctgat ccggtgcctt ttcttaaaaa aatcactcat caagaccgcg tgtctgcagg 640681 ggaaagcaaa atcggatacg ggaatcatga tgaatcactc ggcggcccgt tccagcagga 640741 tgctacacct gtttttacat ggcagggaaa agagcgtacg tatttccgtg tggaaacgaa 640801 ggacacgtat accggaaaag gctggattga aacagacaca ggcatgtcgt atcagcttag 640861 caatggaaaa gttgaaaatc tgtggtttga ccataaggtt gcgacagagc gccgcaccgt 640921 ccgtgtaaaa gtcgataagc actacgggta taaccatctg atgtatccga ttggtgcgga 640981 aaccattcag ccaaagcagg ctgtctcact tgaaatgaac ggcaacacgg agcaaatttc 641041 tccgatcagt gaacaagccg gtgaaatcag aaatatgggg aattatacag taacgtacaa 641101 ttccccggtc tataagctgg atgaactgag aaaggtaaaa gtgagaaaaa acagtgagga 641161 gtacacattc agcgatcgct acatgcagct tccagattca ctgccagagc gggtgagaac 641221 ccttgcgatc aaactgactc aggatcacga caatatgttt gataaggtga aagcggttga 641281 ggactattta gggtcaaatg cgttcacata tgaaacagaa aacgtgacca ttccgaagaa 641341 tgatgaagat tatgtcgatc aatttctctt tgaaacgaaa atgggttatt gtgataactt 641401 ttcttccgcc atggtggtgc tcttgcgctc ggccggcatt ccggcccgct gggtaaaggg 641461 ttatacgtcc ggcgaataca aagaagcagg gaacaaaaat ggcagcattt acgaagtgac 641521 aaataacaat gcccattcct gggtagaggt gtatttcccg gaacagggct gggttacatt 641581 tgagccgact aaagggttta caaatccggc tcaatttaca tcttctgaca caaaagactc 641641 tggcagcgat agcagcagct cgccgaagaa agcaaaagag aaacagaaag aagagaaaaa 641701 acagccgcaa aaagaggaaa aacaaaagga aaagcgggag ccagctgttt ctaaaaagcc 641761 gtccgcttcg catactaatg ccggtgcggg cttgtatgca gcgcttgcgg ttcttgcagt 641821 cctcctggtg gcagctgtat tgctgtatgt tttccgctcg ttatggattc ctgttttcgc 641881 cgtgaggaaa ttgaagcggc gcagtgatca gcacgcgttt tttgaggcat atggcgcgct 641941 gctgaaacaa ctgaagagaa aaggactgcc gaaacgagac agtgaaacgc tgcgtgatta 642001 tgcaaaacga attgatgaaa aatacgacat agaagacatg tcaaagctga cattaagcta 642061 tgaaagggcg ctttacagaa atgaagattc ttcggcgcta tggaatgatt cgagagagtt 642121 atgggaaaat ttaattaaaa gaagatggtc ttgaccgctt atcgacgtgt tgttagaatt 642181 agtgaatatt atcggagtct gggagcgagt tggcctgact ccggcaaacg gccttgccaa 642241 agagggcgga gcgagcttca tatctgtcct cgtttttttc tgtgtcaaaa aacttagagg 642301 agattaggtg acaaccatga caaagttagt gaatgaaatg attcttgtcc ttgatttcgg 642361 cagtcagtat aaccagctga ttacacgccg tatccgtgaa ttcggtgttt acagcgagct 642421 gcatccacat acattgacgg ctgaagaaat taaaaaaatg aatccaaaag gaattatttt 642481 atccggcggt ccaaacagtg tgtatgatga aaactctttc cgctgtgacg agaaaatctt 642541 cgagcttgat attcctgttt tgggaatttg ctacggcatg cagctgatga ctcattacct 642601 tggcggtaaa gttgaagcgg caagccagcg tgaatacgga aaagcaaaca tccgcatcga 642661 aggcacacct gatttgttca gagatcttcc gaatgaacaa gtggtttgga tgagccacgg 642721 cgatttggtt gtagaagttc ctgaaggctt cactgttgac gcgacaagcc atcactgccc 642781 gaactcagca atgagcaaag cggacaaaaa atggtatggc gttcagttcc acccggaagt 642841 gcgccactct gaatacggca atgatcttct gaaaaacttt gtattcggtg tttgcgaatg 642901 cgaaggcgaa tggtcaatgg agaactttat cgaaatcgaa atgcaaaaaa tccgtgaaac 642961 ggtcggagac aaacaggttc tttgcgcgct aagcggcggc gttgattcct ctgttgttgc 643021 tgttttgatt cataaagcga tcggcgacca gctgacttgt atctttgtag accatggtct 643081 tctccgtaaa ggcgaagctg agggtgttat gaaaacattc agcgaaggct ttaacatgaa 643141 tgtgattaaa gtagacgcaa aagatcgatt cttaaacaaa ctaaaaggcg tttctgatcc 643201 tgagcaaaaa cgcaaaatca tcggtaatga attcatttac gtgtttgatg atgaagcgga 643261 caagctcaaa ggcatcgact accttgcaca aggtacgctt tacacagata tcatcgagag 643321 cggtacagca acggcgcaaa cgatcaaatc tcaccacaat gtcggcggac ttcctgaaga 643381 catgcagttt gagctgatcg agccgttaaa tacgctcttc aaagacgaag tgcgcgcgct 643441 tggcacagag ctcggcattc cggatgaaat cgtatggcgt cagccgttcc caggaccggg 643501 actcggaatc cgcgttcttg gcgaagtaac agaagaaaaa cttgaaatcg ttcgtgaatc 643561 agatgcaatc ttgcgtgaag aaattgcaaa tcacggctta gagcgtgata tctggcaata 643621 cttcactgtt cttcctgaca tccgcagcgt tggtgttatg ggtgacgcaa gaacatatga 643681 ttacacaatc ggaatccgcg ccgttacatc aatcgacggc atgacatctg actgggcgcg 643741 tatcccgtgg gatgtgcttg aagtcatttc gacacgtatc gtaaacgaag tgaagcacat 643801 taaccgcgtg gtgtatgata ttacaagtaa gccgcctgcg acgattgagt gggaataaga 643861 atcaattaat ggaaaccatc tttttggcaa ttttgccggg aagatggttt tatttgttta 643921 ttacgaacaa aatccgattt tgcgcgacta ttgttcgctt tttgtattgt tttttcaaaa 643981 tgaacttggt acaatagaca cagaaatcaa ataagatgaa ttcgtataat cgcgggaata 644041 tggctcgcaa gtctctacca agctaccgta aatggcttga ctacgtaaac atttctttcg 644101 tttgatataa ataaaacacg gttatttatt caaactgaaa tccgtctgta gtcaagcgtc 644161 ccaaaatgta ttgggacgtt ttttatttgg cgttttcagg acagaataaa tagcaaagag 644221 tgaagggagt caaatagctt gaaaacgttt tttcagtttg atgagctggg caccagctat 644281 cgcaatgaaa tcattggcgg attaacgact tttttatcta tggcatatat tttgttcgtc 644341 aatccgatta cgcttgcttt ggagagcgtg aaagattttc cggaggcgct gagaattgac 644401 cagggtgcgg tctttacggc gacagcgctg gcgtctgcag caggctgtat cttaatggga 644461 ttaatagcga gatatccgat tgccatcgcg ccgggtatgg ggctgaacgc gttttttgcg 644521 ttttctgttg tccttggtat gggtatttca tggcaggcag ctttgtccgg tgtttttatt 644581 tcaggtctta ttttcgttgc tctttcttta acaggttttc gtgaaaaaat catcaacgcc 644641 attccgcctg agctgaaatt ggcagtcggt gcggggatcg gcctgtttat tacatttgtt 644701 ggattacaag gttcaggaat cattacagcg aatccttcta cgctcgtcac gatcggaaac 644761 attcacagcg gtcctgtgct gttaacgatt ttcggtgtga ttgtcacggt tattttaatg 644821 gtgcttcgcg tgaacgcagg cgtgtttatc gggatgctat taacagcggt agccggcatg 644881 attttcggtt tggttccggt tccgactcaa attatcggca gtgtgccaag ccttgcgccg 644941 actttcggac aagcgtggat tcacctcccg gatattttct ctgtacaaat gctgatcgtt 645001 attttaacat tcttgtttgt cggatttttt gatacagctg gtacacttgt tgctgtggca 645061 acacaagctg gtttaatgaa ggaaaacaaa ttgccgcgtg cgggccgtgc gcttttagct 645121 gattcatctt ctattgtgat cggtgccgtg cttggtacgt ctacaacaac ttcttacgtg 645181 gaatcaagct caggtgtcgc tgcgggtgcc cggtcaggat ttgccgcaat tgtaacaggg 645241 attctctttt tactggctac gtttttctcg ccgctcctat cagtcgttac gtcaaatgta 645301 acagcgccgg cgcttattat tgttggtgca ttgatggtgg cgccgcttgg caaaatcgct 645361 tgggataagt tcgaagtggc cgttcctgct ttccttacca tgatcatgat gccgttaacg 645421 tacagcatcg cgactggtat tgccatcgga tttattttct atccgattac aatggtgtgc 645481 aaaggaaaag caaaagaggt tcatccaatc atgtacgggc tgtttgtcgt atttatcctg 645541 tactttatct tcttaaaata aggaatgaaa aaccagctgc actggcagct ggtttttttg 645601 ttgcaaaaga taaaaccatt tcatacgata taccgtcatg tagatgtgcc gccatgcttt 645661 acttaaatgg aaatgacttg actgttcagg aaggcttcgg taccttatat aagtgtttta 645721 ttttcttgct gaatggtatt ccgccgtatt tttttgatag gagttgctga catgacggaa 645781 gaaagaaaag aaacgtttga agaagaaatt aaccagagtg aaagaataga tgcagatgaa 645841 gaaccgctat cgagaatgtc cagaaaggcg agccggcaaa gcaagcagaa gcaaaaacaa 645901 aagcagaaac cgcgccagga acgcggtgaa tcaactgtta aagacaagct tgcgtctgtt 645961 tgggcagcca tcaacagata ttgcggtttt gcgttctcga ttttaaaatc tccggcgaaa 646021 actgtcgtaa cggatggttt ttctcattat aagtacggtc tgatttcaat gcttatattc 646081 agtatcattt tttcaattgg gaattggttt cagttaaagg caagctggaa tcggccgctc 646141 ggtttcggag aacgccatca tgctttctat gacgggtttt tagttgttct tgtgtatttg 646201 ctgatctttt tcgcggtaat ggtctttgct atatgggctg tctcccgcta tatgatgaag 646261 cagaaggtga cgttcagaga agcggctgcc gtattgggtt cattgcttgt acccgtaatt 646321 gctgtttcaa tcctttggct gatctttgcg atcgtaaata tcccaatgct gacagtactg 646381 tttacggtgc tgatcttgtt ttccatcttt tttatcatcg cgctgtatgt acagcgtgtg 646441 taccaggcgg cacaagatgc accaattgat tatatctatt gtgtatttgc agtagttgcg 646501 atagcgctgc tgtttacggc agtgacttgg ccgtttattt ctgaatatat tacggcgtcg 646561 ttgattccgc tttaatgaaa aaaccggcta atcctagccg gtttttttat gtcacacttt 646621 ttacaaatat atctaaaaaa catagttgat ttgtaggatt aacccgtgta tgatggggaa 646681 aatgctgaaa acgtccagcg caaaaacctt tatgtttaag gaggatgatg gacatggctg 646741 atgtacttcg ccgagcaatt aaccaaaaga agcaattttt aaaaaccaaa ttactgctct 646801 cggaatttta tcaaggaaga ggggaacagc ttgctgacta cacgctgagt gagcttgaga 646861 aagaatacaa gtcccttcag aaaatgaaaa aagagatctg acaatagata taaagaggtg 646921 agtctgctga aaagcgggct tttttgtttt gattttgaaa aggcgagaaa gagggtaaac 646981 tactactgtt caacacataa aagcgtgtcg aaatattttg cttaagctta cgggcgaagc 647041 tgattgtaaa cggctcattt ctctagtaga atatgaatgc tttgtgcaag ctgaagagta 647101 gggggatgaa taaaatgatg caaaccatct tatcaaatgg gatagccatg gttctcataa 647161 ttctcattat taatattgtc tatgtgtcat tttttacgat aagaatgatt ttaacgctga 647221 aaggacagcg ttatttagcg gccggcatca gtacgattga aatactggtt tatgtgacag 647281 gactgagtct ggtgctcgat aacttagacc agattcaaaa tgtgatcgcg tacgcgctcg 647341 gttacggtct tggcgtaatt gtcggcatga aaatagaaga aaaattggcg cttggctata 647401 ttatggtcaa tgtgattacg aaggagctcg atcttgatct tccgaagcag ctccgtgaaa 647461 aaggctacgg cgtgacaaac tgggtggcag gcgggcttga aggcgaccgc acagcccttc 647521 agatcctgac gccgagaaga tatgaactcc agctatatga tacgattaaa acacttgatt 647581 caaaagcctt tattattgcg tacgaaccaa aaacaatcca cggcggcttc tgggtcaaag 647641 cggtgaagaa gaggagaatt aaagaataat ggcaaagccg aagaagaaaa agtttgaagt 647701 gacagagcag caaacgattg atgcggtgct tcagcaaatg aaagaagaag gatatctgcc 647761 tgtaaggcga atggaagagc ctatttttat ggaaaaaaag gaaaatgggt caattcagat 647821 cgttccgtgc gggaaaaaaa tcgtatttga agggaaattg atctaaaaca cgaacattag 647881 tagaatgaat ttttgtatcg ttcgataata tcgttgacat tatccatgtc cgttgttaag 647941 ataaacatga aatcaaaaca cgacctcata taatcttggg aatatggccc ataagtttct 648001 acccggcaac cgtaaattgc cggactatgc aggaaagtga tcgataaaac tgacatggat 648061 atatcgcaga agcgaacgac tgacgataca tgtaccatgc ccggtttgta ttgcttcctc 648121 ataagtgcaa tgcagagcgg gtatttttta ttttctgaaa acaaaagcat tagaaggtgg 648181 ggaacagaat gcagccgcta gtaggaatca tcatgggaag cacttccgat tgggagacaa 648241 tgaaacacgc atgcgacata cttgacgaac tcaatgttcc gtacgaaaaa aaggtcgttt 648301 ccgctcaccg gacgcctgat ttcatgtttg aatatgctga aactgctaga gaaagaggca 648361 tcaaggtgat tattgccggt gccggaggag cggcgcatct gccagggatg acggctgcga 648421 aaacaacact gccagtcatt ggagttccgg ttcagtccaa ggcgctgaac ggaatggatt 648481 cacttctttc catcgtccaa atgcctggag gcgtgcctgt tgcgacaaca tccatcggca 648541 aagcgggtgc tgtgaacgca ggcctgttag cggcgcaaat tttgtcagca tttgacgaag 648601 accttgcccg taagctggat gagagaagag aaaatacaaa acagacagtg ttagaaagca 648661 gtgatcagct tgtctaaaca aatcatctat ccgggagctg taatcggcat tatcggcggc 648721 ggccagcttg ggaaaatgat ggctgtgtcc gccaaacaaa tggggtataa agtcgcggtc 648781 gttgatccgg tgaaagattc gccgtgcggg caggttgcgg atgtcgaaat taccgctcat 648841 tataatgacc gtgaagcgat tcgaaaattg gctgaaatca gcgatatcat cacatatgag 648901 tttgaaaaca tcgactatga tgcgctgcat tggctaaaag atcatgcgta tctcccgcaa 648961 ggaagtgagc tgctgcttat tacccaaaac cgtgaaacag agaaaaaagc aattcaatcc 649021 gcgggctgtg aagtcgcacc gtacagcatc gtcaaaacaa agaatgaatt gaaacaggca 649081 gtacaggagc tcaggcttcc ggcagtgctg aaaacatgcc gcggcgggta cgacggcaaa 649141 ggccaatttg tgataaaaga agaggcgcaa atggagcagg cagccgctct gttagaacac 649201 ggaacttgca ttcttgaaag ctgggtttct tttaaaatgg aactgtcggt gatcgtcgtt 649261 agatcggtaa acggtgaaat ttcaacattt ccgacagctg aaaacattca ccacaacaat 649321 attcttttcc aaagcatcgt gcccgcacgg gtagagaaag ggattcagca gaaggctgct 649381 gatctcgcag ttaagcttgc agatgagctt aaccttgtcg gaccgcttgc tgttgagatg 649441 ttcctgacag aggacggaga gcttttggtc aatgaactgg cgccaagacc gcacaattca 649501 gggcattata cgctggacct ttgcgagacg agccagtttg agcagcatat cagagcggta 649561 tgcgggcttc cgcttgggaa gacagatttg ctgaagccgg gcatgatggt gaatcttctc 649621 ggcgatgaag tgaagcttgt tgaggaagac ccggagcttt taaaagaggc aaagctatat 649681 atatacggaa aacatgaaat caaaaaaggc cgcaaaatgg ggcatattac atttatgaag 649741 cagcctgaag acgaatggat tcaggagatc acaaataaat ggatgaatag agacggagga 649801 caagcagaat gatcgaacgt tattcaagac ctgaaatgtc cgcgatttgg acggatgaaa 649861 acagatttca agcatggtta gaggttgaaa ttcttgcctg tgaagcgtgg gcggagcttg 649921 gcgtcattcc gaaagaagat gtaaaggtta tgcgcgaaaa cgcgtcattt gacatcaacc 649981 gcattttaga aatcgaaaag gacacgcgcc atgacgttgt cgcttttacg cgcgctgtat 650041 ccgaatcact gggcgaagaa agaaaatggg tgcattacgg cttaacgtca actgacgttg 650101 ttgatacggc tctttcctac ttattaaaac aggcaaacga tattttgctc aaggatcttg 650161 agagatttgt tgacattata aaagaaaaag cgaaagaaca taaatacaca gtcatgatgg 650221 ggcgcacaca cggcgtacac gctgagccta caacattcgg cttaaaactt gcgctttggc 650281 atgaagaaat gaaacgtaat cttgagcgct tcaaacaagc gaaagcaggc atcgaggttg 650341 gaaagatttc cggtgctgtc ggcacatatg cgaacattga tccatttgtt gaacaatatg 650401 tctgtgagaa gctcggattg aaagcagcac cgatttccac tcaaaccctt cagcgtgacc 650461 gccatgctga ctatatggca acacttgctt tgatcgcgac aagcatcgag aaattcgctg 650521 tggaaatccg cggactgcaa aagagtgaaa cacgtgaagt agaggaattt ttcgcgaaag 650581 ggcaaaaggg ttcatctgca atgccgcata aacgaaatcc gattggctct gaaaacatga 650641 caggcatggc gcgcgtgatc cgcggctaca tgatgacagc ttacgaaaat gttccattat 650701 ggcatgagcg cgatatttct cattcttcag cagaacgaat tattcttccg gatgcgacaa 650761 ttgcgctgaa ctacatgctg aaccgcttct ccaacatcgt gaagaactta acggtcttcc 650821 cggaaaacat gaagcgcaac atggaccgca ctctcggcct tatctattct cagcgtgtgc 650881 tccttgcttt gattgacaca ggcctgactc gtgaagaagc ctatgataca gttcagccga 650941 aagcaatgga agcgtgggaa aaacaagtgc cgttccgcga gcttgtggaa gcggaagaga 651001 aaatcacgtc acgtctttct ccagaaaaaa ttgctgactg ctttgattac aattaccatc 651061 tgaaaaatgt tgatctgatc tttgaacgtt taggtttagc atagaagaag cttttagcgg 651121 cttcttctaa gccgccgcag tttgaaaatt cccaacattc gggttaggag gccttccgtg 651181 aatattgtga agaatgaact tttatacgaa ggaaaagcaa aaaagatcta caaaaccgat 651241 gacgaaaaca cgctgtatgt cgtgtataaa gactccgcca ctgcctttaa cggcgagaaa 651301 aaagcagaaa tcagcggaaa agggcgctta aataatgaaa tttcaagcct cattttcaaa 651361 caccttcatg ctaagggcat taacaatcat tttatcgagc gcatttcgga aacggagcag 651421 ctcattaaaa aggtaacgat tgtgccgctt gaagtcgtgg taagaaatgt tgtggcagga 651481 agcatgtcca aacgtctcgg cattccagaa ggcacggagc ttgagcagcc gattatcgag 651541 ttttactaca aggatgacgc gctgggtgat ccgctcatca cagaagatca tatttggctt 651601 ttgaaggcgg cgactcctga gcaggtagaa accattaagt ccattacaac aatagtaaat 651661 gaagagcttc aaagcatctt cgacgattgt catgtcagat taatagattt caagcttgaa 651721 ttcggtttag atgcagaagg gcaagtgctt ttggcggatg aaatatctcc tgacacatgc 651781 cgcttgtggg ataaagaaac gaacgaaaag ctggacaaag atttattcag acgcaatctg 651841 ggaagcttaa ccgacgcata cgaagagatt ttcaatagac tgggaggcat tcatcatgta 651901 taaagtaaaa gtttatgtca gcttaaaaga aagtgtacta gatccacaag ggagcgctgt 651961 ccagcatgcc ttgcacagta tgacttacaa cgaagttcaa gatgtgcgca tcgggaaata 652021 catggagctt accattgaaa aatctgaccg tgatcttgac gtgctagtga aagaaatgtg 652081 cgaaaaactt cttgcgaaca cagtgattga agattataga tatgaggttg aggaggtagt 652141 cgcacagtga aatttgcggt gattgtgtta cccggctcca actgtgatat cgatatgtat 652201 catgctgtaa aggatgagct cggccatgaa gtggaatacg tctggcatga ggaaacaagc 652261 cttgacggct tcgacggcgt gttaattccg ggaggatttt cttacggcga ttacttaaga 652321 tgcggcgcca tcgcccgatt tgcgaatatt atgccagctg tcaaacaagc agcggctgaa 652381 ggaaaacctg ttcttggcgt ctgtaacgga ttccagattt tacaggagct tgggctgctg 652441 ccaggcgcaa tgagacgcaa caaagatctg aagttcattt gccgtccggt tgaattgatt 652501 gttcagaacg acgaaacctt attcacagct tcctacgaaa agggagaatc gattacaatc 652561 ccggttgccc atggtgaagg gaatttctac tgtgatgacg agacgcttgc tacattaaag 652621 gaaaacaatc aaattgcttt cacatacggc tctaatatta atggaagtgt cagcgacatt 652681 gccggtgtcg tgaatgagaa aggcaatgta ttaggcatga tgcctcaccc tgagcgcgcg 652741 gtcgatgaac tgcttggaag cgccgacggt cttaaattgt tccagtctat cgtgaaaaat 652801 tggagggaaa ctcatgtcac tactgcttga accaagtaaa gaacaaataa aagaagagaa 652861 actgtatcag caaatgggtg tcagtgatga tgagtttgca ttgatagaat ccattcttgg 652921 aagattgccg aactacacag aaatcggaat tttttctgtc atgtggtctg agcattgcag 652981 ctataaaaac tcaaagccga ttctgcgtaa attcccgaca agcggcgagc gtgtgctgca 653041 ggggccgggg gaaggcgccg gaatcgttga tatcggtgat aaccaagcgg ttgtgttcaa 653101 aattgaatca cataaccacc catcagctct cgagccttac caaggcgctg cgactggcgt 653161 aggcggaatt atccgtgatg tattctcaat gggtgcacgc ccaatcgctg tattgaactc 653221 tcttcgattt ggtgaactga cttcaccccg cgtgaagtac ttgtttgaag aagtagtagc 653281 gggtatcgcc ggatacggca actgtatcgg catcccgaca gtcggcggag aagtgcagtt 653341 tgacagcagc tatgaaggaa atccgctcgt caacgcaatg tgcgtcggtt taatcaacca 653401 tgaagacatc aaaaaaggcc aggcaaaggg tgtcggcaac acagtaatgt acgtaggagc 653461 gaaaacaggg cgtgacggca tccacggcgc tacgtttgct tctgaagaaa tgtcagactc 653521 gtctgaagaa aagcgttctg ctgtccaagt cggcgatccg tttatggaga agcttttgct 653581 tgaagcatgt ctggaagtca tccaatgcga cgccttagtc ggcattcagg atatgggagc 653641 tgccggttta acaagctcaa gtgcagaaat ggcaagtaaa gccggttctg gcattgaaat 653701 gaatcttgac ctgattcctc agcgcgaaac aggcatgacc gcgtatgaaa tgatgctttc 653761 tgaatcacaa gaacggatgc ttttggttat tgagcgcgga cgtgagcagg aaatcatcga 653821 tatttttgac aagtatgatc ttgaagcggt ttctgtcgga catgtgacag atgataaaat 653881 gcttcgcctg acacataaag gagaggttgt gtgcgagctg cctgttgatg ccttggcaga 653941 agaagcaccg gtttaccata agccttctca agagcctgct tactatcgcg agtttttgga 654001 aacagacgtt ccggctccgc aaattgaaga tgcgaatgaa atgctgaagg cccttcttca 654061 gcagccgacg attgcgagta aagagtgggt ttatgatcag tatgactaca tggtgcgcac 654121 gaatacagtt gtcgctcctg ggtctgatgc tggtgttctc agaatccgcg gaacgaaaaa 654181 ggcgctggcg atgacgacag actgtaacgc gcgttatctc tatcttgatc ctgaagtcgg 654241 agggaaaatt gctgtcgctg aagcagcgcg caacatcatt tgctcaggcg cagaaccgct 654301 tgcggtgaca gataacctta acttcggaaa ccctgagaag ccggaaatct tctggcagat 654361 cgaaaaagcg gcagacggca taagcgaagc gtgcaatgtt ctcagcactc cggttatcgg 654421 cggtaacgta tcgctttata acgaatcaaa cggcacggcg atctatccga caccagttat 654481 cggcatggtc ggcctaattg aagatacagc gcacattaca acacagcatt tcaaacaagc 654541 aggagatctc gtatacgtga tcggcgaaac aaaaccagag tttgccggaa gcgagctgca 654601 aaaaatgaca gaaggccgta tttacggcaa agcgccgcaa atcgatcttg atgtagagct 654661 gtctcgtcaa aaagcactgc ttgacgcgat taaaaaaggc ttcgttcaat ctgcgcatga 654721 tgtgtctgaa ggcggcttag gcgtagcgat tgcggaaagt gtcatgacga cggaaaacct 654781 tggcgctaat gtgactgtag aaggggaagc ggcgttatta ttctctgaat ctcaatctcg 654841 cttcgtcgtt tcagtgaaaa aagaacatca agctgcgttt gaagcaactg tcaaagatgc 654901 agttcatatt ggtgaggtaa cagctgacgg aattctggcg attcaaaacc aagacggaca 654961 acaaatgatt catgcgcaaa cgaaagagct tgaacgcgta tggaaaggag ctatcccatg 655021 cttgctgaaa tcaaaggctt aaatgaagaa tgcggcgttt ttgggatttg gggacatgaa 655081 gaagccccgc aaatcacgta ttacggtctc cacagccttc agcaccgagg acaggagggt 655141 gctggcatcg tagcgactga cggtgaaaag ctgacggctc acaaaggcca aggtctgatc 655201 actgaagtat ttcaaaacgg cgaactcagc aaagtaaagg gaaaaggcgc tatcgggcac 655261 gttcggtacg caacggctgg aggcggcgga tacgaaaatg ttcagccgct cctcttccgt 655321 tcccaaaaca acggcagcct ggcgcttgct cataacggaa atcttgtcaa cgccactcag 655381 ctgaagcagc agctcgaaaa tcaagggagc atctttcaaa cctcttcgga tacagaggtt 655441 ttggctcacc tgatcaaaag aagcggacac ttcacgctga aggatcaaat taaaaactcg 655501 ctttctatgc tgaaaggcgc ctacgcgttc ctgatcatga ccgaaacaga aatgattgtc 655561 gcacttgatc caaacgggct gagaccgcta tccatcggca tgatgggcga cgcttatgtg 655621 gtcgcatcag aaacatgcgc atttgacgtc gtcggcgcaa cgtaccttcg cgaggtagag 655681 ccgggagaaa tgctgatcat taatgatgaa ggcatgaaat cagagcgttt ttccatgaat 655741 atcaatcgtt ccatttgcag catggagtac atttatttct ccagaccaga cagcaatatt 655801 gacggtatta atgtgcacag tgcccgtaaa aaccttggga aaatgctggc tcaggaatcc 655861 gcagttgaag ctgacgtcgt aaccggggtt ccggattcca gtatttcagc ggcgatcggc 655921 tatgcagagg caacaggcat tccgtatgag cttggcttaa tcaaaaaccg ttatgttggc 655981 agaacgttta ttcagccgtc ccaggctctg cgtgagcaag gcgtcagaat gaagctgtct 656041 gcggtgcgcg gggttgtaga aggcaaacgc gtcgtgatgg tggatgactc tatcgtgcga 656101 ggaacaacta gccgccggat tgtcacgatg ctaagagaag cgggtgcgac agaggtgcat 656161 gtgaaaatca gttcaccgcc gatcgctcat ccgtgctttt acggcattga cacttccaca 656221 catgaagaac tgatcgcgtc ttcgcattct gttgaagaaa tccgtcagga aatcggagcc 656281 gataccctct catttttgag tgtggaaggg ctgctgaaag gcatcggcag aaaatacgat 656341 gactcgaatt gcggacagtg tctcgcttgc tttacaggaa aatatccgac tgaaatttac 656401 caggatacag tgcttcctca cgtaaaagaa gcagtattaa ccaaataaaa cttgaaaaat 656461 gacataaagg cagcgcagtt cggctgcctt tctctttctg ccctcgttcg gggagatatt 656521 ttgaaaagcg ccttaaagga gtgaatagga tgtctgaagc atataaaaac gcaggagttg 656581 acatcgaagc cggatatgaa gctgtaaaac gaatgaaaaa acacgtggag cgcacgaaac 656641 ggcttggcgt tatgggcagc cttggcggtt ttggcggcat gtttgacctg tctgagcttt 656701 cttatcaaaa accagttctc atttcgggaa cggacggtgt cggcacaaaa ttaaagctcg 656761 ctttttccat ggataagcat gacacgattg gcgtggatgc tgttgcaatg tgtgtcaatg 656821 acgtgctggc acaaggtgca gagccgctgt ttttcctcga ttatttagcg gttggcaaag 656881 cggacccagt gaaaattgaa cagattgtac aaggtgttgc ggaaggctgt gagcagtcag 656941 gttcagcctt agtcggcggt gaaacggctg aaatgccggg gctctataca gctgatgaat 657001 acgatattgc cggtttctca gtcggagtgg cagaaaagga cgaaatcgtg actggagaaa 657061 aaattgaaga gggccatctg ttgatcggcc tcagctccag cggccttcac agcaacggct 657121 tttcccttgt cagaaaagtg cttctggatg atgcggagct ggacctcgat acaacatatg 657181 agccgtttga acgcccgctt ggcgaggaat tgcttgaacc gacaaggatt tacgtgaagc 657241 ctgtgcttgc cgcggtcaaa agcggaaaaa tcgacggcat ggcgcacgtg acaggcggag 657301 gatttattga aaatattccg cgtatgcttc cggaaggctt aagtgcggaa attgatcatg 657361 gctcatggcc gatcccgccg attttttctt tcttgcaaga gtacggcaag ctaaaggaag 657421 aagacatgtt caacgtcttt aatatgggta tcggttttgt tttggcagtc aaagaagagc 657481 atctgacaga tgtgatcgga acgcttgaaa gccatggcga aaaagcctat ttaatcgggc 657541 gtgtgaaaaa aggtgaaggc gtcacattcg gcggtgcggc actttcatga aaaagtttgc 657601 ggtatttgca tcaggaaacg gttcaaactt cgaagccatc gtcacgcgtt tgaaggagga 657661 gaactgggat gcgtcagcag cgctcctcgt ttgcgacaaa ccgcaggcga aagtcatcga 657721 acgggcggaa gcattccaca ttccatcctt cgcatttgag ccgaagtctt atgaaaacaa 657781 ggctgcattt gaacaagcca tcattgaaca gcttcgtctt cacgaggttg aattgattgc 657841 tcttgccggc tatatgaggc tgatcggtga tacgctcctt caagcatatg ggggaaaaat 657901 cattaacatt cacccatcgc ttcttccggc gtttcctgga atcgacgcag tcggacaggc 657961 gttccgggcg ggtgtgaagg tggccggaat caccgtgcat tatgtcgatg aaggaatgga 658021 tacaggtccg atcatcgctc aaaaggcaat cgaaattgat gaacatgata cattggaaac 658081 aatcgaacag cgaattcaca agcttgagca taaatggtat ccgagtgtga ttaaacagct 658141 attaggatta aataacagag gtgaaaaggc atgaccatta aacgtgcatt aatcagtgtt 658201 tcagataaaa caaatctcgt tcctttcgta aaagaactga cagagcttgg cgttgaagtc 658261 atctccacag gcggaacgaa aaagcttctt caagaaaacg gtgtggatgt gatcggaatt 658321 tctgaagtga caggctttcc tgaaattatg gacggccggt taaaaaccct acacccgaat 658381 attcacggcg gccttctggc ggttcgcggc aatgaagagc atatggcgca gatcaatgaa 658441 cacgggattc agccgattga cctcgttgtc gtcaacctct atccatttaa agaaacgatt 658501 tctaaagaag acgtcacgta tgaagaagcg atcgaaaata tcgacatcgg cggacctggc 658561 atgctgcgcg cggcatcaaa gaaccatcag gatgtcacgg ttatcgtcga tccggccgat 658621 tacagcccag tgctaaatca aatcaaagaa gaaggcagcg tatctcttca gaaaaaacgc 658681 gagctcgcgg caaaagtatt ccgtcatact gcggcatatg atgcactgat cgctgactat 658741 ctgacaaatg ttgtcggtga aaaagaacca gagcaattca ctgtgacatt tgagaaaaaa 658801 caatcgcttc gctatggaga aaacccgcat caggaagcaa ctttctatca aacagctctt 658861 cctgtcaaag gctccattgc gcaagcagaa cagcttcacg gaaaagagct ttcttacaac 658921 aacattaaag acgcggatgc tgcagttcaa atcgttcgtg aattcactga accggctgct 658981 gttgctgtga agcatatgaa cccgtgcggc gtgggaacag gaaaaacgat cgcagaagcg 659041 tttgacagag cgtttgaagc ggataaaaca tctatcttcg gcggcattat cgcgctgaac 659101 cgtgaagtgg acaaggcaac tgccgaagcg cttcacaaca ttttcttaga aatcatcatt 659161 gcgccttcat tcagccaaga agcgctcgac gtcctgactg cgaagaaaaa tctccgtctg 659221 ctgacgcttg acgtatccgc cgctgttcaa aaggaaaaac agctgacatc cgttcaaggc 659281 gggctgctga ttcaagattt agatatgcac ggcttcgatg atgctgagat tagcattccg 659341 acaaaaagag agccgaacga gcaagagtgg gaagacttga agcttgcttg gaaagtcgtg 659401 aagcatgtga aatcaaatgc gattgttctc gcgaaggaca acatgacagt cggcgtggga 659461 gcaggccaaa tgaaccgcgt cggatcggca aaaatcgcaa tcgagcaagc aggggaaaaa 659521 gcgaagggca gcgcgctcgg ttcggatgca tatttcccaa tgccagatac tgtcgaagaa 659581 gcggcaaaag cgggcgttac agccatcatt cagccaggcg gatcgatccg agatgaggat 659641 tccatcaaaa aagcggatga atacggcatt gccatggtat tcaccggcat cagacacttc 659701 aaacattaag gggatgaaaa cgacgtgaat gtattaatta tcggtaaagg cggaagagaa 659761 catacgctgg cgtggaaggc agcgcaaagc agcctcgtcg agaatgtatt tgccgctccc 659821 ggaaatgacg gcatggcagc ttccgctcag cttgtaaaca ttgaggaaag cgaccacgca 659881 gggcttgtct catttgcaaa acaaaatcag gtcggcctga ccattgtcgg ccctgaggtt 659941 cctttaattg aaggtctggt ggatgaattc gaaaaagcgg gcttacatgt gttcggtccg 660001 tcaaaagctg cggcgatcat cgaaggaagc aaacagttcg ctaaggattt aatgaagaaa 660061 tacgacattc cgaccgcaga atacgagacg tttacatcct ttgatgaggc gaaggcatat 660121 gtgcaggaaa aaggtgctcc gattgtgata aaagcagatg gacttgcagc tggaaaaggc 660181 gttactgtgg ctatgacaga ggaagaagca attgcgtgct tgcatgactt tcttgaagat 660241 gaaaagttcg gtgatgcgag cgcgtccgtt gtcattgaag aatatctttc tggtgaagaa 660301 ttttctctaa tggcctttgt caaaggggaa aaggtgtatc cgatggtgat tgcccaggat 660361 cacaagcggg cgtttgacgg agacaaaggc ccgaatacag gcggcatggg cgcctactcg 660421 ccagttccgc aaatttcgga agaaacggtc cgccatgctg tagaaacgat cgttaagccg 660481 gctgcaaaag caatggtaca agaaggccgt tccttcactg gcgttttgta cgctggattg 660541 atgcttactg aaaacggctc gaaggtcatt gaatttaatg cccgtttcgg cgatccggaa 660601 acacaggtcg tgcttccgcg catggaatct gatctggtac aggtgcttct tgatctttta 660661 gatgataagg aagttgactt aagatggaag gataccgcgg cagtgagtgt tgtgcttgca 660721 tcagaagggt atccggaaag ctatgcaaaa ggcacgccga tcggcagcct tgcagcagaa 660781 actgagcagg tcgtggtctt ccatgccgga acgaaagcag aaggtggaga gttcgttaca 660841 aacggggggc gcgtcgccaa tgtgacggct tttgatgaaa cgtttgaagc ggctagagac 660901 cgagtgtaca aagcggttga tgaaattttc aaaccgggac tctttttcag aaaagacatt 660961 ggggcacgcg ctttaaaggc tgcccaaaaa taagtgagga aaacccgcag aatagctgcg 661021 ggttttttgt tatcaaaaag cgggatggca gctagaagaa gaaagcacaa cgagcgtggt 661081 tggttttcca tgggccatcg aggtgtcaat aaaatcctca agcgtatgta ccgattcagt 661141 cacgaccttt gtcacatagc tgtacatccc cgtgatgcgg tggttttctg ctacatcagg 661201 atgcgatgtt gcaaaggcgg cgtagtgctt gcagcttttc ggctccatga gaataaaagc 661261 ggtgacatgc ttgtttagtt tttcgtaaca gatattcgcg ctgtagccgg taatcactcc 661321 tttgtcttcc agcttcctga cacgctccgc cgcgcttggc gagctgagtc cgacaagctt 661381 tcccagctca accatcgtta atctgccgtt tcgctgcaaa tgcgagagaa tctgaaggtc 661441 tgtatcgtcc atttgtctgg ctcctttaca tatttaggcg aatgaatgaa aattcctttg 661501 atcgtaaggt aatgctgttg atttaacttc attgtagcat atggatgccg tcttattttt 661561 tctataataa agccatcaat cagagagggg gcatcatgtt gccagaattg cagcgctcta 661621 ttacttggat acaagggacg gcgttaacga ttggggcggt tttaggatgc gggatattaa 661681 tcctgccgtc tgtcaccgcg gacacggccg gccccgcttc tttatttgtt tgggtgttca 661741 tgtccttctt atcctttttt cttgtcggca cgctggcccg gcttgtgaaa atagcgccta 661801 gcgcgggagg aatcacggct tatgtgcagc tggcctttca gaaaaaagcc ggggctattt 661861 tgggctggat catgttaggg tccgttccga tcggcgttcc catcatcgct ttgactggcg 661921 cgcattacgt cagttacatc acagaggcgg ccgattggca gattacattg attgctggtt 661981 gcatgctggc tatatctatt ttgcttcata tgagagggat tcaactatca gcaaacatta 662041 gtacactcgt tatatgtgtc atcgtatttc tgcttgtcac ttctattgct gtgtcattgc 662101 cacacgtcac gatagcagaa ttcaagccgt ttcttccgca tggctggtct gccgctggat 662161 ctgtttctgt tatgattttt ttctcttttg taggctggga aatgattacc ccgttggctg 662221 aggaatttca tcgtcctgaa aaagatgtcc cgctcagctt gtttttggca gcgtcttgtg 662281 tggcggggct gtatatcatg ctgtcatttg tgaccgtggg tactcattca tatggagaga 662341 atggagaaat tgcatcgctt gccatgctca tttcaaaagg agcaggagaa agcggtgtat 662401 atgtcacggt atgtttagcg ctgtttatta cattcgccac catccatgcc aatattgccg 662461 gtttttcaag aatggtgtac gcattggcga gagaggggca catacccgta ttttttggaa 662521 aactcagtgc gacaaaacgt acgcctattc gcgttttgac agcgatggcc gcagtgtttg 662581 gcttagtgct tgcagcgcat ggtctgtttc aaatcgattt gacgactctg ttgaaagggc 662641 cgagcgcggc ttttatcgca tcttacatat gtacaatggc ggcagcactg aaactgctgg 662701 gcaggagaga tataggctgg tggatggcgc tcggggcatt tgtggcgtgc gcggtgattt 662761 attcattcag cggctgggca ctgctttatc cggcagtgct ggcagctgca ggatatttct 662821 atatgaaaac aaagggtggg cataaaaaaa agcttgatca cgttttgtga tcaagctttt 662881 ccatttatcc gttttgatgc tcgttatttc cagaatcgct gtgttgaaac atgtaggtca 662941 caggacagaa gcgcaagatt cccgaacccg ctttcatggc ccccataaag atgtaaaaga 663001 gatgcattct gcaccaaggt tttttcgtaa actttgcact ggcggctgac ataatcgtca 663061 atccgcaggc gattctgaac acggcattga tgagactgat gtttggcttc aaggaaatcc 663121 gctcctttta cttaaaaaag ttttttaatc gaaccttcaa aaatttgtaa cgtttttatc 663181 gtgcgtgatg aggaaggatg tgataccatg agtctaatac atgtaaagga gagtatgtga 663241 atgtccgaac gcacctttaa ctggaaaaac aaagacatca gggcacaggt tgatgttgta 663301 gactcaaagc tgcttccaac gctcctttta cggaatgctc tcgtcttaaa tccatatgta 663361 aaacaatggc tgaaaaaaaa catttggatt tatcaggacc gcattgttta tgtgggtcat 663421 gaacttccga atagagccga agaaattcat acgattgatt gtgaaggaaa atacattgtg 663481 ccaggttata ttgaaccgca cgcacatcct tttcaaatat ataatcccca aacactggcg 663541 gaatatgtgt ctcaatacgg aacaacgaca ttcgtgaatg ataacttatt tttgcttttg 663601 caaagcggaa aaaagaaagc gcttacgatt ttgaatgaac tcaaaaagca gcctgtccag 663661 tatttttggt ggtcacgcta tgacctccag accgaggttc tgaacgagga ccacgtcctt 663721 ccatttgacg tcagaaaaca gtggattgaa catccggatg tgattcaagg cggagaaatg 663781 accggatggc ctcgcctggt agatggtgat gatttaatgc tccactgtat gcaagctaca 663841 aagaaacaga gaaaacgtat tgaagggcat tttcccggcg cttctgataa aacgcttaca 663901 aaaatgaagc tgttcggtgc ggattgtgat catgaagcga tgacaggtga tgaagtgatg 663961 agaaggctgg aactgggcta ttatgtttcc cttcggaact cttccattcg ccccgatgta 664021 agaaaaatct tgcaagagct gcatgagaag ggcttccgct attatgacca cttcttttac 664081 acgacagatg gcgcaacccc gaatttctat aaaggcggca tgacaaacga gctgattcgc 664141 attgcgttag aagaaggcgt acctgcaatc gacgcctaca atatggcatc atttaatatc 664201 gcaaagtatt accaaatgga tgattattta ggagttgtcg gaccgggcag actggcatcg 664261 ctaaacatac tggaagatcc gttaaatccg aatccagtga ctgttctgtc aaaagggacc 664321 attctgcgtg aaaacggctg tgatttgaag gcgtttacaa agacggactg gcacaaaggc 664381 ggtcttgtcc cgcttgagct ttcatatgat atgacgatgg atgacttgca gttttctatg 664441 ccgatgggcg tgaaaatgcg gaatgcggtt attatggagc catatatgat tgagatcgac 664501 aattcgatgg aacagctctc gtttgaccat gatgaaagtt atttgacgat gctcgacaga 664561 cacgggaaat ggcgcgtcaa tacgatgata aaagggtttg cctcaagcgt gcagggattt 664621 gtaagctcct ttacgacgac gggcgacatt gtcgcgattg gaaaaaataa agcggatatg 664681 ctgctcgctt tcgcccgcat gaaagaaatc ggaggaggaa ttgttttagc ggagaacgga 664741 aacattctgc atgaaatccc gcttgcgctg tgcggctgcg cctcttcgga agcgtatgaa 664801 gacgtgcttg agaaggaaca aaagctgaga gatcttttga ctgaaagagg ctatgagttt 664861 tgcgatccta tctatacgct gctctttttg caaagtacgc accttccgta tatacgcatt 664921 acgccaagag gaatattcga cgtcatgaaa aaaactgtac tctttccatc gataatgcgt 664981 taaaatataa aagagcaggg agccgacata tgaaaaaatg gatgacagtt tgcgcgctgt 665041 gtttcgtgtt ttttctgctg gtatcctgcc agcagaagga tgctgtcccg gatactgcaa 665101 agaagctgaa agctccttta acggggctaa agactgaaca gaaagtgact gaacgccgcc 665161 ctgttgctgt tgtggtgaac aatcacccga aggcgaggcc gcagtcgggt ctgtctaaag 665221 ccgacattgt catagaagcg ctagccgaag ggcaaatcac aagatttctg gccattttcc 665281 aaagccagat gcctgaaact gtcggacctg tgcggagcgc gcgggaatat ttcgtcactc 665341 tcagcaatgg ctttgacagc atatttgtcc atcacggctg gagtcccggc gccaaaaagc 665401 agctggaatc cggagctgcc gattatatga acggattgga ttttgacgga agcttatttt 665461 ggagagctga tttcagcaaa ccgccccaca attcctatac gtcttatgat tacataaaaa 665521 aggcggcaga acaaaagggt tataagctga agcaggaaac aaatccgctg ctgtttcaaa 665581 catcagatgc aaaacctgca aatgaatctt acaatgttcg ggtagattat ggaacaaata 665641 acgttacaaa tcttgtcgaa tacaactatg ataaaaaagc tgaattttat acaagaagct 665701 ctgatggtgt cataacgaca gaccgggaaa ccggaaagcc ggttgcaatg caaaatattt 665761 tcattgttga agccagccat catattattg atcaagatgg aaggcgggac atcgacttgg 665821 aatcaggagg aaaaggtctg ttgtttcagc acggaaacgt cattgaaaca gactggaaac 665881 aagtgaatgg cagaattgtg ccggtaaaag acggcaagtg gcttccgttt gtgccaggaa 665941 agacttggat caatatcgta cctgatcttg atgcggcttc cattagtaaa ggagaaggtg 666001 tgtaacgatg caaatcgata aattacgcgg caaagagctg gaccagttat ttaactcgat 666061 cttatcgctg aaagacctgg aggaatgtta ccgattcttc gatgatctat gcacaattaa 666121 cgaaattcaa tcgctggctc agcgccttga agtggcgcgc atgcttcgcg aaggaaacac 666181 gtatcataag attgaaacag aaacaggcgc ttccacggct acgatttccc gtgtgaaacg 666241 ctgcttaaat tacggaaatg acgcttatga aatggcgctt gaccgtgtga aggagacgga 666301 aacagagtct tcttccaaat aaaaaaccgc cctgccgtct ggcaagggcg gtttctttat 666361 gaaacaaatt gatggatcag gttgtcgata ttgatgatac tgccatcctc tttccgatag 666421 acaacatgct ccttggaaaa atgaatcggc gaattaatcc ctgctgcggc tgcaaggtta 666481 aatagtccct cgcgcaatga aataacgtag ttgcagacac gatgctgttt ttcctcaacg 666541 ctcagtgctt tttgcaattt cggatctgtc gtcgccacac ctgccggaca ggtgttggtg 666601 tggcagacga gagcgcggat gcagccaacg gaaaacatca tgccgcgtgc gatgttaaca 666661 aagtcagcgc cgagggctaa ggcgaccgcg attttatcag gagtcaggag ctttccggaa 666721 gcaaagattt tcagctggct gcgcaagccg tactgtttaa gaagcgtgtc cacaataggc 666781 agcgctgtca taatcggaag gccgactgta tccgcgagct cgtaaaagga agctccggta 666841 ccgccttcac ttccgtcgat cgtgataaaa tccggatgct ttccgctttt ctgcatatga 666901 gagaaaagct catgcaattc ttcaggatgc cctgcgacca gtttgatgcc gactggcttt 666961 tgtccgacat ctctaagttt ttcaataaag tcgagcattt caggagggtt tgagaattca 667021 taaaagcggt tcgggctgtc aatcgacttt ccaggttcga cattccgaat gtctgccact 667081 tcctctgata ctttggcgcc gtccacatgg ccgccgcggg ttttcgctcc ttgtgccagc 667141 tttagctcaa acgctttaat ctggtcaatc ctgctttttc ttttaaattc ctcccacgaa 667201 aattccccgt ttcttttgcg cacgccgaat aggcccggtc cgatttggca aatgatatcg 667261 gcgccgccct ttaagtgata ttcagacaat cccccttcac ctgtattcat ccaggtgccg 667321 cctgccagat ggagcccttt tgagagcgcc gtaacagccc gttctccaag agaaccgtag 667381 ctcatggcag actggccgac taagcccttc acataaaatg gcttctcgca tgtatgctcg 667441 ccaatcacct gtacatcatc aggatggaga aaatacgggt ctgccttgat atgttcggca 667501 tgctccttgc gtttgaacag attgtcagca tccattttat agatttgggt ttcaattttt 667561 ggcgtttgat ttacatgcat ttcttccctt tgttttggaa acatagcgtt acggatataa 667621 tagccaggtt tatcaaaatc tcttacagat ccaaagccca tcattctgct tttgtatttg 667681 ccggagatga cggtttgctc atattccttt cgtgaaaatg gctgctcttc attgtcattg 667741 ctgtataaat actgtctgag ctccggcccg attttttcaa ggatataccg aaaccttccg 667801 atgacgggat agttgcgaag aattgagtgc tcctgctgtt tttcatcctt tatgtagatc 667861 caggcaaaca agacgatcgg gatagcgatg atcccaatga taaatgcgat gagtgctatt 667921 atgatggttt ccatctctca gcctcccttt ttatgtaacc atttccacag tagaacactt 667981 tccaaacaat agcagaagga atctggtgaa aaatgtgtgc tcctgccgat acaggactca 668041 ccatgcaggt actgccatat gctctctttt tttatgaaaa aagaatcaaa acaccttttt 668101 cagtgaataa cgagattaac ggctttttcc gtttttccgc gctatgtgaa tttgttataa 668161 tgtttaaatg gtaacaaacg aatggaggaa cgtatgacgt gtacgatgta acggagtgga 668221 agcatgtctt taaactcgat ccaaataaag atttgcctga cgaacagctg gagattcttt 668281 gcgaatcagg aacggatgcg gtcattatcg gaggaagcga tggtgtgaca gaggataatg 668341 tcctgcggat gatgtctaag gtaagacggt ttttggtgcc gtgtgtccta gaggtatcag 668401 cgattgaagc gattgttccc ggctttgact tatattttat tccgagtgta ttaaacagca 668461 aaaacgcgga ttggattgtc ggaatgcacc agaaagccat gaaggaatac ggagaactga 668521 tgtctatgga agaaatcgtg gcggagggct actgcatcgc aaatccagat tgcaaagccg 668581 cggcactgac tgaagcggac gccgatctga atatggatga tattgtcgcc tatgcgcgtg 668641 tgtcggagct gctgcaactg ccgatttttt atttagaata cagcggcgtg cttggagaca 668701 tagaagctgt caagaaaacg aaggctgtat tggaaacgtc caccttgttt tacggcggcg 668761 gcatcaagga tgcggaaacg gccaagcagt acgcagagca tgcggacgtg atcgttgtag 668821 gcaatgcggt gtatgaagat tttgacaggg ctttgaaaac agtagcggct gtgaaaggcg 668881 agtagtaaat tgtacggatt tggtttatga tagaacgtat gttttgtata ggcgggtgaa 668941 caaattttga attatattag caatcaatta ctaagcggtt taaaccccgt tcagcaggaa 669001 gcagtcaaaa caacggacgg gcctcttttg ctgatggcgg gagcgggtag cggaaagacg 669061 cgtgtcctga cccatagaat tgcttattta atggcagaaa agcatgtggc gccgtggaac 669121 attctggcga tcacatttac aaataaagcg gcacgcgaaa tgaaagaacg tgtggaaagc 669181 atcctcggac ccggcgcgga cgatatctgg atctccacat tccacagcat gtgcgtgcgg 669241 atcttgcgca gagatatcga ccggattggg atcaaccgaa atttctccat ccttgatacg 669301 gctgaccagc tttcagtgat caaggggatt ttgaaggagc gcaatcttga tccgaagaag 669361 tttgacccga gaagcatcct cggcacgatc agcagtgcaa aaaacgaatt gaccgaaccg 669421 gaggaattct ctaaagttgc tggcggctac tacgatcagg tggtcagcga tgtatatgct 669481 gattatcaga agaagctatt gaaaaaccag tcgctcgatt tcgacgattt aattatgacg 669541 acgattaaac tgtttgacag agtgcctgaa gtgcttgaat tttatcagcg caaattccag 669601 tacatccacg ttgatgagta tcaggatacg aacagggcac aatacatgct cgttaagcag 669661 cttgccgagc gtttccagaa cctttgcgtt gtgggggatt ctgatcagtc aatctacaga 669721 tggcgcggcg cggatatcac caacattctt tcatttgaaa aagattatcc gaatgcaagc 669781 gtgattttgc tagaacaaaa ctatcgttca acgaaacgga ttttgcgcgc ggctaacgag 669841 gtcattaaaa acaactctaa ccgcaaaccg aaaaatttgt ggacggaaaa tgatgaaggc 669901 atcaagattt cctattatcg cggtgataat gagttcggtg aaggacagtt tgtggccggc 669961 aaaattcatc agcttcacag cacaggcaag cggaagctgt cggatatcgc catattatac 670021 cggacaaacg cgcagtcccg tgtgattgag gaaacgcttc tcaaagcggg cttgaactat 670081 aacattgtcg gcggcacaaa gttctatgac agaaaagaaa ttaaagacat tcttgcgtac 670141 ctgcgcctcg tatccaatcc ggatgacgat atcagtttca cgcgcattgt caatgtgccg 670201 aagcgcggag tcggcgcgac atcacttgaa aaaatcgctt cgtatgcggc cataaacggc 670261 ttgtcctttt tccaagcgat tcagcaggtt gattttatcg gcgtcagtgc caaagcggca 670321 aacgcgcttg acagctttag acagatgatt gaaaacctga ccaatatgca ggattactta 670381 tccattacag agctgacaga agaaattctt gataagacgg aatacagaga aatgctgaag 670441 gctgagaaat cgatcgaagc ccaaagccgt ttagaaaata tcgacgagtt cctgtctgtt 670501 acgaaaaact ttgaacagaa aagtgaagac aagacactcg ttgcgttcct gacagacttg 670561 gcattgatcg cagatattga tcagctcgat cagaaggagg aagagtcagg cggcaaggat 670621 gcgatcaccc tgatgacact gcacgccgcg aaaggactgg agtttccggt tgttttcttg 670681 atggggcttg aagaaggcgt cttcccgcat agccgttcac tcatggagga agcggaaatg 670741 gaagaagaac gccgccttgc gtacgttggg attacaaggg cggaacagga gctttatctg 670801 accaatgcta aaatgcgcac cttgtttggc cggacaaata tgaacccgga atctcgcttc 670861 attgctgaaa taccggatga tttattggaa aacctaaatg agaaaaaaga aacaagagcg 670921 acgtctgcga gaaaaatgca gccgagacgc ggccctgttt cacgcccggt atcctacgcc 670981 agcaaaacag gcggcgacac cttgaactgg gcagtcggag ataaggcggg ccataaaaaa 671041 tggggaacag gaactgtcgt cagcgtgaaa ggcgaaggag aagggacaga gcttgatatt 671101 gccttcccga gccctgtcgg cgtgaaacgc ctgttagcag catttgctcc tattgaaaag 671161 cagtaattga agaggaaagg aagaagcaga tggacaaaga aacagcgaag cagcgggcag 671221 aagaactgcg ccgcaccatc aacaagtata gctatgaata ttacacctta gatgaaccga 671281 gcgtcccaga tgccgaatac gacagattga tgcaggagct gatcgcgatc gaggaggagc 671341 acccagacct cagaacgcct gactctccta cgcagcgcgt cggcggagcc gtgcttgaag 671401 cgtttcagaa agtcacccac ggcacaccga tgctcagtct gggcaacgcc tttaatgctg 671461 atgatcttcg tgatttcgac cgccgtgtgc gccagtccgt cggcgacgat gtggcgtata 671521 atgtggagct gaaaatagac ggtcttgctg tttctctccg ttatgaagac ggctattttg 671581 tcagaggggc cacaagaggt gacgggacga cgggagagga tatcacggag aatctgaaga 671641 cgatccgcaa tatccccctt aaaatgaacc gtgagctgtc gatcgaagtg cgcggcgagg 671701 cgtatatgcc gaagcgttcg tttgaagcac tcaatgagga acggattaaa aatgaggaag 671761 aaccgttcgc caatccgcga aatgccgcgg cgggatctct cagacagctc gatccgaaaa 671821 ttgcagcgaa acgaaacctc gatatcttcg tctacagtat agcggagctt gacgagatgg 671881 gtgtagagac gcaaagccaa gggcttgatt ttctcgacga actcggattt aaaacgaatc 671941 aggaacgaaa aaaatgcggc agcatagaag aagtcattac gctgatcgat gagcttcagg 672001 cgaagcgcgc ggacctgccg tacgaaatag acggcattgt cattaaagtc gattctctcg 672061 atcaacagga ggagctcggt tttacggcga aaagcccgcg ctgggccatc gcgtataagt 672121 ttcctgctga agaggtcgtg acgaagcttc tcgatatcga attaaatgtc ggcagaacgg 672181 gtgtgattac gccgactgcg attcttgagc cggtaaaagt tgccggcaca acggtctcaa 672241 gagcatccct tcataacgaa gatttaatta aagagaagga cattcggatt ttggataagg 672301 ttgtcgtcaa aaaagcgggc gatatcatcc cggaagttgt gaatgtcctc gttgaccagc 672361 gcacaggaga agaaaaggaa ttcagcatgc cgacggaatg tcctgaatgc ggcagtgaac 672421 tcgtccggat cgaaggagaa gtggcgcttc gctgcattaa ccctgaatgt ccggcgcaaa 672481 tccgggaagg gcttatccat ttcgtttccc ggaatgccat gaacattgat gggctcggcg 672541 aacgagtgat cacacagctg tttgaggaaa accttgtccg caatgtggca gatttatata 672601 agctgacgaa ggaacgagtc atccagctcg agcgcatggg cgaaaagtcc actgaaaacc 672661 tgatcagctc catccaaaaa tcaaaagaaa attcgttaga gcgcctgctg tttgggcttg 672721 gcatccgttt tatcggatca aaggccgcaa agacgcttgc catgcatttt gaaagcttgg 672781 agaacctgaa aaaagcctct aaagaggaac ttctcgcggt agatgaaatc ggtgaaaaaa 672841 tggctgatgc tgtgatcacc tattttcata aagaagaaat gcttgaactc ttgaatgaac 672901 ttcaggagct gggcgtaaac acgctctaca aaggcccgaa aaaagtaaaa gcagaggaca 672961 gcgactctta ctttgctggt aaaacaattg ttctgacagg aaagctggaa gagctgtcaa 673021 gaaacgaagc caaagcgcaa atcgaagcgc tgggcggaaa gctgactgga agcgtcagca 673081 aaaacacaga cttagtcatc gccggagaag cggcgggaag caagctgaca aaagcacaag 673141 agctgaacat tgaagtgtgg aatgaagaac agttaatggg agagctaaag aaataagagg 673201 agtgttttct attgaaaaag acgttggcat tggcggcaac ggcggcagta ttaatgctgt 673261 ctgcctgctc gtcaggtttc gggggggaga aggaggaaga gattacgcaa aagacggcga 673321 aatcgtcaga aaaagcgatt gtcccgaaat ataatatctc tgactcctat tacaaaatgg 673381 tgctgccgtt taaggcaggc aaagcgcgcg gcttaacaac ggaacagctg aatacaaggc 673441 tggacattga cgaatttgaa acagggctga tgcgccttgc ccaagattct ttctcaactg 673501 acgattatct gttccaagaa ggacaatatt tagatgagga tacagtatta agctggctgg 673561 cacggaaaaa aacgggctct gatttgaaaa aagccgaaaa agaagataag aacttcaaaa 673621 atgaaggctt gaacccggcg ctcccgagtt ctggttcaac agaagaaaag aacgaaagca 673681 gcccaattta tttagcatcc atgcttgagc acgattattt agtcagaaaa gacaagaatt 673741 ctatccagct tggcggcgtc atgatcggac tggcgttaaa ctcagtgtat tactatcgtg 673801 aaaaaactgg cgacccgcaa aaagaagtgg agattaaaga cagcacgctt cgccagcagg 673861 gagaaaaaat tgcacaggag gttattaacc gcctccgcaa aaaagataac ttgaagaatg 673921 tgccgattac cgtggcgctc tacaagcagg cgtcaaaaac atcgattgtg ccggggaact 673981 tcatcgccaa aacagaggtc aaagcaggct ctactgatat ctcaaattgg gatgacatca 674041 atgaaaaata tgtattctat ccggcggata caaccacagc agaaaagtac ccggatgaca 674101 ccgaggtctt taagcggttc aaaaactcaa ttgaagaata tttcccgaac tatacaggcg 674161 ttgtcggtac agcgctgtat gaaaatgatg aaatgaagaa aatgaagatt gacataccaa 674221 tgcaattcta cggaaaaagt gaagttgtcg cgtttaccca gttcttaacg ggtgaagtga 674281 tggactacta ctctaagagc tcagttgatg tcgaagtcaa tatcacgtcc tcagacggac 674341 aggaagcggt cattatccgc aatgccggag ataaagagcc gactgttcac atttatgact 674401 gatagaaaac ccttgtgcca tattggcaca agggttttta tgttacaatt aacaggaaaa 674461 gggaaaatat tttcacttct gccgaaacac aaatcaaggg gaggtatgtt gatgctggaa 674521 atcgtgtgaa aacaatcatt atcaaatcta tagcaatgaa aggatgttag acgtgcataa 674581 agatatcaaa aaaatatttc atgaagagca ggttttggca gaagctgcag cgagatacgg 674641 tttctcaaaa gatcaggtgc gttttctggc tgatgcggaa aactatgtat atgaatgtat 674701 gaaagacaat caaccttata ttttaaagat tacccatacg attcggagat cttctgatta 674761 tatgatggga gagatggaat ggctccgtca ccttgcaata gggggaattt cagtagccaa 674821 accgctcccg tcgctgaacg gaaaagacgt agaagcagtg ccggacggaa acggcgggtc 674881 atttttattg agagtgtatg agaaagcgcc ggggcaaaaa gtggatgaat cggactggaa 674941 tgaaacgcta ttttatgagc ttggcagata cacaggcagc atgcacagcc tgacaaaaag 675001 ctacaaattg agcaatcccg ctttcaaaag acaggaatgg gatgaagagg agcaattaaa 675061 gctgagaaaa tatgtgcctg aagatcagat aaaggtgttt cagcaagccg attctttgat 675121 gaatgaactg cggaggctcc cgaaaagcca ggacaactac ggcttggtgc atgcggatct 675181 gcaccatggc aattttaact gggatcatgg caaaatcacg gcatttgatt ttgatgatat 675241 cggctacaac tggtttgtta acgatattag cattcttctc tacaatgtcc tgtggtatcc 675301 tgttgtgcca tatgatgata aagctgcgtt tacagaagaa tttatgacgc attttatgaa 675361 agggtactgg gaggaaaatg agcttgaccc tgcatggctg atgataatac ctgatttcct 675421 ccgccttcgc catatgctga tttacggatt gctgcatcag atgtttgacc ttaacacaat 675481 aggagaagag gaaaaagaaa tgctggccgg tttcagaaga gatatagaga atggcacgcc 675541 gattacagca tttgattttt cagcactggt gtagatagaa aaagccaatg ggattccagt 675601 cccattggct tttataatgt atcacacttc acgccgacta cgccttcaat ggctttaatg 675661 tcatagtaga catcggtcgt gtatctgttt ttatggacgc ggaccttcac ttccataatt 675721 ggaaaatcct tttcgcctag gtcgtcgatc cgaacggagt gtgctttgat atctcttctt 675781 ttcatttctt ttaaaatctc tgtcattttg tctttatcag aaagtgacat tctgatgcgg 675841 atgtcttttt cctgcaggcg gtcggggccg atttttctga ccacccatgg gagaaattcc 675901 acactgatca ggatgaacag aagactggca aacgcttctt tataaaaacc ggctcccgta 675961 gcaagcccga gccccgctgc cccccagatc atggccgatg tcgtcaggcc ggaaatgaca 676021 tcattgcttt ttcgcaggat gacaccggcg ccgataaacc cgacgccgga gatgatttgt 676081 gccggcagac gaagcggatc catcatgatg cggtagtatt tagggaaatg atatgccgca 676141 ttaatactga cgatcgtcag catgcatgag ctgactgcga tgacaataca ggtttttaat 676201 ccgagcggct tattttttaa ttcgcgttca agcccgatga ccatgccaat caatgtggca 676261 atgcccaatt tcaataaaat atcaggatca atataccagc tcaacagcaa acttccccct 676321 tctctatggt gtttttaaat aaatatgatt ttctcacagt atttatagca aaacaagagc 676381 acaaaagcca ccaagctgcg cttgatggct tattgcttac tttttgcgtt ttaacagctt 676441 ttccatgaca ccgaataatc ggtaagaggc ttttgcagga cgttttgtga tcatgctgac 676501 aatgatgccg gcaatcatac tgagaataaa cccagggatg atttcgtaca caccggttga 676561 ttttgccagg ccggttgtaa tccagatcaa cacggtcgca gccccgacaa tcatggcagc 676621 aagcgcgccc cattcgttca ttcgtttcca atacagactg agcagaatcg caggcccgaa 676681 agctgaaccg aagccggccc aagcgtatcc gaccaaatca agaatggtgc tgttcgggtt 676741 caatgacaag agtaccgcga taacggcaat gactaagacg gacaatcgcc cgatcatgac 676801 caattcttta tcagaagctt ttcgtctgaa aaatgaccgg tataaatcct ctgttacagc 676861 acttgctgtg accaagagct gtgaggaaat cgaactcatg atggcagcca aaatagctga 676921 caataagaac cctgtaatta atgggtggaa caagatttta gagaagataa tgaaaatcat 676981 ctccggatct tttacagcaa ctccgaattt atgggcgtat gcaacaccga ttaaacccgt 677041 cagcacggaa cctagaactg taatgatcat ccagctcatg ccgattcggc gtgcaggttt 677101 taaatcttta atgtctttaa tggccataaa tcggacgatg atatgaggct ggccgtagta 677161 gcccaacccc caggctaaat aggaaataat gctaatgacg ctcgcgcctt taaaaatatc 677221 caataaatgt ggattaacag cgtcgatttc atggaaagtc ggagcaacgc cgcccacatg 677281 ggtaaaagca acgatcggca caagcactag tgctgcaaac atgatcgcac cctgcacgaa 677341 gtcagtcaga ctgacagcaa ggaaaccgcc aaacagtgtg tataacacga caactgcggt 677401 ggtcagaaac aggcctaatt tgtaatccgc accaaaagca gattcaaaca gccgtccgcc 677461 agataccata ccggaagagg tatacaatgt gaaaaagatc atgatgatca atgcagatac 677521 gattttcagc agtgatgaag aatgctggaa tcgtttatca aagaaatcag gaattgtaat 677581 cgcatcatct gccgcttctg tataagcacg cagccttgga gccagcagca agtaatttga 677641 gtacgccccg attgtaagac ctaaagcaag ccataaggtg gacagccctg tcgcaaacat 677701 cgcgccggga acacccatca gcatccatcc gctcatatcg gccgcgccgg cagacaaagc 677761 agtaacgaat ggtccgaggc ctcttcctcc aagcatgtaa tcattgatgt cagtggtttt 677821 cttgaatgca taccagccga ttaacagcat ggcaataaag taaattccta aagatataat 677881 aatttcaata ctcacgtttt accctctctt catttctaat aatgttgcat cacctctcaa 677941 attgatggtg ccagttaagc agcctggcgt aagtgcaaaa caaaagaaat tcttttgcgg 678001 gtgcacttgg taacttaacc taacaaagta ttcccggcca ttcaagcgat gaaacattga 678061 tcataagctg gaaataccgt tgcaaaccta gaagggaata aagaataaaa cgctttcaaa 678121 aaataattaa agtaaaaata ttcagaaaaa tatttcgttt ctccttctcc tcattttagt 678181 ataaaatata tagggtattg tttcgaaaac acaggcctgt ctcaaggcgt tttgttgctt 678241 taaagggctt gtttttgata tgatcagtat tatatgactt aacggagaaa tatgtggagg 678301 tggatcatat gtcacgaatt tcaatagaag aagtaaagca cgttgcgcac cttgcaagac 678361 ttgcgattac tgaagaagaa gcaaaaatgt tcactgaaca gctcgacagt atcatttcat 678421 ttgccgagga gcttaatgag gttaacacag acaatgtgga gcctacaact cacgtgctga 678481 aaatgaaaaa tgtcatgaga gaagatgaag cgggtaaagg tcttccggtt gaggatgtca 678541 tgaaaaatgc gcctgaccat aaagacggct atattcgtgt gccatcaatt ctggactaaa 678601 ggagggacac aagaatgtca ttatttgatc ataaaatcac agaattaaaa cagctcatac 678661 ataaaaaaga gattaagatt tctgatctgg ttgatgaatc ttataaacgc atccaagcgg 678721 ttgatgataa ggtacaagcc tttttggcat tagatgaaga aagagcgcgc gcatacgcga 678781 aggagcttga tgaggcggtt gacggccgtt ctgagcacgg tcttcttttc ggtatgccga 678841 tcggcgtaaa agataatatc gtaacaaaag ggctgcgcac aacatgctcc agcaaaattc 678901 tcgaaaactt tgatccgatt tacgatgcta ctgtcgttca gcgccttcaa gacgctgaag 678961 cggtcacaat cggaaaactg aacatggacg aattcgccat ggggtcatct acagaaaact 679021 cagcttacaa gctgacgaaa aacccttgga acctggatac agttcccggc ggttcaagcg 679081 gcggatctgc agctgcggtt gctgcgggag aagttccgtt ttctcttgga tctgacacag 679141 gcggctccat ccgtcagccg gcatctttct gcggcgttgt cggattaaaa cctacatacg 679201 gacgtgtatc tcgttacggc ctggtcgcat ttgcgtcttc attggaccaa atcggaccga 679261 ttacacgtac ggttgaggat aacgcgtttt tacttcaagc gatttccggc gtagacaaaa 679321 tggactctac gagtgcaaat gtggacgtgc ctgattttct ttcttcatta actggcgaca 679381 tcaaaggact gaaaatcgcc gttccgaaag aataccttgg tgaaggtgtc ggcaaagaag 679441 cgagagaatc tgtcttggca gcgctgaaag tccttgaagg tctcggcgct acatgggaag 679501 aagtgtctct tccgcacagt aaatacgcgc ttgcgacata ttacctgctg tcatcttctg 679561 aagcgtcagc gaaccttgca cgctttgacg gcatccgcta cggctaccgc acagacaacg 679621 cggataacct gatcgacctt tacaagcaaa cgcgcgctga aggtttcgga aatgaagtca 679681 aacgccgcat catgctcgga acgtttgctt taagctcagg ctactacgat gcgtactaca 679741 aaaaagcgca aaaagtgcgt acgttgatta agaaggattt cgaggacgta tttgaaaaat 679801 atgatgttat tgttggaccg actacaccga cacctgcgtt taaaatcggt gaaaacacga 679861 aggatccgct cacaatgtac gcaaacgata tcttaacgat tccggtcaac cttgccggcg 679921 taccgggaat cagtgtgcca tgcggattag cagacggact tccgctcggc ctgcaaatca 679981 tcggaaaaca ctttgatgaa agcactgtat accgcgttgc tcatgcattt gaacaagcaa 680041 cagaccatca taaagcaaaa cctgaactgt aaggggtgaa aagaattgaa ctttgaaacg 680101 gtaatcggac ttgaagtcca cgttgagtta aaaacaaaat caaaaatttt ctcaagctct 680161 ccaacgccat tcggcgcgga ggcgaatacg cagacaagcg ttattgacct cggatatccg 680221 ggcgtcctgc ctgttctgaa caaagaagcc gttgaattcg caatgaaagc cgctatggcg 680281 ctcaactgtg agatcgcaac ggatacgaag tttgaccgca aaaactattt ctatcctgac 680341 aacccgaaag cgtatcagat ttctcaattt gataagccaa tcggcgaaaa cggctggatc 680401 gaaattgaag tcggcggcaa aacaaaacgc atcggcatca cgcgccttca tcttgaagag 680461 gatgccggaa aactgacgca tacgggcgac ggctattctc ttgttgactt caaccgtcaa 680521 ggaacgccgc ttgttgagat cgtatcagag ccggacatcc gcacgccgga agaagcgtac 680581 gcatatcttg aaaagctgaa atccatcatc caatatacag gcgtttctga ctgtaaaatg 680641 gaagaaggct cacttcgctg tgacgccaat atctctcttc gtccgatcgg ccaagaggaa 680701 ttcggcacaa aaacagaatt gaaaaacttg aactcctttg cgtttgttca aaaaggcctt 680761 gagcatgaag aaaaacgcca ggagcaggtt cttctttccg gcggcgtcat ccagcaagaa 680821 actcgccgtt atgatgaagc aacgaagaaa accattctta tgcgtgtcaa agagggatct 680881 gacgactacc gttacttccc agagccagat ctagtcgagc tctacattga tgatgaatgg 680941 aaggaacgcg taaaagcaag cattcctgag cttccggatg agcgccgcaa gcgttatatc 681001 gaagagcttg gcttgcctgc atatgacgca atggttctga cgctgacaaa agaaatggct 681061 gatttcttcg aagaaaccgt tcaaaaaggc gctgaagcta aacaagcgtc taactggctg 681121 atgggtgaag tgtcagctta cctaaacgca gaacaaaaag agcttgccga tgttgccctg 681181 acacctgaag gccttgccgg catgatcaaa ttgattgaaa aaggaaccat ttcttctaag 681241 atcgcgaaga aagtgtttaa agaattgatt gaaaaaggcg gcgacgctga gaagattgtg 681301 aaagagaaag gccttgttca gatttctgac gaaggcgtgc ttctgaagct tgtcactgag 681361 gcgcttgaca acaatcctca atcaatcgaa gactttaaaa acggaaaaga ccgcgcgatc 681421 ggcttcctag tcggacagat tatgaaagcg tccaaaggac aagccaaccc gccgatggtc 681481 aacaaaattc tgcttgaaga aattaaaaaa cgctaataaa aaagcagccc ttagaggctg 681541 ctttttttat ggtcaaattg agataaagac aagatgaggg cccgaagcct ttcaacttct 681601 ttgtcgttgg ttccggccaa attggacagc atgcctttaa taatcggctt gcgcggttta 681661 tcctgagtca attcttcctc gataacatca agtgacacgg tgatatcctc gggcagcgtg 681721 ctgttttctt tcactttctg aatgtcctca agcagctggt cttttcccgc aggcatcggg 681781 ttaaaaatgt cttttgatac aatcggattg agtgcagaac ggctcagccc ctgtacaaga 681841 tcatccagtc tctcaataat aaaggctgag atttcttctg catcgatatt aagctcaccg 681901 ttaaatacca tcacgttcat ataggaatgc acaatgcctc ttgccatgat ggacagatct 681961 gcgacatacc gctcgattcc ttcgccatag gataccagca aggcgttccg gtacagctta 682021 tccgtctcca tggttacttt gtaaaagtat tgcttgattt cttgattttc cggaatgata 682081 ttttcggtaa gcaaaagaac gataaaatct ttatgatcgc gaaaatcctc aaattgagcg 682141 ccaatttgct tttttaacac ttccttaggc ggctttccgg cgagatcttc ttctatattt 682201 ttcattttgt tcatagacat accgatataa tattcacagg cagataacag cagcgcttct 682261 ttcgatttga agtgcaaata aaaagcgccc ttcgaaatgc cgcattcact ggcgatttct 682321 tggatcgtcg tagctgcgaa tccttttttc gcaaataaac gaatgctggt ttttatgatt 682381 ctctcttttt tttcattcat gacgtgcttc cccttaatcc ttgaaaaatt tagtaaaatt 682441 ttctggtata tgagttgacg ttgttgcgtt ataacgttta gtattatata gaatgaccag 682501 tcagtcaata aaaaatgtaa tggaggatat gatgaaccac gttattaatt tcgttctgaa 682561 aaacaaattc gccgtatggc tgatgacgat tattgtaacg gcagccggct tgtatgcggg 682621 tatgaatatg aagcaagagt ctattcctga cgtgaacatg ccttacttga cgatcagcac 682681 gacatatccg ggtgcaacac caagccaagt ggctgatgaa gtgaccaaac cggttgaaca 682741 agccgtacag aacttggacg gtgtcagcgt tgtgacgtcg acgtcctatg aaaacgcatc 682801 gtcggtcatg attgaatatg attatgagaa agatatggac aaagcgaaaa cagaagcagc 682861 tgaagcgtta gaaaacgtca acctgcctga tgacgcgaag gatccggaga tttcacgcta 682921 cagcttgaac tcattcccga ttctgacgct gagcgtgtcc agtgataaag ataatctgca 682981 agagctgacg aaacaagtgg aggacagcct cgtttctaag cttgaaggca tagaaggcgt 683041 tgcgtccgtc caagtatcag gccagcaggt ggaagaggtt gaattctctt tcaaagaaga 683101 caaactgaag gaatacggcc ttgatgaaga tacagtcaag caagtgattc aaggttcaga 683161 tgtgacaact ccgcttggat tgtacacatt cggaaatgaa gaaaaatctg tcgtcgtcag 683221 cggcgatatt gaaacaatta aagatttgaa gaatatgaga atcccgacgg catctgcttc 683281 aagtgcaggc agcagcgcag catctcaagc aggtgcgcag agtgctcaag cagcccaaag 683341 cgcgcaagcg gcagcacagg tgcagcaaag cgcaagcaca gcagtgccga cggtcaagct 683401 ttctgacatt gctacaatta aagatgtgaa aaaagctgaa tccgtttcac gcacaaatgg 683461 caaagacagc atcggcatca acatcgtcaa agcaaacgat gcgaatacgg tagaggttgc 683521 cgacgatgtc aaagctgagc tgaaaaagtt caaagaagac cataaaggct tcaattacag 683581 cgcaactctc gacatggcgg agccgatcac acagtcagtt gacacgatgt taagcaaagc 683641 catcttcggt gctatttttg cgattgtgat tattctctta ttcttaagag atatcaaatc 683701 aacattaatt tctgttgttt caattccatt atcattgctg atcgcactcc ttgtgctgca 683761 gcagcttgat atcacattga atattatgac gctcggcgca atgaccgttg ccatcggacg 683821 tgtagtcgat gactccatcg ttgtgatcga gaacatttac cgccgcatga gactcaaaga 683881 tgagccgctc cgcggaaaag ccttggttcg tgaagcgacg aaggaaatgt ttaaaccgat 683941 catgtcatca acgattgtga caatcgcggt attcctgccg ctcgcacttg taggcggaca 684001 aatcggtgaa ttgtttattc catttgcctt aacgattgtt tttgcgcttg ccgcatccct 684061 agtgatttca atcacgcttg tgccgatgct cgcacacagc ctgttcaaaa aatcattaac 684121 cggtgcgccg attaaagcga aagaacacaa acctggcaga cttgcaaaca tctataaaaa 684181 agtattgaac tgggcgctga gccacaaatg gatcacgtct atcatcgcgg ttctgatgct 684241 ccttggaagc ttgttcctcg taccgttaat cggtgccagc tacctgccgt ccgaggaaga 684301 aaaaacgatg cagctcacat acagcccaga accgggtgaa acgaaaaaag aagccgaaaa 684361 tgaagctgaa aaagcggaaa aaatcctgct tgaccgcaag catgtcgata cggttcagta 684421 ttcattaggc tctggcagcc cgcttgccgg aggagattct aacggtgcgt tattctatat 684481 caaatatgaa agcgacacac ctgactttga taaagaaaaa gataacgttc tgaaggaaat 684541 ccaaaagcaa tctgaccgcg gagaatggaa gtcacaggac ttcagctctt caggcaataa 684601 taacgaatta acatactatg tgtatggcga ttctgaaaac gatattaaag acacggtcaa 684661 agacattgaa aaaatcatga aagatgaaaa ggatctgaaa aacgtaaatt caggcctttc 684721 cagcacatat gatgagtaca catttgtcgc tgaccaagaa aaactaagca agctcggttt 684781 aaccgcgtct caaatttctc aggccttaat gtcacaaaca tcgcaagaac cgctcaccac 684841 tgtgaaaaaa gacggcaaag agcttgatgt gaacattaag acagaaaaag acgagtataa 684901 gagtgtgaaa gatttagaga ataaaaagat cacttccgcg actggccagg aagtcaaaat 684961 cggcgatgtg gcaaaagtga aagaaggatc aacatcagat accgtgtcaa aacgtgacgg 685021 aaaagtctat gcagatgtca caggtgaggt tacctctgac aacgtcacag ccgtatcagc 685081 tgctatccag aagaaaatcg ataagcttga ccaccctgat aacgtatcga ttgacacagg 685141 cggcgtatca gcggatatcg ctgattcctt cacgaagctc ggtttagcga tgctggcagc 685201 aatagcgatc gtttaccttg tgctcgtgat taccttcggc ggagcactag cgccatttgc 685261 gattctgttc tcattgccgt tcacagtcat cggtgccctg gtcggacttt acgtatcagg 685321 tgaaacgatc agtctgaacg ccatgatcgg tatgctcatg ctgatcggta tcgttgtcac 685381 gaatgccatt gtcttaattg accgcgtgat tcataaggaa gcggaaggcc tgtctacgag 685441 agaagcgctc ctggaagccg gctctacacg actccgtccg atcctgatga cagccattgc 685501 gacaatcggc gccttgattc cattagccct cggcttcgaa ggcggaagcc aggtcatttc 685561 aaaaggactc ggcgtaacgg ttatcggcgg tttaatcagt tcaacgcttc tgacgctcct 685621 gatcgtgcca atcgtatatg aagtattggc gaagttccgc aagaaaaaac cgggaacgga 685681 agaagagtaa aaaacaaaaa gcctcagctc tgctgaggct ttcagcttgt tgaaaaaccc 685741 tcgcattcgt tgtcaggtct gcgcgtcggt gctcacgaat tctacattcg ctccgctcca 685801 atgctccccc ttcctagact acaagggttt tcaatcaagc tgaaagaatg ttaaggatga 685861 caaaagctca aaacaagaat cagttttgag cttttgtgcg ttttcacctg taagattatg 685921 tacattttgt tgcgattttt ttaactcata gtataattaa aggttgttag tgtaaaaatg 685981 gatcggatac tcttaagtag gatgatgaga taatgaaacg tgcacgcata atatacaatc 686041 cgacttcagg acgggagatc tttaaaaagc atcttgccca ggtcctgcaa aaatttgaac 686101 aagccggcta tgaaacctcc acccatgcga cgacatgcgc aggagacgct acacacgctg 686161 ccaaggaagc ggcattgcgt gagtttgacc tgatcattgc ggcaggcgga gacggaacga 686221 tcaacgaggt cgtcaacggg cttgcgcctt tagacaatcg tccgacactc ggtgtgattc 686281 ctgtcggcac aacgaacgac ttcgccagag cgctcggaat cccacgcgag gatattttaa 686341 aagcggcaga tacggtcatt aacggcgttg cccgcccgat tgatatcgga caggtcaacg 686401 gccagtattt tatcaatatc gccggcggag gccgtctgac ggagctgacg tacgacgtgc 686461 caagcaaact gaaaacaatg ctcggccagc ttgcttatta tttaaaagga atggaaatgc 686521 tgccttcact tcgtccgaca gaagtcgaga ttgaatatga cggcaagctg tttcaaggtg 686581 aaatcatgct gtttttggtc acgctgacaa actccgtcgg cgggttcgaa aagctcgcgc 686641 cggattccag cctgaatgac ggcatgtttg atttgatgat actaaagaaa gcaaaccttg 686701 ctgaatttat cagggtcgcc acgatggcgc ttcgcggaga acacatcaac gaccagcaca 686761 ttatttatac aaaagcgaac cgcgtgaaag tcaatgtatc agaaaagatg cagctgaacc 686821 tggacggcga gtacggcggc atgctgccgg gcgaattcgt gaatctgtac cggcacattc 686881 acgtcgtcat gccgaaggag aaagcggaac agttggatga ctaaaacttg gcttggtaag 686941 ccaagctcag aatgttgaca aaatcctaaa acagttttcg ttttaggatt ttgtcatctt 687001 ttcagcgtga ttgaaaacct ttgaagtcta ggaagggcga gcatcggagc acagcgaatg 687061 ttgaattcgt gagcaccgaa gcacaggcct gacaacgaat gcgaaggttt gcctacacgc 687121 tgaaacttgg cttgaatagg ccaagttttt ctttcgctta aaactagagg tgattataga 687181 tgaaaatgaa acccccagta gaaaaaaatg aatactacga tgtgacattt gaggatttga 687241 cacatgaagg agcgggcgtc gcaaaggtcc aaggcttccc gatctttgtg ccgaatgccc 687301 tacccgagga aaaagcccaa atcaaagtga cacgcgtcaa aaaagggttc gccttcggcc 687361 gcctgattga gctgaaggaa gaaagcccgc atagaacgga cgccccatgc ccgatttaca 687421 aacaatgcgg aggctgccag cttcagcaca tgacctacga aggccagctc ctgtttaaac 687481 agaaacaagt caaagacgtc ttagaacgca tcggcaagct ggacctttca aaagtcaccg 687541 tgcacccgac actcggcatg gaagacccgt ggaactacag aaacaaagca caggtgccgg 687601 taggagaacg ggaaggcgga ctcgtcgcgg gattctatca gcaaagaagc catgacatca 687661 tcgacatgag cgcctgcctg atccagcaat ccaaaaacga cgaagccgtt caagctgtca 687721 aagacatttg cgcaaactac ggtgtcaaag cctacaacga agaacgccac aaaggctggc 687781 tccgccacat catggtcaga tacggcgttg ttacgggcga aatgatgatc gtcttcatca 687841 caagaacaag cgacttcccg cacaaagcga agatcatcga agacatcaca gcgcaattcc 687901 cgcacgtcaa atccatcgtg caaaacatca acccaaacaa aacaaacgtc atttttggca 687961 acgaaacaaa cgtcatctgg ggcgaagaat acatctacga cctcatcgga gacgtcaaat 688021 tcgccatctc cgccagatcg ttttatcagg tcaacccaga gcaaacaaaa gtgctctacg 688081 acaaagcgct tgagtacgct gagcttcaag gggaagaaac cgtcatcgac gcttactgcg 688141 gcatcggaac gatttctctc ttcctggcaa agcaggcgaa aaaagtgtac ggtgtagaga 688201 ttgtgccgga agcaattgag gacgcgaagc gaaacgccga attaaacggc aacacaaacg 688261 cagagtttgc tgttggagaa gcggaaaccg tgattccaaa gtggtacgaa gaaggcatta 688321 cagctgatac gctggtcgtc gacccgccaa gaaaaggctg cgacgaagcc ctcctgcgga 688381 caattgtgga gatgaagccg aagcgggtag tgtatgtgtc ctgtaatcct ggcacgcttg 688441 cgagagattt gcgggtgctt gaggatggcg ggtacgtgac gcgcgaagtg cagcctgtgg 688501 atatgtttcc gcatacgaat catgtggagt gctgtgtgtt gataaaatta aaagaataaa 688561 tagtcaaaaa tctatgctga tggaactgtt ggttctctaa aacgataatt gatttcaatg 688621 gttccatttg catgtacttc tatttcatct actaacaaat gaagcatttc gggggtaagt 688681 gtaccttcct tcatgaattt atctaagctc tttttaaaat caattatttc tttttcaatc 688741 ttttgaaatt ctaggtcctt agatagttgg tgaagggtag tttcaaaatt tgaaatatct 688801 tcattggtga tatttatggc taattggtaa tcttctttag atataacacc attagcaaga 688861 gagataacta aattggattt atctctcttt ttatcgttta atttttcatt aatttcgatt 688921 atcttagatt cgattttttc tttgtacttt aacgcttttt cacttaattc tttaaaataa 688981 ttttccttac tgaatttcaa atatatctta tttaggttgg ttattacttt atcagttaaa 689041 tctatttcac ttacgtaatg atcactacat gcttttaaac catgtttatt ataacttcca 689101 caaacataac cttttcgatt ctttttaaaa tgcattgacc tcctgcaatc tttgcaaacc 689161 gcagtatttg taaagagatg tacttcagct tgaggtctcc ttctttttct agttattaaa 689221 atctcttgta caataagaaa gtcttctaaa ggtatgattg gttcgtggct tttttcaata 689281 attatttggt tttctaggtt aactgacctt cttcttttac tggtaacact cggtctatat 689341 tctctacatt gttgtagtgt cccagtatag tgaggatttt cgagaatttt tcttattgaa 689401 gatccgtgcc atttgtcagt agcgttcttt ttgcgggcaa gctgcgaggg actagtgacc 689461 ccttcgttat acaatcccct tgctattgca tcaaagcctt ttccagcaat atattctgaa 689521 aagattctaa tatttactat tttctctgcg tttgctgaat ttgagagaga tatgattgta 689581 gaacgaactc aagaaggtaa aatgttggcc aagcagaatc cggatttccg agaaggaaga 689641 cccaaaaagt tcacaaagca gcaaatcaat catgcattaa cattactaga aaatcattcg 689701 tataaacaag ttgaagatat gactgggata tcagtttcta cacttgtaag agctaaaaag 689761 aagaaagctg ctgaagctat aaatggataa atattgtgaa ttaattattc aatatcttga 689821 gaaattttta taaaagtaat caaaagttta atgggggaaa cgaaatggcg ctcattgatt 689881 tagaagataa aattgctgaa atagtgaatc gagaagatca ttcagatttc ttgtatgaat 689941 tactcggtgt atatgatgtt ccacgagcta caattacgcg cttgaaaaaa ggaaatcaaa 690001 accttacaaa acgggttggt gaagtacact taaagaataa ggtgtggttt aaggaggcta 690061 agaaaggaaa gctctttgac gcccttattg atatagaaca acaagttgaa tatctttcag 690121 ctaagccacg atatttatta gttactgact atgatggagt attagcgaaa gatacaaaaa 690181 cattagaggc tcttgatgtt aaatttgaag aacttcctca gtatttcgat ttcttccttg 690241 cttggaaagg tattgagaaa gtagagtttg aaaaggaaaa ccccgctgat attaaagcag 690301 ccgaacgttt tgcacggata tatgatgtac ttcgtaaaga aaacaatatt attgagacta 690361 atagagggtt agatttattt cttattcgtt tactgttttg ttttttcgca gaagatactg 690421 acatcttcaa acgaaatagt tttacgaatt taattaagac tttgactgaa gaagatggtt 690481 caaatctaaa taaattattt gctgatttat ttatcgtgtt agataaaaat gaacgagacg 690541 atgttccatc ttatttaaaa gagtttccgt atgtaaatgg ccagttgttt actgaaccac 690601 atacagagtt ggaattttct gccaaatcca gaaagttaat tattgagtgc ggtgaattat 690661 taaactgggc taaaatcaat cctgatatct ttggttcaat gattcaagct gttgcttctg 690721 aagaaagccg tagttattta ggtatgcact acacaagtgt ccccaatata atgaaggtta 690781 ttaaaccgct tttcctagat aaacttaatc agtctttttt agatgcatac gatgattata 690841 caaaacttga aaatcttcta acacgaatcg gcaaaattaa attctttgat cctgcatgtg 690901 gttcagggaa ctttttgatt attacctaca aagaattacg gcgtatggaa atcaatatta 690961 taaaacgact tcaagaactc ttgggagagt atctttatgt accttcagta actttatctc 691021 aattttacgg aatagagatt gaagattttg cacatgacgt tgcaaaatta tcactttgga 691081 ttgctgaaca tcaaatgaat gaagaattaa aaaatgaagt tcataatgca gtacgcccaa 691141 cgttaccact tcatacagca ggggatattc gttgtgcaaa tgctattagg gttgagtgga 691201 ctgaggtttg tcccgcacaa ggatctgaag aagtatatgt ttttggtaat ccaccgtatc 691261 ttggttcaaa aaaacaaaac aaagaacata aatctgatat gttatcaatt tttggaaaag 691321 tcaagaatgg taaaatgctt gattatattt ctgcttggtt ttactttggt gctaaatacg 691381 cttcaactac aaatgcaaaa gttgcctttg tatcaacaaa ttcagttact caaggggaac 691441 aggtttctat cttatggaat gagttattca agtttggaat tcaaatcaat tttgcctata 691501 aatcttttaa atgggcgaat aatgctaaaa ataatgctgc ggtaattgtt gtgattgtag 691561 gttttggccc gttagatacc aaagtaaaca agtatttatt tgttgatgaa acgaaaaagc 691621 tagtttctaa cattagtccc tatttaactg atggtgaaaa tattcttgtt tcttctagga 691681 cgaagccaat ttcagactta cccaaactgc attttgggaa catgcctaat gatggcggag 691741 gattactctt taccattacg gaatatacag acgcaatcaa taagtatcct gaattagttc 691801 cctattttaa aaagtttata ggttcagtag agtttattaa tggtggttta cggtattgtt 691861 tatggcttaa tgaagcaaaa tatgaaaaaa taaagtctaa tcctctaata caagaaagaa 691921 tctcaatttc aaaaaatcac agggaaaaat caacagataa aggaacgaat aaacttgcat 691981 taactccgtg gaagtttaga gatactcatg aaacaactaa ttattccatt gttgttccat 692041 ctgtgtcttc tgaaaataga ttttatattc caatgggatt agcaggtgca gatacaattt 692101 tgtcaaatct aatttatgta atttacgatg cagaaattta ccttctaggc attttgatgt 692161 cacggatgca tatgacttgg gtaaaagctg tagccggaag attaaaaact gactataggt 692221 actctgcagg tttatgttat aacactttcc ctattcctga attatcaaca agaaggaaga 692281 atgaaattga agaagcaatt cttgaaattc ttgatcttcg tgaagagcag ggtggtacat 692341 tagcagagct ttataaccct tcaacaatgc caattgaatt aaaagtagca catgaaaagt 692401 tggatggaat tgtagaaaga gcgtatcgtc aaaaacaatt tgaatctgat gaagaacgct 692461 tagaagtatt gcttaaattg tatcaagaaa tgacagaacg gtaggtgtaa ggtgtatgga 692521 aaatataatt gaaattaatt ataaccaaac tggtaaaagt aagaaaacaa atgaatacgg 692581 tatgcgtgaa atgcaggcaa gagcttttga aaaacgtaac tcacaatatc tcttagttaa 692641 agcaccgcca gcttctggga aatctagagc tttaatgttt atcggtttgg ataagctcat 692701 aaatcaaggt ttgaggaaag tgattgttgc tgtacctgaa cgctctatag gttcttcatt 692761 taaaaatacg gatttaaaaa gttatggttt ctttgaaaat tggaaagttg atcctagaaa 692821 taatttaact gttggcggag ataactctaa ggttaaatct tttgttcgtt ttatggaatc 692881 ggacgatcag gtgttaatat gtacgcactc tactttgcga tttgcgtttg aaaaaattga 692941 tgataaagca tttgataatt gtttacttgc aatagatgaa tttcaccatg tatcggcaga 693001 tgtcaattct cgattaggtg aattgttaag aagtattatt cataattcat cagcacatat 693061 tgtagcgatg actgggtcgt atttccgtgg agattctgta ccaattttat taccagaaga 693121 tgaggaatta tttgacaagg taacttattc ctattatgaa caacttgatg gatatgaata 693181 tctaaaggga tttggtatag gatatcactt ctatcaaggc cagtacacat cagctattaa 693241 tgaagtattg gatacaaata agaaaacaat cgttcatatt ccaaatgtaa actcagggga 693301 atcgacaaag gataagtacg atgaagttgg taagatactt gatatgattg gtgaagttga 693361 atatcaagat gatgatactg gaattattta tgttaagcga cattctgacg gtaaaacatt 693421 gaaaattgca gatttagtag atgaccaagt tggaagagaa aatgtcgttg cgtatttgcg 693481 taatattgaa gccctagacg atttagatat aattattgct cttggtatgg cgaaagaggg 693541 ctttgactgg ccgttttgtg aacatacttt gacagttggt tatcgtggct cacttacaga 693601 aatagtacaa ataattgggc gctgtacacg tgatagttac aataaaacct atgctcaatt 693661 taccaaccta atcgcaatgc ctgatgcaaa ggatgaagta gtgacttata cagtgaatac 693721 aatgcttaaa gctatttctg cctcactttt gatggagcag gtccttacac ctgactttaa 693781 atttaaacgt agaagaaatg aaagtgaaaa atcttctact acaggagaat tattcgttaa 693841 gggattgaaa gaaccatcaa cagaaaatgt caaaaagatt attgaaaatg atattaatga 693901 tttaaaagca aaaatcatgc aagattcaca agtccaaaaa acatttagtg gagaagtaga 693961 tcccaaagta ttgaacaaag tgttgattcc gaaagttatt caaaaagtat atccaaattt 694021 atcagatgag gaaattgagg aagttagaca gcacgttgtt ctagatacag ttatgaaagg 694081 tgctaagtct gaagttgtag gaagtaaaga atttataaga atggcagata agtttataaa 694141 cattgaggat ttagatatca atctgattga ttccatcaat ccgttccaaa aagcatttga 694201 ggttctatcg aaagaattga actcaccagt gctaaaactg attcaggaaa ctattgatgc 694261 aaaacgtatt aattttgatg aagatgaact agtattcata tggccaaagg tttaggaatt 694321 ttatcgttca actggtagaa gacctgattc aaaatctgaa gacccacttg aaaggcgtat 694381 gggtgaagct gtattataca tgcaagagct taggaggaaa cgtgaaaatg gcaagtaata 694441 gataccattc tattaatgaa atcatggaaa gtcagctgtt ttaccaaatc acaacaccac 694501 ctaagaaaac acaaaaagcc cagtatgatc ctgaagttga aaagtttttg gagattattg 694561 aattcgtcaa agaaaatggg cgagaacccc aaaaagtccc tactgattta actgaaagaa 694621 gtttagcaag tcgattaatt gggattcgga aagatcctga tcgtatggaa tatttgaaag 694681 agtatgatga aattggatta cttgaagtaa gatcgaagga actaacaatt cctaaaattt 694741 cttcaattga tgatattcta aaaagtggct tatctgcatt attaggtgat aatttaaata 694801 atgatataac taggtcaatt tttgatacaa gttcacttca aaaggttacg acaatgcctg 694861 aatacgttgc aaagcgtaaa aaaataaaag attttggaaa gtttgaagag ctattcaaga 694921 agtgccacaa ggaaattaca gagggtaaac gaaaaatttt aactttcaaa aatgaacaag 694981 acatacagtc aaatagtttt tatatattaa aaggagttct tctttatgtt gaagatgtgg 695041 gagaacgtaa aaaagcaaag ggaaaaacca atgctagact tcgatgtata tttgaaaatg 695101 gaacggaatc agatatgtta ctacgttcct tatcagcgga gttatataaa catggtagac 695161 gtgtgaccga caatgaagat acattgttgg ataatgttag agaagatgat gtttcgactg 695221 gctttattta cgtactaaaa tctttgagta cagatccgca aattagttcc attaagaatt 695281 tatataagat cggttttaca actggttcag tagaaaatag aatcaggaat gcagaaaatc 695341 aatcaactta tctttatgct ccagtagaaa ttgtaaccac atatcaagtg ttcaatatga 695401 atgctagcaa atttgagacg gcaatccatc atgcgctagc aaataataat ttggatgttt 695461 ctattttggg ggcaaatgga aagatgttag ttcctaaaga gtggttcgtt gtcacacttg 695521 aagatttaca agctgtaata gatgagattg tgatgatggt tcatctttat gactaaatta 695581 gtatattagg attttagtat taataataat tttatagtag actatgaaaa aatttgatgc 695641 cataacaata acttgttccg ctttggagtt tgtcacaatt gtagaattat gtgttgcgag 695701 tattaatagg aaggggttga gcgaccgcaa aaaaaatttt cggtgctgtc cgcaaaaggg 695761 agtttgggtg ttttgcgtta tatttggttg tgtgaaggtt agcggaaact caattcgtga 695821 agttaggatt gcggttatta cgactgagta gtttcgtcat actcttttag cagtttttct 695881 gtcttatgca tttctttgag catcggattc atgtagtcgt tagctgattc tagatatgct 695941 ctcgtcagag tgtctagttt atttctaact ttagagaggt cttcttcgaa ttttccatcc 696001 gatgattgaa ggataaattc ttttgcctct tcatatcttt ttaatatgtt tttcaccatt 696061 ggagttggat tcttttgatt tattgttttt attacagtga ttgttaaatt tatttgtttt 696121 attaattctt ttcttactgt caaggtgatg ctccttttaa atctctattc tatttgagag 696181 ttgctatatc tgtttaatgg tttgatagac tactcatctt tataatttag agcaattttt 696241 acaacttgtt ccgctgtgta atcttcattg ctccagaaaa ttaaatcact tggtgccgga 696301 taaggaacat ttttctctaa taaatcgaga tattcactga ctttctcatc atctaatgtt 696361 gggttcatta attcctttac aagaaagatc aactcttctt ttgtcagttt atccattgtt 696421 tgccctccaa tagattgtat ctccattgat tttacaaatg actttatttc ttctgataat 696481 gttataggtt gtttgcataa tgatagataa ttgtcttgag aaaagttagt ctcattatag 696541 agtttattaa ttgtatttat aacaatatat tcatatggaa aacctctaaa atatctttat 696601 tttagattgg tttataaaaa atagctcagc agagtagggc tgagccattt tttaattata 696661 gaccgaggta actaattaca aattctttat catcctcatc ttcaggcaaa ataccaaggt 696721 ttttatattc ccatattgcg attctttcat atccatctaa ttctgaggct aaaatatcat 696781 cataattata atctaattgg aattctccgc tacgatccaa tgttagtgta aggttagtcc 696841 aaacatcatc gttattattt ctgtgttcag ttcttaattc ttcaaaaagt tctcttagtt 696901 ctcttaacaa cgtcttgaaa atatccttgc ttacgttgta atggctaggt atatcttgtg 696961 aataaataat ttgattattt tctggtgttc tgaaatgaaa aagaaccatt gtggaatcat 697021 ctaatacttc tgcataaaga tatatctttg tccattcacc aggtatgatg tcattgagtt 697081 tttctccaat aagttgatac aaatcttgca tcttcctagt ttccattctt ctaaccccca 697141 ggctgatttt taatagagac gcttatttct tttctgctcc caattttgta ggttacatcg 697201 aaatatgatg gtctaagtga atccccagaa tagactggtt ctatttgaac tgctactttt 697261 ttaggtggtt ttttgcttag ggcttttgcc cactcctgct ccatctcata ccatttccca 697321 ccgctcctat taatctgaga attcatcggc acgatattgt caaactggcc tgagcctttg 697381 aattgggtgg cgattaaatg gccgccgtca tcgtcaggct ttcggtcctg gggctttcca 697441 gcattcgttt gtgcatattg gtttcgtttc gcttctccca gctgcaagtc tgctttgaca 697501 cttgtaattc taccatagtt gtcagtcgtg tacgtgtagc cttcttttgt tttgtagatg 697561 atattaggct tcagcacttt ctttctgctc catcttgcga aatgctcgcc gtatttgacg 697621 gttaccggcg gtacatgtgg cgctggagtt cgtcttccgc ttgatgacgt tccgtatggt 697681 ttcggcagga tgaccttggc gaatttttgc agtccttctt taagcgtgac cccgttgact 697741 gcgttgtaag gaacgcctgc cggcactaaa tcatgacggg gatgatacgg gagaatatcc 697801 gcaagtgtga gatctccgat ttgatttaac ttggttttga cgtgtttttt tgatacttca 697861 atgcctgtgt ttactttttg tttgatgtga tcaacggttt gttttgagac tgttatggct 697921 ttttgggctg ttgctgattt gcttgctgct gttttgactt tggtcgtcac tttggcggct 697981 gtgccagttt ttgagacggc tcctacgcct tttgtgccga caattgatgt gacaacagtg 698041 ccaaccgcat atgacaccca tcttgctctt gagtaggtgt caccattcac catgtctttt 698101 tgatacgatt cttcgattgc cgctgaaatg gcttcatacg ttttgatcgg gtgagccatc 698161 gctccggtaa tcgcttcaac ggttcctccc ggatctgtga ccatatccca caggcctacg 698221 accgcgtctt tcccggaatc ataaaggccg acggcaaccc ctttgaagcc tgcttcaagc 698281 tcacgcgtgt tttcaatttg ggtgaagtat ctctgttgtt cagctgtcag attttcatag 698341 ccgatcgttt ttgccatttc gtagaattca tcggcatctg cataatcgta gtttttcagt 698401 ctttctttca gtttctcaat ctcgcgttcc ttcgcttcct ctttcttaat cttcaagtaa 698461 gcctcagtcc gcttttcaat gtcgcctttt ttcttatgta tgtcactctc acggtacgcc 698521 ttggcgttgt agtggatggg tgtggcgttt ttgcctttac ccgttgcttc ttggagcttt 698581 tggaagtcgg atttgatgaa ttgttcgttt ggttcagaca gggcgtattc tgttttcagg 698641 tcttcgtcca aggcgtccaa tttttccagt gtttttttgc gtttgtcgtt ggcatcggcc 698701 agctcgtctt tgaaggtttc tgttgaaaac aggtcgagcg ggaggatgtc gtcgatatcg 698761 tttaggatgt ctttcatcgc ttttttctgt tcggacatga tggatttaga ttttttattg 698821 gcatttgcca gttcgtgctc caggaaggat tcttcgatgt atgcgtctga gaggcctttg 698881 tcttcggcgg ctccggcgat gctgttgaaa aatgcgattt tcatgtcgat gtagtcgatc 698941 cactggtcgg cgacgccgac gtggtcgtga tagaatgcct tgatgttgct ggcgcctttt 699001 cctgagaatt cactgtcact gagatcagcg actcctttta acgcttttct caagttgacc 699061 atttgcgttc ttagttcttt gtactctttt gcacggtctg tcgcttccga aagcagtgtt 699121 ttcgcttcaa atactttcat gaccatttcc cttcttttgt tcgctcaata tcaaaatttt 699181 accacgggtc gggataaggt gggggtgaga acgtgttttg gtggaaaaat gagtcatttg 699241 gcatgtgtct ttattcgtgg agggattgga ggaaacatgg tcgaaatgat attgattgct 699301 acacattttt tggaagtttg tattctatat tgttttttaa ggagcatgtt gatgacgaaa 699361 aaacggatta catttggttt attagtttta atggtatgtg tcatcctgtt tgttctgtat 699421 gttcagttac gcaataaaga tagtattcct gtccaatctt ccgccattca ccccgaagaa 699481 gaccgcatct tttttattta ctccaatcct ttcataaaag aaagcgtgct gctttcaacc 699541 tctacaggcg aacggtttaa caggcgtacg tttaaggtgg cggatgtgcc ttatattcaa 699601 acgaaatctt atgcatcaac agaccttgta ttattggcgg aacacgagcc tttttactac 699661 acgctggaga aggatgtgat caaagagcat ccgctgtcag atccatttgc gttttggtat 699721 gaggggaagg atgtcactat tgaggcctat aatgttgata cgacgggaaa tgagatccac 699781 ataaacgaca gaaaaacgaa aaaggaatat acccttacct tgcctccgct tgtcacaatg 699841 ggggccagtg atgagaactt tatttatatc attcaaagca tgtctattta cgtgattgac 699901 agaaaaacag aggaaatgat tgagaccctg agcttagcct catacgctga tcaattcgca 699961 gactcggagg aatttatcgt cgcgagctcg gatcataaat tgactgtgat tgaaaaaggg 700021 acatggaaga cgacatatat tgcgtatcct gaagatcttg aatatgcaga tactgtgtac 700081 tatgacaaag aaagcggcag tttttacgtg gcgtacgagg acaaagaggg tggagcgaac 700141 ttgctggaat atggggagga tttttctatt cacacataca gcttgaaatt cccttatatg 700201 gaggcgaagt ttaaggggaa tctattgtat atagttgccc aggaagagca taaaaagggc 700261 atcggcggat acgtgggtgt gtttgatatc cattctaagg agatgcttta tcagtttgat 700321 ttgcctgagg aacaggtgaa ggttcaggat tttgttgtgg ttgacaataa gtgaatacta 700381 tatgaaatag aatgacaaag acccttgcat aaagggttct tttttatgaa aaaaacaaat 700441 tgacaggatg aaaaaacaat ttcttccttc tatattgttt tcaaaatttg ggattgatag 700501 aatatgacat atctcataga gaaggaggga agccgttgag tcaagccata ccgtcttcgc 700561 gtgttggtgt taagattaat gaatggtata aaatgattcg ccagttcagt gttccggatg 700621 ctgagattct gaaagcggag gttgagcagg acattcagca gatggaagaa gatcaggatt 700681 tactgatcta ttattctctg atgtgttttc ggcaccagct gatgcttgat tatttggagc 700741 cgggaaaaac atacgggaat cgccctacag tgacagagct tcttgaaacg atcgagaccc 700801 ctcagaaaaa actcacaggt cttttgaaat actactcttt gtttttccgc ggcatgtatg 700861 aatttgacca aaaagaatat gtggaagcga tcggatatta tcgcgaggcg gagaaagaac 700921 tgccgtttgt gtcagatgat attgagaaag cggaattcca ttttaaagtg gcagaagcgt 700981 attatcacat gaagcaaacc catgtgtcga tgtatcatat tcttcaagcc ttggacattt 701041 atcaaaacca tcctctatac agcattagaa cgatacaaag cttgtttgtg atcgccggca 701101 actatgatga tttcaaacat tatgataaag cgctcccgca tttagaggcg gcgctggaat 701161 tggcaatgga cattcaaaat gacaggttta tcgccatttc tctattgaac attgcaaaca 701221 gctatgacag atcaggagac gatcagatgg ctgtagaaca tttccaaaaa gcggcgaaag 701281 taagcagaga gaaagtgcct gatctgcttc cgaaagtctt gtttggatta agctggacat 701341 tatgtaaagc gggccaaaca cagaaggcgt ttcagttcat agaggaagga ttagaccata 701401 tcacagcacg ttctcacaaa ttttataaag aattgtttct gttcttgcag gccgtgtaca 701461 aggagactgt tgatgaacga aaaattcatg atcttttaag ctatttcgaa aaaaagaacc 701521 tgcacgctta cattgaagca tgtgcccgga gtgctgccgc tgtttttgaa agcagctgtc 701581 actttgaaca agcagctgcg ttttatcgga aagtgctgaa agcccaagaa gatattctaa 701641 aaggagagtg tttatatgcc tattaagaaa aaagtgatga tgtgtctggc tgttactcta 701701 gttttcggaa gcatgtcgtt tccaaccctg acaaactccg gtggatttaa ggaatcgaca 701761 gatcgaaata cgacgtatat cgatcattcc ccttacaaac ttagtgatca gaagaaagcc 701821 cttagctagg gctttttctt gctttacgga agacgttcca ttttccacat cgcggcattc 701881 cttctatttc taacgcaaga cactcgaaac aaccaaacca tttgaggtat aatggataaa 701941 gtgaataaca gtatttagat tgatatatat gaaagagagt ggaacatcat gggccgtaag 702001 tggaacaata ttaaagagaa gaaggcgtct aaggacgcaa atacgagtcg gatttatgcg 702061 aagtttggcc gtgagattta tgtggcggcg aaacagggcg agcctgatcc ggaatccaac 702121 caggcgctga aggttgtgct tgaacgtgcg aagacttaca gcgtgccgaa aaacatcatt 702181 gaacgtgcga tcgagaaggc gaagggcgga gcggaagaga attacgatga gcttcgttat 702241 gagggcttcg ggccgaacgg atcaatgatt atcgttgatg cgctgacgaa taatgtaaac 702301 cgtacggcgc cggaagtgcg tgcggcgttc gggaaaaacg gcggaaacat gggtgtgagc 702361 ggatctgttg cttacatgtt tgacgcgacg gctgtaatcg gtgtggaagg caaaacggct 702421 gacgaagcgc ttgaaatcct gatggaagcg gatgttgatg tacgtgacat tttagaagag 702481 gatgacagcg cgatcgtgta tgccgagcct gatcaattcc atgcggtgca agaggcgttt 702541 aaaaacgcgg gtgtcgagga atttacagta gcggagctga caatgcttgc gcaaagtgaa 702601 gtaacgcttc cggatgatgc aaaggaacag tttgaaaaat tgattgatgc attagaagat 702661 ttggaagatg ttcagcaggt atatcataac gttgatttag gtgagtaagg agtgagcagg 702721 ctgttatggc ctgctttttt tgtcccggaa attgttttag ctgtatgtag gcggccgcct 702781 atacgatcta taagatattc tcatactctg gactgtaacc tatgtgaagg agagagtaaa 702841 tatgactgat acaagacata tgtatggcgg acctggtttt ggtcattatc agggctttgg 702901 tattggccac ccgggctatg gcatgcaaag cacaggctat ccgggctatg gcatgtatgg 702961 aggccacccg ggctatggca tgcaaggcta cccagatcac ggcatacatg gaggagtcgg 703021 cggctatccg ggatatggtg ggtacggcgg ttacccaagc ggcggctatg gaggctctcc 703081 gggaactgga agctatccga gcatgcacca tgaaaatgat ggccatcacc actattatca 703141 ccatcatcat gatggaaaag ataatcttca tcaccatcat caccatgttg gaaaggataa 703201 tcatcaccac catcatgatg gtcattatgg ccaccatcat caccatatgg gccactgggg 703261 aaaagacggt tataaataaa gaagatgatg ataaaaagag gacactcttg cagatcaaga 703321 gtgttttttt agcttttttc ttgactgttc agtctggaaa atggtaacat ttgtttcagg 703381 aggtgatcat tttttgggga ggaataaaga atttgatacg gcgcttgttc ttcacagggc 703441 gatagaggtt tttggagagt atggctacga aggaacgtct cttcaggatc tgctctctca 703501 tttaggcatt gcgcgccaaa gtttgtatga tacgtatgga acgaagcgtg atttgttttt 703561 gtccgctgtg aaatcgtatc ttgaagggaa aaacgctgcc gttatggaaa ggcttgaagc 703621 gccaggatct gtaaaggaag ccattcgtga tatttttcag gagggtgtca atgccctgag 703681 ggatccggaa cgggcgaagg cgtgctacat tattaacagc gcgattgaac agatcccgca 703741 tgaccctgag cttgcccggt attttgaaag acaatccaag cagcttgagg acgcttttta 703801 tcacgggctt ttaagagcga aggatcaagg agaattgaat ggcgaagata ctgatatatc 703861 tgcgcttgct cggtacctga atcagagcag gctgtcactg acatttattg caaaagtgac 703921 ggcagatatg gatcggcttc aggaccatgt tgacgtgagt ttatcagtgc ttgattaaca 703981 tgtggtaaag gattctttgc ccatgtatgt actttttgga ctgaatagtc tagaaataaa 704041 aatgaggtga tgatgaatgt tgatgaatga gtttgaaaaa gcatgtgaaa cattgagaaa 704101 gtttatggct tatatgcttg agaaggacat gaagagctgg acggagcttt gggatgagaa 704161 tgctgtattt gagtttcctt atgcgccgga gggatcacca aaaagaatag aaggaaaagc 704221 ggccatttac gattatatta aagattatcc taagcagatt catctttctt catttaccgc 704281 tccgacagtg taccgttcag cagactcgaa tacggtgatt gcggagtttc aatgtgacgg 704341 ccatgtgatt gagactggac tgccttatcg ccaaagctat atcagtgtca tcgaaacgag 704401 agacggccgc attgtgcgtt atagggatta ttggaatccg cttgttgtaa aagaggcctt 704461 tggaggatca tttttgcaaa cagaggagag tgggaaatga tgaaacagaa tccgatttta 704521 atcacgggcg ggaccggcac agtcggcagc cgaatcgcca gccgtttaat aaagctggga 704581 tacagagtgc gtattgcaag ccggaaaaag ggcgcgcttg ctgatgctga gtatgtgtat 704641 tttaattgga agtacgcctc cagttttacg cctgctctgg aacaggtaaa acagatctat 704701 cttgttgctc cggtcggtgt atttgatccg gctccctatg tgcttccctt tttaaaggaa 704761 gcaaagcgtc tcggcgcaaa gcgggtagtg atgcaaagtg cgtctgttgt ctccgagaac 704821 ggtcccgtgt ttggcgcgct tcaccaggca gtgcgcgagt ttccagaatg gacggtgctg 704881 cggccctcat actttatgca aaatttcatc aatgtccagc accgcatgtc tattcaaacg 704941 gaggggcgca tcacaacggc ttcgggtgaa ggaaaacttg ggtttattga cgctgatgac 705001 atcgcagaaa cagccgtcag ggctttgatt gatgatgttc ctcatcaaac acatcatatt 705061 ctgacaggtc ccgaggcgct gagctatgcc gaagcggcgg agatcattgg agctgcggcg 705121 ggacgccggg tggagcatgt cagcatttct cgttccgagc tgcagcataa aatggaggca 705181 ggaggtttgc ccgcggatta tgcccatttt atggcgaagc ttgatgaggc aattagccat 705241 ggtgcggaac atcgggtaac ggatacagtg aagcgtgtga cgggaaaaga acctcgttcg 705301 ctgtcagagt ttgcggctgc tcatgctgca tattggacct cattttggac tgaatagtct 705361 agaaagacct tcggcgcttc cgaaggtctt cttattgaaa aagctaagtc gtgttttagt 705421 cataatcatg cctcctgcct catacctatt aaggtcattg tttttgagaa aggaggagcc 705481 ggaatgaagg atatgcagcc gtttacgcct gtcaaatcat atacgccctt tcacagccgt 705541 tttgatccct gtccgcccat agggaagaaa tattacagaa cgccccctaa cctttatatg 705601 acctttcagc ctgagcacat ggagcagttt tcgccgatgg aggctttgag gaaaggcacc 705661 ctttggaagg atctctatga tttttatgaa aacccttatc gagggggaga cgcacatggc 705721 aaaaaaggtt gacgccgaat attatcgtca gctagagcaa atacaggctg ctgattttgt 705781 gcttgttgag ctgagtcttt atttaaatac acatcctcat gatgaagatg cgttgaagca 705841 attcaatcaa tattccggct attcaaggca cttaaaaaga cagttcgaat cctcttacgg 705901 accgcttctg cagttcggca acagccccgc gggcaaggat tgggattggg gaaaagggcc 705961 atggccgtgg caagtataag gaggaatgcc tgaatgtggg tgtatgaaaa gaagctgcaa 706021 taccctgtca aggtcagtac gtgcaacccg acgctggcga agtatttgat tgagcagtat 706081 ggcggagcgg acggcgagct ggccgcggct ctccggtatt tgaaccagcg ttatacgatt 706141 cctgataagg tcatcggcct tttaacagat atcggcacgg aggagtttgc ccatttggaa 706201 atgattgcga ccatggtcta taagttaacg aaagacgcca caccggagca gctgcgtgaa 706261 gctgggcttg gcgatcatta cgtcaatcac gacagcgcgc ttttttatca taatgcggcg 706321 ggcgtgccgt ttaccgcgag ctatatccaa gcgaagggcg atccgattgc cgatttatac 706381 gaagatattg ccgcagaaga aaaggcgcgg gcgacgtatc aatggctgat tgatatttcg 706441 gatgatcctg atttaaacga ttccctgcgt tttttgcgtg agcgtgaaat cgtacactct 706501 atgcgcttca gagaagcggt tgaaatttta aaagaagaac gggataaaaa gaagattttc 706561 taataggcag attggcctct ctttcataca cccttttaca tacagagaaa atggtctgtt 706621 tttgcagttt ggtctgcatt ataatcaagg tgtgtgtgca agcttacttt ttgattggga 706681 ggcctttatg acagctttta agattgagaa cgaaacgatt gcagatggat tttacgcgtg 706741 tccggccgtc tatgaggatg cagaatcgat taccgggttg ctcgtccgaa cagctgaatg 706801 gctccgggat cggggttcta accaatggag cggacttctc aaagggcaag atatacatga 706861 tatcacgggg tcaattgaaa agggacatgt gtttgtgttt aaaaaagatg aagagcttgc 706921 ggctgtcgtg atgctgctgc ctgcaccgag cgagtgggac cggacgcttt ggggagacga 706981 tgggcatgag gagtccattt atttacaccg cctcgcagta agccgccggt ttgcgggaca 707041 ggggcttgga gcccgcgtcc ttcagtgggc ggagacgggc atacactttc cggaaaaaac 707101 gcggatccgg cttgactgtg tcgctgatag tgacgccctg cattcctttt atcggcgtat 707161 gggatatgaa ttcatgggtg ctgatgcgtc cggatatcat ttgtttgaga aagagattac 707221 ggcagaataa gcgtcctttg cagggggctt ttttgtcttt ttctaaaagg gaggcaggcg 707281 atgtgtggtc aatattattt gtgacaggga ttgtgacggc ttgtctgttt gctggcgtat 707341 ccgtattgat gcggatgaga tttcctgaca aaagtcggcc ggaatggatg ttggccgggc 707401 tgatcgtcct tggtgtgttt gcgatctggt acagcctcgt gtatgtacgc ggctgggaag 707461 gggctgcgct cggaatgctt ggattcaatg tcattttcgg agccattgcc ggatatttga 707521 tcgataaggc catccggcgt tacaggaaaa gataaggctg ctgccgtctc tcaacaggtc 707581 gaaattttca cagaccggca ggaattttct ttcgaaagga gaaatacata ttactttaaa 707641 atgaaagcgt tttccaaagc aggaaggtga tgttgatgat acacagtgtg gcaaatgggc 707701 tgaatcattt ttgtacgtgg gtgatgagac tggcctattt gaatgtgctt tggattttgt 707761 tttctcttgc aggcctggtt gtatttgggc tgatgcccgc tactgccgcg atgtttacag 707821 tggcgagaga atgggcgaag gggaatacag atgccccggt gttttctgtc ttttttcgga 707881 cgtttaaaaa ggaatggcgg gcatcacaga tcctcgggct tatcgttgtg acggctgccc 707941 tgtttctgtt tgcggatatg cggatagcgg ctcagatgga ccagcctgtg ctcgtcaatg 708001 tattcgtgag cattagtttg attttcgcgt ttgttgtgct gtatgtgttc ccggtatttt 708061 ctcattttga cgtaaaaatc agagaggtgc tgagcatcag ctttttcatt gccttcagtc 708121 gtccggcggt gacgcttttg atggcagcgg gcgctgtcgg tgtgctttgt ctcgttctgt 708181 ttcatgtcac gtttctattg tttttcagcg ggagtttact cagcctgatc ttaacgaagc 708241 tgtcctttaa agcgtttcgg tcaatggatc agcggcagga gaaagaaaag gcggcatgaa 708301 gaaaagagtt gctggctggt acaggcggat gaagattaag gataagctgt ttgtgtttct 708361 atcgttgatt atggccgtat cctttctgtt tgtatacagc ggggtccagt atgcctttca 708421 tgtgtatgat gagcagattt accgcaagtc ctcggaggtg cttcggatgt cttctgaaag 708481 gatcgaagac gagctgaaga agatagagga tgtgtcatat gaaatcatta cagacgaaca 708541 gattcagcgc atcctgagca tgcaaaatcg ggatgatacg tatgatcaat atcaaatgaa 708601 gcaggagctg tgggatcagc ttgcgggata tgccagcgat gaaaagtaca tcgattccat 708661 tcatgtgatt gatgcccgcg gctcagagta ttcagccgga agcagttctt cagatctttt 708721 gcagcaggag caggaagagg tatttaagcg agcgaaagcg aaaagtggaa gaaatctttg 708781 gatgacgctc ggcgggtcag accccgtcct gatttcagca cggcagatca ggtcctatca 708841 ccagctgagt ctgaacggct tgggcatggt actgatccag gtcaatgtaa aacagatgat 708901 tcgtgatgtg ccgaaggatt ggggcgattc agtcggagac attatgattg ctgaccaagg 708961 cggtaatttg gtgtatacgg cacatgcatc agcgcatgtt cctgaggcag caaaagagac 709021 gttgaagcac cccggttatg acttgataaa aaagaatggc aaacgttact ttatttctta 709081 tcttcaatca tcctaccaaa attggagcta ctataacgtt atcccctttg atcagatgtt 709141 cgcaaaaatt tcctttatga aaacagtgat cggcacatgc tttcttctct ttttctgtgt 709201 ggttttgctt ttcggaagga aaatcgccaa cagcatcacg gagccgattg aacagcttgt 709261 gaccgcgatg aaatcggtac agcacagcgg cattgaagca ggtgtgtcgc tttctctgcc 709321 ggaacataca caggatgagg ccggcatgct gaaccgccat tttactgtca tgatgaaacg 709381 gattaatgag ctgatggaag aaaatgtgga aaaacagctc atcattaaag aaaccgaatt 709441 gaaagcactg caagcccaga tcaatccgca ttttttatat aacacgctcg agtccatcaa 709501 ttggctggcc aaggcgaatc agcaaaagca aatctcaaaa atggtggaat cgctcggttt 709561 tcttctgcga aacagcatac atatgaagaa ggatatcgtg accattcagg aggaggcgga 709621 cattgtacgt cactatatga ccattcagcg atttcgattt gaagagcgcc tgaaattcac 709681 gttggatatt gacgatgagg tgaagcattg cctcattccg aaactgacgc tccagccgct 709741 tgcggaaaat gcgattcaat acgcgcttga accctttaca aggccatgcg ccatccggat 709801 tcaggcgaaa aaggcgaagg gctgtgtctg tattacggtc gaagataacg gccctggcat 709861 ggatggacgg attcttgaat caacgggtgg aagaggaatc ggactttgga atattcgcga 709921 gcgcatcagc ctgacattcg gagagccata cggattgcgg attcatagtg agcatgaaaa 709981 ggggacgagg attgtgatca caataccgtg ccgaaatgag gtggtgtgat gtataaaata 710041 ctgctggctg atgatgagag gattatcctt gatggaatgg cgggaatcat tgagtgggag 710101 tcgcttggcg cctcattgat cggaaaagcg cagaacggac atgaagcata tgaaaagatt 710161 gtacataagc agccgcatat cgtcatcaca gacgtcaaaa tgcccggcat ggacgggctt 710221 gagctgatca aaaaggtgtc agccgtcagc ccgtcggtgc aatttatcgt cctgtccggg 710281 tttggagagt ttgagtacgc aaaggaagcc atgaaatatg gggtgaagca ttatttgctg 710341 aaaccctgca atgaacagca gattatcagc tcgctggagg aaatcattgc tgagctgaag 710401 cggcaagatg tgcacaaaaa gaaaacagcc catctgaaac acgagctgga ccatatccgt 710461 tcctttgcag ccgatcaata cttggaaggc ttgatcgccg gtgtggccca gctttctccg 710521 ccgccttcac ttgccggaaa aaagatccgc ctcttgatct taaaagggga acaatctatt 710581 gatgctgcag ccagagaggc actcggatcg gcactgacag cggtttgcag cagcggtgaa 710641 tggaccgtgc tcgccgtaga ggagaacgcc gctgaaaagg tggcggaggt ttttgcggac 710701 cgcaagatgg ccatcagtca ggcgggagaa ctccggcacg cggggcagct gtttcgtgac 710761 acagctgaag cgtctggtga cctgcatggg agcgcagtga tttcaaaaat gatcaggctt 710821 attgccgacg agctcggaaa tccgaatctg tccttaaaat gggcggcgaa ggatatgctg 710881 tttatgaatc ctgattatct cgggaagtta tttaagcagg aaacaggcga gaaattttcc 710941 caatatgtta cacgggtgcg tcttgagcat gcgatgaagc agatgaaaat aaggagggac 711001 gtgagcgttt cagaaattgc tgaagaaatc gggtttggcg ataatccgaa gtatttcagt 711061 cttgttttta aaaaatatac cggtctgaca ccgtcagaat tcagaagaaa acagggaggc 711121 gcttccgcag gatagccatc tctgtttttt tgactttcgc cactgttttt tgagtgtttc 711181 gccctatccg aacgctttaa aataaaatgt aagcacttac attaaagggg ggattggttt 711241 gaagaagatt tgttacgtgc tgttatccct tgtctgcgtc tttttgttca gcggatgttc 711301 agcgggtgaa gaggcctcgg gaaaaaaaga agatgttaca ctcagaatcg cgtggtgggg 711361 cgggcagcca aggcatgatt atacaactaa ggtaattgaa ctatacgaga aaaagaatcc 711421 gcacgtccat attgaagcgg aatttgcgaa ctgggatgac tactggaaaa agcttgcgcc 711481 catgtctgcc gccggccagc ttcctgatgt cattcaaatg gataccgctt acttagccca 711541 atacggaaag aagaaccagc tggaagattt aacgccgtat acaaaggatg gaacgattga 711601 cgtcagttca atcgacgaga atatgctgtc gggcggaaaa atcgacaata agctttatgg 711661 atttacgcta ggtgtcaacg tgctgtctgt gattgccaat gaagatttgc tgaaaaaagc 711721 cggtgtgtct atcaatcagg aaaactggac gtgggaggat tacgagaagc tggcgtatga 711781 tcttcaggaa aaagccggtg tctacggttc caacggaatg catccgcctg atattttctt 711841 cccttattat ttgcgcacaa agggtgagcg cttttataaa gaagacggca ctggcctcgc 711901 gtatcaagat gatcagctgt ttgtcgatta ctttgaacgg cagctgaggc tagtgaaagc 711961 gaaaacgtcc ccaacacctg atgaaagcgc acagattaaa gggatggaag acgattttat 712021 cgtcaaaggc aaatcagcga ttacatggaa ctactccaat caatatttgg gctttgcccg 712081 gctgacagac tcgccgctgt ctctctatct gccgccggag caaatgcagg aaaaggcgct 712141 gacactgaag cccagtatgc tgttttccat tccgaaaagc tctgagcata aaaaagaggc 712201 agcgaaattt attaatttct tcgtgaataa tgaggaagcg aaccagctga ttaaaggcga 712261 gcgaggcgtt ccagtctccg acaaggtggc ggatgcgatt aaaccgaagc tgaatgagga 712321 agaaaccaac atcgtggagt atgtagaaac cgcgtcaaaa aacatcagca aagccgatcc 712381 gccagagcct gtgggaagcg cggaggtcat caagctgctg aaagatacgt cagatcagat 712441 tctgtatcag aaggtatcgc cggaaaaagc cgccaaaacg ttccggaaaa aggccaatga 712501 gatattagag aggaataatt gacgggaaat ggggctgacg caatgaaaaa aagccggagt 712561 ataagaaaag acaatctggc gggatatgct tttatttctc cgtttatcat cgggttccta 712621 tgctttacgg tgattccgat gggggcgtcc ctgtttctgt ccttcacgag ctatgacttg 712681 tttacggcgc cgaaatggat cgggctcgac aactttaagg aaatgtttac gggtgacgaa 712741 aagtattggc agtctctgaa ggtgacgttt acgtatgtgc ttgccggggt tccgctccgc 712801 ctcggcttcg cgctttttat cgctgtcatt ttaaacaatg cagcaaaagg aacggccatt 712861 tacagaacgc tcttttatct gccttcgatc atcggcggga gcgtcgccgt ggcgattatg 712921 tggcgcaata tttttggcaa tgacggggtc atcaatgcgc tgctgttttt tgtcgggatt 712981 gatcaaaaaa ttctttggta ccagaatccg acaagtgcgc tgtggacatt gattctgctg 713041 tccgtctggc agttcgggtc gtcaatgctg atttttttgg ccgggctgaa aaacattccg 713101 tcttcgtatt tggaagcggc aagtgtggat ggggcaaatc gggtgcagcg tttcttcaag 713161 atcacgcttc cgatccttac accgattatt ttctttaacc tagtgatgca gacgatttct 713221 gcttttatga catttacacc tgcctatatc atttcgaagg gcgagggcgg gccgcttgac 713281 gggacacttc tctattcgct ctatttgttc cagcgtgcgt ttaactattt tcaaatgggc 713341 tacgcatcgg cgatggcgtg ggtcatgctt gtcattgtcg ggctgattac gctcatattg 713401 tttaaaacat cgtcatattg ggttcattac gagtcaaagg aggaatgacg gatggagccg 713461 gtcaaccagc ctgtcagaga agccccggtt tttgagagaa aaaaagccgg gcgcgtcagt 713521 cccaaacgca tactgttcca tgtttttacg gcaacgctgg cggtgttgct gctgtacccg 713581 gttatttggc tgtttgtcag ctcgtttaaa gaaagcgcca gtatttttac aacctcacat 713641 tctctcattc cagacccttt tattctcagt aactatgctg aagggtggaa gggcattgcg 713701 ggacagccgt ttctgacgtt tattaaaaac tcggcgatta ttgtcgggct gtcaacaatc 713761 ggtgccgtca tgtcatcggc tgtcattgcg tacggatttg cgcgtatacc gtttaaggga 713821 aaaaaatttt ggtttgcgtg catgatgggg acgttaatgc tgcctcatga agtgttgatg 713881 attccgcagt atattatgtt tgcgaaatta gactggctga attcctttaa accaattgtc 713941 gttccgcaat ttttcgggca tgcgtttttt atctttctga tgatccagtt tatccggacg 714001 attcccgagg agctggatga agccgcgcga atcgacggat gcggacgctt tgcctgcttt 714061 tggcggatca ttctcccgct gattgccccc gcgcttgcga cgtctgcgat tttctccttc 714121 tattggaagt gggaggagct gattcagccg ctcttgtatt tgaataagcc ggagctttac 714181 cctgtttcac ttgcgctgaa gctttttctc gatacagagt cggcttcgaa ctggggcgcg 714241 atgtttgcca tgtcagccgt ctcgttattg cctgtgattc ttgttttctt tttgtttcag 714301 aaatatatcg ttcagggcat cagtacgacc ggattaaaat aaaaaggagt gttgcagatg 714361 gcacagctta tctttgatga agaaaaggtg acgtcggtta ttgaccggat cgtgaaacgg 714421 acatttcaga tggattttgc gtgggattgg ccgggcggcg ttgcgtttta cggtgtggcg 714481 gaggcctatg aagcgacgga aaacgaggaa tatatcaatc tgttaaaaac gtgggtggat 714541 gaacagctgg aggatgggct gccgccgctt tcgatcaacg gagtttccat tgggcatacg 714601 cttttgttcc tccacaaggt gacaggtgat gacgtgtatt tggaaacagc ggccgagatg 714661 gcggaatatg tgctgcataa ggcgccgcgc tttggcgagg gtatccttca gcatacggtg 714721 aatgcggcag aatacgtatt ccctgaacag gcatgggcgg atacgctgat gatggctggg 714781 ctgtttatgc tgagaatcgg gcgggtcatg gagcgtgagg attattttga agacggcctg 714841 cgccagtttc acggacatga ggatgtgctt caggaccctg tcacgaattt gtactaccac 714901 gcctgggaca acaaagcgca aaatcatctg tcggggattt attggggcag ggcgaacggc 714961 tgggcggcac tcacgatggc aaaggcgctc ccgcttattg aggtgacaca tccttccttt 715021 atgatcatcg acggatcgct cagagaccag ctgagcgcgc ttgtccggct tcaggatgaa 715081 tcagggctgt ggcatacaat tttggatgat ccggattctt atctggaggt ttcggcatca 715141 gcgggtattg cttctgctct gatgtcgagc ggaaagctgt atacaaaata tgtgcagaaa 715201 tcgcttgccg ccattttgga tgcagtggaa gaggacggac gggtcagcag ggtatcggcc 715261 gggacagccg tcatgaaaaa tgccgaagga tacaaacagg tgccttacaa acgaatacaa 715321 ggatgggggc agggacttgc gctgacgttt cttgctgatg ttttgaaaac gaaaaaacgc 715381 ttgtatcagt aaagatagcg gcggggggag agggatgaaa aaacagcctc aacagaagga 715441 acgggtttct cgctggaagg gaacgtattt caaaagaaac tttgtcttca ttttgctgat 715501 tgcctgtatt cccggattgc tgactggcgg cgcaatctac tttctttcga tcgacaaggt 715561 ggagaaagag ctgcagagat cgcatgaaac acaggtggcg cgtgaggtca gccgaatgga 715621 tgagaagctg ggagtgcttg aactggcact cacccagatg gcctacgatt cttcactgat 715681 gaacggattg gccgagaggg atttggagaa agactttacg ttctcctatc aattaacgaa 715741 aaagctgttt cttttgcggg atcagcagcc gctgatcgag caggcttcca tctttctgaa 715801 cagcccccgg ccacttgtgc tgagccctga atacagcgct ttgacagaac aggaggcgct 715861 tcgcaagtat cgctcgctgc ttgcctcaga ccacagcatt tattggaaac ggtcgggaaa 715921 ccaagcgatg ctgatccagc tcattccggg cgcggcggag aaaccgttcg gcgcgatcat 715981 gctggcggtt gatccgaaag aaatggaatc aatcctgcaa agcttgtccc cctatcctga 716041 tggcagtgcg ttgcttttag atcaaaatcg agaggtgctg tttcatgagg gggaaaaaga 716101 ttttgaaaag actttacttc atgagataaa aaaacagcct gctgagaacg gccattttca 716161 gatggaatgg aaaggcaagg tgtattctgt ctcctttgga gaaatgaacc ggatgcatca 716221 gcaatggacc tttgtgtcag cggcgcctct ttcagctatt acagcgccga tggtgttttt 716281 atcaaaagtg atcatcgtga tgctggtcat ttgcatcggt ttggcggtgt gcatgacatg 716341 gtatgcatca aaaaaaatct atcgtcccat ccagcatttg cttggcttgt ttaccggagg 716401 agagaagaaa acatggcagg cgtccgggca ggatgaattc aaatggattg aaaagagatg 716461 gcaggatcta tcccttgaaa gccggaagct ccaacagcag ctcctgcggc agacgcccca 716521 tatgaaaaag agttttttgc agcatctctt acagagcgat ttttactatg acaacgagga 716581 aagcctcaga tttcggatgg aggaggctgg ctggaacatc ggcggaaacg tgtttcatgt 716641 gcttgatcta caggtgacag ggctccgctg tgaaaaaagc atcttccgtg aaggtgatga 716701 acagcttgcc gtgtttacac tgactaatat cgctgaggaa ttggcggcta aacgcgtttt 716761 tcagctctcc atacttgata tcggccggct ttctgtcacc gttcttgtga tgaaaacaaa 716821 cagctctgat ctgaaggcgt atataacgga gctggcacgc caatttggag atgtaaccgg 716881 actatgcctg acctcgacat tgagcagcaa gacggagcgt gtcacggaaa ttccttcttt 716941 atttcaggat gtgaaatgcg gcaaatcccg caggaagttt gctaaccggg atcaggtcat 717001 tgatttgcag gccgacttcc ctcgggatga gcagttcgct ccttattacc cttttgagct 717061 ggaaaaacaa attgttcaga ccatccggct ggaaagaaaa caggaagcca aggaactgat 717121 agatggatgt atgaaggaac tgtcggaaaa agcggccata gacaggcatg tgcattccgc 717181 cctgattcag ctgttttccc gcattcagga ggatattttg cattccgggc tcaatcccag 717241 cgaactgttt cagcaccgga atccgtttct tgatatttca gaattgcgcg aacctaacga 717301 agcggcggcc tggctgatgg atgtagtggt gacgccttac ctttccaagc ttgagggcag 717361 aaaaaacaga cagcaaaagc agctggcaga acgtgtgatt gcgatgattc acgaacagta 717421 tatggcggac atttcattgg aaagctgtgc cgatgcgctt ggcatgaatt cctatacgtt 717481 aagcaaggca tttaagcaag tgaccggcat taattttatc gattatgtga cccagatcag 717541 aatcgaaaag gcgaaagaac tgctggtcaa tacgaataaa aaaattcatg atgtgtctga 717601 agaagtcggc tatcgccaca attatttcaa tcggattttt aaaaaacagg tcggcatgcc 717661 gccgggtgtc ttcaggcaaa tgtatcagga aacgccgtga aaggagagaa catgtgatga 717721 agaaaccgat tcaagtattt ttagcggggg attccactgt gagtgactgc ccgcctcatg 717781 aagcgccgat ggcggggtgg gggcaggtat tcgggcaatt gttttctgaa ggtgtgctgg 717841 tccgcaatca tgccaaagga ggagcgagca ccaattcttt tgtggaggaa ggaaggcttc 717901 aagcaattgc cgagcacatc acacaaggcg attatttgtt gattcaattc ggccacaatg 717961 accaaaaacc gcgggggacg aagccgtact ccacatttca gcagtttctt accttgtttg 718021 cagatacggc acgcgaaaag ggcgcgcatc ctgtgttcgt cacatcggtg cagcgccgcc 718081 gctttgatga aaacggacgg atcgagcata cgctcggtga gtatcccgat gcgatgaaag 718141 cactggcgaa ggagctcgat gtacctgtga ttgatctgct tgcgaaaaca aaggtgctgt 718201 atgaagcata cgggccggag gagtcgaagc gattgttcgt ttggtttcag ccgaatgaac 718261 atccgaatta cccggacggc attgaggaca atacgcattt ttcggaaaaa ggtgcaatgg 718321 aggttgcgaa gcttgtggca gaaggcattg aagagctcgg acttccgctt aaggaccacc 718381 ttgtgagccg ggagggaaaa gaacatgtat aaggaaggcg cttgcttgta ccgcaatccg 718441 ctccggtcta aaagcgatgt gaaggattgg cggatggagg gaggcggaca gatctcattt 718501 gacgatcaca gcttgcacct gtcacatgtc caggatgaag cgcactttgt cttttggtgt 718561 ccggaaacct ttccagacgg catcattgtg acatgggact tctctccgat cgagcagcct 718621 ggactgtgta tgctgttttt tgccgctgcg ggtattcgcg gcgaggattt gtttgaccca 718681 agtctcagga aaagaacagg aacataccct gagtatcatt caggagatat caatgccctc 718741 cacctgtcgt atttccgcag aaaatacgcg gaggaaagag cgttccgcac ctgcaattta 718801 agaaaaagcc gcggtttcca tctcgccgca atgggggccg atccgctgcc ttctccagac 718861 gacgctgatt ctccgtatcg tatgaagctg atcaaagaca aaggctatgt gcacttttca 718921 atcaatggtc tgcccattct tgagtggatg gacgacggca gcacatatgg gcctgtgtta 718981 acaaaaggaa aaatcgggtt ccggcagatg gcccccatga aagccgttta cagggatttt 719041 gccgtgcatc aagcggtgag aagatgaaga cgactgtaac ggatgcgctt tatgcaggct 719101 gcgaagcggt ggtgaaaata gcatggctca acgggctgtg gctgttgttt acacttttgg 719161 gcggcgttct tttcggatgg gcgccgagca cagctgcgat gtgtgccgtt ataaggaaat 719221 ggctgatggg gcaaaaggat gtcccgatat tttcgttatt tctcgatacc tataaaaaag 719281 agtttctcaa ggttaatgcg atcggattgg cgttttcggc tcttttgctc atattgtctg 719341 ccaactatca ttatttttct gccagtacga attggctgtc ctttgccgta acaagctgca 719401 cgctgcttgc agggcttttg tatatcatcg cgctgatgta tgtgtttccc ctttatgtgc 719461 attaccagct cccgcttcgc aaatatattc cgcaggcact gctgtttggc gccatgagac 719521 cgctgacaac tggctgtatg ctgatcgggt gcggatttgt cctttatttg ctgtatacgc 719581 ttcctggcct gatcccattt tacggcccgt gtttatttgg gcttgtgttg atgttttttg 719641 ctcttagggg atttcaaaag acggaggccc agcaccatca agccgggtaa caaaaaaatg 719701 acaaataagc aaaaaagtgc agtgtccgaa ataggcagat gcaaaaaagt gaaattgaag 719761 acagctcaca aagcgcataa aatccaattt aagtaagcgc ttacagataa atgagaagga 719821 gctgtctgat gattagacga aggaaacgca tgtttaccgc tgttacgttg ctggtcttgt 719881 tggtgatggg aacctctgta tgtcctgtga aagctgaagg ggcagcgcgg cagatggaag 719941 cgctgaaccg ggggcttgta gcggtcaaga cggacggggg catttttgtc agctggcggt 720001 ttcttggaac cgaaaacgca tctgttttgt tcaatgtgta cagagacggg caaaaactga 720061 atgctgcgcc tgtcaaaaca acgaactatg tggataaaaa cggttcggcg ggctcaacgt 720121 atacggttcg ggctgttgta aacggtaccg aacagccggc ttctgaaaaa gcctccgtat 720181 gggcgcagcc gtatcattcc gtcccgctgg ataaaccggc tggcggcacg acgccaaagg 720241 gtgaatctta cacgtacagc gctaatgacg caagtgttgg cgatgtggat ggtgacgggc 720301 aatacgagct gatcctgaaa tgggacccgt ccaactcaaa agacaattca caggatggct 720361 atacgggtga cgtgctgatt gacgcgtata aactggacgg cacaaagtta tggcggatca 720421 atctcggcaa aaacatcaga gcgggcgcgc actacaccca gtttatggtg tatgaccttg 720481 atggtgacgg aaaagcagaa gtggcaatga aaacggcaga cgggacaaaa gacggcacgg 720541 gcaaagtaat tggaaatgcc aatgcagatt acagaaatga acaggggcgt gtgctttcag 720601 gccctgaata tctcactgtg tttcaaggtt caaccgggaa agagcttgtc accgcaaatt 720661 ttgaaccggc gcgcggcaat gtgtcggatt ggggagacag ctacggcaac cgtgttgacc 720721 gttttctcgc cggcattgcc taccttgatg gacagcggcc gagcctgatc atgaccagag 720781 ggtattacgc taaaaccatg ctagttgcct ataacttcag ggacggaaag ctgtcaaagc 720841 tttggacgct ggactcctca aagtcaggaa atgaagcgtt tgccggacag gggaatcaca 720901 acctgagcat cgcggacgtt gacggggatg gaaaagatga gattattttc ggctcaatgg 720961 ctgttgatca tgacgggaaa ggcatgtact cgaccggctt aggccatggg gatgccctcc 721021 atacaggaga tcttgatccg ggccggccgg ggcttgaggt gtttcaagtt catgaggaca 721081 aaaatgcaaa atacggctta tctttccggg atgctgcaac tggaaaaatc ctttggggcg 721141 tttatgccgg caaggatgta ggccggggaa tggctgctga tattgacccg cgttatccgg 721201 gacaggaggt gtgggcaaac ggttctctct actcagcgaa aggggtcaaa atcggaagcg 721261 gggttccgtc ctcgaccaac ttcggcatct ggtgggacgg cgatctgctc cgggaacagc 721321 tggacagcaa ccgaattgat aagtgggatt atcaaaacgg cgtatcgaaa aatatgctga 721381 ctgcatcagg cgcagcggct aacaacggca caaaagcaac accaacgctt caggctgatc 721441 tgctcggtga ctggcgcgag gaagtggtgt ggagaacgga ggacagcagt gctctgcgca 721501 tttacacgac gaccattccg actgagcaca ggctgtatac gctgatgcac gatccggtgt 721561 accggcttgg catcgcctgg caaaatatcg cctataacca gccgccgcac acaagcttct 721621 ttttaggaga cggcatggcg gaacagccaa aaccaaatat gtatacgcct taactgaaag 721681 ggggaaggaa cgggctgcgc gcagcccgtt cccatcaaat gaaaccaaaa aagaggcaaa 721741 tggaatacct gaccagaggt ttgattgcgg tacagacaga acagggcgtg tttgtcagct 721801 ggcgttttct cggcacggat catgagacga cggcttttca cctttatcgg gatggaaagc 721861 ggatcacccg cgatccaatc gctgaaagca ctaattttct cgatcaaaac ggaacggctg 721921 actctgttta tcaagtggcg gctgtcaata aaggacggga agaaaagctt tccaagaaag 721981 ctcgtgtttg gcaggaaaat gtcctggagg ttcctcttgc caaaccggaa ggcggtgtga 722041 cgccggacgg aaagccgtac acttacagcg ccaatgatgc cagtgtcggg gatatagacg 722101 gggatggaga atatgaaatg atcctgaagt gggacccgtc caattcaaaa gacaacgctc 722161 atgacggtta taccggggag gtgctcatag atgcctataa actggacggc acctttttgt 722221 ggcgcatcaa cctcggcaga aacatcagag cgggtgctca ttacacgcaa tttatggtgt 722281 atgaccttga cggtgacgga aaagcagaaa tcgccatgaa aacagctgac ggcacaacag 722341 acgggaaagg acatatcatc ggtgatgagc aggccgattt tagaaacgaa cagggcagaa 722401 ttttgtccgg tccggaatat ttgaccgtgt ttaaaggaga aaccggtgag gcgctcacga 722461 ccgtggaata tgaaccgccc cgcggcaagc tggaggattg gggagacggc tatggaaacc 722521 ggatggaccg ttttctcgcc gggaccgctt atttggatgg ggagcggccg agccttgtta 722581 tggcgcgcgg ctactatacg agaaccgtgc tcgtggcata cgatttcaga aacggaaggc 722641 tcaaaaaacg atgggtattt gactccaacc agccgggaca tgaagcatac gcaggacagg 722701 ggaaccacag cttgagcgtg gcggacgtcg acggagacgg aaaggatgaa atcatatacg 722761 gcgcaatggc tgtcgatcat gacggaaccg gcctgtactc aacgggcctc gggcacggag 722821 acgcgatgca tgtaggggat ctggacccgt cacgaaaagg gcttgaagtg ttccaggtgc 722881 atgaggacgc cacgaagccg tacggactgt cgctgcgaga tgccggaacc ggtgagatat 722941 tatggggcgt ccatgctgga actgacgttg gccggggcat ggcggctcat attgatccaa 723001 gctacaaagg atcgctcgtc tggggaattg atccgccggg caatgatggc atgtcgtacg 723061 ggcttttcac gagcaaaggc gaaaaaatca gcgacaaagc gccctcttca gccaatttcg 723121 ccatctggtg ggacggtgat ttggtcagag aactgcttga tcatgactgg gacggaacga 723181 tcggcaggcc aaagattgaa aaatgggatg ctgaaaacgg ctgtctgaag acgatatttc 723241 agccggccgg cgtgttgtcc aacaacggca cgaaaggaaa cccggttctt caggccaacc 723301 tgttcggaga ctggcgggaa gaagtgatat ggagaacgga agacagcagc gcgctccgta 723361 tctatacaac aacacatctc acccgccact gcttttacac gctgatgcat gatccggttt 723421 acaggctcgg catcgcctgg cagaataccg cctacaacca gccgccgcac acgagctttt 723481 acctcggaac gggaatgaaa aaaccgccga agcccgccct gtacatagcg ggaagcaaag 723541 cggaggcgcc gctgtaggag gactaaggga taagacgcaa aggctgaacg ctacgccaag 723601 atgattagag aactggcagg acgaaccaat gctcaagcgc tgtacgcacc ggttttttca 723661 agggaagagc tatccgtgat ggaagctgta taaaaaacga ggaggaatga aaaaatggca 723721 aatcatattt atcttgccgg cgattcgact gttcaaacgt atggagacag cacaaatcaa 723781 gggggctggg ggcagtttct cggctcgcat ctgccggagc atattcaagt gatcaacaga 723841 gcgatcgggg gaagaagctc gaaaacattt gtggaagagg gcaggcttca ggcaatcctc 723901 gatgtgattg agccggatga ttggctgttc gtgcagatgg gccataatga cgcgtcaaaa 723961 aataagccgg agcgctacac cgagccctat actacttata aacaatattt aaagcagtat 724021 atcgcaggcg cgcgggaaaa aggcgcccat ccgcttctca ttacccccgt agcccgcttt 724081 cattacgaaa acggcgtgtt tttgaacgat tttcctgatt actgcattgc catgaagcag 724141 acggccgctg aggagaatgt ccagctcatt gatctgatgg agaaaagtct cgctttcttt 724201 actgagaagg gcgaggaaaa agtgtacacc tattttatga tttcagaagg gattaacgat 724261 tacacgcatt ttacaaaaaa aggcgcaaat gaaatggcga aacttgtggc aaaaggcata 724321 aaggagctcg gcctgccatt gacagaatcg atcatcaaag aaaggtgaaa atgtgatgag 724381 aaaactgtat catggcgctt gctattatcc ggaattatgg gatgaagaga cgattcagca 724441 ggacattgac atcatgcgtg aagttggcgt aaatgttgtg cggatcggcg aatttgcctg 724501 gtcagtcatg gaacctgaag aaggaaaaat tgacgtcggt tttttcaaag aaatcatcgc 724561 ccggctgtat gatagcggga tcgaaacgat tatgtgcacg ccgacgccta ccccgccgat 724621 ttggttctca catggccggc ccgaacgcat gcatgccaat gaaaaaagag agatcatggg 724681 gcatggctcc cgtcagcatg cctgtacgaa caacccgtat ttccgaaaaa aagccgccat 724741 catcaccaca gccatcgcca aggagcttgg ccggctcccg gggctgatcg gatggcagct 724801 agacaatgag tttaaatgcc atgttgcaga atgcatgtgt gagacatgct tgcgcctatg 724861 gcatgactgg ctcaaaaatc gctacggggt aattgagcgc ttgaatgaag cttggggaac 724921 cgatgtgtgg agcgagacct atcagacgtt tgagcaagtc ccgcagccgg gaccggcccc 724981 gtttctgcat catgcctctc tacgcactat gtatcagctg ttttcgatgg agatgatcgc 725041 ttcgtttgcg gatgaacagg ccaaaatcat ccgctgctat tcagatgcgc cgatcacgca 725101 taacggatca gtcatgttca gcgtggacaa tgagcgaatg tttcagaatc tcgattttgc 725161 ctcctatgac acgtacgctt cgcaggaaaa cgcctctgcc tttttattga actgtgattt 725221 atggagaaat ctgaaacaag ggcgcccgtt ttggattttg gaaacgagtc cgtcgtatgc 725281 cgcctcgctt gaaagctccg cttacccgca cgcagacggg tatttgcagg ccgaagccgt 725341 atcgtcctac gccttaggga gccaggggtt ttgctactgg ctatggcgac agcagcgttc 725401 aggcagcgag atttcccacg gttcggttct cagtgcctgg ggcgaaccca ccatcggcta 725461 tcaaaatgtg ctggcggttg agcgggcaag aaaggaaatc gagcctatta ttctatcgac 725521 tgaacccgtt caagccgagg cggcgatgac ttactctgac agagcaaaag catttattaa 725581 aactgagcct caccggggac tccggcatcg ttcgcttgtg acgcattttt atgaacgtat 725641 tctcaacacg gggattcacc gtgaccttat tccggaaggc gctccactgg acggctatcg 725701 cttgctgttt acgccatttg tgccgtattt gtcttctgaa tttatcaaaa aagcttcggc 725761 attcgctgaa gcgggcggca tctggatcac cgggccgctg acaggaggac gcacatgcga 725821 gcataccatt cataccgatt gcggacttgg cgaacttgag aaaacgtcag ggatcaaaac 725881 actttttacc tttccgatga atgagaacgt gaatacagga aaagcgtttg gcatcacggc 725941 gccgctcgga ctgtggagcg cggtgtttga cacagagagc ggaaacaccc ttggcacggt 726001 tgaagcagga ccgggggcgg gccatgcttt tctgacggaa cggaattacg gcgaggggaa 726061 aattgtcatg ctgggctcgc ttccatccgg gaaagaaggg gatgcgatgc tggaagcgct 726121 cgtcaggcat tatgcggagg aagctgttat ttccagccgg tcggatgtga cacccggcac 726181 gatcgttgcc ccgcgtatag gcgaaaacgg ccttgtgtgg atcgttgtga atatggatgg 726241 aaaaggcggg agcgtgacat tgccggaatc gggaacggat ttgttgacgc accgcttgga 726301 aaaggcgggg agactggcgg tcggaccgca tgaataccgt gtgattcaat ttgacaatca 726361 cagctgattc tttgtatcga atcagctttt ttctatggag ggagagacag atgaaaaaga 726421 tcaaatggtt atcaggacag ccaaaggtga caagcggcgt gacgtggggc atgccatgga 726481 aaaaaggaga attaaaaaaa ggagaccgtc tggcgcttat gaatgaaaac gcggaaacgc 726541 gatatgtgca aagcgaaccg tcggcctatt ggccggacgg gagcatcaag tggacgaagc 726601 acgcggcggt gtttggcggt caggaaaacc aaagctttac agtgcacaaa agagaagtgc 726661 cgcagccaac tgaatcgctc agcattcttg agacagagca tgatatccaa gtggatacag 726721 gagcactcgt ttgtaccatt cataaaacag gatctgattt cattcaatca ttgcagatca 726781 atggaaagcc gatcgccgca ggcgggaggc tcgttgcgat aagagaaacg agaaaagagt 726841 cagcggcgaa aatggttctt ttgcatgaaa ggtctgtcag ctttatcaaa cgggcggcga 726901 ttgagcagag tggtcctgtc aaagcagtag tcaaaatcga gggagtgcat gtgcttcata 726961 aaacgtatga ggaatggctg ccgtttgtca tccgattaac gttttatgcc gggctgtctg 727021 agatcggcct tgtgcacacg cagctgattg acaggagcgg taaactagaa ttcgttaagg 727081 ggctcggcat cgaattcgac ctttttttgg agggagagcc gtacaaccgc catttccgct 727141 ttgcgggaga gaaagggatg tataaagaac ccgcccagct gtttggcaca cgtaaattca 727201 atgaacgata tccgctttat gaaaaacaaa tcaatggcga aatgctgtct ccagatgaag 727261 agcataagga atggtttgca catggcacac agaatgcggt ttgggacgat gtcaagatcg 727321 tgcaagattc cagcgatcat tacagcctgt caaaacggac cggaaaagat tatgcgtggg 727381 ttggaatgct gcatggcagc cgggcgaagg ggctctgcta tgcgggcgga aaaaatggcg 727441 gtgtggctct cggcctgcgg tatttctttg agaaatatcc ttcagcactg gaaatcacag 727501 gtcttgccgg cagccgcccc aaaatgacta tctggctttg gcctccggac ggcgaagcga 727561 tggatttgcg gcattataca ggaaacactc acgtggccag cgcgtatgaa ggctttgatg 727621 aaatgcgctc tgatccgaca ggcattgcga acacaaatga aataagcctg gcgtgctttt 727681 cgcacatgcc gtctgacgaa gtcctcaatg cgctggctga caaatggcag gcgcccccgc 727741 tcattgtatg cgagccggac gtctattacg aatcaaaagc actcggggta tggagcatca 727801 ttgacacatc ccatccgctc aaaaaagagc tggaagaaca gcttgatgcg gcctttctgt 727861 tttataaaaa ggaagtagag caacgcagat ggtacggttt ttggcattat ggcgatgtca 727921 tgcatacgta tgacccgatc cggcatatgt ggcggtacga tctcggcgga tacgcatggc 727981 aaaacaatga gctcgttccg accctatggc tgtggcaggc gtttttccgc tcaggcagag 728041 aggatatctt ccgaatggca gaagccatga cccgccatac gagtgaaacg gacagctttc 728101 acctcggtga atatgccggg cttggctcac ggcataatgt tgtgcactgg ggatgcggct 728161 gcaaggaagc gagaatcagc atggccgggc ttcataaatt ctattattat ctgacgggtg 728221 atgaccggac gggagatctt ttgacagaag tgaaggatgc cgattatgcc cttgtcaaaa 728281 ccgatccgat gcgcgctttt tacgagaaag gcaagcaccc gactcacgcc agaacgggac 728341 cggactgggc ggcgttttgc tcgaactggc tggcggaatg ggagcggacc gaaaattcgg 728401 aatatctcaa aaaaatcgaa acgggaatca actgtctgaa gcggctgccg ctccgcttat 728461 tatctggccc gacatttgaa tatgatccgg cgacctcgat gcttcatcat atgggagacg 728521 gcattgcggg cggatatcat atgatcattg ccttcggcgc gccgcaagtg tggatggagc 728581 tggctgagct tcttgatgac tgggaatggg aggatatgct gagtgaattc ggcgaatttt 728641 acacactcag tgatgaggaa aaacgaaaaa aaagcggagg cgctcttcat gacgggcatt 728701 ttcactggcc gatgttcgcc gccggtatga cagcctacgc cgcaagaaaa aagcaagatc 728761 ctcatctcgc cgccaaagcg tggaatcttt tgctagaaga taagctcagc catacgccgc 728821 ttccgatcaa accggagcgc atcgagacat ggacgcagct agaggagctt ccatgggtga 728881 caacgaacac tgtctctcaa tggtgtttaa atgtcatagc ggcgctggaa ctgatcggag 728941 attcccttcc ggcaaaaaaa gaaacatcgg gcaaaaaagg ataacagccg gaatttcata 729001 ggagaaatgg tgcaaaaaat gaagattgca agaatttatg taagcgcttt atattgagag 729061 gggcaaaggg gaaatgcaaa ttgaaaaaag ggggacttac gcaacatgaa aataagaatg 729121 cgaaaaaaat ggatggcctt gccgcttgct gccatgatga tcgccggatg cagccattcg 729181 gaaacatcca attcagcaag cggttcgaaa gatacgatca aaattatggc gccgctctta 729241 tcgccggaaa gcccaagtga taagagccct tcattaaaag cgctcgaaaa atacacaggc 729301 aaagagatta aggtcacatg ggtgcctgat tcatcctaca acgacaaatt caacatcgtc 729361 atggcttcag gagagatgcc tcacgcgatt gtcattaaag ataagtcagc cggctttatc 729421 aaatctgtca aagcaggggc gttttgggag ctgtctcctt atttaaaaga ctacaagaat 729481 ttaagccagg cagatgaaaa gattttgaag aacagctcgg tgaacggcga ggtgtacgga 729541 atctacagaa cgagggatct gatcagggcg tgtatgatca tcagaaccga ctggctgaaa 729601 aatgtcggtc tggatatgcc ggaaacgctt gatgatttct atgaagtgct gaaagccttt 729661 aaggaaaaag atcctgacgg aaacggcaag gatgatacgt acggcatggt cgtgccgaaa 729721 tggatgggac tcggcaacgg aagcccatgg gatgttctgc aaatctggtt cggcgctccg 729781 aaccgctacg gtgttgaaaa cggaaagctg attccagatt ttacaacgaa ggaatacatg 729841 gatgcgctca cgttttttaa aaagctctat gatgagggct tgatcaataa ggactttgct 729901 gtcatggatt ctgcgaagtg gaatgatccg gttgtaaaag gaaaagcggg tgtcatcgtt 729961 gatacaggct caagagcgtc tcaaatccaa agcgcgatgg aggaggcgga tgagtcgaac 730021 aaggatatca ttgatatcgt cggctcgctt gagggaccga atggcaagcg caccttcccg 730081 acatctggtt attcaggcat gatcacgata ccaaaatcaa gcgtcaaaac cgaaaaagag 730141 ctgaaagagg tgctgtcctt cctcgataag atgaatgata aggaagcgca gattctcacg 730201 aacaacggag tgaagggccg caattacgag ctcaaggacg gcgtattcac ctcacttgaa 730261 aaaaacaata aatctctcct gtatgagcat gaaggcttgg cacagttcag catgtcgatt 730321 ccgaaaagcg agtattacat cgaagaccag aaaaccaagc tcttccagca tcgcaaggac 730381 atcataaccg aaggagaaaa aatagccgtc tttaaccctg ctgagtcgct tgtatctgat 730441 gtctataccc aaaaaggagc ccagcttgac aacatcatcc tcgacgcgag aacacaattt 730501 atcattggag aaattgatga aaaagggttc gatgatgcgg tggagctttg gaaaaaaagc 730561 ggcggcaatg aactgatgaa ggacttgaac aaattgtacc aatcgtcaaa ataaaccgat 730621 gcgcctgcct ttcggcgggc gccccggtat cacgaaagga gaacagatat ggaaacagtg 730681 ccgaagaaga gagatgcacc tgttctcacc gctggaaaag gcatcagctg gatggctgcg 730741 ctcaaacggg acaaatggct ttatcttctt cttattcccg gtctgcttta tttcttgatt 730801 ttcaaatact tgccgatgtg gggtgtgctg atcgctttta aagactattc gccatatctc 730861 ggcttctgga aaagcgaatg ggtcggcttt gattatttca aagacttttt tatgaatccg 730921 gattttttcc ggctgctgcg caacaccctc atgctggcga gtctggatct tttgtttgcc 730981 tttcccgcgc ctctcatttt ggctctgctt ttgaatgagg taagaaaggc cgtgtataaa 731041 agatgtatcc aaacctttat ttacgtaccc cattttgtat catggacaat tgtggtcagc 731101 atcaccttcg ttttctttac tgtcgataca ggtgtgatca acaaattgat tatgagcctg 731161 acaggtgagc agatttcttt cttgtcggat gcagactggt tccggccaat gattgtgatg 731221 caaagcattt ggaaggagac aggctgggga acgattctat ttttggcagc gcttgctacg 731281 gttgatcaag agcagtatga agcggccatc atggacggag cggggcggtt caggagaatg 731341 tggcatatta cgctgccggc gattagaagc accattatcg ttttgttgat tttaagaatc 731401 ggcagctttt tgaatcttgg ctttgaacag gtgtatttga tgacgaactc actcaaccgc 731461 agtgtggctg acatcttcga cacgtatgtg tacatgatgg ggattaccca aggggcgtat 731521 agctacagca cggcggtcgg tttgtttaaa tcagttgtcg ggattatctt gatttttggc 731581 gccaattaca ttgcgaaaaa gtttgatcag gaaggattgt tttagaggag ggagaggtat 731641 ggctgaaatt cacacgatgc acaacaccaa agccggacgg gtgtttgacg tctgcaacat 731701 tctgtttctc ggcggtgtcg gcgcgattac cattttgccg tttttatata ttatcgccgg 731761 ttcctttgcg acagaagcgg aactcgccca gcggagcttc tttattttcc cgaaaacctt 731821 tacacttgat gcttacaagt atgtgttttc gacaccgacg ttccttcgaa gcatgggcgt 731881 gtccatcttc atcacggtgg ttgggacggc tgtacagctg ttttttacct tcacgatggc 731941 gtatccgctg gcgaaacggc atgtgaaggg acggaatctg ctgttgaatc tggtgatttt 732001 ctccatgctg ttttcaggcg gcatgattcc gacgtacctt gtcgtaaaat cacttggcct 732061 tttggatacg tattgggcat tgattctgcc gatggcgatt aatccgttca accttattat 732121 tatcaaaaac ttctttcagc agctgccgcg cgagctggag gaatcagcaa aaattgacgg 732181 ctgttccgaa atcggcgtct tctggcggat cgccctgcct ctgtcaaagc cagttattgc 732241 gacctttgcg ctgttttatg cggtcgggat ttggaatgat ttcttccacg ctctcttata 732301 tatcaatgac agtgcaaaat ggccgctgca aatggtgctt cgccaagtca caattttatc 732361 ggatttaacg gcgaccaatg gtgatacgat gcaaaatgca gttccgccgg agcagggaat 732421 taaactcgct gtcattgtca ttgcgacgct gccgattttg gcggtctatc catttttaca 732481 aaaacacttt gcaaaaggaa tgctgatcgg ttcggtgaaa ggctgagaaa gggagtgttt 732541 catatcagta cattagatca gattaagatt gcctatatcg gcggggggtc ccaaggctgg 732601 gccagaagcc tgatgagtga tttgtcgatt gatgaacgga tgtcaggcac ggtggcgctc 732661 tatgatcttg attttgaagc cgctcagaaa aatgaagtga tcggcaatca cagcgggaac 732721 ggcagatgga gatatgaggc tgtttctact ttgaaaaagg cgttatcagc cgcggatatc 732781 gtcattattt ccattttgcc gggatcactg gatgatatgg aagtcgatgt gcacttgcct 732841 gagcgctgcg gtatttatca gtctgtaggt gatactgtcg ggcctggagg gatcatcagg 732901 ggcttgcgtg ctgtgccgat atttgcggaa attgcccggg caataagaga ctacgcacct 732961 gaatcatggg tcattaatta tacaaacccg atgtctgtct gtacaagagt gctgtataaa 733021 gtgtttcccg gcatcaaagc gattggctgc tgccacgagg tattcgggac gcaaaagcta 733081 ttggcggaaa tggtcacgga aaggctgggg attgaggtgc cgcggcgtga ggatatccgc 733141 gttaatgtgc tcggcattaa ccattttaca tggatcacaa aagcctctta ccgccatatt 733201 gacctgttgc ctatattccg tgaattcagc gcgcactatg gggaatcagg atatgagctg 733261 gagggggaat gctggaggga cagcgtcttt tgttcggcac accgtgttgc gtttgattta 733321 tttgaaacgt atggcgccat ccctgctgcg ggtgacaggc atctggcaga gtttcttccc 733381 ggcccatacc tcaaacagcc tgaagtatgg aaatttcatc tcacacctat atcattcaga 733441 aaacaagaca gagctgagaa acgacaagaa acagaacggt tgatcgtgca acaacggggc 733501 gttgctgaga aagcttcggg agaagaaggc gtgaacatca tagcggctct tctcggattg 733561 ggtgaactcg tcacaaatgt aaatatgccg aatcaaggcc aggtcttaaa ccttcctata 733621 caagccattg tcgaaacaaa cgcattcatc acaaggaacc gtgtccagcc gattttgtcc 733681 ggagcgcttc cgaaaggtgt ggaaatgctg gcggctaggc atatatccaa tcaggaggca 733741 gtggcggacg caggtttaac aaaggatact ggcctcgcgt ttcaagcctt cctcaatgac 733801 ccgcttgtcc agattgaccg cagtgatgca gagcagcttt tcaatgacat gctccaatgc 733861 atcatgcaaa gctgagcttg ccgattagct ctttccggtt tagaaaggaa agcattgacc 733921 atactgatag tataatcaag aagtaggtgc tatcaatatg ggaaattatt taagtgttgc 733981 ggtagaactg gtctgcggtt taggcatttt atttatcatc ttaaagcttc tcgggaaaac 734041 ccaattttct caaattacgc cgtttgactt tatttctgct ttaattttag gtgaattggt 734101 cggaaatgcc gtctacgatc atgaaatcaa aatcaaagaa attatttttg cttcgctatt 734161 gtggggcgtg ctgatttata ttattgaatt tatcacgcaa aaaatgaaat catcgcgaaa 734221 gttcttggag ggcgagccga atatcgtcat ccgcaaaggg gagcttcaat ataaagtaat 734281 gaagaaaaat aagatagaca ttaaccagct gcaaagccta ttgaggcaag ctgggagctt 734341 ttcgatccaa gaagtagaat atgcgattct tgaaacaaac gggatggtca gcgtgcttcc 734401 aaaatcagac tttgacaaac cgacaaataa ggatttgcag attccttcga agtccgtttc 734461 tctgccgatc acgttaatca tagatggaga gattgtgcgg gataatttga aggaagcagg 734521 tgtggatgaa cagtggctga aacaagaatt gaaaaagaag aacattgata agacagagga 734581 cgtgttattt gcagaatggc ataaaaataa gccgctgtat actgtaacgt acgaacaaag 734641 cagatcaaca tgactcttag aaaaaagctt gcagcaaggc gcaagctttt tattgattgt 734701 atgtcccttg tttgacagca cgtacatggt acatgctcac ttcagtgctg atcagatagt 734761 caggctttgg tttgcctttg tttgctttat ggccggcgat atgcgcatcg cttttttccc 734821 attgcttcca gtgatcctct gattcccagc gaatcatgac aacaacttct tcatcaccgc 734881 ggcgcacatt tttctcaagc actgtcacat caattaaacc ttcttgtttt tcaatgattc 734941 cttcagcgct gaaacgttct atgactttat ctgcaaagcc ttctttaacc gtcatttttc 735001 tcaactgtac aaacatttgt ctcactccaa tcattctcac atatgaataa ttgtaaatga 735061 aattcattct caatgtcaaa gaaagcgcag ggcggaatcg aaccgccgtg cgcaacagtt 735121 tattctttta ataaaaacac atttccgtct tcgtccttaa attgaacgaa ggtgccccac 735181 tccatttgat tgggctcacc gagaaattct acaccgtttg tcttcatttt ctcgtatgta 735241 ccaaagatgt cttcgcattc aaacacaata gaagccttca tttgctctga gcctttcatc 735301 atggctttcg ggtaaatgac taaacgagtc tcggctcctt ttggcgcaac ctccagccag 735361 cttgcttcag gtcccattgg gtgatccgct gcaatatcaa agcctacctt ctctgtccaa 735421 aattgcttcg ctttctgctg gtcctcgaca tatacagcaa cagtgccaat ttgtttgatc 735481 atagggaaac ctccaagttg aaaagataat aatactataa cctgtttacg gccgaagtaa 735541 cataaaaaaa tcagccggga aaccggctga ttattaaaat gagcagctta caacatcgat 735601 gtgatttgtg tctaaggcga aataaaccca gcggcgccgt gaggaatccc aataaaagcc 735661 gccgacggat cttctgccaa ggatgatcgg gtaaaaccaa aatgagcggc cattggttaa 735721 ccagacatag gtaaatcgga aaaggcaagg acgaatggtg attggttcaa ctaacaaaac 735781 ggctccttga gaaccctgcg gttttggggg tttcgctggt atttgggaag gaggaggtcc 735841 ctgcggcgca ccgccgaagc ctgggctggc accgctgcca ataccagggc cggagccgcc 735901 gccaaagcct ggaacagcac caccgccaat gccaggaccg gagccgccgc cagagcccgg 735961 aacagcgccg ctgccaatgc caggccatgg atatcggtat tcatattcaa aagcaggcca 736021 aggctcataa aaatgccccg caaacatata aggatcaaca taatacatgt gataacgtcc 736081 tttctcattg taaactgtac attgcagttt atgcgggcgg actcttattg gtgcattcgc 736141 ctaaggatat gaagctggaa tgctctcaga gagcagaatc atttgatttt tctctagtct 736201 tattcacaat tccgatttat cattttataa tgaaagtgct tctattacga aaaaggagac 736261 agaccgtgaa tatcgatcaa ttattatatc aatatatcat agacaacact gcggatatta 736321 ctgagaaatg gttcagtttg cgttgccagc taaaaggcga gctatattcc gccagccatt 736381 taagtgaaga aacgaaaaca cttttaaccg agcagcatac atttaccaat ataacaatcg 736441 caagcgcatt tctggaggat caaaccgatt ttcaagaaaa catgacaaaa tgggcgcaaa 736501 acgttgcgaa aaacagggta gagcaggatg ttcaagtgca tgaggtcgta gaagccatat 736561 ccaattcaag aatctcattc tgggacgcag tcgccacatt tataaaagag aatcaggaga 736621 ttgtgacaaa tgaggatgca gaccgatgga accgcattgt gaatcagtcg ttcgataagc 736681 tgattattga attctccgag cagtaccaaa aattcatgct gatgaggctt acatctcagc 736741 aggaactgat ctcagagctt ggctgcccgg tcatttccat tgccgatgga atcgggatat 736801 tgccgcttat cggctccatt gatacaaaac ggcacaggtc attttagaaa cagtgccggt 736861 ccgctgtgtc gagagaaaaa tcacaagcct cgtcgttgat ctttcgggtg ttccgattgt 736921 ggataccatg gtggctcagc aattgtacaa cctgtctaaa acacttttct tattaggcgt 736981 caaagccgta ttttcaggaa ttcgcccgga tgtggcccaa acatcgattc aattggggct 737041 tgattttagt gaatatgaaa cgtacggcac gctgaagcag gcattagaaa acatgggtgt 737101 ccgctgtatt gttgaggaat tggaagaaaa caaataggaa gtttccaggc atatgattgt 737161 ccgtcaccgg gtgatcatat gcctttttga tttgaacaga aatcaccatt gatttatcga 737221 aaaaaacata atattataat tcttataaga atactgtgaa ttaaaaccta ttcaacaggg 737281 gggaaggtct tttggtttct aaatcaacga ttgatccgga agtgattgaa aaaatcatca 737341 gctcgctgga aacactcgat ttcggcacgg ttcagattac ggttcatgat tctcagatta 737401 cccaaattga gaaaatagaa aagcaccgtt tttcgctgaa aaggaaagaa tcaaaatgat 737461 aatgtaaagg gcgtttgttt tcattaaatt ctccttaaaa catatacata tttcatccaa 737521 tttttatata atagaccttt aagatcattt tttaggagga tttttgacat gcaagctacg 737581 gttcacgaga gtaagcaatc gatcatgcaa cgcattttga cagtctttgt cttcacattg 737641 ctgatcgcga ctgtcggcct ttttatcggc caatttgttc ctgtcgcttt gatgctgccg 737701 ctttctattc ttgaagtggc gatgattatt ctggccttct ggatgcgcag aagaaaagcg 737761 gtcgggtatg cgtttgtata tacattcgcg ttcgtttccg gcattacctt atttccgatc 737821 gtcagccatt acgcttccat cgccggcgcc tatgtcgtgc tcgaagcctt tggctctaca 737881 tttgtcattt ttgccgtctt gggcacaatc ggcgcaaaaa tgaagaagga tttatccttc 737941 ctgtggtcgt ttctgctggt tgcggtgctc gcactcgcag tggtagggat tttcaacatt 738001 ttcagcccgt taaactcagc ggcgatgatg gcgtattccg tgatcggaac catcgtcttt 738061 tccctttaca ttttgtatga tttgaaccaa atcaagcacc gccacattac ggaagacttg 738121 attccggtta tggcgttatc gctgtaccta gactttatca acttgttcat caacctgctc 738181 cgcttcttcg gcattttgag cagtgatgat taatgaaaaa gcgtctgtca ttggataggc 738241 gctttttgcc atacatcaaa aaggcaggtg gagtattggt gaaaaaacaa atgggcgcat 738301 atgtatctct ggcagcagct atggcgatcg tcggcagttc tgtcgttgtc ggcaagctga 738361 tggtcgaacg gattccggtc tttctttcct caggattgcg ttttttgatc gcttctgtcg 738421 tattgctcat gctgctgttt tgcattgaaa aagggtttcc ggctttgacg aaaaaagatg 738481 tgttcgtatt actggtgcaa tcattcacag gcgtgttttt gttcagtatt tgcctgctgt 738541 atggggttca atatacgacg ggaacggaaa gcggcatttt gacaagcaca acccccatgt 738601 tgatcggtat tttatccttt ttcctgctga gagaaaaaat tgagaaaaag acgctgatcg 738661 gcattttgct ggcggtttgc ggcgtaatgg cgattaattt gtttggagcc gggagccaag 738721 acgggacgcc gcacgcctta ttcgggaaca tgctgatcat tgctgcagtc attggcgaag 738781 cgttgtttac attgatggcc aagctgctat ccccgcatat ttcggcactg gcgatttcga 738841 ccttcgtatc gctcttcggc ttcctgtttt ttctcccgtt tgctttgttt gaggcctctt 738901 catttgatta cagcgtgccg actgttttgg attggtcgta tgtgctgtat tacgcgcttt 738961 ttgtcactgt tttggcgttt tacttatggt atagcggggt gacgaaggtg ccggcgggtg 739021 tatcgggcat tttcacatcc gttcttccgg tctcagctgt cattttgtca ggcgtgatat 739081 tgaaggagcc atttgagttt gtgcatttca tcggcattgc atgtgtcatc ggcggcatat 739141 ttgttacggt cataaagaaa aaacagccgg atgcgtatcc ggctgcagaa gaaaagacgc 739201 tatagcctgt ccggatcgga cgggtttttt agtctttaaa cacgctcagc ctttcaaaaa 739261 gatcaccaag catcttcacg aacatgtctt tttcctcgtc gctgtagttt tccatgacag 739321 cggatatttt gctgaaatgg ccgggcagaa attgctccag gcgtgctttg ccttctgttg 739381 tcagttcaat gctgattttt cgtttatcct ctgtgtgatg cctgcggctg acaaaaccgt 739441 ctctcgccag cccgtctagc aggcctgtaa ttgttgcttt cgtgacattt gaccgcttgg 739501 caagctctgt cggacttaac ctatgatcct tggcatcaaa gagcagcatc aggattttga 739561 attttccttc tgaaagccct cggccagcaa agtaatgctc catcacatga ttcatttttt 739621 ttgaaatatc aaaaagagat aaaaacaatt caagagagcc ggcgtcaata ttggcatacg 739681 tttcggcgtg ctctgttata tgcttatatt tcggtaaatg ttttaattcc atcgcaatta 739741 gctcccgtac attcgttgtg acacgattat aaaggaggga aaaccataac gcaacttggc 739801 ttggagatga ttgacagctt ttcttgggac atagtaaggt aatatagtta ggcgcctaac 739861 taatacatat agagctgaaa aggtggttat tgatatgaaa catatgttaa tagcaggagg 739921 cggaatcggc ggcttgtcag cggccatttc tctccgtaag gcagggtttt ccgtcacctt 739981 atgtgaagcg gcttcagaaa atcgaaaaac aggtgcgggg attcttcagc cgcaaaacgc 740041 actggcggtg ttgaaagaac tgggcgtatt cgaagattgc tgtaagcacg gctttcaaac 740101 agaatggttt aaaacgtttg atgaacaggg gaatttgctg tttcaagtca gtgaatcctt 740161 tttagacgat tcacttccgg gacgcaataa tatcctgcgc aaaacgttaa atgacattct 740221 catgaagcat gccgaggcag tgggtgtaga catcaagtgg gggaaaaagg ttgtcgccta 740281 tgaagaaact gctgaatcgg tcactgcctt atgtgaagat ggagaaaaga tgcaggctga 740341 cattctggcg ggctttgacg gcattcactc cgttgttcgt gataagatgc tgcaaaagga 740401 aacggaaaaa gagcatctcg gcatgggagc gtggcgcttt tatatcgaac ttcctgatta 740461 cacattcgag gacgcaacat tcatgtatag aagcggagac acacaaatcg gggtggtgcc 740521 attggcacaa cacgctggct atgtcttcgt cctccagcct tgcacgagcg attactggga 740581 tgaggaagat acccggtttg atagagtaaa agagattctt tctggttttc gggggctgga 740641 ttttgtcaca aagcacatgt caaaacagca tcctgtcatc tttaacaaac tggagcaggt 740701 cgccgtgcag gagccatggc ataaaggccg cgtcatcatc ggaggagacg ccgcccacgc 740761 cggtgcgcca accctggcac aaggagcggc aatggcgatc gaggatgcca tcgtcctcgc 740821 cgaagaactc caaaaccacg ccgaccacga aacagcatta caggcgtact ataaaagaag 740881 agccccacga gcgctcaaag tccagaacct atcatctgaa atcgtccgcc gcaggctgaa 740941 aggagagccg ggagcggaag aactgattgg ggagtgctat gcggtgttga gggaagggta 741001 ttaaatagga aaagtccaga aagtgatttc tggacttttt agtcttgctc tgttttattc 741061 cttatccgct caatcacctc atgcagcccc tcaggcttat aaaactccac cggtgaactg 741121 cctttctcaa acgaaatcgt ctcggcttca atcagcgcga catagcgccc gtttactttt 741181 gcgagatgaa tagaatcgcc aaaatccgct agcaatccct taatctctgt ttctccgact 741241 ttcattttca gctgggcctc tggcgtgtgc tcgatgattt gggcggaggc ttcgatgact 741301 tgatgggtgt cgaggcgctc ttggatttcc cgtttttcgc ttgcttccca aatctcaatg 741361 tcgtgctcga actgcttgag ttcttcgctg ttgtcttcaa atgtctcgta gacgtgctct 741421 tgtaccatgt tcatgacctg atttttcatg atttctggca tcgattctcc gtactcgacg 741481 aatttcagaa agtcctcaaa atagcgggcg tgcgaggcct ggtggatttt cagttcacct 741541 tcctcgacca ttccttcctc tggcatgtac gggtattgga tgcttttcat gttttttgtc 741601 gtgatcgcca tttcgacttt tttaatgaga gaagacgcgt cagagatgcg ggcgaccttc 741661 ggctcaaaat cacatttcat aatgaagaca aatgactcat caaagtattt tctcggcacg 741721 gccgaagcga cgagaaacac gccgccgcga accgcgcttg tgtcaaggta cgtgcggacg 741781 aactgctcgc tcagctcatt gaagtcttct tttgtttccg ccagacgcgc gcggttgaac 741841 atgttgtagt ttgggttgga atcgagctcg tggccgggct cgacgataaa atggccgatt 741901 ttcgtcggca cctgctcgga ctgcggatgg cggtcggctt tccgtttaac gatttttttc 741961 agttccccgt cgagaaagtc cttcagctcg ctttcttcaa attctcccgt atcaagggtc 742021 tggaagtgct tgaactgctt gttcgcctgc tcatctttgc cttccacctg tatgacataa 742081 aaggataaaa accgaatttc aaaatccata tataaactca ccttattcgc gtattgtaca 742141 gcttctcaag tatagaaaaa acagcgatca tgcgtcaatt gggagaacgg aataatcatg 742201 accatgaaag ggaaatgtag tcaaatagaa ggcatttcat acggaaagga atggttcgat 742261 gaaggaaaca agcccgattc ctcagccgaa gacgtttggg ccgctcggca atttgccttt 742321 aattgataaa gacaaaccga cgctttcgct gatcaaactg gcggaagaac agggcccgat 742381 ttttcaaatc catacacccg cgggcacgac cattgtagtg tccggccatg aattggtgaa 742441 agaggtttgt gatgaagaac ggtttgataa aagcattgaa ggcgccttgg aaaaggttcg 742501 cgcattttcc ggtgacggat tgtttacgag ctggacgcat gagcctaact ggagaaaagc 742561 gcacaacatt ctgatgccga cgttcagcca gcgggccatg aaggactatc atgagaaaat 742621 ggtcgatatc gctgttcagc tcattcaaaa atgggcaagg ctcaacccga atgaagcagt 742681 cgatgtcccg ggagatatga cccggctgac gctcgacacc attgggctat gcgggtttaa 742741 ctaccgcttt aacagttact acagagaaac gccccacccg tttatcaaca gcatggtgcg 742801 ggcgcttgat gaagcgatgc atcaaatgca gcggcttgat gttcaagata agcttatggt 742861 cagaacaaag cggcaattcc gctatgatat tcaaacgatg ttttcgttag tcgacagcat 742921 tattgcagag cgcagggcga atggagacca ggatgaaaaa gatttgctcg cccgcatgct 742981 gaatgtggaa gatccggaaa ctggtgaaaa gctcgacgac gaaaatatcc gctttcagat 743041 catcacgttt ttgattgccg gccatgaaac aacgagcggc ctgctttcct ttgcgactta 743101 ctttttattg aagcatcctg acaaactgaa aaaggcgtat gaagaggtcg atcgggtgct 743161 gacggatgca gcgccgacct ataaacaagt gctggagctt acatacatac ggatgatttt 743221 aaatgaatca ctgcgcttat ggccgacagc tccggctttc agcctttatc caaaagaaga 743281 cacagtcatt ggcggaaaat ttccgatcac gacgaatgac agaatttctg tgctgattcc 743341 gcagcttcat cgtgatcgag acgcttgggg aaaggacgca gaagaattcc ggccggaacg 743401 gtttgagcat caggaccaag tgcctcatca tgcgtacaaa ccattcggaa atggacaacg 743461 ggcctgtatc ggcatgcagt ttgcccttca tgaagccaca cttgtgttag gcatgattct 743521 aaaatatttc acattgattg atcatgagaa ttatgagctt gatatcaaac aaaccttaac 743581 acttaagccg ggcgattttc acatcagtgt tcaaagccgt catcaggaag ccattcatgc 743641 agacgtccag gcagctgaaa aagccgcgcc tgatgagcaa aaggagaaaa cggaagcaaa 743701 gggtgcatcg gtcatcggtc ttaacaaccg cccgcttctc gtgctgtacg gctcagatac 743761 cggcaccgca gaaggcgtcg cccgggagct tgctgatact gccagtcttc acggcgtaag 743821 gacaaagaca gcacctctga acgaccggat tggaaagctg ccgaaagagg gagcggttgt 743881 cattgtgacc tcgtcttata atggaaagcc gccaagcaat gccggacaat tcgtgcagtg 743941 gcttcaagaa atcaaaccgg gtgagcttga gggcgtccat tacgcggtat ttggctgcgg 744001 cgaccacaac tgggcgagca cgtatcaata cgtgccgaga ttcattgatg agcagcttgc 744061 ggagaaaggc gcgactcggt tttctgcgcg cggggaaggg gatgtgagcg gtgattttga 744121 agggcagctt gacgagtgga aaaaaagcat gtgggcggat gccatcaaag cattcggact 744181 tgagcttaat gaaaacgctg ataaggaacg aagcacgctg agccttcagt ttgtcagagg 744241 gctgggcgag tctccgctcg ctagatcgta cgaagcctct cacgcatcca ttgccgaaaa 744301 tcgtgaactc cagtccgcag acagcgatcg aagcactcgc catatcgaaa ttgcattgcc 744361 gccggatgtt gaatatcaag agggcgacca tcttggcgta ttgccaaaaa acagccaaac 744421 caatgtcagc cggattcttc acagattcgg tctgaaggga accgaccaag tgacattgtc 744481 ggcaagcggc cgcagtgcgg ggcatctgcc attgggccgt cctgtcagcc tgcatgatct 744541 tctcagctac agcgtcgagg tgcaggaagc agccacaaga gcgcaaatac gtgaactggc 744601 gtcatttaca gtgtgtccgc cgcataggcg cgaattagaa gaactgtcag cagagggtgt 744661 ttatcaggag caaatattga aaaaacgaat ttccatgctg gatctgcttg aaaagtatga 744721 agcgtgtgac atgccgtttg aacgattttt agagctttta cggccgttaa aaccgagata 744781 ctattcgatt tcaagctctc caagagtgaa tccgcggcaa gcatcgatca cagtcggtgt 744841 cgtgcgcggc ccggcgtgga gcggccgtgg cgaatacagg ggtgtggcat caaatgattt 744901 agctgagcgt caagccggtg atgatgtcgt gatgtttatc cgcacaccgg aatcccggtt 744961 tcagcttccg aaagaccctg aaacgccaat tattatggtc gggccaggca cgggagtcgc 745021 gccatttcgc ggtttccttc aagcccgcga tgttttaaag cgggagggca aaacgctcgg 745081 tgaggctcat ctctattttg gatgcaggaa cgatcgggat tttatttacc gagatgagct 745141 tgagcggttt gaaaaagacg gaatcgtcac tgtccacaca gccttttccc gaaaagaggg 745201 catgccgaaa acatatgtcc agcatctcat ggctgaccaa gcagatacat taatatcaat 745261 ccttgaccgc ggtggcaggc tttatgtatg cggtgatggc agcaaaatgg ccccggatgt 745321 ggaggcggca cttcaaaaag cgtatcaggc tgtccatgga accggggaac aagaagcgca 745381 aaactggctg agacatctgc aggataccgg tatgtacgct aaggatgtct gggcagggat 745441 atagataaag aagactggag acatccagtc tttttagtcc tttcgaaaaa atggtgatcg 745501 cgctaaacat tgatgcatac aataacttca gtccgccgga agggcgggct gtctgcaaaa 745561 cctatttttc gtttttgcta gtttatgtta ttcttatact cggtatctat ttcttttttc 745621 aaaggcacac atgacaaaag aaatcctttt tttatttccg agaaaaaaat gtgaaacgaa 745681 atgaaggttt ctttcgtcca gtgattggtt tccaaatggt tgtaataaaa atgatatggt 745741 gcgaaacata aatattccgg cttgccgcgg tgtatttatt gttgtgtgat gccttgattt 745801 tgtttggaaa gaaggaattg gaaggcagga tataaagagc aggtaaatat gaatgaagaa 745861 cttaaagtgt ttaagaaagt agaggttgcc atgaagaaac ttttttctta caaacttagc 745921 ttttttgtgc tggctgttat actgttttgg gcaaaaacgt atttatccta caagactgag 745981 tttaatcttg gggtaaaagg cacaactcag gagatcctcc tgatatttaa cccattctca 746041 agcgccgtct tctttttagg actggctttg ctggcgaaag ggcgtaaatc agccattatt 746101 atgctgatta tcgatttctt gatgacattt gtgttatatg caaatatttt attctatcgt 746161 ttctttgacg atttcttgac gttcccgaac attaaacagt ccggaaacgt tggaaacatg 746221 ggagacggga ttttcagtat catggccggt catgatattt tctatttctt agatattatc 746281 attttgattg cggtattgat ctggagacct gaattaaaag aatacaaaat gaaaaaacgc 746341 tttgcatctt tagtgatcct ttctgggatc gcactgtttt tcatcaacct gcactatgcg 746401 gaaaaagacc gtccgcaact gctgacaaga acgtttgacc gcaattatat tgtgaaatat 746461 ttaggtttat acaactacac catttatgac ggtgtacaga cggctcaaac agagacgcaa 746521 agagcctatg caagcagcga tgatttaaca agtgtcgaga attacacgac gtctcattat 746581 gcgaaaccaa acgccgagta cttcggctct gccaaaggca aaaatatcat taaaattcac 746641 ctcgaaagct tccagtcatt cctgattgac tacaagctaa acggtgaaga ggtgacgcct 746701 ttcttaaata aacttgcgca cggcggggaa gatgtgacgt attttgataa cttcttccat 746761 cagacaggcc agggaaaaac atctgatgcc gagctgacaa tggataactc gatcttcggt 746821 cttcctgaag gctccgcgtt tgtgacgaaa ggcgaaaaca cctaccagtc gcttcctgcg 746881 attttagacc agaaggaagg ctatacaagc gccgtcctgc atggtgatta caaatcgttc 746941 tggaaccgtg accagattta caaacatatc ggatatgaca agttcttcga cgcaagcacg 747001 tatgatatgt cagatgaaaa tgtgattaat atggggctta aggataagcc gttctttaca 747061 gaatcgattc caaagcttga atctcttaaa cagccatttt atgcgcattt gattacattg 747121 acaaaccatt atccgtttaa ccttgatgaa aaagacgcgt ctcttaaaaa agcgacaaca 747181 ggcgataaca cagttgacag ctacttccag acagcgcgtt accttgacga agcgcttgag 747241 caattcttca aggagctgaa ggaagccggc ctgtatgaca actcagtcat catgatttac 747301 ggtgaccata acggtatttc tgaaaaccat aaccgagcga tgaaagagat tcttggaaaa 747361 gagatcacag attatcaaaa cgcacagaac cagcgtgtgc cgctgatgat ccgcgttcct 747421 ggcaaaaaag gcggagtgaa ccatacgtat ggcggcgaaa ttgacgtcat gccgacactt 747481 ctgcacttag aaggaattga ttctcagaaa tatatcaact ttggtactga tttattctct 747541 aaagaccacg acgatacggt ggcattcaga aacggagact tcgtaacgcc gaagtacaca 747601 tcagtcgaca atatcattta cgatacgaag acaggtgaaa aactgaaagc gaatgaagaa 747661 acgaagaatc tgaaaacaag agtgaaccag cagctgagcc tttcagacag tgtcctgtac 747721 aaagacttgc tgaggttcca taaactaaat gatttcaaag ccgttgatcc gtcagactat 747781 cattacggca aggagaaaga aatcaaataa gatgaaaaag agccttgagc gggcgcattg 747841 ccttcgctca aggctctttt tttggttata caaccaactt gaaaaaatag attccatttg 747901 gtcaccaagg ctggctttct ctcatatcat tacagtagat tttgaaaccg gattgaaatc 747961 ggacaaatta tcggggaaat gccttgatag attgtgaaga tgtaccaggt ttcgaactca 748021 atattcatag agatgagggg tagagatgaa agcggtcatt ctctgcggcg gaaaaggaac 748081 gagaatgagt gaagtcacga atgacattcc taaaccgctc gccatgatag gcggcaaacc 748141 gattctatgg catattatga aaatttatca gtactacgga gtaaacgagt ttattctgct 748201 tttgggctat aaaggagaaa aaatcaagga atactttctc gactatgaat ggaagcacaa 748261 cagcctgaca ctcgacagct ctacgggaga ggtacagatg ctggggcagc ctgaaacgtg 748321 gaaaattacg tttttggaga ctggggtaga tacgctgaca gccggaagaa tcttgcaggc 748381 gaaagactat atcggtgatg aaacatttct gctcacctat ggagacgggc tggccaatat 748441 caatcttttc catctcatca gctatcatca gacaaaaggt gctgccgcga ctgtcaccgg 748501 cattgacaaa gtctcgcagt ttggcacctt gacagttgag gatggcatgg cgaaaacatt 748561 ttctgagaag acatcaagtg atggaatcat caacggcgga ttcttcgttc ttagtccaaa 748621 ggttttcgat tatttgccga aggacgggaa cacgatgttc gaagatgaac cgctgaagaa 748681 ccttgccaaa gatggggagc ttgctgtgta ccgccattac ggattttgga cggccatcga 748741 tacgtataaa aatctcttag aagtcaacaa aatgtggaat caaggacaac aagtatggaa 748801 ggtatggtga attgatttga gtttctggaa aaataaaaac gtatttgtca cgggatgcac 748861 aggtctttta ggaagctatt tggtgaaaga gctgatcgaa cagggcgcaa acgttacggg 748921 gctagtcagg gatcatgtgc ctcaatccaa tctttatcag ggagaacata tcaagaaaat 748981 gaacatcgtg cggggctctc ttgaggactt ggctgtgatt gaacgcgcgc ttggcgagta 749041 tgagatcgac acagtctttc atcttgctgc acaagcgatt gtcggcgtgg caaaccgcaa 749101 cccgatttct acctttgaag cgaatatcct cggcacctgg aatattctcg aagcctgccg 749161 caagcatccg ttaattaagc gggtcattgt cgcttcaagt gataaagctt acggcgatca 749221 agaaaacctt ccatacgatg aaaacatgcc gctgcaaggc aagcacccgt acgacgtctc 749281 aaaaagctgc gcagatctga tcagccacac ctattttcac acgtacgggc ttccggtctg 749341 cattacgcgc tgcggaaact tatacggcgg cggagatttg aacttcaacc gcatcattcc 749401 tcagacgatt cagcttgtgc tgaacgggga agcgccggaa atccgaagcg acggcacatt 749461 tgtacgggac tacttctata ttgaagacgc cgttcaggct tatctgcttc ttgcagaaaa 749521 aatggaagaa aacaatcttg ccggagaggc ctttaacttc agcaatgaga tccagctgac 749581 cgtacttgaa ctggtagaga aaatattaaa gaaaatgaac agtaatctga aacctaaggt 749641 gctgaatcag ggaagcaatg aaatcaaaca tcaatattta tccgcggaaa aagcaagaaa 749701 gctgctgaat tggacaccgg cctacactat tgatgaggga cttgaaaaaa cgattgagtg 749761 gtatacggaa ttcttcaaaa agtaatgtga aacgaggtga acaagactgt gaccagcgcg 749821 tattgcaccg ttttatcaaa aggaagatta tatcaggcag tcgctttgtt taagtcgtta 749881 gagcaagttg atcaagacag tcccattttt atactttgca tggatgaaga tacgcaccgc 749941 gtgttacaga agctgaagat gaagcagctg aaccttgtgc cggtggccgc tcttgaaaat 750001 gaattgctgc tgaagctgaa ggaaactaga gatcaaagtg agtattgctg gacgatgaag 750061 ccgatctttc tgcaagctgt gctgaacagc aatcctgagc tggagcgtgt gacgtatatt 750121 gacggggatc tctttttcta tgcagatcca tcgccgattt ttgaaaacca gccggactgc 750181 tcggtgttgc tttcacgagg ggatattgta atcccttctt ttgagaaaga gcagattgac 750241 atgctgcagc gtcttttagg cagatataat tccgggttta tcagcttcaa gcatgatgat 750301 gcaggcacgg attgcttgga gtggtggaag gaacgctgtc ttgaggaatg caaaaatgca 750361 ccgggtgaag ggaaattcgg tgatcagggc tatttggatt atatgtctga gctgtttccg 750421 aatgtgtgtg acattacaac acccggcgtg aacatcggcc attggaatta tggacagcat 750481 acgttttcct ggaaagatgg ccggatcgtg ctggaggatg gcagtccgct gatcttttat 750541 catttcagcg gataccgaat cgtcagcatc aatgaaatca aacagattca tgaaacaacc 750601 cgcacagatc tgccgtttgt gcatgaactg tatcaagaga cactgccgca tatcattcag 750661 cacatgcaaa cgttagaccc tgaatttaac ggttttgctt caaaagatga caacaaataa 750721 atgagtaaat acaggaagtg aaaatgaagt gaaagcaagc gttattattc ctgcatataa 750781 ttcgaaggag cgtctttaca acagccttct gtcattaaac cagcaggagt gcgatgaaga 750841 atttgaagtc attgtagcgg acaatggctc tgaggacggg acgctctcga tgcttgagtc 750901 atttcaagct gattttccgc tgatctttac acggattaaa gaaaacaggg gcattgcgta 750961 cggacgaaat caggcgcttc gcaatgccag aggagacatc ctgattttcc atgacagcga 751021 tatgcttgcg gcaaaggacc ttgtggcaaa acatattaaa gcccatgaga acgaagagaa 751081 tctcgtcgtg tgcgggttgt tttggaaacg gatctacagt ttttactatg aacgatttga 751141 agaagaacat aaggaacagc tcgcaaagct cacaggtgaa atgccgaaga aagacaaaca 751201 aaagctgctg gaggaagcgg acatcaaaaa cggaagcttt cttgataaaa gctttgacct 751261 cgataccgac tttatagacg tgctcaagaa gattttagat gagtacggcg atgacttgaa 751321 aggctatcat atgccatggc gcttttttat cacgaataat tcctctgtga aacgcaagca 751381 tgtggttgac ctcggtttat ttgacgaagg cattgtgcgg tacgggtttg aggattatga 751441 cctcgggatc aggcttcatc aggccggatt gaccttcagg cttcgccgtg atattgtcag 751501 tgttcatcag gaacatccaa gcaattgtaa gtctgtagac gatattcggg caaacattgc 751561 ctatatgtgc gataaataca ataacatccg ctccttagac gttcatctcg cttttaatgg 751621 gccgttcccg cctgacatga cgaacagaat catggctgat attcaaaagc tgctggaatc 751681 acagaaatat gatatgctgc tgaatctgtt tcttgagctt ctgcatgttg ttaaagagcg 751741 caacattgat ccggattggc gaaagaaatc cccaagggtg acggcgaaaa gctttgattt 751801 gcaaactgtc cgcaagcttc tgcctaaggc gaagaaaaag ctaggcgtga acgattttgc 751861 caacgcactg tatgcgcttg tcaacgattt gctgcacgtg gatcttagat cattggatgt 751921 ggtataagtg agtacatttc atttttcaac gatagtgtca aggacacata tctttaagct 751981 catgcctatg attcattctc tccatgagca ttgcgatgat tttcatttat atgtgctgtg 752041 tgtcgaccag aaagcgtatg aattgcttca gcacgttcca tgggagcatg taacctttgt 752101 gcagctgcat gaaatggaag acccggagct gttgaaagcg aaaagcaaca gaacgtttca 752161 tgaatattgc tggacgttaa agcccgcctt tttgtttcat gtgatgagca agtgggatga 752221 cgctgaatac tttgcccata tggatacgga tctatttttc ttttctgatc cggcacgtat 752281 ttttgcagaa aacccaacgg cgtctctgta tttgactgat catcgtaatt cgccgcgctt 752341 catgtcctac tacgaccgaa ccggacgctt taatacaggc tttgtcggcg ccggtaatac 752401 aaaggaagca tatgaagcgg tgtggcagtg gagacaggac tgtattgaat tttgcacggt 752461 cgaaatggat acggaacgaa agacatatgg tgatcaaaga tatgtggaga aatggccgga 752521 gcagtttaaa ggtgttcatg ttgtcaaatc cataggagcc aatacagcgc tttggaatat 752581 cgaaaactat aaggtcgggc aaaaggacgg ccgcgtgtat atagatgaaa cgccgctgat 752641 tttctatcat ttctctgggt ttacgctggt gacagaaaaa gagtttaatc tttgctggta 752701 ctaccggatt gaagacgaag cgacaattaa gatgatttat atgccctata tattaaatct 752761 gaaaagatgg attgatgaaa tacagtcggc gtttccggac tttgcggatg gctttatccc 752821 gaagcacgca gtgcctgaca ctcattttat ccagctggat taaaaaaccc cctgccgcct 752881 ggcaggggtt ttttcagcta tgccattctc tcagcttctg gtcacttggc aataggaagg 752941 caaggatgcc gaggacaggg agaaaggcaa tggcgatcat cgtcggggtc agtcccgcgg 753001 catcaatcag agcgcccagc gccacagcgc cgattgcgcc catcccgaag gcaagcccga 753061 cggttaaacc ggacattgtg ccgatttttc caggaactag ctcctgtgcg tagacgaccg 753121 ttacagaaaa gctcgacatc agaaccaagc caatcaatgc gagcacgccg taggcgagaa 753181 ccgggccggc aaatggcagc acaatcgcca gcggcgccga gcataacagc gaaccgagga 753241 taacgaagcg ttttccaaaa cggtctgcaa gcgggccgcc gagaaacgtg ccgatcgcgc 753301 cgaacagcaa gaagacaaaa atatagcttt gtgcctgctg aatgcttacg tgataggtat 753361 ccatcgcgta aaacgtgtaa aagttaccga tcgcactcgt ataccaagaa cgagcaaaaa 753421 tgagaaatat aataataata agagcagata caacagattt ggtgatggcc gtgttttcag 753481 ccgttttctt ttgcttgcct gatttctggg caaggctgcc gagacgtgag gcgtaccatt 753541 tcgcaatata catgagaaac ataacagcaa gcgcggcgac aagcgtgaac caaacagcgc 753601 cgaattgccc gagcggcaca aggatcagcg cggtgatcag cggtgccatc gcctggcctg 753661 agtttccgcc cacctgataa atcgattggg cgagcccgcg ttttgtgccg gcggccatat 753721 acgccacacg ggagccctcc ggatggaaaa tggccgagcc taatccaatg aaaaacacac 753781 agcataagat cgttatgaat gacggggcaa atgcaaggcc caaaatgcca agcatgctgg 753841 cggtcaaacc gactggcagc gcatacggcc gcggccgttt atcggtatac cagccgacaa 753901 caggctgcat gacggatgac accatgttta atgtgaaagc aatgatgccg agctgtgtaa 753961 acgtcaggct catggagcgt tccaaaatag ggaacatggc cggaatcaca gcctgaagcg 754021 aatcgttgag catatggcaa attccgataa taatcaaaat cggatacacc gtggtgcctg 754081 gtttttgaac tgttttttct tttaacgggg cggcgatagc cattgagtct cctccttaca 754141 tatataacca aagcatacca ccatattatt cataaggtga agaatttatc aagaggaaaa 754201 aagattctta tgaaagaaat accgtcagcc tgattagcag ctgacggtat tttcgatatt 754261 caaaatgtga tatagctctt caagcttacg aatctcatag gttggtatga tctctggcac 754321 attcggcttc atgtcagggt tcatccagca agtatcaagc ccggcgagct gtccgccttt 754381 gatatcagca gttagtgaat ccccgatgat taatgtgtgc tctgctgaaa attgaggaat 754441 ccgttcaaac acgtaattga aatattcctt catcggcttt tggaagccgg tgtcttcaga 754501 aacgaaaatg tccttgaaga atggaaataa tcctgaatca cggagacgct tatattgtgt 754561 gtgagacacg ccgtttgtca cgatgtacaa atcaaactgt tgctgcagat ttgagatgag 754621 atcaaatgca ccgtcaataa gctgatgtcc ttcttcaaga aagcggcggt atttttgctc 754681 aagcaaagcg ccgtccgctt cgtaaccgta ctccttgagc aaagcggaaa aacgtgtgtt 754741 tacgacttca tcccgtgtca tcttaccttc ttcaaaggct ctccagagac cttgattgat 754801 ggttttatac tgcgccttca tgtcatttgt taaaggaatg ttctgatctt caaacagcaa 754861 acgcagggct aaagcttctg ccgcttgaaa atcaaggatg gtatcatcta catcaaataa 754921 taaagtgcgg tatcgcttca tctgtgtgtc tccctttctc atatgtattc aaagtatagc 754981 acataaaaaa aggaaaaagc cggcgggtga ggcaccgccg gctgaaaaga gattatttgt 755041 ttaataagct gtgttttctc gaatatagga agtaaaccag cgttccgaca gcgatccaga 755101 tgacaaatga aagccatgtg acgccgggaa ggctgtacat gaaccaaagg cagatgcctg 755161 cgctgataat cggcacaacc ggaacgaatg gcactctgaa ggacgctttg atttcaggat 755221 gtttctttct taacacaatg acagcaatgg aaatgaccgt aaacgcggca agtgttccca 755281 tgttcaccag atgggccagc gttccgaggt taataaagcc ggcgattccc gctgcaacga 755341 tccctgtcag ccatgtgttg cggaacgggg ttttaaatga cggatgaacc tttgcgaaca 755401 atccaggcag aaggccgtct ctgctcatgg caaatgtcaa gcggacctgt gcgtacagca 755461 aagcgagcat caccgtcgta atcccgataa tcgcaccgac agaaataatt ccggcaacag 755521 cgtcctgtcc gacgaatttc agcgcaaagg atacaggatc tccgacattc aatttggcat 755581 aaggcatcat gcctgtcagc acaagcgata ccgcgatgta cagaaccgta cagacggcta 755641 gagctgaaat aatgccgacg ggcatgtttt tttgcggatt tttcacttcc tctgatgcgt 755701 tagaaaccgc gtcaaaccca aggtacgcga agaatacagt ggcagcgcta agtatgacgc 755761 ctttcatccc gaatggcata aaaggagacc agttatccgg tttcacatag ccgatgccga 755821 caataatgaa caataatatg atcgcgattt tcatcagtac gatgacgttg ttaaagcgtg 755881 tgctttcctt gacgcctctg ctgacaatcg cagtgatgag gagaatgatc accgcagccg 755941 gaaggttaaa tacggcgccc gccatgcttc ccggcgctcc tgtcagtgca gccggaatat 756001 gaagattgaa gccggcaagc agtgattgaa agtatgaaga ccagccggtg gcaaccgccg 756061 acagtgcaat gacatattca agcatgagat cccatccgat caaaaaggcg agcagctctc 756121 caagtgtcac gtatgagtat gagtacacgc ttcccgaaat cggaatggaa gacgaaaact 756181 cagcataaca gaaagcagcc agcgcacagg cgagccccgc taaaataaac gatatgatga 756241 gggcgggacc tgcaccggtc gctgccactg ttcctgtaat gacaaaaatc cctgtaccga 756301 tgacacaacc gataccgagc aaggttaaat caaatgcgct taacgtacgg gcaaggcttt 756361 ttgacttgct ctgcgcactc aatgtttcaa gcggtttttt tctaaataat gaactcatca 756421 aaagttcctc ctagaaatat tcaaaatatt ctaatcatta tatgcagttc ttgttgtatt 756481 atattgtcga aatttgacgt agtcaataaa atatttttct gctttaaatg atagaagcga 756541 aacagcgttg tcgtatcata ggatagtaat ttttactaat cgtatattca attttatgca 756601 agatgaaccg atagaaaaaa tagattcgcc catattttga tttgcggtta taaaggagat 756661 gctgaccatg tttcaatatg aagagttgaa taaacagttt atcggcggga aatggcagga 756721 gggcagcagc ccaaatgtat tggaaaacaa aaatccttat actcaaaaaa cattcacaac 756781 attccgtaaa gcgactgctg acgatgtaga tgaagcgtat cgggcagcgg cgctggcaaa 756841 gaaaaaatgg gatgcggtca acccgttcga gaaaagaacc attttagaaa aagccgtcac 756901 gtatattgaa gaaaatgaag aagccattat ttatttgatt atggaggagc taggcggtac 756961 aaggctcaaa gcagcttttg aaatcggtct tgtcaaaaac atcataaaag aagcggcaac 757021 gttcccaatc cgcatggagg ggaaaattct tccgtcaaca atagatggca aggaaaacag 757081 attatatcgc gtgccggcag gcgttgtcgg tgtcatcagt ccgtttaact tcccattctt 757141 tttatctatg aaatcagtgg cgcctgcact cggagccggc aatggcgttg tgctaaagcc 757201 gcatgaggaa acgccgattt gcggcggaac gctgattgcg aaaatttttg agaacgcggg 757261 aattccagcg gggctgctga atgttgttgt cacagacatt gctgaaatcg gcgacagctt 757321 cgttgagcat ccagtgccgc ggatcatctc atttaccggt tctacgaaag tcggcagcta 757381 catcggacag cttgcgatga agcattttaa aaagccgctt cttgagcttg gcgggaacag 757441 cgccttcatc gtacttgagg atgcagatat agaatatgcg gtcaatgcgg cggtgttcag 757501 ccgatttaca catcaagggc agatttgcat gtcagccaac cgcgtgcttg ttcattcttc 757561 tatttatgac aagttccttg agctgtacca ggcaaaagtg gaatcgctga aagtcggcga 757621 cccaatggac cctgatacga ttatcgggcc attaatcaac agcagacaga cggacgggct 757681 gatgaagact gtagagcaag caattgaaga aggcgctgta ccagtgaagc ttggcggatt 757741 taacgggacg atcgtggaac cgacgatctt aaaagacgtc aaaccgttca tgagcattgc 757801 caaggaagag ctgttcggac cagtcgtctc ctttatgaag tttgattcag aagacgaagc 757861 ggtggatatc gcaaacgaaa ccccgtttgg cttgagcggt gccgtacata cgtcaaatct 757921 tgagcgcggc gtggcttttg cgaaacgcat tgaaacaggc atgattcacg tcaatgacac 757981 gaccatcaat gatgaaccga atgtagcctt cggcggtgaa aagcaatcag gcctcggccg 758041 tttaaacggt gagtggagcc tcgaagaatt tacaacgctg aaatggatct cggtccagca 758101 cgaaaaacgc agcttccctt attaatgaaa aggagtgaat ggaattgacc ataaatacgg 758161 aaaaagaaac cgcagatatt ctggacgcat ttatcaaagt agccccttat ttaaacagcc 758221 tggttcagga tgatattaca atcggcattt atgatacgga aaaactgctc gtgaatatac 758281 cggccaaaac cttttcgctg aacgtaaaag ccggcgatcc gctgcaggaa ggggatatca 758341 tcacagatgc catccgcagc aatcagaaga agacgagcat ggttccgaaa gaattgttcg 758401 gcttcccatt gatcgcgcgt gccatcccgc tgcacgacga gaatggaaga gtcattggag 758461 gcgtcggcct cggaacgagc cttgaggagt cgtcaaagct gcatgatgtc gcggaaagct 758521 tatcagctgt tgttgaacaa acagccgcgg ctatttccga catttctgaa tcaattaacg 758581 ggttttcaac tcaaatgtcg ggcatttcct ctcaggcgaa aaaagtaagc gaaagcgccg 758641 gtgaaatcgc cgatatttca gtaactgtta aaggcatctc ggaccaaagc aatctgctcg 758701 gcttgaacgc cgcgatcgaa gcggcaagag caggggagtc cggaaaagga ttctctgtcg 758761 tcgcagatga gatcagaaag ctagcgacgc attcaaaaga aaatgtcggc caaattgacc 758821 agattacgaa aaaaatccac agcctgctga aagggctgga ggaatccatt gagtcgatta 758881 accagcatac agacggacaa gccgctgctg ttgaacaaat ttccgccacg atgcaggaga 758941 tttcaggaag cgcgcagcat cttgcgaaaa tggccgaaaa agcgcttgag gaagagtaag 759001 agaccgggga caaacatccc cggtcttttt cttatcctgc atttccatga aattcgtctg 759061 acgttttact agttttattc cagcggctga tttaaaatgt acacatgaac ttacgtgagg 759121 attgatagga accatgagca tattaaaagc ggaaaatctt tataaaacat acggagataa 759181 aacattattt gaccatatct cctttcatat tgaagagaat gagagaatcg gattaatcgg 759241 gccgaacgga acaggaaaat caacgctgtt gaaagtgatt gccggcttgg aatctatcga 759301 agaaggagaa atcacgaaat ccggaagcgt gcaggtcgaa tttcttcatc aagacccgga 759361 gctgcctgcg gggcaaacag tgctggagca tatctattcc ggtgaatcgg ctgtgatgaa 759421 aaccttgcgt gaatatgaaa aagcgctgta tgaactgggg aaagatcccg aaaatgaaca 759481 gcgccagaaa cacctgctgg cagcacaagc gaaaatggac gcgaacaatg catgggatgc 759541 aaacaccttg gcaaaaaccg tattgtctaa gctgggcgtc aacgacgtaa caaaaccggt 759601 caatgagctc tcaggcggcc agaaaaaacg ggtggccatt gccaaaaact taattcagcc 759661 cgctgatttg ctcattttgg acgagccgac aaaccatttg gataatgaaa cgattgagtg 759721 gcttgaaggg tatttaagcc aatatcccgg cgccgtcatg ctggtgacgc acgatagata 759781 tttcttaaac cgtgtcacca accgcattta tgagcttgaa agaggcagcc tctacactta 759841 caaaggcaac tatgaagtgt ttttagaaaa acgcgcggaa cgggaagcgc aggctgagca 759901 aaaggaaacg aagcggcaaa acctgctgcg ccgcgaactg gcttggctca gacgaggagc 759961 gaaagcccgc tccacaaaac aaaaagcgag aattgaccgg gtagagacgc ttaaagagca 760021 gacaggccct cagtcatcag gttcactcga ttttgccatt ggctcgcacc gtctcggaaa 760081 acaggttatt gaagcggaga acgtcatgat cgcttatgac ggccgcatgc tcgtcgaccg 760141 ttttaatgaa cttgtcatac caggtgaacg gatcgggatc atcgggccga acggcatcgg 760201 gaaaacaacg ctgttaaatg cccttgccgg ccgtcatacg ccggacggag gcgatattac 760261 gatcggacag acggtcagaa tcggctacta tactcaggat catagtgaaa tgaacggtga 760321 gttaaaagtc attgactata taaaagaaac ggcggaggtc gtaaaaacgg cagatggcga 760381 tatgattaca gctgaacaaa tgctcgagcg tttcctcttc ccgcgttcga tgcagcagac 760441 gtatatccgc aagctgtccg gcggggaaaa acgccgttta tacttgcttc aggttctcat 760501 gcaggagccg aatgtcctgt ttctcgatga gccgacgaac gatttggata ctgaaacatt 760561 aagcgttctt gaggattata ttgaccagtt cccaggcgtc gtcatcaccg tatcccatga 760621 ccgctatttc cttgaccgcg tcgtcgaccg tttgattgta tttgaaggaa atggtgtcat 760681 ttcccgcttt caaggctcct atagcgacta tatggaggag tcaaaagcga aaaaagcggc 760741 cccaaaaccg gcagctgagg aaaaaacggc tgaagccgag ccgaagaaaa aacggaaaaa 760801 gctttcttac aaagaccagt tggaatggga cggcatcgaa gataaaattg cccagctgga 760861 agaaaagcat gaacagcttg aagctgacat cgccgcagca ggcagtgatt ttggcaaaat 760921 ccaagagctg atggccgagc aggcgaaaac ggcggaagag cttgaggctg cgatggaccg 760981 ctggacagaa ttgtccctca tgatcgaaga actggaaagc taaaaagcgt ggccgcagca 761041 ggccgcgctt tttttcacat aatggacaaa aacgaaccgg cctgcttatg ttaggataaa 761101 gttgtgtgtc agcggcacat ggaaaactaa cggagatgat gaagtatgac atgggcgatc 761161 gtgatgttaa ttctcatgag tctggtgaaa atcgtattaa cctgtcttcc tacaggcgtc 761221 atagaatggc tgctcggcaa atttgaagtg cacgccaagc tgagtgacga aaatgcgagt 761281 ctctctctag atggaaaacg cctcgagggt gcagagaagc agaaagtgat tgatcaattt 761341 aacgaagcta tcttcctgga aaaatattat atctatccag gtgatgaaga gcgttattta 761401 catccggaaa acggcggcac gcctctggtg atagatacaa aaaaaggaaa aaaagacgtg 761461 aagctgttcg tgtaccgcta cgacgaccat atcgacgtcg tgaaacagta caagaagaaa 761521 gtgatcgcgt atcgagtgct ttctgaaagc cttcaaaaag agtctctgtc agtggcggga 761581 agtttagctt aaacaggaaa gtgaaagacg ggtgctgtat gctgctcgtc ttttttattg 761641 ttttttaaaa cttaacgttt acgttaaggt tcaaaaggtg tataatggta acagaaacgg 761701 cgaaggggga tttaccttgg aatggatgaa gattgatcaa gtggccaaaa gaagcgggct 761761 gacaaagcgg accatccggt tttatgaaga aatcggcttg attccggcgc cgaaacggac 761821 agacggcggt gtaaggcttt attcagagga tgatatggag gagcttgaga aagtcatcag 761881 cacaaaagag gtgctcggtt tttcccttca ggagcttcag catttcatgg aaaccagccg 761941 ccagctagag ttaaacaaag aggggtattt gttgtcactg gatcctaagg aacggaaaga 762001 aaaactggag gaaattcagg aaaccctgaa tcaccagctg gatttgattg atgagaaaat 762061 ccgcacattc caaagcttta aagaacgcct gcagggcatg aaaggcaaag cggaacgcgc 762121 cattcaatca atcgaatgaa aagtttgtta aacgctattt ttgtagcgtt tcttttaatg 762181 gaataaagat ggaggttagg tcaaatggat aagacaacac aagtgaatca gaaaacgggt 762241 ttgctcagcc agccaaaagc ggtatgggct gtcgcgtttg cctgtgtgat ttcttttatg 762301 ggaatcgggc tggtcgatcc aattcttccg gccattgccg cacaattgca tgcttcacct 762361 agtgaagtat cactcttgtt tacaagttat ttgcttgtaa ccggatttat gatgtttttc 762421 tcaggagcca tttccagccg catcggcgcg aaatggacat taattctcgg acttattttt 762481 attattgtgt ttgcggggct tggcggcagc tcaagctcaa tcgctcagtt agtcggctat 762541 cgcggcggct ggggattagg gaatgctttg tttatttcaa cagcgcttgc ggtcatcgtt 762601 ggcgtgtcag tcggcggcag cgcccaagcg attattttgt atgaggccgc gctcggtctc 762661 gggatttctg tcgggccgct tgcaggcgga gagctcggaa gcatttcatg gcgcgcaccg 762721 ttttttggag tatctgtcct gatgtttatt gcgttaatcg cgatttcttt catgcttccg 762781 aagctgccga aaccggcgaa acgcgtcggt gtgtttgatg cgatgaaggc actcaaatat 762841 aaaggcctgc tgacaatggc ggtatcggca ttcctataca actttggatt ttttattttg 762901 ctagcttatt ctccgttcgt actggattta gatgaacacg gtcttggata tgtcttcttc 762961 ggctggggcc ttctgctggc gattacgtca gtctttacgg cgccgctcgt gcacaaagcg 763021 ctgggcacag tgcgttcgct agtcgttctc tttatcgcct ttgcggccat tctcgttatt 763081 atggggatct ggacagacca tcagactttg attattacat gtatcgttgt cgctggtgct 763141 gtcctcggta tggtgaatac gatcatgaca accgctgtga tgggttctgc gccggttgaa 763201 cgttcaatcg cgtcttcagc ctacagctca gtccgcttca tcggcggcgc gctcgccccg 763261 tggattgcag gaatgctgtc agaacacttt actgcaagca caccatatac agtaggcgga 763321 atcgtcgttt ttgtcggcat gcttgtcctt ctcatgggac gtaaacatct tgctggaatt 763381 aaggcggggc attaataacg aaagacactg cgcatatgca gtgtcttttt attcgttata 763441 atgcatcata atcgaattgg tgcaggaaag gacaaccttt atgacacaat tttactattt 763501 tccggctgaa aactcccttt agaaaccggt tttttcggtc agcaagaacg gcgttcgcgg 763561 aaagggcatc cgcttcggtc aggcattgat gcggctggga tttatcttgc agaagctgag 763621 aatgtgtccg ttcatttacg attgccattt cagtgatggt tcatgctgta gaggggacgt 763681 ttgccatgga taaggcaaaa cctgacgaat atgatcagaa atgtttagaa acgctctatc 763741 aatacataca cagcgtcatg aaaaacagct tttctcggtc gagtggttta ccgcttggga 763801 agatgaggag gattttgagc tgtctgccaa aagagagctg acacttgatg aattcacatc 763861 tccattgcag ctcattttaa aagacagaga gcttttgaga atcgttcaga aaaaatggca 763921 gtaaaaaacc cgccctttag caggcgggtt tttttataaa ttaaagcact ttcgtcgtcc 763981 aagactcgca gttccacgtt tctgtcgcaa tatccatata aaagtctggc tcgtgggaaa 764041 tgagcagaat ggagccttta tattctttca gggcgcgctt gagctcttcc ttggcatcgg 764101 catccaagtg gtttgtcggc tcatcgagca ccagcaggtt tgtttctgag ttgattagct 764161 tgcacaatct gactttcgct ttttcgcctc cgcttaatac ggagacgcgg ctttcgatat 764221 gctttgtcgt cagcccgcat tttgccagag cggcacggat ttcatactgc gtataagaag 764281 ggaattcgct ccatacttct tcgatgcacg tattgttgtt tgtttccttg acctcttgct 764341 cgaaatagcc ggtatagatg tgctcaccgc gttcaacaga gccttcgagc ggctggattt 764401 caccaagcaa acttttcagc aatgtcgttt ttccgatccc attcgcgccg taaagggcga 764461 ttttttggcc gcgctccatg cggaggttga gcggacggga cagcggggaa tcgtaaccga 764521 tcacgagatc cttcgtttca aaaatcagct tgcctgacgt tctcgccggc ttaaagtgga 764581 attccggctt tggcttttct gccgcaagct cgatcatatc catcttatcg agtttctttt 764641 ggcgggacat cgccatgttt ctcgtgctga cacgcgcttt gttgcgggcg acgaaatcct 764701 tcagctccgc gacttcctgc tgctgctttt tgtaggccgc ttcaagctgc tgttttttca 764761 cctcgtagac ttccataaac tgatggtagt cgccgacata acgtgtcagc tcttgatttt 764821 caacgtgata aatcaggttg atgacactat tcaagaacgg aatatcgtgg gaaatcagga 764881 tgaacgcgtt ctcgtattcc tgcaggtagc gtttcagcca ttcaatatgc tgttcatcaa 764941 gatagttggt cggctcatcg agaagcagaa tttccggctt ttcaaggaga agcttagcga 765001 gaaggacctt tgtgcgctgt ccgccgctca aatcggtgac atctcgctct aaaccgatat 765061 cgctcaaacc gagaccgcgg gcgatttctt ccaccttgga atcaatgaca taaaaatcat 765121 tgtttgtcag cgcgtcttga atgacgccga cttcttcaag cagcttctcg agctcgtcgg 765181 gatcagcctc gcccattttg ttgtaaatct cgttcatttc ctcttccatc gcaaataaat 765241 aatggaatgc gtctttcagg acgtcgcgaa tggattttcc tttttccagc acggtatgct 765301 gatcaaggta tccgacacgg acattttttg accattcgac ttttccctca tcaggttcaa 765361 gctttccggt aataatattc atgaaggttg attttccttc accgtttgcg ccgatcaagc 765421 cgacgtgctc gccttttaac aggcggaagg aaacgttatt aaaaatggcc cggtccccga 765481 aaccgtggct taaatccttt acagataaaa tactcatgtt tacacctcta tcgttatcaa 765541 acacgcacaa tcggcgtgta atattcaccc ttttgattat aaaggaggat tcggaatgtt 765601 gaaaggtata ggaaagaaaa agaaaaattg cgttccgggc gaggttttga gatactatgg 765661 aatagatttc aggaattgag gagaacaaaa tgacgcaaac ttggccattt ttacataatg 765721 cacaatcatt tatacaagag aattggaatg cttccggctt tcaaaagcca acccctgttc 765781 aggagcaggc agcccagctg atcatggacg gaaaggatgt cattgcagaa tcgccgacag 765841 gcacagggaa gacgctggcg tatgcgctgc cggtcttgga gcggatcaaa ccagagcaaa 765901 agcatccgca ggcggtgatt ttagcgcctt cccgtgagct ggtcatgcag atttttcagg 765961 tgattcagga ttggaaagcg ggctcagagc tgcgcgcggc ttccttaatc ggcggggcga 766021 atgtgaagaa acaggtcgaa aagctgaaga aacatccgca tatcatcgtc ggcacgccag 766081 gcagggtgtt tgaactgatt aaagcgaaga aactcaaaat gcatgaagtg aaaacgatcg 766141 tgcttgatga aacggatcag ctcgtcctgc cggagcatcg cgaaacgatg aagcaaatca 766201 ttaaaacaac attaagagac cgccagcttc tatgtttttc tgccacgctc aaaaaggaaa 766261 cagaggacgt gctccgcgaa ttggcgcaag agcctgaggt gttgaaggtg cagcgaagca 766321 aggcggaggc agggaaagtg aagcatcaat acctgatttg cgaccagcgc gacaaagtga 766381 agctgctgca aaagctgtca aggcttgaag gcatgcaggc actcgtattt gtgagagaca 766441 ttggcaacct gagtgtatat gcggaaaaac tggcatatca ccacgttgaa ctcggcgttt 766501 tgcacagtga agcgaaaaaa atggagcgag cgaaaatcat tgccacattc gaagacggag 766561 agtttcctct tttattggcg actgacattg ccgcacgcgg tttagatatt gaaaacctgc 766621 catacgtgat tcatgctgat attccagatg aagatggcta tgtccacaga tcaggacgaa 766681 caggccgggc cggaaaagaa ggcaacgtgc tgagccttgt gacaaaattg gaggaatcta 766741 agctgaaaaa aatggcgaag aagcttggtg ttgagctgag tgaagctgtg tatgcaggcg 766801 gaaaactgaa gacgaaataa aaagaagggc gaagagccct ttttttgttg taaaataata 766861 gaaaagattt tgcgcggagg tgggaaaatg gcttcaatag acaggtttca agtaatgcag 766921 gagccagagc tgaaaatcct tgaacactgg tttgagaatg aggataccag acggagaatg 766981 gatgggatgc tgctattaga tgagtggtat gcacgagtaa ataaagataa acacgatact 767041 gtcatcatgg cgtatgatgg acagctgccg gcagggatgg tcgttattga gttcggagag 767101 gagcggacat atattggatt gatcgtcaat cctttgtacc ggcttaaagg gtatggaaaa 767161 cagatactgc aaaagctgat gaccgaacct gattttacta gcgtgcgaga atgggtggca 767221 tgcattgaag aagacaatcg aatcagttta gcttgctttc aagcagcagg attcacttta 767281 gaagacacgg aacctgatga agatggtttt cttacgctga ttcttcgcaa ctgatctcat 767341 cgaaacacaa aaggagggca aaaagccctc ccgttttcat cttcattcag ctcggatcac 767401 tgaccttgat cagctgtttc cctttatttt ctcccttaaa taaaccgaga aacgcgtcag 767461 gaatgttttc gaagccttct gtgatggttt cctcgtaatg gagtttacca gccttcagcc 767521 attctgccag ctgttttgct ccctcagaaa aacgatcgga gtagtcgctt acgataaagc 767581 cttgcatcag cgacttcgtt ttaatgagtt ttgattggac acgagggccc atgtcatctg 767641 cttcgctttc tgcgttatag gaagaaatgg cgccgcacac cggaatgcgg gcaaattcat 767701 tgagcagatt catcaccgcg tctgaaatcg gtccgccgac attgtcaaaa tacacatcga 767761 caccgtcagg acaagcgttt tgaagcgctt tttggatatc atccgctgtt ttgtaattga 767821 tggcttcgtc aaactgaagc tcctgtttta aatagtcgat tttttcatca gagcccgcga 767881 tgccgacgac tcgcgcgcct ttgattttgg caatttgccc gactgttgaa ccgacggctc 767941 cggcagctcc tgagacaacc acggtttcgc cttccttcgg gcgtccgatg tccagcaatc 768001 cgaagtatgc tgttaagccg gtcattccca aaatgccgag ataggccgaa gcgggagcaa 768061 ggcttgtatc aatttttcgc aaggcagact cgctcacagc ggaaaattcc tgccagctga 768121 gatttccgat gacgatatcg ccttttttca gatgattccc gtctgacaca acttcagcga 768181 taacccctcc agaaagcgct ttatccaagg cgaacggctc aacatatgac ttcgtatcct 768241 gcatacggcc gcgcatataa gggtcaaccg atacataaag cgttttgaca agcacttccc 768301 cttgcttggg ttcaggaacc ggaatggttt caaagcgaaa gtcttcatga acaggaatac 768361 cttgtggacg tcttgctaat tgaatttgct gctgagatgc tgtcattttc atcctcctat 768421 cacttggttg acaccactgt aacatggaca ggagaggaaa tacaaaaggt aagctggcat 768481 acaaaaaagg ttatagatga gcttatgctt tctacaagct cttttgtttt aaaagttctc 768541 tttagtcatt tatcattatt agaaaacaga acagaaaaag agctcctgta cacctagcta 768601 agattggcta gtgtgtatgt cgattctttt tcatattctt gcaagcatct gcgaggggga 768661 gcttagtcgt tcacattttg ctttcgcatc aatctgcaat agcaaagtct atgcgatttt 768721 tttacatcag caaagatttg ttcaattttt tccttttatg ccgagttttt ctgaaacaga 768781 taattgatgg tactcaacca ttttcttttg gtcaataaag taatgtttac ttattaatta 768841 aacacgcgaa aaagcaaacg aaaacataat taaattttat atatttatta aaagcttata 768901 tgtttattta cctttttttt gaattgtaat tgagaaaatc catatattgc ggacactaat 768961 aaaagaatac ctgctgaaac ataaactaaa cgaactccaa ggaaatctga aatagcccct 769021 atagccagaa ttgaaaacat aaaaatgaac tgtactaaag aagaccttgc agacattata 769081 ttaattcgag tttgctcggt tgttatgttc tgaataagtg tttcttgtgt aagatctctt 769141 aatatataag ccggccccat aaagagaacc aaaattagag ctaagtatga attacttata 769201 aaaccatata ttaaagttaa acttccatat gagacagcgc caattaacat aaaattaatt 769261 aacttatttt gaaatctctc cgacagctta tatattataa atccccctat catcgaacct 769321 aaataatatg ctccattaat aaatccccac catgattctc ctttatgcaa gacttcgtta 769381 acgaaagcta aagagacaga tcctatccaa atcattcctg cccatgactc aattaaatcc 769441 ataataataa ttgttctaag tttcttttgg ctaaataaat accgccaacc acttactata 769501 ctcttattgg gagaattttt ttcacgtatg acagaattag cgtggccatg tggtagacaa 769561 aataaaagag aaagaagaga tgtaaacaac aaaaagatag taagtataat ggtatatccc 769621 tcacctaaaa atgcaattat gagaccacct aaagaccagc ctacaaattg aaaagtttgg 769681 tccactgtag ataataatcc atttgctttt actcttctat caggagagat tatttcccct 769741 ataattgcac tttttaaagg tgagaaccat ccattaaaaa aggaaataca gctaataata 769801 ataaagacta aaatgagagt ttgattagag taagttctta ataaagcata gaacaaacat 769861 attaataaca gcatttgtat caattgagaa ataattattg taagaggcag ttttaatcga 769921 attgttatta acggtaatat agcacttcca aaaatacgaa aaataatact tattaatgtc 769981 accatagagg cgatggttgt cgaattggtc attttaaaca aaaacgaaat cactaccata 770041 gtatatagag aaaaacctaa atttgtagtg gtctggctaa ataaaataga ataataacct 770101 ttactcatat gtatcctccc ttggaataat ttttctcggt aaagagctta aacatattta 770161 aacaccttaa aacaacaaaa gtaaagaaaa aatttccttg taaactattt acttttattc 770221 tatttattgt tattgtttat ttaagttctc tgactattct atcaatattc agggaaccac 770281 atatcttatt aaagggggga aaaccatgag aaaattaaga aaaaactgga gaaaatcgat 770341 tgttagcccg gttctttata ctaatgaaaa atggtaaaca cttagggaat agcatttaat 770401 gctattcctt atttcaacaa acaaatcggg aggttatcgt aatttgactc tattaatgca 770461 agatcataaa tcaatttaca ataaagatat agaaatatta attgaagttg aagaacttat 770521 tacttctgtt ccagaaaata aaaaaaatga ttttaagagt ttaatcgata atagaattat 770581 gactctacta aataaaattc aacaccctgt agcagcggaa aatgtgtttg ggatgtgtat 770641 tgcttatccg aatacttaca taaggtatag attaattgat ttcgttgaaa aatgggtacc 770701 ttatttctct gctgtagaaa ctataatcaa tctaacccag gatccggatg atttagtttc 770761 ttttaaagct atggatgtct gtgcaaatca taaaattgaa gaatctgtag catatttgtc 770821 ttcgattatt gatgatgtcc gggagagtat aagctaccct aaaaaacctg tgggattagg 770881 ggcccaaaaa gtattaagta cattattaga tatattcggt gttgaaaaac atgaagagct 770941 agtaatgcta aaaaattatt ttgatcaaaa tggtatactt cctaataact ttgactttga 771001 agaaaaaatt cctcaaagtc taatagagga attcgaaaaa acagaagaag atgggatgat 771061 tttaattccg ggtggctttt ttgaattcgg tttaaatgaa aatgaaattc ctgacaaaac 771121 atttaattgg aaagatgctg ttcctagaca aaaagtatgg ttacctccat tttttatcga 771181 taagtatcct gttacaaata aagattatga tatctttacc gagttcatag aggaaaatgg 771241 gcatatattc tgtcatccta atgaaccgca gaataaacaa catagaagaa atacatattg 771301 ggatgatagg tatttagata atcatcccgt tacaggtata gatttttatg atgcatttgc 771361 ttacgcaaga tataagggga aagaattgcc aaccgagttt caatgggaaa aagctgctcg 771421 aggcgaaaag ggtaatgtct ggccttgggg agataaattt gatcctgcaa aggttcaata 771481 tgctggaagt ctttataatg aacccattac ttctttaaag tcctggagag aaaatttatt 771541 aaaagctcat gctgataaag aattaaatca tttaacaagt gatatttttg aacaaaatgg 771601 tgaaagtccc tatggagtat gcggtatgat cggcggaaca tgggagtgga ctagaagtga 771661 gcttaaaaca aagagagctt tccaccctat ttttgagaat gtaccattta atagtgttaa 771721 ctcatttgcc gttcttaaag gaggatcatt cttctctcat ccaggcttaa tgttcccttc 771781 ttttagagca aaagatattc ctttctgtcg acacaatgaa atggggatta gatgcgtaaa 771841 gaatattcca gtatataaaa ttagagaatc aattaatggg ccaattacta ataaagcaat 771901 ttattaatca ttctaggtta gagacttgat aaaagtatac taacattgtg tagtaatgtt 771961 cagcttgtag aaaaaacaat gttttttcta caagatttta ttttaaatgc ttttcaaaat 772021 tatcagggat tgagaatcag aaaaagagcc attaagctcg atcttagcta ggtattacga 772081 tcttctgtat attattgtga gaaatataga agattcagtt agttagcatt tcgattttaa 772141 gctgagcctg caatagcaaa gcatctgttt tgattattct ttttctgata cataagctaa 772201 ttttgtcgct tttctttttt gtcttttcac gcatttcgag gatgacttac tataattctt 772261 tcagcttttc tatgtgttaa gattcgaata gatgaaataa ctttaacaag ttggtcaata 772321 agaacagatt taactttatg ttaaaagagt atctcgtata gaacataaga agaatgacga 772381 gttttttaag attatcatca attatgtgag aataaaatat tataagggaa aatgaaggct 772441 gtcacgtttc tcgacagccc tagggaattc ctctcctttt catttcgccc gtaatttcgg 772501 gcacagtccc gtcggcaggc acattggctt ctggtcgatc gggcttctca tgatgcagca 772561 ttccaagccg aagacttcac ggaaaaatgg ctgggtgaac acatcttccg gtgttccggc 772621 gttgtatatt tttccgtcca gcacactgat cagatagtca gcatattgag cggcttggtt 772681 taaatcatgg agcaccatga caacggtgcg gccatggtcg cggttcagct ttttcagcag 772741 ttcaagcact tcaatctgat gtgagatgtc taaatacgtg gtcggctcat caagcaaaag 772801 caaatcagtg ccttgcgcaa gtgccatgga aatccaggct ctttgtcttt ggccgcctga 772861 gagggcatca agtgtccgat ccttcagttc aatcatgccc gttgcttcca gcgcccactc 772921 taccatgtca tgatcctctt gggtatgctt ggataacagc tttttgtgag gatgtctgcc 772981 aaaatagcat aattcctcta ccgtcaatcc ttcaggagcc tgaggagatt gtggaagaat 773041 ggccagtttt tttgcgactt cttttgatgg ctggcggtgg atgtcttttc cttctagtag 773101 cactgtaccg ctttttgggg ccatcagcct ggcgagcgat ttgaggattg ttgatttacc 773161 gcagccatta gcgccgatga gcgcagtgat ttttccttct tctatcttta agtcgactcc 773221 gtcaataatc actgtactgt catatgaaag agtgagctgg tctgcagcca gttttcccat 773281 ggtatcctct ccctactgtt tcctcgcttc gaatttcaat aaatataaga aataaggcgc 773341 gccgatcacg gctgtcagta ttccggcagg tatttcaacc ggaggcatga tgccgcgccc 773401 taacgtatct gcaattaata atataatagc accaatcaat gccgatgcag gcagtaaata 773461 tttagctttt tctccggtaa gccgtctggc gatatgcgga gcaagcaagc cgataaaacc 773521 gattgagccg acgacggcta cacagcttcc cgccagcgcc accgcggtga aaatcaggat 773581 gaatctcagc cggtttgcgt tttctccgag accctgtgca agctcatccc cgagtgacat 773641 aagatccagc ttcggtatga gtatgcagac gatcggaaaa agaatcaaaa gccatggcgc 773701 aagcagcttg acttcttccc agtttcttcc ccagaggctt cctgtcagcc aaatgagtgc 773761 agcattcacg tcgcctggaa acttgaccat catatattgc attccggcgt ggcagaccgc 773821 gcctaaagca atgcctgata aagccagtga agagggctga atgctctttt ttcgggctat 773881 cattaataat agtacagcaa taatggcggc tccggcaaat gcggagaacg gaagcacgta 773941 taccggcgac tcaggaaaga tgagaatcac agccatcgcc gcaagtccgg agccttttga 774001 aatgccgaca acgtccgggg aagcgagcgg atttcggatc acaccctgta aaatcgctcc 774061 ggcagcggca agtccagcac ctgccaaaat cgctaatata atgcggggaa ggcgatattg 774121 ctggatgata aattcaaagg aatgatccag tcccagcaga ttcgtcacta ccgcatcagg 774181 tgaaatgtat aatgcaccga ttccaatgct gatgacggac agaacgatta aaatcacggc 774241 caatatgagt atcgccagta aggggcgttt ttgttttctg gttgttttct tcatttcagg 774301 tttcgccctt tccttgccaa atataagaaa aacggcgttc cgataatcgc ggtgacaatg 774361 ccgaccggtg attcataagg aaatgcaatc catctggcca gaacatctgc gtacaccagc 774421 aaaatggcac cgaacagtgc cgaaaacgga agcacgtatt gataatgttc tccgatcagc 774481 ttgcggacaa tatgcgggac gagcagcccg acaaagccaa tcggcccggc gacggctacg 774541 gaagcgccgg aaagaattaa aataatcaaa ctgatcagaa tcctgatgcc gttcatattt 774601 tgtccaagcc cttttgctgt ttcgtctccg agaccgagaa cagaaacaga accggaaaat 774661 acgagggcaa gcccgatgcc aatgacagaa aaaggagcga tggttatgac gtcctgccag 774721 ttgctgccgt cgattgcgcc tgtcatccag tacagaacat cctcacctga ctcatttaaa 774781 ataatgatgg cctgtgtcat agaggagagg aacaagtgca cggccattcc tgacagcgcc 774841 agcttgacag gcgtcattcc gccggatgag gcaatcatat acacaatcgc gccgcctgct 774901 gccgcacccg caaaagcgaa tataacagat gaatagggcg atgccggcag aatgacgaga 774961 gaagcaacaa caaaaagcga tgcacccgca ttcacaccga aaatttgggg tgaagccaga 775021 ggatttctgg tcatagcctg catcagcgcc cctgctacag ctaggctggc gccgacaaaa 775081 acgccgatta atgtgcgggg aaggcgaaga gtagagatga tgagctgttc ctttgaaccg 775141 tcccatacaa aaagatattt caatgaatct atgatgctga tgtctgaggc tcctactgaa 775201 agattcagcc caagcccaaa tataaaaata atcagtgcaa tgataaacat catcagtctt 775261 gatgatgagc gccgtttggc tgaatgatac aacagtctca cttccttact gcgtctggtt 775321 gcaaaaacga agaagcaagg attcccctcg cttctcattt gtcctattta ttatacactt 775381 ttttaagcac atctttggcg cttgtttcac tagacttgat gcctctgaat cttgtccaag 775441 tgtcacggtc cgcatcatag acttgtccat ttttcaccgc tttgagattt ttccagagcg 775501 ggttcgtttt ccactcatct acaatggttt tgccttcgtt ggctgagatg aacaaaatat 775561 caggatcgat tttgctcaat tgctcaaggc tgacctcttg ataggcgtta tctgacttca 775621 cagcgtgtgt aaagcctagc attttaaaga tttctccgtc ataggatgat gatgtatgaa 775681 gctggaagga atccgctctt gcaacgccga gaacgatgtt gcggttttca tctttcggaa 775741 gttcggcttt tagatcgttg atgacttttt tgtgctcggc aagcttttct tttccttcat 775801 cttctttatt taatgcttta gcaatggtcg taaagctgtc gatcgtttcg tcatatgtcg 775861 cttcacggct ttttaattca atcgtcgggg cgattttttt cagctgttta taaatgtttt 775921 tatggcgctc agcgtcagcg atgattaaat caggcttcaa ggaactgatg acctcaagat 775981 tgggttcgct gcgtgtgcct acagatgtgt aatcaatgga gctgccgaca agctttttaa 776041 tcatatcttt tttgttgtca tctgcgatgc ccaccggcgt aatgccgaga ttgtgaacgg 776101 catccaagaa tgaaagctca agcacaacca cccgcttagg tgtgccgctt actgtcgttt 776161 ttccttcttc gtcatggatc actctggaat ccttagactc gcttttgccg cttccgttgt 776221 tattctggct tgatgaacag ccggatacaa tgaggcaggc gagcaataaa acactcatga 776281 tggcaatcaa cttgttagaa taggtgcgca tgtcattctt ccttttttca gatttagtaa 776341 tgagaatcat tatcacatgt aacactataa tagcatggct tatcatgtca atattttttt 776401 agtaaagaaa gctgcgtttt tactgctttc tcatgaaagc atcatcagac acaaataagt 776461 ggtatgcagc gttaccgtgt cttcgagaca aaaacgcatg ggcgttggct ttagaggttt 776521 cgaacatatc agcagtgaca taaggaagga gagtgctgag ataaccggac aatttctttt 776581 ctatttcatc tgttagtgca aattcaatgt cgccgatatt catgataatc gagaaaacaa 776641 agtcgatatc gatatgaaaa tgttcctcgg caaaaaccgc aagctcgtga attcctggtg 776701 aacatccggc acgcttatgg aaaatctgtt tgactaaatc actcacaatc caagcattgt 776761 attgctgttc tggtgaaaag tattgcatta gacatacctc ctgctcgtac ggataaaggc 776821 agcgtttcat ggtcgtgtgc tccgtgcagc ggcttctcct taattttgat ttttctgaaa 776881 ataggtcccg ttcctatcac tttaccatgg acggaaaaca aatagctact accattcctc 776941 ctgtttttct cttcaatgtt ctggaatctg tttcaggtac agacgatcgg gtatgaaaga 777001 aatatagaaa acatgaagga ggaatatcga catgaaacca gttgtaaaag agtatacaaa 777061 tgacgaacag ctcatgaaag atgtagagga attgcagaaa atgggtgttg cgaaagagga 777121 tgtatacgtc ttagctcacg acgatgacag aacggaacgc ctggctgaca acacgaacgc 777181 caacacgatc ggagccaaag aaacaggttt caagcacgcg gtgggaaata tcttcaataa 777241 aaaaggagac gagctccgca ataaaattca cgaaatcggt ttttctgaag atgaagccgc 777301 tcaatttgaa aaacgcttag atgaaggaaa agtgcttctc tttgtgacag ataacgaaaa 777361 agtgaaagct tgggcataaa gcaaggaaaa aaccaaaagg ccaatgtcgg ccttttggtt 777421 tttttgcggt ctttgcggtg ggattttgca gaatgccgca ataggatagc ggaacatttt 777481 cggttctgaa tgtccctcaa tttgctatta tatttttgtg ataaattgga ataaaatctc 777541 acaaaataga aaatgggggt acatagtgga tgaaaaaagt gatgttagct acggctttgt 777601 ttttaggatt gactccagct ggcgcgaacg cagctgattt aggccaccag acgttgggat 777661 ccaatgatgg ctggggcgcg tactcgaccg gcacgacagg cggatcaaaa gcatcctcct 777721 caaatgtgta taccgtcagc aacagaaacc agcttgtctc ggcattaggg aaggaaacga 777781 acacaacgcc aaaaatcatt tatatcaagg gaacgattga catgaacgtg gatgacaatc 777841 tgaagccgct tggcctaaat gactataaag atccggagta tgatttggac aaatatttga 777901 aagcctatga tcctagcaca tggggcaaaa aagagccgtc gggaacacaa gaagaagcga 777961 gagcacgctc tcagaaaaac caaaaagcac gggtcatggt ggatatccct gcaaacacga 778021 cgatcgtcgg ttcagggact aacgctaaag tcgtgggagg aaacttccaa atcaagagtg 778081 ataacgtcat tattcgcaac attgaattcc aggatgccta tgactatttt ccgcaatggg 778141 atccgactga cggaagctca gggaactgga actcacaata cgacaacatc acgataaacg 778201 gcggcacaca catctggatt gatcactgta catttaatga cggttcgcgt ccggacagca 778261 catcaccgaa atattatgga agaaaatatc agcaccatga cggccaaacg gatgcttcca 778321 acggtgctaa ctatatcacg atgtcctaca actattatca cgatcatgat aaaagctcca 778381 ttttcggatc aagtgacagc aaaacctccg atgacggcaa attaaaaatt acgctgcatc 778441 ataaccgcta taaaaatatt gtccagcgcg cgccgagagt ccgcttcggg caagtgcacg 778501 tatacaacaa ctattatgaa ggaagcacaa gctcttcaag ttatcctttt agctatgcat 778561 ggggaatcgg aaagtcatct aaaatctatg cccaaaacaa tgtcattgac gtaccgggac 778621 tgtcagctgc taaaacgatc agcgtattca gcgggggaac ggctttatat gactccggca 778681 cgttgctgaa cggcacacag atcaacgcat cggctgcaaa cgggctgagc tcttctgtcg 778741 gctggacgcc gtctctgcat ggatcgattg atgcttctgc taatgtgaaa tcaaatgtta 778801 taaatcaagc gggtgcgggt aaattaaatt aagaaagtga aaaacacaaa gggtgctaac 778861 ctttgtgttt tttaattaat taaaatgttt attaacttag ttaaggagta gaatggaaaa 778921 ggggatcgga aaacaagtat ataggaggag acctatttat ggcttcagaa aaagacgcag 778981 gaaaacagtc agcagtaaag cttgttccat tgcttattac tgtcgctgtg ggactaatca 779041 tctggtttat tcccgctccg tccggacttg aacctaaagc ttggcatttg tttgcgattt 779101 ttgtcgcaac aattatcggc tttatctcca agcccttgcc aatgggtgca attgcaattt 779161 ttgcattggc ggttactgca ctaactggaa cactatcaat tgaggataca ttaagcggat 779221 tcgggaataa gaccatttgg cttatcgtta tcgcattctt tatttcccgg ggatttatca 779281 aaaccggtct cggtgcgaga atttcgtatg tattcgttca gaaattcgga aaaaaaaccc 779341 ttggactttc ttattcactg ctattcagtg atttaatact ttcacctgct attccaagta 779401 atacggcgcg tgcaggaggc attatatttc ctattatcag atcattatcc gaaacattcg 779461 gatcaagccc ggcaaatgga acagagagaa aaatcggtgc attcttatta aaaaccggtt 779521 ttcaggggaa tctgatcaca tctgctatgt tcctgacagc gatggcggcg aacccgctga 779581 ttgccaagct ggcccatgat gtcgcagggg tggacttaac atggacaagc tgggcaattg 779641 ccgcgattgt accgggactt gtaagcttaa tcatcacgcc gcttgtgatt tacaaactgt 779701 atccgccgga aatcaaagaa acaccggatg cggcgaaaat cgcaacagaa aaactgaaag 779761 aaatgggacc gttcaaaaaa tcggagcttt ccatggttat cgtgtttctt ttggtgcttg 779821 tgctgtggat ttttggcggc agcttcaaca tcgacgctac cacaaccgca ttgatcggtt 779881 tggccgttct cttattatca caagttctga cttgggatga tatcaagaaa gaacagggcg 779941 cttgggatac gctcacttgg tttgcggcgc ttgtcatgct cgccaacttc ttgaatgaat 780001 taggcatggt gtcttggttc agtaatgcca tgaaatcatc cgtatcaggg ttctcttgga 780061 ttgtggcatt catcatttta attgttgtgt attattactc tcactatttc tttgcaagtg 780121 cgacagccca catcagtgcg atgtattcag catttttggc tgtcgtcgtg gcagcgggcg 780181 caccgccgct tttagcagcg ctgagcctcg cgttcatcag caacctgttc gggtcaacga 780241 ctcactacgg ttctggagcg gctccggtct tcttcggagc aggctacatc ccgcaaggca 780301 aatggtggtc catcggattt atcctgtcga ttgttcatat catcgtatgg cttgtgatcg 780361 gcggattatg gtggaaagta ctaggaatat ggtagaaaga aaaaggcaga cgcggtctgc 780421 ctttttttat tttcactcct tcgtaagaaa atggattttg aaaaatgaga aaattccctg 780481 tgaaaaatgg tatgatctag gtagaaagga cggctggtgc tgtggtgaaa aagcggttcc 780541 atttttccct gcaaacaaaa ataatggggc tgattgcggc tctgctggtc tttgtcattg 780601 gtgtgctgac cattacgtta gccgttcagc atacacaggg agaacggaga caggcagagc 780661 agctggcggt tcaaacggcg agaaccattt cctatatgcc gccggttaaa gagctcattg 780721 agagaaaaga cggacatgcg gctcagacgc aagaggtcat tgaacaaatg aaagaacaga 780781 ctggtgcgtt tgccatttat gttttgaacg aaaaaggaga cattcgcagc gcctctggaa 780841 aaagcggatt aaagaaactg gagcgcagca gagaaatttt gtttggcggt tcgcatgttt 780901 ctgaaacaaa agcggatgga cgaagagtga tcagagggag cgcgccgatt ataaaagaac 780961 agaagggata cagccaagtg atcggcagcg tgtctgttga ttttctgcaa acggagacag 781021 agcaaagcat caaaaagcat ttgagaaatt tgagtgtgat tgctgtgctt gtactgctgc 781081 tcggatttat tggcgccgcc gtgctggcga aaagcatcag aaaggatacg ctcgggcttg 781141 aaccgcatga gatcgcggct ctatatcgtg agaggaacgc aatgcttttc gcgattcgag 781201 aagggattat tgccaccaat cgtgaaggcg tcgtcaccat gatgaacgta tcggcggccg 781261 agatgctgaa gctgcccgag cctgtgatcc atcttcctat agatgacgtc atgccgggag 781321 cagggctgat gtctgtgctt gaaaaaggag aaatgctgcc gaaccaggaa gtaagcgtca 781381 acgatcaagt gtttattatc aatacgaaag tgatgaatca aggcgggcag gcgtatggga 781441 ttgtcgtcag cttcagggag aaaacagagc tgaagaagct gatcgacaca ttgacagagg 781501 ttcgcaaata ttcagaggat ctcagggcgc agactcatga attttcaaat aagctttatg 781561 cgattttagg gctgcttgag cttggggagt atgatgaagc cattgatctg attaaagagg 781621 aatatgcgat acaaaatgaa cagcatgatc ttttattcca taacatccat tcgcagcagg 781681 tgcaggccat tttgttaggg aaaataagca aggcatcgga aaagaaggtc aagctggtga 781741 ttgatgagaa cagctcactc gcgcctcttc ctgcgcatat cggcttgtcc catcttatta 781801 cgattattgg caatttaatt gataacgctt tcgaagctgt agcggagcaa agcgtgaagg 781861 aagttttgtt ttttatcacg gatatgggcc atgacattgt cattgaagta tcagacacag 781921 ggcccggtgt gccgccagag aaaatagaag ctgtgtttga gagaggctat tcttcaaagg 781981 ggatgaggag aggctacggt ctggccaatg tgaaagactc agtgcgtgaa ctgggcggct 782041 ggatcgaact ggcgaatcaa aaaactggcg gggcggtatt cactgtattt ataccgaagg 782101 agaaacaaag ggggaatcca tttgattcac atcgcgattg cggaggatga ttttcgagtt 782161 gcgcaaatcc atgagagatt gattaaacag cttgatggat tcaagattat cggcaaggcg 782221 gctaacgcaa aagagacatt ggcgcttttg aaggaacaca aggctgattt gcttctgctg 782281 gatatttata tgccggacga gcttgggacc gcgttgattc ctgatatacg aagccgattt 782341 cctgaagtgg acattatgat tatcacagcg gcaacagaaa cccgtcattt gcaggaagcg 782401 ctaagggcgg gaattgccca ctatttgatc aaacccgtaa cagctgacaa gttcaggcag 782461 gtgctgcttc agtataaaga aaaaaggaag ctgctcatgt ctcagccgga ggtcagccaa 782521 tccatgatcg accatatttt tgggaacggt gtgaagacag ctttgccggc agaggatttg 782581 ccgactggca ttaattcgat tacactgcga aaaattaagg aagcgcttca gactgcgtca 782641 gaaggattga cagcggagga acttggggaa aaaatggggg cgtcacgaac aactgcccgc 782701 cgttatgccg agtaccttgt gtcaaaggaa gaagcaagag ccgagcttga atacgggatt 782761 atcggcaggc cggagagaaa atattatttg gcggcggatt agatatgaaa aaatctataa 782821 tcctattgaa tattctattg atctttatgc agggtgatat caggcaggcg gctgcgccgc 782881 gcctgccgga cgggccgata gaaattgtcg tccctgccga accttctggc ggctgggatg 782941 tcacagcgca ggcgatccaa tcagttttga ggcagaagca gatcgtgaag gatgatgttc 783001 atatcgtcta taaatccggc ggcgggggag agaaaggctg gaaatatgtc aacaaaagca 783061 gcaaacaaac catcagcatg acgtccagcc taatattgag caatgatctt ctcgggcaaa 783121 gcaaattaaa aatgtccgat tttacgccgc tcgccattct ctccaaggaa tggcagacgg 783181 ttgcattgcc aaaaggatca gcgttaacaa atggcaagga tgtgctgaat gagatcaaca 783241 tgcatcccgg caaggtgaga atcggctttg ccccggggtt tggcaatgat gatcagctct 783301 cgttcgtcag agcggcagat atgtacggca ttgacccgtt tgacattcaa ttctcacagt 783361 atgacagcag cgaacagctc attcaggcgc tgatcagaca tgagatagaa gcggcttcca 783421 tgacactttc tgaagcgaaa ccatatgaac gaaacggcga tatcacgtta gccgctgtaa 783481 cgtctgataa aagacttccc ggttttccaa atgtaccgac gtggaaggag cagggaatcc 783541 cgtttgtttt ttctcattgg agagggattt tgggcccgaa aaatatgtct gaggaagaga 783601 tttcttactg ggatcaagcg ctaaagaagg tcacctcctc acctgaatgg aagcggaaaa 783661 taaacgaaca ggactgggaa agcttttatt taaacagcag ggaaacgaaa cggtttttag 783721 aagagcaatc tgctttttat caaagcatca tgacaggaaa ttaaaatccc gacatcccgg 783781 gatttttttc atgccgaaaa ttgatcaaaa agaacaaaac ggttttaaaa aattaaaaat 783841 acaaaaaaac caaattattt acttgcggtt ggttttccca tacgatggca aaaaggcaag 783901 acaaaaaggg gagtaaggga gaaaaaaatg taagcggatt catttaaggg ggaatggatg 783961 tgttagcaat cttaggcttt ctcatgatgc ttgtgtttat ggcattgatc atgacaaaac 784021 ggctttctgt tttaacagca ttagttttga cgccgattgt gtttgcgctt atcgccggat 784081 ttggatttac tgaagttggg gacatgatga tttcggggat tcagcaagtc gcgccgactg 784141 cggtcatgat tatgtttgcg atcttatatt ttggaattat gattgataca ggcctgtttg 784201 atccaatggt tggcaaaatt ttaagcatgg tcaaaggaga ccctttaaaa attgttgtcg 784261 ggacagcggt tcttacaatg ctcgtcgcct tggacggaga tggctcgaca acgtacatga 784321 ttacgacaag cgccatgctt ccgctctatt tgctgctagg catccggcca attatcttgg 784381 caggaatcgc gggagtcggc atgggaatca tgaacacgat tccatgggga ggtgcgacgc 784441 cgagggcggc gagtgcgctg ggggttgatc cagctgagct tacagggccg atgattcctg 784501 tcattgcaag cgggatgctt tgtatggtgg cagttgcgta tgtgcttgga aaagcggaac 784561 gaaagcgcct tggtgtgatt gaactgaaac agccagccaa tgccaatgaa ccggctgctg 784621 cggttgaaga tgagtggaag cggccgaagc tttggtggtt caatttattg ttaacgcttt 784681 ctttaatagg atgtttagta tcgggtaaag tcagtttaac cgtactgttt gtcattgcgt 784741 tttgtattgc gctgattgtg aattatccca atctcgagca tcagagacag cgcatcgcgg 784801 cgcattccag caacgtgctg gctatcggtt caatgatttt tgctgcgggg gtgttcacgg 784861 ggattttgac aggcacgaaa atggttgatg aaatggcgat ctcgctcgtg tccatgatac 784921 cggaacaaat gggcggattg atcccggcga ttgttgcctt aacaagcggc attttcacat 784981 ttttgatgcc gaatgacgcg tatttctacg gggtgctgcc gattttatca gaaacagctg 785041 tcgcatacgg tgtggataaa gtggaaattg ccagagcctc tattatcggc cagccgattc 785101 atatgctgag tccgcttgtg ccatccactc atttgcttgt cggactcgtc ggagtttcta 785161 ttgatgacca tcaaaaattc gcattgaaat gggcggttct cgcagtgatc gtcatgacgg 785221 ctatcgctct attgatcggt gcgatctcta tttccgtatg ataattcagg cgtaatgaca 785281 cacactaacg gcatacaaca ttccggaggt gtcattatga gtgatcctta tatgccgctg 785341 acttcagtca gaagcggagc ggggttcgaa gcggcaaaag gggtgcacgg cctgactgtg 785401 caaattgcga atgtctattt tattcagctg ccttctgaac ctcactcatt tgttttaatt 785461 gatgccggca tgccccaatc agccggcgtg attgtcaatg aagccaaaca aagattcggt 785521 gaagggtttc agctgaaggc gattatcctc acacacgggc actttgacca tattggggca 785581 atcgaagaga tccttgagca ttgggatgtg cctgtttata tccattctcg ggaaatgcct 785641 tatgtaacag gtaaagagga ttatcctccg gctcgtcctg acagcaagag cgggctggtc 785701 gctaagctgt cgccgctgtt tccgcggcac tctatcgata tttcctcaca tgtccaggca 785761 ctgccggaag acggttcagt tccttttctt gacgagtgga tgtggatcgc gacaccagga 785821 cacacgccgg gccatatttc gttattccgc gatgacggcc gcgtgcttgt ggcaggtgat 785881 gctgttatta cagtggaaca ggagaaaatg gctgacgtct tgatacaaaa acaggagctt 785941 cacgggccgc cggcttattt cacgcctgac acagagacgg ccgctgagtc cattctaaag 786001 ctggccggtc ttgaaccgga agcgttattg accgggcacg gcataccgat gaccggcaaa 786061 aactttcgaa gtgacttaac tgaattggca aatcggttat cgtctatttg acacccgcac 786121 cacgcgggtg ttttttattg ttttccagga agttgcagaa aaatcatttg tcttgccgct 786181 taaaaacgat acaatgaaaa gcatgaagtg atgtgaaggg gagagtttgt tggaagaaaa 786241 agaaatactc tggaacgaag cgaaagcgtt tattgccgca tgctatcagg aattgggaaa 786301 ggaggaggaa gtgaaagacc gtctcgcgga cattaaaagt gaaattgacc tgaccggaag 786361 ctatgtacat acgaaggaag agctggagca cggagcgaaa atggcttgga gaaacagcaa 786421 ccgctgcatc ggcagattgt tctggaattc gctgaatgtt atcgacagac gagacgtccg 786481 gacgaaggag gaagtgcgtg atgccctctt tcaccatatt gaaaccgcca ccaataacgg 786541 gaaaatcaga ccgaccatta cgattttccc tccggaagag aagggtgaaa agcaagtcga 786601 gatctggaat catcagctga tccggtacgc tggatatgag tcagacggag aaagaatcgg 786661 cgacccggct tcctgttccc tgacagcagc ctgcgaagag ctcggctggc gcggagagcg 786721 aacggatttt gacctgctgc cgctcatttt tcgcatgaaa ggggacgagc agcctgtctg 786781 gtatgagctg ccgcgttcac ttgtgattga ggttccaatc acacatccgg acatcgaggc 786841 gttttctgat ttggagctga agtggtacgg cgtgcctatt atttctgata tgaagcttga 786901 ggtcgggggc attcattata atgccgcgcc atttaacggc tggtatatgg gcacggagat 786961 cggagcgaga aacctcgcag atgaaaagcg gtacgacaag ctcaaaaaag tagcgtccgt 787021 gatcggcatc gccgctgatt acaatacgga tttatggaag gatcaagcgc tagttgaatt 787081 gaataaagct gtgctgcact cgtataaaaa gcagggtgtc agcatcgttg accatcatac 787141 agcggcaagc cagtttaaac ggtttgaaga acaggaggaa gaagcgggca gaaagctgac 787201 gggggactgg acgtggctga ttccgccaat ttcacccgct gccactcata tcttccaccg 787261 ctcctatgat aactcaatcg ttaagccgaa ctatttttat caagataagc cttatgagta 787321 aacaatagaa aatcgatgat ggccttcaag gctgcgggat tcagtcacag agatgtcggt 787381 aacctttgag aaagggcttc cgttctttac agcctcaaca aacgattgca gggcgttttc 787441 cggaccctct gccaaaatct cgacacgccc gtcatcacgg tttttgaccc agccggccag 787501 ttttcgctta tcagcttcca tttgaacaaa atagcgaaag cccacacctt gaacccggcc 787561 gtctacaatg attcggtatt gaagcatgta aaaaccacct tttcttttta tgataatcaa 787621 tcattttaca acctgtaaag gggatgtgtt tgtatgaaac aagagcgcta ttcagttctt 787681 tctcttaatc tgggaaaacc gcagacgctt gaatatgacg gaaagaaaat cgaaaccggc 787741 atcatgaagc ggccggctaa atcagccgtc atgctgtatc gggagaattt tgaaggagac 787801 ggacaggcgg acctcgtcaa ccacggcgga cctgataagg ctgtctgtgt ctacccggcg 787861 gagcattatc cgttttggga agagttcctc tcaagaccgc tgtcaaatgc cgcatttgga 787921 gaaaatctga cggtcgcggg cctgactgag gagaatgttt gcatcgggga tgtgttcaga 787981 cttgatgaag ctgttgttca ggtcagccag ccgcgccagc cgtgtgtaaa gctggcgaaa 788041 aagtttggtg taaaagaaat ggtgctgaag gtccagcaaa ccggctatac agggttttat 788101 tttcgcgtgc tggaggaggg cagggtgtct cccggcgcga accttgaatt gctgtccaga 788161 ggagagaaag gcatatccgt ccagttcgcg aaccgcatca actaccatga tgcaaaaaat 788221 ctcaccgcca ttgaacggat tttaagtgag gctgcactat cggaaagctg gagagcgtcc 788281 tttatgaaaa aaaaggacag gctgctgccg gttgaataga aaaaagccgc gcatatcaac 788341 gtgcgcggct ttgccatatt taagattgtt ttttctttga ttcaagcagg ttggcaagaa 788401 aataggtttt atagctttga agctttcttc cttcatggtg cgtgatcccc tgctttttta 788461 gttctgccac ataccagcct ttactgccgt aatgcatgtc agaaaactcc tttccctatc 788521 tgatttcgaa acgattggca ttgtaacatc tataaaaaga tgctgaaaag agatgcgggg 788581 aaaactgagc ctttcgcact agatgtacga atgttcttct gaatgtatat gcggagcaaa 788641 agccgaatat gatttaatgg ccggttagtt tgatcatgac aacgccaaat gtcataatgg 788701 cgaaaacaat gccgatatat gtgagcatcc cgtttttttt cttaacgccg taaacggtca 788761 taatgatgcc ttcaatgaaa aaaatgatgc cgaaaataat aaaccacatg cagataaagg 788821 ctcctttcac agacataata gtagtgtagc atatctgaaa gagccgggct gtgacaatat 788881 caagaaagcc gggcgcatat cgcccggctc atgttttatt gtttatcaac caatttgacc 788941 agaagctgtg ccaaatgttc tttctcatct tcgtctgcaa cgctccaaag ctcttgcagc 789001 agcatttctt caccgttttg cggctcttca tgctttgcga ggtagtctcc caggatcgca 789061 gcgcttttta caagcttgcc gtcatccaat cccagctttt tgcctcggtt gacttgtttt 789121 ttcaggtagc ctttaaattc ctcaaagtct tttaaaatgt cttcttttat tgtgccatgc 789181 atcgcgttca tttcgttttc aatttggatt ttttcttgat ctctgttcat tgcaagacct 789241 cctcgtacag aataatgatg ctttacctgc aattggagga ggttaaacct gccggaagcc 789301 cggaatgtgt tttacagttt cgtcaggata atcggttcat cttttgtgat gacgatcgtg 789361 tgttcaactt gggcaaccat gcttttatcc ggcgtcttga acgtccagcc gtctccagct 789421 tcaacaatcg tttctgcttt cgttgaaata aacggttcaa gcgcgatgac tgtgccattt 789481 ttgaacagcg cattatcaaa cggatcataa tagttcatga tgtggttcgg cgcttcatgc 789541 aggcttcggc cgattccgtg gccggtcagg gttttgatga cggtaaagcc ttgagagcgt 789601 gcttcatgat aaacggctct tccgatctgg ttttggcgct tgcccgcttt tgcctgctga 789661 agcccctttt gaaaagcgtt ttccgcgcat tggcaaagct tatgaaggcg ttcttctcct 789721 tcaccgagca caaatgagat gcctgtgtcg gaatagaagc cgccaaattc agcggagatg 789781 tcgatgttga caaggtcccc tgcttttaaa attttggatg tgcttggtat gccgtgagcc 789841 acttcatcat ttacgctgat acatgtcaca cctggaaaat cgtattcctt ctcaggagct 789901 gaaacggcgc cgtgctcatc aagcacagct tttccgataa ggtcaaggtc ttttgtgctc 789961 atgccgggct ctgccttccg cttcatttct tcacgcgcaa gcgcgacgat tcttccgatt 790021 tttttcaggc cttctaattc ttgatcgttt gttacaatca tctgtcattc ccgctttctt 790081 tttaaataat ctagattaag cttaccacaa ctgtcttaaa aataggaaac acacggacct 790141 gggaaaaaag aaataccccc gggaaaattg gtatagatca ctagatatct tatatggtat 790201 atttgaaaaa aaagggtatg agggggatgg gtatgctttc atttttacaa aaactcggga 790261 agtcatttat gctcccgatt gcggttctgc ctgcggttgg aattatcctt gcgcttggca 790321 gagaggatgt atttaatatc ccgtttgtct atcaggcggg gacggcggtt tttgatcatc 790381 tgccgcttat ttttgcgatc ggtattgcca tcggcatttc aaaagacagc aatggggcag 790441 cgggtttatc aggggcgata tcgtatctga tgcttgacgc ggcaacaaag acaattgata 790501 aaacaaataa catggcggtg tttgggggaa ttattgccgg tttaattgcc ggttacacct 790561 ataaccgctt caaggatacc aagctgcctg aatatctcgg gttcttcagt ggcagacggc 790621 ttgtgccgat tttaacagcc attattacga tcattttagc gggcatattc ggagtggtct 790681 ggccgccgat tcaatcgtgt atcaactcgt ttggagagtg gatgctcggg ctcggcggca 790741 tcggggcagg catattcggc ctattcaaca ggctgttaat tccgcttggc cttcaccatg 790801 tgctgaacaa tattttctgg ttccaattcg gagaatataa cggagtgaca ggggatttgg 790861 cgcgcttttt cgcgaaagat ccgactgcgg gcacatatat gaccggattt ttcccaatca 790921 tgatgttcgg tcttccggcg gcgtgtctgg ctatggttgt gactgcgaag ccgtctaaac 790981 ggaaagcgac ggctggaatg atgattggat ttgctttaac ggcgtttatc acagggatta 791041 cggagccgat tgagtttgca tttatgtttt tatctccgct tttatacgct gttcacgcgg 791101 tcttaaccgg gttatcttta tttatcgtca actggctcgg catccgctca ggcttctctt 791161 tttcagccgg agctatcgat tatgtgctca gctatggaat cgcggaaaaa ccgctgcttc 791221 tgcttttggt aggtatatgc tatgcggcag tatactttat cgtgttttat gtactgatta 791281 aggctttgaa tttaaaaacg cctggacggg aagacgatga tgtggatgaa gtgctggatg 791341 aaaatactgt tcaggatgta aatgaaaaca tcatgctgaa agggctcggc ggaaaagaaa 791401 accttcaaac cattgatcat tgcgccacaa ggctgcgact gactgtgaag gataccgctt 791461 tggtggatga agcactgcta aagaaagcag gcgcaaaagg ggttgtcaaa tcgggcgggc 791521 aatcggttca agtcattatt ggcccgaatg tggaatttgc agctgaggaa ttgagggctg 791581 ctgtcaaata aaaaagcgga gagggcaacc tctccgcttt ttcttattta tcttcgttat 791641 cctttgacgt ttcggaagaa tcttcgtcat gttttgtgta atcataatca gaaggattca 791701 ccttcttaaa acctttcggc tcgtagaacc gcagcaggtc tccgtttatg attttatcgg 791761 acatttcaag ttccttcttg acgagtgagt cttctgactt gtcgacttcg gattcatcga 791821 gttcttttcc ggttttcgtg tcgtaatact taccggatat tttcgtgtac ttcggtgaaa 791881 taaagtctcc gtttcggaac ggaatcactt cacggtgttc tttcgataaa atatcagaac 791941 cggacatcag atagtccttc gtatccactc cgagcagatg cagaatggta ggagccacat 792001 caacgtctcc ggcatattta tgaactttct cgcccttcac gccggcagcg tggataaaga 792061 gcggcacccg ttgaagctgg gcgttgtcgt aatcagtgat ttcatccttg ccaagcactt 792121 tcgccatcgc tttattgtgg ttttcagaga tgccgtagtg gtctccgtac atcacaataa 792181 tcgatttatc atataacccg tcttttttca gatcattgaa gaattgttca atggactgat 792241 caaggtaatg ggctgactgg aaatagttat cgacgacaga gtcaccaaag tctccagccg 792301 ggaagtctgt atccccctca tccattccga atgggaagtg gttggaaagg gtaatgaact 792361 tcgtatagaa cggctgcggc aggctttcca gcagcggcat tgattctttg aagaacggtt 792421 tgtctttcat gccgtagttt ttcgtgtttt cttcgttcat gtcatagtaa gcagaatcaa 792481 agaatttatc aatgccttcc gccttgtaca tttcgttacg gttccagaac gtctgcgtgt 792541 tcccgtggaa agtagcagat gtgtaattct tagacttcag aatcgccgga acggattgca 792601 gcgtgttttg cgctttgttt acgaaaactg aaccttgagc cagcgggtac agagagtttt 792661 ccatcataaa ttcagcatca gatgttttac cttgtcccgt ttggtggaaa aagttatcaa 792721 agtagaacgt ttcgttatca tgtgccagtt tatttaagaa tggtgtcact tctttgccgt 792781 caattttata gtcgatgata aatgactgca aagattcaag tgaaacgtaa atgacgtttt 792841 ttccttccgc tttgccgaaa tacacgttat tcggcacatc gtaattggct ttcatgtagt 792901 tttctacttc cgttacgtcg ctggaatcgg caagcgcgcg ctggctgttg gacttgatat 792961 tctgtacagc gtcataaatc gtgaaattgt atgttcccaa gtatttcaca agatagttcc 793021 ggtcgaatga tcttgtcagc aattcaggac ggtctgattc cgcaactgcc aggttgatca 793081 agaacacaag aattgaagac gcaaaaataa ttcggaacga ttttttgctt gacgtttcgg 793141 caggcttgtt tactttgatc gccaagatga tcaggatgat cgtatcgata aagtaaaagg 793201 cgtcagtcgg tctcatcagc gaaaatgcgc tgtcaccgag ttggccgccg tttgttttag 793261 cctgcataat gaccggaatt gtaataaaat cattgaaaaa tctgtagtac acaatgttgg 793321 cgtacagtaa aaaagacatt aaaaaatgaa tcactataat ggctgtctgc tgtaattttt 793381 tcttgaacaa gagtccaaag ccaagaaaga acaagcttga gctaagagga ttcacaaaaa 793441 gcaatatttt ttgtatcgtg ttgtctattc ctaagttgaa attcaggaca taaccgacat 793501 acgttttgat ccataacagg acgaccgcaa ttaagaagaa ggccagtcct ctttctttta 793561 taaatgtttt cattgttaca ctcctttttt ccgatccagt tcgagcgaaa cgatagaaaa 793621 aacgaacgta tccaatataa cacgaatcag cagattagaa aagtgaaaat cgtatgaggg 793681 agaaagtggc gaaaaacgcc gtcgaatcaa cgtttcgctt tgatattacc aaatgtaaaa 793741 caaggtatct ttctagaaat aaaggaataa aatggtacat tgagaattgt atgataaaat 793801 ataaggtata gataaaaaga ggtgaaatga tggatttttc ccatattgtg tctgaagata 793861 aaattaagcg cgccatcaaa gacggggact ttcaaaacct cccgggaatg gggaagccgc 793921 tgccgaagga tgacgcggca cacttgccgg aatcgctgcg catgggctat cgtattttga 793981 aaaacgcggg aatggcagag gacgagggcg cgctcaaaaa agagcttatg accatcgacc 794041 atttaatcga aaagtgctat gacgaaaaag aacgcgagca attaatcaga aaaaaatctg 794101 aaaagcaatt gctgcttgat aagcttgtcg acaaaaaagg catgttttca aagccagcat 794161 ccgcttttta taagaataaa gtatatgacc ggcttggacg aaacagacct tcttccagct 794221 gatttgtctt gtctgcagga tggcgattga taaaagccat cctttttatg ttccaagttc 794281 tatgtcaaaa ggtttatgtt tttccatcta tgggaaatga ttcataaacg aaaaaagggt 794341 gatgggatgg aacgactatt agtatggata gagcatatat ctgattggct gtggggtccg 794401 ccgctaatca tcctgctgac ggggacgggc ttgtatttca ctattttgct gaaaggtttt 794461 caatttcgct atcctttata cattttcaaa cagacaatcg gcagtgtagg aaaaaagccg 794521 aagggagaag gcacagtcac accgcttcag gcattgacct cagccctcag ttcaacgatc 794581 ggtgcagcga acattgtcgg tgtgcccgcc gctattatgt ttgggggacc aggagcggtt 794641 ttttggatgt ggcttattgc cttatttgcc atggcgatta agttttctga aagtgttctt 794701 gctgttcatt acagagaaaa aaatgagcag ggtgaatacg tcgggggacc gatgtattac 794761 ataacaaaag ggctgcgcat gaaatggctc ggcgtattct tctctgttgc gctgattgtg 794821 gagctgattc ccagcattat ggttcaggga aattcggttt cagtctcgct tgccgagacg 794881 ttttctttca ataaaatata cgcaggaatc ggaattgcat ttttgattgg gttagtggtg 794941 ataggagggg taaagcggat cggaaaagta acagagtttg tcgtgcctct tatggcaggg 795001 gcatacgcag gtgccggtct cctgattgtt ctcatgaatc tatcatcagt gccggcgttt 795061 ttctctctcg ttttttcaaa tgcgtttacc tcttcttcag cagttggagg gttcgcaggt 795121 gctgcgttgg cggaaaccgt tcgctgggga tttgcccgcg ggctgtattc taatgaagcc 795181 gggatgggaa cagccccgat tgcacatgcg gcagcaatga ctgatcatcc tgtgcggcaa 795241 gggttttggt ctgtgatcgg cattgtcatt gacaccttaa tcatctgtac gactaccgct 795301 tttatcgtcc ttgcatccgg tgtatggaca gggaagaacg cctcaaatga cccggcagca 795361 ctgacaacgg ccgcatttca gcactatttc ggttctggag gaggatactt cgtttcggtt 795421 tccctggtct tctttgtcgt atcaaccatt atggttgtca ttttttacgg cgtaaagcaa 795481 gctgaatttc tgttcgggcg gctggcagga catgtgatta aattcgttta tttagcggct 795541 attatcatag gtgccgcagg cggagcaaaa gccatttggg gcgtattgga cttagcattg 795601 gtttttattg ttgtcccgaa tgtgattgcg ctcttgttat tgagcagaaa ggtaaaagcg 795661 ctgtacaccg aattctttac atctgaacag tactacctga aagatataag aaaaacgaaa 795721 caaaagcctg tttatccaac aaaagaagct aaaaattcct agtgttttgc ttttgcgccg 795781 aacaatgctt tgctttttat gatcaaataa atgagtaaag gcagcaaaag agaaatcact 795841 acattaatga ttggtttgat tctgttaaag tcgattagct gatttgtatt taaaaaaaac 795901 caaaagccgc atacgactga gaacatgccg gttggtgtat acatggcttt cgggtcgatt 795961 tttgagtgta aaaacgaaag gccgtatacc acgatatata gggaacctgc tatcttcacc 796021 ataatgaccg gaatccaaaa agccgcgatg atcaggtctg agcgatccag aaaatccgta 796081 atgcggatct gcctgatgac catataagca ggatcaaaga aagtagatgt caggttggga 796141 ccaaagacag aaattgaaga aaataacatc acggccagca ataaagcgcc cagcagtatc 796201 gcgaaaatgg tgtattttag cgggacgctc cggtttgaga agagaagcgg aaggataatc 796261 aattccccca ttgtcccaaa cgcgtaatag cctgattgaa ggtatgggat tagaccttca 796321 aaaacaggtg tcaagttttg aagctcaatt tgtgtggcca gcgtaaatgg aaggaacaag 796381 accaggatgc cgaatggaaa taggaatatc tgcgccattc tggtcaatgt ttcttttccc 796441 tctctggcaa tacagatcgc cacaaagata ataacaccgc caagaacagc cattggtgtt 796501 ctcgggagaa ataaaatgtt aatcaaattg atgaaaaaac gtatatcatg agcattgatt 796561 aacaggaaat acaaagaaaa cagtaaaatg ataatccggc ctgcgattgg tgaggaatcg 796621 ctcagcagct catagatatt tttatcctga tgctttttca tcagcctatg catgagccag 796681 agtgccggaa tcacgatgac aacgccgagg atgtagctgt gccaggcatt ttgttttgct 796741 gattcgatca tgagaatcgg agcatgcttt aatccgactg ctaacgtata cagagctccg 796801 aaaaataatc cttggtatgc agaggtcttg tccataaagc acatcctttc tgtcatgttc 796861 aaaacggaat atatttaaac aggtgcccca gccgcggaag caggggattc actctcatat 796921 aaatccatag aaaagcactt cctgcaatta gcaggctgaa ggcccatttt gttagattgt 796981 tagcggaacg aaaattcttc cattcatatg cgtatatggc aatgcacaca atcaatgtct 797041 gtacgatata gctgatcatg ctgacgcacc tccattaatg gctgatcgtt ttgtatagga 797101 caccgccctg ctcaatcgtc acaattggga cgacgtgaac ctccatatcc ttatatacct 797161 cttcccattc ctttttcagc agattcttcg tggttgccgt gcttctgatg gtcctgtctt 797221 gaaagccggc cgggtccgcc tttagctttt gcaaacgatg aacggtgctg atcacgtcct 797281 tctttatggt tctgtttaat gctttttgaa tgatgtaata ctggtcattt tctctcgtct 797341 cataggttga ttggttttcc ataataattc ctttggctct gatctcgatt gtcattgaca 797401 gctttccgtt tttttcagcg gcatgaaagg atgcattgga cttttgaagc tgaatggatg 797461 cttgccccat ttgattcggc aggtctacta tgaattctgg ctggcgggct tgattcagca 797521 acatcagggc tgctgtcatg tgttcatctt tgaaaatatc catcaatctg tcctttttaa 797581 agatcgcaag cccgtcaatt ttcaaattag atttgccttt ccctccaggt tttgttttag 797641 atgcagagat gaccggtgca tacggatcac tgcctatttc tactagatca gacatgaatc 797701 tgcttaagaa aacggggcgg ctcgttgcga taatggccag ctcccgaatc atttccgccg 797761 gaaactgttc aagctgaaca tcggtattta aaatgtcccg cgcttctccc cggctgacta 797821 aaatgagcgc cgttaatctg ttctgcggat ttcgcgttaa aatatcaaag actggggcaa 797881 cgccgtctct cgccatatcc tctccaataa tgactgtacg tctgtgggac gtattgattg 797941 tccgtgacaa ggaggtttgc agcttgttgt tcgcttctct gatcgtagtg ccggaagctg 798001 aatcaacata ccatgttttt gaaccggcag ttccgccgcc gccccctgtt tgtccgccta 798061 attggccgac caagggaatc tgcatggcca ctcgatactg atcttttttc ttatcaatgg 798121 ctgagctgac aacaaatgca atgtcattga tttctgtccg gtcccagcac cccgttagaa 798181 ggatacaaat gagaagcggc aaaacacact tatatattgt tttcttcatc ttttgggtcc 798241 tctcttttcg ctcccttctg tccgttgccg cgcgaatacg tgcccggcct tctggtcatc 798301 gtccaccaag gcgccctgac aaaaatatct tttacttcat ctcgtttaaa cggagaaatc 798361 ccggataaat aaggaatgcc gaaagattgc agcttgcata aatgaagcac taagataatc 798421 gtgccgagca taatgccgaa tatcccaaaa atactcgcca aaaacataag cgggaaacga 798481 agcatcctga tggagatagc taagttaaac cgcggaattg taaatgacgc gatccctgtt 798541 aacgatacga tgatcaccat gggggcagac acaattcccg cttcaacagc ggctgtccca 798601 atgactaggg ccccgagaat actgacggtc tggccgatgg ttttcggcag gcgcactccc 798661 gcctcacgga gagcctcaaa agaaatttcc ataatcaatg cttctatgat ggcggggaaa 798721 ggaatcggtt cacgcgcaga ggccacactg aacattaagt ttgtcggcat taagtcctgg 798781 tggtatgtaa taacggcaac ataaatagcc ggcaaatata aagcaacgaa taaaaacata 798841 tagcgaagcc agcggattaa gttagacatc aaataacgct catagtaatc ttcactggcc 798901 tgcataagct gccaaaacgt aatcgggcct gttaagacaa agggcgtatt atctgtgaaa 798961 atggcaaatc ggccttcgag aagctgggcg gcgacggtgt ccggcctttc tgtgtattgc 799021 agctggggga atggcgagta cgtgtcgtct tcgataaatt cttcaatata tccgctttct 799081 aagacagcat caatctttat ctttttgatt cttttttttg ctttgtcaat aacctttgga 799141 tcggcaagcc cgtcaatata ggccaagaca acatcggttt tggttttcgt gccgatttta 799201 aaagagatca ttttaagctg aaacgttttg acgcgaaagc gcacaagagc ggtattgacc 799261 ctgaggcttt cagtgaagcc ctctcttgac cctctgatgg tcgattctgt tatcggctct 799321 tcaatgcttc ttctttgtcc gccttttata tttaagatca ggccttttga gtgcccgtcg 799381 gcaaataaaa ccgcgttccc ctcaatgatg gatgcagcca ctttgctcat actcgtttct 799441 aatgcaacac ttgaaattga tagagtattt tgcagcgcct cttcatgttc atctatttga 799501 tccgtcaaat gcattaagaa agggcggagg gcgtgatcct gaatatgttc agattttaca 799561 attccttcga tataaacaat aaatccgcac agcccgtttc caaagtcaaa ttgtctaaat 799621 acgatgtctg agcagccttc tgttaataag gtcagatttt cgaggttttc cttcaaattg 799681 ggagagatcg gtctgtcctg attgtcttca agctctttga tgagctgaag cgctttgtcg 799741 cgtttattca tagaggctca ccctgctttt taatgtcata ttcaataagt gcttgtgact 799801 tttagggtaa ccttgtctgt ttcatatatt ccagactagg atgaaagcgc tataaaaaag 799861 tgttgactac ctgtatatac aggaatacaa tatgattata agttgtatat acaagttata 799921 aaaacggata cggaggggtt ggcatggggg aactgaacaa atcggcacgt cagattgtcg 799981 aagcagtcgg cggtgctgaa aatattgcag cggcaactca ttgtgttaca cgtttgcgtt 800041 ttgctttaat agatgaaagc aaggttgacc aagagatgct tgatcaaatt gatgtggtaa 800101 agggatcatt ctcgacaaac ggacagtttc aggtcgtaat cggccaggga actgtcaata 800161 aagtatatgc tgaactggtt aaggaaacgg ggattggcga gtcaacaaag gatgaagtga 800221 agaaggcctc agaaaaaaat atgaatcctt tgcagcgtgc tgtgaaaacg cttgcagata 800281 tttttattcc aatattgcct gcgattgtca cggcgggtct tttaatgggg atcaataaca 800341 ttttaacggc ggaaggcatt ttcttcagca caaaatcgat tgtgcaggtt tatccgcagt 800401 gggcggatct tgctaatatg attaacctga ttgcaggcac ggcctttacg tttttgcctg 800461 cgttaatcgg atggtctgcc gtcaagcggt tcggcggcaa tccgcttctc ggcattgtgc 800521 tcggggttat gctcgtgcat cctgatttgc tgaatgcgtg gggatatggc gcggcagaac 800581 aaagcggaga gatcccggta tggaatctat tcggcctaga ggtgcagaaa gtcggctatc 800641 agggccaggt gctcccaatt ttgcttgctt cttatatgct ggcgaagatt gaggtatttt 800701 taacaaaacg cacacctgag ggcatacagc tgctcgttgt cgcaccaatt acgcttctct 800761 taacaggatt tgcctctttt atcattatcg gcccgattac atttgcgatc ggtaatgtac 800821 tgacttcagg gcttatctcg gtgtttggtt cttttgccgc actgggcggt ctgttatatg 800881 gcggtttcta ctcagcgctc gtgattaccg gtatgcatca cacgtttctt gcagtcgacc 800941 tgcagctcat cggttcaaag ctcggcggca cctttttatg gccgatgctg gcgctttcta 801001 atatcgcaca aggttcggcg gctctggcca tgatgtttat cgtgaaggat gagaaacaaa 801061 aaggcctctc cctcacatca gggatttctg cttatcttgg cattacagag cctgccatct 801121 ttggggtgaa tctgcgatac agattcccgt ttatcattgc aatggtcagc tctggcctgg 801181 ccggaatgta tatttcttct caaggtgtgc tggcaagctc cgtcggtgtc ggcggcgtgc 801241 cggggatttt ctcaatcatg agccagtact ggggcgcgtt tgcaatcggg atggctattg 801301 tattgatcgt gccgtttgcc ggaacatacg cgtatgcgag attcaaacat aaataacaag 801361 tggggagcgg gacgtgttga acgttccctt ttcccgtttt caatttaaat atggtggtgg 801421 aaacagatga aaacagaaca aacgccatgg tggaaaaaag ctgtggttta tcaaatttat 801481 ccgaaaagct ttaacgatac gacaggaaat ggtgttggcg atctgaacgg cattattgaa 801541 aagctggatt acttaaaaac gctacaggtg gatgtgcttt ggctgacgcc gatttatgat 801601 tctccccagc atgataatgg gtacgatatt cgtgattatt actcgattta tcctgaatac 801661 ggaacgatgg aggattttga gcggctagtg tccgaagcac ataaaagaga cctgaaagtc 801721 gtcatggatc ttgttgtcaa tcatacgtca acagagcaca aatggtttcg cgaggcgatc 801781 tcttcaatag acagcccgta ccgtgatttt tatatatgga aaaaaccgca ggaaaacggt 801841 tctgttccga cgaactggga atcgaaattc ggcggctcgg catgggagct tgacgaagca 801901 tcgggccaat actatttgca tctgtttgat gtgacgcagg ctgatttgaa ttgggaaaat 801961 gaagaggtca gaaagcatgt ctatgacatg atgcattttt ggtttgaaaa gggaatagac 802021 ggctttaggc ttgatgtcat caacctgatt tctaaagatc agcgctttcc gaatgcggag 802081 gaaggcgacg gccgctcttt ttacactgac gggccgcggg tgcacgaatt tctgcatgaa 802141 atgaacgaaa aggtgttttc acattacgac agcatgacgg tcggtgagat gtcttcaaca 802201 accgtagacc actgcatccg gtatacgaat cctgacaata aagaacttga tatgacattc 802261 agcttccatc atctcaaggt tgactatcct aacggcgaaa aatgggcctt ggcgccgttt 802321 gattttttga agctgaagga gatcctatct gactggcaaa cggggatgca cgcaggaggg 802381 ggatggaacg ctctgttctg gtgcaatcat gatcagccgc gcgtcgtatc aagatatgga 802441 gatgatggcg catatagggt gaaatcggcg aaaatgcttg ctacggccat tcatatgatg 802501 cagggcacgc cttatattta tcagggcgag gagctgggga tgacgaatcc gaagttcact 802561 gacataagct cctatcggga tgtcgaatcg ctgaacatgt atcacgcctt taaggaaaaa 802621 ggaatggctg atcaagatat tacagccatt ttacaggcga aatcccgtga caattccaga 802681 acccccgttc agtgggatgc tacggaaaat ggtggtttta caacgggcac accatggata 802741 ccggttgcag gaaattaccg ggaaatcaat gctgaagcgg cgctgaggga tcagaattcg 802801 gtgttttacc attatcaaaa attgattcag attcgcaaaa tgtatgacat tgtgacagag 802861 ggtacgtatg agataattgc aaaggatgac ccgaacattt ttgcgtatct cagacacggc 802921 agcaatgaaa agctgctcgt gatcaataat ttttacggga cagaggcggc ctttacactg 802981 ccggactctt tagcgcctga cgaatggaag gcagaggtgc tgttgacgaa cgatgaagca 803041 agggaagggc ttcagaacat gacgcttcgc ccatatgagt ccattgttta tcgtttaacg 803101 aaaccgtgtt aaactaagct gggtggtcca taatgaaggt gaataaattc atcacaattt 803161 ataaagacat cgcacagcaa attgaaggcg gccgatggaa agcggaggag attcttccgt 803221 ctgaacatga gttgaccgca cagtacggta catcaagaga aacggtccga aaggcgcttc 803281 atatgctcgc gcaaaacggt tatatccaga aaatcagggg aaaaggctcc gtcgtgctca 803341 atcgtgaaaa aatgcagttt cccgtttcgg gccttgtcag cttcaaggag ctcgcgcaaa 803401 cgcttggcaa agaaacgaaa acaactgtac acaaattcgg gctggagcct ccgtcagagc 803461 tgatccaaaa acagctccgg gccaatctgg atgacgacat ctgggaagtc atcaggtcta 803521 gaaagattga cggggaacat gtgattttgg acaaggatta ctttttcaga aagcatgtcc 803581 ctcacctgac gaaagaaatt tgtgaaaact ccatatatga atatatagaa ggagagctcg 803641 gtctttcgat cagttacgcc caaaaagaaa ttgtagccga gccgtgtacg gacgaggaca 803701 gagagctgct cgatttacgc ggctatgacc atatggtcgt ggtgagaaac tacgtctttt 803761 tggaggatac cagtttgttt caatatacgg aaagcagaca ccgtctcgac aaattccgat 803821 ttgttgattt tgcgcggcgg gggaaatgag agaggcgcct gcctgcggca gcgcgctttt 803881 ttgtttggta tcaaaattga tactatccaa caaaaatgtg cgtactttta ctttttatca 803941 taatggctac aatagagatg agagtaatct aaaggagagg tgttttacat ggcagatcta 804001 aagacacaaa ttctggatgc atacaatttc aggcatgcga ctaaggaatt tgacccgaat 804061 aaaaaagtgt cagacagcga ttttgaattt attttagaaa caggaagact gtctccgagc 804121 tcactcggcc ttgagccttg gaaatttgtc gtcgtccaaa atccggaatt ccgcgagaag 804181 cttcgtgaat acacatgggg cgcgcaaaag cagctgccga ccgcaagcca tttcgtcctg 804241 attcttgcgc gtacagcgaa ggatatcaaa tataatgcgg actacatcaa acgtcattta 804301 aaagaagtaa aacaaatgcc tcaagacgtg tacgaaggct atttaagcaa aacagaagaa 804361 ttccagaaaa acgatttgca tttgcttgaa agtgacagaa cattgtttga ctgggcatca 804421 aaacaaacct atatcgcgct tggcaacatg atgactgccg ctgcgcaaat cggtgttgat 804481 tcctgcccga tcgaaggctt ccagtacgat cacattcacc gtattcttga agaagaaggc 804541 cttctggaaa acggaagctt cgatatttct gtgatggtgg cattcggcta ccgagtgaga 804601 gaccctcgtc cgaaaacaag atctgctgtt gaagatgttg tgaagtgggt ttaaaagaag 804661 aaagctgctc gcatagcgag cagctctttt ttatgcctga ttcgctctat tctgttttct 804721 cctctgatgt aagtacattg ccgttccgag tgcgctgatc agaaatccgg ccaacaggat 804781 cgagtacatg gatgtggctg tgtccggaag caggccgcca gccggaccgt ctgttcctga 804841 tccgcccgaa ccgtttccac cagagccgtt agtcggttga gtgccgggag gcgtatcatt 804901 tcctccgttt ccgtcagttg gctgttttcc gcctggtttg tcggagcctc cgccatgatt 804961 gccgtcatca ccgcctgtcg gttgatctga cgggaatgcc ggcggtttgt tgtttgaacc 805021 ggaatttaag atcgtgtatt cgctgaagtg gtttgtatat cctgtcacca tatcatcatc 805081 gactgatccg tgacctgtct ttgtgaaagc tttctttttt ctatcgacgt gataaatggc 805141 agggttatgg gcttcttcaa tatcaaacat gcgaagcgaa agctgtacgg gctccttgaa 805201 tgattttatt tcttttcctt tttgcttcac tgtaaagtca tatacatctg acagtgacac 805261 atccaattct cccgtagact tgattccgat tgcagtgtct gcggttttaa ggttcgccat 805321 tggcatcttc atgctgtacc agtagttgaa catcgtcaat gaaggatctg actctctttc 805381 tttcaaaagt ttgacctgat cttttttcac tttaagattg ataggcttct cttgagatcc 805441 ttcatgtatt ccataataga caaatggcgt gttggcattt ttagcataaa tcgcaaattt 805501 gtcttcatca agtgtccagc tgccgtcctt ctgctttgtc ggcaggaata cttctttgat 805561 tcgtccttca actttaggag agaccttgtt tcctagtttt ttcagctgtt cggtgaaaat 805621 ctcataatca acgtagccaa ggtcttcacc atgggaggct tctgtaaaga cagaatatcc 805681 gtctcctccg gcaccgacaa aattatttgt tgccacgcgg taggtatcat ccgtatttat 805741 agcaactttg tctccgttag gcgattcaat tttcacttct aacacacggt gtccaggttt 805801 gttgtttaat gtaaaggtat attcgattcc ggccacctga gggaaagcgc cgccgccatt 805861 ttccacattg cttaggcctt gttcaagggc ttctttaatt tgttttccgg ttaaatcggc 805921 cacgtaaagc gtattgccga acggcatcac gttgagcacc tcgccgagtg tgatatcacc 805981 tttgtcaatg cctgctctga tgccgccgcc atttgttatc gctattctgg cgccggctgc 806041 ttctttcgct tttgccagca taccgtccgc gatgaagttt ccgagattcg tttctttcgt 806101 gcgcacatgc tcacgctggc cgtcaagcgc cacatccgtg tagccgactt tttcattttt 806161 cacgtcctct aattcatttt tgaactgatc gagctcttgt tttgcttctg ggttttcttc 806221 tgtatgttca tcaattggca gcacgctcag atttgattta tctgtttgca caacgccttt 806281 ttcatcaaac gcgacatcaa cgcgccccaa gaattggccg tattcttttg cctgcgccac 806341 gatcgtcggt tcttcgttgt tcacgacctc cattttgtct acgagggtgt gagtgtgtcc 806401 gccgatgatc aaatcaatgc cttttacttt tttggctagc tcaagatccc ggttatgtcc 806461 gatgtgggtt aaagcaataa ttttatttac cttttcttct tcttgaatcg ctttgacggt 806521 gttttgtgct gtttcaaagg catcattgaa tacgatgctt ttgcccgggc ttgatgtggt 806581 ggctgtatct tctgttgtca ggccgaatac ggcgactttc tccccgtcaa cgtctaacag 806641 aatgtaaggg tgaatgccgg cctctttctt ttcacctgcc gtaaaggttt gcggcttttt 806701 gacaaatgat ttcagcttgg gctcatttga cacatctacg tttgcactga caatcggaaa 806761 ttccggcgct tcaaagtgat agcggttcgc cggatcaacg gttgcgctgt ttccgcttag 806821 aaaatcagaa agcaccgtcg ggcctttgtc aaattcatgg tttccgaagg tcatggcgtc 806881 atagcccatc atgttcatca ttttcagatc ggccaaaccg ttccatttag taaaatacag 806941 atcgccggaa aacacatctc ccgcatcaag gagaatattg tgatttgttt cgctgcgtac 807001 ttcgttgatt ttcgtcattc gtctcgctgc atcatcgaga tgggcgtgcg tatcattggt 807061 gtgcatgacg gtcagatccc acagtccgtc tttaggagga tctggatttg aatcatcatc 807121 gaattgcagc ttatacacac catagccttc attcgcagac ttgcctacat aagcgacatc 807181 gtctgcttta tcggcaaatg gcttggccaa aagcgaggat tcaaacgtca gattcgtgcc 807241 ggaaacaggc gcgattgacc agttgttgtc tgcttttgga ttgactgttt tttgttcaat 807301 aatgtaatcc atcagcacct gcctattttc aactgcagag ccgtggacaa ttttatcgct 807361 cgtcagatga gggaacccgc cgcctccgga cgcacgatag ttattggtga ctacgagaaa 807421 ttcctggctt gggctgatcg gcttgccttc ataggaaaga ttgatgatac gggatgaatc 807481 cgcattgatc acttttccgt tctcattgta tttagccggt tttgtcacat cgacctgata 807541 tgtgacaccg tcaatcacgt caaaattata ggagcggaaa ttctcgttca gcaaggcctg 807601 gtcgccgcct ttagctggat caatttgatt gaattggcct gctgacatct ccagccagtc 807661 cttgacctcg ctgcctgtca gcttgacgat ttgaacagta ttatcgtaaa gatacaagtc 807721 accgacattt ttaatcgcaa gatctccggc tggaatgttt gtatagtaat tggctccgtt 807781 tctgccgcct gctttaaacg gcgctccagc ggataaaatc ggcaggttct tgtactcggt 807841 atccttcatt tctttttcag cgtaccactt ttgcgcgtca gtcacgatct gaatggaagg 807901 atcatctttg acctgtgcaa agaagctgtt aatatctgct tcggttttgc cgactggctt 807961 tcggacatac tccagtgtgt tttggtgtgt ttgctgaatg gtgtttgtaa cggtttcgtt 808021 tcttgatgtg acgttgccag caatagattc aatacttcct ttggaatctg ctaccttcca 808081 tgagccgtcc gccttttcaa gcttgaggtc aatcacgcct aaatatttgc cccagctgct 808141 tggcatgacg acaggaatgc cgttaattgt tcccttttcc acattgaact gagcaacacc 808201 cgcatactcg gcggaaggaa agagtccgtg ctgatggccc gagataatcg cgtcaatgcc 808261 tttcgttttg gtggcaaggt caaacacggc gttttctgcg cctgatgatt gcgcctgctt 808321 ttcaatgccg gtgtgggcga gggcaataat gacatctgcg ccttccgcct tcattttcgg 808381 gatcgtttca ttggcggatt ctacgatatc ctgcacctga acttgcccct cgagattctt 808441 tttgtcccat gtcatgattt gcggcgggac aaagcctatg tagccgactt ttactttctg 808501 ctcattaccg ttttcatcaa tgagggtttt ttcattaatc acatacggcg tataacggtt 808561 ttcgccgcta gttgttttga cgttggcatt tacaatcggg aaatcggctc ctttgattgt 808621 gccgtcgaga aagtcgagcc cgtagttgaa ttcatgattg ccaagcgttc cggcgtcgta 808681 tttcagcgca ttcatgacgc tgataatcgg atgggttttc gtgccggaga taatgtcgtc 808741 tttttgatat ttcaccgcgt attcacccag cggattccct tgaatcaagt cgccgttatc 808801 cacaagcagg gtgttagggt tttgctcgcg gtgcttttgg atcaattgcg ctgttctcgc 808861 cagaccgaaa tccgccgttt ctttgtcgct gtagtaatcg taatccatca tgttggcatg 808921 aatatcagtc gtagccaaaa tactcagatg cacctgagga gccgcgcttt cttctgcatg 808981 aatgggtggt gttgggagga ttaggctaag tatcataatt gggggcaaaa gaatacggag 809041 aatgttttcg acgtgtgttc gtcttttctg tattctcacc agttctccac ctttcaacga 809101 aatttgtgtt acagctccta ttgtaagaat attttgtaac tatttgtagg tgtttcttta 809161 tgattattgt aaaagggaga aaaatgagta ttatgtagca gtatcaaacg acaaatactg 809221 ggcatttatg cttatcgttt gtcacaatcg cggaatgttt attttagtgt ggctggggta 809281 gagtgtttta tgtagacata taaagcggga ggttatgaat catggggaaa aaaattgcag 809341 ttgttttaac atattatttt gaggacagcg agtacactga gcctgcgaaa gcctttaaag 809401 aagcgggaca tgaactgact gtcatcgaaa aagaaaaagg aaaaacagta aaaggcaagc 809461 agggaacagc ggaagtgacg gttgacgcgt ccattgacga cgtaaattct tcagactttg 809521 atgcgctttt gattcctgga ggattttcac cagaccagct tcgcgctgac gatcgtttcg 809581 tccaatttac aaaagcgttt atgactgaca aaaagccggt atttgccatt tgccacggcc 809641 cgcagctttt aatcaatgcg aaagcgctcg acggccgaaa agcgacgggc tatacgtcca 809701 ttcgtgttga catggaaaac gccggtgccg acgttgtgga caaggaagtg gttgtttgcc 809761 aggatcaatt ggtcactagc cgcacaccgg acgatatacc ggcatttaac cgcgagtcat 809821 tggcattgct tgagaaataa gaaaaaacgg acgctcttgg gcgtccgttt ttttgttgct 809881 taggcttgag cacctgtcag tttcttgtac ctgtaataca agaaagcagc tgcagccgtt 809941 ccgatgaccg caatgccgaa gtcgaatatg aaaatatggg cgatgccccc cgcttttgcg 810001 ataagccctg ttgcaatcgg cagcagaatc gatgcaagac ttgaagcagt cgctacaatt 810061 ccggtaacgg ttccttttcg cttccagaaa agctctgtca ttaacgtaat ggtaatttga 810121 aacacacccg cagttgaaaa gcctaagaaa aaggcagtga tgtccagcac aactgggata 810181 tgaacggtca gcatgactgc gagcgtacat aaagtaataa taggatataa gagcgttatg 810241 aagacaggtt tgacccatct attcagcaaa acggctaata ataaaacaga tgccagagat 810301 cctatactat aatagctcag caattgtaca gatgctgatt cagctaaacc ggctgccttt 810361 tgcgcgtagc tcgggagcca gatttgagaa accgtaaata aagccgtgga tgtaaaaccg 810421 atgataatca gtgcggtgcc ttccttctga aaaacgggtt cagacaagaa aacgggagat 810481 tcctgttggc cgctattagt tggtttctta tgttttttag gaaacgaaag cgttgataaa 810541 taaataatat tcaggagata gaccgctgcc ggcagataaa aagcaaatcc gtaaaacatg 810601 ctgtggtctg ctaaaaatgt gatcaaaagc ggcaaaagtg cggcccccac agacataaag 810661 gctttaacca agacatttgc cgaaccggaa gcagacggaa agagctcggt tagggccgga 810721 tatgttccgg catccatggc tgaattagcg actccggcta ataaagcgaa cacaaacgcc 810781 agctcatagc tcggtgataa aggaataccg actaaaaaga cggccataat tcccgcagaa 810841 gcgacaacaa gcggctttct gccgatttta tctgatagaa cgccggaaat gccgtatgtc 810901 agcagtttgc caaacccgat agcggcaatg acataactga tgccggtcgg atcggtattc 810961 cactgttttg ttaatgaaga catattggat gcgagaatga tgttgaccat ccccagaaag 811021 aagtagttga tatacattcc ggatgctgtt ttgatagatg tcgtttgcat gcttgtactc 811081 cttcaaatct tattcgaaca ctttgctgtt ttggtttggg gaaatgataa aaaagactcg 811141 ccgagtttcc ggccagtctc cattatttac gaagcgaggc taattcttga gcaatcgcct 811201 gcatttcact tgggctgaat gattcttttt tcatcaccat tctgtgaagg tacgtgaggt 811261 cttcaatctt ctcatcactg aaatcctccg ctttgattac gccgacgttc agcatgttca 811321 gcttttggga aatctcttca atcatttgag ttaatgtttc tgtatttggg ctggacaaag 811381 ggttccatcc tttctatgcg caatataggt atgttttatt ctaacagaat tccatcagaa 811441 aaaaacccta ttctaaaagc aggctgttca ttccaaaaaa gtgaagacat cagttgaaaa 811501 gaaaatgaac atcctactaa gatattcatg aaggtttctt tttagagaaa taggggcaaa 811561 gaatagggag gttgcacatc atgataagcg tgttatttgt ttgtttaggt aacatttgcc 811621 ggtctccgat ggcggaagcg atttttaggg acctggcagc caaaaaagga ttagagggga 811681 aaatcaaggc ggactcagcc ggtattggcg gctggcacat cggcaacccc ccgcatgagg 811741 gaacgcagga gatattgcgc agagaaggaa tcagctttga tggcatgctg gcgcgtcaag 811801 tcagcgaaca ggatctggac gattttgatt acatcattgc aatggatgca gaaaatatcg 811861 gaagtctcag aagcatggcg ggttttaaaa acacctcgca tatcaaaagg ctcttggact 811921 atgttgaaga ttcagatctg gctgacgtac ccgatcctta ctacacaggg aactttgaag 811981 aggtctgcca attaatcaaa acgggctgtg agcagttgct tgcatccatt caaaaagaaa 812041 aacaattgtg agtgaaagga gaatttgcat gaacaacgaa cgtttaatgc tgaaagggat 812101 atttctcgga gctgcggcag gcgcggcgtt atcactgctc cataagccga caagacaggc 812161 gtgcgggatg agatggctga catgcaagca taaactttca ctgtacaaaa gcaacccaga 812221 gctgttaaaa aacactgtca tcacaaaagt ggatgaggcc aaaaagctcg cccgaacgct 812281 ttcaaaggaa gtcgactttg tgaaccagca ggtgaaagag ctgaagaaaa caacgccgca 812341 agtgatggaa ctcgtgcaag aaacgaaaga gcatttttca aaaaaatgat caaacatgcg 812401 aggtgagacg acatgagttt tttgaaagag cttttcagca gatacaccct tcatgaagga 812461 caaagtaaat cagcggagct ggcgtatttt tttctattgt cactgtttcc gtttttgatt 812521 tttatgctga cgctcaccgc gtatcttccg ctttctaccg atgatgtttt aggagtcata 812581 gaacaatatg ctcccgccag tgcgatgtca ctcgttgaat ccattaccca tcaaacctta 812641 aataatcgaa atggcggttt gctgtcattc gggattatcg ccgcattatg gtctgcgtct 812701 aatggaatga atgcgatcgt ccggtcgctg aaccacgcgt atgatgtgga agaaaaccgc 812761 tcttttatca ttgttcgtct aacctcgatt tttttgacga ttgccatggt atttacgatt 812821 ttagtggctt tgcttctgcc ggtatttggc cgggagattg gaaggctcgc ttctgacttt 812881 gtcggcgcgt cggatctgtt tttatccgtc tgggccgcca ttcgctgggg tgtcagcccg 812941 cttgtgcttt tgattgtttt ttccgcgctg tatgtgattg cgccgaacaa aaagctgtct 813001 ctccggtttg tcatgccggg tgcggtcttt gcgactatcg gctggatcat tgtcagcaca 813061 ttgttttcat tttacgtcag cacgtttgcg aactatagcg ccacttacgg gagcatcggg 813121 ggaatcatcg ttctgatgat ttggttttac ttgagcggca ttttaattat cctaggcgga 813181 gaaatcaacg ctcttttaca taaacgtaaa aagcttcctg atgaaaatcc ctaccattag 813241 cgcaccctat aaacgaactt cggttcaaaa agaagtcggg gggatatcgt gatgaccaag 813301 catacgaaaa aaggcggaag ccataacaaa caaaactcga aaagcaaatc gagccataaa 813361 acaagcggaa gcgccaacgg acaaaacggc taccattagc ataaaagcct cctgacatga 813421 tgtcgggagg ctttttgatt aagaagatga agaataggtt tcagccggtg accagctttt 813481 cggtttgccc agcacaaggg ccagccacac agagctaagc gtgagagtaa tgaagtagaa 813541 caagtttgcg ctttcaaatg tctgcatata ccagccgccg gcaactgggc cgaggatgct 813601 accgagactg aatgtaatgc cgcaaagcag gtttcccgcc ggcaggaggt gaggcggaag 813661 aaggtctgtc atatagctga tgccaagtgt aaaggttgat ccgactgcca ttcctgcaat 813721 aaaaaagcag ccgccgatca cgtagggcga aggaaataca ccggcgatga aaaagcaaag 813781 agccccagtc agtaaaatca ccagcagcac attccgcctg ccgtatttat cgctgaggat 813841 gccgagcgga aactgaaaga taatgcttcc aatcgcaaat gcgggaagga tgatcgctac 813901 tgcgtctact gatatcccca aacggagcgc gtacaccgga aagcttccgt tcagcgccgt 813961 ttccagaaag ccatagccaa atgtaggcat aaaggcaacc cacccaaaca gcatggcctg 814021 ataaaatcgc ctgaaactat tgtctgattt ggtttcatga ggactggttt ccgggtatgc 814081 attttgtaga aagaaaacaa aaagccacgc aaacagactg atgcagccgg acacgataaa 814141 aggaagcgac ggactcagct tgacaagcgg caccatgaac gggcctgcgg caaagccaag 814201 gccaaaggaa agcccataaa tagacaggtt tcttccgcga ttttgttttg atgacatgga 814261 ggtcacccac gtttgcgtag aaaagtgaag catgtggtcg ccgattccaa tgaacaggcg 814321 aagcaggaac cagacccaaa ctgactgaag ccaaataaat ccgaataagc ttaaaatgac 814381 aatgcttccg cccatgacga tcagcggctt gaacccgagc tttctgagcg gtgcttccat 814441 aaacggcgaa gccaaaagca caccgatata cagcccggtc gcgtgcaggc cgttgatagc 814501 agcggattct ccatttgttt caaaaatgat tgaaatgaca ggcagcagca tgccttgtga 814561 aaacccggaa atggaaacga gcaagacaag gataaagaaa tgaaatcgtg acatcgtgtc 814621 agttctcctt atatggaatc tatgttgatc gtacaacgtt ttccaaaagc aggcaacctg 814681 aaaaaagcct atatcacgct atacatttgc cctcgtgtaa tcatgaaggt ttttgtgaag 814741 aataaaaata aaacaagtca taaaaaagga gctatttcac catgaatcgt atctttttta 814801 ttttagtggc ggccggtgtt ccgctttctg tgattggcag tttgatgcat tggccttccg 814861 cggttctatt tgcagtttat tgcgtgacga ttatcgcgct tgcaagctat atggggaggg 814921 cgacagaatc actgtccatc attgcaggac cgcgtatcgg cggtttgttg aatgcaacct 814981 tcgggaatgc ggtggagctg attatttccc tttttgcatt aaaagaaggc ctgacaggaa 815041 tcgtgcttgc ctctttaacc ggttcagtgc tggggaacct gttgctggta gcgggcctat 815101 cgttttttgt cggcggttta aaatataagc ggcaggaatt taatatccat gatgcccgcc 815161 ataactccgg gcttctgatt tttgccatca ttgtcgcctt tgtgattccg gaggtattct 815221 ctgttggtat gggaaacgcc agcaagctca atttaagcat cggcatcagc atcattatga 815281 ttctgttata tgtggcggcg ctgtacttta aacttgtcac gcatcggggc gtttatcagc 815341 cgaataatgc cgctcagact gaagaagagg aagagccaga atggtcaggg aaggttgcga 815401 cgattgtctt gtttgcggca acgattgtgg ttgcatacat atccgaaaac ctggtccata 815461 cctttcactc ggtggctgaa cagttcgggt ggagcgagct gtttattggg gtcatcatcg 815521 tggcgattgt aggaaatgcg gcggagcatg cgtcagcgat tattatggcc ttcaaaaata 815581 aaatggacat tgctgttgaa attgcagtag gctctacgct gcagatcgct atgtttgtcg 815641 caccggttct cgtcatctgt tctatctttt ttccgacaag catgccgctt gtatttacat 815701 tgcctgagct cgtcgcgatg gtatcagcgg ttctcttgat gatcgcgatt tcgaatgacg 815761 gggattccaa ctggtttgaa ggggcgacac tgcttgctgc atatgtcatt atggcgatcg 815821 gctttttcct tctttaacct gaaaaaatga tggataacaa caaagcggga tgaaaagact 815881 aagggaaaat gccatagaaa gagtgatatg atgaaaaagc tatttcattc cacacttatt 815941 gtgttgttat tctttagttt tttcggcgtt cagcccatcc acgcgaaaaa gcagtttaag 816001 gttcctaatt ctgtcgcaag catttcaaag gaaaacacgt atccgaatgc ttcacaggat 816061 cagccaatgc ttcagccgag caagctggca aaggaattgc tcgatcattc tgaggtaaag 816121 attgaaaatc cgcatctcat caaaatgctg aatgaatcca acatatccgg cacaccgctt 816181 gcagtagggt accgggcgac aatatttctc gggaaatggg cgctcggcta tgaatcaaat 816241 gaaacagtcg caaactggga atataaaaaa atcaatacaa accgtgcgga taaccgcggc 816301 gggaaagaaa cggctgaaat gcattatgcc caggaacagc agtacagagt gaagggcggc 816361 ttgacagcta aagttccaaa tgctgaagat gtcaaaagca tgatgatgca aaaagcaatg 816421 aagaaaacga acctcccgct tgcatttgag acggtcatcg gggctggcac aaaacgggat 816481 cagatttata aagtcgctcc taaaaaaatc ggttatctac atgcatatgc accggctgtg 816541 aatgaaaaag gaaaagtgac ttacggagaa gtgtacttag tgctgaaagg aaataaacga 816601 aaactcgtcg tgaaaaatgt cacgtcacag ggaatcggcg cgtggattcc ggttcaagat 816661 catgtcacgt ttggctttca gctttcctca ctgccaagat aaataaaaaa ctgattccaa 816721 ctcggaatca gtttttttgt ttattgggtt ctctcgattc ggaccgcttc ctcaagcatt 816781 tgcacattgt tttggtagag ctggcgaacg agaacccgtc ttactgcaag gctggcactg 816841 aaataatcat catctttcac catgccttta accgtaaatt cgacgccgcg attgatttta 816901 ttcaatgcgg tgatgccgtg gatttgaaac ggttctgtcg gattgccgaa ttcatcccgc 816961 ttcaatgaat cacgaagctc ttcattcagc atgtcacatg cctcttccaa cacgctgtac 817021 acgcggtccg gatcttcttt aaagctgata agaaaggatt cggtaatccg cataaaatca 817081 atattatagt tctctatttg tctgacctcg ccgttgctga tggtgagcag cttcccgctc 817141 cattcccgga tttgcagcga gcggaggccg atttcctcca ctgtcccgtt gaacaagttg 817201 ttgacggtga cataatcgcc tttgtgcagc tggcgttcat atattaagaa tacaccagcc 817261 agcacatctt tgatcagcga ttgggcgcca aaaccgatca cgatacctgc tacgcccgcc 817321 ccggccaata tcttgccgaa atcatgcaca aataaagaaa taacgtaaaa gataaaacca 817381 attgttgccg tatactgggt gacagaacgg acaaggcttt caatcgtttt ttcctttttt 817441 tcttcaataa agtccgtccg tttaaaaaat agctgtacca gccggttgat gataaagaca 817501 ccgatccaaa ggataacggc aacgaggaga atatcgacga ttttattttg aaaaatctcc 817561 gtaagtgttt ctttcatccg catctaactc ctggcttgac gttttgtgaa gtctgtatcc 817621 tgataataac tgtttttgac aagaacattc ggtccgaggc accggacatt cgggcagtgg 817681 caactcagtt ctttcgcaag cttggtctct ctccactttt cataggcgga agggaggctg 817741 tccgtctgaa tgttgccaag cggcggggta tcaccgaaat cggtcacgat aatgtttccg 817801 tcgaaaatgt tcacattcag gcgggatcgg ccgtcagggt catttcgcac tgtgacgttt 817861 ttcgccgcgc gaagccggcg aagcagcttt tggtcgtctt cgtccggact gcaggcataa 817921 aacggcagcg ttccgaacag catccacgta ttttcatcac gaatatccag caagcggtga 817981 atggcctgtc tcatctcttt caggctgagg gattcaagag cgcttgcgaa atcgcttgga 818041 tacattgggt ggacctcgtg acgctgacat ttcatatctt ctgtgatttg gcggtgaata 818101 tgctcaatat gcggaagtgt tcgtttgttc agcatcgttt ccgcagatac cattactccg 818161 gcatccacga gcgtgcggct gttttcgatc attttttcaa aatagcgcgc gcgctgttcg 818221 aaggtcggtt ttctgtccat catggcaaag ccgatttcag caaaatcttc aactgttccc 818281 cagttatgtg aaatatgtag cacatcgaga tacggaatga tccattcgta ccgctcgatg 818341 tcgagggtca gatttgaatt aatttgtgtc cgcacacccc gttcatgggc atatttcaat 818401 aaaggaacaa catattcttt tactgatttc aacgaaagca tcggctctcc gcctgtgatg 818461 ctgatggatc tgaggcgcgg gatttcctcc agccgtttta acagaagatc tattggcaga 818521 gcattcgggt ctttaggctg caatgtatag cctacagcac aatgctcgca tctcatattg 818581 cacagtgtcg ttgttgtgaa ttcaacgttt gtcagctgca tgtctccgta ttggtcaaca 818641 tccatatagg cttcccaagg gtcaaactcg ggcgtaatcg gacgcagctt cgtgttttgt 818701 gtcatgacta tctaactcct ttataaatgg gcatactaac gctgccaaca gttaatttta 818761 gacctgattt gccaagatcg caagtagcgc ggcgattgaa aaacggcaaa aaatgagcta 818821 ccataataaa aaatgaatgg aggaacagaa tggggaacgc cgtaaacaat aaagatcagc 818881 agattgatta tttaaagaac agacttgaca tgtttatgaa cgtcatcgat tcattagacc 818941 ctgaagcaac cgacgttgaa gatatagaca ggcttatcag catgcttgat gacctggaag 819001 ccaaatacga acgttttaaa aaagattggg aataaaaccg cgtgcccgcc gcggtttttt 819061 tattggcata aagcaacagt ataaaacaaa gtctctatct gtaaaataag aaaaaatgca 819121 gaaggagcgc tggccatgaa gtggatgtgt tcaatatgct gcgccgccgt attgcttgcc 819181 ggaggtgcag cacaggcgga agcggtgccg aatgagccga ttaattgggg ctttaaacga 819241 agtgtcaatc atcagccgcc agatgccggg aagcagctga acagtttaat tgaaaaatat 819301 gacgcgtttt atttagggaa tacaaaggaa aaaacgattt acttaacgtt tgataacgga 819361 tatgaaaatg gctatacgcc aaaagtgctt gatgtcttaa aaaaacatcg cgtaacagga 819421 acgttttttg tcaccgggca tttcgtaaag gaccagcctc agctgatcaa acgaatgtca 819481 gatgagggcc atattatcgg caatcattcc tttcaccatc cggatttaac gacaaaaaca 819541 gctgatcaga ttcaggatga acttgattca gtcaacgaag aggtttataa aattacggga 819601 aagcaggaca acctgtattt gcgtccgccg cgcggcgtgt tcagtgagta cgtactgaaa 819661 gaaacgaaac gcctcggcta tcaaaccgtt ttctggtcgg tcgcttttgt tgattggaaa 819721 atcaacaacc aaaagggaaa gaaatatgcc tacgatcata tgatcaagca ggcgcacccg 819781 ggagccattt acctgcttca caccgtatcg agggacaatg cagaagcgct ggatgacgcg 819841 attacagatc tgaaaaaaca gggctacact tttaaaagca ttgatgatct gatgtttgag 819901 aaagaaatga ggctgccgtc tttgtaaaag agaaagacct ctccttaaac ggagaggctt 819961 ttctttattt tatacattta atcagtgcgg cccagtccag atccccgaag cctttctcaa 820021 tcccgctttc aaaatggctc ttggccagct cggcaagagg aagatttgca gaaacccgtt 820081 ttgcggcggc gagtgccagg ttggtatcct tcagccctaa agacattttg aagccggccg 820141 gctcaaattt ctgctcggcc ataatggttc cgtaattttg atagactgga gaaccaaaga 820201 gcgcgctggc gatttctaaa aattgttttt gttctaagcc gtatttctcc atcattaaaa 820261 aggattcaga taacgcctcc agcatggaca caagcaagaa attaatgctg attttggctg 820321 catttgccgt cttgctttct tcgccgacgt caaatatctg ctggctcagg ctgtcgagca 820381 gaggcttggc agcttgcttt gcttccgccg gtccggctgt tatgatacgg agcgcggctt 820441 tggctgcggc atccggtctg ccaaggacag gagcggcgag aaaaaattgt cctttctctg 820501 catgagccgc tgcgagcttt tctgagaact caacactgat tgtgctcatc gagatgtgta 820561 tgccgttctc tgctaatcct tcaagcagcc cgtcttctcc gaatgtcacg gtgctgacag 820621 aatcatcatc tgcaagcatt gtgatgacaa tatcagcgga ctttgccgcc agccgcggcg 820681 tatcagctgc ctgtgcgcct tctgtgacaa ggtcttctgt cttttgtttc gtccggttat 820741 agacagtcaa ttcgtagcct gcttgaagaa catttcgggc aatgggctgt cccatattgc 820801 cgagtccgat gacagcaatt ttcaatctaa tcactccctg aatatttttt ccattataaa 820861 caatatgaac agaatatgca tagcgatcgg cttacaacaa aaaagaacag ctgctcgctg 820921 tcctcattta aaaatattga accatccttt atgtacaaac caaatcagca ttccaatcac 820981 aagcgcggcc atcaggccaa gtacagcgaa atatccgtat ttccaatgca gctccggcat 821041 aaagtcgaag ttcataccgt atacaccggc aataaaggtg agcgggatga aaatggttga 821101 tacgatcgtc agtgtcatca taatcgcatt catccggttt gagtttagcg tcacgtagct 821161 gtcacgcaag tcggacgtca tgtcacggtt ggattccaca atttcagaca actttaacaa 821221 atgatcatat atgtcgctga aataggcttt cgtttcccgc tgctctttca catggtcaag 821281 gcttaaaatc cggtagagca aatcacgcat cgggataatc gtccgtctca aatgcaatag 821341 gtctgttctg agatcaaaca cctcgttcat cagcgttcca tacgttttgt ggggacggct 821401 ttcttcaatt tcattcagcc ggtcttcaat tttatacacg agaggaaaat attcatcaac 821461 aagctgatcc atgatcatat aagaaatatg cccgggccct tttttcaata tgtccggtga 821521 agcatacaaa cgctcccgga ctttagcgat accgggcgtt tcgtgtaaat gaaaggtgac 821581 gacaaatttt tcgccttgaa agatatcgac ttcctccgtc tcaagtgttt ccttattcag 821641 cgcatgaatc acgtaaaaac gatagccgtc ataatggtca agctttggcc gctgcatatg 821701 ctggaagcaa tcctcaatgg caagcgggtg aaaatgaaaa aaatctctca ataacgccgt 821761 ttccgtatcc tccgggccgt aaaaatcaac ccagtaccat gcaatatcag gctgttccac 821821 tcgttcgatc ggtatatttt tcagcagctg atgctctgtt gtgattgcgg taatgttgat 821881 cataaacaac cctccacctg ccattatatc atgcggtctt tatgagaaaa gtatacggta 821941 ctctctgcct aattccagcg gcatgttata ctgaacaaaa acggaaaaaa gggtggatct 822001 catgtggaag gaaaaagtat ctgtcacgcc tccgtatcat tttgaccgcg tgctggacag 822061 gctgtcttta gaccccctca atgctgttga tcgagaggcg agggaagtcc gtgtgccaat 822121 cagaaatcaa gcgggggacg tatgtattgt aaaggtacag gcgttaggcc atgcgggcga 822181 gcctgagttc ctcgtcagcg gggaaacgga tcagggagaa atgatgaagg aaatcaagcg 822241 gatttttcaa tgggaaaatc atttgcagca cgttctggat catttttcaa aaacgagcct 822301 gtccgccatt tttgaagagc atgccgggac gccgcttgtt ctggactaca gcgtgtacaa 822361 ctgcatgatg aaatgcatta tccaccagca gcttaatctt tccttcgctt acacgctaac 822421 agaacggttt gttcatgcgt ttggcgagca gaaggatggc gtgtggtgct atccaaagcc 822481 ggaaacgatt gcggaactcg attatcagga tctgcgtgat ctgcaattca gcatgagaaa 822541 agcggaatac accattgata catcaaggat gatcgcagaa ggcacactca gcttgtcaga 822601 gctgccgcat atggcggatg aagacattat gaagaaactg atcaaaatca ggggtatcgg 822661 cccgtggacc gtgcaaaacg tcctcatgtt cggacttggc cgtcccaatt tattcccgct 822721 tgccgatatc ggcctccaga atgccatcaa acgccacttt cagctggacg ataagccggc 822781 aaaggatgtc atgctggcga tgagcaagga gtgggagcct tatttaagct atgcgtcttt 822841 gtatttgtgg aggagtatag aataattcgt ctgacaatga aggaaatcct gcaaacgtgt 822901 tatactagaa agatgtgaaa aaaccatttc actttctgcc atccgcagaa agcttcatat 822961 agaaacggag agaacaacgt gaaccaacaa aagaaacagg cgcccgtcga actgaaggtc 823021 ggacaaactt ttccgctgac gattaagcgt ctcggcatta acggagaagg tgttggctat 823081 tttaagaaaa aagtcgtctt cgtgcccggc gcgcttcctg gcgaagaagt tgttgtgcag 823141 gccacaaagg tccagccgaa gttttcggag ggccgcatta agaaaatccg caaggcatct 823201 gagcaccggg tggcaccgcc ttgccctgtt tatgaacaat gcggcggctg tcagcttcag 823261 caccttgcat acagccagca gcttcgggaa aaacgtgata tcgtcattca gtctcttgaa 823321 cgccatacga agtttaaagt tgaaaacatg gaaatcaaag aaacgattgg catggacaac 823381 ccgtggaatt accgcaataa aagccaattc cagatcgggc gctcgcaaag cggcagcatc 823441 atcgccggct tatacggcct tgattctcat gatatcgtgc cgattaaaga ctgtatcgtt 823501 cagcatccgg caacgaacaa aacaacaggc atcgtccgcc gcattttaga ggacttcaat 823561 gtgtctgttt ataatgaaag aaaacgaaaa ggcgacgttc gcacgatcgt gacgagagtc 823621 ggctttgaaa caggcgaagt gcaggtcgtg cttgtaaccg caaaagaaac gcttccgcac 823681 aaggaagaaa tcgtcaaagc gattcaaaag cgattgccag aggtcaaatc cattattcag 823741 aatgtaaacg gggcgaaaac ctcagtgatt tttggtgaga aaacaaaaca gctcgccgga 823801 aaaacagtga ttcaagaagt gctcggcgac gtatcttttg aattgagcgc ccgcgctttc 823861 ttccagctca atccggaaca gaccgtcaag ctgtatgatg aagtgaaaaa agcggcgcag 823921 ctgaccggaa aagaaaaagt cgttgatgcg tattgcggcg tcggcactat cggcatgtgg 823981 gttgcggacg gagcgaagga agtccgcggc atggacgtca tcaaggaatc aattgacgat 824041 gctaagaaaa acgccaaaaa acacggcatg gcaaatgcca catacgtaac aggaacagcc 824101 gagcactggc tcccgaaatg gacgaaagaa ggcttccgcc cggacgtcgt cattgtagac 824161 ccgccaagaa cgggctgtga cagcacgttc ttggacacga tcaaaaaagt caaaccgaaa 824221 cgctttgtct acgtttcctg caatccatcc acgcttgcga aagatttgca gacgctgtcg 824281 aaggactatc gcgtggacta tattcagcct gtcgatatgt ttccgcagac ggcgcatgtt 824341 gaagcagtgg cgaggcttgt attaaaatcg tctaactaaa aagaacattt cccagtcata 824401 aaatagtttt cctaataaga cctggatttc ggtaaaataa acaattccga tttccgggtc 824461 tttttcgtgc gcagctcttg tcctaacggt ctgttctcaa ttttatcttc cttcttttcg 824521 cggagatctt tattttaact ggcgaaaaga attgaaaaaa cgtgttgaaa agcaggtgaa 824581 aaaaagcgtt atttaaccgg aaaaatatcc tcccagtatg tttaaaatac atgagtagaa 824641 tgatgtaaaa tcatagatgt attttcataa tttgtaaaat tatatattga cttgcagtta 824701 ttacgtgtga aatattgatg ataggaatat aaggaaagta tggcgtatat catttcaaga 824761 gtcattcgat gtaaaaagtt gaaacattgt aataaatgaa agaggtgaaa atgatggcca 824821 accccatttt aaaatgcata acgtatgagc actacaacaa ttaaataata gtgccgagac 824881 gataacaact attacagtaa tacctacaat ggttatatcc ttgcgacaat catgcttcat 824941 aatataatga ttttagattg acacttggct aaaaagtatt gcagagaagg aaatggataa 825001 ttaaatggat aaagtatata aaagaagttg gtttcaaaca tttttggcat ttttagtatc 825061 tcagctttat tttaattttg tagaattaac gggatggggt cctaagtata gagaaatgaa 825121 tggattccca gcaaacatag ttgaactaga tttctttcaa acatatcttt cattctatga 825181 taatccatgg tttaatatta ttactgtttt cttgggagtt ttcactatta tacaaataat 825241 tacagggata acaaaggata ttcgaaatta aagcaataac ttctgatgcc ttatttaatg 825301 atgaaagaaa atgtacactt tcttaattat cttatgagtg aagactgcga cacttagtca 825361 gcagtctatt ttatggttct ggatcaggat taccgaatta taaccctata caaatatata 825421 gtaggttgcc acttgctgcg ttggttattt tctaaatcat gagcaaatcc caaatgattc 825481 agattgaagt tcttgaattc ttttaaataa gggtttattt tctcttctca tcctctttac 825541 tccatgtgat tcacaagtgg tagcagctta agtaggtttt ttcattctct tgagtactca 825601 gttataccac ccccaactca atttgcttta tctctattag tttttccgca aatatgatat 825661 agagatacgg atatggtgta gtgttaaata tcttatcttc aataacaggg caattatttt 825721 gcgttggtaa tatggagaac tcatatgata ttctatttag gttggaatcc tttttatcca 825781 aaaagttcaa aagcaaggcc actaagaaag acgaaggtca gcgccagtta accagaatat 825841 aaaaaatagg gtagataatc atcccacgtg aaatcttcaa aatttactat agattgataa 825901 gaaatgcttt cgcatgcgat aagtgtaaaa gaagcatggt cagtttttaa tttgggataa 825961 aggttcagcc gtatcccata atgaaaggat ttgatttttg ttatgacaga aaatttctgg 826021 cgtgaattac cacggccgtt ttttgtactg gcaccaatgg aagatgtgac agatgttgtt 826081 ttccggcatg tagtaagtga agcaggcaga ccggatgtgt tttttacaga gttcacaaac 826141 tcagagagct attgccaccc ggatgggaag gatagcgtgc gcggccgttt gacttttaca 826201 gaggatgaac agccaattgt ggcccatata tggggagata agcctgaaaa cttccgtaaa 826261 atgagtattg gcatggcaga gttaggattt aaaggactag atatcaatat gggctgccct 826321 gtgcctaatg tggcggggaa tggaaaggga agcggcctta tttgccgtcc tgcagttgcg 826381 gcagaattaa tacaagctgc aaaagcaggg ggattgcctg taagcgtgaa gacaagactt 826441 ggatacacgg atgtggatga atggcgcgag tggctgacac acattttgaa acaggatatt 826501 gcgaatcttt ctattcatct gcgtacaagg gcagaaatga gcaaagtaga tgcgcattgg 826561 gagctcatcc cagagattaa gaaacttcgt gacgaggtgg caccagatac attgctaaca 826621 ataaacgggg atattcctga ccgtcaaact ggcttgaaac ttgctgaaca atacggcgtc 826681 gatggaatta tgatagggcg cggtattttt acaaatcctt tcgcttttga aaaggagccg 826741 aaagagcata gcagcaagga attgcttgat ctcttaaggc tgcatctgga tctccatgat 826801 gaatattcaa aagaagaagc ccgtccatac aagcctcttc ctcgcttttt caagatttat 826861 ctccgcggat tccgaggggc aagtgaatta agaaatcaat gcatgaacac aaagtcaaca 826921 gatgaagtgc gtgcattgct cgacgacttt gagagaaagt atcttgatgg gatagagtaa 826981 cagcagtgct tgattcaaaa aaggctaaca aaataaaggg atttttacac aattcttgac 827041 taaaataaac ctggattttc ggtaaatccg ggtctttttt gtacgcagct tttactcagc 827101 ctgtcttttc tctaatttat tgtaagaaaa taatggtata tttagtggag atatcatata 827161 aagggggaga ggaaaatgaa acggctatgc atcatcccct gcggcaagaa aaaaatctgg 827221 gatgtccagc ctgatgccgg gccggtaaga gcagaggacg cttatctcag cccgtttcat 827281 caggcgtgcg agcggtatgc aaaaacattt ttcgatgagt gggtgatttt gtcggcgaag 827341 cacgggttcc tccgccctga tgatctcgtt tcgggaaatt acgatgtcac ttttggcacc 827401 ggtcatccgg aaatcatgac agcggacgag ctgcgccgtc aatttcacga aaaaggcttt 827461 tctgatatcg aagagctagt catgcttggc ggaaaaaaat atcgaagcgt tctaaacgcc 827521 gtcatcggag aacaccagca tatcagctgg ccgctatcat catacaaagg cataggctat 827581 atgctccaag cgctgaaccg ggctgttgaa gaaaagcatg aactgtagca cgtacatatg 827641 aggaaaagag tgggaacatg aaaaaacttg tgtttggctt gcttgccatt gtgttattcg 827701 gatgcggact atatatctat catgtatggt tcggtgatcc attttcgaaa aatgctgcag 827761 aacagaagct agtgtcttat gtgaaacaaa cctatcctaa gaaagaaatc aagatcacga 827821 atggggtata taacgctaaa acgtctgaat atgtatttga agcaacctcc caatctcatc 827881 gctacccaat gtgtacgaag ggatttctgc atcctaaagt aacgtgcgat ggaattgaag 827941 aagcgtatac cgaatcagta gcaaaacatg taaatgaaga agcaacgaag gcaatcgaag 828001 cagatctgaa aaaagcggtt cctcgattta taaaagctga tgctgctttg agtatcgaaa 828061 acggacagtt cacgttagat acaaaatgga acaaaaagct ggctgaaaaa gcgcctatga 828121 gcatgacgat tcagttagac gccagcgggt tatcaaaaac agatgccgca aagatggcgg 828181 aaacggtcag aaaaacgctt aatgaaaagg gatatacata ctcaaacggc acgatagact 828241 gtatgcagaa ggacggggac ggcggtattg gatatgtcaa atattcaatt gattttcttt 828301 caaaagcagc tattcagtca aacgatgcag aggaactagg aagttaaaaa gatttccaag 828361 gaaataaata cgtcgatcat tgtcaaaggc cgggtgatat ccggtctttt ttttgcatgc 828421 tgtaaaacga gacaaatgaa tcagtttgag acaaaacgag acacacgtct caaactgtct 828481 ccaaagtgaa gatgagaaga ctgattttac gggctcaaaa gactggcaca cttcttgcat 828541 ttataatggt gaaccctaaa tagaaggagg cgcacaaaat gaaattgtta aaacgagaag 828601 gcttgtcatt aactgaggaa aaagcgctgt ggatgtacca aaagatgctg gagatcaggg 828661 gctttgaaga caaagtgcat gaactgttcg cccagggagt gcttcccgga ttcgttcatt 828721 tatatgccgg tgaggaagcc gtggctgtag gggtgtgcgc tcatttacat gatggcgaca 828781 gcattacaag cacccacagg ggacatggac attgtatcgc caaaggctgt gacctggacg 828841 gcatgatggc ggaaattttc gggaaagcga ccggattgtg caaaggcaag ggcggttcta 828901 tgcacattgc ggatcttgat aaaggcatgt taggcgcaaa tggaatcgtc gggggcggct 828961 ttacgctcgc atgcggatca gcgctcacgg ctaaatataa acagactaaa aatgtaagcg 829021 tttgcttttt cggggacggg gcaaataacc aaggtacctt ccacgaaggg ctgaatttag 829081 cggctgtatg gaaccttcct gtcgtatttg ttgctgaaaa caacggctat ggcgaagcta 829141 ccccatttga gtacgcatca gcctgtgatt caatcgccga tcgggcggct gcttataaca 829201 tgccgggggt tacagttgac ggcaaagata ttttagcagt ttaccaggca gccgaggaag 829261 cgatagaaag agcaagaaac ggcggcggcc cgtctttgat tgaatgtatg acctacagaa 829321 actacggcca tttcgaagga gatgcccaaa cctataaaac gaaggatgaa agagttgagc 829381 accttgaaga aaaagatgcc attcaaggtt ttaaaaacta ccttttaaaa gaaacagatg 829441 ctaataagct gtcagacatt gaacagcgtg tcagcgaatc gattgaaaaa gccgtctcgt 829501 tcagcgaaga cagcccatat ccaaaagatt cggagctgct gacagatgtg tatgtgtcat 829561 atgaaaaagg aggaatgtaa gagatggcga gagtcataag catgtcagac gcgatcaatg 829621 aagcaatgaa gcttgcgatg agaaaagacg aaaatgtgct tttgatcggt gaggatgtcg 829681 ccgggggagc ggcggtcgat catttgcagg atgatgaagc atggggcggt gtattagggg 829741 tcacaaaggg actcgtacag gaattcgggc gtacaagagt gctggacact ccgatttctg 829801 aggcaggcta tatgggagcg gctatggctg cggcatcaac cggtttgaga ccgattgccg 829861 agctgatgtt taacgatttt atcggcacgt gctttgatca ggtgatcaac caaggggcga 829921 aattccgtta tatgttcggc ggaaaagcgc aagtgccgat taccgtccgc accacatacg 829981 gagcagggtt ccgggccgct gcccagcatt cacaatcgct gtatggcctt ttcacgagca 830041 tccctggact gaagacagtt gttccatcca atccgtatga tgccaaaggt cttttgcttg 830101 cagcaataga agataatgat ccggtgtttt tctttgaaga caaaacgtcc tacaacatga 830161 agggcgaggt gccggaagat tattatacaa ttcccctcgg aaaagcggat atcaaacgcg 830221 aaggcaatga tgttacgctc tttgcagtcg gcaagcaggt caatactgcg cttgaagcgg 830281 ctgcacagct ttcagagagg ggcatcgaag ccgaggtcct tgatccccgc agtctgtctc 830341 ctctggatga ggatgcgatt ttcacatcgt tagaaaaaac aaaccggctg atcatcattg 830401 atgaagccaa tccgcgatgc agcattgcca cggatattgc tgcgcttgtc gctgacaagg 830461 gctttgattt gcttgatgcg ccgattaaac ggattacagc gccgcataca ccggttccgt 830521 tttcaccagt gcttgaagat caatatttgc cgacaccaga taaaattgtc agcgtcacgc 830581 ttgaattgct tggcgagccg gcattgaatt aaagggggga cacaaatggc ggtaaaagta 830641 gtgatgccaa aattgggaat ggccatgaaa caaggggaag tatcgatatg gaataaaaaa 830701 gtaggcgacc cggttgaaaa gggagaaagc attgccagca ttcaatcgga gaaaattgaa 830761 atggagatcg aagcgcctga aaaaggaacg ctgatcgata tcaaagtgaa agagggagaa 830821 gaggttccgc ccggcacagc tatctgctat atcggggacg ccaatgagtc ggtgcaggaa 830881 gaggcggggg cgcctgttgc tgaagacaat atgccgcaag ccgtccagcc cgtcaaacaa 830941 gaaaacaaac ccgcagcctc caaaaaagat cgaatgaaaa tatctccagt cgccaggaaa 831001 atagcagaaa aagcaggatt agacctaaaa caactgaaag gaactggacc aggcggacga 831061 atcgtgaagg atgacgtaac aaaggctctt gctgaacaga aaaaagatca agcaaagcct 831121 gtttcggagc agaaagcgca ggaaatcccg gtgacaggca tgagaaaggt catcgctgcc 831181 cgaatgcagg aaagcctggc aaacagcgcg cagctgacga tcacgatgaa agctgatatc 831241 accaagcttg ccactcttca aaaacagctt tcaccaactg cggaagagag atacggcaca 831301 aaactgacga tcactcattt tgtctcaaga gccgccgttc tcgctctgca agctcaccct 831361 gtgctgaaca gcttttatca aaatgagcgc atcatcacac atccccatgt gcaccttggt 831421 atggctgtag ccttggaaaa tggcttagtg gtgcctgtca tccgccatgc tgaaaagcta 831481 tcgctgattg aactggctca atccatctca gaaaatgcca aaaaagcacg cgagggacgt 831541 gcgggaagcg aagaactgca aggatctact ttctccatta caaaccttgg cgcgtttgga 831601 gttgagcatt tcacaccgat actaaatccg ccggaaacag gcattctcgg catcggagca 831661 agctatgaca caccggtgta tcaaggggag gagatcgtca gaagcacgat cctgccactc 831721 agcctgacat ttgatcacag agcgtgtgac ggcgcccctg ccgctgcatt cctgaaggcg 831781 atgaaaacat atttggaaga acccgcagca ttaattttat aggaaaagca ggtgaaaacg 831841 acatgacatt agccattatc ggcggcggac ctgcaggcta tgcggctgcg gtttccgcgg 831901 cacagcaggg cagaaacgtg ctgctcattg acaaaggcaa gcttgggggg acctgcctga 831961 atgaaggctg catcccgaca aagtctttgt tagaaagcgc aaacgttctt gataaaatca 832021 agcatgccga cagctttgga atcgaacttc cggcaggtgc gatatcagtc gattggagta 832081 aaatgcaaag ccgaaaacaa caggttgtca gtcagcttgt ccaaggcgtt cagtacctaa 832141 tgaagaaaaa tcaaatacag gttgtaaagg gaacagcctc ctttctttct gaaagaaagc 832201 tcttgatcga aggagaaaac ggaaaagaaa tcagagaggc ggaccaagta ttgattgcct 832261 ccgggtcaga gccaatcgag ctgccttttg ccccatttga cggcgaatgg atcctcgaca 832321 gcaaagacgc gctttctctt tccgagattc cgtcttcact agtcattgtc ggcggcggtg 832381 tcatcgggtg tgagtatgca gggctgttcg ccagattggg atcgcaggtg accatcattg 832441 aaacagcgga ccggctgatc ccggctgaag atgaagatat tgcccgtctc tttcaggaga 832501 aacttgagga agacggtgtc gaagtgcata cttcatccag attagggcgg gtggatcaaa 832561 cggccaaaac ggcaatatgg aaaagcggtc agcgagagtt taaaacgaag gccgattatg 832621 tgctggtggc gatcggcaga aaaccccgtc ttgacggatt gcagctggaa caggccggag 832681 ttgatttttc tccaaagggc attccggtga atgggcacat gcagacgaac gtgcctcata 832741 tttacgcgtg cggagatgct atagggggca ttcagctcgc gcatgccgct ttccatgagg 832801 gcatcatcgc tgcttctcat gcttccggaa gggatgtcaa aatcaatgag aaacatgtgc 832861 cgcgctgcat ctatacgtcc ccggaaatcg cgtgtatcgg aatgacagaa cgacaggcaa 832921 gaagcatata cggggatgtg aagatcggcg aattttcatt ttccgcaaac ggcaaggcgc 832981 tcattaaaca gcaagcggaa ggaaaggtca aaatcatggc tgaaccggaa ttcggcgaaa 833041 tcgtgggtgt ctcgatgatt ggcccggatg taaccgagct catcggccaa gcggcagcga 833101 tcatgaatgg tgagatgacg gcagatatgg cggagcattt tatcgccgcc catccgactt 833161 tatcggaaac attgcatgag gcgctgttaa gcacgatcgg ccttgcggta catgcataat 833221 aaaggaaaaa gcaggcgcat ggatataagg cgcctgcttt tttattgttg aaagcgcttt 833281 atttttcccc tacaatagat gaaaacggcg tgtaagggag gagcgatcaa ggaaatgaat 833341 tcggtcccaa acgatttgca aacctggaaa cgttttgtga aagacggtgt gcttgacgaa 833401 gcccgattaa gaaaacggat tgcagagtca tggcatcgct gcaaaaaagc tgaggtcaat 833461 ccttatttag aaaaaggccc gaaggtttta cagcaaacgg agctggatca gcagtcaaaa 833521 aaacattcat tcttcttgac gaccgcaaag ccttacctcg aaaaactgct gcctgccata 833581 aaagaaatgg aaatgatggc gctgttaatt gattcagacg gtgttgttct ggcattggac 833641 ggccatccgc gcgcgctcta tgaagccaaa cgcatcaatt tcgtcgaagg ggcatgctgg 833701 acagaaacgg ctgtcggaac aaatgcgatt ggcacggcgc tccacatcag cgagccggtt 833761 gcaatacaag gatcagagca ttactctatc gcttcccatc tttggaactg ttcagctgct 833821 ccgattcacc atgaggatgg cagccttgcg ggtgtaattg acatatcatg cccggcggca 833881 ggcgcgcatc ctcatatgct tggtattgcc acggcgattg cctatgccgc tgaacgggaa 833941 ctcgcagcta aaagccgtga gaaagagctg gagctgatca gccgttttgg ggagagagct 834001 gcatccagtg tgccgatggt gctctgtaat accaagcagc acatcatcag tgcgagcatg 834061 ccgattcgaa cctcaatgcc ggattggcag ggccggcacc tgtacgagtt gaaggaacgg 834121 ggctattcaa tcgaaaatgc tgtcaccata ggagatggcg gcacttgttt ttatctttcg 834181 gaacaaaaga aaaagaaggc gtttcgattc aatggagtga tcgggcaaag cggccgatcg 834241 caagcgatgc tgatgcacct tgaacgagca gctgcgacgg atgcatcggt ctgtttgtcg 834301 ggtgaaacgg gtacggggaa ggaggtcgcg gctcgcgcgc ttcatgagaa cagtgagaga 834361 cggcacggtc cgtttgttgc tgtcaattgc ggagcgattc cgtctgattt gattgaaagc 834421 gaactgttcg gatatgcaga gggcgctttt acgggagcga aacgaaatgg ctataaaggc 834481 gcctttcaaa aagcgaatca aggcacatta tttttagatg aaatcggaga aatttcccac 834541 tcgatgcagg ttgcactttt acgggtgctt caggaacgca agataacgcc aatcggcggg 834601 acgaaagaaa ttccggttga tatcagagtt attgccgcca cacattgtga tttacgcgag 834661 cttgccgaaa acggaaaaat cagagaggac ttgttttacc gtcttcatgt ctatccaatt 834721 gaactccctc cattacgcga tcgcaccgag gatatcccgg atctctttga gtactacaaa 834781 cagaagaatc attggccagg cgatcttcct tctgattttt gtaatgtgct gaagcaatgg 834841 aagtggccgg ggaatatccg cgagctgttt aatgtgtttg aacgtctttc tatcagattt 834901 ccggacggcc ggctgagaga tgaatcgctt cccgctttac tggaagccgc tggattgccg 834961 gccagctctg cagaaaaaaa gccggctgct gccggcgtgc ttacttttcg tgagcaaatc 835021 caaaaggata tgatgatcaa agcgcttgaa tctgcaaaag gaaacgtctc tcaagccgca 835081 aaaatcagcg ggatcccccg aagcactttc tacaaacgcc tgaaaaaatt caacttgtcc 835141 gctgaatcat aaagcatact tccttcagga aatggaaacg ttatgtattg aaggagggtg 835201 ttacgatgaa tattcaaagg gcgaaagaaa ttgtagaatc tcccgacatg aagaaagtaa 835261 catataacgg cgttcctatt tacattcagc acgtaaatga agaaactgga acagcaagaa 835321 tttatccgct tgacgaaccg caagaggagc atgaagtgca gctgaacagc ttaaaagagg 835381 attaaacaaa aatggcccgc ttcataagca ggccattttg ttatccgcgc ggcgcaaata 835441 aaataacaca gacaccgatg agacaaatga atgcgccgat ccagtcatac agatcaggtg 835501 ttttccggtc aacaagccat ccccacagga ccgcaagcac gatgaatact ccgccataag 835561 cggcgtatac acggccgaaa gatgggaagg actgaaacgt cggaagaatg ccgtatacaa 835621 tgaggatcag cgccccggcg attccgtagc cagctggctt tgcctctctc agccatagcc 835681 aaaccagata tccgccgcca atttcagcaa gccctgccgc gagaaataaa agaatggtaa 835741 tcagcatcat gagcactcct caatttgcat ttatctttca ttatagagga ggagagcttt 835801 taaagcttcg gatgattctc aaattccttc aaatacgctt ttcgctgaac ctctgtaaat 835861 tggctgatcc aattgttttg agcctcttca ttcaaatggg gaaggatata gcgttcaacc 835921 gcttcgaaaa acagcggatt cgtgatgatg ttccaggtcg ggattcgaac gattttgccg 835981 tctgttttct cgatgataat atcctcaaaa aagatccctt tcaaactgta ttgatggcgt 836041 cccatataaa gccgcttcac ctcggaaaac agcacgctgc gctttctcaa gaagatttcg 836101 ccactaggtc cggtctttat ggtgaaaatg acatttccac ggcttgtgaa cgcaggaaaa 836161 gccataaaga atgtgatcaa tccataaatc atcgccagta atccgccgcc caaataaagc 836221 agggcatatt tagattcaaa cgtgagggct tcagacacca gccagactcc cacaataaag 836281 gcgccccctg tagcgaggaa cagccaagcc cttagaaaca tcatgctttt tacttcaatc 836341 atgtgctgcc cctaaagctt cggatgattc tcaaattcct tcaaatacgc actgcgttgg 836401 atgtctgtaa actgtccgat ccaattgctt ttcgcctctt cattcagatg tggaaggata 836461 tagcgttcaa ccgcttcgaa aaacaacgga ttcggaatga tgttccaagt gggaatgcga 836521 atggtcttct gatccacggt ttggatcaat atatcttctt ggaagattcc ttttagacta 836581 aatttatggc ggctcatctc aattttcttg atatcagtaa acgtaacaga cactttgtca 836641 gtgaacactt ctccattttt tcctgtcttg atgcggaaaa tggtatttcc ccgcggggtg 836701 aaagccggaa agaagatgat aaataaatat aaacaaaaca aggtgaacag aaagccagca 836761 ggaatggcta ataggtaata tttcgtttga aacgtaatac ccatataaaa gagccacaaa 836821 catgctaatc ccataccggc agatccgaca aaagcccata ttctcaggaa cattttgctt 836881 ttgacttcaa tgatttcttg gtttttcaat gcttttctcc ttttgttaat tcaattctta 836941 tcattttgaa atgatttgat ttacaacatc cttatgagca gggaggatag aaaattcatt 837001 ctgggtgatg cctgtgacaa gccaagtatg gtgggccccc ggcaggacga atgccatgtc 837061 agccacttca ggagtgttat cttttccata tgccagacgc ataagtgtat ccattttccc 837121 tttccgcaaa gccagatcat ttgcaaatcg ggtaacgtcc tcttggtggt catgtttttc 837181 aaggaactct tttagatatg aagggttgtc tgaagcgccc tccaagagtt tttcaaattc 837241 atttgatgtc aatgttacaa tcgattctct tttatcctct gtatctatta tatgtaaaaa 837301 ctcatctgtc ttagcaagta acccttcact tgattccatt tttgtaatgc gatggacttg 837361 ttcatcaaaa aggagttcgt gagagtaggt gccgaatttt gatacatggc atgacacatt 837421 ctgttcggca ccttgcccgt taaatttaga aagcttcact gtatagtcag cgtcgtttaa 837481 tacatggata aacggacagt actcgtcctt taaccgatat tgatggttcc gatattccgc 837541 tgcatccttg gctaagagtg agcggcacgc ggcttcaaat aaggcgccga gctgttcatc 837601 ttctatttcc ggaaaatagg cctgcttcaa ggccattccc tgttcaaaaa acccttcgct 837661 gtaaaagcaa aacaagagtt cttctatgct aattgtaaac tgcttcattg tttattctcc 837721 tatccaaatg aaaatttccc tttaaggaaa tgggttgcgc cgtgtataag cgaatccgct 837781 gttttctttg ctttttccat tccttttttc gcgctgtcta tccctttatg tatcgattta 837841 ttcgccgcat ctatgccgtc attcactgat ttgacgactt tgccggctga ttccagccct 837901 tttttggctg tatcaacaac agcatggatc ggttctttca gctttaaggc tgctttttca 837961 gcaaaaccgg ctgtatattt ggcgatttgt tctccgacga ctccgccaat gtatgaacct 838021 gctgccccaa gaaggacagt acccacaggt cctgcaaagc ttccgattgc accgccgatg 838081 acagcaccag ctgtggcacc gccggcaaca aaaatcgtat tattcacagc attcccgacg 838141 gccttggcgt tttcacgctt gagaacttcc ggtttatcct ggtattttgc ataattttca 838201 gcaattttca cgcctgctcc gaatgtttcg gtcgctccgg taatcagtgt ggcggtaatg 838261 gcatttcctt tcgcgaatct caagcccgtt tttcccacat ccttcaaagt ggagcgtacg 838321 ccggcttcat taagaaatcc ttttgtgtag cttctgacgc tgtttgaaaa atccaccgtg 838381 tcctgaggaa agtattttgt aaacttttta tgtaccaaat ctgaaaatgg acggtttgtc 838441 tttttcaaca aatatttagg attcaaaagc actcttgccg ctttttgata acgtgagctg 838501 tcaacggccc tggaaatatc caagagcagt tttgagtgct gggctgtatg caagccgctt 838561 ggttgtttca caaatttcgt aagccctaat ccgtaatatt ttccctgcgt cagcataaga 838621 gcggttaagc ttgtcatcgt accgtatttg tcgtaggcat tgtagagctt tcgcaaaata 838681 tcatcttgtt ccacaaattt atcgcctgtt tttctgatga aaatctcatt gtcactcagc 838741 ttagtgacga gcgcctttcc tgagctccac gcatcgccca ctccagaaaa acagctgctg 838801 tagcggggat cgcattgcaa aatcatctgc cccagctcca catgcaggtc cttatatttg 838861 ttttccatat cagttaattc agtgactaca tcatttgcaa gctgttcgag cttatccgga 838921 tcaactgcaa tgtttcctga cacaccgttc acctcccgag tttatgtctt tcctctcttg 838981 ctttacgctc cagttcttcc attctggcaa tttcagcttt tcgttcttct attttgacag 839041 cggcagcctt cagctcttgg cttgtttcaa gcagctcctg ttcgaattga tcgtaggcgg 839101 ctttcgtttc ctcgaaatcc tggtcaaacg aatctcttgc tttgccctgc caagcatctc 839161 ccaatgcaga taaccgggat tcaagcagca ttttggagct tctgacctct tctgcggccg 839221 cactatactt gtttgccagc tcaatgactt tatatgagtc caacttttgt cccctgcctt 839281 ttctaaattc acgcacaatt ggatgtttta tataaatgat tataaataat tcggcatgta 839341 tccgaatcgt acaaaagaac cttttcataa gaattggaag ggcgtatatt cacttaaaat 839401 tcacagttgg tgagacttta agattacaaa aaaggtaaaa aaaccaaatc tctcagacat 839461 aaggcaaatg agaaatttcc cgctctatgg gaaaaaacac taaagttgat caaatgacct 839521 aagtgcgcca aacgtgttac gggacgagct atctcatggt ataaatggaa ttgtaaacgt 839581 tatcaaggag gtcgtcatat gaagaaaaaa tcattctcaa tcgtaatagc gggcggaggg 839641 agcactttca ctccagggat cgtactcatg ctcttggacc atttggagga gtttccgatc 839701 agaaagctga agctgtatga taatgataag gagagacagg atcgaattgc aggcgcctgt 839761 gacgttttta tcagagaaaa agcgccggat attgaatttg cagcgacgac tgacccggaa 839821 gaagctttta cagatgtcga ttttgttatg gcgcacatca gagtagggaa atacgcgatg 839881 cgcgcgcttg atgagcaaat tccgttaaag tacggagttg tcggccagga gacgtgcggg 839941 ccgggcggga tcgcatacgg tatgcgttcg atcggcggtg tgcttgaaat attagattac 840001 atggaaaaat actcgcctga tgcgtggatg ctcaattatt ccaatccggc ggcaattgtg 840061 gctgaagcta cgagacgcct tagaccgaat tctaaaattc tcaatatctg tgatatgccg 840121 gttgggatcg aagaccggat ggcgcaaatt cttggcttat cctcaagaaa agaaatgaag 840181 gtccgctatt acggattgaa tcatttcggc tggtggacat cgattcagga tcaagagggc 840241 aacgatttaa tgccgaagct gaaggaacat gtatcccaat acggttatat tccgaaaaca 840301 gaggctgaag ctgtggaggc aagctggaat gacacgttcg ccaaagcgcg tgacgtgcag 840361 gctgcagatc ctgacacact gccgaatacg tatttgcaat attatttgtt cccagatgat 840421 atggtgaaaa aatcaaatcc gaatcatacg cgggcgaatg aagtcatgga agggcgcgaa 840481 gcttttattt tcagccaatg tgacatgatc acacgtgaac agtcctcgga aaacagcgaa 840541 attaaaatcg atgaccacgc atcgtatatc gttgatcttg cccgggcgat tgcctacaac 840601 acaggtgaaa gaatgctgtt gattgttgaa aataacggtg caattgcgaa ctttgacccg 840661 actgcgatgg ttgaggtgcc atgcatcgtc ggctcaaatg gacctgaacc gattaccgtt 840721 ggcaccattc cgcaattcca gaaagggctc atggagcagc aggtatccgt tgagaagctg 840781 actgttgaag cgtgggcaga gaaatcgttc caaaagctgt ggcaggcgct gatcctgtca 840841 aaaacagtgc cgaacgcgcg tgtggcaaga ctcattcttg aggatttagt ggaggccaac 840901 aaagacttct ggcctgagct tgatcaaagc ccaacccgca tatcataaat gaaattcccc 840961 cattttcgaa tctgtaattg tatataatag aaagaaaatg gggggatctg atatgcagct 841021 cgaagaactg atcaatcagc actacagcaa attgaatgac aacgattttc atattttaaa 841081 atatatattg aatcataagc acacatgcta tcaccttgga atcgacgcgc tggccaaagc 841141 ttgcagtgta tcgcgttcct caattttacg gcttgcccaa aagctcggtt tcagcggtta 841201 cagtgaattt cgcgtctttt taaagtggga agatcagccg gaagaaggcg agagtatgag 841261 ttttgaaaag ctgcttgatg atattgaagc aaatttgaag tttttacgga caaaggacat 841321 gacggacatg tgccagctga ttgatgcagc tgaccgcatt ttcgtctacg gttctggaaa 841381 tgcgcaaaag atatgcgccc gcgacctgca aagaatgttt attccgcgcc atcgctatct 841441 tattttgatt gaagacacaa atgaatttaa tttgatgcgc gatgatttta aagtgaacga 841501 tctgtttatc atcatttctc tttccggaga aacaccggag ctgattcctc aggcaagaat 841561 gctttctgca aagggtattc cctttatttc cattacgaat ttaaaaaaca atgtcctcgc 841621 ccagctgact ccgcataatc tttatgcgac aagcaaacct gtgacattaa gcgatagaac 841681 ggaaattgtc gcttttgcac cgttttttct cgttggcgaa gcattgttcc gcgcatatgt 841741 tgattacaaa gaggcagaaa aaaatgacaa tgagtagcag ggggttctgg tatgatgcaa 841801 aaaattcagc gctttggaag cgcgatgttt gtgcctgttt tattattcgc gttcgccggc 841861 attatcgtcg gtatcagcac gctctttaaa aataaaaccc tcatgggacc gctcgccgat 841921 cctgacggtt tttggtatca gtgctggtat atcattgagc agggcggctg gactgttttt 841981 aaccaaatgc cgctcttatt cgccattggc atcccggttg ctttggcgaa gaaagctcag 842041 gcacgcgcct gtttggaagc gcttactgtc tacctgacat tcaactattt tgtcagcgcg 842101 atattgacgg tatggggagg agcatttggc gtcgacatga atcaagaggt cggcggaacg 842161 agcgggttaa cgatgattgc gggcataaaa acgctcgata ccaacatcat cggagccatc 842221 tttatttctt cgattgtcgt ctttttgcat aatcgctatt ttgataaaaa actgcccgat 842281 tttctcggca tctttcaagg ctcaacatat atcgtgatga tttccttctt tattatgatc 842341 ccaattgcgt tggctgtgtc ttatatttgg ccgatggttc aatcgggaat cggctcgctt 842401 caaagcttcc tggttgcttc tggggcggtg ggcgtttgga tatacacgtt tttggaacgg 842461 attttaattc cgaccggcct tcatcacttt atttacacgc cgtttattta tggcccggct 842521 gtagcggaag gcgggatcgt cacgtattgg gcacagcatc tcggcgaata ttcgcaaagc 842581 gccaaaccgc tgaaggagct ctttccgcaa ggcggattcg cgcttcacgg caactcgaaa 842641 atcttcggta ttccgggtat cgccctggct ttttatgtga cagccaaaaa ggaaaagaaa 842701 aaactcgtcg cagggctgct gattcctgtc acactgacag cgattgtcgc cggtattaca 842761 gagccgattg agtttacgtt cttattcatt tcacctttct tatttgcggt tcacgccgtg 842821 cttgccgcca caatgtcgac agttatgtat atggccggcg tcgtcggaaa tatgggaggc 842881 ggactgattg aggcggtaac cttgaactgg attccgctct ttggcagcca cggtatgaca 842941 tatgtgtatc aaattttgat cgggctctcg tttacagcaa tttatttttt cgtcttcaga 843001 tttttaatcc tcaaattcaa tatcgctaca ccaggacggg aaaaggatga acagcaggaa 843061 acaaagctat attcgaaaaa ggaatacaga gaacgaaaaa acaaggatga aacggcctcc 843121 gctgctgaaa cggctgatga caccgctttt ctgtatattg aagcgctggg cggaaaagac 843181 aacatcactg aagtcacaaa ctgcgccacc cgcctcagag tcagtgtcaa ggatgaaaca 843241 aaggttgaac ccgacagcgt attccgcgcg cttggcgcac acggcgttgt caggaacggg 843301 aaggcgtttc aggtaattat cggattaagc gtgccgcaga tgcgggagcg tgtggaaaaa 843361 atattgaatc aataaagact gccctccttt tcgggagggt tttcgtttgc cgtcaaaaag 843421 accgccatag taaagtaaag aaagagacaa tcgagtaaaa aggggtttgg aggcttttac 843481 atgcaaaagg ctttgtcgtt tttaaaacca tattcattgc tggcgggaat tgctctgatt 843541 cttatgctga cggagcttgc agttgaactg atgcagcctt tattgattgc aaaaatcatc 843601 gacgatggga tattgaagca agatctgcgg catgtatgga tatggggcac ggtcatgatc 843661 gggctgaccg tgttatcctt tgcggcgggg atgctgaatt ccttttatgc cgcccatgtc 843721 agccaaagct tttcctatga tacgagaaaa gggctttttc aaaaaatcca gtccttctcc 843781 tattccacat ttggacagtt ttcgtcctct tcttatatta caaggctgac aaacgacgtc 843841 acacaggttc aaaatatgat ttttatgagt ttgcggttta tgctgcgggc tcccttaatg 843901 attgcaggcg gcattgtgct gtcgcttgcc gttaatgtga aactcgggtt ttttctgctt 843961 gtgaccattc cgatcctgat cttgtttttg ctatgggtat taaggaaagg cggggcactg 844021 ttccgctcag tgcagaaaag gctggatcaa gtgaacacca tcatgcagga aaatttaatt 844081 gcaatcaagc tgatcaaagc gctgcttcgc ggcagccacg aagtcaaacg atttatcaaa 844141 gccaacacaa ggctgatgga aaaaacggtt tcggcctttc agcttgtgga attcacgatg 844201 cctgtactga tgctgctgat gaatctctgc atccttttga ttttgtgggc ggggtcctac 844261 agtattacga gcggaagcac tcaggttggc gatgttgttg cgataattaa ctacgcaaca 844321 cgaattacag gcgcgctttc gatgtttccg tttttgatta tgattttcac ccgggcgaag 844381 gcttcagggg atagaatcgg tgaggtgctt gaaacagaag gcgacgagcg ggaggaaggc 844441 accatatctg atcgtttgtc aggacggatt gagtttcagc atgtatcctt tcgctatcct 844501 gaaatggaca gagaagcgct caggaatgtc tcattttccg caaagccaag agaaacgatc 844561 gcgattctcg gtgcgacggg ctcgggcaag tccacgcttt ttcagctcat tccgcggctt 844621 tatcagccgg attcaggccg catttacata gatgaaaagc cggttcaaga tattccggct 844681 gaagggctgc gcaggcaaat tggatatgta ccgcaggaag tcctcttgtt ttccggcaca 844741 atcaaagaaa acatcgcttg gggcaaagaa aatgcttcac tagatgaaat aatggatgcg 844801 gcaaaacttg cgcaaattca tgaaacgatt ttaaagctcc caaatggata tgacactgtt 844861 ttggggcaaa gaggcgtcaa cctgtccggc ggccaaaagc agcggatttc cattgcgcgg 844921 gcgctgattc gaaaaccggc tatccttcta ttagatgaca gcacaagcgc gcttgatctg 844981 caaacggagg cgaagctgct tgaagcaatc agcacatacc attgcacaac tttgatcatt 845041 acacaaaaaa taaccacggc gatgaaagct gatcagattt tgctgcttga ggacggcgaa 845101 ctgattgaaa aaggcactca cagtgagctg ctttctgaat ctcagttata caagcgcatt 845161 tacgagtcac aattcggaag ggaggggagc gagtcatgct aaaagacatc cgcaagcctt 845221 tccaatatcc caaactgcca attgacaaaa aagaaggcgc gaaaaagcgg gcgaaagcaa 845281 aggatacaaa gggcacactg agacgaatct ggtcttactt ggctgaaaga aaaggactgc 845341 tcatacttgt catgctaatg gttgtcatca gcgccatatt cggactcctt ggtccctttg 845401 tgatcggaaa ggccatcgac cattttatcg tcgggaaaac ggtcagcggc ttgattcctg 845461 ttttgcttct tctgctcgct atctatatca ttcagtccct gtcgctttgg tttcaaaact 845521 attggatgat tacgatctcg cagggcacgg ttttcagaat gagaagcgaa ttgttcaccc 845581 atctgcatga gctgccgatt ccattttttg ataaacagcg gcacggcgag ctgatgagcc 845641 gggtgacgaa tgacatcgaa aatgtcagtt ctaccttaaa cacgtcagtc attcaaattt 845701 tgtcaagtgt gatcaccttt gtcgggacga ttgcggtgat gctgtacatg agcccgctcc 845761 ttactttgat tacgctgacc attattccgg tgatggcagc gagcctgaaa tggatcacca 845821 accgaacggg aaagctgttt aaagaacagc agaaaaacct tggtgatctg aatgggtata 845881 ttgaggaatc tgtttcaggc gcaaaggtca tcaaagcata ttcacgtgag aagcagatta 845941 ctgctgaatt cctcgaaaaa aacgctgcac tcaagacgtc gggcttttgg gcgcagacga 846001 tttccgggtt tattccgaag gtcatgaact ctttgaataa cttaagcttt acaatgattg 846061 cggcaatcgg cggtttgttt gcgctgaaag gctggatctc gatcggctcc atcgttgtct 846121 ttgccgagta ttcaagacaa tttacacgcc ctttaaacga tctggccaac cagtttaata 846181 cgatgctgtc cgcaatcgcc ggcgctgaac gggtgtttga cgtgcttgat gaaaaagaag 846241 agcgcgagga tgaaaagaac gccgtgcatc agcccatcca aacaggcagc attgaattcc 846301 gggatgtgtc cttcggttac gataaagggc agcagacact gaagcattta cagtttaccg 846361 tgcctgcggg gcagtccatc gcgtttgtag gaccgacggg ggcggggaag acaaccgtca 846421 ctaaccttct cgcccgtttt tacgagccta acgatggaaa aattttaatc gatggtacag 846481 atattaaaac ccttactaga gcaagcctaa gaaaaaacat ggggtttgtt cttcaggatt 846541 ctttcttatt tcagggaacg atcagagaaa acattcgcta cggcaggctt gatgcttctg 846601 atcaggaagt cgaagccgct gcaaaaacag cgaatgccca tagttttatt gaaaggctgc 846661 caaaagggta tgacaccgta ctgacgcaaa acggttcggg catcagtcaa gggcagaagc 846721 agttgatttc tatagcgagg gcggtgcttg ccgatccggt tcttctcatt ttggatgaag 846781 cgacaagcaa cattgatacc gttacagaag tcaacattca agaagcgctc gcccgtttaa 846841 tggaaggaag aacaagcgtc atcattgccc acaggctgaa caccattcaa agagcggacc 846901 agattgtggt gctaaaaaac ggtgaaatga ttgaaaaagg cagccatgac gagctgattc 846961 ggcaaaaagg attttacagt gacttatatg aaagccaatt tgagaaatag acctttgtcc 847021 tgcacagagg tctttttttg ttacagtttt atagtacttt tatttcattt tcgtaaaatg 847081 taacaaaatt acttgacgta aacaagttat gtatatatac tagcttacat taagtaagtg 847141 ataacattta tcaaggagga taaaatgaat aaatcatttg aaattggcac attactttta 847201 agagttatta caggtattat cttttttgtt cacggtttat caaagtttca gggaatggag 847261 ggcaccatcc aatttttcgg cagcataggc cttccaagct ttatggcgta tgtcatcgca 847321 gcgattgaac tgattggcgg agtgcttgtc ttcttcggat tggctacacg tattgtcggt 847381 gtactgttcg ctcttacact gatcggcgcc atcatcactg ttaagctgaa agcgccattc 847441 atgggcaatg cagaatttga ttaccttctg cttttgacat ccattcacct ggcgcttact 847501 ggaagtcgat tcctggcgct ggacccattt gtgtttaaag gaaaaaagaa cggaaacgtt 847561 tcagcataag aaaagaggca tgcagcatga ccagcattca tgaggataca cacattggct 847621 atgccaaact cacaattcgc agtctggagc gttcgcttca gttctactgt aacgtcatcg 847681 gttttcaagt cttaaaaaag acggaccgcc aagcggaatt aacggctgac gggaaacgcg 847741 tactgcttat tcttgaagaa aatccgagcg ctgtcgtctt gcctgaacgg tctgtgacag 847801 gcctttatca ctttgcgatt cttcttccgg acaggaaaga acttgggatc gcgctcgccc 847861 gcctgattga acacggcatt gctatcggac atggagacca tgctgtcagc gaagcgctct 847921 acctgtctga tcctgacgga aacggcattg aaatgtacgc tgaccgcccc cgcagcacgt 847981 ggcagcgtga tcgggaagga aactacgtca tgacgacaac cgctgttgac attgagggcc 848041 ttctggaaga ggcaggagat gagcggaaaa catcgcttcc gaacgataca atcatcggac 848101 acattcatct gcatgtcagt gatttgaaag aagcaaaggc gttttataca gatgtactgg 848161 gctttgacat tgtcggaaac tatgcgggca tgtccgccct cttcgtttca gccggggggt 848221 accaccatca tatcggctta aacatttggg cgggaagaaa tgcgccgcct aaaccgacaa 848281 atgccagcgg actagattat tatactgttg tcctgcccca ccaagaggag ctggatttgg 848341 tggcaaaccg agtcaaacat gccgggtatt cgattgaaga gacggaaaac agctttcgtg 848401 tgaaagaccc tgtttccggc gcctatatta catttgtgat ttaactgcaa tccccttgcc 848461 gaaataacgg cagggggatt ttttattttt gtccgccttg ttatgatgag agaaccaact 848521 tgttaggagg cgtttacatg gaactcaacc accttgtgac gggcaaaata gcattaaatc 848581 aatatgtgca tcgcttagag caaaaggatg tttcatttta cgtccactac tggggagcga 848641 tgacgaacca ctataacaca ctgcttcata agcattcctt ttatgaaatt tgttacgtgg 848701 taagaggtga aggatattac cttgaaggcg atcgtacata tccgcttcgt gaacagacga 848761 tttttttgtc aaagccggag catttgcacc aaatcaaaag tgaaacaggg ctgttccttt 848821 tttacgtcgc tttcgagctg agcgaggatc agtcaagcgc cgaatggatc aaagtgatgg 848881 aagaagtgaa acaaagcccc tttatcacaa tgcaattgaa agatggcgaa ccgccgggcc 848941 tgctttggaa aacgttaatg ctgcaagcag cgcaacctgt caatgctttt gacaaagaga 849001 tcctatctca tttgtcgcat gcattgatcc tgtcattaat ccaaaccttt ctcccgtacg 849061 cccaacgccc gaaacaaaag cagcccattc acacatcttc tgctttgctg acagaggtga 849121 aactgcacat aaaagacaat ctgtcacagc cgttaaagct gacggatgtc gctagccact 849181 ttcatatctc agggaggcat ttatcacgtt tatttgcagc agaactgggc gtcagctact 849241 cagaatttgt ccaaaatgaa aaaataaaca aagctgccga actgctgaaa tcaacgaatt 849301 tgtcgattaa agaaatagcg gaagaaatcg gtttctcagt acattatttc actcgcgtct 849361 tttccgctaa aatcggcagc tctccagggc ttttccgctc cctttataaa gactcaaaaa 849421 tgaccgcatt tcaaatcaat aaaccttttc aaaaaatcga acaggccaag ccgcacgaat 849481 aagatgtcct gaaatgacaa aacaatgtct tcatatgata aagacgcgag aaatctcgtt 849541 gtcttataat ctttttagaa agcggttaca acaaggggta ttgctgaagg agggatgcat 849601 tggcttatgc ttggtgtcgg gtgctctgcc attcttgaaa gaaggggaag aaagccgtga 849661 gtacaaaaaa gaaagaggct gtaataggaa aagaaagctt agctcataaa gggcttttac 849721 gaacgattac attggtatct acattcggcg gcctgttgtt cggttatgat acgggtgtca 849781 ttaatggggc acttcctttt atggcaactg caggtcagct gaatcttaca cctgttacag 849841 aaggactggt tgcgagttcc ctgcttctcg gggcagcctt cggggcgatg tttggaggac 849901 gtctgtccga tcggcacggc cgccgaaaaa cgatccttta tttagcctta ctcttcatcg 849961 cagccacact tggctgtacc ttttcaccaa acgcgtccgt gatgattgcc tttcgttttc 850021 tgcttggact ggcggttggc tgcgcttctg taacggttcc aaccttttta gcggaaattt 850081 cgccggcaga acgcagggga cgaatcgtga cacaaaatga actgatgatc gtaattggcc 850141 agcttctggc atacaccttt aacgccatta ttggcagcac aatgggggag agcgcaaatg 850201 tatggcggta tatgctggtc atcgcgacac ttccggctgt tgtgttatgg ttcggaatgc 850261 tcatcgtgcc tgaaagcccg cgctggctgg cagctaaagg cagaatgggt gacgccctgc 850321 gggtgcttcg gcaaatccgt gaagacagtc aggcacagca ggaaataaaa gaaatcaaac 850381 atgcgattga gggcacagca aaaaaggccg gctttcatga ttttcaagag ccgtggataa 850441 ggcgcattct attcattggg attggaatcg ccatcgtaca gcaaattacc ggtgtcaatt 850501 cgattatgta ctatgggaca gaaattctga gagaagccgg ttttcaaaca gaagctgcat 850561 taatcggcaa tattgcaaac ggtgttattt cagttattgc ggtcattttt gggatatggc 850621 ttctcggcaa agtccgtcgc cggcccatgc tgatcatcgg acagattggc acgatgacag 850681 cccttctgct gatcgggatt ttatccattg tccttgaagg aacacccgcc ctgccgtatg 850741 ttgtgctgag tttgaccatt ttgtttcttg cgtttcagca gactgccatt tctacggtga 850801 cgtggctgat gctctcggaa atctttccta tgcatgtgcg ggggcttggc atggggatca 850861 gcaccttctg cttgtggaca gctaactttc tcattggatt cacctttccc attttgctca 850921 atcatattgg gatgtcggcg acatttttta tctttgtcgc tatgaatatc ctagcgattc 850981 tatttgtgaa aaaatatgtg cctgagacaa aagggcggtc acttgaacag cttgagcatt 851041 cctttcgcca gtatggccgc cgcgctgatc aggaaatcca aaatcaaaca actcacttat 851101 cgtaacctga gataccagga ggaatctatc aatgaaacta tcttatgtaa cagacagcct 851161 agggcatttg ccttttgaag acatgctcaa ttttgccgca aagcttggga tcgatacact 851221 tgaaatgaca accgggggct ggtcgccggc acctcacttg aatcttgatg aattgctgca 851281 aagcagcgaa aaaagaaaag aattttcaca agcgctggaa aagcggaaca tgacactttg 851341 cgcattaaac tgctcgggga accctttaga tccgggtgaa ttgggcaaat cgcacagaga 851401 cataactgac aaaacgatgg agctggctgg attattaggc gtcaaaaaag tgatcatgat 851461 gagcggtttg ccagccggcg gcccggacga caaagtgccg aactggatca catacacagt 851521 aagctggcct cccgttttaa aagatatcct caactatcaa tgggaagacg ttgcgatccc 851581 atattggaag aagcttgtca aaaaagcgga ggcctgcggc gtggggaaaa tagcgcttga 851641 gaacttcagc tctcaattag tctataatcc tgagactctc tttcggctca gaaatgcagt 851701 cggcccgatg gtcggtttga atcttgaccc gagccatttg ttatggatgg gcgcagaccc 851761 gatcatcgca gcaagggagc tcggctcagc cattcaccat gtccatggga aagatgtcag 851821 aattgaaaga tatttatcgg cggtcaacgg acttttagaa acaaaagaag tgacagatcc 851881 tgcaaaccgg gcgtggaatt acgtagctgt cggctgtgga caggatttac agtggtggaa 851941 ggaatttttt tcagttgtaa aaatgatggg atatgaaggt gaggtttctt tagaaatgga 852001 ggatctgacg atgtcacctg aagcgggcat ccgtacttct gtagaagctt taaaacaaac 852061 catcagccaa taggaggttt tcatgatgct aaatggagaa agaatcatct ctaagccgct 852121 tcgctgggca atggtaggcg gcgggcggct cagccaggtt ggatataaac atcgtattgg 852181 agcgctgaga gacaatactg cttttcaatt aactgctggc gcttttgata tcgatgccga 852241 aagaggaaaa gatttcgggg tgaaccttgg agtggatgcg gaacgctgtt atcccaacta 852301 tcaaaccatg tttgccgagg aagcgaaaag acaggatggc atagaggtag tatcgattgc 852361 cactccgaac ggcactcatt atgagatttg taaggcggcg cttgaagcag gagtgcatgt 852421 catctgtgaa aaaccgctgt tcttcacttc agcagagggg caggaaatca aagcgctcgc 852481 agagaaaaaa gggaaaattg tcggcgtgac gtacggtttt tcaggcaatc aaatgcttct 852541 tcaaatgcgt gcgatgattg aacaaggaat gatcggcgat attcgcgtgg ttgacttgca 852601 gtacacacac ggtttttgtg caacagatga aggtgaaaag ataagcgctg cacagaaatg 852661 gcgtgtcgac cctgcgatcg ccgggccaag ctttgtgctg ggcgatttat ctacccacac 852721 gtattatatg tcacagctta ttatgccaaa gatgaaaatt aaggagctgc tgtgtgaccg 852781 acagagcttc gtcggcagcc gcgcaccgct agaggataat gcccatgtgc tgatgcatta 852841 tgaaaatgga gcggtcggaa cgatgtggac atcgtcaatc aatgccggat gtatggatgg 852901 ccatagaatc cggattgtcg gctcaaaggc aagcattgag tggtgggaca gcaagccaaa 852961 tgaactgacg tatgaagtgc agggagagcc gggccagaca ctcgttcgcg gcatgccgta 853021 tttagatgat gtttgcaacg ccgatgaacg actgggcgcc ttacacagcg aagggctgtc 853081 cgaagcatgg gccaatattt atcttaaatt tgccattgcg atagacgcca aaaaccgtga 853141 agatgaagaa atcttgaaca acttggttta tcctgacatt gatgcaggga tcgagggcat 853201 tcgctggatt gagaactgcg tgcgctcggc aaaccaaggg tcagtttggg ttgaatttaa 853261 ataaatgagg gaatgcgccg catatgacat aaagttcata tgcggttttt attttccaga 853321 aactcctgtc aaaaatgccc tgaggcaggt atgataagaa gggaattggg tatcgggagt 853381 gatgagcgtg aaagctcttt tttttacgag aatgttcacc ttgatggtga gctgtttaat 853441 gtatctgtcc attgtgaaag aggataactg gtttggatat gtatttatag cagcaggtgc 853501 tgccatgtat gcagccaatc atgttttgct gacaaaagag acaaatgcca tctggttctg 853561 cctgattgat attgcaatcg gcttttcgtt cggatttatc tttcccggca caggtttgtt 853621 cattattatg ctttgtccgg ttgcggtcgc cttttttctg cgggggtttc ctaaaagaac 853681 agcatggtct gtcttatgtc tttcctctat tttatttttg accgtcctca tccgtacata 853741 tgcgatgttc ggcaatgaat ttgtcattga tcatttgact agcatgacat tcgttgtctt 853801 ctgcggtgtc gtgggcaaat taatccgcaa gctgttggat gcgcaggata cggcaaaaca 853861 gcagtttcag gaactgacgg agtcccatct ggcgctgtct gctgcacatc aggagctcca 853921 tttatatgcg aagcaggttg aagagctgac tgccatttac gagcggaaca gaatggcgcg 853981 tgaaatccat gatacagtgg ggcataaaat gacggccctt ctcgtccagc tgcagctttt 854041 gcgtgaatgg caaaaaagag acagccaaaa agcggatgag acagtaggtg tctgtgaaac 854101 acttgcccgt gaagcgcttg atgatgtccg cttatcagta cgcactctgc aaactgaaaa 854161 cgatccttcg ctaatcgaat cgctgaaaca gctgacagag gacttttgca aaaatgcagg 854221 agtcacaaca gaatttgcgg tcagcggtga tcctgcaatc atcccgctgt ctctccatcc 854281 gaccctgatc agaacggtgc aggaagcact gaccaatgcc aaacggcacg gcggcgccgc 854341 agcctgttcg atacagcttg cctgcacaac ggacagcatc agccttgtca ttaaggatga 854401 cggcaaaggc aatcctgagg cagcacttgg ttttggtctc ttgaatatga aaaagcgggc 854461 agcggagcat ggcggaatga tccgctttga aagcgaacgg gatcaaggat ttactgtaaa 854521 tgcagaattt tcacttgcca ataaaaaatg gagcttcggg cccgtgcagc aaaaggagag 854581 tttatcatga ttaagatcat cattaccgac gatcaggata tcgtcagaga agggctggca 854641 tccctgctcc agctccgaga agagctcgat gtgatcgcaa cggcgcgaaa cggacaggaa 854701 gccttcgaaa aggcgaaaga gctggagccg gatatcgtgt taatggacat ccgcatgccg 854761 gtttccaacg gggtggaggg aacaaaatta atcacaagct cgctgccaag cgtaaaggtt 854821 ttgatgctga caacctttaa ggattcagcg ctgattgctg aagcgcttga agagggagca 854881 agcgggtatc tgctgaagga tatgtctgca gatacgattg taaaagcagt gatgactgtt 854941 cattctggcg gaatggtgct tccgccggaa ttgactgccc aaatgctgaa tgaatggaag 855001 cgtgaaaaac agctgaaagg aataaatgag atagaaaaac ctaacgagct gctcgacctg 855061 accgagcgcg aaatcgaagt tctggctgag ctgggatacg ggctgaataa caaagaaatt 855121 gccgaaaagc tttacattac agaaggcaca gtcaaaaacc acgtttcaaa tattatcagc 855181 aagctggctg tcagggacag aacccaagcc gccatttact cggtcagata tggtgtatct 855241 gtcttttgac atatgacgtt ttgcatatac gcttctctga aaaggccttt tacaggcctt 855301 tttttcatgc cctatgttct atctgccgct acatgccgca cgcctttctt tcttctacaa 855361 tggcaatgga tcaaaaaaag gagtgagacg acgtgctgca agcagaaaac atcaaaaagg 855421 catacggaaa aaaaacaatc gtgaaaggca tttctttttc cctcaaaaag ggggagtcgt 855481 tcggtctgct cgggcctaac ggtgcgggga aatccacaac catctcgatg atttccggcc 855541 ttgtgccgca tgacagcggg aacatcacgg tgggcggcta tgttatcgga aaagaaacgg 855601 ccaaagcgaa acaaaaaatc ggcattgttc cgcaggaaat tgcattatat ccgacgctga 855661 cggctcatga gaatcttatg ttttggggga aaatgtacgg acttacgcac ggtgaggcca 855721 aaaaaagagc ggctgaggtc cttgaatatg tcggtctgac tgagcgggct aaagataaga 855781 ttgaaacatt ttccgggggg atgaaacgaa gaatcaacat cggtgcggct ttaatgcata 855841 agcccgagct gctgattatg gatgaaccga ctgtcggtat tgaccctcaa tcgagaaatc 855901 acattttaga aacggtcaaa cagctcaacg aaacgggcat gacggtgatc tatacgagtc 855961 attacatgga agaagttgag tttttatgcg accggatcgg gataattgat cagggggaaa 856021 tgattgcgat tggcacaaaa actgatttgt gcagccgcct tgggggcgat accatcattc 856081 agctcacggt cagcgggatc aatgaagcgt ttcttgtggc gatccgatct ctggcccatg 856141 tgaatgatgt aacagtacat gaattagagc tcaaaattga catttctgcg gctcatcatg 856201 agaaagtcgt cacaagcctg cttgctgaag ccactgctca tcatataaac ctgctgtctc 856261 ttcaggtgca ggaaccgaat ctggagcgcc tgtttctgaa tctgaccggc cgcacgttgc 856321 gggattgagg agggacggca atgaaaaaaa gcatatggat cgcatggaaa gatgtgaaaa 856381 tcagaatcac ggacagaaaa gggtttatga tgcttatcct aatgccgctc atcctaacct 856441 gtattttagg cgcagcgctc ggatcagttg ttgacggagg cagccggatt gatgatatca 856501 aagtcggcta cattcaatca gaccagtcag atacagcaaa catgtttaca aaagatgttc 856561 tcaaaaaaat gaagtcgata aaggtcacaa aagtcggcag caaagacaag atgaaaaaac 856621 tgattgatga aaagaaaatc gatgtaggca tcgttatccc gaaccattgg gaagccggca 856681 aaacctcagc tgttgttaat gccgctcctg atcaaacatt gaaaagttcc atcattgaaa 856741 cagctgcaag ctcatttata gagcaatata aagcggtaaa ggaagccgcg tcaggctcaa 856801 tggactacat cagtaaaacg gaagctgtaa agcaaggaaa acttgaccct gcacagtttg 856861 cagaaaagct ggcaaagacg ctagaaaaag aaacaggtga caagcttact attgcggaaa 856921 aatctgtcgg cagcaaagcc gttaccagtt ttcaatacta ttcggcggca atgctttgca 856981 tgtttatgct gtttcatatc acagtcgggg cgaaatcatt tttacaggaa aaggatacgg 857041 agacgcttgc cagaatgctg atgacgcctg cgcaaaaatc cgtcattctc ttcggaaaat 857101 ggcttgggac gtatctgttt gccatcatac aatttttcat atttctgatc gtcacaatca 857161 acgtatttgg tgtggactgg ggcggtaatc tgctgttagt gagtgtactc gggctttctt 857221 acgccgcagc tgtatctggt atttcaatgc tgcttgcgtc gtgcatcagc gatatgaaaa 857281 ctgcagatgc gataggcggc ttcggcattc aattgcttgc ggttctcggc gggtccatgc 857341 tgccgctgta ccaatttccg gacgtcttgc agtctgtatc caaagcggtg ccaaatcgct 857401 gggcgcttga cggctttctt tctttaatgg aagggggagg ctgggctgac cttcaaaagc 857461 ctgtgcttct ttttgcggcg atcggctttt gttcacttgt aattggtatc agacggcttc 857521 atacaagata aggaggtaca aaaggtgaaa aaaattctag ccatttgcgg cattgagctt 857581 tctctcattt ttaagaagcc acagaactat ttgatcatgt ttgctgcccc gcttttgctt 857641 acctttgtat ttgggagtat gctcagcggc aatgatgata aggtgcggct tgcaatcgtt 857701 gatcaggacg atacgattct ctcacagcat tatattcggc agctgaaggc acacgatgat 857761 atgtatgtat tcgaaaacat gtctgaaagc aaagcgtcag aaaagctgaa acaaaagaaa 857821 attgccggga tcatcgtcat ttcccgctcg ttccagacac agctggaaaa aggcaaacat 857881 cctgagctga ttttccgtca cggccctgag ctgtcggaag cgccgatggt caaacaatat 857941 gcagaaagcg cattggcaac gctcaatatt caggtgaccg cggcaaaaac ggcatctcag 858001 acagcgggag agaactggaa ggcggcgtat aaaacggttt tcgccaaaaa acatgaagat 858061 atagttccgg ctgtaacacg acagacgctc agtgataaaa aagagggtgc ggaagcaagt 858121 gacacagcct ccagagcagc agggttttcc atcctgtttg tcatgctgac catgatggga 858181 gcggctggaa ccattttaga agcaagaaaa aacggcgtat ggtccagatt gcttacagcc 858241 tctgtcagcc gagccgaaat cggtgctggg tatgtgctgt ccttctttgt cattggctgg 858301 attcaatttg gaatattgct tctttccacc cattggctgt ttggcatcaa ctgggggaat 858361 ccggctgcag ttattgtatt agtgtcactt tttctattga ccgttgtcgg cattggattg 858421 atgattgcgg ccaacgtcag aacgccagaa cagcagcttg cgttcggcaa cttgtttgtc 858481 atcgcaacat gtatggtgag cgggatgtat tggccgatcg acattgaacc gaaatttatg 858541 caatccatcg ctgaatttct tccgcaaaag tgggcgatga gcgggttgac agagattatc 858601 gctaacggtg cccgcgtcac agatattctc ggaatctgcg gcattttgct tgcatttgct 858661 gcgatcactt tcgcagcggg gctgaaagcg ctccgagcct aaaaaacatc tgccgtttag 858721 gcagatgttt ttttgcatgt gggtacattc gtatgggtgc agcctgaact gcggttaatc 858781 cttatctatc atagctaaaa ttgattccag ccaagaaacg taatttttct cccgctccag 858841 cgctttcgtt agcacaagat agtggccgaa gtccggtgaa gaaaatgaca tcggctctgc 858901 tgaagccata agcttttcat agcttccctg taagtcagaa agcttggcct ggcgtttttg 858961 cagctggtct ttgaacaaat cagaagcctc ctggcgcgat agacaagaaa tgaaataagc 859021 cttcagcata aattcatcct tcaccgtctc gggtatcggc tggtggcgga tcagccagtc 859081 atgcagctcc tgctttccgc tgtctgtcag ggtgtacatc tttttctcca gctttgtgcc 859141 ctgaatcgtt gtccggaacg tgataaatcc ttcatccgtc agctttttga gctcagggta 859201 aatctggctg tgcttggcgc tccaaaactg gccgagctcc tctttaaaat aactcgtaat 859261 atcgtatcca ctcaattcgc cttttcgcaa aagccctaat atggcgtatt ttaatactct 859321 catgctatcc tccgtgtctg gctgtttcgc aaaacagatg agccggtgct caactgtgat 859381 tctaactgcc tattcccctt attatagaaa agggaggaag ggaacacaac cgggctcttt 859441 ggaaatgaag ataaaaggtt tgtcagaagg tatccgattt atctccgtca atataaaaga 859501 gatttaaatt taattttcag aaaaaatagt aacgatattg attttttata tataatagga 859561 aattggtggt atgaaaattt tttgggggaa taaacgtgaa aaaagtactt atggcattca 859621 ttatttgttt atcgctgatt ctatctgttt tagccgctcc gccgtctggc gcaaaagctg 859681 agtcagtaca taatcctgtc gttcttgttc atggaataag tggtgcatca tacaactttt 859741 tcgctattaa aaactactta atttctcaag gctggcaaag caacaaactg tacgcaattg 859801 atttttatga taaaacagga aacaacctaa ataacggccc gcagcttgct tcatatgttg 859861 accgtgtttt aaaagagact ggggcaaaaa aagtagatat tgtggctcat agtatgggag 859921 gcgccaatac gctgtactat attaaatatt taggcggggg caataagatt caaaatgtcg 859981 taacgcttgg aggggctaat ggtttagtgt catcaaccgc gctgccgggc acagacccta 860041 atcaaaagat cctctataca tctatttaca gtctcaatga tcaaattgtc atcaatagct 860101 tgtctcggtt acaaggagcg cgaaacatcc agctttatgg catcggtcat attggcttgc 860161 tttctaatag ccaagtgaac ggctatatca aagaagggct gaatggcgga ggcctcaata 860221 caaattaata tcttcaaaaa acaacctgct gtctccgtta cagtgggttt tttcgtctga 860281 gaaagccata gggtcttatg accttagtct atcatgcata cgtcaattta tgacatcagg 860341 cactttttca aatagagcgg acatgttaag gtacaaccat cgatttctat caatttgaaa 860401 taaaaggagc gctgttatgc aaattaaaga aatttttatg atccgctgca tttcgtgctt 860461 aagtgtcgtc ttgctccata tcatttcaat ggtcctgatg cttcaggcag aagctcttgc 860521 agatatttct cacactgttg attctttccg cacactcctg atgttcagca cgcccgcttt 860581 tattttcatc tctgaatttt tactggcccg ttcttatcct gatggggtgc ctgacggttt 860641 tttaaagaag cggggaaaag tgatttttgt tcctttttta tttatcgcag ccatcgatgc 860701 gctgctgatg accagtgcga tggggggaga ggtaaccttt ctcgcgtttg tgcaaaaata 860761 tctggcgaac gtattcttag gaaactttat cggatacttc attctcgtca tctttcaatt 860821 ttacatgctg catatgatgt ttcatgagta tttgaaaaaa gcatcgccga aatgggtgct 860881 gtctatctca tttgtggtga cagccgctta tttaggctat ttctccgcag ccagcccggc 860941 tcctgcttct gaagagggag gggcatttcc gttcttctgg gttccgttcg caggctggct 861001 tttctacttt tgtctagcct actattgcgg aaaagaatac aagcgttttt tagcgctgct 861061 gaaccaatac cgctgggtgg tgtacggcgc cgcaattgct tctggggcgc tggttgtcac 861121 tgtttcttat gtcggtgaaa tcggcatgat cagctcgaag cggcctgata tcatgctgta 861181 ttcaacaagc atgattttcc tgtgttttca tttgttttcc aaaatgaagc atgtgccgaa 861241 aatcatgatg tttatcagca actattcctt ttcgatttat ctgcttcatg cctattttat 861301 gattataggc tacgtgttgc ttttgaatat gcccgaaatt cctgccgtac cggctgttct 861361 cctgttgttt gccgtgtgca cagccggccc gattatgacc tcatgggcgc tgaataagtt 861421 caaatacggg tatttatttg tggggaaaat ttatcagcca aaacagaaga aggtaacagt 861481 cgaagtgcgt gatcacgcag ggtgaaaaac aagcggcagg agggctcctg ccgcgtttct 861541 ttacttctca tccgcttgca gaactgtttt taaatatagt tttgcagact cagcaagtcc 861601 agatacatca gccttttctt catcgaaata cagggcgttt tgaatgatgc cgtcattcat 861661 attgaggaaa aacttggcga tagtcgcaag aggctgaacc ggctgaaact ctccctgatc 861721 gatccctttt tgcaatagcc ttgaaaacct ttccacaaaa agatcatacc ttttctccaa 861781 atactgccgc cgttcttcat tgcgccaagc tgtcactaaa tattcaaatt gcaccggcgc 861841 cagcgtatct gctacatctc gcaggccctc agtcagttca tccaaatagc tggaaatgga 861901 ggcccaaaca ctttggtgtt cagctgattt atcaagcttt cggagtcctt catccagccc 861961 tgtttcaata atgcggcgaa acatctcctc agtgcttgaa aaataaagat agacaccgcc 862021 ccggctgaaa cctgactctt ctacaacatc cttcatcgtc gttaattcga atccttttcg 862081 tttaaaaacc gttttggcag cctctaaaat ctctgcctgc cgtttatcct tgtgctcctt 862141 tgttactttt ggtgacaaga tatcgcctgc tttctgcaat tttcttacct ataagtgtaa 862201 tcaacccaat catgatcagc aagcagccac agacaagaaa agcaagtgat acaccgatcc 862261 attccgccag cacgcccccg cccgccatgc cgaggataga ggcgagggtt gtcgcactct 862321 gaatagcgcc gaacacccta ccgctgtaat cgacaggcac tgttgtttgc acgagaatct 862381 gaaatggaat atggacgagg ccgaaagccg cccccatgat gaaaaaagca aatataaaga 862441 gagtgatgcc ggcaattccc ataccgctta ggaatggcgc acctccagtt gctagtccaa 862501 gaagaagggt tccagctgag aaataaagca aataagaagt gattcgccgt ctgccggtaa 862561 tggccgctgt aaggagcatc ccggctccgc ttacggccat gcaccagcct gccagctcgg 862621 gcggagctcc tgaaaaggag cggataagaa taatcgcttg ggaatcacca atctgcaaaa 862681 caaagagaac gacacaagct gttagtaagc ctgttaatag aagcggcatc cgtttcaaaa 862741 actgaaggcc ttccttgata gaagtaagtg ctgctgtttt ttcttgaggt gtattggctt 862801 tttgtaaaaa agcatctctg ggaaggaaaa acaaaatgac agcggaaaga aagaaggcgc 862861 cggcgtttat ataaaaaaca gagtgtatcg agaaagcagc gatcagcgtg ccgccaaggg 862921 cagggccgaa gatttttgag ctgttatcaa tgatgctgct gacggaaacg gcctgctgaa 862981 tgtgtgcttc cggagccaat tccttaagct ttccgttttt agcaggtaaa aaaagtgaag 863041 aaaaacagct ctgaacggat agcaatacgt aaagctgcca aagctcactg acataaacgc 863101 agctgataac agtgagggca cggccgattt cagatagaaa catgatcgtt tttctgtcaa 863161 aacggtcggc aagcagaccc gatacaggtc cgagtacaat gacaggcaaa gcaaacgaca 863221 tcattaaaag cgacatatct aatggagaag catgaagctg aaaagcggct aatgttagca 863281 cggccaaaat gtgaagccag tctccaagtg aagaaatggt ttgcgaggct aacagtgtca 863341 tcagtccttt ttgattgcga aacaacggtt tttccatgat tcatcctcct gattattaaa 863401 atgacactag tgtcgttttt aattgtatgg gaaaaagaca caatatacaa tctttttctt 863461 gtaaaataaa ggagaagatt gaatagaagg gagaacattc atgacatcag tcaatctaag 863521 ctacccaata ggagaataca agccgaggga atccatatcg aaggagcaaa aagataaatg 863581 gattcaagta cttgaagaag tgccggcaaa attgaagcaa gctgtagagg tcatgacgga 863641 cagccagctt gacacaccgt accgggacgg tggatggacc gttcggcaag ttgttcatca 863701 tctggctgac agtcatatga acagctatat tcgttttaaa ttgagcttga cggaagagac 863761 accggctatc cgtccgtatg atgaaaaagc atggtcggag ctaaaagact cgaaaacggc 863821 agatccgagc ggctcactcg cgcttttgca ggagcttcac ggaagatgga cggctctgct 863881 ccgcaccctg acggatcagc aatttaagcg cggattttat caccctgata caaaggagat 863941 cattaccctg gagaacgcgc tcggcctgta tgtctggcac tcacatcacc atatcgctca 864001 tattacggag ctttccagac ggatggggtg gtcttaacgc ttttgccggc ggaaagccgg 864061 aatactgata gcagcaatca ccagaagtga gaccacagca gccgctgcat ataaatgatc 864121 atagccgctg gcgacactcg catgaatggc gtcgcttatc gcggttttga cttcaggaac 864181 gggaatgcgt tcgatttgtt cttgtaaaga agaaacttca gaactgtcga tctccggaat 864241 catctgcatc gccttttctg aatatccgct gtccgataag cggctgttga tctcatcacc 864301 tatttggtca aacccggctg tgataaaacc tgcataaaga gtaggcgcca aggtcagtcc 864361 aatttgcctt actaatgaaa gcgtgccaag agctgtaccc ttatttgttt ttgccgcttc 864421 tgatacaagg acgttcagcg gagcgcctaa cagaaagcca aaaccgatcc cagctgccac 864481 acttgcgatc acaaactccc atttttccgt gacccagagc ggaaataaag caaaccccgc 864541 acatgagatg attcccgaaa gaataacggt ttttacagga ccttttttgt cggtaagtgc 864601 tccgccaagc caagcgccga ttccggaagc caacgcaagc ggtgtcatcc aatagcctgc 864661 ttttgcggca gggacaccca aatactgttc gacatatgac gggataaaaa tgactgccgc 864721 caagagcccc ccggataaca aaccgatgat aagcgtgcgc tgaaacatat ggtttcgcag 864781 cagagaatac gccaaaatgg gatcgcctcc tcgcatttca actctctttt catacgagat 864841 aagcgctgca aaacagagta tgccaaaaat aatacatcca taaacctccg gattccccaa 864901 gctgtgtaag agatttgccc cgtcaagatt ggtcatgccg tacatcacag ctaaaatcga 864961 cagggacaaa aggaagattc cggccgcatc gaggcgctta gcctcaggtg cttttgtttc 865021 cgcgataaaa catgcgccga aaacaaccaa tagcacggca atcggcaaat taatcaaaaa 865081 tagccaatgc caagacccgg tccaatcaag cagaaagctt ccgatatttg gcccgagcac 865141 agcggccatc ccgttcattg cgccaagcag cccaagcgcc ttcccctgtt tttcctttgg 865201 aagggtcgcg agaatgtgag agctgccgat gatgaaaatc ccgccgcctc caagcgcctg 865261 aatcagccgc gatatcagaa agagcgggaa gctttggctc aaagcaacaa gcaaagaacc 865321 aagtccgaac aggcaaacct caatgagaaa gagttttttt ctgccgtagc ggtcggaaag 865381 ttttccgacg attggcacac tgacgctaag accgagcgta taaagggtaa tgccccatga 865441 tccccaggaa ggggaaacgg aaaacgactc gtttatcgtt gttaaagcag ccgaaataat 865501 tccgttatct aaagcagcca taaacacgcc aatcgtaaac aggctgattg cccacttttg 865561 gcttttctgc tctgttaatg cttcagacat tttcgtcaac tccttttagt tcacttgaaa 865621 tatattattc attttaaatg aactaaatgt caaataaaaa aagcctgctc ccgcagtttg 865681 cggatgacag acttactgat ttattctttt ttcgcattct ctaatgctct tgaaaggata 865741 gacagccctt cgtaaacagc ctgcttttct tcaggggaca gcagctctaa tgaacgcttc 865801 aatttcaggt ggcccttttc atacaaaccc cggaaaatct ttttcgcatt ctctgtcaac 865861 tgaacaacta cagagcggcg gtcctcttca gaatgtgagc gtttgacaaa tcctgatttt 865921 tcaagccggt caagcagccc agttgtattg gacagggaag cccccatttt ttcagcaatg 865981 tcgctcactt tcaatgttcc atggttgttt aatagcatca gcaccttcat ttgcggcatg 866041 ctcatatcca gtttcatcca ctcggacaca tcaccgagcc cggcggacgt taagactttc 866101 atatagagca cccatatttc ccgttcctcc gatgaaagaa tgttttcgtt taagactgtt 866161 gtatcgtgta aattatattc catttcatca cttcctcatc attcactcct cttaccatat 866221 tactcgattt tcactcctga aagaaagtga gcagaaaccg catgcgggac tttgtccgaa 866281 aaataacggt agtgtataat gagttggaga ttattggggg agaggatcga actagaatat 866341 gattggagag accattgctg attaaaaaga atgctttatc aatattaaaa atcgtttttc 866401 ctattgctgt tttgctattt gttatttatc aatcgaaaaa agaactgaca aatctgtcat 866461 tcaaacgtac gctcatggtc atcaacggac tggaacgaac ggatttattc atgcttgtgt 866521 tgatcggctt gctggctgtt gcggctatgt cgctgtatga ttacgtcctg aagtactcac 866581 tgcgcctatc gatcacaaac ggaaaagttt tcagggtttc ctggatcgcc aattcattta 866641 ataatgtgtt gggattcggc ggtttagccg gagtcgggtt aagaatgatg ttctataagg 866701 agcatacgaa agaccataag gcactcgtga aaggaatcgc ctggctcaca tcatctatgc 866761 tgctcggatt atctgttttc agcattttcg ttgctgcgag agtgctgcca gttgatgaag 866821 tgattcatga gaagccttgg ctgtgggcgg tcgttatcgg ttttgcactg atattgccgt 866881 tatctttagc ggtgtccaaa ataaaagacc gcaaagctgg ggacgaagag aatgcggata 866941 aagtgaaaaa tccgattttc gcatatattg gagcttcagt tgttgaatgg ctcatggccg 867001 ggaccgtcat ctattttgct ttgttcgcta tgggcattca tgcagatatc aggtatgtgt 867061 tcggggtgtt cgtcattgcg gcgatcggag gaatgatcag cctcgtgccg ggcggcttcg 867121 gctcgtttga ccttttattt ttgctgggga tggagcagct tggctatcat caagaggcca 867181 tcgttacttc tattgtgttg tacaggctcg cctactcatt tatcccattt atcttgggac 867241 tgttctttgc cgccggcgac ctgacggaaa atacaatgaa gcggctcgaa acgaacccgc 867301 gcatcgcacc ggcaattgag acgacaaacg ttctgcttgt tgttcagcgt gcggtattag 867361 tgagaatttt gcaaggctcg ctttccctta ttgtgttcgt agcaggtctg attgtcttgg 867421 cctcagtttc cttgccgatt gacaggctga cggttatacc gcacattccg cgcccggcgc 867481 ttttgctgtt caacggcctg tccttaagct cagcgctcat tctgctcatt ttgccgatcg 867541 agctttataa acggacaaaa cgttcctaca cgatggccat tacagcgctt gtcggcggct 867601 ttgtgttcag ctttttaaaa gggcttaaca tcagcgcgat attcgtactg ccgatgatta 867661 tcgtattgct tgtgctattg aaaaaacaat ttgtccgcga acaggcatcc tatacactgg 867721 gacaattgat attcgctgtg gcgctgttta ctgtggcgct ctttaactac aatctgatcg 867781 cgggctttat ttgggaccgg atgaagaagg tgctgcgtca cgaatatttc gtccacagca 867841 cctcgcatat tacacatgca accatcatgg cgatcatcat tgtgccgctg ttcttcttga 867901 tatttacagt ggtctatcat aagagaacga aaccgatcgg agagaaagct gaccctgagc 867961 gtcttgctgc gtttctcaat gaaaaaggcg gcaacgcgct gagccatctt ggttttcttg 868021 gagataagcg gttttatttt tctagcgatg gaaatgcact gcttctgttt gggaaaatcg 868081 ccagaaggct ggtcgtgctc ggcgatccat ctggccaaag agaatcattc ccgctcgtgc 868141 tggaagaatt tctgaacgaa gcgcatcaga agggattcag tgttttgttc tatcaaattg 868201 aacgagagga catggcgctg tatcacgatt ttggctacaa cttctttaaa ttgggtgagg 868261 aagcatatgt agatttaaat acatttacct tgactgggaa gaaaaaagcc ggccttcggg 868321 caatcaataa ccgctttgag cgggaggagt atactttcca tgtggatcat cccccatttt 868381 ctgatgcgtt tttggaggag ctgaagcaaa tctcagacga atggctcggc tcgaaaaaag 868441 agaagggatt ctcgctcgga ttttttgatc cttcctattt acagaaagcg ccgatcgcct 868501 atatgaaaaa tgcagaagga gagatcgttg cattcgcaaa tgtcatgccg atgtaccagg 868561 aaggagagat atcggtcgat ctgatgcgct atcgcggcga cgctccaaat ggcattatgg 868621 acgcattgtt tatccgtatg tttttatggg caaaggaaga gggctgtacg tcatttaata 868681 tggggatggc acccttggcc aatgtcggca ctgcctttac atccttctgg tccgaaaggt 868741 ttgccgctgt catttttaat aatgtcagat acatgtacag tttcagcggc ctaagagcct 868801 ttaaagaaaa atataaaccg gagtggcgag ggaaatactt agcgtatcgg aaaaacagat 868861 ctctttctgt caccatgttc ctcgttacac gtctgattgg caaaagcaaa aaagactccg 868921 tctaataaga cggagtcttt ttttatttcg tttttaagaa gtaggtttca atatcatcaa 868981 gcaggtagtt tgcggcttta attccgcctg cggttgtcca tacgacgtca tcgacttcat 869041 gtgcattacc tgacttcacg gccttcaggt ttttccatag tgaactgctt gtccactgat 869101 tggcccattt ttcattttct tttgcattat cggctttata agtgaaataa aacagcacat 869161 cagcatccat atcaggaata gattctttac tgtcggttga gaacgtaaat tggtcctttt 869221 gtttcttaaa cagttccact tgtttttcag ggcgtttgaa gccaagctgg tctaaaataa 869281 tcccaggaaa tgaatcggta taatagattc ttgattcacc ggataaaaag cgtacgactg 869341 aaacggtttt gtttgtctgg tcgcccagct tgttttttaa atcagaaaca cgtttatcaa 869401 aatcggcaat gacttccttg cctttgtccg ccttattcac cgcgttggcg tatagagtca 869461 ggttatcctt ccagttcccg gccaaagatt cagcaaaaac agtcggcgca atcgcattta 869521 actgatcata aattttttcc tggcgcactt tgtttccaat aatcaaatca ggctttaatt 869581 ctgcgatggc ttccacattc ggttccgttt caagaccgac gtttttaaca cctttcatgt 869641 catctttcag atagtcatac cacgggtcgc ccttccatga ctttacggct ccgaccggct 869701 taatgccaag cgctaagagc gcctctgttc cttcattagt taaaacaaca atccgttttg 869761 gattggcggg gatgttgtct gatgtcccca ttgcatgttt gaccgttctt gttttgctgc 869821 ttgacacctc gctgttgctt gaactttctg aactattaca ggcagaaagt accataacgg 869881 ccattaaaaa tacgaatagc atgctgatat gctttttcat ctttttcctc ccaatattga 869941 aattcattat catttagatc ataataagca gtgttaagag tgtcaatccc taattgagga 870001 ttattctcaa aaacaaacat tacatagtaa ataactagga gaattagatc atgatctgca 870061 aaaaggcatc ttcaaaatgg attgtgttag tatgtctgat tttcatttta ctgacggctg 870121 tctgcgcaag cgtcgtgtat ggctatacag gtacgtcatg gagacaggtc tatcaggcgt 870181 ttacttcctt caatggaaca aatgagcatg tcatcatcaa ggatgtcagg cttccgcgcg 870241 ctttggttgc gacagtcgtc ggcgcctcgc ttgcagccgc gggcgctctc atgcaggcgc 870301 tcacaaaaaa tccgcttgcg tcaccgggga ttttcgggat taacgccggt gcaggttttt 870361 ttattgttgc cggatcgttt tttctgcata ttcagtcacc tcaggcatta gtatggagct 870421 cgtttctggg ggcagcattt accgctgcga tcgtctatgc agcaggctcg cttgggaggg 870481 aagggctgac gccaatcaaa ctgacgctgg cgggagctgc catggcagcc atgttttctt 870541 ctctgacaca gggcttgctg tctgtcaacg aactcgagct tgcccaggtg cttttttggc 870601 tgactggctc tgtgcagggc cggagtctgg atctgttgat gacgatgttt ccatatgcag 870661 cggcagcgct ggtaatctgc ttctttctcg gccaaaaaat taatctcctc gttatgggag 870721 aagatgtggc aaaaggactc ggccaaaaaa caggcctgct gaaatttgtg atggcgcttt 870781 gtgttgtcat gcttgcaggg tccgctgtcg ccattgccgg gccgatttct tttatcggca 870841 tcattattcc gcattttgcc cgctttgtcg ttggtaatga ttatcgctgg gttctgccat 870901 tttccgctgt tttgggtgcc attttgcttg tttgcgcgga tatcggtgcg cgatatatca 870961 ttatgcctca ggaagttcct gtcggggtca tgaccgccat catcggaatg cctgtgtttg 871021 tgtacatcgc aagaaggggg gcgaagctat gaaacttcgt tttggcgtta ctgcggctga 871081 aaagaaagca tggatcgtct ttttggtttt actggggtta acagctgctg tactcatcat 871141 aagcgctggt ctcggacaaa ggtttattcc tccctgggat gtagcaaaaa cattctttgg 871201 tgcaggttcc aagctggatg aactgatgat catgtcgttc cgcatgccaa gaattttgac 871261 ggctttatgc gccggtgtct gcttggcagc ggcaggcgcg atattgcagg ggctcgtcag 871321 aaaccctctc gcatctccgg atattatcgg aataacagga ggagcggcgg tagcggtcgt 871381 gcttttaatg atgttcttct cagaccgcag cagttcactt acgatcagtc tgtcatggct 871441 tccagcagcc gcatttatcg gcgcatcggc tgtcgggctc atcgtctatt tactggcata 871501 caaaaatggc gcctccacat ttcggctggt gcttatcgga atcggatttt caatgtcggc 871561 gcaggcgatg actaccctgt tgatgatcaa aggcccgatt taccgagcat cacaagccaa 871621 tgtgtatatc actgggtcag tttatgggtc aaactggcag catgtaaaaa tagctattat 871681 cttatctgtc attctcttat tcatttgttt tgtcgcgcta aaaaatatga atatacaggt 871741 gctgggtgaa gatattgcgg cgggtgcagg aagcgctgtg cagcgaaatc gttttttctt 871801 gctccttttg agtacggctc ttactggttg tgcagtttca gttgccggca caatcggttt 871861 tgtcgggctg atggcgcccc atattgcaag acggcttgtc ggctcatctt atggcgcgct 871921 gctcccagcg tcggcactta ttggagctct gctcgtttta acagctgata tcgtcggcag 871981 aaccttattt gctccggtgg aagtgccggc cggcgtcttt acagcggcta tcggcgcacc 872041 ttattttatt tatttgctct ataaaacaag aaattcttaa tcgttacacc cattttctta 872101 aaaaagaaaa tgggtttttt tgataatgac tgaagattcg taattatttt tgctatactg 872161 acagagacat tgataaagaa agggcggcag atgaatgaaa gaagcagagg tattaaaata 872221 tgaagcattt acaagcagtc ccggcaaagg aaaccccgca ggcgtcgttt tgcagggaga 872281 cgattatacg gaagacgaga tgcagatcat agctgaacgt gccgggtatt cagaaacctc 872341 ctttatccga aaaagcgagt cggccgatct tgaactccgt tactttaccc ctggacacga 872401 aatgaatttg tgcggtcatg cgacagttgc ttctctttac gcattatgtg agaaaggaat 872461 gctggagagc ggtaaaacgt acagcatcca aacgaaagcg ggtatcctgc ctgtgaagat 872521 ttctgaaaaa gatggccgca ttcatatcac gcttgaacag gcctctccgc aattcaaacc 872581 atttacaggc gatcggaaaa aacttgcgga cgcactgggt atcaccgatg aagattttca 872641 tgaagacctt ccgattgtgt ttggcagcac tgggatatgg acagccatcg ttccgcttaa 872701 atcattggag gcttccaaaa aaatggtgcc agataacaaa caatttccgg aagtgttagt 872761 tgatctgcca aaagcttcag tccatccgtt tacctttgaa accgtccatc ccgacagcga 872821 cctgcacggg cgccactttt catccccgta ttcgggaacg attgaagacc ccgtgaccgg 872881 cacagcatcc ggcgtgatgg gggcttatat gaaacattat ggcaatgccg agcagcataa 872941 atttatcatt gaacaagggc aggaaattgg aaaagacgga aaagtggaga tcgaaatgaa 873001 cgaagccggc ggccatgtga aagtgaacat gacaggaaca gccgtttact cagaaacccg 873061 tattcttaaa atctaatacg gatgatggtt tacaaaaaga tgcactttcc gttatcatta 873121 tgaaatgata atcattttca attgcatagg aaggtgagac ggtatgcctc aaaccgaaca 873181 aatacatcag cattcagtac tgagggacat catacgcagc agaagatcga ttcgaaagtt 873241 taaacaagag ccagtacctt cagcagtcat tcttgacatg cttgaaacgg caaaatatgc 873301 gccaaatcac agagtgacag agccatggag atttatttac gtttccagtg agacaggtaa 873361 agcgaacctc attaatacat ttgcagcgtt ctctaagaaa tccaagccgg atatgacaga 873421 ggaaaagctt caaaatttca aaaacacact tgggcgcgtt ccgggatttc tcctcgtcgt 873481 gtttcaggaa gatgaaaacg aaagagcgcg ggacgacgat tttgcggcaa caagctcgtt 873541 gattcaaaat cttcagcttc tcgcttggga aaaaggaatc ggcatggttt ggaaaagcgg 873601 aaaaatcctt tatgacaaag aagtccatca ggcctttggt ttacaggata atgagcgttt 873661 cgccgccatc atacaaacag gttatcctga cgaggcgccg gaagtgaaaa aacgcacacc 873721 gatccgcgac cgattcactg aaatgtaaaa aaccccttgt ctcaaacgga gacaaggggt 873781 ttttcattaa cgagatttct ttttcgctct gttgtcggct gctttcgcac gctcttgcgc 873841 ttcgcggtca tctgcatcag caagctcggt tgaatattct tcgtaaacgc cgtcagtttc 873901 cctttttaag gcatcgggaa cttgtggaag cttttgtttg tttttatcac ggtttttgtg 873961 gatatgattt ctgcccatat caaattcccc ctaaaaagtg atatcaaaca aatatagtat 874021 ttggttttaa ggggctatgt attcctactt ccgcttagca gctttttccg cttttttaaa 874081 ttcgcctgaa taaagaactt cctgcatttt tttcaggttg gcgccttgct ggtgcttctc 874141 cctctttttt tccataaaaa ggacctcctt caaccatgtt attcttaagg ttgacgcttc 874201 ctgctgtttt tatacagtct ttcggtccgc tatcagctgt gagagtgcaa attcaagatc 874261 cgaatatgta aaacgaaatc cagaggttat cgcttttttc ggaagagcgc gctgtccttt 874321 cacaatcaaa agactcattt cacccaatgc ttttgataaa aagaattccg ggacggggag 874381 ccagtgcggg cggtgcttca cccgtgcaat cgtttttccg aattgcttca tgtccacagg 874441 attgggcgcg gtgacattca ttgggcctga gatgccggcg ttttccaccg catatcggat 874501 catctgggcc gcatcctcga catgaatcca tgacagccac tgccttcccg ttccgatcgt 874561 tccgccggcc agaaacttat aggggagaat catgagcggg agagcgcctt tttctccaag 874621 catcacgcca aatctcgcat aaactgtccg gatgcccatc gcttcaatat gctgtccttc 874681 cttttcccac aggtgtgcag tatggctgag aaaatcctca tctgacgttg cagaatcctc 874741 tgtgaaagtt ttctcaaggc ttgtgccgta aatgcccacg gcactggctt ggatcaatgt 874801 cttcggcttc tccttctgtt tctgaataag ccgctgcact tcacgcgtcg cattgatacg 874861 gctggagaga atgtgctgct tcgttttttc tgtccagcgg ccaaaaatcg attttcccgc 874921 aagatttatc cagacatcaa tatgaggaag ttcctgctcc ggtgcggctc cttccgacag 874981 ccattggaca tatgtcatat ttttttgttc agtttccctt gcgtttcttg ataaaatata 875041 aacatggtgt ccctggcggg taagaacgcc tgtcagatgc tggccgagaa aaccggttcc 875101 gcccgtcatt gcgatattca tgaacatctc tcctcatcgt tctaataaat atactttacc 875161 tcattgtaat aaaagaaaac gcgtttcagg cctgagaagg gagattaaga tgccgtttat 875221 tacaaaaata tcaacgcaaa aaaagaatac ggaacgcttc aatatttttc tggatgataa 875281 atacgccttc agcgtggacg cggatgtgct cgtgaaattt gagctcaaga agggaaaaga 875341 actcgatgat cttgacatca ttgagattca atacggcgat gaagtgaaga aaggcttcaa 875401 ccgtgcgctt gactttttat cctatcgaat gcggtcgacg aaagaggtcg aggatcactt 875461 aaagaaaaaa gaaacctcgc cccccgtcat tgcggaagtc atccataggc ttaacgatta 875521 caagtactta aacgaccagg aatttgccgc agcctatgtc agcactcaca aaaaaacaaa 875581 cggaaaaggc cctgatgttt tgttcagaga gctaagagcg aagggaattg atgacgatac 875641 aattaaggag gcgctaagtt ccttttcctt tgaagatcag acaagagaag cggtcaagca 875701 tgttgaaaag cttctcaaaa aagataaaaa gctttcgacg aaagaactca aacagcgcgc 875761 ccagctgcag cttcagcgca agggcttctc atttgatgtt atcagcgcgg cgatggatca 875821 gattgaatat gaaaatgatg aagacacaga gaaagaagcg ctgcgccttc acgcggaaaa 875881 agcgtttaga aaataccgct atgacggctc atatgaaagc gccatgaagg tcaaacaatt 875941 tttattccgc aaaggattct cactcgattt aatcgagcaa ttactgcagg aagaggagta 876001 ctgaaatgga gaaacgatac agtcaaatga caccgcatga actcaatacc gaaatcgcat 876061 tactttctga aaaagcaaga aaagccgaac agcatggaat cataaacgaa ctggcagtgc 876121 tcgaacggaa aattacgatg gcaaaagcat atttgctgaa cccggaagat tactcaccgg 876181 gagaaacata tcgtgtggaa aacactgagg acgagtttac catcagttat ttaaatggcg 876241 ttttcgcatg gggatacagg acctcttccc ctcagcaaga ggaagcgctg ccaatctcag 876301 tattgcaaga aaaagaataa agcgtaacag gaggctgatg atcagcctct ttttgtttgc 876361 agcacattta cacgaattct taaagaaaaa atcattgaat tcacttgaaa aatcttttaa 876421 gatgaaactc gttgtttttt aaaatcaaag gaggcgatga cgttgagtat caaaaaccca 876481 tctgtaaaat ttattatatt tgttcttatg atttgtacat tttcaatcgg ctatacagaa 876541 tacgcggtga tgggtatttt gacgtcgatt gccaatgact ttcatataca ggtttcatcc 876601 gcagggcttc ttgtcacggc ttatgcggca agcgtttgtt tgacagggcc gctcgtcacc 876661 atcatttccg tcaagcttcc gagaaagcct gtgcttcttg ggctgatggc gatatttatc 876721 ctttccaacc tgatgagcgc actggcgccg aattttgcgg tattggccat ttcaagaatt 876781 ttatctgcgt ccattcacgg cgctttcttc gcgattgcca tggtattcgc aagtgaaatg 876841 gttccgccgg aaaagcgtgc tgcagctgct gcttcaatga acggcggact gacagtggct 876901 ctaatgcttg gtgttccatt cggctcttat ctcggagatg tcctgaattg gagagcggtg 876961 ttttccatca ttacggcact tggtgtcatc ggatttttag gccttatggc tgccgtgccg 877021 aacagaaaac caaaagtgat cccaatgctt atgaatgagt ggggtgtttt taaacacaaa 877081 caagtgctgt tttccttcgc gattaccatt ttaggctatt ccggtgtctt tatcgcctac 877141 acctttatcg aacccatttt gaggcattca gccggattca gcacggttgg cattacaggt 877201 gctctctttg cgtatggatt gggaggcgtt gccgggaatt tctttgctgg aaaggtaccg 877261 ctgcctttgc tgactcggac gatgatcggc gtaatgatcg gtttaatcgg tgttctggct 877321 gtatttcctt acatcgccat ttacccggct gcagccattg tggcaacgtt cctattcggg 877381 gcatgcgcat tcggcacgcc gcctcttctg caaacaaagg tcatttcctc atctgagggc 877441 ggcacaacca ttgccgcagc tgtcagcgta tcagcattta accttgccaa tgcccttggt 877501 gcatggatcg gcggaatgat tttaaacgga acaggctctt attcctggct gtttgcagga 877561 ggtgcgctta tgaccgcatg cggacttgtg ctttctacct tcgcacactt atcagaaaag 877621 aagagcgtct acgaatatca agtcaataaa gggtaaaaaa cagctgcagt gtatgcagct 877681 gttcttcttt accgtttgcc tgaggctctc attctttctt gaggatgctg attgatagat 877741 ccgtcagcac gctttgaagc atagtcgtcc tttgctctcg gttcaccctg aaatttgttt 877801 tcgttttcgt aaggaaatcc tttttcttta tttcggacca tgtcatatcc ccctaggttc 877861 gagatcaaaa agttgcgtct tttcagatga agacgtaagg ttagtatatg gagaacacca 877921 cgtaataaag cgttattttt ttcctgaaga aaggagactg cacacatgaa tatgtacatt 877981 gagaaactga ctaatctgct tctggaaaag aacgagatga tcagctatat acaggcaaaa 878041 acgtgggtgg aattgttatg gagcgatttc gaagcaacct acgcaaaagc cggacacgcc 878101 tatcaaggtg aaaaaatgac tgaaaaaatc gtcacacaat ggattgaaaa ctatggcggc 878161 cagctccacc tttttcaaag ctcccgtaac gacgtgaatg attacttaaa tcaaagcaga 878221 ggccttttgc attaaaaacc tgccgttaac gaccggcagg ttttttcatt ttcttaaaat 878281 taccttaaca ggaagaaatc ataaacaaaa catgtttcac cagcctgtca atcagggaat 878341 accacttata tcttgtcaaa atgcgaggag gagctttata tgaaaaagaa acaagtaatg 878401 ctcgctttaa cagctgccgc aggactgggt ttgacagcac ttcattccgc tcccgcagca 878461 aaagctgcgc cccttcacga catatctgtc agcatgccat catccgatac ttacatcata 878521 aaagcaggaa agctgaatgt ccggactgag ccaaatcatg aaggtgatat tctcggcact 878581 gtatcatcag aacaaaaggt aaaagtcgat aggttcgtaa atgccgattg ggctcaaatt 878641 catttcaaag gaaagaaagc atatatttca actcactttt taatgaaaac cgcaagccaa 878701 gcgaaaacaa cgaaacagac agccttctat acaccgacgc ccgaaaacgg aaaagctaag 878761 cagctctcat ctggaacaga ggtgacaata cttgggtggg gattcagtga aaacggcgga 878821 tttgacttca cttgggcgtt cgtggattat ggcggagtta aaggctatat tcacacaaag 878881 gatttacaaa tgcgataaaa aggcaggccg aggcttgtct ttttgcctat gcatgaaaca 878941 tttcttcttt ctgcacgtaa caatgagaaa ggagatgatg atatgacggg tttagtcggc 879001 ggagggctta tgatcattgc gggcatactg atcaaactgt ttcctcccaa atcgatcaac 879061 agtgtgtacg gatacagaac gagacgctca atgtcagatc aaagattatg gaatgaagcg 879121 aaccgttaca gtgcatcatt aatgatcctg tcaggcttgg tgattgcggg aatgggtttg 879181 ctgctgggat caaacttgtt tattcttcag cttatcctgc tgattgccgc ctgtgtcata 879241 acatttatgc taacggagaa aaggctgaaa atcatgacgc acagtcaagg aggagataga 879301 agtggacgga gttaaatgcc agtttgtcaa tacgaacgga atcacgcttc acgttgcagc 879361 cgcaggacgg gaagatggcc cgttaattgt cctgctccat ggatttcctg agttttggta 879421 cggctggaaa aatcaaatca aaccgcttgt tgatgcgggt taccgggtca ttgctcctga 879481 tcagcggggc tacaatctca gtgacaaacc ggaaggaatt gattcgtatc ggattgatac 879541 attaagagat gatatcatcg ggcttattac gcaattcact gatgaaaaag caattgtcat 879601 cggtcatgac tggggaggag ctgtcgcatg gcatttggct tccacacgcc cggaatatct 879661 tgaaaaactg atcgcgatca atatcccgca cccgcacgtc atgaaaaccg taacgccgct 879721 ttatccgccg caatggctga aaagctcgta tatcgcatac ttccagctgc ccgatatacc 879781 ggaggcatca ctaagggaaa atgattatga tacattagac aaagcgattg gattatccga 879841 ccgtcccgcg ctttttacat ccgaggatgt cagcaggtac aaagaagcgt ggaagcagcc 879901 gggcgcgctg acagctatgc tgaactggta cagagccctc agaaaaggaa gcttggcaga 879961 gaaaccctct tacgaaacag taccttaccg aatgatctgg ggaatggaag accgcttttt 880021 gagcagaaag cttgcgaaag agacggaaag gcattgcccg aatggacatc tcatctttgt 880081 tgatgaagct tcccattgga ttaaccacga aaagccagcc atcgtcaatc agctgatttt 880141 ggaatatctt aagaaccaat aagctaaaat ttctctccat ccgtctgtca taatggcaga 880201 ctttttctgt gcgttttttt tcatagtctg ttttaaacat gacaaaataa cattaaaaat 880261 catgaatgtc accataaaat tgtaacaaaa aacaggttta aacgacttta aaaaaaggaa 880321 tagccttact gaagatttgt gtaaaactcc cctaaggcaa tacttaaaaa gaataataaa 880381 aagaaggtgc cttaatgaag caaggattaa tctcgattat tatcccgtct tacaatgaag 880441 ggtataatgt taaactcatt catgaatctt taaaaaagga atttaaaaac attcattatg 880501 actatgaaat attcttcata aacgacggaa gtgttgatga cacgcttcag cagatcaaag 880561 acttggcagc gacgtgcagc cgggtaaaat atatatcttt ttctcgaaac tttggaaaag 880621 aagccgcaat tttggcgggc tttgagcatg ttcagggcga ggcggttatt gtcatggatg 880681 ccgatctgca gcatccgaca tatttgctga aggaatttat caaaggctac gaagaagggt 880741 atgaccaagt cattgcccaa aggaacagaa aaggggacag ctttgtccgc tcactcttat 880801 catctatgta ttacaagttc attaataaag cggtggaagt cgatttgcgt gacggtgtcg 880861 gtgacttcag attgttaagc cgccaagctg tgaatgcact tttgaagctg agcgaaggaa 880921 accgcttctc aaaaggcctt ttttgctgga ttggctttga tcagaaaatt gtattttatg 880981 aaaatgtcga acgaaaaaac ggcacctcca aatggtcgtt cagcagtctg tttaactacg 881041 gaatggacgg cgtcgtttca tttaatcata agccgctgag attatgtttt tatacaggca 881101 ttttcatcct gctgctttcc atcatttata tcattgccac attcgttaaa attctgacta 881161 acggtatttc tgtgcctggg tatttcacca ttatctcagc agtgttattt ctcggcggag 881221 tacagctgtt aagtcttgga ataataggtg aatatatcgg ccgaatctat tatgaaacaa 881281 aaaaacgccc gcattatttg atcaaagagg cgaatatccc gaacaaagac ctgcctgaaa 881341 cgaacgaatt aaaaagcatg cggcgtctga caaaaatgca ctgaaaatac caagcgccat 881401 tggcagtgct ttttttgcgt gtctattatc ttaaaagcaa gactggagaa ttcatatgaa 881461 aagaaaacat atcatgatct atgcggccag tttgctggtg tccgttctgg cacacgcttt 881521 ttttgtgaaa gaatgggcgg aaggcaggta tatgacaggt ccgggtgacg ggcttgcgca 881581 aatgatcgta tttaaaaaat tattatttga ccaatataca cacgggaatt ttttctacaa 881641 ttattcattc ggacttggcg gcggcacatt cagtcagctc ggctattatt tttctgcgtc 881701 ttttcttttt cttgctgtgt ctgccgctgt ttggctgctt caagccgtcc agctgatcgg 881761 agaaacggat acgctttttt gggcagagtc agctgttttt atcagtattt tcaaattgag 881821 cttgatcatc tttacgtccg cttctgtttt tcattatctt cttaagcaca gggcggcatc 881881 gttcacggga gccgtgttat acggcgtctc aattatttat ttccgtcacg aagcgtattg 881941 ggaatttttc accgatacaa tggtttggct tccgctgctt gtgcttggcg cagaaaaaat 882001 tattagagag cggcgtccgg cgtggtttat cgttgcgtgt tcgctgacgt taatcaacaa 882061 tttttacttt gcatacataa accttatatt catcggaatc tatgtgctgt tcagatggct 882121 gatccgtttg gaaccacatg aagagaaaag atggattcaa atcagattat ttctcgtttc 882181 aggcttcatt tcttttggca tcagtgcggc ggcgtttgtg ccggtagtat acggtttttt 882241 aaacaacctg cgccctccat acagccagaa aatagagtgg ctcaatttcg atgataatat 882301 cttattttcg agccggatca tcattgtgcc ggccgctttt ctgctgtttt tgtttattat 882361 ttctttttac aaaaaccgtg tgtttcgtct ctttgccggg ttgagcctgc tgtttattct 882421 gtttcatttc agtccgtatg cggcaagcgt ctttaacggt ttttccgccc cgcaaaaccg 882481 gtttgaatat gttctggcct ttaccattgc gggagcagct gcggctggtt tgtcacagct 882541 gtctgaattg aaacggaaag aactgctccc ggccgcagct gtcgtcctgc ttctttactt 882601 gtatcatatc caaaggtata agctcgatat atggaagcct gcgaatgaaa gtattctatt 882661 gctcttactc atgacaatcg cagccttgtt tgctgcagct tttgcgaaaa aacgggcaaa 882721 aatggctgtg tacggtataa tcattctttc ttcgctgttt gtcgccaact cctatcaaaa 882781 atacgcgctc tcagaaggcg gcgatttgga cagtgtgaca aaagaatatc ttacaagtga 882841 ggaatacaga gggcgggaat catctgagct catcagacgt ttacagaagg aagacgatga 882901 cccgctcatg agaatcgact ggatgaacgg ggtccgcaat aatacgccaa tcatttacgg 882961 atttaatggc ttcagcgcgt attccagcat tttaaacaaa gatctgctgg ccttctattg 883021 gaatgattta agcatcgata tgggcaggga aagcgtcagc cgttacgcgt cattgggaga 883081 cagggcgaat ttatacagcc tgctttacgg caaatattat atgaccgaaa aaacaaacga 883141 agccagcgtc ccgtacggct tcaaaaagca tttagaaaca gagcattatg cagtttatga 883201 gaatcagtac atgcttccat tcgttaaaac agcggatgcc atatacagcg aaagtgagct 883261 ggaccgattg cccgctcttg cgaaagaaca ggcgatgctg aaaggaatta tattaaaaga 883321 tccatcagga aaaacggagc agacaccaaa accgtccaat ttgatcacca agtcggacat 883381 caccgcaaaa caagcccagt atcaaaacgg gctgctaacc gtaactggag aaaacggagg 883441 agagctgatc atcaccccga aacagccatc atccgctccg ggagactact atgtcagctt 883501 ttatttgaaa agcaaagcaa aagacaaagg atttacatta aaggtaaatg attatgtcac 883561 aacaaggaaa tcgaacaaat cgatctataa aaccggagta aataatataa cggtaagagt 883621 gcctaaatca ggccatatct caatcaatct tccgaaagga acctatgagc tgagaaacat 883681 agcgctctat gaagaaaatt accaaacgct gaaaaacgct gtaatgcaaa ataaaacaga 883741 gaaagcagac aaactgaatt ggaacaaaaa tcgactgacc ttttcctatc atctgtcaaa 883801 agaccagtac atcatgcttc cgatcccata tgaaaaaggc tgggagctga agatcaacgg 883861 aaaaacacag aagatcgaaa aagcggatta tgcttttata ggcttcaagg cgcaaaaggg 883921 agacaatcac attgagctga cttactatcc gccatacttc aaaatatcgg cgatcatatc 883981 tctcgtcagt ctgctgcttg ctgtttttta tataagacgt aaaaagcccg gctctatata 884041 gagccgagct ttaatttttt ctgaagtttt tcttcgctga atatccatcc cgtataggat 884101 gaacgaatcg tgagatcatg gccgatatga acaattgcga caaacggata atggcctttg 884161 ctccgataac gcaggtcgat aaatctcacc tcataatgat ctttaaacgt atccacttcc 884221 caccggtata ccggagaaaa ggacagaaac gccgcgatgt tatcatcctg ctttgccgca 884281 tgcattacat cggtttcagg aacaggcacc cgattaaatg tatccagaat cacgacatgt 884341 ccttccatgc ttcttcctac atagaaagca tgtgctgtcg tcactgcgat tcgccattgc 884401 ctgaatttca tcgttggaga aataataatg ctttcgatct catcatgaat catctcatga 884461 agcttccgtt taattctcag ctgcatgatc aggcgcacca agtagtagcc taccaatatg 884521 atatataagc tgagaaacgt gatgccggga ctcccgcctg cataccaaat cgcgatagct 884581 gccagatggc tgataaaaat aaacggatca aacgtattaa tcagcccgag cgcaacccat 884641 tttttcgaaa acggacgaat ggcttgtgtt ccataggcgt tgaatatatc aacaaagaca 884701 tgcagaacga ctgccagcag tgtccacagc cacaggtgca gaaaatcggc ctgaggataa 884761 aataaataca gaatcgccgg gatgatgaca gaccaaaaca aaacggcggg aattgaatgg 884821 gtaaatcctc tgtgattcct tatataaaca gcattgtttt taagctttaa cacagtatca 884881 atatccggag cctgagagcc cgcaagcgtt gcgatcataa cagcgtgagc cattgccgga 884941 tctgatccga caacaggatc aagcgtcgca ataccgccca gtgcgatgcc cataacgaca 885001 tgtgtgcccg tatccatagg tgacctcctt gcagggtgat cctgcacatt cactttgtaa 885061 gaaattcccc attttcatat acccaatttt taaactgatt caatcgttct catatgtttc 885121 cgctttttct ttattactat ttaatgtaac atattatcgt actgtgccct tagtgtacaa 885181 caaaaaacag tctaaagaaa agcggggcgc gaaagactgg ggagaaacac atatgaacgt 885241 acttgaagac aaattaaaac aaaaagacat acagcaattt cgcgatgatt taatctcatg 885301 gtttgaacga gagcagcgcg ttttgccgtg gagagaggac caagatccat ataaggtgtg 885361 ggtatctgaa gtgatgctgc agcaaacgag agtagagaca gtgattcctt actttctccg 885421 gtttgtagaa caattcccga cagtggaagc gctcgctgat gctgatgaag aaaaggtgct 885481 gaaagcatgg gaagggctcg gctattattc gcgagtcaga aacctgcaaa gcgcggtaaa 885541 agaagtgaaa caggaatacg gcggcattgt tcctccagac gagaaagatt ttggcgggtt 885601 aaaaggcgtc ggcccttata caaagggagc ggtgctcagc attgcctaca ataaacccat 885661 tcccgcggtt gacggaaatg tgatgcgtgt catgtccagg attctatcta tttgggatga 885721 tattgccaaa ccaaaaacaa gaacgatctt tgaagacgcc atacgagctt ttatttccaa 885781 agaaaaacca tctgaattta atcagggctt gatggagctt ggagccttga tctgtacgcc 885841 aaaatcaccc tcatgcctgc tttgcccggt tcagcagcat tgctcagcat ttgaagaagg 885901 cactgaacgg gagcttccgg taaaaagcaa aaagaaaaag cccgggatca aaaccatggc 885961 cgcgatcgta ctgactgatg aagacggaca agtgtatatc cacaaacggc cgtctaaagg 886021 tttgctcgcc aacctgtggg aattcccgaa tcttgaaaca caaaaaggga tcaaaactga 886081 gcgtgaacag ctcattgctt tcttagaaaa cgaatatggc atacaagctg atatcagtga 886141 tctgcaaggt gtagtcgagc atgttttcac ccacctggta tggaatattt cagtgttttt 886201 cggtaaagta aaacaagtgt cggataccag caagctgaaa aaagtaacga aagaagagct 886261 cgaacaattt gcgttcccgg tgtcacatca aaaaatctgg aagatggcag gagaagcagc 886321 cgccatctcg gctgctccgt aaaccattct taatcgtaag agacgcgcgt gccgtggctg 886381 tagtccgctt cattgcgctt cattccgccg cgcgcttcaa tttcttgcgt taattcccgg 886441 tattttgatt ggccttcttc gttcaaataa ggcataattt gctgaaaggc atgatgaaaa 886501 taagcgagtt cactgttctt ccaatctttt ttggaaacca tgttcaattc gctcatatca 886561 cgtccgacat acataacaga agaccccctt taaagttctt gccattattg tttgtggaaa 886621 taaaagaact atacgctaca aggagatgag gaaaaatgga acaaaataaa tgtgcactcg 886681 taacaggaag cagccgcggt gtcggaaaag cggccgcgat cagacttgct gagaacggct 886741 ataacatcgt cattaactat gcacgcagca aaaaagcagc attagaaaca gcggaagaaa 886801 tcgaaaagct tggcgttaaa gtgcttgtcg taaaagcaaa cgtaggacag cctgcaaaaa 886861 tcaaagaaat gtttcagcaa attgatgaaa cgttcggcag acttgatgtt tttgtcaata 886921 atgccgcttc aggagtacta agacctgtca tggaattaga agaaacacac tgggactgga 886981 cgatgaacat taatgcgaaa gcattgcttt tctgcgctca ggaagctgcc aagctaatgg 887041 agaagaacgg tggcgggcat attgtcagca ttagttcatt aggctctatc cgctatcttg 887101 aaaactacac cacggtcggt gtatcaaaag cagcgttaga ggctttaacc cgttatcttg 887161 ccgttgagct ttcaccaaaa caaattatcg tcaatgctgt ttcaggcgga gcgatcgaca 887221 cagatgcgct gaagcacttc ccgaatagag aagatctgct tgaggatgcg cgccaaaata 887281 cgccggcggg acgcatggtc gaaattaaag acatggttga tactgtggag tttctagtgt 887341 cttccaaggc tgacatgatc cgcggacaga caattatcgt tgacggcgga cgctcactgc 887401 tcgtttaaaa atttttaaaa aagaggaata gctatacgat cacctgcaca ttctaatgac 887461 cgtggaggtg ataacaatgg ctaactcaaa taacttcagc aaaacaaacg ctcaacaagt 887521 tagaaaacaa aaccaacaat cagctgctgg tcaaggtcaa tttggcactg aatttgctag 887581 cgaaacaaac gctcagcaag tcagaaaaca aaaccagcaa tcagctggac aacaaggtca 887641 attcggcact gaattcgcta gtgaaactga cgcacagcag gtaagacagc aaaaccaatc 887701 tgctgaacaa aacaaacaac aaaacagcta atcactgaaa cagaaaaaag cacttcatct 887761 tcgggtggaa gtgctttttt ctgtttgaaa aacgacaaaa cttgtggaag gtctacagaa 887821 tgagtcaaag ggtttgcttt atggagatcg aaatgattaa aggaggaaat gtttatactt 887881 tcatcaggct gaaggaggaa ccgatgaccg aatttgaaaa gctggtaagt gaacagatga 887941 aaacgatgga taagcttctc gatctccaat cagagctcga ccgctgcaaa caaattgagg 888001 cggaactccg gcatttggaa agggatgcaa ggctgcgtgg gattcaggct gaaattgcgg 888061 taaaacggaa acaccttgcc gatatacagg atatgtttca aaagcagaca gagcaggtca 888121 ttcgttcata tcgcagctca gaaaagccgt cttcctttgt gtagtgcagg aatgtgccat 888181 tccccggccg gaatggctct tttattttca tttttcaatt tgtaacgtta taataggtaa 888241 aagacgttgt cggtaagcaa atttggacat actaactgta gggctttata gaaagtaggg 888301 gagaaatatg ggctatccca aggaaggaga aaccattcaa attcacagct ataagcacaa 888361 cgggctgatt catagaattt ggaatgagac aacaatctta aaaagtacag aaatgtgtgt 888421 catcggagcc aatgaccgga cgatggtaac cgaatcagac ggccggacat ggataaccag 888481 agagcccgca atctgttatt ttcacgcaag acaatggttt aatgtcatcg ggatgctgag 888541 ggaagacggg gttcattatt attgcaacat cagttctccg tttgcctatg atggcgaagc 888601 aattaaatat attgattatg acttagatgt taaggttttt cctgacatga cctacaatat 888661 tctcgatgaa gacgaatatg atgatcatcg gaaagccatg aattatccaa aagaaatcga 888721 cagtatttta agagactact taaatacgct gctccattgg attcaccagc gtcagggacc 888781 gtttgcgccc gagtttgtcg atatgtggta tgaacggtat ttgcgctata caaaataatg 888841 gttacgtaaa aacctgttgc ggggtacaac aggtttttca catgggctca cacacatcat 888901 gataaagaga gagggggaat caaccgtggg ggttatgaaa cgctacatgc aattcgtcaa 888961 accttataag aagcaaattt tcgttacagt gttaatcggg atcgtaaaat tctccattcc 889021 gcttgctctc ccattgcttc tgaagtacgt agttgacgac attattcaag gaggcggcac 889081 ggccagtgac aaaaccacgt cattgttcac gattatggcg atcatgttcg ccttattttt 889141 aattttgcgc ccgcctgttg aatattaccg gcaatatttt gcccagtgga ctgccagcaa 889201 ggtgctttat gatataagag ctaagctgtt tgaccatata caaaaactga gccttcgttt 889261 ttacgcgaat acaagaacag gggaagtcat ttcccgagtg attaatgatg tagaacaaac 889321 aaaggatttc gtcatcacag ggctgatgaa tatatggctc gatatgctga cgattttgat 889381 tgtaatctct atcatgctca cactggacgt taaattaacg ctgatctcta tcgttttatt 889441 cccattatac ggaatatcag tgaagtattt ttacggccgt ttacgaaagc tgacaaggga 889501 gcgctcacag gctcttgctc aagtgcaggg gcatttgcat gaacgcattc aaggcatgcc 889561 tgtcatcaga agctttgcga tagaagatca tgaacaggct caatttaatg agaaaaacgg 889621 tcatttctta gataaagcca tccgccacac gaattggaac gcgaaaacct ttgcggtcgt 889681 taataccatt acagatttgg cgccgctcat cgtcatagcg tgcgccgggt attttgtcat 889741 taatggaccg ctgacagtcg gaacaatggt cgcgtttgtc ggatatattg acagaatgta 889801 caaccctgtt agaaggctga tcaattcctc tacaactttg acacagtcaa tcgcatcaat 889861 ggacagggtg tttgaattta ttgacgagcc ctatgaactc actgacaaac caaatgcgat 889921 aaaggccgat cagattcgcg gaggagtgga gtttcaaaac gtttcgtttc aatatgagaa 889981 ggacaaagaa aatattcttc atgatgtatc cttaaaagta aatagaggag aaactgtagc 890041 tctcgtcggc atgagcggag gaggaaaatc aacgctcgtc agcctgatcc caagatttta 890101 tgatgtaaca agcggcagac tgctgattga tgggacggat attcgcgatt atgaagcaag 890161 aagccttcgc aaccaggttg gtatggtgct tcaagatacc tttttattta gtgaaacgat 890221 tcgggaaaat atcgcgatcg gcaagcctga tgccacactt gaagagataa tcgaagccgc 890281 caaagctgca aatgcccatg aatttatcat gagttttcca gaaggatatg agacccgggt 890341 gggggaacga ggcgttaagc tttcaggcgg acaaaagcag cggatctcaa ttgcgcgggt 890401 attcctgaaa aatccgccgc tcctcatttt agatgaagct acatcagctc tggatttgga 890461 aagtgagcat tacattcaag aagcgatgga caaactggcg aaggatagaa caacttttgt 890521 tgtcgcccac cgtttatcga caatcaccca tgcggataag attgttgtca tggaaaacgg 890581 gacaatcatt gaaatcggaa cccatgatga actcatggac tatgagagcc aatacaagca 890641 cttatttacc attcaaaatt tgaactaaaa catcaatctt atatcctttt aacgaaggat 890701 ataagatttt tttgtatata aaaaaacccg gctgtttaac cgggttactc ttctgtttct 890761 atttcgcagt ctttcggatg atacgtttga aaacttgtga taagtgtttc taaatgttca 890821 agctgctcgc gatattccac ggcgcttgcc ataatattga gcatgttgta atcaataagc 890881 tcctcatccg tattctgctg attttttaaa aatgactttg ttaaaagctg cttataccgg 890941 atgccttctt caaccgcgtc atcatgcggc ttgatttttc cgacaaacct catcaaaatc 891001 cgctcgtgcc agtaaagcag gtaatcaagt tcttcagtca atgtttcctg aaactcttcc 891061 ggcatatgat agatctcgtt ttccagacga tgcagcttct tcaatgtatc aagcgcccga 891121 tttgcagtaa taatggcctg tctgaacagg acaagctttc ttgatttcac ataagtcgtt 891181 ttcttaaagt aacttctttc ttctttatat agaagatatg tctgatcaag cttgatcatt 891241 ttttctttca gtttttcaat atcctctttc aaaatcgaat gctctgtcga ctgccgcatg 891301 gacaatctga tccacttcat aatttcttcg gtgttttcga cggtattatg aatcagcttt 891361 gtttcgtact taggaggcaa aaacacaagg ttgacgataa aggaagaaag cacccctaag 891421 atgactgtgc ttgttctgat cagcgcgaac attaaaaagt cgtcaccggc agattctaat 891481 atcgcaatga ctgttacaag agcaattgaa attgtatgtt caattttaag tttcagcatg 891541 attgtaatga caataactgc tgttaacccg atcataatcg ggctgggtcc gaaaataagg 891601 ccgaacactg tggcaatcac agctccgatg atatttgctt gaacctggtc aataataatg 891661 agaaaagagc ggtaaatcga cggctggatc gcaaatatcg ctgcaattcc agcgaaaatc 891721 ggcgcgggaa gcccgatcca cgaagccaaa taaagggcaa gtgtaatcgc aatcccggtt 891781 ttgaaaatgc gggcaccaag tttcattggt ttgtgcgtgc attcctttct atagtaaatt 891841 gtgtgacata gcaaatgggc taatccttaa aattcccggt tagtttattt gctaaacaat 891901 taagtaatat acagggatcg atacaaatat tcaagctatt tttctagaaa aagaccaaaa 891961 tcttacacgc tgtttgattc cataaaaaaa caggagctca aagctcctgt tcaaggtatt 892021 tgattctagt tttttagatg tttaaatgca tcctcgaccg ctgtaagcgt gtctttaata 892081 tcctgctctg tatgtgctgt ggtaataaac caagcttcat acttagaagg tgctaaatta 892141 attccgcgtt ccagcatcag cttgaaaaac gtagagaatg tttctccgtc actccgttca 892201 gcctgctcgt aattttccac tttctcatca gagaagtata ccgtgagcgc accttttaac 892261 cggttgaccg taatggtgat gccgtgtgtt tctgcgtgct tcaaaatgcc ttcctcaagc 892321 atagcgccaa ggtgatcaag cttttcatac acgccttttt ctttgagcac ttccagacaa 892381 gcgatgcctg ataggatgga agcggggttc cctgccattg ttcctgcctg ataagcaggc 892441 cctagcggag ctacctgctc catgatttct tgtttgccgc cataggcccc aatcggaagt 892501 ccgccgccga taattttccc gagtgctgtt aaatctggtt tcacctgtaa gagatcctgc 892561 gcgccgccat acataaagcg gaaagccgta atgacttcat cgtaaataac gagagcccct 892621 gcattatgtg ttaattcatt tacttgttct aagaagccct ctttcggctc cacgataccg 892681 aagttgccga caatcggttc aacgagaacc gccgcgattt cactgcccca tttttcaaga 892741 gctgctttat agctatcgat atcattaaat ggtactgtga tcacttcgtt tgcaatgctt 892801 ttcggtacac cggctgagtc tggtgtgccg agagtagacg ggccggagcc tgcggcgaca 892861 agcacaaggt ccgaatgccc gtgatagcag cccgcaaatt taatgatttt tgtccggcct 892921 gtatatgcgc gagccacgcg gatggtcgtc ataacggctt ctgtacccga attgacgaat 892981 cttactttgt ccatagcggg aatggcttct ttgagcattt ttgcaaatgt aacctcgtgt 893041 ttcgttggtg ttccatacaa tacaccgttc tctgctgctt ttttaatcgc ttctgtaata 893101 tgcggatggg catgtcctgt aataatcgga ccgtacgccg ctaaataatc gatgtatttg 893161 ttgccgtcca catcccaaaa ataagcgccg cttgctttct ccattgcaac aggagaaccg 893221 ccgccgactg ctttatatga tctagacggg ctgtttacac cgccgacaat gtgctgtaat 893281 gcctcattgt gaagttcaat tgattttgta tgcaagaata aaaacctcct atatctccat 893341 gcgtcctttc tattgtagca tgcttccgaa caagaacaat ggcttcgggc ttcagattca 893401 gctgagatgg ttgtaatctg gacaagaatt ggatacgctt aataaaaaaa catccggagg 893461 taacgtaatg actatagaaa tcggacaaaa agcgcctgat cttgagttaa aaggtgatca 893521 tggggaaaca gtaaaattat cggattataa aggaaagtac atcgtgcttt atttttatcc 893581 aaaggacatg acaccgggat gtacaactga agcatgcgat tttcgggaca gtcacgaaag 893641 cttcgccgaa ctggatgccg tcattatcgg cgtcagcccg gacagccagg aaaaacacgg 893701 aaaatttaaa gagaagcata accttccatt tctgcttctt gttgatgacg agcataagct 893761 ggcggaagca tttgatgtgt ggaagctgaa gaaaaacttc ggaaaagagt atatgggaat 893821 cgagcgttcc acttttttaa ttgataaaga aggccggctc attaaagaat ggagaaaagt 893881 aaaagtaaag gaccatgtag ccgaagcgct tcaaaccctc aaagatatgt ctgaaaagta 893941 aatctctatg agcctatgct tacttttacc ctgatatcaa ttgacaaatt atcgtagaaa 894001 gagttacact aattataaac attacaatgt aagaattttt tttagaagag aggtgcatga 894061 cggatggctg cacatgaact aaaagaagcc ttagaaacgt tgaaggaaac cggagttcgc 894121 attactcctc aacgtcatgc gattctggaa tatctcgtta actctatggc tcatccaaca 894181 gcggacgata tatataaagc tctggaaggg aaatttccta acatgagcgt agcgacggta 894241 tataacaatt tgcgtgtgtt ccgggaatca ggtttggtaa aagagctcac atacggtgat 894301 gcttccagca gattcgattt tgtcacatcc gatcactatc acgcgatttg cgaaaactgc 894361 ggtaaaattg tggacttcca ctacccgggc cttgatgaag tggagcagct cgctgcccac 894421 gtcacgggct tcaaggtaag ccaccaccgt ttagaaattt acggcgtctg ccaagagtgt 894481 tcgaaaaaag aaaatcatta aaaataagct gaccgcacga aacggtcagc ttattttatt 894541 tcgacatttt ctttttatta taagactcat caaattcttt tccttctaat cccttatcta 894601 aagtcagcgg ctctcggcaa tgcatgcaca tatcgactac tcctaaaacc tttgtctctt 894661 tatcacagcc tggacaaatg acgcgaaccg ctttagtcga aagcattccg atccaaaagt 894721 aaactaccgt gctgagaccg atggataaaa gcccaagtat cataaacaaa ctagaaagca 894781 aaactgactc tttgaaaaag atcccgatgt acataatgat aaacccaacg aaaaccaaac 894841 ttaacgcaaa tgttctgatt ttattaattt tgctggagta tttcgccatg tccatccccc 894901 tctgttttaa ctatagcaca aacccgatgg gattttcttc atgttttcgg ttgaactgga 894961 atttacatat ggagagttac tgtgaaattg tttataatag ttcaatgtgt ttagaaaaaa 895021 ggaatttcgt tttaaccata gaattgaatc aaatagagaa taaaaaaatt tgaacaattg 895081 cattggagga atagtgatgg aaaatcttct ccgtccaatt taccaagaaa gagcaagtca 895141 ccccaataca ttggctgtca ttatgattga gagaagaaac aaaacatctt ccttaacaga 895201 taactttgat gcagctttgc tggtgattgt aaaggatgct gatgagccag tttttataaa 895261 gcattatgaa tttgatcatc aaacagcttc tttgcatgtg gtaacagatt ctcagattca 895321 agaatggatt ttgcttggaa caaatagaag aatcatagat tggattgtaa atggcagagt 895381 cttgtttgac cgtaatgaat acgtagttga actgattgac aggctgaata catttccgtt 895441 tgccgaacgt aaactgaaga tcggactcga atacggcaaa ttaatcagaa ggtatgttga 895501 agggaaagct ttttttgaag ccaatcaatt tttagatgcc tacaatgccg ttgttcatgc 895561 gctgcatcat ttagcacgta ttgaagtaat cgacagagga ttccatcccg aaaccacggt 895621 gtggagccaa gtgcgccaga tggagcccca agtgtacaaa ttatattccg agctgattga 895681 aagtcatgag agcctggaaa aaagacttga attattattc ttagcaaatg attttctcat 895741 ccattccaaa gccgagatcg gttcggcgca tcttttcgaa gtaatgaaag aaaaagacat 895801 ttggcaattc ggtgagcttc ttcaacatca tgacctaaag cactttaccc aagatcttgg 895861 cgttatgctt gattacttga cggaaaaggg acttatcaac gtctgccaga tagaaacgaa 895921 aggacaggct gtctatcacc gaggatattc ttttaaaaaa ggtgttgact ctgattcttg 895981 accgtgttat attattaaac gtcgctgatg cgcttctgag aaaacaagct cacagcggcg 896041 ggaaaataaa tcaaaaaaac atttgacaaa agaaagtcaa aatgttatat taataaagtc 896101 gcttcaacaa gaagtgaaaa tgatctttga aaactaaaca agacaaaacg tacctgttaa 896161 ttcagttttt aaaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga 896221 cgcaggtcac acaggtgtcg ccgcaggatg cggtgaactt aacctgtgat ccatttatcg 896281 gagagtttga tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag 896341 cggacagatg ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta 896401 acctgcctgt aagactggga taactccggg aaaccggggc taataccgga tggttgtttg 896461 aaccgcatgg ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc 896521 gcattagcta gttggtgagg taacggctca ccaaggcaac gatgcgtagc cgacctgaga 896581 gggtgatcgg ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag 896641 ggaatcttcc gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt 896701 tcggatcgta aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct 896761 tgacggtacc taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta 896821 ggtggcaagc gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc 896881 tgatgtgaaa gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc 896941 agaagaggag agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac 897001 cagtggcgaa ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc 897061 gaacaggatt agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg 897121 gtttccgccc cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg 897181 caagactgaa actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta 897241 attcgaagca acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata 897301 ggacgtcccc ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt 897361 gagatgttgg gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag 897421 ttgggcactc taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat 897481 catcatgccc cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc 897541 gaaaccgcga ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa 897601 ctcgactgcg tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg 897661 ttcccgggcc ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg 897721 tgaggtaacc ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt 897781 aacaaggtag ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg 897841 gaatataaga ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga 897901 tcattccttc gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag 897961 taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg 898021 gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc 898081 tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt 898141 ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta 898201 agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat 898261 tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa 898321 agaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt 898381 caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg 898441 gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt 898501 accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg 898561 tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg 898621 gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc 898681 tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca 898741 gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg 898801 gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga 898861 aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag 898921 gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg 898981 agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta 899041 aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt 899101 tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg 899161 cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt 899221 ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga 899281 agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta 899341 aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa 899401 ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat 899461 ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg 899521 ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag 899581 tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg 899641 taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg 899701 ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc 899761 aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc 899821 tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag 899881 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 899941 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 900001 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 900061 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 900121 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg 900181 aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg 900241 cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg 900301 aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag 900361 ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg 900421 tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct 900481 tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc 900541 atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga 900601 gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt 900661 gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg 900721 ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta 900781 agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa 900841 gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact 900901 aatcgatcga gggcttaacc atatttttga atgatgtcac acctgttatc tagttttgag 900961 agaataagtt tttcaaaaaa acacttgatt ttctcaagaa tacatagtat aatgttaaat 901021 gtcactgaaa ttgtctggtg atgatggcga agaggtcaca cccgttccca tgccgaacac 901081 ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggaca 901141 tcgccaggca gacttcattc cgcagtagct cagtggtaga gctatcggct gttaaccgat 901201 cggtcgtagg ttcgaatcct acctgcggag ccattattgg agagctgtcc gagtggtcga 901261 aggagcacga ttggaaatcg tgtaggcggt caactccgtc tcaagggttc gaatcccttg 901321 ctctccgcca ctgatactta tacataatta caattgaaag tctgggcccg ttggtcaagc 901381 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcattat 901441 atgatggagg attagctcag ctgggagagc atctgcctta caagcagagg gtcggcggtt 901501 cgagcccgtc atcctccacc attatatcat cgcggggtgg agcagttcgg tagctcgtcg 901561 ggctcataac ccgaaggtcg caggttcaaa tcctgccccc gcaaccaaat tttaaaatgg 901621 tccggtagtt cagttggtta gaatgcctgc ctgtcacgca ggaggtcgcg ggttcgagtc 901681 ccgtccggac cgccatttga atacttaggc tcggtagctc agttggtaga gcaacggact 901741 gaaaatccgt gtgtcggcgg ttcgattccg tcccgagcca ccacctatgc cggtgtagct 901801 caattggtag agcaactgac ttgtaatcag taggttgggg gttcaagtcc tcttgccggc 901861 actgtttttt caaaatttaa tgtggagggg tagcgaagtg gctaaacgcg gcggactgta 901921 aatccgctcc ctcagggttc ggcagttcga atctgccccc ctccaccatt tataggggca 901981 tagtttaacg gtagaacaga ggtctccaaa acctccggtg tgggttcgat tcctactgcc 902041 cctgccaaat ttatgacatc ttgagattat ggcggttgtg gcgaagtggt taacgcacca 902101 gattgtggct ctggcactcg tgggttcgat tcccatcaat cgccccatat tatcattggg 902161 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 902221 tagcccagtc tcacttttta tatcaactgc atataatgta ttaagtccat taaaaatgcg 902281 gaagtagttc agtggtagaa caccaccttg ccaaggtggg ggtcgcgggt tcgaatcccg 902341 tcttccgctc caattacggc ggcatagcca agtggtaagg cagaggtctg caaaaccttt 902401 atccccggtt cgaatccggg tgtcgccttc ttattgccgg ggtggtggaa ttggcagaca 902461 cacaggactt aaaatcctgc ggtaggtgac taccgtgccg gttcaagtcc ggccctcggc 902521 accaatttta cttacatggt aagttgaatt ggtgtttgtg ttttatcatt ataactaatc 902581 atattaatga tctacataag tagatcattt ttttaatgct ttgatttatc ataacaagtt 902641 aagttccgag gcctattata aagcggctgt atagctagtc tttcaacact tttattttat 902701 atttccataa aaactttttt gaaatacgtt gacactttat gagatccatg atatatttat 902761 attcgtcggt tagatacgac gtaaaacttg ccggtgtggc ggaattggca gacgcgcacg 902821 actcaaaatc gtgttccttc tggagtgtcg gttcgacccc gaccaccggt atactgaaaa 902881 acccgtttct taacagaaac gggtttttat tttttattaa agaaaaggag cctcggctcc 902941 tttttatact tactcagcgt attggtctag gatctcttct agcacctctt ctagctcttc 903001 tgtatcttca agctctgatt ggctgaaacg gacgcgtaca agctgttctc cgtcattata 903061 catctcttcc aaccaccctc ggagtcctct tgctctgcgg tcgacttcga aaatgatttc 903121 caaaccgtct tcgtctaaaa ggaaaatgag ctctaattca tcaagcatct gacgataata 903181 tccggaagtc ggaacgaatt cgaattcttg aacgaacgga agacgacgct ggaagtaggg 903241 cgcttgttcg cagtctgctt cgttaagacg gaagcccagg ttttcgattg cttcaagcac 903301 attttcaatc caagggtgcg cttcaacgaa aatgcggtca tgatcggatt tatcgatacc 903361 gccttgaatg tcaaggtctg tcaccacggc aacctctact ttccctacag tgatcggcgt 903421 atctagaggc agagtgaatg tgaacggaaa ttgatgctct tcaccaggct gtatggtaaa 903481 tgaaccagtg acccggaaag aatgaattgt agcgtatttc cggtgctctt catcgtcttt 903541 tacaatgaca taccgtgtgc taagctgtaa atcgatataa cggatgtcct gagcgatttt 903601 tccgcctttg acatgtaccg ttccctgtac ttcttctcct ggaaaatatg cgtctttttc 903661 taaaattgta tctacttttg cagctccaat tccggcactt gccgcaagct tcttaaaaaa 903721 tgacatgtta gatcttcccc tttttctttt ttctcaacag atatacgtaa gaaggaggaa 903781 aaaagattcg tttgattcat acttttttcc tattattcgt ctcggcctag ggacagacta 903841 agaataatat tgaaaataaa ggagtcgatg gaagtgaata aagaaagttt ggttgcagat 903901 gaattacaca gaatgttttt ggctggtgag ctgcaaatca cagtagagga ggatataaac 903961 aatatttccg aaaggctgag aaacggcgat ctcagtttag accgattaag cggtgaagac 904021 gtgtttataa aagaaacggt aaatgaggct ttaagaagag tggagcaata aaaaagagac 904081 ggcatctcat ctttgagatc ccgtctcttt ttgtggtctt tgctgtaaga taaaagcgaa 904141 tcgatttgga attgctcacc cgagccaccc cttttctaac agaagatctg acagttcatc 904201 atggagataa acagctgtat ctaattgatc atgcaatgct cttctgatgt ggggattttc 904261 ggttgctgtt gttgcgacag tgtatttgtt aatgctggtt tttattgttg ttaacaaatc 904321 aagaatatct ttgggacaaa gactttgttc aatgggaaac cacctccttt gtttttttag 904381 cagctcctga taagaaagta tttgactttg tttcttgctt ctatacaaaa tgctataata 904441 agcaacaaat tttgttgggg ggtgtgatga tgaagcagat tattgcgatg gggggcgggg 904501 gtttttcgat ggagccggat aatttgtccc tcgatcaata tatcctcaat caatcaaaac 904561 gagagcagcc tcgtatttgt tttttgccga cggcgagcgg agattcccaa aactatattc 904621 agcggtttta tcatgcattt caaacattgg attgcgtgcc gtctcattta tctttgttta 904681 agccaccatc atcagattta gtttcttttg ttatggaaat ggacgtgatt tatgttggcg 904741 ggggaaatac gcggaattta cttgtgttat ggaaagagtg ggggctggac catattctca 904801 gggaagcatg gaagaacggt gtggttgtag ctggaataag tgccggtgcg atctgctggt 904861 ttgaagaagg ggtgacagat tcagccggac cgctgacaag tttgaaaagt ttaggttttt 904921 tgcaagggag cttttgtccc cattatgacg gggaaaagga tcggagaccg gcataccacc 904981 agctgatatc taacaagttc ttatgcagtg gctatgcagc ggatgatggg gctgctctcc 905041 atttcataaa tgatcagctg tttcagactg tgagttcaag gtcgggtgca aaggcatatc 905101 gggtgatgat ggctgaacat gaaatagctg aaatcccgtt gccggtcaaa tatttagggt 905161 gaaattggct gaatattatc tatattcctc tttttttcag attgatttta tgataagatg 905221 agtgcgaaat caatagttac tgggggtgcc cgctttcggg ctgagagaga aggcaagctt 905281 cttaaccctt tggacctgat ctggttcgta ccagcgtggg gaagtagagg aattgttttt 905341 gttattgtct tgctgggcaa taatatgttt ctttctgact gtaaccgggt tcatttatat 905401 gaatccggtt ttttgtgctg gttatgggct tgattttgtc ctttcaaacg tagaaagggg 905461 aaggaaaagt aatgcaaaac aattcagtgc agcaagccaa catttccatt atgtcaagtt 905521 tttcaggcag caagaaggta tacgtggagg gttcttcttc ggacatccaa gtgccgatga 905581 gggagattgc attgagtccg acgacgggat cgttcggcga agaggaaaac gcgcctgtgc 905641 gtgtctatga tacaagcgga ccgtatacgg accctgaagt aaccattaat attcaagaag 905701 gattaaagcc gctccgccaa aaatggatca cagagcgcgg tgacgtggaa gagtatgaag 905761 gtcgggctat aaaaccagaa gataacggtt ataaaaaagc aaaaccaaac gtaagctatc 905821 caggattaaa gcggaaaccg ctgagggcga aggcaggtca aaatgtcaca caaatgcact 905881 atgcaaaaaa ggggatcatt acacctgaga tggaatttat cgccattcgt gagcatgtgt 905941 ctcctgaatt cgtcagagac gaggtagcca gcggccgggc gattattcct tcaaacatta 906001 atcaccctga aagtgagcca atgattatcg gccggaattt tcatgtgaag attaatgcaa 906061 atatcgggaa ttcagcggtt acgtcatcca ttgaagaaga agtggaaaaa atgacgtggg 906121 ccatccgctg gggagcggat acgatgatgg atctctctac cggaaaagat attcatacga 906181 cgcgtgaatg gattatccgc aattgccccg tgcctgtggg aactgttccg atttatcagg 906241 cgcttgaaaa agtaaacggc gtagctgagg atttaacgtg ggagatttat cgtgatacgc 906301 taatcgagca ggcagagcag ggagtggatt attttacgat tcacgcgggt gttttgctta 906361 ggtatgtacc gctgactgcc aaacggacaa ctggtatcgt gtcacgcggg ggagcgatta 906421 tggcgcagtg gtgtctggct catcatcaag aaagcttttt atacacacat tttgaagaaa 906481 tatgtgagat tatgaaaatg tatgatattg ctttctctct tggggatggt ttgcgtcccg 906541 gatcaattgc tgatgccaat gacgaagcgc agtttgctga attagagacg cttggagagc 906601 tgacgcaaat tgcctggaag catgatgttc aggtgatgat tgagggtcct ggacatgttc 906661 cgatgcataa aatcaaagag aacgtcgata aacaaatgga catttgtaaa gaagcgcctt 906721 tttacacatt ggggccgttg acaacggata ttgctccggg atatgaccat attacttcag 906781 cgatcggagc ggcgatgatc ggttggtacg ggacagcaat gctttgttat gtaacgccga 906841 aggagcattt ggggctgcca aaccgtgatg atgttcgtga aggagtcatt acatataaga 906901 tcgctgcgca cgctgcggac cttgcaaaag ggcatcccgg agcgcaaatc cgggatgatg 906961 cgttatcgaa agcccgtttt gaattccgct ggcgggatca gtttaattta tctcttgatc 907021 cggagagagc ccttgaatac catgatgaaa ccctgcctgc tgaaggagca aaaaccgctc 907081 acttttgttc catgtgcggt ccgaaatttt gcagcatgag aatttcacag gatattcggg 907141 attatgcgaa gaaaaacgat ctcagtgaag cagaagccat aaataaagga ttaaaagaaa 907201 aagcaaaaga gtttgtcgat acgggaagca atttatatca ataaaaaaaa tgaagatgga 907261 gaatgctcca tcttcatttt tttagaaaaa cagagagcgt cgaagcggag gaatactctg 907321 ttcaaagcgg aaaacatttt ctggatcata tgtcgttttg acacggcgga gtcgttcaac 907381 gttttcgccg taatatgttc ttggccagtt tctgatttcg atatctggcc aatttacgta 907441 gtctcccatc gtttctttcg aaagggacgt tctcagcccc tcaatccagc ggacattttg 907501 tcttttttct ccaggggatg tccagtttgt taagtattcc tgggcgatga ttgcgtcacg 907561 ataataaaat gccgtttggt cgggagcgac ccgtccggct gccccgccga gtgcttgctg 907621 ccagacactg gcgttttgat tcggagcgtg ctctaaaaag tgttttattg ttgagatcgc 907681 acgttctgat aatggctttt caatgaaaga gccggagcgt ttcatttttt gaggctgatt 907741 gcctcccggg ctgttaaaaa aggttaccgc ttcaatgaat ggcgttgttt ttaccattcc 907801 gcttgtcgga cttcctgctt tcaataaagg ctttaacagt ttttttaact ctgtttttgg 907861 cccgacaaat tggccgaggg cttctatgcg gtttacttct ttaggccaaa actctattga 907921 tgatgtaagc cggtcatctg tatacggggc ccagttctgc cacgtgttat atacttcctc 907981 aaaatcatcc catccccatg taatagaaaa aatcgacact tgagagatgg gcactgcttt 908041 aaatgtcatg gaggtgacta tgccgaaatt gcctcctccg cctccctgag acgcccaaaa 908101 taagtctgga tgatttgaac agctgactgt aatcagatca gcgccctctt tttcgtctgc 908161 tacgatcatc tcaagctgca cgaggctgtc gcaagtaaga ccggcagccc ttgttaaaag 908221 tccaattccc cctccgagag ttaaacctgt gagccctaca ttagcaatgg tgcctgcggg 908281 aagcgtcagg ccgtattgcc agagtgtccg atagacttct cccaattcag cccccgcttc 908341 aatataggcc agctttttat cctgattcac agttattttt ttcatctcgc ttaaatcaat 908401 aacaagaccg ttatttaaaa gggaaaagtt ctcatagctg tgtctgccgc ctctaatacg 908461 gaaaggcaca cggttttcac gcgcccattt cagcgcattg agtgcatcct gtttgttttg 908521 gcaaaacaca atgatgtcag gatacctttc taagcttagg ttaatattgg ttcttgcttc 908581 gttatagtcc ggatcatccc gtgtcacgat acgtccggtc aattttgtct tttccacact 908641 cccacatctc tttctctcgt attctagttt ctctagctta tgcgtcaggg gaaaagagtg 908701 tataaggaaa aagcggggat gcaatctgat acagtgtcaa caccctcaaa aaatagttga 908761 caggtcggta ttgtatgaat taacatggtc agtacaaatt tttcaaattt atcgcgctga 908821 tcggaacacc gaaggctctt atcgtttaga taagggcctt ttttgtatga aaaagggggg 908881 attattgatg ggagtcaaaa aagaaaaggg gagaaaacga ttcaggaagc gaaaaaccta 908941 cgggaatcag attttgccgc ttgagctgct gattgaaaaa aacaaacgag agattataaa 909001 cagcgcggaa ctcatggaag aaatttatat gaagattgat gagaagcata cgcaatgtgt 909061 aactaaatat aaaaaaaccc gctgactaca acgggttttt gcatttctcc attaagaatc 909121 ttttttaatc ggcaatccaa ggccttctgc cacgcgtttt ccgtattcag gatccgcttt 909181 gtagaagtgc tcgatttggc gcagcttgat ttcttctttt tctaccggct tcatggcatt 909241 aacgatattt tcaacaaggc gggtacgttc atcttcactc attaaacgat acagatcgcc 909301 ggcttgagtg tagtgatcgt agtgatcgta gcttacgctg tcagcgatac cttgtaccgg 909361 atatgctgct tgcttatcct caggtgactc ttttggaccg ccgaagctgt taggctcgta 909421 atacacagat ccgccgccgt tatcatcaaa acgcatttgc ccatcacgct gataattgtt 909481 tactttgttg cgtgcgcggt tgattggcag cgcttgatgg tttgcaccga cacggtagcg 909541 gtgtgcatca tgataagcaa aaagtcgacc ttgaagcatt ttatccggtg aaacatcaat 909601 accaggcacg agggttccag gtgaaaatgt cgcttgttct acctctgcaa agtagttttc 909661 cggatttctg tctagaacca tgcgtccgac ctcgattaac gggtagtctt tttgagacca 909721 aacttttgtg acatcaaacg gatcgaaacg gtacgtattt gcatcttcta aaggcatgat 909781 ttgcacatat agtttccatg caggataatc accgttttcg attgcgttga aaaggtcttc 909841 tgtatggtaa tcagggtttt caccggcaat ttttgctgcc gtattgacat caaggttttt 909901 cacgccttgt tctgttttaa agtgatattt aatccatacg ccttcgcctt cggcatttgt 909961 ccatttgaat gtatggcttc cgaagccgtg catgtggcga agtgtcgcag gaattccgcg 910021 gtcagacatc aggattgtca cttggtgcag tgactctggt gaaagtgacc agaaatccca 910081 tacagccgta gggtttttca ggtgtgtttt tggatctctt ttttgtgtat ggatgaaatc 910141 agggaactta atcgcatcgc ggataaagaa tacaggcgta ttgttgccga cgatgtcgta 910201 gtttccttct tcagtataaa atttaacagc aaatccgcgc gggtcgcgaa ctgtgtcagc 910261 agagccaagt tcaccggcaa ctgttgagaa acggatgaac aacggtgtgc gtttgccgac 910321 ttcagaaagg aaagcggctt tcgtgtattt tgttacgtcg tttgtcactt caaaatatcc 910381 gtgtgcgcct gctcctttgg cgtgaacaac acgttcagga acacgttctc ggttgaaatg 910441 ggccaatttt tcgagtaaat gtacatcttg aattaaagtt ggtccgcgag aaccggcagt 910501 cattgagttt tgattatctc caaccggagc gccccagcta gttgtcagtt tatttgaact 910561 catgttatca cctcttggaa tttataagaa cataatatca tctctaagta aaaagtcaat 910621 attattttat aattattata aaatagttat ctctattaat cgatatatag tatcgaaatt 910681 gttgaaaaac cttgttgtaa cagcttttta tgacacttaa taatttttgg agaaataatt 910741 tttccttctc tatttgcgaa acaagcagag taagtgataa acaaggatat caaaaatcgt 910801 atttaaaaaa gagttgacat atcggaataa tttgaattaa catgttattc aaacaaaaaa 910861 acaattgggc agctgatcgg accgccgaag gctctcatct ctacaagaac agagatgggg 910921 gcctttttgt tttttttgaa ggcggggttg gcagaaagag agggataaaa gtggctgtga 910981 ccatcagcat caaagaaaag gcatttgttc aagaaggccg caaaaacacg gtcttagaaa 911041 acatagaatt atcaatcgca ccaggcgaat ttctaacgct tatcggaccg agcgggtgcg 911101 gaaaaagcac cctgttaaag attattgcag ggcttgattc tgaatatgac gggagtgtgg 911161 aaattaacgg ccgcagcgta acagctccgg gtattcagca aggatttatt tttcaggaac 911221 accgcctctt tccttggctg actgttgagc agaatattgc agccgacttg aatttgaagg 911281 acccaaaagt caaacaaaag gtggatgaac tgatcgagat tgtcagattg aaaggatcgg 911341 aaaaagcata tccgcgcgag ctgtcaggcg gcatgtcaca aagagtagcc atcgcccggg 911401 ccctgctgcg ggagcctgag gtgctgcttt tagatgaacc gtttggtgca ctcgacgctt 911461 ttacaagaaa acacctgcag gacgtgctgc tggatatatg gaggaagaaa aaaacaacga 911521 tgattctcgt gactcatgat atagatgaat ctgtttattt aggaaatgag cttgcgatcc 911581 ttaaggccaa accggggaaa atccataagc tgatgcccat tcacctggcg tatccgcgaa 911641 accggacgac tccggatttc caagcgatca gacagagagt gctgtcggaa ttcgagaaaa 911701 cagaagattt ggagtacgca gaaggatcag ggatatagaa agggcggaag cggaaatgaa 911761 aaaaggactc attgtattgg ttgccgttat ttttctgctc gcaggctgtg gagcaaatgg 911821 agccagcggt gaccacaaac aattgaagga aattcgtatt ggtattcagc aaagcttaag 911881 cccccttttg attgcaaaag aaaaaggctg gttcgaagat gcatttgaaa aagaaggcat 911941 caaagtgaaa tgggtggagt ttcaaagcgg tccgccccaa tttgaaggcc ttgcggcaga 912001 caaacttgat ttttctcaag tcggtaattc gcctgtgatc gctggacagg cggcaggcat 912061 tgactttaaa gaaatcggtt tgtctcagga cggcttgaaa gcaaacggca tccttgtcaa 912121 tcaaaacagc ggcattcaag acgttaaggg cttaaagggg aagaaaattg cagtcgccaa 912181 aggcagcagc gggtttgatt ttttgtataa agcgcttgat caagtggggt tgtcagctaa 912241 cgatgtgaca attattcagc ttcagcctga tgaagcagct tccgcatttg aaaacggatc 912301 tgttgatgcc tggtccattt gggagccgta cttgtcctta gaaacaatga aacacggagc 912361 aaaaatcctt gtgaacggag aaagcacaga tttatattca ccgggtttta ctttagtaag 912421 aacaaagttt tcagaagagc atccagacga agtggtccgt tttctgaagg tgtttaataa 912481 agccgttgta tggcaaaagg aacatctgga tgaagcagcg gacttatatt ctgacattaa 912541 agatctcgat aaaaaggtcg tcgaaaatgt gctgaaaaat actgagccac ttaatgagat 912601 catcagtgac gacattgtga aagcacagca ggaaacagca gattttcaat ttcgaacaaa 912661 ggcgatagat aagaagattg atgtgaagga tgttgtcgat aacactttta tcaaaaaagc 912721 attagaggag cattcctcag gaggtgatca atgatgaaag cagaggctgc gggctcgctg 912781 cccaaaacga atgcggaagc ggtgcgaaaa aagcccggaa ggaagagata cggctggatg 912841 aaggggcttt tactgcccgc tgtcatcatt gccatctggc aggtcatcgg cgggctgggg 912901 gttgtgtccg ctacagtgct gcctacacct gttacgattg ttctgacctt taaggagctt 912961 attttgtccg gcgaactgtt cggccatctg caaatcagca tttatcgggc ggcacttggt 913021 tttttgcttg gcgcggggct tggattgatg atcgggattt tggccggatt ttccaaacgg 913081 acggagctgt atcttgatcc gtcgttgcaa atgcttagaa ccgtacctca tctggccgtc 913141 acgccgctgt ttattttatg gttcggattt gacgaagtat ctaaaatttt gctgattgcg 913201 ctcggtgcct tctttcctgt ctatatcaat acgtttaacg gcatccgcgg ggttgacgcg 913261 aagctgtttg aagtcgcccg ggtgcttgaa tttaaatggc atcagcagat atccaaagtg 913321 atattgccgg cagccctgcc caatatattg ctaggcattc gcttatcgct cggcattgca 913381 tggctcgggc tcgttgtggc agagctgatg ggctcaagct cgggagtcgg ctatatgatc 913441 atggatgcga gacagttttc acaaacgaat aaagtctttg cagggattat catttttgca 913501 gtggttggaa agctgacgga ttccttcgtc aggctgcttg aacgaaagct gttaaagtgg 913561 agaaacagct acgaaggata aaagatataa aggggagatg aatatggaaa ttctttggtt 913621 tataccgact catggagacg cgagatattt aggatctgaa agtgatggac ggactgcgga 913681 tcatctttac tttaaacaag tcgcgcaggc ggcagacagg ctgggatata caggagttct 913741 tctgccaacg ggaagatcgt gcgaggaccc gtggcttaca gcgtcggcac tggcaggaga 913801 aacaaaggac ttaaagtttt tagtcgcggt aagacctggt ttaatgcagc cttctctggc 913861 agccagaatg acatccaccc tagaccgcat ttcagacggc cggctgctga tcaacgttgt 913921 ggcagggggc gatccgtatg agctggcagg cgatggcctg tttatcagcc atgatgagcg 913981 ctacgaggca acagacgaat ttttaaccgt ttggcggaga cttttgcagg gagaaacggt 914041 ttcctatgaa ggaaagcata taaaagtgga aaacagcaat ctgcttttcc cgccgcagca 914101 agagccgcat ccgcccatct atttcggtgg ttcgtcacag gctggaattg aagctgccgc 914161 aaagcataca gacgtgtact tgacatgggg tgagccgcct gaacaagtaa aagaaaagat 914221 agaaagagtc aaaaagcaag cggcaaaaga agggagatcc gttcgatttg gcattaggct 914281 gcatgtcatt gcccgtgaaa ctgaacaaga ggcatgggaa gcggcagagc gcttgatcag 914341 ccacttggat gatgacacca ttgccaaagc gcaggcagct ttgagccgtt acgactcttc 914401 aggccagcag cggatggccg tccttcatca aggcgatcgg acgaagcttg aaatcagccc 914461 gaatctgtgg gcggggatcg gcctggtcag aggaggggca ggaacagctc ttgtcggtga 914521 tccgcagacg attgccgacc ggatagcgga gtaccaggca ctcggcatag aatcgtttat 914581 attctccggc tatccgcatt tagaagaagc gtattatttt gcagagcttg tatttccgct 914641 tttgccgttt gaaaatgatc ggacgagaaa gcttcagaac aaaaggggag aagcggtagg 914701 aaacacttat tttgtcaaag agaaaaatgc atgagtttaa ctaaaataca gccccccgaa 914761 catggtatga tattcaaaaa aagggggctt tttttctgaa aacattgaga agcgcggcag 914821 tcatttgcct catagctatg ctgtcagcat gcggacattc aaaacagatg gaaatcaaag 914881 cggcggacat atcagatctt gaaaaaaaca gaatggatgt cgcagcttca caggcattca 914941 ctgccgaagc cgtcaatatc ggtgaaggta tttcttcagc tgacatgtac atcgaacatt 915001 atcaaaaggg aaagcttgtt gagaggtttg gaccggttcg tgcagattat tcagaggaaa 915061 aaactgatac catacaattt gtttattttg agaatgaaga gggggaagga aagaataaac 915121 ataccaccat tcattttggc attgtggata aacagggaac tatagcggct gattcatcgg 915181 tgaaacgcga cgatagcaca acacaggaaa tgactcagaa tatttcatcg ccggaaccga 915241 ttactttcga gaagcctgct ttgatcggca gcagtattag agggactgac gagacaatgc 915301 acacctctga acataaaaaa gagctcatta agcatcaaga tgcgttactg tattatgtgg 915361 aattgcatca ttagaatggg cggcttcagg ccgtctgttt tacaaagcgg tatgcttgct 915421 tttttgaatg gtgaatgata cattttaaat cgtaacaatt tcgatttaaa gggaggctat 915481 gtgacttggc taaaaaatca aaagtggcaa aagagttaaa acgccaacag cttgttgagc 915541 aatacgctgg tattagacgc gagttgaagg aaaaaggaga ttacgaggca ctcagcaagc 915601 tgccaagaga ttcagcaccg ggaaggcttc acaaccgctg catggtaacg gggcgcccga 915661 gagcatatat gaggaagttt aaaatgtcca gaatcgcttt cagggagctg gcccataaag 915721 gccagattcc cggtgtgaaa aaagcaagct ggtaagaaaa aactccggcc gattacagcg 915781 cgccggagtt tttttcgttt ttcttgaaag agatgacgta ggaaaggtgc tggatgatca 915841 tgatgataaa cacaataata atagggaaaa acggaatgcg cgattgaaat agcggataaa 915901 aaatgagaag aaccgctgcg gcaggcagcg agaagtagac agcgatatat gacgcgcgac 915961 atgcttttgc cgtcatcatc tgctctcttt catcctgctc ttcaaactca tcaggcagaa 916021 gtagctgctt tctggcaggg cggctttttt tctgtaagta caaataaacc gcagacgccg 916081 caacaaacag aataaaggga gtgaggttta aatcaaatac catcccgccg ctctttgtgc 916141 cgaaaaaaga tgctatgcct tctgaggctt caaagtatga aatcagcgcc cagcatgcaa 916201 ggccaaataa aacaaggtga aaagctgctt ttgttttcat gctcatctta gttttcctcc 916261 tctaaccaaa agacatcctc cattttcatg gagaaggctt tgcagatttt cagtgctaac 916321 agcagtgagg gaacataatc gcctttttca atcgctgcca cagtctgtct tgtgacgccg 916381 accgtttctc cgagtttttc ctgagaatag ccgaagcgtg ccctcagctc ttttacttta 916441 tttttcatca tgacgtctgt ccccttcaca atctcgattg attatattgt atagtatact 916501 taacattatg taaatggaac ttaacaactt tacaaaaaga taactttttt tcgacaaaat 916561 ttttatattc ccttgacgaa aaataaataa acatgtaata taaaaaaagt cagagcggta 916621 ctgttgctga caatcacaaa tgcgggtgta gtttagtggt aaaacctcag ccttccaagc 916681 tgatgtcgtg agttcgattc tcatcacccg ctccatacat acgttattaa cgcagtgttt 916741 cgtttctcag ataaacgaag tattgcgttt ttttatgtga aaaagaacac ggtattcgtg 916801 ttcttttacg taagccaatg tactgtatgg gtgccgccgt gaatttgttc aaacattttc 916861 gttaatgatg ataagaggtt aacagcgctg cttttctcaa tcgatggcgg gaaaaaaatg 916921 atttgcagca tattcttagt ctcgtttgaa acgggatagt ggttgacgct gtttttgaaa 916981 tcgccaaaaa tgccgttttc atcagagaaa agcagtatgt tttctttttc tcccaatgag 917041 atccggaccg gctcatgaag ctttccggca tcataaatca taataggcag agaatatttt 917101 aatgcgaaaa aatcgattgt gtcatgggcc gagtctttac tttccatgaa ttgttccttg 917161 gatatcggga ccagcatgtc ctccattggg gttgtttctc cctcaaatga agggttaagc 917221 tgtttaaaga gtttctgcca ttccttgacg aaggattcat cggatatacc gccgtccgca 917281 tagtcgaaaa acaaggattc ttgaaacagg cggagtctgc ctttcagcat ttgcggtgag 917341 gagccgactt cgatattctc ataaatgaca gcagctgcat gtaagccggc cgcacgttca 917401 gtaataacag aatcaagttt gatattcact agcattcact ccagttacgt gatatcaacc 917461 tattataaac gctgtgtcgt tttatcacaa agaaaggagg ctgtgcaaaa catgaacgtt 917521 tatcagctca aagaagaatt aattgaatac gcgaaaagca ttggcgtaga caagattggt 917581 tttacgaccg ctgatacttt tgacagttta aaagaccgtt tgattcttca agaatcactc 917641 ggctatctct ccggctttga agagccagat atcgaaaaaa gggtgacgcc gaagcttctt 917701 ttgccgaaag cgaaatcaat agtggcaatt gctctcgcat atccttccag aatgaaggat 917761 gcgccgagaa gcacgagaac tgagcgcagg ggcatttttt gcagagcttc ctggggaaaa 917821 gactatcatg atgtgctgag ggaaaagctt gatctgctgg aggattttct aaaaagcaag 917881 catgaggata tcagaacgaa gtcaatggtt gatacaggtg aattgtctga tcgcgccgtt 917941 gcggaacgtg ccggaatcgg attcagtgcg aaaaactgta tgatcacaac acccgagtat 918001 ggctcttatg tgtatttggc ggaaatgatc acaaatatcc cttttgagcc tgatgtgccg 918061 attgaagata tgtgcgggtc ctgcacgaaa tgcttggacg cctgcccaac gggagcactg 918121 gttaatcccg ggcagcttaa tgcgcagcgc tgcatctctt ttctgaccca gacaaaagga 918181 tttttgcctg atgaattccg gacaaaaatc ggaaaccgcc tgtacgggtg cgatacgtgc 918241 caaacggtat gccctctcaa taaagggaag gattttcatc ttcatccgga aatggagcct 918301 gatcctgaga ttgccaaacc gttattgaag ccgcttttgg ccatcagcaa tcgggaattt 918361 aaggagaaat tcgggcatgt ctcaggttct tggcgcggaa aaaaaccgat tcagcgaaac 918421 gccattctcg cgcttgccca ttttaaggat gcttccgcac tgcctgaatt gacggaactg 918481 atgcacaagg atccgcgtcc tgtcatcagg gggacagccg catgggcaat cggaaaaatc 918541 ggagaccccg cctacgcgga agagcttgaa aaagcgctgg aaaaagagaa ggatgaagag 918601 gcaaagctgg aaattgaaaa aggaattgag ttgctaaaag cttcaggcat gactaaacaa 918661 ggcctgtcct gacatacgta tagagcagaa ggaaaaaaca cttgagatca tccaagtgtt 918721 ttttctctat aaaaaagtat ggcgggtggg gtgagcttga agtacatttt agaacaatta 918781 gcggaggagc ggctgggctt tctggttaac gggcatgcta tgagacagga gtctcaagtc 918841 ggagacctta aagtcatgga gcgtaagaaa aagcttctgg aaaaacgtaa agttgacatc 918901 ataaaagcga aagcaaaggc cgtgattaat catgtgcggg ttgaggatga cggaacgacc 918961 tgcctttcgt ataccatcca ttacgaatac gtgtgtaagg aacaagatga cagcttgtat 919021 atagaagagc acatagagga gcgaatggct ttcctgtatg atcacatttt gattagtgat 919081 caggaaattg cgaaaaagcc ggctggattt catgaaggga ccagtattat tgactattct 919141 gaagctgaag aggaaagaga agcgtttggc agggcttttc aatacgatcg tctcggcgct 919201 gtccaatatg ccgagaaatt ttggaacaag cgcaatcctg cttataaaaa tttcagcgat 919261 aactgtacaa attttatttc tcagtgtctt catgcaggag gcgcgccgat gcgcggtcat 919321 ccgaacaggg gatcaggctg gtggatgaaa caaagctcat ggagctacag ctggacggtg 919381 gctcactcta tgaaaatgta tttgtcgaat tcaaaggccg gactgcgtgc ggtgcgggtg 919441 aaatcagcgg aagaactgat gccgggcgat gtgatttgct atgacttcga aggagacggc 919501 cggtttaatc atacaacgat tgtcgtggca aaggacaaag gcaatatgcc gcttgtcaac 919561 gcccagactt atgacagcag gatgaggtat tggtcatatg aggattctac ggcatacacg 919621 ccgtcaatac gatatgcctt ttttcatatc gttgatgata cgacaaaaga gtaattaatg 919681 ttataatgat gggcggataa gaaaaacaga ggtgaacatt gtggcattac atgtcgtttt 919741 atatcaacca gaaattcccg ctaacacagg gaatattgca cgtacttgtg cagcaaccaa 919801 tacaacgcta cacctgattc gtccgctcgg cttttcaacg gatgataaaa tgctgaagcg 919861 tgccggactc gattattggg agtttgttaa cgttgtgtat catgattcgt tagaagaatt 919921 gtttgaggca tataaaaaag gcaagttttt ctttattaca aaatttggcc agcagcctca 919981 tacatcattt gattacactg atcttgacga ggattatttc ttcgtgttcg gaagagaaac 920041 aagcggtttg ccaaaggatt taattcaaaa taatatggac cgctgcctgc gtcttccgat 920101 gacagagcat gtcagatcgt taaatctgtc caatactgcc gcgattcttg tttatgaagc 920161 gctgcgccag caaaattacc gtgatttaaa atagtgaaaa acccgctcat cgatgatggg 920221 cgggtttttt tgcggatgtt gaaatgcttt gtttcgtttt tgggcttaac aacgtaacag 920281 tgttatgtta caatgtaccc atcaaaggag ctggacttat ggaagaacaa ttaatctcta 920341 aaaaagaatt acttgaaaga acatcgattt catacggtca gctgtatcga tggaagcgga 920401 aaaacttaat acctgaggaa tggtttattc gtaaatccac atttacaggg caagagacgt 920461 tttttccgag agaggagatt ttaaaacgta tatcaatgat tcaaaagatg aaagaaaatt 920521 tgtctttgga tgaaatgagg gaaatgctgt cgccgaaaat gaaggatgtc agcatgaccg 920581 ctgatgaatt gcttcataaa ggtttggttt caaggcctgc tcttgaagcc tattcagaag 920641 acggaggaag tccggttttt tcatccagcg atttgctttc gctgtttgtg cttgagggcc 920701 tgctgcagtc tggaaatgtc agccttgcag aagcaaaaat ggctgcagag gtattaaaga 920761 agcatgatac tgaagagatt gaaaaacaga cggagctgat tgtgctccgc aagctcggtg 920821 tcacaacttg ttttatagcg gctgcggcgg acagcatttt gtttgaatca tccgtaaagg 920881 ttgtggaacg ggtagattta ttaaaagctt cagaggaatt aaaaacaaca tttatgcagg 920941 agggccatca atggatgtag tggaaaagct ggtgataaat ggatcaggaa gttctaaggg 921001 aggaacattt caatcagttg agattaatgg cagcgggaca gtggccgggg acgtggagtg 921061 tgacactttt tcttttaatg gaaacggaaa agcggacggc agcgtcaaag cgaaagcggt 921121 aactatcagc ggttcaggaa agatacatgg agacgttgaa gcagaatcta tccggatgaa 921181 tggcactggt tttattcaag gagaggtatc tgcaaaacaa ttgaaaatcg ctggatcatc 921241 aacatttggc ggcactgtca aggctgatgg aattgacatt agcggaaaag ctgtcatgga 921301 agcagattgt gaaacagaaa cctttcaatc agaagggaaa tgcaaaatca gcgggctttt 921361 aaatgcagac caggtgatca ttaagctttc tgcaggggaa agctatgcgc gggagatcgg 921421 ctgccgccat cttcaagtga cctgcagaaa aggaatgctg acattgctca gattgatgcc 921481 gcagcctgtt ctaacagcag agctgatcga aggtgacgtg attgaattga caaatacaaa 921541 ggcgaaaacc gtgcgcggta ataaagtgat catcggcccg gattgccaga ttgaaaccgt 921601 cgaatacagc ggggactata cctgtgatcc aagcgcgtcg gttgaaacat ccacaaagtt 921661 gtaaggagga tcgtaatgga gacaacaaaa ctgggaaatt taaaattata tggcgctggg 921721 catgccgcag gaggcgcgta tcacaatgtc agcatcaaag gagaaggtat agttggagaa 921781 gggctgtctg ctgtaggctg ccgcatatac ggaacgggcc tttttctcgg aaaagcagag 921841 actgagcggc tgcgtgtgct cggagaaagt gaatgtaaag gcgatctgac agccggcaaa 921901 atcaatatat atgggacaat gaaagtcagc ggctcacttc aatttgatcg attcaatctg 921961 aaaggccaga ctgaaattgg cgggaatatg actggagaat cctgcgatgt gaaagggaag 922021 cttagcgtaa taggtgattg tgaaacagaa atgttccatg tcacaggctg tgttgatgta 922081 tcggggttat taaattcggg tgagatcaag ctgggattga gccatgatat aagccatgtg 922141 caggaaatcg gcggaacaac aattacagtg aaaagacgcg cgagtttttt tagccggaag 922201 aaagggaagc tgatcgccga tgtcatagaa ggagatcggg tttatttgga gaataccgaa 922261 gcggcagttg tcaggggaaa agaagtgatc atcgggccgg gatgcagcat cggaacgatt 922321 gagtacgaat acaaatgtga atgcgatccg cattcacaga ttaaagaaaa aacaaaactg 922381 taaaacattg ttctgttata caaaaagggt gctctttcag gagcaccctt ttttattctt 922441 ttccaggctt gctttcgtat cctgcggtaa aaattgatac taaaaaagtg acaatgacac 922501 ccatcatgat gattgttttc accgtctctc cccctcttca atttttccgt gctgtccgag 922561 tctggatgat tctgtatttt tctttattat gaacggtcgc agtctgcctt gtcaacgatg 922621 tatgagtatc tttattttta agaaaccaaa gcatgtatca cgagatggcg gcatagattg 922681 tatcaaagta ccttatttgc atagtgtatc aaacatgata gaggaggtcc ttatggatat 922741 attaaagaaa attgaaaagt acagagagga agagcagcgg ctgaaatggg aaggaacttt 922801 cgccgattat ttggagatta ttaaagaaaa tccgatggtc gcgcaatctg ctcattctcg 922861 agtttttaat atgataaaag acagcgggat agaggagatt gacggacgca agaagtacag 922921 tttttttgac cgcgagctgt tcgggcttga agaatctctg gagcgtcttg tggaagagta 922981 ttttcatccg gctgccaaac gtctagatgt cagaaagcgg attctattgc tgatggggcc 923041 tgtgagcggc ggtaaatcca cgctggtcac aatgcttaaa aaaggtctcg aagcgtacac 923101 gctgacagat aatggcgctg tatatgcgat taaaggctgc ccgatgcacg aggaccctct 923161 acatttaatc ccccatcatt tacgcgatga cttttacaga gaatacggca ttagaataga 923221 aggaagtctt tctcctttaa atgtcatgag gctggaggaa gagtacggag gaagaattga 923281 ggatgtgaag gtggagcgca tcttcttttc agaagataag cgtacgggaa ttggaacatt 923341 cagtccctct gatccgaaat ctcaggatat tgccgatttg acggggagta ttgatttctc 923401 aacaatcgcc gagtacggtt cagaatcaga tccgcgcgct tatcgatttg acggagagct 923461 gaataaagcg aaccgcggga tgatggagtt tcaggagatg ctgaaatgtg atgagaaatt 923521 tctctggcat ttgctttcct tgacacagga agggaatttt aaagctgggc ggtttgcgtt 923581 aatttctgct gatgagctga tcgtggctca cacgaatgaa acggagtatc gctcatttat 923641 ttctaataag aagaatgaag ccctgcactc aagaatcatc gtgatgccgg ttccttataa 923701 tttaaaagtg tctgaggaag agagaattta tgaaaaaatg attgcagaaa gcgatgtggc 923761 ggatgttcat attgccccgc atacgttgaa ggtcgccgcg atgttctcaa tccttacccg 923821 gttaaaagag ccgaagcggt cggatattga tctggtcaag aaaatgagac tgtatgatgg 923881 ggaaagtgtg gaaggatata actctgtcga cgttgaggat atgaaaaaag aatataatga 923941 tgaaggcatg agcggaattg atccgcggta cgtgatcaac cggatttctt caacgattat 924001 cagaaaaaat atggaatcga ttaattctct cgatgtcctt cgctccttaa aagaaggtct 924061 tgatcagcac ccatcaattt caagcgagga cagggagcgg tatttgaatt ttatctctgc 924121 cgcccgcaag gaatatgacg atattgcgaa aaaggaagtt caaaaagcgt ttgtttattc 924181 atatgaagaa tcagcaaaaa cacttatgga caattacctc gataacgtag aggcctattg 924241 caataaaaac aagcttcgtg atcctttgac aggagaggaa atgaaccctg acgaaaagct 924301 gatgagatcc atcgaagagc agatcggcat ttcggaaaac gccaaaaaag cgttccgcga 924361 agaaatttta atccgcatct cggcctatgc gagaaaaggc aagcggtttg attacaattc 924421 ccatgaaaga ctgcgtgaag ctattcagaa aaagctgttt gctgatctga aggatgtcgt 924481 taaaattacg acctcaacaa aaacgccgga tgagcagcag ctgaaaaagg taaatgaagt 924541 cgtggcccgt ttaattgatg agcacggcta caactcgacg agcgccaatg agctgctgaa 924601 atatgtcggc agcctgctga accgataagc aacgtgaccc gtccgaatag ggcgggttat 924661 tttgtcccat tttctaaata gtttgtcaat taaacgtgca tatgtgcata tgatgaatat 924721 aaatcttttc aaaagacttg tttcataatc tggcacaagc cggaatacgt atgtatcacg 924781 accacaaatg gttaaggagg ggaattcatg tcccaaaatg acagcggcca ttttttgatt 924841 tctgaggaaa actggtccct ccatcgcaaa ggcttcgatg accagcagcg ccaccagaaa 924901 aaagtgcagg aagcgatcaa aaacaatctt ccggacctcg taactgagga aagcattatt 924961 atgtctaatg gaaaagatgt agtgaagatc ccaatccgtt cacttgatga gtataaaatc 925021 cgttataact atgataaaaa taaacatgta gggcaaggag acggcgagag ccaggttgga 925081 gatgttgtgg cccgggatgg atcagacaaa aaacaagggc ctggaaaagg gcagggtgcc 925141 ggtgatcagg caggcgagga ttattatgaa gcggaagttt cattaatgga tttagaagaa 925201 gcgcttttta aagaattaga gcttccgaat ctccagcaaa aagagcggga caatatcatt 925261 catacagata tcgagtttaa tgatatccgt aaaacagggt taaccggtaa tattgataag 925321 aaaagaacga tgatgtcagc ctttaaacga aacgcaatgt caggaaaacc gtcgttctac 925381 ccaatttatc cggaggacct gaaatataag acgtggaatg acatcacaaa gcccgaatca 925441 aaagccgtcg ttttagccat gatggataca agcggcagta tgggggtttg ggaaaaatac 925501 atggccagaa gcttcttttt ctggatgacc cgttttttgc ggacaaaata cgagactgtg 925561 gaaattgaat ttattgccca tcatacagaa gcaagagtgg tctcggagga ggattttttc 925621 tcaaagggag aaagcggcgg aacaatttgt tcttccgtat atcggaagtc gcttgagctt 925681 attgatgaaa agtacaatcc cgcccgctat aacatttacc cgtttcattt ttctgacggt 925741 gacaacctga catctgataa cgcgcgctgt gtgaagctgg tcaatgatat tatgaagaag 925801 gccaatctgt tttgctacgg cgaggtcaat cagtacaaca ggcattcaac gttaatgtct 925861 gcatataaaa atgtaaaaga tgagaaattt aagtactata ttttaaaaca gaaatctgat 925921 gtttttcagg ctctaaagaa ctttttcaga aatgaagagt ctggtgtaag ccatcaattt 925981 tcgtaatgaa aagcccattt cagggctttt ttttatttaa taaaagcaag aaaacgcttg 926041 cgaaaaaaat acgggagaaa aagaaatttt tcctttgaca aatcttcttt catttattaa 926101 tattttatct tgtgaactat tattgaggaa tgaggtgaaa aggagttgac tgaatcagaa 926161 cgtgctttgc tcacttttga acagctcttc gatacgtctc gggcgatata taaaaaacag 926221 aagaagatat tggagattgt gcttgagcct tttgatatta cagtccttca atatttgctg 926281 atgtttaaaa ttcatcaaag cggaagcacc ccgctaagca agctggcaat gtcgcttgat 926341 cttaagcctg cttctgtgac gcggatgaca gatattctgt ataagcgcca attgatgaat 926401 cgatatgaca gtccggatga ccgccgtatc gtcatgattc agttaaccga agagggggaa 926461 gaactgatag aaaaagccgc tgtgcaatat gcaaaaatgg gtgctggctt gtaccaaaag 926521 cttgatacct cccagctgca gtatttgcgc aaactagccg gaagtttaac gaagcttgct 926581 gaaggctgtt cagaaaaaag cggtaattaa aaacttctca catattttca ccagctttcc 926641 gcaaaatgat agaggatgaa acgaaaggag aaaacaaaat gaacagagga cgtttaattc 926701 tgaccaacat tatcggtttg attgttgttc ttgcaattat agctggaggt gcttactact 926761 attatcaaag cacaaactac gtaaaaacag atgaagcaaa agtagcgggc gatatggctg 926821 ctattactgc tccagcagca ggtaaagtat ctgactggga tctggacgaa ggaaaaacag 926881 tgaaaaaagg cgacacagtt gcaaaaatca aaggtgaaca aactgttgac gtaaaatcca 926941 ttatggatgg cacaattgtg aaaaacgaag tgaaaaacgg acaaaccgta caagctggta 927001 caacaattgc acaaacgatt gacatggaca acctatacat cacagcaaat attaaagaaa 927061 cagatattgc ggatattgaa gtaggaaata gtgtagacgt agtagttgac ggagaccctg 927121 atactacatt tgacggtact gtagaagaaa ttggttatgc gactaactca acttttgata 927181 tgcttccttc tacaaattca agcggaaact acacaaaagt aacacaaaaa gttcctgtga 927241 aaatttcaat caaaaaccca tctgataagg tgcttcctgg aatgaatgca tctgttaaaa 927301 tttctgagta aaacagatca gtcatcaaac catgaaagga ggttgtctta gatggctaca 927361 ggcaaagaaa aaaatgcaaa aaaccctatg tcattgctga ttgtgctaat ggcgggttta 927421 tttttggcaa ttctaaacca aacactgctt aatgttgcaa tgccgcactt aatgactgaa 927481 tttggcgtaa gtgcaacgac gattcagtgg ctgacaacag gttacatgct tgttaacggt 927541 gtattgattc cgttatctgc tttcctgatt acacgatttg gccagcggag tctctttctc 927601 gtcgcgatgt tttgttttac gctcggtacg ttagtctgcg gtatcgcacc taacttctct 927661 acaatgctga tcggccgttt gattcaggcc gtgggcggag gtatcttgca gccgctcgtt 927721 atgacaacca ttctgttaat tttcccgcct gaaagcaggg ggaaaggaat ggggattttc 927781 gggctagcga tgatgtttgc tccagcggtc ggcccgactc tttccgggtg gattattgag 927841 cattatacat ggcgcattat gttttacgga cttgtgccga tcggcgcaat tgttatcatt 927901 gtggctttct tcatctttaa aaatatggtg gagccgcaaa aaatcaaact cgatactctt 927961 ggcgcaatcc tctcgattgt cggattcgcc tccttattat acggagtcag tgaagccgga 928021 tctgacggct ggaccgaccc gattgtattg tctacagtta ttatcggagc cattgcaatt 928081 gttgcttttg ttgttcagca attgcgtcat gatgatccga tgcttgattt cagagtgttt 928141 aaatatgaca ttttctcact ctcgagtgtc attaatatca ttattacagt ggcactttac 928201 actggtatgt tccttttacc gatttatctg caaaacctgg tcggctttac ggcgcttcaa 928261 tccggtctgc ttctgcttcc gggtgcgatc gttatgctga ttatgtcacc gatctcaggt 928321 attttgttcg ataaattcgg accgagaccg cttgcgatta tcgggcttct cgtgacagtg 928381 gtaacaacgt atcaatacac gcaattgaca attgatacac catatacaca catcatgctg 928441 atctattcaa ttcgtgcatt tggtatgtct ctcttaatga tgccagtcat gacagccggg 928501 atgaaccagc ttcctgcccg tctgaacagc cacggaacgg cgatgagtaa cacgcttcgc 928561 caaatcagcg gatcaatcgg aacaagttta attacgacga tttatacaaa ccggacgaca 928621 ttccattatt cacaaattgc agataaaaca agcacggcgg acccgaactt cctccatgcg 928681 ttccaaaatg cagtttcgaa tttaatggtg aatatgaatg tgtcttatga tacggcgaaa 928741 acatatgtgt actcacatat ttataaacac gcatcactcg attccaatgt catggggata 928801 aatgatgcct ttatgtgggc aaccttattc tgtgtagcag gtttgatttt aagtatcttc 928861 ctgcgtgacg tcagaaaaga taaattgcgt aagaagaaaa aagaggagct ttcattactt 928921 cctgctccaa aagaagctaa ggaatcttaa tctgtacagg gaggtttcct gaatgaaaat 928981 ttatgtagtg tatgatagtg aaggcgaaca tactaaagtg cttgcagaag cgattgctga 929041 aggcgcgaga gaaaacgacg cggctgaagt gttcatcgac catgtagatc aggctgatat 929101 ccgcaagctt aaagatatgg atgcgattat ttggggatgc ccagggcatt tcggaacaat 929161 cagctccggt cttaaaactt ggatcgacag acttggctac ttgtgggctg aaggcgagct 929221 gatcaacaaa gtcggtgctg tcttctgcac aacggcaaca acacacggcg gcttggaaat 929281 gacaatgcac aatttaatca cgccgatgtt ccaccaaggc atgattgttg tcggactgcc 929341 tggcaacgtg cctgaaaacg cactttatgg ctcttattac ggagcaggtg tcacttgtcc 929401 ggtagacagt gatgagttaa tgtctgagga aggtattcag cttggacgcg cgttgggaag 929461 acgtgtcagc caagtcacag gaaacctaac agcaggacag taaggagagg ttgaaatggc 929521 cattattata gcaataattg ctgctgtcat tgtcattgcg gcccttatta catttaacgt 929581 ccgcaacgcc tcacctggac ctgagaagca agaagcaacc gatagaatcg cacctccaga 929641 agaggaaaaa aacgaagcgc attaccctgc tgaagcaagg gctgccgagc atacgccatc 929701 cgttgtcaaa aacgattctc caaaagagaa gcgtgacaca atgggtgatg atatttacag 929761 gcaggcgctg caaaagttta agcattctga tgaagttcat gcagaagaag aggtcactga 929821 ggaaagtgac aaaatgcagg accgcagcta tcgtgatgcg ctgctctcta tgaaaaataa 929881 gaaaaagtaa tgaaaaaggc aaatccgttt actcatgcgg gtttgccttt tttgctgttt 929941 ccatcaatta tgtttttatc aaataaatcc atggaatatg ttgtattcca ccttgatcta 930001 gtgtactatg ttactcatac accgaggatt ttttccggga ggtaaagaca tgaattcttt 930061 tttaggttta ttaaagaaag atatcaagct ttcaagaatg tggctgctag tatggatatg 930121 cggaatcatt ttcttattgg gaacaggcca tattatagct tctcgcacga aagaacctct 930181 agtcattttt ggtttttttg ttgcagttgc tttttttctg cttttcttat ctcctgtttt 930241 tgttttttat caccttcgca aggaagggaa atcacagctt tggctgtaca atccaaatgg 930301 cggcttatgg ctgttttctt ctaaattggc agcatctttg ctctatcaat ttgtgattca 930361 gttggcatta acagcctatg gcatatggat gtatcatatg ctctctgtaa aaaatctgct 930421 ggagcatcaa gttgatataa cgagtacagt ggctttgctg aatatgtatg ggcttatttc 930481 ttcgttagat atgtcagtaa cagtcattgt gttttggact gtttttcact ctctcagaaa 930541 ttggcgcgga atgcggtggg ctgcgatggt tctgttggtc gcaatgtggt tattcttcga 930601 tgaatacatc ataagccctt tggttgaatc tcaaaagcat ttctggcctg taacagtcta 930661 ttgcaatttt gatttccact tccacaatgt ttggagattg gaactaaaac ctatccatct 930721 gtctgtgcta gggtttccta ttgctatagt catcacattc ttgctgctca tcatggcttc 930781 aaaactgctt gatcgtaaag tagaggtgta aatatggaca atcaattcca atcctcgaaa 930841 ccgatttatc tgcagatcgc tgatcagatc ttttataggc tggtcaggaa ggagctgctc 930901 ccaggagaca agcttccttc agtaagagaa atggcgattc aaactaaagt aaatcccaat 930961 acaattcaaa gaacttacag tgagatggaa aggctgggta ttgtggagac aagaagaggt 931021 caagggacgt ttattgcgga aaaagcagaa atcgtagacg agctgaaaga caagctgaca 931081 cgagaggtgc tggaaggctt tgtcaagcaa atgaaagagc tggggctaac gaaagaagaa 931141 atgttagaag ggattaaaac attcacagag ggaggctaaa atggaaatca agctagaaca 931201 tgtatcaaaa aaatacggcc gccatacggc cgtcaatgat gtgtcaatca ccctatcatc 931261 cggacggatt tatggcctga ttggaccgaa cggcagcggc aagtcaacga ccctgaaaat 931321 gatggctggc cttctgtttc cgacttcagg atttgtaaaa gttgatgaag agcaggttac 931381 gagagaaatg gtgcgtcaaa cggcttatct tactgagctt gatatgtttt atccgcattt 931441 cactgttaaa gatatggtga atttttatca gtcgcagttt cctgattttc atacagaaca 931501 ggtttataag ctattgaatg agatgcagct gaatccggaa aaaaagatca aaaagctatc 931561 aaaaggaaat cggggcaggc tgaaaatcgt tcttgcttta gcgagacggg cagacgtcat 931621 cttgcttgat gaaccttttt ccgggcttga tccgatggtc agggattcca tcgtaaacag 931681 ccttgtgtcg tacattgatt ttgagcagca gattgtcgtg atcgcgacac atgaaattga 931741 tgaaattgag actttgttag atgaagtaat catcctcgcc aatggagaaa aagttgcgca 931801 gcgtgaagta gaagatattc gtgaacagga aggcatgtct gttttgcaat ggtttaaatc 931861 aaaaatggaa gtttgctaga aagaggagga atatgatgaa aacagtgttg gaattgaaaa 931921 acgtgactaa aaacatcaga ggccgaacga tcattgatga tctcagtttt acgattcgtg 931981 aaggcgaggt attcggtttt ttaggaccaa acggagcggg gaaaacgaca accatccgga 932041 tgatggtggg gttaatgaag ctgtcgaaag gtgatgtcct catttgcggc caatcaatta 932101 cgaaagaata tgccaaggcg attaagcata tcggagcgat cgttgagaat cccgagctgt 932161 ataaattttt gagcggatat aaaaatctcc agcaattcgc aaggatggtc aagggtgtca 932221 cgaaggaaaa aattgatgaa gttgttgaac tggtcggttt aacagacaga atccacgaca 932281 aggtgaaaac atattctctg gggatgagac agcgtcttgg cttggcacaa tgccttctgc 932341 acgatccgaa agtgctgatt ttggatgaac cgacaaacgg ccttgatccg gcggggatca 932401 gagaaatcag agatcattta aagaagctga cccgagaaag aggaatggct gtcatcgttt 932461 caagccacct gctgtcagaa atggaactga tgtgtgatcg aattgcgatt ctgcaaaaag 932521 gaaagctgat cgatattcaa aatgtaaaag atgaaaacat tgatgagaat gatacatatt 932581 tcttccaggt tgagcagccg agtgaagccg ctactgtttt aaatcagtac gatttgctga 932641 gtaagacaaa tggtgtagaa atcaaactgg ctaaagagga agtccctgcg gttattgaat 932701 tgctggtgat gcagcaaatc cgtatttatg aggtcaaggt cataacaaaa tcattagagg 932761 accgtttctt agaaatgaca ggtgaaacaa aagaggaggt tcagcatgct taatttgatt 932821 tataatgagt ggctcaaaat tttcagccgt gccggaacat gggtgatgat cggaattctg 932881 gggctgacaa tggttggatt tgcatttttg gcgaatcatt tttctgccgg tgaatcaaat 932941 tcccattgga aacaagagct tcaagcacaa aacgccgaat taaagaaaga aatcaaagaa 933001 gatccttcac tgaaagatgg gtataaagaa acaatcacac tcaatgacta tcgcatcgag 933061 cataatatcc ctagtgacac gggctatacg gtatggtctt atgtaacgga ttcagcaaac 933121 tttaccatcc ttaccggtct gtttactatt atcatcgcgg ccggaattgt cgcgaacgaa 933181 tttaattggg gaacgattaa gctattaatg attcggccgc tcagtcgttt tcaaattttg 933241 atgtccaaat atattacagt tctcctgttt gggctcctgt tgctgttgat tttatttatc 933301 ggttctactt tattagggtt gatcttcttc ggaacgggtg gtgaaaccgc cgcgaatatt 933361 catttaatct ataaggatgg ccatgtcatt gagcaaaaca tgatggggca tttggctaca 933421 acgtatcttt ctgaatccgt ctcggcttta atggtggcga cgatggcgtt tatgctgtct 933481 gcggtattca gaaacagctc tcttgcggtt ggtttttcca tcttcttgtt ggttgccggt 933541 acgactgcaa ctgcatttat tgcagcgaaa tttgactggg caaagtatat attgtttgct 933601 aatgtcgact tgactcagta tgtggatggc acaccgttaa taaaagggat gactatgacg 933661 ttttctctcg tcatgctggc gatctacttt atcatcttcc tgttgcttgc tttcggaatc 933721 ttcatgaagc gggatattgc aaactaataa aaaaagctgt tttgcttatg caaaacagct 933781 tttttgtcaa aataaaaact gcaggtttgc acctgcagtt tttcatatca atttatgctt 933841 acgcttcttt agtaacgtta gcagcttgtg gtccgcggtt tccttcaacg atttcaaaag 933901 aaacagcttg gccttcttct aaagttttga agccttcgcc ttgaatagca gagaaatgaa 933961 cgaatacatc gtcttgacct tctacttcga tgaatccgaa acctttttca gagttgaacc 934021 attttacttt accttctaac atgaaatttc ctcctaaagc gatcataacg cttaaattca 934081 ctattcttgc tcttaacaaa ctttcaagac gaaaactctt acaaaacttt cttcttaaag 934141 atagttcgaa caaaaataat tacctttact ctaccagtaa tcttcagaaa aaacaactgc 934201 ttattgaaat ttttttcgga aaataccata tttatttttc aatttgatat ttatttacgg 934261 aaattcatct gttttctcga tatgtgatca tacgtttgcc ttagtattcc ttcattttgg 934321 gaagataagt aataggaatt gacaacctta ttggatatga gtaaggtaaa agttaatcaa 934381 tattacaaat gacaacgttt atcaactaag agagcgtatg atttttatgt ctgatattgc 934441 ttgcatgctc taatacatag ataggagtat ggtcacaatg aaaaagtggc ttatatgcag 934501 tttcgtcctt gttcttctcg tttcatttac tgcatgttca ccgtctgcag aacatgaatc 934561 gataaaaatc gggattgctg agtctgacgg ggcaatatgg aactatattg ctcaaaaggc 934621 tgaagaggca gggctggata ttcagctgat ccctttttct gattatgcgg agtctgatat 934681 cgcacttgct aacaaagaaa ttgatgccaa cgcctttcaa accatttcat attttcagtc 934741 gttcactgaa aaatacaaac ttaatttggc accgctcggg acgacataca taacgcccat 934801 gggcatttat tcaaaacgat atgaacgaat ccgagatata tcgcggggag ctgtcgtttc 934861 tgttccggat aaagcgttcg attttggcag ggcgcttacg gtgctccagg aagcgggttt 934921 gctaacgctg aaaaacggat ttaacggaac aggttcagtt gatatgatta aagataatcc 934981 gagacacctg aaattaaaag ctgtccggca acaggatgca gtgagcggtg ccgacgtgtt 935041 tgtcatgaaa ccatcagaag caaaaaaagc gggcttgaac ccgaaaaagc atacgctaaa 935101 gagcggcgga ctcatgtctg aggaagagat gaatttgatt gttgtcagag cggaggatca 935161 agatcgggaa gcgctgcaaa ccattcttga gctttatcaa gctgatgata cagcggcatt 935221 tatagaaaaa gaatatcagg gagatcttgt cccggctttt ctgcctttga aacgtctttc 935281 agattggaag aatgaattcg aacattgaat tcattctttt ttttctgaaa aacacactct 935341 gttccgtccc gtttctttcg ctttgtaaag catttgatcg gcaagaatgg gcaaggatcc 935401 tggctgttcc gtattattgg ggtaatgagc ggcccctagt gatatcgtaa ctgaaagctc 935461 gtcgccgttt gttaatacaa tcggtgcatc acttacagtg ctcctgatcc gttcagcgat 935521 ccgggctgct ttatcaagag aacagttcgg caggagcacg gcaaattctt caccgccgat 935581 ccgagcggca ggatcagtat ttcggatggt ctgcttcaga cgtaacccta gctctttgag 935641 cacctgatct ccttcatgat ggccatattg gtcattgatg gtcttaaaat gatcgatatc 935701 catataaatc agtgcaaatt gaaaatgcgg ggtatcggcc gcctgctgat acagagcttt 935761 tgtggtttct tcaaattttc ttcggttata cacgcctgtt aaaaagtcaa agtgcgcctg 935821 aaacttatat tgtttaaaaa gaagatgtgc atttgtttca tgatcaataa tatataaact 935881 gagcatgccg cccgctattg atatgatcca aaaatacaaa tgaagttcgt atgaatgtaa 935941 atctataaga aaataaaagg aaaaggagat caagctattt gtgattatta aaagatagaa 936001 agcatgtttt agttgaactt tttttcttct agaaacaatg agtgacggaa tggcagcgat 936061 acaaatgata ataaccgagt atagtgcaga tgtgttcatc gtaatcagca agcggcctgc 936121 agtgatcatg gccagggccg ttgccgttga aacccagcct ccataaagag cggcaatcat 936181 aatagggata tttcgaagat caataattga atgctgatag gtaaatccaa aaaccatcag 936241 aataaccccg agcaaaccgc aggccagtcc tttaacagct tgaaaggata tgctgtcttt 936301 tttatgtact agcctttctt taaacaggtg ggtgaagaga taattaaatg tgattaaaat 936361 ggtcaaattt acaaacagtt ctttcagcaa atattatcac ccttatataa ggtactaaag 936421 atggaaggga aagaaaagaa caaaaaaggc attatataag gtttttttac ttgaattgat 936481 aagttaaaat aattcgcact tgacccatcg gaattagtgt aatatagtaa atgagaaaat 936541 ttgaagggag agtttacctg ctttggagac tttactggtt gtattacatg tatttatttt 936601 atttttactt atcttagggc tctttgttat gcagaaaaaa catgtttcct tctctaaacg 936661 tgtatttact gcgctggggc tggggattgt attcggattt gcgcttcagc tgatttacgg 936721 cccgacttca aatatagtca ttcaaacagc cgactggttt aatattgccg ggggcggata 936781 tgtcaaattg cttcagatgg ttgtcatgcc gctcgtcttt atttcgattc tcggcgcctt 936841 tacaaagctg aagctgacaa aaaatcttgg gaaaatcagc ggtttgatta tcgggatttt 936901 agtagcaaca acagcagttg ctgcagctgt cggtatcgcg tccgcgcttt catttgatct 936961 gcaggcgatt caggttgacc aaggaagtac agagctttca cggggacagg agcttcagca 937021 gaaatcagag gatatgacag cgaaaacgct gccgcagcag attgttgaac tgctgcctgg 937081 aaacccgttt ttagatttta cgggagctag accgacttca acgatcgctg tcgttatttt 937141 tgccgctttc cttggagtgg cattcctcgg cgtaaaacac aaacagccgg aacaggcaga 937201 aacatttaaa aaactggttg atgccgttta tgccattgtc atgcgtgttg tcacactcat 937261 tttgagactg acgccttatg gggtgctggc catcatgaca aaaacaattg caacgagtga 937321 tcttgacagc attctaaaac tgggcatgtt cgtgattgca tcatatgccg cgttaatcac 937381 tatgtttatc attcatttgc tgctgctgac gttcagcggc ttgaatccgg tgatttattt 937441 gaaaaaagcg gtgcctgtac ttgtatttgc atttacgtca aggtctagcg caggtgcttt 937501 accgctgaat attaaaacac agagaagcat gggtgtaccg gagggaatcg caaactttgc 937561 cggttcgttc ggtctttcga tcggccaaaa tggatgtgcc ggcatttatc ctgcgatgct 937621 ggcgatgatg attgctccga ctgtcggcca aaatccattt gacccggtgt ttattatcac 937681 tgttatcgca gtcgttgcca tcagctcctt cggggttgcc ggagtcggcg gcggagcgac 937741 attcgcggcg cttcttgttt tatcatcatt aaacatgcct gtcgcgctcg ccggtttgtt 937801 aatctcaatt gaaccgttaa tcgacatggg gcgtactgct ttgaatgtca gcggaagcat 937861 gacatccggt cttattacaa gtaaggtcac aaaagaaatt gatcaagggg catttcatga 937921 tcaatccaga gtgattgaag ctgaagaagc gtaacatatg aaaacgtgta atccaagagg 937981 attacacgtt tttttaacgg ccaggctcta agtcctccag catttccatc atcgtgttgt 938041 cgtccatgac attcattgcg ttttgttcaa aatgaatggg ttcagcataa tgcggctgtc 938101 tttttttcgc ggctgtctca gtttgcctag tttgagactg tgtatgctga tgctgtggtt 938161 gctgctgtcc agcgtgctgg tgctgacggc cattttgccg ctggctttga tgctgcgaac 938221 ggtcctggtt atcaccgctg cttccgctgc ttccgctaaa tgcttgtttg accatgtttc 938281 ctacattaga agcatcaaac gtgttatttt ctgaatttcg tctgttcatt tgtcctgtga 938341 taaacccgct gattctttgg cggatctgag gtgataatgc agtaataagc atagttgatc 938401 ctatgatcaa tgctgcgggg ctgattcctc ttcgctggtt gaacaacatg atccctcctt 938461 tgcagtgtat tcatattttc cccctcgtta gacaaattaa ccgttatatt tcccgggaaa 938521 gcatttcctc cagatttgca tgcataatta aagccagtta gaaaaaccta taagtaaagt 938581 gataaaggag gaattcacat gtttggaaaa aaacaagtcc ttgcgtctgt gcttcttatc 938641 cctttgctta tgactggctg cggtgtagcc gaccaaggtg agggcagacg tgataataat 938701 gatgtaagaa acgtaaatta tcgaaatccg gccaatgacg atatgcggaa tgtaaacaat 938761 cgggataacg ttgacaacaa tgttaatgat aatgtcaata acaatcgtgt aaatgacgat 938821 aataacaacg accgaaaact tgaggttgct gatgaagcag ctgataaagt aacagaccta 938881 aaagaagtaa agcatgccga tatcattgtg gctggaaatc aagcctacgt tgcagtcgtt 938941 ttaaccaatg gaaataaagg tgcagtagaa aacaatctga agaaaaaaat agccaaaaag 939001 gtaagatcta ctgacaaaaa cattgataat gtttacgttt cagctaaccc tgattttgta 939061 gagcgtatgc aaggatatgg aaagcgtatt caaaatggtg acccaatcgc cggattattt 939121 gatgaattta cacaaactgt acagcgtgta ttccctaacg ctgaataaat gaaagaagcc 939181 gcacaatttg tgcggctttt tctttgcgtt aatgacacac tgcgaactca ggctgcatag 939241 agtaaaaata aaaaggtaca agacggaccg gctcagggag ggagacgttt gcgggatggc 939301 ataggaaagc gtgcggcatc cgctctattc ctgtgcggag tccttgtgat gctggctgta 939361 agctcagcca tcgtatcaag cgcgatgtat atcctgtctt ttccaggtca ggcatctgga 939421 ataacaaaag aacaagtgac gaagcacatg aagaaagagt cattcaaaca ggccgatatt 939481 tattacactt ctaaggaaaa gtccttactg ccattgacga aagaaacgct tgaatatgcg 939541 gtcagtatta atcagattat gattggatat tcgaatcaaa agcctattga cattattttt 939601 tttcctaatg aaaaacagat ggaggcttac tccggtttat tggatgtagt tggtttttat 939661 tctgaacggg agcagctgat cggattgttg cctgaagaga aaaagaaact gttagaaggg 939721 gacgaggtag cggtttattt gtaccagaga ttgttgattc atgaatactc gcaccatgcg 939781 tttcaccaga aattgaagga gcttgagacg gatcccgatg agtttccgtt atggtttcat 939841 gaagggttaa gcgagtggat tgcgaactat gaattgctca tagatccgat cacgttttct 939901 gtcgtgccct ttgaccgttt gcagactgat cgagactggc aggaagctag agccgaatat 939961 gacactgatg tctatttgca aagcttttat atgatcgatg agctgacgga caaatacggg 940021 aaagacatta tttcagaaat gattaaggaa acggcaaaaa aaggggactt tgaaaaaggg 940081 tttaaatcag caacaaagga aagtcttgat caatttgaaa aagattttaa gaaaaaattt 940141 gaaaaaaaca gtgcggcatt ggatagtatc tatccaatgc ctttgttatt agtgaagtcc 940201 ttgctgaccc attccgcctt gtgtcggagg catttgtcct tgggcagggg cgaatgaatt 940261 tcgcagctgt tccatatcct gcgcatcaag ctgaggaacc tggtaatagc cgtgtttgtt 940321 ttggtatagg aaaatttcaa atgccatttc aacatactcc tgaatttgcg cagacagtac 940381 gcgtcttacg gccggatttg tcatttccag agaagccatc gtcagcatag aagcttgtgc 940441 tttaatcgcg caaagcattt gtcggctgat gatgctgtca tcaatatcat tcatggattg 940501 aacaggtttt ttaggctgtg acggctgcat gccgtaaaca gtctggttgt cttccttcat 940561 catataagtt gctgtttttt gtgaaggttc gcttcctgtt ttgaagcatt ctgcagttat 940621 attgtattga gatgtgatga attgatgttg acgatcaagg atgtttagta attcttgatc 940681 cttacagaat tgtctcagca tcataaactg atcaagcaca gtaagtgttc cggaaagcac 940741 ctcatgcata tcaaacattt catgtccgcc gtggttttta tgcggtttgc caggaatacc 940801 tttgttcatt tgggattgct gctgctgatt gaactgatcc aaaccgaatt cctccttttt 940861 tttcagatca gctgtatttt gtgtcagtct gccgtgtatt atgcagaagc ctgaaaggaa 940921 ttatatgctg tctgtcgaaa tgataagcag acaaaatcgt tgtcattatg tgtataaggg 940981 aggaaatatg atgaggcgta ttctgcatat tgtgttgatc acggcattaa tgttcttaaa 941041 tgtaatgtac acgttcgaag ctgtaaaggc agctgaaccg caacagccta tatcgattga 941101 gaaggcaata cagcaaaaag aaggacaggc acttgtcgaa ggatatgcag tcggccaggc 941161 tgtttccccg cagcattata aactgacaag ccctttttca aatgattata atgttgcgct 941221 ggcagaccgt aaaaacaaaa catcgcccga acacatcctt cctgtgcaaa tcccctccgc 941281 cttcagaagc caatttgggc tgcaaaccaa tccgcttctt cttgggaaaa agataacggt 941341 tcaaggaaag cttgaaaatt actttaacac gacaggactt aaaaacgttc agtcgatgaa 941401 cgtaaccgat gacacaaaaa ctccgccggc tgaacagcaa gtgaccataa atgaagcacg 941461 gggaaggctg aatgaagaag taacgataaa agggatcatt acagctgatc aaaacgcaat 941521 cggaggcggg aagctgtcga cctttttgca agatgaaacc ggaggcatta acatttattc 941581 gccatcccct gaacaatttc ccgaattaaa agagggtatg gatgtcacgg tgacagggaa 941641 aatcacgtct taccaggggc tgaaagaaat cgttccaaac tcatcaggca tcaaaatcaa 941701 ccagtcaaat caatccctcc ccgcccccaa acacttaaca atcaatgaac ttattaacgg 941761 cagcctaggt gatcagtatg aaggacgcct tgtgaaacta accgcttttg tttcctcaat 941821 tccaagttct cctgccggcg gcggttacaa tgtaacaatg attgatgacg accatcatgc 941881 aatgacgctc cgggttatga atgaaacagg ggtgataaac gagcttgatg agggcaaatg 941941 gtatgaattt accggtgtgt taagcagata ccaaaccttt cagctgcttc cgcgaaaatc 942001 ggctgacctg aagctgcttg aagagcagcc cgcacctccg tctgcagagg gagaatatga 942061 agggattgtt gaccgggtag ttgacggcga taccattcat cttaaatctc cggtgcttgg 942121 aacgacaaaa atccggtttg taaatgtaga tgcacccgaa acatatcaca caccaaaaaa 942181 tgacgcagat gaaaatcaat taagatttgg caaaaaagca tctgactatc taaaaacggt 942241 tctgtccccg ggtgataaaa ttactgtcaa ggtcgggagt gaagccaagg acagctatgg 942301 cagattgctc ggacaagtca taaccgaatc aggttcaaac gtgaacttag agcttgtaaa 942361 aaacggctat gctccgacgt attttatttg gccggttgac aatgaagagg attatcagca 942421 atttcaggcc gcagtagccg ctgcaaaaaa agatcaaaaa ggaatttgga atgaaaacga 942481 tcccctcatg gaaatgccgt ttgaattcag agccagagag caagggaaag gcctgacaag 942541 atatgtgggg gactcgtcga ataaaacata tgtgcagcca gctgactgga agaagatagc 942601 tgtggaaaac agaattttct tcgcctcagc aagtgaagcg gagagcgcgg gatataaaaa 942661 aaggcaaacg gcacctcaag aacatgtgcc gcttagaatt ctcagcatga atgatttgca 942721 tggcaaaatc gatcagcaat atgagcttga tcttgatgga aatggaactg tagacggcac 942781 gtttggacgc atggattatg ccgccgcata tttaaaagaa aaaaaggctg aaaagaaaaa 942841 ctcgctgatt gtgcacgcgg gagatatgat cggcggaagc tctccagttt cctctcttct 942901 tcaggatgaa ccgactgtag aactgatgga ggacatcgga tttgatgtcg gaaccgtggg 942961 aaaccacgaa tttgatgaag gcacggatga acttctgagg atcttaaatg gcggtgatca 943021 tccgaaaggc acaagcggat atgatggaca gaactttccc cttgtatgtg ccaattgtaa 943081 aatgaaatca actggagagc cctttttgcc ggcttacgac atcattaatg tggagggcgt 943141 acccgttgct tttatcggag ttgtcacaca gtcggcagct ggcatggtta tgcctgaagg 943201 aataaaaaat atcgagttta cagatgaagc aacagcggtg aataaggcgg ccgaagagct 943261 caagaaaaaa ggcgtgaagg ccatcgcggt tctcgcacat atgtcagctg aacaaaacgg 943321 caacgccatt accggtgagt ctgctgatct tgcaaacaaa acagattctg aaattgacgt 943381 gatttttgcc gcgcataatc atcaggttgt taacggtgaa gtgaatggaa aactgattgt 943441 tcaagcgttt gaatatggaa aagcgatagg tgtcgttgat gtagagatcg ataaaacgac 943501 aaaagacatt gtcaaaaagt ccgcggaaat cgtatatgtt gatcaaagta aaatcgaacc 943561 ggatgtcagc gcgtcagcca ttttaaagaa atacgaaaca attgcggaac cgattatcag 943621 cgaggtagtc ggcgaagccg ctgttgatat ggaagggggg tattcaaatg acggcgatac 943681 acctcttgga aacctgattg cggatggtat gagagctgcc atgaaaacgg attttgccct 943741 tatgaatggc ggcggcatac gtgaagcgct gaagaagggt ccaattacgt ggggagatct 943801 ttacaatatt cagccgtttg gaaatgtgtt aacgaagctt gagattaaag gaaaagattt 943861 aagagagatt atcaatgcgc aaatctcgcc ggtttttggg cctgactaca gcatcagcgg 943921 gtttacgtat acgtgggata aagaaaccgg aaaagcagtt gatatgaaaa tggcagatgg 943981 caccgagatc cagcccgatg ccacatatac attgaccgtc aacaacttta tggcgacggc 944041 gacaggagcc aaatatcagc caatcggact gctgggaaaa aatccggtga cagggcctga 944101 ggatttggaa gcgacagttg agtacgtgaa gagttttgat gagccaattg cgtatacaaa 944161 agagggaaga attaagcttg ctgaagccag tgatattgaa gaccctgtaa cagaagaccc 944221 gataacggaa gagcctggag atgatccggg gacggaggat ccgattaaag aggatccaag 944281 gccaggtgaa gatttgcctg atataaaaga aactccggga acagcaccgg ttcatcagct 944341 tccgccttca gccatttcga gattcaatga aataccaatc aacaacacaa aaaccgctga 944401 tactgctaat agcatcagca cattgccgtt acaaaccgag actgcggaaa gcgggtctga 944461 tcatcagctt ccggatacgt cagcgggcta ctataacttt atggtaatcg gtgcggcggt 944521 gacattgtca ggaacttatc tatatgtcag aagaaaaagg agcgcctcca gaacgtgaaa 944581 aaagttattc cactattcat cattgctgcc ggcctagtga tcgcaggcta tggaggcttt 944641 aaattgatcg atacgaatac gaaaacggaa cagacattaa aagaagcaaa gctggcggct 944701 aaaaagccgc aggaagcttc ggggacgaaa aatagcacag atcaagcaaa gaacaaagca 944761 tcatttaagc ctgagaccgg ccaagcgagc ggcattttag aaataccgaa aatcaatgca 944821 gagcttccga tcgtggaggg caccgatgct gatgatttag aaaaaggtgt cgggcattac 944881 aaggacagct attatcctga tgaaaacgga caaattgtgc tgtcagggca tcgggatacc 944941 gtgtttcgcc ggacgggaga gctggaaaag ggggatcagc tccgtcttct cctgtcatat 945001 ggagaattca catatgaaat tgtaaaaaca aaaattgtcg ataaggatga cacatctatt 945061 atcacgctcc agcatgaaaa ggaagagctg attctgacga cctgctatcc gttttcatac 945121 gtcggaaatg ccccgaagcg ctatattata tatggaaaac gagtgactta aaaagccgag 945181 gcagtgcctg cggcttttct tcatgaaaaa tatgtgcggc aaaggttttt catatcagca 945241 gggaaagggg cttcagcaac tatgagctcg tctgttatcg ggtgaaccgc ttgtacttta 945301 ttggcgtgca gtgcctgcct gtttagcagc ttgctcccgc ctccgtaaag cgagtctcct 945361 gtcaacggat ggccgaggct cgccagatga acacggattt ggtgtgttct gcctgtttcc 945421 agctctaatt caacgagcga cagccgttct ttcgcattgc tggccattac cttgaaatga 945481 gtgacggctg tttgcccgcc tggtgaaacc cggcgtcttg tcgggtgtga gcggtctctg 945541 ccgatcggtg aattaattgt cccttttttc gtccgtagct taccttcagc gatagcggta 945601 tacgtacgct tcagcgtctt tttctctaac tgctggtcta agatggcgtg tgccaaacga 945661 tgcttggcaa aaacgatagc gccagatgta tcctgatcaa gacgatggac gtggcgcacc 945721 ttacatgttt cgccatttat ctgataatga tacgcgatca aattagccag tgtgccggtt 945781 tgcccatcct cattcggatg cgtcgcgatg ccagcgggtt tattgatgat gagcatatga 945841 ttgtcctcaa ataaaatatc aagctcgcca tactccggaa tgaccgaaga tgcttcactt 945901 tcctgaagat caatgaacac gcggtctccc ttttttacaa tcatattgtt taagacggat 945961 tcgtgattga cctttatctg ttgatgggac atccagtctt gtatcactgg tttagaagct 946021 ttgagcgctg ttttgagtac ggaaaacagc cattggccgt cctgtttttc attgatgagg 946081 atctcaagcc ctctgccttt ttggttcatg ttaaatggct ccttttcgaa gcggaaggct 946141 gctgtttctc ataggaaaca cttaccttag ctttcgcgtt tttttctgtg ctattcttga 946201 gtaagactta ggatattcga tggcaagaaa ggtgattgac gtgagaattg tgaacgcagc 946261 aactgcagaa caggagagct ttatcaagga gctgtctatg gagctgatcc atgatgtatt 946321 tcctctttat ttctccgaac tggacattca gcgctttaaa aagaaaggcg ttctgtcttt 946381 aaataaccat tattaccaag gaacattaaa agaagcattt caaattatgg cttgtctgca 946441 aatgatacat attatcctga ccaagccttc gccgcactct gatttgagtg atcaggcgat 946501 ttttgaaaaa aacagcaaga tgctgaatga ttttgggatt tattttccgt ttgctttttc 946561 tgactttcaa aagaagacta acaaagcctt tttcggtcaa agaaggctga tataatcatg 946621 cggcaagggc ttttctattt ttagaaaagc tctttttgta tcagagaaat catatcataa 946681 aacctttcct ctaactccct ttttaaacgg ctcgtgtctg aacatactaa tgattgaaag 946741 gggtgctgac aatgagttca gttaaagata caatgacaac gcaggtggca accgtttctc 946801 cgaatcaaac gattcaggaa gcggcttctc taatgaaaca gcataacgtc ggggcgatcc 946861 ccgttgtaga gcaaggtgtt ttaaaaggaa tgctgactga ccgtgacatt gcattaagaa 946921 ctacagctca gggccgtgat ggccagacac ccgtttcaga agtgatgtca acagaactcg 946981 tatcaggaaa ccctaatatg agtctggaag acgcgtcgca gctgatggcc cagcaccaaa 947041 tccgccgcct tcctattgta gatcaaaaca atctagtcgg gatcgttgcg cttggagacc 947101 tggcagtcaa tcagatgtcg aacgagtctg cgggatcagc gctgacaaac atttctcacc 947161 aaaacattca ttaataagaa agagcttgca gtgtgcaggc tctttcttca cataaaacct 947221 tactttttga aagcagactt gtttcggggt atagtgagtg tatacatatg tctcaattcg 947281 tactaaagga gttgtaccca gtgattaaag cgttaatttt tgattttgac gggcttattc 947341 tagatacaga aacacacgaa tatgaggttc ttcaggaaat atttgaagag cacggctcag 947401 tgctgccgct atctgtctgg ggaaaggtca tcggaactgc tgcgggtttc cggccttttg 947461 aatatttaga agagcagatc gggaaaaagc tgaaccatga agagctcaca caattgagaa 947521 gagagcggtt tgccaaacgc atggaatcag aaaaagcgag acctggtgtc gaagcgtatt 947581 tgaatgcggc aaaggattta ggcttaaaaa taggccttgc ctccagctct gattataaat 947641 gggtgtccgg ccatttgaag caaatcggcc tgtttgatga ttttgaagtt attcaaacgg 947701 cggatgatgt ggaagaggtg aagccgaatc ctgaactcta tttattggcg gcaaagaacc 947761 tgggggtatc gccagcggaa tgtctcgcgt ttgaggattc tgtcaatggt tcgattgctg 947821 cgaaacgtgc aggcatgaag tgtgtcattg tcccgaataa agtaacgggt accttgatgt 947881 ttgaagacta tgatcacagg cttgaatcaa tggcggagat ggagctcgcc ctattgcttg 947941 atcatctgaa ctcacaaaac tagaaaggag cgagtaggtt gtctgagaaa ttagatttga 948001 cccggtttga aaagaaaatg gttatccgca atatcgaaga gaaagacatc gacaagatta 948061 tcgatcttca aaaggactgc tttccaggaa tggagccttg gaagcgggag catttaatca 948121 gccatttgga gcattttccg gaaggacagt tttgtgcaga attcgaaggt gaaattatcg 948181 gttcgtgctc aagtctcctg attaactttg atgaatatga tgaccgccat acgtggcagg 948241 acattacaga tgacggttat atcaccaacc ataatcctga cggcttgaat atgtacggaa 948301 ttgaagtcat ggtgcacccg aaatacagac gaatgaagat cggccaccgt ttgtacgagg 948361 cgagaaagga cttagccaga cgcttaaacc tgaaaagcat catcataggc ggacggattc 948421 caaactatca caaatatgca gaggaaatga cagcgagaga gtatgttgaa caggtgacac 948481 gccaccaaat ttacgatccg gttctttctt ttcagctgat gaacggcttt acccttatgc 948541 gaattaaccc gaactatctc ccggatgata cagcttcgat caagtatgcg acgctgatgg 948601 aatggaataa tgtcgattat ctaccgcagc agacaaaacg ctattataaa tcggcgttcc 948661 ctgttagaat ttgtgtgatc caatacgaaa tgaagaaaat ttattccttt gaggaatttg 948721 cgaatcaagt agaatactat gtcgatgttg cttccgacgc aagatctgat tttgcggtgt 948781 tcccggaaat tttcacaacc cagctgatgt ccttccttga ggaacggtca ccgagcttgg 948841 cggtgcagag aattaccgag tatacagaag attacatcag cctgtttact gacttggctg 948901 tgaagtataa cgtcaacatt atcggcggat ctcatttcgt cgaagaggaa ggcaagatct 948961 ataatatcgc ttacctgttc agacgggacg gaacgatcga gaagcaatac aaactccata 949021 ttacgccgaa tgaacgcaaa tggtggggga tcagcgcagg agaccaagtt cgcgtgtttg 949081 atacggactg cgggaaaatc gcgatccaga tctgttatga cattgaattt cctgagcttg 949141 cccggattgc ggctgataaa ggagccaaaa tcatctttac gccattttgt acagaagacc 949201 gtcaaggcta tctgcgtgtc agatactgtt cgcaggctag agcggttgaa aatcaaattt 949261 atacggttat ctctggaacg gtcggaaacc ttccgcaaac ggaaaacatg gatatccaat 949321 acgcccagtc aggcatcttt gccccgtctg attttgaatt cgcccgagac ggcattgtcg 949381 gcgaaacaaa cccgaatatt gaaatggtcg tcatcggcga tgttgacctg gaaattctca 949441 gaagacagcg ccaaaacggt acagtgcgcc agctaaaaga cagacgacgt gatatttatc 949501 atattcaata taaaaaataa ttcccaaaaa acccgcctga attggcgggt ttttttaaac 949561 aaaagcggaa ttgtttaggt gctttcttta aaataaaagt aaattgtata gtggatgtgc 949621 cttatggagt ttctgtattt tcgccatttc ctatatcata cagaaaacgg ctaggcttca 949681 cattgctatt gcaatggctg tccaagttgt ttcgagtgcg acctttatca gtacgatgct 949741 gagcattgtc actttgcctg ttttgctttg gaagctgcat cctctttctt cttgagaaag 949801 gggatgtttt attatttacg cggtttattg actctgaccc ggtctggctt tatattgaag 949861 gcagggaaat catcaccaag acatcacata aagagaaggt ctgtttcaat tgaattggca 949921 ttatagggaa cgctaatgaa atggagatga tggggatgga aaacattcag caaaatcagg 949981 gattaaagca aaaagatgag caatttgtgt ggcatgccat gaagggagcg catcaagcgg 950041 acagcctgat agcccagaag gccgaagggg cctgggtaac cgacacagac ggacgccgct 950101 atttggatgc gatgtccggt ttgtggtgcg tcaacattgg ttacggcaga aaggagcttg 950161 cggaggctgc ctatgagcaa ctaaaggagc tgccttacta cccgttaacg caaagtcacg 950221 cacccgcaat tcaactggcg gaaaagctga atgaatggct tggcggcgat tatgttattt 950281 ttttttccaa cagcggatcg gaagcaaacg aaactgcttt taaaattgcc cgccagtacc 950341 atctgcaaaa cggcgaccac agccgttata aattcatctc aagatatcgg gcataccacg 950401 gcaatacatt gggagcgctc tcagctaccg gacaggcgca gcggaaatat aaatacgagc 950461 ctttgagcca agggttcctg catgcagctc cgccagatat ataccggaat cctgatgatg 950521 cagacacgct tgaaagcgca aatgaaatcg accgcatcat gacatgggaa ttaagcgaaa 950581 cgattgccgg ggtcattatg gagcccatca ttacaggcgg aggcatccta atgccgccgg 950641 acggatatat gaagaaggtg gaggacattt gccggcgcca cggagccctt ttgatttgcg 950701 atgaagtgat ctgcgggttt ggacggacag gtgagccgtt cgggtttatg cactacggtg 950761 tgaagcctga tatcattacg atggcaaagg gaatcacaag cgcgtatctg ccattgtcag 950821 cgactgctgt gaaacgggac attttcgaag cgtatcaggg ggaagctcct tatgaccgtt 950881 tccgccacgt gaacacgttc ggcggaagcc cggctgcctg tgctttggcg ttgaaaaacc 950941 tgcaaattat ggaggacgaa cagctgattc agcgatcccg tgatcttgga gcaaagcttt 951001 taggtgagct tcaagctctg agagaacacc cggcagtcgg ggatgttaga ggaaaagggc 951061 tgctgatcgg aatcgaactc gtcaaagaca aattgactaa agagccggct gatgccgcca 951121 aagtaaacca agtggttgcg gcgtgcaaag aaaaagggct gatcatcggc aaaaacggcg 951181 atacagtcgc cggctacaac aatgtcatcc agcttgcgcc gccattttgc ctgacagaag 951241 aggacctttc ctttatcgtg aaaacggtga aagaaagctt tcaaacgata taatataaaa 951301 gtgaattatt aaaggagcac atgatgagtt ttcacaacca gccgatctta ccggctattc 951361 gcaatatgaa gcaatttgat gagtttttga acagttcatt ctcttacggt gttattcttg 951421 atattcatct cggccagctg aagggcgtga tcaaagaagc gcaaaagcac ggaaagaaca 951481 tgatggtgca cgtcgatctc attcaaggga ttaagcatga cgaatacggt gcggaattta 951541 tatgtcagga tatcaagccc gctgggatta tttccacaag atcgaatgtg attgccaaag 951601 cgaagcagaa gaaaatttat gccattcagc gcctgttttt gcttgataca agcgcgatgg 951661 agaaaagcat ggagtttatc ggcaagcata agcctgactt catcgaagtg cttcccggca 951721 tcgttccgtc actcattcag gaaataaaag agaaaacagg gattcccatc tttgccgggg 951781 gtttcatccg tacggaagag gatgtagagc aggcattgaa agcgggggct gtagctgtca 951841 caacatctaa taccaaattg tggaaaaaat atgaaaactt tttgacggaa agtgattgac 951901 accgctttca tgcactgata caattgcact aggttaatac attgtgatgg agaactcgga 951961 gaccacagca gctctttacg gcaaatgttt atgcacccgt aaagcggttt gttgtggttt 952021 ttttattctc ttcttctcta tcatgctttt taatcgtgac tttaggagga atgtgctatg 952081 acagcatttt ggggagaagt catcggtacg atgctgctta tcatttttgg tgcaggtgtt 952141 tgtgcaggtg tcaatttaaa gaaatcgctt tcattccagt ctggctggat tgttgttgta 952201 tttggatggg gattgggtgt tgccatggcg gcatacgcgg ttggcggcat cagcggtgcc 952261 catttgaatc cggcgctaac gatagcgctt gcatttgtag gagattttcc ttggaaagag 952321 gttccggttt atattgcggc gcaaatgatc ggagcgatca tcggtgcggt gattatttat 952381 ctgcattacc tcccgcactg gaagtcaacg gatgatcccg ctgccaagct gggtgttttc 952441 tcaacagggc ccagcattcc gcatacattt gcaaacgttt taagcgaagt gattgggaca 952501 tttgtccttg tacttggaat cttggccata ggtgcaaatc aatttacaga aggacttaat 952561 cctttaatcg tcggtttcct cattgtagca atcggtattt ctctgggagg caccaccggc 952621 tatgctatca atcctgcacg tgacttaggt ccgcggatcg cccacgcttt tcttccgatt 952681 ccggggaagg gctcatcaaa ctggaaatac gcatgggttc cggtagtcgg cccgatttta 952741 ggcggatcat tcggcggtgt attttacaac gctgcattta aagggcacat cacaagcagc 952801 ttctggattg taagcgttat attggttgtg gtattgttag gactctatgt ttatacgaaa 952861 tcacattctg ctaaaacatt atcaaattct aaatatattt aatcaaaggg gagacatctt 952921 atggaaacgt acattttatc cttagatcag gggacgacaa gttcaagagc gattctgttt 952981 aataaagaag gcaaaattgt ccactctgct caaaaggaat ttacacaata cttcccgcat 953041 cctggctggg ttgagcataa tgccaatgaa atttggggct ctgtcctcgc ggttatcgcc 953101 tcagtcatct ctgaatcagg aatcagcgct tctcaaattg ccggcatcgg catcacgaac 953161 cagcgcgaga cgacggttgt gtgggataaa gatacaggaa gtcctgtcta taatgcaatc 953221 gtttggcagt ccagacagac gtccggcatt tgtgaggaac ttcgtgaaaa aggatataat 953281 gataaattca gagaaaaaac agggctttta atcgatcctt acttctccgg cacgaaggtg 953341 aagtggattt tagacaatgt ggaaggcgca agagaaaaag cggaaaaagg cgagctgctg 953401 tttggaacga ttgatacgtg gctcatttgg aaaatgtcag gcggaaaagc gcatgtgacc 953461 gattactcca atgcctcaag aacactgatg tttaatattt acgatttaaa atgggacgat 953521 gaactgctcg acattctagg cgtaccgaaa tccatgctcc ctgaagtgaa gccgtcctct 953581 catgtgtatg cggagactgt tgattatcac ttcttcggaa aaaatatccc gattgctgga 953641 gcggcaggcg accagcagtc cgcattgttc ggccaggcat gctttgaaga aggcatgggg 953701 aaaaacactt acggcacagg atgtttcatg ctgatgaata ccggggaaaa agcaattaag 953761 tccgaacatg ggcttttgac aacaatcgct tggggcattg acggaaaagt gaactatgcg 953821 ttagaaggga gcatttttgt cgcaggctct gccatccagt ggcttagaga cggtttgaga 953881 atgttccagg attcatcgct aagcgaatct tatgcagaaa aagtggattc aactgacggc 953941 gtgtatgttg ttccagcatt tgtcggactg ggaacgcctt actgggacag cgatgtgcgc 954001 ggttcggttt tcggcctgac aagagggaca acaaaagagc actttatccg tgcgacactg 954061 gagtcattgg cttatcagac caaagatgtg cttgacgcaa tggaagcaga ttcaaacatt 954121 tcattaaaga cgctccgtgt agacggagga gctgtaaaaa acaatttcct aatgcagttc 954181 caaggagacc tgttgaatgt tcctgtggag cgcccggaaa ttaatgaaac gactgcactt 954241 ggcgcggctt atttggcggg tatcgctgtg ggattctgga aggaccgttc tgaaatcgcg 954301 aaccagtgga atctggataa acggtttgag cctgaattgg aagaagaaaa acgaaatgag 954361 ctgtataaag gctggcaaaa agccgtgaaa gcagctatgg cttttaaata aagtaatact 954421 atggtataat ggttacaagt taataagaac ggtcctgaga tgaggagaga ccacagcacc 954481 aaagtgtaag catgcacttt ggctgttgtg gtctcttttt ctatttaccg tgacaacaag 954541 gaggaaacgt aatgatgaat catcaatttt caagtcttga aagagatcgc atgctgacag 954601 acatgacgaa aaaaacatat gacctattta ttatcggagg aggaattaca ggagccggaa 954661 cagctcttga cgcggcatca aggggaatga aggtcgcact aagcgaaatg caggactttg 954721 cggcgggaac atcaagccga tcaacgaagc tggtacatgg cggcttgcgc tatttaaaac 954781 aatttgaagt gaaaatggtc gctgaggtag gaaaagagcg ggcgattgtg tatgaaaacg 954841 gcccgcatgt cactacaccg gaatggatgc tgcttccgtt tcataaaggc ggcacattcg 954901 gttcatttac aacatctatt gggttaaggg tttatgactt ccttgcaggt gtgaaaaagt 954961 cagaacgaag aagcatgctt tcagcaaaag aaacgctgca aaaagagcct ttggtgaaaa 955021 aagacggctt aaaaggcggc gggtactatg tggaataccg cactgacgat gcgagactga 955081 ccatcgaagt catgaaggaa gcggttaaat tcggggcaga gcctgtgaat tactccaaag 955141 tgaaggagct tctttacgaa aaaggcaaag ccgtcggcgt attaattgaa gatgtgctga 955201 caaagaaaga atataaagtg tatgcgaaaa aaattgtcaa tgctacaggc ccttgggtcg 955261 atcagctcag agaaaaagac cattcgaaaa acggaaagca tttgcagcat acaaaaggca 955321 ttcaccttgt atttgaccag tctgtctttc cgctgaaaca ggctgtatat ttcgatacac 955381 ctgatggccg gatggtattt gcgattcctc gtgaaggcaa aacatacgtg ggaacaacag 955441 acactgttta caaagaggcg ctggagcatc cgcggatgac aacggaggat cgtgattatg 955501 tcatcaaatc aatcaattac atgttcccgg aactgaatat cactgcgaat gacatcgaat 955561 ccagctgggc ggggctgcgt ccgctgattc atgaagaagg caaagatcct tctgaaattt 955621 cacggaaaga cgagatttgg acatctgact caggcctgat caccattgcc ggcggaaaac 955681 tgactggata cagaaaaatg gcggagcaca tcgttgatct tgtccgtgat cgcttaaaag 955741 aagagggcga aaaggatttt ggaccatgta aaacgaaaaa catgccaatc tctggcgggc 955801 acgtcggcgg ttcgaaaaat cttatgtcct tcgttaccgc gaaaacaaaa gaaggaattg 955861 cagccggttt atcagaaaaa gacgcaaaac agcttgcgat cagatacggc tctaacgtag 955921 atcgcgtctt tgaccgggta gaagcgctga aagatgaggc cgcgaaacgc aacattccgg 955981 ttcatattct tgctgaggca gaatacagta tagaagaaga gatgactgca acccctgctg 956041 acttctttgt ccgcagaacg ggacgtttat tttttgatat caattgggta agaacatata 956101 aagatgccgt tattgatttt atgagcgagc gattccaatg ggatgagcag gcgaaaaaca 956161 aacatacaga aaacctcaac aagcttttac acgatgcggt cgtaccgctt gagcaataaa 956221 tcataacggg ctgtctgcag cccgttattt ctttttacgt gccgaaaggg ggagatctca 956281 ggttatcaag tgacagaggc acccgcttca tataaaataa tggcataagc tgatacatag 956341 gaggacgaat atgacttgga gaaagagcta tgaacgctgg aaacagacag aacatttaga 956401 tctggaatta aaagagcgcc ttattgaatt agagggagat gaacaggccc ttgaggactg 956461 tttctataaa gaccttgaat tcggtaccgg cggaatgcgc ggggaaatcg gcgccgggac 956521 aaatcggatg aatatttaca ctgtgcgcaa agcatcggcc gggtttgcgg catacatctc 956581 gaagcaaggt gaggaagcga aaaaacgggg cgttgtcatt gcttatgatt cccgccataa 956641 gtctccggag ttcgcgatgg aagcggcaaa aacacttgcg acacaaggca tccaaacata 956701 cgtgtttgat gagcttcgcc cgacgccaga gctgtcattc gctgttagac agctgaacgc 956761 ttatggtgga attgtggtaa cggcaagcca taacccgcct gaatataacg gctacaaagt 956821 atacggggat gatggcggcc agctgcctcc aaaggaagcg gacatcgtca ttgagcaggt 956881 aaacgcgatt gaaaatgagc tgacgatcac agtggacgaa gaaaataagt taaaagaaaa 956941 aggcttaatc aaaatcatcg gtgaagatat tgataaagtt tatacagaaa aactgacgtc 957001 catttctgta catcctgaat tatcggaaga agtagatgta aaggttgttt tcacaccgct 957061 gcatggaact gcaaataaac cggtcagacg cggtcttgaa gcactcggct acaaaaatgt 957121 aacggttgtc aaagaacagg aactgccgga ttcaaacttc tccactgtta catcgccgaa 957181 cccggaagag catgcggcat tcgaatatgc cattaagctt ggggaggagc agaatgcaga 957241 tattctcatc gcgacagatc ctgatgctga ccgcctcggc atcgcggtga aaaacgatca 957301 aggcaaatat acagtgctga caggaaacca aaccggagcg ttgctgcttc attacctgct 957361 ttctgaaaag aaaaaacaag gcatcctgcc tgataacggt gttgttctca aaacgatcgt 957421 cacaagcgaa atcggccgtg ctgtagcttc ttcattcggc cttgatacga ttgatacgct 957481 gacaggcttt aagtttatcg gtgaaaagat taaggaatac gaagcatcag gccagtatac 957541 cttccaattc ggttatgaag agagctacgg ttatttaatc ggggattttg cccgcgataa 957601 ggacgccatt caggctgcgc ttttggcagt tgaagtttgc gcgttctata aaaaacaggg 957661 aatgtcattg tatgaggcgc tcatcaatct ctttaacgaa tatggttttt atcgtgaagg 957721 gctgaaatcc ctgacgctga aaggcaaaca aggagcagag caaattgaag cgattcttgc 957781 ttccttcaga caaaatccgc cgcagaaaat ggcgggcaaa caggttgtca cagcagaaga 957841 ttacgctgta agcaaacgga cgcttctgac tgaaagcaaa gaagaagcca tcgacttgcc 957901 aaaatcaaat gtattgaaat acttcctgga agacgggtct tggttctgtc tccgtccttc 957961 tggaactgag ccgaaggtta aattttattt cgccgtaaaa gggtcatctt tggaagacag 958021 tgaaaagcga cttgccgtcc tttctgaaga tgtaatgaag acggtggatg aaattgttga 958081 gtcaacagca aaataattca agtatgagct gggtcattgt aaatgatccg gctttttctt 958141 tttctcatcc aaaagtctga aagaaaatca tcctacaagt gaagcaatga aatacaaaaa 958201 actggtataa tcttaaatac aagatcaatg ccggagtgag aaacgtgagc aaaacgagga 958261 tggaaaaatt aaaaacgctg aaaacgattg cggaaacctt aaatcaaggg cacgatatca 958321 aagcaacact ggatgaggtt ttaaaagagt tgctgagtct gacaaacctt caatccggat 958381 ggatttttct gatcgaagaa gatgggtctt atacgttagc ggccgacgct tatctgcccc 958441 cggctttaag ccgcaaggaa aaagtgctga tgtgcgaagg ggagtgttac tgcctgacga 958501 aattcaataa cggagggctt agaaaagctg caaatatcat gaactgcaaa cgcatcgaat 958561 cagcagaaaa cctgcattgt tttgacacag aagggattac gcatcatgca actgtgcctt 958621 tagaagacgg ggacagaaga ttcggattgt taaatgtagc ggcggccgga aaaaccatgt 958681 ttgatgagga agagctgcat ttactcgagt ctgtcgcctt tcagatcgga acggcaatcc 958741 agcgtatgag gctttctgaa tatcaacaaa aaaatgctct tttaatggag cgtaaccgcc 958801 tcgctcagga gcttcacgat tcagtcaatc aaatgctgtt ttccgtcagt ttaactgcca 958861 aagctgcgaa gacactaaca aaagatgaaa atttacagca gatgattgat ttcatccaaa 958921 acctatcaca ggacgcgctc gcagaaatga aagcgttaat ttggcagctt cgccccggag 958981 gattggaaaa agggctggct gaagccatta aaagctatgg tgcgctcatt ggattgaaga 959041 tcatttttac acaaaaaggc tgtcctgttc tgactgatga gcaggagcat atgctatggc 959101 gtgtcgtaca ggaagcttta aataactgca aaaagcatgc cggaacggat acggcgtatg 959161 ttagtctgac tgcttctttg tgccatgcgg agctggatat catcgatcat ggggcaggat 959221 ttcgctatga agcgcatgcc ggtctgcctt cacttggcat aaaaggtatg aaagagcgag 959281 cggaaaaagc cggagctaag ttttggattg agtcagcgct tggaactgga acaaagctgt 959341 ccatcaggct tccgctaaaa agccgaaaag gaggggcggt atgaaaattg tcattgctga 959401 tgatcatcat gttgtcagaa agggtctgcg ttttttcttt gccacccagg atgatattga 959461 agtcgtcgga gaagctgcaa ctggattaga agccctccgt gtcatcgaag agacaaagcc 959521 ggatcttgtg ctaatggatt tgtctatgcc cgagatggac ggcattcaag ccattaaaaa 959581 agcaatacag caatttccgg atacgaatat cattgtgctg acgagctact ctgatcagga 959641 gcacgtcatc cccgcgcttc aggcaggcgc gaaggcgtat caattaaagg atacggagcc 959701 cgaggaattg gtgaaaacac gacaagtgca tggtggcgaa tacaagcttt ctacagctat 959761 tatgccccat gtgctgacac atatgaaaaa tcagcacgac ccggaaaaag aaaaatacta 959821 tcaattaact agaagggaaa aagacgttct gactgaaata gcgaacggga aaagcaataa 959881 agaaatcgca gcagccttgt ttatttcaga aaaaacagta aaaacccatg tatcgaatct 959941 tttagcaaaa cttgaagtgg ccgatcgcac gcaagcagcg cttttcgcag tgaaatataa 960001 cctgaatgga gagatctcaa aatgaacatg ttagtcataa atggcacgcc aagaaaacat 960061 ggcagaacaa gaattgcagc atcctatatt gcagctctgt atcacacgga tttgattgat 960121 ctaagcgagt ttgtattgcc cgtttttaac ggtgaagcgg aacaatctga actgttgaaa 960181 gtacaggagc ttaagcaacg cgttacgaaa gcggatgcga ttgtattatt atcgcctgaa 960241 tatcacagcg gcatgagcgg cgctttaaaa aatgccttgg attttctaag cagcgaacaa 960301 ttcaaatata agcccgttgc attattggca gtagcgggag gcggaaaagg cggcatcaat 960361 gcgctgaaca atatgagaac tgtgatgcgg ggtgtctacg ccaatgtcat tccgaagcag 960421 ctggtgcttg atccggtgca tattgatgtt gaaaatgcta cagtggctga aaacattaag 960481 gaaagcataa aagagcttgt cgaagaactc agcatgttcg caaaagcagg aaatcccggc 960541 gtctaaacgc cgggatttgt ttatgtgaga agggctattt gatcttcata agtcagctct 960601 gtggcatgat caatatatcg gagaagggaa tacagcatct tttctaaaac ggcgtaatcc 960661 tgttcaaaat gatacgcatg cagaaaatgc tcaattcgtt ttgataacaa atcgtcctct 960721 gtacgcacca ttaaaattaa taaattatcc cattgagaac gatgggtgta ataaagcgct 960781 ttatcgtaat cggcataatc catgaatcgc ttctcctttc ttgggtgaga agttcatgat 960841 tagtttatgc cgcatcctct gttattgacg gggcaaaact tgccgtctgc gtcagtaaag 960901 gggtagcaat atgagggaga cataaaatca aaatgcctga atgaagatat cgcttttggt 960961 aaacctatga gggaatatat tctgggtaca ggagactgaa aaaatgaaat ccctgccgta 961021 taccatcgca cttctttttt gcggattgat tatcgtgtca atggctgcaa aaggtcattc 961081 aacggacaca gacgagtccg ttcaaaagtg ggaacagctt gcctggagca aaattcagga 961141 tgaatataag ggcgcttcat tttctgatta tgcttatatg gggcgtacag aggtgaatga 961201 tcagcagact aaagatgtct ttcgggtgac agtcagacag aaagatgaca ctttttctgt 961261 tcgggccgaa gtctattttc atccggtgac aaatcatatg atcagcatca acgtctttag 961321 gctctaataa aaaactgtac agccgttaag gccgcacagt ttctgttttt agaaatatcg 961381 ttttgcaccg agatagcgct gtttccagta agagttgttc atattggaaa tgacaactcc 961441 ggaatcgttg gcatttatga attccccgtt gcctaggtaa attccgacgt gggaagggcc 961501 ggctttatat gttgaaaaga aaacgaaatc tccgacagca ggctggctaa ctgatttcat 961561 tgtgttccaa tatcccgctg ccgttaatct agatacggat gtgactttgt tcagtacata 961621 gtaaatgaat ccgctgcagt caaacccgga cggtgtcgtg cctccccagc gatacggaac 961681 cccaagctgc gctttagcgg ccgaaatcat tgtgttaatc ttcgcactcg ttgagctggt 961741 ggtgtttgaa gaaccggatg aagacgatga tgaagctttt ccggaaatga ccagcttttg 961801 gccaacctgc aagacatccg tttttaaatt gtttttctca cgaatctgct gagctgttac 961861 attaaatttt tgagcaatca cccataagga atcaccgctt ttcaccgtgt atgtagtcgt 961921 cgtgccggag cttgcatttg acgaagaaga cgacgatgat gaagagcctg aagatgcttt 961981 acctgtcagc ttcaatactt gtccaacgta aagcacatct gatttcagat tgttgatatt 962041 tcggatttgc tgtacagtca ggttatagtt gtttgcgatt ttccaaagtg aatcaccgct 962101 tttaacggta tatttagttg ttgctgaagt ttggttcgat ttggatgaat tgtctttaga 962161 agacgtatca gagccgcttg attttgtttt caacacctga ttcacgtaaa tggtgtctga 962221 ttttaagttg ttcaagacct tcaattcagc gatggacata ttgactttgt ttgcaatttt 962281 ccaaagtgaa tctccaagct gcaccttata tgttcccgta gaagatgaag aacttgaact 962341 cttattagaa ctgctttttg aactggagct tgaactctta ttagagttgc tttttttact 962401 ggaactagag cttgaagaaa cagtaccgga cacctttaat ttctgcccag cacgaattaa 962461 atcgctgctt agtccgttta attttttcag ttcctgcacc gtcattttaa actcatttgc 962521 gatcagccaa agtgaatctc cgcttttcac tgtgtaaaca gaacttccgc tcttcttggt 962581 tgttgagctt gaagtagatg aagaagtgct ggatttgctg cctggaatag taagcgtctg 962641 gccgatcgac agaacagtag tcgaaagatg attggcggat gtgagggccg ccacacttgt 962701 gttataggtt tgggccagtt tccataaaga atctccgctt ttgaccttaa tcgttgctgc 962761 ttcagctggt gtcactacta aagttgtgcc gacaatcgca gatgctgtca gccctgctgc 962821 taatttcttt ttcatcttag ctctcctttt tcccccaatg attttgcatt tgctgtttct 962881 tttttatatc ggcacatttg tctcatcgtt ttgccttttt ataaaaatag ccaaattatc 962941 ttaacaataa gggggaaaaa gggcataaaa aaagaaggaa tcttaatcta ttccttcatt 963001 tttaaaagct tcatgatatc ttctttgttt ttgacgaggt cgcgcagtgt gtatttgtct 963061 aaaactgcga ggtaggctaa aagcgcttca ttcagcacat gttttaagcc gcaaaccggg 963121 gaaataacac agagattctt gttcgcatca aaacattcaa caatattaaa atcgtcctcc 963181 gtttttctga caacctcacc gatgttgatg tcttcagggt ccatgcctaa tcgtatgccg 963241 ccgccccgtc cgcgtatcgt ttctacgtag ccgagctggc cgagcctgta tatgactttc 963301 atgagatgat tttttgaaat agaatacgtt tcggcaatct gttttatatt tgaaagttct 963361 ccgggacgct ctgcagccag aaaaatcaac actcttaatg aataatctgt ataattggtt 963421 aacttcataa taagacctca gaataagaca ttttctatat cttatcataa tcgattgaaa 963481 aatgaaaaaa aaggaattaa aaaacatgca cccagctggg tgcatgtttt ttgcttacat 963541 gtcattcggc ggattttggt ttttacggtt tttttcgatt tctgtgtttt gcattttgcg 963601 ttcaaatgta gacagataac gtgatgcaaa atccttaccg ccaaggccga aggataaacc 963661 aaaagcaagt gcgaagccgc taagaacgat gatgaacgcg gaattgacga ttgtcgcagc 963721 gacacccagc tgatccaggg ccataaagaa agcaagtgcg ataatcgtat atttagcaat 963781 aggcgctaaa gacttgaatt cctgaccttt tatcatgctt gcgagcactt ttctcaccaa 963841 ttctcctgcg taaaggccga gtccgagaat gaatactgcg acaaggacat tcggcagata 963901 cgcgatgatg ccggtggcaa tttctacgag gaagtgcagc cgaacaattt gaagcgcctc 963961 agctgtaaag agcagaatga caatgatttg cgcaatcata ccgacaactt gagacaagga 964021 cagctttgca ggcgttccgg cttccatgcc cattttccct aagacagaat caaagcctgc 964081 gcgatggagc agtccggaca ccatggattt cacccatttt cctgcccaga tacccgctaa 964141 tacaagcacg atggcaatca tgatgttcgg aagcatgttt aaaatcgtat tcagcataga 964201 gacagctggt tttgaaatgc cggcgacatc cagctgatca agcgctgaaa tgaccaccgg 964261 aatcataatg agcacataag cgattgttcc gatgactgct gaaaggcttg tgtcttttaa 964321 gtaaattgat aaacccatac gtgccgcgaa tctttcggtg ccgatgcttg caaggaaatt 964381 cgtaatgata tcacggacaa ggcgggcaac aagccatccg attaatacga taagcgccgc 964441 tgcaaataat ttcggcagaa aagcgagcac gctttccatc atatttgtaa aaggacctga 964501 aatgccgctg attttcaaag aagataagac ccctggcaga aaaacaagca gcacgagata 964561 aaagacaatt tgtgaagcgg tattgacagc ctggtgaata tcttttcctt cagacaccaa 964621 attccacttg cgcagtttgt cactcgtgtt cagcttcatc ccgatttttt tgacaaggaa 964681 gctcaaaaca gaagctgcag cccatcctaa cagcagaatg agtccggctt tcagcacgct 964741 tgggatcgca gctgcaatcg ccgaaagcat actgacaaac ggcgatgcca ctgttgtcag 964801 gtgcaaaatg ttaaagaata aaataaagac gatgatcagt gcgataaaat aaacgacctt 964861 gcttatgact ttttccgagg aatagcgtga aggctttttc ccagcaaaga gcttgtcgtc 964921 gatttttgtt ttgctgagtc ctttgtatac cgctttttca atgattttag caatagccca 964981 gccgattaat aagacgagta aagcaatgat tacgtttggc agcttactga gataagaaga 965041 aaacacgtct gctacattca attggtatcg ctcctttttc gtagtatggt gtgtgtttac 965101 ccacttatcc aataagcaaa cagatgaatg tgccggggga attttttctt gcccgagtga 965161 gactatcatc ttttgtctgg cgggctcata cattatagat aagtccaagt aggggggatt 965221 cggttgaacg cggaggagaa gaagggatta cagcgggcaa ttgaggaaat taccgaaatt 965281 gcaaaaggat tcggccttga tttctacccg atgagatatg aaatctgccc ggctgaaatt 965341 atttatacat ttggcgcgta cgggatgccg acaagattca gccactggag cttcggcaag 965401 cagtttcaca agatgaagct gcactatgat ctagggttaa gtaagatcta tgagctggtc 965461 attaactcag atccatgcta cgcttttttg ctggacagca actcactgat ccaaaataaa 965521 ttgattgtcg cacacgttct tgctcattgc gatttcttca aaaacaactg ccgtttccaa 965581 aacacgaagc gcgatatggt ggaaagcatg gcggcaacag ctgaacggat aaaacactat 965641 gaacaggttc acgggataaa agaagtcgaa tcttttttag atgcaatcct ttcgattcag 965701 gagcatatcg atccgtcgtt ggtccgacca aagctccaat ggagtgtgga tgatgaggaa 965761 gaggagattg aagaggcagc cacgccttac gatgatctat ggtctttaga tgaaaagaaa 965821 ccgaaaaaac aagtgaaaaa atcgaaaaaa ccgttcccgc cgcggcctga aaaagatatc 965881 ctgcttttta tcgaggagca ttcccgggag ctggagccat ggcagcgtga tatattaacg 965941 atgatgagag aggaaatgct ttatttctgg cctcagctgg aaaccaagat tatgaatgag 966001 ggctgggctt cctattggca ccagagaatt atacgtgagc ttgatttaac ctctgatgaa 966061 gcgatcgagt tcgccaagct gaatgcaggt gtcgttcagc cgtccaaaac aggcattaat 966121 ccttattatt tagggctgaa aatatttgaa gacattgaaa agaggtacaa caacccgacg 966181 gaggaaatga agaaaatggg cgtgcagcct gactccggcc gggagaaaat gtttgaggtc 966241 agggagattg aatccgatat ctctttcatc cgcaattatt taaccaaaga attagtcatg 966301 cgcgaggatc tttatttgtt tcaaaaacag ggccgagatt ataaaatcat cgataaacag 966361 tggaagtcgg tgcgcgacca gctcgtaagc atgcgggtaa atggcggttt tccatatttg 966421 acagtaaacg acggcgatta tatgaaaaat aacgaactct atattaagca ttggtatgag 966481 ggcatagagt tggatttgaa atatttggag aaagtgcttc cttatttatt ccagctttgg 966541 ggaagaagcg tgcacattga gtctgtgctt gaggataagg aagtcatgtt ttcgtacgac 966601 ggaaaaggtg ttcaccgcag atatttataa aaaagaggat gcagcgttct gcatcctttt 966661 tattttccag tttttaaaat cttaaatatg atgtttgcct ggtccgtatt gttaatcaat 966721 ccgcggaatt tttcttttcc ggggccgtac gcgtataccg gtacttcttc gccggtatga 966781 tcggtactcg tccatccgct gttggagcgg gtattaaaaa tcttgatgat ggctttggag 966841 gcccctttgc ttttgtcagc ctgtgcagct gcttcaacgc ttttgatttc ttcagatgtg 966901 actttcagat tggcatagcg ggcgagcaca tctttaaccg gcttgccttc actgattttt 966961 ttggccatga attcaggtgt tttcttagcg gagagaatcg gttctgcgtg ccaattcttt 967021 tccccgtttg cgccaatggt aaagccgccg gttgtatggt cagcagttgc aatcacaagt 967081 gtatgtttgt cttttttcgc aaattcaatc gcggctttat aggcctgttc aaaatcttta 967141 acctcgctca tggctcctac tgtatcattg tcatgggccg cccagtcaat ctggctccct 967201 tcgaccatca agaaaaatcc ttttttattt tggttcaggc gatcaattgc tgaaaccgtc 967261 atgtctttga gagacggtgt tttactgtca cggtcgagcg ctttagcaag ccctccatct 967321 gcgaaaagcc cgagcacctg ctgatcttta ttttttttca atgcttgttt agttgtcaca 967381 tagctgtagc cggcttgttt gaattccttt gtcaagtttc tgtccttgcg gttaaaataa 967441 gattttccgc cgccgagcag cacgtctatt ttatgtttgc cttttatctt gtcatccata 967501 tagctgttgg cgatttggtc catgtttttc cgtgattcat tgtgggcgcc atatgcggct 967561 ggagtggcgt ggttaatttc agacgtggcg acaagccctg ttgacttgcc ttgctgtttg 967621 gcctcttcaa gtacagattt cacttttttt ccgtttttat cgacgccaat tgcattgtta 967681 tatgtcttaa cgcctgtcgc taatgctgtt ccggctgctg ctgaatctgt aatattatag 967741 tcagggtcat ccggatgcgt catcatcatg cctgtcaggt tccggtcaaa ttctgttaac 967801 ttcgggttat tcggtgtgtc accgttattt ttcatggaac ggtaggctct tatgtaaggc 967861 gtccccatgc cgtcgcctat catcacaatg acatttctga tctcagcttt gtcttgtttt 967921 ttggcgctgg ccttttctgt ttgctgaagc tcagctccgg caaagattcc agctgtaagg 967981 acagaaacag cggcgattgg cagaagtttt gatttcatat tttgaaacaa actcattttt 968041 ttcatgcctc ctttaatgta ttccgtttat catgttaggg aaactttgtt aaatgcggct 968101 gttgatcatg taaacaataa gtaaagcctt gtaaggaaat gaaaaaacgc ttttcgttat 968161 cttgccttat ttgatgtaaa gcattcattt ttcagaaaaa tctttacctc tctgtctttg 968221 catgatatgt ttgtttaaat aaaaaaactg cggataacca cagctctcct cgaatatact 968281 ttatcactca tttttccgat atatgagccg accccgaaag tttttcattt atttccttta 968341 tgttgaaaaa catcccataa aacatgacaa aagcactcgt tttttgtcac ctttgcaatg 968401 aaaatgaaat atttaatacc cttaaaaact tttttttaga acgaataatt aagaaatttg 968461 tcacatgaag tcaagactat ttctgatggg aatctatcct tataatagaa atcaataaga 968521 ttaatttaaa aaaagagata catatatata gagttaacat ttggggagga aaatatgaaa 968581 aagcaaatca ttacagctac gacagcagtt gttttaggat cgacgttatt tgcaggagcg 968641 gcatctgcac aaagcattaa ggtgaaaaaa ggcgacacgt tatgggatct ttcaagaaaa 968701 tacgacacaa cgatcagtaa aattaaatca gagaaccacc ttcgttcaga cattatttat 968761 gtgggacaaa ctttatcgat taacggcaaa tctacaagtt caaaaagcag cagttcttct 968821 tcctcttctt ctacatacaa agtaaagagc ggggacagcc tttggaaaat ttcaaaaaaa 968881 tacggcatga caatcaatga actgaagaag ctgaatggct taaaatcaga tttgcttcgt 968941 gttggacaag tcctgaaact gaaaggttca actagttcaa gcagctccag ctcatcaaaa 969001 gtgtcatcgt cttcaacttc tacttataaa gtgaagagcg gagacagcct ttctaaaatt 969061 gcgagcaaat acggcactac ggttagcaaa ttaaaaagct taaacggctt aaaatcagat 969121 gtaatctatg tcaaccaagt attgaaggtg aaaggaacaa gcacaagcag ctcaaaacct 969181 gcttcatctt catcgtcttc aagcagcaaa acgtcatcta catcacttaa tgtgagcaag 969241 ctggtttctg atgcaaaagc gttagtcgga acgccatata aatggggcgg aacgacaact 969301 tcaggctttg actgcagcgg attcatttgg tacgtactga ataaacaaac aagtgtgggc 969361 agaacaagca ctgcaggata ctggagttct atgaagagca ttgccagccc gtctgttggt 969421 gatttcgtct tcttcacaac atataaatcc ggcccttctc acatggggat ttacattgga 969481 aacaacagtt tcattcatgc aggatctgac ggcgtacaaa tcagcagcct gaacaacagc 969541 tactggaagc ctcgttacct cggtgcgaaa agattctaat ttttagagaa aacccgttca 969601 ttggaacggg tttttttcat tagacggagc acaggcgttt tggttgctcc taaaaatgaa 969661 aatgtgataa aaaatccaag aacttttttt ctttcttatt ttcataaagg gcaatcgcgt 969721 aagcgccggc atagggcagc tgtacagact gataaggaat tctgatcatc tgtttctctg 969781 ctaactcacg ctttactgta gataaaggca gaaatgaaac tccgagtcct tccttgataa 969841 accgtttcgt tatatgtgtt tgagtgacct tcattgttct cacaaatgga aatgtcattc 969901 tgacttgacg gagcaagtcg tcccagtaat caggatgatt gtgggtcaaa agcaggtatt 969961 gttcgagcac ctctttggca tcaatttcgt tgtcttctat gaaacgctta tcgggcgggg 970021 caacaaggac gacagggtct ttgtataagc agtggcagct taaagaagaa gactgtacct 970081 ttaaacagct tagtccgata tctgcttccc cggctttaat cagtgacgcg atttccgctg 970141 attcgaaaat cgtaaccgcc atttctgttt ccgtattcat tgctgtgtac cgcttcatga 970201 cagaaggaag cactgtatct gcaataagcg gagaaaccgc gagctgtaag gtttgagagt 970261 agccttgtct cactctgtga agctctgcca tgctgttttc ataatcatca agaagcctga 970321 gcgcatacgg caaatacgcc ctgccttcat cagtcagctg gatttgcctg cctttacgct 970381 cgaacagctt gcagctgatt tctttttcta attgcttgat atgtacggtc acagtaggct 970441 gagataagaa aagcgtttcc gccgtttttc ggaagttctc atattttgca gcggtcacaa 970501 aggtgtgaag ccatttgaaa tccatttcta ttctccctct gattaatatt tttaattaat 970561 tccctttaaa atattgatta ttttttaaat attatattta ctataataac agaaaaggat 970621 agggggaata caaatggtac attacggatt aaagggaatt acatgtgtag aaacatccat 970681 cagccatatt gatggtgaaa aagggcgtct gatttacaga ggacatcatg caaaagacat 970741 cgcactgaat cacagctttg aagaagcggc ttatttgatt ttatttggaa aactgccttc 970801 aactgaagaa ttgcaggtat ttaaagataa gctggctgcg gaacggaatc ttccggaaca 970861 tattgagcgc ttgattcaat cactgccaaa caacatggac gatatgtcgg tgctgagaac 970921 ggttgtttca gcattggggg aaaatacgta cacattccat ccgaaaacag aggaagcaat 970981 ccggctgatt gcaatcacgc cttctatcat tgcatacaga aaaagatgga cgcgcggtga 971041 acaagcaatt gcaccttctt cccagtacgg acatgtcgaa aactactatt atatgctcac 971101 aggtgaacag ccttcagagg caaaaaagaa agcgcttgaa acctatatga ttctggccac 971161 ggagcacggc atgaacgcat cgactttttc ggcacgagtc acgttatcta cagagagtga 971221 tttagtgtca gccgtcacgg ctgctctcgg tacgatgaaa ggtccgctgc acggaggtgc 971281 tccttctgcg gtgacaaaaa tgcttgaaga cattggagaa aaggaacatg ctgaagcata 971341 tctgaaagaa aaactcgaaa aaggagagcg cttgatggga ttcggccaca gggtgtacaa 971401 aacaaaagac ccgcgggcag aagctttgag acagaaagca gaagaggtgg ccggcaatga 971461 ccgtgatctt gatcttgcgc tgcatgtaga agcagaagcg attcgtttgc tagaaatcta 971521 caaaccggga cgaaagctgt acacaaatgt tgaattttac gcagctgcag tgatgagggc 971581 catcgatttt gacgatgaat tgtttactcc gaccttttca gcaagccgaa tggtagggtg 971641 gtgcgcccat gtactggaac aggcagaaaa caacatgatt ttccgcccgt cagcgcaata 971701 taccggtgcc attcccgagg aagttctttc ataacatatt ttggcgttta ttcatttctg 971761 tcgtgtggta acgttcagta tcaaccacat gtctaggagt gatgaatgtg aacccaatgg 971821 acagacaaac agaaggacaa gaaccgcagc atcaggacag acagccgggc attgagtcaa 971881 aaatgaatcc gctgccgctg tcagaggacg aggattatcg aggaagcgga aaactgaaag 971941 gaaaagttgc gatcattact ggaggcgaca gcggaatagg gagagcagca gctattgcct 972001 ttgctaaaga gggggctgat atctccattc tatacttaga cgagcattcg gacgcagagg 972061 aaacacgcaa acggatcgaa aaggagaatg tccgctgcct gcttatcccg ggagatgttg 972121 gggacgagaa ccattgtgaa caagctgtgc agcaaacagt ggaccatttt ggtaaactcg 972181 atatcttagt gaacaacgcc gctgaacagc atccccagga cagcattctc aatatttcaa 972241 cagaacagct ggaaaaaacc tttcgcacaa atattttttc catgtttcat atgacgaaga 972301 aagctttgcc tcacctgcaa gaggggtgtg ccattattaa tacgacatcg attaccgctt 972361 atgaagggga tacggcgtta attgattatt ccagcacaaa gggtgcgatt gtttccttta 972421 cgcgttccat ggcgaagtcg cttgcagata aaggcatcag agtgaatgcg gtggcgcccg 972481 gtccgatttg gacaccgctt attccggcga cattccctga ggaaaaagtg aaacagcacg 972541 gcttggatac cccaatggga agaccgggac agccggttga gcatgcaggc gcctatgttc 972601 tgctggcgtc tgacgaatct tcctatatga cagggcagac cattcatgtg aatggcggcc 972661 gttttatttc aacgtaatca acgaaaaacc agctcaagag ctggtttttt gtgtggtgaa 972721 aaatttcaaa ataaaaaatt tgtcgatttt tctaacaatt ttgttttcat ttttgcaatt 972781 ttatatataa tattgagtag gagaaaggaa tgattcgcga ccagtacaaa tatagtagaa 972841 aaaaaagaat aatgaccatt gttactcatg aattcagaaa attcaaataa aatatataaa 972901 aatagatgat cgggagttga aggggaatga aagggagcgt ttttaggaag aaaagcattc 972961 aggatttaat cgctgcgacg agcggggaaa agtctttaaa aagagaatta ggggcatttg 973021 atttaacgtt gcttggaatc ggcgccatta ttggcacagg gatttttgtt ctgacgggaa 973081 caggcgcagt cacggccggt cccgggctga cgatttcatt tgttgtggcg gcgttggctt 973141 gtttattcgc cgccctgtct tacgcggaat ttgcgtcaag tgtgcctgtt tcaggttcgg 973201 tgtatacatt cacttatgcg acattgggag agcttatggc ctttattatc gggtgggatt 973261 taattttaga atacatgctg gcggtaagtg cagtgtcggt cggctggtct ggttatttcc 973321 aatcgttttt atcagggctt ggcattcatc ttccggttgc tttaacagcg gcaccgggcg 973381 cagtgaaagg cacctttacc ctgtttaatc ttcctgcatt cgtcattgta atggcgatca 973441 catatttgct ttatttaggc atcaaagaat caaaaagagt caacaatatc atggttatct 973501 tgaagatact ggttgttctg ctgtttatcg cggtggcagc cgtttacgtg aagccgcaca 973561 actggcagcc gtttatgcca atgggctttg gcggcgtgtt cagtgcagcg gcgctcgtat 973621 tctttgcttt tatcggattt gacgctgtat cctctgctgc ggaagaaacg aaaaatcccg 973681 cgaaggatct gcctaaaggc attattttct ctttactggt ctgcacgatt ttatatgtca 973741 ccgtatcagc catcatgact ggggttatcc cgtttgctca atttgcgggt gtggatcatc 973801 cggtttctct tgttcttcaa agcgcagggc aaaattgggt ggcaggcatc attgatattg 973861 gcgccgtgtt gggaatgaca acagttatgc tcgtgatgct ttacgggcag acccgcgtca 973921 tgtttgccat gtcgcgtgac ggacttgtgc cgggttcact ttctaaagtg catccaaagc 973981 acaaaacacc ttatgtagcc acttggtttt tcggaacgat gtcggcgctt ctcggctcac 974041 ttgttccgct ggatgaactt gcaaagctgg tgaacatcgg gacgttgtcg gcatttgtcc 974101 tgatttctgt ggcagttatc gttttgagaa agaaacagcc tgatcttccg agagctttta 974161 aatgcccggg agttcccgtg atcccaggcc tggcgattct gttctgcctg ttcttgattt 974221 taaatctggg atgggtgacg attgtccgct tcctagtgtg gctgttaatc ggcttggtaa 974281 tctatttcct gtattcaaga aagcattcaa aattaaatca ataacctttt gataaagaga 974341 gcggccatac aggccgcctc ttttctgttc ttggcaaatg aatctataga aatgaagaca 974401 aaaataagag ataatatagg ctggaaagga agtgacgttt attgtctgag caaaaaccag 974461 tccaatgggc ttcgaaaatt ggtttcgtca tggcagcggc cggctcggct atcggcttgg 974521 gcgcgatttg gaagttccct tacgtagcgg ggaccaatgg gggaggagcc ttttttctta 974581 tcttcgtgtt atttaccatc ctcttaggct atccgctttt ggtgggggaa tttatttttg 974641 gaagacggaa ccagacgaat gccattgatg catataaaaa agaagcgccg cgatcagctt 974701 ggtttcttac ggggtggatc ggcgtagcgg cgtgtttctt agtgctgtcg ttttacagtg 974761 taatcggggg atggattttg ctgtatatcg tgaaaacagc gtcaggatca ctgtccgggc 974821 tttctcaagc acagtatggc gctctttttg cttctattat ccaaaatccg gtgcagacgc 974881 tcgcggctca gcttgtcttt atggcactga ctgtactcgt tgtcgcaaga ggggttcaaa 974941 aagggattga acgggtaagc gcggtgatga tgccgatttt gtttttattg tttattctgc 975001 tcgttcttcg gtctcttacg cttaatggtg caatggaagg cgtaaagttt ctgcttgtgc 975061 ctcatttcgg cgatctgact ccggaatcca tattattcgc gctgggacag gccttcttta 975121 cgttaacact gggggtttcg gtgatggtga cctacagctc ctatttgccg aaaacacaaa 975181 atatccctcg ttcggcagcc tccattgtct tgatgaatat cattgtgaca ctcttggcag 975241 gtttggctat ttttccggcg gttttctcat tcggttttca gccaaatgaa ggaccgacat 975301 tgctgtttac agtgcttccg gccgtttttg aacagcttcc gttcggcaca ttgtttttta 975361 tcggctttct cgttgcattt ttatttgcag ccttaacctc agcattttcg atggttgaaa 975421 ttatcgttgc cacaatcgga aaaggggacg aaaagaagag aaaaaaactg tcatggacga 975481 gcgggctttt gatctttttg gtcggaatcc catgctgctt gtcttatggc gttttgagtg 975541 atgtgcacct atttggcaaa acgttttttg atattgccga ttttaccgtc agcaatgttt 975601 tgatgccttc aggcgctctg ttaatttctc tatttatccc gctgaaaatt tcgaaaagcg 975661 aactcttggc tgaaatgcga aatggatcaa atgcaggtaa agcattcttt tacacatggt 975721 tttatttgct tcgttttatc gtgccgcttg ccattattat cgtgttctta aatttaatcg 975781 gaattttatc attttaaaaa acaggctccg tttccggggc ctgtttttta tttaataaga 975841 tgatatcaac ggtgcccatg ccgttttcag tttttggatg ccgagcctga tgtcctcttc 975901 tgacaaaccg ccataaccga ttaagacaga agtaaaaggc gtctgttcta tatatgaggg 975961 agacacggga tagagggtta caccgtggtc agcggctgct tgtattgctt cttcctcact 976021 tgctggaaac aaaaggcgca gcagaatgtg aagccccgag ttcttaccga gaatctcaac 976081 ggtgtttccc agttcagagc gaatggcttc taacaggaca gcgtgttttt ttcggtataa 976141 gcttctcatt ctatttatgt gtttttgcca ctctccggtt tcgatgaagt ctgccagtgc 976201 caattgcgag tgggcagaaa cggtctgctt cattaactga acattgtttt ggatcggttc 976261 catgagttca gggggcacaa tcatgaagct gagccgcaag gaaggcagaa gtgactttga 976321 aaaagtgccc agatatatga ctctgccatt cggatcaaga ccctgtaaag acggaatggg 976381 atggccgctg tagcgaaatt ctccatcgta atcatcttct ataatgaatg aatttgtttc 976441 tgccgcccat gccagcagct cctgtctgcg ggtaatcgtc ataatggtcc caatcggaaa 976501 ctgatgcgaa ggagtcgtat acatgagata aggattctga cggtagagct catccggcag 976561 gacgccttct gcatcagaac aaatcggagt gacatccatg tgatttgctt caaacatcct 976621 tcttgaacgg tgaaagcccg gttcttcaaa gccgattttt gtacctggct ttagcgaaag 976681 gcaaagattt tgcagaagca cggtggttcc tgcgccgatg ataatctggc cgggttcaca 976741 atttactccc cgagacagcc tgacgaatcg ggcaatcatg tgcctgagtt cgtattctcc 976801 ttgagggtcg ccagaggtgt gaaacgatcc ggaatagcga tcaagacttt ttactatgct 976861 ttttctccat gcgttaaagg gaaagagggt cggatcaacg ctgccctgat ggaagtcaat 976921 agcaggtgcg tttttttgat gtaatcccgg ctgtacagac tgctgaaaat ggtcaggagc 976981 tgtcgggaat cctggttcta cttccgccgc gaaccagccg attttcggct tgcttttgac 977041 atagccctca gcagttaatt gctcataagc tcgttctata gttgccgtgc tgacatcgag 977101 caagctggag agcctgcgtt ttgacggaag tcttgttccc tttgtgattc gcgcatgtga 977161 aatttcttgt ttaaaaaagg tataaagctg ttcatacagc ggtgttttgc tctttttatc 977221 aagaaacggc gtaatatcca tctcatgtct cctttgtagc tggcatggtc attttttctg 977281 atattggcta tttggcaaat gccatttatt agctatgatc attgtaacga aaggaaaggg 977341 gattgagaag atgatccata tgaaacaatt aacctcgaaa gaagaatggg ctgagtcgta 977401 tccgattatg agtgaattga gaacagaact ggatatagag acgtatttac aaaggcttga 977461 agcctgtgtg cagaaagaat cgtatatgct gtttgcctta tatgaaaata cagcaatcag 977521 agcgctgtgc ggggctctgc cgagagtttc cattcataaa ggagagcact tgtggattgc 977581 ggatcttgtt acaacggcac cttgccgatc aaagggatac ggcaaaatgc ttttggatta 977641 tgcctcagac tgggcgagaa aagccggact cggttttgtc agtctttcat ctggccttca 977701 gcgtaaagac gcacatcgat tttatacaga taaaatgggt tttactatag aaagttattt 977761 gttccgaaaa ccggtataac gaaaaaagac gcctgaaaag gcgtcttttt taaaagccaa 977821 actgtaaatt cgtatctaca gatacaatgg tatacacaca aataatcaca aagagattaa 977881 ggatgacgcc gagcaggcct ggacctgtgc gccctctctt gatgaagagt tcaacaacgc 977941 cgaacggaac ggcagccatg gcgaacggaa gcatttgata ggaataaaac gtgacgttgc 978001 tgataatggc caaattcagc aacagcaggg acagaaccgc tgtcccgaca gagatccagc 978061 cgaatacatt gtgttcttta aaaattctta ccagttccat aattccacct cgccgacatt 978121 cgctgatttt acagatttat ttttcagcat gcgctggatt tccttggttg gccctgtaac 978181 gaccgaaccg tatacattga caccgttttt ctctacataa tctaatcggt tatctacatt 978241 caggtctttc cgttttgaaa tgacctgagc ccatttttcg tgtttggaca tgaatttcag 978301 ggcgttgata aactgatcgc cattcgactt gccttttgta ttaagggcgg ccaagaactt 978361 tgaatccttt ccaggatagc caagaggttc tgtggaagct gtcttatttg tgtttttctc 978421 tgtttcgatt gcgttccaca aaaagctcac atcatagcct ttgaatttgt tatacacgtc 978481 ttttgtcgga tatgcacggt catatgaaag gtagacctct gataccgttc cttcaggcaa 978541 tgtgcttaac gttttttctg cttttgcggt cgtttgttca gacttgtttg aaggatgtgt 978601 aaagtaatgg ccggttttat tcacttctaa gtcatagtag tttactgccg gcgcttttac 978661 tttgttataa aacatttcaa cccgttcatt ccctacggca gccgtcttcg tgccaatctg 978721 cttttgcagc gggaattccg tattcattcc aaatagcttc acttggcttt tcagtccgga 978781 agtatcaaca agaacattcg gcatggtcag ggctacagtg actgcggcag tttccataaa 978841 ctcattgccg gtgctgtgtt ttccacccat tccgtaatag aggtagcttc ccagcgtaca 978901 aagcggcaaa atcatcaatg tcgaaatgac ggcaagcaca gaaattcgca aataagactt 978961 gcgtttgccg taggctaaaa tcgctttttg tttttcagga ctgatgctga gatcccaatc 979021 gttatcgtcc tctagttcgc tgtcaatcag ttcctgatat acttcaagct tctcgagttc 979081 ttcctcaaat gcagtcattt cctggtcgct catttcccca tttttatatt gatcaaaacg 979141 ctttttaaat tcttcattca tcattaacac ctctattata aagtgctttc agccgctgtc 979201 tggcacgaaa taaaacactt ttaaaattcg cctctgaaat attcataata tgggatgctt 979261 ctttgtagtt taactctttt aaataatata gcgttaaggc ctcccgataa ttatcgggga 979321 gctcggacat ataaccagtc agcacttcct ttatctctac ctgatgggca ggactttgaa 979381 cagcattttg aaagaggctt ccgattaagt catcagaaat ggttacttct ttcttatgct 979441 ttctgacgta atcaatgaag gcgtttcgcg ccacttgaaa aagccagggc tttactttgc 979501 tgtgatcata ggagtgaatg tgtatgtatg cccgcataaa ggtttcctgc agtaagtctt 979561 cagcaagatg cttgtctttt gtcatggaga gcaggaacct gtaaacatca ttcatgtaca 979621 tttggtaaat ttcatcgatc gtcactgcct tttctcccct ctatgttata cacgcataag 979681 aaaggtttaa agttgcacat tacatgcaaa cggctttttt atacctaatc aaacaccatt 979741 actatatagt acccaaaaat ggccgcaaaa gatagtgcgg agaaaggttt aacatttttt 979801 ccagagggga aaagatagtg aaaaagtgaa ggagtggcac aatggaatat accagtatag 979861 cagatacagg aatagaagcc tccagaatcg gcctcggcac atgggccatt ggcggaacga 979921 tgtggggagg cactgacgaa aaaacatcga ttgaaacaat ccgcgccgct cttgatcagg 979981 ggattacact gattgacacc gcaccggctt acggcttcgg gcagtccgag gaaattgtcg 980041 gaaaggcaat caaagagtac ggcaaaagag accaggtgat tctcgcaacg aaaacggctc 980101 tggactggaa gaacaaccag ctgttccgcc atgcgaacag agcgagaatt gtagaggaag 980161 ttgagaattc tttgaagcgg cttcaaacag actatattga tctttatcag gtgcattggc 980221 ccgatccgct tgtgccaatt gaagaaacgg ctgaagtcat gaaggaatta tatgatgcgg 980281 gaaaaatccg ggcgattggc gtcagcaatt tttcaattga gcaaatggat acatttcgcg 980341 ccgtcgcacc tctccatacg attcagcctc catataatct gtttgaaaga gagatggaag 980401 agagtgtcct tccttatgcg aaagataaca agataacaac attattatac ggcagtttat 980461 gcagagggct gttaacaggc aaaatgactg aagaatatac atttgagggc gatgatctgc 980521 gtaatcacga tccaaaattc cagaagcccc gctttaaaga gtatctttct gctgtgaatc 980581 aattggataa gctggcgaag acacgttatg gaaaatcagt gattcacttg gctgtcagat 980641 ggatcttaga tcagccggga gcggatatcg ctctttgggg agcaagaaag cctgggcagc 980701 ttgaggccct atctgagatt acaggctgga cgctgaacag tgaagatcag aaagatatca 980761 atactatatt ggaaaatacg atatcagacc ctgtcggacc ggagtttatg gccccgccga 980821 ccagagagga aatataacaa aagctgaggg cgaatcctca gctttttggc gtttaaacga 980881 gagaaatctt aaaaattagt accaggtaat aaaaaatatt gttataatag atgacagaaa 980941 gaatcattga ttacgacaaa ggaagtgcga tatgtataag ttttgtgcaa atgctttaaa 981001 agttattctt tctcttcgcg gaggagtgaa ggtgtataac aaagaaaacc ttccggccga 981061 ttcaggtttt gtcatcgcgt gtacacattc cggctgggtt gatgtgatta cactcggagt 981121 cgggattctt ccttatcaaa tacactacat ggcgaaaaaa gagctttttc aaaataaatg 981181 gatcggttcg tttctgaaga aaattcatgc ctttccggta gatcgggaaa atcccgggcc 981241 aagcagtatt aaaacgccga ttaagctgct gaaagaagga gagatcgtcg gtatcttccc 981301 aagcggaaca agaacctctg aggatgtgcc tttgaaaaga ggtgcggtga cgattgcgca 981361 aatggggaaa gcgccgcttg tccccgctgc atatcagggc ccttcaagcg gaaaagaatt 981421 attcaaaaaa ggaaaaatga agctgattat cggtgagcct cttcaccagg ctgattttgc 981481 ccacctgcct tcaaaggaaa gacttgcagc aatgacagag gctttgaatc agcggattaa 981541 agaactagag aataaacttg atcagctata aggcgttctg agagattgtc ctgaaactgt 981601 gaaaataaga aaagcaccct atacaaggtg cttttcttat tatgcttcct gctggttagc 981661 tgtctccaga agttcttctt cttgaagctt tttcacttca atatatgcga cgtggtggcc 981721 gtcaatttca ttaatgatga attcgcagcc ctcttcgatg atggaatcat ctttttcaac 981781 atcgtatttt tgagtaagga accagccgcc gattgtatcg acttcttcgt tctctaaatg 981841 gatgcctagc aggtcgttta cttggtcaat taacactttt ccgtcaagaa tataatggcc 981901 ttcgccgatt ttgcggattt cgctaatttc atcaatatca aattcgtcgc ggatttcacc 981961 gacaatttcc tcaatgatgt cctcaaccgt cacaagcccg gcagtaccgc cgtattcatc 982021 agacaaaatg gccatgtgga ccctctcttt ttgcattttg acaagcaggt cttggatcgg 982081 cgcagattca atgacatgaa tgatagggtt gacgaattga gaaatggtgg aatcaacaga 982141 tacctcaccg ctgatgcagg cggtcagcac ttctttaatg ttaataaccc cgataatgtt 982201 atctttatcg ccctcttcca cagggtagcg ggtatatttt tcaatctgaa tgatgtccat 982261 catttcagaa atcttgatat catgcggaag gctgacaatt tcggtccgcg gaatcataat 982321 ttctttcgcg agcctgtcgt caaattcaaa gattttattc acatatttaa actctgattg 982381 gttgatttca ccgcttttat agctttcaga caaaatgatt cgcagctctt cttctgagtg 982441 agccagttcg ttttctgaaa cggtctccag gccaaatgct ttggtcaata accgtgcgga 982501 attgttcaaa agccaaatga atgggaacgc gatgcggtaa aaccaaatca gcggtttcgc 982561 aaacagcata gacactgctt ccgccttttg gatagcgact gttttaggtg caagttctcc 982621 gacaacaacg tgtaagaacg tgataatggc atacgcaaaa ataaacgata tgacatgtga 982681 aagggaacct ggaacgttca tttggacgaa aagcgggtga agcagccttt cgatcgttga 982741 ttcacctaaa acccctaatc cgatggaagt caatgtaatt ccgagctgac acgcagataa 982801 atattcatca agatgcgtgg tcactttttt tacggctatt gctgctttat ttccttccgc 982861 gatcagctga tcgatccgtg agcctctgat tctgataatg gcaaactcag atgccacgaa 982921 aaatgccgtc agggcgatta aaacagcaac taaaatcaaa ttcactatgt ccaattagaa 982981 ccttcactct agcaatgaga atgaaggtaa cacctcctgt tagataaaat ggttttaact 983041 taacagcagc ataaatgatt ggaacacggc gagcttttca ggcgggagtt tgcttttcag 983101 cttgtcacga tcctcgggct tcagccgttc aaaccgatgc aagattccgg agatgttttg 983161 attcatatga tcaatttcta atgccagatt tccaatttca tcatcaagtt tagctgaaga 983221 gggaaactgg ttctccagtc gatctttaat atcggacagg gccaatcgct gcttcttgca 983281 atctacaata aatataagtc gtttgagtgc attttcgtcg tagtaacggt aatttgaaca 983341 ggatctggcc ggcgtaagca gaccgagatt cgtataataa tcaactgtcc gtttcgttac 983401 tccggcgagt gccgctagtt cactgatgcg ataagtctca gccccatcta tatccctccc 983461 aaccatcacg ttatagttat gagaatagtt taatatatga acggtgtctt gcacaagttt 983521 attgtttttt ttagaccgga attggaagtt gtggaattca tcatctgatt gaagtaacat 983581 aggaagatag aattttcaaa tttttatatg cggaagggac agatgaaatt ggctgggtta 983641 tcccgggaag ttgaagaaaa cttaaataaa ggatcatgga ttcgcaagct gtttgatgaa 983701 ggtgcaaggc tgaagaagga gttcggggaa gaccaggtat ttgatttttc actcggcaac 983761 ccgattgttg aaccgcctga agcttttaag agagcgttaa tagaggaagc tgaaaaaggc 983821 agccacggat acatacaaaa ccaagggctt cttgcagcga gagaaaaagt cgcgcaattt 983881 ctgggctcgc gttttgaagc tgatttctca gcggagcgca tcgtcatgac ggtgggcgcg 983941 ggaggcgctt tgaatgttgc gttaaaaagc atcgtaaacc ctggggaaga ggtcattatt 984001 cttgcacctt attttgccga atataagttg tatattgaga actacggggg aaaagccgtc 984061 agctgcccgt tgacaagccg gtttgagatc gacattgaag cggtaaggca atcgatcact 984121 ccacagacga aagggctgat tctcaataca ccgcataacc ccacaggcac tgttctcagc 984181 cagaaaaata tagacgattt aggcgcttta ttaaaagaaa tagaagagaa gagcggccag 984241 acgatttatg tgctgtttga tgaaccgtac agtcaattaa tctatgatga agagctggca 984301 aatccgtttc aatcgtacca tcgtgtgata ttggccagct cattcagtaa agatctcggc 984361 atagccggag agcggctcgg gtatatcgga ttggacagcc gaatgccgga tgcggacctt 984421 ttgatcaacg cttttgtgta ttgtaatcga acgcttggat ttgtgaatgc ccctgtcatg 984481 atgcagcggg ctgtggcacg aatggatgat ttaagagtag acgcgagcgc ttataaagag 984541 cgccgggatt taatggtaga cattttaaaa gaagccggtt ttgaatttga aatgccaaag 984601 ggaggtttct ttgtttttcc gaaatcgccg attgaagatg aagttgcatt ttgcgtgcat 984661 gccgcccaaa aatacaaatt attaattgtg ccgagcagcg gttttggaat gagcgggcat 984721 ttccgattat ccttcagtgt gccgatcgag cagattaaaa actcacggga cattttcatt 984781 tctttatata aagattttgc ttaagaaggc aaagaaaaga aaacagtttt caaggctgtt 984841 ttctttttat atccgcaaaa tccttcctct tccaatccag acaggcgcag aattgacaag 984901 caggcatgca gttaaggctt tcttcatgat aaaagtctaa aaattaaaaa tcatttttgg 984961 aatgagttgt gttacaataa aatatacaat ttataatcaa actttgactt ttggaggtgg 985021 tatgatgggg ccctctgctt aggcaacaat acaccgcgta cctcaatgtt aaggaaaaat 985081 gattatatca ggaggtgact ccttatcctt tgttgagagg atagggttaa atggacgata 985141 ttgacagtct gattttaatt ggcgtgctca ttgctttaac cgcgtttttc gttgcaagcg 985201 agtttgcgat tgttagagtg aggagatcca gaatagatca gcttatcaca gaaggaaaca 985261 aacgggcgat actcgcaagg cgtgtcatta cagatttgga tgaatattta tccgcatccc 985321 agctaggcat tacattgaca tcaatcgggc ttggcgtact gggtgagccg gcctttgaac 985381 ggctgctgca tccactgttt gaaccgctcg gcttgccgga ctcggtttca catgcagtct 985441 cttttgcagt cgcgtacggc ttgatcacgt tcctgcacgt tgttgtaggt gaactggccc 985501 cgaaaacggt cgcgattcaa aaggcagaac agctgacttt actgatagcg ggccctttgc 985561 gtttattcta tttgctcctg tttccgttta tttggatcct caatggatcg gcgcggcttt 985621 tatgcgggat gttcggtttg aagcctgcgt cagaacatga tggttcccat tctgaggaag 985681 aactcaggat gctgttatct gagagtttaa aaaacggaga gattaatccg tctgaatata 985741 aatatgtgaa taagattttt gaatttgata atcggatcgc caaagaaatt atgataccgc 985801 ggaaggaaat ggctgctgtg tcaactgaga tgacgatggc cgagatgctt gaagtcatgc 985861 tgaaggaaaa atacacgcgc tggccagtca cagatggaga caaagacagt gtgctcggtt 985921 tggtcaatac gaagcatttg ttttctgatt tgctgtttat gacagaagaa gaacgaatga 985981 agatgacgat ccatccgtat gtgaggccgg tcatcgaagt gattgaaacg atcccggttc 986041 atgacttgct gattaaaatg cagcgcgagc gcattcatat ggctatattg tcggatgaat 986101 acggaggaac ctcgggactt gtgacgacag aggatattct tgaggaaatt gtcggagaga 986161 tccgagatga atttgatgaa gatgaacagc cgctgatcca aaagcttggc gacggccatt 986221 atgtgatgga tggaaaggtt cggatcgatc aggtgaacag ccttcttggc gcatcgattc 986281 aagaagacgt cgatacgatc ggcgggctga tattaaaaga aaacatcgat attgaggctg 986341 gtgaatccat tcgcatcggt tcatatacga taaaggtgct gaagatggac ggccgattaa 986401 tcaagcaaat cgatataaaa gaagaagccg gcaacacaac cgggattacg gcgcaccaca 986461 agctgccgct gcccgagcct gtgatgctga acagtgcaac cttgagcgag aaataagctc 986521 aaggtttttt tatattgtga ttgtccagcc gcaccaaaat gcaaaaagcg acccgcaaag 986581 tgtcaggacg atgtacaaga tgctttcttt tacacgtttg gccataagga gttgaatagt 986641 ttcaacgctg aatgtggaaa aggtcgtaaa ggcgccaaaa aaccccgtgc caatgataag 986701 cgagaccgaa gcatttgcaa cgtgaagtcc tgtaaatatt ccgagcccga gagctccgag 986761 aatattgact gtcagtatgc caatgggcag gctgagacct ttggttttgg cggttatgac 986821 attgccaagc cagaagcgaa gcattgcgcc aagtccgccc cctatgaaaa tacccgctag 986881 tgtcattttt cctgcagccc ctttctttgc tgaatgcctg ctatgcgccg tcccacaaaa 986941 acaccaatca gtgcaaatat gatccctgat atcaatgagg ctgccacata taaaagagcc 987001 aatgagggtt gtccttgcaa aagcatcact gtttccttag aaaacgtgga cattgttgtg 987061 aagcctccgc aaaagccggt gcctaaaaaa gccgacagca gaggccgttt tgccccgatc 987121 ataaaaaatc cggtcaaaat gcctaataga aggctgcctg ccgcattttc cagccaggtt 987181 gccgccggga actgaccggt gtgtatccat aagtttaatc cgtatcggag gcaggcgcca 987241 agcgcgcctc cgataaaaac cgcgctatat attttcatgt ttgccatcct ttatgatgaa 987301 atccgggtaa tctgtaacga tgccgtccac gcccatggct tgtaattttg ccgctgtctt 987361 ttgattgttg acagtccatg caaatatgtt taagccattt ttattgatgg agccgatcat 987421 cagacggtta agccgtgtgt gttttatatt gacatagttt gcaaaagagc ggaaggcctt 987481 catctgattt ctggacagca tgccaaagtt gggccttgta atgaccgctg tcggaatcga 987541 aggataaagc tcgcggaacc tttggacgga gcggaactga aaggattgaa caatattatt 987601 gatagaaaaa gaaaattgcc ctaatagctg tcccacctct tcttcaattc cgacttgaga 987661 cggatggcct tttagttcaa ttaaaaggcc gatttttttg tggtagcgct tgagcaccgc 987721 ttccagggtt ggaatacgct ctccttgaaa agcgggaccg taccagcttc ctgcatcgag 987781 tttttgcaat tcctccaagg taaaatcctt aacaaagccc gatccgtttg ttgttcggtc 987841 aaccctgtca tcgtgtatca caacaatctg cctgtctttt gtaagctgga catccagttc 987901 gatcatatct gcattcattt tcaccgcaag gtcaaatgcg gcaatcgtat tttccggagc 987961 gtagccggat gctccgcgat gggcaatgat gtacaagcta agtcagctcc tcgtatgggc 988021 atttctgtta ttgtatcaaa tccatatatg caccgcgata caaactggtg aattttttct 988081 gccatatcgg aatggtccgg gctgaggaat gcgtataact aaaaaaagac actcagcgta 988141 tcagaacaca tttcgtcaga aaattaggtc tttcgacatg ttcacaacaa aatatgatcc 988201 tttataatag caaaaaagga ggcgagatca tgggaaaagg gagaatcaga gtggaggaaa 988261 gaattaaagc cgaaacggat gctgaaatgc aaaaagcaac tctccttgat cagacacaaa 988321 cgaaaaaagg taagtgactg tccctattga atctggctga tagatgaatt gagaaatgac 988381 cccggcgttt cgccggggtt ttgtgctgca taagacattt aaatgaacat ccttacgaat 988441 attttagtat aataaacaat tgattgggat agaggggaga cagtcatgcc ggattatctg 988501 cagcagtatt ttacgcttga taacatcata caaatcggca tcagcttggc gattttgctg 988561 gtgtttctta tacttagaaa attattcaca agatattttt ttaacctgct ttttaatttg 988621 acaaaccggc cgaaaacaga aatttttaaa caggtggttc tggcgtttga taagccggcc 988681 agatggtttt ttgttgccct tgggctgttt ttagcgatcc ggtattcacc gtttttagat 988741 gagcaaatgc cggtcatcag caaaatatac cgctcactga ttgtggcgct cttgtgttgg 988801 ggtctttgta atttgaccgc aacatcgtcg tttatcttcc ataaggtgaa ccagcgcttc 988861 gagcttgaca tggatgacat tctggccccg tttttatcca aattgctccg ttttgtgatc 988921 attgcgctca gtgtcagtgt gatcgctcag gaattcaatt atgatgtcaa cggatttgta 988981 gcgggccttg gtcttggcgg actggctttt gcgcttgccg cgaaggatac catcagcaac 989041 ttcttcggcg gtattatcat tattactgaa aagccgttta caattggtga ctgggtggag 989101 acgtcgacag taacaggatc agtcgaggat attaccttta ggagcacgag attcagaaca 989161 gcacaggggg cgcttgtaac ggtgccgaac tctacgctgt cgatggaagc gatcacgaac 989221 tggacaagaa tgaccaaacg ccagattacg ttttccatcc atgtgtccta cgctacgccg 989281 attgagaacc ttgaacgctc cattcattct ctcagaacaa tgctcttaga gcatgagggc 989341 gttgataatg aaataatcat ggtcaacttt gatacgtttg ccgacagcta ctacaattta 989401 ttttttaact tctatacaaa aacgacggtt tgggctgaaa accttaatat tagagaggat 989461 atcaactata aaattattga gattttaggt gcagaaggcg ttcagtttgc atatcccggc 989521 caaatggttg ttgtcaagca aaagcacgaa agcgaccaat tccaggtgaa tctaaataaa 989581 gaggaaaagg aacgggctta aaagagagac ttcgtctgac agaggcggag tctttttcat 989641 ggtaaaataa gagaaaaagg cggtgttgag ttggaaacat tcaaaagtat tctacatgaa 989701 gcacagagaa ttgttgtgct gaccggagcg ggaatgagca cagaatcagg gatccccgac 989761 tttcgttcag cagggggcat ttggacggag gatgcctcaa gaatggaagc gatgagcctt 989821 gattattttt taagttatcc gcgtctgttt tggcccaaat tcaaagaatt gttccagatg 989881 aaaatgagcg gcagctttga accgaatgaa ggccatttgc ttttagctga gctggagaag 989941 caagggaagc aggtcgatat tttcacgcaa aacattgacg gtcttcataa aaaagcgggg 990001 agcaggcatg tgtacgaact gcatggttct atccagacag cagcttgtcc ggcatgcggc 990061 gcccgatatg atcttcccca tttgctggag cgggaggtgc cggagtgcac ggcggccgga 990121 aacaatgggg acatttgcgg aacggtatta aaaaccgatg ttgttctctt tggcgatgcc 990181 gtcatgcact ttgacaccct ttatgaaaag ctggatcaag cagatctttt attggttatc 990241 ggcacgtctc tcgaagtggc tccggctaga tttgtgcctg aggatgcaag cctgattccc 990301 ggcatgaaga aagtcatcat aaaccttgaa ccaacgtatt gcgacagctt gtttgacatg 990361 gtcatccatc aaaaaatcgg cgagtttgcc cgaagtttgg gcatgaaaaa gtgagccgct 990421 ttatgcgcct cactttttta ttcatgaaca ggaaccattg tgtcctctaa cactccgaag 990481 gaatagcctt tttcttttaa tttattgatt agtaccggca gcgcatttac agtagcagga 990541 agatcatgca tgagaattac atttgggcgg cttgaagagc tgtgttccat attctcaagc 990601 tgctgtaata cggcggtcac atactgtgaa ttccggtatt tccagtccat gctgtcgatc 990661 gtccaatccc agtacacaaa cccatctttc tccagattgc gaatttgtga ggcggttagt 990721 gacggcttgc ttccgtatgg cgttctgaca agatcggttt tatatcctgt aatgtcctgc 990781 agcgtgtcac gcgcctcctg catttctttt agcggagatg tcggtgtttg atagaacaat 990841 ctgttattgt gggtaacgcc atgtaaaccg agtgcgtggc cttccttttc tgctcttttc 990901 acagcctgct tgaattcgtt catccgcggt gacagcataa aaaacgtcgc ttttacatca 990961 gcgcttttca gtacgtcgag caagcgggtt gtaacggctg aagggccgtc gtcgaaggtt 991021 aagtaaaccg ttttatctcc catgttctgc tttgtctgca gatgttttat caggagatcg 991081 ggggagtcgt ttttcagctt aaggctttcc ttctcatctc gaagctggcc gtttgttgtg 991141 acagtgactt cctttgcttt cgttgaactg ttggaataac ccaaaatcac cataagcaaa 991201 agcagcacac ataaaactgc taaacttgca aatttaaaag caagcgaaac tgcagaagga 991261 gaagcctctc ctctcgtttg tcgcataaca atctctccat tggcataaaa tctctacata 991321 atgctgtaca gcaggcagct tatgaagatg ccttatgttt acaacctatg tattaccagt 991381 caagtataca ggaataaaac tggaaagcac atagaaaatt tgtcgaaatg tcagatttta 991441 aggaaaaaat aaactccttt ccgctataga tctcttgatc tttctgtttt tcagcttgtc 991501 caatatggta gaattagtga taatgacagc ttgaatgaca tcagggacat ctcgaaaagg 991561 gagggctttt atgaaggttt tagtcaatgg ccggctgatt gggcgcagtg aagcatcaat 991621 cgatttggaa gatcgcggtt atcagtttgg tgacggcatc tatgaagtga tcagggtgta 991681 caaaggagta ttgttcggct tacgtgagca tgcagagcgt tttttcagaa gtgctgctga 991741 aatcggaatt tcactgccat tcagtataga agatctcgag tgggacctgc aaaagcttgt 991801 acaggaaaat gcggtcagtg agggagcggt atacattcag acaacaagag gtgtggcccc 991861 gcgaaaacac cagtatgaag ccggcctcga gccgcagact actgcctata cgtttacggt 991921 gaaaaaaccg gagcaagagc aggcatacgg agtggcggcc attacagatg aggatcttcg 991981 ctggttaaga tgtgatatca aaagtctgaa tttactgtat aatgtcatga cgaagcaaag 992041 ggcctatgaa gccggagcat ttgaagccat tttacttagg gacggcgttg ttacggaggg 992101 tacatcctct aacgtttatg ccgttatcaa cggcacagtg cgaacacatc cggctaatcg 992161 gctcattctc aatggaatta cacggatgaa tattttagga ctgattgaga agaatgggat 992221 caaactggat gagactcctg tcagtgaaga agagttgaaa caggcggaag agatctttat 992281 ttcgtcaacg acggcagaaa ttattccggt cgtgacgctc gatggacaat cgatcggaag 992341 cgggaaaccc ggaccggtga ccaaacagct tcaggctgct tttcaagaaa gcattcaaca 992401 ggctgctagc atttcataaa tgaacgaaga aaagagcccg ctttttacag cggggctctt 992461 tttatttttt aacaaatcca atcaaaatgg agatcattgg cgatatatag aggaagaacg 992521 taaatgggat gtagtctatg actggaacac caagtgcgct cgccataaat gcgccgctga 992581 cgccccaagg aatcaatggg ttaattaatg ttccgccgtc ctctaatgat cttgtcagaa 992641 attttcgctg gatgtttcgt ttgtcatata aagatttaaa tgattgtccc ggtattaata 992701 tcgataaata ctgttcgccc gttgccaagt tgacgccgat gcttgagcag acagttgctg 992761 caacaagacg gccttttgag cggatgcctt tcatgacgcc ttccaatagt gcagaaatca 992821 atccgatttt ctccatcaat ccgccgagtg caaaagcaat cataatgaga gagacagagc 992881 ccatcatgga ttgcagtccg cctctgttaa taattttagc ggctgcctca ttgtcagttt 992941 cgaaagttgt gccattttgt aaagctgtca taaacgcctg caggctgctg tagggtacaa 993001 aaatagcagt caaaattccc gaggaaataa ttccggcagt cagaacgggg attactgata 993061 cccgtttcat tgccagcaaa acgactaaga gcggagaaag aagggcccac ggtgtcacgt 993121 ttgcagcatc ttttattccg gttatgacct gctgaatatt atcggttgaa gcagcgtccg 993181 ctgacactga tgaaccgaga aagtaaaaca gaacgacagt gatgagcaaa gctggaatgg 993241 ttgtgcccat catatggcga atgtgttcaa agattggtat ttcgcctatt ccggctgcaa 993301 agttggttgt gtccgacatc ggcgacattt tatccccaaa acaagcgccg catatgactg 993361 cgcctgctgt ccattcaagc ggaacgccag ccgcgctcgc cacgccgatc agcgctactc 993421 cgattgtgct tacagttgtc agacttgagc caacaagtgt gctgatgatc atacatgaaa 993481 acaaagcagt caacagaagg tggcttggtt caataaagga tagggcataa actgtcatag 993541 tcggtattgc gccgctgtac atccaggcgc cgattaagat gccgatcagc gctagaacaa 993601 taatcggctg tacgccgttt ttgatcccgt ctacaatccc tttttcaatg ctcttccagg 993661 gaaatccaaa ccataaagct gctgctgaaa gcatgacaac acttaaaaac agcgggatat 993721 gaggttctac atgaagcaag aataagcaag aaataataat gcacaacatg aatataaata 993781 aaccgacggc taacggaaac gtcagctttt tttgagaatc caaaataaca ccccatattt 993841 atctttaatg cttttgtgct tttgggcacg aaagcattat aacagaaaaa aacgaaaatc 993901 tatgtttttt cacaattatg aatataaaag aagtgagcac agggcgtgct cactttacaa 993961 tcaggacggg tatatccgat ttcgctgaaa gcttttcact tacacttccg aatattagct 994021 ttttcagcct gttttggtct ctgcttccgg ttacgatcat atcggcagaa atgcggtttg 994081 catgctcgat aattgattca gccggatcgc cttctaatat atcgatatct ccatctgcct 994141 gctgttcatt cagcatcatt ctggcttcgg cgatgacttc ttccgtacgg tcttcataga 994201 tcattggctc aggtgatgtt acatccgata tcagcggatc aggaacactt gtcatgcctc 994261 cgctgatata gcttgcctca gctgcgggtc tgggcgggtc gatgacggtc tgattgtctt 994321 tcatatcatg tgaatgggcg acggtaatag cggcatttac ggttttagca agatcaatgg 994381 ctgtcagaag cgctttctta ctattttcac ttccgtcaaa cgcaacaatg atacggtcag 994441 catggaacat ccttctcacc ctttcaaagc gtcttacaac actactaccc gaatttgagc 994501 acaattaacc ttttcctatt caagtaatga ttgacaataa aaggttttgt ttatatgatg 994561 ataaaaagat gaaatcagaa tggaaggagg gtttgctatg ccaaggaatt tgcgtgttta 994621 tcaaacagtt tcatattggc gcggcaaacc ttttgttctg ttttcgtgaa cggtttttta 994681 ggtcggaccg cgcgctgaaa agcgctgtgc gtaacatatc ggttaaaaaa ggcatggagc 994741 tgacgcttca tgcctttttt atatacaaaa tctaaggaaa gacaggtgta tgggatgtga 994801 agacaaatac agaggcgagg gcagttcgtg ccaaactgga tgaaaaaagc tgcaaggaaa 994861 aaatagaagg cggctgatga ggagatgggg atagatgttt tcagttttga aaaagcttgg 994921 ctggtttttt aaggcgtact ggctgcgcta tacgattgcg attgtccttt tattagcagt 994981 caatgtcatt gaaatgtttc cgcctaagct cttggggaac gccatagatg atatgaaagc 995041 aggggcattt actgcggaag ggctgctgtt ttatatcggt atcttttttg tgctgacggc 995101 ggccgtgtat atcatgtctt atttttggat gcatcagctg tttggcggag cgaatctgat 995161 ggagaaaatt cttcgtacga agctgatggg gcatttgctg actatgtcgc cgccgtttta 995221 tgaaaaaaac cgaacaggcg atttaatggc acgagggaca aatgatcttc aggccgtcag 995281 tttaaccaca gggtttggca tcttgacgtt agttgattct acgatgttta tgatgacgat 995341 ctttttgaca atggggtttt tgatcagctg gaagctgacc tttgccgcca ttatcccgct 995401 tccagtcatg gcgattgcaa tcagtctata tggaagtaaa attcatgagc ggtttactga 995461 ggcccaaaac gcgttcgggg cgctgaatga cagagtgctg gaatctgttt caggcgtgcg 995521 ggtgattcgc gcgtatgttc aggaaacaaa cgatgttcgc cggtttaatg aaatgaccgc 995581 tgatgtttat cagaaaaata tgaaagtggc ttttattgat tcactgtttg agccgacggt 995641 aaaactgctt gtcggcgcaa gctatctgat tgggctcggc tacggagcgt ttcttgtatt 995701 ccggaacgag ctgacgcttg gagagttagt gtcctttaac gtttatctcg gcatgatgat 995761 ttggccgatg tttgcaatcg gtgaactcat taatgtgatg cagcgcggca atgcgtcatt 995821 agatcgggta aatgaaactc tttcttatga aacggatgtg acagatccaa aacagcccgc 995881 tgatcttaaa gagcctggag atatcgtttt cagtcatgtc agctttacat atccaagctc 995941 aacaagtgac aatcttcagg atatttcatt tacggtgcga aaagggcaga ctgtcgggat 996001 tgcaggtaaa accgggagcg gaaaaacgac aattattaag cagcttttgc gccagtatcc 996061 tccaggtgaa gggagcatta cattttcagg tgtaccgatt cagcaaatcc ctcttgaccg 996121 tctccgcgga tggatcggat atgtgcctca ggatcattta ctgttttcac ggactgtaaa 996181 agaaaatatt ttatacggaa aacaggatgc aactgataaa gaggttcagc aagccattgc 996241 cgaagcacat tttgaaaaag atttgcacat gcttccgtcc ggtctggaga caatggtcgg 996301 tgaaaaaggc gtggcactgt caggcgggca gaaacaaaga atttcgatcg cgagagcact 996361 catggcgaat ccggaaatct tgattctgga tgattcactt tccgctgtag atgccaaaac 996421 agaggctgca attatcaaga acatcagaga aaaccgcaaa ggaaaaacga catttatttt 996481 gacacaccga ttatccgcgg tagagcacgc tgacctgatc cttgtgatgg acggcggcgt 996541 cattgctgag agaggcacgc atcaagaact gctggccaat aatgggtggt accgggaaca 996601 atatgaaaga cagcagctgt tcactgcgga agaaggggga gcaggggcat gaaaatagga 996661 aaaacgttat ggagatacgc acttctttat cgaaaattgc tgatcacagc cgtccttttg 996721 ctaactgttg ccgtcggtgc agaactgact gggcccttta ttggcaaaaa aatgatagac 996781 gaccatatcc tcggcattga gaaaacatgg tatgaagctg cggaaaaaga taaaaatgcc 996841 gttcagtttc acggcgtctc atatgtcaga gaggaccgat tgcaggagcc tgtttcaaaa 996901 gcaaaagaag cgcatattta tcaagtggga atggcgttct attttgttga tcaggctgtc 996961 agcttcgacg ggaatagaac ggtttctgac gggaagctga cgatcacaaa cggagacaag 997021 agccgggcat atgctgccga aaagctgact aagcaggaac ttttccagtt ctatcagccg 997081 gaaataaagg gaatggtgtt actgatctgc ctgtatgggg gcttgcttgt gttttcggta 997141 ttctttcaat acggacagca ttatctgctg cagatgagcg ccaatcggat tattcaaaag 997201 atgaggcagg acgtgttttc gcacatacag aaaatgccga ttcgctattt tgacaacctt 997261 ccggccggaa aagtcgttgc gcggattacc aatgatacgg aggctattag ggatttatat 997321 gtcacagtgc tttcaacatt tgtgacaagc ggaatctata tgttcgggat attcacggct 997381 ttgtttctgc ttgatgtgaa gcttgcgttt gtatgtctgg caattgtgcc gattatctgg 997441 ctgtggtcgg tcatataccg gagatatgcg tcatattaca accaaaaaat ccgctcgatc 997501 aacagtgaca ttaacgcaaa aatgaatgag tcaattcaag gcatgaccat tattcaggct 997561 ttccgccatc aaaaggaaac aatgagagaa tttgaggaat taaatgaatc acatttttat 997621 ttccaaaaca ggatgctgaa tttaaactcc ttaatgtccc ataatctggt caatgtcatc 997681 cgcaatcttg cgttcgtctg tctgatctgg cattttggcg gtgcgagcct gaatgcggcg 997741 gggattgttt ctatcggtgt gctgtacgcg tttgtcgatt atttgaaccg gttatttcag 997801 ccgatcacag gcatcgtcaa tcagttttca aagctggagc ttgcaagggt ctccgccggg 997861 cgtgtttttg aactgcttga agaaaagaat acggaagaag cgggtgaacc ggcgaaggag 997921 cgcgcgctgg ggcgggttga atttcgtgat gtgtcatttg cgtatcaaga aggtgaagag 997981 gtattaaagc atatttcctt tactgcgcaa aaaggcgaaa ccgtagcgct cgtcggccat 998041 accggatcag gaaaaagctc gattttgaat cttctgtttc gtttttatga tgcgcaaaaa 998101 ggtgatgtct taattgatgg aaaaagcatt tacaacatgt caagacagga actcagatcc 998161 catatgggta ttgtgcttca ggacccgtac ttattctcgg gcacaatcgg atctaacgta 998221 agtctggatg acgaaagaat gactgaagaa gaaataaaaa atgcactgcg gcaagtcggt 998281 gctgagcctc ttcttaagaa gcttccgaag ggcattaatg agcccgtgat tgaaaaaggc 998341 agcacgctat cctctggaga gcggcagtta atttctttcg ctagagcttt ggcgtttgat 998401 cccgcgatct tgattttaga tgaggcaacg gcgcatattg atacagagac agaggccgtg 998461 atccagaagg cgcttgatgt cgtcaaacaa ggacgcacca ccttcgtcat cgctcaccgg 998521 ctttcaacaa tcagaaatgc tgatcagatt ttggttcttg ataaaggaga aattgttgag 998581 agagggaacc acgaggaact gatggcatta gaaggccaat attatcaaat gtatgaactg 998641 caaaagggac agaaacattc cattgcataa cgctcaaaaa cccaaaacaa tcgtgttttg 998701 ggtttttggt ttatgtagtc aataagccag tccgacacgg tttccgacat actcacctgt 998761 aacgagctca cgatataaaa agtccgcagt atcgccgacc gaaatgcttg tgccgccctc 998821 aggcaaaacg ttacgctccg tacgataaac gccggttgct gttccgtccg ggaggtaagt 998881 ggggcagatg attgtccagt ctaatgatga ttctttaagc atttcgtata cttttgcatg 998941 ctccttggct gcgcgggtct gctttcgttt cgattcattt gtttcaaacc ggtattttcc 999001 cggttcatat cgggaatcta ggatccctgc ggtgccgatc gtaataagcc gtttgatatg 999061 ctgttcctcc ataacggaga gaatgtgtgc catagcagtt gacaaggtat catcaccatc 999121 tgtgcctaga cagctgatca cgatttcagc attctccatt atttttttca catcttctaa 999181 gcggcgggcg ttccccatga cagttctgtc ttttgaaagg ggaagatcag catgttgaga 999241 tctgatcaga gcgaaaatat caaatctttc atctgctgca gcttgtgtta aaaaggcttg 999301 tccgacgcgg ccgctggctc ctaataaagc gattttcatt aaaaaacctc ctcgcctttc 999361 attataaaag gatgttctca gtttgaacag cgcgggaaag aatacctgta caaataaaca 999421 gaacgatggg aaacatattc atgaatcatg gatacactta cgaattgaac cagctcccaa 999481 ttcacaatgg tgatgaatga caccccgatt ccctcccttt ttttctagga tatgtggagc 999541 aggaaaaaag ggtgacaaaa taaagagagc gcggaaaccg cgccctctat agccatatat 999601 tgaattgtta ttgaactctg ccgcccattt gctgctgagc gaaagatact aaacgttttg 999661 tgatttctcc tccgacagaa ccgttagcgc gagaagttgt gtccgctcca aggttaacgc 999721 cgaattcaga agcgatttca agtttcattt gatcgatagc ctgagctgcg ccaggaacta 999781 gtaagtcatt tgaagagttt tggttagcca tgtgtaaaat ctccttttta tttagtatgg 999841 ttgggttaac tggagttgca ccaatctgtg aacccttctc gggtgtcact gccgcctcgg 999901 cgtaacccaa tgctttgccg gcttgttact acgtattatg ttaaaatggc cggaaaatca 999961 tgcggagaat tgtgtggtaa atcttgagaa ataaaaaaag cttagccgtt taggctaagc 1000021 tagtcataaa tatgaaaaag catcagttca tgtatctcgt ttgtaagagc aggctcgtca 1000081 gcgcgggcgg gaaacaagtc tccccattca atctcaccgc tcttatgata gatgccttca 1000141 taatgggtcc ctttataata aaatgaaatt ttccatccgg gcagcttttc ttttgggaac 1000201 aaaggtttcc agctgaaatg agaaatcatt acggccacgc tccttacatt tggtatcaat 1000261 tgacctaaat aaaaacggct tatgttcatt gtatcattgt ttcagaacat cattgaagag 1000321 gcctaaatat gcagtttgtc ccagctttgg ataaagataa gcccgcttta ttaaaaaagc 1000381 ggacaggtta cgaaggccac aatgcttccg gagatgtgat tgccttctca gataaatatg 1000441 acgcgtattc aaaacttctt cgttttgtaa gagaatcaac atgatgcaaa tttggatgag 1000501 aaaaaatgct tcggcccggg cgcgaattcg cttcaaacat ccatacttta ccgttctgat 1000561 caatgccaaa atcgaaacca atctccccga taaatccctc gatatgatca tgaaggacat 1000621 ggcttgcagt cagtgccgct gcagaaagct ttttaatgac ctcaactctt tcagcgggat 1000681 catcgtatac ttccgcaagt gtctttacag tgccgccgtt agaaagatgt gttgtaatgc 1000741 tgttctttcc ggaaattttt acggcgattg ctgtcactgt ccattttcct tttctgtttt 1000801 tattggtatg gacacggaaa tccgctggtt tgccttgaaa ttcgatgaga tcaacacctt 1000861 gctgaatgag aaagtcggac gggttgtgat gtttttgaaa ttctgcaagg aatgaggcgg 1000921 catcggaata atcaattgat gtaaaagttt tggcgtcatt cgtatgcttt accgtcaggc 1000981 cgccatctgt tcttgtcagc tgataaatgc cggtgccgag tgctccattt gccggtttga 1001041 tatagacttt tttgtatgcg ccacagagct catctatcag ctccacagac ggtgtcagct 1001101 cggatctagg caaaaagggt gccgttcttg gatctttttc gagcaattga tgaacgttcc 1001161 atttattgaa aaacgtttta ttaaaccatg ggatctgata ttcatcgatc agcctctttt 1001221 ttgtatgttg caagagaagt gaatcttcaa tttttcggtt cggcaaacgg tcataaacga 1001281 cgttcggcaa tggaacgatt tttttctccc agccgttttc cctgtaaagg aggccttcaa 1001341 tcgtgccttc ctcccaattg atttggtgcg cgccaaaaac gaagcagtag cccccggctt 1001401 gctcgtgtaa cgtgacaagt ttagaaaaaa agagggaacg atccttaaat gggcgttcaa 1001461 gagatacagt aaaccctgcc gtaaagatgc cgactaacgg cccgatatgc actgtatgat 1001521 catgaatcag tatatctgcc ctgcttcggt ggggaagcaa aagctcatga aacagatttt 1001581 cagagagaag cacggtttgt tccagatgcc gtctgtaagc aacgtggcat ctgacaacct 1001641 tcgttccgaa tgcggcatgc aaaagtccgt cttgcttcag cgaagagggc agaaacaggg 1001701 tgttttcact ggttttgtct atgccgatca aaaaccgttt aggattcacg cggaagaact 1001761 cctttctggc tttgctcaga aaacagatat tggcagcgtt ttaggggaca agtgtacagc 1001821 tgttcttttt gctcgggaga gacacgcagg attgacttcc tgcctggttt ggaattgata 1001881 tctaaaatcc aaattctccc gtcctttgca agacatatat caagaccgag ttcaaacaac 1001941 ggcccatagc gctcgtcaag ataatacgga accgattggg taattgaaaa cacatcatct 1002001 agtaaaacca cttgctgttt tttcggtata tcttcaaacc aggagtcaaa tgtcagcgca 1002061 tcagatccgc ctgacaaatt ggccagcagc ccgtgtttgt atccgcgtct tactgccttt 1002121 ccgactgtat tccattcacc tgcttcgttt ttttccataa acagacgaat atcacaaggg 1002181 tattgttcct tatcttgaat gtttaagtaa ggctgaagca aatattgatg ctgaagcact 1002241 tttttgcacc atgttttaaa agaagtctgg ttggaaaacg tttttgtctg cttatccttt 1002301 ccgatgtgat aagtagcagt gatgtttttc ttgcccagct tcaaaagaat cacgcctctg 1002361 cctcccgcgc cgaatgccgg tttaaggatg caggcttttt ctttggataa aaaggagtga 1002421 atttgttcgt agcggctcac ctttatcgtt tcgggaatat agggattgat tacagagtgc 1002481 tgctgcaaat cgtgaaggac ggtccactta tcgggaagac cccgcccgat aaattccgtt 1002541 ttcggatatt ttttgagcca ctcaacgatt ggttttgctt tttgggaatg tgaatccttg 1002601 ccgtaaaaac agcgatcata aatataatct ggaatcgcca tttcagtttc gttccatgtg 1002661 ctgctggccg aatgatagac cgatgctttg acacgcaaag tgtcaggtga aatatcaaat 1002721 ggtgtaaacc ggatgaaacg tatgccgaat tcgggtgctc ttttggccag ttctgcggaa 1002781 taatccgctt catgctggcg ggataaggac ataaaaccga gtgttatcat ggtgagactc 1002841 ccccttttat tcaaaagctg ccggcgggtg tccgcagctt tacactaaat acatgtaaga 1002901 cgaacgcagc tgacggtatt ctactttaca gaatacgatt ctccaccttg ccctattcca 1002961 aaagaacaag ctgattttct aagaacagga atttgtctcc tcgtttgcta agtgattgca 1003021 tgagcctcta taatacgtat aggtacataa tctatatgaa aaaagctgaa gcacagatgg 1003081 aggaagatga ataggaatgg gtattgcagg aacctttatt tttatgatcg tgatcggcgc 1003141 tgccattgga gcggtgacca atcatttagc aattcaaatg ctgtttaggc cgtataaagc 1003201 gtactatttg tttgggaaac gagttccttt tacgcccggg ctgattccaa gacggcgaga 1003261 tgaacttgca aaacaaatgg gactgatggt agtcaatcat ctcttaaccc ctgaaggcat 1003321 taaaaagcgg ctcgtctctg atgcagccaa aacgcaggct cttcgagtgg gggaacagct 1003381 gattcaaaag ctgtcacttt ctgaagtgac agtaaaagaa gcgcttgaaa aagccgggat 1003441 gaagcgcccc gaaaaagctg ctgatgcatg gatcagcagc tggaccgatg ataagctgca 1003501 tgagcttttc cgccaatacg gggaccaatc gttaaaagag ctggtgccta tagaggtgca 1003561 ggaaaagctt gaggaaaaaa ttccgatgat ttcaggatat atattgtcac ggagtgtccg 1003621 ttattttgaa agtgatgaag gaaaaatccg tcttggcaat atgattgatg actttttaaa 1003681 agagcgcggc atgcttggaa gcatggtgca attgtttctt ggcaattcaa gccttgcgga 1003741 tcgcgtgctg ccggagctgc tgaaattctt gcgcaatgag gaaacaaata aattgctttc 1003801 tgatctctta aaaaacgaat ggggcaagct gagggagtat acgtttaatg aagcagatga 1003861 aaaatggaat gcaaaggcgc tcattttcag tttgaaacga agagtgctgc aagcattttc 1003921 gactgcccct ttcttcaaca atacgattgg cacgcttacc gtccgctatg aatctgagct 1003981 gacccagcaa atgctgccgg cactattaga caaattgctt gaaggtattt cgtccaacct 1004041 tgaaagtgtc ttaaaacggt tgcgtcttga ggaaatcgtc aaggagcagg tggatcagtt 1004101 cccggtggag cgtcttgaag aaatggtgct gtccatttca aaaaaagaat ttaaaatgat 1004161 tacctatttg gggggccttc tcggcggaat tataggcgcg attcaagcat tgtttgtcat 1004221 ccttttttaa gaagaaatgg tttttgatta atgaaaggag ctccatagtc tgttatagtg 1004281 gagtggtatg tcaaacggca atgatgaaag gagctattta caatggctgt taatttttat 1004341 gatgtagcgt atgatctgga aaatgcatta cgcgggagcg aagaattcac ccgtttaaaa 1004401 aacctttacg acgaagttaa cgcagatgaa tcagcgaagc gcatgttcga aaacttccgt 1004461 gatgtacagc ttagactcca gcaaaaacaa atggcaggag aagagattac acaagaagaa 1004521 gtgacgcagg ctcaaaaaac agttgcgctt gtacagcagc acgaaaaaat ttctcagctg 1004581 atggaagcgg agcagcgcat gagcatgctg attggtgaat tgaacaaaat cattatgaag 1004641 cctttagaag agctttacgg cagtgttgaa ggctaataag caaaatccct tcttggataa 1004701 gaagggattt tttattcact cagcaaactt ggaaatccaa tgaatctttt acctctccat 1004761 tgatgatgac tgataatgta tgaattcctt tgtaatgctt tctggtggtt aaatccttaa 1004821 aggattggat tcttgtgtat gacttcgttt cgttttttcg tatatttgtt tctgttattt 1004881 taaatacttt ctgatgacgc tggcctcttg cttttacaaa atcaattgcg tactcaattc 1004941 ttactttttg atccctgtct gaatgaatat agaaagaaaa ttcaaggctt tcgccaataa 1005001 ctatacgttt gggctggcat gttaaatcat gtagttgtat cgaatcagca ttttcataac 1005061 caaaaagcgc taaggcctgt ttatcaccct tttttaataa ggtccgatag gcgtgtttga 1005121 taatccagtc tgtatgggga tgtgttccgt accattgatc tgcgactttt ctcagtaaat 1005181 gaggatgcgt ttttgatata tcattaaggt tgttggccac gctttttctt acatataaag 1005241 actcgtcctg catcagcttc tcaaggatcg gcaatacggg ggaagggtcc gatttcaaag 1005301 ccggtatcga ttttccccat ggcaggcggg gcctgctgcc ttcgctcgca agtcttctca 1005361 cgtgttcatt tttatgctca gaccatgcaa gcaattgtgc aatcatcttt tcttgatcta 1005421 acagcaaaaa aggccttaca gcaaattctg aggtcgaata ttgcgtaaag gattccaatg 1005481 cctttattga ttcttcccaa tgcgctaacc cgtactgttc cacataatct ggaaataaaa 1005541 ttccgctgag tcctttaaaa tgaggggctg tatcccgtaa aattgtgagc gcttcaacgt 1005601 attgttttgg caaagtttcg tataaagaaa ctgtcacgcg gcgcatccgc tcttttaaag 1005661 tgagttcagg ccagtcctcc agccgtaatg tatccaagaa tctgtttttg ttaaaatcag 1005721 gataggatga ccttacatga tggatcaact gagatatcag ttcttcatta tatatttctt 1005781 ttaaatcagc catataaaca ccgctttttc gtttattatt tatattgtat gggaatgtac 1005841 gttctggatc aagtgtatag tcctaaaaat taacaactga tcctaccacg gatatacaaa 1005901 agttggttac tttttttagt taaaaaaacc cttgtcatcg gaaaggaaaa ctgagataat 1005961 aacattgaaa gcgcctacac ttacctattt caaatggata cggtcgcata tcatgccgtt 1006021 atatagaggg gataagcaac agagagtaag tgttcggagc gcatcattgg tcaaacaagg 1006081 ggttcctgat acatgatttt tcgtaaatcg aaataacgat attagggaga atggctgctt 1006141 cgatcgtatc ctatcaacaa gccatacata aagtctgctg agccaggctt tttttgcttt 1006201 aagaaaaggt tgttctaaac acagagacag ggtcatatcc tatacacaag tacagtcatc 1006261 aaggaggggg acatctctgt gtcaaaacaa ttgcttgcct taaatataga tggagcgctg 1006321 cttcggtcga acgggaagat tcatcaggca acgaaagacg cgattgaata tgtaaagaaa 1006381 aaagggattt acgtcacact tgtgaccaac cgtcattttc gctcagcaca gaaaatagcg 1006441 aaatcgctaa agcttgatgc caagctgatc acccatagcg gggcatatat cgctgagaaa 1006501 attgacgccc cgttttttga aaaaagaatt tctgatgatc atacctttaa cattgttcaa 1006561 gtgctggaga gctatcaatg caatattcgg cttcttcacg aaaagtattc catcggaaac 1006621 aagaaaaagg tgaattcgaa tttattaggg aaagcactca ttcatccgtc tgacccgatc 1006681 ttttatccag tccagttcgt tgaatcatta agcgatctcc tcatggatga gccggtgagt 1006741 gcacccgtca tcgaggtgta cacggagcac gacattcagc atgacattac agaaacgatt 1006801 acaaaagcct tccctgcggt ggacgtgatt cgcgtaaacg atgagaaact gaatatcgtc 1006861 ccgaagggtg tctcgaagga agcgggtttg gccctcgtcg cttcagagct gggcctgagt 1006921 atggatgatg tcgtggccat tgggcatcag tatgacgatc tgccgatgat cgaacttgcc 1006981 ggtcttgggg tagcgatggg gaatgccgtt ccggaaatta agagaaaggc agattgggtt 1007041 acaaggtcca atgacgagca aggtgtcgct tatatgatga aggaatattt ccgaatgcag 1007101 cagcgaaaag gatttcttga taagttccac atgaaacgtg tgtaaaaaag ccgctcgcgc 1007161 cctgacaggt gcggcggctt ttttgccgga ttgattttag cagtttattt ctgtacacta 1007221 aagaaagttt tgaatctgat aaattaggtg atgaagttgc aaattaaaat agaaggcata 1007281 catgatgacc gcctgcatcg gcctctgcaa aatattgcaa atttgtttta tgaagagtgc 1007341 gagcttgcgt atggcggaga ggagcccgca gattttgtca tttctttagc gttgtcacaa 1007401 acggatgagc atgtgacggt ttctggagaa gtgaagggta ctggcataaa ggaacagcat 1007461 acaaaattct tttctccaga catgactgaa aaagaagctt ttaagcaagt gaaaaacaca 1007521 atttcttatg tgtatctcaa tcttcttcag gcgcatacgg gcattacgca gaagtgggga 1007581 atcctcacag gaatccggcc cacaaagctg cttcataaaa aactgcaaag cggaatgtcc 1007641 aaggagcaag cgcatgctga gttgaaaaaa gactatttaa ttcatgatga aaaaatcatg 1007701 ctaatgcagg aaattgttga ccgtcagctg gcggcagtgc cggatttgta ccgagtaaag 1007761 gatgaagtca gcatttatat cggcattccg ttctgcccga caaaatgcgc gtattgcaca 1007821 ttccctgcgt acgctatcca aggacaggcg ggcagagtcg gctcattcct atggggactg 1007881 cattacgaaa tgcagaaaat cggtgaatgg ctgaaggagc atgatgttaa ggttacaacc 1007941 atttactttg gcggcgggac gccgacaagc attacagcgg aggagatgga tctgctgtat 1008001 gaagaaatgg tccgctcctt cccggatgtg aaaaacattc gtgagattac ggtggaggcc 1008061 ggtcgtcctg acacgattac agaagaaaaa ctcgccgttt taaacaaata tgacattgat 1008121 cggatcagca tcaatccgca atcctacgaa aacgaaacgc taaaggcgat cgggcggcac 1008181 catacggttg aagagaccat tgagaaatat catctgtcac gccagcacgg catgaataat 1008241 attaacatgg acttgattat tggtttgcct ggggaaggcg tgaaggagtt caggcacagt 1008301 ctttcagaaa cagaaaaact gatgccggaa tcccttaccg ttcatactct ttcatttaaa 1008361 cgggcgtcag aaatgacgag aaacaagcat aagtacaaag ttgccggcag ggaagaggtt 1008421 tctcaaatga tggaagacgc ggtagcctgg acgaaagagc atgggtacgt gccttattat 1008481 ttataccgcc agaaaaacat tcttggaaac cttgaaaacg tcggatactc tttgccggga 1008541 caagaaagca tctacaacat tatgattatg gaagaggtgc agacgattat tggcatcggc 1008601 tgcggcgctg ctagtaaatt tattgatcgg gatacaggga aaattacgca ttttgcgaat 1008661 ccgaaagatc cgaaatcgta caatgagcgc ttcgagcact acacggacga aaaaatcaaa 1008721 tatttagagc agatttttga aaaaacgaca aagcagcact gattacagtg ctgctttttt 1008781 tatccctgtt tttttgcggg ctgaacctca ggcttccatt taaatacctt gttcagcaag 1008841 cggtaaattc gttttgattc ctttgtgaca agcggtccca aaatcgccag aatgaggaca 1008901 tataatgcgg caaacggctt taatgtggcc gacagtccgc cggctatccc gagattcgca 1008961 acgataatcg aaaattctcc ccgcgatacg atcgtcagcc cgatattcga tgaagcctta 1009021 tgagaaagcc ctgcgcgtcg tcctgccacc attccggcga taaaatttcc cagaatggtc 1009081 aaaatcactg cacccaacgc aagccaaacc gcttcaccaa gcgaaaacgg atcgatgctg 1009141 aggccgaagc tgaaaaagaa catcgcaccg aagaagtcgc gaaacggaac aacgaggtgt 1009201 tcaatcctat cggaatgctc tgtttctgaa aagaccaaac cgagcagcag cgcgccgatt 1009261 gcttctgcta catgaatcgt ctctgaaaaa ccggcgataa aaaagagtgc tgcgaaaatg 1009321 acgataataa acacttcgtt tgagcgaatg tccaacagtt tgttcaacag cggcgggagt 1009381 tttcttgctg cgataaaaaa cagcagcata taaccgaagg cgatcaaaat ggacaagagt 1009441 gcactcccta cggatgtcgc atcacctagt ataaggccgg aaacaacgga cagatatacg 1009501 gcaaggaaaa tatcttcaaa catgatgatg ccgagaatca attcggtttc cgggttggcg 1009561 gttcttttta aatcaacgag cacttttgcg acaatcgcac ttgacgagat tgtgatgacg 1009621 cctgcgagga tgaggacttc cagaaaggaa aatccggtga taaacccgta aagcagtccg 1009681 aggctgaagt taatcaaaat ataaatcgtc ccgccgaccg cgattgattt tcctgatttg 1009741 attaacttcc cgacagagaa ttcgagtccg agatagaaga ggaggaacag tacgcccatt 1009801 cgcccgaaaa actcgatgat ttcactgctt tgaataaatg ttagatcaat aatccccatt 1009861 ttcggcgcgt gcggtccaac aagcattccc agcacaatca gaaacggaat aatcgaaaat 1009921 ttaattttat tggcgatcac actggcgatt gccacaagca caagtgcagt tccgacttca 1009981 aatacaagat ggtccatcgg ggctcacacg ccctctccag aaagaaaatc gtgaatcagt 1010041 ttcttcagat gctttctctc acctgagagg acaagggtgt cattttcttc aataatcgaa 1010101 tccgctccgg gatttaggag cttttcctgg ttgtgtttga taatcgcaat aacagtgaca 1010161 tcgtaattct ggcgaacatc aagctcaccg agtgtgcgtc cgatcgattt ggcgcctttt 1010221 tcgaccttaa accattcaat aataagatcg ctgaaggcca tttcgatgga ctccagagct 1010281 tgcggtttat agaccatgcc cccgagaata gctgcaattt gccttgcttc agaatcatcc 1010341 aatgaaatat ttgaaagaag ctcatccggg tcccggtcat taaaccggta aatttccctt 1010401 cttccgtcat catgaatgat aatcgtcatt ttttcgtggc ttcttgtttc gatttcaaac 1010461 tttttgccga tgcccggcag atcgttttct ttaatattca atgaaaatcc ctccgaatgt 1010521 agtgttggca gtatggggtg agttacaaat aaaacttgag caaattatat tcggaggtaa 1010581 ttagactggt atttgacagg gacggccaaa gccttttcca gcctgtttat cagcggttcg 1010641 tcaagtggtt tgacagagag ctgcctgaca gactgcgcca gcgggctgta ctctttgatc 1010701 agctcagccg ggtgcatgct gcccggcgat ggcgtttttg ccgattgtgt ttcctgcgga 1010761 tatgaagaca taggcacata gctgtcagtg cttgcttcaa actgggaagg cagaaccacg 1010821 tccgaagggg gaaagtacac cataaataaa cttaacagaa aactgatcag caatttatcc 1010881 atgttccttt cctcccttct catcaagata tcccttcttt ttcactatat aaaactttat 1010941 gtttccattc aaacaatatg catttttcag tatctattga ccttgaaaaa taaaaaggtt 1011001 tatttgggga tggcggggaa tgtataggag aaagaaaaaa gtaagcgcat acatggaggt 1011061 gcttttaatg gagtttgttc aatatgcatg taatggggcc gttgcagaga ttatcctgaa 1011121 tcggcctgat gcccatcacg ccctgaatga acagatgctg tctgaattga aggaggcagt 1011181 cgaaatggcg gctgcaagcg aggcgctcat cgttctcctg agaggaagcg ggaaaggctt 1011241 ttcggccggc ggtgatatca ggatgatgac gtcagagcat gaccctgacc aatttaaacg 1011301 gctgatggat acgattgagg ctgtcaccct gaatttatat cagatgaaga aagtgacaat 1011361 tgcagccatt catggtgctg ctgcgggact gggcctgagt ttggcgcttt gtgcggacat 1011421 tgtgctcgct gaaaaaaacg ccgttctcgc gatgaatttt atcggcattg ggcttgttcc 1011481 ggacggcgga ggacattatt tgctgaagaa aagaatcggt gaagcaaaag cgaaaaaact 1011541 gatttggagc ggaaaaaaac tatctgcctc ggaagctgcc gatatggggc ttcttgatgg 1011601 gacatttgcc ggagaccctg ccgaaggcgc aagacccatt atcgaaaccc tgttggcctc 1011661 ccctcttttg gcgatgatcg aaacgaaagg tatttttcaa agcctccaaa ttgaagaact 1011721 gaaaaaagtg ctatcccttg agcgcagcgc ccaagagaga atgagaagga ccaaggatca 1011781 ccaagaagga atccgtgcct ttttagaaaa acgggagccg aagtttcaag cgtaacagat 1011841 cagccggaaa gctgatcatc tgtgaaacaa aatcagcttt ccggctgcat tgactaaacg 1011901 atgagtatga ctatgaagct ctttttcttt taagagggct tcaccatgcg tttttgccgc 1011961 ttcttcatgt tctgcctcga attgctcgtt taccagcgtg ttccccgaag gatcaaatac 1012021 ggtaaggaaa taatcagcca tcaggtttct cctccatttt aaggtttatc agtctttctt 1012081 catttatatt ctaaaaagga aatcaaaatc ctttattatg ctttatccaa aattagtata 1012141 taatgggtca gggaaggagg agattcagtg cttacaattg atcacgtaac gaagacattt 1012201 ggagattata aagccgttga cggattggac ttagatattc cggaacagca aatgttcggt 1012261 ctattaggcg caaacggagc gggaaaaaca acaacgtttc gcatgatcct aggattatta 1012321 agcattacgg agggctcaat cagctggaag ggccgtcctg tgaattatca tatcagcaac 1012381 aaaatcggtt atttgccgga agagcggggc ctttatccga aaatgaaggt aagggatcag 1012441 ctcgtctatc ttgccagatt aaaagggatg gagaagcgag aggctgtaaa agagctcggg 1012501 acatggcttg aacgcttcaa tattacagat tacgagaata agaaggtgga agagctttcg 1012561 aaggggaatc agcagaaaat ccaattcatt tcggcagttt tgcataagcc ggagctcctg 1012621 attcttgatg aaccattcag cggcttggac cctgtcaatg ttgagctgct aaaagaggcc 1012681 gtgatctcgc tgaaaaacag cggtgtttct attttatttt caagccatcg gatggaacat 1012741 gtggaggagc tttgtgagaa cctttgcata ttgcagaaag gaaaaccggt tgtacaaggc 1012801 aagctgaagg agatcaagcg ttctttcggt aaaaagaatg ttaccattca ctccgatgac 1012861 gatctgcgct ttttgcagtc ccatgaaggc attcttcaat ggaaggaaac ggcagacggc 1012921 gtcaagctgc agattgccaa tgaagacatt tctcaagaga tttttgcgat gctccaagga 1012981 aaagggttta tcagaaagtt tgagcttgaa gagccgtcac tgcatgatat ttttatagaa 1013041 aaggtggggg ccgtctatga ataaattttg gatcatgctt tctcatacat acaaaaataa 1013101 gattatggca aaatccttta ttatttcgac tgtcatcacg gtgctgcttg ttttagttgt 1013161 aacgaatctg gagtcgatca tttctttgtt tcaaggtgac gatgcgaaag aaaaaatcgc 1013221 cgttgttgat gaaacaaacg aattatatcc ggttttttct aagcagctga aagcggtgga 1013281 tacagacggc gatcttgatg tgaagctgtc gaagcaatcg gaggatgagg tcacaaagca 1013341 agtcaaagat gaatcactcg atggcatgct catcatcaaa cgagatgaaa aagggaccat 1013401 ttcaggaaca tataaagcgt taacgatttc tgatgaaagc acgtatcaaa cactgcagca 1013461 ggcgctgacg caaaccaaaa cagctgtcgg aacagcggag ctcggcgtgt cgcaggaaac 1013521 gattagcagc ctttatgcgc ctgttactgt ggggcagaag gcgctgaaag aaggggcaaa 1013581 gtctgaggaa gagcttggcc agacggtagg gcttgtttac attatgctgt tcgtcattta 1013641 tttctcggtg attatgtatg ccagcatgat agcgatggag gtcgcaaccg aaaaatcttc 1013701 gcgagttatg gaaatcctga tctcaagtat gccgccgatc cagcaaatgt ttgcaaagct 1013761 gcttggtatc gggcttgtcg ggatcacaca gcttgctatt attataggag ccggctctct 1013821 gtcgcttaag ctgaaccaaa agagcgaaac ggcttcatct gtcggcggat tccttaattt 1013881 gaccgacgta tctgcaacca ctgtcatcta tgctgtcatt ttctttttgc tcggatactt 1013941 tttgtacgcg acacttgccg cgtttctcgg cagtgtcgtc agcagaatag aggacgtgca 1014001 gcaaacgatc acgccgatga cgcttttggt tgtcgccggt tttatgatcg cgatgttcgg 1014061 tttgaatgcg cctgacgcag gatttattac ggtaacttcg tttattccgt tctttacgcc 1014121 aatgattatg ttcctgcgcg tcggcatgct tgatattccg ttctggcagg cggctgtcgg 1014181 aatcggaatc acactgctca ccattgtcat actggccgtt atcggcgcca gaatttataa 1014241 aggcggtgta ttaatttacg gcaattcaag cgcgttcaaa gcgatcaaac aagcgctacg 1014301 tttagcgaaa aactgattgg aaaacagcct ggggattctc aggctgtttc tttattgaca 1014361 gaacgtgcat tcgcaagaat tcggtgctaa aataagggta cttcatcctg gaaaggagca 1014421 gaatgttgac tgatctaacc tttattcatg cggcagatct tcatcttgac agcccgtttt 1014481 acgggatatc gcatctgccg gagccgattt ttgcccggat taaagaaagc acgtttgcaa 1014541 gcgtgagaca tatgatagac gccgcagtga gagagcacgt tgatttcatt ttgcttgcgg 1014601 gagatctgtt tgatgaagcc aatcgaagct taaaggctca gctctttttg aaaaaacagt 1014661 ttgaaagact cagagagtgc ggaatttcgg tatacgtcat ctttgggaat cacgatcatc 1014721 ttggcgggga gtggacgccg attgaatggc ctgagaatgt ccatattttt tcgtccgctg 1014781 ttccagaaga aaaatcgttt tttaaagaag gcaggcgcat agcaagcatt tacggcttca 1014841 gctatcaagc cagagcattg atggaaaacc aagccgcccg ctatcggaga tcaactgacg 1014901 caccgtttca tatcggcatg ctccacggca cgctgtcagg atctgaagga cacgatccgt 1014961 attgcccgtt tacacatgac gacctcgtga aaagcgggat ggattattgg gcgcttggcc 1015021 atatacataa acgccaggtt ctatctgccg agcatccggc agtcatttac ccgggaaaca 1015081 cgcaagcacg ccatataaag gagacgggag ataaaggcta ttatctcgtt catgtgacaa 1015141 acggagatat atcttatgaa tttcagagag cgcatgatgt cctgtgggaa aaagcggcgg 1015201 ttgatgtgac ggaggcaaag aatatgacag ccctcttcca aatggtggag gacacgtttt 1015261 cgaagctgcg gaaaaagggg agccctgttt gtgtaaggct tgttttacaa gggacggcgc 1015321 cggaatggct gctggaggcg ccaaaaggca ccttggatga gtttcttgaa gctcttcagg 1015381 aacaagaagc ggaagaggaa cgtttcgttt ggcctcttag attggacgat gagacagaaa 1015441 acgaagcaaa cctaacaaac cttgatcctt tttttggcgg tttatttgaa gacattgatc 1015501 gcagcgatct gtcagacgtg ctggaagggc ttgagcggca tccagtgtat agaaggcacg 1015561 cggaccggtt tagccaagag gaggtaaagg aaataaaaga gcaggcacag ataatattga 1015621 aaagacagct taaggtgctt gatacatgag gcggtgacag ctttgcgaat tatatcttta 1015681 catatctacc aatacggaaa attttccaat cggacctttg acttttccgc ctctcctgtc 1015741 caagtcatct acggattaaa tgaggcagga aaaacgacga tgatgtcatt cattgaaagc 1015801 atgctgttcg gttttccgaa aacgaaaaag tatgaaccga aaacaggcgg tgtctacggc 1015861 ggtgttcttg aagctgaaca tcctgagtat ggggtgctga agatcgaacg gacgaaaggg 1015921 actgccgaaa aactaagcgt gtacacagaa aagggcgaag taaagcaggg agatgtttta 1015981 aagcagctgt tccagggcac agacaggtcg ttgtacaaag ccatatattc gttcgacgta 1016041 ttcgggctgc aggaaattca cgcctttaat cgggacaaga taggggaatt tttgctcttt 1016101 tccagcttgt ttggtgctga agccgtatca aagcttgatt caaggctgac gaaggaaagc 1016161 gaaaggctct ataaaccaaa tgggcgaaac cctcaattga atcaggagct ggaaacgctt 1016221 aagcagctgg cagttaagct aaaacaggct gaagcagagg aagcgggcta tcatcagctt 1016281 ctcgaggaaa aacgaacgct tgaagcccgc cttgcagccg cggaaaccga attgaaagag 1016341 acggcgggac atatccgaat gattgaggga gcgattgagc gaaagccgct gctaaatgaa 1016401 aaagcgacac tcgaacaggt gattgcagaa tttccggaac acgcaggaca atttcctgct 1016461 gacggactgc atcagctgga aaaatatgaa tcccatcttc acccgaaatc agcacagctt 1016521 gaggcgcttc gggtgaagat ggcggagttg gacaaacaga ggcaaaagct tatccccgat 1016581 aaagaactat tggcgaaaga aacgctgata caagagcttt cggcagcgtt tcatatgtac 1016641 caatcctggg gagaacagct ggcagccatt caggcacagc tgcgccagac gtctgcgcag 1016701 acagcggcag ggctggaaca gctcaataaa acggatgaaa atgagctcct gaatatgaac 1016761 acctcatatg attatgaatg gcagcttcag caagcggtgc agcaatatgt acaggcaaga 1016821 gacagaaaac ggcagcttga cgagacgttt gaacttgccc ggcaagagct ggaagacgcg 1016881 gaaaaggccg ttcgtgccgc ttcgtccgcg attcttgaaa acagccaaag aaaagataaa 1016941 gaagcagctc ttagagcata tgatgaaaca caggggcagc accaagagca agcgaagctc 1017001 agagaacagc taacgttttt tgaaagacag caggctaaac agaaaaagac tgtcattgca 1017061 gctggtatgt tgttcatcgt tctcttttct ctgctgcagc aatggattcc cgccataagt 1017121 ttcggcgctg cacttattgt gtattggctt gtttcaggaa agtcgtcttc tcgaaacagc 1017181 cgagagacaa gacagcccat gacggatatt tcaccagcag aagctgaaat gcttagagaa 1017241 gcgttatggg aggatgaccg caataagcag caccttctca cacagcgtgc agcgctccag 1017301 caaaaagagg cggcgtatga aagggtcatc cagcagtttg aacagtggga agccgaaatg 1017361 gcgccgtcct ttacacaggt tgagcgtttt atgaatgagc tcggatttaa ggaagatcca 1017421 tcatttttgc ttgatgcata cagcttaatg aaggatgtta aaaaagaagt gaagaaaaag 1017481 catgagctga ccatagaagc aggcaggctg aaaaagcacc ggagaacatt cgaagaacgc 1017541 gtcagtatgc ttcttcccgt gaatcagagt caggatatct ccatttcgga cgcccttcac 1017601 acattgcgga aaaacattga acgtgaaaaa gaaattgaga agcaaaaaaa ggaaattgaa 1017661 acagatattc attatacaaa ggaacagatg cttgaacttg agcaagaaat acagtatttc 1017721 cacgcacaga ttgaacagtt atttgccgcg gctgctgcaa aagacagaga tgcgtttttt 1017781 gccatagccg ccatcagcag gcaattgaag gatacggaga acaagcttca tcacgtaaac 1017841 gcacagcttc aaggcgggta cccggaggaa cttgaactgg cggattccaa tacgctttct 1017901 gaattgaaag ataagcaatt tgttgagaat gaaagaaaag agcggctgac tgaggagatc 1017961 gagcagctcc gcagccaaat cgcactgctc tcagtcaaac aggaacaatt agaggcttcg 1018021 ggaatggtct cagacctcaa gcttcaaacc gaaatgcaaa aagaacgtgt gaaagaaacg 1018081 gctaaaaaat gggcctccat acaaatggtc aaacaggtga tcagaaacaa attggagcgg 1018141 cataaaaaaa tcgagcttcc gcgccttctg gagacggcag gagaattttt ccgtcctctg 1018201 actgacggaa actaccaaac catttatttt tccgaaacgg atgattcgat catggttatg 1018261 catcgcgatg gcactgtcta tcatgcggaa gagctgtcac aagggacgtg tgaacagctg 1018321 tatacagcga tccgctttgc tttggccgtt acgcgccagg gtgagtcaaa gcttccgttc 1018381 cagcttgacg acagttttgt tcattttgat caggaaaggc tgaaacgtgt attacatgtt 1018441 ctgtatgatt tatctgaagg cggtaggcag attttgtatt ttacatgcca tgagcacgta 1018501 aaagatgcat ttcatagcag ccaaatcatc catttggtgt cataaaagag gttctatagc 1018561 tgaaaatcgg tatgtgatat actggtatta tgtaagatac ggagggagct ttaatagaat 1018621 ggctaaaggg attatgctac atgaggttgg cgaacaggtg gaccagtatc tattgattaa 1018681 atcctcgacg aaagggattg caagcaatgg aaaaccgttt ctgacgctga tgctgcaaga 1018741 ccagtcaggc gatattgaag cgaagctgtg ggatgccaag caaagtgatg aagtgaccta 1018801 tgcgccgcag acgattgtca aggtcgtcgg cgatgttcac cattatcgcg gacgcaccca 1018861 gctgaagcta agaaatatca gaccggtaag cgagcaagaa aacgtcaata ttgatgattt 1018921 tttagaaacc gcgccgattc cgaaaaatga aatgatggat accatcactc aatatatatt 1018981 tgaaatgaaa aatccgaata tccagcgaat cacaaggttt ttggttaaaa aacacgaagc 1019041 tgagtttatg gattatccgg cggctacgaa aaaccaccat gagtttgtct caggtttggc 1019101 gtatcatgtt gtctctatgc tgaacctggc gaaagcaata gcagatttat atccttctct 1019161 tgatcgtgat ctgctttacg ccggtgttat cctgcatgat cttggaaaag tgaaggagct 1019221 gtccggccct gtttccactt catatacggt tgaaggcaat ttgctcggcc atatttccat 1019281 catggtgaca gagctttcaa aagcggctga ggagcttcaa atcgattctg aagaggtgtt 1019341 aattcttcag catttgattt tgagtcacca cggcaaagca gaatggggca gcccgaaacc 1019401 gcctatggtg aaagaagcgg aaattcttca ctatatagac aatctggatg caaaaatgaa 1019461 tatgatggac agagcgcttg agcgcgtgaa gccgggcgag tatactgaac gtgtatttgc 1019521 actggaaaac cgttcctttt ataaaccgac atttcataaa taacttaaaa aggactgatg 1019581 ctgacatatt cagctcagtc ctttttgatg cgtctttccc gcacataact cgtctcattc 1019641 ccgcatatgg ttaagaataa agaatctatg caaaggggga ggagcccgtg ttattttttc 1019701 cgtggtgggt gtatctttgt attgtaggca tcattttcag cgcatataaa cttgtggcgg 1019761 cagccaaaga ggaagaaaaa gtagaccagg cttttattga aaaagaagga cagatttata 1019821 tggagaggat ggaaaaggag cgagaacgcc gcagttctca gcagcatgaa gaagaaaatc 1019881 aaaaccattc catcgcataa aaaaagctgt gcggctcaat gagccgcaca gcttttttta 1019941 ttatttagaa ttgcttgaag atgaagaagt gctgttgctt gttgaagatg tattaaatgt 1020001 gtctttcaga tctttatctt ttacttcgat gtcagccttc ttcatgactt tttgaacagc 1020061 ttcctgaaca gctgcgttgt catttaattt ttgttcaagc acttcagatt tcagttcttt 1020121 tttcatatca tcatatttgc cgcgttcttc tgtcttttta atgatatggt agccgtattg 1020181 cgttttgaca ggatcactga cttcacctgt ttttaatttg aatgcagctt tgctgaatgt 1020241 ttcgtccatt tggccttctt ttgcgaacca gccaagatcc ccgccttttg aagcagagct 1020301 gtctgttgag tattctttcg caaggtcttc aaacttctcg ccttttttca gctttttctc 1020361 tacttcttca gctgtctttt tatcagcaac aaggatgtgg cttgcacgga ttttgccttt 1020421 taagccttcc cagtactctt tgatatcggc gtctgttact ttgatgttat ctttagccgc 1020481 tttttgtgtc agcaattcat attttacttg ttctttcagg taatctttgc catattgctt 1020541 ttcgagggca gtatattgat cgccaagctg cgttttgtat tctttcagct tgttgtcaat 1020601 ttctttatcc gaaactttat acttcttgtc caatactttt tcttgcacta gctgtgtcag 1020661 tacgcttgcg ccagctgttt tcttcatgtt tgtgtaaagc tcgccttttg tgacatcgcc 1020721 tgcgtctgtt tttgcgataa cttctttgtc gccgctgctg caagcactga gagcgaggat 1020781 gcttgtagca gtgatagctg ctattgcgat tttcttcatt gttttcaaac actcctaatc 1020841 attccaaatt aaattaccta tgcgtatcat aacatattgt ggctttctgt aaaaagattt 1020901 taaataaagg gcattcgtct agtcaaactt ttgctgatga catacttata tattgatcaa 1020961 gaaaaggagg tatgtaacat gagcggagga tactctaacg gattcgcgtt gctcgtagta 1021021 ctgttcattt tgcttatcat cgtaggtgca gcttacatct actaagcagc ccgaggatcg 1021081 cttgcaacat aagcgatcct ttattttcac tagcgcctaa tcgtttcaaa catgaattgc 1021141 ataacatgta attggtaaat aaagcttatt acaggaggtg ctatttaaga tgggtgaagt 1021201 atttgcaggc ggattcgctt tattggttgt gttatttatt ttattgatta tcatcggcgc 1021261 ttcttggctg tactaatcaa cataaaaaag catagctgct taatcagcag ctatgctttc 1021321 tttcgtattt acactgtaaa ggagatctcc acaaacgaag agatcagtaa aattaatata 1021381 gatacattaa taaatcggaa taccttatct tgccgctctt caggaatctc tctgacaagg 1021441 cataatgtat tggtgagcct gtttatgaaa tataaaataa acacggcagc cacgataaaa 1021501 tagaataaaa tgatgggaga ttccccctct ctctgaactg tcccatatta cattaccaaa 1021561 tatttattaa aaaagataga atgcaaattg aaaaatcgcc accagcacca gggtttgact 1021621 acttttcaac aagaatatcc aagccgtcag cttcctgatc aataaaagcg gttttcggtg 1021681 cttttatcag cttgagagcc agcaggaaat caggcagaca gtagccggcg tgaatgcccg 1021741 agatcatgca aaaataatga gcgtgattcg gaaatgccag tgctgcgtaa aacaataccg 1021801 gtgtaatcag caagaacggg ctgacgagtg aaatcagcat tgttgttttt ggtatacgtt 1021861 tccatgtgcg catgcgcaat atgtaaaact ttttttctat ttttcttttt ttgcagatga 1021921 ttggcaggac atggatgact ttatgtacaa ataaaataac gacgagcaaa ccgccgaata 1021981 aagatacata ttcatcgctt aagcttgtgc caggccgcag cagctcaaaa gctaaaaagg 1022041 tagatataaa aaccaaaatc ataaaacata cagcagttaa tattatgcga acggcgccat 1022101 aatccttcat gagatttatg gtcttccagc aattcatcaa agtcatcctt ccatacatct 1022161 tgaatagaat ctcaaaataa tttactcctc ccaagagaaa aaatcaatgc ttttttaaga 1022221 aaaaatatca tccggcaggt atttttttga aacaagcaaa caaactgcga aatatggggt 1022281 tagaactttc ttctcagtga attatcagct aaaataagat taaagataga aagaagtggt 1022341 gtggatggat tcgatggatc atcgcattga gcgattagaa tattacatac aattattagt 1022401 gaaaacagta gatatggaca ggtacccctt ctatgcgctt ctcattgata aagggctgag 1022461 caaggaagaa ggggaagcgg ttatgaggat atgcgacgaa ttgtcggaag agctggcaac 1022521 acaaaaagcg caaggatttg taacctttga taagctcctt gcgctttttg ccggacagct 1022581 gaatgaaaaa ttagatgttc atgaaacaat ttttgccctg tatgagcagg ggctttatca 1022641 agagctgatg gaagtcttta tcgacatcat gaagcatttt gattaactgt ttacaggttc 1022701 gagctcttca gccggttcat ccgccgcact gtcctttgct tttttcttca attttccgtt 1022761 tacgctttca aagtcattgt caatattggt gagtgacgtt tcgaaaattt ccataaaatc 1022821 atcgccgtag atatggcgta tcatacacat catttctgcc acttcaggaa attttccgaa 1022881 taaatgatat aaaggctgtg accctttaaa aacagcgttg cgtgtcggat caaattcctc 1022941 aagcaagctc cagaatacct cggtaccttc ctcagtcaat tggacatatg tgttccgttt 1023001 atcattcagc cgtttggaga accttaaata tccccgttct tccagctttt ttgaaaagtt 1023061 gaatgcggtt gatacgtgca tgaccccgaa tttcgcgatt tcagaaatgg aagctccatt 1023121 caattgatac gcaatccata aaatatgatg ctcattaata ttcaggtcat acggtttgag 1023181 ccattgctgc caatccttct cgatcgattt ccaaagagcc ttgctaagct gagccatttt 1023241 ctgggtgaaa accagagctt ctttcacatc atagggcggt tccactcgat tcattacgtc 1023301 acctgcttct ctttttcttt ttctctatta tgccaataaa ataaagatta ataaagatga 1023361 aaatgtaaga attttttaat aaattcacaa accattgcga cgaaagggtt tttcggccaa 1023421 aaaaaatacg ggtccaattt tggcccgcat ttttttcttt tgaataggat attagttttg 1023481 taaggttttc tccagctgtc tgattttctc ttcgatatcg gcaatttctt tttgcagatc 1023541 ctgctggtga ggcttgatct cttcctgcca ttttttaatt gatgtttgga gctcgccgcc 1023601 cacgtcttta ataacatccg tgctttcttt tgccgctttg atcagctggt cttttaatgc 1023661 aagcccgtct gactttaagc gtttgattgt ttcttcaaaa gaatcataat tggttttcat 1023721 tttttcacgc agctgctttc ctgaggaagg tgcagtaaga agaaccgctg ctcctccgat 1023781 gatgccgcct acgaatagtc ctgttaatag agaacgtccg ctcgccatta caatcacccc 1023841 gtctttttct tcaaaatagg attcattcag catttttcat ttttgttgaa agcctgaact 1023901 tctatacata gcttgcttta ttttagcata ttttttaagt gaaaaggagg gagaaggttg 1023961 tctgtctttt tgattgtatt atcctgcatc acccttgcct tcgcttcagg cgctgtttac 1024021 tatatcaaac ttctcagcca ggctgcttct tatccgccca agagggttat ccggcagaaa 1024081 gcgcttgttt gttcaaccgg aaccgccttt acactatgtc ttatcttttt cacaaaactc 1024141 ctcgcttaaa acatgctgac atgctgcggg cgctctgttc aaaaaaacct ctcccggaag 1024201 cggaagaggt tttgtgtgac aattatttag cagcttccat aaagcttgaa cgccttaaaa 1024261 tggtttgcac aatcggataa ataatgatca ttgagattgt attcagcaca gcggccggca 1024321 gaacaacagc cgcgaacaat gcggcgaaac cgcccggtaa accgacgatc aataaagctg 1024381 acgatagaaa cacaattcct gataagatgg tcccgatcac tgtcagcaca gcggctgcac 1024441 ctgttttccg gctctttctg aacaagagaa acagggagaa gaacagaaac gctgatacgg 1024501 gtttatcaat gatgttaggg atctgtccgg ctggaaacgc ggttgtaagc gcggaaatga 1024561 ttccggtcac gatcccgatg acgagtacat tttgcacccg cgggaacagc agaatgccca 1024621 tgaacatcat gatcagcatc atatctggtt tcatgccgcc taaaaagggc ggaataatgg 1024681 aatgaagcgc tgcgccgatt gcggcaaaca gagccataat gactaactct tttgttttca 1024741 taactatgct ctcctctgct aagctttttg ccctccaata atatgctcat catttattgc 1024801 gaaggcttta cagaatgtgt tatgcaaaca gtataccaaa cggacggttt gcatagccag 1024861 actttttact cattttcctg ctggaatttc ttcatgaacg cagctaattt ttcacagtct 1024921 tcgagagaga ccgcgttata aatagaagcg cggcagcctc ccaccgaacg gtgtccgcca 1024981 aggccgatca tcttcgcatc ttttgctttc tgaacgaatg ttttcgttaa ttcgtcatcc 1025041 cgaagcgtga atgtgacatt catgcgtgag cggctgtctt ttctggcatg tcctttatag 1025101 aagccgttgc tttcatcaat acagctgtag agaacctgcg ctttttgttc attgcgctgt 1025161 tcaacagctt ccacaccgcc gttttccttg agccattcca gaacgaggct cagcatataa 1025221 atcgcaaatg tcggcggagt gttgtagagt gaatccgctt tgacatgcgt ggaatatttc 1025281 aagatttttg ggacgttcgc attttcattt tgcagccagc tttttttcat gatgactaca 1025341 gtcacgccgg aagggccgag gttcttttgg gcgcctccgt agatcacatc aaatttggac 1025401 acatcgattt ttctgcttaa aatatcgctg gacatgtcgg ctacgagcgg aattggagaa 1025461 ttcggaaact cctgccactg agtgccgaaa attgtattgt tggatgtgat atgtaaatat 1025521 gcgccgtctt ttacatccgt aaggtcaacc tctggaatat aactgtaatt gtctgtttca 1025581 cttgtagcgg tgatagacgt gttcccgaac agtttcgttt ctgccagtgc tttttcagac 1025641 caagcgccgg tcatcacaaa atgtgcggtt ttttcaggtg ttaaaaagtt catcggaagc 1025701 attgagaatt gaaggcttgc cccgccttga agaaacaaga tatcgtaatc ttccggaatg 1025761 cccatcagtt cgattaagag gcttttcgct ttttggtgca ccgcttcata ctctttgctg 1025821 cggtgggaaa gctccataac agacatgccg gattcgttaa aatcaataaa ttctttctgt 1025881 gctttttgca gaacttccag tggcagcgct gcaggacctg cgttaaaatt cgttgtacgt 1025941 tccattatga tctctccctg ttttccacgt taatgtataa aataatacaa ttatcctatc 1026001 acaaaaattc agttttttga taaaaaatta gaattatcaa aagaaattga cggatgtttg 1026061 cgaaatgttc acaaaataaa ataacctcat cttatgatga ggccaggcgt tttgcgatag 1026121 aggaagagat gttctgcaga tcctccggtt tataatcatc agcatgcgtt ttccaaaccg 1026181 ctccgaatcc atctcctttt ccgtagcgag ggataatatg catatggtag tggaacacag 1026241 attgtccagc tttttcgccg ttattgttca gcgtatttaa gccgatcggt tcaaattcat 1026301 cccggatagc gcgggcgatt tttggaacag catggaaata ttgttttgct aattcatctg 1026361 taaattcata tacattctca atatgtgttt tcggaatgac aagcgtatgg ccttttgtca 1026421 cttggctgat atcaagaaag gcaagtacat gttcatcttc atacaccttc gctgatggaa 1026481 tgtcgccggc aataatttta caaaagatac aattctctgc acaatgcatg agggttcctc 1026541 cttatgaaat tgtttagtat gtatacattc atcgtaccac agaaatgcag aaaatagaaa 1026601 acaggatgaa cggcgagcgt tcaccctgaa tgcagaggaa gagcttatat gaagaaaatg 1026661 tgttatgcct ttggtaagca cctcatttgt caataaaatg aagacttgtt taatgcctaa 1026721 cgattcctgc gataaacacc tcatttgaca atttgcttca tacatgaaga attcatcaat 1026781 tcagtgaaga gaaatggttt gagcattgga catgtttatt ttctatccaa ctgtttctaa 1026841 gacgtctttg acaaacacct catttttcag ttgatatgct tttcctctac aacttttatg 1026901 atgtccagaa ccctgtctct ttatgacagc aaattcatca tttgttaaaa gggaattgtt 1026961 tcaaatcagg ccttgttttt ggtactatga agaaaaacac tataagggga gaaactatgt 1027021 ctctgctatc ggtaaaagac ttgaccggcg gatatacaag gaatccggtt ttaaaaaacg 1027081 tatcattcac ccttgaaccg aatcaaattg tcggcttaat cgggctgaat ggtgctggta 1027141 aaagtacaac aatcagacac atcatcgggc tgatggaccc gcataaaggt tcaatcgaat 1027201 taaacggtaa aacgtttgct gaggatccgg aaggctaccg ttcacaattt acctatatac 1027261 ctgaaacacc tgttttatac gaagaattga cgctgatgga gcatcttgaa ctaacagcca 1027321 tggcatatgg actgtcaaaa gaaacgatgg agaaaaggct gcctccgcta ctaaaggaat 1027381 tccgaatgga aaagaggctg aagtggttcc cggcccattt ttctaaagga atgaagcaga 1027441 aggttatgat tatgtgcgca tttttggcag agcctgcgct ctacattatt gatgagcctt 1027501 ttctagggct tgatccgctt gccattaacg cgctgcttga acggatgaat gaagcgaaaa 1027561 aaggcggggc gagcgtgctg atgtcaacac acattttggc aacggcagaa cgctattgcg 1027621 attcgtttat tattttacat aacggcgagg tgcgggcgcg cggcacgctg tcagagctca 1027681 gagagcagtt tggaatgaag gacgcggcgc tggacgattt gtatcttgag cttacaaagg 1027741 aagacgctgg ccatgaataa tatgcttgat atttggcagt cgcggctgca ggagcatatc 1027801 aaagaaacaa gaacatacat gaaatatatg ctcaacgatc acctcgtcat tgttttgatt 1027861 ttttttctag cgggcgctgc aagctggtac agcaaatgga tacgggacat tcccgctcac 1027921 tttccgtcct tttgggtgat ggccgtgctg ttttcgctcg tattgacaag ctcttatgtg 1027981 cgaacgcttt tgaaggaggc tgaccttgtt ttcttattgc ctcttgaagc aaaaatggag 1028041 ccttacttga agcaggcgtt tgtctacagc tatgtgtctc agctgtttcc gctgattgcg 1028101 ctgagcatcg ttgcgatgcc gctttatttc gcagtcactc cgggagcttc gctcgtatcg 1028161 tatgccgcgg tctttgtcca actgttgctg ctgaaagcgt ggaatcaggt aatggaatgg 1028221 cgaacgactt tccaaaacga ccgcagcatg aaacggatgg acgtcatcat tcgctttgcg 1028281 gcgaatacac tcgttcttta ttttgttttc caatctgttt atatgtatgc gcttctcgtc 1028341 tatgtcatta tggctgttct ttatctgtat atgtcttccg cagcaaaacg gaaaacattt 1028401 aaatgggaga gccatattga gtccgaattg agacgaaagc agcgtttcta tcggattgcc 1028461 aacctgttta ctgatgtgcc gcatttgcga aagcaagcca aacgcagagc ttatctcgac 1028521 tttttgctgc ggcttgtgcc gtttgaacag cgcaaaacat ttgcctatat gttcacccgc 1028581 gcctttttgc gttcgagcga ttatttgggc attcttgtca gattaacgat cgttttcgcg 1028641 ctgatcatta tgtatgtctc agccagcccg ctgattgccg cggttttgac tgtgtttgcc 1028701 attttcatta cgggcattca gcttctgccg ctcttcggtc actttgacca tctggcgctt 1028761 caagagctgt accctgtgca aaaagaaaca aagctgaaaa gctatttctc tctattaaaa 1028821 actgcactta gtattcaagc gctgctgatg tctgttgcat ctgcctatgc agccggcttg 1028881 accggttttc tgtacgcgct gatcggttct gccgttctga tttttgttgt tttgcctgct 1028941 tatatgacga ccaggctgaa aaagcacgga aagctgtgaa ctgaaaagag gtaatcaaat 1029001 gacagataat cagctgctga tgcaggaagc tttggaatgg aaaatgcatt ttttgcgaaa 1029061 ggattccatg tttgaacgct tttcgaagcg tgtccagacg aaggtgaatg aacggattcc 1029121 tgaaaaaatc catacggtcg tcaccgagag tgtgaaaaaa atggtagaag cgacaatggc 1029181 cggctctaat atcatcacct ataaaaagga tacaagtgca ctgtcgctca gtgaaaaaaa 1029241 cgaattggcg aaaaaaacga ttgtttctta tcaaaaagtg gcagctgctg agggagtcgg 1029301 caccggagcg ggcggcattt ttttaagcat tgctgatttt ccgctgctgc tttcaattaa 1029361 gatgaagtgt ttatttacct tgtcttccat ttacggcttt gatgtcaagg atgcacaaga 1029421 aaggatattt ttgctgctcg tgtttcagct tgcgttttcg agtgatgatg gccgtaagtc 1029481 gcttttttct gtcatcgaaa attgggagac ggagaaaaag agcatcgact ggagagtgtt 1029541 ccagcaggaa tatcgcgatt atatcgacgt cgtgaagctt tttcagcttt tgccgggcgt 1029601 aggagcggca gtcggcggaa ttgccaatta taagctgctt gctcagcttg gagaaacggc 1029661 aagacatgtt tttcatctga ggatattaaa ggaaacagcc ggagaataaa cactccggct 1029721 gtttttttat agctgatgat aggtgatcgc agcgccggca aggaccttgg ccgctgtcag 1029781 catggctttt tcgttgatat caaatttcgg atggtggtgg gaatagactc gctctggctg 1029841 ttcgggagcg gcgcctgtaa agaaaaaagt gcccttcacg ttttgtaagt aataagcaaa 1029901 atcctcgccg cccatttgtg gttcaccgtc aatgacctgc tgaacgccct cggtattctt 1029961 tgcggtgctc accaagtggt tcgtttctgc aggatggttc acaaccgctg gataaccctg 1030021 ttcataggtg tactcatagg acgcgccgtg catgctgcat attcctttta caaccgcttc 1030081 aatttctttc tccagaatgt cccggacatt ttcatcaaaa gaacgcgctg tgccgatgag 1030141 tactgcttgg tctgcgatga cattaaacgg attgtcggcg atgaaggagc ctgtcgaaat 1030201 gacggcggat tgaatcggat tgactttgcg gctgacaatg tgctgcaaag aggaaacgat 1030261 ttgcgaaccg attaggacgg cgtctttagt atcatgcgga tgagcgccgt ggccgccctt 1030321 tccgaagact ttaatcgtaa atcggtctgc cgccgccatt acggcgccgg ggcggcagag 1030381 aatagttccg agcggctcag ttgcccaaag atgagtgccg aatatcacat ccgtgttttc 1030441 gagacatccg tcatcaatca ttggctttgc gcctccagga taatattctt ctgcatgctg 1030501 gtggatcatc acaaatgttc ccttcagttc atgtctgttt tggtgaagga ccttggccac 1030561 tgcgagaaga gctgcggtgt ggccgtcgtg gccgcatgca tgcatgacac caggcacttt 1030621 ggaggcgtaa gggacatctt tttcatcttg aatggggaga gcgtcaaagt cggccctcaa 1030681 agcgactgta gggccgggtt cgcttccttc tatatttgct aaaacccctc taccgccaac 1030741 gtttgtgcgg attgggactc ctaacgattc ataataggaa gcaataaatg cggcggtttt 1030801 ttcttcttga aatgagagct caggatacat atgaaaatgg cgcctgatct caaccatttc 1030861 ttcaaaacag ccgtcgagct gtttgtttat ctctttctgc agtgtggata tggacaaagc 1030921 cgcttccccc ttttctatgc ttttccatga ttgtatagaa aaagtctgaa tatttcaact 1030981 catgctgttt taaagcatca tcacagctgc gagggttgtc accaaaaggc caatcgcgac 1031041 gggaatgaag ttttttctgg caagctcaaa aggatcaact ttgcaaatgg ccgcggcggg 1031101 aatcaaagcc catgggacca gtgttcctcc gcccacccag atggcagaga tttgtccgag 1031161 cgcggtcaga atagcgggat cggcatggag agcggacgaa aagagctttg cgatggagcc 1031221 ggcgagagaa atgccagaaa atcctgagcc gtcaaggcct gttatggctc cagcggcagt 1031281 taatgcagtg gcggcaagct cctttgacat aggcatcata tgggataaag caatgccaag 1031341 atcgttgaca atgccgtggg aacctttagg gagtgaagtg cccagtatgc tttcatagcc 1031401 tgagtcgcca agataaaaga aagcggcaat cgggatgacg gggccgaaaa ccttaaaacc 1031461 gaacttaaat ccgtcaataa aatagccggt gattttttca agccctttat gcttatacac 1031521 gaaaaaatga acggtaaaga ggatacaaat tgcagacccg ccaattaacg cggttgcatc 1031581 atttccttgt aggttaaaca agagcatgca ggcgatatct gcaagaaagg caagcggaat 1031641 caaaaaagcc agtatggacc gcaggcgttt tggcaagtac agcgagttgt cttgttcgcc 1031701 ggaaagaacg ggggaaaaag aagtgggatg ctcctgtttt ttgcgttcgc gctgaatcat 1031761 gataaaggca gcagttgttg ttgtcacacc cataatcagc acaagcggaa tactggccga 1031821 gacgacatca ccgactggaa tgcctgctgc atccgcagtc agctttggcg ccgcctgaat 1031881 gacaaagtct cctgacaggg caaaaccgtg tccgaataag ttcatggcca tggccgcggc 1031941 aagaggcgtc aaaccggcac gtgcggctgc ggggagcagg acggcgccga tcaaagcgac 1032001 acccggagaa ggccagaaga atagagaaat ggcgaacatc aggcctccaa tcagccaata 1032061 ggcagtcaca ggccctctca caaggcttgc aaagggagaa atcatcgctt catttatccc 1032121 tgtttttgtt aacaaatcac tcattgaaac gataaagcaa atgatgaaaa tcgtgggcag 1032181 cagttcgccg gccgcataga taaagctgtg gaataaactg ctgacagaag ctgaaagtga 1032241 atggctggcc catagcgata tgataaaaat gccgaataga gaaataaatg tcgtgtcttt 1032301 tctcagcagc ataaatagga taattgcacc gataaaaaac acatacagaa catggacagg 1032361 caaaatcccg acttccatca tcgatcactc cttccgctta cagattattc ataggcgggc 1032421 ggaaggtgcc gggacagagg ggagggttat gatggaagat gaacattgat ctgtttcagc 1032481 tgctcaatca gatgatgcct taatcctcta ttcgcttttt gcagatgttt tgggaagcat 1032541 tcaggagaaa aaatgacgca cccttcagca agccagtttt ttctataggc gatgatgctt 1032601 tccgatggct ctatatgagt tatcctcgtg ctgcatctcg tactcatcaa atccgaactg 1032661 aaaaccgcag cacgggcaga tttcatgaga atgattgcct tcatgatcat atggcggttc 1032721 agccaatcct taaacccgca gactgggcaa gtatgcttca ttttgctttc ctcccaataa 1032781 aataagctgc cggacatgcc ggcagctatt cgacagcgaa atatgtggtg acataggaag 1032841 gccgggagaa gatcgacgtt gtgtcaattc cggcagatgt atcgcgtttt ttgtgggctt 1032901 ctttgtaaga accggactgc tgccagtctt gaaaggcgct ttccgtttcc cacaaggtca 1032961 gaatgacata ggtgtcactg tcaagcggac ggagcactcg aattgcttca aagccaggct 1033021 cgttttcgac ttttcccgct ctgtttttaa atctgttttc aaacagcgga cgcccttcct 1033081 gagtaacggc aatattgttc aatactgcaa aaccgggatg tttgatctct ccgacttggt 1033141 caatgacttc ataagcgtgt ggtgcctgga aaacggtatc tccgtttgtt tcatgaatta 1033201 aaatggcgtt ttcctgcccc tgcatcaaaa ggatattttc tgagggatgc ttctgtacga 1033261 tcgtttttaa aaaatcggct gtcccatatg taatataaac cttcatatca gccacctcct 1033321 gcttgctagt atatcaaaac aatggtataa gtttctattg gcgagtgctt cgaacataat 1033381 tccaaacaat ttttcccata ctacctttag aaaggcgagg tgagttcatg tttaagataa 1033441 agaaaaagaa actttttata cctatcatta ttttagtgtt aactgctttt ctcgctttaa 1033501 taggatatat ttcaattatt tttctcggcc attatgtcat agatgaaaaa aagcttattc 1033561 ttcatgcttc ttcaaaaatt gttgatcaaa acggagatga ggttgcaagc ctgtatacag 1033621 aaaatcgcga gccggtctcg atcaatgaga ttcctaagca ggtcagagaa gcgtttatcg 1033681 ctgttgagga taaaaggttc tatgagcatc acggcattga tgcaaaatcc gtcggaaggg 1033741 cagtgtaccg cgatatatta gcaggcggaa aggtggaagg cggaagcacg atcacccagc 1033801 agcttgccaa aaatattttt ctgacacatg acaaaacatt tctaagaaaa acaaaagaag 1033861 tgatcattgc gattaatctt gaacgggatt acagcaagga caagctgctt gaaatgtatt 1033921 taaaccagct ttacttcgga cacggggttt acggcataca agcggcgtcc cactattatt 1033981 ttaataaaga agtaaaagat ttgactgtat ctgaaggcgc tgttttggcc gctattccga 1034041 aggcgccttc tacgtactct ccaattttgc accctgataa aaataaggag cggcgtgata 1034101 caattctagg tatgatgaat gaccaaggct atatcagtgc gaaagaggct gtcaccgcac 1034161 agggccggac gcttggactg catgtgaaga aacagtcgga aacaccttgg tttgacagct 1034221 acattgacct tgtgatcaaa gaggcggaag acaagtattc catttccgga gagcagcttc 1034281 ttcaaggcgg atacacgatc aaggtgccgc tcgattcgaa gctgcagaag acggcttacc 1034341 aggtgatgaa agagggaagc tattatcccg gaacagatca gaatgccgag ggaagcgcgg 1034401 tctttattaa taacaagaca ggcggtgtag aagcggccat cggcggaagg gattacacat 1034461 ccaaaggata taaccgtgtc acagctgtcc gccagccggg ttccacattt aagccgcttg 1034521 ctgtatacgg accggcgatg caggaaaaga aatttaagcc atattctcta ttgaaggatg 1034581 agttgcagtc ctacggagat tatacgccga aaaactacga cagccggtat gagggcgaag 1034641 tcactatgtc tgacgccatt acgtacagca aaaacgcgcc ggctgtctgg acgctgaatg 1034701 agatcggcgt cgaaacaggg aaatcttatt tgaaagcaaa cggcattgat atccctgatg 1034761 aaggccttgc tcttgctcta ggcggcttgg aaaaaggcgt ttcaccgctc cagcttgccg 1034821 gcgcgtttca tacatttgcc gcgaatggaa cgtatactga acccttcttt atctcgagca 1034881 taatagatga agacggagaa acaatagccg atcataaaga agaaggaaag cgggtattca 1034941 gcaagcagac gtcttggaat atgacgagaa tgctgcagca ggtagtcaaa aagggaacgg 1035001 ccacgtccgg cacctatcac ggcgacctgg cgggaaaaac aggttcaaca tcttatacag 1035061 gcgtctccgg cgcgacaaag gacgcctggt ttgcaggcta tacgccgaaa ataaccgggg 1035121 cagtctggat gggctatgac aaaacggatc aaaaccatta tttgaaagcc gggagctcat 1035181 acccgacgcg gctgtttaag gatattttga cacaggcagg agaaaccggt catgtgttca 1035241 caaagcctaa aaacgttaaa gaactggaaa gcccgattga gctgaagccg gtcaaaacac 1035301 tcacagccga ttacacattt aaagcagcgg ggctctttac tattgaatta aagtgggacg 1035361 ctcaagagga tgatcgggcc gtatacagaa tttatgtaaa caaggacggc gaggagacgc 1035421 ttcttgattc ggttgaaggg aagggaagct atgaaattcc ttatgccaac ttattttcgg 1035481 gcgcgtctta taaaattgtg ccttataata cacagacaaa aagagaaggg gaaggaaccg 1035541 attacgttca gccaaaattg ttttcctctt aatggaattc ggcgattttt tgaactttga 1035601 gctacatttc tataccattt gcctaaaaca aggtatagtg taataagtca agaaatacga 1035661 acgtatggtt gccgtatgaa aggtggaaat cagatgagta aacgagaaac gtttaacgag 1035721 acgtttttaa aagctgcgcg gggagaaaaa gcggatcaca cgcctgtgtg gtatatgagg 1035781 caagcagggc gctcacagcc ggaataccgc aagctgaagg aaaagtacgg attgtttgag 1035841 atcacacatc agcccgaact ttgtgcgtat gtcacaagac tgccggttga gcaatacgga 1035901 gtcgatgctg caatccttta taaagatatc atgacgccgc tgccgtcaat cggtgtggat 1035961 gttgaaatca aaaacgggat cggtcctgtg attgatcagc caatccggtc tctggcggac 1036021 attgaaaaac tcggccagat tgatccggaa caggacgtgc cgtacgtgct tgagacgatt 1036081 aaactgcttg tcaatgagca gctgaacgtc ccgctcatcg gtttctcagg tgcgcctttt 1036141 acgcttgcaa gctatatgat cgaaggcggc ccgtcgaaaa actacaataa aacaaaagcc 1036201 ttcatgtaca gcatgccaga tgcatggaat ctgctgatgt ccaagcttgc cgacatgatc 1036261 atcgtgtacg tgaaagcgca gattgaggca ggcgcaaaag cgattcaaat ctttgattcg 1036321 tgggtcggcg cattgaatca ggcagattac agaacataca tcaaacccgt gatgaaccgg 1036381 atcttttcag agctcgcaaa ggagaatgtg ccgctgatca tgtttggcgt tggcgcaagc 1036441 catcttgcag gtgattggca tgaccttcct ctcgatgttg tcgggcttga ctggagactc 1036501 ggcattgatg aagccagatc aaaaggaatt actaaaacag tgcagggcaa cctggacccg 1036561 tccattttgc ttgcgccatg ggaagtcatt gagcagaaaa cgaaggaaat acttgatcag 1036621 ggtatggagt cagacggctt cattttcaat cttggccatg gggtatttcc tgatgtcagt 1036681 cccgaggttt tgaaaaaact gacagcattt gtccatgaat attcacaaaa caaaaaaatg 1036741 ggtcaatatt cctaagcata tcttttggta tcttaatgat atcctgtcaa aatgtttgta 1036801 tcagatcatt aaagagggtg taaacagtga gtagaaagaa aatggggctt ctcgtgatgg 1036861 cgtacggcac gccttataag gaagaagata ttgaacgtta ttatacacat atcagaagag 1036921 gcagaaagcc tgaacctgaa atgcttcaag atttgaaaga cagatacgaa gcgattggcg 1036981 gcatttcacc gcttgcccaa atcacagaac agcaggcgca taatctggaa cagcacttga 1037041 atgaaattca ggatgagatt acgtttaaag cgtatatcgg actgaagcat atcgagccgt 1037101 ttattgaaga cgccgtagca gagatgcata aggatggcat tacagaagca gtcagcatcg 1037161 tgctggcgcc gcatttctcc acgttcagcg ttcagtccta caacaaacgc gccaaagaag 1037221 aggctgaaaa actcggcggc ttaacgatta cgtcagttga aagctggtac gatgaaccga 1037281 agttcgtgac atattgggtt gaccgagtga aggaaacata tgcgtcaatg cctgaggatg 1037341 aaagagaaaa cgcaatgctc atcgtatccg cacacagcct gccggaaaaa atcaaagaat 1037401 ttggagaccc gtacccggac cagcttcatg aatcggcgaa attaattgct gaaggcgcag 1037461 gcgtttccga atatgctgtc ggctggcaaa gtgaagggaa cacgcctgat ccttggctcg 1037521 gacccgatgt tcaggattta acacgtgatt tattcgaaca aaaaggctat caagcatttg 1037581 tatatgttcc tgttgggttt gtcgcggatc acttagaagt gctttatgat aatgattatg 1037641 aatgcaaagt ggttactgac gatatcggcg caagctatta ccggccggaa atgccaaatg 1037701 ccaagcctga atttattgat gctttggcaa cagtcgtatt aaaaaaatta ggacgttaaa 1037761 gaaggcgatg aacatgagtg acggcaaaaa acatgtagtc atcatcggcg gcggcattac 1037821 cggtttagcc gccgccttct atatggaaaa agaaatcaaa gaaaagaatc tgccgcttga 1037881 gctgacactt gttgaggcaa gtccgagagt cggcgggaaa atccagactg tcaagaaaga 1037941 cggctatatc atcgaaagag ggccagactc atttctggaa cgaaagaaaa gcgccccgca 1038001 gcttgttaaa gacttaggtc ttgagcattt gcttgtcaac aatgcgaccg ggcaatccta 1038061 tgtgcttgta aaccgcaccc tgcatccaat gccgaagggc gctgtaatgg ggataccgac 1038121 aaaaattgcg ccgtttgttt ctacgggtct gttttccttg tccgggaagg cgagagctgc 1038181 tatggatttc atcctgcctg caagcaaaac aaaggatgat cagtcattgg gagaattctt 1038241 ccgcagacgt gtcggagatg aagtggtcga gaacttaatc gagccgctac tatcagggat 1038301 ctacgcaggc gacattgaca agctcagcct gatgtcgaca tttccgcaat tttatcagac 1038361 ggaacaaaag catagaagcc tgattctcgg catgaaaaaa acaaggcctc aaggctcagg 1038421 ccagcagctg acggcaaaaa aacaagggca gttccaaact ctgtcaaccg gtttgcagac 1038481 ccttgtagaa gagatcgaaa agcagttaaa gctgacgaag gtgtataaag gcacaaaagt 1038541 gaccaaactt agccatagcg gctcttgcta ttcgctcgaa ctggataacg gcgtcacact 1038601 tgatgctgat tcagtaattg tgactgctcc gcataaagcg gctgcgggaa tgctttctga 1038661 gcttcctgcc atttctcatt tgaaaaatat gcactccaca tccgtggcaa acgtcgcttt 1038721 aggtttccct gaaggctccg tccaaatgga gcatgagggc acgggttttg tcatttcaag 1038781 aaacagtgac tttgcgatca cagcctgtac gtggacgaat aaaaaatggc cgcacgcagc 1038841 gccggaaggc aaaacgctgc ttcgggcata tgtcggaaaa gccggagacg aatccattgt 1038901 cgatctatca gataatgaca ttatcaacat tgtgttagaa gacttaaaga aagtcatgaa 1038961 cataaacggc gagccggaaa tgacatgtgt aacccgatgg catgaaagca tgccgcagta 1039021 ccatgtcggc cataagcagc gtatcaagga gctgcgtgaa gcacttgcat ctgcgtatcc 1039081 gggtgtttat atgacaggcg cttctttcga aggtgtcggc attcccgact gcattgatca 1039141 aggaaaagct gccgtgtctg acgcgcttac ctatttattc agctaaaacc tccgctttat 1039201 cgcggaggtt tttttgatgt gcaatggcaa tattgtgtaa aaaatgattg aattgaacag 1039261 caggttatga tacatttgca tatgtactta atgactaaaa tgttcaaacg gtcagtttcg 1039321 aggtgaatac aatgtcaata gatcgaaaaa agctcatttt ggaggcggct acaaagtctt 1039381 tcacgcagtt cgggtataaa gcgacgacaa tggatcttgt cgcaaaactt gcgaacgtgg 1039441 ggaagggaac catttatact tttttcaaaa acaaagaaga gctgtttgac gagattttca 1039501 ctactttatt aaaggaaatg aagcaaaaag cggatgaagc gatggagccg agccttccgt 1039561 tccatgaaaa tgtgcacaga gcgctgtttg ccattctgga gttcaggaaa acacatcagc 1039621 tgacgattaa aattttccaa gagaatgccg agattggtac aatggcagtt caggaagtga 1039681 tccagaaaat ggagcgatcc atcctgtctt atatcaaaag caagattgaa gacgggatca 1039741 aaagcggcgc aatcaagccg tgcgaccctg agctgacagc ctttgtgatg ctgaagcttt 1039801 atatcgcgct catttttgac tgggaaaaac aacacccccc gcttgataaa gagacaattg 1039861 cgggactgct tgaattgtat gttgtcaaag gattgtcagc gaactagata atcctttctc 1039921 tttgcaagaa aatgaccatt ttttatgatg agtcagtttt agaatggagg catcaggatg 1039981 aacacaatac gaagtcagtg gaaagacatc gtaacaagta aaaaattatt gattcccatc 1040041 atcgccattt tgtttgtccc gcttatttac agcggcgtat tcttaaaggc ttattgggac 1040101 ccgtacggca cagttgacca gctgcctgtc gttgtcgtca accaagacaa gggagcaacg 1040161 tatgaaggag aaaaacttca aatcggtgat gatctggtca aagaattaaa ggataataac 1040221 aactttgatt ggcatttttc caatgatctc gaccaatcgt taaaggactt attgaatcaa 1040281 aaatattatt tagttgtcga gattcctgag gatttttcta agaatgccag cactgtatta 1040341 gacaaaaatc cgaaaaaatt ggatctgaaa taccatacaa atgcaggttc taactatgta 1040401 ggggcaacga tcggcgaaaa agcgattgat aaactgaaag cctctgtttc aaaagaagtg 1040461 accgagcaat atacgaaagt tatttttgat aactttaaag atatcgcaaa aggtttgagc 1040521 gacgcgagca gcggcgcgaa aaaaattgat gacggcacaa aggatgcgaa aaacggaagc 1040581 gcccagctga aagaaaatct ggcgaagctg aaggaaagca ccgctaccat cagtgacaaa 1040641 acagcgcagc ttgcagatgg agcggctcag gtgacgagcg gcatccaatc acttgacagc 1040701 tcgctcggta aattccagga cagcagcaac cagatttatg ataaatctag tcagcttgca 1040761 gcaggatcag gcgagctgac aagcaagatg aatgaacttc ttgccggact tcaaaatgtg 1040821 cagaagggta cgcctaatct tactaacggg ttggatcagc tcaacagtaa agtccaagaa 1040881 ggttctgaga aagcggcaaa agcggaaaag atcattaatg cgctcgattt aacgaagctt 1040941 gaaactgctg taaacaatct ggaaaagtca gaaactgcga tgaaggaatt caaaaaacag 1041001 ctgactgact ttgaaaacag tttgaaaaac cgtgatcagg catttaaaaa tgtcatcaat 1041061 tcgagtgact tcttaacagc ggagcaaaaa agccagctga ttaattctgt tgagaaaaag 1041121 cttccgcaag ttgatgcgcc tgattttgat caaatattaa gccagctacc tacagctgat 1041181 cagctgcctg acatcgcaac gataaaaagc tctcttgaag acgtgaaagc gcaggtggcg 1041241 caggtgaaag ccatgccgga agctacatct aagctttata acggcgcaaa aacaatccaa 1041301 gatgcgattg acagattaac tgagggagct gataagatat acaacggttc tcagaagctg 1041361 acagatggcc aaactaaact gacagcgggc atcggtgaat ataataagca gttcgcaaaa 1041421 gcaaaagcgg gctcagagca attggtgaca ggaagcagcc aagtatccgg cggattgttt 1041481 aagctgttag acgggtctaa acaggtccaa agcggatcat caaaacttgc agacggatct 1041541 gcatcacttg atacaggttt aggcaagcta ttggacggca caggagagct gtctagtaag 1041601 ctgaaggatg cggctgacca aacaggagat atcgatgctg atgatcaaac atacggcatg 1041661 tttgcggatc cggttaaaac caaagatgat gccattcatt ccgttcctaa ctatggaaca 1041721 gggctgacac cttatatcct gtcaatgggc ttgtatgtcg gcggcatcat gctgacggtt 1041781 gtcttcccgc tgaaggaagc gtcaggacgt ccgagaaacg gttttgagtg gttcttcagc 1041841 aaattcaatg tcatgatgct tgtaggaatc attcaatcat tgattgtggc gacggttctt 1041901 ctattgggaa ttggtcttga ggtagagagc acgtggagat tttacgtgtt tacgatcatt 1041961 acgagtctcg ctttcctggc gataattcaa tttttggcta caacgatggg caacccgggg 1042021 cgatttatcg cagtcattat tttagtgctg cagctgggag cgagcggagg aaccttcccg 1042081 ctggaattgc ttccgaattt ctatcaggtc atccacggcg cattgccgat gacctacagc 1042141 attaacggat tcagagcagt catttcaaac ggtgactttg gctacatgtg gcagatggcc 1042201 ggcgtcttaa tcggcattgc cctcgtcatg attgcactaa gcattactta ctttacaatg 1042261 ttaagccgga aggaagaaac atcagaagaa cagccggctt cataaagaaa aagaacttgt 1042321 ttccttggaa acaagttctt tttttgttac atcccccatt taataagcaa tcctgtatag 1042381 gttaatccgc cgccaaaccc gaaaagcaaa acgatttgat cttttttcag cttcccggct 1042441 ttcactgcga gatcgagcgc caaaacaatt gaaaccgaag acgtgtttcc gtagtgctca 1042501 acactagtga gcgttttttc aatcgggaac ggtgtttttt cacaaattga ctcgatcatg 1042561 cgcaagttgg cgctgtgagg aacaaaccaa tcgagatcat cggagctgag tcctgcttta 1042621 tgtaaaagcc gttcaaattc gccagggacg gttcttgcgg cccatttata tacctcgcgt 1042681 ccgttttgca ccatttttcc ggaaccgaca agctgcacac cgtttatttc atttcgcagt 1042741 ccggcacgat acaaaatatc gccgccgttc ccgcttgttc cttgtacaga cgcaagaaat 1042801 cccggcgtct cttcatctcg ttctactaac agcgcacccg cggcatcgcc gaacagtacg 1042861 catgtcgttc gatcggtata atcggttacc tttgataacg tctctccggc gatgacgaga 1042921 attttttgat gaaggccaga tgtgatcaat ccatttgcca aatggaggcc gtatgtcagc 1042981 ccggcgcatg tcgcattaat atccagcgcg ccggtgcttt cccagccgaa atattcctgt 1043041 acgcggcatg ccgtactcgg aaaggcgtaa tcggatgtgg ttgtggcaac gaggatcata 1043101 tcgacatcat caagcgttcc tttataacgg ctcttgagat tcttcaccgc ttctatgcat 1043161 aaatcagagg taaattgatg ttcatccgca atccggcgtt ctctcattcc tgtgcgctga 1043221 acgatccatt catcagaggt atcaacgatc ttttctaaat ctgcattggt taaacgtctg 1043281 ctcggcgcat aggtgccgat agctgtaatt tttgcttttg acatatgaat cactccttat 1043341 ggtcagatta taacactaga tattagtatc tggtactaaa aagaaggttt ttttacaaaa 1043401 aaagagaagt gtagatagga atctatgaaa aagaaaaagg aggctgaaaa atggtcagtc 1043461 aagaagcagt agtctttttg gcattatccg gggctattgc gtttctgttg ccaatcgggc 1043521 tgattgtatg gtttaagcga aagtatggtg cctcgcttaa agtgtttttt attggcgctc 1043581 tcacgttttt tgtcttcgct cagctgctgg aaggcggcgt tcatgtttat gtactgcaag 1043641 tgaatgaaat gacgaaagaa gcgatgcagc atccattatg gtatggcatt tacggctgct 1043701 tgatggccgg catttttgag gagtgcggaa ggtatttgat gatgcgattt tttatgaagc 1043761 gccatcatac ttgggcagat ggtctggctt tcggggcagg ccatggcggg cttgaagcca 1043821 tcctgattac aggcttgtcc tctatctcac ttattgtata cgcatttgca atcaatagcg 1043881 ggacgtttga acagcttttg gtcaatggcg acgtcaaaca ggcgcttttg ccgatacagg 1043941 agcagctgct gcatactcct tcgtatgaat ggatgctggg cggaatagaa agaatcagtg 1044001 ccattgccgt ccagattggt ctgtctctgc ttgttttgta cgcggttaaa aaccgccggc 1044061 cgctgttttt gctgtattct attcttttac atgcactgtt taatgtcccg gcggttttat 1044121 atcaaagagg aatcatagag catgctgcag ctgttgaaat cattgttgct cttatagcgg 1044181 ctttatcagt ttattggatt gtaaaagcaa aaagggtgtt tcaataaaag gtccaagcag 1044241 cagcaatgcc cgcttggaaa aatgtgaatg gaaatattca ttaagcatgg gtcatcagaa 1044301 tatttctgat tcagtcttta gcaatgacag caagaatgtc tgtgtttttt acaagagaaa 1044361 caatggtgtt tctttttctt cttctcgcaa gggtcatggc attctttctt tttcttgcaa 1044421 tggtcgtgga aatctttatc gaaccactcg tcaaagaacc aaaaatcatc gaaccaatcg 1044481 tgacaacgac atttctgttc atgtgaatga cgacagcaca tagaaatccc tcctcttccc 1044541 atgctctcta cagcatatga gagattgata ggaaaagatt ggacgggtcc ctcgggaaaa 1044601 gagtatattt taagtagaaa ataaaaggag gaatgcccta tgacgtccgt acgtaaaacg 1044661 atggagctca ttaaagaact tgtatcgatc ccaagcccga caggaaatac atatgaggtg 1044721 atcaattata ttgaaagcct tttaaaagaa tggaaggtag aaacggttcg gaaccacaag 1044781 ggcggcttaa ttgcaacgct tccaggacgc gacacatccc ggcatcgcat gctgacagcg 1044841 cacgttgaca ccctcggcgc tatggtgaag gaaattaaag cggacggccg gctgaaaatc 1044901 gacttaatcg gcgggttccg ctacaactcg attgaggggg agtattgcca aattgaaacc 1044961 gcctcgggaa aaatgtacac aggcacaatc ttaatgcatc aaacgtctgt gcacgtatac 1045021 aaagacgcgg gaaaggctga gcggaatcaa gagaatatgg agatccgcct agatgaacct 1045081 gttcactgcc ggaaagatac ggaggagctt ggcattggcg tcggagactt tgtgtcgttt 1045141 gatccacgtg tcgagatcac atcaagcgga tttattaaat cgcgccattt ggatgacaaa 1045201 gcaagcgtcg ccttattgct ccgcttaatt catgaaattc aaacagaaga cattgagctg 1045261 ccgtatacaa cccattttct tatttccaat aatgaagaaa tcggttacgg cgggaattcg 1045321 aatattcctc ctgaaacagt tgaatatttg gcggttgata tgggcgctat cggtgacggg 1045381 caggcgacgg atgaatattc agtatcaatc tgtgtgaagg atgcgagcgg gccgtatcat 1045441 tatcagctca gaaagcattt agttcaatta gccgagaagc atcatattga ctataagctt 1045501 gatatatatc cgtactacgg gtctgatgcg tcagcagcga tcaaatccgg gcatgatatt 1045561 gtgcatggcc tcatagggcc gggaattgac gcttcccatg catttgaacg cacccataaa 1045621 tcatctcttc gccataccgc taagcttctg tattactatg tacagtcacc aatggtataa 1045681 gggggaggac caatgaagat ttataagctg aaaagcacat tcggttggga aggtgatgac 1045741 gggttgggag aacagctgat tcagcagatc cttgccggag aaaaaagcgc cacgtgcgcg 1045801 ccgaaatcat tgtattcaaa agatgaattg agggacgttt atcaaacagc gggtcagctt 1045861 gttaccgttt atgataaaca tgacaatcca agatgcaata taaaagtaac agatgtcttt 1045921 gaaaccacct ttggtgcgcc tgatatgagg ttagtcaaag gagagggcaa tggagaccga 1045981 attgaggagt ttcaagagga tcatcggatg gcatgggcgg aactgatcaa aagcggtgaa 1046041 ctggagctga atgaggatac tgttttgatt acagagttgt ttgtgcttgt taaagattaa 1046101 aaaagcctgc ggggcaagaa ccccgcaggc ttttcattaa ccagaaatgg ttgcgttttg 1046161 ttctgttttc gattgggaca taacagtttc tgctttcgca ggattaaaca tgccttccca 1046221 tttagacatc acaacggcag caagcgcgtt accagtcagg ttgacaactg tacgtgccat 1046281 atccatgatg cggtctacgc cggcaataaa ggcaagtcct tcagccggaa cgccgatggt 1046341 gccaagcgtt gcaagcaaga caacaaaaga agtaccaggt acggcagcca tccctttgga 1046401 tgtcaccatt aagacgagca caagcgtaat ttggtgccaa atcgtcaaat caatgccata 1046461 tacctgtgct aaaaagagtg cggcaataga ttgatagaga acggaaccgt ctaagttaaa 1046521 cgtgtaaccg atcggaatga caaatgaaac aatgcctttt ggacatccga ttttctccat 1046581 tttttccatg atacgcggaa gaaccgtttc agagctggac gtactgaacg ccagtaagat 1046641 ttcgtccttc atgtaagcaa ggaacttgaa gatgctgatg ccggcaattt ttgcgacaat 1046701 cccgaaaata acaattaaga agaaagcaag cgcgacataa accaatccga cgagctttcc 1046761 gagagagata agagaaccga gtccgaattt agacacagtc actccgataa gagcgaaaac 1046821 gccgaatggc gccactttca tcacaaggtt tacaacgtgg aacatggcat gggatacacc 1046881 ttcaaaaaag gctaatacag gcttgcctct ttcaccgatc gcggaaatac ccaatgcaaa 1046941 tagtactgta aagcagatga tggctagaag atccccttcg accaatgact ggaagaagtt 1047001 tgtcggcaca atatggagga acgtttccgc cactgattta ttactttgtt ctttttcagt 1047061 ttcaacatat tgactgatgt ccgatttttg agcttcgtgt atattaactc ctgtacccgg 1047121 atggaagatg tttgcaaggg ctagtccgag aataatggca aaagtcgtga tgatctcgaa 1047181 gtacagaatc gttctgaagc ctaatttacc gacttgcttt ccatttcctg caccggctac 1047241 accgatgatt aagctggaga caacaatagg aatcactatc attttgatta agcgtaaaaa 1047301 gagatccccg attggctgca ggtaagtagg caatgctggg ttgccatacc aaatgacgcc 1047361 aacaatgaca cctagaataa gtccaacgaa tatttgtgtg gctaatccaa acttaattct 1047421 tttcatagat tacctcccaa aaaacaaagt atcaacatat atcatgaata gacatatatt 1047481 taatctcact attagatcaa attataatag ataagaaatc aattcgtcta tagtaaatta 1047541 tatttcgaaa ataaagaata ttcaatgaca ttatgataat caccagaatt atctaaaaac 1047601 aggtgagctt tgacctaacc tgactattat ttcaaaatta agagatatgt gaaaaaataa 1047661 gaaaatccca cgcgtaaggc gcgggatttt cgctcattac aaatcgttta cttttataca 1047721 gtcattgcag atattaccat aacactcatg ctgctcttct atcttttttc cgcattccgc 1047781 acactttttc gaaggcaggt ttctaaaaaa ttctgtgatt ttccccagca taaccaatcc 1047841 ctctttcccc tttgtagtga tttcattgta atataacaga ttacaaaaat caataactgt 1047901 tttgatacaa tgtttaaaac atgctttttt caagaaaaat gggtatattg aaggaggacc 1047961 aatttttttg aaaagatagg aggacattat gaaagttaca gttatcggat gctatggcgg 1048021 ttttccggcc gcaaatgaag cgacgtcagg ctatttgttt cagtcaggtg attactctct 1048081 gcttgttgat tgcggcagtg ccgtattgtc taagctgttc ggatatgtgc cggcggaaaa 1048141 gctggatgcg gtcgttctgt ctcattatca ccatgaccat atcgctgata tcggaccgct 1048201 gcaatttgcc aagcaagtcg gttcgtttct cggcaaagga gagcatacgc ttccgattta 1048261 cggacatgat gctgatatag aacagtttca aaagcttaca tataaaacac atacaaaagg 1048321 gatcgcctat cagccggatc agccgctgac tgccggtccg tttacgatca cctttttaaa 1048381 aacgattcac ccggtgacgt gctatgccat gcggattact gacggcagcc acactgtcgt 1048441 ttatactgct gattccagct atcaggattc atttataccg ttttcgaaag atgctgattt 1048501 attgatctca gaatgcaatt tttatgccga tcaagacgga acaagtgcag gccatatgaa 1048561 cagcctggaa gctgggcgca ttgcaaaaga agccggagcg ggagaactgc tgctgacaca 1048621 tttgccgcat tttggcgtgc atgacaacct tcgcaaagaa gcgaaaaccg tttttaacgg 1048681 agaagtgaat attgcgaaat caggttttgt gtgggaagga taaaggagga gcaccatgtt 1048741 atttatagac aatcaaaata tcaatgatcc gcggatcaat cttgctatcg aggagtactg 1048801 tgtaaagcat ttagaccctg aacagcaata tttgctcttt tatgtgaatc aaccgtctat 1048861 tatcattggg aaaaaccaaa atacaataga agaaatcaat acaaaatatg ttgaggaaaa 1048921 cgggattatc gtcgtccgcc gtttatcagg cgggggcgct gtgtaccatg atctggggaa 1048981 cttgaacttc agctttatta ccaaggatga cggggacagc tttcataact ttaaaaaatt 1049041 cactgagcca gtgattcagg cgttacatca gcttggggtt gaagccgaat taagcggccg 1049101 gaacgacatt gtagtagatg gccggaaaat atccggaaac gctcagtttg caacgaaagg 1049161 ccgtattttc agccacggca ccctcatgtt tgattcagcc attgatcatg ttgtatcagc 1049221 attaaaggtg aaaaaggata aaattgaatc aaaaggcatc aaatcgatca gaagccgagt 1049281 ggcaaacatc agtgagtttc tcgatgataa aatgaccacc gaagaattcc gcagccattt 1049341 gcttcgccat atttttaaca caaacgacgt tggaaacgtg ccggagtata agctgacgga 1049401 aaaagattgg gagaccattc atcaaatttc gaaagagcgc tatcagaatt gggattggaa 1049461 ctacggccgc tcaccaaaat ttaaccttaa tcattcgaag cgttatccgg ttggatcgat 1049521 cgatttgcac ctggaagtca agaaaggcaa aatcgaggac tgcaaaatct tcggagattt 1049581 cttcggtgtc ggtgatgtat ctgaaattga aaacctgctg gtcggaaaac aatacgaacg 1049641 cagcgtcatc gctgatgtgc tcgaaggtgt gaatctcaag cattactttg ggaacattac 1049701 gaaagaggat ttccttgatc tgatttacta aggcaaaaca catcgtttga aagagcggtt 1049761 gtgtttttga aataatggag gcaggaggga ttcacatgaa agtgttttta atcggagcga 1049821 acggacaaat cgggcaaaga ctcgtctctt tattccaaga taatcctgat cattccatca 1049881 gagcgatggt cagaaaagaa gaacagaaag cgtctcttga agctgccggt gcagaagctg 1049941 tgcttgcgaa tctggagggc agcccggaag aaatcgccgc tgcggcaaaa ggttgtgacg 1050001 cgatcatttt cacagccggt tccggcggca gcacaggcta tgataaaacg ctgctggtgg 1050061 atcttgatgg agcggcaaaa gccattgaag ctgcggccat tgccggaatc aaacggttta 1050121 ttatggtcag cgccctgcaa gcccataacc gtgaaaattg gaatgaggca ctcaagcctt 1050181 attatgtggc caagcattat gctgataaaa ttctggaagc gagcggttta acctatacga 1050241 ttatccgtcc gggaggcctt cgcaatgagc ctggaacggg aactgtttca gcagcgaagg 1050301 atctggagcg gggatttatt tcccgtgatg acgttgcaaa aacggtcatt gcctctttag 1050361 atgagaagaa tacggaaaat cgggcctttg atctgacaga aggagatacg ccgattgccg 1050421 aagcattgaa gaaactatga cagtactgac actcagggct ttttgctctt gagtgttttt 1050481 ttctgtttct ctataatgga gaagaaagct tggcttcaat aatgaatgac tattcattca 1050541 cttaaggggt gggagaatga atcttgtttc aaaattggaa gaaacagcat ctgagaagcc 1050601 cgacagcatc gcatgcaggt ttaaagatca catgatgacg tatcaagagc tgaatgaata 1050661 tattcagcga tttgcggacg gccttcagga agccggtatg gagaaagggg accatttagc 1050721 tttgctgctt ggcaattcgc ctgattttat catcgcgttt tttggcgctt taaaagctgg 1050781 gatcgtagtt gttcccatca atccgttgta cacgccgaca gaaattggtt atatgctgac 1050841 aaatggcgat gtaaaggcaa tcgtgggcgt tagccagctt ttgccgcttt atgagagcat 1050901 gcatgaatcg ctgccaaagg ttgagctcgt cattttatgc cagacggggg aggccgagcc 1050961 ggaagctgcg gacccagagg tcaggatgaa aatgacaacg tttgcaaaaa tattgcggcc 1051021 gacatctgcc gctaaacaaa accaagaacc tgtacctgat gataccgcgg ttattttata 1051081 tacgtcagga acgactggaa aaccgaaagg cgcgatgctg acacatcaga atttgtacag 1051141 caatgccaac gatgtcgcag gctatttggg aatggatgag agggacaatg tggtctgcgc 1051201 tcttcccatg tttcacgtgt tttgtttaac cgtctgtatg aatgcaccgc tgatgagcgg 1051261 cgcaactgta ttgattgagc ctcaattcag tccggcatct gtttttaagc ttgttaagca 1051321 gcagcaggcg accatttttg ccggtgtgcc tacaatgtat aactacttgt ttcagcatga 1051381 aaacggaaag aaagatgatt tttcttcgat ccggctgtgc atttcgggag gcgcgtccat 1051441 gccagtcgcg ttgctgacgg cgtttgaaga aaaattcggt gttaccattt tggaaggcta 1051501 cgggctctcg gaagcatcac ccgtcacgtg ctttaacccg tttgacaggg gcagaaagcc 1051561 gggctccatc gggacaagta tcttacatgt cgaaaacaag gtcgtagatc cgctcggacg 1051621 cgagctgccc gctcaccagg tcggcgaatt gatcgtgaaa ggccccaatg tgatgaaggg 1051681 ctattataaa atgccgatgg aaacagagca tgcattaaaa gacgggtggc tttatacggg 1051741 ggacttggca agacgggatg aggacggcta tttttacatt gttgaccgga aaaaagacat 1051801 gatcattgta ggaggataca atgtgtatcc gcgggaggtg gaggaggtgc tgtacagcca 1051861 tccggacgtc aaggaggcgg ttgtcatcgg cgtgccggac ccccaaagcg gggaagcggt 1051921 aaagggatat gtggtgccga aacgctctgg ggtaacagag gaggacatca tgcagcactg 1051981 cgaaaagcat ctggcaaaat acaagcggcc tgccgccatt acgtttcttg acgatattcc 1052041 gaaaaatgcg acggggaaaa tgctcagacg ggcactgaga gatattttgc cccaataaaa 1052101 tgaaaaagcg aagcggttag cttcgctttt tcattttcaa tcctttgctt cttttttaat 1052161 aatatttagc agcgcctttg tatcattttt gcttaatttg tagtatgtgc catccttcaa 1052221 aaaaacggct tgctggctgc cgtcaatcca tagtctgaat gagtcatacc ggtctttatg 1052281 aaacttgatt gtcccttcgt aatcaggggc tgatgttttt tctgtcttca cctgttttcc 1052341 ctgattcata atatccagca tatctttgac gtgctgtctt ttttcaatct cgatatcttc 1052401 ctggccgctt gaagacagtg tgatcaaatc cgcgtctacc gattgataca catcgcctga 1052461 tcggctgtaa agataaaaaa atgcgataaa cacaagaccg attaccacga tggctgccac 1052521 tatttttttc atttgcatca ctccaaacat tgttagtttt cccagcgatc ggggtttcca 1052581 tgcttaaaag ggtggaaaag tgcggaacac agcttggttc taagaatttg aatttatgat 1052641 tacaatagaa gtaacgggtt gatgtgagga gtgaggcgtt atgcgcaagt ggattgcggc 1052701 agcaggactt gcttacgtgc tgtacgggct gtttttttat tggtattttt tcctgtcggg 1052761 tgattccgca ataccggaag ccgtgaaagg gacgcaggct gatccggctt ctttcatgaa 1052821 gccgtctgag ttggcagtgg ccgagcagta ttcgaatgtc aagaattttt tattttttat 1052881 cggggtacca cttgattggt ttctgttttt tgttctgctt gtcagcggtg tttcaaagaa 1052941 aatcaagaaa tggatcgaag cggccgtgcc ttttcggttt ttgcagaccg ttggttttgt 1053001 gtttgtgctt tcgctgatta caacattggt gacgctgcct ttagattgga taggctatca 1053061 agtatcgctt gactataaca tttccacaca gacaacggcc agctgggcta aggatcaggt 1053121 tatcagcttt tggatcagct ttccaatctt tacgctttgc gttctcgttt tttattggct 1053181 gatcaaaagg catgaaaaaa aatggtggtt atacgcctgg ctgttaacag tgccgttttc 1053241 gctgtttctg ttttttattc agccggtcat tatcgatcct ttatacaatg atttttatcc 1053301 gctgaaaaac aaagagcttg aaagcaaaat tttagagctg gcagatgaag ccaatattcc 1053361 ggctgaccat gtatatgaag tgaacatgtc agaaaaaaca aatgcgctga atgcctatgt 1053421 tacaggaatt ggggccaata aacggattgt attgtgggat acgacgctga acaaacttga 1053481 cgattcagaa attctgttta ttatgggcca cgaaatgggc cattatgtca tgaagcacgt 1053541 ttacatcggt ctggctggct atttgctcgt gtcgctcgcc ggattttatg tcattgataa 1053601 gctttacaag cggacggttc gcctaacccg cagcatgttt catttagaag ggcggcatga 1053661 tcttgcggca cttccgctgt tattgctttt gttttctgtt ttgagctttg cggttacgcc 1053721 tttttctaat gctgtctcgc gttatcagga gaataaggct gaccagtatg ggatcgagtt 1053781 gacagagaac agagaagccg ctgttaaaac gtttcaggat ttggccgtga cggggctgag 1053841 ccaggttgat cctccggtgc ttgtgaagat tttcagaggc agccatccgt cgatcatgga 1053901 acggattcaa catgcggaga aagaagagaa tgcgccggaa catcaggatg ctgacaaata 1053961 aaaagaagca ggtatggagg aacctgcttc tttttactat tattgtgcag ctgcttgtac 1054021 gttgattaac ccttttccat agtagaaaga gtttccaaga tatgttgcag tgctttctaa 1054081 acgatcacgg acttgcgcgt ttgtccaagt cgggtgctta gaaagaatta acgctgctgc 1054141 tccggcaacg tgaggagtcg ccatggacgt tccgttataa gcgccgtaag tgcctccagg 1054201 aagtgtgctt tggatggaca cgccaggagc catcacatca agctcagaac ctgcgctgga 1054261 gaatgaagct ctttggttgc tgctgtttac cgcacctact gcaatagtag aaggatattt 1054321 tgcagggtag ccgactgtgc ttgtgcttcc ggatgaacct tcgtttccgg ctgcggcagc 1054381 aacgacgata ccgctggaaa cggctttgtc aacgactgtt ttcagcgctg tagaaccagt 1054441 aggtccgcca aggctcatgt tgataacatc catattgttg gaaatggccc actcaatgcc 1054501 gttaataatc cagctatatt ggccgcttcc tgttgaatca agcactttta ctgcatataa 1054561 tgatgcgctt ggcgctacgc ccagaacacc gattgagtta ttaagagcgg caatcgtacc 1054621 ggctacatgc gtaccgtgag aactgccgtc ctggtatggg tttgtttcag aaggtacgaa 1054681 gcttgctccg cctctgacgt ttaagtcagg atgagaagag tcaattccgc tgtcgataac 1054741 agctactttt acgttagagc ctgtgtagcc ttgagagtga agagccggcg ctttaatttg 1054801 agaaatgcca taaggaacag attgcgcata ttcatgtgca atatgatctt cttccacata 1054861 tgcaacgctc ggatcttttt tcaattcttt tacagctttt tcatccaatg ttgctgcggc 1054921 cgcgttaaca tacttaaatt gcttttgaac ctttccgcct ttttcagaaa taacatcctt 1054981 tttcttggcg gaactcatgg cactcattgt ctgtttaaat ccgacaatgt atttcttttc 1055041 tgtactgctt tttccggcag cctgcgcaga catgttgctg aacgccatcg taaagattaa 1055101 cgttaacgca aacaacaagc tgatccacaa ttttttgctt ctcactcttt accctctcct 1055161 tttaaaaaaa ttcagagtag acttacttaa aagactattc tgtgaattta ttgtaataga 1055221 tggaataata ttttagtaga cccatttttt tgagatgatt ttatctctat ttaggtatat 1055281 catctctcgc tatttccgta gagactcgaa ataactattt tcatacagaa aagaacgaaa 1055341 atagacatga gtaaatgttc attatgctga aatgtcatgc ttttttaggt taaatgctcc 1055401 tgagtcccgg caaattcctg tcgaaaaaat tcgttcaaat gacctgcgtg tgcttccgtg 1055461 agaacaatgg atattatcgt gatatttttt caaagcatga tgataaaagt attctgaaaa 1055521 ataaacttta cagaaaaggg atagaatgaa aaaattattg agagggagga agaaataaga 1055581 tgaacattcg ccaagcaaag acatcagatg cggccgccat tgcgccgctg tttaaccaat 1055641 atcgggaatt ttatagacag gcatccgatt tgcaaggggc agaggctttt ttgaaagctc 1055701 gtttggaaaa tcacgagtct gttattttga tagcagaaga aaatggagaa ttcataggct 1055761 ttacccagct ctatccaacg ttttcttctg tgtcaatgaa aaggatatac atattaaatg 1055821 acttatttgt cgttcctcat gcgcgtacaa agggagccgg cggccggctg ctttctgccg 1055881 caaaggatta tgcagggcaa aacggggcaa aatgtttaac acttcagact gagcaccaca 1055941 accggaaggc aagaagcttg tatgagcaaa acggctatga agaggatacc ggatttgtcc 1056001 attattgtct caatgtgccg gcgaagtgaa aatggcggct tgatgatttg gttttttgaa 1056061 cgttcttcgg ttacgatata aatgaaaagg agtgtgccga atgtcaacgt tatttcaagc 1056121 cttgcaggca gaaaaaaatg ccgatgatgt ttcagtccat gtgaaaacca tatcaacaga 1056181 ggatttgccg aaggatggtg tcctgattaa agttgcttat tccggcatta attacaaaga 1056241 tggtctggcc ggaaaagcag gaggcaatat cgtcagagag tatccgctta ttttaggcat 1056301 tgatgctgcg ggtacggtcg tctcttccaa tgatccgcgt tttgcggagg gggatgaggt 1056361 gatcgcgaca agctatgagc tcggtgtctc acgtgatggc ggattaagtg aatacgcttc 1056421 ggtgcctggt gactggctgg tgcctttgcc acagaatctt tcgttaaaag aagcgatggt 1056481 gtacggaacg gcgggattta ctgcggcgtt atcagtgcat cggcttgaac agaacggtct 1056541 gtctccggaa aaaggcagcg tgctagtcac aggagcaacc ggcggtgtcg gcggaattgc 1056601 ggtatcgatg ctgaacaagc ggggttatga tgtggtggca agtaccggaa accgggaggc 1056661 ggctgattat ttgaaacagc ttggtgcaag cgaagtaatc agcagggaag atgtctatga 1056721 cggaacgctt aaggcgctgt ccaagcagca atggcaggga gcggttgatc cagtcggcgg 1056781 aaaacagctt gcctcgcttt taagcaaaat tcaatacggc ggatctgtcg cagtgagcgg 1056841 cttaaccggc ggaggagaag ttccggcaac cgtgtatcct tttattcttc gcggagtaag 1056901 cctgctcgga atcgattcag tatattgtcc gatggacgtc agagccgctg tttgggagcg 1056961 catgtcttct gatctcaagc ctgatcagct gctgaccatc gtggacaggg aagtatcatt 1057021 ggaagaaacg ccgggtgcgt taaaagatat tttgcaaaat cgcattcaag gaagagtgat 1057081 tgtgaagctt taacaggatc agcttgcaga gaatgttatt tttctgcaag cttttttgtg 1057141 gacaggatga tcagctgctg aactgctgtg tcgcgaaaca agattttcct gtaagccgaa 1057201 ctttctcttc tcattttaaa aataattggt gataatgatt ctcattccgt gttatactac 1057261 tcttggacat cttaaccata gaaactacca acaggagaga ctggaacata tgaaaaaaac 1057321 actgattatt cttacagttt tacttctttc tgtcttaacg gctgcttgct cgtcttcaag 1057381 cggcaatcaa aacagtaaag aacataaagt ggcggtaaca catgatttag ggaagacaaa 1057441 tgtgcctgag catccgaagc gggttgttgt tcttgagcta ggttttattg atacactgct 1057501 tgatctcggc attacgcctg tcggggttgc cgatgacaac aaagcgaagc agctgatcaa 1057561 caaggatgtg ctgaagaaaa ttgacggcta cacatctgtc ggcactcgct cacagccaag 1057621 catggaaaaa atcgcttcat taaaacccga tttaattatt gctgacacga cccggcataa 1057681 gaaggtgtac gatcagctga aaaaaatagc gccgacgatt gcacttaata atttaaatgc 1057741 tgattatcag gatacaattg acgcttcgct tacgattgca aaagcagtcg gcaaggagaa 1057801 ggaaatggag aaaaagctga cggcgcatga agaaaagctt agcgagacaa agcagaaaat 1057861 cagcgcgaac agccagtccg tgcttttgat cggaaataca aatgatacca ttatggccag 1057921 ggatgaaaac ttctttacat cgagactttt aacacaggtc ggctaccgat atgcaatcag 1057981 tacgtcaggc aatagcgatt caagcaatgg cggcgactct gtgaatatga aaatgacact 1058041 ggagcagctg ctgaaaacag atccggatgt gatcatcctg atgacaggaa aaacagatga 1058101 cctcgacgcc gacggtaaac gcccgatcga aaagaatgtc ctttggaaaa aactgaaggc 1058161 agtgaaaaac gggcatgtat accacgtgga tcgtgcggtg tggtctctgc gccgcagtgt 1058221 agacggggcg aatgccattt tggacgagct tcaaaaagag atgccggctg ctaagaaata 1058281 aaagaaaaga caggcaaacg cctgtctttt tcttatttga taaagccgga taagtggctg 1058341 ttgatattat agtcttttat ccgccatttt tcttctgcaa attcaatgtt gctgaggcag 1058401 gcgttgacga gacgggtgct ttgaagctcc gggtcaccgc cggatatttc tgtcagcagg 1058461 gcgtgaattg ccgcaccgtg cgccacgatc agcaccttct tgtttggata cgcctgattc 1058521 acttttgcca aaccgcccat cagcctgtca gtgagttctt ctaaggtttc catattcgga 1058581 tagatgttat ctggatagcg ctttgtccgt tcctccagcg gcatgccctc cgcgtcgccg 1058641 taatcgcgtt ccttaaaatc atccatctcg actatcggaa gatgcagata ttcattaata 1058701 atttccgcgg ttcttttcgc tcttttcagc gggctcgtca caataatatc ccaagaaaag 1058761 tcctttacat attctccggt ttctcttgct tggcgttcac ctgttgcgtt tagcgggata 1058821 tcggttttgc cttggcattt ttgctgcagg ttccaatcgg tttctccatg tcttactaaa 1058881 caaacggctg tcataaaatc cccttcctga ctttattcat atcgctatta tactaaatcg 1058941 aaagcgtgtg tcctatgaaa aagcctatgc aagaacttca aataataaag ccagtccgat 1059001 tccgccgccg cttccgatgg ctgcaacagc atattgacag tctggccgtc ttttcgcttc 1059061 ataaaacaat ctggttacca gagctgcacc tgatgcaccg tacggatggc caagagctaa 1059121 ggcgccgccg cgcacattga tttttgaaaa gggaatgccg agttcttgcg agcagacaca 1059181 aattttgacg gcaaaggctt cattgatttc aaataaatcg atatcatcag gtgttacatc 1059241 gtgtgtatgt aagagctgac gaatcgcgac aaccggtgcc gcgggcggaa agttggggtg 1059301 aatgccgctg acagcgctgc cgataaaccg aagcacaggc ttaagtccca gggctgctgc 1059361 tttttcttct tccattacca aaagagcggc tgctccgtct gctatgccac tgctgttggc 1059421 tgctgtgact gttccggagc tggtgtcgaa aaccggcttt gcacggggaa taatcgcttc 1059481 tattggccgc gttttcaaaa atgcttcgtc cgtctccaat tccccgagag caacaacttc 1059541 ttcacggtaa aatccttcat catgcgcgtt cctgctgcgt tgatggctga gaagcgcgta 1059601 ctcatcctgc atgcttctgc tgatggaata gcgtgcagcc gtatattctg ccgcaatgcc 1059661 catgtctgga tcgccgatcg catctggaga aaagcgagcc cgttctgaaa aaggggattg 1059721 gctgctgctt tctgagccgc ccgcgatata catcgtgccg gctcccgctt gaataaggct 1059781 gcaggcatag cgcacagctt caaggccgga gccgcactgt ctgtcaattg tcattccggg 1059841 aaccgataaa ggcagtccgg cttgaagggc tgacagtctg gccaggttgc cgcctctgcc 1059901 agtagcgttt ccgagaatga cctcgtcaac ttgatcctct agctttcggc tgagacagcg 1059961 gatgatggga gccgccaaat cctccggcag gaagggcttc agcagtccgt tttgatttcc 1060021 aaagatcgtt cgttttgcat caacaataac cgcattcatt tatactgtac actctcttcc 1060081 agccattttt tcactctgga acgggcaatt tttccgctgc tcgtttccgg caagctgtct 1060141 gcaaacaccc attttttcgg aattttatag gaggctaatt tctgtttaca ccaggctttc 1060201 agtgttctgg cattagcgtt tccaagaatg acagctacag cgatttctcc ccaatactcg 1060261 tcgggaatgc caacgacagc cgcgctttca acctctgggc aggcgagaag cacacgttca 1060321 atttcttctg ggaaaatatt taatcctccg tacacgatca tcccgttttc tcttcctgat 1060381 atgtatagaa agccctcttc atcaacgtag cccatatcat ctactgtcat ccattcatct 1060441 ggtgtgctgc cgttcacata gccggaaaac ctcatcgggc ttttgacaaa tatttttccg 1060501 atttctcctg gctggcagcg ttctcctcca gcgttgcgga tttcgatccg gacattatga 1060561 aaagggcggc ccgctgaatg cggcttccgt ttgctgtctt ccggtgaaga aaacgtcaca 1060621 aaactaagct ctgatgtgcc gtaaaaatcg tacagcttga gatgaggcca tgcagcggca 1060681 agcttcttct tggattctgc cggccagtct gcgccggatg aaatgatttt gacgggactg 1060741 tcgggaaaac cctcaatcct tgcgagggcg tctgtcatcg tcggtacggt atagagaaca 1060801 ctgatggatt cacggcacag ccattccttc gctttggcag gagaaaactt tttcagcaaa 1060861 caaacggttc ctccgagaaa caaagtgctg acagccccat ataggaagtg agaggacatt 1060921 aacgctccgg gaatcagaac cttatcatct gatgaaatcg aaaaatctgt ttctgtacag 1060981 gtaaagctct ccatccatga gcggtgagat cgcgtaaagg ccttcggttt tcctgtcgag 1061041 cccgacgtaa atcccatata aaaagggtgc tccggatcaa tggtaggcaa gggatcagcg 1061101 gctgcctcag aaatatctgc catacagtta tccagcaata caacaggtgt ctggctatct 1061161 gtcagtttgt ttttgaaaaa ggctaaagta accacaagat ccgcattgct tatggacagc 1061221 cgctccttac attcagccgg gctccagcgt gtgtcgatgg gaatggccgt acatccagcc 1061281 gctgcggctc cggcaaacag ctgtaaaaac gcgagactat ttgggagcag gatcgccaca 1061341 cgattcggca tgctcggctg tgaccgcagc caatttgcgg tttgagagac aagccgatcc 1061401 caatcatggt acgtgatttg ctccgattca gtctggatcg ctacacggcc gggcgatgtt 1061461 tcggcagtag atgaataggt atgagtaatt gtcatgtatt gtcatcctcc ttttgtaaac 1061521 atcgtatcag aaagagacaa ggcttgagtg atttttatcg ccagaaatgc agatacagcc 1061581 gcttttatca aatcaccagg cacatatgca aggctcatga aggcggcctg tgacaaatca 1061641 atatgcatga taaaagcttg taccggtata ccaagcagat aaataaagat gatgccgaat 1061701 acgatatgag tgaaaaagag acgcaatact gtcaccttcc gcagcctgtt agcggctaaa 1061761 ctgatcagcc atgaagcgag gggataagca atcaaaaagc ctgcgctcgg tccgaaaaac 1061821 acaccaaaac cgcctcgtcc gccgggcaac agcggcgctc cgaaggcgac gagcagcaaa 1061881 aagacaagct ggcttaagaa agcagacttt ggcctgagaa tgctgcctgc caacatgaca 1061941 ccaagcgttt gcaatgtaat cggaacgggt gtaaaggata agaagagagg gggcataaag 1062001 ccgagcactg ccatcagcgc ggtgaaaatc gcaatatgca tcatgtcgat taatttcagc 1062061 atgtgaaatc ctccaaaaag taatcaaata tggttataca ataaatgcag gtaattatta 1062121 tgtcaactga tttttaattt aagtttacat aatgaacgca aaaaaaccgg ccgtatggca 1062181 gaccggtttt tgatggttat tcttctgtca ggatgacaag cgaatcaacg gaagcggcca 1062241 catgggaaac ggcgcggctg acttcctgaa gccctccaag aaaggcttgc agatcgacgt 1062301 cgattttgcc tgattgctct ttgctgattt tcatgctgtg gacgatttca tcgaataagc 1062361 ggttaatttg cgtcattttt tctttacttt cgctgactag ctcattcacg tctttgatat 1062421 gcttggatac aatgttgatt tgtgtattcg tattgttcac aagctcagaa acagtagaga 1062481 cggttttttt cgtatcctca gaaagcttcc gcacttcatt tgccacgaca gcaaagcctt 1062541 tgccgtgttc tccggcgcgg gcggattcaa tagatgcatt gagcgagaga aggtttgttt 1062601 gttcagctat gcctgtgacg atgccgaaga ttttttcaat ttgctgcgcg atttcatcca 1062661 gcttgaccat ttctttttcg atttggacaa ggcttgtgtc aattttgttc atctgttttt 1062721 gctggacttc tagctctttt tttccgccga tcgacttttc ttcaacagtg ctggatgtta 1062781 cagtgccggc tttggatgct tgagaaatgc cttcagattt gtccacaagc tcttgaactg 1062841 atctgcttgt ttctgaaaac agattggcaa tcgatccaga ggtttcttga attttctgat 1062901 gaagaaggtt tttcttttct tcttgttcat cacgggtctg gttgtactcg ctttgaaacg 1062961 cttcaaggac aagctgctgt tctaagttca agatttttgt tgttgcttta atggctttta 1063021 gcagttcttg ctgatttgta atggacgctt cataaatgtc aatcattgac aaaaggagct 1063081 cttgaaacgc acccatatac cattttggca aaaggccgat tcttaaatgg atggaggcga 1063141 ttcggttacg cttttcaata aattcatcat cgataacgcc tgcaaacatt tcctgaatat 1063201 gccgttttaa cgtttgtttt aagcggtcaa ctgagctgtg atcattaatg atatccatca 1063261 atgagctttc atggtcaagg tttttataaa acgcatcgac gatatttacg atattttctt 1063321 gaatgagtgg ctgaagctgc tctaacacat aaagctcagc atctcccaac ctgaccattt 1063381 tgagctgttt tttgacatct gcatgtttgt ttgtgagctg aatgcggttt ttttgttgtc 1063441 cgtttgaatc tgaaaagtaa gctgtttctt gttttctgtc ttttttaaat aacaatacaa 1063501 tgatccccct tgggaaaaat ataattttta ctttttggct ttttaagcct ttttcttttt 1063561 tatcggccaa gggaaacatg aatgaagctg cagatgaaaa atatttgaaa aaacgttcat 1063621 taaaatgaac ggtttaatcg agatctattt gttttaatgg tttaatggcc ggaccctcta 1063681 caacttcgcc agatggctta aagcgtgatc cgtggcacgg acaatcccac gtatgctcac 1063741 tgtcgttcca ctcgacctcg cagcctaaat gggtacaagt cgtatcaacg agatggaggc 1063801 agcctgtctc atcacgaaat gctcccgctc gcctgccgtt tatggtgacg gctttccctt 1063861 ctcctggcga aatgtcttca aattggacat caggcttttc aagctttcct tttatcaaat 1063921 gcttggcgac atctgcattg taggaaatca ctttctgcaa cccgggattc agatggaaac 1063981 gggacggcgt gaaaatgctt tcgtatgggt tttctttttt ctccacaagg tctgacaata 1064041 aagtggctgc gactgctgag gacgtcatgc cccatttttt gaacccggtc gctactagaa 1064101 tattgtcctc attttccgac atcggcccga taaacgggat tttgtcgatc gtcactagat 1064161 cttgggtgga ccaataatat ggaatgcttt cgatgccgat ggtgctttcg gccagttgtc 1064221 tcagtgtttc ataatgtgta gacatggctt ttccctggcc tgttttatgg cttactccgc 1064281 tgaagagaat cagcttttca ccgtttacaa ccgtatagcg gagcgccact gacggctgat 1064341 cgatactcaa atacatgccc tcgggatact cgatcttcgg cttgatggca aggacataag 1064401 atctgtcgga gtacattctc gcagcatata atccgcctcc gtcataaaaa gggaagtggg 1064461 aacagcatat gataaagcgg ctcttaatgg cgtgccggct ttttgttacc acttcgggcc 1064521 tttcgccttt tttgatatca agcgcaacgg tctcttcata aattcggccg cctttttgaa 1064581 caatttgctc cagaagcgct tttaagtatt gaagcggatg aaattgagct tgattcttca 1064641 tgacaagcgc cagcttagaa cctaagggaa ttggaagatc cttgataagg tctctttcaa 1064701 ttccgagctt tgtgtatgcc tcatgctcgg tgtggatttt ttgaacagcg ttttcatttg 1064761 ccgtataaag atatgcgtct tgctcgatcc attcacaatc aatttgatgt tcatccacaa 1064821 tgccttttat gtaatcaatt gcgttttggt ttgcttcata ataaagcctc gcatggttta 1064881 atccgaaatg gcggataaat tcgtcgtata tcatgtcatg ctgtgcggta actttagcag 1064941 ttgtatgcgc agtggttccg ttaagaacct gatttgcttc aatcaaaacg acacggaagc 1065001 ctctcttcgt aagttcatat gccgttgtga ttcccgtaat cccgcctccg ataatggtga 1065061 cgtcacattc agtgtcctct tgaagcgcag gaaaagaagg caggtcagtt gatgttttcc 1065121 agtatgtttc aggtgcttcc tttgcaaaat gttgattagc caagccgtta tacctccaat 1065181 cagatttatt cttaattttt ccatattcta tcttttcata cataggaagc aggcattgtt 1065241 cataacataa taaggttgaa aaggagtgat ttcattggcg aatcaaaaaa agaaaacatt 1065301 accgcctcag caccagaacc agcagcctgg ttttgaatat ctgatggacc cgcgtccggt 1065361 ttttgataag ccgaagaaag cgaaaaaatt agagggcaaa accgctatta ttactggagg 1065421 agacagcggg attggacgcg ctgtctcggt gttattcgca aaagaagggg ctaatgtggt 1065481 cattgtgtat ttgaatgaac atcaggacgc cgaggaaaca aagcagtatg tagaaaagga 1065541 aggggtaaaa tgcctgctga ttgcaggaga tgtcggggat gaagcgtttt gcaatgatgt 1065601 ggtcgggcag gcaagccaag tgtttccatc cattgatata ttggttaaca atgcagctga 1065661 gcagcatgtc cagcccagca ttgaaaaaat caccagccac cagctgatca gaaccttcca 1065721 aacaaacatt ttttccatgt tttacttaac aaaggcagtg ctgcctcatt taaaaaaagg 1065781 gagctctatt attaataccg cttcaattac cgcctataaa ggcaataaaa cgctgatcga 1065841 ttattcagcg acaaaaggcg cgatcgttac gtttacaagg tccctttccc agtcgcttgt 1065901 tcagcagggc atacgggtca atgcagtggc accgggtccc atttggacac cgcttatccc 1065961 ggccagcttt gccgcaaaag acgtggaagt gtttggttca gacgtgccga tggaacgccc 1066021 ggggcagccg gtcgaagtgg cgccaagcta tctatacctt gccagcgacg attccacata 1066081 cgtcacaggg cagacgattc acgtcaatgg cggaacaatt gtgaacggat aataaaaagc 1066141 caatccttga aggattggct tattcgctct gcttgagcgc tgcatattct ttagagagcg 1066201 taagaaacgc atctttatct ttttcgtcca aggctttgtt aatttggtcc gtcagcatgg 1066261 caagccgacg gttatacaag gattcatcga gcaccatttg aatgtaaata tccgtcattg 1066321 tgacatcgaa ttcttttgtt ttttgcgtgt tgcgggactt catgagctca gtgtacgatt 1066381 ttttctcttt cataaagaat ccccccaatg ccttttttat agtatatgga taacggtcga 1066441 aaaaatcaat aaatttttat aatttttaga caactaatac ttggcaatct atcgacatat 1066501 cctgcaaaat gccgtaaacc ggcaagtctt atgaaagtaa aatcggttta ttactagtca 1066561 tttagtacca ttaaatatca ttaaaagatg attttatctt aaatgttaaa aaaacctgtc 1066621 gttttacaaa aacagatgat agattattag tataaatttt gcagaaaaag gatggaggcc 1066681 ataatatgag tcagaaaaca gacgcacctt tagaatcgta tgaagtgaac ggcgcaacaa 1066741 ttgccgtgct gccagaagaa atagacggca aaatctgttc caaaattatt gaaaaagatt 1066801 gcgtgtttta tgtaaacatg aagccgctgc aaattgtcga cagaagctgc cgattttttg 1066861 gatcaagcta tgcgggaaga aaagcaggaa cttatgaagt gacaaaaatt tcacacaagc 1066921 cgccgatcat ggtggaccct tcgaaccaaa tctttttatt ccctacactt tcttcgacaa 1066981 gaccccaatg cggctggatt tcccatgtgc atgtaaaaga attcaaagcg actgaattcg 1067041 acgatacgga agtgacgttt tccaatggga aaacgatgga gctgccgatc tcttataatt 1067101 cgttcgagaa ccaggtatac cgaacagcgt ggctcagaac caaattccaa gacagaatcg 1067161 accaccgcgt gccgaaaaga caggaattta tgctgtaccc gaaagaagag cggacgaaga 1067221 tgatttatga ttttattttg cgtgagctcg gggaacggta ttagaaaaat aggaaggagc 1067281 tgaccgaaca gggcagctcc tttcataaag ctatgccgtc ggaattcctc cggtgatgcc 1067341 atatacctga gatgtcacat agcttgaatt ctctgaagct agaaatacat aaacatcggc 1067401 caattccact ggctgcccag cgcgatttaa tggagctggc ggcgtgcctt gtccgaattt 1067461 cgggatgttt tccgtcggct gtccgccgga aatttgcagc ggtgtccaaa ttggtccggg 1067521 cgcaactgaa tttactctga tgcctttgga agcaagctgt tttcccagtc cgacggtaaa 1067581 gccgataatg gcgtttttcg ttgctgcgta atctaacagc atcgggcttg gattatagcc 1067641 ttcaactgag gtagttgtga taattgaagc tccctccggc aaatacggaa gcgccgcttt 1067701 tacaacccag taaagggaaa agacgttcac ttcaaatgtt ttatagattt gttcagtagg 1067761 cagatcttcg atgttttcga ccgcttgctg tttgcctgca acgagcgcta gcacatcaag 1067821 tccgccgagt tcgtgatgcg actgtttgac tagatcttgg caaaaggatt cgtcgctcaa 1067881 gtctccgggg atcagcactg cttttcggcc ttctgcttca atcagctctt ttacctcttc 1067941 agcatctggc tgttcctcgg gcaagtagtt aatagccaca tcggcacctt ctctggcgta 1068001 agcaattgcg gcagcgcggc cgataccgga atcgccgccc gtgacaagcg cttttcgacc 1068061 cgttagttta cctgatcctt tgtagctttt ttctccgcaa tcagggacag gcttcatgtt 1068121 cttttgcagg cctggcggtt cttgatattg ttcgggaaat tcatcatgaa aaaatgcttt 1068181 tataggattc gtaagatttg aatcagacat cagcaacgct ccttttctgt ttggtgtaca 1068241 ttcgtatgtg tacccctgag cataagcaga aaaacatgtt ttggcagttt gaatagtgaa 1068301 ggaaaaagaa aacaagaaaa aacaaagcct tcttccatat ttatcttgtc aaataagact 1068361 atatgaatta tgataaattc gagctataaa tcaactaaat attgggtgtt gggagagtga 1068421 atcgtcatga aaaaagcggc ggcggttttg ctgtcactcg gtctcgtttt cggtttttca 1068481 tacggagctg gccatgtggc ggaagccaaa acaaaggtga aggtctataa gaactgcaag 1068541 gagctaaaca aagtatacaa aggcggagtg gcccgcacat cgaaggtgaa aaacaaaggc 1068601 ggaaaaacga agtacaagcc ttacgtttct aaggcacttt acgatgccaa taaaaacaaa 1068661 gaccgcgata aagatcttat cgcctgtgaa cggtaaataa gaaaaagcaa tctggtgtcc 1068721 agattgcttt ttttatgctt aggccgcctg atcggccgca gcgcttttcg ccttccttgt 1068781 cataaggctg actgccatca tgaccgtgat attcaaaagc agggcgacga tgccgacatt 1068841 caagtctttt gcggcttgcg gcagagccgg aaataaagtg ccgatcgtcg tttccgtcat 1068901 tgtaatataa gtaactgctc cgacacctgc aataatgccg gcgaaagctc cttgctttgt 1068961 caccatatta tgcttgagca ggctgaacaa aagggcgggg aatagctgtg tgacaaggct 1069021 gtagcccatc aaaagcagcg taacgatggt attcccgcct ttgaaggtaa aatacaccga 1069081 aatcagcgca atcaccggca ctaaaaactt agcaagcgcc gatacttgct gttctgtcgt 1069141 gcggggcgcg attaccttgt acacattttt tgcaaacagt gtggaggcgg acattaagat 1069201 catagaccct ggcacaagtg ctgtcagcag tccggcagca ccgataattc cgacaaacca 1069261 agggtcaaat gcttgcagag acagtctcaa aagcgacaaa tccccgtctg cgccattcag 1069321 atctggaact tgcaggatag ccgcaaagcc gacgaaaagg acgaagagca ggaccagctg 1069381 gtacaaaggc atgatgatgg cgtttttacg aaacactttt gggttttcgg ctgaatacga 1069441 agcggaaaac gtgtgaggcc acatgtaaaa accaagcgct gtcaagagta cggttgaact 1069501 gaaccaggcc acactttgtc ccgattcggg gagcgtaaga aagccaggct ttgccgtttc 1069561 aatctgctga aacatgtctt gaaatccgcc gtagtaatga attggcaaat acacacctaa 1069621 aaacagaacg acaaccagaa tcatgatgtc cttcacaacc gatatccagg cagacccgtg 1069681 aatgcctgaa accataacat aaaccgtgat ggaaacagcg ccgatccaga tggcagcggt 1069741 cggggtgatt ttgccgtacg aggtttccga tacaatcagc ccgaggcctt tcagctgcag 1069801 tacaagatag ggaatgagtg cggcgatgcc gaccagtgaa acgagaatgc caagcagcgg 1069861 actgttgtat ttttttgtga aaaaatcaga ctgcgacatc agtttatgct gtttcgcgta 1069921 cgtccaaact gctggaagaa gccagtaaga aaggatgtag gccagacatc cgtaggcgat 1069981 gatataaaag gctggaccgc cttttccgta ggcccagccg ctgccgccga gaaacgtaaa 1070041 agtagtataa atttcgcctg ccatcaaaag gaagacgaaa acagttccga agccgcgccc 1070101 tccgaccgtc cactgctcca ggttcatgtc ttttcctttt tgggcgcgta taccgagaaa 1070161 aatactcaag agcaggacac cgaagatgat gatgagagct gcattcattc tgcttcctcc 1070221 tttttatttt ccttgtcgag gacatacaca atcgccatca gcgcagaggt caaaagagcc 1070281 cacatcacaa tataggcaag aataaacggc atgccgaaca catagggggt caccttattt 1070341 gcaaaaggga tgccgagtaa gattccgata aagggtaaag cggcaagaac gtgaatcagt 1070401 ttcatagaat cctccttcta tttaggattg aggtgtacaa gcctaagcgt actgaaaatg 1070461 atgtcgcaga tatcgcagca catgtcattt tttggagtga aaggctgtgg ttcgaattat 1070521 aaataaattt attttgtttg tatagtgtga attgtctgaa attaatgctc tgaatcgccc 1070581 gaagagggaa cgggcagtat gattcaaaag gctcagagtc tgtctggggc aaatagatag 1070641 tatgttaata attcgctgac ctgctcacgg attcgcggat taaaatagcg atggttttct 1070701 tcataaccgt cgatgacaaa tgtatagagt gtaaaggcct catcgcgttc cgtctcgcgg 1070761 attgcaattt ttcttttcct cagttctttt ctgacctcca tcaaatcctt ttgtgctatt 1070821 tttaatgatt cgctgataag ctgtttataa ggatgcttca attttaatgt gctttcttca 1070881 attccggcga gatcacggtt aaaaatcgta atggccatgg gcaaaaagag agcccgttca 1070941 attaaatcgt atatttcctc ctgcagattt ggcatattga ctccttcttt ctaagggaac 1071001 gtttgttcta tttgtattct atatcggctg gtgaaatgtt tcaagacaga aaaaatcacc 1071061 aaaacttttt agttttctgc tgataatgtg tagaataagg atagacaaac ccggtaagga 1071121 gtataaatgt tggagcattt tttatcctat ttgacacaag aacatttaac tgaattattt 1071181 caaagctata gggctttcgg tccgctcatt gctgtgctgc tgcctttaat tgaagcattt 1071241 ctcccgtttt tgccgctgat cgtgtttgtg gtggcgaata cgaactcgtt tggcttgtgg 1071301 gaaggattca tcctatcctg ggcgggatca actgctggtt ccattctcgt ctttttgatt 1071361 gtccgtcaat acggacagag aaaattgctt ggatttatcc gcagtcatcc gtctgtcaga 1071421 aagctgatgt tatgggtgga aagacacggc ttcggtccca tgtttcttct gctttgtttt 1071481 ccatttacac cgtcagccgc ggtgaatgtt gttgccggtt tgtcaaggat cggaacgcgg 1071541 ccgtttattt tggcggcagc ctcggggaag cttgtcatga tttttatgat cagcttcatc 1071601 ggatatgatc tgcacgcgct gattacacag ccgattcgaa cggtcatcgc cgtattggtg 1071661 atcactgtct tatggtatgt cggcaaaaag gtggagcggt atctgcatgt aagagccagt 1071721 cagcgtgagc atgatggagg gagacagtaa catgaaaaaa cggttttggt ttcttgccgg 1071781 tgtagtgtcc gttgttctcg ccattcaggt taaaaatgct gtctttattg attacaaggt 1071841 agaaggcgtc agtatgaacc cgaccttcca ggaaggaaac gaattgttgg tcaataaatt 1071901 ttcgcatcga tttaaaacca tccatcgttt tgacatcgtc ctttttaaag gccctgatca 1071961 taaagtgctg attaaacggg taatcggctt gcccggtgaa acgatcaaat ataaagatga 1072021 tcagctgtat gtgaacggaa agcaggttgc tgagccattt ttgaagcatt tgaaatctgt 1072081 ttctgccggc agccatgtaa cgggtgattt ttctttgaaa gatgtgacgg gaacaagcaa 1072141 ggtgccgaaa ggaaaatatt ttgtcgttgg agataatcgc atatacagct tcgacagccg 1072201 gcattttggt ccgataagag aaaaaaatat tgtcggtgtg atttctgatg ccgaataaaa 1072261 agacgctaat tgaagaggcg tctttttgta tgccgtttgg aaaaatgtgt tgaagaaaaa 1072321 tttgtaagga gctataatca aaattgttac ctgtgtaaca aaatttatat atttttttga 1072381 ctggagggcc gtttttattg gtttttgttc gtttttcatg aaacaaaagg agtggtgaat 1072441 gatgatgaaa tatgaagcag tgattatagg aggagggccg gttggattta tgctggcttc 1072501 tgagcttgca atagccggag tgggaacatg tgtgattgaa cggcttgaaa aacctgttcc 1072561 gcattccaag gcgttgacgc tgcacccccg aacgctggag cttcttgaga tgagagggat 1072621 tttagagcgg ttcgtatcca agggaagcaa gatacctacc ggacattttt caatgctgga 1072681 tacccgtctg gatttttcag gcttggatac gagctgtcct tacacgcttt tgctcccgca 1072741 gtccaaaaca gaaaagcttc ttgaagatca tgcacgaagc ctgggaacag aggtgtttcg 1072801 gggtgccgag gcgctggcgg ttacgcaaaa cggggaagcg gtccaaacaa tttttaagga 1072861 tcgggacggc agtgtacgga cgatcacaag caagtttgcc gttggggcag atggcgccgg 1072921 gagtaccgtc cggaaacagg cgaaaattga gtttccggga acagacagca ctgtcaccgc 1072981 tgcgcttggg gatgtggtgc tcctttctcc gccgccgtca ggtgtgctgt ccctttgcac 1073041 aaaagagggc ggtgttatga ttgttccgtt atctccagac cgataccgtg tcgttgtgat 1073101 cagcccttat cgcacacaaa cgccgaaaga tgtgcctgtg actgaggaag agctgaaagc 1073161 tgacctcctg cgaatttgcg gaactgactt cggtttaacc gacccttcgt ggatgtcgcg 1073221 gtttgggaac gccgcgcgcc aagcgaaacg gtatcgggac ggcagaatct ttcttgcggg 1073281 tgatgccgcg catattcatt ttccggcggg cgggcaagga ctgaatgtcg gccttcagga 1073341 tgcaatgaac ctcgggtgga aactggcggc ggccatcaaa ggctctgcgc cttcttggct 1073401 tttggacagc taccatgatg agcggcatcc ggcagcggaa gggctcctca gaaacacgga 1073461 ggcacagaca aagctgatcg atttcactca agcaggcctc catttgcgaa gcatgatgtc 1073521 ggagctgctg gccttccctg atgtgaatcg atatgtagcg gggcaaattt ctgcgctcga 1073581 tgtcagatat gaagctgatc gtaccatgcc gccgaatcgt ttgaacgggg caaggctccc 1073641 tgacatgaag ctgattcttt ccgacggcaa ttcggaacgg ctgtacagct ttctccaaaa 1073701 cgggacattc gttttgctgt cattgaggca ggaagctgat gatcatatcg aagtaaaagg 1073761 cttacgtacg gtaaccgcct cgcttgcaga accgaatgaa aagttgcgga atgtgcatac 1073821 catattgatt cgtcccgatg gacatgtagc ctgggcggtg gatgcatcag cgcccgattg 1073881 ttccgaggtg attcaaaaag ggatcagccg ctggttttcc gtcaccagcc gagtataatt 1073941 caattcgatt gtttcatctg taacaaaacg gtatgataga agaaacaatc gaatgaaaaa 1074001 ggatggaaaa cccgatgaac acagatcata cgaaacgcaa tctttttgaa ttgtatgcgg 1074061 agctcattca tcagcaggag aaatgggagg ggcttattaa agccttttta tctgacgaat 1074121 tgaggaagct ggatgtagag cacgggagta aatctcaatt gacgatgaca gaaattcatg 1074181 ttctatcctg tgtcggggac aatgaaccaa ttaatgtcac gtcgatagca gaaaaaatga 1074241 atacgacaaa agcgactgta tcacgcatca gcacaaaatt gctcggcgca ggcttccttc 1074301 acagaacaca gctcagcgat aataaaaagg aggtctactt ccgattgacg cctgctggaa 1074361 aaaagctgca cagtttgcac aaatattatc atcagaaggc tgaacagcgt tttctgtcat 1074421 tttttgaccg ctataccgag gaagagattc tttttgcgga acggctgttt cgggatctgg 1074481 tgacaaaatg gtatccgtcg tcagaagaaa ttgaaggggg gcttcctagc atttttaaat 1074541 aaaaaacacg cactgcggtg cgtgtttttc gctttgtttc tatctttttc aaggctgtaa 1074601 cgtaaatcag atttcctctt gaagaatgaa attcaagatg ttcaggaatt tgcactgctt 1074661 atacgatatg tctattagta tctttatttt atacgttttc tactgtgttt ttgatgcttt 1074721 gttttcaagt gaaatagggt cttctgtttt agttctccta atctttacag aaatacctac 1074781 tagaatgacc gccatagttg taaatattcc catggttaat aagatcgtat cctggtttaa 1074841 actccatcca attaagaaag agatgatcgc tcctccgaaa cttgccgagg caataaataa 1074901 acttgtaact tcgtcaacgt acttctgaat aatgattgat gctagtgtta aagcaatggg 1074961 aaatatcccc gctatactta ggccaatcaa aaatgtacca ctcaattgaa gtattgggtt 1075021 acttatataa gagaaggcaa tcaacaaaac aattaaacaa ctacagctaa aaagaaggta 1075081 tttggaaaaa tcaagccttc tacttacgaa accaatcaat attcttccta tgatgatccc 1075141 tacccagaaa aaggagacac ttataagact aatttgttca ttgtcttggt ttatcatgat 1075201 tgaaggtaaa aagttggcaa aatttgtttc aattccagca tataggaaag cgaaaaatac 1075261 aaaaaagcct aattgctttg atttttttct atctcctata aagtattgaa atgctcctcc 1075321 atctggaaag gtcacttgtt ggttagcatt cttagcgtac tctcggttct tagacaagaa 1075381 aattaaccac cctacgaata ggacgaataa aaaggtgaat atacagtaat atggtaaaaa 1075441 ccagttattg atatctatga aggaattaat taataatggg aaagataaag cgcctaatcc 1075501 aaagagaact tccagcttac tcattttttc tgcattactt tcgaaattag caataacaaa 1075561 tgaaccaact gtcgtttcta atgtgcctgc tccatatcct aagagaaaag ccattacaat 1075621 aatataatac caatccttgg ttagaaaaaa gatacttaac gctacaagca ttattgtcaa 1075681 agctaaagta agtgtcctaa aatgactgta tttcttaatc attaaaggtg cgattaatac 1075741 tccgcttaga aatccggtaa actggaagaa gattatgacc gaaatatcat ctgttgtctt 1075801 gttaaaagcc tctaataaaa atggtgtcaa actccctgtt gatatatgga taatacctac 1075861 tgtaaaaaag aaagcatatc caaataaata tgtccctctt aacattcatt acacccctat 1075921 atgaaaaagc aggaaagtaa attcctgctt ttttagtaac ttctctcttt gaaatactag 1075981 ttgactgctg aaacagacat gggttgagag ttgctgtctt tctcaaagaa catttctaat 1076041 acttcctgag atctaaaacc atcactaaaa gaagggatct caacccaatc attctgagtt 1076101 gatgcaatcc aattgattaa ctcgcttcta aaagaatcag cccatccata aaactcgttt 1076161 ggcggatcgt ttaataggct ttgcggtact gggcagtcta ccacgttcaa gccatctatg 1076221 agcttgtaaa cgtgaggatt acctgtgtgg tatttaaact cttttttgtg tccaactacc 1076281 tcaatgctaa aaccacagtc ttcaggtaca gaacactttg atgtgatgat atttacaaat 1076341 accttgttct tcagctggcc ataaatttct gcatagtcat ctacaagtac ctgtttatcc 1076401 tcttttgttt ttacatttgt gttcatcttt gcccttactg attctgtgat gaaatcactc 1076461 tcgaacaaat accataccat gtcaataagg tgaataccca gatcccccaa tgatccactc 1076521 gtcttcttac tattagcgtc atctctccaa gtaaacttct tacgtctaag tgcactattt 1076581 ttcttgaagt gtacttttat ggacagtatg ttacctagtt cattattgat aattaagctt 1076641 tttaagatat ttacgtaaga taaatatcta taattaaatc ccatactggc tcttacgctc 1076701 aacctttcag cagtatcttt cattatgctt gcttcttcaa gagaaatagc cataggcttt 1076761 tcacataata catgcttatg ttttcctaat gcttgcaaag catgttcttt atggcaaaag 1076821 tttggtgatg ctacaattaa accttctgag gcatcaatta gttcatctac gttttcaaat 1076881 gacttcccgc cgaaagtttt cacaaagctt tccgcatttt gttgatttat gtcatatacc 1076941 cctactaact ctgcattttt tattgtagat aaagcagttg catgcgctct tgcaatacca 1077001 cctgcaccta tgatgcctat cttcttcatt tttatttcct cctcatgatc caattaattt 1077061 ttttaaggta ttagtaattc cttttgagta ctcactatca gttataaggt tgtgcaagtt 1077121 tttggcttcc tgtgttgcat tttttagcag atatccattc cctactgtct gtaacatacg 1077181 aacatcattt ccactatccc caaatgcgat agctctttcg gtatttaggt tgtatttctc 1077241 taacataaac gttacaattt cattctttcc tgtccctatg gggataaaat ctacatcata 1077301 gctgtcttct ggatcgcctg ctaagggatt acaccgattt atatttactg aaacgccgta 1077361 ttcttcgcag attttttcaa tagctaatag gtttttcttg tcgtttattt catcttgttc 1077421 ctgatagtag aagttatgct tataccgtga ctttcctaat tgggtttgag gattcaaaag 1077481 aatgttatga ttttcatgca gctgtttcac aagtttttca accttttctt tactaaaccc 1077541 ttcatttatg cgactgttcc acttgttatc ttgctgaccg aagttatgct ctgaaaagta 1077601 cgtaatttca gttccaagat cactagctat aaaatgcgga aaatatctaa attttcctcg 1077661 tcccatttta tcgagaatag attctatact gctcccagta acccatccga ttattagctc 1077721 cccatcttta cttttttgtt ctagatagtc ttcgagttca tagatgtctt gttgcttttg 1077781 ttcgtcgatt gtatgcggaa aatacgtttc atcaaaatca caaaaaacaa tatattgagg 1077841 atgttcaacc gtggataacg ttttatactc cgatttcttg cttaataaca tgaaacagtc 1077901 cctccattac tctgtcttgt tcttctaaag taaatgacgg atataaaggc aaatgcagta 1077961 cctgactatg agccttttcc gtatgaacca attggagtcc tgcatacttg tcctgtacta 1078021 aaggagtttt ttgcatatga gaaagtattg gataatatac atctgtttga acaccaaaat 1078081 cttcatttaa tttagtcatg atatctgccc tatcttctgt tcttacctta ataggaaaca 1078141 gatgccatac atgatcttca cttaattctg gtaattcaat atagccttta ttctgcaact 1078201 ctgctaattg ggtaatgtat ctatccgcca agaacaatct tttgaagttg tttaatgaaa 1078261 ggtacttcat tctctctaaa ccaattgctg cctgtaaatt gtccattttt gaattaaatc 1078321 caaaattgat gactttctta ttttttacat ttacttcaaa accgtgataa ctaaattgaa 1078381 tgcatttttt agcgagttct tcattatcag ttgctattgc cccagccttg ccacatacac 1078441 caaaattctt atagggatta aaacttaatg tagtgatgtc tgcatacttt cctaagtctg 1078501 tcagtccaat tccttggcag gcatcttcaa ttacttttaa tttataacga tttgcgattt 1078561 gacggatatg ctgcatgtct gaatgttttc cgtataaatg cacaggtaga ataaactttg 1078621 tataaggagt tattgcttct tcaattttgt caggatcgat gcagaatgtt tgtgggttaa 1078681 tatctacata gataggaacg cctcccgaag ctaacacagc attttcagta gctgaaaagc 1078741 tattagccgg catgataact tcatcccctg ggtttaaccc taaagccaat aaacctatca 1078801 taatagcatc ggttccactg ctggttgcaa ttacatacct tttatgtaaa tatgtagata 1078861 aaactttttc gaattgctct aaatagggac cactcgtaaa ttttccagtt ggcaaaactt 1078921 cagttaatgt atttaagata tcttccactt catcattggt tattaatctg tctacaggca 1078981 aaaaagggac tttactgatt tcacgatttt tttgatagtt gaaaaggtca tgttcaatat 1079041 ctatcttttc ttttaatact tgtttccacc gctcgtttac aatactgtct tcaataacaa 1079101 gttcttttcc ttgtacgtca ccttttaagt gttttaatag tgacatgttt tctttgcttt 1079161 tacctgaaat cttaacctgt ttttgcatga acagtacctc caatgatttt ataatctaaa 1079221 aatttattac aaatttatcc tagtttctga aatcggtaac atgtcaacaa cttttttaag 1079281 gaagggaaaa tatgcctaca attgatgaaa tagcaaaatt atgcaatgtg tctaaaacca 1079341 cagtgtcaag agtattgaat aatcatcctt atgtgtcgaa agaaaaaaga gatatgatct 1079401 taaaggctat taacgaactt gactacactc ccaattattt agctcggaat tttaggagaa 1079461 ataagacaca aacgatagct ttatcggttc cgagtatcga ccatccattt tttgctcaat 1079521 taataaaagg ggtctctcat gaagtactgt ttaagaatta caaggtaatt gtatttcaga 1079581 ccttttatga caaacagacg gagctagaat tactagagtt attgaagcat aaagaagtgg 1079641 atggcattat tcttgggact ttagaaaatg aatgggatca gatatcccct ttcttaaagt 1079701 atggtcctat cttattatgt aatgaatatc atcactcagc ggacatcacg ataattgggt 1079761 atgatgaatt tgaagccgca tacatggggg tagtacattt aattgaaaga gggcataaaa 1079821 aaattgggtt ttgttttgat actccatata gcgaagctca atgtcagagg aaagagggtt 1079881 atttgaaagc tttacaagat tacaatttac atcatagaag cgaatggata ttcggcgaaa 1079941 tgtttaatat cgaggatggc tttcgtgttt ttcataagat aaaggatcta aaggacagac 1080001 cctcagcaat atttacagga aatgatcaag tcgccgcagg gattattaaa caggcgatga 1080061 aaaatggctt taaagttcca gaagacttag ctgtaattgg ttttgacaac caattgattt 1080121 gccaagtcgt tactccgacc ataacaacaa ttgatatccc cgtaatagaa ttaggccaac 1080181 aggctgtgtt gaaaatcatc gagtccattt cgggtaatgc ctctttaaac agaagaatta 1080241 ttaaactgcc aacaaagctt attataagag aatcaacgta acgatagatt tccctttaac 1080301 attttatatc tttatataag aaaaagaggt tattcatttt aacctctttt tcaatcgtaa 1080361 gtcgtcaatt atttctttca tttcaccctc tggcagcact cacttcaaat ctgatccatt 1080421 aacaacgaaa tatccgctta tatttcctca tctcgatggt ttgcgaatta aaagttcttg 1080481 aacccttttt tcaactaggc actactgccg ctgattgagc tctttttgtc ttttttttca 1080541 ccatgaagat ggtgaagcag gcgataaaac ggcggcagca gggcaataac cagaatgacg 1080601 cgaatgacct gaaccgcaac gacaaaggtg gaatcagcat gtaaggtaac tgacgtcgtc 1080661 gccatctctg caatcccgcc gggcgcaaat gccagaacag aagtgatgag cgaaattcct 1080721 gtcagctcgg aaacgatcac ggcgctcaaa aacattgctg cgattaaacc gacggacgag 1080781 acaaacccga cgatgataat acgggtgacg ccggcaaaca tgcttttgta catcttagag 1080841 ccgatcgttg ccccgagaaa tacttgtgat acatggttag cttgtgacaa ccaccatgcc 1080901 gtcatgtcgt gccctgtcac cgcagctccg ccaacatgta caattgctac accgagcatg 1080961 ctgccgagca gccatggagc tggaaatttt aaaaatttcg cagctttgca agctccccag 1081021 gcagcgagaa taagaatgac ggtccacaaa acgggagcga gcctaaaatc tgtcgttgca 1081081 gaagaaatcg tctctgctgc ggcacttgcg gtacgatctt gttttgtata gatcagaatg 1081141 actaaaaacg gaatggaaag caccacgagc agcacacgca tcatttgaac gaggctgact 1081201 atagcggtat tggcgcctac ttcctgtgcg atgctcggca tggcggaaag tccgccggga 1081261 gcggtgccga caaagctagt catcatatcc gttttgctga aacgccaaag cacatatcct 1081321 gacagcatgg ccagcaggat agacaatatc agcataacgc cgactgaaaa ccaatggtct 1081381 ttgagaacag agagaacgga taaattcagc ttttggccca attcgatgcc gaggatcatc 1081441 tgcccgaggg cgagccatcg tcggttaatt cctttttggt ctggtgccat catcagccat 1081501 gccggccgta tcatggcgag gcagcaggcg acaatcagtg ttccgatcat ccatccaatt 1081561 gatattccgg ttaatgaaag aataaacccc ccggctgcac tgattgcgat aaaccataga 1081621 tctttgagga gattttcgtc tttcttcaat gtaaaaccct tcttcctttt tcacgtaaca 1081681 ctccaattgt tcacgtagtg aatgtattta ttactatagt atatttttgt tgataaagaa 1081741 attatgaatt attttctata agcgattcac ttttcttatg accttgtgtt cgagcttttc 1081801 tattgtgtaa gtcagagata aacccgctgt cagcagacac acggcaagag cgtaaaaaat 1081861 cacttctccg ccaaatgatg tcaggatcag cccgcctgcc agcggtccga ttgagcggga 1081921 tatatcccaa tgcagaccat agacagcata aaaccggccc agcaaatgag gcggcgccaa 1081981 tttcgatatg aaggtctgga tgtgggttag cccgatgctt tcaccaaccg tcatcaccgc 1082041 tgccgtcact aaaagcattg tcagagaggt tgagcatgca aagccggctg ccgcaaggga 1082101 gtagcaaata taagtaatga agaggatcgt tttcattgaa agcttttcgg tccctttgac 1082161 aagaggtact tggagaacac agctgaataa agcttttgct gctgaataga tggtcagcat 1082221 ggacagataa tcagaaaaca tgtttttgct gaacagcctg tatgttgttt ctgtttgtgc 1082281 atataacatg ctgatgggga gagaaagcag caaaagaagc aggacaggcc tgtatattgt 1082341 aaagctcgcg gacattttcg gggtaacagc tgggtgtagc ggctttgtct caggcagttt 1082401 cagtgcagcg atcagaaagt agataaacaa tgctgcagca tctaatgcga atatccacac 1082461 ggggttatga ttgtacagca gcatccccac tagcggtcct gccgtcagac ccgtcgaata 1082521 gatcgcattg atgaccgcaa acacttccga acgtctgctt tccggcgtgc tttcagcgat 1082581 ttgggcgcgg gaagcgggaa tgtacaacga tcttccgatg ccattcatga catagagaat 1082641 agcgaaaaca tacgcatgct cagcaaatac aaaccctgtc attgccgctg attgaagaag 1082701 caatgcggtc aaaatcgctg tgcgccgccc aagccgatcc gtcacccgtc ctgcagcgag 1082761 cgtcaggaaa atatcagcaa atggctgaag gctgatgatc agcattggca tcatgatact 1082821 gccgtttaat tgttcatgca gatacagcac cataaaaggt cccatcattg cacctgtcag 1082881 gcttgtcagc aattcgccga aaaagcggag ccgaacggga gcggtatatc tcgattttat 1082941 agagtgaaaa ctggtcaaca tgtgatcgcc gcctttcgct gtttgatata gtagtagtgt 1083001 atagaagggg cggcggccca aaaagtgaag aaaagaagag ataaaagttc cccttttgtc 1083061 gggaggtgcg gggattgaag ctgatagagc actacgtggc gcttgtaaaa acaggctgcg 1083121 ccgagtatgg gcaaatgaac gaaatgacgc tcactgagat tgccgactgt ttattttgta 1083181 cagaaagaaa tgcaaagctc attttacata agctggagaa cagcaattgg attatccggg 1083241 aaagcggggc ggggcgcggc cgcaaatcta aaatcgcgtt tcttcggagg cctgaggaac 1083301 tgcttcttca aactgcaaag gaatatacca tgtcaggaaa gcttaaaaag gcaaaggagc 1083361 tgcttcagca gtatcagtcc gcgtttccag ggcttcaaaa cgaatataac atgtggctat 1083421 cagaggtatt cggatttgtg acggagacag gcgagaatgg ggcgaaggat gtcctgcggc 1083481 tgttcatcac gcctgaatct gtcagcagtt tggatccatg ccaaatattt ttgcggtctg 1083541 agggccattt cgtcaaacag atatttgata cactcttcac gtttgattcg gatatgcagg 1083601 agccgaagcc tcatttggtt catggatggg aagaggtcgg aaaaaaacaa tggagatttt 1083661 ttcttcgaaa aggtgtgtta tttcataatg gacagccgct gacatcgcgg gacgttgcgt 1083721 ttacatttca gcgctttttg gaactggctg acaacccgta taaatggctt ctgcacggag 1083781 tgaaacaagt cttagaaaag ggcccttatt gtgtggagct catactcgat aagccgaatg 1083841 cgcttttgcc gtatgctctt tgtgatgaac ggctgtccat actgccggca gaacagggcg 1083901 gcgggaaaaa tggaacaggg ccttttcaga tgaatcagca acatagcggg atgcttgtgc 1083961 ttgaagccaa tgagcgctac ttcaagggac gcccctattt ggatcgcgtt gagtttgtgt 1084021 tttctgagca agccggagag atgaacggtt ttaccattca agaaaaacaa acatgtcctg 1084081 agcagcaaac tgtctttgat gagcggcatg ttcagtattt gtcgcttaat ctgaaaaaga 1084141 aggggcctct tcagcaccga agctttagaa aagcgctccg gctgctgatt tcctctgaac 1084201 ggctcgttcg tgaagcggga gggcaccgaa gaattccggt tacgtccttt ttgcatccga 1084261 gtccttttga gtgggagggc gtttcgccat ctgaattgtt gaaaaaaagc ggatacgagg 1084321 gcgaaacaat cgtgctttat accttttcgg aaacggatca tcgtgaggac gccgaatgga 1084381 ttcaaaatat ttgcgcccag cacggtatca ggcttacact tcaattctgt gatgctgctg 1084441 atctgcgacg gccggaaatc gtgcagatgg cggatatcat tcatgacagt gcgacgtttt 1084501 atcaagacag cgagtttggt tttctgcatt tgctgctgtc ggagaacagt ttcttgtatc 1084561 agcatctatc tgaaaagctg acacagattt gctcaggaat gacagagcgg atgttttcca 1084621 tgcctgaccg ctgttcgaga atcaacatcc tgcgtgacat tgaccggcag atgatacagg 1084681 agctgaacgc gatcccgctg tatcaaaatg tgctccaggt gacatcaagt aaaaatgtaa 1084741 aaggcctggt gcttgatgaa gagggatgga ttgatttgta ctccgtatgg ctgtccaaat 1084801 aaaaagaggg ttcttttttg aaccctcttt tttacgctgc catgctgcgg cattgttcag 1084861 cacaggtgaa gcaggctttc gcacatgctt ggcaatgatc atgatcgtgc tttccgcatt 1084921 cagtgccgca tgcttcacaa atatcggcgc aaagtgcaca aatttctttc ataaacgggc 1084981 tgtccgtttg catggctttg accgccagcg cgcaaatatc cgcgcattcc ctgtcaagcc 1085041 ggatgcatcc gctgagatga tgctgcacgc tttcttccaa gcatttagtg aaacaatgat 1085101 tgcaagcctt catgcaatcg atgcaagcct caatacaagc ctcagaatat tgctccatgg 1085161 ttgattcccc ctgtatgaca gtatatggtt ttatgtttca cggctgcatt tgaaaaaaac 1085221 aggggagtgt gtttttagct aaggggatat gtacatatac cctgaatggg tatatctaac 1085281 gttccatcag atagtatagg aaccagacag cgtgattttg ttcatcacgt gctgcgcgcg 1085341 taaagacgcc tttcgctttt aagtttgacg tttcctcggc cgcacgcaag taaaagtcga 1085401 cggtttcttg ttcatcttta aaagcggcgt ccagtcctct tgtgaaattg tccgggcatt 1085461 cttccgtttg tttcggcatg atgtgtttgc cggtaattga accatacagt gtggaaaatt 1085521 cacggaggtg gcgaatctcg tcacgcctga tttcttcaat ctgttttctg acctcatcgc 1085581 tgtgggcgag ttcggcaagc ttgcggtagc attgaatagc actgaattct ccgttgatgg 1085641 ccttctgcaa attccgaatc aaaacaggat cttcccggta tggcaccgga tagggatagt 1085701 agctgtaatg caaggggatt caactccatt cttaggaatt gggcttctgt aaaagtatat 1085761 gttgggcagg gagagatgtg cggagataat cagcttttta tatgtgaaaa ggccgttttt 1085821 accaatagat cagattggtc attttcgtca acattcgata aaatatagag agataaaaag 1085881 agaggggtct tctaatttgg gagcagagtt tttagtaggc aggtccggga gtggaaaaac 1085941 gaagctgatc atcaacagca ttcaggatga attgcgccgg gctccattcg ggaagccgat 1086001 catttttcta gtcccggatc aaatgacgtt tttaatggaa tacgagcttg ctaaaacgcc 1086061 agatatgggc gggatgatac gcgctcaagt gttcagtttt tcacgattgg cctggcgcgt 1086121 cctccagcat acgggaggaa tgagcaggcc gtttctgacg agcaccggcg tacaaatgct 1086181 cctgcggaag ctcattgagg agcataaaca ggagttcaaa gtctatcaaa aagcgagtga 1086241 caaaagcggg tttaccgcac aggttgagcg gatgctgaca gagtttaagc gctattgtct 1086301 ggaaccggag gatatccgcc ggatggcgga aagcggaacg gcttccgagt atcgcggaga 1086361 acgtgtttta tctgaaaagc tccatgactt atcaattctg tatcagcaaa tggaaaaaag 1086421 cctcgcagat caatatcttc actctgagga ttatttgaca ttgctggcag agcatatccc 1086481 gcttgcggaa gatataaaag gcgcccatat ctatgtggat ggcttttatc agtttacccc 1086541 gcaggaattc agggtgttgg agcagcttat ggttcatgcg gagcatatca cgttttcgct 1086601 cacagcggac aagccgtcat atgagcggga gccgcatgaa ctggaattgt tcagaatgac 1086661 ggggaaaacc tattaccgcc tgcatcagaa ggcgaaggaa ctgaatttgg acattacgta 1086721 taaagagctg agcgggactg agcggcatac aaagacgccg gaattggcgc atctagaggc 1086781 acagtatgaa gcgcgtccgg ccattccata cgcagaaaaa caagaagccc ttactgtgat 1086841 gcaggccgca aacagacgag ctgagctgga aggcattgct cgggaaattc acgccctagt 1086901 cagagagaag ggatatcgct ataaggatgt agcaattctt gcgcgccagc cggaagacta 1086961 caaggatatg gtgaaggaag ttttcgcaga ttacgagatt ccttatttca ttgacggaaa 1087021 agcatctatg ctgaaccatc cgttaattga atttatccgg tcgagccttg atgttctgaa 1087081 agggaattgg cgttatgaag cggtgtttcg ctgcgtgaaa accgaactgc tattcccgct 1087141 caatgaaccg aaggccaaag tgagagaaca ggtcgatcag ctcgaaaatt actgtatcgc 1087201 ctatggtatt aaaggcgacc gctggacaaa gggcgatcgg ttccaataca ggcgttttgt 1087261 gtcattggat gatgattttg cgcagactga tcaggaaatc gaaatggaaa acatgttgaa 1087321 tgacacccgc gattggattg ttccgccgct ttttcagctt caaaaacgca tgaaaaaagc 1087381 gaagacggtt caagagaagg cggaggcgct ctatcgttat ttagaagaga cggatgtgcc 1087441 gctgaagctg gatcaggaaa ggcagcgtgc tgaggatgac ggcagaatca ttgaagcgca 1087501 gcagcatcag caggcgtggg acgcagtcat tcagctgctt gaggagtttg ttgaaatgat 1087561 gggagatgat gagatttctc ttgatttgtt tcagcaaatg atagaagccg gcgcggagtc 1087621 gcttacattt tctctaattc cgcctgcgct tgaccaggtg tttgtcggca atatggattt 1087681 gtccagaatg tatggcacct cctgcacctt tgtgctcggg gcaaacgacg gcgttctgcc 1087741 ggcacgccct gatgaaaacg gggtcctgtc ggatgatgac cgggaatggc tgaaaacgat 1087801 tggggttgag ctatcctcag gcggacgaga gcgtttgctt gatgagcact tcctcatcta 1087861 catggcgttt tcaagtccgt ctgaccggct ttacgtatcg tatccgattg ctgatgcgga 1087921 aggaaaaacg cttttgccgt cgatgatcgt taagcggctg gaagaactgt ttccgcatca 1087981 taaggagcgc ctgttaacaa atgaacctga acaggtcagc gatgaggaac agctgatgta 1088041 tgttgtgaat aaaagcgtgg cacagtcctt taccgcgagc cagctcaggt tatggactcg 1088101 ggaatacgac atcagcgacg tctggtggag cacgtacaat gtgctgatga gtgagcagga 1088161 caggctgcaa tcgaaaaagc tgttctcaag cctgtttttc cggaatgaag tgaagcagct 1088221 tgaacgcagc gtgtcgagac agctctatgg tgaacgtatt cagggcagtg tatcgagaat 1088281 ggaaaccttt aacgcatgcc cgttttccca ttttgcgtca cacgggctgc atttgaagga 1088341 acggcaattc ttcaagcttg aagcaccgga tatcggccag ctgtttcatt ccagcttaaa 1088401 gctgatttcg gacaggctgc gtgagcaaaa gctggattgg cgcgatttaa cgaaggagca 1088461 gtgcgagctg ttttcctatg atgcggtaga gcggctggca ccgaaactgc aaaaggaaat 1088521 tctgctcagc tcaaaccggc attattatgt gaaggaaaaa ctgcaaaaaa ttgtgacacg 1088581 tgtgtccggc attttaagcg agcatgcgaa agcgagcgga ttcgtaccga tcgggcttga 1088641 actgggcttt ggaggaaaag ggccgcttcc gccgctgacc tttcaactga aaaacggctg 1088701 tacgatggaa ctcgtcgggc gaattgaccg tgttgataag gctgaaagct caaaaggcct 1088761 gctcctcagg attgtcgatt ataaatcaag cgacaaaggc cttgacttag cggaagtata 1088821 ttacggattg gcactgcaaa tgctgacgta ccttgattta tcgattacac attcagctga 1088881 ctggctcggg atgagggcga cgcctgccgg agtgctgtat ttccatattc atgacccgat 1088941 gattcaatct aatctcccgc ttgggcttga cgagattgaa caggagatct ttaagaaatt 1089001 taaaatgaag ggcttgctcc tcggtgatca ggaagtggtt cgcctcatgg atacaaccct 1089061 tcaagaggga cgttcaaata tcataaacgc cggcttgaaa aaagacggct ctctcagatc 1089121 agactcagca gcagtcggtg aaaaggaatt tgatcttttg acaaagcatg tgcgccgcac 1089181 cttccaagaa gcgggcgaac aaatcaccga cgggcgcgta tccattgagc cgtacaaaat 1089241 gaagaacaag acgccgtgca catactgtgc gttcaaatca gtatgccaat ttgatgaatc 1089301 actggaagaa aacgagtatc gcccattaaa ggctgaaaag gacaagacaa tacttgagtg 1089361 gataaaaaag gaggcggatg gcaatgaaca ttcctaaacc ggcagacagc acatggacag 1089421 atgaccaatg gaatgccatt gtttcaaccg gccaggatat tcttgtggca gcggctgcgg 1089481 gctctggtaa aaccgctgtg ctcgttgaac gaatgattcg gaaaatcacc gcggaggaaa 1089541 acccaataga tgtagaccgt cttctcgttg tgacatttac aaacgcctca gcggcagaga 1089601 tgaagcaccg aatcgcagaa gccttggaaa aagagcttgt acagcgcccc ggctcgctgc 1089661 atattagacg ccagctgtct cttttaaacc gggccagcat ttcgacgctc cattcctttt 1089721 gcctgcaagt gctgaagaaa tattactact tgatcgatct tgatccgggc tttcggatag 1089781 ctgatcagac ggaaggcgag ctgatcgggg atgaagtgct tgacgagctg tttgaagacg 1089841 aatacgcaaa gggcgaaaag gcgttttttg agcttgttga ccgctatacg acagaccggc 1089901 atgatctgga tctgcaattt ctcgttaaac aggtgtacga gtattcccga tcccatccca 1089961 acccggaggc gtggctggaa agctttgttc atttgtatga tgtatcagaa aagagcgcca 1090021 tcgaggagct gccgttttat caatatgtca aagaagatat tgcaatggtg cttaacgggg 1090081 cgaaggaaaa gctcttgcgc gcgcttgagc tgacgaaagc gccgggcggc ccggcgccgc 1090141 gtgctgacaa ttttcttgat gatcttgctc agattgatga actgattcag catcaggacg 1090201 atttcagtga actatataag cgggtgcccg ccgtctcttt taagcgtgcc aaagcagtaa 1090261 aaggggatga gttcgatcca gcgctccttg atgaggcgac agatttgagg aacggcgcaa 1090321 aaaaactgct tgaaaagctc aaaaccgact acttcacgcg aagtcctgaa cagcacttga 1090381 aaagcctagc cgagatgaag cctgtcattg aaacgctcgt acagcttgtc atcagctatg 1090441 gaaaacgatt cgaagctgcg aaacaggaaa aatcaatcat cgatttttcg gatttggagc 1090501 attactgttt agcgattttg acagctgaga atgacaaagg tgaacgtgag ccgagcgagg 1090561 ctgcaaggtt ttatcaggaa cagtttcatg aggtgctcgt tgacgaatat caggatacca 1090621 acctcgtgca ggaatcgatt ctgcagctcg tcacaagcgg tccggaggag actggtaacc 1090681 tgtttatggt aggagatgtc aaacagtcga tttatcgatt caggcttgcg gagccgcttc 1090741 ttttcctctc taaatacaaa cggtttacag agagcggaga aggcacgggg cggaaaatcg 1090801 atttaaataa aaatttccga agccgggctg atattttaga cagcacaaac tttttattta 1090861 aacagctgat gggcggcaaa atcggtgagg tcgattatga cgagcaggct gagctgaagc 1090921 ttggtgcagc gtatccggac aatgacgaga cggaaacaga gctgctgctg atcgacaacg 1090981 cagaagatac ggatgcaagc gaggaagcag aagagcttga aacggtgcag tttgaggcaa 1091041 aagccatcgc taaggaaatt cgtaagctga tttcatcgcc gtttaaggtg tatgacggaa 1091101 aaaagaaaac acatcgcaat attcaatacc gagatatcgt gattttgctc cgttcgatgc 1091161 cgtgggctcc gcaaatcatg gaggagctga gagcacaggg cataccggtt tacgccaatt 1091221 taacgtcagg ctattttgaa gcggtcgaag tcgccgtcgc gctttctgtg ctgaaggtga 1091281 ttgataatcc gtatcaggat ataccgcttg cctctgtgct gcgctcaccg attgtcggag 1091341 cagatgaaaa cgagctgtct ttgatccggc ttgaaaataa aaaagcgccg tactatgagg 1091401 cgatgaaaga ctacctggct gctggtgacc ggagcgatga gctttatcaa aagttaaata 1091461 cgttttacgg acatctgcaa aaatggcgcg cgttttcgaa aaaccactca gtatctgagc 1091521 tgatttggga agtgtaccgc gacaccaaat atatggatta tgtcggcggc atgccgggcg 1091581 gaaaacagcg ccaggccaat ttgcgtgttc tttatgacag ggcgcgtcaa tatgaatcaa 1091641 cggcatttcg cggcttgttc cgtttcctgc ggtttatcga acgcatgcag gagcggggcg 1091701 atgatcttgg tacggcgaga gcgctcagcg agcaggagga tgttgtccgc ttaatgacga 1091761 tccacagcag caaagggctc gaatttccag tcgtgtttgt agcaggtctc ggccggaatt 1091821 tcaacatgat ggatttgaac aaatcgtacc tgctggataa ggagctcgga tttggcacga 1091881 agtatattca tccgcaatta cgcatcagct atccgacact tccgctcatt gcgatgaaga 1091941 aaaaaatgcg cagggagctg ctgtcagagg aattgcgtgt gctctatgtt gcattaacga 1092001 gagcgaagga aaagctgttt ctgattggct catgtaagga tcatcagaaa cagcttgcaa 1092061 aatggcaggc atccgcgtcc caaactgatt ggcttctgcc ggaatttgac cgctatcagg 1092121 cgagaacgta tctagatttc attgggccgg ctcttgccag gcacagagac ttgggggatt 1092181 tggctggtgt gccagcacac gctgacatct caggtcaccc ggctcgtttt gccgttcaaa 1092241 tgatccattc ctatgatttg cttgatgatg atctggaaga aagaatggaa gaaaaaagcg 1092301 agcgcctaga agcgatccgc cgaggtgaac cagttcccgg ctcgtttgcg tttgatgaaa 1092361 aagcccgcga gcagctgagc tggacctacc cgcatcaaga agtgacgcaa attcggacaa 1092421 agcaatcagt ttctgagatc aagagaaaaa gagagtacga ggatgaatac agcggcaggg 1092481 cccctgtaaa accggctgat ggaagcattc tgtacagacg tcccgctttt atgatgaaaa 1092541 aaggcctgac agcggcagag aaagggactg ccatgcatac ggttatgcag catatcccgc 1092601 tgtcacatgt gccgtcgata gaagaagctg agcagacggt tcacaggctt tatgaaaaag 1092661 agcttctcac tgaagaacaa aaagacgcta ttgatataga agaaatcgtg caatttttcc 1092721 atacagaaat cggcggacag ctgatcggtg ctaagtggaa ggaccgggaa ataccattca 1092781 gcttagcgct tccggccaag gagatctatc ctgatgcaca cgaggcagat gagccgcttt 1092841 tagtgcaggg tattattgac tgtctctatg aaactgagga cggattatat ctattggatt 1092901 ataagtcgga ccggattgag ggcaaattcc agcatggatt tgaaggagcg gccccgatct 1092961 tgaagaaacg atatgaaacg caaattcagc tgtacacgaa ggcagtggag caaattgcaa 1093021 aaacaaaggt aaagggatgt gcgctttatt tctttgacgg agggcacatt ctgacattat 1093081 agcgagatcc ataagctccg gaatttcagg cggagcgggt ctcgttttct atataaaaga 1093141 gaggtgaaag catttgcgga ttttacatac ggctgactgg catcttggaa aaacgcttga 1093201 aggaagaagc aggctgagtg aacaggccga tgtgctggat gaactgaata cgattgtaaa 1093261 ggatgagcag atcgatgcca ttgtaatggc gggggatgca tttgacaccg taaacccgcc 1093321 agctttagcc gagcagctgt tttatgaaag cctgtctgcg cttagcgaca gaggaaagcg 1093381 cccgatcgtc gtcattgccg gaaatcacga taatcctgac cgtttgtccg ccgcttcacc 1093441 gctgacacat gaaaacggca ttcatttaat cggttatccg acaacagagc cgattcatat 1093501 tgaagtgcct tcagcaggag agcttttggc ggttggagcg ctggcgtacc catctgaagc 1093561 gcggttaaat gaagtgctat ccgatacgtt tgatgaaaag ctgctccgtg atcactatga 1093621 tgtgaaaatc aggcaggcgt ttgagcatat gacaagccgg ttccggaccg atgcagtgaa 1093681 gattgccgcc agccatattt atgtggcagg cggaaaccaa accgattcag agcggccgat 1093741 tgaagtcggc ggtgcataca cggtggctgc tgaaagcctg ccggcagatg ccgcttacgt 1093801 tgcgctcggc catttgcatc gcccgcaaac gatcaagcgg gcgcggacgc ttgcgcgtta 1093861 ttcaggatct ccgctcgcct acagcttttc tgaagcgggc tacgctaaat cagtgacgat 1093921 tgtggacgca aagcctgggg aagaggccac ttggcaagag gtgttattat caagcggcaa 1093981 gccacttgtg aagtggaaag cggcaaatgg attaagtgag gtgtacagct ggctggatga 1094041 aggcagagat cagaatgctt ggattgactt ggaaatccgt gtcgcggacc agctgtcact 1094101 tgaagagatt cacaggctgc ggaaggcgca cccgggcttt atccatatca ggccggtttt 1094161 tgaagaacag aacaaagacc gggaacggat cgaggttaaa catgtctcaa tcgaggaccg 1094221 ctttaagaaa ttttatgaaa aacaaactgg cggtgcggtg ccggatgaag aaatggtgaa 1094281 gctgttttta gagcttgcat caggcgttga agaggaggat gcgaaatgaa gccgatcgcc 1094341 ttaagcatta aggggctcca cagctttaga gaggagcaga cgatagattt tgaaggcctt 1094401 tccggtgccg gtgttttcgg cattttcggc ccgacaggaa gcggtaaatc ctctatactc 1094461 gacgcaatga cgcttgcttt atacggaaag gtggaacggg cggcgaataa tacgcacgga 1094521 atcttaaatc acgccgaaga tacgctgtct gtgtccttta cctttgcgct tcagacgaat 1094581 caccaaatct catacaaagt cgagcgtgtg tttaagagaa cggatgaaat gaaggtaaaa 1094641 acggcacttt gccgcttcat cgaaatcaag gacgagcata cggtgctggc tgataaagcc 1094701 agcgaagtga ataaaagagt ggaggagctc ttagggctga cgatcgacga ttttacgaga 1094761 gcggtggtgc tgccccaagg gaaatttgct gaatttctgt ctttaaaagg ggcagagcgc 1094821 aggcatatgc ttcagcgttt atttaatttg gagcaatatg gagacaggct tgtgaaaaag 1094881 ctgagacggc aggcgcagga agccaatgcg agaaaaaatg aaatgcttgc tgaacagtcc 1094941 ggtctcggtg aggcgagctc agaggcagtg gagcaggctg aaaaggttct cgaacaagct 1095001 gaagcccggc tggaagcgat gaggaagaac cgtgatcagg cgaaggagcg gtttacagag 1095061 catcaggaga tatggaatgt ccaaaaggaa aaatccactt atgaagaaga ggaaaaacgt 1095121 ctcgcagaag aacagccgca tatagacagc atgcaaaaac gcctgctgga agcagaaaca 1095181 gcagcagccc ttaagcccta tgcggaccgg tacgcagaag cgatccagca tgaggagcaa 1095241 gctgaaaagg aacaaacgct agcccaaaag gatttagcag accggacagc tttctttcag 1095301 caaaaacatg aagagtatga agcgtggcgc cagcataaaa gcgagaaaga gcctgagctt 1095361 ttagccaaac aggaacagct ttcacgcttg caggaaatcg aaatcaaact gagtgaggcc 1095421 aagcaagagg aagagcgcaa aaaggctgac ctccggcaga aagaagaggc tcttcaatct 1095481 gtcatgaatg aattagagac cgtaacagac cgcctgacac gagggcaaaa cagacagaca 1095541 gaattgaagc agcagctcaa atccctgcag gtgacatccg atgagcgaaa aagctgccag 1095601 caggccgcag agatggcatt gcgcatcaga caaaccgagg aacaaatcaa aaaagagaaa 1095661 aaacgaagtg aagaattgaa cctcgtgctg cagaagatga atgaagagaa gaatacactc 1095721 gttcaaaaga cggaagcgga agaaaacaac atcattcagg catatgaggc agttcaaact 1095781 gtgtaccatt tggtgtgcga aacggaacgc tcattaacac gtatgacgga agaggctaga 1095841 aagagtcaac acacgcttca cttacagcgt gaaaaagcaa gggtggcact gctgacaaaa 1095901 gagttagccc aaaagctgac tgccggaaag ccttgcccgg tatgcggttc aaccgatcat 1095961 gatccatctg cctcggtaca tgaaacgtat gaagccgaca gccatcttga agaggacatc 1096021 aaacggacag atgtgttatt gacggaagct gcagctctca gccaggagat tctttcagcc 1096081 aaaattatgc ttgaagaaca gtccgcgcgc tttattgaac agtgtccgtt tttgcagaca 1096141 attcaagcac agaaccttga agcggcagct tccttcgaac atcagccggt gtatgaagca 1096201 tttgaaactg ccaaatttga atggaaacga atcaagcagg acattctttc tgttaagaca 1096261 cgaatggcac aaatgattgg cgcctatcag gagtctttaa aaaaggccga gcagcttaat 1096321 gaaaaaatcg gttttgaaaa aagagaagcc gaccgtattg aaagcatcat cagtgagctt 1096381 caatcctcaa tggacagcag tctgaacatg tttaaagaag catttcagaa tcaatctgtg 1096441 gacgaagcag aaaaatggca gcaagccatt gaagaaaagg accgggctgc agaagaatgt 1096501 gaaaaacgaa ttgagaagag tatcgcgttt cttgctgagc atgaagcaca aaaggaaaaa 1096561 ctgcgggaat cgggacaccg gcttgagcgg gaaaagctgg agcttcatta tgcggctgaa 1096621 cgcatcaaga gcgtgatagc tgattatgag cacgaactcg gagattatgc aaaaggagat 1096681 tcgattcaaa tcaaactccg ctctgtccag caggatctaa agctgttaaa ggaaaaagaa 1096741 caatctttat atgaagaact gcaaagcgcc caaatgaagc tcaaccaagc gaaaagccgc 1096801 gcttctgcaa gcgagctcac tcttcaagag gcgaagggca gattggaaaa agcaaaagct 1096861 gcttggcttg agcatacaaa aaacacctcc attacccgga ctgaggaggt tgaacaaagt 1096921 ctcatcccag ctgatgaact tgaaaagatg aaaaccggca tagaccagtt tatggataaa 1096981 ctgaagcaaa atgctgcaaa cttaaaacga gtagcagaga tacttgccgg cagagcatta 1097041 tcagagagcg aatggaacga aaccgttgca gcattacaag aagctgagga cgcatttggc 1097101 gctgctatag aggaaaaagg cgcggccgca aaagcactgg ctgtcattcg cgaccatcat 1097161 aaacggttta atgaaattga agctgaactg aaaaaatggc agatgcatat cgacaggctg 1097221 gacaagctgc aagctgtgtt taaaggcaat accttcgtcg aatttttagc tgaggagcag 1097281 cttgaaagcg ttgcgaggga cgcctcagca agactcagta tgctgacaag acagcgctat 1097341 gccatcgaag tagattctga gggcggcttc gtgatgcggg atgacgcgaa tggaggcgta 1097401 cgacgcccgg tttccagttt gtctggagga gagaccttcc tcacctcgct ttcacttgct 1097461 cttgcgctgt ctgcgcagat tcagcttcgg ggggaatacc cgctgcagtt ctttttctta 1097521 gatgaaggct tcggcacact ggatcaagat ctgcttgata cggttgtaac ggccttggaa 1097581 aaacttcagt cagacaacct ggctgtcggt gtcatcagcc atgtgcagga actgcgtgca 1097641 cggcttccga aaaagctgat cgtccatccg gctgaaccga gcggccgcgg tacgcgggta 1097701 tcacttgagt tgatgtaagg gaggagcgga tatggcaaag cagattgccg gaatatgtga 1097761 gctgtgcggc cggagcgatg tccagctgac agagcatcat cttacaccga aagaggaagg 1097821 cggaacgttt ttgccgacag cgatgctctg tattccttgt cataaacaga ttcatgcctt 1097881 atataccaat caagagctcg ctgtacgttt aaatggaatg gctgaactca gaagcgatcc 1097941 agagcttgcc cggtttgtca aatggatcag aaaacagccg cctgagaagc tgatcaaaac 1098001 taagaaatca aatgaacgaa aaaagaaaaa atgactaaaa agcagccctc tctttgcaga 1098061 gcggctgctt ttatccgttt ccaaccatat cctgatcgtt gacatcgggg tctatataat 1098121 ttgtcgcgtt gactgcatta tttaatagaa ggaaatctcc cgtgtttcct gctcccgaac 1098181 cgagcgcaga ttttgaagag cttttcggag aaaggtaaaa ggaatcacca aagtttacga 1098241 ctccgcccga tatggaattg atagctatag gcccgacaat tgctggcata aacgacaccc 1098301 tttatcgaag tctctgttta ttatatgttc ttggcgggcg attgtgagcg cggagactga 1098361 atctgtctga tatgtttgag tctcgcatca ccgcgaataa gcgaagctga tccggcatgt 1098421 aaaacagaag aggctgagac cccttgaatt ttgatgctgc gaacataaat agccggcacc 1098481 tcgtggcaaa acgcgctttg tacacctgtt tcggggagcg gcttcacggc ctgctgctga 1098541 aagatctgat actccttttt gttaaatgag ccttcattat ggtaaaacgt ggacagagaa 1098601 cgctgcacag caaatacttt tacactcata tcgatttcat ttgtgtcgcc aacttgaaac 1098661 acacttgcga tcccgagaga attaaactta actagtctga tgcgcgatat gcgtttaagc 1098721 attattctgg cgcaagcgga gcaaacggcc caataataag agattcaggc ggtgtatcaa 1098781 aaatagaaga caggtagatg gattcagtgt ctccgatgtg gaaaacggag gaactggaca 1098841 caccgttcat ccgaatatcc ccgacttcca agctgcggtt gatgactgta aagatcatgc 1098901 ttgctcatct cctttcattt ctgatggaat atgctccaga aagtgttcta cagcgcggat 1098961 gacatcacgc ttcacatgct cagcgatatg ttctgcatat tgtgcaggcg gtgtattttc 1099021 ttcttttttg atatgggaca tataatagtg aatcctgctg tccatttgtt ttctgatgtc 1099081 ttcaataaca tgatgtctgt ttgtatcgtc aagtctgctg tcatattgat tttcaagctg 1099141 ttccaaaata tctgggattt cctcggttaa gtacatgtcg acattctggc ggatctgctg 1099201 catgagctga gcgctctctt cctgctgcat catcccgatt tgcggtgtcg actggctgac 1099261 gtcaaagttt tggacgctgt tcgggtcagt cggatttaaa ccgatattca aagtcccgtc 1099321 gagcctttcg attttcagct gatcaaattt atactccaca cgctcaatgg tagtggccgg 1099381 ccgctgtttc atcgtattca tttcagtttg aatctctttc agctgacgtt cgagctgctg 1099441 aatgtgaatc gcctgctgct gaacgaagga attcaagttt tgcaggtaag aggaaacaga 1099501 ttgatcatac atgttcttca cctctttcat atgattaacg gccaggaggc tggagcggga 1099561 ccaatgaacc tgtgtcgggc tcctgcagct ggagcggttg ccctgagcca gaaacttctg 1099621 gtgccggctc tacatagctt cctgtattat acaaatttga cagtgacttg attgatccgg 1099681 cgctcccgat ttgcagaatg gaggagttgc tgattgattc cagccggaga tagttgattt 1099741 gaatggtttg attaatatag aagttcatga gcctcactcc ttttacgcat tggccacgat 1099801 cggctgatca accgcatcat tgtcatacac attcgtcgcg ttttgataat tcatcacctt 1099861 gaggctgtcg ccggtattaa agctgccagc accggcaaac gttctgacct gagcctgagg 1099921 agaaatcgta atgcagtccc cgatgtgaac gactccgctc gtaccaatcg cattaatttt 1099981 aaacgctccg acaatggccg gcatacgagc acatcctttg ttgaaaaatt aaaaaaagac 1100041 aggtaaagtg aaatgacaat tccgatttca attgggctat tcacgatagc ttatgacaaa 1100101 cgcacatatg tgtgagagaa attttaaggg gacatatcgg ctctttgtga aagcgtttta 1100161 ttttttcggg ccgttatgtt taaacatggc aaaagaggat gttgggtata aattgagcgg 1100221 aaatgcggcg aaggatgccg ctatccgcct atggtgattt ttgtttattt ctttggtgtt 1100281 tttgcgtgta gaatgctttt tggagtatgt cgtgctgcgg tattcgattt ttgggcgggc 1100341 acattctcgc cctgaggtat atctcagaag tgctgagcaa aaatcggagt taaatgtggt 1100401 gtattctaat tgttatagaa aatgatttac atacgggagt tttcaagata tctcccaaaa 1100461 atcatttctt ctttaatccg ggtattcagc aggatatcca gctcttggct gcattgaatc 1100521 gtttcttttg aattcatgcc gtatttttgt gcggtttcaa ttagtgtgat cctcatttct 1100581 tcaattttac tgttcattac gctatctcca attctagatt ttattttgat ataaatacag 1100641 gatatcgtta gtataaccta ttttggctca aaaggttgcc tttcgtcaat ttgactaaaa 1100701 aagcgacaat ttttgctgcg gcctttttta atggagaaag gactaaagtc ttgctaagtg 1100761 tgcttgcaaa aagtcctgcc gttcctcaat ttctctaagt atgttggtct gctccttttc 1100821 gatttgaaag gggctttttt tgataaaagg atcatcagca gcactttgac aaatgtcaag 1100881 gtgccattcg ttgatgagag gagataatcg ttcaatagta aacgaccgct tcagcacgtt 1100941 tttcattaag gtgtgatatt gcgacctgaa ggcgggaatg gatagaagcc ttgacgaaag 1101001 cgtctttcct tttgtcagaa gcgggtcttc ttcataccat tcttgtacgg caagcgatct 1101061 tgtctccatc ggggaaacgt aaagccgacc ggattcgttt aaacaaaatg tgtagtaaaa 1101121 gccttgattg gtgcaggtgt tgccgatcag ccacaaaaaa aacagcttga catccagata 1101181 caatttaatc ctttcagcca attcgtcatc tccggctgtg cggatcagta tgaaaaattc 1101241 atgtaagaat gccgaggaat cattgttaaa aagggacaat ggaacccttg gatcggccgt 1101301 cttcactccg taactccttt taccggctgg ctgatggttc ttgatgttca aataaatgcc 1101361 ttcaggctgg ccattgatgg tcagaaagct gtacgaggca acgggagcag gtacgccgat 1101421 ctggtcaaaa aaacaatagg cgagtctgcg ccgcatcagg gacggatcat cctgttctgc 1101481 attcaaaaaa agtgtccttt caccaagcag agacttttcc cagctgattt cataggatgc 1101541 cttttccgct ctgtcacgct gtgtgagaag aatgggagaa acagatcgat ctgttacgaa 1101601 aagccccttg gctgtacctt tccttttcag ctgctcccga tgaaaaaata aatgcacgcg 1101661 ctccatattc tttcctcctt ctcaaaacga catttgtatg atatgtagag caagcccgtc 1101721 ctgaaacgaa atgaaaacgg aattgagaaa aagggatttc agcattcgac agagaataca 1101781 tgaaggagca ttctgattta aaagatgatg gaggaataac atgaaatttg cgacagggga 1101841 actttacaac cgaatgtttg tcggcctgat cattgacgat gagaaaatta tggatttgca 1101901 gaaggctgaa aaaaaactgt ttgaacttga gacgattccg ggatcgctga ttgaatgtat 1101961 cgcagaaggg gataaattcg ttgcgcatgc aaggcagctg gccgagtggg caaagaaacc 1102021 gaatgatgag ctgggatcat ttatgtattc attatctgag gtgaagctcc atgcacccat 1102081 tccgaagcca tcaaaaaata tcatctgcat cggcaaaaac taccgggatc acgcgattga 1102141 aatggggagc gaggctgata ttccggagca tccgatggta tttacaaaat cgccggtaac 1102201 ggttacgggg catggtgata tcgtaaagag ccatgaagag gttacctctc agcttgatta 1102261 tgagggagaa cttgctgtcg tgatcggaaa aagcgggact cgcatttcaa aagaagatgc 1102321 atatgaccat gttttcggat atacgattgt gaatgatatc acggcgcgtg atctgcaaaa 1102381 aaggcataag cagtttttta tcggaaaaag cttggatacg acatgtccga tggggcccgt 1102441 gcttgtacat aaatcatcta ttcaggagcc agagcgcctc aaggttgaaa caagagtcaa 1102501 cggcgagctg cgccaatccg gttcggcaag cgatatgatc ttttccattc cggaattaat 1102561 tgaaaccctc tcaaagggga tgacgcttga agcgggcgac attattgcca ccggtacgcc 1102621 gtctggtgtc ggcaaggggt ttacgcctcc aaaattcttg cggtcaggtg acaaaattga 1102681 tattacaatt gatccgatcg gaacgctgtc aaaccaaatt ggctgaataa aactggaggg 1102741 cggacccgga cccgcccgtt ttttctgata atcatctttg tgacagagga caagttcatg 1102801 gtactataag tggggtaatt tatctgatag ggggaacata tatgacacac ctacatatta 1102861 cgacatgggt ggtagcgctg attctgcttt tcgtcagcta ctcgctgtat tcgtcaggaa 1102921 gtgcaaaggg cgcaaaaatc actcatatga ttctgcggtt attctatatc cttattattt 1102981 tgacaggagc tgagctgttt gtccgtttcg ccaactggaa cggagaatac gccggcaaaa 1103041 tgattctggg cattatcacc atcggcctga tggaaatgct cctcatccgc aagaaaaaag 1103101 aaaaatcaac aggaggcctg tgggtcggct tcgtcattgt ccttttgctg acagtgctgc 1103161 tcggtctgca tttgccaatt ggttttcaat tgttttaata gaaaaaccta tgaacccggc 1103221 tctttgatag agctggtttt ttttatattt atcccctcat attccaaatc atttaaaata 1103281 accttaaaat tccctgtaag cggtatctcg tcctatgaaa ttatgatacc ttcaaggaga 1103341 ttcattattt tgcaggaggg ataacatgaa acgcagaaaa ttcagctcgg ttgtggcggc 1103401 agtgcttatt tttgcactga ttttcagcct tttttctccg ggaaccaaag ctgcagcggc 1103461 cggcgcgatc gatcaggcgg ctgctctgga aaacggcaaa gagcagacag gcgccatgaa 1103521 ggagccggaa caggtgaaat ggtacaaagt gaccccggga gcaacggata ttcagaaaaa 1103581 ctcacatatg gcactgaccg taaagagtga ttcagtactg aatgtatctg tatatccaag 1103641 taaggaaaaa gcgcttaaag atgagacgtt tgagatgtac cgttctttca cagcggagga 1103701 tggaaaaagc gaagtcattt ttccatacgc gtggagcggc ccttactatg taaaagttga 1103761 atacctcgga gaagaagaac cagaggacgg cggaacggca gaagcagctg cagaagccaa 1103821 gtatacgatt gggtataaag gcaccaaaaa acagccgtca gatttagaag aggaagaagc 1103881 ttgtccggtt gaaatgagtg tcgatcagaa gaaatcagga aaaggcatcc tggataagtt 1103941 gagatcgatt cgtgatgagc agctgagcca aacagcagaa ggcaaagaac tgacaagcct 1104001 ttattacaaa gcagcaccgt ttatcgttgc aaagctcgca ctcaataaaa cagcaagaaa 1104061 tgaaatctat caggatcttg tgacattaaa gccgttattt gacgatgtgt cagaaaacgg 1104121 agcatcatct tcgtataagg tcactgaaaa ggatcaaaaa gcgatcaacc ggctatatga 1104181 taaagcttta caatcagtcc cgtcattcct taaagaggag ataaagaaac aagcggaccg 1104241 actaaatatg aagcagctgc aaggcaaaac agcaggagcc attttaacag aaaacaatat 1104301 tgcagcaaaa agtgaagttc agacaacaaa ggttattttc aaggtgaagg acaataaaag 1104361 cctctcatcc gtacataatg aaatgaaggg cttttctgca agcgcgcaat cgaaaaaaga 1104421 catatctaat gtgaaaaagg caaagaaact gtttgacaat ctgtattcat ttgaacttcc 1104481 gaaagacgag aaacagaacg gcgcatatac ggcaagcgcc aaaagggtca aaagcgctgc 1104541 tgcgacacta tccaagatgt ccaatgtaga gtttgcggaa cccgtacagg aatacaaaag 1104601 cttggcaaac gatattcagt acccttatca atggccgctt aaaaacaacg gtgaaaacgg 1104661 cggtgtcaaa aatgcggatg tgaaatatga gcctgccaac acattgctgt ccaaacgcaa 1104721 gcttaacgat acactcattg cagtagtaga cacaggcgta gacagcacgc ttgccgattt 1104781 aaaaggaaaa gtaagaacag atctcggaca caattttgtc ggacgaaata acaatgcaat 1104841 ggatgatcag gggcatggga cgcatgtcgc aggcattatt gcagcccaaa gcgataacgg 1104901 ctattcaatg actggattga atgccaaagc aaaaatcatc cctgtaaaag tgcttgattc 1104961 cgcaggttcc ggagatactg aacaaattgc tctcggcatc aaatatgctg ctgacaaagg 1105021 agcaaaggtg attaatttaa gtttaggcgg aggctacagc cgcgtgcttg aatttgcttt 1105081 gaagtacgca gctgacaaaa atgtcttgat tgccgcagcc agcgggaatg atggagaaaa 1105141 tgccttatct tatcctgcat cttctaaata tgtgatgtca gtcggcgcaa cgaatcgcat 1105201 ggatatgacc gctgatttct ctaactatgg aaaaggtctg gacatctctg ctccagggtc 1105261 tgatatcccg agcttagtgc cgaacggaaa tgtcacgtac atgagcggaa cgtctatggc 1105321 gacgccatat gctgccgccg ctgcgggact gctgtttgct caaaatccta agctaaaaag 1105381 aacagaagtt gaggatatgt tgaaaaagac ggcagatgat atttcctttg aaagtgtcga 1105441 tggcggagaa gaagagttgt atgacgatta tggcgatccg attgaaattc cgaagacacc 1105501 tggtgtagac tggcattcag gctacgggcg gctgaatgtc atgaaggctg tcagcgcagc 1105561 tgatttacag cttaaggtca acaagctgga aagcactcaa acagctgtca gaggaagcgc 1105621 gaaggaaggc acccttatcg aggtgatgaa cggcaaaaag aaactcggca gcgccaaagc 1105681 cggaaaagac aatgcgttca aggtgaatat cgcgactcaa aaacaggatc aagtactgta 1105741 tctgaaagca acaaaaggcg atgcgaaaac atcgtataaa gttgttgtcg tcaaaggaaa 1105801 accttccggc acaccgaaag taaacgcggt gaaaacgaag gatacggcag taaaagggaa 1105861 ggcaaacagc aaagcgatga tcagagtgaa aaacaaatca aagaaagtca ttgcttctgc 1105921 caaagctgac gcaaaaggaa cgttttcggt gaaaatcaaa aaacaaaaag ccggaacggt 1105981 gctgtacgtc acggctgtgg atacagataa aaaagaaagc aaggaagcaa aagttgttgt 1106041 tgaaaagtaa ccaaaaagcg gtgctcgatg caccgctttt ttatttgcgc ccccgttgga 1106101 ctgctgtgta cataatggat cgctttccgt ttgaagccgt ccattcaaaa cggtctcctg 1106161 tcccttcgct gctgtagttg tagtgatgct gcatcgcgca ttgtgcggtg tcatttgaaa 1106221 agtgataaaa ggacacaccc tgccccgccg aagtattcga aaagactcct ttattataag 1106281 aaaagacgca atcgaatacc gataagccga agctgtgcaa gtgctgcaga aatgcgagaa 1106341 aggtttcgtc gtcaagcgaa tccaaaagcg ccatgagcgg ccgcttgact gatttctcat 1106401 agcggatgcg ttctccgccg gaaagggaga tgttttctgc accgcatgcc aaaaccaact 1106461 tgtcctgaaa gccggcttgc tcccactttc ctttatgatg gatccagatt gggctgtgtt 1106521 ggagactgtc cgccagcagt atatcgcctt caccgttttc gattaagcag atgccgtctt 1106581 caatgaggat ggtgccgtat tcccactttc gttcctctgt atataacaat tgtttccgtt 1106641 tcatccatgc tgtctccttt ttcttcattc ctctcttttc tttccaattc aagcctgtcc 1106701 catacaactc ttttatggac aaatcaacta tctgcctata gatgcataaa cttactaagg 1106761 tgctgaaaga aacgaaattg ttacgaaaga aacgggattg gagctgatgt cacatgtgtg 1106821 gaattacggg ttgggtcgat tttaaaaagc agctcgtcca ggaaaaacaa acgatggaca 1106881 gaatgacaga cactctttcc aaacgagggc ctgatgattc aaacgtttgg ggggagcacc 1106941 atgttttatt cggacataaa agacttgcgg ttgttgatat tgaaggcgga cgccagccga 1107001 tggcgtgtac ctataaaggc gatacgtaca ccattattta caatggcgag ctttataaca 1107061 cggaagattt gcgcaaagaa ttgcgggcgc ggggccatca attcgagcgt acgtcagata 1107121 ccgaggtgct tctgcacagc tacatcgagt ggcaggaaga ctgtgtcgac catctcaatg 1107181 gcatattcgc tttcgctgtg tgggatgaaa agcgtaatct gttgtttgcc gcgagagacc 1107241 gtctcggtgt aaagccgttt ttttacacga aggaaggctc ttcatttctc ttcgggtcgg 1107301 aaatcaaagc aatcctcgcg caccctgata taaaagcgcg agtggacaga acgggacttt 1107361 ctgaaatttt cggtcttgga ccgtccagaa ccccgggcac tggcatattt aaaggcataa 1107421 aagaaatccg cccggctcac gcgctgacat tttccaaaga cggacttaat atttggcgtt 1107481 attggaatgt tgaaagcgaa aaacatacgg acagttttga tgacacggtt gccaatgtca 1107541 gatcgttatt tcaggacgcg gtgacgcggc agcttgtgtc ggatgtgcct gtttgcacat 1107601 tcctatcagg cggtctggac tcaagcgcga ttacagcgat tgcggcgggc cattttgaaa 1107661 aggaaggaaa agcaccgctt catacttatt cgattgatta cgaagagaac gataaatatt 1107721 ttcaagcaag cgcttttcag ccgaatgatg acggaccatg gattgaaaaa atgacagagg 1107781 ctttcggcac aacgcaccac aaatgcgtca tcagccaaaa agacctcgtt gatcatttgg 1107841 aggaagctgt actggtcaaa gacttgccgg gaatggcaga tgtcgactca tccctgctgt 1107901 ggttttgccg ggaaatcaaa aaggactttg tcgtcagcct atcgggagaa tgcgcggatg 1107961 agattttcgg cgggtacccg tggttccata cggcagatgt tgagtctggc tttccatgga 1108021 tgagatcaac ggaggagcgg atcaagctgc tttctgactc atggcagaaa aaattgaatc 1108081 tgaaagaata cgtaaatgcc aaatatgaag aaaccttggc agaaacgcca ttattagacg 1108141 gagaaacggg tgtggataaa gcaagaagac agctgttcta tttaaatatg ctttggttta 1108201 tgacgaacct tttggatcgg aaggatcgca tgagcatggg ggcgagcctg gaagtgcggg 1108261 tgccgttcgc cgatcaccgg cttgtggaat atgtttggaa tattccgtgg gaaatgaaaa 1108321 tgcatgataa tcgggaaaaa ggcattttgc gcaaagcgct tgagggcatt ttgcctgatg 1108381 acattttgta tcgcaaaaaa agcccatatc cgaaaacaca tcatccggaa tatacaaaag 1108441 gcgtcagcga gtggctgaaa acgatcagaa gccaaaagga ctccgtgctc cataccttac 1108501 tggacagaaa acaattagat cagcttttag aaacggaagg ctcctccttc aaggtcccgt 1108561 ggttcgggca gctcatgaag gggcctcagc tgatcgccca tcttgctcaa attcatacat 1108621 ggtttgaagc gtatcgcatt gatattgacg agaggtaggt tcaatacaaa tgtgattaaa 1108681 agccagagat gtatagattt aaataagaag gatagatgag cagggaaata tatgctctat 1108741 ctatcctttt ttgtacaaca gcactatcga attgcccccg cattccttca ataagaatga 1108801 ataggtttta atgttctgcc gataaaacta gctgataccg ggcttaactt taattcccta 1108861 gcccatacag aaagttgacc aatatggtga atttcgtgag cgatgatatg gtgtaatatt 1108921 tcatctcgcg tatataaaac acctgtctcc caaggaacgc ttacaagttc atcttttatt 1108981 tgatctgaat gtgtttgtaa aacatcaatt atttcagttc ggaatgtatt tgagagagat 1109041 ttcactttat tgagtgtttg ataatcagcg aactgaacag cgatatcttc ttttccttgg 1109101 atagcacgaa tccaactata ttccacatca ataatatgaa aaagggtata taaaatattc 1109161 tctactccgc caagacgatt tttaagtaat tcttcagtgg ttagttgatg acaccaagta 1109221 aaccattgat ctctaacctg ccagttatat tcaaaaaatt tcatcactaa actcactcca 1109281 atactatcat gtatcataac aattagccct tttttccgtg attcctctat taatgaagtg 1109341 atgattgaga aatgtttaca ttctacctgt tgtatggcat taaaaataat aatgcatatc 1109401 tcgtcgatga tgctgtgcgt cttgttactt ttacaaagta agaatcggca ttttcttcat 1109461 atacaattag gaaaaaacat actagacttg aagaagcagt gatacatagg agtgagaaaa 1109521 tgaaagagat aaaagaagct taccagcaat gcggacagat tgttggcgaa tacgcgccag 1109581 cctgtttcaa agcattatca tatctcccgc taaagcaaag acaagcctct tgggcagtat 1109641 tgtcgttttg ccacacggcg gccagtgcag acgaaaaggt attgcccgca tttgaagcta 1109701 aagctgatca tgtttaccaa aggacaaata acggtaaaca acatctatgg aaggcttttg 1109761 atcatgcgta tcggaccttt acattggaaa gcgaaccttt tcgggagttt attgccgcac 1109821 aaaaagaaga cgccaagccg tatgatgacc ttgatgaact gctcatgtac gcatatcgga 1109881 cgggcggtgc tgccggattg atgctgctgc cgatactgac acgccgaaaa caagatcagc 1109941 tcaaacaagc agccgtctct ctcggcttgg ccatacagct ggttcgcttc ttaagtgatc 1110001 ttggcacaga tcagcaaaaa aaccgcattc cccgtcaggt aatgcagcaa ttcggctata 1110061 cagaggctga tctccaaaaa ggcaccgtaa ataaagcgtt cacaatgacg tgggagtata 1110121 tcgcttttga agcagaagcc taccttgaag agtgtcagga tgccttgccg ctatttccgc 1110181 agtattctca aaaaacggtg aaagccgctc ttcatttgca ccgggctgtt ttagaaaaaa 1110241 tccgggcgaa gcagcacgat gtatttcaat atcacttcgc tctcacagag accgaagtga 1110301 agcagattct gtctgatatc taaaaaacac ccggccttga ttgagccggg tgttacgcca 1110361 tacctttttg aatccagata cgtgagcgcc atcttctgta cattaagatt ccccggaccc 1110421 attcatccgc gataaaagaa atccaaatgc cggcaagacc gaaaccgagg tggatgccga 1110481 aaagataagc aagcgggagg ccaatgcccc acattgaaat cattgccatg taaaccggga 1110541 atttcgcatc ccccgcggcc cgcagagagt taatgataat gacattaaac gagcggcctg 1110601 gttcaaggat aatggtcatg gcaatcaata ggcttgcagt tgctataatg tcagggcttt 1110661 gtgtgaagag tccgatcagg tcttttgaaa agatcgtcat caaaacagag gtagccgcag 1110721 caattccgag tgcccaatat aagctcttca tgcagcgctc ataagcggca tcaaattgtt 1110781 tgccgccgat ataacggccg attaagattt gtgtaccctg gctgatcgca gtgccgaaca 1110841 gcaaaataaa catcgtaata ttttgcgtat acacttttgt tgtcaacgcc tgcgcgccca 1110901 tgatggcgat aaaatacgtg actatcattt gcgacaggtt gtatgaaagc tgctctcccg 1110961 cagaaggaat gccgattttc agcagcttgc gcaaatgctc tttatgcata tgaaagactt 1111021 ttttcagcga catcttcagc tggatgcgtt tgttgacaat cacaatcatc gcgattaatc 1111081 cgatgacgcg ggcgatagat gtggacatgg ccacaccggc aacaccgaga acaggaaagc 1111141 cgaacaaacc gaaaatcaca acaaagtttc cggcaatgtt taaaatgttc atgccgatag 1111201 tgacaaacat tgtatctttt gtgtagccgt agctttttaa gatcgcgctg aatgtcatga 1111261 ttaaagcctg aataaaggac agacctccga caacttgtaa aaagactttc gcatcaggca 1111321 tcagtgcgtc tgataatccc atcatatgaa gcagagggac agccgcgaaa aagacgacgg 1111381 cgctgatggc caggctgatg aagaagttgg cgccgattga cacataagcg acttccatgg 1111441 cttctttctt ttgccgtgag cctagaaatt gtgaaatgat aacggtcgtt cctgttgcga 1111501 taaagctgaa catcacgata attaaattta aaatctggtt gctgacgccg actgctgcca 1111561 cgctgttatc cgagtattgg ctgagcatca gtgtatcggc attacccata aacatatata 1111621 atgagacctc aataaagatc ggccaagtaa gcgaaaataa tgagaacgtt ttgtcagcgg 1111681 gttttttcaa agcagttgat ttgaagacag cttgtttcat cgtgtctaac ccctttcgta 1111741 aataaaatca acgttttaaa gtgtacctcc atttccttat aataaaaagg gatagaaacg 1111801 atacttcttg taaaaatccg acttaaaaag gaggatgatt caaatgcctc gcatcctgtt 1111861 tacagtcccg ccttttccgg tatttatcgc agctggggaa ggggttttta aaaaaggaga 1111921 aacccatgtg aaacgtgtat tctccgtgtt tgatctgata tatgtcaaac agggaacgtt 1111981 atatataacg gaaaatgaaa catcgttttc tgttgaaggc ggcgagtaca tcttgctttc 1112041 tcccggtctt gaacactacg ggacgaaggg cagtgatgaa gcaacctcct actattggct 1112101 tcacttcgat gaacatcgat atgaatttac ggcaaaggga ggcagcaact ggtctgagct 1112161 tcagcaggaa aaagggagct tcgaagagct ggcccgctac ggattggcct tgccgagaaa 1112221 aggcaaggtg cagcgcccgc agtttatggc gcagcagttt gaaaagctga tcgattactc 1112281 cgcggaaaac tctgatttgc cgctcagaaa gcaaatttta tttgaggagc tgatgctgca 1112341 tcttcaaaaa gaagcgttcc aaataccgtc tgcgaaagag cgggtagcct gggaggcggc 1112401 ccggtattta caggagcact ataaggaaaa gacgacaatc aaggatctgt cgctcgccct 1112461 tcactatcat caggattatg tgagccgctg catgcagcag gtgctcggcg taactccggc 1112521 acaatacacg aaccgggtga gaatgacgga agcgaagcgt cttttatcct ctacaaatga 1112581 taaaatgggc gttattgcgg aaacggtcgg aatggaagat ccgacatact tttcaaaact 1112641 ctttaagcag atagaaggca tttcaccaat tgaataccgg aaaattgtca gccggaaagt 1112701 tcaataacca gacgagggat gaacatgaaa acaacaattt acgatgtggc aaaggcggcg 1112761 ggtgtttcga tcacaactgt gtcccgtgtg ataaacaata cggggagaat cagcgataaa 1112821 acacggcaga aggtcatgaa tgtcatgaat gaaatggcat acacgcccaa tgtccacgcc 1112881 gcggcgttaa cgggaaaacg aacgaatatg atcgctctcg tggcgcctga tatttcaaat 1112941 ccgttttacg gcgaactggc caaaagcatt gaggaaagag cggatgagct cggttttcaa 1113001 atgttgattt gcagcaccga ttacgatccg aaaaaagaaa caaagtattt ttctgtgctg 1113061 aaacagaaaa aggtggatgg cattattttt gcaacaggga ttgaaagcca tgacagtatg 1113121 tctgctttgg aggaaatcgc cagtgaacaa attccgattg ccatgatttc tcaggataag 1113181 ccgcttcttc cgatggatat tgttgtgata gacgacgttc gtggcggata tgaggctgcc 1113241 aagcatcttc tgtcactcgg ccacacgaac atcgcctgca ttatcggaga cgggtcaacg 1113301 acaggcgaaa aaaatagaat caaaggcttc cgtcaggcga tggaggaagc gggcgtgccc 1113361 attgatgaat cacttatcat ccagacgcgg ttttccttgg aaagcggcaa ggaagaagcg 1113421 ggaaaattgc tcgacagaaa tgctccgact gctatttttg ccttcaacga cgtattggct 1113481 tgtgccgcca tacaagctgc gagaataaga ggcataaaag tgccggatga tctttctatc 1113541 attggttttg ataatacgat actcgcagaa atggcggctc cgcccctgac aaccgtagcc 1113601 cagccgataa aagagatggg gcggagcgtc atcgaactgc tggcagaagc aatagaggga 1113661 aaacgaaagg cgaaacaaaa aatagtgctc ccgcctgagc ttgtagtcag acattctaca 1113721 tcaccgctca acacatgagc ccgctaatga gcgggttttt tcattatgac agttgaagcc 1113781 aaaaaaacat attgcgtgta aaccaaaggc ggtgtaaaat ataaccatct tttgagaaag 1113841 cgcttgcgca aaatggcaga gcggatagaa ccgctgtttt tttagctgtt aagagaaaac 1113901 gctttctcaa agcgagcccg aaatgagata aaggagagga tgggacgtgg aacatcaagt 1113961 aagatgtgca gtattgggat taggaaggct cggttattat catgcgaaaa atctcgtcac 1114021 cagtgtgccg ggggcaaagc tggtttgtgt cggtgatccg ttaaaaggga gagcggagca 1114081 ggttgccaga gaactcggta tcgaaaaatg gtcagaggac ccgtatgaag tgttagaaga 1114141 tcccggcatt gatgctgtca ttatcgtaac gccgacaagc acacatggtg atatgatcat 1114201 caaagcagcc gagaacggca aacagatctt tgttgaaaaa ccgctgacat taagccttga 1114261 ggaatcaaaa gcagcttctg aaaaagttaa ggagacaggt gtcatctgcc aagtcggctt 1114321 tatgagacgg ttcgatcccg catacgcaga tgccaaacgg cggatcgacg ctggagaaat 1114381 cggcaaacct atctattata aaggctttac gcgcgaccaa ggcgcgcctc ccgcagaatt 1114441 tatcaaacac agcggtggaa tttttatcga ctgttccatc catgactatg atattgcccg 1114501 ttatttgcta ggggcggaaa tcacttctgt ttcaggacac ggcaggattc tgaacaatcc 1114561 gtttatggag cagtatggcg atgtggatca ggcgctgacg tatattgaat ttgactcggg 1114621 cgcagcgggg gacgtcgagg caagcagaac ctctccatac ggacatgaca tccgggcgga 1114681 ggtgatcggg acagagggca gtattttcat agggacattg agacatcaac atgtgaccat 1114741 cctatcggct aaagggagca gttttgatat cattccagac tttcaaactc gttttcatga 1114801 agcctactgc ttggagcttc agcatttcgc cgagtgtgtc cggaatggaa aaacaccgat 1114861 tgtgactgat attgatgcga cgatcaattt agaagtgggt atcgccgcaa ccaattcctt 1114921 tcgaaacggc atgccggtac agctagatgt gaagcgcgct tatacaggta tgtaaaagct 1114981 aagtatgttg catttgaggc tttccgcaaa aaaagcaagg gcattttagc ccttgctttc 1115041 tcttttctca tataaatagt acatataatc agtaggtacg cctgaatggt ccagctgtct 1115101 cagcatggcg gttacgttcc ctctgtggta agtgccgtga ttgacgacat gcaggatggt 1115161 gtctgcatag gttgattcca gtgtacctag tttcggatgc tgcattgtga aggtctgttc 1115221 taagtccgtc tggcggctga agaaatcatg atactgtgac tccagctcgg cagcgtgctg 1115281 tttaatcgct gccatattac cttgcgcgga ctgtaatttg cctgcgctgt ctataatctc 1115341 ttggtaggcc actcccgaaa gaacattcag ccaaatgtag tcagccctgc acatatgaag 1115401 cagcacgtcg ctgacagaag gaaatacgct ctttacttct tgataggcag tttcctccgg 1115461 caggttttcg atatgggtaa atattttctt gtttgcccaa gaatgatagt cataaaactg 1115521 ttttgcatca gtcatcagca tgcccccttt tctaagaaat tcgttttttt catctgtttc 1115581 tccttcaatt gcaaaagagt gacaccccaa aatatcctgc cgctgcccac attaccgctg 1115641 cagagcattt gtttacgatc agcataagcc tgccgctcgt atctatcgtc tgaaacaacc 1115701 ggcccgctat tgcaaggctg atgaaccaaa tccaagacac agcgatgcag gcggccataa 1115761 agagccattt ctcaagcccc gaatattgaa gagagctcgt gccgatgacg ccgatcgtgt 1115821 ccagaatggc atgcgggttt aaaagagaaa cagcggccgc aaacgcagct tgcttttttg 1115881 gtgtgaacgt atgtttctca ttttggcttg tgttcggacg gatgttccaa gtcacccagc 1115941 ccatataaag caaaaataaa aatccgccgg ccatcatgac tgtctcaaac acaggcagct 1116001 cctgcacaat gacagacacg cccgcaacgg ctaatacaat taacaaggta tcgcagactg 1116061 aagcactgat gacagctggg agagcccgcc aaatatgctt ttgcaacgcg ccttgctgaa 1116121 aaataaacac attctgcact cccagcggca aaattaagcc aaacgcgagc acaattccgt 1116181 gaatgattgc attcatgctg aaaaagctcc tttcacattt tttttcaatc ataagagaga 1116241 ttgtcactaa agtctccagc catttggttg ggttaggaac cagccaaatg tataatgtgt 1116301 aaaaaagggg ggcatgacct tgtcgcaatg gcagccaagc cgaaagtcgg atgttccgct 1116361 gcatcggcag atcgaacaat atatgaaaga caagattctt cacggagagt gggctgtagg 1116421 gacgaaaatc ccctcacaga gaacgctggc cgacatgttt caagtcaacc gcagcacagt 1116481 cacagcagcc atagatgaac tcacgtctca aggcttgtta gagggaagaa aaggcggcgg 1116541 tacgaaggtt gtaaacagta cttggagcgt gctgacggct gagcctccgc ttgattggag 1116601 cgattacgtc cgttcgggca ttcatcgcgc caattcttcc atcattcaag ctattaatca 1116661 gaacgaacca agagcggata tcatcagatt aggaactgga gaactttcac cggatcttgt 1116721 gcctgctgac acaattggac ggatgtttca gcaaatcaat ccgggcgtcc tgtctttagg 1116781 atatgagcag ccgaaaggaa accgtcagct gcgggaggca gtggccgacc atttaaaagg 1116841 aaagaagatc catgtgtcac cgtctgcaat tttaattgtg tccggtgcac ttcaggcact 1116901 tcagctcatc tcaattggac ttttaaaacg agattctgtc attttgacgg agaagccgtc 1116961 ctaccttcaa tccttgcatg tatttcaatc agctgggatg cggcttcgcg gcttgccgat 1117021 ggatgatgaa ggggtcaaag cggggcttgt ttcttctaat cgaaaacaat atggaggaca 1117081 gctgctttac acgattccgt cgtttcataa tccgacaggc acagtcatgt cagagcagcg 1117141 aaggaaagag atcatcagcc tgtcaaaaaa agagcagatg cccatcattg aggatgatgc 1117201 gtacggtgat ttatggtttg aagaaaaacc gccgcagccg ttgaaagcaa tggatcatga 1117261 gggcaatatt ctgtatctgg gcgcgttttc aaaaacggtt agccccggtc tgcgaatcgg 1117321 ctggcttgcc ggtccggagc cggttattga aaggctggcg gacattaaaa tgcagacaga 1117381 ctacggatca agcggcctgt cccagtgggc ggctgccgag tggctgtcac agggatatta 1117441 tgaagagcat ctgacttggg tacgcaggaa gcttaaagaa aggagagacg ccgccgttca 1117501 ttttctcgag cggtatgccg gggacattgc cacgtggcgg attcccgcag gcggctttta 1117561 tatttgggtg acatttcaca aaaacctgcc tgtcagccgt ttcttttatg aattgctgaa 1117621 acggcaggtg cttgtgaatc ccggctatat ttatgacggt gaagaccgaa acagcatcag 1117681 gctgtcatat tcctatgcat ctcttggaga tttggaaact ggcattaaag cggcagctga 1117741 aacagcacgc cgcctgatga tgtcctaggc tttggttata cgatgacagc tcccagtgcc 1117801 ctggcgaagg caatcgcgtg ctcaggtgcg attttgcagc ctttcaattt gtcgagggag 1117861 acatgaagct gttcaaaacg gcacgtgctg atgtccatgt tttgaaggga cgtgccggta 1117921 aagctggcgc cttccaattc gcatccgtca aagtgtgtct gctggagcac cgtatcgctg 1117981 cattcacttt gcataagagc acagtgatca aatcgaactt gtttcatatt tgagtacgaa 1118041 aatgagctga aatgtccgtg gcattcctcg aatgaaacat tccgcagcgt tgcttccgcc 1118101 acattcattc caaccatttt tgactgctta actgaagttc tgtgaatgac agccccgctg 1118161 aaatcggcgt ttgataaatc gcatttttca aagatcacat cggtcagttc aatatgccga 1118221 aaagacacat cgataaagac gacatttctg aataccgttt tttcaacaca tagtctttcg 1118281 atatcttcgc cgcagatggt gcaatcttca aacaaatgca tgctgattac atcatcctgt 1118341 gtcacggcat catgaaaatc tgcggtttgc aggttttccg gtatgttcgg tttttgaatt 1118401 gcgattttat tcatgtgatg acatcctttg ctgcccgaaa aacagaggct tccgggttca 1118461 atttaataga tcgttaagga aattgataca tatagtaaat cgtgaagagc cttttcttgg 1118521 tacagcagcc cgcttgtttt gtaagcataa atggaaagct tcctatacgt caaggcgttt 1118581 acaggccgaa aaagccaaag ggaacaggag gaatgcggaa tggggcatta catcaaaacc 1118641 gaggagcatg tgacactgtt tgtagaggat atcggacatg gaaggccgat catctttttg 1118701 cacgggtggc cgttgaatca taagatgttt gaatatcaaa tgaatgagct tccgaaaagg 1118761 ggatttcgtt ttatcggcgt tgatttgcgg ggatatgggc aatctgaccg cccttgggaa 1118821 ggctacgatt atgacacgat ggccgatgat gtgaaagcag tcatttatac gctgcagctt 1118881 gagaatgcga ttcttgccgg tttttcaatg ggcggcgcaa ttgcaatccg ttatatggca 1118941 aggcatgaag gagccgatgt tgataagctg attttactgt ctgcggcggc ccccgcgttt 1119001 acaaaacgcc cgggttatcc gtacgggatg aggaagcagg atattgacga tatgattgaa 1119061 ttgttcaaag ctgatcggcc caaaacactg gctgatttag ggaaacagtt ttttgagaaa 1119121 aaagtgtctc cagagcttag gcagtggttt ctcaatctga tgctggaggc ttcctcctac 1119181 gggacgatcc actcgggcat cgcattaaga gacgaagatc tcagaaagga acttgctgca 1119241 atcaaggtgc cgacgctgat cctgcacggg agaaaggata gaattgcgcc gtttgatttt 1119301 gcgaaagaat tgaagcgcgg catcaaacag tcggaattgg ttccgtttgc aaacagcggg 1119361 cacggagcat tttatgagga aaaagagaag atcaacagtt tgattgcgca gttctccaac 1119421 tcataagaaa aaacccgaca ttgatcgggt tttttatata attcctctgt tttgcagtgc 1119481 gttaatgatg agatcagctc catcggaaat agaggtctgg tcagactcaa tgatgaaatc 1119541 gggtgaaagc ggcgcttcat acggagaatc gatcccggtg aaatgtttga tctctccgtt 1119601 tcgcgctttt ttataaagcc cttttggatc gcgctgttca caaacatgca gcgggcactt 1119661 cacataaatt tcgaagaact cacctttagg aaagagcgct ctaaccatgt cccgatcctc 1119721 tctgaatgga gaaataaaag ccgttaaaat catttgcccg ctgtcgacaa acagcttcgc 1119781 cacttctccg atccggcgga tgttttcaat cctgtcacca gtctgaaatc caagatcttt 1119841 gtttaagccg tggcggatat tatcaccgtc aagcacgtag ctctgaatgc ccttgcggta 1119901 aagcttttca tcgacagcat tggccagcac cgattttccg gagccggaca aacctgtaaa 1119961 ccaaaggacg cagcttttgt gtccgtttaa ggactgtctg tcagactttg agatggcagc 1120021 gggatgccaa atgatgttcg gattgtgtgt cattgcaatt ccccgctgtt ttgcttgatg 1120081 gcaacaggct gttggtgaag tcccttgatc agcacggctg cgacctcagg ccggctgaat 1120141 tctttaggcg gctttttgcc ttggcggaga agctctctca cttttgtgcc tgataagtgg 1120201 atgtggtctc tcgggctgtg cggacatgtt ttggaggtgc ccatgtttcc gcattttcgg 1120261 caataaaagc tgtgctcaaa aaacagcggc ttgatgccca gctcttcctc tgtgaatgat 1120321 tgaaaaatat tttgggcgtc gtatgttcca tagtagctgc cgacacccgc gtgatcacgg 1120381 cctacaataa aatgggtaca gccgtaattt tttcggacga gcgcatggaa aatcgcttcc 1120441 cgcggacctg cataacgcat ggcggcaggg aaaaccgata acatgacacg atcctttgga 1120501 taatagtgat taagcaaagc ctggtagctc tccattctga tatcgctggg gatatcgtct 1120561 gactttgttt ctccgacaag tgggtgaagc agcagaccgt cgaccgtttc taacgctgtt 1120621 ttttgaatgt attcatgcgc tctgtgaaca gggttcctgg tttgaaagcc gacaatcgtc 1120681 ttccagccga gtttttgaaa ggccgctctt gtttcagcgg gcgttgcata aaactgttcg 1120741 aaagatttgt caggcaggct gctgaccgtg ataggccctc cgatatagta atccgggcgc 1120801 gccagcaatt tttttacgcc tgggtgggca ggatcgtttg ttttaaaaac agacagtgct 1120861 tcttgtgttt tatcaggctg gtatatatcg gtgactgtga tcatgccgta ggtaacaccg 1120921 tctttcacaa gcttgacgtg atctccggca gacagctgtc ttgctgtttt ttctccgaca 1120981 ggcagcgtaa tcggcaggct ccacggcaag ccgtttgcca gcctcatctc tttcacaacg 1121041 gaatgataat ctttttctcc caaaaaacct gttaacgggc tgtagccgcc gatcgcaata 1121101 agctccagat cactcagtgc aagctgatcc agctctgctt ggcacgcgca cccttcaaaa 1121161 tggcatgcgg gatcacagcg gttgattaat acccctccgt ggggttcgtt tccattcaac 1121221 gtgttcaacc tccatttata cgtttccttg ttttcttttc tgcacttaat gaaagtttga 1121281 catcagcgcc ttaacatcat ttcgattctc acatcaagaa cctgccatcc gctattcttg 1121341 atgcaggccg cattctgttt tctcccgtcc ggcccatctt ccagccctct catcgttcgg 1121401 gtccggggaa ggcagtgtac acatttcaca gcctatgctc ggataatgtt gatcgtgcag 1121461 tttgttataa ggcaaattgt gcaggcggat gtacgtccaa acgtcatccc atgtccagtg 1121521 gataagcggg caaattttga tgagctcaaa cttctggtcc aggtttacgt attgaatatg 1121581 ctttctcgtt ggtgactgat cccggcgcag tcctgaaatc caagctgtca tgccggacag 1121641 gtgctttttg agcggttcga ttttccgcaa ttggcagcag aggttcgggt tatgcttcca 1121701 cagctctccg ccgtacttcg tcccctgttc tgttaagctc agctcgggtt cgagcatctg 1121761 gattgcaaat cccggatatc gttctttgac ggtctcgatc agctcatatg tttcctgaaa 1121821 atgaagcccg gtatccaaaa agatgatgtg tgcgtttttg ttgatttttg atattaagtc 1121881 gagaagcacc attccttctg cgccaaagct gcaggcgtac acaatctttt ctccgtacgt 1121941 tcggtaagcc catttcaaca catcgagctc atcgatcaat tgatccgtta tctgtttgga 1122001 cagcatgtcg ttccaagtgt catatgtgat ggtttcgttc aatgttttcc ccccgtttgc 1122061 atctgctttt tttatctatt gatcgagtta taggcagact attcattttt tgcataaagg 1122121 ttcaggtttt aggtgccgcg cccgcctaaa atgaggtgcg gaaccattaa gagcccggct 1122181 gaatatgctt tttagcaaaa tggttttatg cccaaggaga ggtagtatgc cgattgccat 1122241 ttatcagggg catcatcatt cgcttgcccc ggcggacatt aacatcgtca ttgatgtcat 1122301 cagagccttt acggtcgccc attatgcgtt tatcggcggg gcgaaagaga ttttgttggt 1122361 ccggacagct gatgaagcct ttgcgctgaa agacacctat ccggattatg ttttgacggg 1122421 agaggaaaag ggggtcggta tcagcggatt tgatttagat aattctccaa aacgtatggc 1122481 tgggcagaat atgacggata aaagcctgat ccagaaaaca acaaacggcg tcacagcagc 1122541 attgggggcg ctgaacgcaa agcatctgtt cgtaactgga ttttccaatg ccaaaacaac 1122601 ggcacagcat gtgaaaaagc tcgtcgcaaa cgattgtgtc ataaacatag tggcttccca 1122661 tccatccggt gatgacgata tggcatgtgc ggagtatatc aaaggcatca ttgaagggac 1122721 aaatgtggta acggctgcgg aggcgattga aagaataaaa ggctcttctg ttgcggagaa 1122781 gttttttgac tgccgccagc cattgtttga ttcggaagac atcgtttact gtacaaaaga 1122841 actgacgggc gatttcgtga tgaaagtgaa acaagatgga gaagttccaa cgatagagag 1122901 ggtcataata tgaatgattt ttcactagaa ttgccagtga gaacaaacaa gccgagagaa 1122961 accgggcagt ccattttaat tgataacggc tatcccttgc aatttttcaa agatgcgata 1123021 gccggagcgt ccgactatat tgattttgtg aaattcggct ggggcacatc attacttacg 1123081 aaagatcttg aagaaaaaat cagcacactg aaagaacatg acattacatt tttctttggc 1123141 ggcacactgt ttgaaaagta cgtaagccag aaaaaagtga atgaatttca tcggtactgc 1123201 acctatttcg gctgtgaata tattgagatt tcaaacggta cgctcccgat gacaaataaa 1123261 gagaaagcgg cttacattgc cgatttttct gatgaatttc ttgtgctcag tgaggtgggc 1123321 agcaaggatg cggaattagc aagccggcaa agctctgagg aatggcttga atatatcgtt 1123381 gaggatatgg aagcgggcgc ggaaaaagtg attacagaag ccagagaaag cggaacggga 1123441 gggatctgtt ccagcagcgg cgatgtcagg tttcaaattg ttgacgacat catttcctcg 1123501 gatattgata tcaacaggct gatttttgaa gcgcctaaca aaacgcttca gcaagggttt 1123561 attcaaaaaa tcgggccgaa tgtgaatctt gccaatattc catttcatga tgccatcgcg 1123621 ttggaaacgc tgcgtttagg gctaagatcc gatacctttt ttctgtaaaa tagcggctgc 1123681 ggggctctcg tcgtgaagag agcctctgcc tattattttt tatggcggta cataggcgtg 1123741 agatagggaa gtgaggtcag gcggatgttg tagatgaagt cgatgactct tgtcgatatc 1123801 acctggcata tgagggcttg aatgacgatg ccccagtcaa taatagacgc ggtgaccata 1123861 aaaatgatgc aattcatgat gagcaggatc gttccaggat tcccgccgcg gtagatagaa 1123921 atcatcagag caagggctcc gaatcctccg ttcgaaattt tatatttgta taaaagtccg 1123981 attccgagtc ccaataacac tgcgccgctt gccagatcaa gccacaggtt agatgtgata 1124041 tcaggaaaaa ctgcatcaaa gatcaatacc gagacagagg tgacggtgat agaagcgagg 1124101 gtgccggtga atgttctcat ctccagccat tttaaagcgg taaaaagcat tgatacattc 1124161 acagcccaca ctgaaaatcc gtgggggatt tgaaacagat aatgcaatag caccgcaata 1124221 cctgctgcac cgcctgtcgg aatatcatgc ggaaataaaa acaaggacat gccgagtcct 1124281 tgtagtacgc cgcctacgac aatcataaac gtaagttttg ctttcatcag cagttcagcc 1124341 attaagtcat ttgctccttt atgaaaagac ttgtccgctg ttttcatttt atgaggctgt 1124401 ccattattta tgtctcaaaa taaagaaatg gcccagctta ataggctgag ccatcccact 1124461 tgtagcgatt gacgatctcc atattgatct ctgtgccaat gccttttcct ttcgggatgt 1124521 ggaccattcc ttttgaaggc tgcaggctga cgagatctgt aaaaggattc tccatgacgt 1124581 cccactcgat cggttcaatg tgatcgttct tcattttaga ccatgggggc agacaggctt 1124641 gtgcaaataa agcatagagc cgtgagagcg atccgtcata tgcatgggcg gatgctctga 1124701 cgccgaaata acgcgcgagc tggaggcagt cccgaaactc atcaattccg ttgacatgca 1124761 tgacatcggg ctgaatgata tccaaacagc gctgtgaaag gagaggcaca tattgcgccg 1124821 ggcctttcat gttttctccg ccggcaacag gaacagacaa acggcttcga agcatagcgt 1124881 aatcctgcgg ctgatcaaag ggcaaaggct cctcaagcca gccaatgttc gtccattcgg 1124941 agaaatagcg ctcccattta aaagccgcag cggcatcgta gctttggttt gcgtccagaa 1125001 tcatcgtaat ggagctgcct gctgtatgct gcagcgcatt gatgtgccgg acatcctcct 1125061 tgaatgaagt cccgccaatt ttgactttga tttgctcaaa accttttttc aactgggctt 1125121 caacattgga gactgagcgg ctgatccatt gcggggagtc tgagtacgat tgaaaagacg 1125181 cgtacacagg aatctcctct ctgtatcgcc cgccccataa ttcgcaaacc gaacaatccg 1125241 cagctttggc tgcaatctct gtcagcgcca tgcttacagc ggaggccgcc cgctggtgcc 1125301 atttttgaat cgtgcgcact aatgacaggc ggctgccagc ctgttttcct aatagaaatg 1125361 ggatgatccg cttcgtaaaa ccgacatgga gagcagggag ccaatcaacg cattctcccc 1125421 agccgtctat cccgctttcg gtgataatcc tgatgagata acaagtccga tatcgtttaa 1125481 acccattggc atctccgtat ggcttttcta atcgatgaaa tagcggaaag gtttcaatcc 1125541 gtacaatttt cacactgggt gctacctttc ctcagcgggc tggagccgat tgccagccat 1125601 tttagggtct tctttttctt ttgtttcttc attgttttgc ttcacatgga tgagcatcat 1125661 cacaagaatc ccgacaacga gagtcaatcc cgcgatgctt aaaaacatgc cgggtctgga 1125721 ccattgcatc aggcggccga aaatcggagg accgatcgct acccctaaga aacgtacaga 1125781 gccgtacagc gaggtgacaa atccccgtct ttctttgccg acagccccgg taatgaaact 1125841 gttcacacaa ggaaggacaa gacctgagcc tatactgctc agtacaagaa cactgataaa 1125901 aaggacaaga ttttcaatga atgacagtgc cgcgtaggat acggtcatga acgccaatcc 1125961 aagtacgatc agctttttca ttaacgattg cttttgcccg attttgcttc ctgttgtata 1126021 ggacgtcaca cacataacca aaagcgggat cgctaaaatt aagccttttt tcacgccgtc 1126081 ggtgtcgtat gttttttcaa gaacatctga gagataaaac aggatgccga ataaagtaaa 1126141 caaacaggtc gcaccggcta aataagcggt aaacagccat ctgccttcat gtttaaagac 1126201 acttaacagc ccttttgcat attgtccgat tggtggcggt tctttttcct ttttcttttc 1126261 tttaataaaa atccaagtca gtacgatcga aatgatacaa aacacaggaa aggcaaaaaa 1126321 cgcgccatac cagacaagca gggcgatcag cgagccaatg atcggcgata gcactttccc 1126381 catgccgttt gaagcttcaa caaggccgag caccttgctc tcctgggcgc ctttaaacag 1126441 atctcccgtc agtgccatgg caattgggcc ggttccggct gccccgattc cctgtaacgc 1126501 tcgtcctgcc atgacccaag gataggcatt gtcaaaaaaa cctgccgcaa acccggctaa 1126561 caaaccgccg gcaccataca aaattaagca gggaataatg atgactttcc ttgagaatcg 1126621 gtctgcgaga taaccgacaa tcggaatcgc aaatgctgca atcaaggaaa atactgtgat 1126681 cacgagactg acttgaaatt gtgataaatg aagttcagat ttcatttttg gcaaaatcgg 1126741 aataagcatc gagtttccta gggttaatat taaagggatt gaaccgattg ccacaatcgt 1126801 cattccgtta ttttgttttg atgattccat ctcagagcac actccttttc ttctgcttag 1126861 aatgtccctg atggcttcgt ttattcagcg atcagacagc aaaaaaccga acagaagata 1126921 cctgttcggg aaaaaagagg gttaaccgag agcctgtgaa atcaaagcat ataagtgtcc 1126981 attttgaata ggcgcttttt tctgatagaa caaaatcgga ggttcatcat ctttatgaaa 1127041 tcccatttct atcaggctgt catgcagaga cgtgtgttca ctcggtatat cgattcgcat 1127101 cggcccttgt ttgccggccg ccagccttgt aattatctgt gctgcaacat ctgatgatgg 1127161 agcgatgata gggccgaatt tcaaattggc cggtgtctgt acagaaagtc cgtagccaat 1127221 gagctgtccg tcctgatttc tggcgatgat acattcgcat gaagcagaaa taagctgctg 1127281 caaaaggttt gatcgatctc cgccaaaggc agccagatcc gccgcggtta agtcgtgaaa 1127341 gtcttgttct ctaaaggatg tcagttcagc atcaagcttt tttgtataag gttgaaaact 1127401 gtgacagctg tactttcgca ctgaacctgc cgtatgaaaa cctgcttttt cataaagcgg 1127461 caaaccttct tttgtggcgc aaagcctgat ggcggtgttt tcatccgttt gggtaataca 1127521 ggcgtttacc atacgccggc caagaccgag ccgttgatat tccttgtcaa cgataacaag 1127581 gccgatagaa gtaagacggc caaacaaaaa caagccgatg caggaaataa tatcaccgct 1127641 gacattttga taaccgaaaa agcgtccctg ctgaacaagc agtttcagct cttgttcgcc 1127701 ataatccggc cacccggctt gcccgcaaag ccgcaataag ccggaaacgt gttcttcatg 1127761 aagcttaatc agttcatcta ctacgtccat aagatcacct gcttgttcta agtgttttgt 1127821 acatgacaat atgattgcca atgccgggaa tgtcaaatgg ttcgccaagt tccttccagc 1127881 caagcttggc atagtagccc ttgacatggt gtcttgcgtt gcaccatacc gcctgaacgc 1127941 cgctctccgc cagtttgtgc tccgcgtgtt tgatcagcgt gcttccagct ttttgatcgc 1128001 gatatccctc gagcgttgcc atgcctctca gccgatacgc agaggcttcc gttaataaag 1128061 gctgactttg cggggaaaaa gaagcgatgc tgatcagcgt tccatcataa aacacgccga 1128121 gatgaaagga gccttctgcg tgatcctctt tatatttgca ttgttcgatg gattgatggg 1128181 gacgcagaat gcgatgccgg atttcatatg tatcttccac ggaaatggtt ttgacttcga 1128241 gcataatgtt cctcctcatg attgtttttc tatatcgtaa cacgaatctc gttgaaaaag 1128301 actgcccgat tcgatcaggc agtcttttgg aaattaatgc aaaaagatat tttggcgctg 1128361 ctcatctttt tgctgaatat atgatgtgag ctcagcggtt aagtcagatc tgaggaaagg 1128421 cgttatcaag tagatgccgt taaacagctc gcatgccgta tccagcaggg agcgtgcaat 1128481 tgcaaggcct tccgcctttt gcttttcttt atcttcaccg gcatgggcca ttttttcgcg 1128541 aatcgtatca gacagcttaa tgccgggaat ttcattatgg atgaattcgg cattccggct 1128601 gcttgtcagc ggcatgatgc cgatatagat cggcgtcttc agatgttttg tttcgttatg 1128661 gatatcgaca agctgctgct cggaatagac aggctgagaa acaaaataat ctgcgccgca 1128721 atctattttt ttctcaagcc gttttaccgc tttatccaga tggcggacgt taggattaaa 1128781 tgcggcggca actgagaaat tcgttttctt gccgagcggt tttccagaca gagacagacc 1128841 ttcattgaat tgtttgatca gcctgattaa atcaaaagat gttaaatcat atacagacgt 1128901 cgccccagga aaatccccga ttttagaagg gtcacctgta atagcaagca cgtcattcag 1128961 ccctaacgta tcaaggccca ttaaatgtga ctgtaagccg ataatgttac ggtcacggca 1129021 cgtaatatgg acaagggaac gcatatcgag ctgctgcttg acaagggcgc cgcaggcaac 1129081 attgctgatc cgcggggtcg ccaaagaatt gtcggcgagt gtcagggcat cgattcccgc 1129141 ttcttttaat tcagcagcag cggacagaaa tttgtcaaag cttagttttt tcggcgggtc 1129201 cagctctacg ataatagagc gttttttcgc tgcgatctca tccaggccgg gctcggttcg 1129261 ctcgtgatga acagaaatga attctttcgc ccgggttttg acttcttttt ccgtaatcgg 1129321 agccagcccg ccaaccgctt ccgccatcgc cctgatgtga ttcggcgttg tgccgcagca 1129381 gccgccgata atccgcgcac cttgcttacg gaattctgac gcgctgtttt gaaaatacgt 1129441 gtcgtctgtt tcatagacga gccgtccctc ttcaagcgaa ggaagactgc tgttcggata 1129501 aacggataag aatacgtcat caaaaatcgg cacttcgctt agcgcttcaa tcatgtgata 1129561 agggccgagg cggcagttaa tgccgacaat atcagctccg agatccgcaa tcgagcgcaa 1129621 tgcgtcagaa agcggcgttc cgtcctgcaa tacgccttgc tcgtgcatgg agacattgag 1129681 cataatcgga agatcagtct ctttgcgcgc gattttcagc acttcacggg cttcttccaa 1129741 atcataatat gtttctaaca gcaagccatc cggctcttca tgcagcagca gatacagctg 1129801 ctcgcggaag ctgcgcttaa tttcgtcaag actgtatgcg tttttattaa atgtgcgtat 1129861 gccgcccatc gttccaagca cgtatgcatc gcctgctgaa gcccgcgcga tctttacggc 1129921 ctcctgattc atttttttga tgtcatcctc aagcccgtgt ctggataatt taatatagtt 1129981 ggctccgtac gtattcgttt gaataatgtt ggctcccgct tcaacgtacg ctttatgtat 1130041 gcgctgaatt tcctccggct ttgaaatatt gagctcctca aaacacctgt caatgccata 1130101 ggagtagagg agcgtcccca tggcgccgtc accgattaac acctgtcttt gcaaatcttc 1130161 taaaagtccc attgtctgcc tcctttattc acatcagcaa ggaaaaaaga gaaataaaaa 1130221 aagtcctctt aagaagaaga ctttgtcagt gattttgtct cttcttatct tccaagctgt 1130281 tcgagcttgc tggatttagc accttggtca tggctgatcg ccattacacc ggttgctgaa 1130341 gcttcgtcgg gccagtccct ctgcttctct tgataagaac ggatatgaaa ttttcgtgtc 1130401 aggaagtgcc aaaagatatc tggcgttttt ccctttctcc aaatttaccg aaaataaaga 1130461 caataatcaa taggaatcag aaaatttatc tgaaatttat aaattgaacg tcaattggca 1130521 gatctgctcc ccgtacagct gagataatct gctgcaggtc atctttgttt tttccggtga 1130581 cacgcacttg atcatcctgc acctgagact ttactttcag tccggagttt ttgatgatcg 1130641 tattgatttt ttttgcgttg tccttgtcaa tgccttgaac aagctttgca cgctggcgca 1130701 ccgttccgcc tgacgcgttt tcaaccttgc cgtaatcaat gttttttgtc ggtacgtttc 1130761 gtttaatcaa tttgctgacc agcacatctt tcagctggct taatttgaat tcgtcatcgg 1130821 aaacgaggac cagctcctct ttatctaaag aaatgtcgct tttgctgcct ttaaagtcat 1130881 atcgggtact gatttccttc agtgcgattt ggattgcgtt ttgcacttca ggcaattcca 1130941 ccttggatac aatatcaaat gaactttctt ttgccatatg aaaacctcca taacatttaa 1131001 cttatgtgtt gattatagta gaataaagag aaacttccaa cagaacaaag aatcaatttg 1131061 tgatgattgg aaaaaatgtt aacaaaatcc gcagagaata agcggaacag gaaggacgat 1131121 agcatgagac cagggcagca attaaccttg agtatagatc accaaaccga cttcggttac 1131181 tttttaaccg atggggaaga tacgattctc ttacataaca gtgaaatgac tgaggatatc 1131241 gaggacagag acgaagtaga agtctttata tacgtagacc agcaggaaag gcttgcggcc 1131301 acgatgaaaa ttccgatcat cagcgcggat gaatatggct gggttgaagt ggtggataaa 1131361 gtggaagata tgggcgtttt cgttgatgtc ggtttatcga aggacgcact agtcgcaact 1131421 gagcatttgc cgccgtacga agatgtctgg ccgcaaaaag gggacaaact ttactgtatg 1131481 ctgaaggtga cgaaccgggg gcgcatgttt gcgaaaccag cgccggaaga tatcatcagc 1131541 gaactgttta ccgacgcttc agaagatctg atgaataaag agctgacagg tacggtgtac 1131601 aggctgatcg catcgggttc attcgtgatc acggatgacg gtatccgctg ttttattcac 1131661 ccgtcagaaa gaaaagagga gccaagactg ggttcaagag tcacaggccg ggtgattcaa 1131721 gtgaaagaag acggttcagt caacttgtcg ctgcttccga gaaaacagga tgcaatgtca 1131781 gttgatgctg agtgcattct aacgtatatg agaatgagaa acggtgccat gccgtacagt 1131841 gacaaaagcc agcctgacga tatcagagaa cgttttaata tgagcaaagc cgcctttaaa 1131901 cgcgcgctgg gccatttgat gaaaaacgga aaagtgtatc aggaaaatgg atggacatac 1131961 gagaaaaaat agcatgaaaa cggctcgcct gcagcagact gcggagcgag ccgttttttt 1132021 atgtctagtt taattcatca accagcgttc tgattgccat ttcgcgatcc acattgtctg 1132081 aaatcgcaat cggcgtaata tcaatggcga gaatgatcag aatcagggca cctgctgcag 1132141 caacataaga aacataatag aaatagttag cggtatcaac agtgttgaca agctcggcct 1132201 gaactctgga tgtatcatcc ttagaagcgg cgatttcctt tgcagcttct actttttctt 1132261 caacgatttg acctgctttt ttcagcagtt catccacttt caatgcatct ttgctgtaaa 1132321 cagctttctt caggttatca aaaaagtcag catcctcttt tttaatatca gcgacaacct 1132381 gattggcaaa agcctttgcc tgttttgtgt tgagtttgtc tgtcatcgct ttattaaaga 1132441 cctctggaag ctgtttgcca acttcccctt gggcaaacac aaagccttta aaaatttcct 1132501 cacctgaata ctcaagctgc tttgcctgtg ccacactttc ttgctgcttc accaaaaaca 1132561 cagtcgtcac caatacaacc gacaaaaata ctagaaacgc cttcttcaaa ctgaaacctc 1132621 tcccttcttg tgttttttat tccacaacag tctgcgaata tatgtaaatt gaatcgtgga 1132681 atcgatagga gtgagataca atatcaaaat gccggccatg ataatcgaaa aactgatgag 1132741 gcccagcatg actgcaaaaa tctcatgcat aaaaacagcg atgatcaaaa tcaatctcca 1132801 atgcttcttc ggcgcaaaca gtgccgcgaa gatgacaatt tgaaccagca gcgtccccca 1132861 tgtcggaatc accacgaacg gacttgttac aattggcttc gttaacgcct gaaaaaagcc 1132921 gttgaagcca atggtttttt cctgggcgaa ataatagacg gccgttccgt ccacccattc 1132981 ctgctgagat agcttagcga cggtagagtg aaaataaagc accgccactt ggattctgat 1133041 cacaaaataa gaaataaaag ctgttatttt tccaagtgtt cttttgccct ctataggtct 1133101 cgtactccaa tgccattttc tcggatcggt cagcgtgatg ggaagcaata aaaaggtcat 1133161 gactgctgct gcctgctcgc ctccgtcgat gacgatcagc gatgactgca ggctgtaact 1133221 gacataccaa tgcagaaccc cggtgattct ggggcgccag ccaatgacaa caagcaccag 1133281 aatggcaatg cagacccatc tgaaaagatt taacatcata tagttatttt cgccgagaca 1133341 aaagagactg agattcattt tacaagctgg atagctgctg atcccgctgg ctggcttcat 1133401 aatgaggctc gggtgattga tgagcagcgt cagcaggctg gatagcgcaa tgatgcttcg 1133461 cgcgaggcca tatacatttg tccacgggtt tctttcgtcc catctggtga tggtctgttt 1133521 tatgttttcg agcatgagat cacaaccttg actatgcttt ttacctgata agacgaaggg 1133581 gtatatttag aatagctcca aggaacaata tcctctttcg tcaaatagta gctgccacaa 1133641 agcagcgggc ggggagcggg tgtttttaat tgcacggttt tggctttgct tttgcatgcg 1133701 ccgaggtcct tttctttaca tgctgtccac tgttccttgc cgacttggct gtagatcacg 1133761 cccatttcaa cgccttgtga ccgcccatac cgatacaggc cgaataggtt gtcagccctc 1133821 atattgggcc atctgacctt ggcgctggca ttttcagcct catataagcc gattgcagta 1133881 tcacgcggat ttttgctaaa aaagccccag ccctgaggga ggatgctgga catgagaaat 1133941 ttggagtcct ttgtcagcgg aatcggggtt gtccctaagc tgccaataat agaaaacaga 1134001 aatagcgaac cccaaaggat tgaaaaaatg acaaaaaatg atatcgattt ctgcattcga 1134061 ctgctccttt taacctgaag aatcgttttt acacttttca taatataaaa acatttatgt 1134121 aataaaaagg ttaaaaagta tgagaaattc catttttgtt aaaaggaaaa acaggacatt 1134181 ttacactgct atatgtgatt gatatatagt gtttttttcg atatatttaa accatgaaaa 1134241 cgaatcaagt taatgaccgc tggattgttc aatttcgaaa agggattttc gagctggcca 1134301 tcctatccct tctgcgttct aaaccgatgt acggttatga gctgacgtca tccttaaaaa 1134361 ccacctcggc gctggctatt tcagagggag cgatttatcc gattttgaaa cgtatgaccg 1134421 agaagggatg gatcgaattt ttttgggaag attcactgga cggcccgaaa agaaagtatt 1134481 acaaaatgac gcaaaaagga gaagaaatgt taaaagaacg gctggagaaa tacctggaaa 1134541 cccatcaagc cttactgtct ttatcggggg atttgctatg aatggacagc ttatcattga 1134601 ccgatacatg gaggaactaa atgcagagct ggcgaatatg cctgatgtag agagagaaaa 1134661 cgctatcgac gaattaaagg ggcatatcac cgctttcgtt caagacagaa tcaaagccgg 1134721 ccttagtgaa gaggaactgc aggaagctgt tgaatctgaa ttttctcatc cgaaggagct 1134781 tgccgaattg atgatgggtg atgggggaga gacgaaaagg aggaggtctt tattgggcaa 1134841 aagctggatt tcggtccttc tcattgtcac gattatcgcc ctgccgctgc tgccgtccga 1134901 cttcagacat ctgccgctgg ctgtttattt aatggtgctc gccggatatg tatggaagcg 1134961 gaaaaaattg gtgatgtttg caggtgtcag aaaaaacaaa atgcgctctc aaaaggagat 1135021 tgtcaagatt tcgcgagtcg gtgcggttta tctgctgttt ttagcagtgg tgctcctttt 1135081 gagcccgttc ctcaatgcgc ttgtcgtcct gctgctgatt gcagtaagct gcgccgcttt 1135141 ttttcttttt cttaacatca agtaatcttg taggaggctg taagatggaa atcagcatca 1135201 attatctatt aattgtcatc gcgcttttat tctttgtggt tgcctatttt gtcggaatca 1135261 aaaaacaaac ctggatgttg gctgggttta acgaggcgcg tatacgggat aaagatcggc 1135321 tggccagaat agcaggctac tttttcttga attccggttt gttcattttg ctgaatagtt 1135381 ttatctcatt tcaaggtcag gagcagctca tacctccgct tatactggca tatggagcag 1135441 gggttattat ttatgtcaat aaaaaattag tagagtagaa aaagaagggc agagcgaaat 1135501 atctctgccc ttcttttttg ggaaaataag aacgaagcac cacatacaag tttttgtatt 1135561 tttgatagga tgaagaaaaa tggtagattc caaaatagga aggatgtggt gttttgcgca 1135621 acttgaccaa gacatctcta ttactggccg gcttatgcac agcggcccaa atggtttttg 1135681 taacacatgc ctcagctgaa gaaagcatcg aatacgacca tacgtatcaa accccttcat 1135741 acatcatcga aaagtcaccg cagaagccgg tacaaaacac aacccagaaa gaatcgctat 1135801 tttcctatct tgacaagcat caaacgcagt ttaagctcaa agggaatgcg aacagccatt 1135861 ttcgcgtttc gaaaaccata aaggatccaa agacaaaaca aacgtttttt aaattaacgg 1135921 aggtttacaa aggaattccg atttacggct ttgaacaagc ggtcgcgatg aaggaaaaca 1135981 aacaagtgaa aagtttcttt ggaaaggtgc atccgcaaat caaggacgtc tccgtcacac 1136041 cgtctatttc tgagaaaaaa gcaatacata cagcaaggcg tgagctcgag gcttccattg 1136101 gaaaaatcga atatcttgat ggggaaccaa aaggcgaatt atatatctat ccacacgacg 1136161 gtgaatatga tctcgcctac cttgtgagac tctcgacatc tgaacctgag cctggctatt 1136221 ggcattattt catcgatgcc aaaaacggaa aggtcatcga gtcctttaat gccattcatg 1136281 aagcggcagg tacaggaatc ggcgtgtcag gtgatgaaaa aagctttgac gtcacagaac 1136341 aaaatgggcg cttttatttg gctgacgaaa caaggggaaa agggatcaat acatttgacg 1136401 cgaagaacct gaacgaaacc ttgtttacgc ttttgtctca actgatcggg tatacgggca 1136461 aagaaatagt cagcggcacg tccgtattta atgaacctgc ggctgtagac gcacacgcaa 1136521 atgcgcaagc cgtttacgat tattacagca agacatttgg ccgtgattct tttgatcaaa 1136581 acggagcaag gattacgtct accgtgcatg tcggcaaaca atggaacaat gctgcgtgga 1136641 acggtgtcca gatggtatac ggggatggag acggttcgaa atttaagccg ctgtctggat 1136701 cgctcgacat tgtcgcgcat gaaatcacac acgcagtcac acagtattcc gccggtcttt 1136761 tatatcaagg agaacccggt gcattaaatg agtccatttc tgacattatg ggcgcgatgg 1136821 ctgaccgtga tgattgggag atcggcgaag atgtctatac tcctggtatt gcaggagatt 1136881 cattgcggtc attggaggac ccatctaagc agggaaatcc agatcattac tcgaaccgct 1136941 acacaggaac agaggattat ggcggagtcc atatcaattc gtccattcac aataaagcag 1137001 cttatcttct tgcagaagga ggcgtgcacc acggtgtaca ggttgaaggg attgggcgtg 1137061 aagcaagtga acaaatttac tatcgggctt taacatatta tgtaacggca tctacagatt 1137121 tcagcatgat gaagcaagcg gcgattgaag ctgccaatga tttatacggt gaaggctcga 1137181 agcaatcagc ttcagtcgaa aaggcgtatg aggctgtcgg cattctatga gcaaacaaaa 1137241 acagtcagga cacagagtct gactgttttt gtttgctcat tttcttaaaa agaatatcgc 1137301 caatgtacct ggaccggcat gcgagccgat ggctgaactg attggatgca taatgatttc 1137361 tttcggcttg aacgcttcct caatcaggtg tttcatatcc gtggcttttt ctttgttcgc 1137421 ggcgtagcta atcccgacgg tttgattgct ccaatcatcc ccgcgctctt tcataagctc 1137481 gatgatccgt ttgaaaagtt tcttctgtcc gcgaattttt tccagaggca caagcttgcc 1137541 gtcctccatc tgaagcagcg gtttaatatt caacaggccg ccgacaaaag cggacgtttt 1137601 ggatatccgg ccgcccctcg cgagatatgt taaatcatca acggtaaaaa tgtgttcaag 1137661 ctggctgcaa aagttcttta cagacgtttc aatttcttgt attgtattcc cgttgataca 1137721 gagatcggca gcatgccgga cagccagacc gtatcctaat gaagcgcatt tggaatcaat 1137781 gacccgcaaa tcgaaatcgg ggaattcctc cttcacttca ttggcgatca ttacagctgt 1137841 ctgatacgtg ccggagagac ctgaggaaaa ggcaatgtaa agagcgggat cacctgtttc 1137901 ggcatattgc aaaaacacat ttttaatcgt ttgcggtgag gcttgggacg tcttaggcgt 1137961 ttctccattt tgcatcgctt caaatatttg atccgcatga attgtgactg catcttcgaa 1138021 ttctttatcg ccgagagaaa ccctgagcgg aataaagcca atgccttttt cttcaaaata 1138081 agaacgaggc aaatcagtgg cgctgtcagc gatgagatga actgtcatat tgcttccctt 1138141 ctttccgtta tcgctcgtta tcatgagagt taagccaact atatcatatt aatttgccaa 1138201 aatcgtgttc aaatatttgt tttaagggaa aacataataa agaagaaaga gcggaggaac 1138261 atgccatggt actagatcaa acaaaaaaat tactcatcgt catcatcggc gctttactca 1138321 atgctgccgg gctgaactta tttttgatac ctgcagatgt atatgccagc ggatttacag 1138381 gtgttgccca gcttttatca agcgtcgttg atcaatatgc ccccttttac atatcgacgg 1138441 gaacgctctt gttcctctta aacattccgg tcggtatttt aggatggctg aaggtcggca 1138501 aatcgtttac agtgtacagc attttaagtg tcgcactcac tactctgttt atggggatcc 1138561 tgccggaaac aagcctgtca catgacattt tgctgaacgc ggtgttcggc ggcgtcattt 1138621 ccgcagtcgg tatcggctta acattaaaat acggagcttc gacaggcggg cttgatatcg 1138681 tcgccatggt acttgcaaag tggaaggata aacccgtcgg cacgtatttc ttcattctga 1138741 acgggattat catcttgacg gcaggattat tgcaaggttg ggagaaagca ttatataccc 1138801 tggttacact atatgtgaca acgagggtga tcgacgccat tcacactcgc cacatgaagc 1138861 ttacggcaat gattgtgacg aaaaaagcgg acgaaatcaa ggaagccatt tacggaaaaa 1138921 tggtgcgcgg catcacaact gttccggcaa aaggagcatt tacgaacgaa cagaaagaaa 1138981 tgatgattat cgtcatcacg aggtatgaac tgtacgattt agaaaagatc gtcaaagaag 1139041 ttgatccaaa agcatttacg aacatcgttc aaacgacagg gatttttggt ttctttagaa 1139101 aagactgacg aaagcaggtg gaagtcgtga aacggctgct tgtgatgctc ctccccgtgc 1139161 tgcttttgat aggctgcggg aaagatgagc agacagaacc cgataaggag gtatcaggcg 1139221 gaatggagaa tcaagaggtt gttttatcta ttgacgcaat tcaggagcct gaacaaatca 1139281 agtttaacat gtcgctgaag aaccaaagcg aacgtgctat tgagtttcaa ttcagcacag 1139341 ggcaaaaatt tgaacttgtc gtgtatgatt ctgagcacaa agaaagatac cgttattcga 1139401 aagaaaaaat gtttacgcag gcttttcaaa acctgacgct tgaatctgga gaaacatatg 1139461 atttctctga tgtgtggaag gaagtccctg agcccggaac ctatgaggta aaggtgacat 1139521 ttaagggcag ggcggaaaat ctcaagcagg ttcaggctgt tcagcagttt gaagtcaaat 1139581 aagaggctat ggcgagtcgc catagccttt ttttattgca gtttgtccag ctgattttga 1139641 aattgatgca actgttgacg ttccgcatct gtcgaattgg catacgcaga agatacagca 1139701 tttttggctc tcagaatcgc ttgctcctga tcgccttcct caaagccgtt tgtcaccatg 1139761 accgcctgtt gaacaaatga ttttgcctgc tgaaacagtt catttctcat ttaatattca 1139821 tactgccttt cagccgagtc tcgtgccgcg gcatgctggt gagcttcttc taaagtagac 1139881 cgatatggaa atcttgcggc gtgtagcccg atggagtctt taccctgctg aataaacctt 1139941 ctggatttgc ttcgtttacc cattttgaga ctgccccctt ccatactttg acgagatgag 1140001 tcgtcttcaa tagtatggtg gggtaaagta aggtttatga gtgggaaaaa ttaatacgga 1140061 ccttctttaa agtgagaaat attctttcaa aaaccttgcc acgccgtcct cttcatttgt 1140121 ggccgtagtt cggttggcaa tctgcttgac cgcgtcaatt ccatttccca ttgcaacgcc 1140181 gcagcctgca aattcaagca tttccaaatc gttatcctca tctccaaaag caatgatccg 1140241 ctccctcggc acgccgtaat aatcgctgat tttctgcagg ccgaccgctt tattcatgcc 1140301 gcttttgata atttcaatga catgccaagg agcggcccat cttctatggt cgatcacctc 1140361 ggcatgcaca tccgataaat atgagcgtat tgccggcaca tcctcttcct ttgcatgtat 1140421 gagtacggac gtcacatctt caccgagatt ttcccgcaag tctccgaccg ttacatttgt 1140481 tgtgttcatg ttaaaggcat ctatcaggtg ctcatcatgg taatgaaagt atacgtcgtc 1140541 aatcacttca gcaagcacgt tatgtacgtt gtagctctcg ctgatatcca cgagctgttt 1140601 gacaacatca agcggcagtg acgtatgata ccgtccccag ctgtcgtctt gcggatgatg 1140661 gacaaatgct ccgttaaaat tgacaattgg cgttgtcagc tccatctgct ggtagtacat 1140721 ggaacttgaa cgatacggac ggcctgttga gatgcagaca taatgcccgt catcttttag 1140781 gcgctgtatc gtatgaaggg tgttttcaga tatggtttta tcatccttta ataatgttcc 1140841 atctaaatct aatgcgatta aatagggttt tgtctccatg aaaagctcct ttaaccttag 1140901 attttgcttg ttttgcctta cttacagtgt agctttttac catctttatt gtctacatgt 1140961 tacacttatg attatggtta tcctaaggag gggcacattg tgatacaaat tgagaatcaa 1141021 accgtttccg gtattccgtt tttacatatt gtaaaggaag agaacaggca ccgcgctgtt 1141081 cctctcgtga tctttataca tggttttaca agcgcgaagg aacacaacct tcatattgct 1141141 tatctgcttg cggagaaggg ttttagagcc gttctgccgg aggctttgca ccatggggaa 1141201 cggggagaag aaatggctgt tgaagagctg gcggggcatt tttgggatat cgtcctcaac 1141261 gagattgaag agatcggcgt acttaaaaac cattttgaaa aagagggcct gatagacggc 1141321 ggccgcatcg gtctcgcagg cacgtcaatg ggcggcatca caacgcttgg cgctttgact 1141381 gcatatgatt ggataaaagc cggcgtcagc ctgatgggaa gcccgaatta cgtggagctg 1141441 tttcagcagc agattgacca tattcaatct cagggcattg aaatcgatgt gccggaagag 1141501 aaggtacagc agctgatgaa acgtctcgag ttgcgggatc tcagccttca gccggagaaa 1141561 ctgcaacagc gcccgctttt attttggcac ggcgcaaaag ataaagttgt gccttacgcg 1141621 ccgacccgga aattttatga cacgattaaa tcccattaca gcgagcagcc ggaacgcctg 1141681 caatttatcg gagatgaaaa cgctgaccat aaagtcccgc gggcagctgt gttaaaaacg 1141741 attgaatggt ttgaaacgta cttataaagc actaagttat taacaagagc tgaatttacg 1141801 ttatactgta gaaaaaagga gtgagggaac gtggaagaag cattaaaaga aaacatcatg 1141861 ggcgccctgg aacaggttgt cgatcctgag cttggcgttg atatcgtgaa cctcggcttg 1141921 gtatatgacg ttgatatgga tgaagatggc ttgacgcaca tcaccatgac gctaacatca 1141981 atgggatgcc ctttagcgcc gattatcgtg gatgaggtga aaaaagcatt agcggacctt 1142041 cctgaagtga aagacacaga ggttcacatt gtatggaatc cgccttggac tagggataaa 1142101 atgtccagat acgcaaaaat tgcgcttggc attcaataaa acaaaaaagg acagcctgac 1142161 atgtgaggct gtcctttttt acagctgaaa ggagtgaaag gaaatgatgt acctgctggc 1142221 agttttatgc ccgccgcttg ctgttttgtt ttcgggaaaa ccgtttcagg ccttgctgaa 1142281 tctcatattg acctgtatct tttggctgcc gggcgcgatt cacgcctgct ttatcgtcgc 1142341 cgaccgccgt gccgaaaaac gggcaagaag ataatttgga aaaatgagga cgcagtcatg 1142401 gtataatggt cataaaaaca gcagggagag cactatgaaa aagaaattgc ttgcattcgc 1142461 gctttgtact ggcgcgtatg cggccctgtt tgcgtactct gtgaactcag agcaaaaaac 1142521 agccacaagc gagatgacgg atgtcagccg cctgatgcct gtaaaaataa agcagacagt 1142581 gaaagggcag gaagaggaaa tgctcattga cacagtcaaa gaggcaaatc gaaaaaacat 1142641 aaaaatttca atcgccgggg cccagcactc catgggcggc catacatatt atgaggacgg 1142701 catcgttctc gacatgacgg gctacaacaa aatcctgtca ctcgatcaag agaagaaaac 1142761 catcagggtg caaagcggtg caacgtggaa tgatatccag aaatacgtga atccatacgg 1142821 actcgcggta aaagtcatgc agtcacaaaa catttttaca atcggcggat ctctcagcgc 1142881 aaatgcacac ggacgtgata ttcgctacgg ctcgctaatt gatacagtca aatcattccg 1142941 gcttttaaaa gctgacggga tgattatcac tgtcactcca aaagatgatt tgtttacggc 1143001 ggtcatcgga gggtacggcc tttttggcgt gattcttgat gtaacgcttg agctgacaga 1143061 tgatgagctg tatgtcatga agacagaaaa aatgaattac agcacatact cagactattt 1143121 ttcaaagcat gtaaaaggaa atccagatgt ccgaatgcat ctggcgcgaa tttcaacagc 1143181 gaaaaaagga tttctgaaag acatgtatgt cacgaattac gtattggcta atcatcagga 1143241 tcagctgtcc tcatacagcg aacttaaaga agacgagtat acgggagcca caaagtttgc 1143301 actcggcttg tcaagacggt atgaatgggg gaggaattgg ctgtgggaca cacagcaatc 1143361 ctatttcctg agccagaacg gcacagagat ttcacgcaat aacgtcatgc ggtccgaatc 1143421 aaagtttctt gagtatgaaa acaatgacaa cacagatgtt ttgcaagaat actttgtgcc 1143481 cgtgaaggag tatgggtcct atattgatga cctgagacaa acgctgtcgg acgaagatct 1143541 gaacctgctg aacattacga tccgctacgt gcagaaaaat gaaaaggccg acctttccta 1143601 tgcgaaggac gatatgtttt cgctcgtact attaataaac gagggctttt caaaagaaga 1143661 ccaggcagat accgcccgaa tcatcaggcg catgacagac gttgccatca agcacggcgg 1143721 cagctattat ctgccttata tgacctacca gacaaaagcg caaatgagac aggcatatcc 1143781 gaaaagtgaa gcgttttttc agaaaaaacg aacctatgac ccggatgagc gctttatgaa 1143841 ttacttttat cagaggtata aataatgggg aaaaacaaat taaaatggct gacattatca 1143901 caaagcagcg tgtttttcgc aagcagctta atctttccgt tttatattct gtttgtgaaa 1143961 aatatcggct caagctacac acagttcggt ttttcctacg gattgttcgg gttgagcgga 1144021 gcgcttattt acccgctcct cggacggctg tctgaaaggt ttgacagccg ttattttctg 1144081 cttctgaact cgtgggggat ggctgttctg cttttatatg tcccgcatat cggaagcgtc 1144141 gttcaagtgt atatcgtcca agtgctgtta gggctctttg gagcgatgca aaagcatgga 1144201 gaaaaagtgc tgatcgctaa ttttacagac agtggagagc gtggaaagaa gatcgggaat 1144261 taccattttt ggacagctgt cttttcagca gcagccatta tgctcggggg ctttctcgct 1144321 gactttttca cagtgcaaat gattttttat gcaagctcta ttctatattt tttgagtgga 1144381 ttgatgatga tgaaaacagg ctgacgcggt cagcctgttt ttttatgcgg ctgaaatgcg 1144441 gcaccgcatc aacgtttttg tgctggagtc gtgctgattt tttttgagcg gaattcccat 1144501 tgaacagaaa atttataaat gaataaaaat attaaatata cgattgaatt aatttttatt 1144561 catgttataa tgttaaataa tttcacaaag accaagaggg tgaacttgtt ttgaaaatag 1144621 gaattgtagg tgctacagga tatggaggca ccgaacttgt caggattctt tcgcatcatc 1144681 ctcatgcaga ggaatgcata ctttattcat ccagcggaga agggaatgtc tatagcgagg 1144741 gttatcctca tcttaccggc ttagcggatc agcagctgaa gccgattgat atgaatacga 1144801 tcaaacacga aatagatatc atgtttctcg ctgcgccgcc cggagtatca agtgaattga 1144861 ctccaaagct ggcagacgcg ggaattacgg ttattgatct gtcaggtgat ctgaggataa 1144921 aagaaccggc tgaatatgaa aaatggtata aacggacagc ggcaccgaag gcggtgattc 1144981 aagaggcggt atacggtctg gcagaactga atcaactgca aattcaacag gcgaaactca 1145041 ttgccaatcc aggctgtttt ccaacagctg ttttgcttgg cctcgcgcca ttggctcaaa 1145101 agaaactgct cgatgaatct ttcgttatcg ttgacgcgaa gaccggtgtt tccggagcgg 1145161 gaagaaaagc atccatggga actcattttt ctgagctgaa cgacaatttt aaaatttata 1145221 aagtcaatga acatcagcac acgccggaaa ttgagcaggc gctgaatgaa tggcagccag 1145281 gtctcgggcc cattacattt tcggctcact tggttccgat gacaaggggc atcatggcga 1145341 cgatgtatac cagattaacc tgtgacctaa ccgcagatga cctgcatgat ttatattcgg 1145401 aattttacca agattcatat tttgtgagag tgaggccaaa aggtcagtac ccgcaaacga 1145461 aagaagtgta cggcagcaat ttctgtgata tcgccgtgac cctcgatgag agaacgaaca 1145521 gagtcacgat cgtctcggta atcgataatt taatgaaggg tgccgccggt caggcagtgc 1145581 aaaactttaa tttgatgaat ggctggaatg aagaaactgg actcaccatc acgccaattt 1145641 atccatagaa cgggagagaa tcgaaccatg attcagttaa gtgaagatca aattgtaaaa 1145701 gtaacaggtg atgtatcctc gccaaaaggg tttcaggcaa agggtgtgca ttgcggactg 1145761 cgctactcga aaaaagacct cggcgtcatt atcagcgaga caccggccgt gagtgcagca 1145821 gtttataccc aaagccactt tcaggctgct ccgatcaaag tgacacaaga cagcttaaag 1145881 cacggaccga cactgaaagc cgtcatcgtc aacagcgcca ttgccaacgc ctgcacggga 1145941 gaacagggct taaaggacgc atacacaatg cgggagagct ttgcttcaca gcttggcatt 1146001 gagccggagc ttgtcgctgt ttcatcaacg ggtgtcatcg gcgagcattt agacatggaa 1146061 aaaatccacg cggggatcga actgctgaaa gaaacacctg cgggatcagg cgattttgag 1146121 gaagcgattt taacaactga tacggtgatc aagcagacgt gctatgaact ggcaatcggc 1146181 ggcaaaacag tcacgatcgg cggagcggcc aaaggctctg ggatgataca cccgaacatg 1146241 gccacgatgc tgggatttgt gacaactgac gcggcaatcg aagaaaaagc gctgcaaaag 1146301 gcgcttcggg aaatcactga cgtttcattt aaccaaatca cagttgacgg agaaacatcc 1146361 acgaacgaca tggtattagt tatggcgaat ggctgcgccg aaaacgagtg cctgacagaa 1146421 gaccatccag actggccggt ctttaaaaaa gcgctcttgc tcacttgtga ggatctagct 1146481 aaagagattg ccagagacgg agaaggcgcg acaaaactaa ttgaagccca agtacaggga 1146541 gcgaaaaaca atcttgatgc aaacgtcatt gccaaaaaga ttgtcggctc aaatcttgta 1146601 aaaacggcag tatacggaac agatgccaac tgggggcgga tcatcggagc catcggacac 1146661 tccgcagcac aggtgacggc agaagaagta gaggtttatc ttggcggcca atgcctgttt 1146721 aagaataacg aacctcagcc attctctgaa tctatcgcca aggaatacct tgaaggagat 1146781 gaaatcacca ttgtcatcaa gatggctgaa ggggacggaa acgggagagc gtggggctgt 1146841 gacctgacct atgactatat caaaattaac gcgagctatc gcacgtaata aaggggagcg 1146901 aaatgaagaa aacaatcgtt tttaaatgcg ggggaagcgt catccgtgag ctgtcggagg 1146961 aattttatca aaatctgaaa gagctgaggg cgtcaggctg gaagctggca atcgtacatg 1147021 gcgggggacc ggaaatcaca aatatgctga aacggttaaa tatcaagaca gagttttcgg 1147081 gcggacagag gaaaacaacg aagccggtgc tggaagtggc ggaaatggtt ttatccggtt 1147141 ctgtcaataa atttttcgtt gctgagcttg ccaaacacgg actgcgagcc gcgggcattt 1147201 ctggtaagga tggcggtctt ttggaggctg attatctaga tccggaaaca tacggagaag 1147261 tgggagaaat caaaaaagtc gatgcgtcca tggtgaacgc gctgatggaa aatggcatca 1147321 tccccgttat tgcgccgctg tctatgacaa gcgactgcaa aacgctgaat gtaaatgctg 1147381 atctggctgc ttcagcagtc gccggagcgc ttgaagccga taagctgatg ttcgtcacgg 1147441 atgtcgatgg aatcatgaag gaaaagcagc gtctggacgt cctgacccct aaggagattc 1147501 agatgctgat caagcaggaa gtgatcacag gagggatgat cccgaaggtc aattcagcct 1147561 tgtcagcttt atcagatcag gtgtctgaag tcatgatcgt aaacggtaaa ggatcattct 1147621 tcgcagaaca aacctttcaa gggacaaaaa ttgtcaaagc aaaggaggct gtttcatgag 1147681 cagcttgttt caaacctacg gccgttggga tattgacatc aaaaaagcaa agggaacgta 1147741 cgttgaggat caaaacggca aaacgtacct tgatttcatt caggggattg cggtatcaaa 1147801 tctaggacac tgccatgaag cggtgacaga ggcagtcaaa aaacagcttg acagcgtatg 1147861 gcacgtatcc aacctgtttc aaaacagtct ccaagagcaa gcggcgcaga agctggcagc 1147921 gcatagtgcg ggagatcttg tctttttctg caacagcggc gcggaggcga atgaaggtgc 1147981 gataaagctt gccagaaaag caactggaaa aacaaaaatc atcacttttc ttcagtcgtt 1148041 ccatggccgc acgtatgcag ggatggctgc gaccggacag gataaaatca aaacaggctt 1148101 cggcccgatg cttggaggct ttcactacct gccatacaat gatccttctg cttttaaagc 1148161 tcttggggag gaaggcgata ttgccgcggt gatgcttgaa acagtgcagg gagaaggagg 1148221 agtcaatccg gcgagtgctg aatttttatc agccgtacag tcgttttgca aggaaaagca 1148281 agcccttctc attattgatg aaatccagac cggcatcgga cggacgggaa aaggcttcgc 1148341 atatgagcac ttcggactct caccggatat catcacagtc gccaaaggat tgggaaacgg 1148401 ctttccggtc ggcgctgtca tcggaaagaa acagcttgga gaagcgttta cccctggttc 1148461 tcacggaacg actttcggag gaaacatgct ggcgatggct gctgtgaatg ccacattgca 1148521 aattgtattc cagcctgact ttttgcaaga ggctgctgac aaaggggcgt ttttaaaaga 1148581 acagcttgag gcagagctaa agagcccttt tgttaaacaa atccgaggta aaggattaat 1148641 gcttggaatt gagtgtgatg gcccggttgc tgacattatt gctgaattgc agacattagg 1148701 cttgcttgta ttgccggccg gcccgaacgt gattcggctg ctgccgccgc tcaccgtgac 1148761 taaggatgaa atagcagaag ccgtcagcaa gctgaaacag gcaatcgctc atcattccgc 1148821 tgtaaaccag tgattttttt tcgatataaa ggcataaaaa ttcattttta taattaatta 1148881 ttcatcaaga ggtgggctgt tagatggaag gttatttagt gttagaagat gggacatcgt 1148941 tcagcggcga gctggacggt catgaaaact gcacgggaga agctgttttt ttcacaggaa 1149001 tgacaggcta ccaggaagtg ctgacagatc catcatataa gggacagatt attgtattta 1149061 cctacccgct gattggcaac tacggcataa atgaaaagga ttttgaaagc aagaaaccgc 1149121 aagtaaaagc cgcggttgtc tatgaggcgt gtgatcactt ttctcattat gaagcggtat 1149181 acagcctcaa ggagtatcta cagaaatgga atattccgct gttaacccat gttgatacga 1149241 gggctgtcgt gaagaaaatc cgggcaaacg ggacgatggg tgcgacagtc acagcctcta 1149301 aagaaggagc tgagattgcc cttcaaccag agaatgtggc agagcaggct tccgcccagg 1149361 aaatcagcac attcggcgac gggaataaac atatcgctct cattgatttt ggctataaaa 1149421 agtcaatcgc atcatcactt gtcaaacgag gctgcaaggt taccgtggtg ccataccagc 1149481 aaatggaggc cgtatacaac atcaaacccg atgggctatc gaacggacct ggagatccga 1149541 aagccattca gccatattta ggaaagatca aaagcatcat cagccgcttt ccgactctag 1149601 gcatttgtct cggacatcag ctgatcgcgc tcgcgtttgg agggaatact tttaagctgc 1149661 cattcgggca caggggagct aatcatccgg tcatcgaccg taagacgaaa cgggtcttta 1149721 tgacaagcca aaaccacagc tatgtggttg atgaacagtc gattaatgaa gaagagctca 1149781 ccatcaggtt tcatcatgtc aatgatacgt cagttgaagg gcttgcccat aaaaaactgc 1149841 ctgtcatgag tgttcaattc cacccggaag cccatcccgg acctgcggaa agcgaatgga 1149901 tttttgatga ttatctaaag aatgtgatac cagcaaggag agaaatcgcg catgcctaaa 1149961 gacaccagta tttcaagcat attagtaatt ggctcaggcc cgatcatcat cgggcaggcg 1150021 gcagaatttg attattcagg cactcaaggg tgcatcgcgc tgaaggagga gggctaccgg 1150081 gtaattctcg tcaacagcaa tccggcgaca attatgactg atgaagcctt cgctgatgaa 1150141 atttattttg agcctctgac agcagaaagc ctgacagcca tcattaagaa agaacggcct 1150201 gatgggcttc ttgccaattt aggcggtcag accgcgttga atttagcggt ggagcttgaa 1150261 gaaacgggtg ttttaaaaga gcacggcgtc aaactcctcg gcacatccgt tgaaacgata 1150321 caaaaaggag aggaccggga aaaattccgt tcgttaatga atgaattaaa acagcctgtg 1150381 ccggagagtg aaattgttga taacgaggcc gatgccctcc attttgcgga atccatcggt 1150441 tttcctgtta ttatcagacc agcttacaca ttaggcggaa agggcggagg aatcgcccct 1150501 gataaagaag cctttacagc tatgattaag caggcgctat tagcaagccc gatcaatcaa 1150561 tgccttgtcg aaaaaagcat tgccggcttt aaagaaattg aatatgaagt catgcgtgac 1150621 agcaataaca catgcattac cgtctgcaat atggaaaata tcgatccggt cggcgtgcat 1150681 acaggtgact ctatcgttgt ggcgccgtca caaacattga cagacgaaga ctatcaaatg 1150741 ctgcggacag caagtctgac gatcatctca gcacttgatg ttgtaggcgg ctgcaacatt 1150801 caattcgcgc ttgatccatt cagcaagcaa tattacgtca ttgaagtgaa tccgcgtgta 1150861 agccggtcat cggctctcgc atctaaagcg accggttatc cgattgcgaa gatggccgcg 1150921 aaactggcag tcggatacac tcttgacgag ctgaaaaatc cgctcacagg ctcgacttac 1150981 gcaagctttg aaccggcact ggattatgtg atcgtcaaat ttccgcgctg gccgtttgat 1151041 aaattcaaaa acgcagaccg caagcttggc acaaaaatga aagccaccgg tgaagtgatg 1151101 gcgattgaac ggaatttaga agcggcgata caaaaggcag ccgcgtcgct tgaattaaaa 1151161 aatatcggga cacaccttcc agagctcagc gggttgtcaa ttgatacgct atgggatttg 1151221 gcaatcactc cggatgaccg cagatttttc gttgtcatgg agctgttgag ccgcagcgtc 1151281 tcgattgatg acatccatga aaaaacaaaa attgatccgt ttttccttca tacctttgac 1151341 aacatcatca aattggaaaa ccgcctgatg gaagcaggga gcgatctctc ttttgaatta 1151401 ttgaagaaag caaaggaaaa gggattctca gacgcaacga ttgcctcgct gatcagcaaa 1151461 acagaagaag aggtgcgcgc gcttcgcaag gagatgggca ttacgccttc ctttaaaatc 1151521 gtagatacat gcgcggcaga gtttgatgcg aaaacaaact atttttactc cacatatttc 1151581 ggagagaccg atggagacat cagccgcaaa gagaaaaaac gcgcgctcat tatcggatca 1151641 ggcccgattc ggatcggcca aggcgttgaa tttgattaca gtgctgttca cggtgtgctg 1151701 acactgcaag agcttgggtt cgaaaccatc atgattaaca ataacccgga aactgtcagc 1151761 accgattatg aaattgcgga ccgcctgtat tttgaaccga tgacaacgga gcatattgta 1151821 aacgtggcgg agcaggaaaa tattgatttt gcaattgtgc aatttggcgg tcaaactgca 1151881 atcaatgctg ctgaagcgct cgaaaaagcc ggcattactc ttcttggcac atcatttcaa 1151941 acgctcgacg tgttagagga tcgggatcaa ttttatcagc ttcttgacga gctgggattg 1152001 aagcacgcaa aaggagaaat tgcttataca aaagaagaag ccgcttcaaa agcgagtgag 1152061 atcggctatc cggtgttaat ccgcccatct tacgttatcg gcggaatggg catgatcatt 1152121 gttgactcgc aagcccagct ttctcagctg ctgaatgatg aggacagcat gccatacccg 1152181 attttaattg atcagtatgt gtctggaaag gaagtcgaaa ttgatttgat ttccgacggc 1152241 gaggaagtct ttatcccgac atataccgag catattgaac gggcaggtgt ccattcaggg 1152301 gacagttttg ccattcttcc cggaccgtcc atcacgagcg ggctgcagca gggcatgaaa 1152361 gatgcggcac aaaaaattgc ccgaaaactt tcatttaaag gcatcatgaa cattcaattt 1152421 gtgatcgaca atggaaacat actcgttctt gaagtgaatc cgagagcgag ccgcacggtt 1152481 cctgtcgtca gcaaagtaat gggcgttccg atgattccgc tcgccacacg tctgctggcg 1152541 ggagcgtcct taaaagatct aaatccggca gttcaaaatc atcatggagt tgccgtgaag 1152601 ttccctgttt tttcttctca tgcgatccag gatgtggatg tcaagcttgg accggaaatg 1152661 aaatcaacgg gagaaggcat gtgtgtcgca tatgattcta acagcgcctt gaaaaaaatc 1152721 tatacaagag tctggagtca aaaaggaagc atttatttgc aaaacgttcc ggaagatgtg 1152781 aaggagttag cagaaaacgc aggttttaca atacatgaag gaacatttgc ctcatggatg 1152841 gaacaggaag gaaactcgct ccacattaat ctgagcggtt ctgaagaagc acgcaaagaa 1152901 cgtttggaag ccatgacgca cggcatcccc gtctttacag aagaagaaac tgtgcgggcg 1152961 tttttacaaa gcggttcagg ccatccgcag cctgtatctc tcaaagacct ctataaaaag 1153021 gaagtggcat catgcacaca gtgacgcaaa ccagtttata cggaaaagat ttattaacgt 1153081 taaaggacct tagtgaagaa gatataaacg ccttgctcgc agaagccggt gagctgaaac 1153141 aaaacaaaat tcagcctata ttccatggca aaaccttggc gatgattttt gaaaaatcat 1153201 caacgcggac ccgtgtttca tttgaagcgg gcatggcgca gctgggcggg agcgccctct 1153261 ttctaagcca gaaagatctg cagctggggc gcggtgagac tgtcgctgat acggcaaaag 1153321 tgctgtcagg ctatgtggat gccatcatga tccggacctt tgaacatgaa aaggtggagg 1153381 aacttgccaa agaagctgac attccggtga tcaatggact taccgataaa taccacccat 1153441 gccaggcgct ggcggatctc ttgacgatta aggagataaa agggaagctt aaaggcgtaa 1153501 aagtcgcgta catcggtgac ggaaataacg tggcgcactc cttgatgatc ggctgcgcga 1153561 aaatgggctg tgatatctcg atcgcttcac caaagggata tgaagtgtta gatgaagcag 1153621 ctgaagcggc aaagacatat gcacttcaat ccggctcttc tgtcacgctg acagatgatc 1153681 cgattgaagc tgtaaaagac gcggacgtga tttattctga tgtgtttaca agcatggggc 1153741 aggaagcgga agagcaagaa cgtcttgctg tctttgcgcc ttatcaggtg aatgcggcgc 1153801 tggtcagcca tgccaagcct gactatacat ttttacattg tctccctgcg catcgcgagg 1153861 aagaagtgac tgcggagatt attgacgggc cgaactctgc agtgttccag caggcggaaa 1153921 accgtcttca tgtgcaaaaa gcactgctga aggccatttt atataaaggg gaatcatcaa 1153981 aaaactgctg agccaaactc agcagttttt ttgatggcaa catattcaca gccgcttagg 1154041 cgcatactac agcaaaaagg aaaaggagga aaaacagtgg gacagcagca ccaattccgg 1154101 cccggacaga aagcgcctaa taacggtgtc tacgtagaaa tcggcgagac agggagcatg 1154161 gttaaaaacc ctcaaaaggt ccatctgtca gcaggggaaa tgttccccga aacatcaaac 1154221 cacaaccggc tgtggaccta caaaagaaag ccgtgaccac taaaaaaccc aaaacaataa 1154281 atgttttggg tttttggctt tttaatgctg gcttgcattt ttgttcatag gcatgatttc 1154341 tgctaaaacc atgattaaga catacagtac aacagcaatg acagatgatg ttttgaaatt 1154401 atacgtaacg ctgttcatgc ttgcaaccaa gtagcatgcc atatgtgata aaaggaacgt 1154461 ccaaataaag gcaataatat atcgcacgtt tccacctcgt ccttctcatt ctattctaaa 1154521 agttatcata ccatacaaaa agcgaagggg gaatccaatt ttagcagaaa gtgaggtgac 1154581 aaaagagtct gattcgtcac actttaatgg taaaatataa aacgtcaatc agtataatag 1154641 ccaaaaatgt aaaaggctag gactttacct tattcgtttc ttttctattt acataagata 1154701 gcgtgagatg aagtgtgaaa ggaggcgggc aagcgatggg aataacggaa agatactttc 1154761 aactgggaac ggagcataat gtcattcatc tgccctatcg cccgaacggc ttcggcatct 1154821 ttatcttggg ggacagaacc cactttgtcg gacatgattc aagcttttgg cagcagcatt 1154881 atggcagaaa tcagcttctg agcatgttga tgaatgaagg atacactctt tttaacagca 1154941 atctgttcgg aaggcattgg ggggcggaaa aagcagtcac ctatgccaaa cagctgatac 1155001 attctgtgct gaagcaggaa atcctcaatc cgaagattca tattttagca gaaggcatgg 1155061 gtgctctcgt ggccgatgaa ctgcttcgtt tttccccgga tcatatccgc tcagccgcaa 1155121 tgttgaatcc ttgtctcgat cttcaggcac attatgaatc ggaaaaagaa aataaatttt 1155181 tctataagca atttttgaaa gaagtatcga aaagctacgg aatttctgaa aaagaagcgg 1155241 aagcgattcg ttataaaaca attcaaagct acccgagcgg cgtaccggtt catatatggc 1155301 agcgtatgac cggagctcca tatccctaca gcgtacatgc ggaagttttc aaggaaaaac 1155361 agcaaaagca aggctcaccg gtcgacatga catttcattt atttgagcat ccaagcagaa 1155421 tttatgcatc aatttgcaaa ttctttcata gtcatgaaaa agaattatag agaatataat 1155481 gacaacagcc ttctcttttg cggaggctgt tttgttttgg gaaatgaaaa accggaaggg 1155541 cggcagatgc aatggaatca acgctgattg taggtgcgga cgaatttttc ggcctttcat 1155601 tatgtgagcg aatgatggat gaaggcatac atgttgacgt tgttctggcg gaaacagaag 1155661 ataaaatgag acaaatgtac ttagaagaaa gactcatgtg gcttgggaga aatgaactct 1155721 ttcgccagct tgaacacatt ggagaccaaa attatgatac aatttgtatc cagttcggaa 1155781 gttttttgcc tttagaccaa tatgattctc cttatatttt agtatatgaa gaagaccgaa 1155841 aagaatggga taaacgtgaa aaaacaggct cggaaaaaac cgtgatcctg ccgaaaatgt 1155901 acgggccatg gaaagaagaa acagaggaag acggctatta cacaaacgac gtggctgacg 1155961 agttgctgag attcctgtta gaaccaagcc gtcatagcaa agatcagctt tttgaattgc 1156021 aagtcacaga gaaaacctca aaagaagaag caaaaacaaa aattatcgag tggaaaagac 1156081 aattttcatc aattttcgac aaatattaag aaaaaccttc catgtttcga gttttctaga 1156141 tacaataaac gtataaaaat aatacatgtt atagcttgtc aaaaggagtt gaacatgact 1156201 tgatcacaag gcttgtcatg atcttttctg tcctcctttt attgagtgga tgtggacaaa 1156261 ctccgttcaa aggaaaaatt gagaaggtcg gcatgctctt tcctgatacg attaatgacc 1156321 tcgtatgggg cacaaaaggg tataaaggat tactgaatat acaatccaaa tacaatgtgg 1156381 acgtctatta taaagaaggc gttaaaacag aagaagatat cataaatgcg attgaggatt 1156441 ttcataagag gggcgtcaat ctgctctacg gccatgggag tgaatatgct gaggtgttta 1156501 acttggtcgg cgaagattat ccagatatgg aattcgtcat ttccaatgcg aaagcgaaag 1156561 ctgataatgt aacaagtgtc cattttagcg gggaagcaat gggctttttt ggaggaatga 1156621 ctgctgccca tatgtcgaaa acgaatcagg tcggtgtaat tgcttccttt acgtggcagc 1156681 ctgaggttga cggttttatc aaaggggcca agtatgaaaa tccggatata gaggtaaata 1156741 cgaaatatac ggatcattgg gatgatgata caacagcagt aaagctttat cagaaaatga 1156801 agaacgaagg cgcggatgtt gtgtatcccg ccggagacgg gtataatgtt cctgttattc 1156861 agcaaatcaa aaaagacggt ctttatgcca taggctacgt cacagatcaa tcggatctgg 1156921 gcgagaatac cgtattaacc agcacggtgc aaaatgtgga caaggcctat gaaatcattg 1156981 ctgaacaatt taataaaggc acccttgagg gcggcgatca ttactacgac ctgaacacgg 1157041 gagtcgttga gatgggaaca ttcagcccgc tcgtcgatca agactttcag caaagaatcg 1157101 ccaagctgat caaaacatac aacaaaacag gcgagctgcc aaaaaacgag taatggagtg 1157161 acgtcacatg cagcacgaaa aatcacttga attcttgcaa attgccatga aatatctccc 1157221 tgaagcgaaa gaacagcttg agaaatcagg cattgagctc tcaatggagg ccatccagcc 1157281 gtttatgaat ctatttacaa cggtaatggc ggaagcttat gagcttggca agtctgacgc 1157341 taaatctgaa acagaataag aagaagccac ttttttgaaa gtggcttttc acatgatttt 1157401 ctttttaata gcggagagca tgggcgcaag ctcctttaaa gcgggcttga tttgatcaag 1157461 agagttcata attgaaccga tttggtccat aatatgcatg taattaatcg tctcttcgtc 1157521 gtttgtctga gaaacctgag aaacttcctc ttgctgttcc tcctccttct cttctgttgg 1157581 ttttgctgca tcgccgaaca tcattcttga aaacacatcc aactgcatac gcctcctttc 1157641 catataccat actctatgag taagatgaac tgatagttta gacgaatata ttgccatgtg 1157701 aaaaaaaata ggatagaatt agtacctgat actaataatt gatcacaacc tgattgatct 1157761 tctaaattta agatataaag gagtcttccc taatgaaagc tggaatactt ggtgttggac 1157821 gttacattcc tgagaaggtt ttaacaaatc atgatcttga aaaaatggtt gaaacttctg 1157881 acgagtggat tcgtacaaga acaggaatag aagaaagaag aatcgcagca gatgatgtgt 1157941 tttcatcaca tatggctgtt gcagcagcga aaaatgcgct ggaacaagct gaagtggctg 1158001 ctgaggatct ggatatgatc ttggttgcaa ctgttacacc tgatcagtca ttccctacgg 1158061 tctcttgtat gattcaagaa caactcggcg cgaagaaagc gtgtgctatg gatatcagcg 1158121 cggcttgtgc gggcttcatg tacggggttg taaccggtaa acaatttatt gaatccggaa 1158181 cctacaagca tgttctagtt gttggtgtag agaagctctc aagcattacc gactgggaag 1158241 accgcaatac agccgttctg tttggagacg gagcaggcgc tgcggtagtc gggccagtca 1158301 gtgatgacag aggaatcctt tcatttgaac taggagccga cggcacaggc ggtcagcact 1158361 tgtatctgaa tgaaaaacga catacaatca tgaatggacg agaagttttc aaatttgcag 1158421 tccgccaaat gggagaatca tgcgtaaatg tcattgaaaa agccggactt tcaaaagagg 1158481 atgtcgactt tttgattccg catcaggcga acatccgtat catggaagct gctcgcgagc 1158541 gtttagagct tcctgtcgaa aagatgtcta aaactgttca taaatatgga aatacttctg 1158601 ccgcatccat tccgatctct cttgtagaag aattggaagc cggtaaaatc aaagacggcg 1158661 atgtggtcgt tatggtaggg ttcggcggag gactaacatg gggcgccatt gcaatccgct 1158721 ggggccgata aaaaaaggtg aggtgcacac aagatgacta aaaaaagagt agttgttaca 1158781 ggacttggag cattatctcc acttggcaac gacgtcgata caagttggaa taacgcaatc 1158841 aacggtgtgt ccggaatcgg tccgatcact cgtgttgacg ctgaagaata tccggcaaaa 1158901 gttgccgctg aattaaaaga ttttaatgtt gaagattata tggataaaaa agaagccaga 1158961 aaaatggacc gctttacaca atatgcggtt gtggctgcga aaatggcggt tgaagatgca 1159021 gatcttaaca ttaccgatga gatcgcgccg agagtcggtg tttgggtagg ctccggtatc 1159081 ggaggacttg aaacactaga gtctcaattt gaaatcttct taacaaaagg cccaagacgg 1159141 gtaagcccgt ttttcgtgcc aatgatgatt cctgacatgg cgacaggcca gatttctatt 1159201 gcattaggag caaaaggggt gaactcttgt acggttacag catgtgctac aggaacgaac 1159261 tccatcggtg acgcgtttaa ggttattcag cgcggtgatg cagacgtgat ggtcacaggc 1159321 ggaacagaag cgccgctgac aagaatgtca ttcgccggct ttagtgccaa caaagcgctg 1159381 tctactaatc cagatccgaa aacagcgagc cgcccgtttg ataaaaaccg tgatggcttt 1159441 gtcatggggg aaggtgcagg gattatcgtt cttgaagaac ttgagcatgc cctggcccgc 1159501 ggcgctaaaa tttacggaga aattgtcggc tacggctcaa ccggagacgc ttatcatatc 1159561 acagcgccgg cccaagacgg tgaaggcgga gcgagagcga tgcaagaagc cattaaagat 1159621 gcaggcattg cacctgaaga aattgattac atcaatgctc acgggacaag cacgtattac 1159681 aacgacaaat acgaaacaat ggcgattaag accgtttttg gcgagcatgc gcataaactt 1159741 gcggtaagct ctacaaaatc gatgacaggc cacctcttag gagcagccgg cggtattgaa 1159801 gccattttct ctatcctggc cattaaagaa ggcgtgattc cgccgacaat caatattcaa 1159861 acacctgacg aagaatgtga tttggattat gtgcctgatg aagcccgcag acaggaactt 1159921 aattatgttc tcagcaactc attaggattc ggcggacaca acgcaacatt aatctttaaa 1159981 aaatatcaat cataatcaag ccaaaccggc tgcccttaaa gggtagccgg ttttttttgt 1160041 gtgcatagga ttaaaagagg aggcgatcac atgagtgtag aacaaacata tagctggctc 1160101 aggaaggccg gttcaataga tgatttggcg cattacatta tcccgctttt ttcaggtgcg 1160161 gagaaaaaga actggaaggg cattctgggg catcttcagc atcatgggat gtttaaaaac 1160221 ataaaagagg gtattcagac ggtttccaag ctgaaggaaa aaggttttta cggacatatc 1160281 caaaaggaag aacagtacct caaaaacaaa tggcaaggtc ctgatgtacc aattgttacg 1160341 ctgccggttg atgaacgaaa caggagaatc cgtttagaat tcggatcaaa atcaggactc 1160401 gcctttcaag acaaaatgtt cctttttctt tcgtcagatt tagattttgg gtcggtatct 1160461 gcccttatga cgcatgagta tcatcacgtt tgccggttag gtcatctgac aaaagaggaa 1160521 aaggatgtca cattacttga tacaatcatc atggaagggc tggcggaata tgctgtttat 1160581 gagaggttcg gccgaagtca aacggctgaa tggacgactt ggtatacacc ggaacagctt 1160641 caggctttat atgaaaaaaa gattgcgccc catcgggata tcaaacggga taatcgatta 1160701 tttccccagc tgttattcgg caaaggatat cagccaaaaa tgcttggata cgcagttgga 1160761 ttcaatattg taaaaaaata tttaaccgcc agcaaggcaa gcaccgcaga cgggctgtcc 1160821 attcctgctg agaccttttt ggatgcaatg ctttaaaagg ataaaataat ggaatttcat 1160881 taataatatt acatttatcc taaaaaattc ttgattttgc aaaatgattg taataatata 1160941 caactataaa atttttcgat aattcaatat tatttattat ttctgaataa agggattgct 1161001 ttctcttgaa aacgtttgac aacaagaggg gggaaagggg agctagcatg agcacacttt 1161061 tagaagtgaa taatttaaag acttattttt tcaggaaaaa ggagccgatc cctgcggttg 1161121 acggagtcga ttttcacatc agcaaaggcg aaaccgtcgc gcttgtaggt gaatcgggct 1161181 ccggaaaaag cattacttct ttatcaatta tgggcctcgt ccaaagctca ggcggaaaaa 1161241 tcatggacgg ctctattaaa ctcgaagaca aagacctcac ctcattcact gaaaacgatt 1161301 attgcaaaat ccgcggtaac gaagtatcca tgatctttca ggaaccaatg acctccctta 1161361 atccggtgtt aacaatcgga gaacaaatta ccgaagtgct gatttaccat aaaaacatga 1161421 agaaaaaaga agcccgtcaa cgagctgttg aactcttgca gatggtcggt ttctcccggg 1161481 cggagcaaat tatgaaggag tacccgcatc ggctgtccgg cggtatgaga cagagggtga 1161541 tgattgccat cgcactgagc tgtaatccta aactgctcat tgctgatgaa ccaacgacag 1161601 cgctggacgt gacaatacaa gcccaggtgc tggagctcat gaaagatctc tgtcagaagt 1161661 tcaatacatc gattcttctc atcacacacg acttaggtgt cgtgtctgaa gctgccgata 1161721 gagtgattgt catgtactgc ggacaagtcg tagaaaacgc cactgttgat gacttatttt 1161781 tagaaccgct tcatccgtat acagaaggcc tgcttacgtc aattcctgtt atagatggag 1161841 agattgataa attaaatgcg attaaaggca gtgtgcctac accggataat ctgccgccgg 1161901 ggtgccgttt tgccccaagg tgcccgaaag ctatggataa gtgctggaca aatcagcctt 1161961 cgcttttgac acacaaaagc ggaagaacgg tgagatgctt tttatatgag gaagagggtg 1162021 ccgaacaatc atgacagcag ctaatcaaga aacaatctta gagcttcgtg acgtaaaaaa 1162081 atactttccg atccggtcag gcctttttca aagaaaagtc ggtgatgtaa aagcggtgga 1162141 tggtgtttca ttttcgttaa aaaaaggaga aacactcgga atcgttggag agtcgggctg 1162201 cggaaaatcg actgccggca gaacgatgat cagactgtac aaaccgacag agggccaaat 1162261 tctttttaaa gggcaggata tttccaatct gtcagaggag aagctgcgga agagtgtccg 1162321 caaaaatatt caaatggttt tccaagatcc atttgcttcg ttaaacccga gaaagaccct 1162381 gcgttccatc ataaaggagc cgtttaatac gcacaacatg tataccatgc gtgaacgaaa 1162441 cgaaaaagtt gaagagctgc ttgcaagagt agggcttcac ccgtcgtttg ccggccgtta 1162501 tccccatgag ttttcaggcg gccagcgtca gcggatcggc attgccagag cactcacttt 1162561 gaatccagag ctgatcattg cagatgagcc ggtttccgca cttgatgtat ccattcaggc 1162621 ccaagtgatt aacttgatgg aggaattaca ggaagaattt aatcttacgt atctatttat 1162681 ctctcatgat ctgagtgtcg tccgccatat cagcgacaga gtcggagtaa tgtatcttgg 1162741 caaaatgatg gaactgaccg gcaagcatga gctttatgac aacccgcttc acccatatac 1162801 ccaagcgctt ttatcctccg ttccggttac aagaaaaaga ggttctgtca aacgtgaacg 1162861 cattgtcctg aagggagaac tgcctagtcc ggccaacccg ccaaaaggct gcgtattcca 1162921 cacaagatgt cctgttgcaa aaccgatatg caaggaacaa ataccagaat ttaaagaagc 1162981 tgctcccagc cactttgtgg cttgtcacct ttatagctaa tgttgcccgc acagctttga 1163041 gagggggtat gcacactaca taaacaacag cctagaagaa cgaacatttc aagaggggga 1163101 atatctaatg aaaagacgga aaaccgcact gatgatgcta agtgtattga tggttctggc 1163161 catcttttta tcagcctgct cgggatcaaa atcaagcaac agcagcgcga aaaaatcagc 1163221 aggcaaaccg cagcaaggcg gggatttggt tgttggttca atcggagaac ccacactttt 1163281 taactctctg tattctaccg atgacgcaag tacggatatt gaaaatatgc tgtacagctt 1163341 tttaacgaaa acggatgaaa aactaaatgt gaaattgtca ctcgctgaaa gcattaaaga 1163401 attagacggc ggccttgcat atgatgtgaa aattaaaaaa ggcgttaagt ttcatgacgg 1163461 aaaagaactg actgcagacg acgtcgtatt tacgtacagt gtccctttaa gcaaagatta 1163521 caagggagaa cgcggttcaa catatgaaat gctgaaatcc gtagaaaaaa aggcgattac 1163581 gaagtcttgt ttaagctgaa atataaagac ggtaatttct acaacaatgc gttagacagc 1163641 acagctattc tgccgaaaca tattctcggt aatgttccga ttgctgattt agaagaaaat 1163701 gagtttaaca gaaagaaacc aatcggttca ggaccattta agtttaagga atggaagcag 1163761 ggccaatata ttaagctcga agcgaatgat gattactttg aaggaagacc gtatttagat 1163821 actgtgacgt ataaagtcat tcctgacgca aatgctgccg ttgctcagct gcaggcaggc 1163881 gatattaatt tctttaatgt gcccgccact gactacaaaa cggctgaaaa attcaacaac 1163941 ctaaaaatcg ttactgattt ggcattaagt tatgtgtaca tcgggtggaa tgaaaaaaat 1164001 gaattattca aggataaaaa ggttcgtcaa gcgctaacaa ccgctcttga ccgcgagtca 1164061 atcgtcagcc aagtattaga tggagacggc gaggtagctt acattccgga aagcccttta 1164121 tcttggaact atcctaaaga tatagatgtt ccgaaatttg agtacaacga gaaaaaagcg 1164181 aaacagatgc ttgcagaagc cggctggaaa gatacgaacg gtgacggcat tctggataaa 1164241 gacggaaaga aattctcgtt tacccttaaa acgaaccaag gaaacaaagt ccgtgaagac 1164301 atcgctgtcg tcgttcagga acagctgaaa aaaatcggca ttgaagtgaa aacccagatc 1164361 gttgaatgga gcgctctcgt tgaacaaatg aatcctccga attgggattt tgatgcaatg 1164421 gtcatgggat ggagtttatc cacattcccg gatcaatatg atattttcca ttcaagccag 1164481 attaaaaagg gtttgaacta cgtttggtat aaaaatgccg aagcggataa actcatgaaa 1164541 gatgcaaaat caatcagtga cagaaagcag tattcaaaag aatatgagca aatctatcaa 1164601 aaaattgcgg aagatcagcc gtatacgttc ttgtattatc ctaacaacca tatggcaatg 1164661 ccggaaaatc ttgaaggata caaatatcat ccgaaacgtg atttgtataa tattgaaaaa 1164721 tggtggcttg caaaataaat ttcccttaaa ggggagggag agcgttttct ccctcttctg 1164781 tttttaataa ggaaagtaaa gggggacaag tatatggctg catatattat cagaagaacc 1164841 ttaatgtcta tcccgatttt attgggaatt acgattttat catttgttat catgaaagcc 1164901 gcgcccggag atccgatgac attaatgatg gacccgaaaa tcagccaggc tgacagagag 1164961 cagtttattg aaaaatacgg tctgaatgat cctcagtacg ttcaatattt aaagtggcta 1165021 ggcaacatgg tgcagggtga tttcggaacg tctattgtca gaaaaggaac gcctgtttca 1165081 gaattgatta tggcaagact acccaatacg ctcctgctga tgctggtttc aacgattttg 1165141 gctcttatga tttctattcc gttcggtgtc ctgtcggcaa agcggccgta ttcaaaaatc 1165201 gactatggca ttacatttac ctcgtttata ggcctggcta ttccaaactt ttggtttgga 1165261 ttaattttga ttatggtgtt atcggtaaat ctcggctggt ttccaactgg gggtgtcgag 1165321 acactgaata ccgaattcaa tatatttgac cggattcatc atttaattct gcctgcattc 1165381 gttctagcta cagctgacat ggccggactg acgagataca cgagatccaa tatgcttgat 1165441 gtattaaatc aagattatat tcgcacagcg agagcaaaag gatttaaaga gaacagagtg 1165501 ctatttaaac atggattgag gaatgcatta ttacccgtca ttacaatttt cggtttgatg 1165561 attccttcat ttatcggcgg atctgtcgtt gtcgaacaaa ttttcacttg gccgggatta 1165621 ggaaagctgt ttgtcgattc agcattccag cgcgattatc cggttatcat ggcaatgact 1165681 gtgatctcgg cggttcttgt cgttgtcgga aacctcattg cagacatcct ttacgcgatt 1165741 gttgatccgc ggatcgaata ttaaaaggag ggaaacagag atgtcagagc tgcaaacaac 1165801 tccctcgccg gagatcaggc tgaaagaaaa tatttcgaaa aagccagaaa caatgacaaa 1165861 gattttctgg gaaaaattct cgaaaaacaa actggccatt ttaggtgccg ttattctttt 1165921 tatcattatt atgtctgctg ttttcgcccc tttaattgca ccttatcccc aagagcagca 1165981 aagcctgctt gataaatata aggcgccggg ccttgaacat ctgatgggaa cggataaatt 1166041 tggacgtgat attttcagcc ggatcctata tggagcgcgt gtctctttat tggttggatt 1166101 tgcgtccgta gtcggttcga ttttgatcgg aacggtttta ggagcattag ccggatattt 1166161 cagaggaata gtggatgctg tcattatgcg tgtagttgac attgtgttat ccattcctga 1166221 tattttcttg ttgatcacgc tggtcaccat cttcaagccg ggtgtggaca aattgatttt 1166281 aattttctgt ctcacaggat ggaccacaac agcacgatta gtaaggggag aattcttgtc 1166341 gctccgttca agggaatatg ttcttgctgc taaaacaatt ggaacaaaaa cgcacaaaat 1166401 tattttttct catatcctgc ccaatgcgtt agggccgatt atcgtgtcag ctacgctgaa 1166461 agttgggtct gttattctag ctgaatcggc gctaagctac ttgggctttg gaatccagcc 1166521 gccaatcgct agctggggga acatgcttca agacgcacag aatttcacag taatgattca 1166581 agcatggtgg tacccgttat ttcccgggct atttatttta atgaccgttt tatgcttcaa 1166641 ctttgtcggt gatggcctgc gggatgcgct tgacccgaaa aatattaaat aaaaatgaat 1166701 atcatatctg ttataaaata tcaccaaatc agaaaaaagc aggtctcctt tagtcagaaa 1166761 atatacaaag agatctgctt tttatgattc ttacataaac ccagtgattc cagatttcct 1166821 caatctcttt ggaataattt ctctatccct tgcctatact gtggacaaca gtttttataa 1166881 aagtgagggg ttagagatgt tatttcttca tgatgtgtgg gtcaattggt ttgaagggga 1166941 agaaaatggc tacaatgtat gccactttca cgaatggcgc aaggaagata cggttgagct 1167001 tttggatcag gtgccgctgt taagggtgcc gtcagtactg tttcattaca tagaaaacga 1167061 tttgtcagag cttccgaaag gtttgcttga agacgtacat cagaaatcgt acattcgaaa 1167121 aaatcatgag cggacaaagc ttgagtattg ttttgtcgta acagacggaa tcggcatttt 1167181 agctgttgac acgatcggct acacgatccc tgtcagaaaa agccgtctaa tcccaagaca 1167241 ggagcagctc gtttatgaaa tggtaaaaga tgtagagcct gaaacatatg aatttgagcc 1167301 aaagaagctg gaatcctcca aggaatatca catcttatca ttagcaccag aacatgtcag 1167361 aggactgaca agaaaagaac ggcaaattaa gcagctgatg tttatggcgc ttgaccaatt 1167421 aaaagggctg aaaaaccgag cggaaattgg ctactggtac acagagtgga atccgcatat 1167481 gtatgaacaa atcaaaagga tgagctttga agagatttgg gacatgctgt ataacgaaac 1167541 aattgaaggc tggtcggaca aacacctagc tttttgcgaa aacctaataa aaggacagcc 1167601 ttttttcgaa aagctttggg aaatggaaaa cgaatcaaag gtcaactgaa aaaaaccgct 1167661 ctttgcaaag agcggttttt tgattagcgt ctttttcttc caagacccat ggcattctcc 1167721 atttttttca gcattttgtt tgctgtccga ttcgctcgtt ccgcgccttc atcaagaatc 1167781 cggtctaatt cttcagattc tatcagctcg taatagcggt cctggatcgg ttttaatgcg 1167841 ttcactacga cttctgccaa atcaccttta aactcgccgt agccttttcc ttcgtacttt 1167901 gcttcaagct cttcaattgt cgtattgccg aggattgaat aaattgtaag aaggttggaa 1167961 acgcccggtt tgttttcctt atcaaatttg acaatgcctt cagaatccgt tactgcgctt 1168021 ttgattttct tttcaagctg cttcggctca tccagcaatg taatataagc tttctgattc 1168081 ggatcagatt tgctcatttt cttcagcgga tcattcagag acatgatacg tgcaccgact 1168141 tttggaattt tcacttccgg aatcgtaaag atgtcgttgt attttttgtt gaagcgttct 1168201 gcaagattcc gcgtcagctc aaggtgctgc ttttgatcct cgccgacagg tacaagatcc 1168261 gttccgtaca gcagaatatc agcggccatc agcggcggat atgttaacag gccggagacg 1168321 acagcttcat tgcctttgga tttgtcctta aattgagtca tccgctcaag ctcgccgata 1168381 taggcgacac actgcatcat ccatccggcc tgcgcatgtg cggggacctc tgactgaata 1168441 aacaatgttg ctttttctgg atcaagtccg acagctaagt aaagcgccgc gagattgcgg 1168501 atattctttc taagctcaag ccggtcttga ggaacagtta tcgcatgctg atcgacgatg 1168561 caaaaatagc tgttataatc atgctgcagt tcgacaaact gcttcattgc accgatatag 1168621 ttgccgagcg tcactgagcc gcttggctga atgcctgaaa aaatcgtttg tttcatgaaa 1168681 acatcaacct catttcttaa aacataataa aaaaggctca ttcttcccct gtaaaaaagg 1168741 gacgaatgaa ccgtggtacc accctgatta ttccattaaa atggaatcac tctgacgttt 1168801 gtaacggaga ctgctccggc tgagcctact tttttccagt tcggtcagct gctccaaagt 1168861 ccattccaca ttgcccgtta tctgctccca gcaccgcaga ctctcttcaa acaggtgaaa 1168921 cgtgtactac tctttttcat agcaagcttt tcttttgatt gcttcattat aaatcaatta 1168981 taaccaattg tcatcatgaa aaaacattct tttttccagt aaaattgtaa taatataaat 1169041 aacacgagtg ctgtaaaatc cttaaatgat aactgctatc agcgtaaaaa caggcagata 1169101 ttatatgtaa aaagcaatat gggcagaaaa cacatgaaaa agtttttaat caatttatgc 1169161 tttaaatggt agaaggatat tatgttcatg gaagaaaaac taacgaagtt taaatatttt 1169221 aaattgataa aataatattg caataaatta tttgtttcat tataatgaac ttgttcactc 1169281 tattgttaca gcttttttac aaaaataatc agaaaagacg gaacagaata aaagttgtgg 1169341 aaactcaggt tcatttgtct gatatttctg aggatttagc cgtaaggagc tgaaaattat 1169401 tattaggggg tttgcgaata tgaaaaaacg ttggtcgatt gtcacgttga tgctcatttt 1169461 cactctcgtg ctgagcgcgt gcggctttgg cggcagcgga tcaaacggtg aagggaaaaa 1169521 ggacagtaaa ggaaagacga cacttaacat taatattaaa actgagccgt tctccttaca 1169581 tccgggattg gcaaatgatt cagtatcagg cggtgttatc cgtcagactt ttgaaggatt 1169641 gacacgtatc aatgcagatg gtgagcctga agaaggcatg gcttctaaaa ttgaaacgag 1169701 caaggacgga aagacatata catttaccat tcgtgatggt gtgaaatggt ctaatggaga 1169761 ccctgtaact gcacaagatt ttgaatatgc ttggaaatgg gcgcttgacc ctaataatga 1169821 atcacaatac gcttaccagc tctactacat aaaaggtgct gaagcggcga ataccggaaa 1169881 aggcagccta gacgatgtgg cagtaaaagc tgtgaatgac aaaacgctga aggttgaatt 1169941 aaataacccg actccatatt tcactgaatt aactgcgttc tatacgtata tgccgatcaa 1170001 taagaaaatt gcagagaaaa ataaaaagtg gaatacaaat gccggagatg attatgtatc 1170061 aaacgggccg ttcaaaatga cggcatggaa acacagcggc tctattactc tcgaaaaaaa 1170121 tgaccagtat tgggataaag acaaagtcaa actgaagaaa atcgatatgg ttatgatcaa 1170181 caataacaat acggaactaa aaaaattcca agctggcgaa cttgattggg ccggtatgcc 1170241 gctcggacag cttccgacag aatccctgcc gaccctgaaa aaagacggtt ctttacatgt 1170301 tgagccgatt gcaggagtgt attggtacaa attcaacact gaagctaagc cattagacaa 1170361 cgtcaatatc cgtaaagctt taacatattc gcttgaccgt cagtcgattg ttaaaaacgt 1170421 tacgcaagga gagcaaatcc cggcaatggc tgcagtgccg cctacaatga agggatttga 1170481 ggataacaaa gaaggatact tcaaagacaa tgatgtcaaa acagcaaaag aataccttga 1170541 aaaaggccta aaagaaatgg gcttaagcaa ggcatctgat ttgccaaaaa tcaaattgtc 1170601 ttacaacact gatgacgcac acgcgaaaat cgctcaagca gtacaagaaa tgtggaagaa 1170661 aaatttaggc gttgatgttg agcttgataa ctcagagtgg aatgtctata ttgataagct 1170721 ccacagccaa gattatcaaa tcggccgtat gggctggctc ggcgacttca atgatcctat 1170781 caacttcctt gaattgttcc gcgacaaaaa cggaggaaat aacgatacag gctgggaaaa 1170841 tccagaattc aaaaagcttc tgaatcagtc acaaactgaa acagataaaa caaaacgtgc 1170901 agagctgctg aaaaaagcag aaggtatttt cattgatgaa atgccggttg ccccaatcta 1170961 tttctatact gatacttggg tacaggatga aaacctaaaa ggtgttatca tgccaggtac 1171021 tggtgaggtt tatttcagaa acgcatattt taaataaggc tacgtctgaa aataaaagac 1171081 ctcaaggtat atggggagaa aagccccata tacctttctt actgatggag tataaaaatg 1171141 taaaaaccat ggaggtgttc ccccttgcta aaatatatcg gaagacgctt agtctatatg 1171201 attatcacac tatttgtgat tgtaactgtg acattcttct taatgcaagc agcaccgggc 1171261 gggccatttt caggtgagaa aaagcttccg cctgaaattg aagcaaattt aaatgcgcat 1171321 tatggcttgg acaagccgct gtttgtacaa tatgtcagtt atttgaaatc agttgcaatg 1171381 tgggatttcg gaccgtcatt taaatataaa ggtcagagtg ttaacgacct gatcagttca 1171441 ggtttccccg tttcatttac tcttggagca gaagctattc tcctcgcttt agcgttaggt 1171501 gtattgtttg gggtcattgc agccctttac cataataagt ggcaggatta taccgtcgcg 1171561 attttaacga tatttggtat ttcggttccg agctttatca tggcggctgt tctgcaatat 1171621 gtgttctcca tgaagcttgg gctgtttccg gtcgcggggt gggattcctg ggcatacacc 1171681 tttttgcctt ccatcgcact tgcttccatg ccgatggcgt ttattgccag actttcccgt 1171741 tcaagcatga tcgaagtgtt aaacagtgat tatatccgca cagcgaaagc gaaagggctt 1171801 tcccgcccag cggttacagt gcggcacgcc attcgaaacg cacttttgcc ggttgttaca 1171861 tatatgggcc cgatggccgc acaggtctta acggggagct tcattattga aaccattttt 1171921 gggattccgg ggcttggtgc acacttcgtc aacagtatta caaaccgtga ttatacggtc 1171981 attatgggtg taacggtgtt cttcagtgtc atcttgctat tgtgtgtatt aatcgtagat 1172041 gtgttatacg gcattattga tccaagaatc aagctttcca aagcaaagaa aggagcctag 1172101 gccatgcaga acattccaaa aaacatgttt gaaccagccg cagcgaatgc cggcgatgca 1172161 gaaaaaataa gtaaaaagag cctttccctc tggaaagatg cgatgcttcg cttccgcagc 1172221 aataagcttg caatggtcgg gcttatcatt atcgtactta ttatccttat ggcaattttt 1172281 gcgccgatgt tctcaaggta tgattattca actactaatc tcttaaatgc ggataagccg 1172341 ccttcaaaag atcactggtt cggaacagat gatcttggac gggacatttt cgtccgtaca 1172401 tgggtagggg cgcgaatctc aatctttatc ggtgttgcag ctgctgttct cgatttgctg 1172461 atcggcgtca tttgggggag catttcaggc ttccgcggag gaagaacaga tgaaatcatg 1172521 atgcgtatcg ctgatatcct ttgggcagtt ccttcattat taatggttat cttactgatg 1172581 gttgttcttc cgaaaggtct atttacgatt attattgcca tgacgattac aggctggatt 1172641 aatatggcca gaatcgtgcg cggacaagtg ctgcagctga agaatcagga gtatgtgctt 1172701 gcttcacaga cactgggtgc aaaaacatcc cgtcttctat ttaaacatat cgtgccaaac 1172761 gcaatgggtt ctattttggt cacgatgaca ctgacagttc ctactgcgat ttttacagaa 1172821 gcctttttaa gctatttggg acttggtgtt ccggctccgc tggcaagctg gggaacgatg 1172881 gcttctgacg gattgcctgc attgacctat tatccgtggc gtttattctt ccctgccgga 1172941 tttatctgca ttacaatgtt tggttttaac gttgtcggcg acggattaag agacgcattg 1173001 gatcctaagt tacgtaaata agggagtgat acgggtgaca cgcctattag aagtaaaaga 1173061 tttagcaatt tcatttaaaa catatggcgg agaggtccag gcgatccgcg gagtgaattt 1173121 ccatctggat aaaggggaga cgctggccat tgttggagaa tcaggttccg gaaaaagtgt 1173181 aacctctcaa gcgattatga agctgattcc aatgcctccg ggttatttca aacgcggtga 1173241 gatcctgttt gaaggaaagg atctggtgcc gctgtccgaa aaagaaatgc aaaatgtccg 1173301 gggaaaagag atcggcatga tattccaaga tccgatgacc tctttaaatc caacgatgaa 1173361 ggtcggtaaa caaattacgg aagtgctttt taaacacgaa aagatctcga aggaagcggc 1173421 taaaaaacgc gcggttgaac tgctggaatt agtcggtatc ccaatgccgg aaaagcgggt 1173481 gaaccaattt ccgcatgaat tttcaggcgg gatgagacag agggttgtca ttgccatggc 1173541 gcttgcagcg aatccgaaac ttctgatcgc cgatgagccg acaactgctc ttgatgtaac 1173601 gattcaagcg caaattttgg aattaatgaa ggatttgcaa aagaaaattg acacgtccat 1173661 catctttatc acacacgatc ttggtgttgt ggctaacgtt gctgaccggg tcgctgtcat 1173721 gtacgcggga cagattgtag aaactggtac ggtagacgaa atcttctacg acccgagaca 1173781 tccgtacact tgggggcttc ttgcatccat gccgacactg gaaagttcag gagaggaaga 1173841 gctgactgca attccgggca cgccgcctga tttgacaaac ccgccaaaag gagatgcttt 1173901 tgccctgcgg agctcttacg cgatgaaaat cgattttgaa caggagccgc caatgtttaa 1173961 ggtatccgat actcattatg taaaatcgtg gctgcttcat cctgacgcgc caaaggtaga 1174021 gccgcctgaa gcggtaaaag cgaaaatgcg taaactggca aacacgtttg aaaaacctgt 1174081 cttagtgaga gaagttgaat gaattgactg aaaaactatt agaaatcaaa catttaaaac 1174141 agcactttgt cacgccgagg ggaacggtta aggctgtaga tgatttatca tttgatatct 1174201 ataaaggtga aacattaggg ctggttggtg aatctggctg cggtaaatcg acaacaggcc 1174261 gaagcattat caggctgtac gaagcaaccg atggtgaggt gctgttcaac ggcgaaaatg 1174321 tgcacgggag aaaatcgcgg aaaaagctgc tggaattcaa ccgcaaaatg cagatgattt 1174381 tccaagaccc ctatgcatcc ctgaatccga gaatgacagt tgctgatatt attgctgaag 1174441 gccttgatat tcataagctg gcaaaaacga aaaaagagcg gatgcagcga gttcatgaac 1174501 tattggaaac agtgggattg aacaaggaac acgcgaaccg ctatcctcat gaattttccg 1174561 gcggccagcg ccaaagaatc gggattgcca gagcgcttgc tgttgatccg gaattcatta 1174621 tcgcggatga gccgatttcc gctttggatg tatccattca agcgcaggtc gtgaatttaa 1174681 tgaaagaact gcaaaaagaa aaagggctca catacctgtt tattgcccac gatttatcga 1174741 tggtcaaata catcagtgac cgcattggcg tcatgtattt cgggaaactg gttgagcttg 1174801 cgccggcaga tgagctttat gaaaatccgc ttcacccata tacaaaatca ttgctttctg 1174861 cgattccgct tcctgatccg gactatgaga gaaatcgcgt tcgccagaaa tatgatccgt 1174921 ctgtccatca attaaaggat ggggaaacga tggaattccg tgaagtcaaa ccgggacatt 1174981 ttgtgatgtg cacggaagcc gaatttaaag ctttttcatg attcatcaat ccttcaagag 1175041 atttctcttg aaggattttt ttgcgtcttc atagaaagtg agaatgataa catttacaat 1175101 tagaggaaaa agcggaggcg aaatacgatt caatttctgc ataacaaaaa tgtttttgcg 1175161 ctattgctgt ctcaatcttt tcaatcttta gcaggagtcc tcgtcacaat cgttttaatg 1175221 gtccggatct atcaaatgac tgactccgtt tttttggcgg gccttatttt atcgttcatg 1175281 tcgtttgcga gtatagcagc aagcttttgc gtctctccgg tgcttcgcat tctcggtttt 1175341 aaaaaggtgc ttgcgggagc gaatctgctg agagcggtct ttattatact gatggcatac 1175401 agcgtcactc atcacggaca ggcattcttt tggattacgc tgctgtttgt gttttgtttt 1175461 tccttcgcgg gcgctttttt tcagccggca agatttgcgc tgctgccgat tattgttcca 1175521 aagaagcaat atgtaaaagc gaatggtgtg atctccctct cgaatcaatt gttcttaaca 1175581 gcaggctggg gccttggagg ccttctgacg tacgccgtcc cttttgaact cgttgtcggc 1175641 gctgccattt gcctgtttgt tctatcggga gcttccatca gtgtgctgca tgtaaatgaa 1175701 gaagaggctg caggaactgc tgaaacagca tctgtcagaa gtatatggaa ggatttaatg 1175761 atcatcccta ttgtaagaga cattactgta atggacatgt tagaagcttt ggcgggttcc 1175821 gtatggtcat ctgctattct cctcgcattt actgcggctg ttttgcatga aacagaggtg 1175881 tggtggggga tgtttaacgc ttcctatttt ataggcgcaa ttgtcggcag tgtgattgct 1175941 attcgttttt cttctttttt tgagcggaat atgggctatg ccattatgtt cagctcgctt 1176001 gtaatgtcgg cgctgaccct tttgttttca ttttctccag tcccattttt atgcgctctg 1176061 gcttgtgctg caatggggcc tttttatcag gtgcgtgata tttgccagga aaccatgctg 1176121 caggaagtta ttcccgagca gaaacgaatc ggaatcatgg ctgcaaaaaa tgcgattttg 1176181 actccttggt caggcgtcac ctactccatt atggggctag tggctgatgc tgctggtgcg 1176241 aaaatagctt ttatcgcggc tgctgcatta tatatcatga catttctgat tgcactggcg 1176301 cagccccgtc tggttcatta caggcgagaa aatcgagttc aatgagaaac acttcaaaat 1176361 gaacggagca gctggctccg ttttgctgaa aaaaaaatga aaccatggcg gaagttcgca 1176421 cgtctttata gatgtaaggc tgtttaaaca agaagaaatg gggtatatct aaaagtatga 1176481 agacaacgaa ctcataagga gcaaatcaat gaactggtat gaaaagctta gcgagtactt 1176541 tccaattgaa gaaatgaaat caaaagcgca tatggaagct cttctgaaag agcgaagcga 1176601 tatttatcat aaagatgaag gcaaacatca tattttaatg tttgcggaat tcgattcttt 1176661 tatcttcgtt gattatctgt atgtgtctaa ggatgcaaga gggcaggggc ttggcggcaa 1176721 attgatcgcg aagctgaaaa agaaaaataa gcccatattg ctcgaggtgg aacctgtgga 1176781 tgaagatgat actgatacag aaaaacgcct gaggttttat caaagagagc atttcaagca 1176841 tgctcagtca attgggtacc ggcgccggtc attggctacg aatgaagtaa acaagatgga 1176901 gattctgtac tggtcaccaa aaacagaatc agaagaagaa attcttgaag ccatgaaaca 1176961 gacatatgaa aacattcata cttataaaga tgagaaatgg tacggagaat cgtacgaaaa 1177021 aacggatgag gtcttggaaa tcatcgatga agaaaaacaa aaaaatattt tcgatcagtt 1177081 aagctaattg agaataagaa catatcatga acattaaaaa tttgctggat tgacacattt 1177141 ttttcttagg atactgttca cacttacttt tttatagtat aatacctgta aagattcctt 1177201 ttttagagta atttcaattt aagaataaaa tagatgttca tcctactaat tagaggagtg 1177261 aagatgaatg gttacactat acacatcacc aagctgtact tcatgcagaa aggcgagagc 1177321 gtggctcgag gagcacgaga ttccatttgt agaaagaaac attttctctg aacctttatc 1177381 aattgatgaa ataaaacaaa ttcttcgaat gactgaggac ggaacagatg aaatcatctc 1177441 aacccgttca aaagtattcc aaaaactgaa tgtgaacgtt gaatctatgc cgctgcaaga 1177501 tttgtaccgc ttgatcaacg agcatccagg tttgcttcgc cgtccgatca tcattgacga 1177561 aaaacgtttg caggtcggat ataacgaaga cgaaatcaga cgtttcctgc caagaaaagt 1177621 tcgctctttc caattaagag aagcacagcg tttggcaaac taatagatcg tatcatcaaa 1177681 agaaggctga gtcatcagcc ttcttttatt tttcaacctg ctggtaataa atgctcgcaa 1177741 ggatgacaaa cgcaaccgtc aaaatgggga ggagcgtttc gactgtgccg tgctgcgcca 1177801 taaaaagcga cagctttttg tctctgacaa tcatttctcc gccagtataa gcaagcagcc 1177861 cgcttcccgc gtaaatcaga agcggtattt tctctagtgc aatatggatg agtttgctgc 1177921 cccaaataat aaccggaacc gatacacaca atcctataac aacgagagaa aactcaccgt 1177981 gtgaagctcc cgcaactgcg atgacgttgt ccagcgacat aaagagatct gcaagcacaa 1178041 tcgttcgtat cgctctccac agggaggtgc tgcttttaat gtgtttcgtg tctttttttt 1178101 caatcagcag ctgatatcct aaatacagca ggaaaattcc gccggcgcac tgcaagaacg 1178161 gaatgttcaa aagatatact gctgcacttg ttaatccgat tctcatggca acggcaataa 1178221 atgttccgag aataatggct tgctgtcttt gcttgtccgg caaatgtctg ctggccatgg 1178281 caataacaac cgcgttatct ccgccgagga tcaggtcaat cccaacaatg acgagcagag 1178341 aaatcagata gtcatgctcc atgaagcggc acctcgcttt cagtccttcg cttgtactac 1178401 tactatatga gacaggtcat attttatgat atcagccgcc tgatctgccg ttttttaggc 1178461 aaaggtgcat ttttatttct tttgtgactg ttttatcata aaatagaaat acaaaggaat 1178521 tcacactggc cttggttaag gttaagatgt ggacggaatg ggtaaagtgt agtaaagtac 1178581 aattaatcgg gagcttagat gtcccttcaa catcttatat agaagggaag gttggcaaat 1178641 ggaaattgaa agaattaacg agcatacagt aaaattttat atgtcttacg gagatattga 1178701 agatcgcggt tttgacagag aagaaatttg gtataaccgt gagcgcagtg aagaactttt 1178761 ctgggaagtc atggatgaag ttcatgaaga agaggaattc gctgtggaag gcccactttg 1178821 gattcaagtt caggcactgg acaaaggatt agaaatcatc gtcacaaaag cccagctttc 1178881 caaagacgga caaaagctcg aactgccgat tcctgaggat aaaaagcaag aaccagcatc 1178941 tgaggatctt gacgccttgc tggatgattt ccagaaagaa gagcaagccg tcaatcagga 1179001 agagaaggag caaaagcttc aatttgtctt gcgatttggc gattttgagg atgttatttc 1179061 tctatctaaa ttgaacgtta acggaagcaa aacgacttta tattcgtttg agaaccgata 1179121 ttatttatat gtagattttt gcaatatgac tgatgaagag gttgaaaatc agctaagcat 1179181 cctgctggag tacgcaactg aatcctcaat cagcatacac cgtcttgaag agtacggcaa 1179241 gctgattatt tcagagcatg ctctagaaac gataaaaaaa cactttgcat catagcaaac 1179301 cgatttcctt ccggaaatcg gtttttttta tgcacgaaaa tgccatttta gagatgtgaa 1179361 aaatcaaaaa catatagaca agcagaaaat acagcgaaca ggagttgatc atcttttcca 1179421 gaaagtatac ttcatctgga aaggagagat gacaattgtt tagtgctgtg actgaagacg 1179481 gccaaatgtt tcaccttcta ggcgctcagc aaaaccagaa attaaagcgg agacggttct 1179541 tctgtccggt atgcggggga gagctagctg tgaagctcgg acttcaaaaa gcgccgcatt 1179601 ttgcccataa acagaacaag tcctgcgcca tagacatcga gccggaaagc gcctaccact 1179661 tagaaggaaa aagacagctg tatgtatggc tgaaaacgca acgggcttca ccaatattgg 1179721 agccgtatat aaggacaatc aaccaaagac cggacgtcat ggcaagaatc aaggagcata 1179781 tgcttgctgt tgaatatcaa tgcgccacta tcgctccaga tgtctttcaa aagcggacag 1179841 agggcttcaa acaagaagga atcatcccgc agtggattat gggatacagc cgcttaaaac 1179901 ggactgcttc gtccttttat cagctttcaa cttttcattg gcagtttatc aatgcaagtc 1179961 catacagaga actgatatgt tattgtcctg aaaggcgttc ttttctccgg ctcagccaca 1180021 tcattccatt ctacacaaac cattcttatt cctcagtcca aacgatccct atccatcggg 1180081 caggtgcagg cgatcttttt ttcactgaac cgaaaccctc aattcaatat tcaggctgga 1180141 cgaaagcgat tcaccgtttt cgccataaac cccatcggtt taactcaaag gaaacaaatc 1180201 gccttaggct gctgttttat gagaaacgac agacgccttt ttcttttctg ccgactgaag 1180261 tgtttgttcc tgttagaaaa ggggcagttt ttaagagtcc ggtttttgtg tggcaggggt 1180321 ttctttattt gtttatgacg gatcttggag gtaaacgtgc gccaattcgt ttttcagccg 1180381 ttttgcagca gtgcaaactg cacattcata ataagaacat tgcactcagg tccgaatgca 1180441 gcgaagagtg tctttcagaa gcggttaaac agtatattga ttttttgtgc aagaagggat 1180501 ttttaaggga gactcagaaa gaagtatatg tgctgaatca gcctgcagga ggcatacact 1180561 ccatgcagga tctcatagaa agagaccgca gctgttttat agaatgagtt tgtcttattt 1180621 ggctcaccct aagacaaagg tggtgggcag gctgtgaaag gcacaaaagg aaaggttttt 1180681 cgtgttttta ctgctttttt ggcattcgtt ctcttcatta ctgcatatga tttgacaaaa 1180741 ggcagtgaaa aaccggaaga tattcacaac acaagtttat tgagaaacag ctgttttttc 1180801 aattggcttg aatcaaagaa gacgaggggg atcaccatgg ctgaggaaaa aaaagcaaac 1180861 caactgcctg acagaagtga ggtaaaggca gaagacacat ggagacttga ggatattttt 1180921 cctagtgatg aggcctggaa taaagaattt caagctgtaa aagaattaat tccgaattta 1180981 tctaagtata aaggaaagct ggcagattca gctgatcatt tatacgaggc tcttacgtat 1181041 caagataaag tgatggagcg gctaggtagg ctgtacacat atgcgcatat gcgctctgac 1181101 caggatactg ggaactcctt ttaccagggg ctgaatgaca aggcgggaaa cctgtataca 1181161 caggccgcaa gcgcgacagc ttatttggtt ccggagattt tatccataga agaagacaaa 1181221 ctgcagcagt tcattcttga aaaagaagaa ttgaagctgt actctcatgc gattgaggag 1181281 attacaaagg aacgtccgca tgtgctgagc gagaaggaag aggcgctgct tgctgaagcc 1181341 tccgaggtac tggggtcatc ttcaaataca ttcagcgtgt taaataacgc agatataacg 1181401 tttccatcca ttaaagacga agatgggaat gaaaaacaga tcactcacgg caactttatt 1181461 aatttcttgg aaagtgaaaa ccgtgaagtc cgcaaaaatg cgtttgacgc agtgtataaa 1181521 acgtacggac aatataaaaa cacaatggcc acgacgctaa gcggcactgt gaaaaaggac 1181581 aacttctacg cgagagtgaa aaagtacaag tccgcgcgtg aggctgcgct ttctaacaac 1181641 agtattcctg aggaagtata cgataacctt gttaagacga ttaataagca tttgccgctc 1181701 ctgcaccgct atattgcgct aagaaagaaa gtgcttgagc ttgatgaagt gcatatctat 1181761 gacctgtata caccgcttgt gaaagatgct gggatgaagg tgacatacga ggaagccaaa 1181821 gattacatgc tgaaaggcct cgcaccttta ggggaagaat atgcctctat cctaaaagaa 1181881 ggactggaaa accgctgggt ggacgtttac gaaaataaag gcaaacgcaa tggggcttat 1181941 tcatcaggag cttacggcac gaatccgtat attttgatga actggcataa taacgtcaat 1182001 aatctcttta cgctcgtgca cgagtttgga cattccgtac acagctacta tacgagaaag 1182061 caccagcctt atccatacgg caattacagc atctttgtcg cggaagttgc ctctacgaca 1182121 aatgaagcgc tccttggcga atatttgctg aacaatttag aggatgaaaa acagcgctta 1182181 tatattctca accatatgct tgagggcttc aggggaacgg tcttcagaca aacgatgttc 1182241 gctgaatttg aacatctgat tcatacaaag gcgcaagaag gcgagccgct tacacctgag 1182301 cttctgacaa atgtctatta cgacctgaat aaaaagtatt ttggagacgg catggtgatt 1182361 gataaggaaa tcggccttga atggtcgcgt attccgcact tctattacaa ttactatgtg 1182421 tatcagtatg cgacaggtta cagcgctgcc caagcattaa gcagccagat tttgaaggaa 1182481 ggaaagccgg cggttgaccg ttatattgac ttcctgaaag cgggaagctc acaatacccg 1182541 attgatgtcc tgaaaaaagc gggtgttgat atgacgtctc cagagccaat cgaagccgcg 1182601 tgcaaaatgt ttgaagaaaa acttgatgaa atggaagagc tgctgatgaa agtcaagcag 1182661 tcttaaaaaa gtaagcctgt gcggaaatga cgcacaggct tttttaaaac cctttaaagg 1182721 ttttccggtg attcaagcgg tagagggtaa acaaaataga cagaaacagc agaggagagg 1182781 taatataaag cggcagcata tgcatcatgc ctaagatatt caagcagaaa aaaacagcaa 1182841 tgcacacaat tgagatcaaa gtagacatca tggcggtcct cctcgtcctt tttccttata 1182901 aggatatgag tgaatgcact tcgttatgtt ttgtgacaaa aatatgaaca ttaagcatag 1182961 aggttgtcaa aagtcgacat cttttgttat cataaggatg tgaaattgat cacaaacaaa 1183021 cattacccct ttgtttgacc gtgaaaaatt tctcccatcc cctttgttgt cgttaagaca 1183081 tatgaaaccg cgcttatccc ggcgcggttt ctttagtgct aaaaatggaa cgtacgtttg 1183141 gttatggcat aaaaaaacag cctcaagcat atgcacgcct gcggctattt ttcacatgat 1183201 tgatattcat cagaataagt gctgagagac ttccaaaaca ttccgtgttt ggcttccact 1183261 ttggcaacct ttttagcaaa cgccagtttt ttcatttctt tttctacctc ttcaaggctc 1183321 aggtcatata caagagcaat ttccttcgag gcaacgaagc ggaaatattc aataaaacat 1183381 tctaaaggcg gtgtttccga cggcttcggc tcgtcgccaa gcatctcaaa taaaatttct 1183441 tcatatacat catatgagta gctgccagga actttaagcc cttcatcctc atgctgcgta 1183501 ttaaaaaacg tcagtgtcgg attaacagaa acatccatct cggcagcaat tttcatgtca 1183561 cattgaagcg ccttgaccgc gctttgagaa tgcagatctt ttttgaattc ttcaagatcg 1183621 agacttgtat tttcagcaat ctccaaaagc acgttttcat ccgtaatatt tttctttgaa 1183681 acaaataggc tctcctgcat atttctgaga aattgcatgc cggcttttcg tccttgcagt 1183741 tcggctgctt taaaagcgag agcagccata taaggcgatg aaagcggctg atcctgttcg 1183801 aaccagacat tgccgtcaca tgacatgcca gagcggctcg cgatcttttc ccatgcttct 1183861 gcgagaagat gcttttttcg ctttttattt aaagcggtaa ggcttgcgga agcgataatg 1183921 cgtaaggtga aaaaacgtcc gtatctgatt ttcagctttt tgatgacggg ctctaaggac 1183981 cagcattcag gacataaagg gtctacaaac atataaattt caagcggttt ttttggatga 1184041 ccgtggcaat gggcgaagta tagctcatgc tgatagtttg tcaagatgat cgatcctccg 1184101 cttccgtttg attcaccata tgccttgctg tcaactccag ccggccaaac aaaaactcac 1184161 gaatttcgcc ctccagccct acatggtcca ttgcgtcctt catacagctg agccacgcat 1184221 cagctctctc gtttgtaatt ggaaagggaa gatgccttgc tctgagcata ggatggccgt 1184281 gttcctcagt ataaagagga ggcccgccta aatactgagt taagaattgc ttctgtttcc 1184341 tggcggtttc tgtcaaatcg cttggaaaaa tcggcttcag caaaggatga gacgcgacac 1184401 gctcataaaa agtatcaaca agttgcgata gaagttcctc tccaatcgct tcataaggtg 1184461 cgttaaacga ttgtcccatg ttgactactc ctttaaatat ggctaatagg aatcataaat 1184521 cctattgcaa aaagtaattt tctgtatttc attgtttcat ctagatttat tttagcaaca 1184581 aggcatcatt tctacaaaca aactgccttt tatgcgtttg atgactcatt tcggctgaca 1184641 gccggggttt gtatttcata tcatatcaca taaaaatcag gaatgcgtaa gatttcactt 1184701 cgcaaaaaaa ccagagggaa agagcacctc tggttacgcg taataaactg aagttatttt 1184761 ttttacatag ttttgcgttt cttggaaagg aggaatgcct ccgtatcggt caacattccc 1184821 cggtccggcg ttgtaagccg ctaatgccat agacacattg ccgtcgtatt tatccagcat 1184881 ttgttttaaa tatttcgttc cgccctccac attttgctgc ggatcaagcg gattggaaac 1184941 gccaagtgag cttgctgttg acggcatcag ctgcatgagg cccatcgcac ctgctccgct 1185001 gaccgctttt gcattaaagc ctgattcctg tttgatgacg gcgcggatca gtttttcatc 1185061 aacgccatat ttatcagcgg cttttttaat cgcactgtca atagagaagt ctcccgaacg 1185121 gatctgattt gcttcatgtt tgtttgaagc tgaatctgca acagctgttt cagtgctttc 1185181 tgccgctttt gtgactgaac ctgaattgct gctcgtatat gagttaagcc catacgctga 1185241 aagcagtgac ggcgctgttg tattcgcgct gttcagcatg ctgagcgggc ttggcgatga 1185301 agaaggtgct gattgctgag atgtcagacc gtttgtatat tggctgagca aagaactgaa 1185361 acttgaaagc gggctttccg tattctgagt gtccgagctg ctgcgtgcat tagatatgga 1185421 ctgtaatgcc tgaagctgaa gtaatgctgc ccaattcgtt acattcacga tgtcattcca 1185481 ccttatatag actttcgttt ttcttcataa aaacgcagaa ttttattttt ggtttcgcgc 1185541 tgaggaatgc tgaattgctg aagcagcttt tcgaaggctt gtctgccctc atgccaatcc 1185601 gccgcctcaa attcaatttc atagtcctct ttatttaaat atcggctgtg gtctaaaact 1185661 attaagcctt tttctgtttc tttttccgca cggtttgttg ctaaagatcc aaagtattgt 1185721 atggcatccg tatcgatctg aagcttgtgc agctggtcct tcacagggcc ctcgggaact 1185781 gaaaatccag cgagatctga tacctctgaa agctgctggt gcgtttccag aagccccaca 1185841 tcagccggct cctttaatgt aaggacatac tttccgtttt ttctgcggat acgaagcgca 1185901 gcatgttttt gtttcagcgc gaagctgtct gtatcaaaat aatgattctt ttgatctgta 1185961 aaatcttttt ctgtcagctg gagtgccgat gctatgtttt tgaattcttg tttggtcagc 1186021 atgtttttaa attcgatttc aatctcttgg ctcatgatgc tcttcctttc cgccctgtaa 1186081 atcttatttt tactattatc tctttagatg ttaggtttat caatatcgag ctcgatatga 1186141 taaaatgaat ctgtactttg tttaaaaaag gagagcatta tgcaaaacag aatcgaaatt 1186201 ttgaatgcaa cattatcgga tgatcagctt cgccttgcct gtcagacaga aggaaacgaa 1186261 gcggaacgca agccgtcagg tcaaatgctt gttgattctg accactttgc ttttgtatac 1186321 atacttgaat tagctgattc ttttgaatat gtcattataa aggaacatgt atggccggaa 1186381 ctgaagcagg cccatgcaca aaaaataccg gttgttttag aggcaggaga ccaaacaatt 1186441 gaactggcag gcctgcatga ggagctggaa tatcttttag aaaatataaa agataatgca 1186501 aactatggag aagaaatgga agaaaaagtg aaacgcgtgt ttttatagaa actggttcgg 1186561 aattggggga tgtatgatgg atgacaaaca atgggagcgt tttttagtgc cgtaccgcca 1186621 ggctgtcgaa gagttgaaag tgaagctcaa ggggatccgc acactatatg aatacgagga 1186681 cgaccattca ccgatcgaat ttgtgaccgg acgcgtcaag cctgtggcga gcatacttga 1186741 aaaagcgaga cggaaaagca taccgctgca tgaaattgaa accatgcagg acattgctgg 1186801 ccttagaatc atgtgccaat ttgtcgatga catccaaatc gtaaaagaga tgctttttgc 1186861 cagaaaagat ttcaccgttg tggatcagag ggattatatt gcggaacata aagagagcgg 1186921 ataccgatca taccatcttg ttgtgctgta ccctttgcag acggtatccg gagaaaagca 1186981 tgttctcgta gaaatacaga tccgtacact ggcgatgaat ttttgggcga ccattgaaca 1187041 ttcattgaat tataaataca gcggaaacat tcctgaaaaa gtaaaactaa ggcttcagcg 1187101 cgcttctgaa gcggcttccc ggcttgatga agagatgtcg gagatcaggg gtgaagtaca 1187161 ggaagctcaa gctgcctttt caagaaagaa aaaaggaagc gagcaacaat aggtaaaggg 1187221 gaagaagagc atgaaatttg ccgtatcatc aaaaggagat caagtttctg atacgctgaa 1187281 aagcaaaata caggcgtatt tattggattt tgatatggaa ctggatgaaa atgaaccgga 1187341 aatcgttatt tcagtcggag gcgacggaac gcttttgtat gcttttcaca gatacagcga 1187401 ccgtttggac aaaacagcat ttgtcggcgt tcacacaggt catctgggtt tttatgccga 1187461 ctgggttcct catgaaattg aaaaacttgt tcttgccatc gcgaaaacgc cgtatcatac 1187521 agtcgaatat ccgcttctcg aagtcattgt gacctatcac gaaaacgagc gggaagaaag 1187581 atacttagct ttgaatgaat gtacgattaa aagcatcgaa ggaagccttg ttgctgatgt 1187641 ggaaatcaaa gggcagctct ttgaaacctt ccggggcgac ggcctctgcc tgtcaactcc 1187701 atcaggcagc acagcctaca ataaggcgct gggcggagcg attatccatc cgtctatcag 1187761 ggcgatccag cttgcggaaa tggcttcaat taataaccgc gtgttccgta cggtcgggtc 1187821 acctctgctt ctcccatccc atcatgattg catgattaag ccgagaaacg aagttgactt 1187881 tcaagtgacg attgaccatt taacccttct ccataaggat gtaaagtcga tccgctgcca 1187941 agttgcatcc gaaaaagtgc ggtttgcgag attccgtccg tttccatttt ggaaaagagt 1188001 ccaggattcg tttattggaa aaggtgaata gaaagaggac atatcgtgga gcattttttt 1188061 atcagaaaga acattacttc cgctgaggac gggatgactg taaaagaata tgccggtgaa 1188121 ctgggaattt cgaaacgtct gctgaccgat attaagtttg gcgggggaga cctgcagatt 1188181 aacggtgagc atgtgacggt caaatacgtt ttgaaagagg gagatcttct tatcgtgaag 1188241 tttcctgagg agcaggtgag cgagacgctg ttggcagagc ctgttccgct cgatatcctt 1188301 tatgaggatg aacatgtgct tgtgataaac aagcagccgt atgtgtcatc aatcccttcg 1188361 agagagcacc cctccggcag cattgccaat ggaattattg atcattatca aacaaccgga 1188421 gtgagggcga cagttcatct tgtcacccgg ttagaccggg atacatcagg tatcatgctt 1188481 gttgccaagc atcgatttgc ccactccatt ttatcgtctg cgcaaaaaaa cggccttgtg 1188541 aaacgccggt atgcggcagt ggttcacggg cggatggcac agatggaggg aacagtcgat 1188601 gctccgattg gcagacatcc tgacagtatt attgaacgga cggtaacgcc agacggccag 1188661 aaggctgtta ctcattttta cgtcacatgt gcaaatgatg acatgacctc ggtggcattg 1188721 cagcttgaga ctggacgaac ccatcaaatt cgtgttcata tgagctatct cgggcacccg 1188781 ttgtgcggcg atacactgta cggcggaacg agacaggaaa ttggccggca ggctctgcac 1188841 agcgagcatc tttcgtttat ccatccgctg acacaggaga acatgaggtt tcatgctcca 1188901 ctgcctcagg acatgagcaa actgataaaa ggagagaatc attgattctc tcctttttta 1188961 tatggggcga aatcttgatt cgtcgtaagg cagggagctt ggaacagaga cggtttctat 1189021 ttctggaaag cgaaagcctg tcagttgatt tccgaacacg cagcctgtat caatgttgat 1189081 ggtgcgattg accttccgag gctctttcac aggtgtatga ccgtatacca cccaagcctt 1189141 tccgttatag gctgccgccc aatcacgcct gatgggtctg ccgtccggat atgtttcacc 1189201 cgtcacgtca ccgtaaagca caaagtcctt cactctgcgg gtatatttgc cgatatcgtc 1189261 agctcttatg ccagcatggg cgacaactaa ttctccatta tgtaagatgt cgtaaagcgg 1189321 cgctgtttcg tacagcttca taaactgttc gctgactgat tttttctcat ctttggaaag 1189381 ttcctcaagc tctgccgctg ttgtttcgag accatgcatc acttttaccg gatttccttt 1189441 taagtaacga tataatttat tgcaatggtt tcccgggaca taacgcacag cgcctttttc 1189501 gtaagcgccg gctacaaatc ggatgacctc tatcgatttg ggccctctgt cagttaaatc 1189561 tccggcaaaa acaagcaccc tgccttcttc atggacaggt actccatttt tgattgtata 1189621 gccaagcttt tggattaatg cagtcatttc gtcatagcag ccatgaatat cgctgatgat 1189681 atcgtaagcc atgcggtctc ctccttaccg attgttttat ttattatgaa gcaaagtgtt 1189741 gtgagtcatc acaagctttt atgtgcaaat tatagaagaa gaatcatttt ctaaacagga 1189801 ttaagacctt atcactttat ttttcatcat cacccttgtt aaaatcgcgt tatgtttttt 1189861 aaaaatgagg ttttgttctc tgagtgagaa ctagcataac cctgacttaa aaaggaggtt 1189921 ctgattatgg cgcatacatc tgtcgcatct ttagttgttg tacttatcgt tgcatttttg 1189981 acacccatcc ttttgcatcg gtttaaactc agcatcccgg ttgttgttgc tgaaatcatt 1190041 atggggctga taattgggaa aagcggcctt aatttagttg tggagggtga cacctggctc 1190101 cagacactct ctatgctcgg atttatcttt ttaatgtttt taagcgggct tgaaattgat 1190161 ttttcgtcgt ttgagaaagg aaagaaaaag cagttcctgc cgaatggcaa ggaagcgccg 1190221 aatacgtttg ctgcggcatc tgttattttc gtcggtattt ttattttatc attgctcttg 1190281 tcctatgggt tcgtcttggc cggatttatc caaaatgcat ttttgatgac cctgattatt 1190341 tcaacgattt cattaggcgt tgtcgttcca acattaaaag aagaacggat catgaattcg 1190401 aatatcgggc agattatttt gcttgttgct gttattgctg atttggccac gatgattctt 1190461 cttgctgttt tttcttcttt atacggagag gacagcggaa acatgtggct cctgatgatt 1190521 ctgtttgcgg ccggagtggt gctttacttt ttcggccggg tcttcaaaca tcgctctttt 1190581 gttcaatcca tgtcaaaagg gacgatccag atcgggacgc gtgccatttt tacgttaatc 1190641 attgtactcg ttgccctgtc tgaatcactt ggggcggaaa atattctcgg cgctttctta 1190701 gcgggggttc ttgtttccct gctttcgcca aacaaagaac ttgttcagca gctggactca 1190761 ttcggttatg ggttcttaat accgattttc ttcgtgatgg tcggtgtgaa gcttgatatt 1190821 tggactcttt tccaggataa aacaatttta atcatgattc cgctcctgct gcttgcgctg 1190881 ttagtcagca aaatcattcc tgtcatgtac ttaaagaagt ggtatgataa ccgaaccatt 1190941 ttcgcgtctg gtttcctgct gacatcaacg ctttcgctcg tgattgctgc tgcaacaatc 1191001 ggccagcagc ttcacgtgat cagtacaaat atgtcaggag cgctaatttt agtagccgtc 1191061 attgcaagta tttttacgcc gatctgtttt aaaaaattat acaaacggga agagcagccg 1191121 gaggagaaaa agacgattac gttcattggc gccaatcaaa tgactttgcc tgtcacactc 1191181 gaattgccag aggaagagta tgacgtgcgt gttgtacacg tctaccaaga gaatgcggag 1191241 gaaaagctgt cagaatcagt gtttgctgtt gaaacaattt ctgactatga acacgagacg 1191301 cttgaatcac tcggcatttt tgaaacggat atcctcgttg tggcgacagg aaatgaagat 1191361 atgaatgcag acattgcatt acttgcaaaa gataaaggca cagaaagagt cattgcaagc 1191421 gtaggatcac cggagcatga agcagctctg aaggagcagg gaatcagcat cttttctatt 1191481 ctgctgtcga caaaaacgct gcttcgcgca ctgattgaag cgcctggcgt catgaagctg 1191541 ctcacgaacc aagagtcttc gctgtatcaa attaatatgg agaacagtaa atatgatggt 1191601 gtcattttac gggaattccc tttaacaggt gacgtcatct ttgtcaggat cttcagaggt 1191661 gtggacagca tcgttcctca tggggatacg aggctgaaac ttggagaccg tttaattgtc 1191721 accggatctc gggggtacgt aacggatctt aagaaaacat tggaaggata aatcttgacc 1191781 aaataaggat tcgtgttaat atagaggtgc agaacaattc aatatgtatt cgtttaacca 1191841 ctaggggtgt ccttcataag ggctgagata aaagtgtgac ttttagaccc tcataacttg 1191901 aacaggttca gacctgcgta gggaagtgga gcggtatttg tgttatttta ctatgccaat 1191961 tccaaaccac ttttccttgc gggaaagtgg tttttttatt ttcagagggg gaatgatttg 1192021 tgaagttttc agaagaatgc cgcagtgcag ccgcagaatg gtgggagggg agctttgtcc 1192081 atccgttcgt tcaaggaatc ggtgacggaa cgcttccgat tgaccgtttt aaatactacg 1192141 tacttcagga ttcctattat ttaacgcatt ttgcaaaggt gcagtcattt ggtgccgctt 1192201 atgcgaagga tctttataca acggggcgga tggcaagcca tgcccaaggt acatatgagg 1192261 cggaaatggc gcttcatcgc gagtttgccg agctgttgga aatcagcgag gaagagcgta 1192321 aggcgtttaa gccgtctcct acggcgtact cttatacatc ccatatgtac cgttcggttt 1192381 tgagcgggaa tttcgcagaa atcttagcgg ccctgctgcc atgctattgg ctctattacg 1192441 aggttggtga gaaattgctg cattgtgatc cggggcatcc aatttatcag aagtggattg 1192501 gcacatatgg cggtgattgg tttagacaac aggtcgagga gcaaatcaac cgctttgatg 1192561 agctggcgga aaacagcacg gaggaagtgc gtgccaagat gaaagagaat tttgtcatct 1192621 ccagctacta tgaatatcaa ttttggggaa tggcctatcg aaaagaaggc tggtctgaca 1192681 gcgccataaa agaggtggag gaatgtggag cttcacgcca taacggatga cagcaagccg 1192741 gtagaagagc tagcgagaat catcattacg attcagaatg aagttgattt tattcacatt 1192801 cgggaacgct caaaatcggc ggcggatatt ttgaaactgc tcgatcttat ttttgaaggc 1192861 ggtatagata aacgaaaatt ggtgatgaac gggcgcgtgg atattgcact tttctctact 1192921 attcaccgcg tgcagctgcc aagcggcagc ttttcaccga agcagatcag agccagattt 1192981 ccacaccttc atatcgggag gtcggtgcat tcactggagg aagcggttca agcagaaaag 1193041 gaagacgcgg actacgtgct gttcggccat gtgtttgaaa cggattgcaa aaagggtctt 1193101 gaaggcagag gagtatcttt gctgtcagat atcaaacagc ggatttccat cccggttata 1193161 gccatcgggg ggatgacgcc ggacaggtta agagacgtaa aacaagcagg ggcagacggc 1193221 attgctgtta tgtcaggaat tttctcttcc gctgaacctt tggaagcagc cagacgatat 1193281 tcccgcaagc taaaggagat gcgctatgaa aaggcattat gaagcagtgg tgattggagg 1193341 cggaattatc ggttccgcaa ttgcttatta tttggcaaag gaaaacaaaa acaccgcatt 1193401 gtttgaaagc ggaacaatgg gcggcagaac gacaagtgcc gctgccggaa tgctgggcgc 1193461 ccatgccgaa tgcgaggaac gtgacgcgtt ttttgatttc gctatgcaca gtcagcgtct 1193521 gtacaaaggt cttggagaag agctttatgc attatccggt gtggatatca ggcagcataa 1193581 cggcggtatg tttaagcttg cattttctga agaagatgtg ctgcagctga gacagatgga 1193641 cgatttggac tctgtcagct ggtattcaaa agaagaggtg ttagaaaaag agccgtatgc 1193701 gtctggtgac atctttggtg catcttttat tcaggatgat gtgcatgtgg agccttattt 1193761 tgtttgcaag gcatatgtga aagcagcaaa aatgcttggg gcggagattt ttgagcatac 1193821 gcccgtcctg catgtcgaac gtgacggtga agccctgttc atcaagaccc ctagcggaga 1193881 cgtatgggct aatcatgttg tcgttgccag cggggtgtgg agcggaatgt tttttaaaca 1193941 gcttggactg aacaatgctt ttctccctgt aaaaggggag tgcctgtccg tttggaatga 1194001 tgatatcccg ctgacaaaaa cgctttacca tgatcactgc tatatcgtac cgagaaaaag 1194061 cggaagactg gttgtcggcg cgacaatgaa gccgggggac tggagtgaaa caccggatct 1194121 tggcggattg gaatctgtta tgaaaaaagc aaaaacgatg ctgccggcta tacagaatat 1194181 gaaggtggat cgtttttggg cgggactccg tccgggaaca aaggatggaa aaccgtacat 1194241 cggcagacat cctgaggaca gccgtatttt atttgcggct ggccatttca gaaacgggat 1194301 cctgcttgct cccgcaacgg gcgctttgat cagtgatctc atcatgaata aagaggtcaa 1194361 ccaagactgg ctgcacgcat tccgaattga tcgcaaggag gcggttcaga tatgatgcta 1194421 cagctgaacg gtaaagacgt gaagtggaaa aaagacacag gtacaattca agacctgctg 1194481 gcgtcgtatc agcttgaaaa taaaatcgtt atcgtggaaa gaaataaaga aataatcggg 1194541 aaagaacgct atcacgaggt tgagctttgt gatcgtgatg tcattgaaat tgtccatttt 1194601 gtaggaggcg gatgagcatg ttaacaattg gcggaaaatc atttcaatca agattgctgc 1194661 tgggcacggg gaaataccca tcgtttgaca ttcaaaagga agcagtagct gtttctgagt 1194721 ctgatatttt aacatttgct gtaaggagaa tgaacatttt tgaagcatct cagccgaatt 1194781 ttctggaaca gcttgattta tccaaatata cgcttttgcc gaatacagcg ggcgccagta 1194841 ctgctgaaga agcggttcgg attgcaaggc tggcgaaagc ttcaggcctt tgtgacatga 1194901 ttaaagttga agtcatcgga tgcagccgtt ccttgctgcc tgaccctgtt gagacattaa 1194961 aagcgtctga acagcttctt gaagaaggct ttattgtgct cccgtacacg tcggatgacg 1195021 ttgtgctggc gagaaagctg gaagagctcg gcgttcatgc catcatgccg ggtgcatctc 1195081 cgattggatc aggacaagga atcttaaatc ctttgaatct gtcgtttatt attgaacagg 1195141 cgaaagtacc ggtcatcgtg gatgcgggaa tcggctcgcc taaagatgcg gcatacgcaa 1195201 tggagcttgg agcggatggc gtactgctca atacggctgt atctggcgct gacgatcccg 1195261 tgaaaatggc tcgtgccatg aagctcgcag tggaagcagg gcgcctttct tatgaggcgg 1195321 gccgaatccc gcttaagcaa tacggaacgg caagcagtcc gggagaaggt cttcctgtat 1195381 gacaggcagg tattcaaggc aggagctgtt tgctccgatc ggcccatccg gccagaaaaa 1195441 attgaaagaa gcgcgcgccg tgattatcgg cgccggcgcg ctcggaacag ccagtgcaga 1195501 aatgctggtg agagcgggag tcggctctgt gaaaattgcc gacagagatt atgttgaatg 1195561 gagcaacctc cagcgccagc agctttatac agaagatgat gtcaaaaaag aaatgccgaa 1195621 agcagccgct gcggagcgcc gtctccgttc gattaacagc gatgttgatg tgaccggcct 1195681 tgtcatggat gtgacagcag aaaatatctt cgagctgatt agggatgcat cgattattgt 1195741 ggatgcggct gataattttg aaacccgcct gatcgtaaat gatgctgcgg taaaggaagg 1195801 gattcctttt ctttacggtg cctgtgtagg gagctacggt cttaccttta ccgtggtgcc 1195861 gggttctact ccttgcctgc attgcttgct cgatgcactt ccgattggcg gagcaacatg 1195921 tgacacagct ggcatcatca gtccggctgt tttgcaggta gcagtctttc aggtaacaga 1195981 tgcactgaaa ctgctgacgg gagaggagtg cgagccggtg ctgcgctcct ttgatttgtg 1196041 gaaaaacgag cggtcagaag tgagagcggc cagtctcaaa catgacgcat gcccaagctg 1196101 cggcacaaag gattttccgt ttttgtctta tgaaaatcaa acaaaagcgg ctgtattgtg 1196161 cggcaggaac acggtgcaga tcagatcatc tattacgaaa gaagcggatc ttgaagcgct 1196221 tgccggtcag ctgaggcagg ccgggcttga agtagctgcg aacccgtatt taatttcctg 1196281 ccgctcggat gatatgaaaa tggtgctgtt ccgggacggc agagctttga tccatggaac 1196341 aaatgatatt gcccgggcaa aatccattta tcataaatgg attgggtaat aaaaggagtg 1196401 tagtgtaatg agtatatata aagcattgac aatcgccgga tcagattcag gcggcggcgc 1196461 agggatacag gctgatatta aaacctttca agagcttgat gtattcggaa tgtctgcgat 1196521 tacggcggta accgctcaaa atacgcttgg cgttcacggg gtgcatccgc tgactgtaga 1196581 gacgttgaga cagcaaattg acgctgttgc tgaggatttg agaccggatg cagttaagac 1196641 gggaatgctc tggaatgccg acatgattga agaagtggca agaaaaattg acgagtacgg 1196701 attcaatcgt gtaattgttg atccggttat gatcgcaaag ggcggggcat ccttgctgcg 1196761 tgatgagtca gttgccacct taaaggagtt gctcattcca agaagctacg cgattacgcc 1196821 gaatgtcccg gaagcagaaa cgctgacagg aatgacaatc agctcgctgg atgaccggaa 1196881 aaaagcagcg gagcagctcg tcaagatggg tgcgcagcat gtcattatca aaggcgggca 1196941 ccagcctgag gacaatcaca ttactgacct tctttttgat ggcagcatgt ttatgcaaat 1197001 cacccatcct tatatcaata cgaagcatac gcatggcaca ggctgcacct ttgctgcggc 1197061 tttaacggcc caaacggcta aaggagacag catccatcag gcatttgagg ttgcggccaa 1197121 ctttgtccgt gaagcggtgg aaaatacgct cggcatcgga tcgggacacg ggccgacaaa 1197181 ccatttcgct tttaaacgaa acagcttaaa tacaagccga tgagatcacc agctgatggt 1197241 gatctctttt gcgtttgcta cggtatgcgc ttttcatctg gacaaggtta tgatatgata 1197301 ggaattaaga tcaggtacta atactatgtc tttattaaat ataggaggct ttatacatat 1197361 gaatttttca cttgaaggcc gtaacattgt tgtgatgggg gtagccaaca aacgcagcat 1197421 cgcctggggc attgcgcgtt ctttacatga agcgggtgca cgtttgattt tcacatacgc 1197481 tggtgaacgc ctggagaaat ccgttcacga gcttgccgga acattagacc gcaacgattc 1197541 catcatcctc ccttgcgatg ttacaaacga cgcagaaatc gaaacttgct tcgcaagcat 1197601 taaggagcag gtcggtgtaa tccacggtat cgcgcattgt atcgcgtttg ccaacaaaga 1197661 agagcttgtc ggcgagtact taaacacaaa tcgtgacggc ttccttttgg ctcataacat 1197721 cagctcatat tctctgactg ctgttgtcaa agcggcacgt ccgatgatga ctgaaggcgg 1197781 aagcattgtc actttgacgt accttggcgg agagcttgtg atgccaaact acaacgtcat 1197841 gggtgtagca aaagcttctc ttgatgcaag tgtgaaatat ttagctgctg acttaggaaa 1197901 agaaaatatc cgcgtcaaca gcatttctgc cggcccgatc agaacattat ctgctaaagg 1197961 catcagcgat ttcaactcta tcttaaaaga catcgaagag cgtgcaccgc ttcgccgcac 1198021 gacaacacct gaagaagtgg gcgatacagc tgcgttcttg ttcagcgata tgtcccgcgg 1198081 gattacaggt gaaaatcttc acgttgattc tggtttccat atcactgccc gctaagcagg 1198141 atctatatca agcaatcccg aatagggatt gcttttttat ttcttctgat tttcagcttt 1198201 ctgtcatata gatagaatat gacacaatcg gagggatgaa gatgtctaat aagaaaagaa 1198261 acgcggataa aaaaccgctc atgtatattg ttcagccgga ttatgcagaa actacaaggt 1198321 catccatgca ggagattgtc atcaaaagaa aggccgacaa acccgctccg ccaaaagctg 1198381 aggaaaagcc ggcttaccat gagaagcagc aggaggaagc cgtggcacag gatgtcctgc 1198441 aagaagacca aaagcctgca gccgaaccag tgagtcagca aacacaagag gcgagagagc 1198501 cagagaacat aaaaagccaa gaggaacaga aggcagagcc gcaggccgta gaagaaaccg 1198561 ttgaacacga gcccccgaaa gcagaaaaaa aggaagagcc tgcacttgag gcccggaagc 1198621 ctgagaaaga accggaagct gtccatagtg ctgataaagc ggaggaaaaa gcaccgccgg 1198681 cacgaaaagt gaaaaaaccg atgagcaaga tgacgatcca cgaaaaaatt gattttttaa 1198741 caaagctgcc tcataacatg ccgagagcgc tttgtttgat tgaagccaat ggaagaacgt 1198801 acaggggcgt gattgtcgga agaagaaatg attccgtcct gcttcgaaca accggaaacg 1198861 gagccccaac cgaactggca atcgatgata ttacctcttt gcacccgctc ggtttttaac 1198921 gaaaaagaaa aaagctgccc ggctgatgtt gccggacagc tttttttaca tagagaaaag 1198981 cctgcaggcc tgcaagcttt tccagcttat gattaatgat gatgtgtacg attgattaat 1199041 cgaggattta agcagttgat tgcgcagaag cagtctaagt caacttcaat acagtagttc 1199101 gttttttcga gtcggaacac ttcacacacc gtatctttat cggtgaagtc caaaatgtgt 1199161 ttgtgttcgt caaatgcgat taataatgac agtgttgcac agcttccatg cactctttcg 1199221 accctgaaaa atactgtatt aaagcaaggg ccgttatcga gttcgccgac atttccgaag 1199281 gcgactaatg gcgttgattt tgatgtaaat attgcaaaag gcactgtgtc gcctaacgaa 1199341 tggcttacag ataaaagctt agagtggcag ccggtcgggc agtcttcttc aacagcgttt 1199401 tgcagatctt caatattttc tacagcttca cgcacgcagc ttgatgtttt ctggctcata 1199461 ttatccctcc tgccttataa atttgagact ggcgaaatga tggagagtca gctgcctcac 1199521 gctggaagca gctgaatgat ttgcacctgt aatagagttt ggaaggggat tcctctttac 1199581 aagtgtttat ccattgtgat gatgcttttt atctttgtga ggcgatgttc tgtcaactag 1199641 ctctggtgac aggcactgaa tcgcgcagaa gcatccgaga tccacttcaa tgcagaaatc 1199701 tgttttttct agcccgaaga aatccgggtc gcaagggtgg caaacactta aggtatcgcc 1199761 tttgacatcg accgggcgta aaatagacag tgttgcacag caatcgcata atttttcgac 1199821 gcggaagaaa atggattcaa agcattgcat atcatccaca aatcccccta cgtttccgaa 1199881 tgtggagaac aatccgcctt ttttatcaaa aacgagaaac ggaattgtgt cttttccagc 1199941 aatcgtaggg tttaaaaggt tggtatagca gccagtcgga cactgttctt caactgcctc 1200001 ctgctctgct aaaatctttt ccactgcatc gcatacacag ttctcatgcc ggccatgggt 1200061 ttttccgcag ctcattgatt tcagctcctt ctttataggg tatttgactt tagtccttaa 1200121 caacatatgt acccgtgccc cacttggtgt gggtgaacgt ctatatattc atcatatgct 1200181 tggaaaataa gaaaaagcag agcgttttta gctctgcttt taggtcctag aggacaagag 1200241 tgataactag gatggctacg agtgtatttg ttgctgtaga aataagggtt gcgatatcgg 1200301 catctactgt tgtgacgttt acgccgcggg aacattcgat gagaagtttt tggcggttta 1200361 cttgtttgtt agctgtaagc tgtaacaaat cttgtgcgac taattcggca attacgccgt 1200421 ctgcaattga tgtcagagtt gccgttacga cagcggcatt aagtgctgtt acaactgatg 1200481 ttacggcttg aacgtctgta gatgtaacat tgatgtcaca agaatctcta ataataatcg 1200541 tttcatctga aacttgtttg ttgagatttg cttgagctag atcttggtcg atgaaggcgt 1200601 tgtcgttgcc aaaaaaacca ttgccattac agcaaacgtc gcaatgacat tttctttcgt 1200661 gtttttcttt atctttctct ttgtcatcta acggatggtc acagtcagga tcaagtgcaa 1200721 cccaagaata tggtctgctt tccatatcta ttcctccttt tcttttactg ttattaaatg 1200781 agcgagcctc ttattttgac tgagtcatat atcctgatga agaaccctat tttttatgat 1200841 tggctaattg ttatcgtttt tccgtctttg tctgatctgt tcaatgagct gctctctgcg 1200901 gcttaacggt tttgtgttct tttgctcttg tgcggctgct tcttcttttt tcttcttttg 1200961 gttttctatt agcgcttgtg atttagcttg taagtctttt acaagattta agagcatttc 1201021 tttttcttcg tctgatactt ttttcatttt gtcttttgtg accccatgtt tagaaaatat 1201081 attttggacc agcattttcg tcattggatc aacttctgga agctttgcaa gctcttcttt 1201141 gaatttatcg ttatctgaca tttgttttca cctcgtcttt taagtttgtg aaaagaaagg 1201201 gttaaaggac gtcaagttca ctaagaatgc tgtttaacac ctgaagcaag atttgtacaa 1201261 aggttattat ctcgtcggca gacaaagtaa ttttgatgtt gcggctgttg ataattttaa 1201321 tgatggttct ttttttgatt tgggagctat cgagaataag aatttcactt gccactgcgt 1201381 cagccaaatc ctcgtcggcg atgacgagct gagtcgccac gataatcatg gttgtcacaa 1201441 aggcttgtat agaaagggca gctgttatat gtgacgtgtc aattgtgata ttttcgcaat 1201501 caatcacttc gatctgctgt tcgaattcgc ttgataattg ctcaaatatt gcagggtgca 1201561 gggattcgac tttttcttca aatgacataa ccttcactcc tttcttatcc atactctata 1201621 taatgcaaat ggggtgcaga gcggaataat aaaaataacc aattttctgc cggacaagat 1201681 acaattcatg aagaataggg ttttggcata tatgtgaagg gatcatgatt ggcaaaggag 1201741 tgaacgagtg gttataaatg ggctgacaat tgttcttcta tcgcttgcgg tctttcggct 1201801 cgcccgcctg ctggtgtttg acacgattat ggcgccgctt cgcagtctgt ttcatgaaga 1201861 gaaggaagaa aaggatgcgg acgggaacat tgaaacctat atcgtgatta agggaaccgg 1201921 tgtcagggcg tttattggtg aattgctgag ctgctattgg tgcacaggcg tgtggtgtgc 1201981 cggctttttg attttatgcc aggcggtgat cccgcaagcg gcgcagtggc tgattttact 1202041 tttggcgatc gccggccttg ccggcattat agaaacgctc gtatcaaaat ggctgcaaga 1202101 ataaggcgtt accaccagca actttctgtc agaatacgca taaagtagca tatatgacat 1202161 aaggaaagga aggggacaaa aatgaatcag catcataaac cttcccaaaa atctccatat 1202221 acagattcat cgtatcaatc aaaaaagata aaaaagaaag gctgcgggtg cggaaataaa 1202281 aagaaaaagc ctcaatagcc tggcaaagaa accggagaac tccggttttt tgttttttta 1202341 acgaggcggt ctcgctcagc atatatcata agcgggggga taaaagtgaa tgagtttgaa 1202401 aaatggatag aaggaagata tgaaccacat gaacaaaagc aaaaagagca tgaagacacg 1202461 atgggcagta tcagaaaaga cttggatgca tttgataaag ccggtctgga atttgaagat 1202521 gagattgaag agctggctga aaaaacggag gccttactta aaaaacatca agctcaatat 1202581 gatcaatcgt aaatccgcaa acgccctatg cgaatatcca agccgatccc agcagctcac 1202641 atagtgtata gagagtaaag gaggtgctta tctatgggct ttggatacgg attcggcggc 1202701 ggctacggcg gcggctgtta tggcggttat gctggcggtt acggcggcgg ctatggttca 1202761 acatttgttt tgttggtcgt attattcatt ctcctcatca tcgtaggtgc atctttcttt 1202821 taagatgtat tgaggaagta cgggttataa cccgtacttc cttgccttgt gtttattttt 1202881 aaaaatgttg gaaaagcaca ttgtattatg tgcattcata caataccgta ttactccgcc 1202941 aaaaggaggc gcattatgga taatcaattt tttaagaaca tcgaaaagaa aacaggtgtg 1203001 aagatgcagg atgtaatgaa tcttgccgga tcactccaaa acgctaattt taaagatgaa 1203061 aatacagtgc gcagtgtgat taaccgcgta gcgcagatgg caaacagacg cgtgccaaaa 1203121 gaattagaag ataaaattgt ggaatctatt acaagcggaa aagaaaagct tgattttggc 1203181 acgatttcta aaatgatgga taataaataa gtggatggcc tggctgactc actgcagcgg 1203241 gccttttttt acagtaaaaa cccggcagta atctgccggg ctgttaatga tgcaagggct 1203301 gtcttgcttt ctgtagcagg ggatacaaaa atcttgagcg gttggctgtt ttgccgcgcc 1203361 tgttagcagg gcaagacaaa tataaatgct gtttcgcccg ggtcatggct acatataaaa 1203421 ggcgtctttc ctcctcaaga gcggcctcgt ctccttttct tgccgtttct aatgagaaat 1203481 cgtgcggaat cgagccatct acagtgccta acacgtagac tgttttgaat tcaaggcctt 1203541 ttgaccggtg aatggtcatc agctgaacgc catgttcatc cgttctgttt ttctcagcgg 1203601 ccctcatatg gtctacgtgg gcaagaaagt caggaatcgt tttgaacttc ttggcgacaa 1203661 ccttgatgtc gcgcaggtca tcagagcctt tttccagctt gttgccctca ttgccccgct 1203721 tttttaaata ctcggagaag cccatttttc cttctgcaaa ggtgatggct tctacgggtt 1203781 tcattgtgcg gaggcttgca aaaaacggta cgattttctt gattttgtcc agctggaatg 1203841 gcttcagatc aggcaatttg gccagcgctt tgatcatggt acagtcctct gtaatcgaga 1203901 gcgccttcag cgtattcaaa gcggactgtt ttaaaaacaa ggcgggaagc aagtgtttaa 1203961 tcgcctcggt gtcatcctca ttttggctgg cgtacaagta ggcgagaatc tggcggacga 1204021 tccgtctgct gtaaaacgat tggacgccgc ggtcagctgt atacggaatt gacgattgat 1204081 gaagcctttc atatatagca cggcctccgc tgtttgtgcg gtaaagaacc gcaaagtctt 1204141 ctggactggc tccattttga attttttctt tgatatcgga aacgaccatt gtggcttctt 1204201 cctcttcatc ataaggataa aacagcacag ggacctgaat gtcatcgcgg gccgcttcaa 1204261 gcgttttggc atatctgttt ttgttctttt tcacaacgat atcagcacta gagacgatcg 1204321 ggtgcgtaga cctgtagttc gcagttaaat agatcgtctt cgctcccgga taatcctttt 1204381 gaaaatcaag aatgaaagac ggattgcttc cgcgaaacgc gtagatggac tggtcatcgt 1204441 ctccgacaca gcacaggttt tgctccgggc tggcgagcat ttgcatgatt ttgtattgaa 1204501 ccggattaat gtcctgaaac tcatcaatta agatatacgt aaaccgagat tgatattgtt 1204561 ccagaaggtc aggccgctcg ataaacaatt catagcaggc tgaagccatg tcatcaaaat 1204621 caaattggct gtgttctttt ttctggcgtt cataatgttc atataaacga taaacttgtt 1204681 tttcccactc atcttttaga gggatgcgtt catttgggac ataagtgttt ttccaaaaac 1204741 cgatctgctg cagggcttgg tcaactgggg attctttctc atcgatgcct tcttcataga 1204801 gtgctttttt gatatattgt tcccgctgcc actccatttt cagcagatgc tcaccgttcc 1204861 atttagcaga attagagtga tacaagatct tataaaacag actgtggaat gttcctgtca 1204921 caattcttct gacttttgcc ggctgtaatc cgtactggtt cgccatacgc tctttcattt 1204981 cagcgacagc ttttgttgta aaggtgacaa gcagcatatt ttcaggcggt atgcctaagt 1205041 gttcgatcat gtgggcggca cgggctgtca gtacccgtgt ttttccgctc cccgcacctg 1205101 caagcacgag gagcgggccc tctgtttccg tgacagcttt cagctgatcc gtgtttaaac 1205161 cgacagacgg aaaaaggctc gtatcgggtt ctattgtttt tggcacaaat ggtgttcctg 1205221 gtttaatgct tctaggacgg tgccattctg taacagctgg ggacgggtca gcggcgatcg 1205281 cttttccctt gggtaaacga atgacaccag attcctgatc atcttctttt ttcccctctt 1205341 tagagggctt cggttcgcac gcctcctcac atgccggaaa atcgcctggc tggcgatgga 1205401 taaactctgg cggatcggcg atgttaagcc gtaacaaaac gggctttccg caatgagaac 1205461 aaaataaatg tccttttatt ccctcttcaa agaggaattg ataatgttct ctcgaatatg 1205521 tatgtaaatg tatgattcta tcattcagtc gggcgcattt caaaaagggg tcctcccaat 1205581 caaaaggtgt tcattacaga caatgactat catatcaaaa gaaatgtgtt tcaaaaagta 1205641 agtttaaggg aaaagagaca gcagaggggt gggtattgta tgatatatgc aggtcaaatt 1205701 cagaaccagc aatacgctca atatgctaat agaacgattg gacataagca ggattatgcc 1205761 ggaaccgaaa aaatcagcta tgtcccgttt cagcgggtat acaaagaact ggaaaagcag 1205821 caggagaatc aaacggcagc tgaaagaaaa gtaaacgaga tgaaacgtaa gcgctctctt 1205881 tataagagat tgcgagaaaa aggaatgggg acatatatta atcgatatgt ataaaaaacc 1205941 gttcatacca gagaacggtt tttttatatg cagtaaaaat ccggatctca aaagatccgg 1206001 atgcgttcag tccttcatca tttgtaagtg cggaatgccg gcatcgagga attctttttc 1206061 agaaagcacg cgatacccgt gtttcttgta aaacggcaca gcctgtgttt gcgcgtttaa 1206121 aatgaaaccg gaagcgcctc cgtctgccgc ggctttttcg agcgctttca taatgatgcc 1206181 gccgacaccg gctgagcggt ggcttttcag tacgcaaatc cgctctaact tgccgtagcc 1206241 gtccttcatg cgccatcttc cggcaccgac aggcttttca ccgtcataca cgacgatatg 1206301 ctctgactca ttttcaagtt cgtcaatttc ttcttcagca ggcacgtttt gttctttgac 1206361 aaagacttct tctcttacat agaatgcatc tttcagttgt tcttcatttt ttgcgataac 1206421 tgctttcaaa cattattctc ctctgcctag caagaaggtt tcatatactg tccacgatcc 1206481 gttttccaac tggtagagca agtggaaacg gtcaacgatt tcttcatgcg acacttcctg 1206541 catttttaat tgtcccagca catctgaatg ctcatcgtcg gaaagatttt ggccgaccgt 1206601 cacatgcgga acgaaattat attcctgttc tcctgccaac acaccggtgt atagcttttc 1206661 attgagtgtt tttaactctt ccgtcggttc tgctttgatg taaatgacat tattgacagg 1206721 cgcaaatgag ctgtattttg tcattttgag aacgagtggg tgggactctt ttgcgatgtt 1206781 tcttaaatgt gatacgagct gatccgcttt ctcctccgcg cattcaaagg atgctctcag 1206841 cgtcaaatga ggcgggatta gagagtagct tgggtcatag cgctttctgt aagagtttgc 1206901 aaggtcttgg agcttttttg atggaaataa aacgattccg tatttcatat tatgtccctc 1206961 ctggaaataa agtatgatag agtgttaaag catttttttc agcgccgggg tgatgagcgg 1207021 ctgccagtat gtccatttgt ggtctccgtc aaatggctcg aaatcataat cggaaagctt 1207081 tttctccagc agctgtttca gctcccggtt cggttctgta aagtccagaa tgttcccgtc 1207141 tgtcgtgtgg acgtcagttt cttttgttcc gatttggtga taaatagaga ggtgtttgat 1207201 atcgtctgac tgttttacgg cttctagtac gtgtttgtca acatagggag actgcatgat 1207261 gatgttgcca aacatattcg gataatcaag cgctgtcata agtgacacgg ttgctccgag 1207321 cgaatcaccg atcagcgttc ggccgtaacc gatctgatag gttggatact catcatctgc 1207381 aaaaggaacg agctcatggg cgatgaaccg tttataagcc gaaaattttg aaccctccgg 1207441 atgataagtg tttctgcgct cttttacatc cttataggga acaccgataa taatgctccg 1207501 gtctatttcg cgtttcgaca gcaattcctc aacctgtctg ccgattctcc ccagcctgaa 1207561 ataatcgtgg ccgtcctgcg cgataatgac atggtattta taaagcgggg agtagttgga 1207621 cggcagataa acaagcaagg tcatttcctc gttaagctct tttgaaaaga atttcttttc 1207681 ttgcactgtg ccgtttttcg gtgccataaa aacattcctc caggacatca ctatactttc 1207741 ttgcattttc aattattgta ccatgaatta ttagaaattt ctctctttaa acggttcggc 1207801 acacgaagaa aaaagtgttg aaataaactg tgaattgcgc taatataaaa caatcagaaa 1207861 attgaaatcg atatttctta tcgtgagagg tggagggact ggcccttaga aacctcagca 1207921 accggcttgt tttgcatttg caaagcgcca aggtgctaaa tccagcaagc gttttttatg 1207981 cttggaagat aagaagaagc gttaaacccc ttcttcttat gaagaagggg tttttatttt 1208041 gaaaagggaa ggtgtcagct atatgtcaca gcacgttgaa acgaaattag ctcaaattgg 1208101 gaaccgtagc gatgaagtca cgggaacagt gagtgctcct atctatttat caacagcata 1208161 ccgccacaga gggatcggag aatctaccgg atttgattat gtccgcacaa aaaatccgac 1208221 acgccagctt gttgaggacg cgatcgctaa cttagaaaac ggcgcgagag ggcttgcctt 1208281 tagttcggga atggctgcta tccaaacgat tatggcgctg tttaaaagcg gagatgaact 1208341 gatcgtttca tcggacctat atggcggcac gtaccgttta tttgaaaatg aatggaaaaa 1208401 atacggattg acttttcatt atgatgattt cagcgatgag gactgtttac gctctaagat 1208461 tacgccgaat acaaaagcgg tgtttgtgga aacgccgaca aaccccctca tgcaggaggc 1208521 ggacattgaa catattgccc ggattacaaa ggagcacggt cttctgctga tcgtagataa 1208581 tacattttat acaccggtct tgcagcggcc gcttgagctg ggagctgaca ttgtcattca 1208641 cagcgcaacc aagtatttag gcgggcataa cgatctgctt gctggacttg tcgtggtgaa 1208701 ggatgagcgg ctcggagagg aaatgtttca gcatcaaaat gcaatcggcg ccgtcctgcc 1208761 gccatttgat tcgtggcttc tgatgagagg aatgaagacg ctgagcctca gaatgcgcca 1208821 gcatcaggca aacgcgcagg agcttgcggc gtttttagaa gagcaggaag aaatttcgga 1208881 tgtgctgtat cccggaaaag gcggcatgct gtccttccgt ctgcaaaaag aagaatgggt 1208941 caatccgttt ttaaaagcac tgaagaccat ttgttttgca gaaagcctcg gcggggtgga 1209001 aagctttatt acataccctg cgacccagac gcacatggat attcctgaag agatccgcat 1209061 cgcaaacggg gtgtgcaatc ggttgctgcg cttttctgtc ggtattgaac atgcggaaga 1209121 tttaaaagag gatctaaaac aggcattatg tcaggtcaaa gagggagctg tttcatttga 1209181 gtaaacacaa ttggacgctg gaaacccagc tcgtgcacaa tccatttaaa acagacggcg 1209241 gaaccggggc agtcagtgta ccgattcagc acgcctcgac ttttcaccaa tcttcatttg 1209301 aagagttcgg ggcatatgat tacagccgct ctggcacgcc gacaagaaca gctctcgaag 1209361 aaacaattgc cgcactggaa ggcggaacaa gaggatttgc tttcagttca ggcatggctg 1209421 ccatctcaac agcattttta ctgctgtcac agggtgatca cgttcttgtg acagaagatg 1209481 tatacggcgg aaccttccgt atggtgacag aggtgctgac ccggtttggc attgagcata 1209541 cgtttgtcga catgacggat cgtaatgaag tggcgcggag catcaagccg aacacaaagg 1209601 tcatttatat ggagacgcca tcaaatccga cacttgggat tacggatatt aaagcagttg 1209661 ttcagcttgc aaaagaaaac ggctgcctga cctttctgga caatacattc atgacgccgg 1209721 cactgcagcg tccgcttgat ctcggcgtgg atattgtact tcacagcgcg acaaaattct 1209781 taagcggaca cagcgatgtg ctctcaggtt tggctgctgt caaagatgaa gagcttggga 1209841 agcagctgta taagctacaa aacgcgttcg gcgccgtcct tggcgtgcaa gattgctggc 1209901 ttgtcctgcg cggattaaaa acattgcagg tccgtttaga gaaagcgagt caaacagctc 1209961 agcggcttgc ggaatttttc cagaagcacc cggcggtcaa gcgcgtgtat tatccgggac 1210021 tggctgatca tcccggcgct gaaacccata aaagccagtc aacgggagcg ggcgccgtgc 1210081 tatcttttga gcttgaaagc aaagaggccg ttaagaagtt agtcgagaat gtgtcactcc 1210141 cagtcttcgc tgtcagcctt ggcgccgtgg aatcgatttt gtcctatccg gcaacgatgt 1210201 ctcatgcggc aatgcctaag gaagagcgtg aaaaacgcgg tatcactgat ggcctgctcc 1210261 gtctgagtgt cggcgtcgaa catgcagacg atttagaaca cgatttcgaa caagcgctga 1210321 aagaaattgc tccagtttcg gttcgttaaa aaagaagccg gggatagtcc ggcttctttt 1210381 attattgttc gtcatcagga ttcagaatcg cgaggacttg atgatcctcc caaacgccat 1210441 taatttttac attttttcgg gcgatgcctt ctttatgaaa tcccgctttt tctaaaacac 1210501 gcatggaccc gagattacgg ggcatcacac cggcttcaat ccgatgcagt ttcaattcgt 1210561 ggaacgcata atcaacaacc aatctgactg cctctgtcat aatgcccttt ccattatggg 1210621 ctttgtctaa aaaatacccg atgaacgcag tttgcagcgc gccacggatg atttgaaaga 1210681 gcgaaaccgt cccgattaat ctatcgtctg acgctgtaaa gatgccaaaa tgatattctt 1210741 catctttctc aagtctttcc tgatactcgg ttattcgttt tctttgcccc tcaaccgtat 1210801 agtaatcgtc tgcgcgtatc atagaaaact gttcgaaaaa atctcgattt tcgctttgca 1210861 gccccagatt ttcttcggca tccgttactt ctaaaggtct aacataaatg gtttttcctt 1210921 ttaacatata gtgatctctc cgttctcatg tcagcattcc tcttacatta ttctcaggga 1210981 aatgcaaata tcctttttat aagaaggaag aaaaccaatt tcccataaaa gtgccaacat 1211041 agttgccgat taagtagccg agcgtaccga caagcatgat cggggcgaca agctcccgcc 1211101 atcccttggc aattgccatc gcagccgcag tcgtcggtcc cccgacagta gcgttgacgg 1211161 cgagcagaat ttcttcaagc cgcacacgga acaattttcc ggcagctaag gaaaccgcta 1211221 aattgctaat cgcaatgata aacacgaata atagaataag aggcgcattc gtgacgatta 1211281 agcggagatc tgcaggaatg ccgatcacca caaaaaacaa ataaatcaaa aaggttccaa 1211341 gctcctgaga tccattgagc ctttcaaaaa aacgcgggaa aagaaaaatg ataagaacag 1211401 ttaaagacgt aagaaccagg tactgatcgc caagcgtacc ggtcagcagg ggatgagaaa 1211461 aaatgctttt aaaataaccg gaaaccttca tactaaccgc aacaagcgcg aaagcggcac 1211521 cggcattaaa agcgatatcc tttaaggaaa tatccttccg tttccaatag ctttcagcac 1211581 tgtttccgct gtttccatcg gcttttacct tctcttcaaa cggcatggca taatgccgct 1211641 gaaaccattt gagtgcagga atgctgatta aaataaaaaa caaaagcgcc atcataaaat 1211701 tatcagccac aacggtagcc gacacatatt caccaggcgt ctcaaatttt gccgccatcg 1211761 ccgcaaagtt gaccccgccg ccgatataag aggcgctgat catcccaccg attttatcta 1211821 agtaaggaat atgctgtttg agtagaaaaa aagccaggat actgccaagc actgttccaa 1211881 cggagctaat cagaaaaata aacagcaaac gcctgctttc cttaaaaatt tgcctaacat 1211941 tgatctgaaa caataaaagt ggtatcgcca gcggtaccac ataagaccac acagtgtcat 1212001 acacgggcga ctcaacagga agcactccta catttgtaaa caccatagca cctgcaaggg 1212061 cgataatagc gcccgacaca gcagacgccc acttaaagcg ctgctccagc ccgatgctca 1212121 ctgccgccca caccgcaata aacccccata atacccatac atcatcagaa gaaatcaaag 1212181 aatgcaaaac cccatcacct ctattgttag aaaattaaga catattataa tagccgggga 1212241 acggaacagc aagtccaaaa aaagtttttc taaaaaagca gttgacgaat agaaggtaag 1212301 gttatataat agaacttgtc agaaagataa caacataccc agcaacacat acatatcatg 1212361 attccgtagc tcagctggga gagcgctacc ttgacagggt agaggtcgct ggttcgagcc 1212421 cagtcggaat catagcttaa acccttgcgc agcaagggtt ttttactttg cgttaataaa 1212481 gccggttcgt caaattcgtg agttgttggc gaactgttgg cgaaattcat tgaccgcagt 1212541 ccaaaaacta cctccaaact tacttgatta gttcaatagt aacaaacgga agatcggatt 1212601 tctgttaaat cttcattgag aatagccagt ccaagaccgt cacttcagcc atgcatcttt 1212661 taaatgaaat tttgtactga aaacatcaat tgtattttta aattctgctc tagaatcagc 1212721 ccctttataa taatcttgat aaattgcttg gggtgatact gattcgtgat ttgtgctatg 1212781 gtttgcaagg cttgtagcaa aagcaggagc aacagtaacg agtaaagcaa gggataatgc 1212841 aaaaccagtt aaagcttttt caatttcatt ttaagcactt ctttttttaa aatacaactt 1212901 tattattaaa tggaatacaa aaacatccaa ggtgtttttt tgttagtaag ttgagttagg 1212961 gggattggat ggcacttaga atattgtttc tgctgatggg atgttgattc tggatatatt 1213021 tccaacacga ttacaggccg gacatgaaag cgaaccttgc tttgatcggg gcaatcattt 1213081 catttacggc tgcggtttac tttaaagata ttgatgtatt gagagaagag ggaaaacaaa 1213141 tgaacggaat ttctgagcgt tggaacacgt ttaaattaca aaaatcccct gaaccactct 1213201 agatcagggg attgctttcc caacagctta ttaagtagcg gaaggcatga tcaacgattt 1213261 agtatcaatt tattaattgc gaatactaga aacataccgt tttccgcctt ccttagaagt 1213321 aacatattct cgaggaacat taagtctatt ggtagaatga taacttacat aaagtttcat 1213381 atttgctcgg ctcgttacga tagccgtatg atccatccaa ccatcagcat agcgaagacc 1213441 tattttatta tggtaatcat agtgatatac atctccaagc tttacatttg aatatgtatc 1213501 agaaacagtc ttcattttta ttccgccagc ttttaaaatg tatgatctaa aggctcctgc 1213561 attaacccaa gcatctgtat agggtttcca ttctttaaag tacggcattc ttccagctct 1213621 taatgcttgg gaaacaaagt tagtacaatc tttgtcttta taatatttat agtttttatt 1213681 tggttttaag gcatattttt ctgcatattt cattgcagcg taaccactat atcctttaac 1213741 agatgttgca gtcacagtta gttgattaga gttagcagca ttgaagttca tacttactgg 1213801 tttatcttca cttttcactt cttctttatc atcatttttc acttcttgct tatatttttt 1213861 taaaaattca tctaatttaa catccgaaga atattcttca tcattttcat attgtagagt 1213921 tgaagaagaa ttatttaatt gtgttacatt tagttgctta gaagaattac tcaatggtat 1213981 tacatttagt tgattagaag aatttttaac ttgagagaaa cttagattag aagtatttgt 1214041 tgattgagaa ctttgtttat tagaagttgt tttgggaatt tcaagtttaa tattatcgcc 1214101 cagagatgtt gttacttttt caacaccaaa aacaaagttt cgagtaatat aagcttcaac 1214161 aattagctta ttgttttttt cagaagtctt aacatcgtct atatcgtatg taaactcgtg 1214221 gaatttttgt ttgtccactt tacttaacgc agaatacagt aagactcctt cgtcggaatc 1214281 agtcaattta gactctttag gatgcgctaa aggagtgttg tgttcaaaat catatttttg 1214341 ttgttctaac atatccttaa ctttttcgta accaatctcg ttggtaattg aaacattttc 1214401 tttagtctct ttattagtag tggctgcaaa aacttcattt gttgacacta atggtgacaa 1214461 tgatagacat aaaactagtg aagcaagtaa ttcttttttc atacgaaacc tccaataaaa 1214521 tctaaatata agtaatattt atcatttaca ccaattgaaa tatggcataa aatacatgta 1214581 ataatataac ataaaaataa atacataaaa aggtatcgga ggaaaaaatg aaaaagaaaa 1214641 ctaaaattat actttctctc ttggcagcac ttattgttat attgatagta cttccagttc 1214701 tatctcctgt tgtctttaca gcttcttcgg aaaaaggagc aatcagacac gaaatttata 1214761 aaagaggata tccctaccaa agctactttg cagttctcca gaaaagagaa ggagacaatg 1214821 aatctgggaa tctttattat gtaaattggc tagattggaa agatgaaaca gggcaaactc 1214881 ctcacttatg ctattcgaaa aaatcatcag atggtgaata cgaagtaagt tgtggcacag 1214941 ggccgtaaaa ataaatttta aaattgaata agtccaagac ggaaagcctg cggacactga 1215001 tcgttttaca gagaaatttg tgcttcgatc ggtgtccgtt ttttttcgca actaaccaga 1215061 tgtctatcgc gattactagc tatgaaagga gtaattagac atgaaacagt ccaaaaagaa 1215121 accatcacag aagcaacatg agcgcttaga tcgtttctgg caacaaatga tgaacactaa 1215181 catgcaaaca ctcagacgtg gcaaaggcgg cgcttataaa cgcagaaagt aaaaagggag 1215241 tttgaggatg atgaaaaacg gattcgctta taaaaacgga aagcttgtga atatcttttg 1215301 cggcaaagaa gagctctata acgagttgaa agccttcttg gtcaaaacct tcagtatcaa 1215361 cgtgaaagag gtatcgaggc cctcaatata tcgcagaaca aaaagcaaac aactggaatg 1215421 acacttactc tatttaacta tcaggaggga aagcactatg acagatcaaa tgattgcatg 1215481 ggagattgag gaatggattc gtgattataa attcatgctg cgggagatca aaaggctcaa 1215541 ccgtgtatta aacaaagtgg attttattag cacaaagctc actgcaacat acggggagga 1215601 agcgggcatg ccaaggggat cagcaggcgt cagtcaggca gaattgcggc agatggaccg 1215661 aagagaaagg cggcttcaca aatatgaatc tattgtgcat tacctggaca atgcaatgga 1215721 acacattgaa gaagaaaagc accgaatcgt ttacgattgc atgatggaag gcatgagcta 1215781 cactgctatt gcaaaccacc ttgattgctc ccgggatacc atcagaaaga tcaaaacagc 1215841 cataatcggc aacatcgtca ataaagtcaa agaagccaac tttctgcaat atttgaattc 1215901 gtttaaatcg gcggtgtaaa atggggggca ggatcggcgc ggcggattat tcctgcgtca 1215961 ccaccaattt catacaatga gtaaaacctc ccagtggtaa gcgaggatca actcaactgg 1216021 gaggtcttac atagtgaatc ggtgataaaa cagcagcagt attgcgtaca tgttaatatc 1216081 cccgacaaaa tatgtttttt tcaacagatt cgttcgacaa attttgcaaa ttgttaatcg 1216141 ataacttttc attcccgata ttaaaaatgg gagtgaattg taaaatgaaa aaacagaaaa 1216201 ataataaaaa gaagaatatt gaaaagcgaa atattgaaaa gcgaaatatt gaagagaaga 1216261 ataatgagga cttagaagaa ctggaaaatg cgatttatac ttatcacaaa aaggagctac 1216321 ttgctttctt tcttgaaaaa actcgaattg gtcatgataa ggaagaatac aaaaggttcc 1216381 aatctcttct ttataagttg gatattgaat gtttagaatt tgctatatcg agattttctc 1216441 atatagatat tatccatgat cattcaaaat atgttccagc ctttatccct ttatttgcag 1216501 catatctcac catgttcttt aatttttatg aaaaacattg gggagcttta tcttttgctg 1216561 ctggtacaat tgctgctatt gtttggataa ttgcagtaga aagaaaacat agaaatcaag 1216621 caatttctat tatgaaaata tttgaacaag tcaaagagag aaaagtgaaa gacagatcta 1216681 aagactgaaa ggagaaaata tgaataagga taaattaagg tatgcaatct taaaagaaat 1216741 ttttgaaggt aatacccctt tgtcagaaaa cgatattgga gttactgaag atcaatttga 1216801 tgatgctgtg aactttttaa aacgcgaagg gtatatcatt ggggtccatt attcagatga 1216861 tagacctcat ttatacaaat taggacctga actgacagag aaaggtgaaa actacttgaa 1216921 agagaatgga acatggtcta aggcctataa gaccattaaa gagattaaag attggattaa 1216981 ataataagag catcctgcgg ggtgcttttt ttgttccctg taaactgctt ccggtaagtc 1217041 tcaggataga caattggcgg ttaacggctt gagcacggtg gtggtttaga gggaatatct 1217101 tttccaaaac aacacgaatc agaagggggc ggcggtgaat gtagatggcc gaaaagcaca 1217161 ttcaggcgta taaggattac gtcaaaggca tgaaatacaa ggaccttgcc gagaaatacg 1217221 gggtgtcagt gaacaccatt aaatcgtgga agcagcggca tggttgggaa aggaaaaagg 1217281 gtgcacccat tgaaaaaagt gtgcacacaa aaaaaggcgg gcaaccgggc aacaaaaatg 1217341 cattagggaa caatggcggc gcaccacaga agaatcaaaa tgctgtgact cacggctttt 1217401 tctctaaatt cttgccagaa gagacgcttg aaatcatgga agagattcag gagcgttcgc 1217461 cagctgatat gatatgggat cagatacaga ttcaatatgc ggccattctt cgggcgcaaa 1217521 agatcatgtt cgtttctgat aaggaagaaa tgatcaaaga gctgaaaaag aaaaggtccc 1217581 tcatatctga ggtcagcgaa attgaagatg ggcttgtcat tagttttagt acgtggtttc 1217641 gctacagact ttacagtgaa acaaacacct aacacatttc acattgcttc agattgcctt 1217701 caaacttgat aatataactt ctaaaccttc ctataaaatg aaggtttttt atttgatttc 1217761 aatttttaaa tcctttacat acagcgattg attaactcga gcaatcaatg tcgcagttat 1217821 atttattttt caagaaaatg ttataatgaa aagccataaa atgatgggag ggggaatttc 1217881 gatgcattac ataacggcat gtttaaaaat catcagtgat aaagacctta atgagataat 1217941 gaaggaattc aaaaaacttg aggaagaaac gaacaaagaa gagggttgta ttacattcca 1218001 tgcttatccg cttgagccat cagaacgtaa aataatgctt tgggagattt gggaaaacga 1218061 agaagctgtg aaaatccatt tcacaaaaaa acacacaata gacgttcaaa aacaagaatt 1218121 aacggaagta gaatggttaa tgaaaagcaa tgtgaatgat tgaaaggctc tttaaaaaga 1218181 gacattcaat gacttagtat cagccacttg tgactaagta gtaaattgtt gtccaactct 1218241 tattttttct atttaatatt ttttgagacg aaaatgtttt tttaagctga ttttaaaatg 1218301 tattcaaagt cagctctgtt tgatttaatg gattatatta tttggatagc ttgttaccat 1218361 cataatggag atactcctta taaattggag gttaaaataa tgagtcattc tcaagaaaaa 1218421 attgcactaa ttacaggagc aagcagtcaa ggggatattg gtacggctat ttgtcgtaag 1218481 ttagcctcac agggtataca tatcttcttt actcactgga attctgatac ggcctggata 1218541 gaagaatttc aacaagaaat tttacgtatg ggtgtccgct gtgaggcaat gaaaattgat 1218601 ttatcagatg cacatgctgc attcacaata catgaaaaaa tttcagataa attaggatat 1218661 ccttccatcc ttattaataa tgcagctcat tccgcaagtg ataattatgt atcgttagat 1218721 gctaaatcac ttgatgagca ttatgcggtt aatatgagat cgaattttct tctttgtgtt 1218781 gaattcgccc gtcggtttaa aaaatctaat ttaatatcag gaagaatcat caatatgaca 1218841 tcagggcagg atttaggtcc tttgcctggg gagttagcgt atgcagcaac taaaggagct 1218901 atttctgcat ttactaggtc gttatcacaa gaacttgcac cattgggcat cactgttaac 1218961 gccgtaaacc caggtccaac agattctaca tggatgacag atgaaataag aaattttctt 1219021 tcacctaaat ttccaatggg gcgtattggc acaccagatg atgcagcacg aatgattgcc 1219081 tttcttgcaa gtgatgaggc tgaatggata actggacaaa ttattcattc agaaggtgga 1219141 tttattcggg gctaagctaa tgaaacacgg tatacaccaa tgtatgatgt attcccaaaa 1219201 ctaaatctaa acttgaagcg aaaataaggt cccttctctt tttagagggg gaccttattt 1219261 tattcatgca tgttttgcat ccagaaaatc tggcggataa agattaataa accgttacat 1219321 atacttttcc gaatactgca gtacctttaa acaaagtaat cgtggctttc ccttttgatt 1219381 tagccgtcac taaaccattt tgatcgactt cagcaacttt ttggttatca gtccaataac 1219441 gagtagctga attattttta acagaatagg tttctccaac ttttagaggt aaattatagt 1219501 cttgaatctt gataacatgt gtaggtgaaa tagaaatgtt ctttacttca gtaggtgtgg 1219561 agtttatttc atgagctgaa gctaccccgc tgaccgacag agctaacgca gaaatcgata 1219621 aagcagaaac aaccgttttt ttgaaattca ttttgaaaca ctcctttaaa gttttttgtc 1219681 ttgcactata acaattcaat aaaagtaatt attttccttg taaataaatg ttaataatat 1219741 gtgaacgatc aattgatttg agctaagaat attgtgtgcc ctgcacagag tttgtattta 1219801 tgatggaaaa ttgctgagag agaatggcca tccttaaaat gttaatagca cacatttgat 1219861 gggtattagt ttgttgagcg tgtggaaatt ttgttacctg cactttatcc ccgaagatac 1219921 caaatcactt ttcttcatca tgttcttact ttcgtactca tacattagaa aatcttcgtt 1219981 ctaaataggt gaagaattgg agtattttta tgaatttctg ctgaatatac attacatagc 1220041 aaactcaaag agtataaaaa tcgctttttt ccggaagctt cggtaaaaaa cgaaactttt 1220101 gtctctatga ttttgtttta taatgtaaac ggtttcttat atagtatact tatactatca 1220161 atttgctcaa gtagatactg acaggaagga tagaaaaaca gatggaatac ataaatacaa 1220221 gacaaaaaga gattttgtat ctgttgttat ctgaacctga tgactattta gttgtgcaag 1220281 atttcgcaga tagggtacag tgttctgaaa aaacaatccg gaatgatttg aaagtgatcg 1220341 aggattatct caatgagcat tctcatgcac agcttattcg aaaaccaggg ttgggcgttt 1220401 atttacatat agaagaacag gaaaggacct ggctaagcca acaattacat actgaacatt 1220461 tttcttctag gcagcggagc gataaggaaa gaatgctgca cattgcttat gacttattaa 1220521 tgaatccgaa gcctgtttcc gcaaaagaca ttgccgctcg gcattttgtc aatcgatctt 1220581 ccattaaaaa ggatttatac gcagtagaag agtggctgaa gcgttttgat ctcacactgg 1220641 tttctaggca gcggcttgga ttaaaggttg aagggaacga aagaaataaa agaaaggcat 1220701 tggcaagaat atctgatttg attcacaata cagcgtttac cagccaattt attaaaagta 1220761 agtttttaca ttatgaagta gactttgtga cgaaagaaat caaatcacta caaaaaaagc 1220821 attccctcta tttcacagac gaaacgtttg aaagtttgtt gctgcataca ttgttaatgg 1220881 tccgccgcat caaaatgaag cagccgattt cattgtcccc aaaagaaatg gcggcagtaa 1220941 aaaagaagaa agaatatcaa tggacatttg cttgtttaca gcggcttgaa ccggtttttg 1221001 caattcgctt ccctgaagaa gaagccgtgt acttaacatt acatatattg ggcggtaagg 1221061 ttcgttatcc attgcagaca gaagagaacc ttgaaaatgc tgtgcttcct aaggttgtag 1221121 ggcatttaat caatcgtgtt tcagagctga aaatgatgga ttttcacaag gatcaggatt 1221181 tgatcaatgg tttgaacatt catctcaata ctgtgctaca acggctgagc tacgatcttt 1221241 ctgtagcaaa tcctatgctc aatgacatca aaaagatgta cccttatttg ttccacctca 1221301 tcattgatgt tttggaagac atcaatcaaa cttttgatct tcatattcct gaggaagagg 1221361 cagcatattt gacattgcat tttcaggcag cgatcgaacg gatgcagggc agcagcgaga 1221421 cacataaaaa ggcggttatc gtctgccaca tggggattgg gatgtcacaa ttgctgcgga 1221481 caaaaattga acggaaatat caccaaatcg ctgtaatggc ttgtattgca aaggccgatt 1221541 taaaggatta tatcaaaaag catgaggata ttgatcttgt catatccacc attgcgctgg 1221601 agaatataac ggttccccat attgttgtgt ctccgctttt agagcctggc gaagagaaga 1221661 aattaagtgc gtttatacgt cagctgggcg aatcacaccg ccaaaaacaa aaaacgtttc 1221721 agatgctgaa caatacgact ccttttttgg tttttttgca gcaggaggcg gagcatcgct 1221781 acaagttaat cgaacagctg gcgacagctt tgtttgagaa aggctatgtt gataaggact 1221841 atgcggttca tgcggtgatg agggaaaaaa tgtcggctac aaatattggg tcaggcattg 1221901 ccattcctca tgcaaacgct aaatttatta aacaatcagc aatcgcgatt gccacattaa 1221961 aggagccgct tgaatgggga aatgaaaaag tttcgctcgt ttttatgctg gctgtcaaac 1222021 acgaggatca aactatgaca aagcagctgt ttagcgagct ttcatatctt agcgagcagc 1222081 cggccttcgt ccagaagctg acgaaagaaa ccaatgtcat gacattttta tctcatttgg 1222141 attattaaaa gcagggatta ttccttgctt tttttgttca tggcagggct tgagaaataa 1222201 atttgcgagt gaagacgcct attctccagc aatgatctaa ataaaataag agtttaatag 1222261 ttggagaaga aatgttacac tcttttctgt atatggtaaa gaatgaaaaa acacgattcg 1222321 gttggtagtc cggatgcatg attgagaatg tcagtaacct tcccctcctc gggatgtcca 1222381 tcattcttta atatctttta tgaggaggga atcgttatga aattaacgat ttactacgat 1222441 ggtcagtttt gggtaggcgt tgttgaagtt gtggacaatg gaaagctaag agcctttcgt 1222501 catctttttg gcaaagagcc gagggattct gaagtattag agtttgttca taaccaactt 1222561 ttgaatatga tggcccaagc tgagcaggaa ggagtgcgtt tacaaggcag gcgtcaaaaa 1222621 aagatcaatc caaaaagatt gcagcgccag gtttcaaaag agttgaaaaa cgccggagta 1222681 acttctaaag ctcaagaggc gataaagcta gagcttgaag caagaaagca aaagaaaaaa 1222741 caaataatga aagaacaacg agaacatgta aaagagcaaa ggtatatgct caaaaagcaa 1222801 aaagcgaaaa agaagcacag aggtaaataa tccaaacaaa agcaggcgca gtgcctgctt 1222861 ttgtaattaa ggactctact ttgtaacata tatccaatgt ttatactccg ctgatttatg 1222921 attcaatata aaccctaact tctccaaggt tttttgtgag cctagattat catgttcgca 1222981 tcttgcggtg atccgggata ctgtttctcg gcttaatgcc cagtttatta gtttttgggc 1223041 ggcttccaca caataacctt tgcggcgatg acttttattt gttgcaaaac cgatttcaat 1223101 catgccattt tcgtctgggt cacctaaaaa tccagttccc ccaacaattt cataattgtc 1223161 cttctttaca ataatccatg aatcaaatcc ttttgttcca ttgtttttga ctaaaatctc 1223221 gcggaaataa ggtatcgctt caaaaaaatc agaatttggc cattcaccat ttgtttcata 1223281 gcctaattct ttgatagcct gatgatcttg tttagacgcg gcgtcaagaa ggggaatatc 1223341 aatcgtttgt aatcgtaatc gattcgtttc aaggagaacc atatatttaa tcctcttttc 1223401 tttttactgg gaataatgat aacatataac aattttctct ggtaccttgg cagtagagaa 1223461 agatgaaaaa attgaggggg attgaaagag tgacaggtga gagtttgccc agaccaaaaa 1223521 cgggtaggaa aatgctgatg ttaatgtgtc cctacccgtt tttctgttcc tgaatgcagg 1223581 gtttctgata acatgttgtg ctaccttttc gcaatcaaat aaagcgatat ggctctttgg 1223641 gtttgcacag gattatgaat gataatgacc cattggtttc ttcgtcttgg aaagcttgct 1223701 accgcataca atggagcagt atcgcgcgga gtgaacccac catttatcac gttgatatct 1223761 cttccttcaa gatgacaaac taagtattca cctggattga tgacctgttg gttcgtccat 1223821 gcgtaagaat aaaagccgtc tccaagatct tcggtggaag atggggggac aaagccatct 1223881 acagtcaatg tgatttctct tcttcgctgt ctttctgaaa agtctggact tctttgaggg 1223941 ttatgagtat gtgaaaagta aggaattaac gcagggccat aaaagtaatg atacaaagca 1224001 accactcctt tattttccat tcatacaaat tgtatgtggg agttatttgt tcattcctgt 1224061 tttgttccat gtagactaat aatgggctat aggcgtccaa ggaaatcaat ttgtccttcc 1224121 gttgattcaa tgctagtaac cttgaaaatg caggttagga tgatagaatt tacatattac 1224181 tgcaagaagt tagacataca tcattttgat agtgggtgaa aacaatggcg aaaaaaatgg 1224241 caaaaacaaa tgcggttcgt ctgatagaac agcagaacat ctcttatgag gtattagggt 1224301 ataaaacaga cggccagccg gtagatggca tctctgttgc ggaaaaaatc ggttattctt 1224361 tgaaatatgt atataaaacg ttggttgcag cagcaggaac aaatcattat tatgtctttg 1224421 ttgtacccgt tgcagaagag ttagatgtaa aaaaggcagc aaaggtgaca ggggaaaaga 1224481 aaatagaaat gattgcaatg aaggagctgt tagcggtaac tggctatctt cgcggcggct 1224541 gctcgccaat tggcatgaaa aaattgttcc cgacctatat tgatgcatct gcagaaacgc 1224601 ttgattttat tattgtcagt gcagggaaaa tcggtatgca gctaaagttg gcgccacaag 1224661 atttagccag atcatgtgat gccgcatttg cagaaattgt atagatgcag atatagggga 1224721 acgaaaaagc ttagtcatat cgattaagct ttttccgcat ccctttcaaa tatgatttca 1224781 aaataagcag ctgccccata cccatctata ctgggagcga aaatctgaac gaatctccag 1224841 cctcttttcg cataatcatg gatgatttgc tggtagtctt ctttaggcct tcttctcatc 1224901 gtactcagct caactcttac gaattcatat tctttcatcg tttgatccct cctattaagg 1224961 tatacgtaaa atggagcgag aagttccgaa aacctaggtt aaggtcggaa agtatatttc 1225021 actcactaaa caaatccatt tatgcctgat gcctgcatgc atctgggaag agttaagggg 1225081 ctataaaaac gaattttacc gggtcagcag tccaaatgaa tctcttgctt attgcatttg 1225141 actgagtata taagtaaaaa aagagcggcc agaacatata agaaggagat gatcattaac 1225201 gcactcataa cagggtagtg tttagcggag tagatgaaaa aatcaagctg tgaaatttgt 1225261 ttggggctgc tgacggcatc aattccatta agcagttttg agagtttagc agtatagttc 1225321 caatcaaatc gatctgaaac aagctcgctt ccttgatacc aattaacagc agctaaaaac 1225381 agaaatacca taatagaaaa tccaagctga acaactaaaa atattccctt cacttttgta 1225441 tgacctccaa atctatgaat atgggaaaat caaacaatat attaccaccg tatgggttat 1225501 tcttgcaatt tcacttccat acaactcaaa cgcaagtcta tttttttgtt tgtttttggc 1225561 ttataatacc tgatgatgga aaaagagtgc gggtttatag attagagaaa caaatgtatt 1225621 tcttagcatt ttttatttgt ggagagagta tagaagcatt cgattagatc tgctttttca 1225681 cagaaacggt tttcatctgt ttgcctgagc tttacaattg gctggcaaaa aaacaatgat 1225741 ttctttcaat caaaacatgc aacgatgcga cacattttat atcttgatga cttatttcat 1225801 tgcctttaag tcatcctatc gagaaagcga tggtatttta tgaacaaaga aaccctaaaa 1225861 aacatactca tgattttttc aatatgcgca acactccgag aaaccgatgg tatgcgcata 1225921 gctgatagct ggattttgag tgagattata cgatttttga tttgcatggt tgtgtttttt 1225981 gccatgacat ttctattaga tgctgttttt ccaaacaaaa aagagtcaca ttaatgtgtg 1226041 gctctttttg catcatctga tcagaaacat cataaatgaa tcgatcatca tgatgaagaa 1226101 cagcaagcaa aaataaataa gcgagtagac aaacatatcc tttgcccact tcacgtcatc 1226161 gtctgttttg aatcctttga tgcttttttt gatccatatg cctccgagaa ccaaggcggc 1226221 taagaaataa aatgggctta tatggccggt gccgagagag aaaggaaata atagcgtgac 1226281 cggcaccagg acggcaatat attgcatcat ttttattttt gttacatgat tgcctttgac 1226341 tactggcaag agcggaacgc cagcagcgcg atattcctct ttgcgtctta tcccaatcgc 1226401 ccaaaaatgc ggcggctgcc acagaaacat aatcgtgtac aacagcactg ctgtcatact 1226461 gaagtcaccg gttacggcac aataccccat caatggcggc gcagctcctg ggaagctccc 1226521 gacaaatgtg ctccacacag acgttcgttt cacccatacc gtatagatga tcgcataaaa 1226581 aataaaggcg gccagtccga gaaaggccgt taatggattg agggaataaa gcatggcaag 1226641 acctgcgatt cctaaaacag agccatatgt taagatcatg gctggcggca ttttccctgt 1226701 gaccgaggcc ctgctgcgag ttcgtgccat ttttgcgtcc atatgccgat caaaatagtt 1226761 gttatagaca gtgccggaag ccatcacaaa cgcggttccc aacattgctg ttaccattgt 1226821 catcaaaaaa gccaagccgg ttaacgtttt ttctgcgctt gcaaacgcga tccaaaaccc 1226881 gccgaaggct gctatcgagt ttgatatgat aatgcccggc tttgcaagtt tgataaaatc 1226941 gtaaatggtt acccggttcg aagcttttat gtattttgtt tcagatatgg ctgcagaatc 1227001 tcttgtattc tccaaaaata gacgcctccc ccaaaactgc atgcttttgt tatcgtaaca 1227061 agagggggac agaatcacaa ttatttccca tatttgtcat gatattgtca tttttaaaac 1227121 aaaaaaatgg ggagctggac tgcccccatt ttgatatgtg gcgactagta accgtaacct 1227181 cccccatatc ctccgccata acctccgccg taaccgtacc aagggtagta aggcggtcgc 1227241 gggcgcgggt agtaataagg cgggcgcgga taaaacgggt agaacggata atacggtctt 1227301 ggataataat aaggcggata aaatggcggt ctcggacgcg gataataata aggctgtctt 1227361 tcatcataag gggtaatttg ttcaaatgac tgttcattca aagggtaatc caagaggaaa 1227421 acctccctag ctttttttat tccttttacc atattcctga tgcttaagtt gggtgtatgt 1227481 acattcatga aattcggttt tttttatgat gaaattcctt aaaaaggatt gacatgaact 1227541 tctaaatctc atagtattac aaatgtgaaa taaatgttac tacaatgtta caaaaacatt 1227601 tctaaataga tacagttcca actgatgaag agtaaatcga aatggctacg aaagaaggag 1227661 tttttgttgt tggcaaaaag aatcaaatgg tttcatgtat taatagcagt tgtatgtgtg 1227721 gtgggcctta tcggcttttt ccataatcat tcattgaaaa aagaaacggt catgaataaa 1227781 gtaagaactg attctcaata tgggaatgtt gagatcgcaa cgcttgtgaa tgacgggaaa 1227841 acttttaatt acgcggtaaa ctatcctgtt ttcaaaaatg aaaaaatgga ttcggcatta 1227901 aaaagattcg cagaaaaaga ggttcgtcaa tttcaaaagg aaacaaagga cgttgaccaa 1227961 gagcatacga caaaacgcaa cgaattaaat gttgattata aaattgtcca ttatgccaaa 1228021 cagacagtgg cgattgtatt taatgaatat aaatacatcg gcggggcaca cgggcaaacc 1228081 gtgaaaaaaa cgtttaacta tgattttagt aaacaagcgt ttctttccat tgatgatatt 1228141 ttcaaagagg acgctgacta cttacataag ctttcgttaa tcgcttatca cgagctgaaa 1228201 aagaataagg acattgccgc ggacgatgca ctgttaaagg aagggacggc tccgaaaaaa 1228261 gaaaatttca gccgctttgc catcaaggag gattatatcg aactttactt tgacacatat 1228321 caggttgcag caggctatct tggagagcaa tcgattgcca ttaagaaaag tcttttgaaa 1228381 gacattctga aagaacaata tattgataaa gcaaaaaata aaaataaaat caaagaacaa 1228441 aagccgaagc atgaagtgat ttctttaccc aaagaggaaa cagttgatcc aaatcaaaaa 1228501 gtcattgcgc ttactttcga cgacggcccg aatcctgcga caacaaatca gattctagac 1228561 tccttgaaga aatataaggg tcatgccacg ttttttgttt tggggagcag agttcaatat 1228621 tatccggaaa cgctaataag aatgctgaaa gaaggaaatg aggttgggaa ccattcatgg 1228681 agccatccgc ttctcacaag gctttcagtg aaagaagcgt taaagcagat caatgatacg 1228741 caagacatca ttgaaaaaat aagcggatat cgtccgacgc ttgtaagacc cccatacggc 1228801 ggcattaatg atgaactgcg gagtcaaatg aaaatggatg ttgcgttatg ggatgttgac 1228861 ccggaagatt ggaaagaccg taacaaaaaa acaattgttg accgtgtcat gaatcaggcg 1228921 ggagatggaa gaaccatttt gattcacgat atttaccgca cctctgctga tgcggccgat 1228981 gaaattataa aaaagctcac cgatcaaggc tatcaattgg tgacagtttc tcagcttgaa 1229041 gaggttaaaa aacaaagaga agcgaaataa attagaaaag gctgtccgta cggacagcct 1229101 tttttctatt taataagagc ctgtggtggc ccaaacattt aagtttggtc ctgaatactt 1229161 gccgaaagcg taagaagtcc ttggatctaa atcatatacc atcggtgtat agcaagactt 1229221 ttggccggcc accgcttttc cattgccgcc tgcagaatca caattatatc tttttccgtc 1229281 tgtgttccgg gtaatctccg catttgcttc atagccagac gtcaatgtat tattcatcgt 1229341 gatttttgcc caagccgttt tacatgtact gctgaattta agctcgacta ctccgatgac 1229401 ttgattgctg gcattcacta agtttgagga tttttttgta gagccgctgg acgcacaatc 1229461 attgtaataa gggctttttc catcgtaggc atgggtttcc gccttggcgg gtgcaccttt 1229521 gacggcaaaa acaaatacta ctgcgaataa caccaatgaa gccttcataa acagtctttt 1229581 caatttatga cctccttaat atggcaaaca ataaatcata tggaggaaca atcaaaacat 1229641 gcatgctttt ttgtgaacaa taaaggcggc cgggaggatg gagttcttgg ccgcctctgg 1229701 tatgaggtta tgcttttaca tcaatggttt gtccgagagt tggatgttga atcatcttta 1229761 aggtttgatc ggcattttgc tgggcggtgt ccagcctttt tttcgttaaa gcaatattta 1229821 cattctgggc aagggatgct tgatgcatcg caaccgataa agcaggaata tccatggttc 1229881 cacctcctat gccttaccta tcggcgggtt tgtatgattt tacagtgaaa aatggcttaa 1229941 tttctcttgt tgacccttac gctgcggcat atcgtatgtt tttgacaagg agggaatcag 1230001 gatgaatcta gtaatggaaa agacctttga gcaatacgaa aagctgtttt caatggaaga 1230061 acagaaaaga gaagatgtat ttcggtatac gatgatgagg ccgtttgaaa agatgtggac 1230121 cgccatccaa gttccgctga aagcgaagga gccaaacggc tatgatgtga tcatggctgc 1230181 gaaaatgctg ggctatttgg atgtccgtga tgctgaaagc ggccagaaag cactacaaat 1230241 actgaaagaa tcacatgttt cagagacagc tgaatctgca cttcggcaat gcatattttt 1230301 tgctgagcgc gaacagctgc gggtgaatgc aaaggagatc aaattcggcc tttatatcgc 1230361 tgatccaaat aagcttcagc tgcaaaaagg ctactgcggg tttggcggga taccgggctt 1230421 tattcatgta tggattaatc cgaacagtta taacctgcca aggattcctt ccattattgc 1230481 tcatgagttt catcataatg tgcggttttc gtatatagat tttcatcatg gctctgtaag 1230541 tgtcggggat tatcttgtga ttgaaggatt ggcggaatca ttcgccagag agctgtttgg 1230601 tacggaacga ttgggccctt gggtaactcg ttttgatcat gaagacttgc aatattccat 1230661 tgatgtgatt aatgaggtgc tggatgtgaa aggattttcg gaagtcagcc gttatatgtt 1230721 tggtgatcca attgctaacg accaaggctt taagcctgca ggtttatcgg cttttgcggg 1230781 ttatgcagtt ggctatcatg ccgttcagtc atttatgaat caacatcata tcacgataag 1230841 cgaggccaca cgtttggatg cgaagaccat tatttctcaa tgcggtctgt tttctacatg 1230901 aaaaaagcgt cacatacagc ggcgcttttt gattcccaaa accagcagtt ctatggcggc 1230961 acaggcggca attccgattg tatatgcttc gatatcgctc cataaaaaac cgtaccctag 1231021 tacaagcccg ccaagagaag tatctctaat ctggtcgatc cattcggcat gatagagctg 1231081 gctgaattca atgacaaaac agaaagaaag actgataatg cccgttatca ttgtcttcag 1231141 cttccgaaat agaaatccgc atcccgtgaa gatcatggcg gcccacaacg agtctcccag 1231201 ataagtattg agggtatcag gaagaacact ggagaatgct ctggatccaa gccccagccc 1231261 aatgatcagt atggtgaaaa ctgcatatat ccaacgattt cgcttcattg cgaattgata 1231321 ccccgtctct gcttcatctc cctgtattgt aaggaatata gcttttattt gtccactaaa 1231381 aaagcggctg aatagccgcg tagggtgttt attttgcttt taggtttaca tggtcggctg 1231441 tctgatccgt gcctattaca aaatggagtt catagcggcc tgtatcatat acataatcga 1231501 tttcatcggt aaacgggacg gttaacaccc gatttactgg tcctaattgc ttctgcagca 1231561 cttccggcgt aactccgcct aaattcagct gccgttccac accggttcca aagtagcgga 1231621 tttctgaaat tgtcatgtct ttatgatagg aaaatccgta gcccggctgt cccatattcc 1231681 agtgatataa atcaaatcga ttgtctcccc cgactggtct ttccggttcc ccaaacgcag 1231741 cgtggacatc cccttttgtg cttttgttaa tggtaaggcc ttgcgcctgc tgaggcattt 1231801 cccctttata ggcggtgtta tagaggtttt tgacaagctc agcggctgat tgattcgtgt 1231861 tttctgagag tgtgtttgtt tgagctgcgg cctttgccgg tgctgaaaag gacgcagccc 1231921 caaagccggt aaaacagctt gttactgctg ctgccgcggt tatagcagac attgtctttt 1231981 tcatgttaat ccctcctaat tgatctacca ttccgtttcc ccgtgttttt gcaacgaaac 1232041 atgtgagtgc gctttgtatg ttttattgag ttgttgtaag ggaactgaaa taggtaattc 1232101 ggtatataaa gcaagaaagg ggaatggaga tggctggcaa gaaaacaatc acaataaacg 1232161 gcgttgaaat ggaagcgtcc gaggaacaga cggtgctgca gcttttgaat aacagctcga 1232221 ttgaagtgcc gcaagtttgc tatcatccaa gcttagggcc gattgagaca tgtgatacgt 1232281 gcatcgtcag catcaatggt gagctgaaga ggtcgtgctc cgctgaatta aaggatgggg 1232341 atgtcattga tacgctctca cctgacgtga aaaaagcgca ggtcatcggg atggacaaga 1232401 ttttatataa tcatgagctt tattgtacag tttgcgatta caacaatggg ggatgcgaaa 1232461 tacataatac ggtgaaggaa atgaaaatca atcaccaaag cattccgttt gatcacaagc 1232521 cataccataa ggatgaatcc catccgtttt atcggtatga tccagatcaa tgtatattgt 1232581 gcggacgctg tgttgaggca tgccaagacg ttcaggtaac tgaaacgctg accattgact 1232641 gggagcggaa acgcccgcgc gtcatttggg ataacgacgt gccgatcaat gagtcgtcat 1232701 gtgtgtcatg cggccattgt tcaacggtct gtccgtgcaa cgcgatgatg gaaaaaggaa 1232761 tggaagggga agccggatat ttaacaggca tcaataacga aacgctgcga ccgatgatcg 1232821 agatcacgaa aggcgtagag acaggctacg gctcgattct cgcgatttct gatatggaat 1232881 cggccatgcg tgatgaacga atcaaaaaaa cgaaaaccgt ctgcacgtat tgcggcgtcg 1232941 gctgcagctt tgatgtctgg acaaagggca gagacattct gaaagtagag ccgcaggagg 1233001 aagcgcctgc caacggcatt tctacttgtg tgaaaggcaa gttcggctgg gatttcgtta 1233061 acagcgaaga acgcctgaca aagccgctga tccgtgaagg cgatcatttc cgtgaagcag 1233121 agtgggagga ggcgttattg ctgatcgcca gcaagttcac tgaattaaaa gaggcgtttg 1233181 gcccggattc tctcgctttt attacatctt ctaaatgtac aaatgaagaa tcctatctta 1233241 tgcaaaagct ggccagaggg gtcattggca caaataatgt ggacaactgc tctcgctatt 1233301 gccaatctcc tgcgactgcc ggcctgttcc ggacagtcgg ctatggcggt gattcaggat 1233361 caattacaga tatcgcgcaa gcggaccttg ttttgattat cggttcgaac acgtctgagt 1233421 cgcatccagt cttatccact cggattaaac gggctcataa gctgagaggg cagaaagtga 1233481 tcgtcgcgga tatcagaaag cacgaaatgg cagagcgctc agatttattt gtccagccgc 1233541 gtgccggatc ggatatcgtc tggctgaatg cgatcgccaa atatttaata gaaaacggca 1233601 aggccgatga acgatttttg agagaaagag tgaacggacg ggatgaatat gtaaaaagcc 1233661 tcgcgccgta cacacttgaa tatgctgagg agaaaaccgg gattgatcaa gaaaccctta 1233721 tccaaatggc agagatgatc gggcaagctg acagtgtgtg cgcattgtgg gcgatgggcg 1233781 tgacacagca tattggagga agcgacacga gcacggcgat ctctaatctg ctgcttgtga 1233841 caggaaacta cggaaaaccg ggagcaggtt cttacccatt gcgcggccat aacaacgtgc 1233901 agggagcaag tgactttggg agtatgcctg acagactacc gggctatgaa aaagtgacgg 1233961 acgaacaagt ccgccaaaaa tacgagcgtg tgtggggtgt gccgctgccg aaggagccgg 1234021 gtatgaccaa ccacgaaatg attgaaaaaa tccattccgg acagttgaaa gcgatgtatg 1234081 taaaaggtga agaaatgggc cttgtcgact ccaatatcaa tcatgtacac gctgcatatg 1234141 aaaagcttga tttctttgtg gtgcaggaca ttttcctttc acgtacagcg gagtttgctg 1234201 atgtggttct tcctgcgagc ccgagccttg aaaaagaagg aacgtttaca aacacagaac 1234261 gccggattca gcgtttgtat caggtatttg aaccgctggg tgaatcaaag ccggattggc 1234321 agattattat ggaggttgcc aataagcttg gcgccggctg gctctatgag catcctgcag 1234381 acattatgga ggaagcagcc aagctgtcgc cgatttatgc cggtgtcacc tatgaacgtc 1234441 ttgagggcta taattccctg caatggcctg taaacgctga tggaaaggat tcgcctttac 1234501 tctttacaga gcgcttccct ttcccagacg gcaaggccat tctctaccct gtccagtgga 1234561 cagagcctaa ggaattcggt gaggaatatg atatccatgt caacaatggg cggctcttgg 1234621 agcacttcca cgaagggaac ctgacttaca aatcaaaagg gatttcggag aaaacaccgg 1234681 aagtgttctt agaaatttct cctgagcttg cggcagaacg agggattcag gacggaaccc 1234741 tcgtcagact cacatcgcct ttcggaaatg tcaaagtgaa gtgcctgatt actgatcgag 1234801 tcaaagggaa ggaagtatat ctgccaatga acgattcagg ggaagcggcg atcaacctgt 1234861 taacaggcag ccatgccgat aaggataccg atacgcctgc ttacaaagaa acatcggcca 1234921 agatggaaat tttgaagcac gacggaatca gcccgctgcc taagatcaac caccgcaacg 1234981 gcaatccgca gccgcaaatc ggtgtgcagg ttcataagaa atgggcgcgg aaggattata 1235041 ttttccctgg tgacgctgtg aaaaggggga tgggccataa tggctaaagc gattaaacga 1235101 atccaaaaaa tcgaggtaac agaagaggat cagcgaaagc gtgatttgcg ggaaattgaa 1235161 gatgctctaa ttgaccacaa agaagcgatt ctcgaaacat tgcatatgct gggccatatg 1235221 aacgagcgcg gggtcctgcc gttgctccgc ggcctttttg gtcaagggga taaagttctt 1235281 gatatcctgg tgaaaaaggc agatacagag gaaacagcca atacgctgaa aaatctgctt 1235341 cttctgtttg gaacactcgg catgctggac gtgaagcagc tggagcctct cattttgaaa 1235401 gtgaatgcgg gtgtggcaag cgctgtagag cagaaaaaca gtgaagaaaa gacaggttat 1235461 tttgatatta tccgctcgct aaaagacccg gaaatcaaca aatcaattac actgctcttt 1235521 tcctttttaa aaggaatggg acaagataca aaggagctgg aacgcacgac gcagcctccg 1235581 gaacaccaaa aacatcatca ggaaccccga gagaaaagag gaatgaataa gcgagattga 1235641 cctcccaccc gagcggcttc agccagctcg ggttttttga tgaaaaggtc taatggacta 1235701 gtaaaaaata ttcaaatact aggaagaagt aagattgtga tgaatgagat agaaataatc 1235761 gttactttct tacctgttaa gaaaagggaa aatctgatta taatagaaat cgattacttt 1235821 agatggggga acaatcatga aaaaagtctt attactatta tttgtcttga cgatcgggtt 1235881 agcgctttct gcgtgcagcc aatcgagcga tgcgtcagag aaggaaaaac cgaaagagaa 1235941 aaaatcgcaa gaagagcttg aaaaggaact tgataaggaa ttgaaaaaag gcggtgagcc 1236001 gaagaccaaa aaagatgatc aaatacataa aataggagaa acatttaaag caggacatac 1236061 gaattttaca gtgaataaag ttgatagagt gcaaaaaggt gaatatatga atgttggcgg 1236121 agctgtaaat gaggagacaa aaacaataaa agatgatgag gaacggctta ttatagaagt 1236181 tacgatggaa aatatagggg aagattcaat aagctacaat tttatcgggt ttgatttaag 1236241 agataagaat gatcaatcag tgcggcctgt tttttctata gaagagaagg gcagaatcct 1236301 tatgggagga acactagtat cggggaaaaa ggttacaggt gtactcagtt atgtcatccc 1236361 taaaggagaa cagaaacatt acacactggt atataatccg tttttagctg atacaaatag 1236421 cagtaataca gaagagagag taaaggacga tattgattac ttggtgaagt tagattagat 1236481 gctaatttac agttgcacgt ttttcatctg tggaaaacgt gcatttttta tagcgaaact 1236541 tgacttgaaa ggatgagtga taaaagtgca aaccaaatgg ctggaacggg cacagcggat 1236601 tcgggcgatc gcccaagcgg ggcttgcttt ttccaaggat gtgtacgaca gggagaggta 1236661 cgaagagcta atgaagctta gcgcggaaat gatggcggat tactcggaga aggacattga 1236721 agttatcact gatttatggc aaggcgagaa gggctatcca acaccgaaag cggatgttcg 1236781 cggcgctgta ttcagagaga atcagatttt gcttgtccgg gagaagcatg atgagctgtg 1236841 gtcgctgccg ggcggatttt gcgagattgg tttatcgccg gctgaaaacg ttgtcaagga 1236901 aatcaaagaa gagtcggggt acgatacaga gccgtctcga ttgctggccg tgctagacag 1236961 ccataaacac tctcatcccc ctcagcctta tcactattat aaaatcttca tcgcatgcag 1237021 catgacggac gggcaggggg aaacagggat cgagacgaat catgccgctt tttttccgga 1237081 agacagactc ccgccgcttt ctcctaaacg aaacacaccc tcacagctta gcatgctgtt 1237141 tgactttttg cgccatccgg acaagaaaac gatatttgac taaaaaagaa agagcctgtg 1237201 ggctctttct tttttataat gtaatgtgtt tttcgttggc gagtttcaga agggtcaaaa 1237261 tagaatcggc ttgtttatgg ccgagttttt gctttaattt gttttcttca actaatcggc 1237321 tgccataaat tttgacggag gctttgtcga cgacagtatg ccagttttcc tgtttttttc 1237381 cctcaacaag cggtttttca tgtctctcag aaaaagagaa cacaaagagt acgaatgcaa 1237441 gtgaaagtag gattccgaca acttgttttt tgtaatcagt ctgtgctgcc acgttgttct 1237501 ctccttcacc ttttaccttc tatttaatca tagaaccaaa ttattttaca taatgggaaa 1237561 gtcatttttg gagttagtgc atttggttga aaacagagac gttttttgag cggagcggtg 1237621 caattgaatc catattggat ttgcgtgctt atgcctaagg tcacgttgtg agccaaaaca 1237681 gcagtgcaga atagaaaaaa attgaaagat tatggtaaga tgaacgaaat tcgaggggga 1237741 atatatgatg cctgcatcga acatcgtgat cgcctgcctg ctgttatcaa tttaattatt 1237801 tgtggtagtc cctctctttt tcgaaagcgg gaggtgaagt ggaacattaa ttgctgaatt 1237861 ctttcaaggg gagtgaccgt acatgaatgt gttaaaccgc cggcaagcct tgcagcgagc 1237921 gctgctcaat gggaaaaaca aacaggatgc gtatcatccg tttccatggt atgaatcgat 1237981 gagaaaggat gcgcctgttt cctttgatga agaaaaccaa gtgtggagcg tttttcttta 1238041 tgatgatgtc aaaaaagttg ttggggataa agagttgttt tccagttgca tgccgcagca 1238101 gacaagctct attggaaatt ccatcattaa catggacccg ccgaagcata caaaaatccg 1238161 ttcagtcgtg aacaaagcct ttactccgcg cgtgatgaag caatgggaac cgagaattca 1238221 agaaatcaca gatgaactga ttcaaaaatt tcaggggcgc agtgagtttg accttgttca 1238281 cgatttttca tacccgcttc cggttattgt gatatctgag ctgctgggag tgccttcagc 1238341 gcatatggaa cagtttaaag catggtctga tcttctggtc agtacaccga aggataaaag 1238401 tgaagaagct gaaaaagcct ttttggaaga acgagataag tgtgaggaag aactggccgc 1238461 gttttttgcc ggcatcatag aagaaaagcg aaacaaaccg gaacaggata ttatttctat 1238521 tttagtggaa gcggaagaaa caggcgagaa gctgtccggt gaagagctga ttccgttttg 1238581 cacgctgctg ctggtggccg gaaatgaaac cactacaaac ctgatttcaa atgcgatgta 1238641 cagcatatta gaaacgccag gcgtttacga ggaactgcgc agccatcctg aactgatgcc 1238701 tcaggcagtg gaggaagcct tgcgtttcag agcgccggcc ccggttttga ggcgcattgc 1238761 caagcgggat acggagatcg gggggcacct gattaaagaa ggtgatatgg ttttggcgtt 1238821 tgtggcatcg gcaaatcgtg atgaagcaaa gtttgacaga ccgcacatgt ttgatatccg 1238881 ccgccatccc aatccgcata ttgcgtttgg ccacggcatc catttttgcc ttggggcccc 1238941 gcttgcccgt cttgaagcaa atatcgcgtt aacgtctttg atttctgctt ttcctcatat 1239001 ggagtgcgtc agtatcactc cgattgaaaa cagtgtgata tacggattaa agagcttccg 1239061 tgtgaaaatg taatagataa ggagactgga gattcatgaa aaagtaccat atttcgatga 1239121 tcaatatccc ggcgtacgga catgtcaatc ctacgcttgc tttagtagag aagctttgtg 1239181 agaaagggca ccgtgtcacg tacgcgacga ctgaggagtt tgcgcccgct gttcagcaag 1239241 ccggtggaga agcattgatc tatcatacat ccttgaatat tgatcctaag caaatcaggg 1239301 agatgatgga aaagaatgac gcgcccctca gccttttgaa agaatcactc agcattctgc 1239361 cgcagcttga ggagttatat aaggatgatc agcctgatct gatcatctat gactttgttg 1239421 cgctggctgg taaattgttt gctgaaaagc ttaatgttcc ggtcattaag ctctgttcgt 1239481 catatgccca aaatgaatcc tttcagttag gaaatgaaga catgctgaaa aaaataagag 1239541 aagcagaggc tgaatttaaa gcctacttgg agcaagagaa gttgccggct gtttcatttg 1239601 aacagttagc tgtgccggaa gcattaaata ttgtctttat gccgaagtct tttcagattc 1239661 agcatgagac gttcgatgac cgtttctgtt ttgtcggccc ctctctcgga gaacggaagg 1239721 aaaaagaaag cctgttgatt gacaaggatg atcgcccgct tatgctgatt tctttgggta 1239781 cggcgtttaa cgcatggccg gaattttaca agatgtgcat caaggcattt cgggattctt 1239841 catggcaagt gatcatgtcg gttgggaaaa cgattgatcc agaaagcttg gaggatattc 1239901 ctgctaactt taccattcgc caaagtgtgc cgcagcttga ggtgttagag aaagctgatt 1239961 tgttcatctc tcatggcggg atgaacagta cgatggaagc gatgaacgca ggtgtgccgc 1240021 ttgtcgtcat tccgcaaatg tatgagcagg agctcactgc aaatcgggtt gatgaattag 1240081 gccttggcgt ttatttgccg aaagaggaag tgactgtttc cagcctgcag gaagcggttc 1240141 aggctgtatc cagtgatcaa gagctgctca gccgcgtcaa gaatatgcaa aaggatgtaa 1240201 aagaagctgg cggagcggag cgtgcggcag ctgagattga agcgtttatg aaaaaatccg 1240261 ctgtcccgca gtaaaaacat aaaaaccgaa atcaatttga tttcggtttt ctgtttaaat 1240321 attttttttc atcccgcatc tccggcattc tctaagaaat tttccgcctt ttacagagct 1240381 tttgaacagt gtgtaatcac agttgtcgca gcgcccgctg cgggcatccg gatattcatt 1240441 gaattcgtaa acaatcgatg tatcgtagcc ttttgtttca tattcttctt ttttggtttc 1240501 catgtcgatc ctccgttaca agacgtgtct gctgtttatc ttacagcaag cttccggcgt 1240561 attcaatgga ttttaggagg ttgggtttat cttgatttct cccttggttt gcgccaaaat 1240621 agctttatta agcttatata cataaaaagc ctatgcaaag aggagaggaa acgggtatgg 1240681 gaaaagggtt acttggaaaa cgcgtggcaa tcggtggctc acgaaaaacg gaagaaatta 1240741 gtacaatcat tgaaaaacag ggcggaatac ctgtcatccg gcctctccaa ggtacagttt 1240801 acttagcaga gaagcaggtg gagccggatt tgcggacgtt tgcggaagaa aaagctgact 1240861 gggtcatttt cacgacaggc atcgggttgg agactcttgt cgatatggca gagaaaattg 1240921 gactgaaaga tgagtttctg caggccattc gccaagcgaa agcggcatgc cggggataca 1240981 aaacgctgtc tgcgctgaaa aagcttggaa tcacaccgga agcttcggat gaagacggga 1241041 caacaagagg cttaatccgt tccttggagc ctcacgactt ttcaggaaaa acagtcatgg 1241101 tgcagcttca tggcgaaaaa gcgccggctc tcatggcatt tcttgaagaa aaaggcgcgt 1241161 ctgtcctgcc gattctgcct tatcagcaca tcccgccgga ggaggaaacg gtggagcggt 1241221 tatgccgaga gctgatgaac gatgaggtcg atgccgtttg ttttacaacg gccattcagg 1241281 ttcgttccct gtttgatttt gccaaggggc gaggttatat caatgaagtg aagaaggtat 1241341 tcgaagaacg cgccatcgca gctgctgtcg gaaaagtgac tgctgaagca ctgcgggaag 1241401 agggcattac gagactgctt gcgccagaga ttgagcggat gggtgcgatg attgttgagc 1241461 tggccaagta ttatgaagaa aaggaataac aagtacaaaa agccgctttt ccctcggaaa 1241521 gcggcttttg tctgtcattc attttgcttc agctgctgat gaacggtgaa taatgatggg 1241581 tatgtcagca cgcttaagat tacacaagtc agcgcggctg aggccatcgt tgtaaacacg 1241641 attaagagtt gaaagcgtac tgcctgaatc gggtccgcgc cggctagaat ctggccagtc 1241701 atcatgccgg gaagctggac aagacccagt gttttctggc tttcgagcgt cgggatcata 1241761 ctcattttca tcgctgaggt aagaatgcgc tgtatggatt gcttcggtgt gccgccaagt 1241821 gacaatatta attgaatttc ttctttgcga acgccgactt ctgagttaag ccggtttaga 1241881 aacaaacttg agagcaccat cgaatttccg atgaccatcc cgctgatcgg aatgacatat 1241941 cgtgccgtaa gcggaatgat atgaagagac agcagaattc cctgcgtcac aatttctacg 1242001 attgctaacg cggcaaacac cctccaaaac gaaccgatag tatttttctt tcgcttgatg 1242061 acattttgcg ccgccaccgc gagcattaac agcaccatca gcaggataaa aacagggtgg 1242121 tctccgcgaa aaatcagcga caaaacataa ccgatgataa gcagctgcac cgcggcccgg 1242181 atggtggcga tgatcatgtc tttttctaca ccggctttaa aggattttga taaaaacaag 1242241 gcgatcaaaa caaagatcat cgttaaagag agagaaaggt aatccattac cgagtgcctc 1242301 ccttcaaaaa ttctttcgct gcttcatgct gcggagcgga gaaaaatgtg tcggtttcag 1242361 cgatttcaag cagccggcca tctgccataa accaaatggt atcggctatt cgttttgcct 1242421 gctccatatt atgagtgacc cacatgactg tccatttttt ctcttgatgc tgacgtttga 1242481 tcagttcttc aatctcaaga gcagagaccg ggtccaaggc cgatgtgatt tcgtccaaca 1242541 atagaatgga ggaaggattt gagagcgttc tggccagtga cagtctttgc cgctgcccgc 1242601 ccgataagtc tctggcgctt ctgtctaaca actctggcgg cagccctgca agcgaagcca 1242661 gcttttcagg agagtacagc tgggattgat gcagcctttg tacaagactt aaattgtcac 1242721 gcactgtccc gtcgagcacg ggagccgatt gaaacgcgag ggctgccgtt cgcctcagct 1242781 cattgacatt ccattctctg acttcctttc cgtatatgtt gacttcgccg ctgtcaggcg 1242841 ttctcattaa attacacata gaaaggaggg tgcttttgcc tgagccggaa gggcctaaaa 1242901 cggctacgat tgcaccctgt tgaatgtctc cggtgacatc ctgcagcaca tcataggttt 1242961 gtccatcttg tttatagctt tttctgactg atctgaagga gatggctggt atgttttgtg 1243021 tttgatcgtt tgcttccatt acaataatca cctttcaata taagtaggct gacattatat 1243081 ttaactataa cgtgaaacag attccttttg gtagcacaaa taaaggagaa caggctttca 1243141 cccattctcc tgcagatgct acgcagtcag atttgactgt gctttctttt tcggttttct 1243201 cggctgtgaa gcgaaggtat gtaacatcat ccccgctatt ataatgaaca aaccggcaaa 1243261 tgataataga gatgggaaaa cgcctgacag cagaacaatt tcaccaagca gcgcgaaaat 1243321 cacttcaccg gattgagtgg cttcaacagc tgcgagtttt tgcggattgt ctcttaccat 1243381 atcagtggcc cagaaaaata aaaccgtcgc aatgatgcct gagctgacgg caacgataaa 1243441 ggattgaacg gtttgacttg ctgttggaag gccatctgac caccagccgt aagctgctaa 1243501 tataagccag aatggaaggc ttgccaatgt cattccaagc acgcgctgaa atgtatcaag 1243561 ccggcctccg tattcttcga gcattcttcg gtttcctaac ggataggcaa aagccgcaat 1243621 gacaaccggc agcacactga aaagcagcat cctcccagaa agcgattctg catgctgaag 1243681 ctgaatcaga gccgctccaa tcaggatgat cacagaagtg ccaagtgaaa ccaggggaat 1243741 cttttggcga atgagctgcg gaccgcccgg catatcttgt ttgacataaa acaaaggaga 1243801 taagagcacc ccggctacaa ttgtaatttg ccaggttcca gctatgagcc accccggacc 1243861 gtatgcagcc gcaaatgtaa tcggtgcgta aaaaagcacg aaaccgacga agctccattt 1243921 gatccaataa aacggctttt tcctcatttc tagtaagaga ggcgtgaatg tccctctcat 1243981 gatgacaatc aaacataaaa atggcaccat aaaaataaag cgcagcgaag agctccaaag 1244041 ccagctgcct cctgataact ccatcgctct gtttaatata aaggtaacgg cgaaaaagag 1244101 tgaagccaat attccgataa cgatagcttt catgatatcc ctcattctgg cattattttt 1244161 ttatactata ctattcggta tcatgcagat caatggaatc atgagaaaaa catcatgttt 1244221 ggcgaaccgc tatatgtgga agacaaaaaa gggaggtgaa attgatggaa agagagacac 1244281 agacatactt ctttccggat gacggcagga ttccgaatca ccctgatttt ccgctcgtgg 1244341 tgtatcaaaa cgcgcttaag gacaccggac tggcagagcg gatcgtcacc cggcatggct 1244401 ggtcaaacag ctggtcaggg agtgtttttc cataccatca ttatcacagc aatacgcatg 1244461 aagtcctgat tgcccttagg agagaggctg tgattcagtt tgggggagaa aaaggggctg 1244521 ccatcccttt caaatcaggc gacgcagtcg tgattccagc cggagtcgga cataaaaagc 1244581 tcagctcaag ccccgatttt actgtccttg gcgcctatcc cggtggcgtt cagtacgata 1244641 tgaagacggg gaagccgaat gagcgggagg aagcggtcaa acagattaag caggcggcgt 1244701 tgccggcgaa tgatccgatc acaggaaaaa gagagcctct attggaaata tgggtaaagt 1244761 gaaggggaga aattgctgga ttgtcaataa ctagtgccgc agaaacgata tgacatgagc 1244821 tccatataaa ttaatttcat aatcgaagca attcacgttc aaattttgtt caaaaagtgt 1244881 tatcatatag aaggtaatcg aattggagtt ttttgtgttt gctattttca gagagagtaa 1244941 aggattttga cttattcaat tgtttatttt tagataaaaa taatactgaa tatggcaaga 1245001 tgaaaaactg ggtagtaaac atttattttt gtaaatgatt gtgcatgaat tcacaatcct 1245061 tattcttatg ccttaaaagc gtgagacagg gagaggcact accctttcca aaaaaatcag 1245121 caaactgctt atagtaaagg agaattggat atgccagaaa caatcgatca aacaaatgcg 1245181 tctgtcagcc aaagccagca agatcttatt gatcagctat taaagccaga agttcaagaa 1245241 tcattgactg ttttagttga ccagcttccg aagctgactg agttagtgaa tattttaacg 1245301 aagtcttatg atttcgctca gtctgtagcg actgacgaag tgttaaagag cgacacagtc 1245361 ggtgcgatca ctgaaattct cgagcctgta aaagaaacag cgaaagaagt agctgcgact 1245421 gcgatcgaag caaaagaccg cgcggaagca agcaacgaaa caattggact tttcggcctt 1245481 cttcgcatgc tgaaagatcc tcaagctcaa aagctgttcc gttttgctaa cagctacctt 1245541 gaagtcatga acgaacgcga aaaccaaaaa taatctcaga ttcaaattga tataaaggac 1245601 ggaggatata cgatgtcaaa acatattgtc attctaggcg ctggttatgg cggagttctt 1245661 tctgctctaa cagttcgcaa acattacaca aaagaacaag cacgcgtgac agtggtaaac 1245721 aaatacccaa ctcaccaaat cattacggaa ttacaccgcc ttgctgcagg caacgtgtct 1245781 gaaaaagcgg ttgcaatgcc attagaaaaa cttttcaaag gcaaagacat tgatcttaaa 1245841 attgcggaag taagctcttt ctctgttgat aaaaaagaag ttgcgcttgc tgacggttct 1245901 acattaactt acgatgcgct tgttgtaggt cttggttctg taacggctta cttcggcatc 1245961 ccaggtcttg aagaaaacag catggtattg aaatctgctg ccgatgcgaa caaagtcttc 1246021 caacatgttg aagatcgtgt gcgcgagtac tctaaaacga aaaacgaagc agatgcaaca 1246081 atccttatcg gcggaggcgg cttaacaggt gttgagcttg ttggtgagct tgctgacatc 1246141 atgccgaacc ttgcgaaaaa atacggcgta gaccataaag aaatcaaatt gaaacttgtt 1246201 gaagcaggtc cgaagatcct tcctgttctt ccggatgatc ttatcgagcg tgcgactgca 1246261 agccttgaaa aacgcggcgt tgagttctta acaggtcttc ctgttacaaa tgtagaagga 1246321 aacgtaatcg atctgaaaga cggatctaaa gttgttgcca acacatttgt ttggactggc 1246381 ggcgtacaag gtaacccatt agtcggtgaa tcaggcctag aagtgaaccg cggacgcgcg 1246441 actgtaaatg acttcctgca atctacatct catgaagatg tattcgttgc tggagacagc 1246501 gcagtttact tcggtccaga cggccgtcca tacccgccaa ctgcacaaat cgcatggcaa 1246561 atgggtgagc tgatcggtta caacctattc gcttacctag aaggcaaaac gcttgaaaca 1246621 ttcaagccag taaactctgg tacacttgca agccttggac gcaaagacgc ggttgccatc 1246681 attggtgcta attctacacc gcttaaaggt cttcctgctt ccttgatgaa agaagcaagt 1246741 aatgtacgat atttgacaca tattaaagga cttttcagcc tggcttacta atccttttaa 1246801 tgaatctggc attgccaaaa gcattccttt ccgagtgctt tctggcaatg tcttttttta 1246861 tgtttatgac agcgttaaca tttcattttc aaaaaagaga ttgatcccaa aggaatataa 1246921 aggtaaaata aaaacaaatc aaaatgttaa cgttaacatt ttgaaataga atgaaagacg 1246981 gtgaggacat ggaacccttc atgggcaaaa actttttatt gaaaaatgaa accgctgtca 1247041 gcctctatca caattatgcg aaagacatgc caattattga ttaccactgc cacttaagtc 1247101 cgaaagaaat ctatgaaaat aagacatttc aaaacatcac ggaagcctgg ctgtatggtg 1247161 accattataa atggcgcatc atgagagcca atggaattga ggagacatac attaccggag 1247221 atgcgcctga tgaggagaaa tttatggctt gggcgaaaac cgtgccgatg gcgattggca 1247281 acccgctcta caactggact cacttagaat tgcagcgttt ttttggcatt tacgagattt 1247341 taaacgagaa gtccgggtcg gctatatgga aacagacaaa taaactgctc aaaggggaag 1247401 gcttcggggc aagggattta atcgtgaaat caaatgtaaa ggtcgtgtgc accacagatg 1247461 accctgttga ttctcttgaa taccatttat tgttaaaaga agacaaagac tttcctgtca 1247521 gtgtgctgcc tggatttcgg ccggataaag gacttgagat caatcgtgaa ggctttcctg 1247581 agtgggtgca ggcgcttgaa gatgccgctg ccatatcgat tacaacctat gatgagtttt 1247641 taaaggcgtt ggaaaaacga gtgcgattct tccactcagc cggcggcaga gtttctgatc 1247701 acgcgataga tacaatggta tttgccgaaa caacaaaaga agaagctgga cggatttttt 1247761 ctgacagatt acaaggaaca gaggtttctt gtgaagatga gaagaaattt aagacatata 1247821 cgcttcagtt tctttgcggt ttgtatgcgg agctcgattg ggcgatgcag tttcatatca 1247881 acgctttaag aaacacgaat acaaaaatga tgaaaaggct cggacctgat acagggtatg 1247941 attcaatgaa cgatgaagaa attgctaagc ctttatacaa gctgctgaac tcagttgaga 1248001 tgaagaacca gctgccgaaa acgattttat attcactgaa tccaaatgat aactatgtca 1248061 tcgccagcat gatcaacagt tttcaggacg gtattacccc gggaaaaata caattcggca 1248121 cagcctggtg gtttaacgat actaaagacg gaatgctcga ccaaatgaaa gcgttatcaa 1248181 atgttggcct tttcagccgt tttatcggca tgctcaccga ttccagaagc tttctttcgt 1248241 atacgcgcca cgaatatttc aggcggatcg tctgcaattt gattggagaa tgggtggaaa 1248301 acggcgaagt gccgcgcgat atggagcttc tgggaagcat cgttcagggg atttgctatg 1248361 acaatgcgaa acactacttt caatttcaag aagagaaagc aaacgtgtaa caaagtgtcc 1248421 gctcagtatc gctgagcgga tcactatccg aaaattctta agacacagag gtggaacatg 1248481 cgaactgaac tggcaaataa ggttgtgtcg gtcgaaacgg aaaaaaggct ttcattgaaa 1248541 gagaaaatgt cctatggctt tggtgatttt ggcaacggtt ttatgtttga tctcggccag 1248601 atttatttat tgaagtattt cactgatgta gcgggaatcc ccgctgcgat ggccggcggc 1248661 atttttttag tcagtaagct gtttgcagcg ataacagatc caattgtcgg ctcatcaatc 1248721 gattatcgca aaaacatcgg caaacggggg aaattcaggc cttatctatt aatcggcagc 1248781 atcgtgcttg cggtgcttac tgttcttatt tttctgtctc ccaatgtatc aacgaccgga 1248841 aaactgatat atgcatatgc atcctatatg atttggggca tcggctattc gtttgtgaat 1248901 attccgtacg gctcattagg ggcagcgatg actcaaaatt ctgaggaccg gacctccatt 1248961 tcgacgttcc gccaaatcgg atcacttggc gccttgttta tcacaagtgt ggccgtgatg 1249021 ccgctgctcg tcaagtttga taatccgaag gtcggctacc cggtggtcat gggcttgttc 1249081 gccgcgctcg gtgtgttttg gttttatatt tgctaccgca actgcaaaga gcgcattatc 1249141 atatcggaag cacccaaaga aaaattaaca ctctcatctg tcgtcaaaac atttattaca 1249201 aataaaccgc tgttaaccct tgtcctgatg acgatttttt caatttccgc atacaacatt 1249261 aaatccgcca tgctcgtcta tttcgcacaa tataacttgg gcaatgttga attaatggct 1249321 tatatgaact tcatcattat tggttcttcc tttttgggcg tcgtattcct tccaaagctc 1249381 gtcaagatgt ttggaaagaa acgaacggca atgatcggct ttggcatcag tgtggccgcg 1249441 gatctgatca actttatgct tccatctaac gtttatgtgt ttacaattct cgccagtatc 1249501 gcctttatcg gaatcagtat cccaaatggc atcacgtggg ctcttgtctc cgatattatc 1249561 gactatggcg aatggaaatc cggtgaacgg aaggaagcaa cgacatattc acttttcaat 1249621 ttctcaagaa agcttgctca atctttgtct ggctttctct cggggatcgg tttggggatt 1249681 atcggctatg tgccgaatgc agtccagaca gcacaggcgc tgattggcat caaagcgctg 1249741 cttcttctgt atccggccat tgctttggca ttagcgatgt tcattatcgg ctttctttat 1249801 aaactcacag accagcagca tgctcagatc gttcaggatc ttcatcaaaa gagctgacaa 1249861 tataatataa agaatattta aaataatttg taaataaaat gtgtttgtag gggtttcgct 1249921 tggagagtgc ccaaaaaact gaaaaggaag gaggcacttg cttgaaaacg ataacaattg 1249981 cagctgaaga agcaaaggaa ctcgtttggc aaaagctgga cggtgccggt ttgaatgaac 1250041 gagatgctga aaaagtggca gatgttctcg tgcacgctga tttgcgcaat gtacattcgc 1250101 atggcgtgct gcacacagaa cactatgtga acaggctttt agcgggaggg atcaatcctg 1250161 gggcacagcc tgtttttaaa gagacggggc ctgtgaccgg ggtgcttgac ggagacgatg 1250221 gtttcggtca tgtgaattgc gacatggcga tggaccatgc aattgacatg gcgaagaaaa 1250281 aaggagtcgg catggtcacg gccgtaaaca gcagccattg cggagcgcta agctattttg 1250341 tgcaaaaagc ggctgacgaa aagctgatcg gaatggcaat gacgcataca gacagtatcg 1250401 ttgtcccatt tggggggagg actcctattt tagggacaaa tccgattgct tacggagttc 1250461 cggctaagca taaaaaaccg tttatcctag atatggcgac atccaaagtg gcttttggga 1250521 agattctgca ggcccgtgaa gagggcaaag aaattcctga aggatgggga gtcgatgaaa 1250581 acggagaagc agtaactgat cctgacaagg tcgtctcact ttcaacattc gggggcccga 1250641 aaggctatgg actatcgatt gtagtggatg tgttttccgg attgctggcg ggcgcggctt 1250701 ttggccctca tattgccaaa atgtacaacg gccttgatca aaaaagaaag ctggggcatt 1250761 acgtttgcgc gatcaatcca tcctttttta ctgactggga tacgttttta gagcagatgg 1250821 atgccatgat tgatgaactg cagcaatcac cgccggctgt tggattcgaa agagtgtatg 1250881 tgcccggcga gatcgagcag ctgcatgaag aaagaaataa gaaaaacgga atttctatcg 1250941 cccggagcgt gtatgaattc ttaaaaagca ggtgagtaaa atgaaagcgg ttcaagtgcg 1251001 aaaagcgtat gatctggtga cagcggaggt gaagaagcca gttctttcaa aggatgatga 1251061 agtgctcgtg aaagtcaagc gagtcggcat ttgcggttca gacatgcaca tttatcatgg 1251121 aacgaatccg ctcgctaccc tcccgagagt catcggacac gaggtaacgg gacaagtgga 1251181 ggcagttggt gcgaatgtac agagcctaaa acccggtgat catgtggtga ttgagccgat 1251241 ttcttattgc ggatcgtgct atgcctgccg caaagggcgg ccgaatgttt gcgccaagct 1251301 ttctgtattt ggcgtacatg aggacggagg catgcgggaa tatattgtgc ttccggaaag 1251361 acagcttcac gcggtctcaa aggacttgcc ttgggaggaa gcagtcatgg ccgagcctta 1251421 tacgataggc gcccaggcag tgtggagagg ccaggtggaa aaaggtgata ccgtcctgat 1251481 ccagggagcg gggcccatcg ggatctgtgt gttaaaaatg gcaaaactgg cgggcgctgc 1251541 tgtcatgatg actgacttga acaacgagcg gctggcattt gcgaaagaaa acggcgccga 1251601 tgctgttgta aatgtccaag cagaacatgt tgccgagcgg gtccttgaat ggactgggaa 1251661 tgaaggagca aacgtggtca ttgatgctgt ttgcctgccg gagacttttg cactttcaat 1251721 tgaggctgtg tcaccggcgg gacatgtggt tgtgcttgga tttgatgaaa gagcggctca 1251781 gatttctcag ctgccaatta caaaaaaaga agtcacgata accggatccc gattgcagac 1251841 caatcagttt ccaaaagtgg tagagctttt gaatggaggc cggttaatgc ataacgggct 1251901 ggtgacccat acattttcag ttgatgacgt tcatcatgca tttcagttta ttaaggagca 1251961 tccagatcag gtgcggaaag ccgtcatcac gtttgattaa atgactgaat ccggaggtgc 1252021 gagcatgaat atgacattcc gatggtatgg acgaggcaac gatacagtca cacttgaata 1252081 cgtgaagcaa attcccggtg tcaaaggcat cgtttgggct ctccatcaaa agcccgtcgg 1252141 cgacgtgtgg gaaaaagaag aaatcagagc cgaaactgaa tatattcaat cctatggttt 1252201 tcatgctgaa gttgtagaaa gcgtgaatgt tcacgaagcg attaaacttg ggaacgaaga 1252261 acgcggccgg tatattgaaa actacaagca aacgatccgc aaccttgccg gatttggcgt 1252321 gaaagtgatc tgctataatt ttatgccggt ttttgattgg acacgcacgg acatgttccg 1252381 gccgctagaa gatggatcga ccgctctgtt ttttgaaaag gccaaggtgg aaagccttga 1252441 tcctcaagag ctgattcgga cggtggagga agcatccgac atgacactgc cggggtggga 1252501 gcccgaaaaa ttggctcgga tcaaagagct ttttgctgcc tacagaacgg tcgatgaaga 1252561 aaagctatgg gacaatttat cattcttttt gcaggaaatt cttcctgttg ctgaggccta 1252621 tggtgttcaa atggccattc atccggatga cccgccgtgg ccgattttcg gactgccgcg 1252681 cattatcaca ggagaggcaa gctataagaa actgcgggcg atatcagatt caccgtctaa 1252741 ttgtatcacc ctttgtacag gttcaatggg agccaatccc gctaacgaca tggtggagat 1252801 cgctaaaacg tatgccggca tcgctccatt ttcacatatt cgcaatgtga aaatttatga 1252861 gaatggcgat tttattgaaa catctcattt aacaaaggat ggttcgatca acattcaagg 1252921 cgtgatggaa gaactgcata agcaggatta cgaaggatat gtcagaccgg atcatgggcg 1252981 ccatctttgg ggcgagcaat gccgcccggg atatggctta tacgatcggg cacttggcat 1253041 catgtatttg aacgggctgt gggacgctta tgaagcaatg gcaaaaaaag aggtgggcat 1253101 atgatcccgc tgcatgagaa cctggctggt aaaacggctg tcatcactgg cggcagcggc 1253161 gtgctttgct ctgcgatggc ccgggagcta gcccgtcatg gcatgaaggt ggcgattttg 1253221 aatcggacgg ctgaaaaagg ccaagcggtc gtgaaggaga taacggcggc tggcggcaca 1253281 gcgtgcgctg ttgctgcgga tgtgctggac aggatgtcac tggagcgggc aaaggaagac 1253341 atccttggcc aatttggcgc tgttgatctg ttaattaacg gggctggcgg caatcatcct 1253401 gacgcgataa ccgatgtgga gacatatgaa gaagcgggag aaggccaatc cttttttgat 1253461 atggatgaga ggggctttct aactgtattc tccaccaact tcaccggtgc gtttctggcc 1253521 tcgcaagtgt ttggtaaaga actgctgaag gcggattcac ccgcgatcat caacctttct 1253581 tccatgagtg cttattcacc tatgacgaag gttccggcat acagtgctgc gaaagcatcc 1253641 atcaataatt ttacgatgtg gatggctgtt cattttgccg aaaccgggct gcgggtcaat 1253701 gcgattgccc caggcttctt tctgacaaaa caaaatcatg atctgctgat caaccaagac 1253761 ggaacgttca ccagccgatc tcacaaaatt attgcgggaa caccgatgaa gcgcttcgga 1253821 aaaccggagg atttgctcgg tacgctcctt tggctggcgg atgaatccta ttccggtttt 1253881 gtcactggga tcaccgttcc tgtcgatgga ggatttatgg cttattcagg tgtgtaacga 1253941 aagcggtgca acagaaactg aaccaacata ggggtgaggt tgagatgttt tcaaaagata 1254001 agcttcccgt tatccttttt ttgttcctgg caggggtgat taattacctg gatcgctcgg 1254061 cgctttccat tgcagctcct tttattcagg atgatctcac attgtctgcc acacaaatgg 1254121 gcttgatttt cagcagtttt tcgataggtt atgccatttt taattttctt gggggcgtgg 1254181 catccgaccg ctatggggca aagctgacct tgtttgtcgc gatggttgtt tggtcgctgt 1254241 ttagcggagc agtcgccctc gcttttggct ttgtcagcct gctgattata cgcattctct 1254301 tcggaatggg agaaggcccg ctttcggcga ccatcaacaa gatggtgaac aactggttcc 1254361 cgccgaccca gcgggcgtcc gttatcggtg taaccaacag cggcacgccc ctcgggggag 1254421 ccatttccgg cccgatagtc ggcatgatcg cagtggcgtt cagctggaag gtatccttcg 1254481 ttctcattat gattattgga ttgatatggg cagtgctctg gttcaagttt gtcaaagaaa 1254541 agccgcaaga gacgatcaag gaagcaccgg caataaaagc agaaacgtct cccggagaaa 1254601 aaattccgct caccttttac ctgaagcaaa aaacagtcct gttcacggcg ttcgcttttt 1254661 tcgcttacaa ctacatcctc ttcttctttt tgacatggtt tccgagctat cttgtcgacg 1254721 agcggggatt aagtgttgaa tcgatgagtg tcatcacggt cataccgtgg attttaggat 1254781 ttatcgggct ggctgcgggg ggatttgttt ctgactatgt gtacaaaaaa acggcccgaa 1254841 aaggtgtgct gttctcgcgc aaggttgtgc ttgtcacgtg tttgttttca tcagctgtcc 1254901 tgattggttt tgccgggctt gtggcaacga ctgcgggggc tgtcactctt gtcgctctgt 1254961 cagtgttctt tctttatttg accggtgcta tctattgggc tgtcattcaa gatgtggttg 1255021 atcaaaacaa tgtcggttct gttggcggct tcatgcattt cctcgccaac acggcaggaa 1255081 ttatcggccc ggctttaacc ggatttattg ttgaccaaac aggcacgttt tctggagcat 1255141 ttttgcttgc cggtgggctg gctgtcttcg cttcacttgc tgtgattcgt tttgtccgtc 1255201 caatcattgg taagccagcg ggaacagaag ctgagaatcc tgtgtcttat taatctggaa 1255261 atatagtggg agaggcggta tgtttgatga tacaatatac agtaaataat cgcagccggt 1255321 atgataagga agggaattag atggtaacca taaaagatat cgcaaaactc gcaaacgtat 1255381 cccacactac tgtttccaga gcactcaaca acagccctta catcaaagaa catacgaaga 1255441 aaaaaatatt agagctagca gagcagctca actatacacc aaatgtaaat gcgaaaagtc 1255501 tggcgatgca aaagtcgcat acgatcgggc tattctttac aagcattaca aacggaacct 1255561 cacacagctt ctttgcagac actatcaaag gcgtcaatca agccataagt gaggattaca 1255621 atctgtatgt gcgcggcatt gatgatctga aaaactatga ctccgttaca ccgatgagat 1255681 atgacggcat cattttaatg agccaaagtg acattgataa ttcttttatt taccatattc 1255741 gcgaaaaaaa cattccgctt gtcgtgctga atcgtgatat tgatgatcgt accatcacga 1255801 atattttgtc caatgacaag gaaggctctc aagaagctgt agaatacttc attcagtccg 1255861 gacatcaaga catcgccatc atcgagggga tcgaaggctt taaatcctcc cagcagcgaa 1255921 aggaagggta cttatccgca ctgattcaac atcatattcc gatcaagcat gaatacagtg 1255981 tcaaaggaca gtacgatatg gaaagcggct ttcaagcgat ggagcggctg ctggcactgc 1256041 cgaatcctcc aaccgctgtt ttttgttcga atgatgacat ggcaatcgga gcgatgaatg 1256101 cgatattcgc aaagggcctg cgcgttcctg atgatatttc ggtgatcggg tttgatgata 1256161 ttgggttttc acagtacatc acgccaaggc tttcaacagt aaagcgccca gtggagaaaa 1256221 taagcgtgct cggtgcgcaa aaactcttgt cgctgatcag cgagcccgaa acaaaagcag 1256281 aaaaaatctt ggaaaacaca gaatttatgg tgcgtgattc agtcagacga ttgacgacgt 1256341 gatgtcccgt ttttcagcgg gcattcttta tacagaaaaa tgttaacgtg tgcataaagt 1256401 gagagggagg caataagggt gcagaagctg aataaaaatg tgtacgatca ctatactcag 1256461 tatccagaaa aaattctcca attcggagaa ggaaactttc ttcggggatt tatcgattgg 1256521 cagattgatc aattgaatca acacactgat tttaatggga gcgtggcagt tgtccagcca 1256581 agaggctcag aaaaaatcaa acgattaaat gagcaagatg gattatatac acttttttta 1256641 caaggaatga aagacggaga agcggtaaac gagcatatga ttatcaactc aatcagccgg 1256701 ggaattgacc tgttttctga ttatgaagca tacaaagaat tggcatcaag cgaaaggctt 1256761 cggtttatta tctccaacac cactgaggct gggattgtat gtgatgaaaa agatcgttta 1256821 gaggataggc cgcaaaaaac attccctggg aaattaactg catttcttta ctttcgctat 1256881 caggctttta aaggagatca gacaaaaggg tgtgtcctga tcccatgtga actgatcgag 1256941 aataacggtg aaaagctgag ggaaacggtt cttcattatg cacatctgtg gaagctggag 1257001 gaaggattta cacagtggat tcatgaggcc aatacatttt gtaatagttt agtagaccgg 1257061 attgttccgg gttttcccgt cgacagcatt gatgagatca cggcagatct tggctatcag 1257121 gatgatttga tagttgtggg agagcaatat tatttgtggg ttatcgaggg gcctgattgg 1257181 attggaaaag aacttccctt tgcggctgca gggctgcata caaagatcgt cagcgacctc 1257241 accccatacc ggactaaaaa agtaagaatt ttaaatggcg ctcatacagc aatgacgcca 1257301 gtggctttat tatacggctt gaagactgtt agggatgcag tcgagcatcc ggaagtgggg 1257361 cgatttataa gagagctgat tgatgacgaa attcttcctg ttttaaaaat ggaaggtctt 1257421 tctcagtatg ctgacgatgt gctgaaccgt tttaaaaacc cgtatattaa gcattacctg 1257481 gaaagcattg cattgaacgc catttccaaa ttcaaaacga gaaacctgcc gactcttaag 1257541 gaatatgctg aacaaaaggg acagcttcct gaacgcttgg tgttttcttt cagcgctctt 1257601 ctgtattttt atcatgataa cgagacattg caggatgatc cggcagttct tcaatttttc 1257661 aaagaggttt ggtgtcagga ggatggcgac atgcttcgga ttgcatcaag agtgttaggc 1257721 gaacagcggc tgtggggggc agatctcaat gagataccga agctgactga tagagtcgct 1257781 gtttacttga atcatattca tgagctgggc atgcagaggg ctcttgaaca atactgcata 1257841 caagggggag aggtacgttg aagtcgttta taaagattca taagcaagat aatgtccttc 1257901 ttgctctgcg ggatattcaa aagggagaga ggctgcatgc ttacggcgtg tcgattgaag 1257961 taaaggatga tataaaaaga ggccataaga ttgcattgca gtctatcaaa gaaaacgaca 1258021 gcatcgtcaa gtacgggttt ccaatcggtc atgcatcaca agatatctcg atcggagagc 1258081 atattcatgt ccataatacg aaaacaaacc tgtctgatat ccaattatac agctatacac 1258141 cgagatttga tgaaaatccg tattctaatg agaaccggac gtttaaaggt tttagaagag 1258201 aaaacggaga tgcgggtgta cggaatgaat tgtggattgt cccaactgtc ggctgtgtca 1258261 atggaatagc agaaaaaatg ctgcagcgtt ttgtcagaga aacaggggat atcgctccat 1258321 ttgataacgt actggtgtta aagcatcaat acggatgctc gcagcttggc gacgatcatg 1258381 aaaatacgaa gcagatcctg ctgaatgcca ttcgccatcc aaatgccggc ggcgtcttgg 1258441 tgttagggct tggctgtgaa aacaatgagc tggcaagaat gaaggaagca ctgcaagatg 1258501 tgaacttgaa gcgggtgaag tttctggaat cccagtcggt gaccgacgaa atggaggcag 1258561 gcgttgcttt gctgaaggaa attcatgaag cggccaaagg agataagaga gaagacattc 1258621 cgctgtctga actgaagatc gggctgaaat gcggaggttc ggacggtttt tccggcataa 1258681 ccgcaaaccc gctgcttgga cgtttttcag attatctcat tgcacaggga gggagtactg 1258741 tgctgacgga agtaccggaa atgttcggcg cagaaaccat cctgatgcag cgggctgcca 1258801 atgaagaagt gtttcataag atagtcgatt taatcaatga tttcaaacaa tactttatta 1258861 aacatgatca gccggtgtac gaaaatcctt caccgggcaa caaagcgggc ggcatttcta 1258921 cacttgagga taaatcgctg ggctgtacgc aaaaagcggg gatttctcct gtcacggatg 1258981 tcttgaaata cggtgaagta ctcaagacaa aagggctgac tcttttgagc gcaccgggca 1259041 atgatttgat cgcctcctcc gcattggcgg ctgccggctg ccaaattgtc ctctttacaa 1259101 cgggaagagg cacgccgttt ggcacctttg tcccgacggt gaaagtagcg acaaacaccg 1259161 agctgtatga ggcgaagccg cattggattg attttaacgc aggcctttta gcagaggatg 1259221 atgttcatga ggaatatgtg ctgcgtgagt ttatccacta tatgattgag gtggcaagcg 1259281 gccagcttgt gaaccatgaa aaaaatgatt tcaaagaact cgccattttt aaatcgggtg 1259341 tgacgttata ataagaaaag gctatccttc aagcggatag ccttcttcat taaatcaatt 1259401 ttaaaccgct gactaaaata atggaagcca taataaattg cagtggacgc ggggagaatc 1259461 gaggcgaaag atggctcccg atcagtacgc cgggaattga accgaggagc agattagctg 1259521 ccagcatgta atccacgctt ccgaagcttg cgttcaaaat gcctgctgcc gtaacaagaa 1259581 gaaaagcatg cgcgatatcg gttccgacaa tctgtgacgc tttcatgtta aataagtaaa 1259641 tcatggcgat tgcaaataat gagccggacc cgattgatgt taatccgacg ataaacccaa 1259701 acacaacacc aataagaatt gtcagcgccc tcttattttc aagcggcatc agctgccagc 1259761 ggttggggcg aagttttcta tccaaaaaca aacgaacgat gattgaaatg gcaaccagcg 1259821 ttaacacata tcctagagcg tgcttaataa tttcttcctg atgctggtga aaggcgggga 1259881 acaaatgcaa tatgccaatg gctagcgaag cactcggaat accgccgatg gctaagtatt 1259941 ttaccaattt aaagttaatc gttttctgcc gccaatggga ggcaacgcca aacagctttg 1260001 tgatcgagtt atatacaaga tccgtaccga ccgcgatgga aggattaatt ccaagcacaa 1260061 ttaaaagggg agttaataag gccgctccac ccactcccgt caatccgact aaggctccga 1260121 caaacaaacc catcaatatg atgcttacac tcatgataaa ggcctcctga aaacccgact 1260181 agaattcacc cgaatcttat tcgcgttggt caagtattaa ttgtaagtgc tccatcggct 1260241 gctgaaaaac ccgagctcta tccgctccct gatggtatca ttcaattgac aacaccttat 1260301 acatcaggag aacacgtctt tcaggtgcaa cgagcacttg cggctctgta tttttaccct 1260361 gataaaggcg ctgttaacaa cggaattgac ggcgtttacg gaccgaaaac agctgacgca 1260421 gttgcccgtt ttcagtctgt taacggtcta actgctgacg gtatctacgg gcctgcgacg 1260481 aaagagaaga tcgcagcgca attaagctga tcaaagacca taaaaatccc ggagccgctc 1260541 cgggatttat tttttcttct tcaacttttt tataattcca gcactgcgct ccctcacccg 1260601 aagcgagtac ccggaaagcc caaaccttcc gtaatcaaca aacttcacac gcctcaccaa 1260661 ttttttcact gtatcacctg acattatcct ctgtttgtat ttattatatg tcacccttta 1260721 agaaaaggaa taaggacaag agctgttttc ccttgtcctt ttagtgtgat catgcttttt 1260781 ttcgtttata ctcgtcaatc agccgttcgt tttctttgaa gattcttgct gtatgcggac 1260841 tgacttgata gcttgcgaca ctggtggttg aacgtttttt caggatttta aacggcttcg 1260901 ccgctctggg ctcgcatctg ttttgaaacg cacgttccat tatccttcac cttcctcctc 1260961 aattggcagc accaaatcat atatgctcgt taatgacgta aatagcaaat aatcaaattc 1261021 cgtgacaatg ctgtcagacg tcagcttgat gacatagttc tgtgtctcga tggtaaaagg 1261081 gatgagaacc acttttccgt attggtcgta ataaacatcc tttcgatcga gccgtgtttg 1261141 tacatctgcc ggatcatcca tatgctcggt taaccggtct ttatcagcct gtgtcgaata 1261201 gtggcaaaga gaagccgtta agttcatttt atcagcatag gttttcagca gcttatcaat 1261261 accttcagca taagcatcta tacttccata ataaacatgg atcggttcgt ttttcaatag 1261321 gtattggtat gttttcagcc gattgagata catgtggagc atttcgttgt tttcttcaag 1261381 aatttctctt gtgtctgttt caagctcgct gccggccagt tttttgacat atgcacttaa 1261441 gaagataaaa gcatcaatca aagcaaaact gactgcgaca atgagatacc gttcccagtg 1261501 ggtaaatagg gaagtgggct catatgtcca gtataccata gcgcccagaa caaacagcaa 1261561 ataccaagtt ttccgaatgg cggacatttt ttctttgacc ttcgcttcga aacgccacgt 1261621 ggcatacacg tataacccca gtccggccac gatgcaccag accatgatct gaaagaataa 1261681 aaccatattc gaatccctca catctgaaat aggttctgct tattgtattc gagagatccg 1261741 gatggttttc ctgttccatc aaaaaaaccg ctcctttgac agaagcggtg tgacattaaa 1261801 atatcatatt taaaataaag taggcgatgg caccaagtgt cgctgaaatc ggaagcgtga 1261861 tgacccatgt aatgagcatt cgcttggccg taccccagtt tacgcctttt acgcggtggg 1261921 acgcaccgac gccaagaatt gatgaagaaa tgacgtgggt tgtactgacc ggcaaatgaa 1261981 taaacgtggc gccgaaaata atggctgctc cggttaagtc agcggaaaca ccgtttaccg 1262041 gacggatttt catgatcttt ccgccaacgg ttttgatgat tttccagccg ccgattgatg 1262101 ttccgagacc catggctgtc gcgcaggcga attgcaccca ggtaggaata tcattagcag 1262161 aagtatgtaa attcgctgtg atgagagcca ttgtgataat tcccattgct ttttgcgcat 1262221 cgtttgttcc gtgtgtatac gattgcaggg cagctgttac aatctgcact ctgcggaatt 1262281 gcttattcgt tttcgccaag ttgctgtctt tgaaaatcag cttaacgatg ctataaagaa 1262341 taaaaccaag gacaaaggca ataattggtg atagaatcag tgcttcaatg attttaatga 1262401 agcccttata gtttaacgct gcaaatccgg ctgccgcaat ggctgcaccg gcaatagcgc 1262461 cgatgatggc atgggatgag ctgcttggga taccgtagta ccatgtgata aggttccagg 1262521 caattgcagc gagtagcgca gccaaaatga caacagagcc attttccagc gtataaggat 1262581 ctacgatgtc tttcgtaatg gttttggcaa cacctgtaaa cgtcattgct ccgacaaagt 1262641 tcatcacagc agccaatata atggcatggc gcggttttaa cgcttttgtt gataccgaag 1262701 tcgcaattgc gtttgccgta tcatgaaacc cgttgatgaa atcaaacgcc agagcacaaa 1262761 tgactattag tatcgttaat attaatagaa tatccatttt tacccctcgt tacgcgtttt 1262821 tcataatgat ggtttcaaga ttattggcaa cactttgaca agagtcggcg atttcttcaa 1262881 gcgtttcgta tatttcacga tattgaatga ctttgattgg atctgtttca tttccgaaaa 1262941 gattctttaa tgattttctg tgcaagttgt cacaactgtg ctcatactct ttaattttga 1263001 ttgcgtgagg ctgaatatcc tttaagcgat tttctgccag cagctcgatc gtaatcaaaa 1263061 tctctttcgc acattctctg atatatccgc tgaatttatc aatatgctcg tctgatgaag 1263121 taattgagaa aatctccatc atggcagaga aatgttcgat tccgtcaagc acatcatcca 1263181 agctgtttgt cagctgaagg atatcttcgc gctcaatagg agtgatgaac gctttgttaa 1263241 gctctttaat catgacatga acatgattgt caccttttgt ttcatattcc tttaacgtat 1263301 ctgcaaattc tttaagagtc gtttggttag tgaccttaaa attcacaaaa tattctgcag 1263361 tttcgtctat gttctttgca atttctgtta aaaggagtga gaacttatct ttttttcttc 1263421 ttatcattaa aaaccctcca tagtttgaat gaacaatgca cacatcaaat tattatatag 1263481 ccttttgtcg aaaaaaaaca ggtaaagtcg aaaaaaacgt atcttgactt ttttgataaa 1263541 tcgtgtctcc ttattttgac ctacttcgct ttaaaaaaac gacccaagtt tgcaaaaact 1263601 ttctgcttaa cgtaaaaagt atatcaaaag ttgtgttttt cctgtcaact tttatcttct 1263661 gtttcaccaa aaaacggttc cctaaacaag ggaaccgttt tatcagcttg cttttcgttt 1263721 tttcatcccg taataaacag gcagtccggc aaggccgatg aggatggata atccgcagct 1263781 cattgtatct gtaatgagtg tgctgcctaa cacaaagaag gagcccgcga ttgccagaat 1263841 tggcataaat ggataaagcg gaacactgta ggcgcgcttt tctccctttg ctcgcttgcg 1263901 gagaataaac actgcaaaaa aggccatcac ataaaaaatg tagatcatga aaatggagat 1263961 ttctgagagc ttatcagggt tgctgatcag catcataatc aaagccaaag caatttgaaa 1264021 agaaatcgca atccatggtg tgcggaacga cgggtgtaca tgtgacagtt tttcagcaaa 1264081 tggaagctgt ttgcgttccg ccattgcaaa tgaaacacgc gggaaagaaa gcacctttcc 1264141 atttaagcac ccaaagatgc tgacgataat ccctacactg atcagctttc cgccaattga 1264201 accgaacagc atggttgcag cggtgcttgt cgcattttca ccaagcgtga caatttcgtt 1264261 cgctgacagg atgtgaagca atgcaaaatt aatgaaaata tagatcgccg ttacaattaa 1264321 taatccgccc gtcatagcgc gtggcagcag cttttcggga tttttcattt ctccgccgag 1264381 agcggcaagg agaatccatc cgtcataagc aaacaacgta gctaaaatag ccgccccgaa 1264441 gttcatatca gaaatgcttt cgtttactgc tgtgaagatg tgctgatcgc ctttccaaag 1264501 gccaaagacg atgatgcagg caatcggaat cagttttccg atcgttgtca gcgtttggac 1264561 aaaaccgccg tattttgtac cgataatatt aatgacgcat aaaaagagaa ctgctataat 1264621 tccaatgact tttgatagtc cagatcccca gccgaaaaga ttcgccatta aagatccaaa 1264681 atataaaccc agcgcgccaa taatcgccgg gccgtaaatg ataatctgca cccagccgca 1264741 caaaaatccc caaaactcgc cgtacacttc ttcaaggtac gtataaagcc cgccggtttt 1264801 tggaatctgc gttccgattt ccgcgattgt caaaccgccc gccagtgtta aaataccgcc 1264861 taacagccag gcgaaaagcg ccatttttga atcacctgaa taagcaagca cagcgccggg 1264921 cttcataaaa acaccagaac cgataatggt tccgatgaca agagtaaggg caaacaagag 1264981 gcctatctct tttttcaaac cgttgtcttc agtatgcatg tccttaacct cctatgatgt 1265041 tgaagcttca tgttgaagaa tctatttttt catattgtaa accctatttt agaaaagtga 1265101 aataaaataa attttctgat tttcgaaatt tgctttgtgt acagcagata aaactgtaga 1265161 aatacctgtt ttaatggtct ataaacgaat aaaattcata atttttattt acaaagttcg 1265221 tgttttatgt attaggattt tagccggtac agaggggaga tgagaattca gaaaatgaac 1265281 gaaccttcgg tgaagctgat atgttgactt tctcatgcga ataaaatact ttgttattag 1265341 aacaataaat atacaattat gatatgatat ctcgaaatcg agataaaata acctggaggg 1265401 acagcatatg aaagttaacg gcattcacca cgtatcggca ttaacggccg acgcacaaaa 1265461 aaacttggat ttctataaga aagtattagg attaaagctc gtcaaaaaat ccgtcaatca 1265521 ggatgaaccg acaatgtacc atctgttcta cggagatgaa gtggcaaacc cgggaactga 1265581 gctgacgttt ttcgagattc cccgcattgc accgtttcat gcgggaacaa acagtatttc 1265641 ttctattgga ttgcgcgttc caggcacaga agccctgcat tactggaaag aacgttttga 1265701 agagcagcaa gtaacgcaca gcggcatctc caaaagagcc ggacgtgaca tattggcatt 1265761 tcaagatcat gaggggcagc gacttgtgct gactgctgat gaggaaggaa aaggatatgg 1265821 cctgcctgtt aaacagagcg gcattccgga agaattttcg tttcgcgggt tagggccggt 1265881 tgaactgact gtgccatatg ctgaaccaac tttacacgta ttgacgaata ttcttggatt 1265941 tacagaaatc agccgtgaac cagtcgaagg gcaaggaacc gccgttattc tggaatcagg 1266001 agaaggcggt gctgcaacgg aaatccattt aatagaaaga aacgatcttc cgcgagagcg 1266061 tcaaggcaaa gggagtgttc accacgtcgc atttcgggta agagatgaag aagaacttgc 1266121 cgggtggcac cggatcatca gccgcgaagg ctttagcaat tcaggcatag ttgagcgcta 1266181 ctatttcaag gcgctgtatt tcagagaacc gaacggcatt ttgttcgagt tatcaacaga 1266241 cggaccgggc tttatggtag atgaaaatct tgatgagctt ggccaaacga ttgctcttcc 1266301 gccatatcta gagcatcgaa gagcagaaat tgaagcaaaa ttgaaaccga tccaataaat 1266361 tgtgattctt ttgccttccg gcgccgccgg agggcttttt ttattaccat aattaatttt 1266421 gacctaaaca gcatgcctta ttagggagga aatatcagat gctgattggg agaaatggct 1266481 taaaaccctt tgcaaatatg ggtgattggt atggaatggc ctcggcaaaa atattgtctt 1266541 tgtttattaa tagtttattc atatttgctt gttacactat ttcaaagtta gacaaaaagg 1266601 agtgaaaaat aagtggaaaa gaaaaaacgc gagctggata tcgtcctcct cctcattttg 1266661 ctcgcatctg cattcttaaa tatctataac atttggaagg acgacacggt gaatccttat 1266721 tacaccgcgg cagttacaag tatgatgcaa agctttcata atttctttta tgcttcgttc 1266781 gatgctgccg gctttataac agtagataaa ccgcctgtta cataccaaat ccaaacgatc 1266841 agcgcactga tattcggtat gcacggctgg agcgtcatcc tgcctcaggc acttgctggt 1266901 gtaggttctg tccttcttat gtacttgctg ataaagccga catttggaaa aacggcggcg 1266961 cgtattgcct catttgttat ggcatgtacg ccgatagctg tagctgtagc acgtacaaac 1267021 aatgttgatg cattactggt atttttctta ttgcttgcta catggcttct ctttaaagcg 1267081 atcagaaaag gaaagctgat ctggctgtta gcagcatttt tcgttgttgg agtaggtttt 1267141 aatacaaaaa tgctgcaggc ttacatgatt ttaccggctt tcttattgtt ctatctgatt 1267201 gcggcaaacg ccacaatcaa gaaaaaaatc gtttcattgg taagtgcgtt agccgtatta 1267261 gcagccgttt cgttatcgtg gccgctcatt gttgacaata tccctgcaag caagcggcct 1267321 tatatcggaa gcagccaaac caactctgtt ttggaattgg ctttcggcta taacggaatc 1267381 cagcggctga caggccaaaa ttcaggcggc ggccagggtg cgccaaacaa agacgcttca 1267441 aaagaaatgt cttcttctga taacactcaa gcaccgccta atcagtcatc aagcaacagc 1267501 tcatcaagcg atggtaaatc ctcaaatggc aatatggcgg cgcctccatc caatggccaa 1267561 atgccaagcg gcggtcaagg aggccctcca agcggcggag atggcggcca aggcggaccc 1267621 ggcggagacg gagggaaagg cggtacagga accggttcga aaatgcaatc aggttcaggg 1267681 atgtttggaa cgggaacacc tggtccactg cggcttttcc aacaagagtt atctgatcaa 1267741 atcagctggc ttctgccatt tgcgatattt ggaatcgcag gcttactgat cgctggcgca 1267801 agagaaagaa gaagattatc tgtagagcag aaggaaacgg tgttctgggt tgcgtggctt 1267861 gtaccgattg ccggattctt cagtgtcgca gaatttttcc atcattatta tctcatcatg 1267921 ctggcaccgc cgattgcggc tcttgtcggt gcggggtggg tcgctcttgt tcatctgtac 1267981 cgcaatcaga caggctggaa agcatggctt ttgccgggag caattattgc gacaactgga 1268041 tttgaattgt ttattctcag aaactacaac gatcaaatcg gtgttggatg gagtatcggg 1268101 gtaggtgtta tcggcgtgtt gtcagcgatt gctttgctgc tgtttaaaca gcgccaaaaa 1268161 ccgttcagtt attatgtttc acttgcagct ctcctcgcat tgctggtgat gccgatgtat 1268221 tgggcaagta caccgcttct gtacggaggc aacagctcac tgcctgaaac aggccctcaa 1268281 ctcgcatcaa tgagcggaaa aggcatggga atgtctgatg cgactgtaaa tgaaaaactg 1268341 atcaaatatc tagaggagaa taactccgga gctgaatacc tattcgccac aaccgattcg 1268401 aacacagcgg caccatatat cattaaaacg aaaaaagctg tcatggctat tggtggatac 1268461 agcggttctg acccggcaat cacactgact caattcaaaa aacttgtaaa agaaggaaaa 1268521 gtgaaatact tcttggcttc tggaatggga agaggcggaa acaatgacat tgttgaatgg 1268581 gttgagaaaa atggaaaaga agtagcatca gaaaaatggc aatcaagttc tgatcaaaaa 1268641 acagaaaata ctgattcagc tgatacatca agcagcaagg cttcaggtga aaacggcaaa 1268701 atgggcggac ctggcggaat gaatcagtca gcaacattat acgaactaca tgctgatgaa 1268761 taggaggcaa aaacatgagc agacatattc aatattcaat tgttgtacct gtgtataatg 1268821 aagagcttgt cattcatgaa acctatcagc gcttaaaaga ggtcatggat caaacgaagg 1268881 aaaactacga gctgcttttt gtcaacgatg gcagcaaaga ccgcagtatt gagattttaa 1268941 gagagcacag cctgatcgat ccgagagtga aaattattga tttttcaagg aattttggac 1269001 atcagatcgc cattacggca ggtatggatt atgcacaggg gaatgcaatc gtcgtcattg 1269061 acgccgattt gcaggaccct cctgaactga ttttagaaat gattgaaaag tggaaggaag 1269121 gctatgaagt cgtgtacgcc gtacggacta aacgaaaagg ggaaaccttt ttcaaaaaac 1269181 aaaccgcggc tatgttttac cggcttctca gcggtatgac agatattgat atcccgattg 1269241 atacggggga ttttcgcctc atggacagaa aagtctgtga tgaaatgaag agattaaaag 1269301 aaaaaaatcc atttgtaaga gggctagtca gctgggtggg tttcaaacag acagcggtcg 1269361 agtatgtacg tgatgaaagg ctcgccggag aaacaaagta cccgctcaag aaaatgctga 1269421 agctgtcaat ggacggcatc acgacatttt cacataaacc gctgaagctg gcaagctatg 1269481 cggggatttt aatgtcaggt actggatttc tgtatatgtt tatcgtgctg tatctgaagc 1269541 tattcacaga cagcacgatt accggctggt catcacttat tgtgatccag ctcctgttca 1269601 gcggcattgt ccttctgatt ttgggcgtga ttggcgaata tatcggcaga atctacgatg 1269661 aagccaaaga caggccgctt tacatcgtcc aaaaatcgta tggaattgaa aataaaagac 1269721 tctatagaga ccagcatatg tcataacctc aaaccccctg tccgtaatgg acagggggtt 1269781 tttatgctct gagcacgatc taaagcaaaa gatgctgata gatatatgga aattgggtaa 1269841 agaagagatt gtgagcttgt actgcggttc agtcatgctg aaataaaaac agcaaaactt 1269901 aaagatttcg tcctcggctt tgctgcatgt cagctgttat attggggggc ttttaagaaa 1269961 cgcatgatta gagccgtacc agttatgttt aatagaatac tcgtacccaa tacaattccc 1270021 cacgtcaacg tcgattcaga gagaagaaag ctcagcaaaa gaaaagccaa tcctgcgcag 1270081 atcataccca gtcccacggt tttcatgttc atgcctccta gcaaacgatg tttctagcat 1270141 ctgatgtgaa tgatgtcaat ctgtatgata tacggatatc tcgtcagaaa gtttcataga 1270201 acaattaggt cttttatcta ataaaaagcc tcagaccgct tttacggcct gaggcattat 1270261 gtcttacgaa gttttctctt ctttttgatc cagtttaatt tttttcgtca tttctttgcc 1270321 gtttcggaga attttcactt caacggtatc accgatcttt gcgtctttat ataagatatt 1270381 gcgcaattca ctgcctgtat caatttcttt accttttagg ccgatgataa tatcctccgc 1270441 ttttaatccg gccttttcag caggagagcc tgaagcgacc tcacggatgt aaacgccttt 1270501 attcagctgg ctgccgaaca ggccgagtgt gccttcttgg taattttgcg gcacttgctc 1270561 tagatcaagc atgctgacac cgatatatgg acgttcaatt tgtcctttag acagcaattc 1270621 ttcagcaatc ggttttacgt cattgcttgg aatggcgaat ccgataccct caacatcatc 1270681 ctcactgatt ttcatactgt taatgccgac aattttgccg tctgtattta acaaaggacc 1270741 gccgctgtta cctggattaa ttgctgcgtc tgtctgaatg acgttaatgc tcgtttcgcc 1270801 ggctgatgta gacattgaaa ccgttctgtc cacgccgctt acaattcctt gtgttactgt 1270861 gcgggacagg tcttttccaa gcggatcccc aatcgcaata acggtctcgc ctgttctaag 1270921 atcagatgaa tcaccgaagt ttgccacttt tgtgacgtgg tcatcactga tttggaggac 1270981 ggctaaatca gttaacgagt cactgcctac cagctttgca gtaacctcag tgccgtcata 1271041 taaagatacc ttcagtgatg atgccccttc tacgacgtgg ttatttgtaa tgatataagc 1271101 cttgccattc tcttttttga aaatgacacc tgaccctgaa ccgctttctg tatcttcgct 1271161 ggaatcagaa gaactagagc cgaacaaaga gctgtttgat tgtgcctgaa gatttgtaat 1271221 accgacaatc gctggtgaaa ggtcttctac catatctgag attttagaag agtcctcgct 1271281 cttgaatgca gatgagctgc ttgagctttt tttagattca gaggaggtgc ttgttgctgt 1271341 aacagattgc gtttgctgct ggctggatga ttgttttgca gtgtcctgag aatcatggtc 1271401 accaagcggt gtaaacgtgt aaatgccaag agcaagactg ccgccgatca ctccgccaag 1271461 caacggtctg aaccatccga atcctcgttt tttcttctcc tgatcatgaa tgacattgcg 1271521 ggccgagtag gaggcgctct gatcgttctc tttcgttaaa aagacctcat tctcattacc 1271581 tttcgttctg ttttcatcac gatagttatc catcatgttc actccgtttc tctattttca 1271641 catgtctatt tatattgata ggtttatgac ttgagtttat cataaacaaa aactgtggga 1271701 taaaaatgaa aagattatgg gaaattgtga aaaagtgcgg aaaacggtac acttcatatt 1271761 gtatatgaaa ggactgagtc gatggaacag attggattga ttggatatgg cagcatggcg 1271821 gatatgatcg ctagacagct gttgaaacat gaacaaataa aagagaatga gctatttatt 1271881 gagacgagaa cgaaggggga gcggctgcgg gcactcatgt cagattatcc aaacgtatcg 1271941 gctgatccgt tggagaattg ggcaaatacg tgccaattga ttttgatatg cgtcccgcca 1272001 ctccatgtca tcgaaacaat gcgccgtctg tacccgtatg tgaacagaaa tactcacatc 1272061 gtatccatag ctgccggtgt gccgctgcgt cttttggagg cagaaacaga agccggtatc 1272121 tcacgtgtta ttcctgccat tacgtccgaa gcagaagccg gcatctcact tgtcgttcac 1272181 agtgaagcac tggctgcaga gaaaaaagaa cgtctgaatg aattgttatc ggttttcagc 1272241 cgtgtacggg aaatcaaaga atcgaattta gatgtggcca gcaatttaac gagctcggca 1272301 ccgggattca tagctgcaat ctttgaagaa ctggcactgt ctgccgtcag aaacagcagc 1272361 ctgtccaaag aagaagcctt tgattttctg attcattcgc tatacggaac tggcaagatg 1272421 ctgatcgaaa aaaatatgtc tttcgaggag acgctggaac gtgttgcaac caaaggcgga 1272481 ataacgggag agggagctga ggtgatacac gcctctgtgc cggacgtttt tgatgaggta 1272541 tttgaaagaa ccctgagaaa atatgaactg cttacagaac aggttggtaa acaaacatga 1272601 atccttgaaa gaggattctt tttttatcac tgaatgattg agatttttcc cagttatatt 1272661 gcatttttcc tcttttttta atataatttg ttagaatatt cataatttag taaaaaagga 1272721 ggagcgttat gaaattgtac atgtcagtag atatggaagg tatttcgggt cttccggacg 1272781 atacctttgt ggattccggc aagcggaatt atgaacgcgg acggcttatc atgactgaag 1272841 aagcaaacta ctgtattgct gaagcgttta acagcgggtg taccgaggtg ctggtcaatg 1272901 acagtcattc gaagatgaat aatctgatgg ttgaaaagct tcaccctgaa gcagacttga 1272961 tttctggtga cgtcaaacca ttttcaatgg tggagggact ggatgatacg tttagaggcg 1273021 ctttgtttct cggttatcat gcgagagcct cgactcctgg tgtcatgtca cacagcatga 1273081 ttttcggcgt ccgtcatttt tacataaacg atcggcctgt cggtgagctt ggattaaatg 1273141 catacgttgc cggttattat gatgtcccgg tattaatggt agccggggat gaccgggcgg 1273201 cgaaggaagc agaagagctt atcccgaacg tgacgacagc cgcagtcaaa caaaccattt 1273261 caagatccgc agtgaagtgc ttgtcgcctg cgaaagccgg acggctgttg acagaaaaaa 1273321 ccgcatttgc cctgcaaaac aaggacaaag tcaagccgct cacaccgcct gacaggccag 1273381 ttctgagcat tgaattcgcc aattatggcc aagcagaatg ggcgaatctg atgccgggaa 1273441 cggaaatcaa gacgggaact acaaccgttc aatttcaggc gaaggacatg cttgaagcct 1273501 atcaggcgat gcttgtcatg actgagcttg cgatgcggac atcattctgc taaaggggtg 1273561 ttttaggctt tggcgcgata catgataaag cgtttttggg caatggcagc tacgattttg 1273621 gtgattacca ccctgacttt tgttctcatg aaggtcattc ccggatctcc ttttaacgag 1273681 gagagaggca caaatgaagc cgttcaaaaa aatctcgaag cctactatca cttagacgat 1273741 cctctcattt tccaatacat tttctactta aaatccatca ttacattcga tttcggacct 1273801 tcaattaaaa aaccgtcgga cagcgtaaat gatatgctgg aacgcggatt tcccgtttcc 1273861 tttgagcttg ggatgacagc gattgtcatt gctgtgattt ctgggctggt gctgggcgta 1273921 atcgctgcac tccgccgcaa tggctttttg gactacgccg cgatgagtct tgcagtactc 1273981 ggcatctcca tcccgaattt tattctggca acattgctca ttcagcaatt tgctgtcaat 1274041 ctcaaactat ttcccgctgc gacatggacg agcccgattc atatggtgct tccgaccgca 1274101 gcgcttgctg tagggccaat ggcgatcatt gccaggctga cacggtcgag catggtcgaa 1274161 gttctgacac aggattatat ccgcacagca aaagcaaaag ggctttctcc gttcaaaatt 1274221 atcgtaaaac acgcactcag aaatgcactc atgcccgtca ttaccgtcct gggcacactc 1274281 gtcgccagca tcttaacagg aagctttgtc attgaaaaaa tctttgccat tccgggaatg 1274341 ggaaaatatt ttgttgaaag cattaatcag cgggactacc ccgtgattat gggaacgacc 1274401 gttttttaca gcgtcattct gattatcatg ctgtttttgg tcgatttggc ctacggtctc 1274461 ttagacccgc gcattaaact gcataagaaa gggtgaagcg tgtgaatctc cctgtacaaa 1274521 cggatgaacg ccagccagaa cagcacaatc aggtgcctga tgagtggttt gtcttgaatc 1274581 aggaaaaaaa tcgggaagcc gattcggtca agcggccgag tttgtcatac acgcaggatg 1274641 cctggaggag gctgaaaaaa aataaattag cgatggccgg actctttatt cttttatttc 1274701 tttttgtcat ggcagttatc gggccctttt tatcgcccca tagtgtcgta cgccaatcgc 1274761 tgacagaaca aaatcttccg ccctcagccg atcattggtt cggcaccgat gaactcggcc 1274821 gggatgtgtt tacccgaaca tggtatggcg cgagaatctc gttgtttgtc ggcgtgatgg 1274881 cagcactgat tgattttttg atcggtgtca tttacggagg cgttgccggc tataaaggcg 1274941 gcaggattga cagcattatg atgcggatta tcgaagtgct gtacggactg ccgtatctgc 1275001 ttgttgtcat tttgctgatg gtgctcatgg gaccgggact gggcacgatt attgtggcgc 1275061 tgactgtgac cgggtgggtc ggcatggcga gaattgtaag aggccaggtg cttcagatta 1275121 aaaattatga atatgtactc gcctcgaaaa cctttggcgc gaaaaccttt cgcatcatcc 1275181 ggaagaattt gctgccgaat actatgggag cgatcatcgt acaaatgaca ttaaccgtac 1275241 ctgccgccat attcgcagaa tcatttttaa gctttctcgg cctgggcata caggctccgt 1275301 ttgcaagttg gggcgtgatg gcgaatgacg gcctgcctac gattttatct gggcattggt 1275361 ggcgcctgtt ttttccggcc tttttcatat ctctgacgat gtacgcgttt aatgtgctgg 1275421 gggacggatt gcaggatgcg cttgacccta agctgaggag gtagctgtat ggaaaaagtt 1275481 ctgtcagtcc aaaatctgca cgtgtctttt acgacttacg gcgggacggt tcaggcggtc 1275541 agaggggtga gctttgattt gtataaagga gaaacctttg cgatcgtcgg cgaatccggc 1275601 tgcggcaaaa gcgttacctc ccaaagcatc atgggcctgc ttccgcctta ttcggcgaag 1275661 gtgacagacg gcaggattct atttaaaaac aaagaccttt gccgtctctc tgacaaagaa 1275721 atgagaggta taaggggagc cgacatttct atgatttttc aagacccgat gacggcgtta 1275781 aaccctacgc tgactgtcgg cgaccagctg ggggaagcgc tattgcgcca caaaaaaatg 1275841 agcaaaaaag cggcacggaa agaggtgctt tccatgctgt cattggttgg tattccagat 1275901 cccggagagc gcctaaagca atatccccac caattcagcg gcggtatgag acagcggatt 1275961 gtcattgcga tggcgctgat ttgcgagcct gatatcttaa ttgcggatga accgaccacc 1276021 gccctggatg taaccattca ggcacagatt ttagagctgt ttaaagagat tcagagaaaa 1276081 acggatgtgt ctgtcattct gattacgcac gatttagggg ttgttgccca ggtagctgac 1276141 agagtcgcag tcatgtatgc cgggaaaatg gcggaaatcg gcacaagaaa agatattttt 1276201 tatcagccgc agcacccata tacaaaaggc ctgctgggct ctgtcccgcg gctggattta 1276261 aatggcgctg agctgacccc gattgacgga acgccgccgg atttattttc gcctccgccg 1276321 ggctgcccgt ttgccgcccg ctgtccgaac aggatggttg tgtgtgacag ggtgtacccg 1276381 ggccagacga tcagatctga ctcgcacacc gtcaactgct ggctgcagga tcaacgagca 1276441 gagcatgcgg tgctgtcagg agatgcgaag gattgaacat gaaaaggggg aagaggatga 1276501 aacgagtgaa aaagctatgg ggcatgggtc ttgcattagg actttcgttt gcgctgatgg 1276561 ggtgcacagc aaatgaacag gccggaaaag aaggcagtca tgataaggca aaaaccagcg 1276621 gagaaaaggt gctgtatgta aataatgaaa atgaaccgac ttcattcgat ccgccgatcg 1276681 gctttaataa tgtgtcatgg cagccgttaa ataacatcat ggaggggctg acgcgtcttg 1276741 gcaaagatca tgagcccgag ccggcaatgg cggagaaatg gtctgtttcg aaagataata 1276801 aaacttacac atttacgatt cgggaaaatg cgaaatggac aaacggagat cctgtaacag 1276861 ccggagactt cgaatacgcg tggaagcgga tgcttgatcc gaaaaaaggc gcttcatcgg 1276921 cattcctagg ttattttatt gaaggcggcg aagcatataa cagcgggaaa gggaaaaaag 1276981 acgatgtgaa ggtgacggca aaggatgatc gaacccttga agttacactg gaagcaccgc 1277041 aaaaatattt cctgagcgtt gtgtccaatc ccgcgtattt cccggtaaat gaaaaggtcg 1277101 ataaagacaa tccaaagtgg tttgctgagt cggatacatt tgtcggaaac ggcccgttta 1277161 agctgacgga atggaagcat gatgacagca tcacaatgga gaaaagcgac acgtattggg 1277221 ataaggatac agtgaagctt gataaggtga aatgggcgat ggtcagtgac agaaatacag 1277281 attaccagat gtttcaatca ggggaacttg ataccgctta tgtccctgct gagctgagtg 1277341 atcagctgct tgatcaggat aacgtcaata ttgttgacca ggcgggtctc tatttctatc 1277401 gatttaatgt caacatggag ccgttccaaa atgaaaacat cagaaaagcc tttgcgatgg 1277461 ctgtggatca agaggaaatt gtaaagtacg tcacgaaaaa taatgaaaaa ccggcgcacg 1277521 cctttgtatc gcctgggttt acgcagcctg acggcaaaga tttccgtgaa gcaggcggag 1277581 acctgatcaa gcctaacgaa agcaaagcga agcagctgct cgaaaagggc atgaaggaag 1277641 aaaactataa taagcttcct gcgatcacgc ttacttacag cacaaagccg gagcataaaa 1277701 agattgccga agctattcag caaaaattga aaaatagcct tggagtcgat gtgaagctgg 1277761 ccaatatgga atggaacgta tttttagagg atcaaaaagc gctgaaattc caattctctc 1277821 aaagctcatt tttgcctgat tatgcagacc ctatcagttt tctggaagcc tttcaaacgg 1277881 gaaattcgat gaaccgcaca ggctgggcca ataaagaata cgatcagctg atcaaacagg 1277941 cgaaaaacga agccgatgaa aaaacacggt tctctcttat gcatcaagct gaagagctgc 1278001 tcatcaatga agcgccgatc attccggttt atttttataa tcaggttcac ctgcaaaatg 1278061 aacaagtaaa aggaattgtc cgtcaccctg tcggctatat cgatttaaaa tgggcagata 1278121 aaaactgatg gaggcgattg aggaaatact gcttctttat gcgaaggagc ggtatttttt 1278181 ctctttcttg cacgtatacg tagggtgcag agcaaatgaa aggagtgttt tcgttgaatt 1278241 acaagccgaa agcgttgaac aagggtgata cagtcggagt gatcgcgccc gcaagtccgc 1278301 cggatccaaa aaagcttgac accgcgcttt tatttttaga agagctcggt cttcaggtga 1278361 agttgggcaa ggcgctgaaa aaccagcacg gctatttagc gggacaggat gatgagcggc 1278421 tggcggatct ccatgagatg ttcagagacg atgaggtaaa agcagtgttg tgcgcatgcg 1278481 ggggttttgg gacaggacgt atcgccgcgg gcattgattt cagcttgatc cgcaaacacc 1278541 ctaaaatctt ttggggatac agcgatatta cgtttttaca tactgccatt catcaaaaca 1278601 caggtcttgt cactttccat ggcccgatgc tcagcacgga tattggcctt gacgacgttc 1278661 acccgctgac aaaagcgtca tataagcagc tcttccagga gacggaattc acctatacag 1278721 aagagctttc tccgctgacc gagcttgttc ctggaaaagc ggaaggcgag cttgtcgggg 1278781 gaaatctgtc tttgctgacg tctacactgg gcacgccatt tgaaattgat acgagaggaa 1278841 agcttctgtt tattgaagat attgacgagg agccttatca aatcgaccgg atgctgaatc 1278901 agctgaaaat gggggggaag ctgacggacg cggcgggaat tctagtttgt gattttcaca 1278961 attgtgtccc ggtgaagcga gagaagtctc tctcgcttga gcaggtgctg gaagactata 1279021 ttatttctgc gggcaggcct gctctgagag gatttaaaat cggccactgc tcgccaagta 1279081 ttgccgttcc gatcggtgcg aaagctgcta tgaatacagc agaaaaaaca gccgtaatag 1279141 aggcgggcgt ttcagaaggg gcgctgaaga catgaaaatc attcgaatcg aaacaagccg 1279201 aatcgctgtc ccgctgacaa agccgtttaa aaccgcactt cgcactgtgt atacggctga 1279261 atcagtcata gtaaggatta cttatgacag cggtgcagtc ggatggggag aagcaccccc 1279321 gacgttagtg attacaggag acagcatgga tagcattgaa agtgccatcc accatgtgtt 1279381 gaagccggca ttgcttggaa aaagcctggc gggctatgag gccattctgc acgacatcca 1279441 gcatcttctt acaggaaata tgagcgcgaa ggctgctgta gaaatggctc tatacgacgg 1279501 ctgggcgcag atgtgcgggc tgccgcttta tcaaatgctt ggcggatatc gagatacgct 1279561 ggaaacagat tatactgtca gtgtcaactc acctgaagag atggcagctg atgccgagaa 1279621 ttatctcaaa caaggctttc aaacgctgaa aataaaggtc ggaaaagatg atattgcaac 1279681 agatatcgcc cgtatccagg aaatcagaaa acgtgtcgga tcagctgtga aactgcgttt 1279741 agacgctaat caggggtgga ggccgaagga agcggtaact gccattcgga aaatggagga 1279801 tgcgggccta ggcattgagc ttgtcgagca gcctgtccat aaagatgatc tcgctgggct 1279861 taaaaaggtg acagatgcaa cagatacgcc gattatggct gatgaaagtg tttttacacc 1279921 gcgccaggcg ttcgaagttc tgcaaacccg gagcgcagac ttgatcaata ttaaattgat 1279981 gaaagcgggc ggcatcagcg gagcagagaa aattaatgcc atggcggagg cctgcggggt 1280041 ggagtgtatg gtcggcagca tgatcgaaac gaagctgggc attacggccg cggcgcattt 1280101 tgcggcaagc aagagaaaca tcacacgctt tgattttgac gcgccgctga tgctgaaaac 1280161 agatgtattc aatggcggca taacatatag cggcagcacg atttcgatgc ctggcaaacc 1280221 gggcctcgga atcatcgggg ctgcgctttt gaaaggggaa aaagagcaat gatgcacact 1280281 gtcatatcag cagtggccaa catctggaca gcgcctgatt cacctcgtcc gtctgatcaa 1280341 ttcatgcttc aaccgactgt aatgatcaga gactggctgg agcgcatgac gtatgatgaa 1280401 cggcttggat tatgtacaga caatgtaatc caaactcagg ttctctttgg cgaaaaggta 1280461 cttgtgacgg cggaacaggg ggaatgggtt tctgtgatcg tgcctagcca gccatcccga 1280521 aaggatccgc gcggataccc gggctggatg aaaaagtacc agctggaaaa aacaaagccc 1280581 atccatacac aacacgatgt gatgatcagc aaacctgctg cctttttgta cagaagcaat 1280641 ggggaaaagg agatcgaatt aagctttttg acagttctgc cccttattgc aaaagaaaac 1280701 ggatatttta aggtttcgac cgtttttggg gaaaggtttg tgaggcaaag tgatgcagtg 1280761 cctgtcagcc aacagaaagg gactgctgaa gacatcattc aaacgggtgc gttttttctt 1280821 ggccttccct acctgtgggg agggatcagc gggtttgggt ttgattgctc cggatttatg 1280881 tacagtatat ttaaggcgaa tggatacagc atcccccgtg atgcgggaga tcaggctaag 1280941 gcagggaagg gtgtcccgct tgatgatatg aaagccggtg atctgctgtt ttttgcttat 1281001 gaggaaggaa aaggagcgat tcatcacgtc ggtctgtatg taggcggcgg gaaaatgctt 1281061 cattctccaa agacagggaa gtcaatcgaa atcctcacat taacagagac aatctatgaa 1281121 aaagaattat gtgcggtgcg ccgctgtttt tcagaataag gagggagaca aatgaggcga 1281181 ctgcctttgt tagaggtcag ccagctgaaa atgcattttg acgcagggaa aaagcggaca 1281241 gtcaaagctg tcgacggggt cacctttcag attcgtgaag gagaaacgtt cgggctagtc 1281301 ggggaatcag ggtgcgggaa atcaaccttg gggagagtgc tgatgcgcct ttatcagccg 1281361 acagaaggaa gcgtgacata ccgcggcaca aatcttcatg cactaagtga aaaagagcag 1281421 tttgccttca accgcaaact gcagatgatt tttcaggacc cttatgcttc acttaacccg 1281481 cgcatgaccg ttcgagaaat tattttggag ccgatggaga ttcataatct ctacaatacc 1281541 cataaagcac ggcttctcgt cgtggacgag ctgcttgagg cagttgggct tcaccccgat 1281601 tttggcagcc gttatccgca tgaattcagc ggcgggcaaa ggcagagaat cgggattgcg 1281661 agagcactgt cgctgaatcc tgaatttatc gtggcggacg aaccgatttc tgcacttgat 1281721 gtctctgttc aagcgcaggt ggtcaacctg ctgaagcggc ttcaaaaaga gaaagggctt 1281781 acgtttttat tcattgccca tgatctttcg atggtgaagc atatcagtga caggatcggt 1281841 gttatgtact taggacacat gatggaaatt acagagagcg gcaccttgta tcgtgaaccg 1281901 ctccatccct atacaaaggc gcttttgtcc tcgattccga ttccagatcc tgaattggag 1281961 gacaagcgtg agcgtattct cttgaaaggg gagctgccga gcccggtcaa tccgccaagc 1282021 ggctgcgtgt ttcgtacccg ctgtccggag gcgatgcctg aatgtggaga atctcgtccc 1282081 cagcttcaag aaatcgaacc cggccgtttt gtcgcttgcc atttgtatcg aaatgctgaa 1282141 acgaaggaaa aagtaagata aataaaaaga gtggctcctt tttactagag ccactccatt 1282201 tgtttatact tgatgtaaaa actttacaca aaccgggtaa gggacagaaa ccgttgatgg 1282261 gaggagtgtc aatcggccgg tttctttgtc tctttcaaac aagacaaggt tgcctgtttc 1282321 ttcatttgaa gcaacgagga acccttccgt tgggtcaaat acaaagtcac gaggccagtt 1282381 tccttctgtc gacactcttt ctacgaaagc cagctctcct gaatattgat tcacttcaaa 1282441 tacggcgata ctgtcatggc cgcggtttgc gacataaaca aaacgtccgt cctgcgtgac 1282501 atgtattgcg cttccctggc tgttatctgt aaaatcatca gggatggcag aaacgacttg 1282561 gatttctcta aattcgccgg ctgtcgggtt gtattcaagc gcaatcactt cattgcttaa 1282621 ttctgtcatg acataagcgt atttttcttt cggatgaaaa gcgatatggc gaggtcctgc 1282681 accgggagcg aaggaatggc ttccggattc agtcaacaca ccgtctttaa gcttataggt 1282741 gtagagctta tctataccta aatcaaccgc taccacataa ttgtgttcag gtgtgaaccc 1282801 cgcgtagtgt gtatgcggtt tttcttgtct ttcgtgcggc ccttttcctg tgtgagcggc 1282861 ctctgaaaca ggtgattgca agctgccgtc ttcctgaacc ggaaaaacgt gtaccttccc 1282921 gctgtgataa ttggcagtca gtacgaattg attttgatca tcaacgctta cgtggcatgg 1282981 cgaagggcca tcaattaact gatgattcag aaatgtcaat tcgccgctgt ttttatcgat 1283041 ttgataggca gcaactccgc cttggccgtc tgctttttcg atggaataaa ggatggtgtt 1283101 gtttttattc gtcgccacat atgtcgggtt gcccagctta gcggccagct ttggctcgct 1283161 gagtgctttt ttctcagtat caagctcaaa tgaataaatt ccttcgcttc cgccttttgt 1283221 atatgttccc acatatccta tgtattttgt catgcgattt cccccttaaa aatgatgtca 1283281 cctctatatt aacgtatctt gataaaataa gctgttcaaa acatgaaaaa ggggaagatt 1283341 cttcattcgc ctcgaatcag cggcattgtg cagcacctga aggagccgcc tgatttaata 1283401 atttctgaca ggtcaatttc gataatgtga tagcctcttt tcgatagctg ttgattgaca 1283461 tggcggttgc cagggagact gatgatcgtt ttttttccga ttgaaaggac gttggtgcca 1283521 agcgtaaatt gttcgtcctc gggcacctca ataagatcat aacgttttgc cagcatatcg 1283581 gctgcatctg gctcaatggc ctgtgaataa attaacgctt cgctttcaga tataatgtta 1283641 aatacgcagt ccaaatgcaa aaatttttca tgaagcttca ctggaacgat cgtatattca 1283701 ggaagtgcct cttctagctg gccgatagct gaaatgtcgg tgcgctggct gattccgaca 1283761 tagacaatgt catcatcgat aatgacgtct ccgccttcaa tactcgtatc aagcatgcgg 1283821 gtgtaagaga taccttggct gtgaaaaaaa tcttttataa cggcttcttc tccttggcga 1283881 atcggttcag tcatgcttga cagaaaggct ttttctccga tgacaaatcc tatgtcccta 1283941 gtaaaaacct gttctgggag tccgtcgcga acgggcaaaa ggacgacctc aacgttgtgt 1284001 gacctaagtg cctccactaa gcggctgtgc tggtcgttag cggtttttac atgaatattg 1284061 tcatcttcaa aatgtttttg tgtttcgttt ataacatctt ttatggtcat gtgctcaggt 1284121 ttgcataaga tcactttttg aagtgtgccg tattccgttc ggcataccgt tttgtgctga 1284181 gatttcggga tggatacgtc catttgtttt tcctcctaaa gtgtgaagaa tacatttatt 1284241 attccctcat catgaaaatc attaaaccat tttaaatttt agacaaatgg aagagaatat 1284301 tgtttaatag gagaatataa gtgcatttag ctaaaagatc agacatcaaa ggggagaaag 1284361 gtatggaaac accggaaaca agattttgta aagagtcaaa ggttgtgaaa accagcaggg 1284421 tgttcccgct tgacacgaac aaccataata cgctgtttgg cggaaaatta atgagctaca 1284481 tagacgacat tgcctctatt tcagcggcgc gccattgcag acgtgaaacg gtaacagctt 1284541 caatggattc tgtagatttt ttaaagccga tcgggcaaaa ggattctgtc tgcctagagt 1284601 catatgtgac atgggtcggc acatcttcca tggaagtatt tgtgaaagtt attaaggagc 1284661 atttgatgac tggcgaacgg gaactcgctg ccacatcctt tttgacattt gtcgcattag 1284721 attcaaatgg caagccggtg cctgtaccga gggttgtacc ggaaacagaa gaagaaatca 1284781 tgctgcataa tacagctgta cagcgtgcta atgaacgtaa gaaccgcaag agacacagcc 1284841 aggcgcttgc aaatgcgctc ggaactgata agccttggtg aacgttaaac ccaaaacata 1284901 agttgttttg ggtttttttg tacttttcaa tggtgattat tacaatggtt agtccgtttt 1284961 tgctagggga ttctataaaa aagcaacaaa tgtcatgtta aattgataat tttgtgacaa 1285021 ctttattaaa gattcatttt agatatatct tttattcgta agatcatgta ttttaaagat 1285081 atattttaaa tacatctttt cgaaaggatt gtttataaaa tgttagataa caaaacaatc 1285141 gaaattatta aaagcactgt acccgtattg caacagcatg gagaaacaat cactggccgt 1285201 ttttacgatc ggatgtttca agaccatcca gagcttttga acatttttaa tcaaacaaac 1285261 caaaagaaaa aaacacagcg aactgcactg gcaaatgccg ttattgcagc tgcggcaaac 1285321 attgaccaat taggaaacat cattccggtt gtcaaacaaa tcggccacaa gcaccgcagt 1285381 atcggaatta agcctgagca ctacccaatc gtcggtaaat atttgctgat tgcgattaaa 1285441 gatgtattgg gagacgctgc aactcctgac attatgcagg catgggaaaa agcgtacgga 1285501 gtcattgctg acgcgttcat cggaattgaa aaagacatgt atgaacaggc tgaagagcaa 1285561 gccggcggct ggaaggagta taagccattc gttatcgcaa aaaaagagcg ggaaagcaaa 1285621 gaaattacat ccttctattt gaaaccggaa gacagcaagc cgttacctga attccaagca 1285681 gggcaatata tcagcatcaa agtgcggatt cctgattctg aatatacgca tatccgccag 1285741 tacagcctgt ctgatatgcc gggaaaagac tattatcgaa tttcagtgaa gaaagatggt 1285801 gtcgtgtctt cctacttaca cgatgggctg caggagggag attcaataga gatcagcgca 1285861 ccggcagggg actttgtttt agatcatgca tcacaaaaag atctcgtttt gatcagtgcc 1285921 ggagttggca ttacaccaat gatcagcatg ctgaaaacat ctgtttccaa acagcctgaa 1285981 cggcaaattc tgttcattca tgcggcgaaa aacagtgaat atcatgcatt gcgccatgaa 1286041 gtagaagaag cagcaaaaca ttctgctgtt aaaacagcat ttgtgtatcg cgagccgaca 1286101 gaggaagacc gtgcaggtga tctgcatttt catgaaggac agattgatca gcaattcctc 1286161 aaagaactga ttgccaacac agatgcggat tactatattt gcggttcacc gtcgtttatt 1286221 acggcaatgc ataagcttgt atcagagctc ggatcagcgc cggagtctat ccattacgag 1286281 ctattcggcc cgcaattaag tttggcgcag tccgtttgaa cacatacatg aaactcttct 1286341 cctttcagag aagagttttt tattgagata taagaaggca gacaagcgcc ggtttctaca 1286401 tccggacaat cacagacccg ctgccatttg tgcatacacg gttttgctgt tcttgcattg 1286461 ttctcagcaa ttcattgttt acctcaatcg ctctaattag ttgcttcatt cttagctcca 1286521 aaccggccag cctgtcgatt gtttgctgct ggtagccctc gggttgggga gccaatggca 1286581 gatcaaaggg ccaaagggta ttcgacttct gatttttcat attgcgtatt gcgcctccaa 1286641 tcggtgtcac tttctattat gttatgttca ggcgatatgc acgttcgcct agacactgat 1286701 gcatagaggg cctgccacgg ggcacaatag gctcaatatg accagcggat ggaggtaaag 1286761 atcggtgtta tggatggtat gggtattttt actgaagcca gttatcgtat tttcgattgc 1286821 atatattttg tttcggcttg ccggtaaaaa agctgtgtca caaatgaaca attttgacct 1286881 gcttttgacc ttcgcaatcg gaaccattat cagtgagccg atccttacat ccaagctgcc 1286941 gatgtcaatt tattatgcgg gtgctttttt ggtgctttat cttatcatga gcaagctctc 1287001 tttatctaat aaatggcgat ggctcctagt cgtgagcccg actgtcctaa tccgaaacgg 1287061 ggatattgat gaacgcggcc ttcgtaaaga aaggctgact gttaatgagc tgctcggaaa 1287121 gctgagggaa aagggctatg ccgacccggc tgacattgat cttgctatca ttgaagaaac 1287181 gggagaagta agcgtcatcc cgaaagagga agcgagagcg gtgcaggtgc gggatttgaa 1287241 tatggaagct gaacggaatt ttatcccgat tccgctcata ctggatggcg aaatccttga 1287301 tcataatttg aaatatctcc aaaaaaaccg atcctggctg tttgagaagc ttgaggaaaa 1287361 agggtacagc cccaaactgc tgtcttcgat tatccttggc acgatgaatg cacgcggtga 1287421 tatatccctt gatttaaata ccgctaatga accgcagcat gatccttact tatataaacc 1287481 gggaaataac aattaagatg gctctctctt gtaatgagag cttttttctt ttttaaaggg 1287541 aatttttgtt tggtgtcaaa tgtacctagt taggagggga actgaacatg aaggacttat 1287601 ccataagaaa cgacatggcg ccaacggtca gtttgctgta ttccgcagtg gaagaaaaca 1287661 gtctccgtct ggcttccatc gtaagccata tgacacacag tgaactttac tataaggggc 1287721 gctgccaaac aaaaaacagc acggctcagc ttttgcacca tatcacaaat gttgatatca 1287781 gatgggtctg gcgtatcaag gaaaatcgga tcccggacca tattgaacag gcatacggcc 1287841 cgatgacaga tgaaagcgga cggctgcctg aaccggtgaa tcagccagac ttagatgaac 1287901 tcctgaaaag acatcagcat gtagtagaga agctgaaatc ggtatgcttc actttaactg 1287961 aaaatgcttt gaaccagccg ctttccttcg aaggtgacac cgcgacgata cgatggggaa 1288021 tttggcatat ggcagatcat aaccgctatc atcaggcaca tattgaagct ctcaaaaaag 1288081 aatggaagca ggatgtggcg aagtatgaac gctaaaacga agcttgtgac tgatcgaatt 1288141 cgtttgcgct gtatggaaga tcgggatcaa gccactttgt ttgggctgct ttttaatgat 1288201 cctgacgtca tgacatatta ttccggttta aaagataaga ggcaaacccg cgagtgggtc 1288261 aattggaacc aacgaaatga aaaagggtac ggcgttagtc tgtggatcgc cgaagataag 1288321 cggacagggg agtttttggg gcaatgcggc atcgttcccc agcagatcga aaatcaaacc 1288381 gtaatggaaa ttggctatat gtttgcccgc cgccactggg ggaacggcta tgcgcaagaa 1288441 gcggctcggg cctgtctgga ctatggcttt aacgagcggc agttcggcaa aatggcggct 1288501 ttgattgatc cgggtaacaa agcgtccata cgggtagcgg agaaaatcgg catgcattac 1288561 agcaaaacga tcagaaaatg gaataaaccg atcgcggtat atgaaagaaa atcttacaat 1288621 tgaaagatag agctgagttt agtatcatga tatcatgtaa agttttctag ggttccgcat 1288681 gtcaattgac atggactggt ccgagagaaa acacatacgc gtaaatagaa gcgcgtatgc 1288741 acacggaggg aaaaaagccc gggagagtca atctcatgtg agacgactgt ccggggtttt 1288801 tttgttttcg gagaatctta atagatagaa aggaatgact caaaatgaaa tggggattgg 1288861 tcgtgcttgc cgctgttttc gaggttgttt gggtgatagg cttaaagcac gctgactcag 1288921 ccttaacatg gagcggcact gccatcggca tcatattcag cttttacctt ctaatgaagg 1288981 cgactcacag tctgcctgtt ggtaccgtgt atgccgtctt taccgggctc ggcacagcgg 1289041 gaacagtact tagtgaaatc gttctttttc atgaaccggt tggatggccg aagctattgt 1289101 taattggcgt gctcttaatc ggtgtaatcg ggttgaagct tgtgacacag gatgagacag 1289161 aggaaaaagg aggcgaggca taatgctgca ctggatcagt ttattgtgcg cgggctgttt 1289221 agaaatggcc ggcgtggccc ttatgaatca atatgcgaaa gaaaaaagcg tgaaatgggt 1289281 gctgttgatc attgttggtt ttgccgcttc attttccttg ctgtcgtacg caatggaaac 1289341 cactccgatg ggaacggctt acgcggtctg gacaggaatt ggcaccgccg gcggggcgct 1289401 tatcggcatc ctcttttaca aggagcagaa agacgccaaa cggatcttct ttatcgcgtt 1289461 gattttatgc tcagcagttg gtttaaaaat tctgtcataa attgattttt atcaaatctt 1289521 cagtataatg gataaatagt ttagacttac aaagataaga gggattattc atgaaatcat 1289581 atatgactca gcggttggac gaataccgtg acggaaatga ggataaaggt cggctcttgg 1289641 tcagctgccc cgatcagccg ggtatcgtct ctgcagtttc cgcgttttta tttgaacacg 1289701 gtgccaatat tatagaatca aatcaatata cgacagaccc tgaaggcggc cggttcttcc 1289761 tgagaatcga attcgactgc gcaggcattc gtgaaaaaaa atcatcactt caggcagcgt 1289821 ttgcctctgt tgcggaaaaa ttcgacatga catggagctt aactttggcg agcgaactga 1289881 agcgtgtcgc cattttcgtt tcaaaggagc tccactgcct gcatgagctg atttgggaat 1289941 ggcaaaccgg caacctgatg gcggagatcg ctgttgtcat cagtaaccat gaggaagcga 1290001 gagagctggt tgagcgcctg aacattccat tccactatat gaaagcgaac aaagacatca 1290061 gagcggaagt cgaaaagaag cagcttgaac tgctggagca gtacgatgtt gatgtgatcg 1290121 tgctcgcacg ctatatgcag attctaactc ctgattttgt ttcggctcat ccgaatcgca 1290181 tcatcaatat ccaccattca ttcctgccag cttttatcgg tgcgaatccg tacaaacggg 1290241 cctacgagcg cggcgtgaaa ctgatcggtg cgacatctca ttatgtgaca aacgatcttg 1290301 atgaagggcc gatcattgaa caggatattg agcgtgtgga ccaccgcgat aatgcggaag 1290361 cgctgaaaaa catcggaaga acaattgagc gcagcgtgct tgcccgtgct gtgaaatggc 1290421 atttggaaga ccgtgtcatc gttcatgaaa ataaaacaat cgtctttaac tagactgcaa 1290481 gaggcccgcg caatgcgggc tatttttgat gacaaaaaac cttgacaagt gtcttttttc 1290541 tttgcataat ataaaaaaat cattgagcgt tgaagaggat tagtaagcag acctttctgt 1290601 gacagagagc aaaatgaatc gctgaaacat tttgccgcat gaaacctgcc gaacctgcct 1290661 tggagtccta gggggaaaac ctaggcgcat aacctggcgt tacaggagag cggagcgtgc 1290721 acaagcgcgt tcaatcaagg tggtaccacg gaaacccatt tcgtccttat gaatcaggat 1290781 gaaatgggtt tttttattgt agaagagccg cggaggagaa taaatgaaaa aacaaagaat 1290841 agtagtgaaa ataggaagca gttcgctcac gaatagcaaa ggaagcattg atgaggcaaa 1290901 aatcagagag catgttcagg cgatttccgt gttaaaaaaa gcggggcatg aaatgattct 1290961 gattacctcg ggtgccgtag cggcggggtt ttccagcctc ggttatccat cccgtcccgt 1291021 taccatcaaa ggaaaacagg cggcggccgc ggtcggacaa acactgttaa tgcagcaata 1291081 tatgaatcaa tttaaacaat actcactgac tccgggacaa atccttttaa cgagaaatga 1291141 tttttcgaaa agagaacggt atcgaaacgc gtatgctacg ataatggaat tattagagcg 1291201 gggcgtcatt ccgattatca acgagaacga ttctacatct gttgaagaat tgacattcgg 1291261 agataatgat atgctttctg cgttagtcag cggattgatt cacgcggacc agctcatgat 1291321 tctcactgac attaacggac tgtatgatgc caatccaaat gaaaatcctg aggcgaaacg 1291381 atttgattat ttgccagaga tcacgcctga attgcttgga tatgcaggtt cagctggatc 1291441 aaaggtcggc accggcggaa tgaaatcaaa gctgttagcc acacaaaccg cgctgtctct 1291501 gggagtgaaa gtattcattg gaactggcag cggagagcaa aaacttgcgg acattttgga 1291561 cggcagggga gacggcactt atatcggaga caaagaacta tcttcggtta acaacacaag 1291621 gcagtggatt cagttccact cgccgatatc gggagaaatt atcattgatg cgggtgccga 1291681 agaggcgatg atccataatg gaagcagcct tttgcccgct ggagttgtgg gcgtgaacgg 1291741 aagctttccg aaaggggcgg ttgtggaagt caggggaccg ggcggcgtga tcggcaaagg 1291801 ccaaactcat tactcctccg aggagattat ggaggctaaa ggcaaacgca gtgacgaact 1291861 tgattttgag aaaacgtttg aggttattca taggaatgac tgggtcaatg taaaagacta 1291921 ggaggcggaa aaatgagtga agtttctgta aaagcgaagc tggcgaaaga agcagcagcc 1291981 gaaatgatca tgaaaacaac agccgagaag gatgaggcgc tcagcctcat tgcaaacgga 1292041 ctccgcaaag aactggattt tctcttggcg gagaatgcaa aagacattgt gaacggaaaa 1292101 gagaatggtt taacaccgga catcattgac cgtctctcat tggatgagaa acggatacgc 1292161 gatatcgcgg acgcggtgga gctcttaatc gacttagcgg acccaatcgg cgactctctt 1292221 gaaacgattg aaaaagaaaa cggcctgttt attgaaaaaa tccgtgtgcc gctcggtgtc 1292281 gtaggaatga tttatgaggc gaggccaaac gtcacagttg atgcggctac cctttgcctg 1292341 aagacaggga acgcggttgt gctgcgggga agctcctcag ccatccacag caacaaagcg 1292401 ctcgtcagtg tcatttacag agcacttgag caatcagcgc ttccgattca cgctgtgcag 1292461 ctgattgagg atacgagcag agagacagca aaagagctct ttacgttaaa tgatggctta 1292521 gacgtattga ttccgcgcgg aggcaagaaa ctgattgatc tcgttgtgag agaatcaaca 1292581 gttcctgtat tagaaacggg agcaggaaac tgccacatat tcattgacga aacagccaaa 1292641 ccgcaaatgg cagaaaaggt tgttgtaaat gccaaaacgc agcgcccttc tgtatgcaac 1292701 gcgattgaat cattgctgat tcacaaggct tgggcaagac agcacggaaa agaattgctg 1292761 gaccagctgg aaaacgcggg agttgaaatt cgcggtgatg aattggtatg tgaacttcat 1292821 ccttcaagca aacaagcatc aaaagaagat tgggaaaccg aatttttagc gcctgtcctc 1292881 agcgtaaaga cggttgaaaa cgtccaagaa gctgtaaagc atatccaaca atacggcacc 1292941 aatcattctg aagcgatttt aactgaaaat gacaaaaatg cggtatattt tcaaacggct 1293001 gtcgatgctg ccgctgtcta tcataacgcg tcaacccgct ttaccgacgg ctttgaattc 1293061 ggctacggag ccgaaatcgg catcagcacg caaaagcttc atgcaagagg accgatgggg 1293121 cttcctgcac tgacttctac aaaatacatc attaaaggaa ctgggcaaat ccgtgaatag 1293181 cggggtaatg ttcaatgaaa aagcttatct cattacgaga taagcttttt tatacgcgaa 1293241 aaattgacat ttcaaattta attgtgtaca atttaattgt ataaaatata ttgggggaat 1293301 gaaaaatgag tcagccatta tttaccgcaa ctgtttcagc ggtaggagga agagaaggaa 1293361 aggtcatttc atcagaccgc gttcttgagc ttgatgtcgc aatgccgggg acaccgagag 1293421 ccaagaaatt agaaaaagcg acaaatccag agcagctgtt tgcagcaggt tatgcagctt 1293481 gctttgacag cgccctgcag cttgtcgcaa gaacagaacg ggtaaaagta gagacagagg 1293541 ttacagcaaa tgttagcctg ttaaaggatg aagcggacca gggctataag ctgggtgtga 1293601 cgctgcaagt aaaaggagaa ggagtcagtg catcagaatt ggaggcgctt gtgaaaaaag 1293661 cgcacggcgt ctgcccgtac tcaaaagcaa cctccggaaa tattgatgtg acacttgaag 1293721 ttgctgaata aataaaaaga ggatgcctgt acaaggcatc ctcaattttt ttgatgaagt 1293781 gtttccagta atgtatatag agcggacttt aactgtttga gatcctcccc agactgcttt 1293841 gagagcccca gaattgtccc tggaatgtca accgcttttt cttttaataa cgctccgtcc 1293901 tctgtcaggc tgatcaacac ggaccgctca tcctcttcag atctttttct cgtaatcaaa 1293961 ccctgttgtt ccattcgttt aagcatcgga gtgagcgttc ctgaatctaa atacagctgt 1294021 tcgcccattt ttttgacagt aagcgtttca tgttcccata acaaaagcaa agccaaatat 1294081 tgagggtatg ttatattcag cttatcaagc agcggcttgt attgctttgt catctcccgc 1294141 gaactcgcat atagcaaaaa acaaagctga ttctccaatt tcatatgatc aaatttattt 1294201 tccattttgt tcaccaactc ttttttgtca ttcgattcta ttgtatctga aaaacctcac 1294261 ttttcctatt ctcggcaaac atagcatgtt taaaaagatc agaaagggaa atataacaac 1294321 tagatacaaa taaggaggtt gggaaatatg gcactattta cagcaaaagt aaccgcgcga 1294381 ggcggacgag caggacatat tacatcagat gacggtgttc ttgattttga tattgtcatg 1294441 ccaaatgcca aaaaagaagg acaaaccggc acaaatccgg aacagctctt tgcggcaggg 1294501 tatgctgcat gcttcggcgg cgcgctcgaa cacgtagcca aagagcagaa tatcgaaatt 1294561 gattcggaga ttgaagggca ggtcagcctc atgaaggatg agagcgacgg cgggtttaaa 1294621 atcggtgtca cacttgttgt gaacacgaaa gatttagatc gggaaaaggc acaagagctt 1294681 gtcaacgccg ctcatgaatt ctgtccttac tcaaaggcaa ccagaggaaa tgttgatgta 1294741 aaactagaat taaaataatg accggcatcc tgaggattct caggatgttt tttggtgtcg 1294801 gacatgcggg gcgggcacag atttatgata aaacttcaga gaagcgtttg aagcatgcct 1294861 ttaaaccaaa agttacagat gaagcgggtg gctggcacgg tgtctgccgt gctgaattgc 1294921 gcgtatatgc tgttttgtat ttgcacaggg catagcggct acttggagaa ataacaagga 1294981 ccaggccgcg catgcctgat ccttttaata ttctttctta ttggcgaagt tccgccatgc 1295041 ttgaaacggg gataaatgct ctgttagtgt cacttgataa aaggggatcg ttctttcttc 1295101 agcaggttta tcaatttctt tataaatgaa tgaatcatca aacccggctt cggcagcgtc 1295161 tgtgtgctca gctgcataga aaacggcttt aggccgggcc cagtagatgg cgcccaagca 1295221 cattgggcat ggttcacagc tcgtatacaa aatgcagtca tcaagctggt aggctcctag 1295281 caccttacag gctttccgaa tagctgtgac ttccgcgtgg gcagtcggat cattgcttgt 1295341 tgtgacgttg ttctgtccct ctgcaataat ggctccgtct ttcacgataa cggctccaaa 1295401 aggcccgccg attcctgcat tcactccttc acatgcgaga gtgacagccc gttttaagaa 1295461 cgtttcatga ttcatcccaa tccctcctgt caatagagtg ttattagtat agccgaaaag 1295521 aatgcaaaga acattcttaa aaaagtgcaa aataaacaaa gtatttgggg gatttgctaa 1295581 ataagaaacc gattgtggct gtattataga aaaaaaccat ctgccaaatg cagatggttt 1295641 tttcaaatta tactagctgt gtctgctgtg ctcttgcctg ttttgcggct tcaaccatat 1295701 ttttcaatgc tgcaaccgtt tcttcctgct gtcttgtttt caatccgcag tctggattta 1295761 cccagaagcg gtcagtcgga cagacggcaa gcgcatcaac gataatattg tacatttctt 1295821 cagttgacgg cacacgaggg ctgtgaatgt catatacacc aaggccaagc cctttcaaat 1295881 acgggtggtt ttttaagtaa tctaaaaatc ctccgtggct tctgctatgt tcgattgtaa 1295941 tcacatcggc atcaagatca ttgattgtat caacgatatc ttcgaagttg ctgtagcaca 1296001 tatgtgtatg aatttgtgtc tcgtttttca cggaagaagt ggttaatctg aaagcttctg 1296061 ccgcccaagt caaatactca tcccaatcgc gggttttcaa tggaaggcct tcacgcagcg 1296121 ctggttcatc gacttgaatg atttgaatgc ctgcgtcttc aagcgcttta acttctttgc 1296181 gaagggcaag cccgatttgg aaggcgattt ctttcctcga gatgtcgttt cgagggaaag 1296241 accagtttaa gattgtaacc gggcccgtca gcattccttt cacatgcttg gaagtcaatg 1296301 actgtgcgta gactgtgtct ttcactgtca tcggttcaat aaattcaaca tctccgtaaa 1296361 tgactggcgg gcggacacag cgtgagccgt atgattgaac ccaggcatat ttagtgaagg 1296421 cgaaaccggc cagcttttca ccgaagtatt cgaccatgtc tgtccgttca aattcgccgt 1296481 gaacaaggac atcaagctcc aattcttcct gaatatcaat ccatcttttt gtttccgcat 1296541 tgataaagtt ttgatactgt tcatcggacc actcagcttt ccgccatttt tggcgtgcgc 1296601 tccgcacttc agcagactgc gggaagctgc cgatcgttgt cgtcggcaaa agcggaaggc 1296661 cgagagattc attttgtagg gctaaacgtt cttcaaacgg aatcgggcgc ttgaagtctt 1296721 tatcagttaa ttgctcaagc tctttctttt gttcagaatt ggcgcctgtt gcaaactgtt 1296781 taagcgcctg gatatcagcc ttagcctgct gaatctcttc gctgatcgcc gcttttcctg 1296841 atactaagcc ttctttcaaa gctgtcagct cggccagctt ttcttttgcg taggataatc 1296901 cgttcaatag gtctttttcc aaatgctcat cagggtgttt cgctactgga acatgcagca 1296961 ggctgctgga aggctgaatc cacagttcat caacttttgc aatgctgaga atatcaagaa 1297021 cggcatcgag acgctcttca aggtccgctt tccaaatgtt gcgtccgtcg ataacgccgg 1297081 ctgccagcac tttatctgtc gggaagccat gtgttttaag ctgttccagg tttctgcctt 1297141 tgtcgtgaac gaaatcaagg ccaattccct gaaccgggta agagatcagc tcttcataag 1297201 catcaacaga atcaaaatac gtctgcaaaa gcacattcaa ggatgaaagc tcacttgtaa 1297261 tgctttcaaa taattctttt gcgccgcgta catcttcact agaggcggta acgagcgccg 1297321 gctcatcgat ttgaacccat tttacgcctt cttcttcaag ctctttcaaa agctgtacat 1297381 ataatggcac aaggcgtttt tggatcgctt ttgcttcaga cggttcatag cctttagcaa 1297441 gcgtaacgaa cgtataaggg ccgacaatca caggctttgt ttccacaccg tattcctgtt 1297501 tgatccggcg ataatcttcg agttgtttgt ttcttgtcag acggaactca atgctctcgt 1297561 catattccgg aacgatgtaa tggtaatttg tattaaacca ttttgtcatt tcactagata 1297621 cagcgtcttt gattccgcgg gcgatagcga agtatgtatc ggtagcgtca gtcaaatgtc 1297681 tgaaccgttt cgggatccag ttgaagctga ctgctgtgtc gagtacatgg tcatactgtg 1297741 tgaaatcaga aacaggcaca acatcaatct gctggtcaat ttgtgttttt actgcggata 1297801 aaaatagttc gtcgatttgc ttcaaaaacg tatctttatc agtactgcct ttccaatacg 1297861 cttcaagtgc ttttttccat tcccggttca gtccgattct cggaaatcct aaattcgatg 1297921 ttttgatggt tgtcattgtt tctcctcctt tatatgtaaa acactctctt tcacccgcgg 1297981 atacaggctg ctaagaggtt ttctcacaac aaaaagcctc tttcccatga gagaaagagg 1298041 cttttctacg taaaacactg cctctctcat ctctcagaca caatctgatg gaattagcac 1298101 cgtgccttat gagacatcag tctcggcgcg aaaagcagtg cgccccattt cacaatggta 1298161 ttacggtcgg ttgctgttgg ggtcaaaagg ccaatccctc gcccaactct cgataagaga 1298221 aaatgttatt aattttttga aaagttgaat catttgttgg taatcttaac agtaattcaa 1298281 attcattgtc aacatagaat ttgaaatttt tatttacatg atgtggtgta tattatataa 1298341 gaaaaataat cttatagggt caacaaatgt gattgctctg ctttttctgc gagctcatca 1298401 ggagctgtta aatacaggaa tccattgcct gccagcgttt ttgcaatatc aagaggaagt 1298461 gtcctgcgga ttagctgtgc gaaaacctca gattcagaaa gctttctttg aaatgattct 1298521 tcttcatagc ttttgattaa agcaagcgca ccgctgacat gaggggcagc cattgaagtg 1298581 ccggtcagct taccgtactt cttgttggga agggtggata agatgttttc tcctggtgcc 1298641 acaaggtcaa tctctttatt cgcgttagaa aattctgata attctcgcgc tacagaaaca 1298701 gatccaactg caatcacttc attataagct gcggggtagg aaagctcttc tgtgcgttcg 1298761 tcgccgtcac cttcatttcc cgctgcacaa acgacaagca ctccgttttt cactgcgttt 1298821 ttcactgctt cttttagctc tggcacatcg cttggccctc caagggacat tgagatgatg 1298881 tcgactttct gttccaccgc gtagttgatg ccgttaatta tccattcgta ttgtccgctg 1298941 ccgttctcgc cgccaagaac cttcacaatc aataggcttg cctcaggcgc gactccggca 1299001 atgcctccgt ttgaatcatt agctgcaatt gttccggcga cgtgtgtgcc gtgtccgttg 1299061 tagtcggaaa tcgcatcttc cttgccgccg tcgtcatccg tgaagttctt tccgccgatg 1299121 atttgatttt ttaaatcagg gtggcttgtg tcgcagcctg tgtctaatac agcaacttta 1299181 atatttttgc cttttacccc ttttgcccac atttctggcg ccttaatcac tttaatgccc 1299241 tcaggaagct cgtttacatc catgatctgc tcattcgtca catacgggat caagcggatt 1299301 tcaccattca taaaaaagcc ctcctttttt atgcttgcaa gtggattcaa gggtgttgcc 1299361 tcatattata tgaaaaaagc aagcgctcgg acagagccat ttgaagcatt ttgaaaaaat 1299421 aggatacaca ccaaagaatt agtaatcttc aaaatattgg atggcttcaa catgtatgac 1299481 tgggattcaa ctgtaagtca agttataata gtgttgggga aaggagcagt gtcatgaaac 1299541 tgaatgaaaa attatatgca tttttttcag agcatgtgga acaaatggcc gaggaatgga 1299601 ttgaaacgat ggaggaaagt gatccgaatt cgctttacgc cctacataat gcaacagtaa 1299661 cggaagaatt gaaagagcag gacagagaat tttaccggca tctgaattac atgtatgttt 1299721 taccggaaaa acaatttctc gaagagtttc aagagtgggt cattgagctg accaacgatc 1299781 aaaaacatct cgacacaccg gttcagtatg tcattcggga gtttatgaga aacaggagat 1299841 tatatacgaa gtattttgag aagttcgcag aagaaaatga atcagcgttt gaaccgggag 1299901 agaagcaaaa atgggcagat ttgattgtaa aagtatttga tttcaccatt tatacattcg 1299961 ttgatcacgc tgaaatgaat gccaagcagc aattaaacgc ccaaagagaa atgatattgg 1300021 aattaagctc acctgtcatt accctgagca aatcaacagc tctgctgccg cttgtcggtg 1300081 acattgatac cgaacgggcg aagtttattc tggaaaacac gcttcaagct tgtgcgaaaa 1300141 gacgtgtgga gcatctgtta atcgatctgt caggtgttgt tgtggtggat acgatggtgg 1300201 cgcaccagat ctttaaattg attgaggcgc ttaatctgat cggtgtccgg tcaaccctgt 1300261 caggaatcag gcctgaaatt gcgcaaactg ctgtacagct ggggattgac ttttcgaata 1300321 ttactattaa aaccaacctt gcccaagcat taaactatca tcaataaaaa aatccgctat 1300381 ctgtgatagc ggatttttta tgatgcgaaa cataaagata cgagaaagga tcccgcgaat 1300441 aataagagga cgaggcaaaa gaacacccag tcgcgccggt tcacgctcaa tgtcctgtag 1300501 tatgtccggt ttctgcttcc tgtaaatcct ttcgattcca tcgcaagcgc tgtccgttcc 1300561 gcttttctga tggcgcttgc caatagcggt atggtatatc gttttaacgc actgatttta 1300621 ttaatgatgc cgctctccgc cgctcctcct ctgattttat gagcctgctg aatcagctgg 1300681 acctcatcct ttaacagcgg aagaaagcga aagcctgcaa tgacaccgta cgcgagcttt 1300741 ggtgagagcc tgcactgctg gacaaggctc agcataaata gaatcggatc ggttgtaaaa 1300801 acaaacatca tcgataaggc ggaaaagcat aaaatacgaa acccgagaga gatgccgaca 1300861 gacacattat cgctgttaat ggagataggg cctgcttgaa acaaaaaatt atccggtgtt 1300921 gtcggcactt ttccaaaaac tgcggctgtc cacacgcatc cgaatgctaa aatcaaaaac 1300981 ggaatcgtaa acaacaacca ttttttcaat gggattccgg ccgccagtaa aacgcccgca 1301041 acgatgatga tataaaaaca tgccggagtg taagggttgt aaataaacga cagcatgacg 1301101 acacaacaaa aaaccgccgc cgctttcaca gtcggattaa tgagatgtaa cggttgcttc 1301161 atcacgcacc tcctcttgaa atgccatcca ttcatataga aggggaaggg tgagctttgc 1301221 tttttgaaca agccctgttt cttgagaaaa caactgcgct ggagatccgt caaaggccag 1301281 gcctgtatcg tgaagcacaa gcacgctgtc agcatacgaa gagactagct ccatatcgtg 1301341 tgtaatcata aggacagcag ttccctctgc cttgatacgt tgaatcattt ccatgcattc 1301401 agccgccgtg cgggcatcct ggccaaaggt tggttcgtct aataataaaa cctttacgtc 1301461 atgcatgagc atagtagcta cgctcagtcg ccgtttttgc ccttggctga tcgcaaacgg 1301521 atgatgatca gccaaatgcg caagaccaaa acgctgcagc aggtgttgcg cttttttctc 1301581 agtttcagca tttgctttct ggccgaacag aagctcgtca tacaccgtat cggtgacgaa 1301641 ttgatgctca gggttttgaa aaacaaatcc catccgttta cgcaattctt tttctttata 1301701 tttctgcagc ggctgatcat agagaaggat tttgccgctt tgcggtttca tgagactggc 1301761 cagaactgat aggagcgtcg attttccagt tccgttcgga ccgacaagcg ccgttaaaga 1301821 gccttcgcgc aacgaaaagc tgatgtcttt gaaaatcgcc tgctgtcctc tcgcgaacga 1301881 aaggctgctg acttcaagca cactctcccc agaaggggct ttcttctttt tgacatgccc 1301941 ggcaggaata ggctctttga acagcatctc ttttgataaa gtaaacggca tactcagctt 1302001 ttcctgcaga tgacagacct ttggaatggc gatgcccaat ttctttagtg tctccgcttc 1302061 atgctgaaat agatttttcg tcaggccatc cagtgccttt ttgcctgatt tgtcgagtac 1302121 gatcgttctc tcaatccaag gcgcccattc atcaagctgg tgctcaatga cgaggaggct 1302181 gaaacctttt tcccgctgaa gatccttcat cagatgaacg aactcccgag ctgagaaagg 1302241 gtctaaaaga gaggtcggct catctaaaat aataagctca ggctccatcg ccaaaataca 1302301 ggcgagagcc actttctgct tttgtcctcc tgaaagggtt gagatcattt tttcttttaa 1302361 atgggtaatg cgtaattttt ctaatacggc gttgattttc tctgtcattt cttcttttgg 1302421 aatttgcaga ttttccagcc cgaacgctat ttcgtcctcc accgtcagca tgcagaactg 1302481 ctgatcagga tcctgaaaaa cgaccccggc atgctgagta atcgtttcgg aggtttcagc 1302541 atctgtgacc ggcttttgaa atagaaatac atgtccggac tgaatgccgt cgcaagcctc 1302601 cggatataga ccgtttaaac aaagggcgag cgagctttta ccgcatccgc tcggtcctaa 1302661 taataaaaca cattctcctt tttgaagctc aaacgaaatg tcttgaaaaa ccggtttctc 1302721 gtcttcttca taagagaagc tgagctgctc aaccgtcaga agctcatcaa aggcttgcat 1302781 gttctgacgc ccgcttccgt ttctttttca gttcctttcc gagtgccatt ccgtttaaca 1302841 cacctgtata agcgagagag tcgctgacag cttttccgag aagccccgcc aaaagcgcgc 1302901 cggaaatgag gcggatcaca agcataatga gcagataacc tggtgaatag gctgcatagc 1302961 cagaaacaaa gagatcatag ataaagctgg ctactgaaga ccccataccg gccagcataa 1303021 ggacagggag agagtatgct ttccagcgtg ttgcaagaaa tacagcctca gccccgagcc 1303081 cttgaacaat gccaatgacg atgaccatcg ggccagacgg atttcccagc aggcactcaa 1303141 cgagagcggc aatgatttca gaaacgagcg ccgcacccgg ttttcgaatc atgtacgcgg 1303201 cgatcacaga aacgataaac caaatgccgt aaattggttc ataggcgatt ggcccaaaca 1303261 tacctgcaag tacgtttccg aaatgtgtaa ataataaata aacaacggca aatacgatac 1303321 tgataacgga catgatgaca atttctttta ctttccagct tttcatgtta tccctgcttt 1303381 ctgttttttc ttgatggact gttagccgaa agattcacag tcatggtgat gtggtttgtt 1303441 tgctgctcag ccatgcggaa aacggcctcc aatgtgctga atacgtcatg cgcatccccg 1303501 tcaagctcgc tcgcgtaatg gacaccctgt acgaaagtgc cttgggcttt tgcaatgtcg 1303561 acagcctcca taatcaatcc catataatcc ggctcattca ttggataaag ggcaaattgg 1303621 cacggcgctt ccgccttcaa gcctcggaca gcatcttcat tgacacgctt atcacctttg 1303681 gaaagatatg tatccccctg tgtgtcaccc gggcatccaa tggaaaacgt gccgttcatg 1303741 acgatgtgtt gttcgctgtt tgctgcatga aggtaaatgg cttttgcagc atcgaataca 1303801 tgatcaatcg atccgcgtaa caccgtgctg atatggtcgg ttttcgtcca aaccttggat 1303861 gtatctgttt ttttcagcgc agacttgatc acactgataa aatcatccgt catcggatat 1303921 aaagagaagc gaaaaccggc gattctgctt gtaccgcaaa tatgctccat ttctccgacc 1303981 tcctgttttt ttggtaaaat aaaaaactgc atatcctaag ggaatatgca gtcatagatc 1304041 gattaagcgc acaaaaaaat acaccattcg gtcaacctgc acttccccac gctggtatta 1304101 tccagatcgg gtcataaggg atcaaagcgc gtttcttccg cgctttatct cagccaaaac 1304161 agcaccccta gtgctttccg tatacaattt tttattttga catcataata gatgataaga 1304221 atcattttgt aaacaacgaa atcatttttt tcatataggg acgggagagg atggtcaaat 1304281 ttggaaaaag gacacatatt aattgtggaa gatgaagaaa aaatcgccag ggttcttcag 1304341 cttgaattgg aatatgaagg atacagcgtc acgatcaaac acaatggcac agaaggtctt 1304401 gatgcggcag cggaaggcgg gtattccttg gtgcttcttg atgtcatgct tccggggctt 1304461 agcggactgg aagtgctgcg ccgcttgaga aaaacggatt cgcagacacc ggtcatatta 1304521 ttaacggcgc gagacagtat tcctgataag gtaacaggtc tggacatcgg tgcaaatgac 1304581 tatgtcacca agccgtttga aatcgaggaa ttgcttgcga gaatcagggc ggcgctgcgg 1304641 caaaatggaa caaaaactga agatatcggc acctttctta catatgacga tttgcgggtg 1304701 aacgaaaaaa cccgtgaagt gagacgcgga gacaaagagg tggaattaac gccgcgggaa 1304761 tttgatctgc tcgtctatat gctaaagcat ccgcagcaag tgctgacacg ggagcaaatt 1304821 ctaagctcag tatggggatt tgattatatc ggtgatacaa atgtcgtgga cgtctacata 1304881 agatacatca gaaaaaaact ggactatcct tacgaaaaac agctgatcca tacgattcgc 1304941 ggggtcggct atgccattaa ggggtaaacg atgaagctga agaccaagat tcatctatac 1305001 acttcgatat cactgttgat tttattaatt ttggttcata ccgcagtata tctcattttt 1305061 tcgtctgcgc tgacatcaaa ggatgcggcc cggcttgctg atgagacgga taacattgcc 1305121 gaagcgctgc gtgccgctga aacagaagga gtggctttgc aggatatgct gcaggcctat 1305181 cttccggcaa atggcatggt gcgtgtagtg aatggtgatc aaaaagccgt tatgacgatc 1305241 acaaaagaaa aagcctataa agattttcct ctctcttttc atagcggcga aacggcagat 1305301 gtgaggaaac ctgacggcaa gctgtttgcc gaggctgctg ttccggtgat ttggaccgat 1305361 ggacaagtcg tgtctcttca gctggttgaa agactggaga acacagaaga gagtctgttt 1305421 ctgctgaaaa tcatcttaat cgctgcaagt gctgctgtct gcattgcttc tttttttgca 1305481 ggcagcttgc tagcccgccg aatcatcaat ccgatcagac gattaatgat cacaatgaaa 1305541 gacatacagc gagacaaaga atttaaaacg atttctttag aaggacagtc caacgatgaa 1305601 ttgtatcaaa tggggctgac atttaatgaa atggcaatga tgctgaagga gcactatgat 1305661 aaacagcagc aatttgttca agatgcttca cacgaattga aaaccccgct cactattata 1305721 gaaagctaca gcagcctgat gaagcggtgg ggtgcaaaaa agccggaggt gcttgaggag 1305781 tcgatagaag ccattcactc agaagcggtg catatgaaaa aactgaccaa tcagcttttg 1305841 gcgctggcca aaagccatca aggactcgag gttgatctga aaacaatcga tctgattaaa 1305901 gcggcgcgcg cggttatgca aacgctccag tccgtttatc agcgtgacat attgcttgaa 1305961 acagataaag agagcctgct tgtaaaggca gatgaagaac gcatcaagca gctgttgacc 1306021 attttgcttg ataatgcaat aaagtatagt gaaaagccta ttgagatgtc agccggaacg 1306081 aggaatggac ggccatttct atcagtgagg gatgaaggca tcggaatacc tgaggagcat 1306141 atcccgcatt tgttcgaacg gttctaccgg gcagatgagg cacgaaacag aaaaacaggc 1306201 ggaacaggtt taggcctttc cattgccaag caaatcgctg atgagcatgg cattgagctg 1306261 tctgtcaaaa gcaagccggg acaaggaaca gctgtcacca tgcaattcag cgaacagaat 1306321 gggggaggcc gatgactaaa acaataaaaa cagtatcttt tgctgcagca gccattttag 1306381 ttgtcatcat ctgtacgttt ctcatcattc ggcaaaccca tgagaacgta ttgtcaaagg 1306441 agactgtcgt aaaaaaagtc gaagcctctt atgaaggcaa ggtcacgaaa gcaacacaat 1306501 caaaggataa aaaaacatat gatataaccc ttgaaaatcc aaagggaact tactttgtaa 1306561 aagcagacgc aatatcggct gacattcttt caatgaatag agtaaaagca gtgaatccat 1306621 ctgccatgac agaaaaagaa gccgagcatc tcgcgcttga gcgggtgccg ggaacggtca 1306681 aaaaacaaac acggcaaagt caagttgcca cttataccat acaaaaagaa gacgggaaaa 1306741 catacgaagt gaaggtagac atgcaggcaa aaacagtctt gtctgccgat caaatcagca 1306801 gcaaagatca acaaaaaacg ccgattacga aaaaagaagc caaaacaatt gcagagcgaa 1306861 aaacgggcgg aacagcggat gacgcagatc tcgaagaaag tgagggcact ctcatctttg 1306921 aagtagacgt tgatcttcct gataataagg aagcgacagt gaaaatcaat gcctacacag 1306981 gaaaggtagc taacattgtg tatgaagact gacggtttct catcaaattc tcatcttgct 1307041 ctcgttttcc tttcatgttg agtatgtaaa ctgtactcat acaaaacaaa ggagggctca 1307101 caaatgctca agaaaaaatg gatggtcggt cttttagcag ggtgcctagc ggccggagga 1307161 ttcagctaca acgcgtttgc cacagaaaac aatgaaaaca gacaggcttc ttctaagacg 1307221 gatgcactca ctgaacaaga agcagaagca attgctaaaa cagttgttga cggcacagta 1307281 gaagacattg acagagacct ttacaacggc aaagaagtct atgaagtgga gattgaaaaa 1307341 gaaggtgaag actacgacgt ttatgtagat attcatacaa aacaagcgct taatgacccg 1307401 ttaaaggaga aagcagaaca agtcgccata accaaagaag aagctgaaga aattgcttta 1307461 aagcaaacag gtggaaccgt aacagaaagt aagcttgacg aagatgacgg tgcttacatc 1307521 tatgaaatgg aaatccaaac gaagcaagga actgagacag aatttgaaat ttccgcaaaa 1307581 gatggacgca ttatcaaaca ggagatagat gactaatcaa aacccccgct gcagcggggg 1307641 tttttcatga taagaaacct tcttttggac aatctaagta gaaaaggagg cgaaacgcat 1307701 ggaaaagaaa gaggagcaat acatcaatca ggctgaatat gtccctcatc cgacgaagga 1307761 aggagagtat gccttatttc ttcatgaaac gtatcatttg ctttctgaag atgacgagac 1307821 acaaacaaca gaataagggc ttaggccctt gttttgttcc gtaattgtga tgtaagcgca 1307881 tttattactt ttttgagttg acatagcttg tttttttctg taatctcagt gtgtcaattc 1307941 aattaggaac ttcgttaggt gaggctcctg tatggagata cgctgctgcc caaaaatgtc 1308001 caaagacgcc aatgggtcaa cagaaatcat cgacataagg tgatttttaa tgcagctgga 1308061 tgcttgtcct atgccataca gtgctaaagc tctacgattg aaggcgcccg cacgcttttt 1308121 ttgccgtgct tctttcacct tcaatcccga aggctttttt tatgccttta aaacgaaacc 1308181 aatcaaagga ggtgcggagt atggattctc cccattcgag tcaatctgaa gaagtaccca 1308241 tatactatga cagcaagaca attgattaca cgatgaggag acgaactgcc gcaccttctg 1308301 gcgaggccgg cacgtctccg tagaggaggt acgagtcccg atggttcaaa acatgaccta 1308361 tgacgaactc attttacgca tcattatttt actgcgagac gggaaaatca gggattttag 1308421 aagtgttatt gatgagcttc agccctatga catggcattt atttttaaag aaatgccgga 1308481 aaaacatcgc gcccgctatt tatcttattt aactgtagac gatatcactg atatgatcgg 1308541 ggagctggaa cgcgaatttc agcttgtcgt cttaaataaa gtcggaaaaa caaaagcaac 1308601 actggcgatg aacaaaatgg acaacgatga cctcgctcaa ttgcttgaag aaatggacga 1308661 agaactgaag gaacagcttt tatccagcat ggaagcgtca gaatcaaaag ctgtacagct 1308721 cttgatgaat tacccggctg attcagcggg acgcatgatg acaaaccggt atgtgtggat 1308781 ccctcagcat tacacggtaa aagacgcggt cgtcaaactg aaaagcttcg ctgaaatagc 1308841 tgaatcgatc aactacttat atgttattaa tgaaagcaaa cagctggttg gggttctttc 1308901 ctaccgcgat ttgattctgg gtgaacctga agaaaaggtg caggatttaa tgtttacccg 1308961 cgtcatatca gcagatgctc ttcaggacca ggaagaagtt gcccgcctga tagaacgtta 1309021 cgattttttg gcaataccgg ttgtagaaga aaacaacgtg cttgtcggca ttgtgacggt 1309081 tgatgatatt atcgacgttg ttattcggga agctgatgag gattacgaaa aatttgccgc 1309141 ttccggtaaa gacatcacct ttgacacaaa agcttacgtg gcggcatacc ggcgtctgcc 1309201 atggctgatt ttactcttat ttatcggact gatttcagga agcattatca gctattttga 1309261 agacgcgctg aagcaggttg tcgcgcttgc gtttttcatg ccgatggtgt cagggatgac 1309321 aggaaatacg ggaacacaat ctcttgcggt tgtcatcaga ggtttgtcta aagaagaaat 1309381 gaacaaaaaa acgattgtgc gcctgatctt ccgggagttc agaacaagca tttttatcgg 1309441 agcggtttgt tctgtgctga ttgcgattgt ttctatcata tggcagggga atgcgctttt 1309501 gggatttgtt gtcgcctctt cactgttctt aaccttaatc atcggcacga tgtcaggaac 1309561 gattatccct attattttgc acaaactgaa agtagacccg gcgattgctt ctggaccgct 1309621 gattacaacg ttaaacgata ttttatcttt attaatctac tttggcattg ccactgcatt 1309681 cattcactca ttataaacgt aaaaagtccg tctcaactgc gagccggact tttattattt 1309741 aacggttttt gtaccgaaag tgagcattaa gctgcccctc cagcattttt ttccgcactt 1309801 gcggatcgtt ttttaacatc tgttcttttt tgcgcatatc ctttaaaatc tctgccgtct 1309861 gtacgccgtc ttcacgctta ttggcgatat ccatcagccg ctccacatcg gcaaaggagt 1309921 attttcttgt cccccttgaa gaacgctgcg ggtaaatgag ctttcgttcc tcataatacc 1309981 tgatctgtct tacggacaat cctgtcaatt cactcacaat tccgattgaa atcacttttt 1310041 tgtctttata agaatgatct tctgtggtca tttttccacc cctggatgtc ttttgataat 1310101 agtatataaa aaacaaagag aaaaaacctg acgcttgtca tattttctaa catcaaatag 1310161 aagatttttg aaaaaatacg gaagaaaaat taacaagaat aatgcgtaac acccaagcgc 1310221 gttttatcct ttatgtaacg aatcaaacga ggaggaagga taatcatgga ggaagaaaaa 1310281 gcagtctcac tggcaaaaga aattatagag ttggatatca agcgtgatga aatgctggag 1310341 acgtttatgc agcttgccgg agaacaggct tttcaattat taagatcggt tcaaaacgga 1310401 caataccgaa aatcttcgta aacataaatt ctttacatta gattcatacc acgttcattt 1310461 aaaaagagta tcttttgtat aggatacctc aaaatgaagg aggacgctat gagtaattta 1310521 ttgaaatccg ctttagaaaa agaacgacgc cattattctg aaaaactcta tcagataggg 1310581 gtttataata aagaggtcat gaacaaaatg acgatttctg agcttcggaa agaatacgct 1310641 tatttctttc gaagcattac aaatcataaa aattatcctt atacaagata atgtataagg 1310701 atttttttgc ttttagaagg aatttctcga attatagcga atacgtatag taagggactg 1310761 aactcttatt atatgtaagg gttttcatta tttttttata aaaatcctat atacgaggta 1310821 gatatgatga gattatcgtt taacgaagaa gaagttgagc gtgcgatgaa tttgtacaga 1310881 gtttttgcaa gggctttcaa aagtgtgtcc gaacatagta tccgtgatag caaagagcac 1310941 ggttttaatc ccactgaatt tgctgtactg gaactcctgt acacaagagg cccgcaaaaa 1311001 ttacagcaaa ttgggtcgag acttctgctt gtaagcggaa acgtcacata tgttattgac 1311061 aaactagaaa gaaacgggtt tttagtaagg gagcaggacc cgaaagataa acgctctgtt 1311121 tacgcacatt taactgacaa gggaaatgag tatttggata aaatttatcc gattcatgca 1311181 ctgcgtattg cgagagcgtt ttcaggtctt tcgcctgatg aacaggacca gctgatcgtc 1311241 ctgctcaaga aagcaggcat acacagccag catttgctgt ttcgttaact attctacact 1311301 ctctatttca ggagagtgtt tttttgtttc catatgattc tttttaaaac atctttaatc 1311361 ttcctatcag acatttcgcc aaggtatcca ttgacgtgtt ttttatactc cttcatctgt 1311421 tcgttcgatt gaaaaaatgc cgcgatatac tcttctgctt tctgcatgtc ccagtttctc 1311481 atatctgtga cgagtttcct ttcatgtaga aggtttaaat tcatttcctc ctgtcccggc 1311541 agtgcatgat aaataaatac cggaagccgt ttctgtaagc attcactgat ggtcacgcct 1311601 ccgggtttag tcatgatgcc tgtcgcctgt tcgtacaaac ggttcatctc tgctttgctg 1311661 tgaaggtaag gaatcgcctc aatcaagggg tggtgtaaac ttttgacata ggagtagagc 1311721 ttttcgtttc tgccgcataa tattttgtat aagatctttc cgcctggcga cagttcctgc 1311781 acccatttta aaatcccacc gacccccata ctgccccctg tgatgatgat ggtatatggc 1311841 gggtggtgct gcaaggtatc tgctgattcc atttcaaaat tttggtgaac tggaatgccg 1311901 gtcaagtata tgttgttctg atcgataccc tctgatatta gctgcttctt tacttccgtg 1311961 ctcggaacaa aatggtaatc aatgttcttc cgtccccata attgattcac gaaaaaatca 1312021 gtgtatacat tcacaaccgt cagattcgga tattcaggct ttagtcggtt cagcagataa 1312081 gaaggcagcg catgtgtgca gaaggcgata tcaggctgtt tttcttggag gatgtgcctc 1312141 atttgctgtg tgaacagcca ttcgtacatg aaatagcgtt tgtcatgctg aaattctccg 1312201 caggcgagga gcctgtaaat gccgctgtac gttttcggga aatattgaat ccattttaaa 1312261 taagccacgg aggacaattt ttctaaccgc ctatacgaat gtgaaaagat atcaatcttt 1312321 tcagctgcca gcccttgaga ctctaattca gcctgcaatg catcagccac atgatgatgg 1312381 ccggtggaaa tgcttaaaaa aggaaaaatg agaatgtttt tcatgacagt cctcctaaaa 1312441 aaatatggca actatatttt gaggagaacg ttcacaaaat ataagggtgt ttttgatcat 1312501 aaggaaggtg aaaagatgaa aacttgtttc ctttccatat ggagagtggt tgatccgatt 1312561 tatttctttt tttcaaggct aagcttgatt gacaacgatc aaaaaagcgt ttttcgagtc 1312621 aggctgacga agtacaaagg acatcatgtc gtgcttagcg acggaacgca tataagaaaa 1312681 aatgatgtgc tcgttaaaat ccacctgcat aacataaagc tgatcaggga gctgcaaagc 1312741 attgagagcg cagtcagaaa gggaatcatt atttatcaga aagtatatca atcgatgccg 1312801 cttcttcttg actatatcaa caatcataaa aaaagcgaga aaatcaaagg aatcattggg 1312861 attacaatgc ttgacaaagg tgtggaaagg ctcggctttg atgtgatcac cccggtgaac 1312921 cctttttaca gatgctttaa aaaagtgtct catgtgccga ttttatattt gacttcaaag 1312981 cctgtgagct tgcggcattt accgaattca tcctatttgt ttatctcaaa agaaaagctg 1313041 cagaaaacct atcaaaaaaa agactgatgc ctcggtcagc acagtctttt ttgattaaat 1313101 ctgatgaaat gtcacttcag ggcggcttcc gacacggata tttacgccgg tttgtcccaa 1313161 gccctcgctg atataaaatg gtttatcgtg atgataatga aggcctttaa tcatgttcat 1313221 tcgcacgagc tttcccattt tcaccaaatg atacggtttt ggccagtgaa tttgcccgcc 1313281 gtgaaaatgc cctgacagca ggtaatcata atgaacatct ttcatatcca gaataatatt 1313341 tgggtcatgt gttaagacaa gatgatagcc attttccaga ctttgataag agccggtgat 1313401 attactccga ttcgtactgt aatcatcaat gccgataata ttgactggtc ctgcagccgt 1313461 ctcgattcga acatgttcat tttgcagcgt gatacagccg ttttcctcta aaactcgctt 1313521 caatctctga aagtcctctt ctttcaatac ataatcgtgg ttaccgaaca ccgcgtacat 1313581 tccatatgca ggctttagct tttgcaaggc gttcaagtaa cctgccagtt tcggaatatt 1313641 acgtttccga tcaagaaaat ccccggtaag agcaatgatg tccacaggct gatcttttgt 1313701 taaatgatac agctcctcag gtgagactga aatgttttcc aagtgaagat cagataaatg 1313761 aaggatattt aatttttttc tggctggaag gccgtctttt tggtcgattg aaatggtgtt 1313821 gactttcaca tcttttgtat tgcggttcgc tttatataga aatggcacaa atacgagtat 1313881 ggccaatgaa agtaagattg taaacaaaat atatcccctc ccttctatca gtatagtaag 1313941 tgatcaagcc ctatggatag cgggaattaa tgggtagaga caggttgaaa aacggattgt 1314001 catatgatga atgatttgga agggaaaagg gataataaat tttgacacat gaggcagaac 1314061 atgccgacgg agtcagaata acaaatggat gtgtaagcaa tgttacgatt gatgagacaa 1314121 caaaaaaaag aaacatatta tctctggatc gcattatttc ttcttttatt gtatgtatcc 1314181 ccgcttttta ttttaaagga agatgcccat atccgggtcc acgataattt agattccaac 1314241 atcgcttggt acaaggttct ggccgatagc ggagaaatcg tcggcaaggt tgacgctgcc 1314301 attccgcaaa tcattaacgg gctgccccgg gatgcctttg gcaccgagtg gagcggaatt 1314361 gtttggctcc atgctttctt ttcttccatg accgcctatg caataagcca gacggttaca 1314421 agagttgtcg ctttttttgg aatgtatgtg ctgctgaaga aacatataat cccggaacca 1314481 aaagcggctt tcatccgaat tggcgtatcg cttgcatttg ccttaacacc gttctggcct 1314541 tcgggaatgc tgagtacgct tgggtaccct ttggcactgt gggctttttt aaatatccga 1314601 aaaggggata tctcatggag agagtggctg acgctgggct tgctccctct atactcaagc 1314661 tttgttctag gcttcttctt tttcctggca gggatggcgt gtttttggct gtatgatgcc 1314721 attacaaaaa gaagatggaa tttgatgttc ttaggcagta ttgcatttat gacgagtatc 1314781 tatcttttcg ttgaatatcg gcttgtctat tcgatgctgt ttgagcacgc accgatgcat 1314841 cgtatcgaat ttatctcatc taggcatgac gtttggcatt ctcttcgact atccataaaa 1314901 aactttgtct atggccataa tcatgtgatg accgttcata ccgttgtcat ccttccgatc 1314961 ctgatggtcg tatttgctgc tctgctgttc aaacgaaatc ggacaaagcc agaaaatgtt 1315021 tatctgtttt tatgtgtgct taattacggg ttgtcattat ggtatgcgtt ttggttcaac 1315081 aaaatttggg ctgttccaaa gcagaaattt gcttttttag cagaatttaa ttttgcccgt 1315141 tttcattttc ttcggccgct tgttatatac gtgagctttg cgcttgcttt atatctcatt 1315201 tggcggatgg ggaaaggatg gaaatggctt gtgtacgccg cagtcgctgc acagctgatg 1315261 gtgttggcgc cttttaatga agaatatacg tatggtgttc attacaacgc gccgacattc 1315321 agggagtttt atgcatcaga gcaattcaaa gagattaagg aatatatcgg acgtccgcaa 1315381 gattcgtata gggtggcgag catcggactg catccgtcta tcgcccaata taacgggttt 1315441 tatacgttag atacgtataa caatctgtat ccgctctcat ataaatatga atttagaaaa 1315501 atcatcgaaa aagagctgga aaaaaattct cggctgaaac aatactttga tgaatggggc 1315561 agccgctgct acctttttgt cgatgaactc ggtaaacgat atgatttcaa aaagaactcg 1315621 aagaaaacga tcaacaacct tcaattaaat acagatgtat ttaaaaaaat gggtggacgg 1315681 tacatttttt cttcagttcc gatcatgaat gctgaacaaa accatctcgc gctcgtaaag 1315741 acgtttgacc ataaagattc cgcctggcgc atttatttat atgaaacaag ataaggagga 1315801 tatcgattga aacagtcaca gccagtatta accatcgtcg tcccgtgttt caatgaagag 1315861 gaagtgtttc aagaaacaag ccatcagctg acagaggttg tagatgattt aattgaagaa 1315921 aaattaattg ctgaagacag taaaattctg tttgtcgatg atggcagcaa agaccgcact 1315981 tgggctttga ttgctatgga gagcataaga aacaagaagg ttaccggctt aaaattagcc 1316041 tgcaatgtcg gccaccaaaa agcgctttta gccggattgc ataaagcgaa gaataggtca 1316101 gactgcgtca tttcgatcga tgctgatctt caggacgaca tctctgtgat ccgggatttt 1316161 atgctgaaat atcatgaggg ctgcgagatc gtttacggtg tacgccggag cagaaaaacc 1316221 gatacctttt tcaagcgcac gaccgcgtta gggttttatc gtctcatgaa taaacttggg 1316281 attaaattaa tttataatca tgctgatttt cgtttaatga ataaaaggtc ccttgaagag 1316341 cttgagcgtt atccggaagc gaatctgttt ttaagaggta ttgtccccat gatcggcttt 1316401 aaatcggccg aagttttgta tgaccgcaag gaacgctttg ccggcaaaac gaaatatccg 1316461 ctgaaaaaga tgctatcctt cgcttttaac gggattactt cattcagtgt cgcaccaatt 1316521 cgattcttta cgcttttagg gtttgttttg tttttcctca gcgctgtggc agggattggc 1316581 gcgtttattc aaaagctgct cggccatacg aatgcaggct gggcgtctct tatcatatcc 1316641 atttggtttt tgggcgggct gcaattgatg ggaattggaa tcatcggaga gtatattgga 1316701 acgatttttt ctgaagtgaa aagacggccg aaatacgcga ttgatattga tttgtataat 1316761 gaacagctga gcccgcttca gcgccaggaa aaagagcggt tagaaaaaaa gtacagttaa 1316821 acacggaaag agctgacttc attagtcagc tctttttctt caactgatgc aatatagcgc 1316881 taagcggttc gtcttgcggg ttgcggtaaa aatcaaaaaa tgggcagccc tgcttcttaa 1316941 ttcgatcgat gaccgtatca attgtaaaca gagcgggtgt taaagatgat tgcacctcat 1317001 gccagtagag cggggctgca acagtcccaa gctcatttcc tctcgttgaa tagggacaga 1317061 taatcgtttt tccttctgca tgctgcaaat aatcaagata caatttgcag tgtctgtttt 1317121 taatcaagcg ttcagtggta aagagctcgg gaaatgcatt ggtgcagtac tctgcgatca 1317181 gctgcgtaaa ttggcgtgtt tcttcatacg taaatgcctc gggagacaag ggaatataaa 1317241 gctggatgcc tttgttgccg gacagcttcg ggtacgatgt gatgccaaag gaatccaaca 1317301 gccgcttcag ttcatttgcg gcctgcacgg ccataagaaa gtcatctcgc gaaggcgggt 1317361 ctaaatcaat gacaatctca gccggacgcc tgcttttaat ggtttgaaaa ggaacgtgaa 1317421 actccaaagc aagctggttg caaagccata gcaatgtaga catatcctca cagacaatat 1317481 gttcatggct tccatcatag aaagactgaa caaaatccgg cgcatagtcc ggcttgtttt 1317541 tttggaaaaa tgattcgctc ctagatccat gcggatagcg gatgacggtg acagcccggt 1317601 ttttcagaaa tgggagcagg tagtcactga cttcaatcat atactgaata aaatcttctt 1317661 ttgttttttt attcttttca aatatgattt tatccaggct tgtgaactgg agctttgggt 1317721 gaaccggttt ggagtgtcgt atgacttgcg catacgtgca ttcggtccag tccatttgga 1317781 attcgaaacc gataaacgat acctctctta atgtgccttg gagaattgtt aagtattgaa 1317841 cagctgcaca aatcgaaggt tcaagcgtaa attcgcctga gggtgtttga tgtccgtgct 1317901 gttccataat ctcgcgtata gcgctttttt cctcatcacg cattccgtgc gagacagagg 1317961 caatcggtgt cattattccg ttttttaaca ccgataccgt cagaaacccg ttgttagggt 1318021 tgaaccctgt tatgcaaaca taagcttgtt taaagttttt atatttgagc caatcggacg 1318081 accgcttctt ttcaagccat ttgctgtttg ttttcttcgc tacaattcct tctccgtcat 1318141 attttattac catctcccag agttgatcaa aatgatcata acagggaatg gattgaatgg 1318201 tttcttttgc gtaaggatct ggagatgcag gaagctttgc tgcggatatg agttcacgca 1318261 gcgatttttt gcggtccaaa tacgaaagaa gcgttacatc ttctccgctt cgctctaaca 1318321 aatcaaaggc gagaaagcag cacggccgcg cgtttgccga ttcctgaatc ttgtctggcc 1318381 ttttcaaacg cccccgcact tgaaggtgtt caaaatctgc acgacaggga ttcaccaaac 1318441 atacgatttc accgtcaagt gtcagcggaa gctctttttc taggtgctga aaggcagttt 1318501 tggcgaattg tgtgatttca gggaaggtgc tgctgagctc cacaccattt ctgctggtta 1318561 aggtcacacc tgaagaatgg atgcggagaa tacagcggta cccatcatat tttacttcgt 1318621 aacgccattc tgctccgatt ggcggtgacg aagttaagac cggctgcatg gtaaacgcca 1318681 tgcgctatga tgtgccggag gctttttttc tagttgtttt ttgtttttta tctccggctc 1318741 ctttcggttc agcggcttgt gcaggtgcgg cagccggtgt ctcccggttc ggccttctgg 1318801 ttctgtcgat gctggcttgc agagcgctta ccaggtcaat gacatcttca cgaggtggcg 1318861 ctttatcagg agtgacagcc gtttctttat tttctagctt gtcgttgact ctttgcagca 1318921 gcgcctgtcg gtacgtgtct tcatatttct caggctcaaa cttagcagtc agttcatcta 1318981 ttaatgtgat agcagtttgc agttccttat cgtttacatt cgattgatca ggtacacctg 1319041 ggacttgagc ggcgcttctg acctcatcgg gataatggat agactccatg acgatacaat 1319101 tttcataaac gcggagaatc gccagctgct gctttgacct gattgtcata ttggcgatac 1319161 cgatctttcc ggttgagcgc agcgcctcac gcagcagggt ataggccttc gtcccattat 1319221 ccccggggcc gacaaagtag gagcggttaa aataaatcgg atcaatttcc tgaagctgaa 1319281 caaagtcaac aatctcaact gctttctcct catgctcctg ttttaagctt tttaaatctt 1319341 cgtctgtcag cactacatat tttcctttta catattcata tcccttcaca atttcatcag 1319401 gactaagagt tttttcgcaa tttgtgcaaa ctttctcgta tttgattggt gcgtgatcct 1319461 ctttatggag gctgcgcagt ttaatatctt tatcttctgt ggccgcatat agcttgatgg 1319521 ggatgtttac taatccgaag ctgatcgatc ccttccacat tgtatgcata tcgataaacc 1319581 cctttttttc tttagtgtga agagaaggag tacgattcat gtgtagtaac ttatgggtga 1319641 aaaaaagccg gcgctgttat tgcgacggct gttcaataat gaattgttcg aattgttccg 1319701 gaggtattgg cctgctgaaa aagaagccct gcaaatggtc gcagcctttt tcaaaaagaa 1319761 gctgcttttg agctgcattt tccacacctt cggcaatcac ctgcaaagac agctgatgcc 1319821 ccatggcaat aatagctccg gtaatttgct ctgatttagg atgggtctga atatcgtcaa 1319881 taaatgattt gtcaatcttc agcctgtgaa tcgggaagtc cttcaaatag ctaagagagc 1319941 tgtgaccagt accgaaatcg tcaatactga ttctgattcc taattctgtt agggatgaca 1320001 aaaccttttt ggagtgattg agattgtcca ttgtcatgct ttccgtcacc tccacttcaa 1320061 gaagctgcgg aggaagctgg tacttattaa gcgtatcctt gatgagggga atcagatctt 1320121 tagattgaaa ctgtctggcg gaaatattaa tggcgacaga aagatcatag cctttgtcat 1320181 gccaaatcct tgcctgcttg catgcttcat ctataatcca ctttccgata tcaataataa 1320241 gtcccgtttc ttctgcaaca ccgatgaatt ctccgggcgg acgcagttgc ccgtctggtg 1320301 tcacaaggcg tatcagtgct tctgctcctg tcattttttg ttttttcaca ctgaattgcg 1320361 gctgataatg caagacaaat ctatcgtttt cgattgcttc tctgagtacc atctcttggt 1320421 taagcttaac ggtttctttg ttgccgattg aaaaagaata gtatctgtat ttgcttttgt 1320481 ttcgttcttt agccgcatac atcgccatat cagccttttt catcaattca aggccatccg 1320541 tcccgtcttt tggagatatc gcaatcccga tactgacaga tgtgacaagg gtgtgatctt 1320601 gaattttgaa aggttttttg aatttttgga taatttttct tgctaaaaca tctgcttcgc 1320661 ctgttcctgt attggcgtct gttaatataa taataaattc atcaccgcca agacgggcga 1320721 taaatccgtt atcagggact acagatgaca ggcgtttagc tgcaaactga agcaattgat 1320781 caccgacatt atgccctaat gcatcgttaa tcactttaaa ccggtttaag tcaagaaaga 1320841 atacaacagt gttataatgc aaggaatgct cgcgattcag cacctttgtt agatgagaga 1320901 tggcatgcct tctgttaggt aagtctgtaa gcgaatcata atgagccatt ctatggattt 1320961 ctttttctgc tttgtactgc ttcgtcatgt ctttacaaat gacataaatg ctgtctagtt 1321021 cctgattgac ctcaacaggt ataagcgtaa tatttaagtg aaactggcct ttttcagtga 1321081 taagatcgct atcgctgttc atcgcttgtt tatctttttt aacttgctca aaaaggcgct 1321141 taaccttcag tgatgtgtaa ttcctccagt catgcatgct gaagccaaat ttgctgatca 1321201 tttcctcacc agcgtgattg gaagatatta tgtctccttc taatgataaa ataaaaattg 1321261 catcaatatt gtggacgatt aaagactgaa atcgctgttc gttatccttt atgcgttcgc 1321321 tctgtttaat aaactttcga tctgcatggg aactgaataa caataacgtt tggatacaaa 1321381 aaataattaa agtaacaaaa attgaccaat gaaacgtttg cacctccata tggcttccgg 1321441 gcggagccat gtccttatgg aaagttgccg caagcatccc tgtgtagtgc atgcccgaaa 1321501 tcccaatgcc cattacaatt gaactgacgc ctttatagaa tataagatgc tcagaatgtt 1321561 tttttacggc caagtcaaag aatattttta acgagacgaa agaggctgca atcgcaatga 1321621 taattgaaac tgtaaataaa ataggttcgt aaataatcat tacccgggaa atggcagaca 1321681 ttccgatata gtgcatagaa gcaatagatg cgccaagcac aactgatccg gtaagcagtc 1321741 tgtaatatgt aagaatgtgc cggctgacaa aatataatga cacaaatgat cccgaaacag 1321801 atgcgccaat ggctgccatt aaaggcatga attcatattc catcggcatt tccatatgga 1321861 cggccatcat ccctacaaaa tgcattgacc aaataccgaa tcccataata agtgagccgc 1321921 cgatcagcca aattttactt tttaagcctg tattgatggt gactttcctt gaaagttcaa 1321981 gggaaatata cgaggcggta caggcaatta gaatagataa acatatgaga gtcgtattat 1322041 atgtaacgtg tatttccaaa tggagattcc ccccgtatcg tgtgttccag tcttgttgac 1322101 tctctttatt atcggctgct taaccgcaga gtttcagcct tcaaaacgat agaaatacga 1322161 gggagatcta tttttagttc aactgaccgt gaaaaatgtg ttaaaatcat cttgatgttt 1322221 tccgaaaaga gaaaaatgta tgatacataa acatgaaaca agggagttgg tggctatcga 1322281 agagctggtt atgtcatgga ttgaagcatt taaaagctta tcttattttg gaatatttct 1322341 agcgctcagc attgagttta ttccggccga agtcgtcttg ccgcttgcgg gctattgggt 1322401 atctaaaggc gatatgacac ttgctggcgt tgttttggca ggatcgcttg gaggagtggc 1322461 cggtccgctt acgctgtatt ggataggccg gtacggagga aggccgtttc ttgaacgttt 1322521 tgggaagtat ctctttatta aacctgaagc gcttgataag tcagataatt ttttcaaaaa 1322581 acatgggggc tttgtcgcct tcagcggccg tttcttgcct ggtatcagga cattgatttc 1322641 cataccgtgc ggaattgcaa aaatgaatgt ttgggtgttt tcgctttata cattcattgc 1322701 tatgcttccg attacatttg tatatgttta tctcggtgtg aagctcggtg aaaattggaa 1322761 ggcagtcggc tctattcttg atcaatatat gcttccgatc gggatagcga ttttggcgct 1322821 gttcctgctc tacttactga tgaaaaagag gaagaaacgc acgcactccg aacaattatc 1322881 tgtatttttg aaaaataaac gttgacaaat cactgcgctg cgcatattat tgacgtataa 1322941 aatcatattt cttgaaatcc caaaggggag tagcgtccgg aatgtattcc ggaaacaaag 1323001 tcgtcatttc atggattgta tccatcggct ttgttggcat gcctgaattc atgtctagca 1323061 agacctttgc cttatgtcgg caaaggtctt ttttgcatgg tccggccggc ataagatcgg 1323121 atgaagagaa agaaaacaac ttttttggga gggtatcatt tatggatgca gcattattat 1323181 tagagtatgg ttgggttctt ctcgtcttga tcgggctgga agggatttta gccgccgata 1323241 acgcgctggt tatggcggta atggtaaaac atttgccgga ggaaaaaaga aaaaaagcgt 1323301 tattttatgg attggcaggg gcttttgttc tgcgatttgg ctctttattt gcaatttctt 1323361 tcttggtcaa cgtatggcag gttcaagcga ttggcgcgat ctatttgctg tatatctcag 1323421 caagccactt attgaaaaga tatgtattta agaaagaaga cacacataaa gagacgaagc 1323481 aaagcggttt ttggccgact gttttaaaag ttgaactggc agatatcgcg tttgctgttg 1323541 attccatctt agcagcagta gcgctggcgg ttacacttcc tgggacatca ctcccgaaga 1323601 tcggcggact tgacggagga caatttctcg tcattttggc cggcggtatc atcggactgg 1323661 tgatcatgcg gtttgcggct tccatgtttg tgaagttatt aaaggaacgt ccaagcctag 1323721 aaacagcagc ctttgtgatt gtcggctggg tcggagtgaa gcttgcttta tatacgcttg 1323781 cccatcgcga catagcggtt gtttctgagc actttatcca ttctggaaca tggaagctga 1323841 tattctgggg tgtcttagca gcaatcgcgg tttgcggctg gtttatgtca ggtgggaaaa 1323901 aacagccgga gggtgcacaa aacgaacaaa aaaacagcac ccgtgaacgg gcgtaatctg 1323961 aaagactctg cttaaaagca gagtcttttt gtgtttgaag cgttttcata agcgaaataa 1324021 aataacattt ttataacatc tttgttacaa aaaacacgca taaaaccccc ttaattcttt 1324081 agaaaggcac gaaatcatgt atagaacgtc agaatggttt gtcataattg agacattgga 1324141 aatcaatatt tctttttctc ctttgcgaat ccctatcaaa ttagctatca ttaatgagta 1324201 gttataggga ggaactgagg tgaaaccagt gcttagcctt ttgtttaaat tgggaaaaaa 1324261 gaagcaaaca cttgaaaaag ctgttgagag tatacaaaaa ggcaataaag atctgcaaaa 1324321 tgaattaata cagcaatata agccatttat cgcaaagacg gtttcatccg tttgtaaacg 1324381 atatatagat gaaaaagacg atgagttcag tattggactg atcgcgttta atgaagctat 1324441 agaaaaatat tcacctgaaa aaggaaattc tctgctcgca tttgctgagc ttattataaa 1324501 aagaaaagtc attgattaca ttagaaaaga agccagaagc gcacaaaata taaatatcga 1324561 tttacaggaa ggagacgatc aggagtcatc acaaagcctg attgaagccg agctttccat 1324621 tgatgaatac cgccgtcaga ttgaacagga gcagaggcgg gaggaaatcc tctattttca 1324681 aaagcagctc aaggattatg gtttatcgtt taaagaactg cttgaaaatt ctccaaaaca 1324741 cacggatgca aggcaaaacg ccataaaggt ggcaatgacg cttgttgaac atgaagaatt 1324801 ggccgctatc ctgtatacaa agaagcagct tccggtcaaa cagcttgaac agcttgtctc 1324861 tgtaagccga aaaacgattg agagaaacag aaaatatatt attgcgatgt gtattatcat 1324921 tacgggtgat tatatttatt taaaagatta tcttaaaggg gtgctgcact catgagaaga 1324981 gggattatag tagagaaaaa taaaaaattc gtcacgttgc tgacccctga cggacaattt 1325041 ttaaaagcca aaaatgatcg acacagctat gaaatcggag aagaaatcat gcttccgagt 1325101 gaaacacgca tgggcagaag ggccagcttt tttgattttt ttaaactgcg ccctttcaaa 1325161 atggggattt ttacgatgac tgctattatg ctctttattt ttatagttct ccccgttttt 1325221 tctaataata aggcctatgc gtatatgaca atcgatatca atccaagcgt cgaaatggcg 1325281 ttaaacagcg attatgaagt gattgaactg acgcctctaa acgatgaggg acagaaagtc 1325341 gtgaatgata tagatgattg ggagaagact gattttaaaa aggtgattga cgatattata 1325401 accgactgca gtgaacacgg gtatgtaaaa aaatcgaaag aaatattgat ttccactgtt 1325461 tatgaaaaca cagaagacaa tacatataaa aaggctgtga aaaaacagct gaatgatgtg 1325521 actgaaaaat ataaaacgac ataccgcatg gaatctctcg agtcagatat gcaaacgagg 1325581 gaaaaagcga agaaagaagg cgtctcaaca ggcagctaca tcaaatcaaa tgaaaagaat 1325641 gacaataaag atataaaaga tgactccagc aaaccatccg gggaagagga tcaaaagagt 1325701 gatgaaaatg aggatgaaaa caccgatcaa actgacaccc aggacagcaa gcaaggagat 1325761 aatgaacagc tgaatgatgc ggattccgga gaccagaaag aagagaaagc ggatgaccag 1325821 attgatgata gtgacaaaga taaaaaaata aaggaatcag atgaaaacac aaataccgaa 1325881 aaagatgggg accatgagca aaccccaata caagatcctc aagataaagg aaatgaaaat 1325941 aacggcgctg acaagggcca aagccaatat cacagggact ggaacaatgg tgaacaaggc 1326001 aagaaccgtt cttcgtccag aagggataac gcttcagacc gacgtaatcc aaacggctac 1326061 agcagtgata atcattcagc taaaaatgaa gattcgccga gtgcccccgg cgaataaaga 1326121 cctgaattta tttagttgtg ccatttaatt gtgattgtgc ttgctgtacc agccgctttg 1326181 tcatttctcc gcctacagag ccgttagcgc gtgcgactgt atcagaacca aggttcacac 1326241 cgaattcttg agccacttcg agtttaaatt ggtctagtgc ctgctccacc cctggaacaa 1326301 cgagtttatt tctgctcgcc atctttttca tctccttttt cgataaagaa attcttaacg 1326361 cgtatttagt ttgaaatata cggggtttat ttatgctggc aattgttgtg gagaaaaata 1326421 aaaccccggc ctctgagccg gggtggcgca gactatagaa tgtctgctgt cattttatgt 1326481 gcggttgcct gaatatggaa tgtcaaaatg gagaggactg taatggcgat aatctgtctg 1326541 attttaagcc attggctgtc attcagttct tcaaaacggt gacggagacg ctctgtctcc 1326601 tgttcggcga tctcctgcag atttgattct ttcatagaag gagtatcttg gtgatggatg 1326661 gcatcaagca catatgcgca gctttcataa taagcaatcg ggctgatgac atcatcagat 1326721 ctgtctgaga ttgtgttaaa ggccactttt aaaatagccc gtatgtgttc aaagtcataa 1326781 atggatttta aatcacgtac aattaaaaga ataactgcct gttcaattga gtattttttg 1326841 cccagctcag ggtgtccgat cagatctttg atatcacgct ttacccagtt ttgaatcgcg 1326901 gttgacttta acgaagtcag ctcgcataag ttgccaagct ctacgatttc atttgtagac 1326961 agaccgtatt cttttttctg tttttttcgt tcgtatcttg taagaaattc aggaatttct 1327021 agatgattgg ctgctttttc tgctgacatg ttcgctgatt ggacgagaat gtcgagcggg 1327081 ctatgttctc cttgtccttt tagggaatag agcagccgca ccatatcggt tcgagagagt 1327141 ttaaaaatgt tcattgttca cctctttaaa caatttgacg cggatatagg tctatgtata 1327201 agttcaaaat tcaagcgtca gcaaattaca ttaacatcat acgtcgaatt ccttgcattt 1327261 tcaaatggat gttttataat ttaaatatac gggttctttt gaacttaaaa taacggaggt 1327321 tgttatggcg aaaagaattt ttctgtttat tctaacgaat attttggtgc ttacaacaat 1327381 cgggatcgtt ttgtctgttt taagctctgt tacaggagtc gggacgtact ttacagctga 1327441 tggcggtatc gatccaatgg cgcttcttgt gttcagttta gtcgttggat ttgtcggttc 1327501 ctttacgtct cttgcgatat ccagatggat ggcaaagacg atgatgggcg tcagagtgct 1327561 gaatccgaaa aaacactcgc tcagctatga ggaacagcaa ttggttgatc gtgttcacag 1327621 attaagccgc tctgccggtt taacgaaaat gccggaagtc gggatttacc gttcacctga 1327681 agtaaacgcg tttgcgactg gaccgtcaaa acgccgttca cttgtcgcag tatcgtcagg 1327741 gctgctggag cagatggatg acgcagcagt tgaaggtgtg cttgcccacg aggtcgcgca 1327801 tatcacaaat ggtgatatgg taacaatgac gcttttacaa ggtatcgtta atacctttgt 1327861 cgtcttttta tcgcgtatcg ccgcttggat agcaagccgt tttgtcaaag aagatctagc 1327921 gccgatcgtt cattttattg caatgattat ttttcagatt gtcttttcga tacttggcag 1327981 cctggttgtg tttgcgtatt cacgccatcg tgaattccat gctgacaggg gaggagcgga 1328041 tcttgccggc aaggacaaga tgattcatgc gctgcggacg cttaaaagct attcttcccg 1328101 gattttggaa gacgatcaga cagctgtcca aacgttaaag attaatggca agaagcgctc 1328161 ttcacttttc tctactcatc ctgatttaga tgagcgaatc agacggctgg aagctaaata 1328221 atacaaacac attgttcctc tgagagaatt ctcagaggtt ttttatttta tccattgact 1328281 aaaatcataa aaaaataagc aagttaagaa aatgtttcgt aaaagccttt aaaaatggac 1328341 ctaatatctt tagaataatt accgtactta aaaagagagg cagaaggatt ttacatgaga 1328401 ttaaagtttg gaaaattgat acaggccttg tcaccggccc agctgatcgc attatattat 1328461 tttcttgcag ttactgtggc cgttatattg ctgagtttgc cggcggccca taaaccgggg 1328521 gcggattgga cgtttattga tgcgcttttt acagctgtca gttcagtcag tgtaacgggg 1328581 ctgacagttg ttgatacagc tgatacattc agcacaatag ggatttttat attagcattt 1328641 gttctgcaat ttggcggaat cggaattatg acgctcggaa cgttcatttg gctgatcatg 1328701 ggaaaacgaa tcgggctgaa agaacggaag ctgattatgg ttgatcaaaa ccaatcccag 1328761 ttttcaggaa ttgtcaatct gatgaagcag gtactgtttc tgatcttgtg gattgaattt 1328821 tttggcgggc tgatactcgg cacatatttc ttaacctact atgactccta tcaggaagcc 1328881 tatttacacg gattttttgc cagtatcagt gcaacgacaa acggcggatt tgatattacc 1328941 ggtaattcga tgattccatt tcgccacgat tactttgtgc agtttattac aatgctttta 1329001 attatatttg gagcgattgg atttcccgtg cttgttgaag taaaggattt cctgttttca 1329061 aagcatcggc gttatccatt tacgcttttt acaaagatca cgacgattac gttcggctca 1329121 cttgtcttgt ttggagccat tggcatcttt gccctggaag caaaccatgc gttcgcagga 1329181 aaatcatggc atgatatttt gtttttgtcc ctgtttcaat caacggcaac ccgaagcggg 1329241 gggctggcaa caatcgatat cagccaatta tcagattcca cactcttttt tatttgtgcg 1329301 ctgatgttta ttggagcgtc gccaagctca gtcgggggag gcataaggac aacgactttt 1329361 gctttgaacc ttcttgcgct gtttcatttt gcccgcggca ataaggccgt aaaggtattc 1329421 aaacgggagc ttcaccctgc tgacttgatg aagtcgcttg ttgtcacgat gatggcgatc 1329481 ctgctcgttt ttggcgcgac actcattctg accattacag aaaaacattc cctgctggag 1329541 cttttgtttg aagtgtgctc ggcattcggt acaaccggcc tatcgcttgg aattacggca 1329601 gatttgagca gtgttggaaa atgcgtcatt atgattgtca tgtttatcgg gcgaatcggc 1329661 atcttgacct tcctgtatct gatcggaaga aaggaaattg aagcgaatta tcactatccg 1329721 aaggaaagag tgattatcgg ataggcaaaa caccgcatat tttgcggtgt tttttgatta 1329781 ccaaaaaaaa gatgtgtgcc tcctgttcag ttggagaacc taactccgac aggtgcaatt 1329841 tacgctcctg catcttaaaa tgtctgaaaa ttggcgagga ggattcgtat gaagcgtaaa 1329901 gctgaagtga atgaagccat taaaaataac aatacaccta ccgagagcat ggaccccaat 1329961 tcatataaga cacaatatca tgacgacccc aattttagag gggcaaaccg caattccaaa 1330021 cagggccagc agggaggcat gtaattgtga agaaaaaccg tcatagcaga gacatgcaaa 1330081 atcataaaaa gcctatgaat aaaaaggtgc tggaggaaga attctcaagt gaactcgggg 1330141 attacaatgc cggaaagatc atcgaaacgc tggaagtcac caagcctgaa aagaaaaaag 1330201 aaaaaaacaa aaaacaacaa taaaaaagac ctcttaggcg gcgtcccgct taagaggtgc 1330261 tttttctatt ttaaataagc atttttgccc gttcctctga caaattgcaa taagcttgtc 1330321 atcctcagct caatgaatgg ctgagcgact gtcttaacaa agttgctgga gaggactgat 1330381 gtcagggctg ctgttaaaag caagaggatc actaagcttt gatagtcagt aagccaatcc 1330441 tcaagcccga cctgccgtaa tgtcttaata ataaacccgt gaagcagata cacgtaaaat 1330501 gtccgggttc cccatttggt aaagaaatac cgtttttgcg gaacgagcgc taaaaagctg 1330561 aaggttgccc caaaggcgag tacataccag ccgattcggg atagtccgct taccagggta 1330621 acgtctccaa atgaagaata cggttttgaa ccaaacagaa aagaatagtc aaaatcgatg 1330681 ccccagcaga tgacgaatac tgcggcaagc actccgagcg caatttgttt gccgcgtttt 1330741 gatctcaata aatcaaaatg atgtttattt aaataaaaac cgacaaggaa catcggtaag 1330801 aatacgaatg tccgtgacaa gctcagcgtg ctgctgacaa agtccagata accgatcagc 1330861 acggcgattc cgcagctgac aaacagcgcc cactgctttg aaagctttga aaaaggatat 1330921 aggagcaggt tccaaaagaa taagcttaca agaaaccata acgaccattg cggatcaatc 1330981 gggttcacat ttgccatgct ttcatcttgc ataatgtaat aaaagacgga ataaataatt 1331041 tggaaaatca aatacggaat aatcagcttg accgccagct tttttacata tcccgcccgt 1331101 ttaaagcctt tcgcgaaata accggataca agaataaatg caggcatatg gaatgtgtaa 1331161 atgaacttgt agaggtagag cataaaatga ttatcattaa taaaggaacg aaggatatga 1331221 ccgaatacaa caaggaatat caataaaaat tttgcgttat cgaaataact gtcccgcgat 1331281 ttactcatag catcaccttc tctttcatca gtcactaaga gattattccc tgctggtaca 1331341 tattttaaaa taaaagatga aaaaggaatc taaaaaaatg ctgattgtta ggtcgatgta 1331401 aagtgacggt aaggatcgta gaaaatgtct tcgtaatgta atgacgctga aattttctga 1331461 aatttatagg gcaaatgaag gaagttcccg cattttgtag aaatattgag ggataggttt 1331521 tgaagaagga gtgtacatgc atggaaactc ttggtgtcca gacaaactcg gagctgcgag 1331581 aggaactgaa tcgcctcaaa gaagaaaacg cgcgactgaa aaaggaattg aatcagcatc 1331641 aagtgattgt caacaatacg ctcgatgcta tttttatttg tgataacgaa atgcggattg 1331701 ttcaggcaaa tgaagcaaca gaaaggatgc ttcaagttga ctcggaagat ttgaaaaagc 1331761 gttctgtttt ggattttttg ttttcaatcc caaaggatga actgaatctt tccgtaaaga 1331821 agttttttaa aaaaggcttt ctgtggaagg aggttccgat caggcttgat tgcggggcaa 1331881 caaaatacat agagtttctg gccaaaagag gtattggtga ggatttcttt tttgttgtca 1331941 tgagggacat atcttctaag aagattctgg agcgggaatt ctctatgaat gaacagcttt 1332001 ttaaggactt gtttgacaga gcagttgacg gaatcgtcct gtttgataaa gatggcggtt 1332061 ttattgatgc aaatttgtcc ttttgtaaaa gctttgaaat caatcataat gagctgtctc 1332121 atttatcttt gtatgagttc atagacagcg gctcacgaaa agatttcgac aatatctgga 1332181 aggcgctcaa ccgcaaggga aaagcgaagg gggagctgcc tgtcaagctt cgttcaggag 1332241 ttcaaaaact atttgaattc acgattacat caaacatcat cagcggtttt tatatgtcca 1332301 ttatgaggga tatcacagag aagcggtcta tggagctgca gctctttaaa agtgaggagc 1332361 gcttcagaga aatctttgaa aatgcaatgg acgccatcat catctggtcg aatgacggaa 1332421 gaatcgtaaa agcgaatcaa tcagcctgta aaatttttga gctgccgatg aatttgctgt 1332481 tgaaaagaaa gctgtgtgat tttctcgttg actcgcagca gaaatacagc ataacgaaga 1332541 ggaaatacgc aaaatacgga gagatcagag aagagctgct gtttcaaatg gggaacggcc 1332601 aattcaaaga gcttgaattt acttcaaaac ggacaatcct tgaaaatcag catttgacga 1332661 tcttaagaaa tgtaagcgac agaaagcgga tggaaaagga gcttcgggaa agcgagctga 1332721 aattcagaaa agtgttcaac ggatcaatgg acggcaatgt attgttcgac aatcaataca 1332781 ggatcatcga cgccaacccg ttagcaagcc atattttggg cctgtcacat gaagagatca 1332841 aacagcacag cctgttagat attatttctg cttatgaaat agaaaatttg gcatcaccgg 1332901 caaggcagat taattttgat gaaatggaca acgaaattcc atttttgctg agcagcggtg 1332961 ataacagaaa actcgaattc tcatttaaac ggaatattat tcaaaatatg aacttggcta 1333021 tctttaaaga cgtaacagag cgaaaagaat tggaggagcg cctgcgcaaa tcagataccc 1333081 ttcatgttgt cggcgaactc gcagccggta ttgctcatga aatcagaaat ccgatgactg 1333141 ctcttaaagg cttcattcag cttctgaaag ggagtgtcga gggagactac gccctttact 1333201 tcaacgtgat cacctcagaa ctaaagcgca tcgaatccat catcaccgaa ttcttgattt 1333261 tagccaagcc ccaggccatt atgtatgagg aaaaacatgt tacccaaatt atgagggaca 1333321 cgatagacct tctaaatgcg caagccaatc tcagcaatgt acaaatgcaa cttgatttaa 1333381 ttgacgacat tcccccgatt tactgtgaac cgaatcagct gaaacaggtt tttatcaata 1333441 tattaaaaaa cgccatcgaa gtgatgcctg acggcggaaa tatttttgta acgataaagg 1333501 cattggatca agatcatgtt ctaatctcct taaaagacga gggaatcgga atgacagaag 1333561 ataaattaaa gcgacttggt gaaccgtttt atacgacaaa ggaacgggga actggacttg 1333621 ggcttatggt aagctataaa attattgaag aacatcaagg cgagattatg gtagaaagtg 1333681 aagaagggaa gggcaccgtt ttccatatta cgcttcctgt cagacagaat gctgaagaaa 1333741 gaaggaatga tgaatgaact actatacgac agccgaaacg ccgctcggtg aacttatcat 1333801 tgccgaagag gaggaccgga tcactcgtct atttctcagt caggaagatt gggtggattg 1333861 gaaagaaacg gttcagaata ctgagcataa ggaaacacct aatcttgcag aagcgaaaca 1333921 acagcttcaa gaatatttcg caggcgaaag gaagacattc tccctgccgc tcagccaaaa 1333981 gggcactcct tttcagcaaa aagtgtggca agcgctggag aggattccat atggcgaatc 1334041 ccgaagctat gcggatattg ccgctgctgt cggcagtccg aaagcggtgc gcgctgtcgg 1334101 gcaggctaat aaacgtaacg acctgccgat ttttgtcccg tgccacagag tgatcggcaa 1334161 aaacagtgcg ttaacaggat acgccggaag caaaacggag atcaaagcat ttttgctaaa 1334221 catcgagcga atctcctata aagaaaaata aaacatatgg cacgttccct tttttcacgg 1334281 ccgacatatc attttattaa gttaaaaaag ttggtctgat gaaaaaggag gacaaagcaa 1334341 ttgaagccga gccgctctga gaaacttgcc gtttttgccg aactgtttgt gaaactgcat 1334401 atcttatcaa gcgctcaaaa agatgaaatc atcaatgtta acaaaaagaa acaaaaaaac 1334461 cgctgactcg gctccaaatg agcaaagtcc agcggttttt taatgcacct tttctccttt 1334521 aaacagctgt tcaatctctt cttcatagtt tccggtcata atcccttttt ctgtgatgat 1334581 tcctgaaatg agatcatgag gtgtaatgtc gaaagcggga ttaaagacag gcacattgga 1334641 tggagcggtc cgaactccgg aaatctgcct gacttcctcg ggatctcgtt cctctatcgg 1334701 gatatcagcg ccgcatttga cctttgtatc aaatgtagat aaaggtgcgg cgacaaaaaa 1334761 cggaatatca aaggcgtttg ctaaaatagc aagaccgtat gtgccgattt tatttgccgt 1334821 atcaccgttc tttgcaattc ggtcggctcc gacgataaca gcggaaattt gtttttcctt 1334881 catcgtatgg gcggccatgc tgtctgtgat cagagtgaca tcaatgcccc cctgcatcag 1334941 ctcccaagca gtaaggcgtg aaccttgcag gacaggcctt gtttcacagg cataaatgtg 1335001 taatcccaaa tctttttgtt tggccaagta aaacggagct agcgccgttc catagcggct 1335061 tgtcgcgatt gagccggcat tgcagatcgt catgatcctg tcgccttttt tgaaaagctg 1335121 cagggcgttt tggccgatca accggcacgt ttcctcatcc tcgacctgaa tctgaatggc 1335181 ttcatggaca aggtttgttt ttgcttcatt tacggaaatc gcgttttcga ccgaatgact 1335241 cagtctctca agcgcccatg acaaattaat ggcggtaggc cgtgagctgt ttaaatattg 1335301 tttgatgtct tccagtctgc ggcggaattc cgtgacattg tctgtttcaa tgtctttggc 1335361 agcaagcgcc agtccgaagg cagctgtaat gccgatcgcc ggagcgcccc ttactttgag 1335421 cgtgacaatc gcatcaaata catcctcttt cgtcgtcagc tccaaatatt ccgtctcatc 1335481 aggaagcttt tgctgattta aaatggtaat agctgtttct ttccattcaa cagaacgtgg 1335541 aacagcaaat gaatgggtca tgaatagatc attcctttac aagtaactta aataattcaa 1335601 taacatctgt tatcgttttg aattccgaac gtttttcgat aaaggctgtg ccggtttcga 1335661 gcgccaagcg ttttctgccg attcgtttat caaacggcac gatcgtatcc aggtcagcta 1335721 catgggcaag gccgatcgtg cgtcgtatca gctcacagcc cgcaaatccg attgcttctt 1335781 caaaaatatg gctgagcgta tcagtgaggt aaccgtcgat gttggcgtaa acatccagac 1335841 tgtccttctg ccaggcttca ctaaacgtct cttcaaacgt ttcccagacc tggttgacat 1335901 gttcatataa cggctctctg tcagccccgt cacggctgag tgcgttcaaa aataagttgg 1335961 cgataaattg ccctacatca aagccgatcg gtccgtaaaa agcaaactca ggatcaatca 1336021 cctttgtttc gtgctcactt gcgaaaatgc ttcctgtatg caaatcacca tgaatcaacg 1336081 tttctgcaga cgttaaaaat gactttttca gcttagcggc ttcgatttta acgctgtcat 1336141 tattccaaag cttttcgaca aaaggacgaa gctcttcttc aaaatcattt gtgtcatggt 1336201 cgaagaaagg atctgtaaaa acaagtcttt ccgtaatgtc gcatagctct ggatttgtaa 1336261 actgtttaac aagctgtttt ttcaccttag gttcaagcgc gtaatctgat gagtagaaaa 1336321 gtgtttttcc taaaaattca ccgatgtgct gcgacagatg aggatagttt tcaccctcaa 1336381 tgagtccttt tcttgcgatc ttgaggtgag agagatcctc catgacggta accgccattt 1336441 ccgtatcaga ataaaacact cttggaacca ggtgaggcac atgctcgccc tgacggatga 1336501 gagcgctgct ttcgattctt gcacggtcga ttgtcagcgg ccagctttct cccaccactt 1336561 ttgcatacgg aaccgcctgt ttaatgatca atgctctgtc atgttcttga tcataaatat 1336621 gaaaaacgta atttaagttg ccgtctccga tctcctggca tgtcagcgtg cttttgcttg 1336681 gaaataggcc aagcttcacc gccaacgcca cagcggagct ttcatttaac gtttcgtata 1336741 aaggtgtttt tgtgactccc atcatcataa cctccaatta tgtaattaat taatatgtgg 1336801 ccgtaaaaaa gcctccttct cagagagaag gaggcttaac atctatgtcc gcctctctta 1336861 tctctcagat cagatctgaa tggaattagc accgtgcctt aagagaccag cgtctcggcg 1336921 cgaaaaaaat gcgccccatt tcacaatgga attacggtcg gttgcttttg gggtcaaaag 1336981 gccaaatccc tcgcccaact ctcgataaga gaatatattc acttgtttga caattctaat 1337041 ttatcagttg atgaacatgg taacaggtaa tttagttagt tgtcaatata ttttttaata 1337101 taaatctttt ctgatatcat cgaaaacagg aatgctctcc cgaacttctg cgctttcttg 1337161 aaggtcgatt tccgctcgga ctatgccttc ttcccggccg ccttcagcaa gtacacgtcc 1337221 ccatggatca ataatcaggc tatgtcctgc aaattcatta tccggatttg aaccggtaca 1337281 attgcaggct gcgacaaagc attggttttc aatggcccgc gcaataagca ggcttttcca 1337341 atgatcaagg cggggaagag gccattccgc agaaataaac agcacgttgg cgccttttgt 1337401 cgtatgtttt ctgatccatt ccggaaaacg gatatcgtaa cagatcaatc cagagctttt 1337461 gacgccgtca agctcaaagt atccgtcttc ggaaccggct gataaataca gatgctcatc 1337521 catcagctga aaaagatggg cttttctgta ctctttaatg atttgccctt ccttatccgc 1337581 gatgtacatt gtattataaa catcagaatt cttcctgaca gcgaccgatc cggcgacaat 1337641 atgaacacca tgtttttttg ccgttttctt cagccagctc tgagcggagc ggccgtcttc 1337701 gtcagcgagt tcatcaagat tggccagatc atatccggtc gtccataatt caggcagaac 1337761 aagaacatca gcatgtttgc tttctttttc gatgaaaaat tcagcctttt ttatattttc 1337821 cgaaggtttt ccgtatgaaa tatcaaattg aagacaagat atcgtccatt tcatcttttt 1337881 aacaccccaa atttttcttt acttttttca tttaaccata tatgatgatg gactatcatt 1337941 tcaagatttt tttagaaggt gagaatagat gaaatttgaa cagtctcatg tattgaagga 1338001 attgcctaaa caattcttcg cttctctggt gcagaaagtg aaccgaaagc ttgcagaagg 1338061 acatgacgtt atcaatctgg gacagggaaa tccagatcag ccgactcctg agcatattgt 1338121 tgaggagatg aaacgagctg tcgctgatcc tgagaatcat aaatattcgt cttttcgcgg 1338181 ctcataccgt ctgaagtcag cggctgctgc attttacaaa agagaatacg gcattgatct 1338241 ggatccggaa accgaagtcg ctgtattatt cggcggaaaa gccggtctag tcgagctccc 1338301 gcaatgcttg ttgaatcccg gtgatacgat tttagttccc gatccgggtt atcctgatta 1338361 ctggtcgggt gtcacacttg caaaagcaaa gatggaaatg atgccgctcg taaaggacag 1338421 agcgtttctc cctgattaca gcagcataac cgctgaaata agggaacagg cgaaattgat 1338481 gtatttgaat tatccgaata atccgactgg agctgttgct acttccgagt tctttgaaga 1338541 taccgtgcgt tttgcggctg aaaacggaat ctgcgtcgtt cacgattttg cttacggcgc 1338601 tgtaggattt gacggctgca agcctttaag ctttttgcag actgaaggtg cgaaggatat 1338661 cggaattgaa atttacacgc tgtcaaaaac gtataatatg gcaggatggc gggttggctt 1338721 tgccgtcgga aacgcttcgg tcattgaagc gatcaatctt tatcaagacc atatgtttgt 1338781 cagtcttttc agagcgactc aggaggctgc agcagaggca ctgttagccg atcagacgtg 1338841 tgtggcagag caaaatgcca ggtatgagag caggagaaac gcttggatca cggcatgccg 1338901 ggaaatcggc tgggatgtaa cagctcccgc aggttctttt tttgcatggc tgcctgtgcc 1338961 tgaaggctat acttctgagc agttctcaga tcttttgctg gaaaaagcga atgtggcagt 1339021 tgcggctgga aacggcttcg gtgaatatgg cgagggctac gtcagagtcg gacttttaac 1339081 aagtgaagaa agacttaagg aagccgctta tcgaattggc aaactgaacc tgtttaccca 1339141 aaaaagcatt gacaagacct tataacgatg ggataattca aaataattta taaaatctat 1339201 attttcttat caagagcagg cagagggacg agcccgatga agcccggcaa ccgacttata 1339261 aagcacggtg ctaattcttg cagctagcgg ctgagagata agattcggac gagaaacgaa 1339321 acctctttag acgcgattgc agtttgaaga ggttttttga tatggatgaa aatgaaagga 1339381 gctctggcat gagtgagtta ttagcgacat atctcctgac cgaaccggga gccgatacag 1339441 agaagaaagc agaacaaatc gcaacaggat tgacagtagg ctcctggact gatctgcccc 1339501 ttgtaaaaca ggagcaaatg caaaagcaca aggggcgggt gataaaagtt gaggagagag 1339561 agggaactgc tgcatcagaa aaacaagcgg tcatcacaat tgcctatcct gaaatcaatt 1339621 tctctcagga tattccggct ttgctgacaa cagtgtttgg caagctgtcc ctggacggaa 1339681 aaatcaaatt aatcgatctt cacttctctg aagcatttaa gcgtgcactg ccgggaccga 1339741 agtttggcgt atacggcatc cggaagctgc tgggagagtt tgagagaccg ctgttaatga 1339801 gcatatttaa aggcgtaatc ggaagggacc tgagtgatat taaagaacag ctccggcagc 1339861 aggcgcttgg cggagttgac ttgattaaag acgatgaaat tttctttgag actggtctag 1339921 cgccttttga aacaagaatt gcagaaggaa agcaaatatt gaaagaaacg tatgaacaaa 1339981 ccggacataa aacgctgtat gcggtgaatt tgaccggacg tacggctgat ctgaaagaca 1340041 aagcgagacg cgccgccgaa ttgggagcgg atgcgctttt gtttaatgtc ttcgcttacg 1340101 gcttggacgt tatgcaaggc cttgcagaag atcctgaaat cccagttccg attatggcgc 1340161 atccagcagt gagcggagcg tttacgtctt ctccgtttta cggtttttct cacgctcttt 1340221 tactcggaaa attaaaccga tattgcggtg ctgacttcag cctctttccg tctccatatg 1340281 gttcggttgc gcttccaaga gcagatgcac tggcgattca tgaagaatgt gtgagagagg 1340341 atgcttttaa ccaaacattt gctgttccgt cagcaggcat tcatcccggc atggttccgc 1340401 tattaatgcg tgatttcggc atagaccaca ttattaacgc cggaggaggc gtacatggac 1340461 atccgaacgg tgcccaaggc ggggggcgag cgttcagagc tattattgat gcggtcctag 1340521 aggcccagcc gattgatgaa aaagccgaac aatgcaagga tcttaagctt gcgctagata 1340581 aatggggaaa ggctgaagcc gtatgacgac tcgaaaacct tttattattt gtgattttga 1340641 cggaacaatc acgatgaacg acaacattat aaatatcatg aaaacatttg ctcccccaga 1340701 gtggatggca ttaaaagacg gcgtactttc caaaacgctg tcaatcaagg aaggtgtcgg 1340761 gcggatgttc ggccttctgc ccagcagttt aaaagaagag attacaagtt ttgtattgga 1340821 agatgcaaaa atcagggaag gctttcggga atttgtagca tttatcaatg agcacgagat 1340881 tccgttttat gtcataagcg gtggaatgga cttttttgta tatcctttgc ttgaaggcat 1340941 tgtggagaaa gaccgcattt attgcaacca tgcttcattt gacaatgact atatccatat 1341001 tgactggcct cattcctgca agggcacatg cagcaatcaa tgcgggtgct gtaagccgtc 1341061 ggtcatccat gaactttctg aaccgaacca atatatcatc atgatcggtg attcggttac 1341121 agatgtggag gcagcaaagc tgtctgacct atgctttgca agggattatt tattaaacga 1341181 atgccgggag caaaacctca atcatcttcc gtatcaagat ttttatgaga tcagaaagga 1341241 aattgagaat gtaaaggagg tacaggaatg gctgcaaaac aagaacgctg gcgagagctc 1341301 gctgaagtaa aacgggaatt ggcagagaga gattggtttc cggcgactag cggcaatctg 1341361 tcaattaagg ttacagatga gcctttaaca tttctcgtca ctgcaagcgg aaaagataaa 1341421 cgcaaagaga cggttgaaga ttttctgctg gtcgatcaaa acggagagcc tgctgaaagc 1341481 gggcattctc tgaaaccgtc agcagaaacg cttttgcata cacatttgta caataaaacc 1341541 aatgccggat gctgcctgca tgtccatacg gtaaacaata atgtgatttc agagttatac 1341601 ggagaccaaa agaaaatcac attcaaaggc caggaaatta taaaagcact cggcttgtgg 1341661 gaagagaacg cagaagtgac cgttccgatt atagaaaatc cggcacatat cccgacgcta 1341721 gcggcactgt ttgcggaaga gatttcagaa gattcaggag ctgttctgat ccgaaatcat 1341781 ggtattacgg cttgggggaa aacagcattt gaggcaaaaa gagtgcttga agcgtatgaa 1341841 tttttgttca gctaccattt gaaattgaaa acactcgagc atcagctggt taaataaaag 1341901 gaggaattga aatggctaca attcgaattc atgatgaggc aaatacaacg attgaaaatc 1341961 aagaggaagt ggcaagcttt ctggacagtc aagaggttat ttatgagcaa tgggatatca 1342021 cgaggcttcc ggaacatctc tcagagaaat atgacctgac agaagaagaa aaacagcaaa 1342081 ttcttgatac cttcgaaact gaaattaaag atatctcaac ccgccgcggc tataaagcac 1342141 aggatgttat ttcattgtca gacagcaatc cgaaacttga tgaactgctt gaaaacttta 1342201 aaagagagca tcaccataca gacgatgagg ttcgttttat tgtaagcgga cacggtattt 1342261 ttgtcattca aggccaggac ggcacgtttt ttgatgtccg tttaaaccct ggagatttaa 1342321 tctccgtgcc tgagaatatc cgccattact tcacgcttca ggaggaccgc aaagttgtcg 1342381 cggtgagaat ttttgtcaca actgaaggct gggttcctat ttatgaaaaa gacagcgtga 1342441 atcaataagc gtgagatagc cccgttcatc gaacggggct ttttatattt attgcaaacg 1342501 ccacttttca tattgtgaca gttctttttt aatcagtgtc caaatcaaac ctaaaacagc 1342561 tgcatcgtca atgaatccaa gaccgaggat tacgtctgga atgatatcga gcggcatgac 1342621 gatatacagg attgcggcag ttaacagcaa aagtgtttta acctgtgaac gagggtagtc 1342681 gccatttcgc caatcgcgaa gcatctgaaa aaaagtagtg atgtgctgga tacatttttt 1342741 tcggtttttc ctctttaaaa tcgcttttcc gcctgccgct ccgagcatta ttgctttctt 1342801 tttcttcatt gggcatacct cctgcctggc ggcgtgttta agatattctt cacctgggta 1342861 ttgttcttct aatcctatca atatatctat tatacctgaa aaattaactt atttaatgaa 1342921 aatatgttta caaataaagt ataatctgta ataatgcaca ataacccaat caaacttgtt 1342981 tcctatttct tagcggcgag gggtgaagtg aatgggcggt tcttctgaac aagaaagatt 1343041 gttggtgtct attgatgaaa aaagaaagtt aatgatagat gccgctagaa agcagggatt 1343101 tacagggcat gacacgatca ggcacagtca ggagctggat tgtttaataa atgaatatca 1343161 tcagcttatg caagaaaacg aacattccca agggattcaa ggccttgtaa agaaattagg 1343221 cttgtggccc cgcagagatg ttatgccagc atatgatgca aataaatagc ggcctatcag 1343281 atgcatatat aaagagagag cttttcggaa gcgctctttt tttctggaaa aaattcatat 1343341 gaaagaggga actaatgaag gaactggcga ttctcattac cgaaatggtc aatcaatttc 1343401 atgatgcttt tatttcctta tgcggaatat ttggcattca tttaactgac aaagaaatgc 1343461 atttttgggt gatcggcatt tttggcatat tctttttcgg cgtcactcac gctgtgttta 1343521 catggctttc taaatggagt atgacagcct tgtcctttat ctataccgtt acagtcatca 1343581 ttgtcatcgt atttgcgatt gagattcagc aaaaggtgac ggggagaggg aatatggagt 1343641 ttttagatgc cacggaaggt ataaagggtt ttttagtatt ttttatgttt tttttgcttt 1343701 tgaaaatgct gttgcgtttc atcaaaatcc ttttttctgg aagaccagca agcaaatcga 1343761 atggcaatgc ccgatcacga agataaaaaa ccctcctgac atggtcaggg gggctatgat 1343821 gcggatacgg ggagggtgat cgtcacctct gtgcctcttc gcacttcact ttcaatatga 1343881 atagagcctc cgtacatcag cacgatccgt ttacaaacaa caaggccgag accggttcct 1343941 ttttctttag aagtaacaaa gggaaggaag atgtgatcca gcatttcctg agaaatccct 1344001 tcaccgttat ccacaacttt gattatggct tttttatcta aagctcctag ggagatcgtc 1344061 agtttgcctc cttcaggcat tgactcgagg ccattttttg ctacatttaa aatcacttgt 1344121 ttaatatgat cttttgtaca ttttacgagt aagggctgct cggttagata ctgtaattcg 1344181 acttcaacat tgtatagatt gccctcagaa taaatgatcg gcataatttc tccgataatg 1344241 tcctgaagtg agttcagctc ccatttttca gctgtcggct tgccgagaac gagaaactca 1344301 ctcactattt gattgatgcg ctttatctcc tgttcgataa tggagaagta aagctgatct 1344361 tcctcacctt tatatttctt ttgcaacagc tgaataaagc cgcttatccc ggtgaggggg 1344421 ttacggattt catgggctgt gctggcagca agcgtcccga tcagctctaa tttttgcgcc 1344481 tcgttttctg agcgctccag ctgggtctgc cgcttcagca aataatacag cacgagaata 1344541 aaaaggatat tcagcagaac aataatacat gaaagcggaa gcacaaggct tttcgacagt 1344601 tcttctattg tgaccgggtt cggatagact ttcatattcc agctgatatc atccagatat 1344661 ccgctgacag gtttctgatc ctctgcatga gaggcttgtc cgctcgcaaa aatcattttc 1344721 ccgtcttggt tcacaacttc aatataaaca tcagggctta gtaagttaat gagatttttc 1344781 aaataatcaa tttgaatagc tgcgacaaga taatctgtca cattacgttt tgagtccaaa 1344841 acaggcacac aaattgtgaa aattggctga ccagtaattc tgctcgaata actatctgaa 1344901 atgactgtct ttttagtttc ctttgctttt ataaaaaaag atctgtcggc caggtttact 1344961 ttcgttttta attcggttgt gcttgcggtg acgtctcctt tggcattgag aaaatagaga 1345021 ccggaaaatc tcggctctga atcaaaggtc ttttccaaaa ttgattgcat tttctttata 1345081 tcaaccggtc tgtcgatggc gatggacaag gaggtcattc tcgccattgt ttctccgatt 1345141 aaataattga ttttgttgcg gtgaaggttt agcaggacac ttgcttcttg tttatgttct 1345201 gcagctattg tatctttttc tttttcatat acgaaaaagc tgatgacgat tgccggaatc 1345261 acgaccagta tgatataaag tttgactctc ccgcaggcgc cttttagtat tttcaatttg 1345321 catcgctcca acatacacct gattagaggt attatatcat tgtttcttct tctttaataa 1345381 gaaaaaataa ccaaaaaaat tagaaaaaga tgttggcaag cttacatttt aaaaaagaag 1345441 agaaatattg gaaagatttt tattgacatt ttggtctttg tttattaatg tttctctgta 1345501 acggtttcta aaaggatgat tgagacatga cagaaaaatc actgaagtta tttatcgtgc 1345561 tgtcgcgcgc gtatcggtct attaacgatc atatgaataa gcatattcat aagcatgggc 1345621 tgaatccgac tgaatttgct gtgctagagc ttttgtacca taaaggcgat cagccgctgc 1345681 agcagatagg agataaaatt ctcttggcta gcgggagcat cacatacgtt gtagataagc 1345741 tggagcaaaa agaacttctc attcggaaag cgtctcctac agacagacga gtgacatttg 1345801 cgcaaattac tgaaaaaggc atcggtcttt tgaacgatat tttccctgat cacgctgctg 1345861 aaattgatga aatgatcagc gtattaagcg aagaagaggt agagatgtgc accgaaatgt 1345921 taaaaagagt aggattaaac gcaaaacagt ttcataataa gtaaaaaaag gaagcctgat 1345981 atgtcacaag gcttcctttt ttgctatttt tcatttgttt ccgctgcgcc tctcggcaaa 1346041 atgagaactt caacccgccg gtttttgctt cggccttccg cagttttatt ggaagccacc 1346101 ggtttatact cgccataacc cttggcgctg aacacttttg catcgagctt ggggttttca 1346161 atcaggagcc ccataaagtt taccgctctc atgacgctta aatgccagtt tgattggaat 1346221 tcagaatttt taattggcat attatcagta tgtccgctga taatgatatt tcttggcggg 1346281 ttaatcacaa gaagatttga aatctctttt gcaagcggca catcttcctt acggatggtc 1346341 gcttttccag aatcgaagaa gatgctgtct ttaatcgtaa tcagaaggcc ttcactagtc 1346401 atcttcgtct ccagctgatg ttccagcttt ttatctttga tgaacttttc cacctggctc 1346461 ttcacatttt caagttcttc ttgatcagct gctttttctt tttctttctt gtttttctct 1346521 ttctcttctt tttccttttt cacttcatcg atgccgtctg actcgttttc aggaggagtg 1346581 acactggagt agtccagtac accggttccg cctgtaaaaa cttcattaaa tgattttgag 1346641 agcatttgaa acttagctgc gtcaatcgag ctgctcgcgt acagcacaat aaacaatgcc 1346701 aggagaagag taaggatgtc ggcgtaagga acgagccatg attcatcaac gtgctcgtcc 1346761 tcatgcttct tcttcttttt tctcgccatt ttgcgcctct ccttgttctg caaatttcaa 1346821 gcggtccttc gcaggaagat acattaaaag cttttgttcg atgactttcg gtgcttgtcc 1346881 ttctaaaacg gataaaacac cttcaatcat gacctcacgc agttttactt cctgttttga 1346941 ttttcgtttt aatttatttg cgaaaggatg ccataacaca taccctgtaa agataccgag 1347001 aagtgtggca acaaaggcag cactgatggc gtgtccaagc tcatctgtgt tatccatatg 1347061 agagagagcg gcaatcagcc cgattacagc gccgagtact ccaagtgtcg gagcgtacgt 1347121 tcctgcttgt gtaaaaatag cggctcctgc ttggtgcctg tcctccattg cttcgacttc 1347181 ctctgtcata atatctctta taaattccgc gctttgcccg tcaacagcca tgctgagccc 1347241 gtttttcaag aaagcatcat ctacatcctc aatgcttgct tctaaagcaa gcagaccttc 1347301 gcggcgtgca agctgagccc attcagagaa cataggaatg agttcctcta ttgtgagctg 1347361 tttattttcc ttaaataaca ctcgaaacag cgtaggcact tttttaattt cttttgttgg 1347421 gaacgcaata acgactgctg agattgtccc ggcgataata attaaaatgg cagcggggtt 1347481 tgcaagggcg ctgaaactga cgcctttcag aaccatcccg acgctcaatg ccacaaaagc 1347541 aagaataata ccgattaacg aagttttatc catagttttc accaaatcct tttttactag 1347601 cttgtctatg gttaatatcg gttttggtgc ccggaacttt agggacattg tgaatttgtt 1347661 catgaaatat tcaaggaaga ggcatagaag ggagaaataa acaaaaacgg gctctccaaa 1347721 attgaaaagc ccgggggtct actgaaatta gcagcttgct tgcaagctgt ccttcagatg 1347781 gtattcatat aatagtagaa atacatattc actgtatata aacatgttcc atccctcctt 1347841 aaaaaagtgt aaaggatgaa gggaagtagc gcttcaggag aagggacggt aatttctaag 1347901 tcaagagtat gaaagtataa aaaaaagcgg cttcctaaaa ggaaaccgct gattgttatt 1347961 ttgctcgcac tttgatttta tcatcttcta aaatcacgtg aaaacttgtg atctcgccat 1348021 tatcaagcag cagatcggtc atttcatcct caacccattc ttggatggtt cttctaagcg 1348081 gacgtgcacc gaatgaaggg tggtagccca gctcagcgat tttttctttc gcttcatctg 1348141 tcacattcaa gctaatgccc cgttccgcca atgtttcttc aagttctcca agaagaaggc 1348201 tgacgatttt gacaagatgt tctttttcca atgagcggaa ctcaataatg ctgtcaaaac 1348261 ggttgaggaa ctcaggttta aagaacatgc tcagtgaatc aattaatgtt tgttcttcga 1348321 tgacactgtc atctgattgg aaaccgactt tcgtttgttt ctcaccagca cccgcattac 1348381 ttgtcatgat gatcacagtg tctttgaagc ttacagttct gccttggctg tctgtcagac 1348441 ggccatcttc cataatttgc aggaacatat gctgaacgtc tgggtgtgct ttttcaatct 1348501 catccagcaa cacaatgctg taaggattgc ggcgcacctt ctcagttaat tgtccagctt 1348561 cctcatggcc gacatatcca ggcggtgaac cgataatttt agatacggcg tgtttctcca 1348621 tgtattcgct catatcgagt cggataatag cgtcttttgt gccgaataat tcatctgcca 1348681 gtgttttaga aagctctgtt ttccctacgc cggtaggacc gacgaagagg aaggagccga 1348741 ctggtctgtt tttggatttt aatccggcgc ggcttcgtct taccgctttt gccacttttt 1348801 gaacagcggc ttcttgtccg atcacgcgtt catgaagttt tgcttcgagt tctttcattt 1348861 tcgtttgttc gtctgcctgc agtttgccga cagggatgcc tgttttttgt tcaacaattt 1348921 cctgaatgtg ctcagcttcc acagtgacag cggtatgagc ggaggagctg ttcagttttt 1348981 tctccaatgc gagttcttca tcacggagtt ttgccgccag ttcgtaattt tcttcttcca 1349041 gggcttttgt tttttcggct tcaattgcag ttaagcgttc agcggcatcc tcatcattca 1349101 gttcatcaat taacaggttg gcttttgaac ctgcttcatc taataaatca attgctttat 1349161 ccggcaggtg tctgtcctga atgtagcggg atgataaagt gacacatgct ttgattgctt 1349221 catcactgaa tgttacgcca tggtacgcct cgtatttgtc tttaatccct tgcagaatga 1349281 ggatagcctg ttcaattgaa ggctcctgca ccatgacagg ctgaaaacgt ctttccagcg 1349341 cggcatcttt ttcgatttga cgatattctt tcagtgttgt cgcgccaatg acttgcagtt 1349401 cgcctctggc tagggccggt ttgagaatgt tgccggcgtc cattgatcct tctgcagagc 1349461 ctgcgccgac gagaaggtga atttcatcaa tgaacagaat gacatttttt cgttccttca 1349521 gctcagtgat cagctgtttc attctctcct caaattggcc tctgatccct gtgtttgcaa 1349581 caagagatgc aacatcaagc aagtatagct ctttgttttt tagtttgttt ggaacatcac 1349641 cttcagcaat ttttaaagcg agcccttcag cgatggcagt tttccctaca cccggctcac 1349701 caataagaac cggattgttt ttgtttcggc ggtttagaat ttcgatcact cgcgccactt 1349761 catcatcacg gccgatgacg ggatcaatga gaccggcttt tgcaccgttt gtaatatttt 1349821 gagccagctc atcaagcaac cctttttttt cgctttgttt tgctgcgctc tgttctttcg 1349881 gctggaatgc ctgttcaaac ggaaatccga aagattgagg acccatactc attgaaggtt 1349941 tacgggtcag ttcgttatag caagtttcac aaagaaccat ctgtttatga acggaattta 1350001 tttgcatgtt aaggcgaatc gtcgcctcgt tttgatgaca atgttgacaa cgcatttgcc 1350061 aaaacctcct taataatttg atcatctttg accaatgaaa gtgaataaaa aggtctattg 1350121 ggtttgacct tctttgacta ttagtatacg gcaaacttaa cggcattcaa accaatatgc 1350181 tcaaagcaga ctgaatattt gactatcttt gaccaattga tttttaaaaa aggccggttt 1350241 gtttgaccaa ctttgattaa tagtatactc tgactatctt tgactttcaa gtcttatgca 1350301 caaaaatttt tgatttgtta caaagtaaaa catgttttct tcgtcttttc aaggaacttg 1350361 tctcataggt tataaaaagg catatatgga caaaactgcg gttcgttcgg agggaagaaa 1350421 tggaacaatc aaaagggtct gcaagtcagc ttgcttttgt gtatgtcggc acagtagtcg 1350481 gagctggatt tgcgactggg agggaaattg ttgagttttt tctgaagttc ggctggttcg 1350541 gttttttcgg cattctcgtc agcggcggaa tgtttacgtt actgggggcc aagctgatga 1350601 tcatttcaaa gcgaatcaat gccaagtcat atcaagaaat gaacatattt ttgttcgggg 1350661 cgacggctgg gcggattatc aatgtattta tgctgtttgt tctccttgga gttacatctg 1350721 ttatgctttc aggggcaggg gcgctttttg aggaacagct ggggatgtcc gctcagattg 1350781 ggatgctcat tacaatcggt ctgagtttaa ttgtgatgac tagaggagta aaaggcattt 1350841 tcggtgtcaa tgtgtttgtt gttcctcttt taatcatctt ttcaatgatt gtggtggccg 1350901 actcttttat attcagcgaa tcacgaaacg cagctcagtg ggtctggccg catcgctggg 1350961 attggctgtt atcagcagtt tcttacgggg ctttaaattt atcgcttgcc caagctgttt 1351021 tggttccgct ggcgaatgaa atgtcatcgg agaaagtgat aaaaaaaggc gctttaatcg 1351081 gaggcacgat gctgacgatt gtgctgtccg cgagttttct gtctttgtcg actcttccgg 1351141 atgtattttt gtatgatata ccgatggcgc aagtggttta tctctttgca cgatctgtcc 1351201 atttgattta tttactcatt attttcggag aagtgttcac atcagttatc ggtaatctat 1351261 atggattaga aaaacaagtg caaagctttc ttccagtgaa aagcaaatat atctttgcag 1351321 ccattatgat cacggcttat attacgagcc aaatagggta cggcaggctt atttcaacga 1351381 tttatccctt gtttggctat gtgagcctgg ccttcatagg cgctttgctt tgcaaaaaag 1351441 ctcctcggcg gcgcagttta taaatatata taatgaaacg aaccgtcact atagagcgat 1351501 aattgatcta ggaaccgggg actgactttt ttattgtcaa gaaaaacatc attatggtaa 1351561 gatagcagaa gtgaaaaaat tgaagaaaat ccgtgcgata tgcgggagag gttctagcta 1351621 caccctctat aaaaaactaa ggacgagctg tatccttgga tacggccttt tttatgtttt 1351681 tctagagcac cttccgaaaa aaggtgtttt tttgcgtgaa ttagctgtag cgatgtctct 1351741 cgccggcgtt tttattgcgg agaaggagag gaatcatgaa aaaagaaaaa gcaattgtcg 1351801 tatttagcgg cggtcaagac agcacaacat gcttactgtg ggccttaaaa gaattcgaag 1351861 aagtcgaaac ggtgactttt cattataatc agcgacattc gcaggaagtt gaagtggcaa 1351921 aatccattgc ggaaaagctt ggtgtgaaaa atcatttgct tgatatgtca cttttaaatc 1351981 agcttgcacc gaatgccctg actagaaatg atattgagat agaagtaaaa gacggcgaac 1352041 tgccatccac attcgttcca ggccgcaatt tggtattctt atcctttgcg tctatcctgg 1352101 cttaccaaat tggcgcgcgc cacattatta caggagtttg cgagacagac ttcagtggtt 1352161 atcctgactg ccgtgacgaa ttcgtgaaat cttgcaatgt cacggtaaat ctggcaatgg 1352221 agaagccgtt tgtgatccac acgcctctca tgtggctcaa taaggcggaa acgtggaagc 1352281 ttgcagatga gcttggcgcg ctggattttg tgaaaaacaa cacgctgaca tgctataacg 1352341 gcatcatcgc agacggctgc ggcgaatgtc cggcatgtca ccttcgttca aaaggttatg 1352401 aagaatatat ggtgatgaaa ggagagcgtg cataaattgt tatctcaaat ttatccgcag 1352461 gcccagcatc cttattcgtt tgaactgaat aaggacatgc atatctcagc cgctcatttt 1352521 atccctcggg aaagtgcggg agcgtgcagc agggttcacg ggcatacgta taccgtaaat 1352581 ataaccgttg ccggcgacga acttgacgat tcaggctttc ttgtcaattt cagcgtactc 1352641 aaaaaactgg tgcacggaaa ctatgatcac acgctattaa atgatcatga agatttttct 1352701 caggacgacc ggtattcgct gccgacaact gaagtcgtgg cgaaaacgat ttatgacaac 1352761 gtacaggctt atttagacac tttggagaat aagccgacct gtgtacaggt gtttgtccgt 1352821 gaaacaccga caagctactg tgtctaccgt ccgaaaaagg gtggtttgaa tggctaaagg 1352881 aattcctgta ttagaaattt tcggcccgac gattcaagga gaaggcatgg tgatcggaca 1352941 gaaaacgatg ttcgtccgga cagccggctg cgattattcc tgcagctggt gtgactccgc 1353001 tttcacttgg gacgggtctg ctaaaaaaga tattcgctgg atgacggcgg aggagatttt 1353061 tgcggagctt aaggacattg ggggagatgc gttttctcat gtgacgatct caggcggcaa 1353121 cccggctctg ttaaaacagc tggatgcttt tattgaactg ctgaaggaaa ataacatccg 1353181 tgcagcgctt gaaactcaag ggaccgttta tcaggattgg tttacgctga ttgatgacct 1353241 gacaatttct ccaaaaccgc caagctcaaa aatggtaacg aactttcaaa agcttgacca 1353301 cattttaact tcacttcaag agaatgatag acagcatgct gtcagcttga aggttgtcat 1353361 ctttaatgat gaagatctgg aatttgccaa aactgtgcac aagcggtatc cgggaatccc 1353421 gttttattta caagtcggaa atgatgacgt gcatacgaca gatgatcagt cactgattgc 1353481 acatttgctt ggaaaatatg aagcgcttgt tgataaggta gctgtcgatg cggagctgaa 1353541 tctcgtcaga gtgctcccgc agctgcacac cctgttatgg ggcaacaaac gcggagtata 1353601 atagaaagga agatgaacat gacgacaaga aaagaatcag aattagaagg tgtaacattg 1353661 ctaggcaatc aaggtacaaa ttatttgttc gaatatgcac cggacgtgct ggaatccttc 1353721 cctaataaac atgtaaaccg tgattacttt gtaaaattca attgcccgga attcacatct 1353781 ttatgtccta aaacaggcca gcctgacttt gcgacaatct acatcagcta cattcctgat 1353841 gaaaaaatgg ttgaaagcaa atcattaaag ctgtatctat tcagcttcag aaaccatggt 1353901 gacttccacg aggactgcat gaatatcatc atgaacgact tgattgaatt aatggacccg 1353961 cgctacattg aagtatgggg caaattcacg ccaagaggcg gaatttccat tgatccgtac 1354021 acaaactacg gaaagcctgg cacgaagtat gagaaaatgg ccgaataccg tatgatgaac 1354081 catgatttgt atccggagac aattgataat cgttaattat tccgttgtgt gatacggagt 1354141 gtaaaaggaa gtggagtcac agtaaaatcc gaacattcag cgttaatttt cagcggaaat 1354201 gtgacctggt cacagcgaag tgtgacccgc actaagctca ataaaagtgg gaaaagtcac 1354261 acctgaaaat ggctctactc atgggaattg tattaaaaag tgtgacctga ggtgcaacct 1354321 gaactgtgac ttttatgcag tgaaaaattg atagtacaga agcagattaa ggcgtacaat 1354381 ttgtacgtct tttctttttt atccgaaaga aaaaatgcct atctagagat cataggcatt 1354441 aaatattatt atcaatatct tcatttattt tttggctaag tttctgaacc ttctctttaa 1354501 catttgaaac agctcttttt tgaatttcat caattctcct gaatatagtc gatgacactt 1354561 cttattagaa cttcactttc aaaattgaat atctcattta tttctgactg ttcttcatct 1354621 gttaggtgat ggtattgaag ttgtttagca tttacttcag cagctacatc aatcctaact 1354681 tagttgttct ggttgtacaa tttcatattc accttctgca tactcttgct ccgcataata 1354741 gcctccccat tgacagagct cctgcaagat aggtttaaga gattctccaa gttcagtgga 1354801 tgaatattca accttcggcg gtacttgatt atacatcttt ctgctcacaa gtccactggc 1354861 ttcaagctct ctaagtgttt gaatcagcat tttctgagtt atatttggga taatgcgctt 1354921 taattcactc gttctctttg gtccattcat taaaaagtat aatacaaggc ctttccattt 1354981 tccgccaata acttcctttg tcacttcaaa cccacagcta aattttttca tgtctaaagc 1355041 tctccattcc acatttatta ctttttagtt actatatcac aaaaaagtgg gtacttccga 1355101 taatgtgctt actgaaggat actatatctt gtaagttgtt cttcaagtac ttaaaggtac 1355161 tagacataaa ataaaattaa ttctaaagga gtgttaagta tgggtaaatt tgaaggtaaa 1355221 atagcgcttg taacgggtgg aacaagtggg attggtcttg ctacagcaca aaaatttgta 1355281 aacgaaggtg catatgttta tattacggga cgtagacaaa acgaacttga taaagctgtt 1355341 aaccaaattg gcaagaacgt aaccggtgtt caaggtgata tttctaagct tgaagactta 1355401 gacaaactat atgacattat aaagcaggaa aaaggtaagt tggacattct ttttgctaat 1355461 gcaggcatcg gcaacttcct tccattaggt gaaattactg aagagcaggt tgatagaacg 1355521 ttcgacatta acgttaaagg aaccatcttt actgttcaaa aagcgttatc actattcccg 1355581 gacaaagtag gttctattat tgtaacgggc tctactgctg gatcaattgg caacccagcg 1355641 tttagtgtat atggagcatc taaagcagca ttaagagcac tagttcgcaa ctggattctt 1355701 gacctaaaag gtactgaaat ccgtgtaaat gtggttagtc caggaggtat tcttacacct 1355761 gcctacgatg agctttttgg tgatgcactt gaagaggtac tggaaaatag cagaaatact 1355821 gttccagctg gaaaagttgg gacacctgaa gaagtagcaa acgctgtatc tttccttgct 1355881 tcagacgaaa gcagttactt gacgggtgtt gaattgttcg tagatggcgg gctagcacag 1355941 gtataatttc actgcgcaga gattacaaat agtccccaaa aaaggttaat ggggatttac 1356001 ttgaagaagt cgtataaaaa agtcgttttc cttaaaggac agggaattcg acttttttat 1356061 atttgaattt gattaacgtt gtaaattcgc attttcctgg ggctactact aaatgacctg 1356121 taaaaaagat tacactgtga ataaatgtac ttaaagtaac gggggctctt gacttttaat 1356181 aaaaaataat atccctgtcc ttgtattcta atacttttaa aaatatttaa aggaatcctt 1356241 atgtcctgaa taaccacata ggaaaatatg ttgtaggttg ctttcttttt ttgtggggca 1356301 tcccacacaa gctatctcgt gatctcacac ctgaacgttt tttatagact agtaccgcga 1356361 caagttatat tacatataca taccaataaa gtagacatta aaaagtgaaa gagaggatgg 1356421 aaatgtgtga aaattctttt ccttgagagt catcccatgt ggctctatgg tttaccgaat 1356481 gggtttaggg aagcaggaca taccgtaatg atttccggtc ctgtaagtcg ggaaaatata 1356541 actgaaatga tagacgaatt taaaccagat ttaatagtat ctatgggatg gacaccagag 1356601 cattcaaggg aaaagcaggc ctggattcgc aacgctacta aaaaggtgaa tatccctctc 1356661 gtttattggg caactgaaga cccgctgcac actcaaaact ttactatccc gttaattaaa 1356721 aagatgaaac cggattttgt tttcacggtc acgccttctc tgtgtaaaac ttatgaaagc 1356781 atggggatta aagcagctca cttagacttt gcatttcacg aaagtataca tcaccagatt 1356841 aaaccattag cgaaatacag ttgtgatata gcagtggtgg ctaatgctta ccctaatttt 1356901 cttgaagaac atccggaagt gttccgttcg tcctctttaa aaacgcttat tcgtcctctt 1356961 atacggaagg gtattcgcat tgatttttgg gggagaaact gggaaaaaat gagtaaatat 1357021 ataggaagag aaattccccg caattggatc catggatacc ttgattatac tgaagcatat 1357081 aaagtttaca gttcagcaaa aatcattatc ggtttgcaaa actgtgaaag ccaacttaca 1357141 caacgcacct atgagattct tggttccggg gggtttttat tgacatcgga tacaccagca 1357201 gttcgaggta aattcaaacc tggccgcgat ctcatcgttt cttcctcccc aaaagaaaca 1357261 ttggaaaagg ttaaatacta tttaaatcat gatagcgaga gaaaaaagat tcagataaac 1357321 ggtaaaaagg ctgtaaagaa tgattcctat cggcatagag ccgagagaat gcttgaggtg 1357381 ctaaaaagca gaggaatcat aagaaactta ggggaaacca ttcattatgt agatgttctc 1357441 aaagaaaaat acgtgatcca tcatgttact cccggtgaaa cattatcaat aattgccagt 1357501 aagtataatg tttccctgca gcaactcatg gagcttaatc atttcaaatc agatcaaata 1357561 tatgctggac aaatcattaa gattagagag aaactgttta gaaatattaa taacaaatta 1357621 ttctaaagga gagtaatatg aatgaagggg aaaataccta aaataagaaa tcaagcgaat 1357681 aaagtaaaaa gaacgcctcg ttatatggaa tttcccgtga catacgaagt atatcatgtg 1357741 gaatccggcg atacattatg gacgattgcc aaatcctttg aaattccggt acaacaactt 1357801 atgaatctta ataagctttc ttcagataga atttatcctg gacaaattat aaagataaga 1357861 gaaagataat ctttgaggtt tcggaagcga atcaaattga aatgacaatc ctcatttttt 1357921 tatttgtggg gaacttgata tttttgggga tgaaggggtt atgagatgtt tcaaatgagc 1357981 tattactatt ctggattagg atgggacttt attcaacacg ttgatcaaac gaacggagta 1358041 ttaaatgttg tgtctcctga ttttttctat atcagaaaag atggatcatt acttctccgt 1358101 tcagctaatc ccgatgtgat taaagctctt catagaagaa aattaaaagt agttcctttt 1358161 ctaagcaatc attgggatca ggatttggga cgatttgcat taatgaaccg agttctttta 1358221 gctaaacaaa tttctcatgc aatagaagaa ctggatttgg atggagttaa tatcgatata 1358281 gaaaacctta cagaaaaaga tcggaatcta tttacagatt ttattagatt agtaaggaaa 1358341 agtattccta gacataaaga agtatcagtt gcagtggcgg caaatccttt tggctggacg 1358401 aagggctggc acggatcata tgattacgag tatttagcta aatatgcaga ttatcttatg 1358461 gttatggcct atgatgaaag ccgccttgct gggcctactg caagtgtagg atgggtggaa 1358521 aagtccattc aatatgttct gacccaaaaa atctctcctc aaaaactagt tttaggattg 1358581 ccattctatg gccgctgctg gatggaaggc caatctgcct ctcaagccat tcccctttac 1358641 cttgttgtta gtaaaaaggc atagcgggac aattattttt gacaccaaga gtcaatctcc 1358701 aaaagctatt tttactgtca atcacgataa aaaggggccg ttgccttcgg gaacatatac 1358761 attatggttt gaaaatgaac agtcactcag agcaaaaata aaactcgctc aaaaatataa 1358821 tctgaaaggt cttggcagct ggagtcttgg acaagaagat gcgtcagtct ggaatacagt 1358881 gtttaaaaat atataatgat ttatagttca gaacaaaatt cgaagataat tgcaatgaat 1358941 ctctaaatgg acatactgaa aggagtttat tacgagtgcg ggtaaaacag tgagggcatt 1359001 ccataggccc ttctcccaaa atgttctaca cgaggcatta cattgggctt gaaatacaca 1359061 ttcaaactta tgttatagta cgcattttac ggatgtgttg aatttattct gcttccatga 1359121 tttaatcata cacatgctac ttgatagcag ggttatcgca tttcattcag aattgttcag 1359181 gatcgatatg gaagcgcacg actaactaga actttaaaag catacactca tatacttcct 1359241 gaatggatgc tggtttatct aaaaaacatg atgagaattg attgtacgca tggtgaagca 1359301 tgacttgttg ataatcgacc atatggtttc tccttagaaa tgagggggtt tttacataaa 1359361 aaagacgagc gaatccgggg ggaattccac tcgccgcttt ctaatgaaaa gacgggatgc 1359421 tggatggcag ctcgtctgtt ttattataat ttaacgaacg tatgtttgta aaggtgtctt 1359481 ttcgaatgaa ttggttcata taaccgttaa gaacagattc attgtaaaca ttcgctaagg 1359541 tatgctaaga tgcatggact ataaaggagt gatatgaagt gaagacattg cggttaaaca 1359601 atgtaacgtt agaaatggct gcatatcaag aggagagcga gccgaagcga aaaattgcat 1359661 ttaccttaaa cgttacgagt gagacttacc atgatatcgc tgtcctgttg tatgaaaaaa 1359721 cgtttaatgt cgaggttccg gaacgcgatc ttgccttccg gggggaaatg acaaattatt 1359781 caacatcatt gaccaacctg tacgaaccag gggccgtcag cgagttctat atagaaataa 1359841 cggaaataga caaaaacgcc gattcatgat cggtgttttt tatgtaaaaa agctgccggc 1359901 cggcagcttt tgagaaagcg aatttcatat gtaaggtgtt aaattgtccg tcttgcagtt 1359961 ttttgaataa atgtggaaat aaggaggttt taataggagt ctctgatgat cttataattt 1360021 ttatgattaa caactgtcaa tgaatctaac tcaagatccc gatagttatc catgatcgtc 1360081 acatcaacga taacagaatt ctcatttact ttttcaacaa caccggttaa tccgttttta 1360141 aattcaatga cattcccaac cttagcgatt ttcacaagct tcctctcctt taaacataat 1360201 aatgcctttt gaaagtattt tgcagtattt tcattgagaa gtaaagcgat aaggagtttt 1360261 atctccctta tgaattgttc tgtcgctata aagatgatat attgattttc gtcaatagaa 1360321 agaaaagggg ggaatttttg ttgcgtcccg aagaaataac agaaatgatt gaacagctgc 1360381 gcaccggcgc cataaacgaa ctgagagtcc agaaagagca ttttcttgat ttcagggccg 1360441 tgttatctaa acaagatgat tttaaacatt tccgaggaat tgcccagcaa ggcggagatg 1360501 ttatctttca atacttagaa cagccaagaa gctgaaggtt tctcatacgt gagaagcctt 1360561 tttatcatat atgacagaac acaagccttt tattacagct gtctgtaaca ggtgtaaata 1360621 aaatgtaaag taccaaagat ggataaacat gttttaattt aacaatattt atagaatttc 1360681 agactgtttt tttgccatta agcagtgagt catcctcttt attccatcct gatacctcct 1360741 tgggagagtt ggaaaatctt tttccgtgaa aatgaatgga tctcttgtta aggttatgaa 1360801 gtgttttttg gagcacttta aggaggaaac tgtatgacaa cgaaattcac tgctctggct 1360861 gtttttcttc tttgtttcat gcctgcagcc aaaattgagc atacacaagc ttcactactg 1360921 agcgcaaaga agacaaaaca tgaagaagcg aaatggctta cacatataga tcgaaatacg 1360981 aatgaatctt tcccttcact gtctgctgat aaagacaaga aaataaaacc gattaagcta 1361041 tcagcacaca ctgaaaagaa agagaaagat aaaccggaca aaacaaatga tgagaaagaa 1361101 acatatacac agtctgaaaa agagttgctg tcccgtctcg ttcacgcaga ggccaaagga 1361161 gaatcatata aaggcaaggt cgctgtagca agcgttgtac tgaacaggac ggagaaaaaa 1361221 ggttttcctg atacgataag aggagttatt tatcagaaaa acgcctttga accggtcgca 1361281 aacgggagca ttaaccaaaa gcctgataaa gaatcgattg aagctgccga agaagcgctg 1361341 tcctcaaaaa atagagaaac agatgccata ttcttttata atccgaaaac agcgtcagat 1361401 aattggattc gttcaagaaa aatcgtagaa aaaatcggca gacacgtttt tgccgtctaa 1361461 gcatagaaga gacaatttgt ctcagctgtg ctttttttca tataaagagt aaaaataaaa 1361521 taatttttga acttgtctca tatgatgttg gtagtacaag agacaaggag agacatcatg 1361581 aatcgatttg tgaaagggat cattctttta tccattgccg cctttttcgc tgaatgcctt 1361641 gaatttgtcg tcaatatgat tttggcgcgg gagcttggcg agcatgggat ggggctttac 1361701 atgagtattt tgcccacgat ctttttaatt attgtcatcg cgagcctgga actgccgata 1361761 tccatttcta aattcattgc cgagtcaaat cctaagcttc atgaaagcat gctgaggcac 1361821 gctttcagaa tgacagccat ttttactgct ttttctactg ccgccgctag tattgcgctt 1361881 ccgtttattc cggtatttga tacataccac ccgtttatta aagggattgt catcggctta 1361941 attcctgttg tcgcctttac ttcaatcgcc aggggctact ttatgggtgt gcagaaaatg 1362001 gggaagatcg caattgccaa tgtgctgaaa aaaatcatcc agctcttgtg cttattcctc 1362061 ttttttcaat ggtactcatt tgaattggac atggctgtgc tgatttcctt gtttgttcta 1362121 gtcgtgagtg atgtggtcgt gcttgtttat ttatattcac aatttatcat ggcaaggcgg 1362181 gcgttatccg gccagcagca cattcatttg cgcggaaagg atgtaaggaa aagactgctt 1362241 gctgtttcaa ttcctacaac aggactgcgt atttttcatg cggttgtcaa tgcaattgaa 1362301 ccctttttag taaaaggagc tcttttggct gcgggcgttg ccgggacagc ggcgatcgat 1362361 caatacggaa tgctggcagg agtggctgtg acgatagggt cgttccctgc ttttattgcc 1362421 cattcgttaa tggtcgtcat gataccgagt atttcggaag cttatgcact ttctcagtat 1362481 gacatcgtgt taaaaaggct gaagcagtcg attttcatta cattaggtta cggtatacct 1362541 gccgtctggg tcatgttcca gtttgcggga cctctcacgc atttgttttt tcactctcct 1362601 gaagcgcagt attacttgca gctgttgtgg ccttactttc tctttcatct gtttgtcatg 1362661 ccgctgcagg cgtgcttaat cgggatgggt tttgtgaaag aggcttttta tcacaatgta 1362721 tggagccata tcgttgcgct aagtatgatg tatgtactgg gatcaatgga gaatctgcaa 1362781 atgctcggga ttatccttgg aatgaacact ggcatgattc ttttgacgag cctgcactat 1362841 gccacgatct gcaaagcatt gaaggtatct gtatttctta cgggagggac cagaacgccg 1362901 cgaattgaag gatgataaag gaacagcagg ggcaagctaa ttgaaaagca tgaaaggaag 1362961 attccatgtt gacgaagcgc ttgcttacta tatacattat gttattaggg ttgattgcat 1363021 ggtttccagg tgcggcacaa gctgaggaaa aacagcctgc tgttcccgct gtttttctta 1363081 tgaaaacgat agaaggggag gacatctcga ttccgaataa agggcaaaaa acaattctcc 1363141 atttttggac gtcatggtgc ccgccctgca aaaaggagct tccacagttt caatcgtttt 1363201 atgatgccca tccatccgac agtgtaaagc tggtaacggt gaatttagtg aattcggaac 1363261 aaaatcagca agtcgttgaa gactttatta aagcaaacaa gctgacgttt ccgattgtcc 1363321 ttgactcaaa aggggaattg atgaaggagt atcatatcat cacgatccca acatcatttt 1363381 tgctgaatga aaagggagaa attgaaaaaa caaaaattgg cccgatgaca gcggaacaac 1363441 tgaaggaatg gacggaagaa tagctgagag catagactct cagctttttt catatagaga 1363501 agaagtgaat aaacattaat gataattatt atcaaaaaga aattaaaata attataattg 1363561 aaattctctt cgtgcgtgct ataataaagg aagacatcaa gaaataactg acgataaagc 1363621 tgccttttgg gcagcgattt tgtttttata agagaaatga agatgattta cgttctcaat 1363681 tagagaggag aattcgatat gaatgaacaa gttatcgttc aacgcgaccc gcatgagcca 1363741 ttgaaaacag acaagaggga aaaaaactgg gcacagcacg cggagcttat tgcagcactt 1363801 gtatcaggcg ctcttatttt ggcaggctgg ctcttatccg gatatcaggt attatccata 1363861 atacttttct tgctggcttt tgtgatcggc ggatttgcta aagcgaagga aggaatcgaa 1363921 gaaacactcg aatccaaaac gctgaatgta gaacttttaa tgattttcgc tgccattggt 1363981 tccgccttga tcggatactg ggcagagggt gctattttaa tatttatttt ttccttaagc 1364041 ggagctttag aaacatacac gatgaataaa agcagcagag atttaacgtc tttaatgcag 1364101 cttgagcctg aagaagcgac attgatggtc aatggtgaaa ccaaaagagt tccggtttca 1364161 gacttgcagg ccggtgatat gattgtgatc aaacctggag aacgcgtagc ggcagacggt 1364221 atcattgaat cgggctcgac aagtcttgac gagtcggctt taacaggtga atcaatgcct 1364281 gtagaaaaaa acacaggcga cactgtattc acaggaacgg tgaatcgcaa tggctccttg 1364341 acagtccgtg tcacgaaagc aaatgaagat tcgttattca gaaaaattat caaactggtt 1364401 gaatcagcgc aaaatagtgt ttcacccgcg caggctttca tcgaacgatt tgaaaatgct 1364461 tatgtgaaag gtgtgctaat tgcggtggcg ctccttttat tcgtcccgca ctttgcgctg 1364521 ggctggagct ggagtgaaac cttctaccgc gcaatggtgt ttatggttgt cgcgtcacct 1364581 tgtgcgcttg tcgcctctat tatgccggcg gcgctgtccc tgatttcaaa tggcgcccgc 1364641 aacggtatgc ttgtgaaagg aagcgtcttt cttgaacagc tgggctcagt gcaaatgatc 1364701 gcctttgata aaaccggaac tgtaacaaaa ggccagcctg ccgtagagac gatcagaata 1364761 gcagaaggat tcagtgaagc ggaagttctt gaggctgtct atgccatcga aacgcaatca 1364821 agccatccgc tcgcccaagc cataacggcg tacgctgaaa gccgcggcgt gaatcagtcc 1364881 ggctacatat ctatagaaga aacctcaggg tttggcgtta tggcagaagt gtcgggtgcg 1364941 aaatggaagg tcggtaaagc aggttttatc ggcgaggaaa tggcagcaca atttatgaaa 1365001 caaacagcat cagatgtcat tcaaagcggt catacaattg tatttgtgaa aaaggatgat 1365061 caaatagcag gctgtatcgc actgaaggac caaatcaggc ctgaagcaaa agaggtcatg 1365121 gaagaactga accgacttgg gattaaaacg gccatgctga caggagatca cgaagacacg 1365181 gctcaagcga ttgccaagga agccggcatg acaactgtcg tggcagaatg cctgcctgac 1365241 caaaaagtga atgaaatcaa acggttaaaa gaagaattcg gaacgattgc aatggtgggt 1365301 gacggaatca atgatgcgcc ggcactcaaa gcagcggatg tcggcattgc gatgggcggc 1365361 ggaacagatg tagcacttga gaccgctgat atggtcctca tgaaaaacga tttgaaaaag 1365421 ctcgtaaaca tgtgccgctt gtctcggaaa atgaacagga tcatcaaaca aaatatcgtg 1365481 ttttctctag ctgtaatctg cctgctgatt tgtgcaaact ttttgcaggc gatggaattg 1365541 ccatttggcg tgattggtca tgagggcagc acgattttag tcatactaaa cggtttaaga 1365601 ctcctaaaat aaaaccagca gcctaatcag gctgctggct ttttatgtat caagctttcc 1365661 cttcattttt gtctttatca gatcttttca taactaggat gagagcgagg gtgcagcaaa 1365721 ggaaacccgc tgcacagcct atgatagagc tgtaataata aaagcccacc atcttcatcc 1365781 cgataaaagg agcggaaatt cccaaaaccg ttaagagcat aactgctttt cgtctgaaaa 1365841 aattcatcag caaacggaac aacccccctg cgattgaacg ttactgtcag tatacaggaa 1365901 gaggagcagg aaataaaatg cattagaaaa tgaaggcgtc gtgaaaggca aacaccggta 1365961 aaacctgtta caatggaaga cagaacaatg cattgcaaat ggcagggagg aacaagaagt 1366021 gaatagaata caacgcgtct cttcatggct gaaggaagcg gggcatactg ccgcatttat 1366081 tcatacgaaa gaaaatgttt tttacttaac cggtttttac acagagccgc atgaaagatt 1366141 aatggggtta tttatttttc aagaagagga gcctttcttt gtttgtccag gaatggaagc 1366201 aggacaggcc cgcaacgcag gctggaatca tgaaatcatt ggctatgcgg atcacgaaaa 1366261 tccgtgggag ctgatagaga aggctttgaa aaagcgaaat atcagcatac atatgcttgc 1366321 ggtagaaaag gattcaatct cgctgtcacg tgcagaacag ctgaagcatg cgacgggcgg 1366381 ggctcaattt gtttcagcag aagaaacact caatcaattt cgcctgatta aagatgacaa 1366441 tgagattcgt ttgctgaaag aggcggcaaa gcttgcagat tacggtgttg aagtcggcac 1366501 agccgctttg cgtgaaggca tcagtgaagt ggaagtgctc gctcaaattg agtatgagct 1366561 gaagaaaaaa ggaattcagg gcatgtcttt ctctacaatg gttttattcg gagaaaaatc 1366621 tggccagcct catggaaatc ctggtacagc cacgttgaag aaaggtgatt ttgttttatt 1366681 tgatctcggt gttattcttg atggctattg ctctgatatt acaagaacgt ttgcatacaa 1366741 aaccatcaat ccgaagcagg aggccattta cgagactgtg cttcaagcgg aaaaagccgc 1366801 gattgaggca agcaaacccg gtgtgagaat cggagatctg gatttaactg cccgcggaat 1366861 cattgaaaaa gcgggatatg gtgattattt tcctcaccgg cttgggcatg gactcggaat 1366921 ttcagtccat gagtatccat caatgagcca ggccaacgat acactgctgc aggaaggcat 1366981 ggtctacacg atcgaaccgg ggatttatgt gccagagatc ggcggcgtac gcattgagga 1367041 tgacgttcac gtaacaaagg acggagcagt tgctctgacc caatatccaa aggatttgat 1367101 catactgtaa tagaaataaa aaaggacttt gttctcgaca tcgtcctttt ttatctgcat 1367161 taaataaaaa aatcatcaaa tgttcgaaag ggtttaattt catgtttttg gttgagaggt 1367221 tttacagcaa gacagctgcc accgagaaca gtgagacata acccaattaa aatgaagaaa 1367281 cccatgtgat cttctccttt cagctaaaaa cacaaaaaga tatctggtac gtccatatca 1367341 tattgtatga aacgcattcc agatcaaggg gatttagaaa gaagggaatc tatggctaat 1367401 attaaagaca ttgcagagaa agccggtgtc tctgttacaa cggtttcccg agtcataaac 1367461 aatcatccat acgtcagtga agacaaacga aaaagagtgt ttgaggcaat ggaatcattg 1367521 gagtacacga gaaatattca cgctgtacat ttgtcgaaag gattttcaaa catgattggt 1367581 gttgtcttgc cgacggttaa tctgccatat tttgcagagc tgattgcagg aatagccgac 1367641 gcagccgcgg aatccggggt tcacctctct ttattccaaa caaactatga agtacaaaaa 1367701 gaaatctttg cgctgtccca attaaagcag cgccaggttg acggcctgat tttttgctca 1367761 aaggcgcttg ctgatgagaa actcatggaa tgggagggcc cgattttgct ttgccagaat 1367821 tcagataatg cccgcttccc aaccatcagc attcctcacc aagaagcatt tcggaacggc 1367881 ttggactatt taattgccaa agggcacaaa aaaatagcca tctgtttggc aagaaaaaaa 1367941 ggcatgaaca gccattttcg aatcaaagcc tacaaagagg cattggaaga gatcggcgag 1368001 gcatttcgtg aagactgggt aattgagaaa gcgattacaa tcaatgatgg gaaggcgctt 1368061 tttcataaat ggaatacgtg gaaggaaaag ccgacggcta tttttgttgc caatgaccaa 1368121 gtctcagcag ggctttttct tgaagcaaag aaccagcggg tgtcagtacc ggatgagctt 1368181 gcaatcttaa gcgttgataa ccacgaaatc agccaagcgc ttggaatcac aacgatcgat 1368241 attcagacaa gggaaatggg aaagcaggca tttgccatat tggaaaaaag aattcaagga 1368301 cagccgattg aaaggaaagt tctggattac cgtctcatcg aaagatcgac tgtttagtga 1368361 atgcattgaa aaaaggtttg acgtgcattc tgttcgttat gtacgatatg aggtattgaa 1368421 tgacaaagga gctgaggatc gtgaatgggt ccttcacagt gaaaaaggta ctgaataata 1368481 acgtattaat tgcttctcat cataaataca gcgaagtcgt tttaatcgga aaaggtattg 1368541 gtttcggaaa aaaacaagat gatgtcattg aagataaagg ctacgataaa atgttcattt 1368601 taaaagacga gaaggaacaa aagcagttta aaaagctcct tgactatgtt gatgaaaagc 1368661 tcgttgatat ttcaaacgat gtcatctatc acataagcaa taggacgaat cactcattaa 1368721 atgaacatat tcacattgcg ttgacagacc atatcgcatt tgcgatcaaa aggcagcagc 1368781 agggatttga tatgaaaaat ccatttctaa tggagactca gtcactatat cctgaggagt 1368841 accaaattgc caaagaagtc atagatatga tcaatgaaaa agcgggactc tgccttccgg 1368901 aaggggagat tggttttatc gctctgcata tccattcagc gttgacaaac cgtccgctgt 1368961 ccgaggtcaa tcagcactct cagctcatgg cgcagcttgt cgaggtgatt gaagactcat 1369021 ttcaaatgaa agtaaataag gaaagtgtca actatttgcg gctgatcagg catatcagat 1369081 ttacaataga aagaattaaa aaagaagaac cgactaaaga accagaaaaa ttaatgttgt 1369141 tattgaaaaa tgaatatccg ctatgctaca atacagcttg gaaattgatt aaaatcttgc 1369201 agcaaacatt gaagaaacca gttcatgagg cggaagcggt ttatctgacg cttcatctgt 1369261 accgattaac caataaaatt tcataaattc agtttatcct tataacgtgt tactgattcg 1369321 atcaggcatg agtgattgag ggaaaaaaac gggaagttca ttctcgttct tttgcgcacc 1369381 caattttgct catgcctttt tgttgtgtaa aagggcaaat gtaaacggtt aaactggaag 1369441 acttacgcct gtgaattcgt tgtcatgatt tttagctgta aggtcagact agtaaaaaga 1369501 ggaggtcaat tcttatgttt aaagcattat tcggcgttct tcaaaaaatt gggcgtgcgc 1369561 ttatgcttcc agttgcgatc cttccggctg cgggtatttt gcttgcgatc gggaatgcga 1369621 tgcaaaataa ggacatgatt caggtcctgc atttcttgag caatgacaat gttcagcttg 1369681 tagcaggtgt gatggaaagt gctgggcaga ttgttttcga taaccttccg cttcttttcg 1369741 cagtaggtgt agccatcggg cttgccaatg gtgatggagt tgcagggatt gcagcaatta 1369801 tcggttatct tgtaatgaat gtatccatga gtgcggttct tcttgcaaac ggaaccattc 1369861 cttcggattc agttgaaaga gccaagttct ttacggaaaa ccatcctgca tatgtaaaca 1369921 tgcttggtat acctaccttg gcgacagggg tgttcggcgg tattatcgtc ggtgtgttag 1369981 ctgcattatt gtttaacaga ttttacacaa ttgaactgcc gcaatacctt ggtttctttg 1370041 cgggtaaacg tttcgttcca attgttacgt caatttctgc actgattctg ggtcttatta 1370101 tgttagtgat ctggcctcca atccagcatg gattgaatgc cttttcaaca ggattagtgg 1370161 aagcgaatcc aacccttgct gcatttatct tcggggtgat tgaacgttcg cttatcccat 1370221 tcggattgca ccatattttc tattcaccgt tctggtatga attcttcagc tataagagtg 1370281 cagcaggaga aatcatccgc ggggatcagc gtatctttat ggcgcagatt aaagacggcg 1370341 tacagttaac ggcaggtacg ttcatgacag gtaaatatcc atttatgatg ttcggtctgc 1370401 ctgctgcggc gcttgccatt tatcatgaag caaaaccgca aaacaaaaaa ctcgttgcag 1370461 gtattatggg ttcagcggcc ttgacatctt tcttaacggg gatcacagag ccattggaat 1370521 tttctttctt attcgttgct ccagtcctgt ttgcgattca ctgtttgttt gcgggacttt 1370581 cattcatggt catgcagctg ttgaatgtta agattggtat gacattctcc ggcggtttaa 1370641 ttgactactt cctattcggt attttaccaa accggacggc atggtggctt gtcatccctg 1370701 tcggcttagg gttagcggtc atttactact ttggattccg atttgccatc cgcaaattta 1370761 atctgaaaac acctggacgc gaggatgctg cggaagaaac agcagcacct gggaaaacag 1370821 gtgaagcagg agatcttcct tatgagattc tgcaggcaat gggtgaccag gaaaacatca 1370881 aacaccttga tgcttgtatc actcgtctgc gtgtgactgt aaacgatcag aaaaaggttg 1370941 ataaagaccg tctgaaacag cttggcgctt ccggagtgct ggaagtcggc aacaacattc 1371001 aggctatttt cggaccgcgt tctgacgggt taaaaacaca aatgcaagac attattgcgg 1371061 gacgcaagcc tagacctgag ccgaaaacat ctgctcaaga ggaagtaggc cagcaggttg 1371121 aggaagtgat tgcagaaccg ctgcaaaatg aaatcggcga ggaagttttc gtttctccga 1371181 ttaccgggga aattcaccca attacggatg ttcctgacca agtcttctca gggaaaatga 1371241 tgggtgacgg ttttgcgatt ctcccttctg aaggaattgt cgtatcaccg gttcgcggaa 1371301 aaattctcaa tgtgttcccg acaaaacatg cgatcggcct gcaatccgac ggcggaagag 1371361 aaattttaat ccactttggt attgataccg tcagcctgaa gggcgaagga tttacgtctt 1371421 tcgtatcaga aggagaccgc gttgagcctg gacaaaaact tcttgaagtt gatctggatg 1371481 cagtcaaacc gaatgtacca tctctcatga caccgattgt atttacaaac cttgctgaag 1371541 gagaaacagt cagcattaaa gcaagcggtt cagtcaacag agaacaagaa gatattgtga 1371601 agattgaaaa ataagggtgt tagtacgccg tgcttgtcag atgacaagta cggttgtatg 1371661 atataatatt gtgaagtaat aaagctttaa gttaaaagga gaatgataaa aatggcacaa 1371721 aaaacattta aagtaactgc agattctgga atccatgctc gtcctgcgac agttcttgta 1371781 caaactgcta gcaaatacga cgctgacgtt aatttagaat ataacggcaa aacagttaac 1371841 cttaaatcta ttatgggtgt tatgtcttta ggtatcgcta aaggcgctga gatcacaatc 1371901 tctgcttccg gagctgacga aaacgatgct cttaacgctt tagaagaaac aatgaaaagc 1371961 gaaggactcg gcgagtaatg caagaattaa aagggattgg tgcttcagcc ggcatcgcga 1372021 ttgcaaaagc gtaccggctt gaagagccag atttaacggt tgaaaagaaa aacatctctg 1372081 attctgaagc ggaagtaagc cgttttgatg aagcgattgc acgttcaaaa gaagagctcg 1372141 aaaaaatcaa agagcacgct ttgaaagaac tgggtcagga taaagctgat attttttctg 1372201 ctcacctttt agttctcagt gaccctgagc ttctgaaccc tgtgaaagaa aaaatcagca 1372261 ctgattcagt gaacgctgaa ttcgctttaa aagaaacgtc ttctatgttc gttactatgt 1372321 ttgaatctat ggacaacgaa tatatgaaag agcgtgcggc agatatccgc gatgtaacaa 1372381 aacgcgtaac cggccacctg cttggcgtcg aaattccaaa cccaagcatg atctcagaag 1372441 aggttattat tgtagctgaa gacttaacac cgtctgacac agctcaatta aaccgtgagt 1372501 tcgtaaaagg attcactact gatatcggcg gacgcacatc tcactctgcc atcatggcac 1372561 gttctcttga gattccagca gttgttggaa cgaaagctgc tacaggcacg atccaaaacg 1372621 gcgtgactgt tatcgttgac ggtatcaatg gcgatgtcat tattgaccca tctgcggaaa 1372681 ctgtaaaaga gtatgaagaa aaacataatg cttatttggc tcaaaaagct gagtgggcga 1372741 agcttgtcaa tgaaccgact gtctcaaaag acggacatca tgtagagctt gcagcgaaca 1372801 tcggtactcc tgatgatgta aaaggtgttc ttgaaaacgg cggagaagca gttggccttt 1372861 accgtacaga attcctttac atgggaagag atcagctgcc tacagaagat gagcagtttg 1372921 atgcttacaa aacggttctt gagcgtatgg aaggaaaatc agtcgtcgtg cggacacttg 1372981 atatcggcgg agacaaagag cttccttacc tgcagcttcc taaagaaatg aacccgttcc 1373041 tgggatatag agcgattcgt ctttgccttg aagagcaaga aatcttcaga acacagcttc 1373101 gcgcgctgct tcgtgcaagt acatacggaa acttgaaaat catgttccct atgattgcga 1373161 cagttaacga attcaaagaa gcaaaagcga tccttcttga agagaaagaa aagctcgtaa 1373221 aagcgggaca ggctgtatct gacgatattg aagtcggaat gatggttgag attccgtcaa 1373281 ctgcagtcat cgctgatcag tttgctaaag aggttgattt cttcagtatc ggaacaaacg 1373341 atttgattca atacacaatg gcagctgacc gtatgaatga acgtgtatct tacctgtatc 1373401 agccatacaa cccggcaatc cttcgcttaa ttacactggt aattgaagca gcacacaaag 1373461 aaggaaaatg ggttggcatg tgcggagaaa tggcaggaga cgagattgcg attccgatcc 1373521 ttctcggctt aggcttagat gagttctcaa tgagcgcaac gtctatcctt ccggcaagaa 1373581 cacaaatcag caaattgtct aaacaagaag ctgagtcatt caaagagaaa atcttatcta 1373641 tgagcacgac agaagaagtt gtcgcgttcg taaaagaaac attcaagtaa tgtacaaaaa 1373701 ccagacggcc tccggcctgt ctggtttttt tcataagtaa gggtatagaa ggacacaata 1373761 acatggctag gagggatagt atgtcaaacc aatttaacgc aggagatact gtttatgtga 1373821 tctacagaaa tccgcacgcc gccaatgtag cccacataaa ggaagccgaa attgtgcacc 1373881 atccatacca tgaaggcgag ctttccctgt ttatttatga aacctatcat ccattcgcag 1373941 aggacgatgc tgtgtttgca agctatgaag aagctaaatc gctttacaaa gaactgtttg 1374001 atattgatcc gtatgagtaa caaggaaatc attacaactc atatcctttc cgcctagtga 1374061 gaaaagtaac gttagtaaag gaaaaggatg tggcatcatg cagaacccat ttgttccgca 1374121 gcttgtgtat atagaaccga gggcgctgga atatccgctg ggccaagaat tacaagataa 1374181 atttgagaat atgggtattg aaatcagaga aacgacatcc cacaatcagg tgcgtaatat 1374241 ccctgggaaa aatcatcttc agcaatatcg caatgcgaaa tcaactttag ttatcggtgt 1374301 ccggaaaaca ttaaagtttg attcatccaa accctcggcc gaatatgcca ttccgtttgc 1374361 aacaggctgc atggggcatt gtcattactg ctacctgcaa acaaccatgg gatcaaagcc 1374421 gtatatcaga acttatgtaa acgtcgaaga gattttagat caggcagata agtatatgaa 1374481 ggagcgcgca ccagagttca caaggttcga agcatcatgt acgtcagaca ttgtaggaat 1374541 tgatcatctg acacacacgc tgaagcgcgc cattgaacat tttggccaaa gtgatctcgg 1374601 aaagctccga tttgtaacga aatttcatca tgtcgatcac ctattagacg caaagcataa 1374661 cgggaaaacg agattcagat tcagtattaa tgccgactat gtgattaaaa actttgagcc 1374721 gggaacttca cctcttgata agcggataga agcggcagta aaagttgcaa aagcaggcta 1374781 cccgctaggc tttattgttg ctccgattta tattcatgaa ggctgggaag aaggatacag 1374841 acatctgttt gaaaagctag atgctgcttt gccgcaggac gttagacatg acattacgtt 1374901 tgaattaatt caacaccgtt ttacaaaacc ggccaaacga gtgatagaga aaaattatcc 1374961 gaagacgaag ctcgaattag atgaagaaaa gcgccgttat aaatggggcc gttacgggat 1375021 cggaaaatat atttatcaga aagatgaaga gcatgcactt cgagaggcac ttgaatccta 1375081 tattgatacc tttttcccta acgcaaaaat tgaatatttc acttaaacgg gctgttgtga 1375141 tcaacagctc gcttttttat aaaaaacatt tttccattcc atcaaaacgc cgtaattcaa 1375201 tgattcttta tcctccaaat aattgctgac tacacgaata ggtgaacgcc cgcaacggag 1375261 gagaaaggac agcacagggt cgtttttcct gccttccatc acatcttcaa cgtactgaac 1375321 agcgctgatc tcgtgtgcgt atttataata caaaggaatg cggccgccgc cgagaaggcg 1375381 ttccagtctt ttatcaacag tcagctcata catcgtattc atcagccatt ttccgattcc 1375441 aagctttcga taatgaggag aaacagaaat atccactaca tataaagtat ttccatgagg 1375501 ttcatgattt ttaatcgatc cgttgtcagt tgcttgtgcc catgtatgat caggagaatc 1375561 aggctcaaat tgtacaataa gagcagtcat ggaaccgata attctgccat tgatgagcgc 1375621 gcataaagcg ccttccggaa aggttttgat atggctggca agctggtcct ctgaccacag 1375681 caattcctgg ggaaacggag gagggaaaca ttcttcttga agagaaatca gcctctcgat 1375741 gtcagtctca gtgtagtttc taatggtcag agcctcaaat tttctgccgt catgcacata 1375801 catttgtttt agtatgatca tcactctcct tatgttgttt cattataacg aagattgaat 1375861 tttcagtaaa tatattccga ttttcttata atttattttt tgattattca tttttcaaac 1375921 gaaagggccg atatagaaat taggagggga ttggtttgtt taaaaaactt cacatgaaga 1375981 ttgctgtttt tgtttcgatt atgttaatca tcacagttgt tctcttaatg ctgtcttctt 1376041 atttgacgct aaaaccgatg attacagagg atgggaaaaa tacaactcaa aacgtgacgc 1376101 agtcacttga acaaaatatt gaattgcaat taaagagtta tgccatttcg ttatcaagat 1376161 tggctaatgg ggaattaacg catacatttg taacgaaacc aagtaaagaa gcttctcggc 1376221 tgtttcacga tgacattaag caaatcaaag acaacgatga ttatgttgcg atggcttaca 1376281 taggcaccgc aaaaaaagaa atgtttacat atccaaaagc ggatttcgct gaggattacg 1376341 atccaacatc aagaccatgg tataagcttg cagctgaaac cccggatcaa gttgtttgga 1376401 cggaacctta taaagatgtc gtgacaggag acatgattgt tactgcatcg aaagcgatct 1376461 tagacaggca aaaagtgata ggggttgcca gctatgactt gaaactctct gctatccaga 1376521 gtatggtcaa taaacaaaag gtgccttaca aaggatttgc ctttttagct gatgcgagcg 1376581 gcaatctttt agcccatccg tcaaatcaag gaaaaaatat atcaaaggat caaacactgc 1376641 aaaccatcgc atccgagaaa aaagggatac aagatgtgaa tgggaaaatg gttgtgtacc 1376701 aaacgattgg cgagacaggc tggaaggtcg gaacgcaatt tgataccgat caattaatgt 1376761 ggatttcaga taaaatgaat cgggccaatc tttggatatc attgattgcg cttatcataa 1376821 caattattct cagctacttc ctggccaaaa cgataaccgg tccgatacag cagctgatcg 1376881 taaaaacgaa agctgtttcc gcaggcgatt taacagtgcg cgcggaatca aaatctaagg 1376941 atgaagtcgg tattttaaca agagatttca atctgatggt tgaaaatatg aaggaaatgg 1377001 ttgagcaagt gagactctct tcagggaaag tatctgacac ctctgaacaa ctaacggctg 1377061 tggctgccga aactaatgaa acaagcggac aaattgcaaa agcgattgaa gaagtagccg 1377121 caggggcatc ggaacaggct tctgaagttg aaaccattaa tgaaaaatcg gaaagcctgt 1377181 caacgaaaat caggcaaatc gctgaggagg caggcggaat taaagaacgc tcaaaatcgt 1377241 ccgaggatgc aagctataaa ggacttgacg cgctcggcca gctgctgatg aaatcaaacg 1377301 aagccaatat ggaaacgaaa aaggttgaaa cgatgctgct ggatttggaa aatcaaacta 1377361 agaatattga agaagtcgtt acagcgattt caaacatatc tgatcaaacc aacttgcttg 1377421 ccttaaatgc cagtattgag gcagccagag ccggagaaag cgggcgcggt tttgccgtcg 1377481 tagccgatga agtgcggaag ttagctgagc aatcagccct ttctacaaag catatcagcg 1377541 agactgtgaa gcttatccag cttgagacaa aagaggcctc tcacgcgatg gttgaggcaa 1377601 gcagaatgaa tgatgaacaa aacagtgcaa ttcacgaaac tggagaggta ttaaatacga 1377661 taactgcaga aatgcagtca ctggtacaag gtattgatca catttacgcg gaaattcaaa 1377721 gaatgagtga agaacagctt gcgatttctg aagccattca aagcatttca gccatatcac 1377781 aggaatcagc tgccgcagca gaggaagtga acgcatcaac cgatgaacag cttgtcaccc 1377841 ttgataaagt caaacactca acggaaacac taaaacatgc aagccaagag cttatgaaca 1377901 caattgcaaa attcacattg taatccaatt acatccccaa acatcatttg ttttggggat 1377961 tttttatttt ataagatgaa tagatatggt agtctagaaa atgaaggaaa aatgataaat 1378021 tttaactaaa atctaaacga aacatctggg aggaatgacc ttgaaaaaaa caattggttt 1378081 tatcggtctt ggagtaatgg gaaaaagcat ggcatcacat attctcaatg acggccatcc 1378141 tgtattggtg tacacccgga caaaagaaaa agcagaaagc atacttcaaa aaggcgcgat 1378201 ctggaaagat acggtcaaag atctttcgaa agaagcggat gttatcatca caatggtcgg 1378261 ctatcccagt gatgttgaag aagtgtattt cggaagcaat ggaattattg aaaacgcaaa 1378321 agaaggtgca tatcttattg atatgacgac atctaagcct tcgcttgcga agaagattgc 1378381 tgaagcggcc aaagaaaaag cattgttcgc tttagacgct cctgtttccg gtggagacat 1378441 cggtgcacaa aacggaacac tcgcgattat ggtcggtgga gaaaaagaag cttttgaagc 1378501 ctgcatgccg attttctctt taatgggaga gaatattcag tatcaaggac cggctggaag 1378561 cggacagcat accaagatgt gcaatcagat tgcaattgca gccggtatga tcggtgttgc 1378621 tgaagcgatg gcttatgccc aaaaatcagg cctagagccg gaaaatgttc tgaaaagcat 1378681 cacaacgggc gcagccggaa gctggtcatt gtcaaatctt gctccccgta tgctgcaagg 1378741 caactttgaa ccgggatttt atgtgaagca ttttattaag gatatgggaa ttgcactaga 1378801 ggaagcagaa ttaatggggg aagaaatgcc aggcttgtcg ctcgcaaaat ctttatatga 1378861 caagctagct gctcaaggtg aagaaaacag cggaacacag agtatatata agctttgggt 1378921 gaaataaaaa aagattgcct gtacgaaaca ggcaatcttt ttttattatt ttccgatgaa 1378981 ttgttgtgtc cagatgcttc cagactcaac gtaaccaaca ccgatgtgag taaagttagg 1379041 gtttagaatg ttttttctgt gtccttcact gttcatccaa gcttttacta cttcttctgg 1379101 tgtcttttgg cccttcgcaa tgttttcacc tgctgttttg tagctgattc cgaaagattt 1379161 catcatatca aacggtgagc cgtatgttgg gctttggtga tcaaagtagt ttttgtcttt 1379221 catatcctga gattttgcgc gtgcagattt gcttaacgtt tcatcaattt gaagcggttt 1379281 taagccttgt ttttgtcttt ctgcatttgt aagttcaaca acttttttct catatgcact 1379341 tacagatgaa ggtgcagacg ttgttgtgtt tgttttttca gcagttgcgg gtgctttaga 1379401 agcagtgttt tgatcagcag ctgctttttc agtagtcttt tgtgcaggtt ttgccgtttc 1379461 tgtcttttga acatcctgaa ctttcacgtt agattgcttc gcatgttttt gaagaagctg 1379521 cttcatctct ttttcgtttg cagcgtttaa cgttttgata tttgtgttaa tatgcagttt 1379581 tttcactgca tcgttaagtg acatgttttg tactgtgttc cccgttttta ctgtaaccac 1379641 aggctggcag gagagttctt tcgctgatgc ttgctgtacg cccccgaatg tgaataatcc 1379701 aaccgcagcg gcagcagata aaataaatgc tttcttcatt agttcgtaac ctcctagagt 1379761 tgtttgtttc tacagaaaaa tcataacata gcttttttgt cataaagatt ccagcacttt 1379821 cctttgacaa atagagattg tcattttcgt aaagtaaatc cgttgaatca ctaagaataa 1379881 gggaatcagc ggtatatatg attttatcgt accgttacat agcttccttt tttttgaacc 1379941 gttagttata ttttaatgtg tttttatatt gacagctttt tttactcctt ttcgctgtaa 1380001 caactattac aaaggtgtta caattaatct cagtatatgt aaatatattg aatgatttga 1380061 gaggggtaac cagaagtgac tgaaatagga cgtgaaccaa agaaaaagag caaaggaaac 1380121 agagcaatca gaatgaacct ttttttccta gctgtctttg ttctattcac tgcattaatt 1380181 tttaagctcg gggttgttca aattgttgaa ggcgaacagc atgaagaaga cgctgagaaa 1380241 tcaaatgcaa aaacagctta ctatcctgcg cctcgcggga agatgtacga cagaaaccag 1380301 aaagttgctg tcgacaacca gagcgttcca gaaattgtgt atgtatcaac atctagcaca 1380361 aaaacagaag ataaaatcaa aacagcgaag cggcttgctt ctttcattca tattgatacc 1380421 gaatttttga aggaaaggga tcttcgtgat tactggatcg cagctcatcc gaaaaaagcc 1380481 gccgctctgc ttaaggaatc agaaagcaat ctgaaaggag accaggctta caagcttcaa 1380541 atagagcgtg ttccggatca agaattaaag gctattcagc aagatgacga agaaatggaa 1380601 actgctgcga tatatacaag gttttcaagc ggaaatgctt acgaacctca aatcgtaaag 1380661 gcaatgaatc caaataagag caatagcaat ggaaaaaacg gagcgctgct tgatgagaag 1380721 aaaaactcct cgcaaagacc aaaaaatgac ttaacatatg atgaaatttc cattgtttct 1380781 gagcatttag aagaacttcc gggaatcgat atcgtaaacg attggacacg aaaatatcct 1380841 tatgacaaaa ccctttattc tgttttcggg ggcgtcacga cacctgatca gggcctgctg 1380901 agcgaccgga aagatttcta cttaacaaga ggctatgcga ataatgacag ggtgggaaaa 1380961 agttatttag agtatcaata tgaagaatat ttaaattcgc ataaagaaaa agtggaatac 1381021 gtagaagata ataaaggaaa tgtcgtcagc caaaaaacca ttgataaggg cagcagggga 1381081 tacgatcttc agctttcttt tgacatggag cttcaggcaa aggtagaaaa gatcattgaa 1381141 gaagaagtaa gaaacagccg tgcacgcgga aattacatgc ttgacagagc ctttgccgta 1381201 atgatggacc cgaataacgg cgatatttta tcaatggcag ggaaaaagat agatttaaaa 1381261 accaacaaaa ttgaagatta tgcgataggg gcatttacca cccaatatga aatgggatca 1381321 gcagtaaagg gggccaccgt gctagccggc tatcaggacg ggatcccgca ttataaatat 1381381 tatatcgatg ctccaatgct tttaggaacg aatcttataa aaaaatctta tactaatatg 1381441 ggaaccatca atgaattaac cgcattgcaa aaaagttcaa acgtatatat gttcaatgtt 1381501 gccatgcata ttgcaggcgt aacatacaag ccgcatggat ctctcccggc tgatcagaac 1381561 gatctactga aaatgagaaa ctattacagc cagtttggtc tgggagtaaa gacaggtatt 1381621 gatctcccgc aggaatcagc cggaatgcaa accacaccta aaactgtagg aggattaatt 1381681 ttagacttag caattggcca atacgataca tacacaccgc ttcaaatggc tcaatacatc 1381741 tcagtaatcg ccaatggtgg ctatcgtgtt cagcctagaa tcgtcacaag tattcataag 1381801 ccaggaaaaa aagaccagct gggtaaggcg attgaacata ggaaacctaa agtactcaat 1381861 aagattaata attcagagag cgatttgaaa caagtacaaa caggcatgaa attagtcact 1381921 tcttcaggga cagcaaaaaa tacgtttaca gaagatgtat cagggaaaac gggaacagcg 1381981 gaaacatttt actacggcac gaatcgcaac tggtggggga aaaaaacata caatctgact 1382041 tttgtcggct attacccgtc gaaaaaacca aaagtggcct ttagtgttgt tgttccatca 1382101 gtagatgatg atgataagat caataaaatt attgccaaaa gagctatcca cgcctacgca 1382161 gagctcgaaa aaaaacacag taaaaaataa aaaacagggt gcacaactaa aagattgtgt 1382221 gccctttctt ttattcaaaa attgacgttc accataagaa tagaaggaga atactcattt 1382281 tctagcgaat catactaggt aaaagtcaat ctgtatatgt cgaaacacga tgatcatgca 1382341 aaggagggat tctgtggaac aggatacgca gcatgttaaa ccacttcaaa caaaaaccga 1382401 tattcatgca gtcttggcct ctaatggacg catcatttat atatctgcca actccaaact 1382461 gcatttgggc tatctccaag gagagatgat cggatcattc ctcaaaacgt ttctgcatga 1382521 ggaagaccaa tttttggttg aaagctattt ttataatgaa catcatctga tgccgtgcac 1382581 ctttcgtttt attaaaaaag atcatacgat tgtgtgggtg gaggctgcgg tagaaattgt 1382641 tacgacaaga gctgagcgga cagaacggga aatcattttg aaaatgaagg ttcttgaaga 1382701 agaaacaggc catcaatccc taaactgcga aaaacatgaa atcgaacctg caagcccgga 1382761 atcgactaca tatataacgg atgattatga acggttggtt gaaaatctcc cgagtccgct 1382821 atgcatcagt gtcaaaggca agatcgtcta tgtaaacagc gcgatgcttt caatgctggg 1382881 agccaaaagc aaggatgcta ttattggtaa atcgtcctat gaatttattg aagaagaata 1382941 tcatgatatc gtgaaaaaca ggattatacg aatgcaaaaa ggaatggaag tcggaatgat 1383001 tgaacagacg tggaaaaggc ttgatggcac acctgttcat ttagaagtga aagcatcccc 1383061 gaccgtctac aaaaaccagc aggctgagct gctgctgctg atcgatatct cttcaaggaa 1383121 aaaattccaa accatcctgc aaaaaagccg tgaacgatat cagctgctga ttcaaaattc 1383181 cattgatacc attgcggtga ttcacaatgg aaaatgggta tttatgaatg aatcgggaat 1383241 ttccctgttt gaagcggcta catatgagga tttaattggc aaaaacatat acgatcagct 1383301 gcatccttgc gatcacgagg atgtaaaaga gagaatccaa aacattgccg agcaaaaaac 1383361 agaatctgaa attgtcaagc aatcctggtt cacctttcag aacagggtca tctatacgga 1383421 gatggtctgc attccgacga ccttttttgg tgaagcggcc gtccaggtca ttcttcggga 1383481 catctcagag agaaaacaaa cagaagaatt gatgctgaaa tcggaaaaat tatcaatcgc 1383541 agggcagctc gcggcgggaa tcgcccatga gatccgcaac cctcttacag cgatcaaagg 1383601 atttttacag ctgatgaaac cgacaatgga aggcaacgaa cattactttg atattgtgtt 1383661 ttctgaactc agccgtatcg aattaatact cagtgaactg ctcatgctgg cgaaacctca 1383721 gcaaaatgct gtcaaagaat atttgaactt gaaaaaatta attggtgagg tttcagccct 1383781 gttagaaacg caggcgaatt taaatggcat ttttatcaga acaagttatg aaaaagacag 1383841 catttatata aacggggatc aaaaccaatt aaagcaggta ttcattaatt taatcaaaaa 1383901 tgcagttgaa tcaatgcctg atgggggaac agtagacatt atcataaccg aagatgagca 1383961 ttctgttcat gttactgtca aagacgaagg ggaaggtata cctgaaaagg tactaaaccg 1384021 gattggagag ccatttttaa caacaaaaga aaaaggtacg gggcttggat taatggtgac 1384081 atttaatatc attgaaaacc atcagggagt tatacatgtg gacagccatc ctgaaaaagg 1384141 cacagcgttt aaaatttcat ttccaaaaaa ataaaaacaa cggcttaaac gccgttgttt 1384201 atcgtctgca ttgcttcacg tttttttaat acaaataatt ctaaacggtc taggccttct 1384261 ctcagcgtgt ccattgagca tgcaaaagac agccttacat atccttcacc atatgttgag 1384321 aacgagctgc ccggcacgag tgccacgcca gcgtcttcca aaagagccat actaaaatca 1384381 aatgaagtca ttccaaatga tttaatagaa gggaagatat aaaacgcacc ggacggttta 1384441 actacgtcaa gtcccatgga aacaagacgg tcataaacat agtccagacg ttttttgtat 1384501 tgttctctca taatcaatgc atcgtcaaag ccgtttgtga cagcttcaag cgcggctttt 1384561 tgagaaatgg atgaggcgca cgacacattg tattgatgaa cctttaaaat gtgctttgca 1384621 atgtctttcg gtgcaaataa aaatccaatt ctccaaccgg tcatgctgtg tgattttgac 1384681 aacccgttaa tgacaatcgt ttgatcccgc aaataggttg cgatggagta atgcggtctg 1384741 tcatatgtta attcactgta tatttcatca gacaatacga agacatttct gccttttaag 1384801 agagctgcga tgcttttcag ttcttcttca gataaagtca cgccggtagg gtttgacgga 1384861 taaggaagca cgacacactt ggtgttgggt gtcagagcat cttcaatcag ccgggcggta 1384921 agcttaaagc cgtgtgacgt agtatcaaca atgacaggct tggccccgca caaattgata 1384981 ataggttcat agcccggata aataggccct ggcataatga cttcatcacc gggagataaa 1385041 atcgtccgga atgcagcatc aatggcttgg cttgcgcctg ttgtgatgat aatttcagat 1385101 tcagcatcat agttgaaatc cgcttttttc ttcatataaa gctgcacagc ttgtctcagc 1385161 tccaggtagc cggcattcgg agtatatgac gtcacgtttt catcaatggc tttttttgcg 1385221 gcagctttca catgatgcgg tgtgaaaaaa tcaggctggc cgattgtaag tgaaatgacg 1385281 tcttcgtgtt gggctacaag attcgagaat ttgcgtattc ctgaaatttc gatctctctt 1385341 gctttcggat tcagcaaatg ttccataatt catcacctta acaaatataa tgagtttatc 1385401 ctattttacc actagctgat catttgtcac ctttttaact gatatatttc gattgtatgc 1385461 gccttttttc taaacatacc tttcttttca gaaaaaaaga agacaaccag cgatttgatt 1385521 gtctttattg tatcatgttc tattattgtt tatatgtgcc aatttcatta atagccataa 1385581 tcaaaatgaa ggtcttcgtg ccaaatcaga tacggaggat gctcttcttg aaggtcagct 1385641 gattctttct tcatattcag gtaagtttct tcactgatat cctctaaaac agtcatttcg 1385701 ttttctttaa atattactaa ggtacccatt atttacaccc ttctttggaa aaatccttga 1385761 ctattttatc actgttagtt ggaaagtcaa tggttattag gaaaaaagtt tcttttttga 1385821 ggaacgcggc ttgttgcctt cggaattcga ttttgaagag ctgccattca ctttttacaa 1385881 attacgccga tatatacagt acaatactga atgcgaatag cgagggattg aattgtcgtt 1385941 acaacaatac gaaattttat tggattctgg tacaaatgaa ttagaaattg tgaagtttgg 1386001 cgtgggtgaa aatgctttcg gaattaacgt catgaaggta agagaaatta ttcagcctgt 1386061 cgaggtgaca tcagtgcctc actcccatca gcatgtagaa ggaatgatta aactcagagg 1386121 agaaatcctc cctgtgatca gtctcttctc attttttgga gtagagcctg aaggatcaaa 1386181 agatgagaaa tatatcgtga ctgaatttaa taaacggaaa attgtttttc atgtcggctc 1386241 tgtttctcaa attcacagag tatcctggga agcgattgaa aagccgacat cgttaaatca 1386301 aggaatggag cggcacctta ccggtattat taagctcgaa gacctgatga tctttttgcc 1386361 tgactatgaa aaaattattt atgacattga atcagattca ggtgttgaca cgtataatat 1386421 gcataccgag ggcttcgatg aaagaagaac tgataaaaag cttatcattg tagaggactc 1386481 accgcttttg atgcgcctct tgcaggatga attaaaagaa gcagggtaca acaatatcgc 1386541 ttcgtttgaa aatggaaaag aggcatatga atacattatg aaccttgctg aaaacgaaac 1386601 tgatttatca aaacagattg atatgatcat cactgatatt gaaatgccaa aaatggacgg 1386661 acacaggctc acaaagctgc tgaaggaaaa tccgaaaagc tcagatgtgc cggttatgat 1386721 tttctcatcg ttaattacgg atgatctgcg tcaccgcggc gaagttgtag gcgcagatga 1386781 gcaaatcagc aagcctgaga tcagtgattt gattaaaaaa gtggatacgt atgttattga 1386841 ataaataaaa acagccgttg ccagaaagag gcacggctgt ttttatttta aaagtaactc 1386901 tcgccaagtt ttttaaagac cggtttatgg taagctggct gctggcgatt tggcactagc 1386961 ggcttttctt tcatgccgac atattcttgc aataggtgtt tcgcttttgt taaagacatt 1387021 tgagctttag gatttcgata cgattgatta agtgtaccta aatgcggaag atgttcgaag 1387081 tcttctttag ttggaggcat gtgaaaatag tagtctccga ttgagataag cacgtccgat 1387141 tgctgttggc tgaaccttgg attttttgaa aaatgaagcc ctattttctt tcctttacct 1387201 tctttgacaa gcttttgcaa agcccgtttt ttcagcagat ataggtattt agggttgggg 1387261 gcggtttttg catggcggtt cacagtgtaa actgcttttg aaagattttc tacggttggc 1387321 tgcagatctt tcgtatatgc atggtcgtcc attatttctc tcctttgctc ttatcaattt 1387381 ctatatgttt agattatact tttttaaagt tgaaatgcaa atattgaatg taaaaatgcg 1387441 cttttttcta agaaaaaaag cgcattttta acctgcatta tacagatctt gccttctttt 1387501 tcggctgttc ttgaaatgct tcctgaacat tcacttccac agcctgagca ctgtattttg 1387561 gcagtgcaat aaaataaaaa ataaaaacga gcaggataat aacacccatg ccgtaataaa 1387621 gataatcaat gtttgaaaca aacttaggga ataacagcgc gactaagccg agtgtcaaag 1387681 attgtgcaaa catcataaaa gggtcctgca tgccgcttac acgtcccatc agttttggat 1387741 gaacaatttt tggcatccac cctccgattg caatgttgat cggtccgata cacattccca 1387801 gtgcaaaagc tgccgcgtaa tacacccata aaatattggt gtagccgagg acgaagatca 1387861 gcaaacctgc aatgaaaatc ggtatcgaca ttaaaaagtg cggcttcact tttttagaga 1387921 tgagcgtgcc gattacgctt cctgccagaa gcccaaaccc gagtgcgatc gtaaatacag 1387981 acgtatgcca ctcataacgg tcaggcgcca atccatattt cattgtaaac atcggcaata 1388041 cggcgaatcc tccattgaca aatccaaaaa tgaagaagcc aaaaataaga gatgccagca 1388101 atttgttttt taaaatatag aggatgcctt ctctaaagtc atttattgaa tccttaacag 1388161 aagtctttct ccagctgaat gcaccgtttg gctgtcgggc ttcttttgga atccggcagc 1388221 tgcggatcag cagcccggaa atgataaagc tgacaaaatc aagaataatg gcgccttcaa 1388281 taccgattgt gttgtacata aacgcgccta tgccgactcc aaacaccata aaaatgctaa 1388341 aaagcatctg attaagccct gccgctttcg cataatgctc cttcggcaga atggcttgta 1388401 ccaaactgtt ttctgccgga aagaaaaact ttgttacagc gcttctgata aataagatac 1388461 aaaaaacaag aggaatattg ccggtaaata aagtgaaaaa aagcacgaca gtcaggcctg 1388521 ctctgatcca atcacaattt tctgccacct tttttctatc aaaccggtcc gcgacgactc 1388581 ccacgatcag aaatacaaat atggtcggaa gagaatacat cagctccgcc aaggtcgtat 1388641 atgaaggctg gctgctgaat cggtccagca aaaaaaaagc aaaggccatg ttgcctactg 1388701 tcgtgcccat ttgagaagcg agtgctgcga aaaatagacg aacaaaatta cgatttttaa 1388761 atatatccat aaaaacgctc cttaccctaa aggtcccact ttatcatatt ataaaccgcc 1388821 tgtttttgaa acaaataaga aaacattacc ggttaatcgt gactctcgtt ccgtttggca 1388881 caattgaagc aagttcgatc acgtctttgt tatgcatgcg aatgcagcct ttagaaacag 1388941 ccttaccaat cgaagcggga ttattcgtcc catgtattcc gtagtgctgc tttgaaaggc 1389001 tcagccaata agcgccaaat gggccgccgg gattgcgctg gcggttaata atgtaaaact 1389061 cgccagtagg cgtttgcgtt agtattttac caacggcgat gggataggtt ttcattaccc 1389121 gattatttag ggacagcgta agggtcttcg ctccgattga gactgcgata tgatacggaa 1389181 ttgtataagg gtccggcagt ccggggatga ctatggactg tcccgcggtg agccctgcct 1389241 gcagtgacgg attagcctgg agtaatgcag ccgtgctgat tctgaaatca gccgcgatgc 1389301 tgttcagtgt atcaccttgc ttcacctggt acgtaagcag tttcctcatc ctcctttttt 1389361 acttataagt attgatgagg agcccatcct gctacattaa tttgtgcttt ttaaggtgaa 1389421 gacagtgatt tcaggcttgg caagaaaccg caaaggcagc ctggtcatcc cgaggcctcg 1389481 gtttacgtaa atatgagtgc tgcccgtttg atacattccc tctgtgtaga cttttccata 1389541 tggaggcgta ataatcggtc cgtaaaaagg cagctgaatc tggccgccgt gtgtatggcc 1389601 ggaaagctga aggttcacgg gataatctgt tgttttcaag gctgcatcag gttcatggac 1389661 gagaagaatg gaaaaaagtc tgtcgctcag ccttgaaagg gtgccttcat aatctgggtt 1389721 tcccagcatt aagtcatcaa gcgaagcaat ctcgattttg ctgccatctg cgagtgacaa 1389781 tgtttgatag ccattgcgat ataccgtgaa acctccggcc gtcatcaggc ttttgtaaac 1389841 ggcagttcca tagcctccgt gatcatgatt gccgtaaata caaagcttgc cgaagggagc 1389901 attaagcttt ctcaataatg gaatgactgc ctggtggtgc tggtacgtat caggattatc 1389961 aataatatca cctgtaaaaa caatgagatc aggtttagat tcattaattg taagaatgac 1390021 agtttttaaa tcttcgagag taaagtaatc actcaagtgt gcatcgctga actgcacgat 1390081 tttaaaaccg tcaaatccgt gcgggatgag agagcttttt attgtgtgtt cggttgtctc 1390141 gatcatatgc ggctcgagat acctggcata gccatatccc ccgccggccg ttaaagcccc 1390201 ggcagcaaga gcgccgaaca ttccttttag aaattgtctt ctggacatct ttttcatttc 1390261 aaaccaacct ttaatagagt ttttctatta tatcatctgt atctgataaa aatctcatat 1390321 gagcatgtgc tgacagaggc agggatataa tgatagaata ttattgaatg aataatcatt 1390381 cacaattgga gggataaaca tggaaaaaaa ggcggtaatt attaccggcg ggtcaagcgg 1390441 catgggaaaa gcgatggcaa aaaaacaggc tgaattaggg tggcacgtta tggtgacagg 1390501 gaggaaccat gaggcacttg aggaaacaaa aaaagaaatt cagacctttg agggacaggt 1390561 cgcttgtttt caaatggatg tccgttccga ttccgccgct tcagacatga ttaaagaagc 1390621 ggtaaaagcc tttggccggc ttgacgcgct gattaacaac gcggccggaa actttatttg 1390681 tccggcagaa aagctgacgc ccaatggatg gaaagccgtt attgagattg ttttaaacgg 1390741 cacatttttt tgcagccaag cagcggcaag gcattggatt gaccagaagc agcagggtgt 1390801 cattttaaat atggcagcca cgtacgcttg gggagcggga gcgggggtcg ttcattccgc 1390861 tgcagccaaa gcgggggtat tgtcattgac aagaacgctg gccgttgaat gggggagcaa 1390921 atacggcatt cgtacaaacg cgatagcccc cggaccgatt gaacgaacag gcggtgcgga 1390981 gaagctattt gaatcggaaa aagcgatggc ccgcacgatg aacagtgtgc cgctcggccg 1391041 attgggcaca ccggaggaaa tcgccgcttt ggcagcgttt ttgctttctg atgaagcatc 1391101 ctatataaac ggggattgta tcacaatgga cggggggcaa tggctgaatc cttatccgtt 1391161 ttaatctgaa tatttataag tgaatattta agttattaag aacttttatg ttcgaatgta 1391221 atacctccac aattaacctt cttcctatcc aatttgataa cacatagagc tttatttgtt 1391281 tatgaggtgt tgtgtcatac gtaagccacc taatatatga aaggtatatt ttaaaagggg 1391341 agacgaaata tgaagaactt agatttcaaa taaaacattc atataattac ttcgttaact 1391401 aaaaagagaa attataagaa tgaaaggttt caaggttaca tcagattggg aggaaggtaa 1391461 tataatggac gagatggtat tattaactca ggaatggctc aatgaaacgt acaaaggaaa 1391521 aagtggctac aattccattg aggaaaatgg gaaaactggc tggaaaacaa tgtatgcatt 1391581 aactagagca ttacaactag aattgggaat tacacagact tccgacagtt ttggtcctac 1391641 aactttaaga aagcttaaag aattaggccc gatttctacg tcaactaatt caaaaaaaaa 1391701 tattgtgaaa attattcaag gtgctcttta ttgtaaaggt tatggtccag gtggattaac 1391761 gggtacattt ggtcagggaa cgaaagaggc gatagcagaa atgcaattgc atatggggct 1391821 ttctaaaaca gacggtgtag taacgcctaa ggtgtttaaa gctttattaa acatggactc 1391881 ttatatcctt ttaaatgggg cgtcagagaa agttcgttca atacagcaat ggctaaataa 1391941 taaatattac aatagagaga atttctactt tatgccctgt gatggcctgt attcaaggga 1392001 tactcaaaag tctcttgttt atgcaataca gtacgaggaa gggttaagtg atagtatagc 1392061 taatgggaat tttggaccaa ctactcaaag attgattcct gtattaagaa ttggagaaac 1392121 agatgaaaaa aacagtttta ttcatttatt tcaagctgct ctaatcttta atggctacaa 1392181 tgttcctttt gatggagtat actctgaatc tgtaagatca aaagtaaagg cttttcagtc 1392241 ttttgcaaaa ttacaacaga gtggtactgc cgactttcaa acatgggctt cacttctagt 1392301 aagtactgga gaccccaatc gaaaaggagt tgcttgtgac tcaattactc aaattacatc 1392361 ggacagggcg gagtccctta agagggcagg ttataagatt gtagggcggt atctaacaaa 1392421 tgcgccgggg agtacactaa ataaaaaaat acaaccaggt gaattagaaa ctatcttaaa 1392481 atcaggttta aatgtttttc cgatttatca aacctatggg ggagcaacaa attattttaa 1392541 taaagaacaa ggaaagaaag atgcgtttgc tgcttataaa gcagcaaaag aatacgggtt 1392601 taaaaataac actgtaatat actttgcagt agattatgat gcatatggta acgatttaaa 1392661 caacaatatt attccacact tcgaaggtat aaatgaaata atgaacggtt ttttaggttc 1392721 aacttacaaa attggtattt atgcccctag gaatgtatgt actatagttt ctaaaaaagg 1392781 tttagcattt gcaagttttg taagtggtat gtctactggc tttagcggaa acttaggata 1392841 tcctttgcct tacaattggg cgtttgacca aatttcaaca attactgttg gaaatggttc 1392901 tggaatgatt gaaattgata atgatatttg ttcaggtttg gataatggag ttaataccat 1392961 aaatatagtg ccttcagaga ataagaagtt ttttgatcaa attgatgttt tatatgaaac 1393021 tgctgaaaaa tatgctcaaa tgcaaagcga cttaaataat ggggtaaaaa aaacacaatt 1393081 agctaatgag ttggttgccc agtatttaag aaaggatgac tacaaagggt ggaagtgggt 1393141 ccctaccgca ggccagattg atcctattta tcgtgaatgg gcagtaaagc gctaggggaa 1393201 gacctagtaa atggaattgt tgatcctata tcaaaaactg tcataggaac gcagcatctt 1393261 atggcaactt ataatgccat tatttatagt ggtggttact ctcaaacact acgagatttt 1393321 gctggttgga ctggagatct attaacaaca atacaggaca tgaaattaca cgctcaagaa 1393381 tttaattcgc cttatgatgc ggctatgaaa ataataggta atatgtatca atttagccta 1393441 gatgatttat ttagtgatgt agatgcaatt aatctagcga ataaaacatc agttggtgct 1393501 aatgcacaac ctctaaatat cgcaattaga gattattata gtaataatga ctgtatgaat 1393561 aggttcactc aatttgtaaa taatagattt gatggttcgt tagacaaaat tttctctgaa 1393621 gcagagtatt atttaaatac aaaccttgac ccagttgttg ttccaattag gttagccttt 1393681 aaacgtgctt ttgatgttga ggattatagt gaagagattg gaaaaataac agcacaagca 1393741 tttagagatg ttatcgagaa aaaaatgata tctgaataaa ctgcaaaaca agcgaacgtt 1393801 aaaactggtc gttcgcttgt tttattttct atttaaattt atgatataat ttttaaagat 1393861 taaggagtga ttcattgaag aaattgttaa aaaagttagt tgtattattt ttaagcagtt 1393921 tagttatcat ctttaatgtt tggtacttta ttatttgtgc tttttcccca gagtattatc 1393981 aaaatacaaa tcttacttct aatgaaataa taagatttga aaaactatac cacatagatt 1394041 ttcctgatga aacaaaattt attaaagcta gagagtattt ggctgggccc ggaggagata 1394101 cgtcagctgt attatatgtg tctctgccaa ccaagcgggt agaaaaagtt ttatctgatt 1394161 acacgtatat gaaaataaac tatactgaca atgtcggttc aatgtatgga gttgacgttt 1394221 caaagagtgt cgccggttta acaactctta catttggcac ttacgataaa aaaggaactt 1394281 tctataatat gaaacatgat gatgattgga tgtataaagg cactgactgg aatctttact 1394341 tttggacagc tgctagttat aatgctgtta tttttgtatt tgttttggtt attgtgaaac 1394401 aaatgaataa aattcttaat taaccagtat gtagattgat aatctcaaaa aaattttcct 1394461 cttcttttaa catactccat acgacctact tttccatact atgatttttt tgaaatttgt 1394521 ggtgtagtta taattgtgcg tataatcaga caaagataga gaagcaggtg ataacatgtt 1394581 ggatccactt gatattttaa cgaacattga tgatgtcctt ccatattacc aggcgatttt 1394641 tagtgccgag gagcagaagg ttgtcggata tgaggtgctt ggacgaattt tggcagattc 1394701 agaaatccaa agtctcgggc ccttcttttt agatgcgggg atacccgaag aatataaatt 1394761 agaggttgat aacagaatta tccgccaggc tcttgaccgc tttttagagg cggattctga 1394821 tctgctgatt tttatgaatc aggatgccaa tctgctgatg ctggatcatg gtgaaagctt 1394881 tctggagctt ctgaaagaat atgaagcgaa gggaatcgaa ctccaccgtt ttgtgcttga 1394941 aattacagag cacaattttg aaggggatat tgagcagctc taccatatgc ttgcatacta 1395001 tcgtacatac ggaattaaaa tcgcagttga caacatcgga aaagaaagca gcaacttgga 1395061 cagaatcgcg ctgctctcac cagatctgtt aaaaatcgat ttgcaggcgc tgaaagtgtc 1395121 acagccgtca ccgtcatatg agcatgtgct gtacagcata tctttattag caagaaaaat 1395181 cggtgcggcg ctgctgtatg aagacattga ggcgaacttc cagcttcagt acgcctggag 1395241 aaacggaggc cgctattttc agggctatta cttagtgtct ccatctgaaa cgtttctaga 1395301 gagagatgta ttgaaacaaa gacttaaaac tgaatttcac caatttatca cacatgagaa 1395361 aaagaaactg gagaccgtct atgagcactc tgaacagttt tacaaacgag tgcatcaggc 1395421 tgtgacctct ttgagaaaaa acaatctgtc ttctgatgat gactttatta aaaagctggc 1395481 ggaagagctg acagattgca gcttcaggat ttacatgtgt gatgaagaag gcgatcagct 1395541 gacgggaaat gtgtttaagc aagatggaga atggatttat cagccggaat atgcggaaaa 1395601 gaactggagc tggcgccctt attttctgga gaacattatg agaatgagaa atctcagaaa 1395661 aggttttttc agtgatctgt acagtgattt ggaaacaggt gaaatgatca gaacgttttc 1395721 atatccgatg gatgatcaga tgtatttatt tatagacttg ccttattctt atttatatga 1395781 gcaggacgga ctgatttaac ggctgaaagg ccgttttttt tatgaaatga aaaaaatatc 1395841 aaaaaacgat tgacattgat actgagaatc attatcattt aattatagag agaagctact 1395901 ctctgttccc caacccctct atcagatcaa gatccgaaaa aacttggcgc tacccccgcc 1395961 aagtttttta tttgtcaaag cataggacaa tccaatgaaa caataaacct aactagtggt 1396021 aaacgtttaa cacggggaga aacattgagt gccgaacacc cctgacactg ctgcacgggt 1396081 gaggaggaaa attcgttctg aaatgattat ttcagttccg ttgtttacct ctatccagca 1396141 tgactcccat tgattatggc cacgcgggac ttcaccataa aattcaaaag aaggttttga 1396201 caaagttgca aaaaggcatt cttaatgctg ccaaagattc gaaaaaaatt ataattatgt 1396261 gcatgacatt caaaaaaagc ctcaaactaa agaaaaatag tttttttcac tttttttctt 1396321 tgcttaaatt cagcagtgaa aatgccatcc tgtccgactt tatggtatga tgctcaatag 1396381 aacttgtatt ataataaata cttgttgatt tgaagttgct ttttgaaagg agtctttttt 1396441 tagaatgtca caattaatgg gtatcatcac acggctgcaa agtctgcaag aaacagcgga 1396501 agcggctaac gagccaatgc agcgttattt cgaagtgaat ggtgagaaaa tatgcagtgt 1396561 taaatatttc gaaaaaaatc aaacgtttga actgacggtt ttccaaaagg gtgaaaaacc 1396621 taacacatat ccgtttgata atatcgacat ggtttccatc gaaatctttg aacttcttca 1396681 gtaagattcc tgaaataggg ggaacaagct tccgcctttg caaaagtaat cgaaataaac 1396741 ggtaaggaac atacttgttt catggttgta aatccttgaa aaggagtgtc gtgatggctg 1396801 attcttttct gttttataat ctttcagaag cacagatgac ctttcaagat gtgatggaac 1396861 ggcttaaagc ctttgttcaa aaggaccccc gttcttctta tgtgttatcg atcggaaccg 1396921 attcacaggt ttaccgcgat tacacaaagt ttattaccgc attgcatttg catcgtacag 1396981 gcaagggagc ttggggctgc ttgaaaaatc atacagtcga cagacccata catagccttc 1397041 gggagaagat ttcgttagaa acggcgtaca gccaagaaac ggccgctcat attcttgatg 1397101 gacacttaat ggatattacc gatctgctcc tgccctttac cggtgagggg gcggatctta 1397161 cctttgaagt tcacttggat attgggaaaa aagggcttac aaaagatctg atccaagaaa 1397221 tgactggacg tattacctcc atggggattg aggccaaaat aaagccggat tcatacactg 1397281 ccttcagcta tgcaaatcgt ttcacaaaat aatttggctg aaaaagccaa ggtaaatgtc 1397341 gaattatgcg gttgacgttt gttatctgat tacttattct agcggtagag ctgaaagtaa 1397401 gttgtcttgc tttcagaggt attcagtata aaacaggggg cctgattgcg aatgagtctt 1397461 atcggtgaac gatttacaga agaagaacaa aaacttctgc tgaatatcct gatcaaccat 1397521 gagtatgcca tcgagctatt aagcagtgag atcaacgata tagagacagg gaccaaaaac 1397581 gttgacggaa ccacctacaa aaaacttgta acgctatacg accgatttcg atttgaaaat 1397641 taatgggaca ccctataatt gatactccac aaagagtatc ttttttattg aaaggaaact 1397701 tttcgacaaa tactgataaa gtttatatta ttgcaatata gggaatgtat tgatgatgaa 1397761 aatgaaaagg ggtcgaaaac atgataagct tacaatcaga tcaacttctt gaggcaacag 1397821 tcggacaatt tatgattgag gcggacaaag tagcgcacgt gcaagtcgga aataaccttg 1397881 agcatgcatt attagtattg acaaaaaccg gatacacagc catcccggtt ctggatcctt 1397941 cctaccgttt acatggctta atcgggacaa atatgatcat gaacagtatt tttggacttg 1398001 agcgaattga gtttgaaaag cttgaccaaa tcactgttga ggaagtcatg ctgaccgaca 1398061 ttccgcgcct tcatatcaat gatccgatta tgaagggatt cggcatggtc attaataacg 1398121 gatttgtctg tgttgaaaat gacgagcagg tatttgaagg gatttttacg agaagagtcg 1398181 ttttaaagga attgaataag catatacgct cattgaataa gtaggctgta cggtcctatt 1398241 tttattatat aggcagagtg aaaaaagaaa gcgcatacat aatttaaacg agaatagggc 1398301 ttgaataaga aactaagatt ttattagaat gggagataag aaaaacttat tgataacaaa 1398361 aaggaggacg acatgcagct tcaagagctt catatgctcg tagttttagc tgaggaatta 1398421 aatatgagaa aggcggcaga acggcttttt gtatctcagc cggctttatc tcagcgctta 1398481 caaaccattg aaaaggcgtg gggaacaaaa atctttttaa gatctcaaaa aggattaacg 1398541 gtaacgcccg ccggtgagaa aatcattcag tttgcgaatg atgtgacatt agagcaggaa 1398601 agaataagag aaaatattga cgagcttgaa ggtgaaattc acggcacatt gaagcttgcc 1398661 gtcgcctcca taatcggtca gcattggctc cctaaagtcc tgaagacgta tgtggaaaag 1398721 tatccgaatg caaagatctc gctcataacc gggtggagca gcgaaatgct gaaaagcttg 1398781 tatgaggatc aggttcatat cggcattata agaggcaacc ctgagtggaa ggggcgcaaa 1398841 gattacttaa tgacagatca tctgtattta gtggatactg aaatttcctg catcgaagat 1398901 attgcccata cagaacgtcc gtttatccag tttaaaagtg acagcactta ttttcaggaa 1398961 attcagcact ggtggcatca aaaatttaaa acgtcgccga aacagacgat attggttgat 1399021 cagattgaaa cgtgcaaaca gatggcgctg cacggaatcg gttatgccat tttgccgtct 1399081 gttacccttc aaaatgaaga taaagtgaat aaaatgcctc ttttagacat gaaagggcat 1399141 ccgatcggtc gggatacatg gttattaggt tatgagcctg cctttgaact gaaacaagtt 1399201 caagcttttg tacaagtgat aaaggatatg ctggatcagg aaaatccatt ttaaagacag 1399261 cgaggtgctg tctttttttt atttatctgt tgacaatgaa aatcattatc atttaaagtg 1399321 atacatatga tattgaaaat cattatcaac taatggggtg ataacatggc taaagccttg 1399381 attacatatg ccagcatgtc aggaaataca gaagacattg ccttcataat aaaagatacg 1399441 cttcaggaat atgagttgga tatcgattgt gtcgagataa atgatatgga tgcgtcttgt 1399501 ttaacctcct atgattatgt actgattggc acctatacat ggggggacgg cgatttgccc 1399561 tacgaagcgg aggatttttt cgaagaggtc aaacagattc agcttaatgg tttaaaaaca 1399621 gcctgcttcg ggtctggcga ttattcttat ccaaagtttt gcgaagcggt gaatttgttc 1399681 aatgtcatgc tgcaagaggc gggagctgct gtttaccagg aaacactaaa aattgaatta 1399741 gcgcctgaaa cagatgaaga tgtggaaagc tgccgagcgt ttgcgagagg ttttcttgca 1399801 tgggcagatt atatgaacaa ggaaaaaatc catgtttcat aaaggggcaa ccgctgttac 1399861 ggcatcggcg ttttctggat attttgtggc ggtacaaaga gaaggcattt ttcattactc 1399921 tttggagcag ggctggagaa agctttttcg tttgaaaagt aagatacact gtatcagcta 1399981 catagggcct tacttatttg gcgttggtga aaagggaaca gtcattcgtt cggctgatga 1400041 agggaaaacc tggacgatgt cgagctttcc gacaaatgca acagtgtggg cgattaccgg 1400101 cagaaacaac gggtttgtct gcgcccacgg taagcattgt atttatgtat cggatgattt 1400161 tggtgtctca tggcgcgtag ccaaaccttt tgccgaattt cataatcccc ctgttatccg 1400221 gtcgttatgc cttcacgggg gcaatctctt tatcggcacg caaatacacg aatattttgg 1400281 cggcatttgg gcttacgaca ttaagcgtga cactgtccaa gttgtcaaaa aagaaaaaaa 1400341 ccggatgacg gcatccatgc tcgtgttcaa tgaaaattgg ctggtggcgg cgatgggttc 1400401 tgtgaaagga aagcacggtg ctgtcactgt aaggaatctt ttgaatggtg aagaattcac 1400461 catacaatcc agtatgatca gaaatgaaga atcatttctt gatctttcag aggatgatgg 1400521 cattatatat gtcactacaa cacaagatga aaatggtttt tcgagaattt accaggttga 1400581 tctcgaagcc cggtcgttaa aatggttcga taccattaag ggacatggat ggagagtggc 1400641 caatcagaaa gagaatttct tttgcgcagg cttgtatgaa tgtaaatttg tccagccgta 1400701 cgaagtttca gcaatgattc attagaggag gaacaaggaa ttggcgaaga ttttgctcgt 1400761 ttatgcaaca atgtcaggca acactgaagc tatggcagat ttgattgaaa aggggcttca 1400821 ggaggcgtta gcagaagtag accgtttcga agcaatggat attgatgatg cccagctgtt 1400881 taccgattat gaccatgtca taatgggaac ctacacgtgg ggagacggag atctgcctga 1400941 tgaattttta gatcttgttg aagacatgga ggagattgat ttttccggca aaacatgcgc 1401001 tgtattcggt tccggtgata cagcatatga atttttctgc ggagcggttg atacgctaga 1401061 ggcaaaaata aaagaacgcg gtggagacat tgtgctgcct tcggtaaaaa tcgaaaataa 1401121 tccagaaggt gaagaagagg aagaattaat aaacttcggg agacaattcg caaagaaaag 1401181 cgggtgcgct gtctgatcac tcactgggaa ctgctaaaac ggctgttcct ttttttcttg 1401241 tctttgtatc tttcctttga tacagtaatg aggtagaaaa tcaggaggag gactatacat 1401301 atgaaaatga tggacgcaaa tgaaattatt tcatttattc aaaatagtac aaaatctaca 1401361 cctgtaaagg tttacgtgaa aggtgagctg gaaggaatca atttcggtga atctgcgaaa 1401421 gcttttatca atggaaacac tggtgtcgtt ttcggtgaat ggagcgaaat ccaaacagca 1401481 atcgaagaaa accaaagcaa aatcgaagac tatgtggttg aaaatgaccg ccgcaattct 1401541 gcgatcccaa tgcttgatct taaaaacatc aaagcgcgta tcgagccggg tgcgatcatc 1401601 cgcgaccaag ttgaaatcgg tgataacgca gtcatcatga tgggtgcttc tattaatatc 1401661 ggttcagtca tcggcgaagg cacaatgatt gatatgaacg ttgtgcttgg cggacgagct 1401721 actgttggaa aaaactgcca tatcggcgcg ggttctgtac ttgcgggcgt tattgagccg 1401781 ccatccgcta aaccggttgt gattgaagac gacgtcgtaa tcggcgcaaa tgctgttgtg 1401841 cttgaaggtg taacagtagg taaaggagct gttgttgctg cgggagcgat cgtggtaaac 1401901 gacgttgagc catacactgt cgttgcaggc acaccagcta aaaaaatcaa agacattgat 1401961 gaaaaaacaa aaggcaaaac tgaaatcaag caggaattac gccagctgta aggaaaagtt 1402021 tgataaaaaa ggcgtggata atatatccac gccttattcg tataggcagg aggaatagaa 1402081 atgaagatag aggagctcat cgcaattcgc agagatctgc atcgtatacc ggagcttgga 1402141 tttcaggagt tcaaaaccca gcagtattta ttaaatgtct tggaacaata tccgcaagac 1402201 agaattgaaa ttgagaaatg gcgaacaggg ctttttgtaa aagtgaacgg gacggcgccg 1402261 gaaaaaatgc tggcatacag agcggatatc gatgcgcttt ctatagaaga gcaaactggt 1402321 cttccattcg catcagagca tcacggcaac atgcacgcct gcggtcacga tttgcatatg 1402381 acaattgcac tcggcattat tgatcatttt gttcaccacc cagtcaaaca tgatttgctt 1402441 tttctgtttc agccggcaga ggaagggcct ggcggtgcgg aaccaatgct tgagagcgat 1402501 gtattaaaaa aatggcagcc tgatttcatc actgcccttc atattgctcc agagcttccg 1402561 gtaggcacca ttgcgacaaa aagcggcctt ctatttgcga atacatcaga gctagtcatc 1402621 gatctggaag gcaaaggggg acatgcggca tatccgcatt tggctgagga tatggttgta 1402681 gcagcaagta cacttgtcac ccagctgcaa acgattatct ctagaaacac agatccgcta 1402741 gacagtgctg ttattacagt tggtaccatt accggaggct cggcacaaaa tatcattgca 1402801 gaaacggccc acctggaagg cacgatccgc acgctttctg aagaatcgat gaaacaagta 1402861 aaggaacgga ttgaagatgt agtgaaagga atcgaaatcg gattccgctg caaaggaaaa 1402921 gtgacatatc cgtctgtata tcaccaagtt tacaatacga gcggattaac agaagaattt 1402981 atgtcttttg ttgctgaaca tcaactggcg acagtaattg aagcaaaaga agcaatgact 1403041 ggagaggatt ttggctatat gctgaaaaaa tatcccggat tcatgttctg gctcggcgct 1403101 gattctgaac atgggcttca tcatgctaag ctgaatcccg atgaaaatgc gatagaaaca 1403161 gcggttcatg tcatgacagg ttatttttct gtttatgcca attaagtaca aatgaaagaa 1403221 taaaattcca taaaatgagc actctagtaa acggaggtgt tcaaaaatgg ctaaaaaaat 1403281 tggaattgaa caatcgttat cagatgtaga agctgcttta aaagaaaaag gatatgacgt 1403341 tgtaatgatg aaaagccctg ctgatgctca aggctgtgac tgctgtgtcg taacaggtct 1403401 tgataataat gtgcaaggga tagccgatac ggtaacacaa gcacctgtca ttacagcttc 1403461 cgggatgacg gctgaagaaa tttgtagcga agttgagagc agaattcagt aataaaaaaa 1403521 ccgaagcaaa aagcttcggt tcttttattt attctgtttc tttagggaaa gcgcggtcga 1403581 acgcgttctt tatttctttt ctcaacactc gttcgactcg ccactgttcc atattttctg 1403641 ttttggcaat gaccctgatt acaatttcag aagtccccag ttcttgaatc ccgatgacat 1403701 ttgggccttc ttttatttgt ggaagagccg ctgccgtttc atcacaaacc tgctgtaaaa 1403761 tatgaatcat ttcatcaata tttctttcag ccggcacttt aatgtcaaca agagcctgca 1403821 tggtaccacg agaatgattg ctcacgtttg tgatgtttct gttggggatg taatgcagtg 1403881 ttccgtcaaa gctgcggatt tgagttgtcc ttaagccaac ctgctcgaca attccgtcaa 1403941 aggtggaaac ggtaatataa tctccgacat ccaattgttt ctcaagcaaa ataaaaaaac 1404001 ctgtcacgat atcactgaca agcccttggg cgccaaatcc gacagccagg ccgacgattc 1404061 ctgcccccgc taaaagagcg cttggatcat aatgaaacaa atctagaacc atgacgaaaa 1404121 atatgaaaat caatgtataa gcaaatatgt taagagtcag gcttcggagc gtatgtgcac 1404181 gtccgataga caagctattc tgctcctcga attttgcaaa cagatgttta atgattttca 1404241 tgcctaatga tcgaacgata aaatagagca atatcataat ggcgagttta atgagcagaa 1404301 caccggcatt tgtaatcagt cccgcccaat catattgttt aataaagtcc atgttgagct 1404361 ccttttctaa ttgattgctg cacattgaga ctagttaccc tgtacatgac catgttaaac 1404421 gttttattca aaaatgtcga agccaaagac atacatgatt tgttaaaaat tgactcagga 1404481 aatctgcttt tatataatgg cattgcaata taactaaaaa tggttaatca ccctttattt 1404541 tcatgcgatt ttgaccttta agccaaacaa taaattggag ggatacatat ggcagaacgt 1404601 atggtaggta aacaagctcc tcgttttgaa atggaagcag tccttgcaag caaagaattc 1404661 ggcaaagtaa gtcttgagga aaacatgaaa aacgacaaat ggacagtgct gttcttctat 1404721 ccaatggact tcacttttgt ttgtccgaca gaaattacag caatgtctga ccgctatgac 1404781 gagttcgaag atcttgatgc agaagtcatc ggggtttcaa ctgataccat ccatactcat 1404841 ttagcttgga tcaatacaga ccgcaaagaa aacggtcttg gccagctgaa atacccgctt 1404901 gctgctgata caaaccatga ggtatcccgg gaatatggcg ttttaatcga agaagaaggt 1404961 gtggctttgc gcggattgtt tattattaat cctgaagggg agcttcaata tcaaactgtt 1405021 ttccataaca acattgggcg tgatgttgat gaaacgcttc gtgttctcca ggcgctgcaa 1405081 actggcggac tctgtccggc taactggaaa ccaggccaaa aaacacttta attctttcca 1405141 agaacgaaaa gcggtctagc atattcgtta ggcctctctt ttaaaatagg agggaaaaag 1405201 caatgaaatt acgtcagccc atgccggaat tgacgggaga aaaagcttgg ttaaatggtg 1405261 aagtgacgag agagcaattg attggggaaa agccgacgct tattcatttc tggtccatca 1405321 gctgccactt gtgcaaagaa gcgatgccgc aagtgaatga atttcgtgat aaatatcaag 1405381 atcagctgaa tgttgtagct gtacacatgc cccgttccga agatgatctt gaccctggta 1405441 aaattaaaga aacagctgct gaacacgata tcactcagcc gatttttgtt gacagtgacc 1405501 atgctttaac cgatgcattt gaaaatgaat atgtacctgc atattatgtg tttgataaaa 1405561 caggacagct ccgtcacttc caagccggcg ggagcggtat gaaaatgctt gaaaaacgtg 1405621 tgaaccgcgt tctggctgaa acggaatagg tatctgacta aatagtattt cctaaaaacc 1405681 tgacctcatc aggtttttta tttgtgcaaa aagcaatgga agaagagtaa gaagcttatt 1405741 tttccaaatt tgggtatagg aattgatgat ttgtttgatt gatacgctaa aaaacacagc 1405801 taatttttga tgtttttcct caattttaga taaatctcat atctcataac tcgaaaattg 1405861 tagatattac actaaatttc tttaaagaag taagtaaaat atatattttc aacattatac 1405921 caaataaact agaaagcccc ttaatccctt gagaataaag gactcttttg aaaaataaaa 1405981 cattttcaga aaataaggaa tttttcatag agtaaatata atagtaaaat gctaaaataa 1406041 tagttgataa aattactttt gtaatctaat atcttaatta aagatgttaa ttttgatagg 1406101 gggtacattg aggaatgttt aatgaaagag aagctttgcg cttgcggtta gaacaattaa 1406161 atgaagctga agtgaaagtc attcgtgaat atcaaattga acgtgataaa atatacgcaa 1406221 aattaagaga gctggacaga aatggaagcc cttccgaaat caaaaaggat ttccgttctg 1406281 aaaaaaaacc tgactctctg ccggttctcg ctgagcttgc ggctcaggaa atcagaagct 1406341 atcagccgca atcacagcag cagtctgttc agcctcagct tcaatctatt tcctctcttc 1406401 ctgccggtat accagacgga acaacacgaa gaagaagagg aacggcaaga ccgggatcaa 1406461 aagcagctaa gctgcgtgaa gctgctatta aaacattaaa acgccacaac gcggcgatta 1406521 agagctcgga gcttcaaaaa gagattgaaa aagaaagcgg tcttgaaatc cctaatatga 1406581 caacgtttat gcaaagctta attaaaatgt acccggaagt gaaaaagcca tatcgcgggc 1406641 agtacatttt agagggtgaa atcgaatctg cagaatcagc aaacgaataa atataaagaa 1406701 aaactgcttg gcatcgctca agcagttttt ttattgaggt tttttctgtg aaggtttgtt 1406761 ttctttttca agattaagct tatacaccca cttttgataa ggcttttctt cagcggctct 1406821 gtttttcagc tcttcgattg tatggctctt ggcctggtct gatgattggg cgtgggcaag 1406881 ctgtttttga agcacatgta tctgtttggt gacatcttca aggatagtct ctacatgatt 1406941 tggctgcgcg taggccgctg gagcttcttc ttccgttttt tctttttgtt tcgtgccgcc 1407001 atcaatatcg gcaaaatgag aagcaatcca ggcatcgctt tcatcaagtt gccgtttata 1407061 cgatataata gtttcgtgaa ataatttttc tttcgttttt tctatgtcta gcagtctttc 1407121 tttcgtttct atgattcgat ctttcatatg atcaacttct attttaatat gttttagctg 1407181 atattctttt tctaccattt gctcttttag acgcccgttt tcggctttta tcaattcggc 1407241 ttgctgtttt gcctgaagca gtgcattttg ttcctgctca attgaggctt gaagttcgct 1407301 gatccgttta tgaagatttt tattttcttc ttcgattttg actttcgcaa tatgaagttt 1407361 atgtttttct tcgatttcgg ctctgcgttt ataggtttca gcagatagaa gctcctgcaa 1407421 aacaacgatt ttatcaagca gttcagctct tatttggtgc agggtttggc tggtgtggga 1407481 ggcatgtttt tcttttgttg acatatgtgt taattcggca gacagctgct ggagtttttc 1407541 tttcatatcg gtattttctt tgagcagttt gttatttttc tgatgaaagt agcttgcttc 1407601 aagttcagaa atcagcttat ggcaccttga aagctcggat tttaaataaa ggttctcctg 1407661 agacacgtcg tggaaaaaag gacctgatct tttcattcga accatctccc tcatgatgtt 1407721 aacactacaa tatgcaaata ctgaacagct attcctcttt aataaacaga caagcagtag 1407781 cgttgagcct ttgcttttgc tatgctttta acgaaactag aggtgagatg atatgaagca 1407841 tgtaaacgta ctgctggcag ggggagcctc acgtcgcttt ggagaaccga aggcgtttgt 1407901 caaatggaag ggcaggatgc tttacgaatg cgctaaagag gcacttggag aacaaacggt 1407961 tatcatcagc cgtcccgaat ttattgatag atttcaagaa aacggtgaaa atgaagtgta 1408021 tcaagatgct gagccatttc aaggcatggg gccattggct ggtatatata ccgcttttaa 1408081 aaagacagac ggtgatcttt atactgttct ttcctgtgac acaccgctga tacaaagaag 1408141 gacgatgctg gagctcaaac gtctgatgat tgccggtgcg gacgcggtag tcccaatttc 1408201 agacggacaa gtgcagccat tgattgcgat ttaccacaaa cgtatcatgc cagttctata 1408261 cgatcagctt tctgagaaga ggttgagaat atcagattta ttaggcagaa tttcggtttg 1408321 ttacgtacag gctgaaaata tcggagcaaa cccggcagag tttatcaaca ttaatacacg 1408381 tgatgatttt agctgtttgg aagaaaaatc gaactccctc aagcgggact gacggggcaa 1408441 taacatgata agatgacata aaagataagg agaacaggtt tgatggagga acgttattca 1408501 cggcaaatca gatttaagca aattggggaa gagggccaga aaagactggc agacagccat 1408561 gtgctgattg tcggagcggg agcgctcggc actgcaggag ctgaagggct ttcgagagcg 1408621 ggagtcggta cgattaccat tattgaccgt gactatgtgg agtggagcaa tcttcaaagg 1408681 cagcagcttt atacagaaag cgatgccaaa ctccgcatgc cgaaagccat ggctgccaaa 1408741 gagcatctat cagcgattaa cagcgagata catattgagg cgtatgttac cgaaggaaca 1408801 gccgaaacgc ttgagccgct gattgaaaaa gcagatgtcg tgatcgacgc gacagataat 1408861 tttgaaaccc gcatgctgat aaacgatctt gcccagaaaa caaagacacc ttgggtctat 1408921 ggcgcctgtg taagcagcca gggaatgttc atgactgtca ttcccggaga aaccccttgt 1408981 ctgtcttgtt tgtttgagca aattcctgtc ggcggggcga cgtgtgatac tgccggcatt 1409041 attccgcctg ctgtgcatat cgtttcagca tatcagcagg ctgaggcatt aaagctgtta 1409101 accggccaaa aagaagcaat acagcggggg tttgtgacat ttgatgtctg gaacaattcg 1409161 catatgaaga ttaacgttaa tcatgtacgc cgtgaggaat gcccatcttg cggagctaat 1409221 gcggtatatc cttatcttca ggattggaac acaccaaaag ctgctgtact atgcggccgt 1409281 gatacagtgc aggtaaggtc agaatcatta aaaagaatcc cgaaacagga gctcattaag 1409341 cggctgaaaa caatcggcaa ggtcgaggct aatgcgtttt tgctgcatat tttttacgag 1409401 gatttcagaa ttgtcatttt caatgacgga cgggcactgg tgcatggaac aaatgatgtg 1409461 aaagaagcca actccgtgtt ggcaagagtg attggactgt aacaacagga ggggtcagaa 1409521 tgctggagaa aagaacaccg ataccggtag acgaggcagt tcggcgtgtc tgccattttc 1409581 aaaaacaagg tgaaacagaa tgggtggcgc ttgaagacag ccttcatcgg tttttagccg 1409641 aagatataac tgcggatcac cacgtacctg cgtttgaccg ttcgccatac gatggttttg 1409701 ctgtcagagc gtgcgatacg gcagaagctt cacgtgaaaa cccagttcgg tttgaagtta 1409761 ttgaccatat tggagcggga gcagtatctg aaaaagaact tggcccgttt caggccgtgc 1409821 ggattatgac tggcgcgcaa atccctgaag gggcagatgc agtcgtcatg attgaactga 1409881 ctcaagcctt tgaggagaat gggaagtcat ttatgtcttt aaaacgccgc tttcagacgg 1409941 gggataatat ttcaaaaaca ggtgaggacg ctcaaaaagg gagtgtttta ctgacaaagg 1410001 gcacccgggt gacaccagga gtgacggctc ttttggcaac attcggatac gcatctgtgc 1410061 ctgtcgtgag aaagcctgta gtcgggatta tcgcaaccgg taccgaattg ctgaatgtca 1410121 gtgatccgct ggaaccggga aaaatccgca acagcaatgc gagtatggta tatgcgcaag 1410181 cgatagaagc aggcgcaaca ccgctttatt tagggaaaat ctctgatgaa ctggataaaa 1410241 gctttgctgc agttaaagaa gcgatgaaaa aggtggactt cctgatcaca actggcggtg 1410301 tgtcagtcgg tgactttgac tttttgcctg cgatctatga aaaactcgga gcggacgtgc 1410361 tgtttaataa agttgccatg cgcccgggca gcgtgacaac ggtggcgcat gcaaacgata 1410421 tgctgctgtt tggcctttca ggtaatccgt cggcatgcta tgtcggtttt gaactgtttg 1410481 tcaaaccgat aatccagaca tggctgctca atgaaacacc gcattcaatt tgtgcggaag 1410541 ctgttttgac caaggatttt ccgaagccga acccatttac ccgatttgtt cgtgcgctcg 1410601 tgcaccatca ggaagggaag ctgttggcga cacccgttgg cttagataag tcgagctctg 1410661 tcacatcact tgcagatgcc aatgcattta ttatcctgcc gggcggtacg cgaggctacg 1410721 aatctggcag aacggttcaa gtgctgctca tcagagaaga gaatggaagt gaatggcctt 1410781 ggtccgtcct ttcccgatcg tccaagttgt aggatttcaa aacagcggga aaacaacgtt 1410841 tattgagcgc attcttgaaa aagcctctga acagggagtc catttgggct gcctgaagca 1410901 ccatggtcac ggcggtgaac cgcaaacgct cacggaagga aaagacacgg accgttacaa 1410961 ggcggcaggt gctgatgtaa cagcggtaga aggtgctggt gtgttacagc tgactgcccg 1411021 ccgcaattgg gatttggcac ggctgattga gttataccaa tttctcgaaa cagactgtct 1411081 tctgattgaa ggctttaaaa aagcccctta tcctaaagtg gttatcctaa gtgaaaagga 1411141 agatctggaa gcgctgcaag cagtaaatat aatcgccatc atctatagaa aaaaagagca 1411201 tatgacagag catcagggat tacccgtttt tcatgcggat gatccggttg ccgtggattt 1411261 tgtgctttca cagctgaagg gggaatctgc ataatggaac ggtttgagat tacgaaaaca 1411321 cccattaata ctgaaaacat catcaaaaaa gtggagaaac gggaagcggg agccattaca 1411381 acatttattg gtacggttcg ggaatggaca aacggaaaaa gaacggttcg gcttgaatat 1411441 gaggcatatg aaccgatggc cgtgcaaatg cttgctcaaa tcggcgctga aatcgaagaa 1411501 aaatgggaag gtgcctcagc tgcgatcacg caccgtatag gtgtgctcga tatcggtgaa 1411561 gcagcggtag tgattgctgt atcttctccc catcgaaaag ccgcatatga agccaatgag 1411621 tatgcgattg aacgcattaa acagattgtg ccgatttgga aaaaagaaat ttgggaagac 1411681 ggtgagcaat ggatcggcga ccagctagaa acgacagctt atccgaacgg aaaaccagac 1411741 ctaagcgagg gagagcagca tgattaaaat tcttttattt gcagggcttg ctgaacaggc 1411801 cggtacacaa gcaatagaaa tagatatgga acaagcaacc acagatgaaa taaaagcgag 1411861 tctaaaagaa caatacggtc ttgaatctat tgatacggct atgattgccg ttaacgaaag 1411921 ctatgtaaaa gaaaatacct ctgtatcttc gggtgacacg gtagccatca taccgccggt 1411981 cagcggggga tgaaaaccgg acggcatttc agccgtccgg tttttctgta tttcattggc 1412041 atatccccaa gtatcctcag catacaatga ttttctgtaa gcgtttattc tacatatgtt 1412101 actccctata aagtaagaga ctcactccat aattagactg aaattttgaa aaataataga 1412161 aatttatttc gggtatcgat atagtgaaga tgataaatgt tggaaaggtg ctggatatgg 1412221 agacatttaa aagattaaaa atgtattatt ggccgtacag aaaagtgttt atgtggtcgc 1412281 ttctagccat gcttttgatg actgcaatta ctgtcgttta tccgattatc ctgcaaatta 1412341 cgattgatga gatcgtactg ggacggcagt atcagcttgc ggcgtgggtc agcttaggat 1412401 ttattgcggt gatggttttg aaaggaatgg ctaccttttt tcatcagtat ttaggtgata 1412461 tgttcgggat caaatccgtt tatcggctga gaaatggtct gtatgaaaaa ctgcagcggc 1412521 tttctttttc ttactatgat aacgcgaaaa caggagattt gatgtccagg ctgactgctg 1412581 atgttgaagg gcttcgtttt ttcttatcat acggtctcgc tgagctcatt cgcttcggcc 1412641 tgctggtagc catcagcctg tcggttatgt tttactattc tgttcctctc acgcttgtga 1412701 caatagctgt tctgccattt ctcgcggttg cggtataccg gtttgacaaa agagtccatc 1412761 ccgccttcag aggcatccgc aaatcgtttg cgaaactcaa tacaaaagtt caggaaaata 1412821 tcagcggcat taatacggtt aaatctcttt ccagggaaga ttttcagatc agcactttca 1412881 ataaagccaa tgcagaatac agggcgcagt atttacaaac atcatccatt tggtctgcgt 1412941 atttcccttt aatggagttc attggtaaca cttgtattgt agctcttctc tcatacggcg 1413001 gttacttggt tatgcaaaat cagctcaatc ccggcgagct tgttgctttc ttcagccttg 1413061 tcaattatat gatgtggccc attatgaact taggttttgt catcaatatg ttctctcaag 1413121 caaaagcgtc aggggaacgc ctgctcgaca ttctggaaaa agaagaagac attacagatc 1413181 atcctcatgc tttgcataaa caaaaattaa ccggagatgt ccatttcaaa aatgtttctc 1413241 ttgcatacgg aaaagaacaa acaaacgcgc tgtgcaatgt aagctttgag gcaaacagcg 1413301 ggaaggtaat cggactgttg ggcccgacag gttcaggcaa aagctcagtg acacagcttc 1413361 tcaccagatt ttacagtcct gttggcggaa tgattaccat tgatcacaaa cccatcacag 1413421 attattcgtt aaaaaccctt cgctccaata tcggggtcgt acttcaagaa tccttcctgt 1413481 tttcatctac gattagatca aatatttcgt atgggcggcc ggatgcctca atggaagacg 1413541 tcatcgaagc ggcaaaaagg gcgcaggctc ataactttat tatggagctt cctgatgggt 1413601 atgacaccat gctgggagag aggggaatgg ggctttccgg cgggcagaaa cagcgtattg 1413661 ccattgcgag agccatctgc ttgaacccga gcattttaat attggatgat gccacaagcg 1413721 cagtagatat gcaaacggag cacagcatac agcttgcctt aaaagaagtc atgaaaaacc 1413781 gcacaacctt tatcgtcgct caccgcattt cttcactgaa acacgctgat gaaattctcg 1413841 tttttaataa aggacgcatt cgtgaaaggg gaacacatca tgagcttctt gaaaaaggcg 1413901 gctactataa aaagatttac gatttgcaat accgtgatgt caaaatgatt aatgagccgc 1413961 atgaggtcgg atagggaggg gccaaatgaa acaagcgaaa aaacaggggg ttttagagcg 1414021 tttctattac tcttcagatg aaatcattga aaagccgttt aactgggctc aaatgtggcg 1414081 gctgctgagc tatgtcaaac catatcgaaa aacaattttg ccgctttctt ttctcactgt 1414141 attgattggc actgctgtga agcttgtgat ccccattttg atcggcgttt atgttcttga 1414201 tcaagcgatt acagggagaa actcggagct gctgattcag ctcattttta ttattagcgg 1414261 tttatatgtc ctcaattacg ccgccaatgt gttaagaatc aggtggatga atcagcttgg 1414321 ccagcatgtc atttacgatt tgcgacagca tttatttacc catgtgcagc gcttatccca 1414381 tcgatttttt gatcagcggt cggcgggatc gatcttagtc aggatcatga atgatattaa 1414441 ctctcttcag gagctcttta caagcggagt catcaatttg ttgaccgact tgctgcttct 1414501 ggccggcgtg attattattt tgtttacgct gagccctgag ctgactatag ccatcatggt 1414561 gacattgccg attatgtttt ttatttcaac aagtctcaga aaaaaaatac gccgatcctg 1414621 gcaaacggta cggctgaagc aatcgaagct caactctcat ctaaacgaaa gcattcaggg 1414681 catccgggtc acgcaggcat ttacgcagga agaagaaaac atggcgtatt ttgacggtgt 1414741 caatcaggag aactacgaat catggcggga agcaactaga aaaaatgcca tgttccgtcc 1414801 gcttgtagaa atgacgaatg cgattgggac ggctgtcttg atttggtatg gagccacact 1414861 catcatgaat gaaaccatta cgattggcgt cttcgtttct tttgctttct atctgggaat 1414921 gttttgggaa cctatttcga gactgggtca ggtctataat cagctgttaa tggggatggc 1414981 atcatcagaa cggatttttg agtttctgga cgaacagcca aatgtcaagg agaagccgaa 1415041 tgccattcat aatgaaaaga taaatgggga gatcagtttt gaagaggttg aattttcgta 1415101 tgatgaaaaa cgaaaagccc ttcacgccgt ttctttctct attcctgcgg gatcgacgct 1415161 tgcgcttgtc gggcatacag ggagcgggaa gacgacgatt gccaatttaa tcagccgttt 1415221 ttatgatgcg gccggaggca ccattaaaat agacggtata ccgattaagg atctttccct 1415281 tgccagtctg cgctctcaaa tcagcattgt cctgcaagat acatttattt tctccgggac 1415341 catcatggaa aatattcgtt ttggaaggcc aaatgcttcg gatgaagagg tgatgaaagc 1415401 gtcccaagcg gtcggagcgg atgagtttat ttccgattta gcggaaggat acgcaacaga 1415461 ggtagaggaa aggggcagcg tactgtctgc cggtcagcgc cagctcattt catttgcaag 1415521 agcattgctc gccgatccgg ctattatcat ccttgacgaa gcaacggcaa gcattgatac 1415581 agagacagaa gtaaaaattc agcaagcgtt aaaaacgctt ctgaaagggc gtacagcagt 1415641 gatgatcgct cacagattgt ctacgatccg cgacgccgac cgcatcattg ttcttgatca 1415701 cggcaggaaa atagaagaag ggaaccatga tcagctgctc gctaaaggag gcatttatgc 1415761 cgggcttgtg aaagcgcaat acagcacagc gatagaataa tatgaaaagc cttcaatatt 1415821 gaaggttttt ggaaatttat tagaaaaaca tgaaactttt tgatatcctt cccgtactat 1415881 ttgttagata ttctcaagga ggttttgaaa tggaaacgaa tgtagaaaaa aacagcggaa 1415941 cggcgactga aaagccttca cttttcggag taatcacaag tccgtccgtt caatttgaaa 1416001 gaataagaga aaggccggct gtatggggac cgcttttgat tgttgcagca attatcatcg 1416061 tcggtgccgt gctgcaatca ctcggtacgg attatagtga gcttttgaaa agccaggata 1416121 cgcaagggct atctgctgaa caaatggaaa ctgtcgcaac aataaccaaa tttggcggaa 1416181 tggcaggcgc tattatcggc ggtatcgcag cattatttat tgcccctctt atttattggc 1416241 tctgtgtaaa agtatcaggc ggtgttacga catataaaaa aatgctttct ctcagtctgt 1416301 ttgtctcttt gattagcagt ctcggattat tggttaatgg aatcgttgct tttacgactg 1416361 acgtgaatcc tctttacagc acgacgtcac tcgcagggat tatcccatct gacggggctc 1416421 tcgccagtgt gttaaatacc tttgaaattt tcagcatctg gagctttgta ttattagcaa 1416481 tcggacttca caaaacggga ggcatctcaa aaaaagccgg gtggatttca gcaatcattc 1416541 tattcggaat tttagttgta ttttcgcttt tttcaggttt aatcaattct gtggcgggtg 1416601 cataagctca tgaaaaaagt ctggatcgga attggaatcg cagttatagt cgctcttttt 1416661 gttggaatca atatataccg gtctgccgct ccgacaagcg gcagcgccgg caaggaggta 1416721 cagacgggga gcgttgaaga aaatgaaatc tcatcaacgg ttatggttcc tggcacgcta 1416781 aaattttcaa atgaacagta tgtcttttat gaagcggata aagggacatt agaagacatt 1416841 aaagtaaagg aaggcgataa agttaaaaag ggcacggctt tagtcaccta tacaaatgag 1416901 cagctgagcc tggaaaaaga acagaaccag ttaacgtctg aatccaaccg gcttcaaatt 1416961 gaccaaattc aagaaaagtt aaaagccttg gacagcaaag aaagagaact ggaaaaacag 1417021 gtaggaaaga aagaagcaga aaaacaaatc gaatctgaac ggacagagct tcaaatgcag 1417081 aaaaaaacag cggagatcga attaaaacaa accgagcttc agcggcagtc acttgccaac 1417141 cgggtgtcag atttagaagt gaaaagcgaa attgaaggca ccgttatttc tgtcaaccaa 1417201 gaagcggcat ccaaaaagtc agatattcaa gagcctgtca tacatatcgg caacccaaaa 1417261 gaccttgtcg tctcagggaa attgtctgaa tacgatacat tgaaagtcaa aaaaggccag 1417321 aaggtcacac tcacttcaga tgtaatacag ggtaaaacat ggaaaggcac ggtttccgca 1417381 gtcgggcttg ttccggatca gcaggagagc gctgcggcac aaggaacaga acaggcggtc 1417441 caatacccgc ttcaagtgaa aataaaagga aatcttccag aaggaaagcc aggctttaaa 1417501 tttatcatga atattgaaac agataaacgg aaagcaaata cgcttccttc aaaggcagtc 1417561 aaaaaagaag atgaccaata ttatgtgtat acagtaaaag acggaaaagc aaagcgagtt 1417621 gatgtcaaaa tcggcgaagt gacagatgac ctgacagaaa ttaaagaggg gcttacccaa 1417681 gatgatcaag tcattttgaa tccatctgat caggtgactg acggaatgga agtgaaatcc 1417741 taaatgattc agctttctaa tgtgcgaaaa agctaccaga tcggaaagga aacgtttgat 1417801 gttctccatt ctattgattt ggacattcat caaggtgaat atgtctcgat tatggggccg 1417861 tcaggatcag gaaaatcgac gatcatgaat attatcggct gtcttgatcg gccgacttcc 1417921 ggtacatatc aattggacgg cgaagacatt tcttcatata aagataaaga actggcggca 1417981 gtccgtaacc ggtccatcgg ttttgtattt cagcaatttc agcttcttcc gcggctgaac 1418041 gcaaaaaaaa atgtcgagct gccgatgatt tattccggga taggcaaaaa ggaacgtcaa 1418101 gagcgggctg agagagcatt ggaaaaggtc gggttagccg atcgaatgct ccacatgccc 1418161 aacgagctgt cgggcgggca gaagcagcgg gtggcgattg cgagggcgat cgtgaatgag 1418221 ccgaaattga ttttagctga tgaaccgacc ggcgcgctgg atacgaaaac aagcgaggcg 1418281 attatggatc agtttacagc attaaatgcc gagggaacga caatcgttct ggttactcac 1418341 gagcctgaag tagcagattg cacgaatcgg atcgtcatgg tgcgtgacgg aaacattgtt 1418401 cctgccagct ccggacaaag gagtgtggga gaatgagcct gttggaaaac atcagaatgg 1418461 ctctaagctc tgtccttgcc cataaaatgc gttcgatctt aacgatgctc ggcattatca 1418521 ttggtgtagg ctctgtcatt gttgtcgttg cggtaggaca gggcggcgag caaatgctga 1418581 agcagtcgat cagcggcccg ggaaatactg tggagctgta ctatatgcct agcgacgagg 1418641 agcttgcaag caacccgaat gccgcagctg aatctacgtt tacagaaaac gatattaaag 1418701 gtttaaaagg aatagaaggc attaaacaag tcgttgcttc gacttctgaa agtatgaaag 1418761 cgcgttatca cgaagaagaa accgatgcta cggttaacgg aataaatgat ggatacatga 1418821 atgtcaattc tttgaaaatc gaaagcggca gaacctttac cgacaatgac tttctcgcgg 1418881 ggaatagagt cggaatcatc tctcaaaaaa tggctaaaga gctgtttgat aaaacctccc 1418941 ctctaggtga agttgtctgg attaacggac agcccgttga aattatcggc gtgctgaaaa 1419001 aagtaacagg cttgctttct ttcgatttaa gtgaaatgta tgtgccattt aatatgatga 1419061 aatcctcttt tggcacaagt gatttcagta acgtatcatt gcaggtcgaa tcagcagacg 1419121 acataaaatc ggctggaaaa gaagcggcac agctggtaaa tgacaatcat ggcacagagg 1419181 attcgtatca agtgatgaac atggaagaga ttgcggccgg aattggcaaa gtaactgcaa 1419241 ttatgacgac gattatcggc tcaattgcag gtatttccct tttggtcggc ggaatcggtg 1419301 tcatgaatat tatgctcgta tcagtcacag aacggacgcg ggaaatcgga atcagaaaat 1419361 cacttggtgc gacgagggga cagattctga ctcagttttt aattgaatca gtcgtattga 1419421 cgctgattgg cggtctggtc gggattggta ttggatacgg aggggccgcg cttgtttcag 1419481 ccattgcggg ctggccgtca ctcatatcct ggcaggttgt atgcgggggc gtgctgttca 1419541 gtatgctcat tggtgttatt ttcggcatgc ttcctgcaaa taaagccgca aagcttgatc 1419601 ccattgaagc gctgcgttat gagtagcctc atgcaacatg catgaggttt ttttatgttt 1419661 agtgatttct actatgaata taaaagactt ttttcattaa aataagaaga aaatgtcgta 1419721 caattgtcct tatttttgtc gaatttacag tttacaaacc ctatagacat acgttaatat 1419781 ggagaaacgt gaaagatttt gatagttatt gaatgaattt gaatgatttt agttgcctaa 1419841 accgaaaata gcgtttacaa tgaaattgta ttcaaaatga atacgttttc attaggaggt 1419901 gaagcatgct aactcctgaa cggcatcaat tgattattga tcaaatagaa aagcatgatg 1419961 tggtaaagat tcaagagctt ataaatctga ctaatgcttc tgaatcaaca atcagaagag 1420021 atttatcgac ccttgaagaa cgcggttttt taaagcgcgt tcatggtgga gcggccaagc 1420081 tttccgatat cagacttgaa cccgatatgc ttgaaaaatc atccaaaaac cttcacgata 1420141 aactgaagat tgctgaaaaa gctgcttctc ttttagaaga aggggattgc atttaccttg 1420201 atgcaggcac gacgacattg cacatgattg attttatgga taaaaccaaa gatattgtcg 1420261 ttgtcacaaa cggggtaatg catatcgatg cattaataag gaaagaaatt tctttttatc 1420321 tgcttggagg atacgtaaag cacagaacgg gcgcgattat tggaggcgct tcattggttg 1420381 ccatggacca gtacagattt gacaagagtt ttctggggac aaacggtgtc catacagagg 1420441 ctggatttac aacgccggac cctgatgagg cccttttaaa acagaaagcg atcaaacagg 1420501 caaaacacgc ttacgtctta gcagaccctt cgaagttcgg agaaatttca ttttcggcat 1420561 tcgccggaat aggcgacgca acaatcatta cgactgacgc tgaagagctt acattcgata 1420621 attaccaaga aaaaactgtc gtaaaggtag tgaaaccatg atttacactg taacacttaa 1420681 tccatctgtc gattatatag ttcacgttga agattttact gtaggaggcc tgaaccgttc 1420741 ttcgtatgat accaagtatc cagggggcaa aggcatcaac gtatcgagac tgctgaaaag 1420801 acaccatgtg gcgtctaaag cgctcggatt cgtcggcgga tttaccggag aatatatcaa 1420861 aacattttta cgggaagaaa acctggaaac agctttttct gaagtaaaag gggatacccg 1420921 tatcaatgta aagctgaaaa cgggtgatga aactgaaatt aacgggcagg gaccgacaat 1420981 ttcggatgaa gatttcaaag cctttttaga acagttccaa tctttgcaag agggagatat 1421041 cgttgttctt gcaggaagca ttccatcttc actccctcac gatacttatg aaaaaatcgc 1421101 agaggcctgc aaacagcaga acgcacgagt tgttctggat atctcaggcg aggctctttt 1421161 gaaagcaaca gaaatgaaac catttttgat gaagccaaat catcatgagc ttggagaaat 1421221 gttcggcacg gccattacat ctgttgagga agccgttcct tatgggaaaa agcttgtaga 1421281 acaaggcgct gaacatgtaa tcgtatcaat ggccggagac ggagcgcttc tgtttacgaa 1421341 cgaagctgtt tattttgcta acgtgccaaa ggggaaattg gtaaactcag tcggagcagg 1421401 ggattccgtt gttgcaggtt tccttgccgg aatttccaaa cagctgccgc ttgaagaagc 1421461 attccgctta ggagttactt caggcagtgc taccgcgttc tctgaagaac ttggaacaga 1421521 agaatttgtc cagcagcttc ttcctgaagt taaggtcaca cgtctataga ggaggaaaca 1421581 caagtgaaaa taactgagct tttaacgaag catacgataa agcttaatat tgagagcaaa 1421641 gaaaaagaaa atgttattga cgaaatggtc actgttcttg ataaggctgg aaagttaaat 1421701 gaccgacaag cctataaaga agccatttta aatcgcgaaa gccaaagctc cacgggtatc 1421761 ggtgaaggaa tcgctatccc ccatgcgaaa acggcaagcg ttatcaaccc ggcgatcgcg 1421821 ttcggacgtt caaaagacgg cgtcgattat gaatcattag acggccagcc ggctcactta 1421881 gtgttcatga tcgcggcgac tgaaggcgca aacaacactc accttgaagc attgtcaaga 1421941 ctttcaacgc tgttaatgcg tgaagaaatc cgtaagcagc tccttgaagc tgagtctgaa 1422001 gatgccatca tcgacattat taatcagcac gataaagatg atgacgaaga ggaagaggaa 1422061 gaagaagcgg caccagcacc tgccggaaaa gggaaaattt tagcggttac tgcatgcccg 1422121 acaggtattg cccatacatt catggctgcg gatgccctta aagaaaaagc gaaagagctt 1422181 ggtgtggaaa ttaaggtcga aacaaatggg tcaagcggca ttaagcacaa gctcactgcc 1422241 caagaaatcg aagatgcacc tgcaatcatt gtcgcagcgg acaagcaggt tgaaatggaa 1422301 cgttttaaag gcaagcgcgt acttcaagtt cctgtaacgg cgggtatcag acgtccgcaa 1422361 gagcttatcg aaaaagcgat gaatcaagat gcgccgattt atcaaggcag cggcggcggt 1422421 tcagcagctt caaatgatga tgaagaagcg aaaggcaagt ctggaagcgg tatcggaaac 1422481 acgttttata agcacctgat gagcggtgtc agcaacatgc ttccgttcgt agtcggcggc 1422541 ggtattctcg ttgcgatttc attcttctgg ggaattcact ctgctgatcc gaatgatcct 1422601 agctacaaca cgtttgcagc agcattaaac tttatcggcg gcgacaatgc attaaaactc 1422661 attgttgcag ttctggccgg tttcattgcg atgagtattg cagatcgtcc tggttttgcg 1422721 cctggtatgg tcggcggatt tatggcaact caagcgaatg ctggattctt aggcggctta 1422781 attgccggat tccttgccgg ttatgtcgtg attttactga aaaaagtatt tacgtttatc 1422841 cctcagtcac ttgatggatt aaaacctgtt ttgatttacc cgctgttcgg tatttttatc 1422901 actggcgtat taatgcaatt tgtcgtcaat acacctgtag cggcatttat gaatttctta 1422961 acaaactggc ttgaaagcct tggtactgga aaccttgtgt taatgggtat tatcttgggc 1423021 ggcatgatgg cgatcgatat gggcggtccg cttaataaag cagcctttac gttcggtatc 1423081 gccatgatcg atgcaggcaa ctatgcgcct catgcagcaa tcatggccgg cggtatggtt 1423141 cctccgcttg gtatcgcact tgcaacaacc attttcagaa acaaattcac tcagcgtgac 1423201 cgtgaagctg gtattacatg ctatttcatg ggagctgctt tcgtaacaga gggagcgatc 1423261 ccatttgctg cggctgatcc gcttcgcgtc ataccagctg ctgtagtcgg tgcagctgtt 1423321 gccggcggat taactgaatt cttccgagta acgcttccgg cgcctcatgg aggagtattc 1423381 gtagctttca ttacaaacca tccgatgctt taccttttaa gtatcgtgat cggtgctgtc 1423441 gtgatggcaa ttatcctcgg tatcgtcaaa aaacctgtta cagaaaaata agaaaaaaag 1423501 cgtccttggt tcgaaaggac gctttttctt atccggccgg cagggagcgc ggttaagtta 1423561 tgtattttat tcttttttat gataaagtaa aagaagagaa acaactgaca tagcaattgt 1423621 ctaggaggaa acactttgac cgaggaaaaa aatacgaata ctgagaaaac ggcgaagaaa 1423681 aaaaccaata cgtacctgga atggggtaaa gcgattgtca tcgctgttct gctggctctc 1423741 ctgatccgtc actttttgtt tgaaccgtat ttagttgaag gttcatctat gtatcccaca 1423801 ttacatgacg gagaaaggct gtttgtgaat aaaacagtca actatatcgg cgagctgaag 1423861 cgcggagata tcgttattat caacggtgaa acttctaaaa tccattatgt aaaaagattg 1423921 atcggaaagc ctggagaaac cgttcaaatg aaggatgaca cgctttatat aaacggtaaa 1423981 aaagtagccg agccttactt gtctaaaaac aagaaggaag cagaaaaact tggtgtcagt 1424041 ctgacaggag actttggacc ggttaaggtt ccgaaaggca aatactttgt catgggagat 1424101 aaccggctga attctatgga cagccgaaac gggctgggac tgatcgcgga agatcgaatt 1424161 gtcggcacat cgaagtttgt ctttttcccg tttaacgaaa tgcgtcaaac aaaataaaaa 1424221 cgccttgctg gcctaggaca gcaggcgttt ttattttgaa aaagaagcga ccaatgcaat 1424281 gcataaaacc gtgatgaaca ctgaaccgat aatagccagc acactgaaga aaaggtgaac 1424341 ctgtttgttc tcttttccgc gcttttctaa tagccgttta gaaaaaatgt gcgaaaatat 1424401 gtaaataagg gctatgccta tatataagcc gatatctttg gcggtaaagc ctgttacggc 1424461 aaggtaaaag cccgtaaaaa agatcagtaa gcaatattca gtaagtgtta aaagcctcaa 1424521 cgtgttcctc catgagagtg tgtaattttc caggcggatg cattctctct ctttaattgt 1424581 aacacagctg gctggtttgg gtgtataagt gttttctctc tgttttatca gggaatcatt 1424641 tctcttgccc tgcattcatg gtatactttt attgatgata gacatgatgg aggataataa 1424701 atgattgctg taaataatgt aagcttgcgg tttgcggatc gcaagttatt tgaagatgtt 1424761 aatattaaat ttaccccagg caactgctat gggttaattg gtgcaaacgg tgccggtaaa 1424821 tcaacgtttc taaaggtgct gtcaggcgaa atcgagcctc agacaggcga cgtgcatatg 1424881 agtcctggcg agcgtcttgc cgtcttgaag cagaaccatt ttgagtacga agagtatgaa 1424941 gtgctgaaag tggtcattat gggccacaaa cgcctgtatg aagtcatgca ggagaaagac 1425001 gctatttaca tgaagcctga tttctcagat gaggatggga ttcgtgctgc tgagctagaa 1425061 ggtgaattcg cggaactgaa cggttgggaa gcggaaagtg aagctgcgat cctgttaaaa 1425121 ggccttggta tctcagaaga tctgcacaca aaaaagatgg cagacctcgg cggttcggag 1425181 aaggtaaaag ttctcttggc acaggcatta ttcggcaagc cggatgttct gctgctcgat 1425241 gagccgacga accacctgga ccttcaggca attcagtggc ttgaagagtt tctgattaac 1425301 tttgaaaaca cagttattgt cgtatcccat gaccgtcact ttttaaataa agtatgtacg 1425361 cacattgccg accttgattt taacaaaatt caaatctatg tcggaaacta tgatttctgg 1425421 tacgagtcaa gccagctggc gttaaagctt tctcaagaag cgaacaagaa aaaagaagag 1425481 cagattaaac agcttcaaga gtttgtcgct agattcagcg ccaatgcgtc taaatctaag 1425541 caggctacat caagaaagaa acttctcgaa aaaatcacgc tggatgatat taaaccgtct 1425601 tcccgccgct atccttatgt taacttcacg ccggaacggg aaatcggaaa tgatgttctt 1425661 cgcgtggaag gcttaacaaa aacaatcgat ggcgtaaagg tgcttgacaa tgtcagcttt 1425721 attatgaatc gagaagataa aattgctttc actggccgaa atgaacttgc tgttactacg 1425781 ctgtttaaaa tcatttccgg ggaaatggaa gctgacagcg gaacgtttaa atggggtgtt 1425841 accacatctc aagcgtattt tccaaaagac aacagcgaat atttcgaagg cagtgatctg 1425901 aaccttgtag actggcttcg ccaatattct ccgcacgacc aaagtgagag ctttttacgc 1425961 ggtttcttag gacgcatgct gttctctgga gaagaagtcc acaaaaaagc aaatgtactt 1426021 tccgggggag aaaaggtccg ctgtatgctg tcgaaagcga tgctttctgg cgccaatatt 1426081 ttaattttgg atgagccgac caaccattta gacctagagt ccattacagc gctcaataac 1426141 ggcttaatca gctttaaagg cgctatgctg tttacttccc atgaccatca gtttgtgcag 1426201 accattgcca acagaattat agaaattaca cctaacggca tcgtcgataa gcaaatgagc 1426261 tatgacgagt tccttgaaaa tgctgatgtg cagaaaaaat tgactgaact atacgccgaa 1426321 taaaaaagca gagatttctc tgcttttttt gatacctaaa tgtgaaagga gatcacaaca 1426381 tgaaattttt ggttgtcgga gcaggtggag taggcgggta tattggcgga cggctttcgg 1426441 agaaaggaaa tgatgtgaca tttctcgtgc gccaaaaacg agctgagcag cttaaaaaaa 1426501 ccgggcttgt catccatagt gaaaaaggga atgtatcatt tcagcccgaa ctaatcagtg 1426561 ccggagaaac agggcaattt gatgtcgtta tcattgcttc taaagcatac tcgcttggtc 1426621 aagtgataga ggatgtcaaa ccatttatcc atcaagaatc tgtcattatc ccttttttaa 1426681 atgggtaccg ccactatgag cagctatttg cggcattttc aaaagaacag gtgctgggcg 1426741 gcctgtgttt tatagaaagt gctttagaca acaaaggaga aattcatcat acgagcgcat 1426801 cgcatcgttt tgtatttgga gaatggaacg gcgagcgtac ggagcggata agagcgcttg 1426861 aagaggcatt ttcaggtgtg aaggctgaag tcatcattag cgggcatatc gagaaggaca 1426921 tttggaaaaa gtatctcttt attgcagcgc aagcggggat cacaacgtta tttcaacgac 1426981 cgcttggccc aatcctcgcc acagaagccg gacgtcacac ggcccaaact cttattgggg 1427041 aaatttgcac tgttttacga aaagaaggtg ttccggctga tccggctctt gaggaagaga 1427101 gctttcgtac gatgaccagc atgtcttacc atatgaagtc ctccatgctt cgggatatgg 1427161 aaaacggcca aacgacagaa ggcgaccacc tgcatggatt tttgattgaa aaagcaaaac 1427221 gtttatctct cgctgcacca gtattagaaa ccgtttatgc gaatctgcaa atgtatgaag 1427281 cagaaaaata aaaaaaggag gcggaaaagc ctccttttat ttacttaaaa agcccaattt 1427341 ccgtttctga agataggctc tcttttcccg tctgccgtaa ttccgtcaat attcatatcc 1427401 ttagaaccga tcataaagtc cacgtgtgta atgctttcat ttaggccttc tttgacaagc 1427461 tcttcacgag acatctgctt tccgccttca atattaaagg cataggcgct tccgatcgcc 1427521 aaatgatttg acgcgttttc atcaaacagc gtgttataga aaagaatgtt tgattgtgat 1427581 ataggcgaat cgtaaggaac aagtgccact tcacctaaat agtgagaacc ttcatctgtt 1427641 tccaccagtt cttttaaaat atcctcacct ttttcagctt taatgtcgac tatacggcca 1427701 ttttcaaacg tcagggtgaa attttcaata atatttccgc cgtagcttaa tggttttgtg 1427761 cttgatacca ctccgtcaac cccgtctttt tgcggcagcg tgaacacttc ttctgtcggc 1427821 atattggcca taaactcatg gccactttca ttcacgcttc ccgcacctgc ccaaacatgc 1427881 ttcctaggca gcttaattgt tagatcagtt ccttctgctt gataatgtaa ggcagcgtaa 1427941 tgtctctcgt tcaaatggtc aactttttca tgaagatttt ggtcatgatt gatccacgcc 1428001 tgaaccgggt tgtcttcatt tacgcgcgtc gctttaaaaa tttcttccca cagaaggtgg 1428061 atcgcttcct cctctgattt gccaggaaac accttgtgag cccagcctgc tgatgccgca 1428121 cctacgacag tccagctgac tttgtctgat tgaatatatt gtctgtatgt atgtaatgct 1428181 ttgcctgctg ctttttggaa tgccgcaatc cgtttggaat ctataccttt tagcaagtct 1428241 gggttcgacg acacaacaga aatgaaagca gctccatttt tggcaagctc ttctctgcct 1428301 tttgcttccc attcaggata ttcttcaaat gcttcaaacg gcgcaagttc gtattttaat 1428361 ttggcgactt cgtcatcctg ccaattcacg gtgacgtttt ttgcgccctt ttcatatgcg 1428421 tgttttacaa ttaaacggac aaaatcccga acgtctgttg aagcatttac gactacatac 1428481 tggccttttt ggacattaac gccgacttct accgccagct gtgcatatgt atttaatttc 1428541 tgtgaaaatg aatccatgaa tcattcctcc aagctttttt ctcatcatat caaatatgat 1428601 cctataaagg aaagaaggag cccaaagtga aaaacccaaa acgacacgtc ttgggttttt 1428661 tcaatattat ggatgattca gttttacagt gccgcctgca ggcgaatggg gcatatttgc 1428721 caaagaaatg ctcatgcctc caagaataat tccgcttaaa atggctgcga tcgctactct 1428781 tcttcctaaa tctcttagca tctgtttcct ccttaacgtt tctccatttc ccacaatatg 1428841 aaggaagtga ggaaaaaaga agcaagaaat ttgccgcgtg tgagaatttt gcgggtaaag 1428901 actatttaat tgccttttgc agcttatcaa tcacttctaa agaacggcct gtgccgattg 1428961 ctacagattc aagcgggttt tgcgccacgt gtacaggcac gacaatctct tctgtgagcc 1429021 attctttaat tccattaagg agcgcgccgc cgcctgttaa aataacgccg cgatcaacaa 1429081 tatctccgct caattcaggc ggacagtcct caagtgtcgc tctgatggct tcaagaatat 1429141 gcaggaggga ttcacgcatt gcatcttgaa tttcgttgga ttgaagcata atggtttttg 1429201 gaagacctgt cacgaggtca cgtccccgaa tttccattgc ctctggtata tgttcaatca 1429261 gagcatggcc aatttccatt tttacctgct cagctgtgcg ttcgccgatc agcaaattgt 1429321 attttttacg gacgaaagaa acgatatcct catcaagctg gtctccgccg atcctgatag 1429381 aatggcagga aacaacgcca ccgaaggaaa taatagcgac ctctgtcgtc cctccgccga 1429441 tatctactac cacattggca accggctcat caaccggtaa atccgctccg atggcggctg 1429501 caactggctc ttcgattaaa tgaacgtttt tcgcgccgca atttttcacc gcatcactga 1429561 tggcgcggcg ttctactgct gttgagcctg atggtgtgca aacgactacg ttcggttttc 1429621 tgaacgacat gccgatgctt tttgcggctt ttttcataat gtgctttagc aggtcagttg 1429681 tcatatcata gtctgcgatc acgccatctt tcatcggtct gacagcgaca atttttcccg 1429741 gtgttttacc gatcatgttt ttcgcgtcag ctccgattgc aagcactgct tttgtcgtcg 1429801 tatccactgc gacaacagat ggttcattta ggataatccc tttatttttg ctgtaaacaa 1429861 gtatattagc tgttcctaag tcaatcccga tttcagttga ttgaaacatg ttttcaccca 1429921 atctctatcc taatttaata tgattctaca tttaaagttt ctcagaaata ctgcgatttt 1429981 tgggggtgtg cgtcggtaaa gaaatgtttt tgtaaaaaat caaggaactg tgtaacagaa 1430041 gtaatacatt tttcggtttt atggaaaaaa tatcttgtaa ttcttataga aagcgggaaa 1430101 ctttttcaaa gtttcattcg tctacgatat attgaggtac atccttaaaa cattacatga 1430161 gaaaagaaac atttaaagga agaagggttt ttatgaaatc aataggtgtt gtgagaaaag 1430221 tagatgaatt aggccgcatt gtcatgccga ttgagttgag acgggcattg gatattgcca 1430281 taaaagacag cattgagttt tttgttgacg gagataaaat tatcttgaaa aagtacaaac 1430341 ctcatggcgt ttgtttaatg actggagaaa tcacttcaga aaataaagaa tacggcaacg 1430401 gtaaaattac gctaagccct gagggtgcac agctgcttct cgaagaaatt caagccgctt 1430461 taaaagaata aaattatgct aaaaaaggcg gagtgatatc atctccgcct tttttgcgtg 1430521 ccaatttttg attaccgccg cctaagataa gacatcaaga tatttggtaa tgaatgattt 1430581 gggatacttt acatatttta ctcaattatt tgtcgaagaa tggtacaata agtagagaaa 1430641 cacaagcggc aggtggtcat atgagaaaat atcaagctcg tatcatttcc atcattttgg 1430701 caatgatttt tataatgttt tgggattatt tattttattt tataggcaaa aacccgatta 1430761 attggcctgt tgatattgtg tatactgcag tcacgctggt aagtgtctgg atgttggctt 1430821 attatattga tgagaaacag cagctggtta agaaaatgaa ggataacgaa tggaagtata 1430881 aacagctttc tgaagaaaaa aaccgcatca tggataattt gcaggaaatc gtatttcaaa 1430941 cgaatgcaaa aggtgaaatt acatatttaa accaagcgtg ggcatctata accgggtttt 1431001 caatcagtga atgtatggga acaatgtata acgattactt cataaaagaa aagcacgtag 1431061 ccgaccacat taacacccaa atccaaaaca aagcgtcttc tggcatgttt acggcaaaat 1431121 acgtgacaaa aaacggcacg attttttggg gagaagttca ttataaactt tactatgacc 1431181 gggatgacca atttacaggc agcctgggta caatgtcaga tatcactgag cggaaagagg 1431241 ctgaagatga gctcattgag attaatgaac ggctggcgag ggaatcccag aaactatcaa 1431301 tcacaagtga acttgccgca ggtattgctc atgaggtcag aaacccttta acatctgtca 1431361 gcggtttcct ccagattatg aaaacacaat atccggacag aaaagactat tttgacatca 1431421 tcttttcaga gattaaaaga atcgatttag tgctcagcga gctgctgctg cttgcaaaac 1431481 cgcaggcaat cacatttaaa acacaccagc ttaatgagat cttgaaacaa gtcacgacat 1431541 tgcttgatac caatgcaatt ctgtccaata tcgtcataga gaaaaatttc aaagagacag 1431601 atggctgtat gattaatgga gacgaaaatc agctgaagca ggtctttatc aacatcatta 1431661 aaaacggaat tgaggcaatg ccaaagggcg gtgtcgtaac catttcaact gctaaaaccg 1431721 cctctcatgc agtgataagc gtaaaggatg aaggaaacgg catgccgcag gaaaagctga 1431781 agcagattgg caaacctttt tattcaacaa aagaaaaggg cactggactg ggacttccca 1431841 tttgtttgag aatcctgaag gaacatgacg gggaattgaa aatcgaaagt gaagctggaa 1431901 aaggcagcgt ctttcaagtg gttttgcctt taaaatcaga cagctgagag gagaaaaata 1431961 aagtgaactc gcttctgttt gtatacggga cattaagaaa gcatgaaaaa aaccatcatt 1432021 tgctggcaca atcggcatgt atcaatgagc aggcgagaac aaagggaagt ttgtttgctg 1432081 caaaagaggg gcccacagtt gttttcaatg atgaagatga aggctatata tatggcgaag 1432141 tatatgaagc agatgaattg tgtatacata agctcgatca attttttcaa ggatatcata 1432201 aacaaacggt gtttgtagaa acggatgtcg ggattaaaat tgcgcttatt tattttatga 1432261 acaaagacgg gtgtgccggt tttacgaaaa taagcagcgg cgactggaaa gaacatcaga 1432321 tgatcagcaa atcgaaaaat cccatttatt attttgccta tggatcatgc atggataatg 1432381 cccgctttca aaaagcggga gtcgatcact attttcaaga tccagtagga agagctgttt 1432441 taaaaggata cacaacccgc ttcacgctaa aaagggaaga cggttcaaga gcggacatgt 1432501 tggaagacgg aggaacaaca gaaggcgttt tataccgtat cccttattct gctctctcct 1432561 atctatataa aagggagggc gtcgaatctc ttacgtatcg gccggcattt gtagacgttg 1432621 aagctggcgg aaggcactac aaagactgtt taacctttct cgtcctccaa aaagaagcgg 1432681 aaattgcccc gcctcagcac tatcagattg aaatcgaacg cggagcggag ctgtatttgt 1432741 cgcctgagtt tactgaaaag ctcaagcggc atatgaattc gctgccaaaa ggataacact 1432801 gtaacaaaag aatatgataa aatttgatca atatcatgtc atataaagga gcaccacgat 1432861 gaaaaaagaa tttgcggtaa ttgggctggg ccgttttggt ggcagtattt gcaaagcatt 1432921 aagcgaagaa ggcgtcgagg ttatggcaat ggatatcgat gaagataaag tcaacgagta 1432981 tgccaagatt gcatctcacg cagttatcgg tgattcgaca gacgaatctg tcctgaaaaa 1433041 tttaggcctg cgaaattttg accacgttat tgtagcaatc ggggaaaata ttcaagcgag 1433101 tattttaacg acactcattc tgaaagaact tggcgtccat acgattacag ttaaagcgca 1433161 gaacgattat cacgaaaaag tgctgtctaa aattggtgcg gatcacatcg tccacccgga 1433221 acgcgatatg gcaaaacgaa ttgcgcataa tatcgtgtcc aacaatgtac ttgactattt 1433281 ggagctgtct gaagagcata gtcttgttga aatcgtagct aacagccgcc tggctggaaa 1433341 tacgcttctc gatttagata ttcgcgcaaa atacggtatt aacatcgtag ccataaaaag 1433401 gggcaaggaa gtcatcgtat caccgcttgc aaccgaagtc atccaccaag aagatatact 1433461 cattgttatt ggatcagtta cagacatctc ccgtttcgaa aaaagagttc ttcatacaaa 1433521 atagcagcca aataagccgt cctcaaaggg cggtttttca tattatcaga atataacaac 1433581 tttaatgaac tgagcgtcaa tttcttaaaa tttcattgac taagcacagg cgttccgata 1433641 gcatattgta ccatataata aaaaaaggag gggcctattt gaataaagaa gcgctagtca 1433701 ataggctgaa tgcttcagcc aaaagacaaa aagctgatat cgtcattaaa aacggaaaaa 1433761 tcatggacgt atataatcaa gaatggatat atgaagatat tgcgattaca gatggagtta 1433821 ttgtaggcct cggtgagtat gaaggcgaaa atatcattga tgcagaggga caaatgattg 1433881 ttccgggttt tattgatgga catgtacata ttgagtcgtc aatggttaca ccgattgagt 1433941 tcgctaaagc agtgttgcct catggcgtga cgacggttgt tacagatccg catgagatcg 1434001 cgaatgtgtc tggtgaaaaa gggattgagt ttatgcttga acaagctcgg catacaccgc 1434061 tgaatatcca ttttatgctt ccttccagtg tgcctgccgc aagttttgag cgatcaggcg 1434121 caattctcaa agctgccgat ctcaagcctt tttatgaaga agaagaagta ttagggctgg 1434181 ctgaagttat ggattatgtg tcggttcagc aggctgaaaa agacatggtt cagaaactgc 1434241 ttgatgcccg tgtggcagga aaaaggatag acggtcattt agctggttta tcaacagacc 1434301 tcattaacat ttacagaacc gcatttgtct taaacgacca tgaagtaaca tcgaaggaag 1434361 aagcccttga tcgtatcaga aggggcatgt atgtcatgat gcgtgaagga tcagtcgcca 1434421 aaaacacgct caatgtgctg ccggcggtga atgaaaagaa cgcacgccgg ttctttttct 1434481 gtacggatga taagcatgtg gatgatttat tgtcagaggg aagtgtaaac catcaggtga 1434541 aaatggcgat tcaagccgga cttaatccgt ttttagccta tcagctagga agcctcaatg 1434601 cagccgaatg ctacggatta gatacaaagg gagcgattgc cccgggtttt gacgctgatt 1434661 tgctttttgt atctgatctg gaaaatgtca ctgtcacaat gacgatggta aaagggcaga 1434721 ctgttgctga agacagcaaa gcggtctatc aggatcatgc ttcaactgca gcaccagatc 1434781 aggcactgct tgattctgtt aagcttgctg ctcctcttaa caaacaggat tttcatatgc 1434841 caatcgattc agagcagcag atcaatgtca ttcaaatcat accaaatcag cttgaaacac 1434901 gattagtaca agttccggct cctgttgccc gcgaatttga gcctgacact gagcttgatt 1434961 tgttaaagat tgcagttgtc gagcggcata aaggattaaa agaaaccgga cttggtgttg 1435021 tgaaaggttt tggattcaag agcggagcga ttgccacaac catttcacac gactcccata 1435081 atattattgc cgtcggaacg aatgatgagg atatcgcggc ggcagttaat aagctgcagg 1435141 aaattggcgg aggattaaca attataaaaa atggggaaga gctccattca gtaccgctgc 1435201 cgattgcagg gttattatcc gaccaatctg cagagcaagt gaatcaaagc ttgctgacgc 1435261 ttcatgataa attgtcgtta atcggtttca caggcggatt taatccattt ttgacattgt 1435321 cgtttttagc gttgcctgtc attcctgata ttaaaatgac gactacggga ttattcgatg 1435381 taaaatcatt tcaacacata tcactgcaat aaaaagaggc actcccttag ggagtgcctc 1435441 tttttttaaa cctccataat gatcggcagg atcattggac ggcgctttgt tttttcgtac 1435501 aagaaaggtg caagcgtgtc tgtaatttcg tttttgattt cagaccattg agtcgttttt 1435561 cgttccatta ctttttgtaa gtgatttgaa atgagctctt gagcgtcgtt gatcaagtca 1435621 ccagattctc tcatgtacac aaatcctctg gaaatcaaat caggacccgc tgaaatcttg 1435681 aagtcgtcca tgtcaatgct gacaacaacg atgacaagtc cttcttcaga gagaattctg 1435741 cgatcacgaa gtacgatatt gccaatatca ccgataccgc ttccgtcaat gtacactgaa 1435801 ccggacggga tttttcctgc aactgaagcc tcatcgcctt taagtgctaa tacttcacca 1435861 ttatccatga taaagcagtt ttcctctggg atgccacaat ctgttgcaag tttgacatgc 1435921 atcttttgca ttctgtactc accgtgaatc ggcatgaaga atttaggctt gattaaacga 1435981 agcatcagct tctgttcttc ctgtccgccg tgaccggatg tatggatatc gttaagaggg 1436041 ccgtgaataa cctcagcacc cgcacgatac agctggttga ttgttcgact cacgctgatt 1436101 gtgttgcctg ggatagggga tgaagaaaat acgactgtat ccccaggatt gattgaaatt 1436161 tggcggtgtg tgccgtttgc aattcttgat aacgccgcca ttggttcccc ttggcttcct 1436221 gtacataaaa ttgttacttt attagcaggc atacgattga tttcgttatg ctcaataaac 1436281 gtatttttag gacagttaat ataaccgagt gtctgtccaa tttcgatagc cgattccata 1436341 ctgcgtccaa atacggcaac ttttcttcca ttttgtacag cagcttcaat tacctgctgc 1436401 aagcggtgaa tattcgacgc aaatgtggcg aagataattc ggccgtccac cttgcggaaa 1436461 atgtcatgaa tgctttctcc tacacggcgc tcagacatgg taaactccgg attttcactg 1436521 tttgtgctgt ctgaaagaag gcacaaaacg ccttctttac cgatttcggc cattttcgtt 1436581 aagtttgccg gctcgccgac tggagtaaag tcgaatttga aatccccagt atgtacgatg 1436641 tttccgggcg gcgtttttac aacaatgccg taggaatccg gaatactgtg tgttgttctg 1436701 aagaatgaca cagccgtttt gcggaacttt acaatatcat cctcgccgat aatgttcagt 1436761 ttcgtctgtc tcaataatcc atgctcttca agtttattcc gaagtaagcc gatcgcgagt 1436821 tttccgccgt atacaggaat attcacttgt ctgagcaggt atggaatacc gccgatgtgg 1436881 tcttcgtgcc cgtgggtgat aaaaagccct ttaattttat cttcgttttt gactaaatac 1436941 gtataatcag ggatgacgta gtcaattccg agcagttcgt cctcgggaaa cttgatcccc 1437001 gcatcaatca gtacaatttc atcctggaat tgcaccgcgt acgtattttt accgatttcg 1437061 cccaaacctc cgagggcgaa aacagcagtc tgatcatttt ttacaaattt cataccgctc 1437121 ataactccaa tactttaaaa ttttcgctct gttgttcata ttctaagaat gcaccatcaa 1437181 caggtgtaat aaactcaata ttaaatttct tttctttcag ctttgttctg acgtcacgct 1437241 cagatacgcc ttcaatataa agtgaatctg tcttttcccg aacaggtact tcgtcagcct 1437301 tctcttgata aaatacctta taaatcattc caaatctctc cttaaatgcc gtatgttaga 1437361 ctcgctcatt ctattatatt cgaaaacgga atataaggaa agccttgagc aaaataagga 1437421 tctctcaaaa agtgaaagat cccttgtcag gcaattgctt tcttacggag cattccgttc 1437481 cattgtcttc tgagtttctt tcttaattta cgcagcatta gccagtccct cctttaatga 1437541 aaaatttgtc ccagagttct tttatacaaa tagtatacgg agattgagga agacttttcg 1437601 tggttattaa tggaatttaa tatgattttt gaacgaaatt gtttgctgaa tgacaatctt 1437661 tttgtatgat gagggtggga attgcagacc aagacgataa aggggaagtt gcgatggatt 1437721 ctaaattaat cttttttgat attgacggca caatatatga tcatgataag aatataccgg 1437781 aaagtacgag aaaaaccgtg gcggagcttc agcgccaagg gcatcatgtg tttattgcca 1437841 gcggccggtc tccatttttg gttaagccga ttttggagga gctgggcatc cactcattta 1437901 tttcctacaa tggacagttt gttgtctttg aaaatcaagt gatttataaa aatccgctgc 1437961 ctgaaaatgc aatcaggcga ttattaaagc aggcggatga aggcaagcat cctgttgtgt 1438021 ttatggctga ggacacgatg aaagcgactg ttgcggatca cccccatgtt ctcgagggaa 1438081 tcggcagcct taaaacagat tatccagaga ccgatgacct tttttatgaa ggaaaagaaa 1438141 tttttcagct tcttttattt tgtcaggatg aagaagaaaa agcttatgcc gcttttcctg 1438201 agtttgatct agttcgctgg catgagctat cgactgatgt tctgccgcac ggaggttcga 1438261 aggcagaagg aatcaaaaaa gtgattgagc gtcttccgtt tgatatcggc gatacatatg 1438321 ctttcggcga cggattaaat gatttgcaaa tgattgaata cgttgggaca ggcgttgcta 1438381 tgggaaatgc tgttcccgaa ctgaaagaaa tcgcggactt tgtaacaaaa ccggtggacg 1438441 aggatggaat tgcatacgct gtcaaagaat tgggcctttt aaaataaaga aacggctggc 1438501 attgtgccag ccgttttctc ttttagcgct caattgcgat tgcattttca ggttctttga 1438561 aaggattttc cttatcaata tgatcataga acataacgcc gttcaaatga tcgatctcat 1438621 gctgaaacac aatagccgga aatcctttta aacgaatatc aatattttcg ccttctagtg 1438681 ttgttccttt tactctgatg cgagcatagc ggggaacata accgggaatc gcttcatcca 1438741 cagagaggca gccctcgccg cttgttaagt agcttttttc aactgaatgg ctgacgatct 1438801 taggattaaa cagagcatag ctgtataatt taccggaagc atcttccgca tgaacggcga 1438861 tcattcgttt tttgatatta atttgaggag ctgcgagtcc tacgccaggg cgcagcttgt 1438921 atttttcggc taattctgga ttttggctgt ttttaacaaa ttcgatcatg tcggccagct 1438981 gctgtttttc tgcatcagtt ggaggcagct caacaggttc ggcagtctct ctgagggctg 1439041 gatggccgtc acgtacgatg ttttccatag taatcaagaa acttcactcc taaagcttaa 1439101 tatgtaaatt atatcggatt tcttcacaaa ggtgcaacga aacgaatgac cagccgtata 1439161 tggctggtca atttcatgct gtgtggttag caacagcctc cacctaaata agcagctccg 1439221 acaatgatta acagaatgaa taaaacaacg attagcgcaa aggtgcggcc gtagccatat 1439281 ccgcagccac catatccgta accaccataa ctgcagcagc ctccgccgta accatatcca 1439341 tacatattac ataacctcct cttttaatta cgccagagcc tttataagta ggcatagcgt 1439401 ctaatataac ctatgtaaaa acaaaaaagt tgtatggtca tctgtcctga tttttcactt 1439461 ttttgattta atttcagtat tgcatttata cagcacggct attgccaaat gtccccatgg 1439521 attctatagt agaaattgtc aagattgggg gatttaacgt gaaagacgct ataaaacggc 1439581 ggcctggaat caagatcgga gctttttgtg ccatggcact gatattaaca ggatgcatgg 1439641 gacaggaccc ggttgattca cttcatcatt cattagaaaa agccgcggaa tcggaaaagc 1439701 cgtttcaaga agaacaaaac acactcaaag aattagaggc caaagaaaat cagctttacg 1439761 atagtgttat gaagctcaat atggatgatt ataaaaaaat tgttgcttta tctaataagg 1439821 cgcttgaaaa tgtcagcaag cgcgaagaac acctaaagct tgaaaatgac agcatgaaaa 1439881 aatcggaaac agaatttgag gaagcaaaaa cgtcagcgga acatattaag gaaaaagaca 1439941 taaaagaaaa ggccgatgcc gcagcaaacc atatggagaa aagatataca tcatatggca 1440001 ctatgtataa agagtataaa aaagcgcttg agcttaataa aaaactgtat atgcagctga 1440061 aagacaaaga tttgacaaga gatgatctgg atcagcagat cgataaagtc aatgcttctt 1440121 atgaaaagat ccttaaatat agcggagaat ttaatgaaca aaccgaaaaa tataataaag 1440181 cccgggaaga tttatatgat gctgcaggct atcgtgtgaa aaagagctga ctcgatcagc 1440241 tctttttttg aatgaaatgc gattcggatt tcgttcaaaa ttttcatttc tattgtagta 1440301 cagcatagta aggtatacta gtacagtttt gggtgcggtt ggcatctgtt tttttgatga 1440361 aaatgtaaag cgaatacatt tattgaaaat cagcgatgaa aacgattgac ggttcttctt 1440421 tatttggtgt aaactaatcc atgttaagcg gtgttgtatt agttttttac aacttcgaaa 1440481 taatacagtt caaagcagag tgtaactatc ctacataaaa ggttttggca aactggggat 1440541 cggctaaaat ataatacgac ttactgctga tactttaggg taccctaagt ttgtatgtat 1440601 aaaaggaatg cacgtctaat gactgtttaa aagaaaggaa gaggtgactt agtatggctg 1440661 caaaaacgaa aaaagctatc gttgacagta agaagcaatt tgatgccatt aaaaagcagt 1440721 tcgaaacgtt ccaaatttta aatgaaaagg gagaagtcgt gaatgaagcg gcgatgcctg 1440781 atttaactga tgatcaatta aaagagctaa tgcgccgcat ggtatttacg cgtgtgcttg 1440841 accaacgctc tatctcatta aaccgtcaag gacgtctcgg attttacgct cctactgcgg 1440901 gtcaagaagc ttctcagatt gcaacgcatt tcgcgcttga aaaagaagac tttgttcttc 1440961 ctggataccg tgatgtgcct cagttaattt ggcacggcct tccattatat caagcgtttc 1441021 ttttctctcg cggacatttc agaggaaacc aaatgcctga tgatgtgaat gccctttctc 1441081 cacaaatcat tatcggtgct caatacattc aaactgccgg tgttgcgcta ggtcttaaaa 1441141 aacgcggtaa gaaagctgtc gcaatcactt acactggtga cggcggagct tctcaagggg 1441201 acttctacga aggaattaac tttgccggag cttataaagc acctgcaatc ttcgtggtgc 1441261 aaaacaaccg ttacgcgatt tcaactcctg ttgaaaaaca atctgcagct gaaacaattg 1441321 cacaaaaagc tgtagctgcc ggtattgtcg gcgtacaagt agacggaatg gatccgcttg 1441381 ctgtatacgc agcaactgct gaagcacgcg agcgcgcaat caacggcgaa ggtccaacac 1441441 taattgaaac acttacattc cgttatggcc cgcacacaat ggctggtgac gatcctacta 1441501 aatatcgtac aaaagaaatc gaaaatgagt gggaacaaaa agatccgctt gtacgtttcc 1441561 gtgcgttcct tgaaaacaaa ggcttatggt ctgaagaaga agaagcaaaa gtgattgagg 1441621 atgcgaaaga agaaattaag caagcgatca aaaaagctga tgctgaaccg aagcaaaaag 1441681 taactgattt aatgaaaatc atgtacgaaa aaatgcctca caaccttgag gagcaatttg 1441741 aaatttatac acagaaggag tcgaagtaag ccatggcgca aatgacaatg attcaagcaa 1441801 tcacggatgc gttacgcaca gaactgaaaa atgacgaaaa tgtcttagtt ttcggagaag 1441861 acgttggtgt aaacggcggc gtattccgtg cgacagaagg attgcaaaaa gaattcggtg 1441921 aagaccgtgt gtttgacacg ccacttgctg aatctggtat cggcggtctt gcccttggtt 1441981 taggcttaaa cggcttccgt ccggtaatgg aaatccaatt cttcggattt gtttatgaag 1442041 taatggattc agtttctggc caaatggctc gtatgcgcta ccgttctggc ggacgctgga 1442101 cttcacctgt aacaattcgt tctccattcg gcggcggtgt tcatactcct gaacttcacg 1442161 ctgacagctt ggaaggtctt gttgcacaac agcctggtat caaagttgtt attccatcaa 1442221 ctccttacga tgccaaagga cttttaattt ctgcgatcag agacaatgat cctgttgtct 1442281 tcttagagca tatgaagctt taccgttctt tccgtcagga agttcctgaa gaagaataca 1442341 caattgagct tggaaaagct gacgtgaaac gtgaaggtac tgatctttca atcatcactt 1442401 acggcgcaat ggttcatgaa tcattaaaag ctgctgatga gcttgaaaaa gacggcattt 1442461 ctgctgaagt tgtcgacctt cgtacagtaa gcccacttga tatcgataca attatcgcct 1442521 ctgtagaaaa aacaggacgc gcgattgtcg ttcaagaggc acaaaaacaa gccggtattg 1442581 ctgcaaacgt agtagcagaa attaatgacc gtgcgatcct gagcttggaa gcacctgtac 1442641 ttcgcgttgc agcgccagat acagtatttc ctttctctca agcggagagc gtatggcttc 1442701 caaaccataa agacgttctt gaaacagcaa gaaaagtgct tgaattttaa tcaaactgca 1442761 taatcgagag ggaagatgaa cgttttccct ctattatata tctgttttca atgcttacga 1442821 tgtaaacttt aaaattgctt aatcaaacta ggaggtcgag aactgtggca tttgaattta 1442881 aacttccaga tatcggggaa ggtatccacg aaggcgaaat cgtaaaatgg tttgtcaagc 1442941 ctaacgacga ggtagacgaa gatgatgtac tggctgaagt ccaaaatgat aaagcagtag 1443001 tagaaattcc ttcacctgtt aaaggaaaag tattagaatt aaaagttgaa gagggaacgg 1443061 ttgcaactgt tggacaaacg attattacgt ttgatgcacc tggttacgaa gatcttcaat 1443121 ttaaaggcag cgacgagtct gacgatgcga aaactgaagc acaagttcag tcaactgcag 1443181 aagctggaca agacgttgcg aaagaagagc aagctcaaga gcctgcaaaa gctactggcg 1443241 caggacagca ggatcaagct gaagttgacc cgaacaaacg cgtgatcgct atgccttccg 1443301 tacgtaaata tgcacgtgaa aaaggtgtag acatccgtaa ggttactggt tcaggcaaca 1443361 acggacgtgt tgtaaaagaa gatatcgaca gctttgtaaa cggaggagcg caagaagctg 1443421 caccgcaaga aacagctgca ccacaagaaa cagctgctaa accggctgct gcaccagctc 1443481 cagagggcga attcccagaa acacgcgaaa aaatgagcgg tatccgtaaa gcaattgcaa 1443541 aagcgatggt taactctaaa cacactgctc ctcacgtaac gttaatggac gaagtggacg 1443601 taacaaacct tgttgcacat cgtaaacagt tcaaacaggt tgctgctgat caaggaatca 1443661 agctgactta cttgccttac gttgtaaaag ctcttacatc tgcactgaaa aaattccctg 1443721 ttttaaacac gtcaattgac gataaaacag atgaagtcat ccaaaaacat tacttcaaca 1443781 tcggtatcgc tgctgacact gaaaaaggct tgcttgtacc ggttgtgaaa aatgcagatc 1443841 gtaaatctgt ctttgaaatt tctgatgaaa tcaatggcct tgcaacaaaa gctcgtgaag 1443901 gcaagcttgc tccagctgaa atgaaaggcg catcttgcac aattacaaac atcggttctg 1443961 ccggcggaca atggttcact ccggttatca accatccaga agttgcgatt cttggtatcg 1444021 gacgcattgc agaaaaagcg attgttcgtg atggcgaaat cgtagcagct ccagtcttag 1444081 ctctttctct cagcttcgac caccgtatga tcgacggagc aactgcgcaa aatgcattaa 1444141 atcacatcaa gcgtttactg aacgatccac aattaatttt aatggaggcg taatgttatg 1444201 gtagtaggag atttccctat tgaaacagat actcttgtaa ttggtgcggg acctggcggc 1444261 tatgtagctg ccatccgcgc tgcacagctt ggacaaaaag taacagtcgt tgaaaaagca 1444321 actcttggag gcgtttgtct gaacgttgga tgtatccctt caaaagcgct gatcaatgca 1444381 ggtcaccgtt atgagaatgc aaaacattct gatgacatgg gaatcactgc tgagaatgta 1444441 acagttgatt tcacaaaagt tcaagaatgg aaagcttctg ttgtcaacaa gcttactggc 1444501 ggtgtagcag gtcttcttaa aggcaacaaa gtagatgttg taaaaggtga agcttacttt 1444561 gtagacagca attcagttcg tgttatggat gagaactctg ctcaaacata cacgtttaaa 1444621 aacgcaatca ttgctactgg ttctcgtcct atcgaattgc caaacttcaa atatagtgag 1444681 cgtgtcctga attcaactgg cgctttggct cttaaagaaa ttcctaaaaa gctcgttgtt 1444741 atcggcggcg gatacatcgg aactgaactt ggaactgcgt atgctaactt cggtactgaa 1444801 cttgttattc ttgaaggcgg agatgaaatt cttcctggct tcgaaaaaca aatgagttct 1444861 ctcgttacac gcagactgaa gaaaaaaggc aacgttgaaa tccatacaaa cgcgatggct 1444921 aaaggcgttg aagaaagacc agacggcgta acagttactt tcgaagtaaa aggcgaagaa 1444981 aaaactgttg atgctgatta cgtattgatt acagtaggac gccgtccaaa cactgatgag 1445041 cttggtcttg agcaagtcgg tatcgaaatg acggaccgcg gtatcgtgaa aactgacaaa 1445101 cagtgccgca caaacgtacc taacatttat gcaatcggtg atatcatcga aggaccgccg 1445161 cttgctcata aagcatctta cgaaggtaaa atcgctgcag aagctatcgc tggagagcct 1445221 gcagaaatcg attaccttgg tattcctgcg gttgttttct ctgagcctga acttgcatca 1445281 gttggttaca ctgaagcaca ggcgaaagaa gaaggtcttg acattgttgc tgctaaattc 1445341 ccatttgcag caaacggccg cgcgctttct cttaacgaaa cagacggctt catgaagctg 1445401 atcactcgta aagaggacgg tcttgtgatc ggtgcgcaaa tcgccggagc aagtgcttct 1445461 gatatgattt ctgaattaag cttagcgatt gaaggcggca tgactgctga agatatcgca 1445521 atgacaattc acgctcaccc aacattgggc gaaatcacaa tggaagctgc tgaagtggca 1445581 atcggaagtc cgattcacat cgtaaaataa ttttcatatc aaaaacagcc ccgctttgag 1445641 cgagggctgt ttttttattt tgacagcaca tgctgtaatg gtttaatgat gtcttctttc 1445701 tttttcacac atccctcgat tttcaccacg acatggcgct gatcaacaac cataagggta 1445761 gggacagttt caatctcatc ttcccagcct tcttttttat catagacctt cattttatct 1445821 atttgctcgg gataatcttt ttctaaatca agcagtgcat cgtaataagg cgcttcctgg 1445881 tctatttggt tctcatcaga aaaaaacagg atttgtgtat gatgaatgtt gtcaatccgg 1445941 ctttttttca tcggattgat ggtggaaagc gtacagcccg ataaagcaaa tactattatc 1446001 agcatgggga ataccgcgcg atatcgcatc tatcttctcc tctgtataaa cagtagttaa 1446061 ctagctttag tttatcacga gagacggctt aatctgcttc ttgttaccta attgttatat 1446121 aattgaaacc gtttttaaag tgagattaca tattatatca atcgtttaaa atagcaacct 1446181 ggggtatatt gaattttttg ctgcattctt ggatgaaagt tcaagaaaac gtgcaattac 1446241 attatgtgct gtggcatata tatcgagtaa agcttctgta tgaagaagat attgtatgat 1446301 ggaaaatgga aaaacaaggt gaatatgatg atatgaaata aaatgtgtta tacagtttgt 1446361 tgttgacatt ttaaatgtga catattaata taataacaac aaaagaaatt aagcgttttc 1446421 aaatttcaaa gaaatgggga ataagagatg ggtacgattg tttgccaaga ttgcaacgaa 1446481 gccattcatt actttgaaga tgagaaagtg acaacattat atggaacttg ctgcggacaa 1446541 tgtcaatgtc ctgttgatga agagtaaaaa aaagcatgcg gcttaaagcc gcatgctttt 1446601 tattttttat tgaattgctt tttgttcttt gatgacccgg atcatatgta aagtcgagtc 1446661 ctcaggtcct tgaacaggga ggcctgcgtc aaggttttta aaaatgtagc tgatgttttc 1446721 ttctgtaata atttctcctg ggatgaagat tggaatacca ggcggatata ccatgacaaa 1446781 ttcagcaata atccgtccgg atgcttcttt taatgggatg acttccgtat ttgcatagaa 1446841 agcatcacgc ggagtcattg ccaataaagg tatttctgga agcagaacct cagtttgctg 1446901 atgtgttaca tcttgttctg acatttgctg tgcgatctca gttaaagcct ctacaagccg 1446961 gtctgcatca ttttggctgt caccaggagt gaaaatacac aaaatattgt acagatcaga 1447021 aagctccacc tcaatattaa aggattcacg aagccatttt tccacgtcat gtcctgtcag 1447081 gccaagactt ttcacagaga taatcaattt tgtcggatca tagctgtaag ctgctttcga 1447141 cccaagaatc tcagaaccga cacaataaat gccttcaatc tgattgaggc gatctctcgt 1447201 ctgattggca agcttgagtg tttcctcagc aagctggcgg ccttctgttg caaggcgttt 1447261 tctggcaaca tccaaagaag cgagaagcaa gtaagaagtt gacgtagttg tcagcatgct 1447321 caggatggat tgcactctgt ctttagatac aaggccttct ctcatgttta aaatagagct 1447381 ttgtgtcagt gatccgccca gcttgtgtac acttgtcgct gctatgtccg ctcctgcctg 1447441 catagccgat agcggcaatt cgtcgtgaaa atgaatgtga acgccgtgtg cttcatccac 1447501 aagcactggc acatcaaacg aatgagcgag ttctacgatg ctttttaagt cggctgcaac 1447561 accgaaatat gtcgggttga tgacgagaag cccttttgca tccggatgct cggtaagcgc 1447621 ccgtttagca gattcaagtg taattccgtg ggagatgccc aattcattgt caatttcagg 1447681 atgaataaaa attggaaccg ctccggaaaa tacaatagct gtcataattg atttatgaac 1447741 atttcttgga ataataattt tatcaccagg tccgcaaaca gccattacca ttgtcataat 1447801 ggcgccgctt gttccttgaa cagaaaaaaa tgtatgatcc gctccaaatg cttcagcagc 1447861 cagatcttgt gcttgtttaa taatgccttt tggcgcgtgc agatcgtcta atggttcaat 1447921 attaatcaaa tctatgctta acgcgttttc accgataaat tgtctgaatt ctgggtccat 1447981 tcctgcccct tttttatggc cgggaatgtg gaattgaaca ggctgtctgc ttgcatgctt 1448041 tttcagtcct gtgtataagg gtgtttcatg ttgcgacaat tgttttccca cctttgtaat 1448101 catacctatg cataatagtg tgtattaaaa tcagtttctc aaccgttttt tagacgtaaa 1448161 acaaatgaat tatattatga acttgaaaga atgtaaagaa caatttatga tcaaatgaag 1448221 atgctttctc ttaagggaag taaatctaca aggagtgaag aaaatggagt atcaatatcc 1448281 gatgaatgaa gattggacaa ccgaagaagc agtggatgtg attgcatttt tccagcaggt 1448341 tgagcttgca tatgaaaaag gggcggatcg tgaagaactg cttaaagctt accgccgttt 1448401 caaggaaatt gtaccgggga aggccgaaga aaaaaagcta tgcggcgagt ttgaggaaca 1448461 aagtacatat tctccttatc gcacggtcaa acaggcgaga gaatctgatc acgcgaagat 1448521 taagatgtaa gaaaaagagc cgggggatat cccggctctt ttttatgctt gtgttacttt 1448581 ttgggtgaga cggtacagaa aagcaagctg tttaaaggca tcgtcgatac gctgaaggaa 1448641 ttcctggtta ttcatattca gcacttcttc tttttggagc tggatgccgc ataacagctc 1448701 ggctttcttt acagtctgca aacgctcaaa cagtgtcttc agctgttcct tgtccatttc 1448761 agactgttta tgtactcccg gttttgtgtg atctgcagac caaacgaagc tgtcagggat 1448821 atttttcgta atggtttctt ggttcacttc aagcaatttg ccgtattctt ctttgatagg 1448881 ggattcataa ataatcgcga accatacaaa gacgtggctt tcccataaac caatttggaa 1448941 atgcggcagt tttttatagc ctcttttgct gtttgcgaac gccacccagc tgtcagccgg 1449001 gggattgacg gatcttcttg cgtgctttgc cacatgcgga aacatttcat ctccggttaa 1449061 agctgataaa gttggggcaa aatgttcgcc tagagctgta agcttcggac ggaccgtctc 1449121 ttttaatact tccatgcgcg cgtctaagcc ttctattgta aatgtgttaa agtcttcttc 1449181 agtgaaacgc atttgtgtca tgattttcct ccttcatgct aagtatacat attttatcac 1449241 agttcatacg agcttcaaaa agattgagcg cgtttgaagt aaggagaaat gtggtaataa 1449301 acgagtaggt aaacacacaa ttttcagaat catgttgcgc gtaaatagaa caatcatacg 1449361 atataagaag taatcattgt tgaatggcaa aatgggatgc ttttttacaa acaaatgatc 1449421 tctggaaggg gcgaaagaca atgaggcaag ttgtaaaaga gggatttaag gaagagaaaa 1449481 acaatcgtgt tgctgtctgg agactagagg ttgattatga attggcaacc ctatatgaag 1449541 caatgcagaa agaaaatgaa gagcagattg aacaaagcaa aaacaaactt gagcgactta 1449601 gaaaagaatg gattcgtctt aacgggtaaa aaagcgatag tgaaaacgaa ccgcatgaat 1449661 ggttcgtttt tacgtgagaa gggatatttt tcattttcct tgctttttca ttgccgttat 1449721 cagtatccta taaaataaaa ggtctacata gaagagaggt acgaacgaat gacaaattgg 1449781 acggaaatcg atgagattgc aaagaaatgg ataagagaag caggcgcgag aattacacaa 1449841 tccatgcatg aaagcctgac aattgaaacg aaatcaaatc cgaatgattt agtcaccaat 1449901 attgacaaag aaaccgaaaa gtttttcatt gatcgaattc aagaaacatt tccgggacat 1449961 cggatactcg gtgaagaggg gcaaggagac aaaatccact cacttgaggg agtcgtatgg 1450021 attattgatc cgattgatgg gacgatgaat tttgtgcacc agcaaagaaa ttttgcgatt 1450081 tccattggga tttttgaaaa cggtgaaggt aaaatcggtt taatttatga tgtggtgcac 1450141 gatgagttgt atcacgcatt tagcggcaga ggagcttata tgaatgaaac gaagctggct 1450201 ccattaaaag aaaccgtcat tgaagaagcg attcttgcca ttaatgcaac atgggtaacg 1450261 gaaaacagaa gaattgatca aagtgtgtta gcgccacttg tgaaaagagt cagaggcaca 1450321 cgctcctacg gttctgccgc tttagagctg gcaaatgtcg cggcaggaag aatagatgct 1450381 tacatcacga tgcggcttgc gccatgggac tacgcagccg gctgtgtgct gttaaatgaa 1450441 gtaggaggca cctatacgac cattgaagga gagccgttta cctttttaga aaaccacagt 1450501 gtgctagccg gaaacccatc tatacataaa acgatatttg aagagtatct tcatgctcgg 1450561 aagtaggcca tttgagcagg atgatctcag cttgttagaa aagctcgcgg aggctcatcc 1450621 tgtatggaaa gaggaggagt ttggagataa agatgcagaa gactatatca tttcctactc 1450681 catgtacaac ggttcatggc ttgtatggga aaaagacggt atgcctgttg ccgtcagcta 1450741 ccatctcgag tggtctcctt caaacggtaa gccgtggctc ggaacggtcc tgattgaccc 1450801 ggctgaagaa aaaaagggac atgcgaagat gatcattgaa cagatcagca aattgcttag 1450861 agcgaaacat aaagcgatgt ttgcgggagt tcccattgag cgcagggaat ggatactgtt 1450921 tttaagccaa tgcggctttg aacagctgaa aacggaaaaa gatgagaaag gcaaatcatt 1450981 tatgatcttg gtgaagcctt tagcagaagc tgccgtatga taatggcagc ttatttgctg 1451041 catgcgggtt caataaaaag cctctcaaac attgagaggc ttctgatgat ttgaaaatta 1451101 tttttttacc gcatgaatat aatgaatcgt ttcaaacgct gacaaattgt cttttcgatt 1451161 actaaagaaa aggtcattga tgtcgtctgg tgatagatgt tcatagatca gtaaaccaga 1451221 tgactctaac agatgttcaa tctcttgata agtgaaacat gatttcatcg gttccccgct 1451281 tgcggcagcc atcttcacca tatgttcaac tcgattcgac gtcccttttg ctgtaaaaag 1451341 tgtttcgtcc gcataatcaa aaacaataga gcttccaggc gggacatgag aaaataaatt 1451401 gctgatcaag cttgcatttt cttcccgtgt tacataataa gacactccga gaaggctgaa 1451461 gaatgttttt gtgtttttaa atccttcatc taagagagga tcatacgaaa acgttttggt 1451521 gaaatccata ggaacaaaat gaagatgacc cggaattgtc agatttgcat ccttcagctt 1451581 attttttttc aattgctgtg tggccggatg atcaacctcg aaaacctgta agctgttttc 1451641 taattctgga tgccgaaagc agaaagtatc cagtcccgct ccaagaatga catactgttt 1451701 tgcccccagg attaattcgt tgtgcaagac tttttcacaa taagaagcac gtgctagggg 1451761 cgttggagac agctggattt gtgcaaccca ttttaatatt ttttcaggat cattttgaag 1451821 acgttcggcg atctctttgt tgaaaaacga tatttcttga atcatatttt tactgatgtc 1451881 gataaactct ttttcgttaa tgagatcttt tgcgataaaa tcatcaaaaa taagaggtgt 1451941 gtcatatcgg ctgtgatatg cacgggcaaa agctgaaatt agagacgtta agctggactc 1452001 atttttcctc atgaaatgat cctccacaaa aaataagatt cccctggcca ggagaatctt 1452061 attatacata caaatatatt aatagtaaat tttagcataa ataaattttt ttgtcaatgt 1452121 ttttgctctt aactggacgc gcgatccttc acatagccac gtgacctgta gcagaattcg 1452181 tctatcaatt atgtggactg aatcattagc ttttataaaa tgcgcacttg cggctgcatc 1452241 cctctttatg caaatcagga gcggttttct gtctcatggc agcatctttt cgtcgtttca 1452301 gctgagagag aaatcaagat atgtaacaat aaaagcctga gggatctcag gcttttccta 1452361 atattacaat ccaacagcat tccaggctgc ttcaacttta gcggcatcag ttgagccgta 1452421 gaggtcacgg gcagactgaa tgagagctgc cttggcatct ttgaacgtgg aagaaggcgt 1452481 gaggtacgtt gttaacgcac ggtaatagat ttgctgtgat ttagatacac caagttttgt 1452541 gatggtgttg taagcggctt tgtttggaat tccgctgttt gtgtgtacac cgccataatc 1452601 gccttcatct gtgtttggaa ggtttcggta attggcgtaa ttgtcaggct ggttgtattt 1452661 tgtagggttg gacaggctgc gaagagcagg ctggctgacc gtaatgtctt caccgatgtc 1452721 ccagtcttct gtatcgttaa aatacccgaa tacgtcagag aaagactcgt ttaatgcacc 1452781 tggctgattt tcataaatca agttggctgt ttcttgggtg acgccatgtg tcatttcatg 1452841 cgctgtcaca tctaatgagc cggaaagcgg agagaagaat gaaccgtcgc catcaccgta 1452901 aatcatctgg tctcctgtcc atgcagcgtt attgtattga gtgccgtagt gaacggaaga 1452961 aacgatttta ctgcctttgt tatcatagct gtttcgttta aagtttgaat aaaaataatc 1453021 gtacacttta ccgaggttat agtgtgcgtc aacggctgcc cgctgtgatg aagatgtaaa 1453081 tgttttcgtt gtgcttgaga caagcgtgcc cggaaggcgg ctttgtctgt tttgcaaatc 1453141 atatgtgatg atttgggtgc ctgttggttt tgaaagatct cttagaacat attttccgcc 1453201 ttcataagag atgttcaaag gaacagttgc gccctttagc gttgttccgc ttccagtggc 1453261 ggcggcatgt tctactttat tttgctgttt taaaatgctg cctgtttcgg cgtcaactaa 1453321 gacttcccag tttgcaggtt caggctcgac atagcgaatc gtcacgtcgt aagcaagacg 1453381 atagctgccg tcttttgttt ctatcgcttt taattcggct ttattgctgt ttttggccgc 1453441 tccgttagaa acagcgtctg gtgatttgcc gatagctttg aaagcgagtg ccagcgcttt 1453501 ttcagaagag actttttggc tgttatctgt ttttgcagca gattgattgt gtaattcacc 1453561 attgaccgca tagacattat cggatttatc gacgtgaacg atcacttgcg aatctttaat 1453621 tggcactccg ttaacgacag gcgcatatcg aaagtgcttg tatccaaggg catcagtcgt 1453681 gctttcaaca agcttcagcc ttttggaagg gtcaccttta aaaatgttgc tgttcttttt 1453741 caaaaactgc ttgacagcct tgtcatttgg tgcagagagt tctgattgcg caatcgcgtt 1453801 tttggagagg aaatttgttt gattctcttt aagctgatga ccttcagcag cctgaacacc 1453861 tggcaggctg attgataaac tcataaacga agcagcgaca gcaacagaca atttcttacc 1453921 taaacccaca ataaatcccc ctttttgaaa atactgaaaa ctttatattg ttatattaaa 1453981 ctagcattct ggaatactca acaaaaacta acataactag acaaaattga tagtattgtc 1454041 ctgtgtttgt ttttgttgaa taatatcaag atgagtcaag tgtcatgtgg tggttcattc 1454101 aagagttatg ttttttacat atcaagggga agatgagata tttttgtttc atcttgaaac 1454161 tttttgaaaa gtccgctgtc taaccgaatg aggccttaat aagaagtaaa ggattgttgt 1454221 tcgtgttgga gttattcagt cattatgtat tgcatttcga acgttatttt atattaagca 1454281 gacaaagcac cctgctgatt caatggtcaa ttgttgttct ggcgggctta tatcttttgg 1454341 tgcatcatcc caaaataaac cggcagcgca caatgttctt ggcgggtgtt atattgcgga 1454401 ttgtgctgct ggcgggagtg tctgttgaac ttattcacca ggtgcaatca acaaacttca 1454461 ccagcgctta cttaagagag gacggaaaag aactgctgcc gctgctgcat tttttgttat 1454521 acggatatgt gctgctgacg gcttttcact atatgctgat gccgcgtgat catggcggaa 1454581 agggtaagtt ttatacgttc gaccttgctg ttgtcagttt gccgatcgta caaatgattt 1454641 ttagtttctt ttcgtattgg aaggaatacc cggatgggat ggagccgatt gcattcgtgt 1454701 ttctgttttt catcatcact cttcccattg cgttgaatgt agtgtttttc aagctgtatt 1454761 ggagaacgga taagatctta ctaggcttat tttatacgct gattatcgga ctgcttgtct 1454821 tgctgcttgc gccatatccc aatcaaatct caaaagatta tggtgcagta atgccatata 1454881 cgatttattt ggcaatggcg ggatttttga tgagctatca tctgttccaa aagtcaggaa 1454941 aggtttatgt gcgtgtgaat aagtgggtga cgatggctgt catggtgttt tttgtcctgc 1455001 tgttaaatcc gatatataac ataggaacgg ctgctttcgc tgtatcaaag ccagcaaatg 1455061 tccatgattc attcaatttt gtcggggagc acatttcatc agaaaaagcg gaacagatac 1455121 taaagtcatt ttttcctacg gatgaaacac tttatttgca cgatacaaac atggatgtgc 1455181 attatttcta ctcatttgaa agcaaaggtt acaaagctga ggtagatgaa gtatcgcagc 1455241 taattcgtaa ttatgaatac ttacaaaaag cacatgggaa aaagctaacg aatcaggagt 1455301 acaagcgaaa gtccatcgct ttccttgagc gacacggacg tgtgttacat aaggatcata 1455361 tcgaaacaaa ggtatctcaa gaagacggcc agacagtcgt acgtatttac ctgaaaaatc 1455421 aacttcataa aaaagatcat gctgatgatg gcgcggtatt ttattgggaa aaggaaacct 1455481 taatggggtt tagtgaagat ccttcgattt atcagcttga ctctcttctg catgttcata 1455541 taacggaaca agacattcac gacaaagtgg aacaaatgtt tacagcgctg aacatatcaa 1455601 aacagcctta tcagatcact gatattgaaa gcgacagcct gcttggaagc atggtgagag 1455661 ttgaaacaaa agttggaatt gttttggaat ttgagggcga atcaggttgt ttacatagtc 1455721 tttcgcttcc gatgaaaaag aatatctcaa tggctaacag ccggctgcag catcagatat 1455781 tatcgatctt cgatgctcgt ggatcagaaa agaagaaaaa aagcagtcag ggtgacatgg 1455841 tgatgtatac tgattcttct aaaacatatg agtttgttga agctcaaggt cagctaaacg 1455901 tttatgtata cagcgataca cctgatcagt cattccccta tacgtatcgt aatggaacat 1455961 tggcttacga aaaagtagct tctctatatc aggatgtcat ttacaaaaag cgtatgcgtc 1456021 cgattatcgt tcaaagaggg gatgaacggc attatgcatg gctgatcatt attcagccgt 1456081 ttggttcaaa tcgccatgat gcctatgtag tggatggaga aacacaagag gtgaaaagtc 1456141 tttatgaatc ataaagaaaa agagtctgtt tttgtagact tatacgacct gtataaagaa 1456201 ggagagctag aggatgaatc aatggaatgg atgaaacagc atgaatccct atttcaaaag 1456261 aatgcggaag acttaaagag taaaacttgt ttaaagagaa gtcccggtgc tgaagaagaa 1456321 agccaaatca gatatatgaa agtatacctg tcttccatgt atatctgttt cattttattg 1456381 gccatttgga tgacggtgtg gttttatttt taatgaagca tagggattcc attgaggact 1456441 tgtatcggca gtattatcaa gaaattttaa attatttatt cagaaggact catcatcttg 1456501 aaacagccaa ggacttagcg caggacacgt ttgtaaaagc tcttaacggt ctggcttcgt 1456561 ttagggggca ttcttccatc agaacatggc tctacaccat tgcgcatcat acctttatca 1456621 attggtaccg aagggatgtc aaataccaat ttactgaaat cagcaaaaat gaagggttaa 1456681 cgcaaacaac ttatgaccag cctgaacagt atctgtcacg gacggtgaaa agcgaaacac 1456741 tgcggcagga gctcctgaag ttaaaagatc agcatcaatc cgttttgatt ttaagagaat 1456801 tccaagagct ttcttatgaa gaaatcgctg agatattagg atggagtctt tctaaggtga 1456861 ataccacatt gcaccgggct agattagagc taaagaaaaa catgacgaaa agtagagagg 1456921 aggagcggat atgacctgct ttctagtaag agacctgctt cctctgtatc ttgaaggtga 1456981 ttgtaaaaga gaaacggaac acgttataga agagcattta aaaatgtgca gcagctgcag 1457041 agacatgtat gacacgatgg ctgagccatt tgaattggaa agcgaacagg ccgttgagga 1457101 ggcttatctg ccggaagaag aactgcgttt taaacagagg tactatggat tactgatcat 1457161 gaaagctgcc tgctggtttg gagcggcggt tgccatgatg ctgatcatca aactgctgat 1457221 ataaaaaaag cgcttgtccg attccggcaa gcgctttttt acattaagcc tggggatgaa 1457281 tcatatcgta aatagcggca agctgttctt gtgacagggc actgaagagt ttttcataaa 1457341 cgtcagcttg cagtggcgtt gcacctgctt gtagcgctgc gtctttatca tagctgtaca 1457401 catcatcttg tagcacaatg gctgcttgaa gaatgtgaat cttgagagaa acagcggaga 1457461 aaaattgttc aagtgcaagt gcttcttttt ctgtgaagcc aagttcaact gctttttctg 1457521 tatcaaattt gtaatttcca tcctcgagat acacacattg tgaaacaatg ctgaaaaatt 1457581 ctgatgtcga ttcccagagt gtagcaatta cctgagcctc ttcttttgtc attcctaact 1457641 cgacagcttt ttcgctgtca aaataatata caccgtcttg ttcgtatata cattgattta 1457701 atatatcaat gaatgtattg agatcttcgt tagtgctcgc ctgatgctgg agttgaacag 1457761 cagtgttatc aaccggtgtt tttgcgctgg ctgcatcagg accgaacgtt aatagagcag 1457821 ctgaggtcat tgcggcagtc gttaacatag ctttttttac aaatgttttc ttcatgtttc 1457881 ttctctccct tttatgaatt gtgctacaaa ttccattata gggagtagtt tccggtggag 1457941 gaataggcgc tatggtattt tatgtgtatc gttgccgaac tactttttga aggctgcacg 1458001 tgtgatcgtt agaacgattg tctatgtatg aaggctgttt tgcatcttcc tgactaagaa 1458061 acaggggaga taaggcttaa agaaatgaaa aacaccgctt tctttgcggt gttttttgat 1458121 tacaatgtcg ccggcggggc aatgctttta atcaagcaag ccttgttcgc gcattttctt 1458181 ttttaatgta aatccgccgc ccatgacagc gcaaacaagt acaatgctgg cgataatgcc 1458241 tgcagggctt ttttcagcga taaagacgcc gatcagcata atgctgaaaa ccgctgcaaa 1458301 tgcaaataat agtaaaagcc aattcatttt tttcataaat tccatcccct tttacgtctt 1458361 atattaagtt tacagaaaaa cgtgacgctt ttaaagagga tgtgtgatat aatatgaaag 1458421 ttatctaatt tttttaggag atgaaaaagt gaaacttcga aatgatcttc gcaacatcgc 1458481 gattattgcc cacgttgacc atgggaaaac gactctagtc gatcagcttt tacatcaggc 1458541 tggtacgttc cgtgccaacg aacaggttgc tgaacgcgca atggactcta atgatcttga 1458601 acgcgaacgc ggcattacaa tattggcgaa aaatactgcg attaactata aagatacacg 1458661 tatcaatatt ttggacaccc ctggacatgc agactttggg ggagaagtag aacggattat 1458721 gaaaatggtt gacggcgtag tgcttgtcgt tgacgcatat gaaggctgta tgcctcaaac 1458781 tcgttttgtt ctgaaaaaag ctcttgagca aaacctgaac cctgttgttg ttgtaaacaa 1458841 aattgaccgt gactttgctc gtccagagga agttatcgat gaagttctgg atctgttcat 1458901 tgagcttgat gccaatgaag agcagctcga gttcccagtg gtatatgctt ccgcgattaa 1458961 tggaacagcg agtcttgatc cgaaacaaca ggatgaaaac atggaagctt tatatgaaac 1459021 cattattaag catgttccgg cacctgttga taatgcagag gagccgcttc aattccaagt 1459081 tgcccttctt gactacaacg actatgtagg ccgtatcgga atcggacgcg tattccgcgg 1459141 cacaatgaaa gtcggacagc aggtttctct tatgaagctt gacggaacgg caaagtcatt 1459201 ccgtgttaca aagatttttg gtttccaagg cttaaagcgt gtggaaattg aagaagcaaa 1459261 agcgggagac ctcgttgcgg tttccgggat ggaagatatc aacgttggtg aaacggtatg 1459321 tcctgtagac catcaagatc cgcttccggt ccttcgcatt gatgagccga cacttcaaat 1459381 gacatttgtc gtgaataaca gtccgtttgc aggccgtgaa ggcaaatatg taacggcccg 1459441 caaaatcgaa gagcgtcttc aatcacagct tcagacggat gtgagcttgc gtgttgagcc 1459501 aacagcttct cctgatgctt gggttgtttc aggacgcggt gagctgcact tgtcaatttt 1459561 aattgaaaat atgcgtcgtg agggctatga gcttcaagtg tcaaaacctg aagttattat 1459621 caaagaaatc gacggcgtac gctgtgagcc tgttgaacgt gtgcaaattg atgttcctga 1459681 agagcatact ggctctgtaa tggaatcaat gggtgcccgc aaaggcgaaa tggttgatat 1459741 gatcaacaac ggaaacggcc aagtccgtct catctttaca gttccttccc gcggattgat 1459801 cggttactct acagaattcc tatcattaac acgcggattc ggtattttga accatacgtt 1459861 tgacagctac cagccgatgc aggcaggcca agtcggcgga cgccgtcaag gtgtacttgt 1459921 gtcaatggaa aacggaaaag caacatcata cggtattcaa ggaattgaag accgcggtgt 1459981 catcttcgtt gagccgggta ctgaagtata cgaaggaatg atcgttggag agcataaccg 1460041 tgacaacgac cttgttgtta acgtcagcaa aatgaaacag caaacaaacg tccgttctgc 1460101 gacaaaggat cagacaacta caattaaaaa agcgcgcatc atgtctcttg aggagtctct 1460161 agagtactta aacgaagatg aatattgtga agtaacacct gaatccatcc gtttaagaaa 1460221 gaagatcctc aataagaacg aacgtgaaaa agcagctaaa aagaaaaaaa cagcaggatt 1460281 gtcttaatct cgtgcagaat ttgaaaagat agaacccgta cgtttacagg ggagggaatc 1460341 tttttgaatg acgtaagcga acgcctgtcg ttcttcgccg ctctatatca agtagaccgg 1460401 cagcctgcgg caggcatgtg gctgctgtac ggcacgattt ttgtgttggc cgttattgta 1460461 tttaagcttg gatttgctaa acggcttcct gtattaaaat ctgcagtggt gtatgtattt 1460521 ttggctttgg gctgcactgt tttgactttt ttaggggtgt ttttgcccgt ggcagaagga 1460581 ttggtcgtcg ctgcgctgat tttaatcatt tacaaaatcc ggctgtatca gtcgaaaaaa 1460641 ggacagtctg caaaatcata aaagactcag ctgaaagctg agtctttttt gtgttctgta 1460701 tggttaagcg gccgctttat tttttgactt tttctttttt ctgctgtccc gggtgaaaag 1460761 taaattttcc cgttttcagc cgttcctctg tttttttggc aatccgatcg tggcattcct 1460821 ggcacatata tgtatggatc gggcggtttc gaagccgttt cgcgatcagg gtatcatcat 1460881 caattgtttc aattttatcg caaatagaac atttgaccct catcatatca cctctttcac 1460941 taacatgtat tataccacgg atcagaagct gtccaaaata agaaaaagct aaagcgcaag 1461001 gctatagctt agtcattgtt gttctttttc atatgatgat cagattgatc gttttgttcc 1461061 ttctccattt cctgttgctg ttttctattt aattggtcat tttgctgctt tgtttgcggt 1461121 tcatcttcat tgtcaatcac atcgttaggc acttcgggaa gcactcggcc gacaattgca 1461181 gctaattcat ccagtatacc tgttaccgga tggccctcgc tgatttctct gctcatttcg 1461241 cgaaggcggc tgaccgtatc gggatcagca atgactactg cgttggcgcc atatcgatca 1461301 ttctttagcg cctgagctac agaatattta atggtttcca ctttgcttct gtccaaagta 1461361 tcatcgacat caatcccaac aacagcatag cctcccagca caacggctgt tgcatccttg 1461421 acgtcggggt ttttttcagc aacgctgaca agatgcttgg caatatccgt tcttgttcca 1461481 ttgtcttttg tttcttgagt tgtgtccttt acgtgaatcg gtttagtctc ctgctgtctt 1461541 gttgattctt tttcaacatt ctggccctgt tttccttgtt gataggcaca agcggacagg 1461601 ataagtgtca gctgtatgat aatgaaaaga attcgcactt gcgggttccc tccttaaaat 1461661 gctttcatta attttattgt tgaattaacc ttctatcttt atgcacaaaa acatatattt 1461721 tagcaggcat tcaccttttt catcaaaaga gaagcaggaa gaactttgac ccttatatca 1461781 ggaggctgag acttgagtaa aatttatgtg ttagatacga atgtgttatt acaggatcct 1461841 aacgcgatat tttcttttga agaaaatgag gttgtcatcc ctgctgtcgt tttagaagag 1461901 gttgattcaa aaaaacggta tatggacgaa gttgggagga atgcaaggca cgtatctaag 1461961 ctaatcgatg cgctaagaca aaagggcagg ctgcatgagc atgtaccgct tgacaccggc 1462021 ggcacactga gaattgaact gaatcatcgt tcgtttcacc agctgcaaga gatctttatt 1462081 gaaaagacga acgataatcg catattagcc gttgcgaaaa acttaagcct cgaggaagaa 1462141 accaaggaaa atggcaggcc ggttatcctt gtcagtaagg atgtactggt cagggttaaa 1462201 gccgacgcaa tcggactgct tgctgaagat ttcttgaatg accgggttgt ggacaatgat 1462261 gaaatgtaca gcggctataa agatttatat atcagccagc agctgttcag ctctttttac 1462321 gggaaaaatc aaatttcagt aaacgatgtg aaacagcatg cgttttatcc gaatcagttt 1462381 gctttaatga aggatgagct aggagggtcc tcctcggcag tcggaattgc agacaaaacc 1462441 ggaacggtat taaaaagact cgtatttgat gatgaacata tatggggaat caggccgaaa 1462501 aatgtacagc agacaatggc attagagctt ttgctgcggg aagatattcc gcttgtcacc 1462561 ctgatcggca aagcgggaac cggcaaaacg ctcttagctt tggcggcagg gctattacag 1462621 acagaagact tgggaatata taaaaagctg gtcgtcgcaa ggccgattgt tcctgttggc 1462681 aaggacatcg ggtatttgcc aggcgaaaaa gaggaaaagc taaagccttg gatgcagccg 1462741 atttttgaca acttagagtt tctgtttaat gcgaaaaaac caggggagct tgatgctatt 1462801 ttggcgggaa ttggctcaat tcaggtagag gcgctgactt atatcagagg gagaagcatt 1462861 ccagatcaat ttattatcat tgatgaagcg caaaatttga ccaggcatga ggtgaaaacg 1462921 ttgctgacga gagtcggtga gggcagtaaa attgtcttaa tgggcgaccc tgaacaaatt 1462981 gatcacccat atttagacag tctgaacaat ggtttggcct atgtggttga gcggtttaaa 1463041 ggacaaccca tctcaggcag cgtgaagctg ttaaaaggtg agagatcagg tctcgcccag 1463101 cttgcagctg atttgctgta acacttaaat gatttcgatc tcttttacat cggtaatcgg 1463161 ctgtttgtga tgaaccgggt cttcaaagta aatatgcacg gggccgcctt cttgaatcgg 1463221 cttgcctgcc tcactgaaat ggacaatact gttcagagcg gtttccagag aaacggcggc 1463281 ctttcccgaa cttgtgacaa atacacattg tgtcgcagag ctgttcggct cagcattttt 1463341 caggacagtc ccaagtctca ttgcgaaact gccgttcatc agtttttgct tctcatattg 1463401 cttttccgtc tttaatgtag gcggcgcgat tcgcccctct ctgatgacgc gttccggatc 1463461 aaggtcggat tcatccccgg ctgattgtaa atatgtgtct tgactgtccc ctttgcggtc 1463521 aaacgaaaat ttgcgatcat caaaaatcca tacgcttgga tcaatggtaa ttggatatgt 1463581 aacattgcct tttacttgga taacgctcat gatatgaccc ccttctctca aaattataaa 1463641 agttttcgca tgaattgtca ctttgtgtac aaattatgtg tattgaaatg ctgagggaac 1463701 gagggtgttt gcatggtatg ccagcataat gatgagcttg aagccttagt gaaaaaggcg 1463761 aaaaaagtaa cggacaaggg ggaggtagcc agctatattc ccgccttggc aaaagctgat 1463821 aaacacgacc tgtcagtggc gatttattat tccaataatg tttgtctgtc agcaggtgac 1463881 gtagaaaaaa catttacgct tcaaagtata tcgaaagtcc tttcccttgc tttggtgtta 1463941 atggaatacg gcaaagataa ggtcttcagt tatgttggac aggagccgac cggtgatccg 1464001 tttaattcaa ttatcaagct cgaaacagtg aatccgagca agccgttaaa ccctatgatt 1464061 aatgccgggg cattggtagt gacaagtctg ataaggggaa gaacggtaaa agagagactt 1464121 gattatttgc tttcttttat cagaaggctg acaaacaacc aagagattac atactgccgg 1464181 gaagtggctg aatctgaata cagcacttca atgattaatc gggcgatgtg ttattatatg 1464241 aagcagtacg gcatttttga agatgatgta gaggcagtaa tggatttata tacgaagcaa 1464301 tgcgcgattg agatgaacag cttggattta gcgaaaatcg gatctgtatt cgcattgaac 1464361 ggcagacatc cagagactgg ggagcaggtc atctcaaaag atgtcgctag aatttgcaaa 1464421 acgtttatgg tgacgtgcgg aatgtacaat gcaagcgggg aattcgcaat taaggtcgga 1464481 attcctgcga aaagcggcgt atccggcggg ataatgggca tttcgcctta cgatttcggg 1464541 atcggcatat tcggccccgc attagacgaa aaagggaaca gcattgcagg tgtaaagctt 1464601 ttggaaataa tgtctgagat gtacaggctg agtatttttt aatttatgtc atatgcttaa 1464661 atcctcttgc attttctgtt gatacccttt atgataaata gaagaattag gtactcgcct 1464721 ggggaacgga gggatacttt tggcttcaga gatgatagtt gaccatcggc aaaaagcttt 1464781 tgaactctta aaagtggacg ctgagaagat tttgaagctg atccgagtac aaatggataa 1464841 cttaacgatg cctcaatgtc ctctatatga agaggtttta gatactcaaa tgttcgggct 1464901 ttcgagggaa atcgattttg ctgtccgcct gggattggtt gatgaaaaag acggtaaaga 1464961 ccttttatac acattggagc gcgaattgtc tgctttgcat gacgcgttta cagctaaata 1465021 aatgataaaa ctcaaactta ttaacagttt gggttttttt ataaccgcta tttttctctc 1465081 atctcataaa agacggtctt tttttacaca ttccttccga atcgtataga gattcttcgt 1465141 ctcgtttgat aaattgtagt aaaataaaaa agataaatac ataaaaacca tagataatgg 1465201 aagttagaag cagggaagag gatgttatgt taaaaaaaat gctaaaatct tatgattact 1465261 cactgatatt cgcaatcgtt ttattatgcg gattcggttt agtgatggta tacagctcaa 1465321 gcatgattac ggctgtctcc cggtatggag taagcagtaa ttttttcttc atgcggcagc 1465381 tgtttgcttt aattgcgggt ggcgctctat ttattctcat ggcgttgttt ccttataaag 1465441 cactggccca tcaaaagttt cagaagggga tactgcttgt atctgttctt gcgcttatct 1465501 cactgtttgt tttcgggcat gttgccggaa acgcgcagag ctggtttaaa atcggcggaa 1465561 tgagtattca gccgggggag tttgtgaaac tggtcgtgat tttatacctt gcagccgtat 1465621 atgcaaaaaa acaaagttat atcgaccatc tgttaacggg agtagcccct ccggtagtca 1465681 tgacgcttat aatttgtggg ttaattgcca tgcagccaga tttcggtaca gccatgatta 1465741 tagggttaat tgcgacgtgc atgatcttgt gctccggctt cagcggaaag acgctggtga 1465801 ggcttgtgat actgggcgga attgttttca ttttagtcag ccctattatc tatttgaatc 1465861 aggacaaaat tttaactgaa ggccgtttag cgcgttttga gagtcttgaa gacccattta 1465921 agtatgcaaa ttcatcaggt ttgcaagtga tcaattctta ttatgcgatc agctcaggcg 1465981 gcattttcgg cctggggctc ggtgaaagta tccaaaaata cggatatctg cctgaatcac 1466041 acactgactt tattatggct gtcattgctg aagagctcgg catttttggg gtattgtttg 1466101 tgattttctt attgggtttt gtcgtcataa aaggttttta tattgccaga aaatgcgagg 1466161 acccgtttgg aagtcttctg gcgatcggca tttcaagcat gattgccatc cagtcgttta 1466221 ttaaccttgg cggtgtcagc ggattaattc cgattacagg ggttacgctg ccatttatca 1466281 gttacggggg ctcttctttg gtgctgctgc tggggagtat ggggatatta gcgaatatca 1466341 gcatgtttgt gaaatattca gagaataaga aaaagaaaga gcccttggcg ccgaagggaa 1466401 tgaaaaagaa acagctcaaa aaaactgttt atctgtaaaa aacaagtgtg tacaggggaa 1466461 ggatattccg ctatgataga ttatattcca ttcgggtaag ggggagaaaa gtttgtctca 1466521 gcaatcgata caaaaagtat tagtagcaaa caggggagaa attgcaatcc gaatattccg 1466581 ggcgtgtacc gagttgaata ttcgtacagt tgcggtctat tcaaaagaag attccggttc 1466641 ctaccatcgg tacaaagcgg atgaagcata cttggtcggt gaagggaaaa aaccgattga 1466701 tgcttacctg gatattgaag gtatcattga tattgcgaaa agaaacaaag tcgatgcaat 1466761 tcatccggga tacggtttct tatctgaaaa tattcatttt gcgagacgat gtgaagaaga 1466821 aggcatcgta ttcatagggc caaaatccga gcatctcgat atgtttggtg acaaggtaaa 1466881 agcgcgtgag caggcagaaa aagcgggaat ccccgtgatt ccgggaagcg acggtcctgc 1466941 cgaaacgctt gaagccgtcg aacaatttgg acaagctaac ggttatccga tcatcattaa 1467001 agcctcgctt ggcggcggcg gccgcggtat gcggattgtc agatctgaaa gtgaagttaa 1467061 agaagcatat gagcgtgcta aatcagaggc gaaagcagcc tttggcaatg atgaagttta 1467121 tgtagaaaaa ttaattgaga atccgaaaca tattgaggtt caggtcattg gagacaagca 1467181 gggcaatgtc gtccatcttt ttgagaggga ttgctccgtt caaagacgcc atcaaaaagt 1467241 cattgaagtg gcgccgagtg tctcgctgtc acctgaatta agggaccaaa tttgtgaggc 1467301 tgcagttgcg cttgccaaaa atgtaaacta tataaatgcg gggacggtcg aattccttgt 1467361 tgcaaacaac gagttctact ttattgaagt aaatcctcgc gtacaagttg aacacacgat 1467421 aacagaaatg attactggtg tcgatattgt tcaaactcag atccttgttg cccaagggca 1467481 cagccttcac agcaaaaaag taaatattcc tgagcaaaag gacattttta caatcggcta 1467541 tgccattcag tcacgggtta cgactgagga tccgcaaaat gatttcatgc ctgatacagg 1467601 aaaaatcatg gcttaccgct caggcggcgg ttttggtgtc cgtcttgata ccggaaacag 1467661 cttccagggc gccgtgatca caccatacta tgattcactt ctcgttaagc tttcaacttg 1467721 ggctttaacg tttgaacagg cagctgccaa aatggtgcga aaccttcagg agtttagaat 1467781 cagaggcata aaaacgaaca ttccgttcct tgagaacgtt gcaaagcatg agaagttcct 1467841 gacagggcaa tatgatacat ctttcattga tacaacgcct gaattattta atttccctaa 1467901 acaaaaagac cgcggaacga aaatgctcac ttacatcggc aatgtgacag tgaacggctt 1467961 ccctggaatc gggaaaaaag aaaaaccggc gtttgacaaa ccgttaggcg taaaggtaga 1468021 cgttgatcag cagcctgcca gaggaacaaa gcaaattctc gatgaaaaag gtgcagaagg 1468081 gcttgcaaat tgggttaagg agcagaaatc tgtcctttta actgatacga cattcaggga 1468141 tgcccaccaa tcgttattgg caactagaat cagatcgcat gatttgaaaa aaatcgcaaa 1468201 tccgacggct gcgttatggc ctgaactatt cagtatggaa atgtggggag gcgcgacctt 1468261 cgatgtagcc taccgattcc tgaaagaaga tccgtggaaa cgtttggaag atcttcgcaa 1468321 agaagtgccg aataccttat tccagatgtt gcttcgctca tcaaatgcgg tcggctatac 1468381 gaattatccg gacaatgtga ttaaagaatt tgtgaagcaa tcagctcaat ccggtattga 1468441 tgtgtttcgt attttcgaca gcttaaactg ggtaaaaggg atgacgttag ccattgatgc 1468501 tgttagggat accggcaaag tggcagaagc tgcgatttgt tatacgggag atatccttga 1468561 caagaaccgg acgaagtacg accttgcata ttatacatcg atggcgaagg agcttgaggc 1468621 ggccggagcc catattctcg ggattaaaga tatggcaggg ctgttaaaac cgcaggctgc 1468681 atatgagctc gtttctgcgt tgaaagaaac gatcgacatt ccggttcacc ttcatacgca 1468741 tgatacgagc ggaaacggta tttatatgta tgcgaaagct gttgaagccg gcgttgatat 1468801 catagacgtg gcggtcagct caatggcggg attaacgtca cagcctagcg cgagcggatt 1468861 ttatcatgcg atggaaggca acgaccgccg tccggaaatg aatgtccaag gcgttgaatt 1468921 gctgtcccaa tattgggagt cggtgcgtaa atattatagt gaatttgaaa gcggaatgaa 1468981 gtctccgcat actgaaattt atgaacacga aatgccaggg ggccaataca gcaacctgca 1469041 gcagcaagcc aagggagtag gccttggcga ccgctggaac gaagtcaagg aaatgtacag 1469101 acgcgtgaac gatatgttcg gtgacatcgt caaggtaacg ccttcctcaa aagtagtcgg 1469161 agatatggca ctctacatgg tgcaaaacaa tctgactgaa aaagacgttt acgaaaaagg 1469221 tgaatcttta gatttccctg attctgtcgt ggagcttttt aaaggaaata tcggccagcc 1469281 tcatggcgga ttcccagaaa aactgcaaaa gctgatctta aaagggcagg agccgattac 1469341 agtcagaccg ggcgaactgc ttgagccggt gtcatttgaa gcgatcaaac aggaatttaa 1469401 agagcagcat aacttggaaa tttcagatca ggatgctgtg gcatatgccc tttatcctaa 1469461 agtcttcact gattatgtga aaacgacaga aagctatgga gacatctcgg tattagatac 1469521 accgacattc ttctacggta tgacattagg tgaagagata gaagttgaaa ttgagcgcgg 1469581 caaaacgctg atcgttaagc tgatttcaat cggtgagcct cagcctgatg ccacccgcgt 1469641 cgtttatttc gaactcaacg ggcagccgcg tgaagtagtc attaaagatg aaagcattaa 1469701 gtcttccgtt caggaaaggc tgaaagcaga ccggacaaat ccaagccaca tcgcagcttc 1469761 catgcctgga acagttatta aggtattggc tgaagcaggc acaaaagtca ataaaggtga 1469821 tcatttgatg attaatgaag cgatgaaaat ggaaacaacg gttcaggcgc ctttctcagg 1469881 aacaatcaag caggttcatg tgaaaaatgg tgagccgatc caaacgggag atctgctcct 1469941 tgaaattgaa aaagcataaa aaacaaagag tgtatatcaa tgatatacac tcttgttttt 1470001 tatatagaaa atgtggagtg aaacagatgg ttagaagaga tataagggga cttcagagat 1470061 tatagagtac tgtcacaagc ccaaaataaa aagaggctta tacagccaat attttagatg 1470121 ctttgtagta tgccgtgcat atttctttaa gcactatctg atttaaaagg ctttaatact 1470181 tatgttcgcg agctatagat ccatatgaaa tttctataat cacgatgaga aaggggacag 1470241 accgaagtga gccgctcact gatcatcaag ttcggcgaag gctggcgatt gaaacgcata 1470301 aagcgccaaa aaacaagaca taaaaaagac caaagccgcc taaggctttg gtcttgagtc 1470361 cttatgattg cctggattca taacggaaac gagcaatcaa taataagaag tagcatagaa 1470421 cgccaaacag acaggcaata aagaacgagt gggcaagtgc aaagcccaga gccagttcag 1470481 agtatacgat cataataccg gacagtgcct gtaatgtaat gaaaataaga catgagatcc 1470541 atccccaaaa gatctgtttt tgatctttat aggaagtaat agcatgaaca gcggcaacaa 1470601 taatccatac aaataaaagt aaggctgctg ctctgtggcc catttgcacc cattcatgga 1470661 attgggtcgg aagtccattg ttcagcgggc tgcacagcgg cacattagga catgccagac 1470721 ttgattcagt gtgtcttaca tatgcgcctg tatacacaac gatataggaa tatattaaaa 1470781 ttcctatcat gtgaaattgc atctttttgc cgatttgaag cggcttaacc agtgttctga 1470841 ctgatttatc agcttcaaat atgagcaatg ttaaaataag cactgaagca aaagaaatta 1470901 atgagatgcc gaagtgaagc gccataatca gcgcgttcga accgaatacg acagccaatg 1470961 cgccaagcaa tgcctgaaga aataaaaaga taattgacat gatcgcgaga aacgttgttt 1471021 cacgaaaaat cggcgtgatt tttctccatg accaaaacgc aaggcttagc acaaggataa 1471081 tagagattcc gcttgcgaat cggtggctcc attcaataat tgaagccgga ttcagttcag 1471141 ggaaaaaacg gccgtgacac agcggccact gtctgccgca tccttggccg gaacctgttt 1471201 ttgtaacgag ggcacccccg attaaaacaa ttagcatgac aaatgtcgtc agaacaccga 1471261 gagcttttaa tgctttattc atacaatatt caccttctta acatactgct gcaattttat 1471321 atacgttcca agtgtaagcg aatatgtgtt ttgtggcaat tcccagagcc ttttgttcac 1471381 aaaaatataa tagaatgacg gcttctggaa aatgtacact tgattattca tgccgggtct 1471441 gatagaaata aggtaaacgc aatgccgatt tggagattgc cttcatcttt ggtaaaattc 1471501 ataaaaagtt cacaaataaa ttcctgtttg tcgtttaata tttaatagga tgttttttta 1471561 caagatgtta tcttgtatga tagagttgca ggttatttta ttctcctgcg ttaggtttgt 1471621 aagggaggtt tacgttatgg ctaactccag aatcttaaat gatacagcta tagacggaca 1471681 aattgaagaa acaacggcat ggaaagattt tctgtccctt attaaaatag ggatcgtcaa 1471741 ttctaacctc atcacgactt tcactggaat gtggcttgca ctgcatatat ccggtttaag 1471801 ttttttaggc aatataaaca ccgttcttct tacgttaatc gggtcttcac tgattattgc 1471861 gggctcctgc gcgatcaata actggtatga ccgggacatt gaccatctta tggagcgtac 1471921 gaaagtaaga ccgacggtta cgggtaaaat tcagccgagt caggcgttat ggtctggaat 1471981 tttgctggtt gctttaggat tgatcatgct gctgatgaca actgtcatgg ctgctgttat 1472041 cggttttatc ggagtcttta cgtatgttgt attgtacaca atgtggacga aacgccgcta 1472101 tacgattaac acagtagtag gaagcgtttc cggtgcagtg ccgccgctta ttggatggac 1472161 ggcagtggaa gggaatatcg gtgtcgtagc atgggtgtta ttcatgattt tatttatttg 1472221 gcagattcct cacttcttag cattggctat taagaaaact gaggattaca gagctgcaaa 1472281 tattccgatg cttcctgtcg tatacggatt tgaagtgaca aaaagacaaa ttattgtgtg 1472341 ggttgcgtgc ctgatgccgc ttccgttttt ccttggtagc ctgggtcttc cgattgtcat 1472401 tctcggcttg ctgttaaata tcggctggct gattcttggc ttaatgggat tccgctccaa 1472461 gaatatcatg aagtgggcaa cgcagatgtt cgtttactcg cttaactaca tgacaatcta 1472521 tttcgttgcc atggttgtct tgacgctttt ctaaaaaata gatatgatgc ttgttttatc 1472581 gcttcaaaat aaacgatgac aactagtaaa tgccgccttg acctcttgtt taatcaggcg 1472641 gctttacttt tatacataga tggcattttg agtaaaaaaa ctcataattt aagagaagag 1472701 gaaatgtaag tgctttattg gtgataggtt ggatggcgat agatttcgat ccgctttccg 1472761 cctttgtatt gaccagaaaa ggggttgggt gaaatggtaa agcattggcg tcttatttta 1472821 ttattagcct tagtgccgct tctattaagc ggatgtggaa aacctttttt atccacgctc 1472881 aagcctgctg gcgaggtggc tgataaacag tatgacctga cagtgctcag cacattgatt 1472941 atggtggttg ttgttgcagt agtatctgtt atcttctttt atgtgattgt gagattcaga 1473001 agatcacggg tcggtgagaa cacgataccg aaacaggtag aggggaataa atttttagaa 1473061 atcacatgga ccgtgatccc gattttgctg ctcattattc ttgtgattcc tgttgtatta 1473121 tatacgctgg agctagcgga cacatcacca atggataaaa aaggccgcaa agctgaggat 1473181 gctcttgtag tcaatgttag ggcaaattta tactggtggg agtttgagta ccctgattac 1473241 ggcattatca caagccagga gctgattgta ccgacagatc agcgtgtata ttttaattta 1473301 aaagcctctg atgtaaaaca ttccttctgg attccttcag ttggaggaaa acttgatacg 1473361 aatacggata atgaaaataa gttcttcctg acatttgatt caaaacgaag caaagaggca 1473421 ggagatatgt tttttgggaa gtgtgcagag ctttgcggcc cttcacatgc gctgatggat 1473481 tttaaggtga agacgatgtc tgcaaaagaa tttcagggct ggacaaaaga aatgaagaac 1473541 tataagtcta cagcagagag cgatttggct aagcagggtg aagaactgtt taaagagaaa 1473601 aactgcctga gctgccatgc ggtagagccg aatgataagc gtgcagaagc cgctagaacg 1473661 gcacctaact tggcgacctt cggtgaaagg acaaaagtgg caggggtgaa agaggccaac 1473721 aaagaaaatg tgaaggcttg gctgaaggac cctgacagca taaagccggg gaacaaaatg 1473781 acaggcacat atccaaagct ctcagacagc gaaacaaatg cgctttatga atacttaaaa 1473841 ggcttaaaag cggaaagcaa gtagggaaga aagggagata ttgggggagg tcacatatgt 1473901 tgaatgcgct tacagaaaag cggacgcgcg gatctatgct ttgggattat ttgacgacgg 1473961 tggaccataa aaaaatcgca attctttatt tagtggcagg gggattcttc tttcttgtcg 1474021 ggggaattga agcgatgttt atcagaattc agcttgcaaa gccggaaaat gcgtttctca 1474081 gtgctcaagc gtacaatgaa gtaatgacta tgcacggaac gacgatgatc tttctggctg 1474141 cgatgccgct cttatttgcc ttgatgaatg cggttgtgcc tttgcagatc ggggctcggg 1474201 acgtttcgtt tccattttta aacgcgcttg gtttttggct cttctttttc gggggcattt 1474261 tcttaaatct aagctggttt ttgggcggag cgccagatgc gggctggaca tcatatgcct 1474321 cactttcgct tcattctaaa gggcacggca tagacttttt cgtcctcgga ctccaaatat 1474381 cggggctcgg gacgctgata gccgggatta actttttggc cacgattatc aacatgaggg 1474441 ctccgggcat gacgtatatg aggctgcctt tgtttacatg gacgacattt gtggcctcgg 1474501 cattgatttt gttcgcgttt ccgccgctta cggttggatt ggctctcatg atgctggatc 1474561 ggctgttcgg aaccaatttc tttaatccgg agcttggcgg aaatacggtc atttgggaac 1474621 atttattttg gatcttcggc cacccggagg tttatatcct aattttgcct gcattcggta 1474681 ttttttctga ggtcatccct gtgttcgcca gaaagcgttt gtttggctat tcttcaatgg 1474741 tttttgcaat cgtgctcatt ggctttctgg gctttatggt ttgggtgcac cacatgttca 1474801 cgactggtct cggcccgatt gcaaatgcga tttttgcggt tgcaacaatg gctatcgcga 1474861 ttccgaccgg gattaagatt tttaactggc tgttgacgat ttggggagga aatgtgaagt 1474921 atacaaccgc tatgctgtat gctgtctcat ttattccatc ctttgtgctc ggcggtgtga 1474981 cgggagtcat gctggcagct gctgcggctg attatcagtt tcatgatacg tattttgtgg 1475041 ttgcgcactt ccactacgtc attattggcg gcgttgtatt cggcctttta gccggtgttc 1475101 atttctggtg gccgaaaatg ttcggtaaaa ttctgcatga aacgatgggg aaaatttcat 1475161 ttgtattgtt ttttatcggc tttcacctca cgtttttcat tcagcatttt gtcggcttaa 1475221 tggggatgcc gcgccgggtt tatacgtttt tgccaggaca gggtctggaa accggcaact 1475281 tgatcagtac aatcggggcg ttttttatgg cggcagctgt tattcttctg ctggtcaatg 1475341 tcatatggac atcggtaaaa ggtgaatatg taggtgctga tccatggcat gacggacgta 1475401 cgctggaatg gaccgtttct tcaccgccgc cggagtataa ctttaaacag cttccttttg 1475461 tcagaggact tgatccgctt tggatcgaga agcaggcagg gcacaaatca atgacgccgg 1475521 cggaaccggt tgatgatatt catatgccaa acggctcaat cctgccgctc atcatttcct 1475581 tcggcctttt tgtcgcagcg ttcgggctgc tgtacagaag tgattacgct tggggcctgc 1475641 cggtgatctt tatcgggctc ggcatcacat ttattacgat gctgcttcgt tcagtaattg 1475701 atgatcacgg ctatcatatt cataaagagg aactgccgaa cgatgataaa ggggtgaagg 1475761 cataatgcaa gttcaagaaa aattcaccgc agaaaccttt ccagcttctc ctgaaaaagt 1475821 aaccctggaa gggaaaaata aatttttagg cttttggctt tttcttggcg gagagactgt 1475881 tctgtttgcg tctctcttcg ccacgtttct tgcgcttcgg aattcaaatg ccggtgatcc 1475941 gcctacgacg gaaatgttcg atgtgacact tgtattcatt gccacaatgc ttctattaac 1476001 gagcagttta acgagtgtgt acgcgatgta ccacatgaag aacttttcct tcggcaagat 1476061 gcagctttgg ctgggaatta cgattttatt gggggcgggc tttttaggac tggaaatcta 1476121 tgagttcaag cattacaccc atgaatttgg ctttaccatc acaagctctg cccttggttc 1476181 tgcgttttac acgcttgtcg gtacacacgg cgcccacgtg gcatttgggc ttatgtggat 1476241 cagcacgctt atgatccgca atgccaagag agggctgaat ctgtatacgg cgcctaagtt 1476301 ttacgttgcc agcctttatt ggcactttat tgatgtcgtg tgggtcttca tctttaccgt 1476361 tgtatattta atggggatgg tgggataaac atggtcgata aaaaaagcag agggcatatc 1476421 aatagcgacc ttgaatttaa gaaaaaaaag catgcccggg agatgaaata tcaagtcctg 1476481 tcttttggtt taatgatcgg tcttacgatt gttgcatttc tgactgtggc cacggacggt 1476541 gtcggcagct ggtttacgat tcctttcatt attttgctag ctgcaattca agtcattttt 1476601 cagctgtatt atttcatgca tatgaatcag aaagggcatg aggcgccggc actgtttttg 1476661 tattcagggg tgtttgtcgc gtttatcact gtgcttgcgt ttgtgacaat tatatggtgg 1476721 taatttgaac agccgccgga ggtgaagaaa tgaatcagtt ggagatattt gggtttcgcg 1476781 cgatgtggag cccttatctt ttttgtatcc tgttaggcat tacggcgctt tatctctatt 1476841 tttacaggcg aatgtcttca aagccgaatc gaataactgg taaagagatg gtgtgctttc 1476901 tgtcggcgat gctgttttta tatgcagccg agggaagccc ggttgatctg ctcggacata 1476961 ttatgttcag tgcgcatatg gtgcagatgg ccgtcctgta tttggttgtc ccgccgctgt 1477021 taatcgcggg gattcctgca tggctctggg aaaaaatcat tttcaggcct tcaatcaaac 1477081 cggttttttc cttttttacg acgcctttaa ttgctttgct tttgtttaac ggcatttttt 1477141 ctttatatca tgtaccgctt atatttgata ctgtcaaaac agatccgttt taccatacat 1477201 taatcacttg gcttatcttt gtgcttgcgt tcttcatgtg gtggccgctt gttcataagg 1477261 ttgagcgtct acggcagctc agcggcttga tgaagctggg ttatattatg gcggacggta 1477321 tgctgctcac acctgcttgc gccttgatca tgttcagcgg tgcaccgtta tacgccacct 1477381 atacagatcc ggctttatgg gctgaggcaa tgaggctttg cgtgccagcg gatatgatgg 1477441 ggcaggtccc attaacaggg ccagagatgt tgaatacact gcctttgtta gaggatcagc 1477501 agctcggagc agtcatgatg aaaatcattc aggaaattgt gtacggtact tttttggccg 1477561 ttattttttt ccaatgggtg aagaaagaaa gggaaaagga cgggcaggag gagccgccgt 1477621 atattcagca gacgatatca taaaaggtac agcgaaatat gctgtacctt ttcgttacat 1477681 ttgaactgtt tttaacatgt tggctatgtc ctgaatcagt gccttgcttt ttgtcacaac 1477741 ctgtacggga aactcttccg tttctccata ttctactcca tgagggtagt aatgctttcc 1477801 taggagaggg gacattaatt gaatcacggc gcgcccgctt ccgacatcgc cttctgccgc 1477861 aataccttgt atccgcaggt aaaacgtacc ctcaatcgtc gaaaacttct tgtcataggt 1477921 gactctctcg taatcccatt gacccgctct gataagacct ttgctttcca ttaagtcgtc 1477981 tagccagctg agctcagcct taaccccttc aagtccgctt tcagtaaact tcaacactga 1478041 cccctcctta taaaaattac ctttcctgac aatcatagta tgaaagcgtt aaactttcaa 1478101 tgaatcttct tcttttgaaa gtatgcaaaa attaaatttt gacgacaata gcactagact 1478161 aaaggaggtt aaacggatga caaaaataaa agatctgatg acagccgact tgcaatattg 1478221 cacggtatta gataatgtat atgaagctgc agtaaagatg aaggacgcaa atgtaggagc 1478281 gataccggta gttgatgagg acggggaaac attggtcggc atcgtaaccg accgcgatct 1478341 cgtattaaga ggaatcgcca tcaaaaaacc gaactcgcaa aaaatcactg acgcgatgac 1478401 tgaaaaacct gtcagtgtgg aggaagatgc ttcagtcgat gaggttcttc atttgatggc 1478461 atcgcatcag ctcagaagga taccagttac aaaaaataaa aaactgactg gaattgtcac 1478521 gcttggtgat ctttctttat ctgagcaaac gaatgaacgt gccggcagcg ccttatcgga 1478581 tatttccgaa ggggataata gagaagaagg cttttttcat taacacataa atctttgaca 1478641 tgttaaatag gctgtattgt aatgggatgt aaacaagaga ttgtgaatcg ccacgggggt 1478701 gatagattga aaaatatatt gagagcaatg gttatccttt tgattatctg cggaacctat 1478761 gttctgttta ttcaatatgg atctgttcct gaaaagaaat caaatgacag cgagcctcag 1478821 gtgtcgaatg aggaagcgca aagcggcaaa cgaatacata tgccgacttc agggttattg 1478881 tccttcatgg gcaagcacgc cgatgaagta acgaaaaagc ttggggaacc tgaacgtatt 1478941 gacccttcgg cttatgatta cgattggtgg gtatacaatc aaggtaagga tcaatatatc 1479001 caaatcgggg tattaaacaa taaagtggtc acattattcg cgtcgggtaa tgatattaac 1479061 gccaagcctt tcaaaattgg agaatcaact ggcgaagtat tcaagaccac ccaggtggca 1479121 ccatttgtga atgtagagta taaaggaaat tcctatcggt ttgaattttc tgaagaagat 1479181 atcaatacaa gaccgactgt aaaggtagga aagatgtatg tccagctgta tatggacaaa 1479241 tttgagggga agctatccag catcagggcg tttgatgcgc agacctttgt aaagcaaaga 1479301 ccttatgagg tagtgtaccg cggggaatta attaaaccga aagccgtttc agatgagaaa 1479361 tggaaaaaga tccaaacaac gagcgaaaag caaatccttg atttgacgaa tgtcatacgc 1479421 gttaaacatg gacttgcgaa gcttgagtgg gatcagccaa cggcggaagt ggcatttggg 1479481 catagtgagg atatgaagga aaataattat ttctcccatg tctctaaaaa atacggctcg 1479541 ctgaaagacc gcttagaaga agggcatgtt gattttcagc aagcgggaga aaatatcgca 1479601 tacaattatg tggacggtcc ggctgctgta gaaggctggc tgaatagcga aggccatcga 1479661 aaagcgcttc tgaattcaga ttatacgcat cttggtgtcg gagtagaccg gaaatattac 1479721 acccaaaact ttattaagcg atggtaatga aagccgcgga cgaatggttc ccggcttttt 1479781 ctatttccat acaagctggt ctgaatgaat gtgctgatag cttacagata aggccgtttc 1479841 ccatcccttc agtcaggctt tttcaccagt gtatagggat atcgctaaaa attcatttgg 1479901 gaatgaatat aggcgaacac aatgcccgac aaaacgatac attgtagtag gtaacgattt 1479961 tcggaggggg tgaggattgt ggcgaatcaa catgccaatc attcaatcaa tgactttaaa 1480021 caattcgtca aaaagcatcc caagctgata aaagaagtgc gcaaagaaca aagaagctgg 1480081 caggacgtat atgaaaattg ggtcctcttc ggggagagcg acccgatttg ggatccatat 1480141 cgggaaccgg aagaagcttc tgaagctgtg cctgaaacac cgcaaaaaaa tgattttgtc 1480201 tcgaaaatgg tgacagcggt gaaaaagatg gatgtcaatc aaatgaacga acaaatcaat 1480261 aaaatgagcc agtcgatctc atcgttgcaa agccttctta atacattttc cggaagcgga 1480321 cagaagcatt ctcagccagg ctctggacag catccttttt cttttcgaaa ggattaaaaa 1480381 aggggagctc atatgcgcaa agaggttcag gaatatattt tagcaaacga agaacggaaa 1480441 cgattcatca gagaacagcc gatatggtac cgcaggcttt caagaaaacc ggatgatctg 1480501 tcctcctttc agcttgaaat gatgaatttt tatgaaaaaa ccattccgca tcgggtgaat 1480561 cagtttacga acgggattca aatggcgcaa atgatgatgc aaatgtttca agcgatgcgg 1480621 acaaaagatt aaaaggcccc gaagaagggt cttttttcat gcggtcataa ggttttgttg 1480681 gcggctgcgg ttaagcattt tccaattggc tggtttcatg gtaaactaac aactggaggt 1480741 gcatgttatg tatgcgacga tggaatccgt gcggcttcaa agtgaagctc agcagcttgc 1480801 cgagatgatt ctgcagtcgg agacggctga gaactaccgc aattgttaca agcgtctcca 1480861 ggaagatgaa gaggcaggtc ggattattcg ttcttttatc aaaataaaag agcagtatga 1480921 ggatgtacag cgttttggca aatatcatcc tgactataga gaaatatccc ggaaaatgag 1480981 ggagatcaaa cgtgagctgg acctgaacga taaggtggct gacttcaaga gagctgaaaa 1481041 tgagctccag tccattcttg atgaggtcag cgttgagatt gggacagctg tttcggagca 1481101 tgtgaaagtt ccgactggga acccttattt tgacggtttg tcttcatgcg gaggcggctg 1481161 cggttcaggc ggaagctgcg gatgtaaagt gtcctgacga gactggccgt ctcgtctttt 1481221 acatataaga gaaaacaggc aggtgattgt attggagaat aggcgccagg gcatggttgt 1481281 gtatctgcac tccctaaagc agagcaaaat gctgaggaag ttcgggaatg tgcactatgt 1481341 atcaaaacga ttaaaatatg tcgtactgta ctgtgatatg gaccaaattg aaaaaacaat 1481401 ggacaagatt gcgtcttact catttgtgaa aaaagtggag ccttcttata aaccgttttt 1481461 aaaattggaa ttcgagtcaa agcttgataa ggcaaaagaa tacgattata aaatcggcat 1481521 atagctataa aaaaatcccc gcaggcatct gcggggtcct tctattcctt aatatgttaa 1481581 ggagaaggca aagggagagg agaaaccgga ggaagaactt atggggaaac gtaagtcttc 1481641 tccgcggttg gcaacaacat cctctagatg ctgttgctta tagtatggac aaggatcatg 1481701 ctgcctatac acctgtttat caagattagc gttcattgtt tggaagaatg ctttatgtta 1481761 agataggatt gatttttttc tatgtacata gcggcgtccg gccgaataaa gaaacaaaat 1481821 agcttttaga aaaagtggtg tggaacatga gagtaatttc tggatcaaaa aaaggccgtt 1481881 cactaaaggc tgtagccgga acatcaacaa gaccgacaac cgacaaagtg aaggaatcca 1481941 ttttcaatat gatcggccct tattttgacg ggggcagggg acttgactta ttcgcaggga 1482001 gcggaggtct tggaatcgaa gcgctttcac gcgggtttga gcattgtata ttcgttgacc 1482061 gtgattttaa agcgattcaa acggtaaaat ctaatttgaa aacgctggag cttacaaaac 1482121 atgcacaggt ataccgcaat gatgcggaac gtgctttgca cgctgctgct aaaagagaaa 1482181 ccggctttcg cggaattttt ctcgatccgc cgtataagga acaaaagctg aaagcacttt 1482241 taactttgat tgacgaatat caaatgctgg aagaagacgg ctttatcgtc gctgagcatg 1482301 acagagaggt cgagcttccc gaaaccgtag gagatcttgt gatgacaaga aaagaaacct 1482361 atgggttaac aggtgtagcg atttataaaa agagggggta gtgaggtggc gagtatagct 1482421 gtctgtcccg gcagttttga tcctgtgacc tacgggcatc tggacatcat caaacgcggg 1482481 gcgcatattt ttgaacaagt gtatgtatgt gtgctgaata attcttcaaa aaagcctttg 1482541 ttcagtgtgg aagaacggtg tgagcttctg agagaagtca caaaagacat tccgaacata 1482601 acagttgaaa catcgcaagg cctgttaatt gattatgcaa aaagaaaaaa tgcgaaagcg 1482661 attttaagag gcttgagagc tgtatctgat tttgaatacg agatgcaggg gacatcagta 1482721 aaccgggtgc ttgatgaatc tattgagacg ttttttatga tgacaaacaa tcaatattcg 1482781 tttctaagtt caagcatcgt aaaagaagtg gcaagataca acggctcggt atcagagttt 1482841 gtaccgccgg aagtagagtt ggcgcttcag caaaaattca gacaaggatg agggttttga 1482901 ctcatccttt ttttgttccg tttgtcagtc tgtaagaaaa aatgataatg tacgtaaaca 1482961 gcgcgcatag tgtgacagca ggtccgatct gcacaagcag attccagccg tttataaagg 1483021 cagttgacat gtcactgctg ttaagagatt taaatacata ctgatacgga tcatgccatg 1483081 ctgtgtaaag aggtttccat aaaagcatga cgaagacagc ggcataaacg ccctgcagca 1483141 aacgtgcgat aaagaatggt ttaaatctaa tgtcggtttc cgataaaata cctgccacct 1483201 gagcttgtac ggaaaagccg ctaaacccaa gaataaagct gacgataatg gctttttgca 1483261 gaagagaaac atctgtctcg ctgacaagct tgctgcctaa tgtaatttca aacatccctg 1483321 ataaaagcgg aatgtccaat tgagtcggaa gctgaaacaa agtcagtgct ccttttgtga 1483381 aaacagacaa aacatcagtc agctggacca ctgacaacag ccgattgaag acagaaaata 1483441 aaataataaa gccgcctacc ataagaagcg tttgaacaga agacgtcacg gcgtcgccta 1483501 aaattttacc taagggccgt ttttctgcaa gtctggcggt atgaagagcg tgtaaagcat 1483561 ctttgactga agggaaaggt atcgttttct ttcttctgag atgctgctct tccttgcggc 1483621 cataggagcg cattgttaaa ccgacggcaa gattccccaa atagtgtgca gaagctaata 1483681 aaatgcctag tgatgcgttt tgaaagaaac cgacggcaac agcgccgaaa ataaagagcg 1483741 ggtttgaaga attggtaaac gacgcgagcc gttctgcctc tactcttgaa atctgatttt 1483801 cctgccgcag acgggcagtg agttttgcgc ccgctgggtt tcctgatgcc attcccatag 1483861 caagaacgaa gccgccgaca cccggcacgc gaaagatcgg ccgcataaaa ggctcaagca 1483921 aaacaccgac aaaccgcaca atgccaaagc cgattaagag ttcggacaga ataaaaaatg 1483981 gcagcaatga cggaaacaca acctcccacc acatagacag cccggtttta gaggcttcga 1484041 atgaggcctg tggatgtgag atgacagtcg ctgttaaaaa aagaaaaaac gaggcaatca 1484101 aaagtgtatt aatcttcgac aagttcattc ttacctcccc gatgctaaaa atgcccaatg 1484161 acatgtatat catgataaaa taatgtatga tgtaaaacgg ccaagcagta cctgtcctct 1484221 tgattctttg tactaatata cgagcatagg ggttcagttt agaccataga attcggtata 1484281 cagggaattc aggcaggagg ttaacgcttt ggccaaacct aaaatcgggt tagcgttagg 1484341 atcgggaggg gccagagggc ttgctcatct cggtgtgctt tccagtttac ataagcacca 1484401 aattgaagtg gatatgattg caggaagcag catgggcgct ttggtgggca gtttttacgc 1484461 cgccggacat gacgtggcaa cgatgaaaaa agtagccaaa gcctttaaac gaaggcttta 1484521 tgctgattat acggtgccga aactcggttt tttaaaaggt gaccgcgtca gacagcttgt 1484581 gcatgcttat acattcggaa aaccgattga agagctccaa atcccgctgg gcattgttgc 1484641 gtgtgatcta cagacgggag aaaagattgt gttccgaaaa ggatcagtgt cagatgcagt 1484701 gagggccagc atcagcatcc cgggtatctt tattccgcag cggctggacg gacgccttct 1484761 tgtagacggc gcggtcgtcg atcgaattcc ggtttctgtt gtgaaagaca tgggagctga 1484821 tattatcatc gcttcggatg tttccagggt tcgaaaaact gaaacagcag tgcatatttt 1484881 tgatgtgatt atgcaaagta tggatatact gcaaaatgaa ttagtgcggc atcaaacaat 1484941 tgccgcagat atcatgattc gcccttccct tgaaacatac agctcaagct cgtttgccaa 1485001 tattgaagaa atgatatcgg caggcgaaga ggcgacaaac cgaatgatca gcaagataag 1485061 aaaagaaata gagaattggg agggctcata atttgctacg taaaaaacat tttagctgga 1485121 tgctcgtcat cctcatactg atcgccgttt tatcatttat aaaacttcca tactatatta 1485181 caaaaccggg agaagcgaca gagcttgctt cattgataaa agtggaggga ggctacccgg 1485241 aaaaaggaag tctgtcctta atgactgtta aagtgggacc ggctaatcca tttacatatg 1485301 tgtgggcaaa gatgcaccct tattatgaaa ttgttcctga tgagagcatt aaggaggaag 1485361 gcgaatcaga taaggagtat atgaaaagac agctccaaat gatgaaaagc tcgcaagaaa 1485421 atgcggttat agccgcctat caaaaggcag gaaaaaaagt cagctattcc tttaacggca 1485481 tatacgcaag ctcagttgta gaaaacatgc cggcaaaagg gaaaatagaa gtcggtgata 1485541 aaatcatcag cgcagacggc aaaaactatc agtctgctga aaagctgatt gattatatca 1485601 gcagcaaaaa agcgggagat aaagtcacgt taaagatcga aagagaagaa aaagaaaagc 1485661 gtgtcaccct tacgttaaaa caatttcctg atgagccgga tcgggcagga atcggagttt 1485721 cgctttatac agacagaaac gtgaaggtag agcctgatat tgattttgaa atcgaaaata 1485781 ttggcggccc gtcagcaggg ttaatgatgt cccttgaaat ctataatcag ctgacaaaac 1485841 cagacgaaac aaaaggctac gatattgcgg gaacaggtac gattgatgtt gacggaaaag 1485901 taggcccgat cggcggcatt gatcaaaaag tcgtcgccgc agacaaagcc ggaaaagaca 1485961 ttttcttcgc gccaaatcaa aacggcgcca gcaattccga ttataagaac gcagtaaaaa 1486021 cagcaaaaga tattgattca aatatgaaga ttgtgcctgt tgataccatg caggatgcga 1486081 ttgattattt gaataagctg aaagcgaaaa gcacctgatt ctcaggtgct ttttctatac 1486141 atttaaaaag tgttgttcat cttcgtcata tcgaatcggt gcatgtccgt attcctgtag 1486201 gtcaaactca gttctcagcg gctcttctat cggcaggctg taaatcctgc ttgcttttac 1486261 gtccagatcg agagctggat gggagaaaga ggacagtttg ctgacaagcg gaacagacag 1486321 tgcttttttc ttttcggata aataagcctg tccttttttc gtcatgccga gaagcctgat 1486381 atacggcgcc ttatcgttgt caagcagctt ttgcatatcc tgtttttttg ttctggttaa 1486441 aatgtgtgta ttcatccgct ggagccttgt ccacgtatag cgttttgttt tcagcagttc 1486501 cataaattcc tgataggagc tggattttct gatcgaacga ataattctgt gctctaaacc 1486561 ttcctccacc tcgtatactt gctgtaattc ccgtgccgtt acagttgaaa ggctgtattt 1486621 taagtaagaa aagtagcttt caggtgtatg ccacaatccg aaagatttgc ggtaagctgc 1486681 taattcacgt gcagatgcag cagggagaaa acgaaggcag gcttcgagat tctggccaat 1486741 catcgctttt ctaatgcttg tggcacttgc tatatggttt tcgccttcag ggagatcggc 1486801 atcatgatag tccgaagaga ttcgtgccgt agtataaggt ttcataggat atcccccggt 1486861 tagaatcgag gtcacatact ggtatcccaa aatgttattt ggttttgaca agtcaagtgc 1486921 actttcagta tgcaaaatgg agctgaaggc gatagccgcc gctgctgggt aactggcccc 1486981 ctttttaagt tcttctttaa ttcggtcatt caatatatgt ttatgctcat caataagctg 1487041 tgctgtttct aaaaaaggct tgatatcccc attttcactc ccgaaaaaca gcgcctcaca 1487101 ttcaagttcg ttcaggatgg aaacactgcc gcgtgcaaaa atgtctgctt tttgcacggc 1487161 ataaagataa ggcagctcaa tgacaagatc aactccgctt tgcagcgcca tttttgttcg 1487221 ggcccatttt gatacaacag cgggttcccc gcgctgtaaa aaatgtccgc tcatgaccgc 1487281 gacagccgtg tcacatccgg tttgcagctt tgctgtttgg gcatgataaa ggtgaccgtt 1487341 atgaaaggga ttatattcaa ccaccaatcc gacagctttc atattttttc cgcctttctt 1487401 gctatgttta aaaacgtatg gtacatttgc aaatgaaaac tcttacgcct tatttttgtt 1487461 ttaagtgtat gcatagcata ttccgctgtc aacgatactt caatggcagc attatgctgt 1487521 aaagaaaaaa tattgacaaa aacaatctta aaagctataa tcatgtttgt tgctttcctg 1487581 aggtgataca aatgaaatgg acgatttatc agctgcatca aatgccaaaa caaagttttg 1487641 agtttgatga aacagttgag ttaaatgagc tgacaaagct gaattctgac attcgccgca 1487701 tttctcccgt tcgggtgaag ggcagagcgg atatcaaatc caaacaggtt tcgtttgatt 1487761 ttacaatttc aggcgaaatg cttttgccat gctcaagaac actcgttgat gttccgtatc 1487821 catttgaaat ttcaacaaaa gaactgttta tatttcatca cacggatgat atagaagatg 1487881 atgacgttca cattgttgag gacgatacta tcgacataac tccgatcgtg aaagaagaaa 1487941 ttcttttaga aatccctatg caaatctttt gtgaatctga acaagaaaaa ggagctgctc 1488001 ctcaagaagg aaaggattgg caagtcattt cggaagaaga caagaagaat caagttgatc 1488061 cgagacttgc agcccttgaa aagctcttaa aacaagatga tgaatcttaa ctctttaagg 1488121 aggtgggaat aatggctgta ccttttagaa gaacttctaa aatgaagaaa agattgcgcc 1488181 gtacacattt caaacttaat gtacctggta tgacagaatg tccgtcatgc ggagagatga 1488241 agttgtctca ccgtgtatgc aaagcatgcg gatcatacaa cggcaaagac ataaatgtaa 1488301 aaagtaacta atgagaaaag cgcagggtga aagccctgcg ctttttcttt ttctcttcct 1488361 gtcagcttgc ggaaaatttg tgagtgcaaa tagtctatct aatctattac cggcatatgt 1488421 atgagataaa taagctgaca tggagggaga ttgaatttga ccattacaag acaagatgct 1488481 tggactcagg atgaggattt gctgctggca gaagtggtgc ttcgtcatat tcgagaggga 1488541 ggaacacagc tttcagcctt tgaggaggtt ggaagggcgc tgaccagaac cgcggcagcc 1488601 tgtggtttca ggtggaactc gtatgtgaga aaacaatacc agtcaggtat agagcttgca 1488661 aaaaagcaaa ggaaagaact gagaaagcaa atcggcgttc attcggtcaa tatgccgaat 1488721 tccatgaagc agactgcctc ggcatcgtca gaaggaaaac gagatttgtc cattcaggat 1488781 gtcattcaat ttctcgaaca attcaaagaa acaccgtctg cacaagaatt tcagcttgaa 1488841 agggaaaaat tgaaggagca aatccaatcg ctgcaaaaag agcttgagga tttgcggagt 1488901 gaaaatcaga cattgcggaa tcagctagag atgacagaag aggattacaa ggcactgatc 1488961 gatatcatgg atcgggccag aaaaatggtt gtttcgaagg aagacggaag aatgaaaaaa 1489021 gcggctcaag aaacgtaaag aaacgcctga aatgaaccgg ccctatagta agaataggcc 1489081 ggttgttttg atttctatgc agactctccc ggtgtcattt cgcgatccat atcaggatgc 1489141 cagatgagcg ggttttcccc tttgtcccgc gccatatcat acttaacagt tttaaagttc 1489201 attttgttcc aaaattccgc tgatttcatt ctcggatttg tccggatcgg cattttgaat 1489261 gattttgcaa attcaaccaa ggctctcccg tatcccctgt tctggtagcc cggaagaacc 1489321 tcaagcttcc acagctccaa ataatcctgg cggttgtcaa aatagggatt cgatttgccg 1489381 ttaacttgat acagactcat tcgtgctaca agtttatcgc caaaataaat cccgtaaaaa 1489441 ggcgaggtgc tgtcattttc aataatatta tcctgaagtt cttcaagcat tgaaagctcc 1489501 tgaatgccgt attctttgaa tttcttgaat tcttccagcg ttttatagtt gataagcaga 1489561 cgttctacct ttgtcaaaca aatctccccc tttgttgttt ctacatatat tgtaaacgct 1489621 ttatttaaaa aatccaaata tttaaacttt aattttaagc acatgggatc tttgagaagt 1489681 aatttcttct tacttctgct atgataatac gtaaatgcta aattgggtgt gacatcatga 1489741 aaattggaat tatcggcgga ggctccgttg gtcttttatg cgcctattat ttgtcacttt 1489801 atcacgacgt gactgttgtg acgaggcggc aagaacaggc tgcggccatt cagtctgaag 1489861 gaatccggct ttataaaggc ggggaggaat tcagggctga ttgcagtgcg gacacgagta 1489921 tcaattcgga ctttgacctg cttgtcgtga cagtgaagca gcatcagctt caatctgttt 1489981 tttcgtcgct tgaacgaatc gggaagacga atatattatt tttgcaaaac ggcatggggc 1490041 atatccacga cctaaaagac tggcacgttg gccattccat ttatgttgga atcgttgagc 1490101 acggagctgt aagaaaatcg gatacagctg ttgatcatac aggcctaggt gcgataaaat 1490161 ggagcgcgtt cgacgatgct gaaccagacc ggctgaacat cttgtttcag cataaccatt 1490221 cggattttcc gatttattat gagacggatt ggtaccgtct gctgacgggc aagctgattg 1490281 taaatgcgtg tattaatcct ttaactgcgt tattgcaagt gaaaaatgga gaactgctga 1490341 caacgccagc ttatctggct tttatgaagc tggtatttca ggaggcatgc cgcattttaa 1490401 aacttgaaaa tgaagaaaag gcttgggagc gggttcaggc cgtttgtggg caaacgaaag 1490461 agaatcgttc atcaatgctg gttgacgtca ttggaggccg gcagacggaa gctgacgcca 1490521 ttatcggata cttattgaag gaagcaagtc ttcaaggtct tgatgccgtc cacctagagt 1490581 ttttatatgg cagcatcaaa gcattggagc gaaatacaaa caaagtcttt tgagcttttt 1490641 cggtaacatg ctatactcat ttcggatcac taactattta ttggagaaag gaagttctag 1490701 aagatgcagc taactgaact ttccatcaaa aatcagaatg tgtttgtaca gcactatata 1490761 gatggcaaag aagaaatgtc ttcttttttt gattacagta ttcatcataa ggacatgtgg 1490821 cgcgaaagac tggaagactt atcttcccgg tttttcgcaa gagaggaatt ggcggcgtac 1490881 ttaacctctt accataataa attcggttca agtgcgatgc agtctgctat tgagaagctg 1490941 aaggacccgt caagtgccgc tgtagtcggc ggacagcagg caggactttt aacaggaccg 1491001 ctttacacca tacataaaat catttcaatc attgttttag caaagcaaca agaaaaggaa 1491061 ctgcaagtgc ctgtcatacc aatcttctgg gtggctggag aagaccacga tttggatgag 1491121 attaattttg ttcacacatc tgaagagaat gggcctgtga aaaaaaagct gcctcagtct 1491181 tattggaaga aatcatcagc agcgagtaca tcgcttgatc aggaaaagtg tgccgcgtgg 1491241 atagatgatg tttttgccgc ttttgaagaa acagaccata cgaatacact tctcgacaat 1491301 gtgaaacgat gtttaaggga atctgttacg tttactgact tctttgaact gctgatcgcg 1491361 gatttgttcc aagaagaggg cttagtttta ttaaattctg gggatccggg gattaaaaag 1491421 ctggaaacgg ccatgttcca aaagattctt cgagaaaatg atgaactcgc ccgggctgta 1491481 tcagatcagc aggccttcat gcgtcaagca ggctacaaac cgattatcga gtccggaaaa 1491541 gagcaggcga atctgtttta tgaatacgaa gatgagcgtt ttttaattga aaaagataac 1491601 ggccgatttg tcatcaaaga gcttgatcta ggatggacga gggatgaact tcatacacat 1491661 atggaagaac atccagagcg tttcagcaac aatgttgtaa cgagaccgtt aatgcaggaa 1491721 tttctcattc cgactttagc atttattgca gggcctgggg aaatcaatta ttggggcgag 1491781 ctcaaacagg catttgcggt gatgggcttc aaaatgcctc ctgtcatgcc aaggctgaac 1491841 attacgatac ttgagcggca tattgagaaa aaactggctg aacggaatat ctcattacaa 1491901 gacgcgattg agcgcggaac ggagaatcaa agagagacat acttcgagcg ccagattccg 1491961 gaagagttta cggcggtgat ggatcaggcg aaaagccaaa ttgaagcgat tcacaaaacg 1492021 gtccggcagg aggcgttaaa ggttgatcaa agcttggaac ctttacttct gaaaaatgcc 1492081 gcttttattc aggatcagct tcaattctta gagcgcacgg tgatgaagcg aattgaagaa 1492141 aaagaaggct acgtcttgaa ggattatgaa agaattcaaa atagcattaa gccgcttctt 1492201 gcgccgcaag aacggatttg gaatatcatg tattatttga acaggtacgg tccaaaattc 1492261 ttcacgacat tcaagaatct gccattttct tttcaaaatc aacatcaagt tgtcaaactt 1492321 tgaaataaag ttttaaagaa ccctgactag ttcagggttt ttttttatgg gtaaacagtg 1492381 taaaatgaag ttgtggagcg aagtggtgaa tagtggtgag ttaaggagag aaagtggggc 1492441 aagagatcat gtttatgggt gaatatcagc ataccatcga tgcgaaaggc cgcatgatcg 1492501 tacccgctaa attcagagaa ggcctaggtg agcaatttgt gctgactaga ggacttgacc 1492561 aatgtctctt cggctaccct atgcacgaat ggaaacaaat tgaagaaaaa ctaaaagctc 1492621 ttcctctcac aaagaaagat gcccgcgcgt ttacccgttt cttcttttca ggggcgactg 1492681 aatgcgaact ggataagcaa ggcagggtaa atatcgcatc atctctattg aattacgcca 1492741 aactggaaaa agaatgtgtt gttatcgggg tttctaatcg aattgaattg tggagtaaag 1492801 taatttggga acaatacaca gaagagcaag aagattcatt tgctgaaatt gctgaaaaca 1492861 tgattgggtt tgatatataa tgattcttcg tgtataacac tctaaaaaca atttcaattc 1492921 atcctgataa aaggtgggac caacacaata tgtttcaaca caagacagta cttcttcgtg 1492981 aaaccgtaga cggacttaat attaaaccag acggtacata tgtagactgc acactcggcg 1493041 gagctgggca tagtacatac ttattgcagc agttatccga gaaggggcgt ttaatcgctt 1493101 ttgaccaaga tgatacggca ttacagcatg ctaaagaagt gttgtccgat tataaaggac 1493161 agctcattct gattaaaagc aatttcaggt atttaaaaga atatttgaat gaacaaggcg 1493221 ttacagaagt agacggcatt ttatttgatt taggggtgtc ctctccgcag ctggatacac 1493281 cggagcgcgg attcagttac catcatgacg caccgttgga catgaggatg gaccagtcgg 1493341 ctacgctttc ggcgaaagaa gtcgttaatg agtggcgcta tgaggatctc gtccgtattt 1493401 tctttaaata cggagaagag aagttcagta aacagatcgc cagaaaaatt gaggaggcaa 1493461 gaatgaagtc tcctattcaa actacgggcc aactggtcga tctaataaaa gacgcgattc 1493521 ccgctccagc gagaaggagc gggggacatc ccgctaaacg cgtgtttcag gcaatcagaa 1493581 ttgccgtaaa cgatgaactt agggtgtttg aagaagcttt ggagcaggca attgaggttc 1493641 tgaagccagg gggcagggta tcggtcatta ccttccactc gctagaagac agaatttgca 1493701 aaaccacttt taaagaaaag tcgtcgcttc cggaacttcc tccgggactt cctgttatac 1493761 cggaagagtt tgaaccggag ctgaagctca tcacacgaaa accgattacg gcatctcaag 1493821 aagagcttga agagaacaac cgggctcgtt ctgccaagct tcggattgct gaaaaaagaa 1493881 aataacgaaa cgcgaacgca aaattaaaag gaggtcatca gcctatgagc aatttagctt 1493941 accaaccaga gaaacagcag cggcatgcga tcagtcctga gaaaaaagtg attgtcaaga 1494001 aaagggcttc cattactctc ggagaaaaag tgcttcttgt cctctttgct gcggcggtgc 1494061 tcagcgtatc gcttttgatc gtatcgaagg cgtatgcggc atatcaaacc aatattgagg 1494121 tgcaaaagct tgaggagcaa atttcatccg aaaataagca aattggtgac ctcgaaaaaa 1494181 gcgttgctga tttaagcaaa ccgcagcgca ttatggacat tgcgaaaaag aacggcttga 1494241 atttaaaaga taaaaaagtg aaaaacatac aggaatgatt caaatgccaa aaaagaataa 1494301 atttatgaat agaggagcag cgattctaag tatttgtttc gctctctttt tctttgtcat 1494361 cctggggaga atggcatata ttcaaataac cggaaaagcg aacggcgaag tgcttgcgac 1494421 aaaagcgaca gagcagcatg aaaagaaacg gaccatcgaa gcgagccgcg gctcgatttt 1494481 agaccgaaaa ggaaaagtca ttgcagagga cacagcgacg tataaactga ttgcgattct 1494541 cgataaaaaa atgaccactg atgtcaagca tcctcagcat gttgtaaaca aagaaaaaac 1494601 ggcggaagca ttgtctaaag tgataaactt ggacaaggcc gacatccttg atatcttaaa 1494661 taaagatgca aaacaagtcg agtttggctc agctggccgg gatattacgt attcacaaaa 1494721 gcaaaaaatc gaaaaaatga aactcccggg catttcattt ttacgggata caaaacgcta 1494781 ctatccaaac ggagtatttg catctaatct aatcggctat gccgaggttg atgaagaaac 1494841 aaatgaaatt tccggcgcga tgggattaga aaaagtgctg gataagtatt tgaaggagcg 1494901 ggacggatat gtgacatatg aaagcgacaa atccggctgg gagctcccga acagcaaaaa 1494961 taaaattaca gcgccaaaaa atggtgacaa tgtatattta accattgacc agaaaattca 1495021 aacctttttg gaagacagca tgacaaaagt ggcgcaaaag tataatccga aaaaaatcat 1495081 ggccgcagtc gttgatccga aaacgggcaa agtccttgcc atgggacagc gcccaagctt 1495141 tgatccgaac aagcgcgatg tgacaaacta ctataatgat ttgatttcat atgcgtatga 1495201 acccgggtcc acgatgaaga tctttacact cgctgctgcg atgcaggaaa acgtgtttaa 1495261 tgcgaacgaa aaatataaat cagggacatt tgaagttggc ggagcacctg ttaaggatca 1495321 caataacggt gtaggctggg gtccgacaac atatcatgac ggcgtcctaa ggtcgtcgaa 1495381 tgtcgctttt gcgaaactgg cgaaagaaaa gctgggatat gaccgcctca atcaatattt 1495441 gcacaaattc aatttttacc agaaaacagg tattgatttg ccaggagaag tctccagcaa 1495501 aatcaacttt aaatatgaat ttgataaggc gtcaactgca tatggccaag cgtctgcggt 1495561 cacaccaatt cagcagattc aggccgcaac ggcaattgca aatgacggta aaatgatgaa 1495621 accttatgtc attgaccata tcgttgaccc tgataaagat aaaactattt atcaaaataa 1495681 gccggaatca gccggaactc caatttctgc aagtactgcg aaaaaggtgc gggatatatt 1495741 aggagaagtc gttacatcga agatcggaac agggcaagct tataaaatcg aaggttttga 1495801 tgttgccggg aaaacaggta ctgcgcaaat agccggtaaa ggcggatatt tagacggcac 1495861 agataactat atcttttcgt ttatgggtat ggcgccaaaa gatgatcctg agcttttaat 1495921 ttatgttgct gtacagcagc cgcaactaaa agcaggacaa agcagttcag atccagtatc 1495981 agaaatcttc aatccaacaa tgaaaaatag cctgcactac ctaaacatcg aaccaactga 1496041 aaaatctgac tcagataagg aagaaacaaa agcgcagaca atgcctgatt taacagatca 1496101 aacggtagct gctgctcaaa agaaagcaaa agaggagaat ctcacaccaa ttgtcatcgg 1496161 cagtgatgtc gctgtaaaag aacagtatcc gaaagcggat gaggaagttc tcaccaatca 1496221 aaaggtcttc ctgaaaacgg gcggcaaaat caaaatgcct gatatgacag gctggtcgag 1496281 aagagaggtt ctgcagtacg gcgagctcgc gggaattcat attgaagtaa gcggacaagg 1496341 ctacgctgtc agccaaagtg ttaagaaaga caaagaaatc aaagacaaaa ccgtaatcaa 1496401 ggttaagttt aaaaatcctg attaaaaaga aagccgtcgt tatgcaggct ttcttttttt 1496461 atgccttcag aggagcatcg ttctacctgt ccaaattcag gcataaaatg aaacaagcct 1496521 aaataaggag tgaacggtct cttgcgcgtc tcgaatgtaa cggttagaaa acgtttatta 1496581 tttgttttgc tttttggcgt gatcgtgttt ctgatcattg atacaaggct ggggtatgtt 1496641 cagtttgtga tgggcgaaaa actgacttcg ctagcgaaag attcctggag ccggaacttg 1496701 ccgtttgagc cggagagagg cgagattctg gatcggaatg gtgtgaagct cgcaacaaat 1496761 aaaagtgcgc cgaccgtatt cgtcgtgccg cgccaagttc agaatccgat gaaaacgagc 1496821 aagcagcttg cggcggtgct caatatgtca gaagaaaaag tatataaaca tgtgacaaaa 1496881 aaagcgtcaa tcgaaaagat cactcctgaa gggagaaaaa tttcaaatga gaaggcgaaa 1496941 gaaatcaaag cgcttgattt aaaaggtgtg tatgttgcgg aggacagtat ccgtcattac 1497001 ccgttcggca gctttttatc tcatgtgctt ggatttgcag gaattgacaa ccaagggctc 1497061 cttggacttg aagcctatta cgacgatgat ttaaaagggg aaaaaggttc tgttaagttt 1497121 tatacagatg ccaaggggaa gaagatgcct gatgaagcgg atgactatac gccgcctaag 1497181 gatgggcttg atatgaagct gacagttgat tcaaaggttc agacgataat ggaaagagag 1497241 cttgataacg ctgaggccaa atatcatccg gacggcatga ttgccgtagc catgaatccg 1497301 aaaaacggag aaattttggg gatgtctagc aggcctgact tcgaccctgc tgattaccaa 1497361 tctgttgatc cgtccgtcta caatcgaaat ctgccagtat ggagcacgta tgaaccggga 1497421 tctaccttta aaattattac acttgcagca gcccttgaag agcaaaaagt aaatttgaaa 1497481 cgggatcaat tttatgataa agggcatgct gaagtggacg gagcgagact gcggtgctgg 1497541 aaaagaggcg ggcacgggct gcagacgtat ctggaagttg tgcagaactc ctgcaacccg 1497601 gggtttgttg aattaggcga gcgcttagga aaggaaaagc ttttcaaata tatcaaagac 1497661 tttggttttg gacaaaaaac ggggattgat ctccaaggcg agggaacagg catcttattc 1497721 ccgcttgaga gagtgggccc ggtggagcaa gcaactacgg ctttcggaca gggagtatcc 1497781 gtcacgccga ttcagcaggt tgcagcagta tccgccgctg taaacggagg aacgctctat 1497841 acaccttata ttgcaaagga atggatcgat cctgttacga agaaaacggt caaaaaacaa 1497901 tcaccaatcg caaagaaaca agtcatttct gaggaaacat ccaaacaaat ccgctatgct 1497961 ctagaaagcg tcgtcgcaga aggaaccggc cgcaatgcat ttgtagaagg atatcgtgtc 1498021 ggaggaaaaa cgggaactgc acaaaaggtt aaagatggaa aatatcttga aaacaaccat 1498081 attgtatcat ttatcggttt cgcgccagca gatgatccga gtctagtcgt ctacgttgcg 1498141 gtggataacc cgaaaggcac gattcagttt ggcggaacgg tggcagcgcc tattgtcgga 1498201 aatattatga gagacagtct gccggaactt ggtgtgaagc cccggaaaaa tcaaatcgag 1498261 aaaaaatacc aatggaacga cacaaaaaca atagaagttc cgaatgttgt agggatgtct 1498321 gtctcagatc ttgagtcact attggtgaat ctcaatgtgg atgcttccgg gaaagggagc 1498381 aaaatcgtta aacaatcgcc agctgccgga acgaaagtaa aagaaggctc aaagatacgc 1498441 gtgtatttga ctgaagaaga tgaaaaggag gcagccgatt gattcgggct gcctattctt 1498501 ttattgcaga aaaaatgctg atatctttca agattagctg gatgtatcct tttatttacg 1498561 ctaaaatatg aactgtatgc ttaaaatcat taccacatca tttgatgtga cttcaatgat 1498621 aaaaagaacg aattagaatg ttgagaggtt tgatacgatg aaacttacaa agctgcttac 1498681 atacttaaca accgaacctt ctgtaaacga ctcacaagac cctgaaataa cttcaattga 1498741 gatggactcc agggaagtaa agaaagggag tctttttgta tgtgtaaaag ggtatacggt 1498801 ggatggccac gattttgcgc aaaaagcagt agaaaacggt gcagcggcta ttgtggcaga 1498861 aagagaggtc gatgtgaatg ttcctgttat tattgtccgg cagtcacttc gcgcgctcag 1498921 cgttttgtct gatgcgtttt acggacagcc gacgaagaag cttcagctga ttgggataac 1498981 agggacaaac ggcaaaacat caacgaccca catggtcgat gagattctga aaaaagcggg 1499041 aaaacgcaca ggcttgatcg gtacaatgta catgaaaatc ggagacgaaa cacttcctgt 1499101 taaaaacacg actccggaaa gcgtcacgct gcagaaaacg tttaagaaaa tgaatgacaa 1499161 gcacgttgac actgcaatca tggaggtttc ttcccacgct ttgtctttag gacgcgtcca 1499221 tggctgtgat tatgatattg ccgtgtttac gaatttaaca caggaccatc tggactatca 1499281 taaaacgatg gatgagtacc ggcatgcaaa aagcttgctc ttttcccaac ttggcggggc 1499341 tttcaaccat gaacatccaa agcgtgccgt cctgaatgct gacgatgagg cgagcgctta 1499401 ttttgaaaag gtaacagctg cgcatatctc tacatacgga attaaaaacg atgctgatgt 1499461 gatggcgaag aacatcagta tcactgcaca gggcacaagc tttgatctcg tgacaaacaa 1499521 aggcacgaag cacatcacga tgtctctcgt cggacaattt aatgtgtata acgtgctggc 1499581 cgctgttgcg acatgtattg cagcaggcat accgtttgaa atcatcactg aggctgttga 1499641 agaattgcat ggtgtaagag gccgttttga attggtcaat cagcagcagg agtttcctgt 1499701 cattgtagac tacgcgcaca caccggacag ccttgaaaat gtgctggaga catgcagaga 1499761 catgacggaa ggaaagctat ttgtcgttgt cggctgcgga ggagacagag ataagacgaa 1499821 gcgcccgaaa atggctaaaa ttgctgtgga gctggctgac gagccgattt tcacgtcaga 1499881 taacccgaga agcgaagatc ctcgcgcgat tttaagagat atggaagccg gagtagagaa 1499941 cgcatactat cacagtattg caaaccgcga gcaggcgatc tttttcgcaa ttgccaatgc 1500001 caaaaaaggc gacgttgtcc tcattgccgg aaaaggacat gaaacctatc agcagatcgg 1500061 aaatgaaact ttcgattttg atgatgctga agtagcggcg agagccattg ttgaactcaa 1500121 taagaataag acgaattcat aggaaagaga tgttactgaa taatggagct tgaaaagatt 1500181 tttcatatgg aaaaaaatca tgaatatgat aactacgtat gtcgtttgaa agaaacagga 1500241 ggagaaaagg acaatgcttg agcaagtcat tctgtttaca attttaatgg ggtttttaat 1500301 tagtgttctg ctctctccga ttcttattcc gtttttaaga agattaaaat tcggccagag 1500361 tattagagaa gaaggaccga aatcacatca gaaaaaatca gggacaccga caatgggcgg 1500421 ggtcatgatc atactttcta tcatagtgac aacaattgtt atgacacaga agttttcaga 1500481 aataagcccc gaaatggtgc tgcttctgtt tgttacgcta ggctacggtt tgcttggctt 1500541 tttagatgat tacatcaagg ttgtcatgaa gcgcaatctt ggattgacat caaagcaaaa 1500601 gctgatcgga caaattatta ttgcggttgt attttacgcc gtgtatcatt actacaattt 1500661 tgcgacggat attcgcattc ctggaactga cttatcattt gatcttggct gggcttactt 1500721 tatccttgtg ctctttatgc tagtcggcgg atcaaacgca gttaacctga ctgacggcct 1500781 tgacgggtta ttatccggta ctgcggcgat tgcctttggc gcctttgcca ttctggcatg 1500841 gaatcagtct caatatgacg tagcgatttt ctcagttgcc gttgtcggtg cagttctggg 1500901 cttccttgta tttaatgctc atccggccaa agtttttatg ggagatacgg gatcgcttgc 1500961 attgggagga gccatcgtta ccattgccat tttaacgaaa ttagagatcc tgctggttat 1501021 catcggcggt gtattcgtta tcgagacatt atccgttatt ttgcaggtca tcagctttaa 1501081 aacgacaggt aaacgaatct ttaaaatgag tccgcttcat caccattatg agcttgtcgg 1501141 ctggtctgaa tggagagtag tcgtgacgtt ttgggctgcg ggacttttgc ttgccgtttt 1501201 aggaatttac atcgaggtgt ggttataagt ggaaaatgat caatttttac agaaacagca 1501261 ttttttaatc cttgggcttg cgaaaagcgg atatgcggcg gcctccattc ttcatgaaaa 1501321 aggcatttat gttgcagtca atgatcaaaa gccttttgaa gaaaatgaac cggcacaaaa 1501381 gctttctgaa aaaggaatcg aagttgtttg cggagagcat ccagtttctc tgttcgatca 1501441 gcatcaaatc acgattctga tcaaaaaccc gggaattcct tatgaaaata tcatggttca 1501501 ggaagcagag aaacgaggta ttccggtttg gacggaaatt gagctcgctt actacctgac 1501561 cagcgccaag tttatcggga ttaccggatc gaacggtaaa acgaccacga caacgctaat 1501621 ttacgaaatg ctcaaggctg actcgcaaaa agcactgatt gccggaaaca tcggcacagt 1501681 cgcaagtgag gttgcctatc atgctgatgg agatgaatgg atcgttaccg aactgtcttc 1501741 gtttcagctg atgggaacac acgctttcag accggaaatc agcctgattt taaatgtatt 1501801 tgacgcccat ctggattatc accatacgcg cgaaaactat gaaaaagcga aacagaaagt 1501861 gtaccttcat cagactgctt cagataaagc tattgtcaac caggatgatg aaaccgtcgt 1501921 gcgtcttgct gaagccggaa aagccgaaat cgtcccattt tcagtcagca aaacgcttga 1501981 acagggcgca tatgtaaaag acagtatgat tatgtttaac ggcgaagcca ttcttcctct 1502041 ggaagaggtt gtactgcccg gtgctcataa cctggagaac attttagcag ctattgcagt 1502101 tgtgaaaacg gcaggagcat ccaatgaggc ggttaaaaag gtgctgacaa gctttactgg 1502161 tgtgaagcac cgcctccaat atgtcacaac tgtgaatggc cgcaaatttt ataacgacag 1502221 taaagcaaca aacattctgg cgacaagcaa ggcgctttca gcttttgata agccggtcat 1502281 tctgcttgcg ggcggactgg atcgcggaaa tggttttgat gacttgaaac cttatatgaa 1502341 gcatgtcaaa gcagtgctta catttggcca gacggcgcca aaactcgaga aactcggcaa 1502401 tgaactggga atacaacatg tcaaacgtgt cgataatgtt gaacaagcag tatctgcggc 1502461 gtttgcgctc tcaaatgaag gagatgtcat cctgctgtca cccgcgtgtg cgagctggga 1502521 tcaattcaaa acatttgaag aacgcggtga catgtttata gatgccgtgc atatgcttaa 1502581 gtaagggctt gtcttgaagt aaatcggcag ccctaatgac tttaagcttg gggtgtcgat 1502641 tgctttgact actaaaaaaa catcgcctga tttgttattg gtcatcatta cgttattatt 1502701 attaacaatc ggattaatta tggtgtacag tgcgagtgcg gtatgggcgg attataaatt 1502761 tgacgactca ttctttttcg cgaaacggca gcttttgttt gcgggaatcg gcgtcattgc 1502821 tatgtttttt atcatgaatg ttgattattg gacttggagg acatggtcca aattgctgat 1502881 ggttatctgc tttttccttc tggtgcttgt tttgataccg ggcgtcggaa tggtgcggaa 1502941 cggttcaaga agctggatcg gagtcggagc attcagcata cagccttcag agtttatgaa 1503001 gcttgcgatg attgcattcc ttgctaaatt tctctctgaa aaacaaaaaa acatcacatc 1503061 gttcagacgg gggttcgtcc ctgcacttgg catcgtgttt tcagcatttt tgattatcat 1503121 gtgccagcct gacctcggaa cggggacagt tatggtcgga acttgtattg tcatgatttt 1503181 tgtagccggc gcacggatcg cccatttcgt ctttctcggg ctgatcggcc tcagcggatt 1503241 tgtcgggctc gtactatcgg ctccatatcg gataaagcgg attacctcat acttaaatcc 1503301 atgggaagac ccgctcggaa gcggatttca gatcattcaa tcgctttatg cagtggggcc 1503361 cggcgggttg ttcggaatgg ggctcggaca aagcagacag aagttctttt atctgcctga 1503421 gccgcaaaca gactttattt tcgccatctt gtcagaggag ctgggcttta tcgggggaac 1503481 acttattttg ctcctcttca gcgtcctgct gtggagagga atcagaattg cgcttggtgc 1503541 gcctgatctg tacggaagct ttgtcgcagt cggcattatt tcaatgattg ccattcaagt 1503601 catgataaat atcggcgtag tcacgggcct gattcctgta acaggcatca cgctcccgtt 1503661 tctgagctac ggaggctctt cattgactct aatgctgatg gcagttggtg tgctgctgaa 1503721 tgtaagccgc tactcgaggt attaacgaat gtatttccaa gcctcctgtc taacatgaag 1503781 cttggaaaca attgatgcga taaccctgtc caacaaaaca gggttatcgt tatgttatag 1503841 agaaacttag actgggggaa aaaagaaatg cgaattgcaa taagcggagg cggtacaggg 1503901 ggacatattt atcctgctct tgcttttatt aaagaagtgc aaagacgtca tcctaatgtg 1503961 gaatttttat atatcggaac agaaaacggg ctggagaaaa aaattgttga gcgggagaat 1504021 ataccgtttc gttcaattga aattacagga tttaaaagaa aattgtcatt tgaaaatgtc 1504081 aagactgtga tgcgttttct gaagggcgtc aaaaagagta aatcgtattt agcggaattt 1504141 aagcccgatg ccgtaattgg aacgggcggt tatgtatgtg ggccggttgt ctatgccgct 1504201 gcgaaaatgg gaattccgac tattgtccac gaacaaaaca gcctgccggg catcacgaat 1504261 aagtttcttt caaaatatgt taataaagta gcgatttgtt ttgaagaagc gaaatcacat 1504321 tttcctagcg agaaagttgt atttacggga aacccgagag cctctgaagt cgtctcaata 1504381 aagacgggac gatcattggc tgaatttggg ctttctgaag acaaaaaaac ggtcttaatt 1504441 ttcggcggaa gccgaggcgc tgcaccgatt aaccgcgctg tcattgacat gcaggatgtg 1504501 ctgaaaacaa gagactatca agtgctgtat atcaccggtg aagttcacta tgaaaaagta 1504561 atgaatgagc tgaaaagcaa gggtgccgct gataatatgg tcacaaagcc gtttcttcat 1504621 caaatgcctg agtatttaaa ggccattgat gtcattgtgg ccagagccgg tgcgacaacg 1504681 attgccgaaa ttactgctct cggaatccca agtgttctga tcccaagtcc atatgtgaca 1504741 gcgaatcacc aggaggtcaa tgcgaggtct cttggccagc atgatgcggc gattgtactg 1504801 aaagaaacag agctcagcgg ggagaagctg attgaagcgc tagaccggat tgtactgaat 1504861 gagcaaacgt taaaggaaat gagcgaacga acaaagtcac tcggtgttcc tgacgcggct 1504921 gcccgtttat acagcgtact cgaggaatta aaaaaatagt agaaaagcaa atggaatgcg 1504981 gaggtttacg atggagaaag tgatacagga attaaaagaa cgagaagtcg gcaaggttct 1505041 tgcaaatgaa ccgctcgcga atcatacaac gatgaaaatc ggcggacctg cggatgtatt 1505101 ggtcattcca agcagtgtgg atgctgttaa agacatcatg gacgtgatta aaaaatatga 1505161 tgtgaagtgg acagtcatcg gccgcggatc aaatcttctt gttttagatg aaggaattag 1505221 aggcgtagtg atcaagctgg gggcgggtct tgaccatttg gagcttgaag gggaacaagt 1505281 aacagtcgga ggcggttatt cggtggtccg ccttgctaca tcattgagca aaaaaggcct 1505341 gtccggtttg gaatttgctg ccggcattcc aggatcagtc ggcggagcgg tttatatgaa 1505401 tgccggcgct cacggttctg atatgagcga gatcctcgtc aaagcgcata ttttatttga 1505461 agacggaacg attgagtggc tgacaaatga gcagatggat ttcagctaca ggacatctgt 1505521 actgcaaaag aaacgcccgg gcgtttgcct tgaagctgtt ttgcagcttg agcagaagga 1505581 taaggaatca atcgttcagc aaatgcaaag caataaagac tatagaaaaa atacacagcc 1505641 gtattcaagc ccttgtgcgg gaagcatatt cagaaatccg cttccgaatc atgccgggaa 1505701 ccttgtagaa aaagcaggct tgaaaggata tcaaatcggc ggtgcaaaga tatcggagat 1505761 gcacggaaac ttcatcgtca atgcgggggg agcatcagca aaagatgtgc ttgatctcat 1505821 tgaccatgtg aaaaagacaa tccgtgaaaa atacgagatt gatatgcaca cagaggttga 1505881 aatcatcggc ggaaatcgct gattcaagtt ctgactgaag ctgttcatat gatatactgt 1505941 aagcaaacga caaacggcat catagtatgc cgtttgtttt ggaatagaca gacttttaac 1506001 agctgtttca tttgaatgag gtgaacaggc aatgaacccg ggtcaagacc gagaaaaaat 1506061 cgttaacatt gaagagcgga tccctaaaat taaagagcag aggaaacaaa aggcaaaccg 1506121 ccgtctcatt tcatttatta tgctcttttt tattatggtg ctgatcattg tgtacctgca 1506181 aacaccaatc agtaaagtat caacaatctc tgttacaggg aatgaaaatg tatcaaaaaa 1506241 ggaaattatc gacctttccg atattaacag cggagatact gagttttgga gtttggacaa 1506301 gcaaaaaaca gaaaagaaga ttcagcaaaa taaattagtg aaaaaagcgg agatcagcaa 1506361 atcgcttcct aataaaatca acattgcaat cgaagaatat aaagcgattg cttatttaga 1506421 aaaagacgat gtgtactatg aagtgcttga aaacggctca gttctgccaa acgaagtaac 1506481 gccggatgat gccggaccga ttttagtgaa ttggacaaac gcgaagaagc ggtctcaaat 1506541 ggccaagcag ctcgatgcgt tgtcaaattc gttaaaacag tcgatttcag aaatttatta 1506601 tacgcctgta aaaatggatg aaaaccgtat taagttgtac atgaacgacg gttatgttgt 1506661 tacggcatct attaaaacgt ttgcagaccg aatgaagacg tatccttcta tcatctcaca 1506721 gctaagcagc aataaaaaag gaatcattca tttagaagtt gccacctatt ttgaagagtt 1506781 tgggaaaaac gataaagctg ctaaaaagga agatgaaaat tgaggggcaa atcagcagtc 1506841 cttctttcct tgattatgct tatcgcaggt tttttgattt cattttcttt tcaaatgaca 1506901 aaagaaaaca acaaaagcgc ggctgagacg gaagagtgga aaaaagaata tgcgctgaga 1506961 gatgaactgc tgaaacaaga gaaagaaaat aagaagtttg aaaaagaatt atatcaaaag 1507021 caaaacaaag tccgccaggc ggaaaataag ctgaagaaag agaagtcgga atactataat 1507081 gtcctcgaag atacagaaaa atacaggatg tatattgggg aagtcggtgt gcagggagaa 1507141 ggcgttgagg tgacattgga agatgcgtca tacataccgg aaggggagaa tgtgaatagt 1507201 tacatcgttc acgaaagcca tatcttccaa gtagtaaacg aactgtatat ctcaggagcg 1507261 gcagctgtcg ccgttaatgg acagcgtttg acgcatgatt cgtatatcaa atgcaatggt 1507321 cctgtggtaa cggtagacgg ggtgcagcat cccgctccgt ttacggtatc cgctattgga 1507381 gatccagatg tcctgctgcc ctcgttaaat atcgctggag gcctaattga tcagctgtca 1507441 atggatcata tttctgtgtc ggcagaaaaa gagaaaaacg tacaaatgaa accgattctg 1507501 aaaacgaagg aatgactgaa aaagcgggtg aaatagattg aaaataaagc gttccttcat 1507561 aagcatcagt gttcttatgg tcatcttcgg cctgatgata tctgttcagt ttaattcgtt 1507621 aaagcacccc aaagtccggg atacaagaga tatgtgggat attagggaag agctgacatc 1507681 agagcagaag aagcaggaaa agctgctggc tgaaataaac aaatatgaca aattgctgaa 1507741 tagctattcg caaacgaaag aaatgacaaa agaaaccgcg ctaaataata ccttgcaatc 1507801 cttaaaaaaa acagccggca tgaccgatat aacaggtagc ggaattgtca ttacgatttc 1507861 cccgcttttt tctgaaagct taacaggaga gccgatcgaa aatccgcctc cggatttgct 1507921 gaaaaagctg ataaatgaac tcaactccta cggtgcagag catatctcga ttaatgagcg 1507981 aagagttgtg aatcatacag tcatcagaga tataaacggc actacaaaaa tagacggata 1508041 cgcccttgac gattatcctt taacagtaaa agtgcttgcc aaagatccgg acatgttaca 1508101 cagcagagtg aaggggtcag gccttgagga tctttttgca tctgaaaatt tagcattaaa 1508161 agccggtaaa tctgaaagca aactaacatt aaaagcatat gacagaccac tggacgtaca 1508221 acagctgaaa ctgcttaaag actgaaaagg aggagaattg tcatgtggct gcccgtgttg 1508281 ggactggtgc tcggaatagc gattggacta atgacaaact taacgatacc gagtgaatac 1508341 tcaaactatt tatcgcttgc ggtgcttgcc gcacttgata cattaatcgg cggaatcagg 1508401 gcgcatttac aaggtacata tgatgaaatg gtatttgttt ccggtttctt ttttaatatt 1508461 atattggcaa taagtttagc ttttctggga gtccatcttg gtgtagactt gtatttagca 1508521 ggtatattcg catttggagt cagattattt cagaatatag ccgttatcag aagaaatcta 1508581 ctaacaaagt ggactctttc taaaaaaaat aaaaaaaatg tgatataaaa gaggatatac 1508641 ataggatata acgaatattt tcaataaaca taaaatgtga aaagcacata aaaatattct 1508701 gttgttattt tttgttacac acttgtaaag ccacattcat tgtattgttg ttccgcaaat 1508761 aatagaatag aaatgatcga aatgtgagga ggtgccatag aatgaacaac aatgaacttt 1508821 acgtcagtct tgacatcggt acgtccaata caaaagtgat cgtcggagaa atgacagatg 1508881 attcccttaa tattatcggt gtgggaaatg taccgtctga agggttgaaa aaaggctcaa 1508941 tcgttgatat agatgagacc gttcattcta taagaaaagc gtttgaccaa gctgaaagaa 1509001 tggtaggttt tccgcttaga aaagctattg tcggcgttaa tggaaattat atcaatattc 1509061 aagatacaaa cggtgttgta gcagtttcca gtgaaaataa agaaattcag gttgaagatg 1509121 tacgccgtgt catggaggcg gcacaggttg tttccgtacc gcatgaacag ctgattgttg 1509181 acgtcattcc taaacagttt atcgtagatg gaagagatga aatcaccgac ccgaaaaaaa 1509241 tgctgggtgt gcgtttagaa gtagagggca ccttgatcac cggttcaaaa acaatcttac 1509301 ataacttact ccgctgcgtt gaaagagctg gtattgaaat aactgatatt tgccttcagc 1509361 cgctggcagc cggttctgct gcattatcaa aggacgagaa aaaccttggt gtggctctca 1509421 ttgatatagg gggagggtca acaaccattg ccgtattcca gaacggacat ctcacttcta 1509481 cccgtgtcat tcctctcgga ggcgaaaata tcaccaaaga tatctccatc ggattgagaa 1509541 cgtcaacaga agaagcagaa cgcgtgaaaa agcaacttgg acatgcctac tatgacgaag 1509601 cctcggaaga tgaaatattt gaggtaaccg ttataggcac caatcaaaaa caaacattta 1509661 cacagcaaga agcagcgaat atcattgaag cgagagtaga ggaaattctt gaaattgttt 1509721 cagaagagct tcgcagtatg ggaattaccg atctgccggg aggcttcgtg ctgacaggag 1509781 gacaagcagc tatgccgggt gtcatgtctt tggcacagga tgtgctgcaa aacaatgtca 1509841 gagtggcaag cccgaattat atcggtgtaa gagatcctca atatatgacg ggagtgggcc 1509901 tgatccaatt cgcctgccgg aatgcaagaa tccaaggcag aaaaataggc tttaagatgc 1509961 ctgaagaagc gatacaggaa atcgcagtct catcatctga ggaacaagag cagcatcatc 1510021 accaaaatga ggtgcagcag cggccaaaag gaaaacaaaa aacacaagcc gaacataata 1510081 aacagagcaa aatgaaaaaa ctattaagca tgttttggga atagatagat agtcattcgg 1510141 cagattagga ggatttagca tgttggagtt cgaaacaaac atagacggct tagcatcaat 1510201 taaagtaatc ggagtaggag gcggcggtaa caacgccgtt aaccgaatga ttgaaaatga 1510261 agtgcaagga gtagagtata tcgcggtaaa cacggacgct caagctctta acctgtcaaa 1510321 agcagaagtg aaaatgcaaa tcggcgcaaa gctgactaga ggattgggag caggtgcgaa 1510381 tccggaagtc gggaaaaaag ccgctgaaga aagcaaagag cagattgaag aagcacttaa 1510441 aggtgctgac atggtattcg tgacagctgg tatgggcggc ggaacaggaa caggtgccgc 1510501 accggttatc gcacaaatcg cgaaagactt aggcgcatta acagtcggcg ttgtgacaag 1510561 accgtttacc ttcgaaggac gcaaaagaca gcttcaggct gcaggcggaa tctcggcaat 1510621 gaaagaagcg gtggatacac tgatcgtgat cccgaacgac cgtatccttg aaattgttga 1510681 taaaaacaca ccgatgcttg aagcattccg cgaagcggat aacgtacttc gccaaggggt 1510741 tcaaggtatt tctgacttga ttgctacacc tggtcttatc aaccttgact ttgctgatgt 1510801 gaaaacaatc atgtcaaaca aaggatctgc tttgatgggt atcggtattg ctactgggga 1510861 aaatcgcgcg gcagaggcag caaaaaaagc aatttccagc ccgcttcttg aagcggccat 1510921 tgacggtgcg caaggcgtcc tcatgaacat cactggagga acaaacctca gcctatatga 1510981 ggttcaggaa gcagcagaca ttgtcgcttc ggcgtctgat caagacgtaa acatgatttt 1511041 cggttctgtt attaatgaaa atctaaaaga tgagattgtg gtgacagtga ttgcaaccgg 1511101 ctttatcgaa caagagaagg acgtgacgaa gcctcagcgt ccaagcttaa atcaaagcat 1511161 caaaacacac aatcaaagtg ttccgaagcg tgagccaaaa cgtgaggaac ctcagcagca 1511221 gaacacagta agccgtcata cttcacagcc ggctgatgat acgcttgaca tcccgacatt 1511281 cttaagaaac cgtaataaac gcggctaatg taaaggacaa aatcgttttc gattttgtcc 1511341 ttttttgttt ttctcttcac actttccttc ttataaagtc tttttcccta ttgcttcctt 1511401 cgcttagtaa caaaacagat aattagaccc atttattttt gtgacatttt tatcattttc 1511461 atatatatgg aaattgaatg acatgaaacg acaatatctg taattcagat tgtctacagt 1511521 taatatacag cgatgttctg acaaaccatt cattattaaa aggagggacg acactttttt 1511581 taaaaagcat gttgaaaaag ggggatgaaa atgaggaaaa aaacgaaaaa cagactcatc 1511641 agctctgttt taagtacagt tgtcatcagt tcactgctgt ttccgggagc agccggggca 1511701 agcagtaaag tcacctcacc ttctgttaaa aaggagcttc aatctgcgga atccattcaa 1511761 aacaagattt cgagttcatt aaagaaaagc tttaaaaaga aagaaaaaac gacttttctg 1511821 attaaattta aagatctggc taacccagaa aaagcggcaa aagcggctgt taaaaaagcg 1511881 aaatcgaaga agctgtctgc cgctaagacg gaatatcaaa agcgttctgc tgttgtgtca 1511941 tctttaaaag tcacagccga tgaatcccag caagatgtcc taaaatactt gaacacccag 1512001 aaagataaag gaaatgcaga ccaaattcat tcttattatg tggtgaacgg gattgctgtt 1512061 catgcctcaa aagaggttat ggaaaaagtg gtgcagtttc ccgaagtgga aaaggtgctt 1512121 cctaatgaga aacggcagct ttttaagtca tcctccccat ttaatatgaa aaaagcacag 1512181 aaagctatta aagcaactga cggtgtggaa tggaatgtag accaaatcga tgccccaaaa 1512241 gcttgggcac ttggatatga tggaactggc acggttgttg cgtccattga taccggggtg 1512301 gaatggaatc atccggcatt aaaagagaaa tatcgcggat ataatccgga aaatcctaat 1512361 gagcctgaaa atgaaatgaa ctggtatgat gccgtagcag gcgaggcaag cccttatgat 1512421 gatttggctc atggaaccca cgtgacaggc acgatggtgg gctctgaacc tgatggaaca 1512481 aatcaaatcg gtgtagcacc tggcgcaaaa tggattgctg ttaaagcgtt ctctgaagat 1512541 ggcggcactg atgctgacat tttggaagct ggtgaatggg ttttagcacc aaaggacgcg 1512601 gaaggaaatc cccacccgga aatggctcct gatgttgtca ataactcatg gggagggggc 1512661 tctggacttg atgaatggta cagagacatg gtcaatgcct ggcgtgcggc cgatattttc 1512721 cctgagtttt cagcggggaa tacggatctc tttattcccg gcgggcctgg ttctatcgca 1512781 aatccggcaa actatccaga atcgtttgca actggagcga ctgatatcaa taaaaagctc 1512841 gctgactttt ctcttcaagg gccatctcca tatgatgaaa taaagccgga aatatctgca 1512901 ccgggcgtta atattcgttc atccgttccc ggtcagacat atgaggatgg ttgggacggc 1512961 acatcaatgg cagggccgca tgtatccgct gttgctgcac tgctgaaaca ggcgaatgcc 1513021 tcactttctg ttgatgagat ggaggatata ttaaccagca cggctgaacc gctcacggat 1513081 tcaacatttc ctgattcacc gaataacgga tatggccatg gtctggtgaa tgcttttgat 1513141 gctgtatccg ctgttacaga tggattaggg aaagcggaag gacaagtttc tgtagagggg 1513201 gatgaccaag agcctcctgt ctatcagcat gagaaagtaa ctgaagctta tgaaggtggc 1513261 agcctaccac tgactttgac agctgaagac aatgtgagtg tgacatctgt aaagctgtcc 1513321 tacaagcttg atcaaggtga atggacagaa ataacggcta aacgaatcag cggtgatcat 1513381 ctaaaaggaa cgtatcaggc agagatccca gatataaaag gaactaaact aagctataag 1513441 tggatgattc acgattttgg cggtcatgtc gtttcgtctg acgtatacga tgtaacagtg 1513501 aaaccaagca tcacggcggg atataagcag gactttgaaa ctgcacccgg cggctgggtt 1513561 gcgagcggaa caaataataa ctgggaatgg ggagttccgt caactggccc aaatacagca 1513621 gcatccggag aaaaagtata tggaacgaat ttgacaggaa attatgccaa ctcagcaaac 1513681 atgaaccttg ttatgcctcc tattaaagca cctgattcag gaagtctgtt ccttcaattt 1513741 aaaagctggc acaatttaga ggatgatttt gattacggct acgtttttgt tcttccggaa 1513801 ggtgaaaaga attgggagca ggctggtgtc tataacggaa agacatcaag ctggacggac 1513861 gaagaaattg atttatcggc ttataaaggc caaaacattc aagtgatgtt taaccttcaa 1513921 tctgatgaaa gcattgcaaa agagggctgg tatattgatg atgtagtgct ttctgacaaa 1513981 tcagccggaa aaacagtcaa aaagaataag ctgggcgtcg aaaagccgtc tggaaagcaa 1514041 aagaaaaagc cagtaaatcc gaaaaaggct aagccatctg caaacacagc ggtaaaacat 1514101 cagaacaagg ctatacagcc tcaagttttg ccgctcaagg cacaagtcag tgtagtggaa 1514161 acaggaaaat caacatattc agatcaatcc acagggcagt acacgctgaa gcacaaagcg 1514221 ggagactata cgcttatggc agaagcatat ggttatcagt cgaaaacaca aaaagtatct 1514281 ttaaagacgg atcagacgac acaagctaat tttacgttag aagagatgaa gaagggcaca 1514341 ttaaaaggca cggtcatcaa taaaacgaca ggagagccgg taacaggcgc ttccgtttat 1514401 gttgtagagg atgctgcggt ggaaccggct atgacaaacg acaaaggtga atatatgctg 1514461 gaggcctatg aaggcgctta tacgattaaa gtcgctgcac cgggttatta cagtgatgaa 1514521 ttttccgttg agttaaaagg tgatgttaca aaagaaactg cattgaagcc tttcgtcggt 1514581 tatccgggtg aaattgcata tgatgacgga acagcggaga atgccaattc ctattttgct 1514641 gccggtaacg gatgggcggt aaaaatgacg ctcgctgacg gcaaggacaa aggcatgctt 1514701 acaggagggc tgttcagatt ctgggataca gagttccctg atccgggcgg cacagagttt 1514761 aaggttgagg tatacgatgc cacaggaaaa gacggagcac cgggcaagaa aattgcaggg 1514821 ccatttaacg cggaagctct tcgcaatggc gagtggacta aggtagatct cagttcaaaa 1514881 gggattatgg tcgataaaga tttttatctc gtatatatcc agtcgaaacc tgatccgtat 1514941 tcacctggat tggcaatgga tgaaaccggc cagaattccg gccgcaactg gcagtatata 1515001 gatggaaagt ggcagccagg tgacaaagcg gatggcaact atatgattcg cgcattagtt 1515061 gattatgaag ctgctgtacc tgagattact tcaccgacag acaaatcata cacaaataag 1515121 gatagcgtca ctgtaaaagg aaacgcttct cctggcacaa cggtacacat ttataatgga 1515181 gagaaagaag caggagaaac gaaagctgct gcggatggca cgttccatgc aggcatcata 1515241 ctcaacaagg gtgaaaatga gctgacggca actgcatcaa ctgacaacgg aacaacagat 1515301 gcctccagcc caatcacggt cacgcttgat caagaaaagc ctgaattaac actggacaat 1515361 ccaaaggatg gcgggaaaac aaataaagaa acgctgactg tcaaaggggc tgtatccgat 1515421 gacaatctga aagacgtcaa ggtgaatggc aaaaaagcaa cagtagctga tggttcatac 1515481 tcagcccgta ttcttttgga aaatggaaga aatgaaatca aggtaattgc tacagacttg 1515541 gcaggcaaca aaacgacgaa aaagacagtc attgatgtga actttgacaa gcctgtcatt 1515601 tccggcttaa ttccgggaga ggataaaaac ttaaaagccg gtgaatctgt gaaaatcgct 1515661 ttctcaagcg ctgaggattt agatgcaacg tttaccattc gtatgccgct gaccaatgca 1515721 agagcgagtg tgcaaaatgc caccgaactc ccgttaagag aaatctctcc ggggagatat 1515781 gaaggctatt ggactgccac ttcttctatt aaagcaaaag gagcaaaagt agaagtgatc 1515841 gtccgagatg attatggaaa tgaaacaaga aaaactgcga atggaaaact taatatgaac 1515901 acagaaaatt aagtggaaaa aaagctgccg tcattggcag ctttttttat atcctctcat 1515961 tatacttcct cgacaaatta agcagatttc cctgaaaaat tgtattttcc tctcaacatt 1516021 aattgacaga ctttcccaca gagcttgctt tatacttatg aagcaagaag gggaacagcg 1516081 tgaggcaaga aagaaaggag tcagatgtga aaatctattt agatgtcatt tggctgttaa 1516141 acttttgttt tgatgcactt ttgcttttgc tcacggcatt tattttaaaa cggcatgtaa 1516201 aaaaaagaag actggtaggc ggagcgttca tcggttccag tattgtcctt ttgatgttta 1516261 ctcctttttc gccgattgtt gaacatccgg ctgggaagct agctttttca gttgtgattg 1516321 tggtggtgac atttggcttt aaaagatttc ggtttttctt tcaaaatttg ttttcctttt 1516381 attttgccac ttttttaatg gggggaggaa ttatcggagc ccattctttg ctgcagtcaa 1516441 attctattgt tcaaaacggt gtcatgatta ccaatcaaac agggtttgga gacccgatca 1516501 gctggttgtt tattgttggt ggctttccag cattatggtt tttttctaaa agaagaattg 1516561 aagatattga aacaaaaaac attcaatatg aggaacgagt cagcgtgcag gcagatttgg 1516621 gcagccaaac acttcatgtc agaggcctga ttgattccgg taaccagctg tacgatcctc 1516681 ttacaaaaac accggtaatg atcatttaca ttgataaact ggagccgatt ttcggaacag 1516741 ccgaaacgat gatcattcga aacacagacc cattggaagc catcgaacag ctcgatgatt 1516801 cctttcgctt tttagataaa atgaggttga ttccatacag gggagttggt cagcaaaatc 1516861 aatttttatt atgcgttaaa ccggatcacg taacgattat gacaaaagaa gaaatgattt 1516921 ctgcagataa atgtttaatc ggtatcagca caacaaagct gtcggcagat ggagagtttg 1516981 acgcgattat tcatccgaaa atgctttcgg gcaaggctgt caaacacgtt tcataatgtt 1517041 cgcaaatgtc cgttacttat catactcaaa cggcgtgaca tttagaaggg agaggaagat 1517101 gaaaaaactg aaattacggt tgacgcacct ctggtataag ctgctgatga aacttgggct 1517161 gaaaagtgat gaagtctatt acataggcgg gagtgaagcc ctgccgcctc cattatctaa 1517221 agatgaggag caggttttgt taatgaagct cccaaacggc gatcaggcgg cgcgcgccat 1517281 tctaattgaa cgcaatttgc gtctggtcgt atatatcgcc cgtaaatttg aaaatacggg 1517341 aattaatata gaggatttaa tcagcatcgg taccatcggt ctaatcaaag ctgttaatac 1517401 atttaatcca gaaaagaaaa tcaagcttgc tacctatgcc tcccggtgta tagaaaatga 1517461 aatcctgatg tatttaagaa gaaataacaa aatccgttca gaggtttcct ttgatgaacc 1517521 gcttaatatt gattgggacg gcaatgagct tttgctttct gatgtgctcg gcactgacga 1517581 tgacatcatc actaaagaca tagaagctaa cgtcgataaa aagcttttga aaaaagcgct 1517641 tgaacagctt aatgagagag aaaagcaaat catggagctg cggtttgggc ttgtcggtga 1517701 agaagaaaaa acccaaaagg atgtagcgga tatgatgggg atttctcagt cttatatttc 1517761 gcggcttgag aaaagaatta taaaaaggtt gagaaaagag ttcaacaaaa tggtgtaaaa 1517821 aattttatgg ttagaacccc ttgattttac agggatttcc tgatttcgac agtttttcgg 1517881 tctgagtgca gtgcatattt ttcccaccca aggagatact taacgttgta cagcagctcc 1517941 tgtagggagg gaaaaaagtg tcgagaaata aagtcgaaat ctgcggggtg gatacctcca 1518001 aattaccagt actcaagaat gaagagatga gaaagctgtt taggcagctg caggatgaag 1518061 gcgatgattc agcaagagaa aagcttgtaa acgggaactt gcgtcttgtc ttaagtgtca 1518121 ttcaacgatt taataacaga ggggagtatg ttgatgactt atttcaagtc ggctgcatcg 1518181 gactaatgaa atccattgat aattttgacc taagccacaa tgttaagttt tcaacatacg 1518241 ctgtacctat gattatcgga gagatccgca ggtatttacg tgataataac ccgatccgtg 1518301 tctcaagatc actccgggac atcgcttaca aggcgcttca ggtaagagag cggttaatca 1518361 gtgagacaag caaggagccg actgcagaag acatcgcaaa agttcttgaa gtaccgcatg 1518421 aggaaattgt atttgcgctt gatgccattc aggatccggt ttctctattt gaaccgatct 1518481 ataacgacgg cggagacccg atctatgtga tggaccaaat cagtgatgag cgtaatacag 1518541 attcacaatg gattgaagag ctggctttaa aagagggcat gagaaggctg aacgataggg 1518601 aaaaaatgat tttgagaaag cgattcttcc aagggaaaac ccaaatggaa gtcgccgagg 1518661 aaatcggaat ttctcaagcg caggtgtcca gacttgaaaa agcggctatc aaacaaatga 1518721 ataaaaatat tcatcaataa tgaaaagcct ttaaaacgat gttgttttaa aggcttttct 1518781 attgattatg gatggtttac gttttggaaa aagtaaggta tcctagttcg tacaaagttt 1518841 tatgaaaatt aaaacaatta taaaaggcaa taaagaggag gaccacgatg attttgcagc 1518901 ttgacaatgt ctcactaaaa cggaatggga aatggatact gaaagatatt cattggaagg 1518961 tggaagaaaa ggaaaattgg gtgctttacg gcctaaatgg cgccgggaag acagcgctgt 1519021 taaatatgct ttgctcatat tattttccaa catcaggcga gatgcaggtg ctcggccatg 1519081 aatttggcaa aacagagctt ggggaaaagc tcagacgtaa aattggcctc gtctcagcag 1519141 ctcttcagca aaaattgtat ccggcagatt cagcttttga aattgctttg agcggagctt 1519201 acgcttcgat tgggttatat gaaacgccaa gtaaggaaac cagggaaaaa gcgataggtt 1519261 tgttagagga cttgggagca attgaatatg ccgatcgccg ctatgaaacc ctttctcaag 1519321 gggaaaaaca aagagcattg attgctagag cactaatggc cgatccggag ctgctgatac 1519381 tggatgaacc agtcacagga ctggatttta ttgcccggga aaagctgtta gatacgatta 1519441 catacattgc aaacaaagaa aatgcaccat ctatccttta tgtgactcat catgctgaag 1519501 aaattttgcc tgtctttgat aaagcccttt tattaaaaca gggagaggtt tttggatccg 1519561 gagaaataaa ggaaatgctt actgatcaaa tactttccgc tttttttgat acgccaatcc 1519621 atgtattatg gaatcaggat cggccgtttt taacaagagc tgagccgata acgaatgcct 1519681 gacaaatata tatagattca tcctaggggt gctttgcgaa gctgagagag actttgtctc 1519741 aacccttttg acctgatctg gatcatgcca gcggagggaa gcggtgaaaa gcggagtaca 1519801 tcggactccg tttgttttta ttaagccgtt tcatcacatt tgaaacggct tttttgattt 1519861 taaagaatag gagcggattt acattggatc aacaaatata ctctttgcaa aaaaaagtgg 1519921 aagaacataa ggaggagctt attcagcttg cgaaaacgct gatttcttat caaacacctg 1519981 ctccgcctgc aagaaataca gagggcattc agtcttggat tgcgggatat ttaaatgaat 1520041 tgggattctc gatcgacaaa tgggatgtgt accctggaga tcccaatgtt gtagggaagc 1520101 taaaaggaac agattcagca gattattata gcctgattat caatggccat gtagatgtgg 1520161 cagaggtaaa agaggatgaa gaatggaagc acgatccgtt tcatcccatt gaaaaaaacg 1520221 gtctcttaat cgggcgaggc gcttccgata tgaagggcgg aatggcttgt gtgctgtttg 1520281 ctgtcaaatt aattcgtgaa gcaagcattg aacttccagg tgatctgatt ctgcaatcgg 1520341 ttattgggga ggaagttgga gaggccggca cacttgaatg ctgcaagagg ggctaccacg 1520401 ctgattttgc aattgtcgcg gatacgagcg atatgcatat tcaaggccaa ggcggtgtca 1520461 ttacaggctg gatcgaaatc aaaagcagtc aaacatttca tgatggaacg agacggaata 1520521 tgattcatgc aggcggagga acattcggag caagcgcaat tgaaaaaatg gcaaaaatca 1520581 ttgcggggct cggtgaactt gagcgccact ggtctattat gaaaagttat cccggtttta 1520641 aaccaggcac aaatacgatt aacccggcag ttatagaagg cggcagacat gcggctttta 1520701 tagcggacga atgccggctg tggatcacag tccattttta tccgaatgaa acccatgacc 1520761 aagtggcagc ggaaatagaa gattacgtca atcggctgag tgacagtgat atttggctta 1520821 gggaaaaccg ccctgtattc aagtggggag gctcatctat gatagaagac aggggagaaa 1520881 tttttccggc attggaagtt gaccctggcc acccaggcgt cttagcgcta actgcctctc 1520941 atcagaaagt gaaacgggag tgtccaatta ttgacgtttc tcaatcagtt acagatggcg 1521001 gatggctgta tgatgccggt attccatgcg taatatacgg tcctggagat ctgcacaatg 1521061 cacactctgt gaacgagaag gtatcgattg agcagctagt agagtataca aaaattatac 1521121 tcgattttat catcagctgg tgcagccgga aaaaagaaca atgacatgaa aatttcttct 1521181 tgctgacaag gttcagcctg cccgttcata tacttgaaca aaaggacgga aaaaggacgt 1521241 gatggaatga tcagcatttc agaatttcag gtaaaggatg tcgtcaatgt ctcaaacgga 1521301 aaaaagctgg ggagtattgg tgatattgat atcaatgtga ccactggaaa aattcaggcg 1521361 atcatactcg gaggaaatgg gaaagttctc ggattttttg gaaaagaaga ggaattggtc 1521421 attccatggc gaaatatagt aaaaatcggg gaagatgtaa tcttagtccg attaagtgaa 1521481 ccacatgcat aaacctgctt gtctgccgca gattggcaaa tgccggaagt ctcgattctt 1521541 ccggcacatt tcatttagaa atatgcaaat cggcgctcaa cgaatgcagt aagatgtggt 1521601 aaaataagtg ggaaattccg cttttttaaa tgtttgtcga aaggttggat catcatgaat 1521661 acatatcacc cattcagtct taccacaccc tcgacactca tgatacaaga ctgggctcaa 1521721 acgaatcaaa acaacaaaga ggtcattgcc ggatttacga caaaaaacgg cggtgtcagc 1521781 caaaagcctt ttgaatcgtt aaatacagga ttgcacgttc atgacaaaga tgcagatgta 1521841 gttaaaaatc gtgaatatat tgccgatatg tttaatactg atttgcagtc ttgggtattc 1521901 gctgatcaga cacatgataa tcgcgttcag aaagtgacgc agagggatag gggaaaaggc 1521961 gcccgtgagt atcacacggc tctaaaagca acggacggga tctatacaaa tgaaaaaaat 1522021 gtatttttag cattatgctt tgctgattgt gtgcctcttt tcttttatga tccggttaag 1522081 tcgcttgtcg gagtcgccca tgccgggtgg aaaggcaccg tcaaacagat tggcagagaa 1522141 atggtgaagc aatggactga gaaggaaggt tcaaatccct cagatattta cgctgttatt 1522201 ggcccgtcta tcagcggagc atgctatacg gtagacgacc gcgtcatgga tgctgtccgc 1522261 gcattgccgg tttcagcaga ccttgccgcc aatcagacgg caaaggcaca atatcagctt 1522321 gatctgaaag agctgaaccg tcttatactg atggacagcg gtttggcaag tgaacaaatt 1522381 tctgtcagcg gtttatgcac ggaaagcgag ccgtctcttt tctattctca tcgccgcgat 1522441 caggggaaaa ctggacggat gatgtccttt atcggaatga aggaggcata aaagatcttg 1522501 cgtgttgttg ataatttacg acatataaac gaacgaataa acgaagcatg taacagatcg 1522561 ggccgcagct ccgatgaagt tacggttatt gcagtcacaa aatatgtatc acctgaaaga 1522621 gcacaggagg cagtagatgc tggcatcacc tgcctcggag agaatcggga tgcggaactg 1522681 ctccgcaaac aggaattgat gaaagggaat ccggaatggc attttatcgg cagtctgcaa 1522741 tcaagaaaag caaaatctgt cgtcaattcg gtttcctata tccattccct agaccggctc 1522801 tcattagcga aagaaattga aaaacgggct gaaggtactg tacgatgctt tgtgcaggtc 1522861 aatacctctc ttgagccttc taaacatggc atgaaaaaag aagaagtcat tccattcata 1522921 caggagcttt ccggtttcga acatatcctt gttgccgggc tgatgacaat ggctccgctg 1522981 actgatgatc aagatcagat cagaagctgt ttcaggtcgc tgagagaact ccgtgaccag 1523041 gttcagaagc tgaaccagcc gaacgctccg tgtactgaac tgtcgatggg catgtcaaat 1523101 gattttgaaa ttgcaattga agaaggagct acttatatta gaatcggctc atcgttagtc 1523161 ggaaatgaaa cagggggtgt acagcaatga gtatgaaaaa taaactgaaa aactttttct 1523221 caatggaaga tgaagaatac gaatatgaat atattgagac agagcgggaa tctcatgagg 1523281 agcatgagca aaaagaaaag ccggcttaca acgggaataa acctgcgggc aaacagaatg 1523341 tagtgagctt gcaaagtgtt cagaaatcct ctaaagtggt gttgagtgag ccgcgcgttt 1523401 atgcggaggc gcaggaaata gccgaccatt tgaagaaccg gcgggcagtt gtcgtcaatc 1523461 ttcagcggat acagcatgac caggcgaagc ggattgttga ctttttaagc ggaaccgttt 1523521 atgccattgg cggcgatatt caaagaatcg gctcagatat tttcctctgc acgcctgaca 1523581 acgtagatgt atcaggcaca atttctgagc tcatatctga agacgaacat cagaggtggt 1523641 aaagcgagat gatcctttat caagtttttt cggttttaag cttattaatc acaatatact 1523701 catttgccct gatcatatat atttttatgt catgggtgcc gagtacgagg gaaacagcag 1523761 tcgggcgttt tttggcttcg atttgtgaac catatctcga accattcaga aaaatcatcc 1523821 ctccgattgc aatgctggat atttcaccaa tcgtagcaat acttgtgctt cggtttgcga 1523881 caaccggctt gtggggactt tatcgcatga ttgcgtttta atgtgacagt ttgatagggg 1523941 cttggcagca gccaagcctc tttacataga agggaaagac gatgagcgat atatatcagc 1524001 acttcagaaa agacgagcgg gcctttattg atcaagcgct cgaatggaaa agaattgtcc 1524061 aggagcagta ccggatgaag ctgaccgact ttttagatcc ccgagagcag gtcatcctct 1524121 ctgctgttac gggacaggca gatgtcgggc ttgccttttc cggcggctat gacagagcgg 1524181 agcggaaacg ggcgattctg tttccagagt acattactcc ggaagaatca gattttgaac 1524241 tgcaggcgtt taacgtccgt tatgctgaca agtttgtctc agtagatcat cgttctctgc 1524301 ttggtgcatt aatgggcata ggattaaagc ggcaaaaatt cggtgacatc gtgttttctg 1524361 agacagcagt gcaattgatt gtctcagccg ataccgctga ttttgtggct gcacagctga 1524421 cccaagcagg caaagcggcg gtcagcctag agaaaatcga cttgtcagac cttaacattc 1524481 cagcagttga tgtcgaaata agagatgaca cggtttcttc tttaaggctt gacgccgtct 1524541 gcgcctctat gagcaggcaa tcccgccaga aatcacagac gcttgtgaaa aacggccttg 1524601 tgaaagtgaa ctggaaggtg gttgaagatc cttcatacat agtcgcggaa ggggacatgc 1524661 tgtctatcag aggttttggc cggtgcagct taacaaaaat cgaaggaaaa accaaaaaag 1524721 acaaatggag agttacgttt gaacgacaaa aatagtcggt ttttcagttt ttttctccat 1524781 ctgtgcgaaa tttgttttat aatgtgaact agataaccgt actgaaatgt aaaaatggag 1524841 gtggcatcat gccattaacg ccaaatgata ttcacaacaa gacgtttaca aaaagttttc 1524901 gcggatatga tgaagatgaa gtaaatgaat tcctagccca agtcagaaaa gattacgaaa 1524961 ttgttctccg caagaaaact gagcttgaag cgaaagtcaa tgagcttgat gaaagaatcg 1525021 gacactttgc caatattgag gagacattga ataaatcaat tttagttgct caagaagcgg 1525081 ctgaagacgt aaaacgcaat tctcaaaaag aagcaaagct gatcgttcgg gaagcggaga 1525141 aaaacgctga tcgcattatc aacgaatcgt tatcaaaatc aagaaaaatt gcaatggaaa 1525201 ttgaagagct gaaaaaacag tctaaagtgt tcagaacacg tttccaaatg ctgattgaag 1525261 ctcagcttga tcttctgaaa aatgacgatt gggatcatct ccttgagtat gaagtcgacg 1525321 ctgtatttga ggaaaaggaa taaattctct gattatcttg acattttctt agcttgtcga 1525381 atataatacg ttcataaatt cagatgaaaa aacggttgaa agggacagtc atgtttcctt 1525441 caggccttca tagcgacccg gagatggtga gagtccggga tggccggaat catgtagatc 1525501 agccctttag tttccttgct gaactcacag taggttagga cgttcatcac gttacgatgc 1525561 tcaagaggaa aaagtgtatg cttgcttttt ctaaaagggt ggtaccgcga gataagcttt 1525621 ctcgtccctt atgggatgag agggcttttt ttattttctg aaaaaatgca gtggaggaat 1525681 gaaaatggat tttaaagaca cgctcttaat gccgaaaaca gatttcccga tgcgtggaaa 1525741 tttgccaaac cgtgagcctg acattcaaaa aaaatgggag gaagaagata tctaccgtct 1525801 tgttcaggaa cggacgaaag accgcccgaa atttgtttta catgacggac ctccgtatgc 1525861 aaacggcgac atccatatgg gccatgcact taacaagatt ttgaaagact tcattgtccg 1525921 ctataaatca atgagcggct acaacgcacc gtatgtgccg ggctgggata cacacggatt 1525981 gccaattgaa acagctctga caaaaaacaa aaaggtcaac cgcaaagaaa tgtcagtagc 1526041 ggaattccgc aaactatgcg aagagtacgc ttggaagcaa atcgagggac agcgtgagca 1526101 attcaaacgt cttggtgtcc gcggtgactg ggaaaaccca tatgtgacat taaaaccgga 1526161 atacgaagcg cagcaaatcc gcgtatttgg tgaaatggca aaacgaggct acatttacaa 1526221 aggccttaaa ccggttaact ggtcaccttc aagtgagtct gctctggctg aagccgagat 1526281 cgaatatcaa gataaacgtt cagcatctat ttacgtcgct tttggtgtaa aagacggaaa 1526341 aggcgttctt gaaaacggcg agcgcatcat catttggaca acaacgccgt ggacaattcc 1526401 ggcgaacctc ggaatctcag tgcaccctga tcttgagtac agcgtgattg cagtaggtga 1526461 agaccgcttt gttgtagcaa gtgccttagt cgaaaatgtt gcatcggcat gcggatttga 1526521 tcagtatgaa gtgacaagaa cggtcaaagg gaaagacctt gagaacatta tcgctgaaca 1526581 cccgctatat ggcagagact ctctcgttat gcttggtgaa cacgtaacaa ctgatgccgg 1526641 aacaggctgt gttcatacag cgcctggaca tggggaagat gactttatca tcggccaaaa 1526701 atacggttta gatgtgcttt gcccggtcga tgaaaaaggt gtaatgacaa gcgaagctcc 1526761 tggctttgaa ggcatgttct atgatgatgc aaacaaagcg atcacacagc agcttgatga 1526821 aaaaggcgca cttgtgaagc ttgaattcat tactcattct tatccgcatg attggagaac 1526881 aaaaaaacca accattttca gagcaacagc gcaatggttt gcgtctatta aagatttcag 1526941 atcagacctg ctggatgcca ttaaagaaac caaatgggtt cctgaatggg gcgagcagcg 1527001 tttgcacaac atggttcggg accgcggaga ctggtgtatt tccagacagc gtgcgtgggg 1527061 tgtgccgatt ccggtatttt acgctgaaaa cggagaaccg gttattacag atgaaaccat 1527121 tgaacatgtt tctgaattgt tcagacagca tggatcaaac atttggtttg aaaaagaagc 1527181 aaaggatctt cttccggaag gctttacgca tcctggcagc ccgaacggca catttacaaa 1527241 agaacaggat atcatggatg tttggtttga ttcaggctct tcacatcaag cagtgcttga 1527301 agaacgtgat gacctcgttc gcccggctga tctataccta gagggatctg accaatatcg 1527361 cggctggttt aactcttctc tttctacagc agtagccgta acagggaaag cgccgtataa 1527421 aggtgtgctc agccatgggt tcgcactgga tggagaagga cgtaagatga gtaaatcaat 1527481 cggtaacgtt gttgttccgg ctaaagtcat gaaacagctt ggtgccgaca tcttaagatt 1527541 atgggtatct tcagtggatt atcaggcgga cgttcgcgtg tctgacgcca ttctgaagca 1527601 ggttgcggaa gtatatcgta aaatccgcaa cacgttccgt ttccttcacg gcaacctttt 1527661 cgattttgat ccaaaaacaa atgcggtggc tgtcgaagat cttcgcgaag tggatcagta 1527721 tatgctgatt aagctgaaca agctgattga taaagtgaaa aaagcgtatg atgagtacga 1527781 atttgcggtt gtgtatcaca gcattcataa tttctgcaca atcgaattga gctcattcta 1527841 ccttgatttt gcaaaagata ttgtctacat cgagcatgcg gatcatccgg atagacgcag 1527901 catgcagaca gtattctacg aaacgcttct tgcattagtg aagctttcag cgcctatcct 1527961 tccacatacg gcagacgaat tgtggtctca tttaacattt gttgaagagc agagcgttca 1528021 gttgaccgat atgccggaaa caatcacggt tccaaacagt gaagcgactg aagaaaaatt 1528081 tgaccgcttt atggctcttc gtgatgacgt gttaaaagca ttagaaactg cgcgaaatga 1528141 aaaaattatc ggtaaatctt tggaagcaaa cctgaaattg tatccaaaca aagaaaacaa 1528201 ggagctcttg gcttccataa aagaaaacct ttctcagctg tttattgtgt ctgaactgac 1528261 aatcagcgaa gaaaatgaag cgccgaacga tgcgcaaagc tttgcgacgg gtaaaatcgc 1528321 tgtcgagaaa gcggaaggcg aaatgtgtga gagatctcgt gtgatttcaa aagatgtagg 1528381 ggcaaatccg aaatatccta cactttcatt acgcaacgct gaaatcgttg aaaaatacta 1528441 tcaaaaataa tgcaaaagag cccggcgtaa aagccgggct ttttttgtgc caagagtgac 1528501 atcctttaga acgaaaggaa aaatcttatg ggctttagat catcattcac aggcaacaat 1528561 aaagatacta cgttaagagc aggagttgtg aagaatgaat gatcaactga ccgcaattta 1528621 tacggaactt cttctgatga aagaagaatt acagtcgaga ttatttgagt attcttgctt 1528681 tcaggtttct acaagcccgc aagcagcaat caatcaaaaa caaaaagcaa ctctgatcta 1528741 tcatattaaa gaagaacttc aagacgttct ccttgcattg tccaaaatcg aaaacggcac 1528801 attcggatac tgtgaagaaa ctggggcccc cattcctctt gcaaagctgg cagtgctgcc 1528861 gacggcccga acagcaaacg attttcttta ttctgtccaa tttgagaaaa aaacgcttcc 1528921 gatatggaaa tcaacggata tcgaatatgg tcaggcactg tatgaataac agtgtctgtc 1528981 cggttaatat gcctgatatt tctttactcc agtgcttttt attgataaaa tgcataatgg 1529041 attaaagtaa ccgtaaactg gaggaacgtt tgtgctgtat tatatgattg cactacttat 1529101 tattgcagcc gatcaattga caaaatggct agttgttaag aacatggaac ttggccaaag 1529161 cattccgatc attgatcagg tattctatat cacctcccat cgcaatacgg gtgctgcatg 1529221 ggggatatta gcgggtcaaa tgtggttttt ctacctcata acaaccgctg ttattattgg 1529281 tattgtttat tacatacagc gttatacaaa gggacaaagg cttcttggcg ttgccctcgg 1529341 acttatgctt ggcggtgcca tcggcaactt tatcgatcgg gctgtcagac aggaagttgt 1529401 ggattttatc catgttatta ttgtcaatta caattacccg atatttaaca tcgcggactc 1529461 ttcactatgt gtcggcgtaa tgcttttatt tatacaaatg ctgttggaca gcgggaaaaa 1529521 gaaaaaggag caatagcatg aatcaaattg atataaccgc ttcagaagaa caaaaaagtg 1529581 agcggattga taaatttttg gcatcgactg agaatgattg gtcaagaacc caggttcagc 1529641 aatgggtaaa agacggacag gttgtcgtga acggaagcgc ggtgaaagcg aattataaaa 1529701 ttcagccggg tgatcaggtg accgtcactg tacctgaacc ggaagcgctc gacgtcctgg 1529761 cagagcctat ggatctggat atttattatg aggaccagga tgtgctggtc gtcaacaaac 1529821 ctcgcggaat ggttgttcac ccagcacccg ggcatcttac gggcacactt gtaaacggtc 1529881 ttatggctca ttgcacagac ctttccggaa taaatggtgt gatgcgcccg ggtattgttc 1529941 acagaatcga taaggacacg tccggtttat taatggtggc gaaaaatgat atggcgcacg 1530001 agtcactcgt aaaccaattg gtcaacaaaa cggtcacgcg gaaatatacg gcggttgtcc 1530061 acgggcttat ttctcatgat gacggcacaa ttgacgcgcc gatcggacgg gataaaaaag 1530121 accgtcaaag catgactgtg acacgtgatg gcaaaaacgc tgtcactcat tttcatgtgc 1530181 ttgagcgttt tcaggatttt acgttagtgg agtgccagct tgaaacaggg agaacccatc 1530241 aaattcgtgt tcatatgaaa tatatcggat tcccattagc aggcgatccg aaatacggcc 1530301 caagaaaaac aatcgacttt aatggccaag cgcttcacgc gggagtttta ggttttgacc 1530361 atccacgaac aggagaatat gtcgaatttg aagcgccgct tcccgaggat atggcagaat 1530421 taatcgaaaa cctcagaaaa aacggttgac agagggtttc ttttctgaaa taataaacga 1530481 agctgaatag attctttaaa acagtccaga gaggctgaga aggataacgg atagacggga 1530541 tgcgtgtata ggcgcgcacc ttgtcctaaa acccctctat gctctggcag gaggggtttt 1530601 ttcttctata tgaactgtga ggtgtcacac attgaatcaa aaagctgtca ttctcgacga 1530661 acaggcaatt agacgggcgc tgaccaggat tgctcacgaa atgatcgaac gcaataaagg 1530721 aatgaataac tgcattcttg tcggcattaa gacaagaggg atttacctgg caaaacgcct 1530781 tgcggaacgc attgaacaga ttgagggaaa tcctgttaca gtcggtgaaa ttgatattac 1530841 tctttacaga gatgatcttt ctaaaaaaac aagcaacgat gaaccgcttg taaaaggtgc 1530901 agatattccg gtagatatta cagatcaaaa agtcattctc gttgatgatg ttctgtatac 1530961 cggaagaaca gtcagagcag gaatggatgc gcttgttgat gtaggcagac cttcctccat 1531021 tcagcttgca gtgcttgtgg acagaggaca ccgggagctg ccgatccgag cggattatat 1531081 cgggaaaaac atcccgacat caaagtctga aaaggttatg gtacagcttg atgaggtaga 1531141 ccaaaacgat ctcgtcgcca tttatgaaaa cgaataatag atcacctttt taagggcaat 1531201 ccagagaggt tgcaaagagg tgcacaacaa aggcccaaaa agtattcggc aggtctttgt 1531261 atgcctcttt gcgtaaaaaa gcaaagaggt ttttttatac agtcattgag tcatcctaaa 1531321 atgaaagtca acaatcaggg ggaaatcatc atgagtaaga aaaaagtaaa tttaggggtc 1531381 agggatgtcc cgacaccttt ctcttgggtt tcattcagcc ttcagcattt gtttgccatg 1531441 tttggctcaa ccattttggt tccgaagctc gtcggaatga gtcctgctgt ggcgttggtg 1531501 acaagcggca tcggaacact ggcgtacctt cttattacca aaggacaaat tccggcgtat 1531561 ctcggttcat ccttcgcctt tatttctccg atcattctgg taaaagcgac cggcgggccg 1531621 ggagcggcaa tggttggagc gtttcttgca gggctggtgt acgggctgat tgccttattg 1531681 attaggcagc ttggaacagg atggctgatg aagattctcc cgcctgtagt cgtagggcct 1531741 gttattatcg tcatcgggct gggactggca agcactgcag taaacatggc gatgtatgct 1531801 gatccgaacg cgagtgagtt ggtctacagc ttaaagcact ttagtgtcgc aggagttacg 1531861 ctggcaatta cgattatttg tgcgattttc ttacgagggt ttttaagcct gattccggtt 1531921 ctgatcggaa tcatcggcgg atacctgttt gcccttactc aagggattgt caacttccag 1531981 ccggtgcttg acgcgaaatg gtttgcagtg cctgaattta tcattccgtt caaagattat 1532041 tcaccgtcag ttacgctcgg catcgcagcc gcaatggttc ctgtcgcatt tgtcacaatg 1532101 tcagagcata tcggccacca aatggtgctg agcaaggttg tcggacaaga cttcattaaa 1532161 aagccaggtc ttcatcgctc tattatgggt gacagtgtgg cgacaatcct cgcttccctg 1532221 atcggcggcc ctccgacaac gacttacgga gaaaacattg gcgtgctggc catcacaaga 1532281 gtattcagcg tctttgtcat cgggggcgcg gcagtgattg ccctttgctt cggctttatc 1532341 ggcaaaattt cagcgctgat cagttcagtg ccgtcagcgg tcatgggagg cgtctccttc 1532401 ctgctgttcg gaatcattgc ttcaagcggc ctgagaatgc tgattgacaa caaaattgat 1532461 tatgaaaaca acagaaacct cattattaca tcagttatcc ttgtcatcgg tgtaggaggc 1532521 gcttttatcc aagtgtctca gggcggattc caagtgtcag gaatggcgct tgccgcaatt 1532581 gtcggtgtca tcttaaacct gattcttccg caggcgaagg aagagcaggc agacacatct 1532641 gaacaacatc atatttaaaa ccttttaatg aaagtccaga gaggcttgga agggttatga 1532701 agagaaggaa gcttcaatgc tgccctctat ttaaccatac cccgagtcta tcttagaccg 1532761 gggttttttt tcagccttaa gttgaaaaga gaggggaaag aacatgaagc atttaacgac 1532821 gatgagtgaa cttagcactg aggaaatcaa agatttgctt caaacagcac aagagctcaa 1532881 aagcggaaaa acagacaatc agcttacagg aaagtttgca gcaaacctgt ttttcgaacc 1532941 gagcacgaga acgcggttca gctttgaggt cgcagaaaaa aagctgggca tgaatgtgct 1533001 taaccttgat ggaacaagca caagcgtgca aaaaggcgaa accttatatg acacgatccg 1533061 gacgcttgaa tcaatcggtg tggacgtctg cgtcatcagg cacagtgagg atgagtatta 1533121 tgaagagctt gtcagccagg tgaacattcc gattctgaat gcgggagacg ggtgcggcca 1533181 gcatccaaca caatcactgc ttgatttaat gacgatttat gaagagttca atacgtttaa 1533241 agggcttacc gtctccattc acggcgacat caagcatagc agagtggcaa ggtcaaatgc 1533301 ggaagtgttg acaagattgg gtgcccgggt cctattttcc ggcccttcgg aatggcagga 1533361 tgaagaaaat acattcggca cgtatgtctc aatggatgaa gcagttgagt cttccgatgt 1533421 tgtcatgctg ctgcgcattc aaaatgaacg acatcagtcc gctgtcagtc aggaaggcta 1533481 tttaaacaaa tacggcttga ccgtagaacg ggctgagcgt atgaagcggc atgcgatcat 1533541 catgcatcct gctccggtaa acagaggagt ggagattgat gacagcttag tagaaagcga 1533601 aaaatcaaga atcttcaagc aaatgaaaaa tggcgtattt atcagaatgg cagtgataca 1533661 gcgtgcctta caaaccaatg tgaaaagagg agaagcagcg tatgtcatat ctcattaaaa 1533721 acggctggat actaaacgaa aatggtgaaa aaacacaagc ggatatccga gtgactggag 1533781 aaaccatcac cgcaatcggc aagcttgatg caacggataa tgaaacggta attgatgcaa 1533841 aaggtttgct cgtttcacct gggtttgttg atctccacgt gcatttcaga gagccgggcg 1533901 gagagaaaaa agaaactatt gaaaccgggg caaaagcagc ggcgcgcggc ggctatacta 1533961 cagtagcagc aatgccgaat acgcggccgg ttcctgatac aaaggagcag atggaatggg 1534021 tgcaaaacag aattaaagaa acatcatgcg taagagttct tccatatgca tccattacga 1534081 tcagacaaat cggcgatgaa atgacaaact ttgaagcgtt aaaagaagcc ggggcatttg 1534141 cttttacaga tgacggcgtt ggtatacaga cagcaggaat gatgtatgaa gcgatgaaac 1534201 gggcagccgc aattgacaaa gcgattgttg cacattgcga ggacaactcc ttaatttacg 1534261 gagggagcgt acatgagggg acattctcca aagcgaacgg gctaaacggc attccttctg 1534321 tgtgtgaatc ggttcatatt gctcgcgatg tgctgctggc tgaggcggca aactgccatt 1534381 atcatgtatg ccatatcagc acaaaagaat ctgtcagagt tgtacgcgat gcgaaaaaag 1534441 cgggaatcag agtgacagca gaagtatcgc cgcatcattt gctgctttgt gatgaggaca 1534501 tcccggggct ggacacaaac tataaaatga atcctccgct ccgcagccca gaagacagag 1534561 ctgctttaat tgaaggtctt ttagacggaa caattgattt tatcgcaaca gaccatgcac 1534621 cgcatacgga agaagagaag aacacagaaa tgaagctggc gccattcgga attgtcggct 1534681 tagaaacagc attcccgctt ctttacacac actttgtcaa aaatggcagc tggtcactga 1534741 agcagctgat tgactacatg acaatcaagc catgcgaagc gttcggtctc ccatatggaa 1534801 cattacaaac ggggcaagct gcggacatta cgttaatcga tttagaaaaa gaagcagtta 1534861 tagacaaaga gacattttta tcaaaaggaa aaaatacacc attcaacggc atcagttgca 1534921 ccggctggcc ggtcgctaca attgcggcag ggaagcttgc ttatgaagag gggagacttg 1534981 tcaaatgaag agacgattag tactggaaaa cggagcggta ttcgagggag aagctttcgg 1535041 aagcttagaa cacaacatgg gagaagtcgt ttttaatact gggatgacag gctatcagga 1535101 aattttatct gatccttctt actgcggaca gatcgtaaca ttaacatacc cgcttatcgg 1535161 aaattacggc attaaccgtg atgattttga atccattacc ccttttgtca aagggctgat 1535221 catcaaagaa ttatgtgagc tgccttccaa ctggcgttca gcatacacct tagacgagta 1535281 tttaaaaatg aaaaacattc ccggactcca gggaattgat acaaggaagc tgacaagaat 1535341 gatccgcacg gcaggcgcgc taaaaggaac attcgcttca tctgatgaag atatcgaagc 1535401 agtgctgaaa agactgaacg aaacggaatt gccaagaaat caagtatccc aagtatcagc 1535461 aaaaacagca tatccgagcc cgggaagagg caaacgcatt gtcttggttg acttcggcat 1535521 gaaacacggg attctaagag agctgaacaa acggaaatgt gacgtcatcg ttgtgcctta 1535581 caacattaca gcggaagagg tgcttcagct gaaaccggac ggtatcatgc tttctaacgg 1535641 acctggagac ccgaaggatg tgcctgaagc gattgaaatg attaaaggtg ttcttggaaa 1535701 agtgccatta ttcggaatat gtctcggcca ccaattattc gcgctggcgt gcggggcgaa 1535761 tactgaaaaa atgaaattcg gccacagggg ctcaaaccac ccggtaaaag agctggctac 1535821 aggaaaagtt gccttaacat ctcaaaacca tggatataca gtttcgtcta tcagtaaaac 1535881 agaactggaa gtgacgcata tcgcaattaa cgacgatacg attgaagggc tgaagcataa 1535941 aacattgccg gcatttacgg ttcaatatca tcccgaagcc tcacctggtc ctgaggatgc 1536001 caaccatcta tttgacagat tcatcgaaat gatcgaaaca acagagaaag aaggggaagc 1536061 ggtatgccaa aacgcgtaga cattaacaaa attttagtaa tcggatctgg accgatcatc 1536121 atcggccaag cagcagaatt tgactatgcg ggaacacaag cctgtcttgc tttgaaagaa 1536181 gaaggctatg aagtcatcct tgtcaactca aaccctgcaa cgatcatgac agatacagaa 1536241 atggctgacc gggtttacat cgaaccgctc acacctgaat tcctgacacg aatcatcaga 1536301 aaagagcgcc cggatgccat tcttcctaca ctcggaggcc aaaccggttt gaatcttgcg 1536361 gttgagcttt ctgaaagagg cgttttggca gaatgcggcg tcgaagtgct tggcacgaaa 1536421 ctgtctgcga ttcagcaagc tgaagaccgt gacttgttca gaacattaat gaatgaactg 1536481 aatgaaccgg tgcctgaaag tgagattatc cactcccttg aagaagcaga aaaattcgtc 1536541 agtcaaattg gattccctgt cattgtccgc ccggcatata cattaggcgg aacaggcgga 1536601 ggcatctgct cgaatgaaac agagctaaaa gaaatcgttg agaacggctt gaaattaagc 1536661 ccggtacacc aatgtctgct tgaaaaaagc atcgccggct ataaagaaat cgagtatgaa 1536721 gtcatgagag acagccagga tcacgccatt gtcgtttgta acatggaaaa cattgatcca 1536781 gttggaatcc atactggaga cagtattgtt gtcgcgccga gccaaacgct cagcgatcgc 1536841 gaatatcagc tcttgcggaa tgtatcgtta aaactgattc gcgcgcttgg gatcgaaggc 1536901 ggatgtaatg tccagctcgc cttagatcca gacagcttcc aatattacat tattgaagta 1536961 aatccgcgtg tcagccgttc atctgccctt gcatcaaaag caacggggta cccgattgca 1537021 aagctcgctg ctaaaattgc agtcggactt tcattagatg aaatgatgaa cccggtgaca 1537081 ggaaaaacat atgcagcatt tgaacctgct cttgactatg tcgtatccaa aattccgcgc 1537141 tggccgtttg ataagtttga atcagcaaac agaaagcttg gcacgcaaat gaaagcgaca 1537201 ggtgaggtca tggcaatcgg ccgcacgctt gaagagtcat tgctgaaggc agtgcgatca 1537261 ctggaagcgg atgtgtatca tcttgaattg aaggacgccg ctgacatttc agatgagctt 1537321 cttgaaaagc gaattaaaaa ggccggtgat gaacgcttat tctacttagc tgaagcgtac 1537381 agaagaggct acacggtaga agacctccat gaattttccg ctatcgatgt cttcttcttg 1537441 cataagctgt tcggaatcgt acagtttgaa aaagaattga aggccaatgc gggcgataca 1537501 gatgtgctga gacgggcaaa agaactcggc ttctctgatc agtacatcag ccgtgaatgg 1537561 aaaatgaaag aatctgagct ttacagcttg agaaaacaag cggggattgc gccggtattc 1537621 aaaatggtag atacatgcgc ggcggaattt gagtcagaaa cgccatactt ctatagcaca 1537681 tatgaagaag aaaatgaatc tgtcgttaca gataagaaaa gtgtgatggt gcttggttcg 1537741 ggtccgattc gaatcggtca gggtgtcgag ttcgactatg cgacggttca ctctgtatgg 1537801 gcaattaaac aagcaggcta tgaagccatt attgtcaaca acaacccgga aaccgtttca 1537861 acagacttca gcatctcaga caagctgtat tttgaaccgc ttacgattga agatgtcatg 1537921 cacatcattg acctcgaaca gccaatgggc gttgtcgtac aatttggcgg acaaactgcg 1537981 attaaccttg ctgacgagct ttctgcacgc ggagtgaaaa tccttggaac ttcattagaa 1538041 gatttagacc gtgccgaaga ccgggataaa tttgaacaag cgcttggaga acttggtgtt 1538101 cctcagccgc ttggcaaaac agcgacatca gttaatcagg cggtaagcat cgcaagtgat 1538161 atcggttatc cggtactggt acgcccttcc tatgtacttg gcggccgggc gatggagatt 1538221 gtttaccatg aagaggaact gcttcattac atgaaaaatg cagtcaaaat caatccacag 1538281 caccctgtat taattgatag atacttgacc ggaaaagaaa ttgaagtcga tgcagtatcc 1538341 gacggtgaaa cagtcgtcat tccgggaatt atggagcaca ttgaacgtgc gggcgttcac 1538401 tccggagact caatcgctgt ttatccgcct cagtctctca cagaggacat taagaaaaaa 1538461 attgaacaat acacgatcgc attggctaaa gggctgaata ttgtcggttt gctcaatatt 1538521 caattcgtct tgtcgcaagg cgaggtgtac gtgctagaag tgaatccgag atcaagcaga 1538581 accgtaccgt ttttaagcaa aattacgggt atcccaatgg cgaatctcgc aacaaaaatc 1538641 attcttggtc aaaagctggc tgcgtttggc tatacagagg gccttcagcc tgaacagcaa 1538701 ggtgtatttg taaaagcgcc ggtcttctcc tttgccaagc tgagaagagt ggatattacg 1538761 ttagggcctg aaatgaaatc aacaggtgaa gtcatgggga aagattcgac acttgaaaag 1538821 gcgctctaca aagccttgat cgcttcaggt attcaaatcc cgaactacgg ttccgtgctt 1538881 ttaacagtag ctgataagga caaagaagaa gggcttgcca ttgctaagcg gttccacgcg 1538941 atcggctaca acattttagc gacggaagga acggcaggct acctgaaaga agcttccatt 1539001 ccagcgaagg tcgtcggaaa aatcggtcag gatggcccga acttgcttga tgtcatcaga 1539061 aacggagaag cgcagtttgt catcaatacg ctgacaaaag gaaagcagcc ggcaagagac 1539121 ggttttagaa tcagacgtga atcagtagaa aatggtgttg cctgcctaac atctttagat 1539181 acggcagagg cgatattgcg agtgctggaa agcatgacat tccgtgctga tcaaatgccg 1539241 gcagtcaaca caaatcagga ggcggcagtc actatatgaa aaaagcgtat ttgacagtat 1539301 gttctaacca gcaaattgca gaccgggtgt ttcaaatggt tctgaaaggg gagcttgtcc 1539361 aagggtttac aacccctgga cagttccttc atcttaaagt gagcgaagcg gttacgcctc 1539421 ttttgagaag gccgatcagc atcgcagacg tcaactttga aaaaaatgaa gtcaccatca 1539481 tttatcgggt agatggggaa gggacaagac tcttgtcact gaagcagcag ggagaacttg 1539541 tggatgtcct cgggcctttg ggaaatggct ttcctgttaa tgaagttcaa cccggaaaga 1539601 cggctttgct ggtaggaggc ggagtaggtg tgccgcctct ccaagagctg tcgaaacgct 1539661 tgattgaaaa aggggtaaat gtcatccacg ttttaggatt ccaatcggca aaggatgttt 1539721 tttacgagga agaatgccgg cagtacggag acacgtatgt ggcaacagct gacggaagct 1539781 acggggaaac cggatttgtc acagatgtga ttaaacggaa aaagctagag tttgatatcc 1539841 tcctcagctg cgggccgaca ccgatgctca aggcgttaaa acaggaatat gcccataaag 1539901 aagtatatct gtccatggag gaacgaatgg gctgcggaat cggcgcatgc ttcgcgtgtg 1539961 tgtgccatac aaacgaaagt gagacatcct atgtaaaagt atgtctcgac gggcctgtat 1540021 ttaaagctca ggaggtggcg ctgtaatgct agaggtgaaa ttgccgggac ttgatttgaa 1540081 aaacccaatc attcctgcat caggctgctt cggttttgga aaagaatttt cacgttttta 1540141 tgatttgtct tgtcttggag ctatcatgat taaggctacg acaaaggagc cgcgctttgg 1540201 gaatccgacg ccgcgggtag ctgagactgg tgctggaatg ctcaatgcga tcggtctcca 1540261 aaatccgggg ctggatagtg tgttgcatca tgagctgccg tggcttgagc agtttgatac 1540321 accgatcatt gccaatgtcg caggttctca agtcgatgat tatgttgaag tcgcagaaca 1540381 tatcagcaaa gcgcctaatg ttcatgctct tgaattgaat atttcctgcc cgaatgtgaa 1540441 aacaggcgga atcgcttttg gcacgaatcc tgaaatggct gccgatttga caaaagcggt 1540501 gaaagaggtt tcggatgtac ccgtttatgt gaagctatcc ccgaacgtgg ctaatatcac 1540561 agaaattgca ttagcgatcg aggaagcggg agcggacggt cttacgatga tcaacacact 1540621 aatcggcatg agactcgatt taaaaaccgg caaaccgata ttagcgaata aaacaggggg 1540681 actttcgggc cctgctgtga agccggttgc cattcgcatg gtgtatgaag tcagccagat 1540741 ggtcaacatc ccgattatcg gaatgggagg cgtgcaaacg gctgaagatg ccctggaatt 1540801 tcttctcgcg ggagcaagcg cagtcgctgt cggaacagca aactttgtga atccttttgc 1540861 atgtccagag attattgaac agctcccatc tgttttgctc caatacggct atcaatcaat 1540921 tgaagaatgc atcggaagga gctggaatca tgaaaaacaa cctgcccatc atcgcgcttg 1540981 attttgcgtc agctgaagaa acacttgcgt tcttagcgcc ttttcagcaa gaaccgttat 1541041 ttgtaaaggt tgggatggag cttttttatc aagaagggcc atctatcgtg aaacaactaa 1541101 aagaaagaaa ctgcgagcta tttttagatc taaagcttca tgacatcccg actactgtaa 1541161 acaaagcgat gaagcgcctt gccagtcttg gagtagacct cgtcaatgtt catgctgccg 1541221 ggggcaaaaa aatgatgcag gcagctctcg aaggcttaga agaaggtacg ccggctggaa 1541281 aaaaacgtcc gtcacttatc gcggtaaccc agctgacaag cacatctgaa caaatcatga 1541341 aagatgaact gctgatcgaa aagtctctga ttgatacggt tgtgcactac agcaaacagg 1541401 cggaagaaag cggactggat ggagtggtct gctctgttca tgaagcaaaa gccatttacc 1541461 aagcggtgtc gccttcattt ctgactgtca ctccggggat cagaatgtca gaggacgctg 1541521 cgaatgacca agttcgcgta gcgacgcctg ccattgcaag agagaaaggt tcatcagcga 1541581 ttgtagtagg acgctcgatt acaaaagcgg aagacccggt aaaagcctat aaggctgtca 1541641 gacttgaatg ggagggaatc aaatcttgaa acaaatcatc gcaaaacatc tattagacat 1541701 ccaagctgta tttttacgcc cgaacgagcc gttcacatgg gcaagcggca ttttatcacc 1541761 gatctactgt gacaaccgcc ttacgctatc tttcccagag gtcagaaacg atgttgcttc 1541821 aggtatcagc aagcttgtta aagagcattt tcctgaagct gaaatgattg cgggaacagc 1541881 aactgccggt attcctcatg ctgctcttgc ggcggaccat ttgaatcttc cgatgtgtta 1541941 tgtgaggagc aagccgaagg cgcacggaaa aggcaatcag attgagggag ctgtgcaaga 1542001 agggcaaaaa acagtcgtca ttgaagactt aatttccaca ggaggcagcg tgcttgaagc 1542061 ttgtgcagct ttacaagcgg ccggctgtga agtgcttggt gtcgtctcaa tctttacgta 1542121 cggacttcct aaagcggagg aagccttcgc aaaggcagaa ctgccatact actcattaac 1542181 cgattatgat acgctcacag aggtcgcgct tgaaaacgga aatattcatt cagatgatct 1542241 aaaaaagctg caaacatgga aacgaaatcc cgagtcaaaa gattggttta aaaaataaaa 1542301 aataaattca aatgatgtaa agaggcttca aagccttgct gtacttgaaa acaggctgtg 1542361 aggcctgttt ttttattaat cctataaaaa aagtcgggtt gacttatgtt agaattgtgc 1542421 taaaatttac tacaaatcta aaaacttatc aagagcggct gagggactgg acctatgaag 1542481 cccggcaacc tgcatagttt gtaaggtgct acttccagca aaatgaattc cattttgaaa 1542541 gataagggct gcatgctgtt cctgtctttc tttccgccgg attgaaagtt ttttatttta 1542601 agaggtaaaa aggctatctg tatatcagca gccgcgaatc acattacatg ggaaaagaca 1542661 accggcagaa agctactgtt tgtttgtctc cgaaaggagg aaagaagaaa tgttaacgta 1542721 tgataattgg gaagaaccaa cgattacatt tccggaagac gatccttata aaggagcgct 1542781 gtcagtttta aaatgggcat acggccatta cggcgatcag cttgtttatg cctgcagttt 1542841 cggaattgag ggaatcgttc tgattgactt aatttataaa gtgaaaaaag acgcagagat 1542901 tgtgtttctt gatacaggac ttcattttaa agaaacctat gaaacaattg aacgagtgaa 1542961 agagcgttat ccgggtctta atatcatcct gaaaaaacca gatctcaccc ttgaggaaca 1543021 agccgaagaa catggtgaca aactatggga aagagagccg aatcagtgct gctatcttag 1543081 aaaggtcgtt cctttaagag aggcgctttc aggacatcca gcctggcttt ccggcctgcg 1543141 ccgtgatcaa gggccaagcc gtgccaatac gaatttctta aacaaagatg aaaaattcaa 1543201 gtcagtaaaa gtttgcccgc ttatccattg gacttggaaa gacatttgga gatatacatc 1543261 ccggaatgaa ctggactaca atccgcttca tgaccaaggc tatccaagta ttggctgtgc 1543321 gccttgcact tctcccgctt ttacagcaga agatttgcgc tcaggcagat ggaatggtat 1543381 ggcgaaaaca gaatgcggac tgcatgaata aggagctgca aaatggaatt agccgctatt 1543441 ttatttagct tgtttttcgc gatgaatatt ggtgcaagcg gcgctgcagc ttcgatgggg 1543501 gttgcttacg gctccggagc catcaaaaag aaaacttacg ctttgatcct atgcgcagtc 1543561 ggtgtctttg ccggggcggt cattggcgga ggcgaggttg taaaaacaat cagctccggc 1543621 attattcctg agcagacgat tacactgacg attgtttgca tcattattgg agctgctgcc 1543681 ctgtcgctct ttactgctaa tctgctcggc attcctttgt cgacaagtga agtaacagtc 1543741 ggcgcggttg tcggcgtggg agtggcttat aaagtattgt ttgtgaacaa tcttctgatc 1543801 attgtgtcat tttgggtttt tgtcccgctg ttcgctttcg gcttcaccta tttcgtatct 1543861 aagctgtttc gttattttaa gattgaagta aaatcttcta aaaagcaaaa aatcctcggc 1543921 attgttttgt tagttgccgg atttttcgaa gcattctctg ccggcatgaa taacgtggcg 1543981 aatgctgttg gcccgttagt agctgccggt gtgcttgatg tcggaaaagg aaccttgtat 1544041 ggaggagctt ttgttgctct tggcgcactg ttattaggcc ggcgagtgct agaaacaaac 1544101 gggaagaaaa ttacgaggtt ctccaaaggg gaaggcattc tcttatccgg tacaggagcg 1544161 ggactggtga tcatcagttc tgtatttggg atgccggtgc ccttggcgca agtcacgtca 1544221 tcgtctatta tcggaatagg catggcgaaa aacggtccga acgtgttcca taaacaagtt 1544281 gttcaaacga tgctgaaggt atggatcgta tcgccgtttt tatctttatc gatttcttat 1544341 ctgcttgtat ccttgttttt aaaagcagat tattattcga tctttatcat ggtaagtgtg 1544401 cttttagcgg cgggcggtgc catcagcctg acaaaggcca ttcgtaaaga gagacgctca 1544461 gtccacgaac aaggcggggg aatctgatca ttaatctgag taattttata agttaactag 1544521 gaggagatgg atattatgag cttagcacca cacggaggaa cattagtaaa cagagtagat 1544581 gaatcatatg atgtgagcgg cattcaaaaa gaaattgaac ttgatttaat ttctttcgcg 1544641 gatttggaat tgatcggtat cggtgcatac agcccgattg aaggtttctt taatgaaaaa 1544701 gattacgtat cagtggtcga aaacatgcgt ctttcttccg gcgttgtctg gtctcttcca 1544761 atcacgcttc cggtcgatgc gcaaaaagca gcggaactgt cacttggtga aacggtaaag 1544821 ttaacgtatg aaggagaaac ttacggcgtt atccaaatcg aagacctgta cgtgcctgac 1544881 aaacaaaaag aagctgtcaa tgtgtacaaa acagatgaac aggagcatcc tggtgttaaa 1544941 aagctgttca gccgcggcaa tacatatgtc ggcggaccga ttacgttgat taaaaaagct 1545001 tcaaaacagt tccctgaatt tacatttgaa ccgtcagaaa cgagacgcca gtttgcggaa 1545061 aaaggctggg aaaccattgt cggtttccaa acaagaaacc ctgttcacag agcgcatgaa 1545121 tacattcaaa aaacggctct tgaaacagta gacggcttgt tcttgaatcc gttagtaggt 1545181 gaaacaaaat ctgatgacat tccagctgat gtacggatgg aaagctacca agtgcttctt 1545241 gatcattatt acccgaaaga tcgtgttttc cttggtgtct ttttagcggc gatgcgttat 1545301 gcaggcccga gagaagcaat tttccacgcg cttgtcagaa agaactacgg ctgcacacat 1545361 ttcatcgtcg gccgtgatca tgcaggtgta ggcgactatt acggaacata cgaagcacag 1545421 gaactgtttg acacatttaa acctgaagaa ctcggaatta caccgctgaa atttgagcac 1545481 agcttcttct gtaaaaaatg cggaaatatg ggaacagcaa aaacttgccc tcatggcaga 1545541 gagcatcacg tcattttatc aggcactaag gtaagaggta tgctgagaga cggtgtgctg 1545601 ccgcctgctg aattcagtcg aaaagaagta gtagaagtgt taatcaaagg gatgaagaaa 1545661 aaagaagaag taggcgtatc ttaaggagga ctggcagtga caaatcgcga tattgtatgg 1545721 catgaagcct ctatcacaaa agaagagtat cagcaaaaaa acaagcataa aagctccatt 1545781 ctctggctga cagggttaag cggctcaggc aaatcaacca ttgccaacgc cgctgcgaga 1545841 gaattgtttg agcaaggcta ccaagtcatt gtgctggacg gggataatat ccgtcacggc 1545901 ctaaataggg atcttggttt ttctgatgaa gaccgaaaag aaaacatccg ccggatcgga 1545961 gaggtggcga agctttttgt tcagcaggga accattgtga ttactgcttt tatctctcct 1546021 ttccgcgagg acagacaaca ggttcgcgag cttgtggaag cgggcgaatt taatgaagtc 1546081 tacattaaat gcgaccttga tatttgtgaa caaagagatc cgaaagggct ttacaaaaaa 1546141 gcaagaaacg gcgagattcc gttctttaca ggaattgatt ctccttatga agaaccggaa 1546201 gctccagagc tcgttcttga ttcaggacag catgaccgtg aagcgtgtaa aaatcagctg 1546261 atcgagtttg ttaaacaaaa attgagctga atatgatctg ctgcgttctt ctcagatgcc 1546321 ggaatgcaag cgagaacatc atcacagcga atcttctgga agaactcgaa tagatcgggg 1546381 gaaatacgat ggggaaagta tatattgtag gagcgggtcc cggtgaccct gatctgctga 1546441 caattaaagc gctgaaagcc attgaaaaag ctgatgtcat cttatatgac agattagtaa 1546501 ataaagagat tttacaatat gccaaagagc aagcagacct gatctactgc gggaagcttc 1546561 cggattttca tacgatgaag caggaaacca tcaatcgatt tcttgtgaag tatgcgcaaa 1546621 aagggaaaat ggttgtcaga ctgaaaggcg gagacccttt tgtgttcggg agaggagggg 1546681 aagaagcgga atgcctctct gaaaatggaa ttccgtttga aatcattccc ggcattacgt 1546741 ctggaatcgc ggcagccgct tatgccggga ttcctgttac ccatcgggat gcgggctcta 1546801 acgtcgcttt tgtaacgggt cactataaaa aagaagaaga ttttgaggaa aagtggaaag 1546861 cgctggctac aggaattgat acacttgtca tctatatggg tatcaaaaac gtgcagcaga 1546921 ttgaaagaaa actccttgaa aatggccggg acggttctac gccagcagcc tttattcatt 1546981 gggggacaac ggacaagcaa aaatctgttt tttgtacagt tgacaccctt tcagaaacgg 1547041 tgataaaaga aaacattaca aatccgagtt taattgtcat tggaaatgtt gtaaattatc 1547101 actataagct ggaatggttt gaatctgaac taaaaaaaca agatttaagc gaggcgttgt 1547161 aaaaatgaaa caagcaattt tatatgtcgg ccacggcagc cgggtcaaaa aagcgcagca 1547221 agaagccgca gcctttttgg aaggatgcaa ggcccacatc tctgtgccag tacaagaaat 1547281 cagcttttta gagcttcagg agccgacaat tgagacagga tttgaagcat gtgtgaagca 1547341 aggtgccact catatcgcag tggtgcctct gcttctttta acagctgcgc atgcaaaaca 1547401 tgatattccg gaagaaattg tccgtgttgc atctcgatat ccatcagtcc gtatttcata 1547461 cggaaagccg atcgggattg acgaagaagt agtcaaggct gtatatcacc gaatgaaaga 1547521 cataggtgtt ccgtatgaaa atgccagagt ggtgctcatc ggaaggggaa gttcagatcc 1547581 agacgtcaaa agagacgtaa ccggaattgc taatcttctt caggaaatgg ttccagtgaa 1547641 ggaagtcatt ccgtgctttt tgacagcatg cggccctaat tacaaagagg ttttttcaga 1547701 acttgaaaaa gatgacggca taacaacctt tatcgttcca tatttgcttt ttacgggtat 1547761 gctgatgaat gaaatcgaac gagaggttca gaaattaaaa gcccataatc cgaacgtcta 1547821 cctctcttcc tatatcggtt ttcatcctca tgtgaaaaac gcatttttga accgtgtgag 1547881 agaaactgcg gcaaattctg agggacaatt tgattttgat ggaggttcat atgcttccgc 1547941 tgcacattag cctggaaaag aagaaggttg tgattgcggg gggcggaagc atcgctctca 1548001 gaaggctgaa aacggtgatt tctgagggag ctgatataac gcttgtcagt ccggatgtgg 1548061 aaccggaaat caagcaaatg gcagaagagc ggcgtatcaa atgggaaaaa cggacaattg 1548121 aaaaagaaga ttatctcaat gctttcttca ttattgctgc gacggataat gcggcagtga 1548181 acaaagaaat tgcccaatcc gcttcgcctt ttcagcttgt caattgtgtc agtgacgctg 1548241 agcttggcaa tgtatatatg ccgaaaatcg taaaaagagg gcatgtcact gtgtctgttt 1548301 ctacaagcgg agccagtcca aagcacacga aagagcttgc tgaaaacgtg gataagctga 1548361 ttgacggcga ttttgttgct gaagtgaaca ggctttatca gatgagaaga aagaaataag 1548421 ccagagcata caaatgctct ggcttttctt tatgcggctc agcttttttt gagcttgatg 1548481 acagtatcag catcaggcgt gacaaagacg gtatgctggc tgtcataagt gacgaaaccg 1548541 ggtttcgcgc cgtttggttt tttgacatgc ctgatttttg tataatctac aggcactgaa 1548601 cttgaatctt tagcttttga aaaataagct gcaattgtcg cggcttccat gattgtttgc 1548661 tcatcaggtt cgctgcttct gatcacaacg tgggagccgg gaatgtcctt cgtgtgaagc 1548721 cagatatcgt ctctggccgc cactcttgtc gttaaatatt cattttgacg attgttctta 1548781 cccactaaaa ttgtcagccc tgaggtggat tcatatgttt ctaacaccgg attgtgcggt 1548841 ttttgctttt tctggccttt ttgctgctta gggcgtaaat atttgccctc aacaagctct 1548901 tccctgattt cgctgatatc ccggggagaa gcggacgaaa gctgctgaat cagctgatca 1548961 aaatattcga tctcttcctg tgccagcctg atttgctcct cgacaactgc gaccgaattt 1549021 ttcgctttct gatacttcgt gaaataggcc tgtgcgtttt cagaaggcgt tttgttcggg 1549081 tttaaaggaa tcgtgattgt cgggctttct tcatcataat aattgatgac ctcagcctgt 1549141 ttatcacctt ttttcagcat atataaatta gcggttaaaa gctctccgta aagctgaaat 1549201 tccttcgcgt tttccgaata ctccagggtt ttctctaatt ttttgatttt gttggcattc 1549261 ttcttccgtt cgttcacaac aaaacgctca agatcctgag cctgttgctt aacccggtct 1549321 cgttcagctt ttccgaaata aaaacggtcg agcagttcgc ttaatgaatc aaaacggcgc 1549381 gcttcgccct ttagatgagt cagctccagc agataaaaat attcctttcc gtttacagtc 1549441 gtaatgttgg gaatgaaacg gtgctctttc acttcggcaa acagtgccag caacgctttt 1549501 ggcagtgtga ctttgttggc aaggcctgct ctgtgaaccg cttctttggc gaaaagcgga 1549561 gacacgcctg aaaagtggtc gacaatttgt ttatcaagcc ttccttcttg aaagctgagg 1549621 tgacgcaaaa tatcatcttc tgacgcctca agaggcgata ttttgtcctg agcaggcgga 1549681 agcttataat cttggccggg cagtactgta cggtagctgt tcattgacgg tgataaatgc 1549741 ttaagtccgt cgataatcac attttctgct gcgtcagtca aaatgatatt gctgtggcgg 1549801 cccataattt ctacataaag ctttcgtacg gtttcatcgc caatttcgtt tcggcttttg 1549861 atatgaaaaa tcataatgcg gtctaagccc gcttgttcaa ttttctcaat gaatccgcct 1549921 tcgatatgct ttctcagcaa catgcaaaac attggcggtt cgcttggatt ttcataagct 1549981 tgtgccgtga tatgcacccg tgaatagctc ggatgtgccg ataataatag tttttggttt 1550041 tttcccttgg cacggatgtg gaaaatcaca tcgtgcttat atggctgatg gatttttgta 1550101 attcgtccgc ccattatttt ctcgttaagt tcgtgtgtca ttccgtatgt aaacatgcca 1550161 tcaaacgaca tatgcaatac accctctcat tcttcctgca ttcgataatt atagcatgaa 1550221 atgggacgag tcagaataag catgcttata gagtgatatc tctataagag agcaggggag 1550281 tggacgagcg gaatgaagtt tcatgaaatg ggacaaacag atttactaga ggcaaccaat 1550341 acgtccatga aacaaggatt aacagaaaaa gaggtaaaaa aacgccttga caagcatgga 1550401 ccaaacgagc tgcaagaagg gaaaaaaact tcagcgcttc tcttgttttt cgcgcagttc 1550461 aaagatttta tggtgcttgt gcttctggcg gcaacgttaa tctcaggatt tcttggtgaa 1550521 tatgtagatg cggttgcgat tattgcgatt gtgtttgtga atggcatact cggtttcttt 1550581 caagaaaggc gtgctgagca atctcttcag gctttaaaag agctttcaac accgcacgtc 1550641 atggcactca gggaaggaag ctggacaaag attccttcta aggaactggt gccgggtgat 1550701 attgtgaaat ttacgagcgg ggacagaatt ggcgcagacg ttcgaattgt tgaagcgaga 1550761 agccttgaaa tagaagaatc agcgctaacc ggggaatcaa tcccggttgt gaagcatgct 1550821 gataaattga aaaaaccgga tgtttcactc ggcgatatta ccaatatggc atttatgggt 1550881 acgattgtga cccgcggcag cggtgtcggg gttgtcgtcg ggacaggaat gaatacggct 1550941 atggggaaaa ttgccgacat gcttgaatcg gcagggacat tgtcaacccc gctgcaaaga 1551001 agactggagc agctcgggaa gattttgatt gttgttgcat tgcttctgac cgtacttgtc 1551061 gttgctgtcg gtgttattca gggtcatgat ctgtacagta tgtttttagc aggtgtctcg 1551121 ttagcggtag ccgctattcc ggaggggctg ccggcgattg tgacagtggc gctttcgctt 1551181 ggtgtacaga ggatgattaa acaaaaatcc attgttagaa agcttcctgc tgttgaaacg 1551241 cttgggtgtg cgtctatcat ttgctcagat aaaacaggga caatgaccca aaacaaaatg 1551301 acagtgacgc atgtctggtc cggagggaaa acatggagag tggcaggggc cggctatgaa 1551361 ccgaaaggaa gcttcacact aaacgaaaaa gagatcagtg tcaatgaaca taagccgctt 1551421 cagcagatgc ttctgttcgg agcgctttgt aacaactcca atattgagaa aagagacggc 1551481 gaatatgtgc ttgacggaga tccgacagag ggagcgctgc tcaccgcggc aagaaaaggc 1551541 ggtttttcaa aggagtttgt tgaatctaat tacagagtga ttgaagaatt tccgtttgat 1551601 tccgcacgga aaatgatgac tgtcatcgta gagaatcaag acagaaagcg ctatatcatt 1551661 acaaaaggtg cgccggatgt actcatgcag cgatcttccc gtatttatta tgatggctca 1551721 gcggctcttt tttcaaatga aagaaaagca gaaacagagg cggtattaag acatttggca 1551781 tcacaggcgc tcagaacgat agcggtcgcc tacaggccga taaaagcagg cgaaacaccg 1551841 tcaatggagc aggcggaaaa agatctgacc atgcttggcc tttcaggtat cattgatccc 1551901 ccgcggccgg aagtcagaca ggcgattaaa gaatgccgtg aagcgggaat taagaccgtc 1551961 atgattacag gtgatcatgt agaaaccgct aaagcgatag cgaaagactt gcgcctcctt 1552021 ccgaaaagcg gcaaaatcat ggacggcaag atgctgaatg aactttctca agaagagctt 1552081 tctcatgtgg tggaggatgt gtatgtattt gcccgcgttt cccctgaaca taaactaaaa 1552141 atcgtaaaag cctatcagga gaacgggcat attgtggcga tgacgggaga cggcgtcaat 1552201 gatgctcctg ccattaaaca ggctgatatc ggcgtctcta tgggcattac cgggacagat 1552261 gtggccaaag aagcatcatc tcttgttctc gtggatgata attttgcgac gattaaatca 1552321 gcgataaaag aaggcaggaa catctacgaa aatatcagga agtttatcag atacctgttg 1552381 gcgtctaacg tcggagaaat ccttgtcatg ctgtttgcga tgctgcttgc ccttccttta 1552441 ccgctggttc cgattcagat tttgtgggtc aacttggtga cggacggatt gccggcaatg 1552501 gcgctcggca tggatcagcc ggaaggagac gtcatgaagc gcaagccccg tcatccgaaa 1552561 gaaggggtat ttgcccgcaa gctaggatgg aaggtcgttt ccagaggatt tttaatcgga 1552621 gttgccacta ttttagcgtt tatcattgtg taccaccgca atccggaaaa cttggcttat 1552681 gcccagacga tcgcgtttgc cacattggtg ctcgctcagc ttattcacgt gtttgactgc 1552741 cgcagcgaaa cttctgtttt ctctagaaat ccgtttcaaa acctgtattt aatcggcgcg 1552801 gtattgtcat ccattttgct gatgcttgta gtaatctact atccgccgct tcagccgatt 1552861 ttccatactg tagccatcac gccgggggac tggatgctcg tcatcggtat gtccgccatc 1552921 cctacttttt tgctggcggg gtcactttta acaagaaaaa aataaattca tatgatataa 1552981 tcttaggggt aatagcgtgt ctattgccct tttattatga gaacagggaa gaattgggtg 1553041 ttttaaaatg atacgaagta tgacaggctt cggcagtgca agcaaaacac aagacgatct 1553101 ctctgtaagc gttgaactta aatctgtgaa ctacagattt aaagaagtga acgctcgttt 1553161 gccaaggcct ttgctatatt ttgaagataa gctgaaacag accattctgc agcatattca 1553221 gcgcggaaga attgagcttt tcgtatccgt tgacagcgat atgcttgttg agaaaaggct 1553281 tgaaattgat tggccgctgc tcgatgagtt tgtcgcagcc gcgagagata tgaagaagcg 1553341 gtatcaattg tctgcagagc ccgatgtaat ggatttcttt aagcttgatc atgtcgtcca 1553401 ggttcatgaa gaacagacgc aaaatgacaa gctggaggcg ttgatcatcg atgctgcaga 1553461 agaagcggta aaaggtctct gtgaaatgcg tgaaaaagag gggctgctct tagcgaaaga 1553521 ctgcctgatg catattgatc agcttgaaga gctggtgaga gaaactgaat tgctggctgc 1553581 agatgtcgta tctcgttacc gggaacggct gtatgccaga atcaaagaat ggactgaaga 1553641 cgtattagac gagagccggc ttgtaacaga atgcgctatt tttgcagacc gctctgatat 1553701 cactgaagag attacaaggc tgaagagcca cttcgcccag tttcgtgata tattagctag 1553761 tggcggagct gtcgggcgca aactcgactt tcttgttcag gagctcaatc gggaagcaaa 1553821 tacgatcggc tcaaaagcaa atgatcatca gatcacaaag cttgtcgttg aaatgaaaag 1553881 ttctattgaa aaaataaaag aacaagtgca aaatatagaa tagtgactgt gcgtattgtt 1553941 tacagacggt cttactaggc taaactagag acgtctattt tacaggggga acgtagaaga 1554001 tgacgattaa actgattaat atcggatttg gcaatatcat ctccgccaat cggatgattt 1554061 cgattgtcag cccggagtct gcgccaatca aacggatgat tcaggatgca agagaccgcg 1554121 gaatgctaat tgacgctaca tacggacgaa gaacccgtgc agttgtcgtc atggatagtg 1554181 atcacattat cttatctgcc gtccagcctg agacagttgc acacagactt tctgttaaag 1554241 aagaaattat ggatgaaggg caggggtaat tgccgcatga aagaaagagg gttattaatc 1554301 gttctctcag gtccctcagg agttggtaaa ggaacggttc gacaagcgat cttttcgcag 1554361 gaagacacaa aatttgaata ttcgatttca gtaaccacaa gaagtccaag agagggcgaa 1554421 gtgaacggag tcgattattt tttcaaaaca agagacgaat tcgagcaaat gattgcggac 1554481 aacaagctgc ttgaatgggc agagtatgtc ggcaattatt acggcacgcc agtcgattat 1554541 gttgaacaga cgcttcaaga tggaaaagac gtctttttag aaattgaagt tcaaggggct 1554601 cttcaagtga gaaatgcttt cccggaaggc ctgtttattt tccttgcgcc tccaagcctt 1554661 tctgaactga aaaacagaat cgtgacacga ggaacagaaa cagacgctct gattgaaaat 1554721 cgaatgaaag ccgcaaaagc tgagatcgaa atgatggatg cttatgacta tgtcgttgaa 1554781 aacgataatg tcgaaacggc ttgcgataaa atcaaagcaa tcgttcttgc tgaacatttg 1554841 aagcgtgaac gcgttgcacc aagatataag aaaatgctgg aggttgaata atcaatgtta 1554901 gatccgtcaa ttgattcttt aatgaataaa ttagattcaa aatatacgct ggtgactgtt 1554961 tctgcgagac gtgcccgtga aatgcaaatc aaaaaagacc aaatgattga acatacgatt 1555021 tcacacaaat atgtaggcaa agctttagaa gaaattgatg caggcctgct ttcgtttgaa 1555081 aaggaagacc gcgaatagta gcacaagtag caacctatat catgtaggtt gttatttttt 1555141 tccgtgcggt tttgtaaagt gcagaggggg agaattcatt gcttaacaat cgaaatgtgt 1555201 tactttgcgt gagtggaggc atcgctgttt ataaagcctg tgcgttaacg agcaagctgg 1555261 ttcaggcagg agcaaatgtc aaagtgatta tgactgaatc cgcttgccga ttcgtttcac 1555321 cgctgacatt tcaggcattg agccgccacg aagtctatac agatacattt aaagaacaaa 1555381 atccaagcgt catttctcat attgatgccg cagactgggc cgacttgatt atcgtagcgc 1555441 cggctacggc taatgtgatt ggaaaactgg caaacggcat cgctgatgat atgctgacga 1555501 caacattgtt ggcagcaacg gctcccgttt ggatcgcgcc ggcaatgaac gttcatatgt 1555561 atgaccaccc ggcagtcaaa cgaaacattt ctgttcttta tcaggacggt tattgtttta 1555621 ttgagccaag tgagggctat ttagcatgcg gttacgtagg aaaaggcaga ttggaagagc 1555681 cggaaaacat cgtaaagctg gccgaaaaac attttgctga agaaacatcc gctcctttag 1555741 aaggcaagca tgtggtcatt acagccggcc caacgcggga agcgattgat cctgtccggt 1555801 tttttaccaa taaatcgacg ggcaaaatgg gctacgcact ggcggaggct gctgttcagc 1555861 tcggcgcacg ggtaatctta atttctgggc ctgtttcact tgatcagcct aaaggccttg 1555921 ctgagtttat ccctgttcaa tcggctgcgg atatgcgcga agctgtgctc tctgtgtatg 1555981 acgcaagcga tatagtcatt aaaacagctg cggtagccga ttttacgccg aaaacagtat 1556041 ttgaccataa aatgaaaaaa caagacggcg gcatgacctt agaactgaaa agaacagtcg 1556101 atattttgaa agaattgggc gagaaaaaga aagagcagat tttggtcgga tttgccgccg 1556161 aaacacaaga cattgaacac tatgcacgta aaaagctcgc cgctaaaaac cttgatttga 1556221 ttgtggcaaa tgatgtgaaa gcaaatgggg ccggttttgg tgctgatacg aatatcgtga 1556281 caatcttttt caaagacggg cataaacgcg aactcccgat tatgtctaag ctcgatgttt 1556341 cttttgaaat ccttcaggag atcgcagccc tctcaaaaca aaccggagag cgctcatgaa 1556401 ttttgcagaa gtcatcgttg atgtcagcac caaaaatata gacaggcctt ttgattataa 1556461 aatcccagac catctgaagg gcatgatcaa aacggggatg cgggtcattg ttccgtttgg 1556521 cccccgtaag attcaagggt ttgtgacagc agtcaaagaa gcatctgacc tatcgggaaa 1556581 atctgtcaag gaagtagagg atttattaga tcttacacct gttctgacag aggagcttat 1556641 gattctgtca tcatggctgt cagacaaaac gctgtctttt aaaataacgg cgcttcaagc 1556701 aatgctgcct gccgccttaa aggcgaaata tgaaaaagaa ttaaaaattg cacacggagc 1556761 cgatcttccg ccgcaagtgg aacggctgtt ttctgaaaca aagacgctgc tgtattcaga 1556821 tatacccgat catgagacgc tgaaactgat tcaaaggcat gttcaaaaag gggacattga 1556881 cgtgacgtat aaagtcgcgc aaaaaaccaa taaaaaaatg gtcaggcata ttcaggcaaa 1556941 tgcgagtaaa gaagagcttg ctaagcaggc tgagggattg tcccgccaag cagcaaaaca 1557001 gcaggcgatt cttcactttc tcatctctga gccggaaggt gtgaaaattc ctgcggcgga 1557061 attgtgcaaa aaaacggaca cgagctctgc aaccatcaaa acccttatcc aaaaagggct 1557121 tttgaaggaa agctatgaag aggtttacag agatccctat caggacaaaa tgttcaaaaa 1557181 aacagagccc ctgccgctga cagacgaaca gagggctgcc ttcgagccca tacgcgagac 1557241 attggacagc gatgagcata aagtgttcct ccttcacggc gtgacaggaa gcggaaaaac 1557301 cgaaatttat ctgcaatcaa ttgaaaaagt actggcgaaa ggaaaagaag ccatcgtcct 1557361 cgtaccggaa atatcgctga cgccgcaaat ggtcaaccgc ttcaagggcc gcttcggctc 1557421 ccaggtggca gtcatgcaca gcggtttatc cacaggagaa aaatatgacg agtggcgtaa 1557481 aatccaccgg aaggaagtac ggcttgtcgt cggtgccaga tccgccattt ttgctccgtt 1557541 tgaaaatctc ggaatgataa tcatcgatga agagcacgag tcttcctata aacaggaaga 1557601 aatgccgcgc tatcatgcga aagaggtggc aatcaagcgg gctgagcatc acagctgccc 1557661 ggttgtatta gggagtgcta cgccgacatt agaatcatat gctagagcgc aaaagggcgt 1557721 atacgagctt ctttcactga agcaccgtgt taaccatcgg gtgatgcccg aggtttcgct 1557781 tgtcgatatg agagaggagc ttagaaacgg caatcgctcg atgttttcag ttgaattgat 1557841 ggaaaagctt gaagaaacga ttgccaaggg tgagcaggcg gtgctgtttt taaataagag 1557901 gggctactct tcctttgtga tgtgcaggga ttgcggctat gtcccgcaat gcccgcactg 1557961 cgacatttcc atgacgtatc atcgttacgg ccaaaggctg aaatgccatt attgcggaca 1558021 tgaagagcct gttccgcaca cttgtcctga atgcgcaagc gagcatatcc gctttttcgg 1558081 aacgggaaca cagcgagtgg aggaagagct gacaaaagtg ctgccaagtg cgagagtgat 1558141 tcggatggat gttgacacga catcacggaa aggcgcccat gaaaaattac tgtcagcttt 1558201 cggagaagga aaagcggata ttcttctcgg aacgcaaatg atcgcgaaag ggcttgattt 1558261 tccgaatgtc acgcttgtcg gagtgttaag tgctgataca acacttcata ttcctgattt 1558321 cagatcggct gaaaaaacat ttcagctgtt aacgcaagtc agcggccggg caggcaggca 1558381 tgaaaagccc ggccatgtca tcattcaaac gtatacaccg tctcattaca gtatccagct 1558441 gacgaaaaca cacgattatg aaacgttcta tcagcatgaa atggcgcaca ggagagagca 1558501 atcctatccg ccatactact atttggctct tgtgactgtt tctcatgagg aagtggcgaa 1558561 agcagcggtt acagctgaaa aaatcgctca ttttttgaaa gcaaactgcg gagctgacac 1558621 gaaaattctc ggaccaagcg cgtcgccgat agccaggatc aaagatagat atcgctatca 1558681 atgcgtgata aaatacaaac aggaaaccca gttatccgct ttattgaaga agatactgga 1558741 acattataaa cgcgaaattg aacaaaaaca tgtaatgatt tcaattgata tgaatcctta 1558801 tatgatgatg taagatctca cgtcttggag ggtaacaaat tggcagtaaa aaaggtcgtc 1558861 acacatcctg cggaggtttt ggaaacacct gcggaaaccg tgactgtttt tgataaaaag 1558921 ctaaaaaaac tgcttgatga tatgtacgac accatgcttg aaatggatgg tgtcggactg 1558981 gcagcgccgc aaatcggcat tttaaaaaga gcggccgtcg tagaaatcgg ggatgacaga 1559041 gggagaattg atctcgttaa tcctgaaatt ttagaaaaaa gcggcgagca aaccggaatt 1559101 gaaggatgct tgagctttcc taacgtctat ggtgatgtca cacgtgccga ttatgtcaaa 1559161 gtgcgtgcgt ttaaccgtca gggaaaaccg ttcattctgg aagcgcgagg ctttttagca 1559221 agagccgtgc agcatgaaat ggaccactta gacggtgtgc tgtttacatc taaaataagt 1559281 aaatactata cagaagatga actagcggat atggaaggat gatttgatga cgagaatcgt 1559341 atttatggga acgccggatt tttcagttcc tgttttaaga accctgatag aggacggata 1559401 tgaagtagtg ggggtcgtca cacagccgga ccgtccgaag ggcagaaaaa aagtactgac 1559461 acctcctccg gtaaaggaag aggcattgcg ccacggcatc ccggttcttc agccggaaaa 1559521 agtcagattg acagaagaaa ttgaaaaagt gctggcatta aagcctgacc tgattgtaac 1559581 ggcggcattc ggacaaattt tgcctaaaga gcttctcgac agtccaaaat acggctgcat 1559641 taacgttcac gcatcccttt tgccggaact gcgcggcggt gctccgatcc attattccat 1559701 tctgcaggga aagaagaaaa ccgggattac cattatgtat atggtagaaa aattggatgc 1559761 gggcgatatg atctcaaaag tggaagtgga cattgaagaa accgacaatg tcggaacact 1559821 gcacgataaa ttaagcgttg ctggcgcgaa gctattgtct gaaacggttc caaacgttat 1559881 tgccggcagc atatcacctg aaaagcagga tgaagagaaa gcgacgtacg cgcctaacat 1559941 taaaagagag caagagctgc tcgactggtc cagaacgggc gaagagcttt acaaccagat 1560001 ccgcggctta aatccatggc ctgttgctta tacgactcta aacggacaaa acttgaaaat 1560061 atgggcgtcg aaaaaaatag cggcaccaac aacagctgag cccggcacag tcgttgcagt 1560121 tgaaaaggaa ggaattatcg ttgccacagg taacgagacg gctctgttat taaccgaact 1560181 ccagccggca ggcaaaaaac gaatgaaagg cgaagacttt gtgcgaggcg ctcatgttga 1560241 agccggtgat gtgttaggag taaacaatga aaaaaactag tgttcgtgac atcgcccttg 1560301 aggcgctgat caaattagaa caaaaccagg catacagcaa cctgctgctg aaatcggtca 1560361 ttaaatcaaa tgaactgagt gatcagaaca gagggctttt gactgaactt gtctatggta 1560421 cattacaaaa taagatcgcg cttgattata tgcttaaacc gtttatcaat aagcctcaaa 1560481 aggtaaagcc gtgggtgatt cagcttcttc gcctatcctt atatcaaatg gagtatttgg 1560541 agaagattcc agacagggca gccattcatg aagcggttga gattgctaaa atccgcggac 1560601 acaaaggcat tgcttcattt gtcaacggcg tgctccgttc tattcagcgc gaaggtgttc 1560661 catcctttga cgcgatcgaa gatcctgtcc gccggctggc gacagaaaca agccatccgg 1560721 aatggcttgt gaaagagtgg gcggatgcgt atggatttga agctgcggaa aagatttgcc 1560781 gcatccatct cattccgccg aaacagacgc tgcgtgtcaa tcaaatgaaa gcagacagag 1560841 ctgagctgct tgaccaaatg gctgctgagg gaatcgaagt tgaaaaaggc gacctcgctg 1560901 aagatgctgt gaagctctta aagggaacaa ttgccggaac tcatttcttc caaaacggcg 1560961 aagtttctat ccaggatgag agctccatgc tcgtcgcccg cgcccttgat cctaagtcag 1561021 atgaaacagt gcttgacgcg tgtgcggcgc ctggcggaaa gtcggctcat atcgcagaat 1561081 taatgaagaa caaggggagc gttacgtcgc ttgatcttca caaacataaa gtgaagctga 1561141 tcaaagaagc ggcagatcgg cttggcctga caatcattca tgcggaaaca atggatgcta 1561201 gaaaagcggg ggaaacgttt gaaaacgaac agtttgaccg aatattggtc gatgccccgt 1561261 gctcaggttt cggtgttatc agaagaaagc cggacatgaa atacacgaaa aaacctgacg 1561321 acagcgcccg tctagctgaa atccagctgt cgatcttgag ggaaatcgca ccattagtaa 1561381 aaaaaggtgg cactcttgtc tacagtacgt gtacaatgga ccggacagaa aatgatgaag 1561441 taatacatgc gtttatacaa gaacatcctg attttgaacc cgatttgtct cttgaaaagc 1561501 ggctgcctga aaaggtgaga ccctttgttc gggatggaag gcttcaaatc cttcctcatt 1561561 atttcggaac agatggtttc tttatttgca gcatgagaaa gaagggataa gcaatggcag 1561621 aacttaataa aacaaaagta agaaaagaat tgcggacaga gcgtccgtct atttattctt 1561681 ttgaattaga tgaaatcaaa caatggctga cagacaatgg agagaaaccg ttccgtgcag 1561741 cccagatctt tgaatggcta tatgaaaaac gcgtatcttc ttttgaagat atgacaaacc 1561801 tctcaaagga tctgcgtgag aaattaaaca ctcgctttgt gttaacaacg ctgaaaacgg 1561861 ctgttaaaca aacctctcaa gacggtacga tgaagttttt gtttgagctt catgacggtt 1561921 ataccatcga aaccgtttta atgagacacg agtatggcaa ttctgtatgt gtaacgacac 1561981 aagtcggctg ccgtattggc tgcacattct gcgcgtcaac gcttggaggc ttaaaacgaa 1562041 accttgaagc aggggaaatt gtcgctcaag tagtcaaagt gcaaaaagct cttgatgaaa 1562101 cggatgaacg cgtcagctct gtcgtgatca tgggaatcgg cgaacctttt gataacttta 1562161 acgaaatgct cgctttcttg aaaatcatta accatgacaa gggcctgaat atcggtgctc 1562221 gccatattac ggtctctacg agtggaatca tcccgaaaat ttacgaattt gctgatcagc 1562281 aaatgcagat taactttgca atttctctgc acgcgccgaa cacagaaatc agaagccgtt 1562341 tgatgccgat taacagagca tataaactgc ctgatctaat ggaagccgtt aaatattata 1562401 ttaataaaac aggacgccgt atcagctttg aatacgggct gttcggaggc gtaaacgacc 1562461 aggtggaaca cgccgaagag cttgccgact tgctggaagg agtcaaatgc cacgtgaact 1562521 tgattccggt aaactacgtg cctgaacggg actatgtgcg cacaccgcgt gatcagattt 1562581 ttgcttttga aaaaacgctg aaatcccgcg gagtaaatgt cacaatccga agagagcaag 1562641 gacatgacat tgacgcagcc tgcggtcagc ttcgcgcgaa ggagcgtcaa gacgagacga 1562701 ggtgatgagg gttgttaaca gccttaaaaa cagatacagg aaaaatccgc cagcataatg 1562761 aagatgatgc ggggatattc aaggggaaag atgaatttat attagcggtt gtcgctgatg 1562821 gcatgggcgg ccatcttgct ggagatgttg cgagcaagat ggctgtgaaa gccatggggg 1562881 agaaatggaa tgaagcagag acgattccaa ctgcgccctc ggaatgtgaa aaatggctca 1562941 ttgaacagat tctatcggta aacagcaaaa tatacgatca cgctcaagcc cacgaagaat 1563001 gccaaggcat ggggacgacg attgtatgtg cactttttac ggggaaaacg gtttctgttg 1563061 cccatatcgg agacagcaga tgctatttgc ttcaggacga tgatttcgtt caagtgacag 1563121 aagaccattc gcttgtaaat gaactggttc gcactggaga gatttccaga gaagacgctg 1563181 aacatcatcc gcgaaaaaat gtgttgacga aggcgcttgg aacagaccag ttagtcagta 1563241 ttgacacccg ttcctttgat atagaacccg gagacaaact gcttctatgt tctgacggac 1563301 tgacaaataa agtggaaggc actgagttaa aagacatcct gcaaagcgat tcagctcctc 1563361 aggaaaaagt aaacctgctt gtggacaaag ccaatcagaa tggcggagaa gacaacatta 1563421 cagcagtttt gcttgagctt gctttacaag ttgaagaggg tgaagatcag tgctaatcgg 1563481 caagcggatc agcgggcgtt accaaattct ccgcgtcata ggcggcgggg gaatggccaa 1563541 cgtgtattta gctgaggata tcattctaga ccgtgaagtc gcaattaaaa tcctgcggtt 1563601 tgactatgca aatgacaatg aatttatcag acgtttccgc agagaagccc aatccgcatc 1563661 aagcctcgat cacccgaata ttgtcagcat ttatgatttg ggcgaggaag atgatattta 1563721 ttatattgtc atggaatacg ttgaaggcat gacgcttaaa gaatacataa cagcaaatgg 1563781 gccgcttcac cctaaagaag cgctgaacat catggagcaa attgtctcag ccatcgctca 1563841 tgcccatcaa aaccagattg ttcacagaga catcaagccg cataacattt tgattgatca 1563901 tatgggaaat atcaaagtaa cggattttgg aattgcgacg gcactaagtt cgaccacaat 1563961 cacccatacc aattcagttc tgggctcggt ccattactta tcacctgaac aggcccgggg 1564021 cggcttagcc acaaaaaaat cggatattta tgcgcttgga atcgttctat ttgagctttt 1564081 aaccggccgt attccgtttg atggagagtc agcagtcagc atcgccttga agcatcttca 1564141 agcggaaact ccttcggcaa aaaggtggaa tccatcggtc ccccaaagcg ttgaaaacat 1564201 catactcaag gcaactgcca aagatccttt tcatcgctac gaaacggctg aagacatgga 1564261 agcagacata aaaacagctt ttgatgccga cagactcaat gaaaagagat ttacgattca 1564321 agaagatgaa gaaatgacaa aagcgatacc tatcattaaa gatgaagaac ttgctaaagc 1564381 tgctggcgaa aaagaagctg aagtgacaac cgcacaagaa aacaaaacaa agaagaacgg 1564441 caaaagaaaa aagtggccgt gggttttgct cacgatatgc ctcgttttta tcacagctgg 1564501 aattcttgct gtcactgttt ttccgtcgct tttcatgcct aaggatgtca aaatacctga 1564561 tgtctccgga atggaatacg aaaaagccgc agggctcttg gaaaaagaag gtttacaggt 1564621 tgattccgag gtgttggaaa tctcagatga aaaaattgaa gagggcctga tggtaaaaac 1564681 ggatcctaaa gcggatacca cagtcaaaga aggcgccacg gtcacccttt ataagagcac 1564741 cggaaaagca aaaacggaga tcggtgatgt gacaggccaa acggtcgacc aagcaaaaaa 1564801 agcgttgaag gaccaagggt ttaatcatgt aacagtaaat gaagtgaatg acgagaaaaa 1564861 tgcgggcact gtcattgacc aaaatccttc agcagggact gagctggtcc cgagtgaaga 1564921 tcaagtcaaa cttacagtca gtatcggacc cgaagacatt acgcttagag acttgaaaac 1564981 ctacagtaaa gaagcagcgt ctggatatct ggaagacaac ggattgaagc ttgtagaaaa 1565041 agaagcatac tcagatgatg ttccagaagg acaggttgtc aaacaaaaac cagcagcagg 1565101 tacggcagta aagccgggaa acgaagttga agtgacattc tctctcggac cagagaaaaa 1565161 acctgcgaaa acagtgaaag aaaaggtcaa gatcccctac gaaccagaaa atgaagggga 1565221 cgagcttcaa gtgcaaatcg cggttgacga tgcggatcac agcatctctg acacttacga 1565281 agaatttaag ataaaagagc cgactgaacg aacgatcgaa ctaaagattg aaccaggcca 1565341 aaaagggtac tatcaagtaa tggtaaacaa taaagttgtc agctacaaaa ccattgagta 1565401 tccgaaagat gaataacaag gagggaaaat atgcctgagg gcaaaattat taaggcgcta 1565461 agcggctttt actatgtact ggatgaatca gaggattcag ataaagtaat acaatgcaga 1565521 ggaagaggca ttttcagaaa aaacaaaatt acccctcttg tcggtgatta cgttgtgtat 1565581 caagctgaaa atgacaaaga aggatatcta atggaaatta aagaaagaac caacgagctt 1565641 atcaggccgc caatttgcaa cgttgatcaa gcggtccttg ttttctcagc ggttcagcct 1565701 tctttcagca cggcattgct cgaccgcttc ctggttctcg ttgaggccaa tgatattcag 1565761 ccgattatat gcattactaa aatggatctg attgaagatc aagatacaga agatacgata 1565821 caagcctatg cagaagacta tcggaatatt ggttatgacg tataccttac ctcctctaag 1565881 gaccaagata gtttagcgga catcatcccg cattttcagg ataaaacaac ggtatttgcc 1565941 ggtcagtccg gtgttgggaa atcctcgctt ctcaacgcga tcagtccgga gctcggatta 1566001 agaacaaacg agatttccga gcatttgggc cgcgggaaac acacaacccg ccacgtggag 1566061 ctgattcaca cgtccggagg tttggttgca gatacaccgg gattcagctc gcttgaattt 1566121 acagacattg aggaagaaga gctgggctat accttccctg atatcagaga aaaaagctct 1566181 tcatgcaaat ttagaggctg tttacatctg aaagagccga aatgtgcggt gaaacaagct 1566241 gttgaagacg gggaattaaa gcagtatcgc tatgaccatt atgttgaatt tatgacggag 1566301 attaaagaca gaaagccgag gtattagcat aatgataaag gttgcaccat ctattctttc 1566361 cgctgatttt gccgctttag gcaatgagat taaagatgta gaaaaaggcg gagccgattg 1566421 tattcatatt gatgttatgg acggccattt tgtcccgaat atcacaatcg gtccgctgat 1566481 tgtagaagcg gtccggccgg taacggatct gccgcttgat gtccatttaa tgatagaaga 1566541 gccggatcgt tatatcccgg cttttgcgaa agcaggcgca gatatcctgt ctgtgcatgc 1566601 tgaggcatgt ccgcacctgc accgtaccat ccagctcatt aaagagcaag gagtgaaggc 1566661 cggagtagtt ctaaacccgc atacccctgt acaagtcatc gaacatgttt tcgacgatct 1566721 tgatcttgtt cttttaatga cggtgaaccc gggcttcggc gggcagaaat ttattcattc 1566781 agtccttcct aaaataaaag aggttaagcg aatggcggat gaaaaaggaa aaaaagatct 1566841 gttaattgaa gtagacggcg gcgtcaacaa agaaaccgct ccgctcgtca ttgaagcggg 1566901 cgcaaattta ctcgttgccg gttcagctgt ttatggccag tctgaccgca aaaaagcaat 1566961 ttctgaaatc agaggaagta aataagcagc tttagaaaag agctgggcat acaatagcct 1567021 aagctctttt tcctgtatgc agagaaagga atcagagatg aaaacaatta atatcgttgc 1567081 gggaggcccg aaaaatctca ttcccgatct aaccggctat acggatgaac acacgctttg 1567141 gatcggtgtt gacaaaggca ccgtcactct cttagatgcc gggatcattc ctgttgaagc 1567201 cttcggagat tttgacagca taacggagca agaacgccgg cgaatagaaa aagccgctcc 1567261 cgcccttcat gtgtatcaag cagaaaaaga tcaaacagat ttagacctcg cccttgattg 1567321 ggcgctggaa aagcagccgg atattattca gattttcggc attacaggcg gcagagctga 1567381 tcatttttta ggaaacattc agcttctgta taaaggtgta aaaacgaaca taaaaattag 1567441 gctgatagac aaacaaaatc atattcaaat gttccctcct ggtgaatatg atattgagaa 1567501 ggatgaaaat aagcgatata tctccttcat accgttttcc gaagacatac atgagctgac 1567561 cctgaccggt tttaaatatc ctctaaataa ttgtcatatt acgctcggtt caacactatg 1567621 tattagtaac gaactcattc attcacgagg tactttttcg tttgcaaaag gcatattaat 1567681 aatgataaga agcacggatt aagcatgtgc tttcattcaa ttgctgaaaa caatgaacaa 1567741 ggcggttacg ggacgttata ggaggggaca aaaatgaaat tttacaccat taaattgccg 1567801 aagtttttag gaggaattgt ccgggcgatg ctgggctcat ttagaaaaga ttaatgccca 1567861 ggggttcaaa gccctctttc accacataaa aacgcctgcc acatatcggg gcaggcgttc 1567921 attttgttat acacgctcaa ctttaccgga tttcaaagct cgagcagata catatacttt 1567981 tttaggtttt ccgttcacaa ggatacgaac cttttgaaga ttcgcgcccc aagtgcgctt 1568041 agaagcgttc attgcgtgag aacggttatt cccagctgtt gtttttttac ctgtgataac 1568101 gcatttacgt gccatttgtt tccctcctca cttgcacaaa acatctactt tttaacattc 1568161 atataatctt agatgctttc gatatggata ctttaaataa tttaccacag ctaaaaaacg 1568221 tttgcaacta ttgtttcatc atctttcaag aaaattcact tgacatcttg cggaaacagc 1568281 agcgctatag tatatgtaga ggtacggcca gcgattattg cctggtcttt tcataatgga 1568341 aaccatatag tagaatagct gtaactctat gcattcgaag gaggaactag tgtgtccatt 1568401 gaattaagaa cgaagtacgg acagattgat atatctaatg aagtcatcgc gatggttgca 1568461 ggaggcgcgg cggttgactg ttacggcatt gtcggcatgg cctctaaaaa ccagattaaa 1568521 gacggactga ctgaaatcct tcggaaagag aatttcagca ggggtgtcca agttcgccaa 1568581 gaaggagaac agatacatat cgacatgtat atcattgtca gctacggcac gaaaatttct 1568641 gaagtggcac ataatgtcca aacaaaagta aagtacacag taaatcaaac catcggactg 1568701 gcagtggatt ctgtcaatat ttatgtccaa ggcgtacgag tgacgaaccc gtagttagga 1568761 ggagtaggat tgtctatcag aacattagac ggcagaacct ttgccgagat gattcttgcg 1568821 ggagcgcaga atctgtctca aaacgccagt gcagttgatg cactgaacgt gttcccggtg 1568881 ccggacggtg atacgggaac aaatatgaac ctgtcgatga cttccggagc aagagaagtt 1568941 gaacaaatgg atacggatga tatcgggaag gtgggctccg cgttatctaa agggctgctc 1569001 atgggagcac gcggaaattc aggagttatc ctatcccaat tgttccgcgg atttagcaaa 1569061 aacattgaaa cgaaaaaaga aattaatgca cttgagtttg ccgctgcgct gcaagcaggt 1569121 gtagacatgg cgtataaagc tgtcatgaaa cctgtagagg gcaccatttt aacagttgca 1569181 aaagacgctg caaaaaaagc aatgatctta gcagaaaaag aaaccgatat cactgcgctg 1569241 atgactgcag tgacagaaga agcagaggcg tctttaaacc gcacccctga attgctacct 1569301 gtcctaaagg aagtaggagt tgtcgatagc gggggcaaag gcctgctctg tgtgtatgaa 1569361 ggtttccttg cttcattaaa aggtgaaact gtacctcaga aagcagttct tccgtcactt 1569421 gacgacatgg tcagcgcaga gcatcacaag agcgcgcaaa gcatgatgaa taccgaagat 1569481 attgaatttg gattctgtac cgaagtgatg gttaggcttg atcagacaaa aagagagttc 1569541 gacgaaggca cgttcaggca agacctcagc cagttcggag attctctgct tgtgattgcg 1569601 gatgaatcgc tggcgaaggt tcatattcat gctgaagagc cgggaaacgt gttaaactac 1569661 gcccagcatt acggtgaatt gatcaaaata aaaatagaaa atatgagaga acagcatacc 1569721 tctatcatca gtcaagaaag caaacctgca gacaacgaaa caccgccggc aaaacagccg 1569781 tatggcattg tgactgtagc gatgggagaa ggaattgcag acctatttaa aagcattggc 1569841 gcttctgttg tgattgaagg cggccagacc atgaacccaa gcactgagga tattgttgat 1569901 gccgtgaagt ctgtaaatgc agatacggta tttatcctgc ctaacaactc caacattatc 1569961 atggctgcta accaagcggc cagcgtagtg gatgaacagg tttttgtcat tcctgctaaa 1570021 acggttccgc aagggatgtc agctctgctg gcttttaacc cggatcaaga agctgaagcg 1570081 aacgaggcca atatgctaag cgccattcag caagtaaaaa gcggacaggt gacgttctca 1570141 gtcagagata ctcatattga cggtaaagac attaaaaaag gcgactttat gggcattctg 1570201 aatggaacga ttatcggcac ttctgaaaat cagctgtcag ccgcgaaaat gctgctgtca 1570261 gaaatgatcg gagaagatga tgaaatcgtg accattctat atggtgagga tgcgtctcag 1570321 gaagaagctg agcagcttga agcgtttctc agtgaaaagt acgaggagat tgaggttgag 1570381 atccacaatg ggaaacagcc tctgtattcg tatatagttt cagcagaata gaagggcaat 1570441 ttgcccttct attcttatgt ctgcttttaa gtgcggcagc gctgtaacgc gcccgcttgc 1570501 cattttatat ctgatcaatt agtctagaag caaagcgcta ataagctctg gttcataagg 1570561 aggaatagca tgaaatacag aagcgttttt gatattatcg gcccggttat gatcggtccg 1570621 tccagctctc atacagcggg agctgctaga atcgggagag tggccagaag tttatttggc 1570681 agagagcctg agcgcatcat tgtatctttt tacggctcgt ttgcggaaac gtataagggc 1570741 cacggcacag atgtcgcgat tatcggcgga ttgcttgatt ttgatacatt cgatgaacgg 1570801 attaaaaccg ctatacaaat tgcagaagct aaaggaattg atatagagtt tcgggtagaa 1570861 gacgcagtcc cggtccaccc gaacacagca aaaatcacca tttctgatga aaagggtgag 1570921 ctggaactga cgggtatttc gattggcgga ggaaagattg aaatcacaga attgaatggt 1570981 tttgagctcc ggctgtcagg aaatcatccg gccatattag ttgttcataa tgacaagttt 1571041 ggcacaattg ccggtgttgc caatgttctg gcgaaatttt caatcaacgt aggacatatg 1571101 gaagtagccc ggaaagatat cggccagctt gcgctgatga caatagaggt cgatcaaaat 1571161 attgacgacc acattctcga cgagctgtcg aagctgccga atattattca agtgacaaag 1571221 attgctgact agcgaaaagg gtcaggagga gccagttatg tttcgtaatg taaaagaatt 1571281 aattgagatt actaaagaaa aacaaatatt gatctctgat gtgatgatag ctcaagagat 1571341 ggaagtaaca gaaaaaacaa aagaggacat ttttcagcag atggatcata acctgtctgt 1571401 tatggaagcg gcggttcaga aaggactcga gggagttacg agccaaacgg gcttaacagg 1571461 cggagatgcc gttaaattgc aggcctatat tcgatcagga aaaagcctgt ctggcccgct 1571521 gattttagat gctgtatcga aagccgttgc aacaaatgaa gtaaatgcag ccatgggaac 1571581 catctgtgcg acaccgactg caggttctgc cggtgtggtg cccggtacgt tatttgctgt 1571641 aaaagaaaag ctgaatccaa caagagaaca aatgatccgc tttttgttta cagccggggc 1571701 tttcggattt gtcgtggcca ataacgcaag catttccggc gccgccggag gatgtcaggc 1571761 agaggttgga tcagcttcag gcatggcggc tgcggctatt gttgaaatgg caggaggaac 1571821 acccgaacaa agcgcggaag ccatggccat tacattaaaa aatatgctag gcctcgtgtg 1571881 cgaccctgtt gcagggcttg ttgaggtgcc ttgcgtgaaa cggaatgcga tgggcgcgtc 1571941 aaatgcgatg attgctgctg atatggcatt ggcgggcatt acaagccgta ttccatgtga 1572001 tgaggttatc gatgccatgt ataaaatagg ccaaacgatg ccaactgcac ttagagaaac 1572061 aggccagggc ggtttagcgg caacaccgac aggaagagaa ttagagaaaa aaattttcgg 1572121 aggagcgcta ggttcacgtg aaacaacatc agcaaactag tatagctaac attaagggta 1572181 ttgggccgga aacagaaaaa acattgaatg aactcggtat ttatgacatt tctgatcttc 1572241 tgaattattt cccttatcgc tatgatgact acgagctgag ggatttagaa gaagtaaagc 1572301 atgatgaaag agtcacagtc gaagggaagg ttcattcaga gccttctctt acctattacg 1572361 gaaaaaaacg aaacaggctg acattcaggc ttctggtcgg ccactattta atcacagccg 1572421 tatgttttaa ccggccttat ttgaagaaga agctttcgct cggctctgtg gtgacggttt 1572481 caggtaaatg ggacaagcac cgccaaacca tctctgttca ggagttgaaa aacgggccgc 1572541 atcaagaaga caaaagcatt gaaccagtgt attctgtgaa agaaaatgtt accgtcaaaa 1572601 tgatgaggcg ctttattcag caggcgctga cccaatatgc agactcactt cctgatcctc 1572661 ttccggaaaa gctaagaaaa agctataaac tgcctgacta ttatcaagcg ttaaaagcaa 1572721 tgcaccagcc tgaaacaagg gaagcattaa agcttgccag acggcggttt gtttatgaag 1572781 aatttttgtt gtttcagttg aaaatgcagg cgttccgaaa ggcggaaaga gagcagacac 1572841 aagggatacg gcagcgtttt tcaaacgaag aactcatgag atttatcaaa agcctcccgt 1572901 ttcccctcac aaacgcccag tcacgcgttc ttcgcgaaat aacagcagac atgtcttctc 1572961 catacagaat gaaccgtctt cttcaagggg acgttggatc aggaaaaacg gcagtcgccg 1573021 ccattgcact gtatgccgcg atcctatccg gataccaagg agcgctcatg gtgccgacag 1573081 aaattctggc cgagcagcat gctgattcgc tcgtttcgct atttgaaaaa tgggacgtca 1573141 gcgttgctct tttgacaagc tctgttaaag gaaagcggcg aaaagaactg cttgagcgtc 1573201 ttgcggcggg tgagattgat attcttgtag gaacccatgc tttaatccaa gacgaggtgg 1573261 agtttaaggc gttgagtctc gttattactg atgaacagca cagatttgga gttgagcagc 1573321 gcaaaaagct tcggaacaaa gggcaggatc ccgatgttct ctttatgaca gccactccaa 1573381 tcccaagaac attagcgatc acagtattcg gtgaaatgga tgtatctgtc attgatgaga 1573441 tgccggctgg acgaaagcga attgaaacct attgggtaaa acatgacatg cttgatcgta 1573501 ttttggcatt tgtcgaaaaa gaattaaagc aaggcaggca ggcttatatc atctgtccgc 1573561 tgattgaaga atcagataag cttgatgtgc aaaacgccat tgacgtgtac aatatgcttt 1573621 ctgatatttt tcggggaaaa tggaatgtcg gccttatgca tggaaagctg cattccgatg 1573681 aaaaagatca ggtcatgaga gaattcagcg caaatcactg tcaaattctc gtatcaacca 1573741 ctgttgtgga ggttggcgta aatgttccga atgcaacaat tatggtgatt tatgacgccg 1573801 accgtttcgg actatcacag cttcaccagc tgcgcggccg tgttggacgg ggtgagcatc 1573861 aatctttctg tattctgatg gctgatccaa aatcagaaac agggaaagaa cggatgagga 1573921 tcatgtcgga gaccaatgac ggtttcgagc tgtctgaaaa ggatctggaa ctgagaggtc 1573981 ccggtgattt cttcgggaaa aaacaaagcg gaatgccgga atttaaagtg gcggacatgg 1574041 ttcatgatta cagagcgctt gaaacggcaa ggcaggatgc tgcgaatctt gtggcttctg 1574101 acgcgttctg gaaggagccg gaatacgctg tgttaagaga tgaattgctg aagagcggag 1574161 taatggacgg ggaaaaatta agctgagtat cagaagtttt tggtgttcag ccagaaacaa 1574221 tcgttgcatt ccaatctatg aaattatata ctactattag tacctagtct taattgtccg 1574281 gatggtgttt agatatgaga agaaataaga gagaacgcca ggaattactt cagcagacga 1574341 ttcaagcaac cccctttatt acagatgaag aactagcggg taaattcggg gtgagcatcc 1574401 agacgatacg tttggaccgc ttagagcttt ccatacctga actgagagaa agaattaaga 1574461 acgtggcaga gaaaacactt gaggacgaag tgaagtccct gtcacttgat gaagttatcg 1574521 gagaaattat tgaccttgag ctggatgatc aggcgatatc cattttagaa ataaaacagg 1574581 agcacgtgtt cagccggaat cagattgcga gaggacacca tttatttgca caggcgaatt 1574641 ctttggccgt tgcagtcatt gatgacgagc tggcgctgac tgcaagtgca gacatccgct 1574701 ttacaagaca ggtaaagcag ggtgaacgtg tcgtagcaaa agcgaaagtg acggctgtcg 1574761 aaaaagaaaa aggaagaacg gttgtcgaag tgaacagcta cgttggcgaa gaaattgttt 1574821 tttctggacg ctttgacatg tatcgttcaa aacattcata aaggtggagc atgcatgaga 1574881 atagctgtag atgcaatggg aggagaccac gctcccaaag ctgttattga cggagttata 1574941 aaaggtatag aggcatttga tgatctccat atcacacttg tcggtgacaa aacaacgata 1575001 gaatcacatt taacaactac atcagatcgc atcacggtgc tgcacgcaga tgaagtgatt 1575061 gagcctacgg atgaaccggt ccgtgccgtg cgaagaaaaa agaactcatc tatggttctt 1575121 atggcgcagg aggttgcgga aaacagagct gacgcctgca tttcagcggg aaataccggt 1575181 gcattaatga cagccggtct ctttattgtc gggagaatta aaggaattga ccgtccggcg 1575241 cttgctccga cacttccgac tgtttcggga gacggatttc ttctccttga tgtcggcgcc 1575301 aatgtcgatg ccaaaccgga gcacctcgtt caatatgcca tcatgggttc tgtttattct 1575361 cagcaagtgc gcggtgtcac ttcaccgaga gtcggacttt taaatgtcgg aacagaagat 1575421 aaaaaaggaa acgaactgac gaagcagacg tttcaaattt taaaagaaac agcaaacatc 1575481 aattttatcg gaaacgtgga agcgcgagac cttttagatg atgtggcgga tgttgtagta 1575541 acagacggct ttaccgggaa tgttacactc aaaacgctgg aaggctctgc gttgtcaatt 1575601 tttaaaatga tgagagacgt aatgacgtct actttgacat ccaagcttgc agcagctgtg 1575661 ctgaaaccaa aattgaaaga aatgaaaatg aaaatggagt attcgaatta tggcggagca 1575721 agtctttttg gcttaaaagc gcctgtgatc aaggcgcacg gctcttcaga ttcaaatgct 1575781 gtattccatg cgattcggca agcaagagag atggtcagcc aaaatgtggc tgcgctcatt 1575841 caggaagaag tgaaagaaga aaaaacagat gagtagtctg gaggttttta catcatgagt 1575901 aagattgcat ttttattccc gggtcaggga tcacaattta tcggcatggg aaaagagctt 1575961 tatgagcagg tgcctgctgc aaagcgtctg tttgatgaag ccgatgaaac gttggaaaca 1576021 aaactcagct cgcttatttt tgagggggat gctgaagaat taacacttac atacaatgcg 1576081 cagcctgctt tgcttacgac aagcatcgct gttcttgaga aatttaaaga atctggcatt 1576141 acacctgatt tcacagcagg acacagcctt ggtgaatatt ctgcactggt tgcggctggc 1576201 gctctgtctt tcaaagatgc tgtttatact gtcagaaagc gcggagagtt tatgaatgaa 1576261 gcggtgccgg ctggcgaagg agcaatggct gcgattctcg gcatggatgc tgaagcatta 1576321 aagcaagtaa ccgataaagt cacagaggaa ggcaaccttg tacagcttgc gaatctcaac 1576381 tgtcctggcc aaatcgtcat ttccggaaca gctaaagggg ttgagcttgc atctgaactg 1576441 gcaaaagaga acggcgcaaa acgcgcaatt ccgcttgaag taagcggtcc gttccattct 1576501 gaactgatga aaccggctgc tgaaaagctg aaagaggtat tggacgcctg tgacataaaa 1576561 gacgctgacg ttccggtcat ctcaaatgtt tctgctgacg tgatgactga aaaagcagat 1576621 atcaaagaaa aacttattga gcagctttac tctccggttc gttttgagga aagcattaac 1576681 aagctgatcg cagagggtgt tacgactttt attgaaatcg gtcccggaaa agtgctttca 1576741 ggccttgtga aaaaagtgaa tagacggtta aaaacaattg ctgtatcaga tccggaaacg 1576801 atcgagctgg caattcaaac gcttaaggag gagaatgata atgcttaatg ataaaacggc 1576861 tattgtcact ggcgcatccc gcggaatcgg ccgctcaatc gcccttgatc tggcaaaaag 1576921 cggagcaaat gttgtcgtga actactccgg caatgaagcg aaagcaaatg aagtggtaga 1576981 tgaaatcaaa tcaatgggca gaaaagcaat tgctgtaaaa gcggatgtat caaatcccga 1577041 agatgtacaa aacatgataa aagaaacatt gtctgttttt tctacgattg acattctggt 1577101 taataatgcg ggaattacaa gagacaatct catcatgaga atgaaagaag acgaatggga 1577161 tgacgtcatt aacattaacc tgaagggtgt tttcaactgc acaaaagctg ttacaagaca 1577221 aatgatgaaa cagcgttcag gccgcattat taacgtatcg tctatcgtcg gcgtcagcgg 1577281 aaaccctgga caagccaact acgtggctgc aaaagccggc gtcatcggtt taaccaaatc 1577341 ttctgctaaa gagctcgcca gccgaaatat tacggtaaac gcaatagcgc caggatttat 1577401 ctcaactgat atgacagata aacttgcaaa agacgttcaa gacgaaatgc tgaaacaaat 1577461 tccgctcgcg cgctttggtg aacctagcga tgtcagcagt gttgtcacgt tcctagcttc 1577521 agagggagct cgttatatga caggccaaac gcttcatatt gacggcggaa tggtgatgta 1577581 agttttttct cgaaaatttc atcgtagttt ctctagtttt ttaaaaacga atccactata 1577641 atacttgagg ggaggtgaat tgctatggca gacacattag agcgtgtaac gaaaatcatc 1577701 gtagatcgcc ttggcgttga tgaagcagac gtcaaacttg aagcttcttt caaggaagac 1577761 ttaggtgctg attccctaga tgtagttgag cttgttatgg aacttgaaga cgagtttgat 1577821 atggagattt ctgacgaaga tgctgaaaag attgcaacag tcggcgacgc tgtgaactac 1577881 atacaaaacc agcaataagc tgatgctaaa agtcccgccg aaacgcgggg ctttagccct 1577941 ttattcgtgc agttattaca gcatgccgct tttacgcgcg ctgtatccgg tttagtcaga 1578001 gaagcgcggt gaacctgatg tgcctatgga ggttactatg tcaaaacact cacattataa 1578061 agataaaaaa aagttctata aaaaagtaga acaatttaaa gagtttcaag aacggatttc 1578121 ggttcacttt caaaatgaaa agcttttgta tcaagcattt acacattcat cttatgtgaa 1578181 tgagcatcgg aaaaagccgt atgaagataa tgaaaggctt gaatttttag gtgacgctgt 1578241 tttggaactg acgatctcca gattcttatt tgccaaatac ccggctatga gtgaaggaga 1578301 tttgacgaaa ttgagagccg caattgtttg cgaaccgtct ctcgtttcat tggctcacga 1578361 gctgtcattc ggcgatcttg tcctgttggg taaaggcgag gaaatgacag gcggaagaaa 1578421 gcgtcctgct ctattggcgg atgtttttga ggcatttatc ggagccttgt accttgacca 1578481 aggattagag ccggtcgaaa gtttcttaaa agtttatgtg ttccctaaaa ttaacgatgg 1578541 tgctttttct catgtgatgg atttcaaaag ccagctgcag gaatacgtgc agcgggacgg 1578601 caaaggctct ctggagtata aaatctccaa cgaaaaagga cctgcgcaca accgtgaatt 1578661 tgaagccatc gtatctctaa aaggtgaacc actcggagtc ggaaacggcc gttcaaagaa 1578721 agaagccgaa cagcacgctg ctcaggaagc tttagctaaa ttgcaaaaac accatacgaa 1578781 acaataaaat cccccttatg actcaggggg atttcagtat gtatgccgtc ttatttgacc 1578841 aatgtttatg atagaattga aatacttatt acataaggag gatcgctatg ttcctcaaac 1578901 gtttagacgt tataggattt aaatcatttg cagaacggat ttccgtagac ttcgttaaag 1578961 gcgtgacagc agttgtcggg ccgaacggaa gcggaaaaag caacatcacg gatgccattc 1579021 gctgggttct cggcgaacaa tcggcacgct ctcttcgcgg cggaaaaatg gaagacatca 1579081 tttttgctgg gagtgattca agaaagcgat taaatctagc tgaagttacg cttactcttg 1579141 ataatgatga tcatttcttg ccaattgact tccacgaggt gagtgtcaca agacgtgtgt 1579201 acagatcagg tgagagtgag tttctgatta acaatcagcc atgccgcttg aaagatatta 1579261 ttgatttatt tatggactct gggcttggta aagaagcatt ttctattatc agccaaggga 1579321 aagtggaaga gatcctgagc agcaaagcgg aggatcgccg cagtatcttt gaagaagcgg 1579381 ccggggtgct taaatataaa acgagaaaga aaaaagcaga aaataaactg tttgagacac 1579441 aggacaatct aaatcgggta gaagatatat tacatgagct tgaaggacag gttgaacctc 1579501 ttaaaattca agcttcaata gcgaaagact accttgagaa aaagaaagag ctggagcatg 1579561 ttgaaattgc gctgactgcc tatgatatcg aagagctgca tggtaaatgg tcgactctta 1579621 aagagaaagt gcagatggca aaagaagaag agcttgctga atcgtctgct atttctgcga 1579681 aagaagcaaa gattgaggat acaagggaca aaatacaagc gcttgatgag tcagtagatg 1579741 agctccagca agttttactg gtaactagtg aagagctgga aaagcttgaa ggccgtaaag 1579801 aagtcctgaa agaacgaaag aaaaacgctg tgcaaaacca agaacagctt gaagaagcca 1579861 tcgttcagtt ccagcaaaaa gaaacggttc tgaaagaaga gctttcgaag caggaagctg 1579921 tcttcgaaac gcttcaggct gaggtgaagc agttaagggc gcaagtaaaa gaaaaacagc 1579981 aggctctcag tcttcacaat gaaaatgtcg aagagaaaat cgagcagctg aaaagtgatt 1580041 attttgagct gttaaacagc caggcttcga tacgcaacga actccagctt cttgatgacc 1580101 agatgtccca atccgctgtc acattgcaga gacttgcgga caacaatgaa aagcacctgc 1580161 aggaacggca tgatatttct gcgcgtaaag ccgcatgtga aacggaattt gcccgaattg 1580221 agcaggagat tcacagtcaa gtcggtgcat atcgtgatat gcagacaaaa tatgagcaga 1580281 aaaagcgcca atacgaaaaa aatgaatccg ctctgtatca ggcataccaa tacgttcagc 1580341 aagcgagatc aaaaaaggac atgcttgaga cgatgcaggg agatttctcc ggcttttatc 1580401 aaggtgttaa agaagtgctg aaagcgaaag agcgccttgg cggaattcgc ggagcggttc 1580461 ttgagctgat ttctacagaa cagaagtatg aaacggccat tgaaatagcg ctcggcgctt 1580521 ctgctcaaca cgtcgtgacc gacgatgaac aatctgcccg caaagcgatt caatatttaa 1580581 agcagaattc cttcggccgg gcgacgtttc tgcctctttc tgttattaga gaccgccagc 1580641 ttcaaagccg tgacgcggaa acagccgccc ggcattcatc atttctcggg gttgccagtg 1580701 aacttgtcac atttgatcct gcgtatcgaa gcgtcatcca gaatcttctt ggaaccgttc 1580761 tgatcacaga ggacttaaag ggtgcaaacg agcttgcgaa gcttctcggg caccggtacc 1580821 gcatcgtaac ccttgaggga gatgttgtga accccggtgg ttcaatgacg ggcggcgcgg 1580881 ttaaaaagaa aaataactcc ctccttggaa gaagccggga gctagaagat gtgacgaaac 1580941 ggctcgctga aatggaagag aaaacggcac tgcttgaaca agaggtcaaa acccttaagc 1581001 actccattca ggatatggag aaaaaactgg ctgacttaag agaaaccggg gaaggcttaa 1581061 ggttaaagca gcaggatgtg aaaggccagc tgtacgaact tcaagttgcc gagaaaaata 1581121 tcaataccca tttagagctc tatgatcaag aaaaatctgc tctgtcagaa agcgatgaag 1581181 agagaaaagt gcgcaaacgc aagcttgaag aagagctctc tgccgtatct gaaaagatga 1581241 aacagcttga agaggacata gacagactga caaaacaaaa acaaacgcaa tcctcaacga 1581301 aagagtctct ctccaacgag ctgactgagc tgaagatcgc agcggccaaa aaagagcagg 1581361 cttgcaaggg ggaagaggac aaccttgcca gattaaagaa agagctcact gaaacagagc 1581421 ttgcgttaaa agaagcaaaa gaagacttaa gcttcttaac gtcagagatg tcatctagca 1581481 ccagcggcga agaaaagctg gaagaagcag caaaacataa attgaatgac aaaacgaaaa 1581541 cgatcgaact gattgcatta aggcgcgatc agcgcatcaa gcttcagcat gggcttgata 1581601 cgtatgagcg tgagctgaaa gaaatgaaac gcctgtataa acaaaaaaca acgctcttaa 1581661 aagacgaaga agtcaaactt ggacgaatgg aagtcgagct tgataattta ctccaatact 1581721 tacgggagga atacagcttg tcctttgagg gggcaaaaga gaaatatcag cttgaaactg 1581781 atccagagga agccagaaag cgcgtgaagc tgattaaact cgcaattgaa gagctgggta 1581841 ccgtgaacct cggaagcata gatgagtttg agagggtcaa cgaacggtac aagtttctgt 1581901 cggaacaaaa agaagattta acagaagcga aaaatacctt gttccaagtg attgaagaaa 1581961 tggatgaaga aatgacgaag cgctttaacg acacattcgt ccaaatccgc tcacactttg 1582021 atcaagtttt ccgctcctta ttcggaggag ggcgagctga actgaggctc accgatccta 1582081 acgatctgct tcattcagga gtcgagatta tcgctcagcc gccggggaaa aagctgcaaa 1582141 acttaaacct cctgtcaggc ggagagcgtg cgcttactgc tatagcgctc ttattctcaa 1582201 tcctaaaggt tcgtccagtg ccgttttgcg tccttgacga agtagaggct gcgctcgacg 1582261 aagcgaatgt gttccgattt gcgcagtatt taaaaaaata cagcagcgat actcagttta 1582321 ttgtgattac ccacagaaaa ggaacgatgg aggaagcgga tgtgctttat ggcgtaacca 1582381 tgcaggaatc cggtgtttcc aaggtaattt cagttaagct ggaagaaaca aaagaattcg 1582441 ttcagtaacg aggaaagagg ttaaaagatg agctttttta aaaaattaaa agagaaaatc 1582501 acaaaacaga cagattccgt atctgaaaag tttaaggatg gccttgaaaa aacaagaaac 1582561 tcctttcaaa acaaagtgaa tgatcttgta tcccgttacc gtaaagtgga tgaggatttc 1582621 ttcgaagagc ttgaagaggt tcttatcagc gcggatgtcg gttttacaac cgttatggaa 1582681 ttaatagatg agctgaaaaa agaagtcaaa cgcagaaata ttcaagatcc aaaggaagtc 1582741 cagtcagtga tttctgagaa actggtcgag atttataaca gcggagatga gcaaatttca 1582801 gaactgaaca tccaggatgg gcgtttaaac gtaatccttc tggtaggtgt aaacggcgtc 1582861 gggaaaacaa caacgatcgg aaagcttgct cataaaatga aacaagaagg aaaatctgtt 1582921 gtacttgccg ccggagacac ttttagagcg ggagccattg aacagctgga agtatgggga 1582981 gagcgtacag gagtgcctgt cattaagcag acggcaggaa gcgatccggc ggctgtcatc 1583041 tacgatgctg ttcatgctgc gaaagcaaga aatgccgatg tattaatttg tgatacggca 1583101 gggcgtctcc aaaacaaagt aaatctcatg aaagagcttg aaaaagtaaa acgtgttatc 1583161 gaaagagaag ttcctgaagc tccgcatgag gtgctgcttg cccttgatgc cacgaccggc 1583221 caaaatgcaa tggctcaggc aaaagaattc tctaaagcaa caaatgttac cggcattgct 1583281 ttaacgaagc ttgacggtac ggcaaaaggc ggtatcgtcc ttgcgattcg caacgagctt 1583341 cacatcccgg ttaaactagt cggtttagga gaaaaagttg atgaccttca ggaatttgat 1583401 ccagaatcct atgtgtacgg actcttttca gatttagtgg aaaaagccga cgattaagaa 1583461 aaaggcccca acatcttggg gcctttttct tttttatctt cttacttgat aggcgaaatg 1583521 ataaaggctg ttatcagtgg ataccagtct tgactcacca gaaaaaactc tgaatgggat 1583581 gatgtcatag taatgaacgg aaacagatgt gtaatacgta tagtaaccag cagctggccc 1583641 caaatacatt ggaacctcaa atgttccgtt tgcatcagtc gttcctgaag cagtttgtgt 1583701 tgtgtttccg accttcgtgt ccgcttcaaa tcttacgggc gcgtttggca ctggctgtcc 1583761 gttttggtcg agtaatttgc cgcttactgt aatattgtac ttgactcgcc aatattgacc 1583821 ttgtccgtaa ttgattttac cgtatacccc tccatctgtg ctgatatttg tgattgaggc 1583881 cttataaggt gcctcagcag cgtctgcttg ctgtgccggg aaacctattg taaacagggc 1583941 tgccagacat aacataaaca ataaaccgat ttttttcata aaaatcctcc ttaaaatagg 1584001 gttcatatac aatatcggaa taaattggat gatatttagc gtattttgga aaagttaatc 1584061 gccgctttga caagataaaa acttgacagt gtcattaaaa ccgtgtaaac taagttatcg 1584121 taaagggatt tgacttaaca aaggggagag ctcaaatgtc actcgaaaag acaacgagaa 1584181 tgaattatct gtttgatttt tatcagtcgt tgttgacgtc aaaacagaag agctatatgt 1584241 cgctttatta tttggacgat ttctccctag gcgaaatagc cgaagaatat gaggtttcaa 1584301 gacaagctgt ttatgataac atcaaacgaa cagaagcaat gcttgaacaa tatgaagaaa 1584361 agctgctcct tttgaaaaag tttcaggagc gtaaagagat gtttaataag ctgaaggagc 1584421 ttgcttccgg ttcaaaagaa gaggaagaaa ttacagctct gattgaagcg cttgagaaat 1584481 tagattagga ggcggcaaac tatggcattt gaaggattag ccgaccgact gcagcagacg 1584541 atttctaaaa tccgcggaaa agggaaagtc agcgaacaag atgtaaaaga gatgatgcgt 1584601 gaggtccgtc ttgcgctgct tgaggctgac gttaacttta aagtagtcaa ggattttgtc 1584661 aaaaaagtaa gtgaacgcgc tgtaggccaa gacgtcatga aaagtctgac gcccggccag 1584721 caggtcatta aagttgttca agaggaactg actgagctga tgggcggcga agagagcaaa 1584781 atcgccgtcg caaaaaggcc gccgactgtt attatgatgg tcggtctcca aggtgccggt 1584841 aaaacgacaa caagcggtaa gcttgcgaat ctgctgcgca aaaagcataa tcgcaaaccg 1584901 atgctggttg ctgccgatat ttaccgccca gccgcaatta agcagctgga aacactcggc 1584961 aaacagcttg atatgcctgt tttctctctt ggcgatcagg tcagtcctgt agaaatagct 1585021 aaacaggcta ttgagaaagc caaggaagaa cattatgact acgtcatttt ggatacggca 1585081 gggcgcttgc atatcgacca tgaactgatg gatgaactga ccaacgtcaa agaaatcgcg 1585141 aatccggaag aaattttcct ggttgtcgat tcaatgaccg gtcaggacgc tgtgaatgtt 1585201 gccaaaagct ttaatgaaca gctcggttta accggtgttg tgttgactaa gctggatgga 1585261 gacacacgcg gcggggctgc gctttctatt cgcgctgtca caaacacgcc aattaagttt 1585321 gcaggtttgg gcgaaaagct tgatgcgtta gagccgttcc atcctgaacg catggcatca 1585381 aggattctcg gcatgggcga cgtgctgaca ttgattgaaa aagcacaggc cagcgttgat 1585441 gaagacaaag ccaaagagct ggaacaaaaa atgagaacga tgagcttcac attggacgat 1585501 tttctggagc agctcgggca agtcagaaac atggggccgc ttgatgagct tctgcaaatg 1585561 atgccgggtg caggtaaaat gaagggcctg aaaaacatcc aagttgatga aaaacagctg 1585621 aatcatgtgg aagcaatcat caaatcaatg actgttcttg aaaaagaaca gccggatatt 1585681 atcaatgcca gccggcggaa gcggattgca aaaggaagcg ggacatccgt acaggaagtc 1585741 aaccgtctgc ttaagcagtt tgatgaaatg aaaaaaatga tgaagcagat gacaaacatg 1585801 tcaaaaggca agaaaaaagg gtttaagcta ccttttatgt aatcggttat acatgataaa 1585861 accgttgtta agaaaaaaca ctttacaaac acttttatca ttgttaatat actatcttgt 1585921 tgaaatattt tcggaggtgc tagtaaaatg gcagtaaaaa ttcgtttaaa acgtatggga 1585981 gcaaaaaaat ctcctttcta tcgtattgtt gtagcagatt ctcgttcacc acgtgacggc 1586041 cgtttcatcg aaacagtcgg aacttacaac ccggttgcaa aaccagcgga agtaaaaatt 1586101 gacgaagagc ttgctcttaa atggcttcaa actggagcga aaccatctga tacagttcgc 1586161 aacttgttct ctagccaagg aatcatggaa aaattccaca acgctaaaca aggcaagtaa 1586221 tgactgatca acacttggaa gatttgattg tccacattgt gacgccgctt gttgatcatc 1586281 cagatgacat tcgcgtcata agagaagaaa ccgatcaaaa gattgcgctg cgcttatctg 1586341 tccataagtc agataccggt aaagttatcg gaaagcaagg ccggactgca aaagcgattc 1586401 gaacagctgt atttgcagct ggcgtacagt cttctaagaa agttcaattt gaaatatttg 1586461 actaaaaggg agagggccgg cacctcccct ttttttacac gcaaaaaaag ggtaaactga 1586521 tagaagctta ggcaaaatag aaaagcctgg acgagtaaaa gttttaaaag cggggagctt 1586581 ggtgcgatgc aaattattca ccgtgtagcc gttatgcaag tcttaaccga gcgcagtaaa 1586641 gaaaagcttt tagcttcttt tgctgagaag aaacaaatgc ttgaacgaga atgcagccag 1586701 ctctattttc agcttagaaa acatgagaaa gaacagcaaa accctaatat gattgaacaa 1586761 tttaaaaagg caatagaaaa gcgaaaagat gatataaaaa tcattgattt tcaaattgct 1586821 caagtacata cattgccgct tggcagtgag ttgaaagaaa aggaagtcga tgcgctgctg 1586881 acgattgaag ccggggatga ctggcatgag aaaacagcag cgaacaccat cgtcataaaa 1586941 gacggaaaag taattgaaat tcgccagagg tgatcatatg acaaagcgat ggtttaatgt 1587001 aggcaaaatc gtaaataccc acggaatcaa aggcgaagtg cgggtgattt caaaaacaga 1587061 ttttgccgaa gaacgataca agccgggaaa cacgctgtat ttgtttatgg acggccgtaa 1587121 cgaaccagtg gaggtaacgg taaacacaca tagactgcat aagcaatttc atctcctgca 1587181 gtttaaagaa agacaaaacc taaatgaagt agaagagctg aaaaacgcaa tcattaaagt 1587241 tcctgaagaa gaattaggag agctgaatga gggtgaattt tatttccacg aaattattgg 1587301 gtgtgaagta tttactgaag aaggcgaact catcggaaag gtcaaagaaa ttttgacgcc 1587361 tggagccaat gacgtttggg tcatcggacg aaaaggaaaa aaagacgcac tcattcctta 1587421 cattgaatca gtggttaaac atatcgatgt cagggaaaag aaaattgaga ttgaactcat 1587481 ggaagggtta atagacgaat gaaaatcgat tttttgacgc tgtttcccga aatgtttgaa 1587541 ggcgtgctcg gctcatcgat tcttcaaaaa gcccaggaaa aagatgcggt gcagtttcaa 1587601 gtcgtaaatt tccgagagta ctctgataac aagcacaata ctgttgatga ttatccttat 1587661 ggcggcgggg caggcatggt tctcaagccc cagcctgttt ttgacgcggt cgaggacctg 1587721 acatcaaagg cagccgctgc tccgcgtatt atcctcgtat gcccgcaagg tgagcgtttt 1587781 acccaaaaaa aagccgaaca attagctaag gaagagcatt tgctgttcat ttgcggccac 1587841 tatgaaggct atgatgaacg cattcgcgag cacttggtaa cggatgaaat atcaattggc 1587901 gactttgttc tgacgggcgg tgagctccct gcaatgatga tcgcagacag tgtggtcaga 1587961 ctgcttccgg gtgtactggg taaagaggct tcccatattg aggattcctt cagcaccgga 1588021 cttttagagc acccgcatta tacaagaccg gcagattaca aaggtttaaa agtgcctgaa 1588081 acactcttgt caggaaacca tgcaaaaatt gaagaatggc ggaataaaga atcgatcaga 1588141 aggacctacc taagacgtcc ggatctgttg aaagaccacc cgcttacaga gcagcaaaga 1588201 aagtggattt ctgaatggga aaaagaatag attttattgc ataggctatg aaattgtgat 1588261 aagatactac ttgtggctta agcgggctta tccgctgcaa gcttgaaaac gatgttccgc 1588321 tgtgccggtt tttgtggcca agagcatctg ttggaaggag ttgaaaacga tgcaaaaact 1588381 aattgaagat atcacaaaag aacagcttcg tactgatctt cctgcgttcc gtcctggtga 1588441 cactttacgt gtacacgtta aagttgttga gggtaaccgt gagcgtatcc agatctttga 1588501 aggtgttgtg attaagcgtc gtggtggtgg aatcagcgaa acgttcacag ttcgtaagat 1588561 ttcttacggt gttggcgttg aacgtacttt cccagtacac acaccaaaaa tcgcgaaaat 1588621 cgaagttgta cgttacggta aagtacgccg tgctaaactt tactacctgc gtgaacttcg 1588681 cggaaaagcg gctcgtatta aagagatcag acgataatga taacgaacga aaagagcttg 1588741 ttacctgtaa caagctcttt ttttatacag aatttgaaaa tgccggacag gcatcgtaaa 1588801 atacataaag gacaacaatg aatcatgcat actgaagata aaggcggtgt tcgtgtcaca 1588861 tgacaattca atggttcccg ggccatatgg caaaagcaag aagggaagta accgaaaaat 1588921 taaaattaat cgatatcgta tatgaattgg tagatgccag aattccaatg tcatcaagaa 1588981 acccaatgat tgaagatatt ctaaaaaaca agccgcgaat tatgctgtta aacaaggctg 1589041 acaaagcaga tgcggcagtt acacagcagt ggaaagagca ctttgagaac caggggatcc 1589101 gctctctgtc tattaattct gtaaatggac aagggttaaa tcaaattgtg cctgcatcaa 1589161 aagagatcct ccaagaaaaa tttgaccgga tgcgtgcgaa aggtgtgaag ccgagagcga 1589221 ttcgcgcttt gattatcggc attccaaacg tcggaaaatc aacgctcatc aaccggcttg 1589281 caaagaaaaa catagcaaaa acgggagaca gacctggtat tacgacttct caacagtggg 1589341 tcaaagttgg gaaagaatta gagctattag atacaccggg aattttgtgg cctaaatttg 1589401 aggatgagct tgtcggtttg agactggcag tcaccggggc tattaaagac tcgattatca 1589461 atttgcagga cgtggccgtg tttggtcttc gttttctcga agaacattac ccagaacggc 1589521 ttaaagagcg ttatggcctt gatgagatcc cagaggacat tgccgagctg tttgatgcaa 1589581 taggtgaaaa gcggggctgt ctcatgagcg gtgggctcat caactacgat aagacgactg 1589641 aagtcatcat tcgcgatatt cgcactgaaa agttcggcag gctgtcattt gaacagccga 1589701 cgatgtaaag gcgcgcagaa atgcgggtct ttattttttc ttggctgaac cgatacatac 1589761 agtaagggag aagagaaagt gaatacatta accgtaaagg acattaaaga ccgtttgcag 1589821 gaagtgaagg atgcacaaga cccatttatt gcccaatgcg aaaacgaccc gagaaaaagc 1589881 gttcaaacgc ttgtagagca atggcttaaa aagcaagcga aagaaaaagc gctgaaagaa 1589941 caatgggtga atatgacttc ctatgaaagg ctggcaagaa acaaaggatt tcgcttgatt 1590001 gcaggtgttg acgaggtcgg ccgggggcca ttggcaggac cagttgtcgc cagcgcagtc 1590061 atccttccag aggaatgtga aatacttggg ctgacagact ccaaaaagct ttcagagaaa 1590121 aaacgcgagg aatattacga gcttattatg aaggaagcac tggcggtcgg gataggaatt 1590181 gtagaagcta ctgtgattga tgagatcaat atatatgaag cttcaaaaat ggcaatggtg 1590241 aaagcgatac aggatttgtc ggatacacct gattatttgc ttgttgacgc aatgacactt 1590301 ccgctcgaca cggctcaggc gtcaattata aaaggcgatg ccaaaagcgt gtctattgcg 1590361 gcaggtgcgt gtatcgcaaa agtgacgagg gaccgaatga tgagcgctta tgccgaaacg 1590421 tatcccatgt acggctttga aaaaaataaa ggctatggga caaaagaaca tttggaagct 1590481 ctcgctgcat acggcccaac tgaattgcac cgcaaaactt tcgctcctgt tcaatctttc 1590541 agataaatca ccatggacaa ggaggcacct ttttaaaatg aacatacgaa atgatgtgca 1590601 aaaggcgctg cagcaccttt tcgggcgtac agccgtcccg caggaaacat caaaagtaaa 1590661 cgaagcgcta aacggggaga agcgtctcct cttaggaaaa gtgcttcgtt tactaggaga 1590721 tcagcatgcc ctgatccaag tcggcaatca aactgttcag ggaaaacttg aaactcagct 1590781 tcgtcctcag gcatactatt ggttttccta cgaaaaaaaa acggcagagc aaacaggccg 1590841 tcttcaggtc gttcaaagct ttgatcaaaa tcctaaaacc attcaggatg cagctggcaa 1590901 acttttaaat gctatttcag tgaagacgtc aaacgcagct ctcatgatga caggagcgat 1590961 gctgaaaagc aaaacacccg taacagaaaa tgatatcaaa acagctgtcc gctggatgga 1591021 cacgctgcct tcgcaagaca caaaaaaagc agttgaaacg gttctcttcg ctttaaagcg 1591081 tgatcttccc attcactccg agattttgaa tggtgttcac gctgtgaaat cgcctgttcc 1591141 gttgcatcag cacgtatccc agctgctaca ggcaatcgac caaaaccctc agcagagcca 1591201 aatgatgtca aagctaaagg aagcagtcac ggtgctttta aatagtgaaa tcgatgtcca 1591261 tgcagaacgg ctgattgata agcttatttc tttaaccgac aatacgaaag caccttctcc 1591321 gacgaataca gctggaagca gggagcttag cacaccagct ggctcccccg gaaaagccag 1591381 cctgccgatt gcaaatcaca cagcagaaca gggaagcata caagaagagc ctgttaaaac 1591441 agcagcagac attccaatta aagaagcccg ccagctgctg gtgaagctga cggaatctgc 1591501 tgaaaaaaac agtctccaaa ttgtgaaaga agcagcaaat tggattaaag cggctgcttc 1591561 atcgggtgat agtaagtcac ttgcagcttc agctgtttta caggcggcac aagtcacaga 1591621 tcaggaagcc gaagtctttt taaaggctgt tcagcagaca gcaccccatt tggcggataa 1591681 ggcagatgtt ctttctttct tatccaaagt gaaaacggca atcggcgcaa gggacgaggt 1591741 tgcgttcatt aaagcgtttg aacaaggaag cgcagtcaca tctggcgaaa tgcaatccat 1591801 caagctggct ctttctgcct taagagcatc gcatgaggta gccgaaccag tcaaacaaga 1591861 agccgatcag ctttttcata aattaaatgg ccagcttttc atgcagcagg accatccatc 1591921 atacagccaa attgtaatgt catttccgat gttttcgaag tcaggggttc aggacatgac 1591981 tgttctgttt aaaggaaaga aagaagcgga tggaaagctt gatccttccc attgccgcct 1592041 tttgtttttg ctgcagcttg atacactaaa agaaaccgtc gttgattgct tggtacagca 1592101 aaaagtcatg accattacaa tagagactga tttcgagctg caggctgcga tcgatccgat 1592161 ggtgcccgcg cttaaacagg ggctaaagga aatggggtac agcctttcag gggtaaacgc 1592221 taaaaaaagg gttcacaccg aagaaaaggc ttcaatcgat caatatataa caagtatcag 1592281 tgatcaggaa gtggatgtga aaatatgaaa gagcagacac cgatcagaaa agctgttgct 1592341 ctccattatg acgaacaaaa agacaaggcg ccgagagtga ttgccacagg gaagggccat 1592401 gtagctgaca acattataaa agaagcgaaa aaagcagggg tcccgattca agaagatcgg 1592461 acccttgtcg aattaatgcg ccatttgacg gtagatgatc aaattcctga agctctttat 1592521 gaaacggtag ccgagatttt ttcattcatt tacaaattgg acgaaagcgt aaaaaacaaa 1592581 aaatagctaa aatattcccc atccttcttt gaaatttatg tttttaataa agtaaaagtt 1592641 tgaatgttta gaaggattaa aagattttgc atcgaactgt agacaattct tccagtatta 1592701 ttatagaatg aaagcgcagt ctattttagt tttgttacat aagttaggag gatgggaaat 1592761 gaatatccat gagtaccagg gaaaagaagt cctcagaaaa tatggggtat ctgttcctga 1592821 aggtaaagtg gcttttacag cagaagaagc agttgagagt gcaaagagct tatccagctc 1592881 ggtttatgtc gtaaaggctc aaattcatgc tggcggtcga ggcaaagctg gtggggtaaa 1592941 aatagcaaaa tcattagacg aagtaaaagc gtatgccgaa gaactattag ggaagaccct 1593001 agttacacat cagacgggtc cggacggcca agtaataaaa cgcttactta ttgaagaagg 1593061 ctgcgatatt aaaaaagaat attacatcgg tctagtgctt gaccgcgcca cttcaagaat 1593121 cgttttaatg gcttctgaag aaggcggaac ggaaattgaa gaggttgcgg agaaaacacc 1593181 agaaaaaatc aaaaaagctg tcattgatcc agctgttggc cttcaaggct atcaagccag 1593241 agaaattgca ttcgctatta atattccaaa agagctcgtg ggaaaagctg ctaaatttat 1593301 gcttggacta tataaagcgt ttgttgagaa agactgctca atcgccgaaa tcaatccgct 1593361 tgttgtgact ggcgacggaa atgtgatggc gcttgatgca aaattgaatt ttgacagcaa 1593421 tgcgttgtac cgacaaaagg acattatgga atacagagat ttggatgaag aagatccgaa 1593481 agaaattgaa gcgtccaaat atgatctaag ctacatttcc cttgatggaa atatcggctg 1593541 tatggtaaac ggcgcgggac ttgcaatgtc tacgatggat attatcaagc attatggagg 1593601 agaaccggcc aacttccttg atgtgggcgg cggtgcaacc gcggaaaaag tcacggaagc 1593661 atttaaaatc attctttctg atcaaaacgt taaagggatt tttgtcaaca ttttcggcgg 1593721 cattatgaaa tgtgatgtca tcgcagaagg ggttgttgaa gcgactagac aagttggttt 1593781 gacattgccg cttgtcgtcc gtcttgaagg cacaaacgtg gatctaggga agaaaatcct 1593841 tagtgaatca ggattaaaca ttacatctgc ggaatcaatg gctgacggcg cgcagaaaat 1593901 cgtatcctta gtttaagaaa gaatgaaagg caggggacca aataatgagt gttttcatta 1593961 ataaagatac aagagttatt gtgcaaggga ttacaggttc taccgcttta tttcatacga 1594021 agcagatgct tgaatacggc acaaatatcg ttggcggtgt aacacctgga aaaggcggaa 1594081 cagaagcgga aggtgttcct gtatttaata cagtggctga agcagttcaa acaaccggcg 1594141 ctaacgcgtc tgttatatat gtgcccgcac cgtttgcagc tgatgcgatt atggaagcgg 1594201 tagatgcgga gcttgatctc gtgatttgta tcacagaaca tatcccggtt ttggatatgg 1594261 tgaaggtcaa acgcttcatg gaaggcaaga aaacgagact gatagggccg aactgtcctg 1594321 gtgtcattac gcctgaagaa tgtaaaatcg gcattatgcc cggatacatc cataaaaagg 1594381 gtcatgtagg cgttgtatca cgttcaggaa cattaacata cgaagcggtg caccagctct 1594441 cagaagcggg tgtagggcaa tctacagctg ttggaatcgg cggcgaccct gtaaatggaa 1594501 caaactttat tgacgtttta aaagcgttta acgaagatcc tgacacacac gcagtcatca 1594561 tgattggcga aatcggcggt acggccgaag aggaagcggc agagtgggta aaagccaaca 1594621 tgacaaaacc ggtagtcggt tttattggcg gtaaaacagc acctcctggg aagcgcatgg 1594681 ggcatgcagg cgccattatt tccggcggga aagggacagc tgatgaaaaa atcaaaaccc 1594741 ttaatgcatg cggaatcgaa gttgcagaga caccttctgt catgggtgaa accttaatca 1594801 aggtgctgaa agagaagaac ttgttcgaaa cttgtaaaac gcattaataa aaaagggaca 1594861 gccgtcaagg ctgttcctgc tttttctaac aaaaggaggt caatctattg gatcaggccg 1594921 ctgtctgcct aacgatttgc agaatcaatc aattattatc cccatccctt ctattaaaat 1594981 ggtggaaagc cgatccgtct atgtcgctga catcacccgt gttacaaacg gttactcgtg 1595041 atcaaataaa agcagctgca ttaaaaaacg aaatagaaca attttatcca aagctcccgc 1595101 gtgtacttgc tgcttatcgt gagcaaggca ttaacaccat ccctatttct tcaaagcaat 1595161 atcctttctg gcttaaaagc atttatgatc cccctgccgt actgtttgca aaaggtgata 1595221 tgactcttct ttcgaaaggg agaaaaattg gaattgtagg cacaagaaat ccaacagctt 1595281 atgggaaaca agttgtcaat catcttacaa aagagatctg tcgtaaaggt tgggtgattg 1595341 tcagcggact ggcgtctggg atagacggaa tgtcccatgc tgcaagtatt aaggcgaagg 1595401 ggcggacaat tggcgtcatt gcaggcggat ttcaacacat ttatccccga gaaaaccttc 1595461 agttagcaga tcacatggct aaacaccata tcctgctgtc agagcaccca cctgaaacta 1595521 aaccccaaaa atggcatttc cctatgagaa accgtattat cagcggacta agtgaaggcg 1595581 ttattgtcgt tcagggcaaa gaaaaaagcg gttcgctgat tactgcctat caagcattgg 1595641 aacaagggag agaggtattt gccgtacccg gttcattgtt tgacccttac gccggaggtc 1595701 ctataaaact gatccagcag ggggctaaag ccatatggtc agcagaggat attttcgagg 1595761 aacttcctga gagaaacgtt caatatacgg aacccttttg aattatcgtt tgacaaacgg 1595821 tattgtaata tttaataata gtgaggattt aaagttgcat attgttttct atttaattaa 1595881 tgacgttcat gataaagaat gaaatgttga aagccaaata aagacagctg caaaaataaa 1595941 attgaaatat cttgaaaaga gagagaacac ctcttgaggg ggatgaaaat gtctgattat 1596001 ctagtcatcg tggaatcgcc cgctaaggcg aaaacgattg aacgttactt aggtaaaaaa 1596061 tataaagtaa aagcatcaat gggacatgtc cgggatcttc caaaaagtca aatgggagtt 1596121 gacatagaac agaattttga accgaaatat attaccattc gaggtaaagg cccggtatta 1596181 aaagagctga aaacggctgc gaaaaaagcc aaaaaagtgt atctcgcagc tgaccccgac 1596241 agagaagggg aagcgattgc atggcatttg gcacacagtc ttgatttaga tctcaactca 1596301 gactgccgtg tggtgtttaa cgaaattaca aaagacgcta ttaaggaatc gtttaagcat 1596361 ccccgcatga tcaatatgga tttagtggat gcacagcaag cgagacgtat tttagacagg 1596421 cttgtcggat ataaaatcag tccaatctta tggaaaaaag tcaaaaaagg gcttagcgca 1596481 ggacgcgtgc aatccgttgc cctccgtttg attattgacc gtgaaaaaga gattaacgac 1596541 tttaagcctg aggaatattg gacaattgac ggtacgttct taaaaggtca agaaaccttt 1596601 gaagcgagct ttttcgggaa aaacggcaaa aaacttcctt taaatagtga agctgatgta 1596661 aaagagattc tttctcagct caaagggaat caatatacag ttgaaaaagt aaccaaaaag 1596721 gaacgcaaac gtaatcctgc tttgcctttt accacttcta ccctgcagca ggaagcggct 1596781 cgcaagctca atttcagagc gaagaaaacg atgatgattg cacagcaatt atatgaagga 1596841 attgatttag gaagagaagg aacggttggt ctgatcacgt atatgagaac ggattcaacc 1596901 cgtatttcaa atacggctgt tgatgaagca gctgcattta ttgatcagac atatggaaaa 1596961 gagttcctag gcggaaaacg gaagcctgcg aaaaagaatg aaaatgccca ggatgcccac 1597021 gaagcaattc ggccgacatc agttcttaga aaaccaagtg aattaaaagc agtcctcggc 1597081 agagaccaaa tgagactgta taaattaatt tgggagcgtt ttgttgccag ccaaatggca 1597141 ccggctgttc tcgatacaat gagtgtcgac ctgacaaaca acggtttgac atttcgtgca 1597201 aatggaagta aagtcaagtt ttccgggttt atgaaggtgt atgttgaagg aaaagacgat 1597261 caaatggaag aaaaagaccg gatgctgcct gacttacaag aaggcgacac ggtattatca 1597321 aaagatatag aacctgagca gcattttacc cagccgcctc cgcgatatac tgaggcccgg 1597381 cttgttaaaa cccttgaaga acgcggtatc ggccgtccat ccacatatgc tccgacactt 1597441 gatactattc agcggcgcgg ctacgtggca ttggataata aacgtttcgt tccgactgaa 1597501 ttaggtcaga tcgttcttga cttgatcatg gagtttttcc ctgagatcat taacgttgag 1597561 tttacagcta aaatggagag agatcttgat catgttgaag aaggaaatac cgaatgggtc 1597621 aagattatcg ataatttcta caccgatttt gaaaaacgcg tcaaaaaagc cgaatcggaa 1597681 atgaaggaag ttgagattga accagagtat gctggagagg attgtgaatt gtgcagttct 1597741 ccaatggtat ataaaatggg acggtacggt aaattcttag cttgctccaa cttccctgac 1597801 tgccggaaca cgaaaccgat tgtgaaacaa atcggtgtga agtgcccgag ctgcggagaa 1597861 ggaaacattg ttgagcgaaa atcgaaaaag aaacgggtgt tttacggctg tgaccgttat 1597921 ccggactgtg aattcgtatc atgggacaaa ccaattgaac gaaaatgccc gaaatgcgga 1597981 aaaatgctcg tcgagaaaaa actcaaaaaa ggtatacaag tccaatgcgt ggaatgcgat 1598041 tataaggaag aaccacagaa gtagcggtga gcagggtctt gctcaccttc tttgtgtgtt 1598101 aaaagaaggc cttgaataat aaactaggag atgtgaaaga tgaaccaaca aacagtgaat 1598161 gtaatcggag ccggactcgc aggaagtgaa gcagcatggc agcttgccaa acgtgggatt 1598221 caagtcaaat tgtatgaaat gcggccagtt aaacaaacgc ctgcgcatca tacagataaa 1598281 tttgctgagc ttgtctgcag caactctctt cgctctaata cacttgctaa cgctgtcggt 1598341 gtattaaagg aagaaatgcg tgcgcttgat tcagccatta tcgctgcggc tgacgaatgt 1598401 tcggtgcctg ccgggggcgc tcttgcagta gaccgtcatg aatttgccgc aagtgtgaca 1598461 aatcgggtga aaaatcatcc aaacgtaacc gttattaatg aagaagtgac tgaaattcct 1598521 gaaggcccta ctatcatcgc aacgggtccg ttaacatctg aatcgctgtc tgcccagctg 1598581 aaggagctga ctggagagga ctatttatat ttttatgacg cagcggcgcc aattgtagaa 1598641 aaagacagcc ttgatatgga taaagtgtac ctgaaatccc gttatgataa aggtgaagca 1598701 gcatatttga actgcccgat gacagaagaa gagtttgacc gttttcatga agcattaaca 1598761 tcagcagaaa cagtgccgtt aaaagaattt gaaaaagaga ttttctttga aggctgcatg 1598821 ccgattgaag tcatggcaaa acggggtaag aaaacaatgc ttttcggtcc gatgaaacca 1598881 gttggtctag agcatcctgt tacaggaaaa cgcccttatg ccgtcgttca gctcagacag 1598941 gatgatgctg cgggaacact ttataatatt gtaggattcc agacacattt aaaatgggga 1599001 gaccaaaagg aagttctcaa gttgattcca ggacttgaaa atgtagaaat cgtcagatat 1599061 ggcgtgatgc atagaaacac atttattaac tctccaagcc tgttaaagcc gacttatcaa 1599121 tttaaaaacc gcagtgatct gttctttgca ggccaaatga cgggagtaga aggatatgtg 1599181 gaatcagctg cctcaggact tgtagcaggc attaatgcgg cgaagcttgt attgggagaa 1599241 gagcttgtga tcttccctca ggaaacagca attggcagta tggcacatta tattacaaca 1599301 acaaaccaga agaacttcca gccgatgaat gcaaactttg ggcttttgaa agaattgcca 1599361 gttaaaatta aaaataaaaa agaacgaaat gaacaatacg cgaaccgtgc gattgaaaca 1599421 attcaaacaa tttcgaaaac aatataggta ttgattgcaa cctgagcgcg atttgtgata 1599481 ccatttaaaa gcccttcctg gggaggtatt aggcatggag aatgttaaga atttcgtaaa 1599541 gttattcgtt gaatatttac aaattgaaaa aaattattca caatatacta ttgtgaatta 1599601 tgtggattca attgaagaat tcgagacttt cctgcgcgtt caaggtataa atggatttga 1599661 agaagctgca tatcaagata ctaggatttt tttgacagaa gcctatgaaa aaggtttatc 1599721 gagaagaaca ataagcaaaa agatatctgc attaagaagc ttttataagt ttctgatgcg 1599781 ggaaaagctt attgaagaaa atccgtttca gcttgttcat ctgccaaaac aggagaaacg 1599841 gataccgaag tttctatatc aaaaagagct tgaggagctg tttgaagttt cagatataag 1599901 ccagccggcc ggaatgaggg atcaagcgct gttagagctg ctctatgcca ctggaatgag 1599961 ggtcagtgaa tgctgttcca taactattaa cgacgttgat ttatttatgg acactgtgct 1600021 tgttcacggt aaaggcaaga agcagcgcta tatccccttt gggtcttatg cccgcgaagc 1600081 gttgaaggta tacatgaata gcggaagaca gtgcttgctg atgaaggcaa aagaacctca 1600141 tgatctatta ttcgtaaatc aaagaggcgg accgcttaca gcccgtggca tcagacatat 1600201 tttaagcggg cttgttcaaa aagcgtcaag cactttacat atccatccgc atatgcttcg 1600261 acatacgttc gccacgcatc tgttaaatga aggagcggat ttgagaagcg ttcaagaact 1600321 gctcgggcat tccaatctgt cttctacaca gatatacacg cacgtttcga aggaaatgtt 1600381 gagaaacaca tatatgtctc accatccaag agcatttaag aaaaattaaa ggaggccctt 1600441 tatgtcatct tttcatgcga ccacaatatt tgccgtacag cataaaggac gaagcgctat 1600501 gtccggagac ggccaagtaa catttggtca ggctgttgtc atgaaacaca cggcacggaa 1600561 agtgagaaaa ctgtttaacg gcaaagttct tgctggtttt gcgggatctg ttgcagacgc 1600621 tttcacttta ttcgaaaagt ttgaagctaa gcttgaagaa tataacggca acttaaaacg 1600681 ggcggctgtt gagcttgcaa aggaatggcg cagtgataaa gtgctaagaa agctcgaagc 1600741 catgctgatt gttatgaatc aggatacttt gcttctcgta tcgggaacag gcgaggtgat 1600801 cgaaccagat gacggcattc tcgcgattgg atcaggaggc aattacgctt tggcagcggg 1600861 aagagcactg aaaaagcatg ccggggaaag catgtctgca agtgagattg ccagagccgc 1600921 gttagaaaca gcaggcgaaa tttgtgttta cacgaacgat caaatcatac tggaagagct 1600981 tgaatagaaa ggacttgagg cgcatggaaa aaaaaccgtt aactcctaga cagattgtag 1601041 atcggttaga ccaatatatt gtcggtcagc aaaatgcgaa aaaagctgtc gccgtggcat 1601101 taagaaaccg ctatagaaga agtcttctgg atgaaaagct gaaggacgag gtcgttccga 1601161 aaaacatttt aatgatgggt cctaccggcg tcgggaaaac tgaaattgcc agacgaatcg 1601221 ctaagctttc aggtgcgcca tttatcaaaa ttgaagctac taaatttacc gaagtcggct 1601281 atgtaggcag agatgttgaa tcaatggtca gagatcttgt ggagacttct gttcggctta 1601341 taaaagaaga gaaaatgaat gaagtaaagg aacaggcaga agaaaatgca aacaaacgca 1601401 ttgttcgtct gttagttcct gggaagaaaa aacaatctgg tgttaaaaat ccgtttgaaa 1601461 tgttttttgg aggcagccag ccgaatggtg aagatgaggc ggagagccag gaagaagcaa 1601521 acatcgaaga aaaaagaaaa cgaatggcgc atcagctggc tttaggagag ctcgaagact 1601581 actatgtaac agtagaagtc gaagaacagc agccttctat gtttgacatg ctgcagggct 1601641 cgggtatgga gcagatgggt atgaacatgc aggatgcgct gagcggatta atgccaaaga 1601701 aaaagaagcg gcgcaaaatg acagtcagag aagccagaaa agtcctgacg aatgaagaag 1601761 caagcaaact catcgatatg gatgaagtcg gccaggaagc tgttcagaga gcagaagaga 1601821 gcgggattat ctttatcgat gagattgata aaatcgcaaa gaacggcggt gcatcttctt 1601881 ctgccgatgt ttcaagagaa ggtgttcagc gggatatcct tccgattgtt gaaggttcta 1601941 ccgttgtcac aaaatatggt tctgtaaaaa cagaccatgt attatttatt gcagcaggag 1602001 cgtttcatat ggccaaaccg tctgatttga ttcctgagct gcaggggcgt ttcccgattc 1602061 gtgtagaact gaacaaactc acggtagacg acttcgtgag aattttggtt gagccggata 1602121 atgcgctgct gaaacaatat caggcattat tgcagacaga aggtatatct cttgaatttt 1602181 ctgacgaagc tattcataag attgctgaag ttgcttatca tgtgaaccag gacacagata 1602241 atatcggtgc gagacgcctt catacaatac ttgaacgcct attagaagat ttgtcgtttg 1602301 aagctccaga tgtaacgatg gagaaaataa cgattacacc acagtatgtc gaagaaaagc 1602361 tcggaacgat agccaaaaac aaagatttaa gtcaatttat attgtgaaaa atttaatatg 1602421 aggaatgttt aggaggatta tttatcatgg ctttattaca aaaaacaaga attattaact 1602481 ccatgctgca agctgcggca gggaaaccgg taaacttcaa ggaaatggcg gagacgctgc 1602541 gggatgtaat tgattccaat attttcgttg taagccgcag agggaaactc cttgggtatt 1602601 caattaacca gcaaattgaa aatgatcgta tgaaaaaaat gcttgaggat cgtcaattcc 1602661 ctgaagaata tacgaaaaat ctgtttaatg tccctgaaac atcttctaac ttggatatta 1602721 atagtgaata tactgctttc cctgttgaga acagagacct gtttcaagct ggtttaacaa 1602781 caattgtgcc gatcatcgga ggcggggaaa gattaggaac acttattctt tcgcgtttac 1602841 aagatcaatt caatgacgat gacttaattc tagctgaata cggcgcaaca gttgtcggaa 1602901 tggaaatcct aagagaaaaa gcagaagaaa ttgaagagga agcaagaagc aaagctgtcg 1602961 tacaaatggc tatcagctcg ctttcttaca gtgagcttga agcaattgag cacatttttg 1603021 aggagcttga cggaaatgaa ggtcttcttg ttgcaagtaa aattgctgac cgtgtcggca 1603081 ttacccgttc tgttattgtg aacgcactca gaaagctgga gagcgccggt gttatcgagt 1603141 ctagatcatt aggaatgaaa ggtacttata tcaaggtact aaacaacaaa ttcctaattg 1603201 aattagaaaa tctaaaatct cattaatcac aaaaagaacc ctttttgagg gttctttttt 1603261 tatttcaaat aaaggaaatc aataagcttt atttcctggg ttgaaagtct ttctatgtaa 1603321 taattttaat aaattttgca tttttcttca aaaagtttca aaaatgccga aaagaaagga 1603381 gaaaaaacag aaattctgct attttcaggc ttatatcaag gcgagaaatg tagttctaac 1603441 aatctaggac tttataccta gttgcaaaat agataattgt gaggacattt ttttacacga 1603501 acttcataga ctttatgcct gttatttctt acaataagca tatagtttta caattctcga 1603561 caaggatatt gagggtgaaa aaaactgaaa tggaggtaag tggatttgag cttattttct 1603621 ggaacgatac aaaatcttga aaatgccttg agcagagcgg atattaagca aaaagtcata 1603681 actaataata tcgccaatat agatacaccg aactataagg caaaaaaagt ctctttccaa 1603741 aatttattag atcaagaatc ctcgcgtctt gaagcgataa aaacagacta tcgtcatgtt 1603801 gatttttctg atactgattc gaattattca attgttgcga gcggagatac atcgtatcag 1603861 caaaacggaa acaatgttga tgttgacaaa gagatgacag aattggcgca aaatcaaatc 1603921 aactatcaag ctttggttga aagaatgaac ggtaaattta attcgctgaa gaccgtatta 1603981 acaggaggaa aatgatgaca gcttttcata gcttaaatgt ttcagcatcg gctttaacag 1604041 ctcagcgagt cagaatggac gttgtatcat ctaacttagc aaatatggat acgacaagag 1604101 ctaagcaggt gaatggagag tgggtgcctt acagaagaaa aatggtttcc cttcagtcaa 1604161 aaggtgaatc gttctcttcc attctcaatt ctcaaatgag cggaagcggg aatgctggaa 1604221 acggtgtgaa ggtttcaaaa attacggagg atgattcgga ttttaatctt gtctatgatc 1604281 cgacagaccc tgatgcaaac gctgaaggat atgtacaaaa gcctaatgtt gatccattaa 1604341 aggaaatggt tgatcttgtc agcagcacta gatcatacga ggcgaatgtc acggcgatga 1604401 atgccacaaa gggaatgctg atgaaggcgt tagaaatcgg aaagtaggtg aatgaatgtg 1604461 attaatgcaa tttctccttt tcaggttcaa aatactcaaa acactcaaaa tgcaacaaat 1604521 caagtaaaca atagccaaaa aacagattct tcaaatcaaa caagcttttc ggagctttta 1604581 aaaaactcta ttagttcgtt aaatgagtcc caagtagctt ctgacaacat gactaatgcc 1604641 ttggctgcag gaaaagatgt aaatcttgat gaggtcatga tcgctgctca aaaagctagc 1604701 atctctctaa ctgcagcaac agagttccgc aataaagctg tggaagctta tcaggagatt 1604761 atgagaatgc aaatgtaggg ggtctgacga tttagagaaa gagtggaatg accgggggtt 1604821 aacatgaatc gtactctaat gcaaatgaaa aacaaaacga gtgagttttg gaaaaataga 1604881 tctaaattac aaaagatttt aatggttagt gctttagcgg caattattat tattggaatt 1604941 attattagtg tttttgcttc aaattctaaa atggcgccgc tgtacaaaga tttgtctgcc 1605001 gaagaagcag gacaaatcaa agaagaattg gatgcaaaaa aagtgccaaa cgaactttcg 1605061 aatggcggta cagtgattag tgttccggag gatcaggttg attctttgaa agtgcagatg 1605121 gctgcagaag gacttcctaa aacgggatca attgattatt cgttttttgg acagaatgcc 1605181 ggctttggtt tgacagacaa tgagtttgat atggtgaaag tgaaagctac acagacagaa 1605241 ctgtcaaact tgatcaatga aatggacggt attaaaaatt caaaagtaat gattaatctc 1605301 ccgaaagacg ctgtgtttgt cggtgaagag caatctgcag catctgcatc aatcgttttg 1605361 cagattcaac cgggttatac acttgatcaa agccaaatca acggattata tcatctggta 1605421 tctaaaagcg tgccaaacct aaaagaagat aacatcgtca tcatggacca aaattctaca 1605481 tactacgaca aatcagacag cgatgcaggg tcctacgcgg atagttattc ttctcagcaa 1605541 ggaattaagt ctcaagttga aaaagacatt caaaaacatg tacagtcact gctgggtacg 1605601 atgatgggcc aagataaagt cgttgtctcc gttacagcag acattgattt cacaaaagaa 1605661 aatcggacag aagacattgt cgaacctgtg gataaagaaa acatggaagg cattgcagtc 1605721 agcgctgaaa aggtatctga aacatatcag ggcgacggtg cagccaacgg cggaactgcc 1605781 ggaaccggcg aggaagatgt tacaaattat aaggctgacg gtgaaaatac cgaaagcggg 1605841 aactacgaaa aaaacagcaa caaaatcaat tacgaggtta accgaattca taaagaaatc 1605901 gctgaaagtc cttataaggt cagagattta gggattcaag taatggtaga gccgcctgat 1605961 gccaaaaaca ctgcgtcgct atcaactgaa agacaggatg atatacaaaa aatcctttca 1606021 actgtagtca gaacatcttt ggataaagat gaaacgcaaa atcagaattt atctgatgct 1606081 gatatcaata ataagattgt tgtttccgtt cagccattcg acggaaaagt caatttggat 1606141 acaaatacgg aagaatcctc aggtatcccg ctgtgggcat atattgtagg cggtgtttta 1606201 atcgcagcga tcattgttct gatcattatg cttatcagaa agaaacgggc gcaagaggat 1606261 gaatttgagg aatatgagta tgaggttcct caagaaccaa tcaatttgcc tgatatcaac 1606321 gaagaggaaa atgaaacagc ggaatcagtc agacgaaaac agcttgaaaa gatggcgaaa 1606381 gacaagccgg aagattttgc aaaactgctg agaagctggc tggccgagga ttaggaggaa 1606441 ttagaaatgg cgagacgtga tcaagataag cttacaggaa aacaaaaagc agccattctc 1606501 atgatttcct tggggttaga tgtgtcagct tctgtctata agcacttaac cgatgaagaa 1606561 attgaaaggc ttactctgga aatatcaggt gttcgaagcg tcgatcatca aaaaaaggat 1606621 gaaatcatag aagaatttca taatatagcc attgcgcaag attatatttc tcaaggcggt 1606681 ttaagctatg caagacaagt tctggaaaag gcgcttggag aggataaggc ggagaacatt 1606741 ctaaacaggc tgacttcttc tttgcaggtt aaaccatttg attttgccag aaaagcggag 1606801 ccagaacaaa ttttgaattt tatccagcaa gagcatccgc agacgatggc gttaatcttg 1606861 tcttatttag atccagtgca ggccgggcaa attttatccg agctgaaccc tgaagtgcag 1606921 gctgaggttg cgagaagaat cgcggtcatg gatagaacgt ctccagaaat aattaacgag 1606981 gtagaacgga ttctggaaca aaaattatct tctgcattta ctcaggatta tacacaaaca 1607041 ggcggaattg aagctgttgt ggaagtgtta aacggggtag acagagggac agagaagacg 1607101 atcttggatt cattggaaat tcaggatccc gatcttgctg aagagattaa aaagcggatg 1607161 tttgtcttcg aagatattgt cacacttgat aaccgtgcaa ttcagagagt cattcgcgat 1607221 gttgagaacg acgatttgct cctttcatta aaggttgcaa gcgaggaagt caaagaaatt 1607281 gtgttcaaca atatgtcaca gcgtatggtt gaaaccttca aagaagaaat ggagtttatg 1607341 ggccctgtac gtttgaaaga tgtagaagaa gctcaatcaa gaattgtaag catcgtcaga 1607401 aagcttgaag aagccggtga aattgtaata gcaagaggcg gaggggatga tattattgtc 1607461 taatatcatt aaacaagaat catctatttc tccacaaaag gaaaaaagaa aactttctat 1607521 acaagaggtg cgtattgatc attctcacct tttgcaggct gaagagaacc cggaggcgct 1607581 tatggcccga gtgaaagagg aagctgaccg gatttctgag caggcaaaca gtcatataga 1607641 aaatattcgc cgtcaaattg aacaggagaa aaacgattgg gcggctgaaa aacagaagct 1607701 tattgaagaa gcaaaagccg agggctttga acaaggagta gcgctgggca aagctgaggc 1607761 aatgaaacag tatgcagaac tgatcggcca agcaaacagt ataactgaaa tgtccagaaa 1607821 agctgttgag gacaagcttg aagacgctaa tgaagaaatc gttgagcttg ccgttgccct 1607881 agcaaaaaaa gtttggcagc aaaagtctga tgataaagag gctttcctcc tgcttgtaca 1607941 acaggttata aacgaagtga aggaatatga cgatatatca atttatgttg atccatatta 1608001 ctatgagaca atctttcagc aaaaagatga aatccagcag cttctttata aagaatgtcg 1608061 gcttggcata tatgctgatg aaaaagctca aaaaggaacc tgttatattg aaactccttt 1608121 tggcagggta gatgcgagtg ttgacacaca attgatgcaa ttgaaagata aacttctgac 1608181 agcgctggaa gcaggtgcag ctgaatgaag acacagagtc tgatagattg tatagaaatg 1608241 acagactcgt ataaacggta cggaaaagtc aagcgggtaa tcggcttgat gattgaatca 1608301 aaagggccag caagctcaat tggtgacctg tgcctgattt atgcaaaagg acagtctggg 1608361 aaagtcatta aagctgaggt agtcggcttc caggaagaaa atattttgct tatgccttat 1608421 ttagaggctg cgagcattgc acctggcagc attgtagaag ctactgggga atcacttcgg 1608481 gttaaagttg ggaccggact gatcggacaa gtcatcgatg cttttggaga accgcttgac 1608541 ggaaagcttc tgccgaaagg gctttcgcct gtatcaacgg agcaatcacc gcctaacccg 1608601 atgaaacggc cgcctatccg tgaaaagatg ggtgttggag tcagatcaat tgacagcttg 1608661 ctgacagtcg gtaaaggcca gcggattgga atttttgcag gaagcggtgt cggaaaaagc 1608721 accttaatgg ggatgatcgc caagcagaca gaggctgact taaacgtcat tgcacttgtc 1608781 ggagaacgcg gacgagaggt tcgggagttt attgaaaaag atctggggaa agaggggctg 1608841 aaacgatcga ttgtagtcgt tgccacctca gaccagccag cattaatgag attgaaagcg 1608901 gcatatacag cgactgcaat tgccgagtat ttccgagata aaggccaaaa tgtcatgttt 1608961 atgatggatt ctgttacaag ggtggcaatg gcgcagcgag agattggact ggctgcagga 1609021 gagcctccga cgacaaaagg ctatacacct tcagtgttcg ctattttacc tcgtttacta 1609081 gaacgaacag gtgcaaacga gcatggaacc attacggcat tttatacagt gttggtagat 1609141 ggggatgaca tgaatgagcc gattgccgat accgtacgcg gaattttaga cgggcatatt 1609201 gtgttggaca gggcgcttgc caataaaggc cagtttcctg cagttaacgt actaaaaagc 1609261 atcagcaggg tgatgtcaaa catttcaaca aaacagcatc tggatgcggc aaataaattc 1609321 cgtgaacttt tatcgacata tcaaaattcg gaagatctca ttaatatcgg agcttacaaa 1609381 agaggatcat ccagagaaat tgatgaagcg atacaatttt atccgcagct tattcaattt 1609441 ttaaagcagg gaacagacga accggcttta ttggaagaaa gcattgctgc attaactagt 1609501 ttgacaggaa atgaggaata aacgtggctt atcaatttag attccaaaag ctgctggaac 1609561 taaaagaaaa tgaaaaagac caatccttat ccgaatatca gcaatcagtt tctgaatttg 1609621 aaaacgttgc tgaaaaatta tatgagaata tgagcaaaaa ggaattgctg gaacaaaata 1609681 aggaaaagaa attaaaaagc ggcatgagtg tacaagaaat gaggcactac caacaatttg 1609741 tctcaaatct tgataatacg atctatcact atcaaaagct tgtcattatg aaaagaaatc 1609801 aaatgaatca aaaacaagaa attttgacag agaaaaacat tgaagtgaaa aagtttgaaa 1609861 aaatgcgtga aaaacagttt aaaatgtttg ctcttgaaga taaagctgca gaaatgaaag 1609921 aaatggacga tatttcgatt aagcagttta tgattcaagg ccattaggag cgaatgtaat 1609981 gtccggcaaa aagaaagaat caggtaagtt ccgttcggtt ttgcttatca ttatcctccc 1610041 gctgatgttt ctattaatcg caggggggat tgttctttgg gctgctggta tcaatgtctt 1610101 aaagccgata caggatgctg cggcaaaaac gccggttctt aaagaattgg tccctgaaac 1610161 cgaaaataaa aaaggcgcag catcaagtaa ggatagcagt aatacggcag ctctggaaaa 1610221 gaccattaag gatcaaaaaa gtgaaatcag tatattgaat aaagatttag aaacaagtaa 1610281 atcagaaatc gacaggctca atcaaaagat ccgttcactt gaaaagacgg ctgaggatca 1610341 aaaaaagtca tcagaagatc atactgaagg atcagcagac tcgaaagctt cttctgaaaa 1610401 tgacaaagtg atcagtgtgt acaaaagcat ggacagcgga aaggctgcta aaattattgc 1610461 ccaattaaag gagcaagaag cactgaaaat attgaatggc ctaagcaaaa agcagcttgc 1610521 tgacatattg gcgaaaatga ctcctgagca agcagcaacc tatacagaaa aaattgctgc 1610581 cagccaagaa tagggggaat gaaaggtgaa gctgcttgaa ttagccggac ctttgctgca 1610641 aaccacaacg ggttctgccg ctaaaaacat gaaaagtagc cagggagttt ttcaaaactg 1610701 gcttatgtct gaggctggat tgaaggaact ttcagaacaa ggaaagggaa ctcctaattc 1610761 tgaagatcag cttttagcag atgcgcttaa aaagatcggt gaatggctaa atgcaagtcc 1610821 tgaagatcaa gacaaacaaa atgcggatct tttgcaaaca ttaagcaaac tgacagggaa 1610881 gcaattggat gcgaatgctc tgcaaatgtt gcaaaatctt ttgcaagcag ttgaatcaaa 1610941 aatgtcaggc gggacggatc aattgctcac agaaacggag aaaatctttt cagaagctaa 1611001 aacggctctg agtgccaatg attctgcttc tgacattaat ggagcactga agtctgataa 1611061 agagcaatca aatcaggaaa atgaagtatc cgagcctgca aaagagctta tctatatcca 1611121 gatgttcatt agccagctcg tagaagggaa taagctgact gatctcggga atggcaatga 1611181 agctcatgcc atttaccaaa atggagatca attcctttct gcattagaaa agaagggtgt 1611241 atctcaacaa ctaattcagg atcttaaaca gcaaatattc actaaagctg agtcaagttc 1611301 aaaactttac tcgatgacag cgtcagagct gaaaagtttt caaagcttaa tggatcaaat 1611361 gtctatgctt cctcaaaaag ggaccaaaga atggagttta gctgaaagcc agctgaaagc 1611421 cttcttgtta tcgaaatcat ccgaatcatc acaagacttt gggaagagtg ttctcacacc 1611481 gctctcgcag agttcatcca gcaaaaatgc atcggatgtt tctggaagta ttcagcctgt 1611541 agatagtaaa tcaggactcc aaatgctgtt ttcggggtat cggggcatag gaggagttca 1611601 aacacttgat ctgcagcaga tgtcatctga tataccaaat gccgaaacaa aaacggtggc 1611661 tgatcaagtg attaatgcgt ggaagcagat gaaatatacg cctttcggca gatcgacggg 1611721 aagtttcact attcggctga accctgaaca tttaggattt gtcacaatca agctgacaaa 1611781 tgaaaatgga atgtttcaga gtaaaatcat agcatctagc caatcagcaa aagaattgct 1611841 tgaacagcat cttcctcagc tgaagcaatc attgccgaat atggccgtcc aaattgaccg 1611901 ttttactctt ccggtccaaa gcggggatca gccgatatac ggccagcttg ctgatgaaca 1611961 gaaacagcag caagaggggc agagacagca aagacagaaa aagcaatcaa atgattttgg 1612021 cgatctgctc gatgaagtgt cgatggttga aatggaggaa gaagaatgac ttctataagt 1612081 tcagaatata aactgcctga aaaaacgaac actgtgtcga cgaacaacag cagcttgggg 1612141 aaagacgagt ttttaaaaat attaatgact caagttcaaa accaagatcc gcttaacccg 1612201 attgacgata aagaatttat cagccagatg gcgacttttt caagcttgga gcaaatgatg 1612261 aatctgaata cgacaatgac tcaattcgtt gaaaaccaag atccgtttac aacgtatgtt 1612321 gattggatgg gaaaagaagt atcttggact gatggtaaaa gtgcaacaga taaaacaggc 1612381 acagtaagct ctgttaaaca ttttaaagga aattattatc tcgttcttga tgatgggacc 1612441 gagatcagtc ctgcgaatgt catgtctgtg ggacaatcat ctaaataaaa acatctgggg 1612501 gaatatatta tgttacgttc actttattct ggaatcagcg gtatgaaaaa ctttcaaaca 1612561 aagcttgacg taatcggtaa caacattgcc aacgtaaata cagtaggatt caaaaagagc 1612621 cgtgtgacct ttaaagatat ggtaagccaa acgattgccg gcggttctgc tgctggtgca 1612681 acaatcggcg gaacaaactc taagcaaatc ggtttaggtt catcatctgg cacaattgat 1612741 acaattcatt caacaagcgc gacacaaagc acaggaagaa cacttgattt agcaattgac 1612801 ggcgacggtt acttccgaat tgatacaggt gacgggacag cttatacaag agcagggaac 1612861 ttctatttag ataatactgg aacactggtt acaggtgatg gctaccatgt actaaatatg 1612921 aatggcggaa caattaaaat tcctactgat gctcaaagct ttagcattgg ttctgatgga 1612981 aaggtgtcaa ttgttgatgc tgaggggaaa acacaagacg ggggacaaat cgggattgtt 1613041 acttttgcca acagtgatgg attggataaa atcggaagca acctataccg tgaatcttta 1613101 aactctggaa cggccagtgc agcgaaccag cctggtgacg gcggaactgg tgctcttaaa 1613161 tcaggatttc tcgaaatgtc taacgtcgat ttaactgacg aatttactga aatgatcgta 1613221 gcccagcgcg gattccaatc aaactcaaaa attattacaa catctgatga aatccttcaa 1613281 gaactggtta accttaaacg ttaaggaggg aggggaggcg agtaatcgct tctccgctgt 1613341 tttatgatta aagtaacccg tttgaacggg cagcccttta cactgaatgc gctatttatt 1613401 gaacagattg aatgttttcc ggatactaca attactctgt caaatggtaa gaagtttgta 1613461 gtaaaagaag atgaagaagc tgttctggaa aagatcgcag ctttctaccg aaaaatacaa 1613521 atatttgcaa tggatcaagg aatagaggaa ccggaatgaa gaaaaagtta atgatcatat 1613581 tactaattat tcttatcgta attggtgctc tcggggcggc ggcttatttt gttttaggcg 1613641 gaaagtccga aaaaagtgaa gcgaaaaaaa gtattgatga aatcgttgcg tcttctgttg 1613701 atgtagaaga gatcacaaca aatttaaagt ctgataacat tatccgtctt gctattaaac 1613761 ttgaaactga ttctgataaa tcaaaagaag aacttgagaa acgtgatttc caagtgaaag 1613821 acgctgttat atcactgctg gctgatacga atgctgatca gattgaggga gacaagggaa 1613881 aagaaacctt taagaaggaa ctaaaagata aaataaatag ctacctccaa gaaggaaaag 1613941 tagaaaaagt gtatattacc tcctttaatc tgcaataaag cataatttga cagaatacgg 1614001 aggtgaggaa aatgtcagga gaagttctct cccaaaatga aatagatgca ctgctctctg 1614061 caatatcaac tggtgaaatg gacgctgaag agctgaaaaa agaagaaaaa gagaagaaag 1614121 tcaaggttta tgatttcaaa cgtgcgctgc ggttttctaa ggatcagatc cgcagtttaa 1614181 cgagaattca tgacaatttt gcaagacttc ttaccactca tttttctgct cagctcagaa 1614241 cctatattca catatctgtc agttctgttg atcaggttcc gtatgaggaa tttatcagat 1614301 cgattccaaa catgacgatt ctgaatctat ttgatgttca tccgatggaa ggaagaatta 1614361 tgatggaggt caaccccacg atagcttata cgatgatgga tcgagtcatg ggcgggattg 1614421 gaatcagtca taacaaggtt gacagtttga cagaaattga aacaaaaatc atttctaatt 1614481 tatttgaaaa tgcactgggt aattataaag aagcttggca gtcaattgct gatattgaac 1614541 cggaaatgac tgagtttgaa gtgaatccgc aatttgttca gatggtatct cctaatgaaa 1614601 cagtcgtggt gatctcgctc aatactcaaa ttggtgaaat cagcggtgtc attaatctct 1614661 gtatcccgca tattgtactc gagccgctca taccgaagct ttcagtccac tattggatgc 1614721 aatcagaccg aaatgagcca aagcctgagg aaacaaagtc gcttgaaaaa cgtatcatga 1614781 cagcacaaat acctgtcgtg gccgagctcg gcacatctga actgacgata gaagagtttt 1614841 taagtttaga agtcggagac tgcataactt tggacaaatc agtcacggat cctcttactg 1614901 tattggtcgg agataagccg aaatttttag gacaagccgg ccgggtgaat cgaaaacagg 1614961 cagtgcaaat tttagatcac gacataagag gtgaacaaga tggagaataa tagattatct 1615021 caagatgaga ttgacgcgct tcttaacggt actggcagca cgcttgatga gccagagatt 1615081 ccggaagtag atgacttatc ggaaatggag cgtgatgcga tcggtgaaat cggtaatatt 1615141 tcattcggca gttctgcgac agcactgtca acgcttttaa atcaaaaggt cgatattacg 1615201 actccaagcg taacggtcat tccaagaagt aaaatcagcg atgcgtttcc tgaaccgtat 1615261 gtagcgattg aagtgaatta tacggagggc ttcagcggaa gcaacctgtt agtcgtggaa 1615321 caaagtgacg cggcgatcat tgcggactta atgatcgggg gagacggaaa aggtgcggac 1615381 ccttcactgg gtgaaatcca tttaagtgcg gttcaagaag caatgaacca aatgatggga 1615441 tcggctgcca catcaatgtc tactgtattc agtaaaaaaa ttgatatttc acctcctcgg 1615501 gttgaattgc tggatgttac tgaagaaaag ggtacagacc gtattcctga tgatgaaatg 1615561 ctggtgaaag tttctttcaa cttaaaggtg ggagaattaa tagactccag cattatgcaa 1615621 ctttacccat tgacatttgc gaaagattta atttcaagcc ttatgaactc agaaagtgca 1615681 gaggaagaag aaacggtgca gcctgaagtt acatacgaac agccgaaaga gcctgtgacg 1615741 ccagagccgc gtattgaacc gaagcaacag cagcagccgc caaaaaggca gggaacagca 1615801 aaaaaagcag cgccagttca ggtttcaccg gtggaatttt ccgcgtttga tccaaacgaa 1615861 gctgtacaag cccctattca taatctggat atgcttttgg atatcccgct ttcgattact 1615921 gttgagcttg gcagaacgaa gagaagcgta aaagagattt tagagctttc tgccggaagt 1615981 attatcgagc ttgataaatt agccggtgag cctgtagata ttttagttaa tcagcgtatc 1616041 gttgccaaag gcgaggtcgt tgtcattgaa gaaaacttcg gagtgagagt cactgacatt 1616101 ttaagccagg cagagcgcat taataattta aaataacgaa acacaaggag agagatagat 1616161 tatggcacat agaattttaa ttgtagatga cgcagcattt atgcgaatga tgattaaaga 1616221 tattttggtt aaaaatggtt ttgaagttgt ggcggaagct gaaaatggag cacaagcggt 1616281 agagaaatat aaagagcatt cacctgacct tgttactatg gatatcacga tgccagaaat 1616341 ggatggtatt acagcattaa aagaaattaa acaaattgat gcgcaggcaa gaatcatcat 1616401 gtgttctgct atgggacagc aatcaatggt tattgatgcc attcaggccg gcgctaagga 1616461 tttcattgtg aaacctttcc aggctgaccg tgtgcttgaa gcaatcaaca aaacattaaa 1616521 ttaaagggtg tacgactgtt gaaaaagagt caatatttta ttgtttttat ttgttttttc 1616581 gttttattca gtgtacatcc gattgctgct gccgcggcag actctgataa ttcaactgta 1616641 aacgaatggt ttcaaaagaa agatgaaaaa actgcagatc aatcagagca aaagaaagaa 1616701 aaaacaacaa aaactgctga tgagacggag ggagcggctg ctccttctgt ctcagctttt 1616761 gattttgtaa agatgatttt cgctttactg tttgttatcg tgctgattta cgggctggtt 1616821 aagctcatga acaaaagaaa tcggctccta aagccttttc aatatgttga aaatattggc 1616881 ggcacatcgg tcggtcagaa cagatccata caattgatca aggtcgggaa aagtgtgctc 1616941 gtcgtcggtg taggagagac gatccagctg ctgaaagaaa ttgaggatga aaaagagatt 1617001 gaagtcattc tcagtcagca tgaagaggca atgtcaagca aaatagagtg gcaaaagttt 1617061 gtgaagccgc ttaagagttc tgaacatcag ccgcagcaaa aactgccttc attttcaaaa 1617121 gcattaaaag agcaacttga agagttaaaa caaaaccgtt ctgaaggaaa gaagaaaggc 1617181 ccacgtcatc atgaatgagt ttataaatat tttcagttca agcgatccgg aaaacgtaag 1617241 ttcgactgtt aaattactat tattgttaac tgtattttca gtggcgcctg gaatattgat 1617301 tcttatgact tgttttactc gcatcgtcat tgttctgtca tttgtcagaa cttcacttgc 1617361 gacgcaatct atgcccccaa accaggttct aatcgggctt gcgctgtttt taacattttt 1617421 tattatggct cctacttttt cagaaattaa taaagaagcg ctgaccccat taatggacaa 1617481 caaaatcagc ttggatgaag cgtatacgaa agctgaggaa ccgattaaag aatttatgag 1617541 taaacacaca aggcagaagg atctggcgct gtttatgaat tacgcgaaaa tggataaacc 1617601 tgaatcatta aaggatattc cgttaacaac aatggttccg gcttttgcca tatcggagct 1617661 taaaacagca tttcaaatag gttttatgat ttttatccct tttttaatta tagatatggt 1617721 agtggcgagc gtcttgatgt caatgggaat gatgatgctg cctccagtta tgatttctct 1617781 gccctttaaa atattacttt ttgttttggt agacggctgg tatttaattg tgaaatcttt 1617841 gcttcagagc ttttagggta ggtgctaaac gtgagttcag aatttgtaat ttctatggcg 1617901 gaaaaagccg tatacgtaac gctgatgatc agcgggccat tattggctat tgctttactg 1617961 gtcggtttaa ttgtcagcat atttcaggcg acaactcaaa tccaggaaca gactttggcg 1618021 tttattccga aaatcgtggc ggttctcctg gctctcattt tttttggtcc gtggatgctg 1618081 tcgacgattc tttcatttac aacagagctg ttttctaatt taaatcgttt tgcagggtaa 1618141 tgtagagatg aattcaatta ttgacttatt tcctgctttt ttattggttt ttattagaat 1618201 ctctgctttt tttgtaacga ttccgctatt tggacatcga aatgtgccag ctgttcatcg 1618261 cataggtttt gctttttttc ttgcggtcat ttgtttcagc accattgata aaccgccctc 1618321 tttggagata gatgagcact atatgctttt ggcgtttaaa gaagctttgg tcggcctatg 1618381 tctgggttta attgcttata tgatgattgc cgcagtgcag attgccggct cgtttattga 1618441 ttttcaaatg ggattttcaa tagcaaacgt tattgatccg caaaccggtg cacaaagtcc 1618501 gttgattggc cagtttatct atacgatggc acttttgttt atgctgagtg tcaatgccca 1618561 ccatttgttg ctggatggta tttactacag ctttcagtat atttcagttg atcaggcatt 1618621 tccgaatttc ggcgatgaaa agtttgccta ttttattgcg aaaagcttta atgcaatgtt 1618681 tattatcgct tttcaaatgt cagcgccggt tgtggccagt ttgtttctag ttgatttagc 1618741 attaggtatc gtggctcgaa ctgttccgca gttaaatgta tttgtggtcg gtctgccttt 1618801 aaagatcgct gtcagtttca ttatgctcat tgtatgtatg tccgttatct tcgtcgttgt 1618861 ccggaatgtt ttcagtttaa cgattgaaac gatgcggaat cttttagcat tggtcggtgt 1618921 ttcttaatga agcttagagt tgacctgcag ttttttgcgg gagagaagac agaaaaagcc 1618981 actccgaaaa aacggaagga tacgcgaaaa aaagggcagg tagccaaaag ctcggatgtc 1619041 aataccgccg tttctttact ggtaatattc ctttcgctta ttgcaattgg tccgtatatg 1619101 agagacaggc tgctgtcatt catagaaaca ttttataccg aatcgctcac aatgaagctc 1619161 tcagaatcaa atgtgcatac attgtttgtc agcttattaa aggatatggg catgatactc 1619221 gcaccgatct tgcttgttgc tcttgttgca ggagtcgtaa gcaactatat gcaggttggg 1619281 ttcttgtttt ctgctgaagt gatacagcct aagcttgaaa aactggatcc gatcaaaggc 1619341 tttaaacgaa tatacagtat gagggcgatt gtagagctga ttaaatcaat tttgaaaatc 1619401 gtagtcgtcg gttttgcggc ttttgctgtg ctttggctgc attatggaga aattctccgg 1619461 cttcctctcc tgacacccga agaggcactt tctttcgttt caaaactcac tttgtggatg 1619521 ggactaagcg gtgcaggtgc attgttgatt cttgctggtc tcgactattt atatcagaga 1619581 tttgactatg agaaaaatat caaaatgtca aaacaagata taaaagatga gtacaaaaaa 1619641 tctgaaggag acccgattat caagtctaaa attaaacaaa gacagcggga aatggcgatg 1619701 aggcggatga tgcaggaagt tccaaaagca gatgtcatta tcacaaaccc gactcactat 1619761 gcgattgctt tgaaatatga tgaagaaaaa atggacgcac cttatattgt tgcaaaaggc 1619821 gtcgaccacc ttgcgttaaa aatcaggaaa attgctaaag agcatgatgt catgatggta 1619881 gaaaacagac cgcttgcccg tgcgttatat gatcaagtgg aaattgacca ggcagtgccg 1619941 gaagaatttt ttaaagtttt agcagaaatt ctggcttacg tatataaaac aaaacaaaaa 1620001 gtatattgaa tttttcgatt taaaaggaga gaaaaaacag catgtcaaca agagatttat 1620061 ccgttttaat aagtgttgtc ctcattgtgg cgatgctggt gattccattt cctccatggc 1620121 tgttaagtat tttgatcatt attaatattt ctcttgcgtt gatcgtgctt ctcaccacaa 1620181 tgaatatgca ggaagcgctt cagttttcga tttttccgtc actgttgctg cttttgaccc 1620241 tatttcgttt gggcttgaac gtctcaacta cccgttcaat tctttcacac ggtgagggag 1620301 gtaaagtcgt cgagactttc ggaaatttcg ttgtcggcgg aaatgtatta gttggactcg 1620361 ttgtatttat catccttatt attattcagt ttatcgtcat tacaaaaggt gctgaacgtg 1620421 tttccgaggt tgcagcaagg tttacgctgg acgcaatgcc ggggaagcag atgagtattg 1620481 atgctgattt aaacgcaggg atgattaccg aacaggaagc gaagcatcgc cgcgaaaaag 1620541 tggcaagaga agcagacttt tatggagcaa tggacggtgc cagtaaattt gtaaaaggtg 1620601 acgccattgc cggaatcatc attgtgatga tcaatattat tttcggaatc gtgatcggaa 1620661 tgcttcagca gggcatgtcc attcaagaag ctgcttcaca ctttacgatg ctgactgtag 1620721 gggatggaat tgtttcgcaa atcccggcac tgttaatttc tacggctacg ggtattgtgg 1620781 tcacaagagc tgcatctgaa ggaaacttag ggcatgacat tacaggccag ctgtttgcgt 1620841 atccaaagct tttatacgtc gcagcagcta cgatcatgct tttaggtatt ttcactccga 1620901 tcggcatcct tctgacgggg ccgcttgcgg gattgcttgc ttttggcgca tatacactat 1620961 ctaaatcagg taaggaaaaa gaagaagtgg atgagattct tgaggaagag gctgaggtgg 1621021 acgagcttaa aagccctgaa agtgttgttc agcttctgca tatagatccg atagaatttg 1621081 agtttggata tggcctgata ccgcttgctg atgccaatca aggcggtgat ttattagacc 1621141 gaattgttat gatacgccgt cagttggctt tggaactcgg gcttgtcatt cctgtcgtgc 1621201 gaatcagaga taatatagcg ttgcagccta atgaataccg attgaaaatt aaaggaaacg 1621261 aagtagcaaa aggcgagctg ttgcttgatc attatttagc gatgtcgcct actcctgagg 1621321 acgatctcat tgaagggatt gaaacagtgg agccttcatt cggactgccg gctaaatgga 1621381 ttagcgaagc ggtaaaggat gaagccgaca tgcttggtta tacagtagtt gatcctgcat 1621441 cagtcgtttc aacgcatatt acggagaaaa ttaagcagca tgcccacgaa ttgatcggaa 1621501 ggcaggagac aaaacagctg atcgatcact tgaaagaatc gtatccagtc ctggttgaag 1621561 aggttacgcc gaatccattg tctgtcggtg atattcagaa agtgcttgct aagcttttaa 1621621 aagaaaaagt ttcaattcga aacttagtaa cgatttttga aacacttgct gactatggga 1621681 aattaacaac agattctgat ctcttgacag agtatacaag acaagcgctt gctaaacaaa 1621741 ttacagccca gtttgccaaa gaaaatgaag tgttgaaggt tgttacttgt tccggccgtg 1621801 tagaaaaagc aatagcagac ggtgtgcagc agacggaaca cgggaactat ttatcacttg 1621861 aaccagatat ttcagaaagt atagtgcgct ctgtcgccaa agaagctgaa cagctctcat 1621921 tacgtcagga aaccgcgatt cttctttgct cgccgcctgt cagaatgtat gtgaagcagc 1621981 tactggaacg gtacttccct gatcttccgg tactctctta taacgaactt gaggcgaatg 1622041 ttgaggtaca aagcattgga gtggtggata tttaatgaaa ataaaaaaat ttactgctgc 1622101 ttcaatgcaa gaagcggcac ttctcatcag aaaagagtta ggtaatgaag cggtcatatt 1622161 aaattcgaaa aaaattaaaa agcgaaaatg gtttggcctc gtcaacaagc ctgctgttga 1622221 agtaatcgcc gtattggatc aggactttct tgagaaaaaa acgcctcaga aggcagctga 1622281 accgaaacaa acattaaaaa ctccggtcag cagtccaaaa atagaggaga gaacatatcc 1622341 ccctcaaatt ccggcgcaac aggagctagg tgatttttca gcatatcaat ctgtacttcc 1622401 tgagccgctg cgaaaagcag aaaagctttt gcaagaaaca gggatcaaag agtctacgaa 1622461 aacgaacact ctgaaaaaat tgcttcgctt ctctgttgaa gcaggcggct tgactgaaga 1622521 aaatgttgtc ggcaaacttc aggaaatact atgcgatatg ctgccctcag cagacaagtg 1622581 gcaggagcca attcattcaa aatatatcgt tctctttggt tcaacagggg ctggtaaaac 1622641 aactacactg gctaaactcg cagccatatc tatgcttgaa aaacataaaa aaatcgcttt 1622701 tattacaaca gatacgtatc gtattgcagc tgttgaacag ttgaaaacat acgctgaact 1622761 gctgcaggct cctctggaag tttgctatac aaaagaagaa tttcagcagg cgaaggagct 1622821 attttctgag tatgatcatg tgtttgttga tacagctgga agaaacttca aagacccgca 1622881 atacattgat gaactgaaag aaacgattcc ttttgagagc agcattcagt catttcttgt 1622941 tttatccgcg actgcaaaat atgaagatat gaagcatatt gtcaaacggt tttcatccgt 1623001 ccctgtcaat cagtatattt ttacgaaaat agatgaaacg acttccttag gttctgtatt 1623061 taatatactg gcagaatcaa aaataggtgt cgggtttatg actaacggcc agaatgtgcc 1623121 tgaggatata cagactgtat ctccacttgg ttttgtgagg atgctgtgca gatgaacaga 1623181 tatgaccaag cagcaacttt acgggcgaaa atggaaaaac gtgagcgcgt tctgccaatg 1623241 gtttattcac aaaaagcgaa gacacttgct gtcatcagcg gcaagggcgg tgtcggaaaa 1623301 tccaatatta ccttaaatat ggcacttgcg ctgcaggata aaggtaagaa ggtgctgctc 1623361 atcgaccttg atatcgggat ggggaacatt gatatattaa taggaaattc atcgtctgcc 1623421 acgataatcg atgttttaac cgatcgtaag cctttgctgc agtcattatc cgttggccca 1623481 aagggtttgc ggtatatatc agggggaacc ggtcttgatg tgatgtttca gctcgatcag 1623541 agaaaatgga cgttttttgc caatgaactt tctcatgcat taagccagtt cgattatgtg 1623601 ctgtttgaca tgggagcagg cttatcaaaa gatcaactgc cttttatttt atcagcagaa 1623661 gatattttga ttattacaac tcccgagccg acggccatta tggacgcata cagcgctgtc 1623721 aagcacttgg ttttgacaga aaataagctt tcaatgaagg tggctgtcaa tcggtgccgt 1623781 gaccaaaagg aagggcttga cgcttttgcc cgcctctccc gtacaattca tatgtttttg 1623841 gatgttcagg ttcagtttgc cggttccgtt tctgacgatg tgatcgtgag caaagcggtt 1623901 gtcgaacagg ttcctttttt cataaaaagc cctcaggcaa aagccagccg gtcagtccgt 1623961 attttagcgg acgccttgtt tgaaagagaa gaaacgagac acaaagaaga caaacagaca 1624021 tttattgaga aattatcttc ttttttaatg aggagggctt aatttgattc gtgtgcttgt 1624081 agttgatgat tcagctttta tgagaaaaat gataagtgat tttctgaccg aagaaaagca 1624141 gatagaagta atcggaactg cgagaaacgg agaagaagcg cttaagaaga ttgaattatt 1624201 aaaaccggat gttattactc ttgatgttga aatgccggtc atgaatggga cagatacgct 1624261 ccgcaaaatt attgagattt ataacttgcc ggtcattatg gtgtctagcc agaccgagaa 1624321 aggtaaagaa tgcacaatta attgtttgga gatcggtgcc tttgacttta tcacaaagcc 1624381 atcaggctca atatctctgg atctatacaa aattaaagaa caactagttg agcgtgtcgt 1624441 cgcggcagga ctttccggca agcggaaacg tcctgtttcc cagacagttc ggcccgaacc 1624501 tattgtgcgt gctgtcgtta agcctgaatt aagcaaaccg aaacctggca cgggcagaca 1624561 aattgtgtgt atcggcacat caacaggcgg tccacgggcg ttacaaaagg tgataccgaa 1624621 gctccctaag gatttgaacg caccagtggt tgtcgttcag cacatgcctg aagggtttac 1624681 tgcttctttg gctgatcggc tgaatcattt atctgacatt caggtaaaag aagcaaaaga 1624741 tggtgaagca gctcttaacg gctgtgttta catagcaccg ggcggaaaaa acatatccgt 1624801 tattaaaaac agcgaaggac tccaggttgt gcttgataac catgacacac caagccgtca 1624861 taaaccatct gctgattatt tattccgttc tgtcgggaaa ctgacagatt atgaaaaagt 1624921 agcggttatc atgaccggaa tgggcagtga cggcactgct ggactaaagg acatgctaac 1624981 agccggcaat gtgaaagcca ttgcggagtc tgaagaatct tgtgtcgtat acgggatgcc 1625041 aaaagctgct gttaaagcgg gtctcattca tgagattaaa catgtggaag atatcgcagc 1625101 atccatcaca agctgtgtga aaaaagagag ggtgtgattc aaatggatat gaatcagtat 1625161 ttagatgtct ttattgatga gagtaaagaa catttacaaa catgtaatga aaagcttctt 1625221 cttttagaga aagacccgac tgatcttcag ctcgtacatg atatattcag ggctgcccat 1625281 acattaaaag gaatgagcgc aacgatgggc tacacggatt tagcacatct tacccatctg 1625341 cttgaaaacg tgctggatgc aatccgaaac ggagacatgg aagtcacctc agactggctg 1625401 gatattttgt ttgaagctct ggatcacctg gaaacaatgg ttcagtctat tattgatggc 1625461 ggggatggta aaagagatat ctcagaagtg agtgccaagc ttgatgtgaa tggtgcgcac 1625521 gctgaatccg ctgcctccgc tgaacctgca gaagcacaga gttcagcatc tgattgggaa 1625581 tatgatgaat ttgaacgcac agttatacaa gaagcggagg agcaaggctt caaacgatat 1625641 gaaatcaaga tttctctgaa cgaaaactgt atgttaaaag cagttcgtgt ctatatggtg 1625701 tttgaaaaac taaatgaagt cggagaagta gccaaaacaa ttccaagtgc tgaagtgctt 1625761 gaaacagaag attttggaac tgactttcaa gtttgtttct taacacatca atcagcggaa 1625821 gacattgaac aattaatcaa tggcgtgtcg gaaattgagc atgttgaagt cattcaaggg 1625881 gctcctttaa catcagctga aaagcctgaa gaatctaagc aagaagattc accagcagca 1625941 gctgtacctg cgaagcagga gaaacaaaaa cagcctgcta aaaacgatga acaggcgaag 1626001 cattcagccg gcggatctaa aacaattcgt gtcaacattg acaggcttga ttctttaatg 1626061 aacttatttg aagagcttgt cattgaccgc gggcgtctcg agcagattgc gaaagagctt 1626121 gagcataatg aactgactga aacggttgaa cgaatgacga gaatttccgg agatttgcaa 1626181 tcgattattc tgaatatgag aatggtcccg gttgaaactg tttttaacag attcccgaga 1626241 atgattcgcc agcttcagaa agagctgaat aaaaaaattg aactctcgat catcggtgcg 1626301 gaaactgaac tggatcgtac agtaattgat gaaatcggag atccactcgt tcacttgatc 1626361 agaaacagta ttgaccatgg tatcgaggcg ccggaaacac gtttgcaaaa gggaaaaccg 1626421 gaatcaggaa aagttgtgct taaagcttat cacagcggca accatgtctt tatcgaagta 1626481 gaggatgacg gcgcaggcct taatcgaaaa aaaattctgg aaaaagcgct tgagcgcggg 1626541 gtcataacgg aaaaagaagc tgaaacctta gaagacaacc aaatttacga attgattttt 1626601 gctccggggt tctcaactgc tgaccaaatt tctgatattt ccggccgcgg tgtaggactt 1626661 gacgttgtaa aaaacaaact ggagtctctt ggcggttcag tcagtgtgaa atcagccgag 1626721 ggtcaaggct ctctattcag catccagctg ccgcttacct tgtctattat ttcagttctg 1626781 ctgattaagt tggaagaaga gacatttgcc attccgattt cttcaatcat tgagacagca 1626841 gttattgaca gaaaagacat tttgcaaacg catgaccgtg aagtgattga ctttagaggg 1626901 catattgtcc ctgtcgttta tttaaaagaa gagtttaaaa tagaagatac aagaaaagat 1626961 gcggaacagc tccatatcat tgtcgtgaaa aaaggcgaca aacctactgc atttgtggtg 1627021 gactccttta ttggccagca ggaagttgtg ctgaaatcac tcggagatta tttaacaaac 1627081 gtctttgcaa tttccggagc tactatttta ggagacggag aagtagcgct cattattgat 1627141 tgtaatgcac tgattattta accattcgag gaggtgtctc acatgactgc agaaattaaa 1627201 acaggcgaaa aaatgatagt ctttatggta aatggcaaag aatatgccat ttccgtcact 1627261 caggtgaaat caattgaaaa atggcaaaag ccaacgaggg tacctggcgt cgaaccatat 1627321 atttgcgggg taatcaattt acgcggggtg gtgactccgg ttattgattt aagaaaacgc 1627381 ctgaatttgc cagagtatga aattacagat gaaacacgaa ttatcattat tgcttatcgt 1627441 gatattgaag tcggctggat tgtggatgaa gcgaatgatg tgattaccgt acacgaaagt 1627501 gaaatagaat ctgctccaga aggcgttcag aaagatacgg atgtgtcgat cgaacagatt 1627561 gtgaaacaag agaacagact cttaaatatt attgatgcga acgcggtttt ggataaagaa 1627621 tcatctcagt ccgctgtgcc cgatcaagct taatcttaaa ggggttatga catgagtatt 1627681 tttaatggaa tcaaagaaga gcagatggac attttgcggg aagtcggcaa tataggcgcc 1627741 ggccactccg cctctgcaat ggcccagctg ttaaatagaa agatagatat ggaagtccca 1627801 tttgcaaagc tgctgtcttt tgatgagctt gttgattttt tcggcggcgc cgatgtcccg 1627861 gttgccagca tctttttaag aatggaaggc gatttaacgg gttcaatgtt ctttataatg 1627921 cctttttttc aggcggagca gtttatcaga gagctgattg gaaaccccga ttttgacata 1627981 gaggacttag gtgaagacca catgagctca tccgctttgc atgaactggg caatatttta 1628041 gcggggtcat atttaacagc tttggcggat ttgacgaaac tccagctcta tccaagtgtt 1628101 cctgaagtct cattggacat gttcggagct gtgatcagcg aagggctgat ggagctcagt 1628161 caggttggag aacacgccat tgttgtcgac acgtcaattt ttgaccaaag ccatcagcag 1628221 gagctgaaag cgcatatgtt tatgctgccg gactatgatt catttgaaaa gctctttgtc 1628281 gccttaggtg catcattatg agtacaactg aggctgttgt tataaaggtt gggattgctg 1628341 acgtgaagat cgcccgcttc ccggatacca tccggacctc tggtttgggc tcatgtgtgg 1628401 ggctggtgct ttatgataaa gaaaagcaaa cggcgggtct tgttcatgtc atgcttccgg 1628461 attcgacgtt atcgaaaact gccgagctca accgggctaa gtacgctgac accgccgtac 1628521 agaccacgat tgatatgctg atagaagcgg gatgccggaa atttgcatta aaagcaaagc 1628581 tggccggcgg atcagagatg tttaaattta aatcgacaaa tgatttgatg aagatcggac 1628641 cgagaaatgt attagcgata aaagaacagc tgtctttatt taatattcct attattagtg 1628701 aagatacggg cggctcaagc ggccggacga tagaatttga accgaagtcc tgcatgctgc 1628761 atattcgaac tgttaaacaa ggtgaaaaaa cgatttaatt aaggtattag ggggataaca 1628821 atgcaatcct tgaattatga agatcaggtg ctttggacgc gctggaaaga gtggaaagat 1628881 cctaaagccg gtgacgactt aatgcgccgt tacatgccgc ttgtcacata tcatgtaggc 1628941 agaatttctg tcggactgcc gaaatcagtg cataaagacg atcttatgag ccttggtatg 1629001 cttggtttat atgatgccct tgaaaaattt gaccccagcc gggacttaaa atttgatacc 1629061 tacgcctcgt ttagaattcg cggcgcaatc atagacgggc ttcgtaaaga agattggctg 1629121 cccagaacct cgcgcgaaaa aacaaaaaag gttgaagcag caattgaaaa gcttgaacag 1629181 cggtatcttc ggaatgtatc gcccgcggaa attgcagagg aactcggaat gacggtacag 1629241 gatgtcgtgt caacaatgaa tgaaggtttt tttgcaaatc tgctgtcaat tgatgaaaag 1629301 ctccatgatc aagatgacgg ggaaaacatt caagtcatga tcagagatga caaaaatgtt 1629361 ccgcctgaag aaaagattat gaaggatgaa ctgattgcac agcttgcgga aaaaattcac 1629421 gaactctctg aaaaagaaca gctggttgtc agtttgttct acaaagagga gttgacactg 1629481 acagaaatcg gacaagtatt aaatctttct acgtcccgca tatctcagat ccattcaaag 1629541 gcattattta aattaaagaa tctgctggaa aaagtgatac aataatgaat ttcatggtta 1629601 gcgagtgaaa aacatgtcaa cactattatg gcttttaagc tttatgctcc acggcgttct 1629661 tctgtacgct gtcattatcc tgtatacgag gctcgctgca gtgaaagaaa cagaaaaaca 1629721 gcaaaaacag atacttgaag agacggaaaa caccttggcg gcatttctgc ttgaattaaa 1629781 agaagaaaat gagaaactga tagaaaataa agcttcatct gcaagtcaat cagatgaaga 1629841 atcccaaaag tcaggccttc agacctctga aacatatcaa gagcgggatc cagtccaaga 1629901 ggcagagaat cttcctgaac atattgaagg tctgattaca gaggttgacc gtcgggaaga 1629961 gctcgtaaac agtgaggtcc aatcatttga agaccaggtc atagaattat atgaacaggg 1630021 atattcggca agtcaaattg cccagaaaat gaagagcgga aagacagaaa tcgagctatt 1630081 tttaaaattt cgctccaaag gtgtaaagga ttcttgattg tcggataaag ctgtgttata 1630141 ttatgtcttg gtgttaaata cacacgctta acgatttatg cagagggtgc tgcaggcggc 1630201 agttctgtac aaaaatgacc taagcggagg aaaaaaacca ttatattagg aggaaataac 1630261 atgtcagtca tttctatgaa gcaattgctt gaagctggtg ttcacttcgg tcaccaaaca 1630321 cgccgttgga acccaaaaat gaagcgttac attttcacgg agcgtaacgg aatctacatc 1630381 attgaccttc aaaaaacagt caaaaaagta gaggaagctt acaacttcac taaaaatctt 1630441 gctgctgaag gcggaaaaat ccttttcgtc ggaacaaaaa aacaagctca agattctgtt 1630501 aaagaagaag ctcaacgctc tggcatgtac tatgtcaacc aacgctggtt gggcggtaca 1630561 ttaacaaact tcgaaacaat ccaaaaacgt attaaacgtc ttaaagacat tgaaaaaatg 1630621 caagaaaacg gtacgtttga tgtacttcct aaaaaagaag tcgttcaatt gaaaaaagaa 1630681 ttagagcgtc ttgaaaaatt cctaggcgga attaaagata tgaaggatct tcctgatgca 1630741 ttattcatca tcgatcctcg caaagagcgc atcgctgttg cggaagctcg caaattaaac 1630801 atccctatca tcggtatcgt agatactaac tgtgatccag atgaaatcga tgttgttatc 1630861 ccagcgaacg atgacgctat ccgcgctgtt aaacttctaa cttctaaaat ggcagatgca 1630921 atcttagaag cgaagcaagg cgaagaagaa gcggaagttg ctgaagaaac tgcaccagaa 1630981 acagaaacaa caactgcgta acctattcaa aaggtgataa gagggactgc cttttatcac 1631041 cttttttcaa gaaaaatgtg taatatacat actcttgttt aaacatataa ggaggaatac 1631101 aaatggcaat tactgcacag caagtaaaag aactgcgtga aaaaactggc gcgggcatga 1631161 tggattgtaa aaaagcgtta actgaaactg acggagatat ggacaaagca attgaccttt 1631221 taagagaaaa aggaattgca aaagcagcga aaaaagctga ccgtatcgca gcagaaggtt 1631281 ctactcttat taaaactgac ggcaacaaag gcgttatcct agaagtaaac tctgaaactg 1631341 atttcgttgc gaaaaacgaa ggttttaaag agcttcttaa cactttagct gaccaccttc 1631401 ttgcaaacac gccagctgat gttgaagaag caatgggcca aaaaatggaa aatggctcaa 1631461 ctgttgaaga gtacatcaca agcgcagttg ctaaaatcgg tgagaaaatc actcttcgcc 1631521 gctttacagt tcttacaaaa gacgacagct ctgcattcgg tgcgtacctt cacatgggcg 1631581 gccgcatcgg tgtattaact gttctcaacg gtacaactga tgaagaaact gcgaaagata 1631641 tcgcaatgca cgttgctgca gttaaccctc gttacatttc tcgtgatcaa gtatctgaag 1631701 aagaaacaaa tcatgagcgt caaatcttaa ctcagcaagc cctccaagaa ggcaaacctg 1631761 aaaacatcgt agcgaaaatg gttgaaggcc gtctgaacaa attcttcgaa gaaatttgtc 1631821 tattagacca agcgttcgtt aaaaacccag atgaaaaagt gaaacaagtt attgcagcga 1631881 aaaacgctac tgttcaaact tttgtccgct atgaagttgg agaaggcatc gaaaaacgtc 1631941 aagaaaactt tgctgaagaa gtaatgaacc aagtgaaaaa ataatggtga aaagatttcg 1632001 cggctaagtc gcgtcttttc aggcagtata ggggacacat tttgtgttcc ctatttttaa 1632061 aactatattt acaaaccttt ttttctcttg cataatagaa aacggcaatg tttacacttg 1632121 gaggttatca tggaaaaacc aaaatacaaa cgtatcgtat taaagcttag cggggaagca 1632181 ttggcaggag aacagggaaa tggaattaac ccgactgtca ttcaatccat tgcaaagcaa 1632241 gtgaaggaaa tcgctgagct tgaagtcgaa gtggctgttg ttgtaggcgg cggcaactta 1632301 tggcgcggaa aaacaggaag tgacctgggc atggaccgcg cgactgctga ctatatggga 1632361 atgctggcga cagtaatgaa ttcgcttgct cttcaagaca gcttggaaac actcggaatc 1632421 cagtccagag tgcaaacatc cattgaaatg agacaagttg ctgaaccgta cataagaaga 1632481 aaagcgatac gccacttaga gaaaaaacgt gtcgttattt tcgctgcggg cacaggaaac 1632541 ccatatttct caactgatac gacagctgca ctgcgggctg ctgaaattga ggcagacgtt 1632601 attttaatgg ctaaaaataa cgttgacggt gtgtataatg ctgatcctag aaaagatgaa 1632661 tcagctgtta agtatgaatc actttcttat cttgacgttc ttaaagacgg cctggaagtc 1632721 atggattcaa cagcttcctc tttatgcatg gacaatgaca ttccgcttat cgtcttttct 1632781 attatggaag aaggaaatat caaacgtgcc gttatcggtg aatcaatcgg aacgatcgtg 1632841 agggggaaat aacgtgtcaa aagaagtatt aactcaaaca aaagaaaaaa tggaaaaagc 1632901 aattgctgct tatcagcgcg aattggctac tgtacgcgca ggccgtgcaa atccatcatt 1632961 attagataaa gtaacggttg aatattacgg agcgcagaca cctttaaatc agttgtcttc 1633021 tattaacgtg cctgaagctc gtatgctcgt tatcacgcca tacgataaaa cagcaatcgg 1633081 tgatatcgaa aaagcgattt taaaagctga tttaggtctt acaccaacaa gtgacggcaa 1633141 tatgattcga attgcaattc cggcactaac agaagagaga cggaaagaat tagtgaaagt 1633201 tgtaaaaaaa tatgctgaag aagcaaaagt agctgttcgt aacgttcgcc gtgatgctaa 1633261 cgatgatctc aaaaaacttg agaaaaacgg agacattact gaggatgaac tgcgtgcttc 1633321 cactgaagac gttcaaaaac tgacagatga atatgtgtca aaaattgaca gtgtcacaaa 1633381 agacaaagaa aaagaaatca tggaagttta atgaaaaact atgtacaata gataatagtg 1633441 aaaagaccct ctcatgttta cagggggttt ttttgttaat actgttgatt acattgatta 1633501 tcagcaggga atgtaacctt tttgggtgac ggaggaatct catgctcaac atactcaaaa 1633561 attggaagaa tcagcaaact gcggcttcca acttagaacg ttatacaaaa gaagacatac 1633621 ttaagggaga aattcccgaa cacatcgcca ttatcatgga tggaaatggc cgttgggcta 1633681 aaaaacgctc tcttcccaga attgcaggcc accatgaagg gatgaaggtg gtaaaaagga 1633741 ccacgaagct cgcaaacgaa ttaggtgtca aagtactgac attgtatgca ttttcaacag 1633801 aaaactggaa aagaccgaaa atggaggtcg attttttaat gaagcttccg gaagaatttt 1633861 tgaatacgta tcttccagag cttgttgagg aaaatgtaca ggttcggatc attggggatg 1633921 aaacggcttt gccggcgcac acattacgtg cgattgaaaa agctgtacag gacacggcgc 1633981 aaaacgacgg aatgatcctt aattttgctc ttaactatgg aggccgtact gaaattgtca 1634041 gtgctgcaaa atcactcgcg gaaaaagtga aggaaggctc tttgaatatt gaagacattg 1634101 atgaatcgct tttttctact tatttgatga ctgaatcttt gcaggatcct gaacttttaa 1634161 ttcgaacgag cggcgagata aggctgagta attttatgct atggcaggtt gcctacagtg 1634221 aatttgtctt tactgacgtc ttgtggcctg actttaaaga agatcacttc ttgcaggcgt 1634281 taggagagtt tcagcagaga ggccggaggt ttggcggaat ttagaggatg gtggacatga 1634341 aacaaagaat tttgacaggt gttctggcag caattgtatt tttatttttg gttattgtcg 1634401 ggaaattgcc gttcaccata ttaatttatg ctatgggcag tgtggcgctt tttgaacttt 1634461 tacggatgaa aaagctgaag ctggtttcac tgccgggttt gatcggtctt ttattattgt 1634521 ggatgttctt attaccaagc cagtattcgt tttttgaagc ggacgggatt tccaaaatgg 1634581 aaatcgcttt atttgcggta ctgctattgc tgacttacac agtgttggtc aagaacacct 1634641 ttacttttga tgaagtcggg tttattacgc ttgcagcaat ttacatcgga atgtgttttc 1634701 attattttat cgaaatcaga aatcttgacc aatacggatt aacatacatt ttttatgcgt 1634761 gtgttgtcat ttggtccacc gattccggtg cctattttgt cggtaaatcg cttgggaagc 1634821 ggaaactgtg gcctgaaatc agtccgaata aaacagtgga agggtttgca ggcggaattg 1634881 tcatcgcact tgtattggcg acgatttttc agcttgttgc acaacttccg atcccgtata 1634941 tctatctgct gttgatcacg ctgtttttgt ctgtttttgg acaactggga gatttagtgg 1635001 aatccgcctt gaaaagacat tacgatgtaa aggattctgg gaatattctt cccgggcatg 1635061 gcggtatatt agaccgtttt gacagtttct tgtttgtcat gcctttcttg tactttctgc 1635121 ttgccctttt ttcataaaaa agtctaatat gaatatgaga ctgatcatgc agcaataaga 1635181 ataggagtag tggcaacttt gaaaaatatt tgtcttttag gagcaacagg atcaatcggc 1635241 gaacagactc ttgatgtact gcgtgcacat caagaccaat ttcagctggt atctatgtcg 1635301 tttggcagaa atattgataa ggccgttcca atgattgagg tctttcagcc gaagtttgtc 1635361 tctgtcggtg atctggatac atatcataaa ttaaaacaaa tgtctttttc ttttgaatgc 1635421 caaatcgggc tgggagaaga aggactgata gaagcagcag tgatggagga ggttgacatt 1635481 gttgtcaacg ctttgcttgg aagcgtcggt cttatcccga cattaaaggc aattgaacag 1635541 aaaaaaacaa ttgcgcttgc aaataaggaa actcttgtca ctgcagggca tatagtaaaa 1635601 gaacatgcta agaaatatga tgttccgctg ctgcctgttg acagtgagca ttcagccatt 1635661 tttcaagctc ttcaaggcga acaggctaaa aacattgaac gcctcatcat tacggcatcc 1635721 ggcggaagtt ttcgggacaa gacgcgggag gagctcgaat cagtaacggt tgaagatgca 1635781 ttaaaacatc caaactggtc aatgggtgca aaaattacaa ttgattcggc tacaatgatg 1635841 aataagggat tagaggtgat cgaggcacac tggcttttcg atatacctta tgaacaaatt 1635901 gatgtggttt tacataagga gagcatcatc cattcaatgg ttgagttcca tgataaaagt 1635961 gtgatcgcac agctcggaac tccggatatg agagtcccca ttcaatatgc gctcacttat 1636021 cctgaccgat tgccattacc agatgcgaaa aggcttgaat tatgggaaat cggcagcctt 1636081 cattttgaga aagctgattt tgacaggttc cgatgcttac aatttgcttt tgaatcaggt 1636141 aaaataggag gaacaatgcc gacagtgcta aatgcggcaa acgaagtagc tgtcgctgcc 1636201 tttttagctg gcaagatacc gtttttggct attgaagact gtatcgaaaa ggcactaacc 1636261 cgccatcaat tactgaaaaa accgagcctg gcggacattc aagaagtgga caaagatacc 1636321 cggggatacg tcaattcaat actcacataa ggtggtatgt tcgtgaatac agttatagcg 1636381 tttatcatta ttttcggaac gctcgttttc ttccatgaac tgggccattt attgctagcc 1636441 caaagagcgg gaattctctg ccgtgaattt gcgatcggct tcggtccaaa gattttttct 1636501 ttcaaaaaaa atgaaacagt ttatacgatc aggctgcttc cggtcggcgg atttgttcgt 1636561 atggccggcg aagatccgga aatgattgag gtgaaacccg gatacacggt cgggcttctg 1636621 tttaataagg aagatcaagt tgagaaagtc atcatcaatc aaaaggaaaa atatccggat 1636681 gctttagtca ttgaagtgga aacagcggat ctagagcatg acatgaagat caccggttat 1636741 gaacagggga aagaggacga actttccagc tttactgtca gcgaaacatc cttttttatt 1636801 gtagacggag aagaagtgca gattgcgccg tataatcgcc aatttggttc caaacctgta 1636861 tggcagcgga ttaaagcaat tgctgcaggg ccgattatga actttatttt agcttacgtc 1636921 attttagtga tgcttgggct gattcaaggc gtaccgtcaa atgaacctat gctcgggcag 1636981 ctgacagaca atggacgggc ggctgaagca gggctaaaag aaggggatta tatccaaagc 1637041 attaacggag agaaaatgag gtcttggact gacattgtct ccgctgtaaa agaaaacccg 1637101 gagaaagaaa tggacgttgc agtaaaaaga gataacaaaa cgcttcatat ttcggtgact 1637161 ccggaagctg ttaaagatga gaacaaaaaa acaatcggac gtttcggttc ctatgcgccg 1637221 actgaaaaag gcgtactctc agcggttgct tacggcgcga catcaacagt tgatgtcacc 1637281 aaagccattt taaccaatct gagcaaatta gtaacaggcc aatttaaact cgatatgctg 1637341 tcaggtcctg tcggcatata tgacatgaca gaccaagtgg cgaaaacagg gatcgtgaac 1637401 ttatttcagt ttgcggcgtt tttaagcatt aaccttggga ttgtcaacct gcttccgatt 1637461 ccggcacttg acggaggaag actgttgttt ctatttattg aagcgattcg gggcaaaccg 1637521 attaacaggg aaaaagaagc atttgttgtg tttatcggag tagctttctt aatgcttctt 1637581 atgctggttg tcacatggaa cgatatccag cggctgtttt tgtaaacgaa aagtaaatca 1637641 atcagaggtg cgaagaaatg agacaaagct tgacgcttat tcctacgctc cgtgaagttc 1637701 cagctgatgc cgaagcaaaa agtcatcagc ttcttctgag agcaggattt atcagacaga 1637761 atacgagcgg ggtatacagc tatatgcctc ttgcgtataa ggtgattcaa aacattcagc 1637821 agattgttcg agaggaaatg gagaaaattg atgccgtaga aatgctcatg cccgcattgc 1637881 agcaggcaga gacatggcag gaatcaggca gatggtatac gtatggtccc gaactgatga 1637941 gactaaaaga ccgtcatggc cgtgaatttg ctttaggggc aacgcatgaa gaggttatca 1638001 cttcgcttgt tcgcgatgag gttaaatctt ataagcgtct ccctctgact ctttatcaaa 1638061 ttcagtctaa gttcagagat gaaaaacgtc ctcgcttcgg tttgttaaga ggccgcgaat 1638121 ttattatgaa ggatgcgtac tctttccatg catctgcaga gagcctggat gaaacgtatc 1638181 aaaaaatgta cgaggcctat tctaatattt ttgcccgctg cggcattaat gtaagacctg 1638241 ttatcgctga ttcaggcgca atgggaggaa aggatacgca cgaatttatg gcactttctg 1638301 cgatcggaga ggatacgatt gcgtattctg atgaatcaca gtacgcggct aatatcgaga 1638361 tggctgaagt tcttcaccag gaagttcctt cagatgaaga gcctaaagct ctagagaagg 1638421 ttcatacgcc taacgtgaaa acaatcgaag aactgactgc gttcttacag gtttcggctg 1638481 aagcgtgcat taagtcagta ttgtttaaag ctgatgaccg ttttgtctta gtgcttgtaa 1638541 gaggggatca tgaagttaac gatattaaag tgaaaaactt gcttcatgca gaagttgtag 1638601 agcttgctac acatgaagag gtcattcagc agctcggaac agagccaggc tttgtaggcc 1638661 ctgtcggtat tcatcaggat gtggaagtat atgccgatca agctgtgaaa gcaatggtta 1638721 atgctgttgc cggggcaaat gaaggagatc atcattataa aaatgtcaat gtgaatcgtg 1638781 acgcgcaaat taaagaattt gctgatcttc gttttattaa agaaggtgat ccttcaccag 1638841 acggcaaggg aacgatccgt tttgctgagg gaatcgaagt cggacaagtc tttaagctcg 1638901 gaacacgcta ttcagaagcg atgaatgcga catatttaga tgaaaacgga cgcgcgcagc 1638961 caatgctgat gggctgttac ggaatcggtg tgtcaagaac gctttctgct attgctgaac 1639021 agcatcacga cgaaaaaggc ttaatatggc caaaaagcgt tgcgccgtac gatcttcata 1639081 ttcttgcttt gaacatgaaa aacgatgggc aaagagagct tgctgaaaag ctgtatgccg 1639141 atttaaaagc ggaaggctat gaagtgctct atgatgaccg tgctgagcgt gccggcgtaa 1639201 aattcgctga ttcagattta atcggccttc caatccgcat cactgtcgga aaacgagctg 1639261 acgaaggaat cgtcgaagtg aaaattcgtc aaactggtga gtcaactgag atttcagtag 1639321 acgaattatc tgcgtttatc agcaagcagt aatcaccata acgatttatc aaaaaacatg 1639381 ttaaaataga aataatagaa ggtacctcat tgcctgaggt accttcactt atgatgtttt 1639441 tagggaggga tactgtctta atggaacagt tatcagtaaa cagaaggcag tttcaaattc 1639501 ttctgcagca gattaatatg acagatgata ccttcatgac atactttgaa catggcgaga 1639561 ttaaaaagct gacaattcac aaagcttcta agtcttggca ttttcatttt caatttaaat 1639621 ctttgctgcc ttttcaaata tatgacacat taacaacgag gctgacgcaa tcgtttgccc 1639681 acatagcaaa agtgacatct tcaattgaag ttcaggatgc cgaggtcagt gaaagtatcg 1639741 ttcaagacta ctggtcacgc tgcattgaag aactgcaggg catttcgccg ccgattatca 1639801 gtcttttaaa ccagcaaaaa ccgaagctga agggcaataa actgattgtc aaaaccaaaa 1639861 cagatacaga agcggctgcg ctaaagaaca aatacagttc catgattcaa gcagaatacc 1639921 gtcaatttgg ctttccggat cttcagcttg atgctgaaat atttgtatcc gagcaagaag 1639981 ttcaaaagtt tcgggagcaa aagcttgcgg aagaccaaga gcgggctatg caggccttga 1640041 ttgaaatgga gaagaaagat aaagaaagtg atgaagacca agcaccatct ggtcctcttg 1640101 ttatcggtta tcaaattaaa gataacgagg aaatccgaac acttgacagc atcatggacg 1640161 aagaacggag aattacggtc caaggttatg tgtttgatgt ggagacgcgc gagctgaaga 1640221 gcgggcgcac gctgtgtatc ttcaaaatta cagactatac aaatagtatt ttgatcaaaa 1640281 tgtttgcacg tgaaaaagaa gatgcggcgc tgatgaagtc tctgaaaaaa ggaatgtggg 1640341 taaaagcacg cggaagcatt caaaatgata catttgtcag agaccttgtc atgatcgcaa 1640401 atgacgtaaa cgaaataaaa gcaaaaaccc gtgaagattc agcacctgaa ggagaaaaaa 1640461 gagtggaatt gcatcttcat tccccaatga gccaaatgga tgctgttacg ggtatcggaa 1640521 agcttgtcga acaggcgaaa aaatgggggc atgaggccat cgctttgacc gaccatgctg 1640581 tcgttcaatc cttccctgat gcgtattctg cggccaaaaa gcatggaatt aaaatgattt 1640641 acgggatgga agcgaatctc gtggatgatg gcgtgccaat tgcttataat gccgcacatc 1640701 gtctgctcga agaagaaaca tatgttgttt ttgacgttga gacgacagga ttgtctgctg 1640761 tatacgatac cattattgag ctggctgcag taaaagtaaa aggcggagaa attattgata 1640821 aatttgaggc gtttgcgaac ccgcatcgtc cgctttccgc cacaatcata gagctgacag 1640881 ggatcacaga tgatatgcta caagacgctc cggatgtcgt agatgtaata agagatttca 1640941 gagaatggat tggcgatgat attcttgtcg ctcataatgc aagctttgat atgggattct 1641001 taaatgtagc ctataaaaaa cttcttgaag tcgaaaaagc taaaaaccca gtcattgata 1641061 cgcttgaact tggacgtttt ctctatccgg aatttaagaa ccaccggttg aacacacttt 1641121 gtaaaaagtt tgatatcgag ctcacacagc atcaccgtgc gatctatgat actgaggcaa 1641181 ccgcttattt gcttctgaaa atgctgaaag acgcagctga aaaaggtatt cagtaccatg 1641241 atgagttgaa tgaaaatatg ggtcagtcca atgcttatca aagatcaaga ccgtatcatg 1641301 caacattact tgccgtgaac agcacgggac ttaaaaattt atttaagctt gtgtcacttt 1641361 ctcatattca ttatttttac agagtgccgc gtattccgag atctcagctt gagaaataca 1641421 gggaagggct tctgatcggt tctgcttgtg acaggggaga ggtttttgag ggaatgatgc 1641481 aaaaatcgcc tgaagaggtg gaagatatcg cgtcattcta tgattacctt gaggttcagc 1641541 cgcctgaagt gtatcgtcac ttgctggagc ttgaactggt ccgtgatgaa aaagcgctga 1641601 aagaaattat tgcgaatatc acgaagctgg gggaaaagct taataaaccg gttgttgcta 1641661 cgggaaatgt tcattacttg aatgatgagg ataaaatcta cagaaagatt ttaatatcct 1641721 cacaaggcgg ggcaaatccg ctgaataggc atgaactgcc gaaagtgcat ttcagaacga 1641781 cagacgaaat gcttgaagct ttttctttct taggtgaaga aaaagcgaag gagatcgtag 1641841 tcaccaatac ccaaaaggtt gcttctttag ttgatgacat caagccgatt aaagatgatt 1641901 tatatacgcc gaaaatcgaa ggcgctgatg aagagatcag agaaatgagc tatcagcgtg 1641961 caagaagcat ttacggggaa gagctgcctg aaattgtcga agcgcggatt gaaaaagagt 1642021 taaagagtat tattggccac ggatttgctg ttatttactt gatctctcac aaacttgtaa 1642081 aacgttcact agatgacggg tatctcgttg gttcccgtgg ttccgtagga tcttcattag 1642141 ttgcgacact tactgagatt actgaggtaa acccgctgcc gccgcactat gtttgtcctg 1642201 agtgccagca ttctgagttc tttaatgacg gttctgtcgg ttctggtttt gacctgcctg 1642261 acaagacatg ccctcattgc ggaacgcctt tgaaaaaaga cggccatgat attccatttg 1642321 aaacgttctt aggatttaaa ggggacaaag tacctgatat cgatttgaac ttctcagggg 1642381 aatatcagcc gcaagcacac aattacacaa aagtattgtt cggagaagac aatgtatatc 1642441 gtgcgggaac aataggcacg gtggcagaaa aaacagccta cggttatgta aaaggctatg 1642501 ccggagacaa caatcttcat atgcgcggtg ccgaaataga tcggctcgta cagggatgca 1642561 caggtgtaaa acgtacaact ggacagcacc ctggcggtat tatcgtagtt ccggattata 1642621 tggatattta tgatttttca ccgatccagt tcccggcaga tgccacaggt tcagagtgga 1642681 aaacgactca ttttgatttc cactccatcc atgacaacct gttaaaactt gatattctcg 1642741 gacacgatga cccgactgtt attcggatgc ttcaagactt aagcggaata gatccgaaaa 1642801 caattccgac ggatgatcct gaagtgatga agatcttcca gggaaccgaa tcactcggtg 1642861 tgactgaaga acagattggc tgtaaaacgg gcactcttgg aattcctgaa ttcggaaccc 1642921 gatttgtccg gcagatgctt gaagatacaa agccgaccac tttttctgag ctcgttcaga 1642981 tttcaggctt gtctcacgga actgatgtat ggcttggcaa tgcacaggag ctcatccaca 1643041 ataatatttg tgagctgagt gaggttatcg gctgccgtga tgacattatg gtttatttaa 1643101 tctatcaagg ccttgagccg tcccttgcct ttaaaatcat ggaattcgtg cgtaaaggaa 1643161 aaggattaac gcctgaatgg gaagaagaaa tgaaaaataa caatgtccca gactggtata 1643221 ttgattcctg taaaaagatt aaatacatgt tcccgaaagc ccacgccgcg gcatatgtct 1643281 taatggcagt ccgcattgct tactttaaag tgcatcatgc tcttttgtat tatgcggctt 1643341 attttaccgt tcgtgcagat gactttgata ttgatacaat gatcaagggc tctacagcaa 1643401 tcagagcggt aatggaggat ataaacgcta aaggacttga tgcttcaccg aaggaaaaga 1643461 accttctgac tgttttagaa ttagcgcttg agatgtgtga gagaggctat tcattccaaa 1643521 aagtcgattt atatcgctcc agcgccacag agtttattat tgacggcaac agtcttattc 1643581 cgccgtttaa ctctattcca gggttaggga cgaacgctgc tttgaacatt gtaaaagctc 1643641 gcgaagaagg cgaattcctc tcaaaagaag atttgcaaaa gagagggaaa gtatcaaaaa 1643701 cgattttaga gtacttagat cgccatggct gtctggagtc actgcctgat caaaaccaat 1643761 tgtcactgtt ctaatatgga aagcagaatt tctcagaaat tctgcttcta tgcatacata 1643821 agcgcaaaaa gtgccatcgt aatattagag tttctgtcac ttgcttaggt atgaaggtaa 1643881 gcgtatatcc atttgcaata aaaatatggt tatggtatag ttttattgga aatgctaacg 1643941 attaccgagg caaagagtgg ggaaacccgc tcttttgtat tgaacaggag aattttgtct 1644001 cgacatgttc atcgtttact ttttagcccc tgctcttttg aagcagggtt tttatgcaga 1644061 gtgacgagac gaatatgaga tcgacagcac aaggaggaag aacatgagca aaaaagtgac 1644121 tgacaccgtt caagaaatgg ctcagccaat cgtagacagc cttcagctgg aactcgttga 1644181 cattgaattt gtcaaagagg gccaaagctg gttccttcgc gtgtttattg attccgatga 1644241 cggtgtggat attgaggaat gtgccaaagt aagcgaagct ttaagcgaaa agcttgatga 1644301 ggcagaccca atcagccaaa attactttct tgaagtctca tctccaggag ctgagcgtcc 1644361 gctaaagaaa aaagccgatt tcgaaaaatc actaggaaaa aacgtataca ttaagacgta 1644421 tgagcctatt gacggcgtaa aagtgtttga aggtgaactg gctgaatttg atggacaaac 1644481 agtgacagtt gagatcacga tcaaaacaag aaagaaacgg atcaatattc cgtatgaaaa 1644541 gatagctaat gcaagattag ctgttacatt ctaatgaata caaatgtttt aaggggggag 1644601 accgttaaat gagcagtgaa ttattagatg ctctcacgat tcttgaaaaa gaaaaaggca 1644661 tcagtaaaga aattatcatc gaagcaatcg aagctgcgtt aatttctgct tataagcgga 1644721 attttaatca agcgcaaaat gtacgggtgg atctaaaccg tgaaactggc tccatccgtg 1644781 tatttgcaag aaaagatgtc gttgacgaag tatacgacca gagattagaa atctcaattg 1644841 aagaggcaca gggcatccat ccggaatata tggtcggcga tgtcgtcgaa atcgaagtta 1644901 cacctaagga tttcgggcgc atagctgctc aaacagcgaa gcaggtcgtc acacagcgtg 1644961 tgcgcgaagc tgagcgcggt gtgatttatt ctgaatttat cgaccgtgaa gaagacatca 1645021 tgacagggat cgtccagcgt ctggacaata aatttatcta cgtgtcttta ggcaaaatag 1645081 aagccttgct gccggttaat gagcaaatgc cgaatgaaag ctacaagccc catgaccgca 1645141 ttaaggtata tatcacaaaa gtagaaaaaa caacgaaggg tccgcagatt tatgtgtcaa 1645201 gaacacatcc aggcctgtta aagcgtttgt ttgaaattga agtgcctgaa atttatgatg 1645261 gaactgtcga gctaaaatct gttgccagag aagccggcga ccgttcgaaa atttctgttc 1645321 gcacagatga tcctgacgtt gatcctgtcg gttcatgcgt agggcctaaa ggccagcgtg 1645381 tgcaagcaat cgtcaatgaa ttaaaaggtg aaaaaattga cattgtcaac tggtccagtg 1645441 atcctgtaga atttgtcgcg aatgcgctca gcccttccaa agtgcttgat gtcattgtta 1645501 atgaagaaga aaaagcgaca actgttattg ttcctgatta ccagctgtct ctggcaattg 1645561 gaaaaagagg acaaaacgca cgcttagctg ctaaactgac aggctggaag attgatatta 1645621 agagcgaaac ggacgcaaga gaacttggaa tctatccgag agaacttgaa gaagatgatg 1645681 agccgctctt tacggagcct gaaactgctg aatcggatga ataagaggtg actttaggtg 1645741 aataaacaca aaaagatccc attacgcaaa tgtgtagtga ctggtgaaat gaagcctaaa 1645801 aaggaactga tccgagttgt acggtcgaaa gaaggcgaaa tctcagtaga cccgaccgga 1645861 aaaaagaatg ggcggggtgc ttatttaacg ctggataaag agtgcatctt agcagcaaaa 1645921 aagaaaaaca ctttgcaaaa tcaatttcaa tcacaaatcg atgaccagat tttcgatgaa 1645981 ttgctggaac tggcggaaaa ggtgaaaaaa taaaatgtct ggaatggaat ggtttccctt 1646041 gctgggtctg gccaatcgag ctcgtaaggt cgtgtcaggc gaagacttgg taataaaaga 1646101 aatcaggaat gcgcgtgcaa agcttgtcct gcttacagag gatgcatcat ctaacacagc 1646161 aaaaaaagta actgacaagt gcaattatta taaagtccct tataaaaaag tcgagagtcg 1646221 cgcggttctt ggacgctcta tcggtaaaga agcccgtgtc gttgtcgccg tcactgacca 1646281 aggttttgcg aataagctga tcagcttgct cgattaatat ttttgggggt gaacgaatgg 1646341 ctaaaatgag agtatacgaa tatgcaaaag cgttaaatgt ttcaagtaag gaaattttga 1646401 ccgcactgaa gaacatggat ttagaagtga ataatcacat ggccatgctt gaagaaaagg 1646461 ccattaaaaa gctagatgcc aaatataaaa aaggcggcgc agctgctaaa tctcaaaagc 1646521 cagcagaaac gaacaaaaac aaacagccac aaggggttaa tcagcaatca gctggaaatc 1646581 aaccaaataa aattcgagac ggaaagaaga atgacgtgca gaataatcaa tttaacaaaa 1646641 acaagaagaa taacaacaac aaaaaaaata aacgcaacaa caacaataat aaaaaccaac 1646701 atcagcaaaa gcctgtaaag ccgaaaaaag agcttcctga gaaaattaca ttctctggca 1646761 ctttaacagt tggcgcactt gctgaagagc ttggcaaaga gccttcagaa ctcattaaaa 1646821 agctgatgct tcttggcgta atggcaacca ttaaccaaga gcttgataaa gacacaatcg 1646881 aactcattgc atcagaatat ggtgttgaaa cagaagaggt cattgtgctt gaagaaacag 1646941 agctggaaaa atacgaagag cctgataatg aagaggatct tgaaattcgt cctcctgtcg 1647001 tgacaatcat gggccacgtt gaccatggga aaacaacgct tcttgacagc atccgtaaaa 1647061 caaaggttgt tgaaggggaa gcaggcggaa tcactcagca tatcggcgct tatcaaattg 1647121 aagagaacgg caagaaaatc acgttcttgg atacaccggg ccacgccgca tttacaacaa 1647181 tgcgcgcacg cggtgcagaa gtaactgata ttacgattct tgtcgtagct gccgatgacg 1647241 gtgtcatgcc gcaaacagtt gaagcgatta accatgcaaa agcagcagag gttccaatca 1647301 tcgttgctgt gaataaaata gataaagaat ccgcaaaccc tgaccgtgta atgcaagaac 1647361 tgacggaata cggacttgtc cctgaagctt ggggcggaga aaccattttt gtgccgcttt 1647421 ccgctttaac tggaaaaggc attgatgagc tcgttgaaat gattttgctt gtcagtgagg 1647481 tagaggaact gaaagcgaat ccgaatcgtc aggcaaaagg aacggttatt gaagctgaac 1647541 tcgataaagg cagagggtca gtcgcgacgt tgctcgtaca gactggaaca ctgcatgtcg 1647601 gtgatccgat cgtagtcggc aatacatttg gccgtgtccg tgcaatggtc aacgacattg 1647661 gccgccgtgt gaaaactgcc ggcccgtcaa ctccggttga aattaccggt ttgaatgatg 1647721 tccctcaagc gggagaccaa ttccttgtct ttaaggatga aaaaacagct cgttctgtcg 1647781 gtgaagcccg tgcttcgaaa cagcttgaag agcagcgcag cgataaagcg aagctcagtc 1647841 ttgatgattt atttgagcaa attaagcaag gtgatgtaaa agacatcaac ctcatcgtaa 1647901 aagctgacgt tcaaggatct gctgaagctt taacggctgc acttcaaaaa attgaagtag 1647961 aaggcgttaa agtgaaaatc atccatacag gcgttggtgc gattactgaa tcagacatta 1648021 tcttggcatc tgcttccaat gcaattgtta tcgggtttaa tgtgagaccg gacggaaatg 1648081 ctaagagtac ggctgaagct gaaaatgtag atattcgact tcaccgtatc atttacaaag 1648141 taatcgacga gattgaagct gccatgaaag gtatgcttga tcctgaatat gaagaaaaag 1648201 taattggtca agtagaagta cgccaaacat tcaaagtatc taaaatcggt acaattgccg 1648261 gcggatatgt tactgaagga accattacgc gcgacagcgg cctccgttta attcgtgacg 1648321 gcgtcgtcat ctttgaaggc gaagtagatg ttctgaaacg ctttaaagac gatgtgaaag 1648381 aagtttcaca aggctatgaa tgtggtatta caattaagaa atacaatgac attcgtgaag 1648441 gtgacatcct tgaagcgttt gtcatgcaag aaattgaaag aacgtgatcg gatttgcgga 1648501 gtgtgaatgc atcatttatg atgcaggatc gctaaaagaa aagcgtgccg ttctgaagcg 1648561 gattttaacc agggttcaaa acaagttcaa tgtttcgatt tcggagattg gctatcagga 1648621 cacctggcaa agaaccagct tcggaatcgc cgctgtttct tcctctcgcg ttcaaacaga 1648681 aaaagaactg cagcgcgtcc tagcgtttat cgattctttt cctgaaattg aacggacgat 1648741 cactaggaca gagtggtttt aacttagagg tgattgaatt gagtatgaga gcaaaccgtg 1648801 tcggcgagca aatgaaaaaa gaactcggtg atattatcag ccgcaagctg aaagacccga 1648861 gaattggttt tctgacagta acggatgtac gtgtatcagg tgatttgcaa attgcaaagg 1648921 tgtatatctc ggttctcggt gacgagaaaa aacgggaaga agcgctgaaa gggctggcaa 1648981 aagcgaaagg atttatccga tccgaaatcg gcagccgcat cagacttcga aaaacgcctg 1649041 aaattgaatt tgagttcgat gaatcaatcg attacgggaa tcggatcgaa acactgattc 1649101 acgaattaca ttcagagaaa ccatctgaat aaaaaaagag aggataggcg tatatcgtct 1649161 gtcctctttc ttcgtttata agaaaaaaac tcaaaagaag gagtgaaagg caaatggtta 1649221 acggagttct ccttttacat aaacctgttg gcatgacatc gcacgactgt gtcatgaaga 1649281 tccgaaagct gttaaaaaca aaaaaagtag gacatacagg aacgctcgat ccggaagtat 1649341 caggcgtgct tccgatttgt gtaggaagag cgacaaaaat agtcgaatac ttaactgaaa 1649401 aatctaaaac gtatgatgca gaaataacat tgggcttttc aaccacaaca gaggatcaaa 1649461 ccggagaaac ggtggaaaca aagcctgtca atcacgacat tgataaagcg gatgtagaaa 1649521 aggttttaaa cagtttaaag gggaaacaag aacaaattcc gcccatgtat tccgctgtaa 1649581 aagtaaacgg caaaaaatta tacgaatacg caagagcagg gattgaagta gaacgtccga 1649641 aacgtatgat aaccattgaa gacattgccc tgacaacaga gattaaacat catggagaaa 1649701 ccgcaagctt ccggtttaca gtgacttgct ccaaagggac ctatgtaagg acgctggcgg 1649761 tcatgatcgg agaaaagctc ggatatccgg cccatatgtc tcatttaatc cgtacggcat 1649821 ccggagattt ttctctcgac gaatgcttta cttttgatga actcgaagca caggcccaat 1649881 ccggaaccgt ggaagagcat acagttccta ttgaacgtgc gctcaatcat ttgccgaaat 1649941 ggatcataag tgatacatta gctaagaaag tagaaaatgg ggctttgctt gagacgcccg 1650001 agcagttttc tgaaatgaca agtggagacc gtattgccgt ctttactgaa tccggaacct 1650061 gcttggcgat ctatttccct catcctgcaa aaaaagggct gttaaagccg gcaaaagtat 1650121 tgatgcaaaa aagcgaacaa tagaaaaaag gtgaccgttc tgtgaagacg atacatatta 1650181 cacatcctca tcatttaata aaagaggagc aggcaaaatc agtgatggcg ttaggttatt 1650241 ttgacggcgt tcatctcggg catcaaaagg taatcggcac agcgaagcaa atagccgaag 1650301 aaaaaggtct gacattagct gtgatgacct ttcatcccca tccttctcac gtgttgggca 1650361 gagataagga accaaaggat ctgattacgc ctcttgaaga caaaataaac caaattgaac 1650421 aattaggcac agaagttctg tatgtcgtta aatttaatga agtgtttgct tctctttctc 1650481 ctaagcagtt tatagaccag tatattatcg gccttaatgt gcagcacgca gtggcaggct 1650541 ttgactttac gtacggcaaa tacggcaagg gaacaatgaa gaccatgccg gatgatttag 1650601 acggaaaagc tgggtgcaca atggtagaaa aattaacgga gcaggataaa aaaatcagtt 1650661 cttcgtatat ccgtaccgcg cttcaaaacg gagatgttga attggcgaat gtcttgcttg 1650721 gacaacctta ttttattaaa ggaattgtca ttcatggtga taaaagaggg cggaccatcg 1650781 ggtttccgac agcgaatgtc ggtttaaata acagctatat cgttccgccc acaggtgtat 1650841 atgccgtaaa agcggaagtg aacggcgaag tttacaatgg cgtttgcaat attggctata 1650901 agccaacgtt ttatgaaaag cgccctgaac agccttccat cgaggtcaat ctgtttgatt 1650961 tcaatcaaga ggtatatgga gccgctataa aaatcgaatg gtacaaacgg attcggagcg 1651021 agcggaaatt caatggcatc aaagaattaa ctgagcaaat tgagaaagat aagcaggaag 1651081 ccatccgtta tttcagcaat ttgcggaaat aacttgcaac gcacgcaaat tttattctaa 1651141 aatatttgca tataggcacg atttttagta tgatagtttt cgtagtctta aaaccattgc 1651201 ttggcaatcc gaagtcaccg acggttgcta ggtaactggg gctaaatatg atttggaggt 1651261 gaaacaggat ggcaattact caagagcgta aaaaccaact catcaatgag ttcaaaacac 1651321 acgaatctga tactggatct ccagaagttc agatcgctat cctaactgac tcaattaaca 1651381 acttgaacga gcatttacgt actcacaaga aagaccacca ctcacgtcgc ggtcttctta 1651441 aaatggtagg taagcgtcgt aatcttctta cgtatctgcg taataaagac gtaactcgtt 1651501 accgtgagtt aattaacaaa ctaggcttac gtcgataatc gtaaaaagcg ggaggattcc 1651561 cgctttttta tcgtattaaa gcgaaatttc ttataacaaa tcattgaaat ccttttacat 1651621 actactttga cattgatatg ttcaattcat ttcgttcata ataggagtaa ttgattattt 1651681 cacacaacga agagaggagt tcgtaattgt atgggacaag aaaaacatgt ctttaccata 1651741 gattgggccg gaagaacgct taccgttgaa accggccagc ttgccaaaca ggcaaatggt 1651801 gctgtgatga tccgctacgg tgatacagca gtacttagta cagcaaccgc ttcaaaagaa 1651861 cctaaaccgc ttgatttctt ccctcttact gtaaactatg aagaaagatt atatgcggta 1651921 gggaaaattc cgggcggatt tattaaaaga gaaggacgtc caagtgaaaa agcggttctt 1651981 gccagccgtt taattgaccg tccgatccgt cctttgtttg ccgatggatt ccgtaatgaa 1652041 gttcaagtca tcagcattgt catgagtgtt gaccaaaact gctcttcaga aatggctgcc 1652101 atgttcggtt catctcttgc actttctgta tcggatattc cgtttgaagg accgattgca 1652161 ggggttactg tcggacgcat tgatgatcaa tttatcatta acccgacagt cgatcagctt 1652221 gaaaaaagcg atatcaatct tgtcgttgcc ggcacgaaag atgcgattaa catggtagaa 1652281 gcgggagcgg acgaagttcc tgaggaaatc atgcttgagg ccattatgtt cggccatgaa 1652341 gagattaaac gcctgattgc attccaagaa gaaattgttg cagcagtcgg caaagagaaa 1652401 tctgaaatta agctctttga aattgatgaa gagcttaatg aaaaagtaaa agctttggca 1652461 gaagaggatc tgctgaaagc catccaagtt catgaaaagc atgcccgtga agatgccatt 1652521 aacgaagtga agaacgcagt tgtggcaaaa ttcgaggatg aagaacatga tgaagacaca 1652581 atcaagcaag tgaagcagat tttatccaag cttgtgaaaa atgaagttcg ccgcctgatt 1652641 actgaagaga aagtaagacc ggacggccgc ggtgtcgatc aaatccgtcc gctctcttca 1652701 gaggttggcc tcttgccaag aacgcacggt tcaggtctat ttacaagggg acaaactcag 1652761 gccctcagcg tatgtacgct aggtgctctg ggagatgtgc aaatccttga cggcttaggt 1652821 gtcgaagagt cgaaacggtt tatgcatcat tacaacttcc cgcaattcag cgttggggaa 1652881 acaggaccga tgcgcggacc gggacgtcgt gaaatcggac acggagcact gggtgagcgt 1652941 gcgcttgagc cagttattcc gtctgaaaaa gacttccctt atactgtccg tcttgtttca 1653001 gaagtgcttg aatcaaacgg ttctacatct caagcaagca tttgcgcaag cacacttgca 1653061 atgatggatg ccggtgtacc gattaaagcg ccagttgctg gtattgcgat gggtcttgtc 1653121 aaatcaggcg aacattacac tgtcttgact gacatccaag gcatggaaga cgcgctcgga 1653181 gatatggact ttaaagtagc gggaactgaa aaaggcgtaa cggccctgca aatggacatt 1653241 aaaattgaag gcctttccag agagattctt gaagaagcgc ttcagcaggc gaaaaagggc 1653301 agaatggaaa tcctcaacag catgcttgca acattaagcg aatcaagaaa agagctttct 1653361 cgatatgcgc ctaagatctt aacaatgacc attaatcctg ataaaatccg cgatgtcatc 1653421 ggaccaagcg ggaaacaaat caataagatc atcgaagaaa ccggtgttaa aattgatatt 1653481 gagcaggacg gcacaatctt tatttcctct acagatgaaa gcggcaacca aaaagcgaaa 1653541 aaaatcatcg aagaccttgt gagagaggtt gaagtcggcc aactttacct aggtaaagtg 1653601 aaacggattg aaaaattcgg ggctttcgtt gaaattttca gcggaaaaga cggtttggtg 1653661 cacatttcag agcttgcgct tgaacgcgta gggaaagttg aagatgttgt gaaaatcgga 1653721 gacgagattc ttgtcaaagt cactgaaatt gataaacaag gacgagtgaa tttatcccgc 1653781 aaagcggtgc tccgtgaaga gaaagaaaaa gaagaacaac aatcttaaat gaaaacataa 1653841 aaggagcctg ggagacccgg cttctttatt ttgaagcttt tcaaaagcag gcgggttcta 1653901 ccttgtcctt ctccttcata atgtgaggtg agggggggac agaacatgta caaaaaattt 1653961 gtaccgtttg ccgttttttt atttcttttt tttgtctcat ttgagatgat ggaaaatccg 1654021 catgcacttg attatatagg ggcaatgaaa aaagatacgg tgactgtcac ggcgtcaaaa 1654081 gacccgttat atgaagaatt gcttcaaaaa gcgccggagt acgaagttaa gccccagaat 1654141 gcaagaattg ataaagtgtg gaaaagcatt ccaggctaca atggattaaa ggtcaatatt 1654201 gaacaatcat ataaaaaaat gaaacagcat ggtaagtttc gggaaaaaga tttggtgtac 1654261 agtcaagtaa aaccaagtgt tcatcttgag tcacttcagc ctgagcctat ttataaagga 1654321 aatcctgaca aaccgatggt ggctttttta atcaatgtgg catggggaaa tgagtatttg 1654381 gaaaaaatgc ttcctattct gcaaaagcac caggttaaag ctacgttctt tttagaaggc 1654441 aattgggtga gaaacaatgt acagctcgct aagaagattg caaaagacgg acatgaaatc 1654501 ggaaatcatt catacaatca tccggatatg agcaaactga ctacaggaag aatttccgag 1654561 cagctcgaca agactaatga acaaatagaa caaacgatcg gcgttaagcc aaagtggttc 1654621 gctccgccaa gcggaagttt cagaaaagcg gttatcgaca ttgcagcaga gaaacagatg 1654681 ggaacagtca tgtggacagt tgatacaatc gattggcaaa agccggctcc gtctgtactt 1654741 cagacgagag tgttaagcaa gatacataat ggtgccatga ttttaatgca tccgactgac 1654801 cctacggcgg aaagtcttga agcgctgatt acacagataa aagacaaagg atatgcgctt 1654861 ggaacagtca ctgaactaat ggatgaaaca agactattga agtaacagat gaaggcagct 1654921 tgtctttgaa taggaggaac aaatttgatt aaacgatata cgtgtcaaaa tggtgtaaga 1654981 attgtgctgg aaaataaccc gacagtccgt tctgttgcga tcggcgtatg gatcggcaca 1655041 ggttcgagac atgaaacgcc ggagataaac ggaatttctc actttttaga gcacatgttc 1655101 tttaaaggga cgagcacaaa atctgcacgc gagatagcag aatcttttga tcgtattggc 1655161 ggccaggtca atgcgtttac ttcaaaggaa tatacctgct actatgcaaa ggtgcttgac 1655221 gagcatgcga attacgcgct ggacgtatta gcagatatgt tctttcattc aacgtttgat 1655281 gaaaacgagc tgaaaaaaga gaaaaatgta gtatatgaag aaattaaaat gtatgaagat 1655341 gcgccggacg acattgtaca tgatttattg agcaaagcca cttacggcaa tcattcttta 1655401 ggctacccaa ttttaggaac ggaagaaacg cttgcttcct ttaacggtga ctctctcaga 1655461 caatacatgc atgattatta tacgccggac cgagtggtga tttcggtagc gggcaatata 1655521 tctgacagtt ttatcaaaga tgtagaaaaa tggttcgggt catacgaggc gaaaggcaaa 1655581 gcgacaggcc ttgagaagcc tgagttccac acggaaaaac tgacgagaaa aaaagaaaca 1655641 gagcaggctc atttgtgcct tggatttaaa ggcttagagg ttggccatga acgtatttat 1655701 gatttaatcg tcctcaacaa tgtgctcgga ggcagcatga gcagccggct gttccaagat 1655761 gtgcgtgaag ataaaggact tgcttattct gtttacagct atcacagctc atatgaggac 1655821 agcggaatgc taacgattta cggcggaacg ggtgcaaatc agcttcagca gctgtcggaa 1655881 acaattcaag aaaccctggc cacattaaaa cgtgacggca ttacctcgaa agaactggaa 1655941 aacagcaaag agcaaatgaa gggaagctta atgctgagct tagaaagcac aaacagcaaa 1656001 atgagccgaa acggaaaaaa tgaactgctg ctcggcaaac ataaaacatt agatgaaatt 1656061 atcaatgaat taaacgccgt gaacttagag cgtgttaatg gccttgccag acaattgttt 1656121 accgaagact atgcattagc acttatcagc ccttccggca atatgccgtc ttaaaaagga 1656181 aagcctgccc cataatggag caggcatttt ttaatccctt tcatcataca tagtacaagg 1656241 gggtgacaga catgcggctc agtgaattat cgggaaagga aattgtagac atcaaaagag 1656301 ctgaacggct cggagtgctc ggccagaccg atttggaaat caatgaacag gatggacaga 1656361 ttacagcact cctcattccc acagttaagt ggtttggttt gagaaagcaa ggtcatgaca 1656421 ttcgtgtccc atggcaccat attcaaaaga tcggttcaga tatgattata ttagatgtac 1656481 ctgaggaaat gcctcctcga caagagtaaa tagcccaatt gactgtgaag cgggctctaa 1656541 agaaaacatc tgaaacatcg gctgccggag ccgatgtttt tttatatgga aaaagcgcat 1656601 cttttatatt caccggtatt tccttttgat cataagatga aggggagctt aacaactaga 1656661 gatccagtat atacaaagaa ggtgaacgtt tagaatgtta accggattga aaattgcagt 1656721 tatcggcggt gacgcaagac agctcgaaat tataagaaag ctcactgaac agcaggctga 1656781 catctatctt gtcggttttg accaattgga tcacggtttt accggggcag taaaatgcaa 1656841 tattgatgaa attccttttc agcaaataga cagcatcatt cttccagtat ccgcgacaac 1656901 aggagaaggt gtcgtatcga ctgtattttc gaatgaagaa gttgtgttaa aacaggacca 1656961 tcttgacaga acgcctgcac attgtgtcat tttctcagga atttctaacg cctatttaga 1657021 aaacattgca gctcaggcaa aaagaaaact tgttaagctg tttgagcggg atgacattgc 1657081 gatatacaac tctattccga cagtagaagg aacgatcatg ctggctattc agcacacgga 1657141 ttatacgata cacggatcac aggtggccgt tctcggtctg gggcgcaccg ggatgacgat 1657201 tgcccgtaca tttgccgcgc tcggggcgaa tgtaaaagtg ggggcaagaa gttcagcgca 1657261 tctggcacgt atcactgaaa tggggctcgt tccttttcat accgatgagc tgaaagagca 1657321 tgtaaaagat atagatattt gcattaatac cataccgagt atgattttaa atcaaacggt 1657381 actttctagc atgacaccaa aaaccttaat attggatctg gcctcacgtc ccgggggaac 1657441 ggattttaaa tatgccgaga aacaagggat taaagcactt cttgctcccg ggcttccagg 1657501 gattgtcgct cctaaaacag ctgggcaaat ccttgcaaac gtcttgagca agcttttggc 1657561 tgaaatacaa gctgaggagg ggaaataagg atgtcgtcat taaaaggaaa aagaatcggg 1657621 tttgggctga ccgggtcgca ttgcacatat gaagcggttt tcccgcaaat tgaggagttg 1657681 gtcaacgaag gagctgaagt ccgtccggtt gtcacattta atgtaaaatc tacaaatacc 1657741 cgatttggag agggcgcaga atgggttaaa aaaattgaag acctgactgg atatgaggcc 1657801 attgattcga ttgtaaaggc agaacctctt gggccgaagc tgccccttga ctgcatggtc 1657861 attgcgcctt taacaggcaa ttcaatgagc aagctggcaa atgccatgac ggacagcccg 1657921 gtgctgatgg cggcaaaagc gacaatccgg aacaatcggc ctgtcgttct gggtatctcg 1657981 acaaatgatg ctcttggttt aaacggaaca aatttaatga ggctcatgtc aacaaaaaat 1658041 atctttttta ttccattcgg gcaagatgat ccatttaaaa aaccgaattc aatggtagcc 1658101 aaaatggatc tgcttccgca aacgattgaa aaggcactca tgcaccagca gcttcagccg 1658161 attctagttg agaattatca gggaaatgac taaatttaca gaaaatcttt cccaaactaa 1658221 aaaattcggt catcacccgc atattctatg gtaaaataaa acgtaaaatc atagtcaaat 1658281 caattcaatg aagctgattg gcggaaggag ttttacagat gggaagaggt ttacacgtag 1658341 ctgttgtcgg agcgacaggg gctgtgggac aacaaatgct taaaacactt gaagacagaa 1658401 actttgaaat ggacacactt acattgctat cttcaaaacg ctctgcgggg acaaaagtca 1658461 cgtttaaagg ccaagagctg actgttcagg aagcttctcc tgagagcttt gaaggggtaa 1658521 atattgcttt gttcagcgcc ggcggaagcg tatcacaagc attggcacca gaagctgtaa 1658581 aacgcggcgc tattgttata gataatacga gtgcgttccg catggatgaa aatacaccgc 1658641 ttgttgtgcc agaagtgaat gaggcagact tgcatgaaca caacggcatt attgccaatc 1658701 caaactgctc tacaatccaa atggttgcgg cacttgaacc gatccgcaaa gcatatggct 1658761 taaacaaggt catcgtatca acttaccagg cagtatcagg agcgggtaat gaagctgtaa 1658821 aagagcttta cagccaaaca caggcgattt taaataaaga agaaatagag cctgagatca 1658881 tgcctgtaaa aggtgacaaa aaacactatc aaatcgcctt caacgcgatt ccgcaaatcg 1658941 ataaattcca agataacggc tatacgtttg aggaaatgaa aatgataaat gaaacgaaaa 1659001 aaatcatgca catgcctgac cttcaagtag cggctacatg tgtgagactg ccaatccaaa 1659061 ctgggcactc agagtccgtc tacatcgaaa tagaccgtga tgacgctaca gttgaagata 1659121 ttaaaaatct attgaaagaa gctccgggcg tgacacttca ggatgatcca agccagcagc 1659181 tttatccgat gcctgctgat gctgtcggca aaaacgatgt gtttgtaggc cgcatccgca 1659241 aagacttgga cagagcaaac ggttttcatt tatgggttgt ttctgataac ctattaaaag 1659301 gcgcggcatg gaactctgtt caaattgcag aaagcctgaa aaaactaaac ctcgtataaa 1659361 agagagaatt ttctaaagac gaatagaaga gagtaaggcg ctatcagcct gctctcttct 1659421 gttacgtccg aataatttgg agtgaaaaca gtgaagataa ttgttcaaaa gttcggcgga 1659481 acatcagtaa aagatgataa aggccgcaaa ctggctttag ggcatattaa agaagcaatc 1659541 agtgaaggat ataaggttgt cgttgtcgtt tcagcgatgg gccgaaaagg ggacccgtat 1659601 gcaacagatt ctttgctcgg gctgctttac ggcgatcagt cagcgatttc tcctagggag 1659661 caggatttgc ttttatcttg cggagagact atttcctctg tcgtctttac aagcatgctg 1659721 cttgataacg gtgtgaaagc agctgcgctg acaggggctc aggctggctt tttaacgaat 1659781 gatcagcata ctaatgcgaa aatcattgaa atgaaaccgg agcgtttatt cagtgtgctc 1659841 gccaatcatg atgcggtagt cgtcgcaggc ttccagggcg caactgaaaa gggtgataca 1659901 acaacaatcg gcagaggggg cagcgatacg tctgcagccg cactcggagc agctgttgat 1659961 gcggaataca tcgatatttt caccgatgta gaaggcgtga tgactgctga cccaagagtg 1660021 gtagaaaatg caaaaccgct tcctgttgtg acgtatacgg aaatctgcaa cctggcgtat 1660081 cagggggcca aggtcatttc tccgcgtgct gtggaaatcg caatgcaggc caaggttccg 1660141 atccgcgtcc gttcgactta ttcgaatgat aaaggcacat tggtgacatc acatcactct 1660201 tccaaggtcg gcagtgatgt ttttgaaagg ctgattacgg gaatcgccca tgtcaaagat 1660261 gtcacgcagt tcaaagtgcc tgcgaaaatc ggccagtata acgttcagac tgaagtgttc 1660321 aaggctatgg caaacgctgg aatcagtgtc gatttcttta acattacacc tagtgaaatc 1660381 gtctatacgg tagccggaaa taaaacagaa acagctcagc gtattttaat ggatatgggc 1660441 tatgatccaa tggtgacgag aaactgcgcg aaggtatcgg cggtcggcgc gggcattatg 1660501 ggtgttcccg gtgttacgtc caaaattgta tcggctcttt cagaaaaaga aattccgatc 1660561 cttcagtcgg ctgacagcca tacgacgata tgggtgctcg tccatgaagc ggatatggtt 1660621 cctgctgtaa acgctttgca tgaagtgttt gaactttcga agtaaatgtg attgaatcat 1660681 gatgaggtga ataaaatgaa tttcggaaat gtgtctacag cgatgattac accctttgac 1660741 aataaaggga acgtagactt tcaaaaactg tctacactga ttgattactt gttgaaaaac 1660801 ggaacggatt ctttagtagt agcgggaaca actggagaat ctccgaccct ttcaactgaa 1660861 gaaaaaattg cgctttttga atatacggta aaagaagtaa acggacgggt gcccgttatc 1660921 gctggtactg ggagcaacaa cacgaaagat tccattaagc tgacaaaaaa agctgaggaa 1660981 gcgggcgtgg acgctgttat gcttgttacc ccgtattaca ataaaccttc tcaagaagga 1661041 atgtaccagc attttaaagc aattgcggca gagacatctc ttccggttat gctctataat 1661101 gttcctggcc gtacggttgc ttctcttgct cctgaaacga cgatccgttt ggcggcagac 1661161 attccgaatg tggttgcgat taaagaagcg agcggagacc tcgaagcgat tacaaaaatt 1661221 attgctgaaa cacctgaaga cttctatgtc tattcagggg atgatgctct aacgcttcca 1661281 attctttcag ttggaggtag aggagttgtg tcagtggcga gccatattgc aggcactgat 1661341 atgcagcaaa tgatcaaaaa ttatacgaat gggcaaacag ctaatgcggc actgattcat 1661401 cagaaactgc tgccgattat gaaggaactg tttaaagcgc ctaatcctgc tccagtcaaa 1661461 acagcgcttc agctgagagg tcttgatgtc ggttctgtgc gtctgcctct agtcccatta 1661521 actgaggatg aacgtctgag cttaagcagc acgatcagcg aactgtaaga aaatttcata 1661581 cagtgaaaca aacgcggtca ttctcacatt cagctgagtt tgaccgtttc ttttacatat 1661641 tggttttccc taaaccttct gctttatctt gttttctaaa tttactttca gttataatag 1661701 gaacaagtga tgatggacgg gtatgagact aggaggatat agattttgaa aaagaaaaat 1661761 acagaaaacg ttagaattat cgcccttggc ggtgtcggag agattgggaa gaacctttat 1661821 gtcattgaaa ttgactcaga catatttgtc gttgatgccg gccttatgca tccagaaaac 1661881 gaaatgctcg gtattgatgt agtgattcct gacatatcat atttgattga acgggctgac 1661941 cgcgtcaagg caatcttttt aacgcacggg cacgatgaaa atatcggcgg cgttttttac 1662001 ttattaaaca agctgtccgt tccagtgtac ggaacaaaac tgacgcttgc actgttaaga 1662061 gagaaattaa aacaatacgg acataaccga aaaactgatt taagagaaat tcactccaaa 1662121 tctgtcatta catttgaatc aacaaaggta tcgttcttta gaacgattca cagcattcct 1662181 gattctgtag gtgtgagctt taaaacatca cttggatcta ttgtatgcac gggagacttc 1662241 aaatttgacc aaacacctgc acttaatcag acgtgcgaca ttggcgagat cgccaagatc 1662301 ggcaatagcg gcgtgctcgc tctgctttct gacagtgcaa atgcggaacg gccgggttac 1662361 accccttcgg aagcggctgt cagcggagaa atttcggatg cgctgtataa ttcacagaac 1662421 cgggtgatta ttgctgtttt cgcatccaat attaaccgga ttcagcaagt cattcatgca 1662481 gcggctcaaa atggcagaaa gattgccgta gccggaaaaa atcttcaatc tgtcctgcag 1662541 ctggcgagaa agttaggata tattgaagca gatgatgaat tgtttatttc tgtacaggat 1662601 gtcaaaaaat atccgaagcg cgaagtggcc attattacag ccggaagcca aggtgaacca 1662661 ttagctgctt tgacaagaat ggcaaacaaa gctcacaaac agctgaacat tgaagaaggg 1662721 gatacggtgg tcattgcgtc aactccgatt cccgggcagg aactcattta ctctaaaaca 1662781 gtagatcttc ttgcgagagc cggtgcacaa gtcatctttg cccaaaagcg tgttcatgta 1662841 tcaggccacg gctcacaaga agagttaaag ctgatgatca acctgcttaa accaaaatat 1662901 ttgattcctg taaacggcga atacagaatg caaaaagctc attcaaaaat cgctgaagaa 1662961 accggcatga agcgcagtga catcttctta attgaaaaag gcgacgtcgt tgaattccgc 1663021 ggccaaaacg taaaaattgg ggataaagtt ccttacggca atattttaat tgatggttta 1663081 ggtgtcggtg atatcggcaa tatcgtattg agagaccgcc gcttgctttc acaggacgga 1663141 attttaatcg ttgtcattac acttgataaa caaaagaaac atcttgtatc aggaccagaa 1663201 attatcactc gcggctttgt ttatgtaaga gagtctgaag gtcttatcgt acaggctact 1663261 gagcttgtac ggtccatcgt gacagaagcg actgaaacat caaatgtcga atggtcaacg 1663321 ctgaagcagg caatgcggga tgctttgaac caattccttt atgaaaaaac gaaacgtaaa 1663381 ccgatgatca tcccaattat tatggaagta taatgactga ctaaagaccg gagctgctcc 1663441 ggtctttatt ttttgtcctt caagccggga ttgaatgaag tatctttgtt cataatacaa 1663501 agagaaactc ggaaaggatg aaagcgagat ggatcatcgt atggaaaaca cagaagaaga 1663561 gcgtcctgaa aaaaatgatg cgaaggacag cattatgaat aaaatacagc agcttggtga 1663621 aacgacgctt ccgcagctgc cccaagatac aaatattcat tgtctgacca ttatcggaca 1663681 aattgaaggc catgttcagc ttcctccgca aaacaaaaca acaaaatatg aacatgtcat 1663741 cccgcagatt gtggcaattg aacaaaatcc caaaattgaa ggcttgctga tcatattaaa 1663801 tactgtcgga ggagatgttg aagctggtct tgccatagcg gaaatgcttg catctttatc 1663861 gaaaccgacc gtttctatcg tgcttggcgg ggggcattca atcggcgttc cgattgctgt 1663921 atcctgtgat tacagctata tcgccgaaac agcaacgatg acgattcatc cagttaggct 1663981 caccgggctg gtcatcgggg tgccgcaaac gtttgaatac ctggataaga tgcaagaaag 1664041 agttgttaaa tttgtgacaa gccattccaa tataaccgaa gagaagttta aagagctaat 1664101 gttttcaaaa ggaaacttaa cacgcgatat cggaacaaat gtagtcggta aggatgcagt 1664161 taaatacgga ttgatcgatc acgcaggcgg tgtcggacag gcaatcaata aactgaatga 1664221 gctcatcgat gaagcaagga aagaagaagg acggatgatt caatgattct ttataccgtg 1664281 atgcctcagg aaattgtgtt tgcagaacag aaccaagaga caagcgcaca tgagcaaatt 1664341 gaatataaag gtgtaccgct tctagtcgaa atgaaaggga atgaagcgga agtcattcaa 1664401 atcatgagca ccaatccaat gcattttctg catccggaca tttcaccggg acaaaagctg 1664461 aaattaaacg tataagaatc caaccctttt ttaagggcaa aatatgctat aataggggaa 1664521 tcctacagaa aaaacgcagc ctgtaaacgg ctgctttctt cattatgtat gaacttacat 1664581 tttttaacgc agtaaggtga tgagtgtggc aaagaaaaaa cgaaaatcaa gaaaaaaaca 1664641 ggcgaaacag ctcaatataa aatacgagct caacggattg ctgtgtatag ccatttcaat 1664701 tatcgcaatc ttgcagctgg gggtagtcgg gcaaacgttt atctatttgt tccgcttttt 1664761 tgctggagag tggtttattt tatgcttgtt aggtttattg gtgttaggag tctcactgtt 1664821 ttggaagaaa aaaaccccaa gccttttaac gagacgaaag gccgggttgt actgtattat 1664881 cgcaagcata ttgctgcttt ctcacgtgca gctatttaaa aatttgacgc acaaagggtc 1664941 tattgagtct gcaagcgtgg tgcgcaatac gtgggaattg tttttaatgg acatgaatgg 1665001 cagctctgct tcacctgatt taggcggagg gatgatcggt gcgctgctgt ttgcggcttc 1665061 acactttttg tttgcgtcga ctggttctca gatcatggca attgtcatga ttttgatcgg 1665121 aatgatttta gtaacaggac gctcgctgca agaaacgcta aaaaagtgga tgagcccgat 1665181 tggacgtttt ataaaagaac aatggttagc atttattgat gacatgaaat ccttcaaatc 1665241 aaatatgcag tcatcgaaaa aaacgaaagc gccgagcaaa aaacaaaaac cggcccgcaa 1665301 aaaacagcaa atggaaccgg agcctcctga tgaagagggg gattatgaaa cagtatcgcc 1665361 tcttattcat tcagagccga ttatctcaag cttttctgat cgtaatgaag aggaagagtc 1665421 tccagttata gaaaagcgcg ccgaacctgt gtcgaagccg cttcaggaca tccaaccgga 1665481 gacaggtgat caggaaactg tttctgctcc tcctatgacc tttacagagc tcgaaaataa 1665541 ggattacgag atgccgtcac tggatttgct ggcagatccg aagcataccg gccagcaggc 1665601 tgataaaaag aatatttatg aaaatgcgag aaagcttgaa cgcacattcc aaagctttgg 1665661 cgtaaaggcg aaagtcacac aggttcatct cggaccggcc gtaacaaaat atgaagtata 1665721 tcctgatgtc ggagtgaagg ttagcaaaat tgtcaattta agcgatgatt tagcgcttgc 1665781 gcttgctgcg aaggatatca ggatcgaagc gcctatacca ggcaaatcag caatcggaat 1665841 tgaagttcca aacgcagaag tggcaatggt ttcgctgaaa gaagtgctgg agtctaaatt 1665901 gaatgacaga ccggatgcga agctgttaat tggactcggc cgcaatattt caggtgaagc 1665961 tgtattggct gagttaaaca agatgcccca ccttttggtc gcaggcgcaa ccggtagcgg 1666021 gaaaagtgtc tgtgtcaacg gcattattac aagtatttta atgcgggcga aaccgcatga 1666081 agtgaaaatg atgatgatcg atcctaaaat ggtagagcta aatgtctaca acgggattcc 1666141 gcatttgctt gctcctgttg taaccgatcc gaaaaaagcg tcgcaggctt tgaaaaaggt 1666201 tgtcaatgaa atggagcggc ggtacgaatt attttctcat acgggtacaa gaaatattga 1666261 aggatacaat gattatataa aacgcgccaa caatgaagaa ggagcgaaac agccagagct 1666321 gccttatatt gttgtcattg tggacgagct agccgatctc atgatggtcg cttcatctga 1666381 tgtggaagat tcgattacga gattgtccca aatggcgcgg gctgccggca tccatcttat 1666441 tattgcgaca cagcggccat cggtggatgt tatcacaggg gtgatcaaag cgaacattcc 1666501 gtcacgaatc gcgttcagcg tatcttcaca gacggattca aggaccattc ttgacatggg 1666561 tggcgctgag aagcttcttg gccgcggcga tatgctgttt ttacctgtag gggctaacaa 1666621 acctgtccgt gtgcagggag catttttgtc ggatgacgaa gtggagaagg tcgtcgacca 1666681 tgtgattact cagcagaaag cgcaatatca agaagaaatg attcctgagg agacgacgga 1666741 aactcattcc gaggttactg atgaacttta tgatgaagct gttgaattaa tcgtcggcat 1666801 gcagacggca tctgtttcaa tgctgcaaag aagattcaga attggctata cgagagcggc 1666861 gcgcctgatt gacgcaatgg aggaacgcgg tgttgtcgga ccgtatgaag gcagcaaacc 1666921 tagggaagta ttattatcaa aagagaaata tgatgagctc tcttcttaat gaagggagtt 1666981 ccgctttcta tagttgtcaa taatgatatt atgtaaactg atcacctttc tatttatttt 1667041 ttcgacaaaa catgatatag ttgtcccaat tgttcaataa tttttatcga aagtggttta 1667101 cggaggggaa acatgtctac aaaagctgat aatcggcact tgtatttgaa agtaattgaa 1667161 cgaattaaag aggatataaa aaatgggatc tacactgaga aggaaaagct gccttctgaa 1667221 tttgagcttt ccaaaaagct tggtgtcagc agagcgacgc taagagaagc cttgcggata 1667281 ctggaagaag agcatgtgat tatcagaagg catggtgtag gcacttttgt ccattctaag 1667341 ccgttatttc tttcgggtat tgaacagctg aacagtgtaa ccaagatgat agaacaggcg 1667401 aatatgaccc ctggcacgat ttttctatca tcacaagtgc ttatgccgtc tgaagatgat 1667461 acgaagagat ttcacttggc agaagggcaa gaactttttt accttgaacg agtcaggaca 1667521 gctgacggac agccgattgt gtattgtata gacaaaattc cgatgaatat tttgccgaat 1667581 tctttttctc atcagcaaga atctatgttt gacctgctag agaaaaattc aggctccgta 1667641 atcagctatg cagtaactga tatagaaccg atcggctatc acgataccat ttctccagtg 1667701 cttgaatgcg atccggaaac agctcttttg ctgttaaaac aaacccatta cgatcagcac 1667761 gataaaccgg tgctttattc tttaaattat tttagagcgg ataaattcag atttcatgtt 1667821 ttgcgtaaac gattctaaaa acggacgcct gtatgtgtct gtttttttat ttgcactgat 1667881 tcatgtttct ttgtacatac tttcattccg gttaacgcaa tatataaggg atgacaagaa 1667941 agtgaatggg tgaaaatgtt gagagagaaa aatggaatga aaaatattat tgcattgtct 1668001 tctgtcccgc ttgtgatgac actcgggaac tccatgctga ttcctgttct tccgatgatg 1668061 gagaaaaagc tgtctgtgac ttcatttcaa gtatctttaa tcattactgt atattcagta 1668121 gtagcaatta tttgcattcc gattgccgga tatttgtcgg atcgtttcgg gagaaaaaaa 1668181 atattgcttc catgcctcct cattgcagga ttggggggag ccgtagctgc ttttgcctcg 1668241 acctatatga aaaatcctta tgctatgatc ttggcggggc gggttcttca aggcattggt 1668301 tctgcaggtg ccgctccgat tgtcatgccg tttatcggcg acctgtttaa aggagacgat 1668361 gaaaaggtca gcgcgggtct tggcgatatt gaaaccgcca acacgtcagg gaaggtactg 1668421 agtcccatac ttggagcctt actggcttct tggtattggt ttgtaccgtt ttggtttatt 1668481 ccgtttttct gtttgatcag ctttttgctc gtattgtttt tggtggccaa gcctgaagaa 1668541 gatgaagatg cgcctgctgt ttctgagttt attaagagtg tgaagaaaat ttttaaacag 1668601 gatggtcgct ggctttatac ggtcttcatt atcgggtgtg tcattatgtt tttgttattt 1668661 ggcgtattat tttatttatc agatacgctg gagaacaagt atgctattga cggagtagct 1668721 aaaggcggat tactggcaat cccacttttg tttttgtcaa ccagttcttt tatagctggc 1668781 aaaaagatcg gtaaagataa aggccgaatg aaattttgcg ttgttacagg aatgattctg 1668841 ttaacccttt cgtttattgc cttgtggtgg aaccacagtt tttatttttt atttgtcttt 1668901 ttaagctttg gcgggattgg gattggaatg gctcttcctg ctttagatgc attgataacc 1668961 gaagggattg aaagtgaaca atgcggaacc atttcctcct tttacaatag catgcgcttt 1669021 ataggagtag ctctcggtcc acctgttttt gctgcattaa tgtctaatgc aaactggatt 1669081 attttcatac tctcggcgtt ttgcagcatc gtttctttat ttttagtgct ctttactgta 1669141 gatgctaaaa aaagtgaaga agaaaaaaac ttagggacgg tctagccagc cgtctttttt 1669201 tgcgctttct tgcacagttt acaactgtac ctatacagca tgcggaggtt attgtttcct 1669261 tataaatcct acagttgcta taattacatg aaagagtgtt tctgcggatg ctgaaaattg 1669321 gtcataatac atactaatta agaaatgaac gaaggaggtt ccatatgtca tatgttaatg 1669381 aactcaaatc aaagcacggc ggtttaaccg cacacattgt aaaaacagaa aaattcaaaa 1669441 ccgtctcgct tatttttaag atgcttgcgc cgctgacaaa ggatcaagtc accaaaagag 1669501 cgcttctccc gcatgtgctt cttcgcggaa cgaaaagcca tccgaaaacc gcaggattgc 1669561 gttcatactt ggatgagctg tacggcacgt cagtatcggc tgatcttacg aaaaaaggag 1669621 agcggcatgt cattacgttc aggcttgaaa tcccgaatga aaaatattta aaagaccaaa 1669681 cgccgcttct cgagaaaggg ctccagcttc tcgcagaact cgtcttttca cctgctttgg 1669741 agggagacgc ttttcagtca caatatgtgg ctcaagaaaa acggacgctt aagcaaagaa 1669801 tccaagccgt ctatgatgat aaaatgcgtt attcgaattt aaggctgata caggaaatgt 1669861 gcaaaaatga tccttacgcg cttcatgtca atggtgaaat cgacgatgtc gatgacatta 1669921 cggcagagca attatacgaa acataccaaa gcgctatcca aaaagaccag cttgatctat 1669981 atgttgttgg cgacgtggac agtaaccagg tacaatcggc aattgataag tatttcaaaa 1670041 cagaagagcg cactcttggc atgattgaaa acaatcacgc tgatgaaaaa gttcagccaa 1670101 aagaagtaat tgatgaagag gatgtcaagc aaggaaaact gaatatcggc taccgcacca 1670161 gcatcactta tacagatcag gattatcctg ctttacaagt gtttaacgga ttgttcggcg 1670221 gattctctca ttctaaactt ttcattaatg ttcgggaaaa agccagtctt gcttactacg 1670281 cggcttcgcg tatagaaagt tttaaaggct tgttaatggt gatgtcaggc attgaagtga 1670341 aaaattttga acaggcggtt tcgattattg ctgagcaatt ccaggcaatg aaaaatggcg 1670401 atttcagtga gcaggatata gcacagacaa aggccgttat tcgaaatcaa gtgctggaaa 1670461 cgattgatac agcatacggt ttatctgagt ttttatatca gcaggccgct gctcaagtcg 1670521 agattcctat cgaagacttt cttgccaata ttgagaatgt cacaaaagag gatatcatta 1670581 aagccggcga aaagattcag cttgatacga cttatttctt aaaagggacg gagggtgcat 1670641 cttgatcaaa ccaatcgaat atgaacagct tcaggagacg ctgtatcatg aaaaaatgtc 1670701 caacggcctt gatgtttacg ttttgccgaa aaaaggcttc aacaagacat atgcggtctt 1670761 tacaacaaag tacggctcga tagataaccg gtttgtccct ttaggtaaaa acgagatggt 1670821 tcacgtgccg gacgggattg ctcactttct tgagcacaag ctgtttgaga aagcggacgg 1670881 agacgttttt caagatttca gcaaacaggg ggcttctgcc aatgcgttta cgtcatttac 1670941 aagaacggct taccttttct caagcacatc aaatgttgaa cgcaatttag agacgcttat 1671001 cgatttcgta caggacccat attttactga aaaaacggtt gaaaaggaaa aagggattat 1671061 cgggcaggag attaatatgt acgacgataa ccctgattgg aggctttact tcggggtcat 1671121 tgaaaacatg tacaaagagc atcctgtcag aattgacata gcgggaacag tggaaagcat 1671181 ttcacatatt acaaaagacc ttctttatga atgctatgaa acgttttatc acccgagtaa 1671241 catgctcctt ttcattgtcg gccctgtaga tcctgaagcg attatttctc aggtaagaga 1671301 aaaccagggg aaaaagccgt atactgatca gccggagatc aaacgagaag aagtgaaaga 1671361 gcaagaagcg gttttccgaa aagaaaaaga gatcaaaatg aacgtgcagg gaccgaaatg 1671421 ccttgttggg ctgaaatcca aaaatccgtt taaattaggc aaagagctct taaagcatga 1671481 actttcaatg aacttattgc ttgaagctct ttttggcaaa agctctgccc agtatgaatc 1671541 actttatgaa aaaggatata ttgacgaaac gttcagcttt gattttactg ctgaatatgg 1671601 gttcggtttt gcggcgatcg gcggagatac gcctgagcct gatcaattgg ctgaagacat 1671661 ttcaagcatg cttttgcgcg ccggtgaact gattactgct gaaaagattg aacttgccag 1671721 aaagaaaaag atcggcacat tcttaaaagc gctgaattcc cctgaataca tcgccaatca 1671781 atttacccgt tatgcgttct tggatatgag cctgtttgat gttgtaacgg tactcgagca 1671841 gattaccctc gaggatgtcc agaacgtaat acaagaggaa atcgctgcag acagactgac 1671901 tgtctgcaag gttgttccta aatcataaac aaaacatccc tccagtgtga ggggtgtttt 1671961 tctgcggaaa gaaggaaaga ggatgaacaa aacagcacta atcaccggag caagcggcgg 1672021 cattggcaaa agcatcagcg aaacccttgc agctagagga tacaatctgc tgctgcatta 1672081 caatacaaat caaaacgcgg cagcggagct tgctgaaaaa ctaagtcaga tgtttggcgt 1672141 aaatgcggag atattacaag ctgacctgtc cgcgcaagat ggagcagata agctgacaag 1672201 ttcaattgtt cagccgattg atgcgattgt tttaaacagc ggacgaagcc attttgggct 1672261 gattacggat gtagataacg caacggtcca ggaaatggtt cagcttcatg tggcgagtcc 1672321 gtatatgctg acgagaaacc ttctgccagg catgattcgg aataaatcgg gagcgattgt 1672381 ggctgtcagc tcgatttggg gagagactgg agcatcctgt gaagtgttgt acagcatggc 1672441 aaaaggagct cagcattcat ttgtaaaagg attggctaag gagctggcgc caagcggaat 1672501 cagagtaaac gccgtagcgc cgggtgcagt tgatacaaat atgatgaatc aatttacccc 1672561 ggctgaaaaa gaagagatcg ctgatgagat tccgatcggc cggctggccc ggccgcaaga 1672621 aattgcggat gcaacagctt ttctcctgtc tgaaaaagcg tcatatatca ccggccaaat 1672681 tctgtcggtg aatggcggct ggcactgctg atccgaaaat attcggtgta tagtttcttt 1672741 tgcgaaggac acaataatct tgtaacttca catgaaatgg aggaaacaag catgtcagta 1672801 ttagaaaact gggatagctg gaaaaacttc cttggcgacc gtctgaacta tgcgcaagat 1672861 aaaggtatga gccaggatac gattacagat cttgcgacag aaatcggcag ctacttggct 1672921 aatgaagtgg aatctaagaa cgagcaggaa aaagtgctgg cagatctttg gagtgtagca 1672981 tcaaaagatg aacagcacgc cattgccaat atgatggtta agcttgttga aaataacagc 1673041 actcactagg aagagagggg atttttcctc tcttttttat gttttcctca tcacagcaac 1673101 attcttcttt ctaattagag aaaaatgctt tatgataaag gaaggtaaaa ttttgccaca 1673161 atgaaggggg tatatcattt ggcaaagctc gaatggtatt ttgaatatga aattcaagtg 1673221 aaccgccccg gactgctcgg ggatatttca tctcttcttg ggatgctttc tatcaacatc 1673281 gtaacgataa acggcgtcga tctttccaga aggggaatgc tcctcaggtg ccgccatata 1673341 gatcaaatta aacgattaga atcaatctta aaaacgatgg aaacaattaa agtaacgaag 1673401 cttagagaac cgaggcttcg cgaccgtctt gccgtacgcc acggccgtta tattcaacgg 1673461 gatgccgatg acaagaaaac gttccgcttt gaacgggacg agcttggctt attagtcgat 1673521 tttatggccg aattgttcaa aaaagaaggc cataaattaa tcggaatcag aggtatgccg 1673581 cgtgtcggga aaacggaatc gattgtagcc tctagtgtgt gcgagcaaaa ggtggctgtt 1673641 tgtgtcatca accttgctga agcagacgat aagaagccag ctgattgccg atgaatacag 1673701 cactgaaaat gtctttatcg ttgacggaat tgtgtcaaca cgaagagggt cagaacgcca 1673761 tctccagctg gtccgagaaa tcatgcggct gcctgcaaca aaagtggtgg agcatccgga 1673821 catattcgtt caaaatacag agtatacact agatgacttt gattatatta ttgaactgag 1673881 aaatgaccct gatgaggtta ttacatatga acatgccgag gaaccccaaa tgtttgatca 1673941 atccgggttt tcaagctttg atttttaaaa ttggaaggtg tttgttgtga ctgaactagg 1674001 aatccggctc aaagaagcca gagaggaaaa agcaatgtca ttggatgatc tccaagcggc 1674061 aacaaagatt caaaaaaggt atttaaccgc cttggaggaa ggaaactatg acattattcc 1674121 ggggaagttt tatgttcggg cattcatcaa gcaatatgca gaagccgttg ggcttgatgc 1674181 ggatcagctg tttgaggagc ataaaaaaga tatccctaat acgtatcatg atgatgtgtc 1674241 tgaaaagatc tccggcatga atcttcaaaa ggaaatgcca aagccagcat ctaaggcgct 1674301 ggagctgctg ccaacaatac ttgttattct cggcgtgatt gtcgtgattg ccattgtgta 1674361 cgcgatcatt caatttgcca atcacaaaaa cagtgatgat cacaatgcgg catcagaaaa 1674421 agcaattacg caaagtgaga gcaagtacga aatccctaaa gattcaacgc tgaaagagaa 1674481 tcaaaataac agctctgaaa aagagacaga cactaaaaaa gaaacgaaag aaaacgaaga 1674541 taagaaaaaa gaaaatgaca gtgagaagct ggagattaaa gctgctggca ctgaaggatc 1674601 gttaacgact tatgaagtgt ccggcgctga taaaatcgag ctggaactga aggcatcaga 1674661 cagctcctgg attagagtgc gcgatgaaaa cagcagctct ttaaaagaag gaacgctgaa 1674721 aaaagacgaa acctataaaa aagacataac tgatcagaaa caagttgata tccgcaccgg 1674781 atatgcacct aatctgaaaa taaaaatcaa cggtaaggtt ctttcatatg aacttgatcc 1674841 gaaaaaagtg atggcacaaa ccataaagat tgtaaataaa aaggaagaaa agtcatctta 1674901 attaccagat gacttttctt cacgtccgag tatgaaattg gaggggcttt atgtttaact 1674961 taccaaataa aatcacacta gctagaatcg cattaatccc aatcttcatg attatcatgc 1675021 tggcgccgtt tgactggggc aggctcgaag ttggagacga atccatcccg gtcgcacatt 1675081 tggcgggggc cattctattt attattgcat ctacaacaga ctgggtggac gggtattatg 1675141 cccgaaaatt aaatctcgta acaaacttcg ggaaatttct tgatccgctt gcggacaaac 1675201 tgctcgtatc cgcagcgtta attatccttg ttcaatttga tctcgctcca gcttggatgg 1675261 tcattgtgat tatcagcagg gagtttgccg tgacaggttt aaggcttgtc ttagccggaa 1675321 caggagaagt cgtagctgct aacatgcttg gtaaaatcaa aacctgggca cagattattg 1675381 cggtatctgc attgcttctt cataatcttc catttgaact tgtgtcattc ccgtttgcag 1675441 acttggcgct gtgggtagcc gtcttcttta ctgtcgtctc aggctgggaa tatttctcta 1675501 aaaattggga agcgttaaaa acatctaact aagaaagaag gacttcgtca tggaatttcc 1675561 aaaaaaagca gaaataattg cagtcggttc agagttgctg cttggtcaaa tcgccaatac 1675621 aaatgctcaa tttatcagca aacagctcgc tgaaatcggg gtcaacgtat tttatcatac 1675681 agcggtcgga gataacccgg agcggctgaa gcaggtcatc cgcattgctg aagaacgctc 1675741 tgacttcatt attttttcag gagggcttgg acccacaaaa gatgatctga cgaaagaaac 1675801 gattgcaaat acgctgggac gtccgcttgt gttaaatgat gaggcattcc aatccattga 1675861 ggactatttc aaacgaacaa aacgcacgat gtcacctaat aaccgaaaac aggcgcttgt 1675921 gatcgaaggc tctgacgtgc tggcgaatca ctttggaatg gccccgggaa tgctcacaga 1675981 gcatgaatcg cgctattata tgcttcttcc tggaccgccg agcgaattgc gtccaatgtt 1676041 tgaaaacgag gcaaagcctc ttctgctgaa aaagatgggt tcaaatgaaa aaattgtgtc 1676101 aactgttctt cgctttttcg gtatcggtga atctcagctt gaagccgatt tggaagatat 1676161 tattgatgca caaaccaatc cgacaattgc gcctttggcg gctgatggag aggtgacgct 1676221 gcgtctgaca gccaaacacg ccgatgaaaa ggaaacagag cgtctgttaa aagaaacaga 1676281 ggccgttatc ttagagcgtg tcggtgaatt tttctatggt tacgatgata cttctcttgt 1676341 aaaagagcta tctatagcat gtaaggaaaa aggcataaca atttctgcgg cagaaagctt 1676401 taccggaggg ctgttttctg aatggctgac ggatcatagc ggtgcctcaa aattatttgc 1676461 cgggggcgtt gtttgctata caaacgacgt gaagcagaat gtgcttggtg tcaagaagga 1676521 aacattagat cgttttgggg cggtcagcaa ggagtgcgca tccgaactgg ctaagggtgt 1676581 tcaaaaactc actggcagcg atatcggcat tagctttact ggtgtagcag gacctgatgc 1676641 tcaagaaggg catgagcctg ggcatgtgtt tatcggcatt tccgcaaatg gtaaagaaga 1676701 ggttcacgag tttcactttg cgggctccag aacggggatc agaaaacgcg gcgctaaata 1676761 cggctgccat ttaatcttaa agcttttaga gcaaaaataa tattttcagc acattatcct 1676821 cctaagaaaa catgatttct ctgatacatt atgatatttt gataggaatc acgccaagaa 1676881 aaaatccgaa tatgcgttcg cttttttctt ggcaaatccc ttcaaacagg gtatagtata 1676941 tgtagtggta acataaagga ggaaaaaata gaatgagtga tcgtcaggca gccttagata 1677001 tggctcttaa acaaatagaa aaacagttcg gcaaaggttc cattatgaaa ctgggagaaa 1677061 agacagatac aagaatttct actgtaccaa gcggctccct cgctcttgat acagcactgg 1677121 gaattggcgg atatcctcgc ggacggatta ttgaagtata cggtcctgaa agctcaggta 1677181 aaacaactgt ggcgcttcat gcgattgctg aagttcagca gcagggcgga caagccgcgt 1677241 ttatcgatgc ggagcatgcg ttagatccgg tatacgcgca aaagctcggt gttaacatcg 1677301 aagagctttt actgtctcag cctgacacag gcgagcaggc gcttgaaatt gcggaagcat 1677361 tggttcgaag cggggcagtt gacattgtcg ttgtcgactc tgtagccgct ctcgttccga 1677421 aagcggaaat tgaaggcgac atgggagatt cgcatgtcgg tttacaagca cgcttaatgt 1677481 ctcaagcgct tcgtaagctt tcaggggcca ttaacaaatc gaagacaatc gcgattttca 1677541 ttaaccaaat tcgtgaaaaa gtcggtgtta tgttcgggaa cccggaaaca acacctggcg 1677601 gccgtgcgtt gaaattctat tcttccgtgc gtcttgaagt gcgccgtgct gaacagctga 1677661 aacaaggcaa cgacgtaatg gggaacaaaa cgaaaatcaa agtcgtgaaa aacaaggtgg 1677721 ctccgccgtt ccgtacagcc gaggttgaca ttatgtacgg agaaggcatt tcaaaagaag 1677781 gcgaaatcat tgatctagga actgaacttg atatcgtgca aaaaagcggt tcatggtact 1677841 cttatgaaga agagcgtctt ggccaaggcc gtgaaaatgc aaaacaattc ctgaaagaaa 1677901 ataaagatat catgctgatg atccaggagc aaattcgcga acattacggc ttggataata 1677961 acggagtagt gcagcagcaa gctgaagaga cacaagaaga actcgaattt gaagaataaa 1678021 aataaaataa gtttcaaatg atacaaaagg ctgagtgaaa aactcagctt ttttgtattt 1678081 tgcaaaaaaa tgataaaaat attgcttttt ttgacaactt ttttagggct ttattcgtct 1678141 aacaaaacgt gtgcaaaatg gaatttattt tgggaggaaa aaatgaatga caagcccaac 1678201 ccgcagaaga actgcgaaac gcagacggag aaaactaaat aaaagaggaa aactgttgtt 1678261 tggtctttta gcagtgatgg tttgcattac gatttggaat gctcttcatc gaaatagtga 1678321 agaaaacgaa ccatctcaag aaactgcagc ggtttcaaat accgatcaga aaaaagaggt 1678381 caaaaagaaa actgccaaaa aatcagagga acaaatcaaa acagtggatc gaaaccaaaa 1678441 aatcagcaat tatttaaaag agatcggttt cagcggaaca gccatgattg tcagaaatgg 1678501 agaaatcgta acaaataaag gttttggcta tgctgaccgt aaacactaca ttcaaaataa 1678561 tccattgaca tctttttatg tcggttcatc acaaaaagcg ctgattgcaa ctgctatttt 1678621 gcagcttgag gaaaagggga aacttcagac aagtgatccg gtaagcacgt atttacctca 1678681 ttttcccaac ggacaaacga ttactttgaa gaatctgctt acacatacat cggggataaa 1678741 cggacatatt gaaggaaacg gcgccattac tccggacgat ttaataaaag atatagaact 1678801 tcagggaatc aaacgtcagc cgggcgtatg ggactacaag gattccaact attctgttct 1678861 tgcttatatt attgctgaag taagcggtga gccctatgaa cagtacataa agaatcatat 1678921 ttttaaacct gcgggaatga cgcatgcagg cttttacaaa acatatgaaa aagaacctta 1678981 tcctgccgtc gggtataaga tggagggcag caaaacagtt acaccgtata tacctgattt 1679041 atcccagctg tatggagcgg gtgatattta tatgagcgct atagatatgt acaaatttga 1679101 ccaagcgctg atagacggaa aactgtattc gcaaaaaagc tatgaaaaga tgtttacgcc 1679161 agggagcagc tccacatacg gcatgggatt ttatgttgct cccggaagct attcaaacca 1679221 tggtgttatg ccgggcttca atatcttgaa cagctttagc aaatctgggc aaaccattgt 1679281 tattttgttc tcaaacattc aaaataatgc taaattgggc caagtgaaca ataaaatata 1679341 ccagcttcta aatcaagaat gattggcgat cttcttttgg atgaattgca ttcggcacgt 1679401 gaaaagaaga ctggcctgca aacgttaaga tggcaagctt gacaagtatt tccgacacat 1679461 ttacaatgaa gttgtaacat ttgttttttt aacatgattg ttaaaccatt taaacttgac 1679521 aagggcgatg aacacactca ttccctgtga aggttctgta tgttgagaaa actagacaat 1679581 gtacatgccg acacttttta agcaacaacc aagttcatag caagaggagg tgaaagtatg 1679641 accccaatta tgatggttct catctccatt ttgctgattc tactcggttt agttgttggc 1679701 tactttgttc gtaaaaccat tgccgaagcg aaaattgcgg gcgcacgcgg tgcagccgag 1679761 caaattcttg aagatgcgaa gcgtgatgct gaagcactga aaaaagaagc tctgcttgaa 1679821 gcaaaggatg aaatccacaa acttcgaata gatgctgaac aggaagttcg tgaaagacga 1679881 aatgagcttc aaaaacaaga aaaccgttta ctccaaaagg aggaaaacct tgatcgcaaa 1679941 catgagggaa ttgataaacg ggaagcgatg ttggagaaga aagatcattc tctgaatgaa 1680001 cgacaacaac atattgaaga gatggaaagc aaagtggatg agatgattcg tatgcagcag 1680061 tctgagttgg aacgaatttc gagtctgact cgtgacgaag cgaaacaaat cattcttgag 1680121 cgggttgaaa acgagctttc acatgacatc gccatcatga caaaagaaac tgaaaaccgt 1680181 gcgaaagaag aggcggataa gaaagcgaaa aacattcttt cactcgcctt acagcgctgc 1680241 gcagcggacc acgttgccga aacaacggta tcagttgtca atcttccaaa tgatgagatg 1680301 aaaggacgta tcatcggacg ggaagggcgt aacattcgta cgcttgaaac gctgacagga 1680361 attgacctga ttattgatga tacgcctgaa gctgtcattc tttccggatt tgatccgatc 1680421 agacgtgaga cagccagaat tgctcttgat aaactcgttc aggatggccg tattcatccg 1680481 gcacggattg aagaaatggt tgaaaaatct cgccgcgagg tcgatgacta tattcgtgag 1680541 atgggtgagc aaacgacatt tgaggttggc gttcatggcc tccacccaga tctcatcaag 1680601 atcctcggcc gcttaaagtt ccgtacaagc tacggtcaaa atgtgcttaa gcattccatg 1680661 gaagtcgcat tcttggccgg tctaatggca tcggagcttg gtgaagacgc aaagcttgct 1680721 aaacgtgcgg gtcttcttca cgacatcggg aaagcaattg accatgaagt agaaggaagc 1680781 cacgttgaga tcggggtaga gcttgcgacc aaatataaag agcacccagt cgtgattaac 1680841 agtattgcat cacaccacgg ggacgaggag ccgacttcca ttattgctgt actggtagct 1680901 gcagcagatg cgctttccgc tgcaagacct ggcgcaagaa gtgagacgct cgagaattat 1680961 attcgaagac ttgaaaaact tgaagaaatt tctgagtcct acgaaggtgt tgaaaaatca 1681021 tttgccattc aggctggacg cgaagtgcga attatggtga agccggattc aattaatgat 1681081 cttgaggctc atcgactggc gcgagatatc cgcaagcgaa ttgaggacga gctcgattat 1681141 ccaggtcata ttaaggtgac agtaatcaga gagactcgag ccgtagagta tgcaaaataa 1681201 agtgatgcgc taagcatcac tttatttttt tgacggcaag gaattttcaa gaagaaagga 1681261 tttacaaaat gagaatttta tttatcggag atgttgtcgg ttcaccgggc cgtgacatgg 1681321 tcaaagaata tgtaccaaag ctaaaaacaa aatataagcc tcactttacc attattaatg 1681381 gtgaaaacgc cgcacatgga aaaggcctga cggaaaaaat ttatcacagc ttaatccagt 1681441 ccggcgcaga tgcaatcaca atggggaacc acacatggga caaaaaagaa atatttgatt 1681501 ttatagatga cgttccgaac ttggttcgcc cggcaaactt tcctgaagga acaccgggga 1681561 aagggatcac atatgtgaaa gcaaacggca aagaactagc agtcattaat ttgcagggac 1681621 gtacgttttt gccgccgctt gatgacccgt ttttaaaagc ggatgaattg atcgcagaag 1681681 ctgcgaaaag aacaccgtac atttttattg actttcatgc cgaagcgaca agtgaaaagc 1681741 tcgcacttgg ctggtacacg gatggacggg catcggctgt agtaggaact catacacacg 1681801 tgcaaacagc ggataaccgc attttgccga agggaacggc atatattact gatgtgggaa 1681861 tgactggccc gtatgacggt atactgggga tggacagaga gacgattatt aagcgattca 1681921 aaacgaacct tccagtccgg tttactgtcg ctgaaggaaa aacaacgctc agcggagttg 1681981 tcattgacat tgacgatcaa acgaaaaaag ccgtgaaaat tgagcgtatt ttaatcaacg 1682041 atgatcacat gttctttgaa tagttgaaca tatggttatt ttataaaaat attaaaaaga 1682101 aaagcaggaa tatagcaact ccttagtgaa tatagtaaaa atggaaggta gcccgctatt 1682161 tttgaaaagc attgtgggga tggctttttg gatagcaaca tctaataatg attgttctaa 1682221 tgaacactca cttatccatt gtaaaactaa gggggagcag aaatggaaat cttaaaagtt 1682281 tcagcaaaat cgagtccaaa ttcagtggca ggtgcgcttg caggcgtgtt gagagagcga 1682341 ggagccgccg agattcaagc gatcggagcg ggtgcattaa accaggctgt aaaagctgtg 1682401 gcgattgcca ggggatttgt ggcgccaagc ggcgttgatt tgatttgtat tccggctttt 1682461 acagatattc aaatcgatgg ggaagaaaga acagcgatta aattaatcgt ggagcctcgc 1682521 taaaaacaaa taaagcattc tcaacctgtt tgcgtaatgc aaacaggttg tttttcattt 1682581 attgtgatat tttctcccga tagtattttt agcacataaa tgagcgaata tacaaaatca 1682641 gaaatgagct aaaacgtttc aaaaaaaatt tccgcccatt tttcaagaca gatacttttg 1682701 tccttctgga aaagacagtt ctgtttacgc ttattccata tcatggtaca atccgaatat 1682761 aacaagaatt tttcaaggag gattgtacat gcagagtgga aagatgaaag ctctaatgaa 1682821 aaaggacggg gcgttcggtg ctgtgctgac tgaagttccc attcctgaga ttgataaaca 1682881 tgaagtcctc ataaaagtga aagccgcttc catatgcggc acggatgtcc acatttataa 1682941 ttgggatcaa tgggcacgtc agagaatcaa aacaccctat gttttcggcc atgagttcag 1683001 cggcatcgta gagggcgtgg gagagaatgt cagcagtgta aaagtgggag agtatgtgtc 1683061 tgcggaaaca cacattgtct gtggtgaatg tgtcccttgc ctaacaggaa aatctcatgt 1683121 gtgtaccaat actgctataa tcggagtgga cacggcaggc tgttttgcgg agtatgtaaa 1683181 agttccagct gataacattt ggagaaatcc cgctgatatg gacccgtcga ttgcttccat 1683241 tcaagagcct ttaggaaatg cagttcatac cgtactcgag agccagcctg caggaggaac 1683301 gactgcagtc attggatgcg gaccgattgg tcttatggct gttgcggttg caaaagcagc 1683361 aggagcttct caggtgatag cgattgataa gaatgaatac aggctgaggc ttgcaaaaca 1683421 aatgggagcg acttgtactg tttctattga aaaagaagac ccgctcaaaa ttgtaagcgc 1683481 tttaacgagt ggagaaggag cagatcttgt ttgtgagatg tcgggccatc cctcagcgat 1683541 tgcccaaggt cttgcgatgg ctgcgaatgg cggaagattt catattctca gcttgccgga 1683601 acatccggtg acaattgatt tgacgaataa agtggtattt aaagggctta ccatccaagg 1683661 aatcacagga agaaaaatgt tttcaacatg gcgccaggtg tctcagttga tcagttcaaa 1683721 catgatcgat cttgcacctg ttattaccca tcagtttcca ttagaggagt ttgaaaaagg 1683781 tttcgaactg atgagaagcg ggcagtgcgg aaaagtaatt ttaattccat aaagggggat 1683841 aaacatgacg aaggaatttg agtttttaaa agcagagctt aatagtatga aagaaaacca 1683901 tacatggcaa gacataaaac agcttgaatc tatgcagggc ccatctgtca cagtgaatca 1683961 ccaaaaagtc attcagctat cttctaataa ttacctcgga ttcacttcac atcctagact 1684021 catcaacgcc gcacaggagg ccgttcagca gtatggagcc ggcaccggat cagtgagaac 1684081 gattgcgggt acatttacaa tgcatcaaga gcttgagaaa aagctggcag cctttaaaaa 1684141 aacggaggcg gcacttgtat tccaatcagg cttcacaaca aaccaaggcg tactttcaag 1684201 tattctatca aaagaggaca ttgtcatctc agatgaattg aaccatgcct ctattattga 1684261 cggaattcga ctgacaaagg cggataaaaa ggtgtatcag cacgtcaata tgagtgattt 1684321 agagcgggtg ctgagaaagt caatgaatta tcggatgcgt ctgattgtga cagacggcgt 1684381 attttccatg gatggcaaca tagctcctct gcctgatatt gtagagctcg ctgagaaata 1684441 tgacgcattt gtgatggtgg atgacgccca tgcatccgga gtacttggcg aaaacggcag 1684501 gggaacggtg aatcacttcg gtcttgacgg cagagtgcat attcaggtcg gaacattaag 1684561 caaggcaatc ggagtgctcg gcggctacgc tgcaggttca aaggtgctga tcgattattt 1684621 gcgccataaa ggccgtccat ttttattcag cacatctcat ccgccggcag tcactgcagc 1684681 ttgtatggaa gcgattgatg tcttgcttga agagccggag catatggagc gcttgtggga 1684741 gaatactgcc tattttaaag caatgcttgt gaaaatgggt ctgactctca cgaagagtga 1684801 aacgccgatt cttcctattt taataggtga tgaaggtgtg gcaaagcaat tttcagatca 1684861 gctcctttct cgcggtgttt ttgcccaaag tatcgttttc ccgactgtag caaagggaaa 1684921 agccagaatt cgcacgatta taacagcaga gcacaccaaa gatgaactgg atcaggcgct 1684981 tgatgtcatc gaaaagacgg caaaggagct ccagctattg taacaagagg aagagtttac 1685041 tcttcctctt ttgattcctt attgattatt attctcaatg agtgtacaat gataggttgc 1685101 cagttgtgca gagcttcaat aacctttata ctgaagggtg gaagtttggt ttgaaaggag 1685161 aaaatatgac atgaatgaaa aacaaaaatt agagagcgga caagttcatc catcggacaa 1685221 aaaatccgag aaggattaca gcaagtactt tgaagctgtt tacattccgc cttctttaaa 1685281 agacgcgaaa aaacgaggca aggaagccgt tacttatcat aatgacttta aaatttctga 1685341 acaatttaaa ggattgggag acggaagaaa gttctatatc cgtacgtacg gctgccaaat 1685401 gaatgaacac gatacagagg ttatggcagg gatctttatg gcgctcggtt acgaagcgac 1685461 aaactctgtt gacgatgcca atgtcatttt gttaaataca tgtgcaatcc gtgaaaatgc 1685521 tgaaaacaag gtgtttggtg agctcgggca cttaaaagca ctgaaaaaaa acaatcccga 1685581 tctgatttta ggcgtgtgcg gctgtatgtc ccaagaggaa tcagtcgtga accgtatttt 1685641 gaaaaaacat ccgtttgtcg atatgatttt cggaacgcat aacattcatc gcctgccgga 1685701 gcttttgtca gaagcatacc tttcaaaaga aatggttgta gaagtttggt ctaaggaagg 1685761 ggacgttatt gaaaaccttc caaaagtccg aaatggaaaa attaagggct gggtcaatat 1685821 catgtacggc tgtgacaaat tctgtacgta ttgcattgtg ccttacacac gcggaaaaga 1685881 aagaagccgc cgccctgagg atatcattca ggaagtgaga aggctcgcaa gtgaaggcta 1685941 taaggaaatt actctgttag gccaaaacgt aaacgcgtat ggaaaagact ttgaagatat 1686001 gacgtacgga cttggtgatt tgatggatga actgagaaaa atcgatatcc cgagaatccg 1686061 ttttacaacg agtcatccgc gcgactttga cgaccgcctc attgaagtgc tggcaaaagg 1686121 cggaaatctg cttgatcaca ttcatcttcc ggttcaatca ggaagctcag aagttctcaa 1686181 gctgatggcc cgcaaatatg acagagagcg ttacatggag ctggtgcgaa aaattaaaga 1686241 agcaatgcca aacgcttctt tgacaacgga cattatcgtc ggatttccaa atgaaacgga 1686301 cgaacagttt gaagaaacgc tttctctata ccgtgaagtg gagtttgaca gcgcctatac 1686361 gttcatttac tctccgcgtg aaggcactcc ggctgctaag atgaaagata atgtaccgat 1686421 gcgtgtgaaa aaagaacgcc tgcagcgtct aaacgcactg gtgaatgaaa tttctgctaa 1686481 aaaaatgaag gaatacgaag gcaaggttgt cgaagtatta gttgagggtg aaagcaaaaa 1686541 taaccctgat attcttgctg gctatactga aaaaagcaag cttgtcaatt tcaaagggcc 1686601 gaaggaagcc atcggcaaaa tcgtccgcgt gaaaatccag caagcgaaaa catggtcgct 1686661 tgacggagaa atggtaggag aagcaatcga ggtgaaatga gatgacgctc tactcaaaaa 1686721 aagacattgt gcagcaggct cgaaaccttg caaaaatgat ttctgaaaca gaagaggttg 1686781 attttttcaa acgggctgaa gcgcaaatca atgagaatga caaagtgtcc acaatcgtta 1686841 atcagattaa agccctgcaa aagcaggctg tcaatctgaa gcattatgaa aagcatgaag 1686901 cgctcaaaca agtagaagca aaaattgacg cgctgcaaga agagcttgaa gagattcctg 1686961 ttatccagga attcagagac tcgcaaatgg aagtaaatga cctactgcag ctcgttgcac 1687021 acaccatttc caaccaagtc acaaatgaaa tcatcacatc aaccggaggc gacctgctga 1687081 aaggggaaac cggttcaaag gtgaagcatt caaataacag ctgttctctc taaacacggt 1687141 gcctttacag gcccgtgttt ttttatcatt tgtgcggtta aaaatgaact aaataatcta 1687201 tgtaccaaat gttcaattgg tttttctgtg ctcagccgcg tataaacttt atcgcactta 1687261 taagtaaagt ttctaggcac ccctgcatac aatggaacag aaactttgta tttttatatt 1687321 ttatttataa aaatgcacac tagacaaatg cccagcataa gataacacga agaagaacaa 1687381 ggaggcatgc cggaatgtct gaatacaggg aaattattac gaaggcagta gtagcgaaag 1687441 gccgaaaatt cacccaatgc accaacacca tctcgcctga gaaaaaaccg agcagcattt 1687501 tgggtggttg gattattaac cacaagtatg acgctgaaaa aattggaaaa acggtagaaa 1687561 ttgaagggta ttatgatata aacgtatggt actcttacgc ggacaacaca aagacagagg 1687621 ttgtcacaga acgggtaaaa tatgtagatg tcattaaact cagatacaga gacaataatt 1687681 acttagatga tgagcatgaa gtgattgcca aagtgcttca gcagccaaac tgccttgaag 1687741 tgaccatttc gccgaatgga aataaaatcg ttgtgcaggc agaaagagaa tttttggcgg 1687801 aagtggtagg ggaaacaaag gtagttgttg aggtcaatcc tgactgggaa gaggatgacg 1687861 aggaagattg ggaagatgag cttgatgaag agcttgaaga catcaacccg gagtttttag 1687921 tgggagatcc tgaagaataa aaaagggact aggggagaca gtacccccaa gtctcttttt 1687981 tatattgata tatcattctt ttatcacttt ttgtttatgt tataatgaag gttggaaaat 1688041 agaaacgttg atacatagtg agggattaaa caatggccgg ttatacgcct atgatacagc 1688101 aatatttaaa aataaaggca gagcaccagg atgccttttt attttttcgc ctgggtgatt 1688161 tttatgaaat gttttttgag gacgccaaaa aagcgtcaca agagctggaa attacgttaa 1688221 cgagcagaga cggcggtgcg gctgaaaaaa taccgatgtg cggtgtgccg tatcattctg 1688281 cttccgcgta tatcgaacag cttattaaaa aaggatacaa agtggcgatc tgtgaacaga 1688341 cggaagatcc gaaagccgca aagggcgttg tgaaaagaga agtagttcag ctgattacgc 1688401 ccggaactgt aatggacggc aaaggcatcc atgagtcgga aaataatttt atcgcatctg 1688461 tttcagcctg ctcgaacgga tacggacttg ctctgtctga tttaacaacg ggagaaaatt 1688521 tggctgtttt gattgaacgg cttgaagacg tcatatcaga aatttattca gtcggcgcac 1688581 gggaaatcgt ggtttcagga agcttggatg ccgatacagt ggcacagctg agagagcggt 1688641 gcggtgcaac gatttcaatt gaagacggag aaacagacga acacgtaacg atcattgagc 1688701 acttaaataa tgaagatata acaaaaacat ttctgcgctt atatacgtat ttgaaaagaa 1688761 cccaaaagcg cagccttgat catcttcagc ccgtgcaggt gtatgagctt gaggaagcga 1688821 tgaaaattga cttgtactca aagcgtaatc tggagctgac cgaaacgatt cgttcgaaaa 1688881 ataaaaaagg ctcccttttg tggctgctgg atgaaacaaa aacggcaatg ggaggccggc 1688941 tacttaaaca gtggattgac cggccgctta tcagagtcaa tcaaatcgaa gagcgccaag 1689001 aaatggtgga aacattaatg tcccatttct ttgaacggga agatctgcgt gaacgtttaa 1689061 aagaagtata tgacttagaa cgccttgccg gccgcgttgc attcggaaat gtcaatgccc 1689121 gggatttgat tcagctgaag gaatcgttaa agcaagtgcc tggcatcaaa cagctggttg 1689181 cttcactggc tcatgacaag gccaaggaac gtgcaaagcg cattgaccct tgcggggatg 1689241 tacttgaact gctggaagaa gcgctgtacg aaaaccctcc tttatcggta aaagaaggga 1689301 acctgattaa agatggttat aatcaaaagc ttgatgaata tcgtgatgca agcagaaacg 1689361 gaaaagactg gattgcccgc ctggaacagc aggagcggga atacacaggc attcgctctt 1689421 taaaggtcgg ctttaataaa gttttcggtt attacattga agtgacaaaa gcaaacttgc 1689481 atttgcttga ggaagggcgt tatgagcgga agcagacgtt aaccaatgca gagcgctaca 1689541 ttacacctga attaaaagaa aaagaagcgc tcattttaga ggcggaaaat aacatctgtg 1689601 agctggagta cgagctgttt accgagctgc gcgagaaagt gaagcagtat attccgcggc 1689661 tgcagcagct tgcaaaacag atgagcgagc tggacgcact gcaatgcttt gcgacaatca 1689721 gtgaaaatcg ccactacacg aaaccagagt tctctaaaga tgaagtcgaa gtgattgaag 1689781 gcagacaccc ggttgttgaa aaagtcatgg acagccagga atatgtcccg aacaactgta 1689841 tgatgggcga taacagacaa atgcttctca ttacaggtcc aaacatgtca gggaaaagca 1689901 cgtatatgag acaaatcgcg ctcatttcca ttatggcgca aatcggctgc tttgtacccg 1689961 cgaaaaaagc ggtgctcccg attttcgatc aaatttttac gcgaatcggc gctgcagatg 1690021 atttgatttc cggacaaagt acatttatgg tagaaatgct tgaagcgaaa aatgcgattg 1690081 tcaatgcgac gaaaaacagc ctcattctgt ttgatgaaat cgggcgggga acgtccactt 1690141 atgacggcat ggcgctggca caggcgatta ttgaatatgt tcacgatcat atcggcgcca 1690201 agacgctgtt cagcacacac tatcacgagc tgaccgttct tgaggacaag ctgccccagc 1690261 tgaaaaacgt tcatgttcgc gctgaagaat ataacggaac ggttgtcttt cttcatcaaa 1690321 ttaaagaagg tgcggctgat aaaagctatg gtatccatgt agctcagctt gccgaactgc 1690381 cgggagatct gattgcgcgc gctcaagata ttttaaaaga gcttgagcat tcaggaaaca 1690441 aaccggaagt gccggtgcag aaacctcagg tgaaagaaga gccggcacag ctgtcctttt 1690501 ttgacgaagc ggaaaagccg gctgaaacac caaagctttc aaaaaaagaa aagcaagtga 1690561 tcgatgcttt caaatcactt aatatactgg atatgacacc gcttgaagcg atgaatgaaa 1690621 tgtacaagct gcaaaagaaa ttacattaaa acggggtgat gaatgtggca aaagtcatcc 1690681 aactgtcaga tgagctttca aataaaatag cggcgggcga ggttgtggaa cggcccgcct 1690741 cagtcgtcaa agaattggtg gaaaatgcga tcgacgctga cagcacagtc attgaaatcg 1690801 atattgagga agcaggcctt gcatccattc gggtcttgga taacggcgaa ggaatggaga 1690861 atgaagattg caagcgagct ttccggcgcc acgcaacgag taaaataaaa gatgaaaatg 1690921 atttattcag ggtgagaacg ctcggtttca ggggagaagc cctgccgagt atcgcgtcag 1690981 tctctcatct ggagattaca acaagcactg gtgaaggagc tgggacgaag ctcgtcctcc 1691041 aaggaggaaa catcatttcc gaatcgcgtt cctcaagcag gaagggaact gaaattgtcg 1691101 tttccaacct gttttttaac acaccggccc gtttgaaata tatgaaaacc gttcatacag 1691161 agcttggaaa cattacagat gtggttaacc gtattgctct ggcgcatcca gaggtatcga 1691221 tccgcctgcg ccatcatggg aaaaacctgc ttcaaacgaa cggaaacgga gatgtgcgcc 1691281 atgtactggc agcgatttac ggcacggctg tcgccaaaaa aatgcttccg ctgcatgtga 1691341 gctccttgga ttttgaagta aagggatata tcgccctccc agagattaca cgggcgtcga 1691401 gaaactatat gtcgtctgtg gtcaatggcc gttacattaa aaatttcccg ctcgtcaaag 1691461 cggttcatga aggctatcat acgcttctgc cgatcggacg ccatccgatt acttttatag 1691521 aaattacgat ggacccgatt ttagtcgatg tcaacgtgca tccatcgaag cttgaggtcc 1691581 ggctcagcaa ggaaacagag cttcatgact taatacgtga cggaattaaa gatgtgttta 1691641 aacagcagca gctgattcct agtgcccagg tcccgaaaaa atcagcacct gccatcaaaa 1691701 atgagcagca gtttataacc tttgatgaaa agcctccgga aaaaaaagtt ccggaaaaat 1691761 cgactgcgcc atcttattca ccgatgaagc tcagctcagt cgtaaaagag ccggttgatg 1691821 cggaggaaaa attgccccct ctccaatttg atgctcctcc tatcgttgat caggaacaaa 1691881 cccttgaggt gtccgatgtt tcagcagaac agcctgaaac atttgagcag gaatgccatg 1691941 aggaacagcc gcagccagcg tctgatcggg ttccaattat gtacccgatt ggccagatgc 1692001 acgggactta tatattggca caaaacgaaa acggcctata tattatcgac cagcacgccg 1692061 cccaagaacg tattaaatat gagtacttcc gtgaaaaggt gggggaggtt gagcctgagg 1692121 tgcaggagat gattgtaccg ctgacgttcc actactccac aaatgaggct ttgattattg 1692181 aacagcacaa acaagagctc gaaagcgtcg gtgtcttttt agagtcattc ggctctaaca 1692241 gttacatcgt ccgctgccac ccagcctggt ttccaaaggg agaagaagca gagcttatag 1692301 aagaaatcat tcagcaggtg ctcgactcca aaaatataga tattaaaaaa cttcgcgagg 1692361 aagcggcgat tatgatgagc tgcaaaggct ccatcaaagc aaatcgccac ctcagaaacg 1692421 acgaaatcaa agcgcttctg gacgacctcc gaagcacatc agacccattt acatgcccgc 1692481 acggccgccc gatcatcatt caccactcga catatgagat ggaaaagatg ttcaaacgcg 1692541 tgatgtagcg ggggtggtag gcattgatcc attctctgaa tggatcaatg ctttttttgt 1692601 actccttcga gtgtcagatt ataagaaacg gttgtaaacg tgtgagcagt gttaacgcat 1692661 tatacttcat ggttcctccg tataacaaaa tttccattta caggcaattg ggattaatgt 1692721 atattttggg tgagggggtg gaaacatatg gcatgtggtc cgaagatcat tatctttttg 1692781 gatgaacttg atgatccaaa tgtgagaatc attttagaat gcagaattta aattacaaca 1692841 ttgtgttttg ctccctgttc gtgtgaacag ggagattttt tcgtttatat aactggtgat 1692901 gtccaaatat agggtgttat gaattttcca tatctgccat cggctttaag ctgcttctct 1692961 attaggctgg ttatcaaaag caagttcaat gatagccatg aaagctgata tcacaacaag 1693021 caagacatct ggaatataaa tagactgcat aaagtaatct gcaaaacaga tcgttataag 1693081 attgctgata aaatacagta taaaagcaaa aagtgcagtc tttttcaatg aaagtgattt 1693141 tgccaaaatg atagagataa tctttgtgag tgggtctatg attaaaccta cagcaaagca 1693201 ggctaaaata aataaagcta atgtttgatt ggaagcgtat gtgatgccaa gtatggagaa 1693261 taagcctttc atcccgaaga aaaagccgcc gaagatgact gcaagcgcga tggccgcgat 1693321 aaaagtaata gatacaattc cgattaattt tgatctcagg ttaaaatctt tagagtgctc 1693381 gttctgttct ttttggttca tgtatgacac tcccttcacc tgcttactca tacaaacagc 1693441 acccttgaat cagcccaaaa tatctataag tctgttttct gacgaaaata gtatagcata 1693501 ttttaacaaa accaaaaaag gccctttcca ctggggaagg gcctttttca tcatgttaac 1693561 tcctgagatt cgccgaagct ttctcttttt ttggccaaat aaaatagctg gctgtaatga 1693621 gaaagtcaat gcctataatg acagtccaca gtttaagaat gccgctcaac gcctcggttc 1693681 gggaagagtc attgataaaa tagatcatcc ctgccaatag tcccgcacca attaagtagg 1693741 ccagcacatg tcttagccag cctttcgcac cgtgcttggc atggtccatt ccaaaacgtt 1693801 tcagcggttt tgttcctttt tttgtcacat aatattgaaa cttttcatct gcccattgaa 1693861 tcatttgttt cccataagcg atcgatatac cgatgtaaac agctgcaatc ccatgggctg 1693921 cggtcgctga ggctccgcgg taaaggtcca caccagttgc cgctaacaag atcaaatcga 1693981 taactggagt taaggcaagg aatagcagtc ctaatgtatg tcgtttgaat acgtagcgta 1694041 cagcaagccc caaaacaatg acaacccaaa acgcaatttc acagaaaaca atcatccatg 1694101 cgataccgtt caatccattc ccctcttttc aatacagttg tattatttaa ataatatgtt 1694161 accatctttg tttttgtaac acaactgtat tataaaaatt gccctctcat ttttttcttg 1694221 ttacaataaa gctatgccaa aacaaattga ccatgagaaa agaagaaaac aaattgcaga 1694281 agcaacgtgg cgcgtcattt tagaacgagg gatggaggga gcatcagcca gaaatattgc 1694341 aaaggaagct ggattgtcat tagaagcttg atcggcaata gttaccctta ttatcaagat 1694401 aagaaagaaa aggatttttc gctacgctca aatcctttaa aaaaacacaa aagaccacat 1694461 tttttaatgt ggtcttttat tcttcaacta aagcacccat tagttcaaca aacgaaaatt 1694521 ggataaagtg ggatattttt aaaatatata tttatgttac agtaatattg acttttaaaa 1694581 aaggattgat tctaatgaag aaagcagaca agtaagcctc ctaaattcac tttagataaa 1694641 aatttaggag gcatatcaaa tgaactttaa taaaattgat ttagacaatt ggaagagaaa 1694701 agagatattt aatcattatt tgaaccaaca aacgactttt agtataacca cagaaattga 1694761 tattagtgtt ttataccgaa acataaaaca agaaggatat aaattttacc ctgcatttat 1694821 tttcttagtg acaagggtga taaactcaaa tacagctttt agaactggtt acaatagcga 1694881 cggagagtta ggttattggg ataagttaga gccactttat acaatttttg atggtgtatc 1694941 taaaacattc tctggtattt ggactcctgt aaagaatgac ttcaaagagt tttatgattt 1695001 atacctttct gatgtagaga aatataatgg ttcggggaaa ttgtttccca aaacacctat 1695061 acctgaaaat gctttttctc tttctattat tccatggact tcatttactg ggtttaactt 1695121 aaatatcaat aataatagta attaccttct acccattatt acagcaggaa aattcattaa 1695181 taaaggtaat tcaatatatt taccgctatc tttacaggta catcattctg tttgtgatgg 1695241 ttatcatgca ggattgttta tgaactctat tcaggaattg tcagataggc ctaatgactg 1695301 gcttttataa tatgagataa tgccgactgt actttttaca gtcggttttc taatgtcact 1695361 aacctgcccc gttagttgaa gaaggttttt atattacagc tccagatcat cgaattcctg 1695421 tctgagttga ttgacttggc aaaagaacga gggctaaaca aaccagataa acaaatacgt 1695481 gcgcaggctc agcaaatgat gaaaacacag cgcgcctatg atttggagtc gtacactgtt 1695541 aagcctctcc ctgatcctga gacggtaaaa tgttattatt tccgcaacaa aagcaggtct 1695601 ttctttggtg atttagacac ttatttcact ttatcaaatg aaaaagaacc gtttgatcaa 1695661 gctgcctatt gggaggaatg ggagcggcaa attcctcatt tccacctggt ggatgtcgat 1695721 tcaagcaacc acttcatgat attaaccgaa ccgaaagcgt caacagccct gttagaattt 1695781 tgcgaaaagc tctattcaaa caggggagta gtgaatgcga atttccttaa ggctttccgg 1695841 aagaaacatg aagcgaggga agaaaaagaa acagatgaat tggtgaagcg ctgagaaaac 1695901 acaaacgccc cctcttttaa aagggggcgt tttgaatgtt attttgaaag tgaaacaggg 1695961 agactttcta atcctcttaa aaagacattt tttctccatt gaatgtcatc aggtgcaacc 1696021 gcaagttcaa tatcaggaaa tctcttcaaa agtgctttaa atgcaatgtg gccttccagc 1696081 ctggcaagag gcgctcctaa gcagaaatga atgccaaaac caaaagaaat atgtctatta 1696141 ggcgaccgat ttatatttaa tatttcgggg ttctcaaaaa aattcgggtc gcgattggca 1696201 gatccgatgc ctataaaaat catgtctcct cttttgatcg aatgcccctt atatgtaaag 1696261 tcttcgatgg cccaccgatt tgccatcata acgacaggtg aggtgtatcg cagcaattct 1696321 tcaaccgctg tagcgatcat ttcaggctgc tgcttgagct tctcacattc cttcttgtgc 1696381 tgcagcaatg cgagggtgcc tgagccgagt aagttaacag ttgtttcaag gccggctaca 1696441 acgagcaaga acagcatcga atagagctct ttttcgctta acttgctgcc gttttcctca 1696501 gcatgcacaa gtttgctgat taaatcgtct tttggcttta ttcttctgtc atggatcagc 1696561 ttagcgatat aatctttaaa ttcacgaagg gcctgatttg tcagctctct attaccttca 1696621 gaggtatcaa ccatcgcatt ggtccagatt tgaaactgtg accgatcttc ttttgggatt 1696681 cccatcaatt cagatataac aataaaaggc aaaggggaag cgaaggattt catgatatcc 1696741 gctttatttt ctttttccat ttcatctaaa agctgttcag caatttgttc aatgctgccg 1696801 cgcagatttt caatggttcg gggagtaaat gcttgatgaa caagtgatct caggcgggta 1696861 tggtcaggtg tgtcttttgc cagcatatga tcggatacaa aatcgatatc ttcactaacg 1696921 ttgagcattt tgatttgttc ttggttcatc acatttttta cgtctcttgt aattcgattg 1696981 tcttttaaaa aggccataca atcatcgtat cgggtaatta accaggccgg atatgtggct 1697041 ccgaaccgtt ttaattcaaa tcggtgaatg ggctcttcct ctctaaatcg tcctaaaact 1697101 gaaaaaggat tgtgatgaaa ctctttacca tgcggatgaa acatcaattt ttccatttgc 1697161 attctcctcg cctaataggg taaatagatg aatcaaattg ctgaattagt ttacaaaaaa 1697221 cagaatgatt tgaaatgtaa tcctgtctct aaaactatat atctatctta ggcgtcattc 1697281 aatagggaga agaacgaaaa aagtgaaaaa acggctcgat ataaagcagc gcctttgaac 1697341 gaaagctcaa aggcgctacg ctgtattatt ttgatgaaag tggctgtcag ctgtgctgga 1697401 tatcaattgt atatactgca cgatctgtta cgaccttcaa tccttcgttt tcttggtgaa 1697461 tatgaagctc acctaataaa ggaatctcat aggcattttg cggaagcggt acgtttccgt 1697521 cctcagtgaa tgttgttcct tcgccttcta aaacaagctc ttctttcgca acataatcat 1697581 caggatgatt cgtactgcgt atagccactt tttgaaggtg gagaacaatc tgatccaagt 1697641 ctgatatctc ttcatcatgg gtcaattcac cttttctaat atcaagcgtc tggccgactt 1697701 ttgattccag ccattgagaa agctgtgtat tcgtgtgtgc catcaatatt cctccttttg 1697761 atctacacga tactattccc aattgctgca tcttttacac gggaaagagc cgccccactc 1697821 tttatgtatg aaacagttcg ctgttgagtg ccttgatata gcgtacggca gaacgctgga 1697881 ccgattcgtc ggcattttct ttgacaactt tagagaaagc attgtaaagc cggttgaatt 1697941 gaagcggttt tactttggct gctatttctt caactttgga ggcgggaagg ggaatgagat 1698001 ttgggtagct gtacataaag ctgacccagt ttcgatccgc cgcaaccgta atgatatctc 1698061 cggtcaatag acagcctttc ccttcattgc ccttgctcca atgcaaaaca gcaccgcctt 1698121 taaaatgtcc gcccagtcgg taaaggtcca gtcccggctt catattgagc gtttcccctg 1698181 accagaagtg aatgtgattg cttggccttg tcacccattc tttatcatcc tcatggatat 1698241 agatcggcgc ctgaaacgct tcagcccact caacctgagt agagtaataa tgtggatgag 1698301 acaaggcgat ggcttgaata ccgcctaatt cgttgatttg gtcaattgtc ttttggtcaa 1698361 gatatgtcat gcaatcccac agcacattga agcccttatg ctgaataaga tgggctgttt 1698421 gtccaatcgc aaactctggt tcagttttga tgctgtaaag atgctcttct tcctttttaa 1698481 ggatgttttg aaggtttcct ttctcacgca tgtcttcaag ggttgtccaa gtttgtccat 1698541 cgggatgaat atactgtctt tcatcctcgc aaatcagaca cgagttgggc ggatctacag 1698601 tctgtgcatg ttgcacaccg catgtattgc agatataata tggcactttc ttcacttcct 1698661 tcatctattt tccattattt taccttatga ttatgaatat tcaaacgaaa aaaccggcag 1698721 ttctgctgag agagaattgc cggcttttga tgatgtttat tggccgggaa cggaattttc 1698781 tgcgttgaca gcgcccgctc cgtagatatt cggatcttca tctttccatt tgtccgtgcc 1698841 gtttttcaaa agctctttta cttcatcagg ggtaagatcc gggttttgct gaagaattaa 1698901 agctgcgatt cctgcgcaaa tcggtgttgc catcgaggtt cctgacattg taaagtactg 1698961 agaccctaca cggcttgact tttggagctt atcaatataa gaattcggag agcgaaggga 1699021 aataatatta acacccggcg ctaaaatatc gggcttttct ttcccgtata ctgtcgggcc 1699081 gcggcttgag aaggaagcga cagtatcatc atcgctgctt gcagtattgt tatcgtcaag 1699141 cgcacctact gtaatcacct tttcgctcac gcccgggctt gcaatggtct gcgaatcagg 1699201 gcctgagttt ccggcagcga cacagacgac aatccctgcg ctccacgctt cctcaaccgc 1699261 tctgactaac ggatcttcct gttcatgatc atatctaagg gcatcgcccc cgagcgacat 1699321 gctcataata tcaatcggtt catcggggtt gtcctcattg tattgaatac accactcaac 1699381 accctctata atatctgcta acgttcctga accctgcttg tttaatacct ttacgccgat 1699441 gagattggct tccggtgcag gtccgcggta ttgaccggaa gaggatgcac cgctgcttgc 1699501 gacatcacct gcacagtgtg tgccatgacc attatcatcg tacggctctg ttttttgatt 1699561 gaccatgtcc gcgaatccga taattcttcc ttctagatca ggatgcgggt agattcctgt 1699621 atcgacaaca gcgacagtaa caccttttcc tgtcagggtt tgcccgtttc tgacgacttc 1699681 cttcgcatgg cttgcttcgg ttgccgtgtc taaaagcgct ttgacttcgc ggtttaaata 1699741 cactttacgg atattgctgc attcagagag aagggaatgt aatgctgaag gagtaacctc 1699801 ggcgctgcag cagttgattt tgttgaagcg gctttttagc ttgctgcgtt tttctttttg 1699861 cagcacctct ccagccattt gaaagccggt ctcgtgacag ccttcctcaa attcgataat 1699921 gactgacatt ttttttctgt tttgcaattt ggtttcgaaa aatttatgca agaagcaagg 1699981 agtccatttg aagggcttgt aaagttgcaa tacggtttcc cgtaacggcc aatctagctt 1700041 gtgagcattt gctctcacca tttgtaccat agagtaccca aacatgtatt ttcctcctat 1700101 tataaggttc tctgtatact ctatgaacag atgataggtt tggtaagttt gtttgtcctc 1700161 tgtaagagac agacaagagt ttgtttttct gaatctttcg cattagatac gatagattca 1700221 gaagctgagg aaatcattgg ggattgaaaa agaacgtttg ttcgtattat aatgtgatca 1700281 tatcaaactg ggaaggggag agcaaccgta tgaatttcta cttgcaccga tctttggaaa 1700341 gccaaatgcc aatcagcatt atatatgaag aaagacggaa cgattagtaa aagaacgatt 1700401 attgtgagac agaaaagcaa aacgaaaatc aaagcatttt gtttttcgaa acaacagatc 1700461 agaacatttt tattggactc tatcctctcc tgtgattttg tgagaacaaa taagcaaaat 1700521 ctctattctg caggccggta acagctgtcc gtctcagcaa ccgggcagcc tgttactaaa 1700581 accctcctta aacctatata catttatttg ccaagtgagg ttgttcctac cttttttgtc 1700641 tttcctctca accttttttc actcttattt gaaatgaacc gctaataacc gtgacaatca 1700701 attgattttt tgaaaccggg aactttttca ctgatgatat tgtgtataca atggtaagat 1700761 aaaacctatt ggctaaacct catataatga accgcgccat tcttatgaaa ggagttaaac 1700821 atgagaagat ttttactaaa tgtcatatta gtcttagcca ttgtcttgtt cttgagatat 1700881 gttcattact cattggaacc agaaccatca aatcagccag atacatattc aaatttcagc 1700941 agcttggcag agaatgagag cccagccgat tacgatattt catataatga gaaaaaagga 1701001 agcaaagtct taattatgtc tccgcatggc ggaagaattg aaggcggagt aagtgagctt 1701061 gtgcgttatt tcaataatga atactctaca tacctatttg aagggttgaa gtcccatgat 1701121 aaccaaacac tgcacattac aagcaccaac tttgatgagc cattggcaaa aaagaaaatc 1701181 aaggagcatc aatatgtggt ggcttttcac ggatataaag gagagaacaa gaataccctt 1701241 gtagggggaa cagaccgaaa gcgggcgaaa atgattgtga gagcccttga gcggagaggg 1701301 ttttccgctg agttagcgtc gtctaaaagc ggtcttgctg gattgaatgc cgaaaacatt 1701361 aataaccaag gggaaacggg gctaagtatc cagctggaaa tcagccgtga gcagagagaa 1701421 gcattttttg atgattttta ttataaaaat agaaaataca caaagaacag tgaattttat 1701481 gcttatgtca gtgcgatcaa aggtgtcctg gaaaaagagt attcgtaaca agcagatcag 1701541 aagacaaaat aagagaagat cagtagactg aaataggata aaaaaggagg caaaacaatg 1701601 gcagatcatc atttttattt aaaagcgaac tggccgggta accgtaatga tgtcggtacg 1701661 atcgaaagcg gaaacctgat cacatcgatt tccattccta aagaaatgga tggcccggga 1701721 gaagggacca acccagatga aatgcttctc ggggcggcag cgacctgtta cattattaca 1701781 cttgcagcga tgatggagag aagcgggctg gaaaaagaag acttacagat ggagtcagaa 1701841 ggcattgtca acgttacaaa aggagtcttt acatacaaaa agatcattca ccgtccctct 1701901 gtcgtgctta aacatgatgc ttcacaagac gacgtcgcat tggcgcacaa actttgtaaa 1701961 aaagcggagt cgtcatgcat gatttcgcgt gcaattcaag gaaatgtcga gctgcagctt 1702021 gaagcctctg tgaaactggg tggagaataa agaaaacaga cggtcactca caggccgtct 1702081 gttttttatc ttcagcgtgg gctttcgatt gatttagcac gaccacgcct gcaatgacaa 1702141 gcgtgagacc gaatacacct tttaaactga tggtttcgcc aaaaagcaaa aacccgacaa 1702201 ttgctgtaag cgcggtacca acgcccgacc atgttgcata cgcgcttgat aagtcaattg 1702261 tttttaaaga aaagcttaga aacgtaaaag cagaaagaaa tccgactatg actccggcaa 1702321 tgggccaggc ttgtgtaaat ccttctgaaa gcttcaacat cgtgctccca aacacttcag 1702381 atacaatggc gagagccaaa taaagcaatc ctctcatctt catcactcct ttacggccaa 1702441 ttaagtaaca cgacccctga tagtaataaa agaatcccga taagcccttt ggcattcaga 1702501 tcttccttga accattttac tccgatcact gtcgtcagca ccgtgcctgc cccgctccaa 1702561 gtcgcatagg agaggctcag gggaatatgg tttaaagtca gggacagcat ataaaaggcg 1702621 agggaatagc caataacgac caaagcactt ggcttccact ttttgaagcc atcagatact 1702681 ttcagcatgg ctgctcctat cgattccgaa catatggcaa tcgtgaggaa tatatatcct 1702741 atcaacatca tgaattctcc tcactatatt tttagattag aaaaaaaact tcagctagaa 1702801 aaatattagt gtatgcctat gtatgagtca agagattcat tttcacacac ttaaaaagac 1702861 ccctttttaa ggggtctttt gcgtttaata ataaaaaggg aacggggcat acggataata 1702921 ggggtatccg ccatacaaat aaggattaaa taaagcgctt cctataagcc cgcctgcaag 1702981 gccgccgata aacggtcctc caaaaaatcc gaatggccgg ccaaacccat aaccaaatcc 1703041 gggtcttcca aacccgtaac cgaacccgaa cggtcttcca aacccaaatg gtctcccgaa 1703101 tccgaacggc cttccaaata ttcttgtatc ttcagggctg aaatgctcta actcgttcat 1703161 gttttctttc ctcctgtaat aaagtgtaga tgatgcagtg tattcaccct gcccggattt 1703221 gattgggcga atcgaggaaa aggaggatgt gaacacattg ggcctgtatc agtctgactg 1703281 gtcaaaagca ccgccccacg cacatgctta tcatgtcaaa acaacgagag aacagggcca 1703341 ttatcatctc atcgaagggt ttactcagcc ggcaaacgga tcaaataccg atcagcatac 1703401 acattactat acagggatca cttcatttga aaacggccat tttcatcggt attacggaat 1703461 ctcaggaccg gcgattccct tagcagatgg cacacattat catgaaatcg aagaaacgac 1703521 gtatctggcc tataacgagc cgattgagat ccagtacgga ggggttgtgt acgatcccgg 1703581 agatgacaga agaaaaacgc atcgtcatac cctgaaagga aagacaaggg aaattgtcgg 1703641 caatgagccg ctcggctggt agaaggatgt ttaccgatgc aaaaaaaggg caaaatggat 1703701 aggtggttgt ccatgttgaa tgctataatg gggggagatt tataaaagag agtgatacat 1703761 attgaataat acgaagcagc ccgttgtcat tttagtcgga ccgacggcag tggggaaaac 1703821 caatttaagt attcagctag ccaaatcctt aaacgcggaa attatcagcg gagattcgat 1703881 gcagatttat aaagggatgg atattggaac agctaaaatt accgaacagg agatggaggg 1703941 agtgccccat catctgattg acattttaga tccccaagac tctttctcta ctgccgatta 1704001 tcaaagctta gtaagaaata aaatcagcga gattgcaaat agaggaaagc ttccgatgat 1704061 tgtcggcggt acagggcttt atatacaatc tgtgctttac gattatacat ttacggaaga 1704121 ggcaaatgat cccgtgtttc gagagagcat gcaaatggct gctgagcggg aaggcgctga 1704181 ctttcttcat gccaaacttg ctgcagcaga tcccgaggca gcagctgcga ttcatccgaa 1704241 taatacaaga agagtcattc gcgcactgga aattttacat acgtccggaa aaacgatgtc 1704301 ccagcatttg aaggaacaaa aacgagaact tctgtacaat gcagtgttaa ttggcctgac 1704361 aatggataga gacacgcttt acgaaagaat taatcagcgg gtcgatttga tgatgcagtc 1704421 aggccttctt ccggaagtga aacgcttata cgacaagaac gtgagagact gtcaatcaat 1704481 acaggcgata ggctataaag agctgtatgc atattttgac ggttttgtga cactttccga 1704541 tgctgtcgaa cagctaaagc agaactcgag gcggtatgcg aaacgccagc tgacgtggtt 1704601 tcgcaacaaa atgcaggtca catggttcga tatgacaccg cctgttgata tggagctgaa 1704661 aaaaaaggaa attttcacac atatagcagg aaaactcgaa ctttaatcga aactgtatga 1704721 tatagagaat caaggaggac gaaacatgaa accgattaat attcaggatc agtttttgaa 1704781 tcaaatccgg aaagaaaata cgtatgtcac tgtttttttg ctgaacggct ttcagttgcg 1704841 gggccaggtg aaaggctttg ataactttac cgtattgttg gaatcggaag gtaagcagca 1704901 gcttatatat aaacatgcga tctcaacgtt tgcgccgcaa aaaaacgtcc agcttgaact 1704961 cgaatagatc aaaaaatgcc atgtcaagac atgaggaaag gctgtcgggg gttcccggcg 1705021 gccattttta acatgaatcc acttttgctc caagcttttt gtgtaagctg accatgccaa 1705081 ggcacggtct ttttttatga gaacaacata cggaagtaaa aatggtatat tatgtataaa 1705141 atgaatttgg gagtgatcga tcttgtttga aagtgaagca gaactgagac gaatcaggat 1705201 tgcacttgta tggatagctg tctttttact gttcggggcg tgcgggaatc aagataccat 1705261 tattgaaaca gacaacggca attcagacta tgaaacgcct cagcccacct cgtttccact 1705321 tgaacataac cattttggcg ttatggagga cggctatatc aaaatttatg agtataatga 1705381 gtcccgcaat gaggtaaagc tgaagaaaga atacgcggat gatgagcttg aataaaattc 1705441 acaagcattc gaatttacaa agcggatgcc agccgctaaa ctaaatacag acacagatca 1705501 aacagagggt gaaaacatga agcataaagt gatcgtgaat cattgggaag aaatttgcga 1705561 agatgattct tgctatgaat acggaacaag tatcattgtg aacggaaaag aattaatcag 1705621 agaagcgtca attatcactg ctttgaaggc ggttttagaa gagatcggcg cggatgttga 1705681 aatagaagaa acagtagaga gcgaaaaatg ctgtgatagc ttaagaaaaa aaaatctaga 1705741 ctactaagca gttttttttc atgttatgat atacatcggc taaaaacgac accccgagta 1705801 ggacgagaga tgattctcgt tctgctctct tttttgggcc ctaatgagtc tgcccgtttg 1705861 cctgatttga tcaaaatatg aatttttcat aaaaacgaat ctatatattg tgtttttgct 1705921 agagggtagt atactatata tagtgttagt gatgagagat tcatattttt tgataggtcg 1705981 tgataaaacg tggtacaaat catatttgat tcgaaaacag ggaatgttca gcggtttgtg 1706041 aataaaacag gctttcagca gatacgcaag gtggacgaaa tggaccacgt ggacactccg 1706101 tttgttttgg tcacctacac gacaaacttc ggccaggtac cggcatcaac acaatcattt 1706161 ctcgaaaaat acgcccatct cttattggga gtcgctgcga gcggcaacaa agtatggggc 1706221 gataactttg caaaaagcgc cgataccatt tcaagacaat atcaggtgcc gatcttgcac 1706281 aaatttgaac tcagcggcac atctaaagac gttgaattgt ttactcagga ggtagaaaga 1706341 gttgtcacaa aatcaagtgc caaaatggat ccagttaaat aacgaaatca tgatccaaaa 1706401 agatgggaaa ttccagtttg ataaggataa agaagctgta catagctatt ttgtagatta 1706461 tatcaatcaa aacacagtct tctttcacaa tttaaaagag aagctggatt atttggttga 1706521 aaaccaatac tacgaagagg aattcttaag cctttattct tttgaagaca ttaaagaagt 1706581 gtttaagaca gcttacgcta agaagtttcg ttttccttcc ttcatgagtg cgtttaaatt 1706641 ctataatgac tatgctttga aaacgaatga caagaaaaaa atcctcgagc gttatgagga 1706701 ccggatctca attgttgcgc tgttcttcgc taacggcgac actgagaaag caaaagaata 1706761 tgtaaacctg atgatcaatc aagaatatca gccgagcaca ccgacatttt tgaatgccgg 1706821 cagaaaacgc cgcggtgaac ttgtgagctg cttcttgctc gaagttaatg attctttaaa 1706881 tgacatttca agagcaatcg atatctccat gcagctttct aagcttggtg gcggggtttc 1706941 tcttaacctg tccaagcttc gcgcgaaagg tgaagccatt aaagatgttg agaatgcgac 1707001 aaaaggcgtt gtaggcgtca tgaagcttct tgataacgcg ttccgttacg ctgaccaaat 1707061 gggacaaaga caaggctccg gcgcggcgta tttaaacatt ttccaccgcg atatcaatga 1707121 ttttcttgat acgaaaaaga tttctgcgga tgaagatgtg cgtgtcaaaa cgctttcgat 1707181 cggtgttgtc attccggata agttcgttga gcttgcacgc gaggacaaag cggcttatgt 1707241 attctacccg cacacgattt ataaagagta cggccagcac atggatgaga tggacatgaa 1707301 cgaaatgtac gacaagtttg tcgacaaccc tcgggtgaaa aaggaaaaaa tcaacccgcg 1707361 gaaactgctt gaaaaattgg cgatgcttcg ttctgaatca ggctatccat acatcatgtt 1707421 ccaagataac gtcaataaag tgcatgcgaa taaccatatt tccaaggtca aattttctaa 1707481 cctttgctct gaagtgctgc aggcatctca agtttcttca tacacagact atgatgaaga 1707541 agatgaaatc ggtctggata tttcctgcaa cctgggttcg cttaacattc tcaatgtcat 1707601 ggagcataaa tcaatcgaaa agacagtcaa gcttgcgaca gactctttaa cacacgtgtc 1707661 tgaaacaaca gacatccgta atgcgcctgc tgtaagacgg gcaaacaaag cgatgaaatc 1707721 aatcggcctc ggtgctatga accttcacgg ctaccttgcg caaaacggca ttgcgtatga 1707781 aagtccggaa gcgcgtgact ttgcaaacac gttctttatg atggtgaatt tctactccat 1707841 ccagcgttct gcggaaatcg caaaagagaa gggcgaaacg tttgatcaat atgaaggatc 1707901 aacctatgcg acaggtgaat acttcgacaa atacgtttca actgatttct caccgaaata 1707961 cgaaaaaatc gctaatctgt ttgaaggtat gcatatcccg acgacagagg actggaaaaa 1708021 gctaaaagca tttgtcgctg aacacggtat gtatcacagc tacagattat gcattgcgcc 1708081 gacaggctct atctcatacg ttcaatcaag cacggcgtct gttatgccga ttatggaacg 1708141 gattgaagaa cgaacatacg gcaactcaaa aacgtactac ccaatgcctg ggcttgcatc 1708201 taataactgg ttcttctata aagaagccta cgatatggac atgttcaagg ttgtggatat 1708261 gatcgccact atccagcagc acattgatca gggaatcagc tttacattgt tcttaaaaga 1708321 cacaatgacg acccgagatt taaaccgaat cgatctgtat gcacatcata gaggaattaa 1708381 aaccatttac tatgcaagaa cgaaagatac tgggcaagac agctgccttt cttgtgttgt 1708441 ttgattaaag gagagtttat agtgacaaaa atttatgacg cagcaaactg gtcaaagcat 1708501 gaagacgatt ttacccaaat gttctataac caaaacgtga aacagttctg gcttccggaa 1708561 gagattgctt taaacggcga tctcctcaca tggaagtacc tcggaaaaaa tgagcaggac 1708621 acttatatga aggtactggc cggacttacg cttcttgaca cagagcaggg gaatacgggg 1708681 atgccgatcg tggctgaaca cgtagatggc caccagcgga aagcggtgct gaactttatg 1708741 gcgatgatgg agaacgctgt ccatgcgaag tcgtactcta atattttcat gacccttgca 1708801 ccgactgaaa cgatcaatga agtatttgaa tgggttaaac aaaataaata tttgcagaaa 1708861 aaagcgcaaa tgattgtcgg gctttacaaa gccattcaaa aagatgatga aatttcactg 1708921 ttcaaagcca tggttgcttc cgtctatctg gaaagcttcc ttttctacag cggtttctat 1708981 tatccgttat atttctacgg acaaggaaaa ctgatgcaaa gcggtgagat cattaacctg 1709041 atccttcgtg acgaagcgat tcacggcgtg tatgtcggtc tccttgctca ggaaatttat 1709101 aataaacaga cagaagagaa aaaagcagag cttcgtgaat ttgcgatcga cctcctgaat 1709161 cagttatatg aaaatgagct tgagtataca gaggacttgt acgatcaagt cgggctctca 1709221 catgatgtaa agaaattcat ccgctataat gcgaataaag cgctgatgaa ccttggattt 1709281 gatccatact tcgaagagga agacattaat ccgatcgttt taaacggatt aaacacaaaa 1709341 acaaaatcgc atgacttctt ctctatgaag gggaatggct ataaaaaagc gacagttgag 1709401 ccgctcaaag atgatgactt ttattttgaa gatgaaaaag agcagatata atatctgctc 1709461 ttttcggctt gaaggttcaa atgaggagga cgcagtaccc atgggaaaaa tggacgaaat 1709521 gattttagtt gccccgcgcg atgatgtgtt taaaaaagaa agcttaacct tccagggcgt 1709581 gtacagtgaa gatagcagag tagcagaaat catggctcag attgaagcgg cctatcgtga 1709641 aatgagaaga ggggacgcag aagaagatcc gcgtttcaag cagccgatac cttatgtcgt 1709701 cattaagcgt gaagatgaag tttttcttta cgagcggctg gctggcggcg gtgaatcacg 1709761 tctgcacaac aagctttctc tcggttttgg cggccatatg aacgccatcg aaggggcagc 1709821 ttcatttgct gaagtcttaa agctgaacac agaccgtgag cttgaggaag aactgcaaat 1709881 aaatgaagaa gataaacagg cgattgtcac actgggattg atcaatgatg atgaaaacag 1709941 tgttggcaaa gtgcatatcg gtattctttc tgcgcttcaa ttaaagcctg gcgcacaagt 1710001 ggaagtgaag gagaaagaac aaattgcggg taaatggatg aaagtttctg aattaaaaca 1710061 ggatgatatc tacaaccgtc tggaaacatg gtcacagttt gttgttgata ttcttgaata 1710121 aaaaaacccg gtttctcgcg atgaggagcc gggttttttt atgagacgct cgtccccgtc 1710181 tcggctatga ttctaggatc acaatagcgt caaagccggc atttttcgct ctggcagcga 1710241 gggtgtctgc attgtctttg gatgaaaatg cgccaatctg cactttgtat aatccgtcct 1710301 ttaaaaggac aatcgagtca aaacctttgg cttcggcatt acttgcgagc gagtcggcat 1710361 tcgctttgac tttaaatgcg ccgatttgaa ccttatataa ccctgagctg gaagtctttt 1710421 taaggttaaa ggcttgctcc agcccgtttg catgtcctct cgctaagctt tgaataaaac 1710481 tgctcgtttt cagcttattt gcatcggaaa cggtatcaat gaagccgttc tcggtcaaga 1710541 gggcaggcat tgccgactcc cttaggacgt ggaagttcgc tgtttttttg ccgcgatcgg 1710601 caaagtcgac agcttgtatc acttcagagt gaattgtcga ttgataagtc gtcgtcgggg 1710661 ctcctacatc tggataaata tagctttcaa aacctgtgcc tcccccggaa ttaacgtgaa 1710721 tggacaaaaa gaaatctgct ccccagttat ttgcggcatt tgtccggtcg tttaagctga 1710781 catattggtc gcttgtccgg ctcagcagca gagaaacgcc ttcatattca ttagttaata 1710841 tcgtacgtaa ggctaaagcg atttgcaggg ttaacgtttt ctcctgaagg ccattacctg 1710901 ttgcgcctgg atcagacccg ccatggccag gatcaataaa aattttaacc atttttcatc 1710961 acctcattac aggatatgaa aaaacacggc ttctgcttgt acgattatca ttcaactgaa 1711021 aaatgaggaa ataacccttt cacatccaga aattatttct cgggaaagcg cacaattcaa 1711081 catgaagcga caacagatac ggtccgacat gaaatctgtg catacgccat atgtttgtat 1711141 gtactatggg ttcggttaac ctgcactgat tcctgctggt tttaagcttt gcgttcatat 1711201 taaatcaagc atttaaaacg taaattgatg aggaaagctc ctttcattaa agacaccgct 1711261 ttataaatcg aaaaaaagaa aaacacttca ggtatcttag ggcgggtaat acgtttcgta 1711321 caaaaatcag cccgttgtat gaaaaagaaa taatgagaaa gaagctcact ataatactct 1711381 gacaaaatga ttaaaaacaa aatctcatgg tttgtccacc ccatgtccgt gaatacaata 1711441 agaaataaag tatttctcgg gaaagcgcag gattccttat tgttcccgaa aaaagcaatt 1711501 gtttcgacac atgataggcg tttgtcacaa tcggcatccg cttgaatatc atatagagag 1711561 aacagagagg tgaagatgtt ggagcgcgct gtgacttata aaaacaacgg acagatcaac 1711621 attattctga acgggcaaaa gcaggtgctg acgaatgctg aggcagaggc ggaatatcag 1711681 gctgcattgc aaaaaaacga agcaaagcac ggcattttga aggaaatcga aaaagagatg 1711741 agcgcattag ttgggatgga ggaaatgaaa cgcaacatca aggaaatata cgcctggatt 1711801 tttgtgaacc aaaaacgcgc ggagcaaggc ttgaaggttg gaaagcaagc gctgcacatg 1711861 atgtttaaag gaaatccggg aacgggaaaa acgacggttg cacggctcat cggcaagctg 1711921 ttctttgaaa tgaatgtcct gtcaaaaggc cacttaatag aagcggagcg ggctgacctg 1711981 gtcggggagt atatcggaca caccgcccaa aagacgagag atttaatcaa aaagtcatta 1712041 ggtggcattt tgtttataga cgaagcctac tcgctggcaa gaggcggcga aaaggacttt 1712101 gggaaagaag cgatcgacac acttgtaaag catatggaag acaaacagca tgagtttatt 1712161 ttgatactcg ccggatattc acgggaaatg gatcattttc tctcgttaaa tcccggactc 1712221 caatcaagat ttcccatctc cattgatttt ccggattact ctgtgaccca gctcatggag 1712281 attgcgaaac gaatgatcga tgaaagggaa taccagctca gtcaagaagc ggaatggaaa 1712341 ttgaaagatt acttaatgac agtgaaaagc acgacaagtc ccattaaatt cagcaatgga 1712401 cgttttgtca gaaatgtgat cgaaaaatcg atcagagcac aagccatgag gcttttaatg 1712461 ggagaccaat acttaaaaag cgacttgatg accatcaaaa gccaagatct ttccattaaa 1712521 gaagaagcat ctggatctgc atagacctct cagtttttga gaggtctgtt ttttgctcgt 1712581 atttccgctt ttcaaagcaa tcgatttgtg gtatacacat gcagggtttg gtatgataat 1712641 actactgccc aatatgcaaa agaaaggaac atccatttga acgaacaaga aacgattcag 1712701 gagaaagcca ttttagtcgg atgtcagctg ccgcatatca cggatgagca ttttgaaaat 1712761 tctatggaag agctagcatc tctgacgaaa acagcagacg gaaaagtact gaccagcgtc 1712821 acacaaaaac ggaacagggc tgacgccgct acatatatag gaaaagggaa ggtagaagag 1712881 ctgaaggcac tcgtggaaga gcttgaagct gatctcctca tctttaatga tgaactgtcg 1712941 ccaagtcagc tgaagtcatt ggcaacagca attgaagtga agatgattga ccgcacgcaa 1713001 ttgatattag atatttttgc aaagcgggcg agaacgagag aaggcaaact tcaaattgag 1713061 ctggctcagc tgcaatatgc actgccgcgt ctgacgggac aagggatcaa cctttcccgg 1713121 caaggcggag gaattggggc aagaggtccc ggggaaacga aactggaaac cgaccgccgc 1713181 catatcagaa atcgcattca tgaaatcaac acacagcttt ccactgtcat tcgccataga 1713241 agccgatacc gtgaaagaag aaagaaaaac ggtgtgcttc aaattgcgct tgtcggctat 1713301 acaaacgcag ggaaatcaac atggttcaac cgcctgacga gtgctgacag ctatgaagaa 1713361 gacctcctgt ttgccacgct ggacccgatg accagaaaaa tggtcctgcc aagcggctac 1713421 agtgttcttc tttcagatac agtaggattt attcaggatc ttccgacgac attgattgct 1713481 gcattccgct caacgcttga ggaagtaaaa gaagcggatt taattctgca tttaattgat 1713541 tcttcaaatg aggattatgc gggacatgaa aaaacagtgc ttcggctgct tgaggagctt 1713601 gaagcagatg atatcccgat gctgacggct tacaataaac gtgatcaaaa actgcctgat 1713661 tttataccga ccgccggaag ggatcacatt atggtcagtg cgaaatttga ggacgacgct 1713721 gcagccttta aagaagcgat tcagcgctat ttgcgccaag aactgttaac gtcttttgaa 1713781 gcacatgtgc cggcaagtga agggaagctc ctttccagaa tcaaatcgga aacgatggta 1713841 gaccgcttct attttaatga agaaaatgaa cagtatgaca tatccggcta tgtccaagaa 1713901 gagcaaagta tcatcggtga attaaagaag tatatgtagg aaggaaatat aaagacatgt 1713961 ttgacacatt aacacacgga gaattattga agaaaacggc aatggaagtg gaagcggaca 1714021 ttgccggcat tcataaacaa atagaagaaa tcagcgagcg aaatgagtgg agagtgcttc 1714081 aaagctatag aaaacacaaa gtaagcgaca ctcatttcac gccgtctact ggatacggct 1714141 atgatgatat cggaagagac acgcttgaaa gcatatatgc ggatgtgttt ggcggagaag 1714201 cggggcttgt aaggccgcaa atcatttcag gcacacatgc catctcaatt gctttgttcg 1714261 gtgtcctcag accgggggac gagctccttt atatcacggg caagccgtat gatacgctag 1714321 aggaaattgt gggcgtcagg ggtggagaaa acgctggttc gttaaaggat tttcaaatcg 1714381 gctataatgc ggttgatctg acgaaagacg gaaagataga ctatgatgca gtcgccgctg 1714441 cgatcaatcc gaagacaaaa gtaatcggca ttcagcgctc aaaaggatat gcgaatcgcc 1714501 cttctttctt aattagtgaa ataaaagaaa tgatccgttt tgtaaaagaa atcaatgaaa 1714561 atctgatcgt ctttgtggac aactgttacg gagaatttgt ggaagagctt gagccttgcc 1714621 atgtcggagc cgacctgatg gcgggatctc tcattaaaaa tcccggcggc ggccttgcga 1714681 aaacaggcgg ctacctcgtc ggaaaagcga aatggattga agcttgctca taccgtatga 1714741 cgtcacccgg catcggcaga gaagcggggg catctcttta ctcgctccaa gaaatgtacc 1714801 aaggcttctt tttggcgcct cacgttgtgt ctcaaagttt aaagggagcg gtgtttacag 1714861 cgagattcct tgaaaaactc ggcttcactt caaacccgaa atgggatgcg aaaagaacgg 1714921 atttaataca atccgttgag ttttctgaca gagaaaagat gattgctttt tgccaggcta 1714981 ttcaatttgc atcgccaatc aatgctcatg tgacgcctta tccagcctac atgcctggat 1715041 acgaggatga tgtcattatg gcagcaggga cgtttattca aggagcaagc atcgaattat 1715101 cagctgatgg ccctatccgc ccgccgtatg tagcgtatgt tcagggagga ttaacctatt 1715161 cgcatgtgaa gaatgccata tgcagtgcag tggattcatt gatgcaaaag caattaattt 1715221 aaatttttta aaaatttctc tggatttgat gttaagaatc cttacatcgt attgacacat 1715281 aatataacat cacctataat gaaactaagt taagaaaagg aggaaattga gatgagtgat 1715341 aatattcgcc gctcaatgcc tttatttcca ataggaattg tcatgcagtt aactgagtta 1715401 tcagcaagac aaattcgata ttatgaggaa aatggactga tatttccagc cagaagtgaa 1715461 ggaaatagac gattattttc atttcatgat gtagataaac tgttagaaat caagcacctg 1715521 atagaacaag gtgtaaacat ggcaggaatt aaacagattc tggcgaaagc cgaagccgag 1715581 ccagaacaaa aacaaaacga gaagacgaaa aaaccaatga aacatgatct gtccgatgac 1715641 gaactgagac agctcctgaa aaacgagctc atgcaagccg gccgttttca aagagggaat 1715701 acattccgtc aaggcgacat gtcccgcttc tttcattaat ccgttagcaa ctgttttgct 1715761 atatacattt accttttaag aggaggaatt ttaccaaatg gcaaagtaca ctagagaaga 1715821 tatcgaaaaa ttagtaaaag aagaaaacgt gaagtatatc cgccttcaat ttactgacat 1715881 tcttggaaca atcaagaatg ttgagattcc tgtaagccag cttggaaaag cgcttgataa 1715941 taaagtcatg tttgacggtt cttctattga gggattcgtt cgtatcgaag agtcagacat 1716001 gtacctgtat ccagatctaa atacatttgt tatcttccca tggacagctg aaaaaggtaa 1716061 agtagcacgt ttcatctgtg atatttacaa tccggatggc acaccttttg aaggtgaccc 1716121 gcgaaacaac ttaaaacgga ttctgaaaga aatggaagac ctcggcttca gtgattttaa 1716181 ccttgggcct gagcctgaat tcttcttatt caaattggac gaaaaaggcg agccgacgct 1716241 tgaactaaac gacaaaggcg gatatttcga cttagctcca actgatttag gagaaaactg 1716301 ccgccgcgat atcgtacttg agcttgaaga gatgggcttt gaaatcgaag cgtctcacca 1716361 cgaagtagca cctggtcagc acgaaatcga ctttaaatat gctggagcag tccgctcttg 1716421 tgatgacatc caaacattta aactagttgt caaaacaatt gcccgtaaac acggcctgca 1716481 tgcgacattt atgccaaaac cattgttcgg tgtaaacggt tcaggtatgc actgcaatct 1716541 atcactcttc aaaaatggtg ttaacgcatt ctttgacgaa aacgcagatc ttcagttaag 1716601 tgaaacagcg aagcacttca ttgcaggtat cgtgaagcac gcaacaagct ttacagcagt 1716661 aacaaacccg acagtaaact cttacaaacg tcttgttcct ggctatgaag caccttgtta 1716721 tgtagcatgg agcgcgcaaa acagaagccc gcttatccgt atcccggctt ctcgcggcat 1716781 cagcacacgt gttgaagtac gcagtgtaga cccagctgca aacccatacc ttgcacttag 1716841 cgtattgctt gctgcaggat tagacggaat caaaaacaaa ctggaagcgc cggctccaat 1716901 cgaccgcaac atctatgtga tgagcaaaga agagcgcatg gaaaacggaa tcgttgacct 1716961 tccagcaaca cttgcggaag cactagaaga attcaaatca aacgaagtca tggtcaaagc 1717021 gctgggcgag cacctattcg aacacttcat cgaagcaaaa gaaatcgaat gggatatgtt 1717081 ccgcacgcaa gtacatcctt gggaacgcga acagtatatg tctcagtatt aatatctcaa 1717141 tcccttggca ctaaaagtgt caggggattt tttatgttaa taggtaataa attatggagc 1717201 ggcactgcta aaaagcaggg tcacttttag tctatgtcac taataattct atgtactaaa 1717261 tttttaatta gggaaataat tccacgctta aggaagcaat acgcataaat aattcgacaa 1717321 attctgtgat aattccattg ttcaatactt ctaccagcaa taataagatg agtaaggtag 1717381 atgtttatca ttgacatcat aaccaaatga atccataatt acgttgaaat ctaaatcaat 1717441 tttcaaaaag gagatttcta tgaaaaaatt gactatcttc tccgggggat taggagcggt 1717501 tttttctgta ctggctcaac tgtttgcggt tatagatgac tcttacactt tggggaattt 1717561 atggttttta ggtgctttgg cgggaattat aaccatgctt gcttcaatcc agacaaataa 1717621 taaaccagtc ttcagcatat tattaattgc tagttcagta ataggtctac ttggaactgg 1717681 tcttgtatac atcataccaa cactgttcaa tataataata atttataaat tttcaaaagt 1717741 aagccaataa gccaatggga aaattaaggt tcttttttta tttaacatcc ctttgacaag 1717801 gtcggtgata aatcgcagaa tgtttatgct tgcaactaat ccaccagcgg gggcatcggt 1717861 gggcatgatt atctaacgcc atgtttctag gataccggaa ttgaaacatt tgctgaggca 1717921 tttcgtgaag ctgatcacca aatgaccatt tccatagagg cacgtctaaa gaagctatca 1717981 taggaggaca atactgtgtg gaaagcttta agtcaattac tcaagaaaca gaaaaatcaa 1718041 agtccaagcg atgaagatta tatacagatt ccagaattag aagtaaaagt tttggggatg 1718101 cttcacagta tcaatataga cctggttaat gtaatagccc aagcagaaaa gtctaaggag 1718161 tttataggac aaatcgaagg catctggcat tctatagcaa atcaatttta ttcactcgcc 1718221 caagggtttg agaatgagga tatcaataag ctttctgcgg atcttgatca tgctgccgcc 1718281 acttgggaag ctgttgctaa taaagcaaaa gagtttgtaa caaattcata ccaagggtaa 1718341 aagaaaaata agggcctgaa agggctcttt tgcttatagt catatttccc gtaagtatta 1718401 ctttttggat ttaataaatt ttaaagcgtg tttgtttcac tgaattcata gtcaaaaggg 1718461 gaatgttttt atgcttggaa tcaacgttga aaaatcaaat gaaaacttaa ttatcaattg 1718521 gcagctatcc aaaattgaaa ttccaatcaa agaaatcaat gatgtatttc ttgatccaaa 1718581 ctatggggga gaggagaaaa gcgcagtaag gattgggttt ccttatggct caacagatag 1718641 ggtagtaatt aaaacagcac gtaacactta cattttgttc accactaatc ctgctttaat 1718701 tatgagtaaa attgtttctt aataaacagt ttatgtccct tttaaattta tctattaatg 1718761 ttctgtgtgg taaaatttag tgagatgatt taaggaggag gagcatttat ggaagaaata 1718821 aaagttagtt cacatgacac tagatggtat taagaaagca gtttctaaat atggtacatt 1718881 ccctatgttt catcatggag gatatgtcat ggaagatgct acttttcatt tcaaagatcc 1718941 tgctagtcct caagaaatta gcgatataga acagaagcta ggtgttactt tccctaatga 1719001 ctataaagag tttttgttac agcacaatgg gatggaaatg tttgatggga ttgaaatact 1719061 tagcttagag ggaatcattg aatataatga ggttcaagat ttcccagagg gatacgtttt 1719121 aattggatat cattttgatg gaagatatgt catagacaca aacaaatcaa aaaatggatt 1719181 aggctatatg ctatatctag actcaattga tgatattgaa gatgcgatta acttagattc 1719241 taatttcgag atatggtttg atatgctagt gtctttaaat ggaacgaaat attgggaagt 1719301 aaatccgaat ctccaagagt attataaact ggtttcagaa taacacttcg gcaaaagaaa 1719361 aaattatgac taatttcaac aaccaaagaa actgcaattt gagggaagta taatgacaat 1719421 ttacgagcaa attaaggatg ctttgaaaaa taagatcaat gagttggttt cacctcaaga 1719481 agtaaagaaa acccttcaag aaaaatacgg aactaatccg gatagcatta ttttatcaga 1719541 ttattgttat aaccggtata ataaggggat ttcttttaat aagcacctct ttgaatatat 1719601 gaatagaagt tcttacaaat acttaggtga aaactctctt tatacaggac ttattttcag 1719661 aaaatcaaaa ggggaagata aggaagttat cgtaggcgaa tgggtaaacg gtgttaaatc 1719721 actccgagaa gcttctgtta ctaataacca aataaatgat caagccgaaa tcattagtaa 1719781 agaacaactt gtaaaccttt ataatgaata taaccaaatc ctgagatatg aaatgaatgt 1719841 attgaactgt aagcctacag aattgaggca tttaattggc agaatcggtg aattcatttg 1719901 tgcaatccaa accaacggca ctctggcacg tcaaactaat cagcatggat ttgatgttgt 1719961 gagtgatggc agacggatta gtgtaaaaac aacagctcaa tcaagtggtt ttatttcgat 1720021 aaataaaaat acattttatg attttgatga tttttttgta gttcaatacg taaatgatga 1720081 ttttaaagtt attttcttcg gctcaaagga agaagtgcaa aaaataagca gaatttatgg 1720141 aagccaatac gaagttgaaa tttcacttct taaaaagctt aataaggaat accaattaaa 1720201 ttaaacaatc ttgttggtaa caaacatcct cttacttatt gtaagaggat gtttgtttaa 1720261 ttcttacata ttttatcttt gcaatctggc ttacgagttg catccacagt aaatgatctt 1720321 acttcgtctt tagttttgtc ataaattccc catattaccc ctcagagaag gataggggga 1720381 ttattttgga gaatcatatt ccattgcttg ttcacagtca gtaatccttg agttgttcta 1720441 gcaagaggca atattgttga ataagaatag ttttaaagag gttattgttg tcttcatatt 1720501 gaaataaaga ttaagtatat tagaggggag ttgctttaat gcacataaca acaaaaaggt 1720561 tattgatacg tgaatttgaa ttcaaagatt ggcaagcagt atatgagtat acatctgata 1720621 gtaatgtaat gaagtatata cctgaagggg tttttactga agaagatgca aaggcatttg 1720681 taaataaaaa caaaggtgat aacgctgaaa aattccctgt catactaaga gatgaagact 1720741 gtcttatagg ccatattgtt ttttataagt attttggtga acatacatat gaaattgggt 1720801 gggtgtttaa tcccaattat caaaataaag ggtatgcttc tgaggcagcc caagctatct 1720861 tggaatatgg atttaaagaa atgaacttac ataggattat agctacgtgt caacctgaga 1720921 atattccctc ataccgagtt atgaagaaga ttggaatgag aagagaaggc ttttttaaaa 1720981 aatgtattcc aaaaggcaat gaatggtggg atgaatatta ttacgctatt ttagaggaag 1721041 agtggaattg aactttattg agtgcggcaa tacaaacaaa ttatcaccct ctacttagaa 1721101 catattagtt aaatgaaggt gatatataaa gtgatatgac agtgattaaa tgggattcaa 1721161 tgagctccgg tgaattgttt ttaggtgagt tcactaagga tgatacctga tacgcagcca 1721221 taccattcga gcgttaatca ttttataact gatcttttca cttttgccca cgggggaata 1721281 agaccctatt taagtttgcc agacgattgt ttgatccgtt gttgatgatt gtcaggattt 1721341 tttgtgaagg aatatcttta tatagtggtt gattattccc ttctggtaaa aattgatcta 1721401 tgttgaattg cttaacatgt cattgaactc agagaataaa gtgaacctgc cacagatgtt 1721461 cattatcttt tagggggttc caaaaagacc gtattcctat cgatcgctca gagtgaaaat 1721521 ggtatactaa agttacaatc acaggaagga attacaattt ttttagatct acataaaatc 1721581 atctgattaa ccgaaagtga gaatgtgtga atgaatttaa tagggtatat tgaggaaagg 1721641 tttcaaaacc tcgaattaat tcctagcatc tataatcaat ggggcacagg aatccatttt 1721701 tgtcttgggg aaaatatcta tcaactcaaa gcaaatgaag aattgaattt aaagatgttt 1721761 cggattgtat atgaacaaac ctcaatcatt tttaatgaat tatttgaaca aaatgatgac 1721821 atattccttg tgacgaatat gtataagcac aaaaagaaag agaaatgtat aagaaaatta 1721881 aaggtgtatc aaccgtttct aaaatgtaaa aatcatttga atcaaattat ggtgaagaca 1721941 tatccctatc ctttcgaaat caataaagct gaagaatacg agatgcaaca attttccctg 1722001 ttatgcaaac ctcgagactt acgtgtaact gaattactta aagcagccag taatgaggat 1722061 tttccacaaa aaccgaaatt cggaggttac tctattgatt accctgatgt tttctttgtg 1722121 aacattacaa aagacattat tttctttatc tatgatgacc gcggatgcga agtcatagct 1722181 catgatttca aacgaatacg tccactttat gaaaaatatc acgactgggt agaagagtat 1722241 aagtgcatgt aatacttttt ttaaaaacga tttatcagga aaggcagaat tagattatga 1722301 gggccttaca tacaagatgt aaacggttat tgaaactaag atggtattat gtgatgatga 1722361 gagatctgca tttttattag tacttgatga aagattagtg gattttgatt ctcaaggtgg 1722421 aaaccatatt agtgtttatt tagttactca ctttgagtta tctgatcaat cgtataaaga 1722481 tgtattaagc tttaatgatg atcttttggg tatggagcat aactgttcgt atgcaatgga 1722541 tattctaagc gttaaagagg aacttgattt cgatttccca tttaatatgc ttgcaataaa 1722601 aagctatgta caagaattaa taaaaatgtt agggattgat atcactctgc ctgaaatgaa 1722661 agaaagagat tttgacaaac tttctcaaaa ctaaataaaa ctactatttt taaagagaac 1722721 ggagacttgc tttcaatatg aatgttaaaa aagctgcagc tgttttttca atcactattc 1722781 caattatctc agccatctta attattaatt tttttacagg atttatgtca attccatggc 1722841 aaggaatgcc ggtgtttttt ccattattac tttctcctat aggaatcatt ttagcgttcg 1722901 tttcaataaa gacaaataaa cggtgtgctg tatatgggat tgtcttaaat gcaattatgt 1722961 ttccatttcc ttttttctgg tttatcggag gggctttgtt atttggagtt taaaatccat 1723021 taggcattac gcttatacat tggtattttc gagcttgtca aaagaaggaa taaaaaaact 1723081 tcagaattgc ttggctttac tttatgttga aaggggtcga gtaaggtgga taggaaaaag 1723141 gatgaaatac aaagaaaata tagggaacaa atgagggaga agaaagaacg agaaaaagaa 1723201 gatggcagtt cacatacttt tgaaattgtt gttgtgctag ccattatcat tttgatgttt 1723261 ttctttaatt cagttttcaa ggctttttag atattgtaca gatgactttc aggatgtttg 1723321 aaaaaataac cctttgagat atataccgca tgaaagtatt gaaggactta tgaaaattca 1723381 agagccagtt gaatcttaat aattaatcac caaataatgg ggatgtaaaa tgaagttgta 1723441 taatgaattt atcaatatag ctaaaacgtt taataaagag ttagacataa ttccattatt 1723501 atatggatct ttaggtcttg aaaaggtaac tgggttagac ttttccccag aagatattga 1723561 tctccttatt cctttaattt ttttagagga aaagtgggaa aaactaaaaa aagtgatgga 1723621 actgcatgga tacaaaatgg ttgatttaca tgagcatgaa tttaagaaaa ctaatacaaa 1723681 aataggcatt tcttacattg aggatttaaa accatttgca gatgtagact ataataacct 1723741 agagattttt gaagatggcg gagcgaaata tcatttgcta acgattgatg attacctcaa 1723801 gatttataaa aagtctttat tagatggtta tagaagaagg aagaagaatc ataaagacca 1723861 aagtaaaatt aacatattga ataaattaat acggaattaa tttctgtatt cccttttgtt 1723921 tccagtctca attaaaattt ttaagattaa aataagtttg aaggaaaaat catagtgttt 1723981 aacacagcca ttaatcctca gacagtcaaa tagccatttc tactccggtt gaaagcttct 1724041 ctatttttgc ttcttattta tctttcctgt attgatatat gtatgtaggg ttggacttat 1724101 aacataaact attctggcca ttccgttctt tcaattcatg accgggcttg ccatcagcat 1724161 aaatctaggc taacagtctc catacatcct gtgatcacct ttatcaaact cttaaatgca 1724221 acttaccact aaccaattct ttatttcgca tagatcatct ttgtcatgtg tttacacaag 1724281 aatctgtttt ggactgagac actgaatata acaaaacagt caaaaatcaa tatttaattc 1724341 attctgttta aactttctga aaaagatgtt gaaaaagtcg aaaggatttt ataatattaa 1724401 gtcaagttag tttgtttgat caacaaacta atgaaatgaa ctttcattat ccacaagata 1724461 agatcttact aatatggatg gaagggggat aagagggtcg atttaatgga gctaaacaat 1724521 ataagaaacg aaagaatgag gcttttatcc ttttccaggt atataaggta tgacgaaaaa 1724581 agatgaattt tttgcttgct gatcaccata tttttttgca ctgttttgaa agcgctttta 1724641 taaaagttta ctgaccgtaa attcgagaaa ttgttatacc gtttcacact gttccatatt 1724701 aaaggatcga aaaggggaga aatcatgctc agtgaaaatg taaagaagat tagcatggtt 1724761 gaaaaagttg gatatgcgtc tggagatttt gcttgtaatt taatttatgc aacagtgtct 1724821 acgtatcttt tgttcttcta tacagatgtt tttggtttat cggcagcagc agccggtact 1724881 atgtttttag tggttagaat aatcgacgct ctcgctgatc cttttatcgg aacaatagtt 1724941 gacagaacga acagcagatt tggacgcttt agaccgtatc ttttattcgg agcttttcca 1725001 tttgtcatac tggcaatact ctgttttaca acaccagact tttcggatat ggggaaatta 1725061 atatatgcct atataaccta tgttggcttg tcgcttacat acacaacgat aaacgttcca 1725121 tatggcgcgt taacttctgc aatgactaga aataatcaag aagttgttag tataacttct 1725181 gttcgcatgt tatttgcgaa tcttggggga cttgtcgttg cattttttgt tcccttactg 1725241 gctgcttatt taagcgatac ttccggcaac gagtctcttg gctggcaact aaccatgggt 1725301 attttgggaa tgataggcgg gtgcctttta atcttttgtt ttaaaagcac aaaagagcgg 1725361 gtcactcttc aaaaatccga agagaaaatt aaatttacgg atatatttga gcagtttcgt 1725421 gttaatcgtc cacttgttgt attaagtatt ttctttatta ttatttttgg agtgaattcc 1725481 atcagtaatt cggttggcat ttactacgta acgtataact tagaaagaga ggatttggtg 1725541 aagtggtacg gtttgatagg aagtttaccc gctttggtca ttttaccgtt tattccaagg 1725601 cttcatcaat ttttggggaa aaagaaatta ctaaactatg cattattact gaatattata 1725661 ggcctcttag ctttactgtt tgttccgcca agtaatgttt acctcatact tgtctgtcga 1725721 ttaatcgctg ctgctggaag tctcactgcc gggggatata tgtgggcgct tattcctgaa 1725781 acaattgaat atggagagta caggactggg aaaagaatgg gtgggctcat ttacgctata 1725841 atcggatttt tctttaagtt tggtatggcc ttaggaggag ttgttccggg tctggttctt 1725901 gataagtttg gatatgtagc aaatcaggca caaaccccgg cggccttaat ggggatttta 1725961 attacaacaa ccattattcc cgtgttcttg cttgttctag ctttaattga tattaatttc 1726021 tataacttag atgagaaaaa atataaaaac atggttcgag aattagagaa tagagacaaa 1726081 gtttatttgg atcatattga tgatttcaag gcttaaaaaa gaaaataaac tgaggaggag 1726141 tcccaaatga agattaccaa tcccgtactt aaaggattca atcccgatcc aagtatttgt 1726201 agagcaggag aggattatta tatcgctgta tctacatttg agtggtttcc gggagtccag 1726261 atacaccact caaaagattt agtaaattgg cacttagttg cacatccatt acagagagtt 1726321 tcacaattag acatgaaagg aaacccaaat tcaggtggag tttgggcacc atgtttaagc 1726381 tatagtgatg ggaagttttg gctgatctat acggatgtta aggtagtaga tggcgcatgg 1726441 aaagattgtc acaattattt agttacttgt gaaacgatta atggtgattg gagtgagccg 1726501 attaaattaa atagctcggg gtttgatgct tctttgttcc atgatacgga tggaaaaaag 1726561 tatttattaa atatgttatg ggatcaccgt attgatcggc actcatttgg aggaattgtt 1726621 atacaggaat attctgataa agagcaaaaa ttaatcggta aaccaaaagt tatatttgaa 1726681 ggaactgata gaaaactgac agaagctccg catctttatc atatcgggaa ctattattat 1726741 ttattaactg cagaaggagg aacacggtac gaacatgctg ctacaattgc tcgttctgca 1726801 aatattgagg ggccatatga agttcatccc gataatccaa ttttaacgtc atggcatgac 1726861 ccaggaaatc cattgcaaaa atgtggtcat gcatccattg ttcaaacaca tacagatgag 1726921 tggtatttag ctcatttaac gggacgtcct attcatcctg acgatgattc aatttttcag 1726981 cagagaggat actgtccttt gggcagagaa acagctattc aaaaacttta ctggaaagat 1727041 gaatggccct atgtagtagg tggaaaagaa ggaagcttgg aggtagatgc accttctata 1727101 cccgaaacaa tatttgaagc aacgtacccg gaagttgatg aatttgagga ttcaacatta 1727161 aatataaatt ttcaaacttt aaggattcca ttcacgaatg aattaggttc attgactcaa 1727221 gcgccaaatc atttacgatt attcggtcat gaatcattga cctcgacatt tactcaggca 1727281 tttgtagcca gacgctggca aagtctccat tttgaagccg aaactgctgt tgagttttat 1727341 ccggaaaatt ttcaacaagc cgctgggttg gtgaattact acaatacaga gaactggacg 1727401 gctcttcaag tcacgcatga tgaagaactt gggcgcattc ttgaattaac aatatgtgac 1727461 aacttttctt tttcacagcc attaaataat aaaattgtta ttcctcgtga agtaaagtat 1727521 gtatatttaa gagtaaatat tgaaaaggac aaatattatt atttctattc ttttaacaaa 1727581 gaagattggc acaaaattga cattgcactg gaatcgaaaa aattatcaga tgattatatc 1727641 cgtgggggag gattcttcac aggggccttt gtagggatgc aatgccaaga taccagtggt 1727701 aatcatattc cggccgactt tagatatttt cgttataaag aaaaataatt tgcacatgaa 1727761 aaaggagatt tctattttag aactcctttt tcatatgaga aggtgccatg tcactattgc 1727821 ttcagaaata ctcctagaat aaaaaaactc atctttaaag atgagctgtc cattccataa 1727881 aaaattacat tgtaatcatg tccagaaaat gatcaatcac aatggaggac attcctaatg 1727941 ccggtgcatt ctgtcctaag gaagatggca ataattcata gctattgcct aattgggaat 1728001 aaacccttga tgatacttca cttctcattg aatttaaaac cataggatgc gattcaatta 1728061 tgctatttct taaaattacg gcttgtgggt tgaaagtatt tagaatattg gtaaggccta 1728121 ttcctaaata gaatccaaaa ttttgtaatg catttaaggt tccgatatca ttcagatggg 1728181 cgaggtttat gatatcttga taggacagtt ttttctcttt ggtctgaaga gattttaata 1728241 aagccttctc tgaagcatac aattcccagc atcctcggtt tccgcaactg catttaggac 1728301 cattaaagtc tattgtcata tgtcccattt ctccagagaa gccgcttact cctctatata 1728361 aatgattgtt gataataaca ccgatcccta ttcctgtgct gatacttacg taaataatgt 1728421 tatcgtgatt ttttgcagct ccaaatactt tttctccata tgcgccagca tttgcctcat 1728481 tttcaataaa aacaggcaca ttgtacttct cttgtatcga agattttaag tcaatatctc 1728541 tccagttgga gttcggagtg aaaacaattt tttgatcttt atcaatgagt ccaggcacgc 1728601 aaatacctat accaataagc ccgtacggag attggggcat ttgcgtaata aagtgatgaa 1728661 tcatatcaat caaaatgtct ttcgttattt ctggagaatt ggattccaaa tggcggtatt 1728721 gatcaagaac gattgttcct tcaaggtctg ttaaaatgcc attaatataa tccacaccaa 1728781 catctattcc aacggagtat cctgcctttt tattaaaaac aagcatgaca ggtcttcttc 1728841 cgccacttga ttgtccttga cctatttcaa ataccatact ttctttcatt aacgtgttta 1728901 cctgtgatga gacagttgat ttatttaatc cagtcatttc agataatttt gctcttgaaa 1728961 taggtgaatt tttaaggatt tcttttaata ataacttttg atttactttt ttgacaaagg 1729021 tttgatcagc gatatccact tcatccactc catttgttta atctttaaat taagtatcaa 1729081 catagtacat agcgaatctt ccctttatta tatctaatgt gttcataaaa aactaaaaaa 1729141 aatattgaaa atactgacga ggttatataa gatgaaaata agttagtttg tttaaacaac 1729201 aaactaatag gtgatgtact tactatatga aataaaatgc atctgtattt gaatgaattt 1729261 atttttaagg gggaaatcac atggctcaat ctcattccag ttcaatcaac tattttggaa 1729321 gcgcaaacaa agtggtttac gaagggaaag attcgactaa tcctttagca tttaaatatt 1729381 ataatcctca agaagtaatc ggcggaaaaa cgctgaaaga gcatttgcga ttttctattg 1729441 cctattggca tacatttact gctgatggta cagacgtttt tggagcagct acgatgcaaa 1729501 gaccatggga tcactataaa ggcatggatc tagcgaagat gagagtagaa gcagcatttg 1729561 agatgtttga aaaactagat gcaccattct ttgcttttca tgaccgggat attgcaccag 1729621 aaggcagtac gctaaaagag acaaaccaaa atttagatat gatcatgggc atgattaaag 1729681 attacatgag aaatagcggc gttaagctat tatggaatac agcaaacatg tttacgaatc 1729741 cccgtttcgt ccatggtgcc gcgacttctt gcaatgcaga tgtgtttgcg tatgctgcag 1729801 cacaagtgaa aaaagggtta gaaacagcaa aagagcttgg cgctgagaac tatgtatttt 1729861 ggggcggccg tgaaggatat gaaacattgt taaataccga tttaaaattt gagcttgata 1729921 atttggctag atttatgcat atggcagtgg attatgcgaa ggaaatcggg tacacagggc 1729981 agtttttgat tgagccaaaa ccaaaagagc cgaccaccca tcaatacgat acagatgcag 1730041 caacaaccat tgcctttttg aagcaatatg gcttagacaa tcattttaaa ttaaatcttg 1730101 aagccaatca tgccacatta gccgggcata cattcgaaca tgaattacgc atggcaagag 1730161 tacatggtct gcttggctct gttgacgcaa accagggtca tcctctttta ggctgggaca 1730221 cggatgaatt tccgacggat ttatattcta cgacattagc aatgtacgaa atcctgcaaa 1730281 atggcggcct tggaagcggc ggattaaact ttgacgcgaa ggtcagaaga tcttctttcg 1730341 agcctgatga tctaatatat gcccatattg cagggatgga tgcatttgca agaggattga 1730401 aagttgccca caaattaatc gaagatcgtg tgtttgaaga tgtgattcaa catcgttacc 1730461 gcagctttac tgaagggatt ggtcttgaaa ttatagaagg aagagctaat ttccacacac 1730521 ttgagcaata tgcgctaaat cataaatcaa ttaaaaacga atctggaaga caggagaaat 1730581 taaaagcgat attgaaccaa tacattttag aagtataaca ggataagctc cagatcctgc 1730641 tatcaatacc aagtcactga attacccgtc atgattcctt tcctattgct tgttgttatg 1730701 acgggtaact tctataatta ggatttattt agagtgaatg gttttttaaa agggcaagga 1730761 gtgaaaaaat gaagtatgtc attggaatag atcttggaac gagtgctgtt aaaaccattt 1730821 tagttaacca aaacggcaag gtttgtgcag aaacgtccaa aaggtatccg ctcatccaag 1730881 agaaggcggg atatagtgag caaaatcctg aagactgggt tcagcaaaca attgaagcat 1730941 tggctgaatt ggtttctata tccaatgttc aagccaagga tattgacggg ataagctatt 1731001 cgggacaaat gcatggatta gtactgcttg accaagatcg tcaggtgtta cgtaatgcaa 1731061 ttctttggaa tgataccaga acaacgcctc aatgtataag gatgaccgag aaatttggcg 1731121 atcatcttct tgacatcaca aaaaaccgtg ttttagaagg gtttacatta cctaaaatgt 1731181 tatgggtaaa ggaacatgaa cctgaacttt ttaaaaaaac tgctgtgttt ttgcttccga 1731241 aagactacgt gcgattccgt atgaccggtg tcattcacac cgaatactcc gatgcagcag 1731301 gaactttact tttacatatt actcgcaagg agtggagcaa tgatatttgc aatcaaattg 1731361 gtatttctgc agatatttgt cctccgcttg ttgaatctca tgattgtgta ggatcgctgc 1731421 ttccgcacgt tgccgcgaag accgggctat tagaaaaaac aaaagtgtac gctgggggag 1731481 cagataatgc ttgcggcgct attggagcag gtatcctttc ttccggaaaa acattatgca 1731541 gtattgggac gtcaggggtc atactttcct acgaagaaga aaaagaaaga gactttaaag 1731601 ggaaagtcca cttttttaat catggaaaaa aggattcttt ttatacgatg ggcgtcacgc 1731661 tcgctgcagg atacagcttg gactggttta aaagaacgtt tgcaccaaac gaatcgtttg 1731721 agcaattatt gcagggggtg gaagctattc cgataggagc caatggactg ctatacactc 1731781 cttatttggt tggtgaaaga acgccgcatg ctgattcttc tattcgggga agcttgatcg 1731841 gaatggatgg agcccataat agaaagcatt ttttgagggc aataatggaa ggtatcacat 1731901 tctctttaca tgaatcaatt gagctattcc gcgaagcggg aaaatcagtt catactgttg 1731961 tttctattgg tgggggagct aaaaatgata cgtggctgca aatgcaagct gatattttca 1732021 atacgagggt aattaagtta gaaaatgaac aagggccagc tatgggggct gcaatgctgg 1732081 ctgcctttgg aagcggttgg tttgaatcac ttgaagaatg tgcagagcag ttcattcgtg 1732141 aggctgctgc attttatcca aaggcgcaaa atgttcaaaa atataaaaca ctatttgatt 1732201 tgtataagaa catttacact cacacaaagg atctcaatac agctttgaag agctttcgaa 1732261 aaaactaatg atgttattgt ctggagatca accgaagaac aattaatgat caatcatcat 1732321 caaaggcctt tgataacatg gctgccttct tttgaaaaga tggtgagaat aaggtatcgc 1732381 aacctttaaa cagtattgga gtatccagca gacaaaacga acgagtggaa ccgtattttg 1732441 tcagcgaaca cttcaagaag tggggaagct taggaatgcc aatgggtaag atgtatgaaa 1732501 ccgcgctaac gacggtagag ggatctcttg atttatgaag aaataggaag gatgttaaca 1732561 cacaaataac ccctcacatt gacgtgaagg ggtgtttttt attgttacta tacagcggaa 1732621 attttacagg ctagttgcat gattttagct tgttaagcag aatggaacta gactctccat 1732681 catctctttc tcattctttg gaaactgcat tctgctaggt ttgctgcttt ttttaacaaa 1732741 cagtgttttt ctatttcaca cagccattaa atcctctgtt cgtcacataa ccgctcttac 1732801 tccaaattga cagtttatct gattttgctt cttgctcatc tagtctgaat tggtctatgt 1732861 attttgtgtt aggctcatat acatatgcta ctctggccaa tccctctttc aataatgtct 1732921 cttgaacaga tttgccgtca acataaacgt atgctaacag tcttccatac ttatctctgc 1732981 gatcgccttt atcaaattcc agctgtagct taccgctgtt gaccaattct ttatttcgtt 1733041 tcgacgcatc ctcaccgtat ggttgaacac aagaatttgg tttcttcgtc tcaggtgtat 1733101 caacgagcaa gtagcgaact gtgtctttct ttccgttgta aataacctta atcgtatctc 1733161 catctattgc tctatctaat gtaacattga ccaatttctt ctgatttttt gaatgaggcg 1733221 tgccagcctt ttgttctgtc tgattatatt cattagagtg agtatcttga gagacttgct 1733281 ccgtcccatt agaatctgaa tggtttttgg ctgcgtgatt tgatccgcaa gctgccaaag 1733341 taatacttaa aacgattgcg atcatactga tcaaaatctt cttcatattg attccctctt 1733401 tatcattttc tcttttcgcg attaaacatc atcattataa cgatatggac attttttgtg 1733461 aatggaaaac ttcaagggaa cttataacac tccaaattgc caatagttaa cttcacaacg 1733521 agatgatcaa aacatcacca tcacatagcg gaaataaata atcctgaaaa taatattgac 1733581 tgaaaatgct tttagaatta tgataatatg agaaatgaca ataatgtgac aaagacatta 1733641 ctacaacata acaactaata gcttaggttt attctattgg ttaaaaatgt aaacggttac 1733701 aaatccagag gcgaaaatct aagatagaga tgactttagt tttgactcaa tatccacact 1733761 gaaagagctt attaagtatt cttaaaggca ggggaaatgg atatgaatga acatcgaaat 1733821 cgaaggttga aattaataat gatttcagca acttttggag ggcttctctt tggatatgac 1733881 accggagtta taaatggagc tttacctttt atggcaaggc cagatcagct tgatttaaca 1733941 cctgttacag aagggcttgt tacgagtatt cttttattag gtgccgcgtt tggagcgttg 1734001 ttatgcggaa gattggctga tcgatatggc cgccgtaaaa tgatccttaa tctttccttt 1734061 ttatttttcc tggcatcact gggaacagcg ttagcaccta atgttttcat catggcggtc 1734121 tttcgttttt tactggggct ggctgttgga ggagcctcgg cgatggtgcc ggccttttta 1734181 gcagaaatgg caccgcatga aaagagaggg cgtatggtaa cccaaaatga actaatgatt 1734241 gttggcgggc aatttttagc atatgttttt aatgcgatcc tcggtgtaac aatggcaaat 1734301 acgggacatg tttggagata catgctagtc atttgtgctg taccggctat catgttattt 1734361 gccagtatgc ttaaggtacc agaaagcccc cgatggctaa tctccaaagg caaaaacagt 1734421 gaggcgctgc gagttcttaa acaaattcga gaagataaac gtgcagaagc tgaatgtaga 1734481 gaaattcaag aagcggtaga aaaagataca gcactagaaa aggcatcact caaggacttt 1734541 tctacaccat ggctgcgccg tcttttatgg attggaatcg gtgttgccat cgtgaatcaa 1734601 attacaggtg tgaactcgat tatgtattat ggcacacaaa tccttaaaga atctggtttt 1734661 ggtacaaaag cggctttaat cgctaatatt ggaaatgggc tgatatcagt tattgcagtt 1734721 atatttggga tttggctggt cggaaaagtg agacggcgtc caatattatt gattggtttg 1734781 gcagggacga ctacagcgct cctattgatt gcgattttct caattgtgct tgatggatct 1734841 atggcacttc cttatgtagt gctttctttg accgttttat ttcttgcctt tatgcaaggg 1734901 tgtgtaggac ctgtgacttg gcttgtcata gcggaaatat tccctcaaag gttaagagga 1734961 cttggttctg ggataagtgt ttttttcctt tggatattaa actttgtgat cggttttgct 1735021 ttcccgatct tgcttagctc tgtaggtttg tcttttacat tctttatatt tgtggcttta 1735081 ggtgtattgg caatcggttt tgtgtacaaa ttcatgccgg aaacaaaagg gcgtacactt 1735141 gaagaattag aagagcattt tcgttctcga cacgatcata atactcctga acaatcagtt 1735201 attgaggtat aaatatgttg aaaatctctc ttcttatagg agggattttt ttagtttcag 1735261 aaaaaacaaa atccctctgg tagagggatt ttgattcagc attttaagat gttctacacg 1735321 tataatactg gagttgatac tttaaaaatc tcgccatctc ttatataaaa acgagggatg 1735381 cggcggctta atgtagacac gacttcatag ttaatcgtat tgagcatttc agccacttca 1735441 tcaacggaaa tctcggctcc tttttgctta ccgtaaatca cgacttcatc tccttgttta 1735501 ccttcaccgt tttctcctaa actgaccatg atcatatcca ttgttactct tcccgccact 1735561 ggcactcgtt ttccgcgatg aagaacaaac ccgcgattgg aaagggcacg agaatagccg 1735621 tcagcatagc caatcgggag tgtagcaatt acttcattag gttctgcgat gtatgtagca 1735681 ccatagctaa cggttcgggg ttctgtccgc atggttttca cataagcgat gcgtgccttt 1735741 aaacttaacg caggttcaag cttaacgaga tttagttgtt taatataggc tgaaggatat 1735801 aaaccatata agccgatacc taaacggatc atatcagcgc taaattccgg aaatgcgata 1735861 gctgcagccg tgttgcacat atgcacggtg ggcagctcaa tcccctgttt ttttaaaaag 1735921 ctgagaaaac tgatgaattt ttcatgctgc agctttgtga gtgttgtgtc cggttcatca 1735981 gctgtcgaaa aatgtgtgaa aatccctgtc catctgagga atttacttgc ctttaaggct 1736041 ttcactacct ctaaaagttc ttcctttgtg cgtacaccta atcgtcccat gccggtatcc 1736101 acgttaatat gaatggccag ccggttagca ctcgcttctt tttccaatat ctcgtttgct 1736161 tctttcatcc aatcaacctg aaatgctgat aatgttatat tccaagctgc tgacttcttt 1736221 acacaactaa gggatgtaaa accaagcaca aggataggtg ctgtaatccc agctttacgt 1736281 aaaacgattc cttcctccac actggcaaca gcgagctcac tcgccccgtg ttccagtgca 1736341 tggcgtgcca cttctataga cccgtggcca taaccgttcg cttttacaac agccataatt 1736401 ttgctcttat gtggaatatg acggcggatc gctcgcaaat tctttttaac ggcatcaaga 1736461 ttgacttcga tccaaacttc tcggcaaagc tttatcatca acgcttcctt ccttcttatg 1736521 gattataaat accacctatt gccgcaagaa taaatgttaa ttgttggatg attcgatctt 1736581 attttattca actttatttg aaatcattca acagcaaatc catgtgatac gagaaggtgc 1736641 ctatcaatgt tcgaataata gcaagtacgg gatacatgag gcttgtaagt ggggtgttaa 1736701 tggatgcggc gaccgaggat tacaaaaatg attatttgtt ttgggacatt tttttctaag 1736761 ggtagatgat aacgagaaat ctaatcagga aatacttacc gttgttatga acattgaaga 1736821 accttttaaa tgagaagggc tgaggaaatt ctgtaaaaga taatcggttg aaaaggcagt 1736881 cgattccttg ttccataaac ctaacatcag agtatataat tatactcgta ttcacaaaaa 1736941 tcgtttaagt aaggggtata catgaatagg ggagttagtt ttcaaatacc gaatgaatat 1737001 ggaaattttc tatggagaat actgcagccg gtagaaatag ctaattatag gtggcaaacg 1737061 agtggggaat cttattttgt tgtagaagga gagctcgatg atgaggagct ttttcatgac 1737121 tacgaaattg ttgagggggc agtttttgag caacaattaa aaacgaatca gtactatacc 1737181 attttcgttg aactgaaagc atttccatat ggaaaaatgg ttaatcaagt caatacatat 1737241 gaagagtttg ctgacagtga ttgcgaactt gtccttttga tagcagataa tagctacgtt 1737301 tcgatttact gtaaaaacaa aaatatcatt gaaaaacttt acttcaatgc tttacagcat 1737361 gattttgaag acgttcaatt tataactgat gaaaatgaca caagaacaag ccttactgta 1737421 tgatactcaa taaaaattaa aggagctagt acatgacaat gcaaattaaa atcaagtatc 1737481 tagatgaaac acaaacaaga atcagcaaaa ttgagcaggg agactggatt gatcttcggg 1737541 cagctgaaga tgtaacaatc aaaaaagatg aatttaagct tgtcccatta ggtgttgcaa 1737601 tggagctgcc tgaaggttac gaagcacatg tcgtccctcg ttcaagtaca tataagaact 1737661 ttggcgttat tcaaacaaat tcaatgggtg ttatcgatga gtcatataag ggagacaacg 1737721 atttctggtt ctttcctgct tatgcattgc gtgatactga aattaagaag ggtgatcgta 1737781 tctgccagtt tagaatcatg aagaaaatgc cggcggttga attggttgaa gtcgagcatt 1737841 tgggaaacga ggatagagga ggactcggtt caacaggtac gaagtaaaca aaataaatcc 1737901 ttggctgtct tcatgctgtg tgattgatca atggaggttt cagccaaggt acatataaat 1737961 attatgtata aaatgaatat tttaatacga aggatttaat taaaaacaaa gtttaaaaag 1738021 ggaagttttg aaaaagtgaa atagtaataa ctaaagtcga taaagaacct aaagatgtca 1738081 aagaaacaat ttttctggtg ctttgctttt ttgaaggttt acttagctcg tggataactg 1738141 ccccccataa aagcatggat gctaaaatta taatacttat atacataaag atgctccttt 1738201 tattatattt acagttttta catttttatc gattttacca catttaggat tgagttgtcg 1738261 atgaaacaag catctctata aagaaatact tttatctaaa tttttataaa taggggaagg 1738321 caactaaaaa ctagtaatgc cactaataat aagccaagtt aaatgacttg tgttcattaa 1738381 taattgaatt ttacagcagc catgagcaca aaaaaatctg agttcgtcga taaatatcat 1738441 aaaaaagccc ccggtatgtc gccagggaat aaatagacgt ttaagagatt tagtgatgtt 1738501 ttttatatga ttcgacaaaa tcataataat gatcatcgtc atcataatac tttttttcgt 1738561 aatgataatc gtgatcatcg taatactttt tatcatggtc atcatacttt ttgtcgtaat 1738621 cataatgttt tttatcatga tcataatact tgtcgcaatc ataatgcttc ttatcattgt 1738681 cgtaatactt tttgtaatat gtttttttcc aagtataata ctcttcttta tattttttat 1738741 aataacccaa ttaaattcct cctttatgtt attcgaattt aatttatgaa gtttaaatga 1738801 tatggtatgg tcaaatgaaa taagaatagt aaaaagaggc tgtttaaaac actttctgaa 1738861 aaacaaaacg gatagctgtt tatgaaaata agagcgagag agagcactca atcactgtaa 1738921 aataatagta aagtgtatag agagattagt atacgtaaaa agggactttc tcattgaaga 1738981 atatttgaac gttatggtta agattcaaga gctctatgat gtgatttttc acactgcttt 1739041 tgaaggattt agagttagac atcaaaaaca aacagcaaaa ccggctagaa acagatcata 1739101 taaggaatga accgctgcca aatatcataa aaaagttgtt aatgatcaaa tgaatgaaat 1739161 tagagagaat ttattttaaa gaaagcccaa ttgcacatgg acaaatgaca attgatattg 1739221 aggtaaaata caatgcatta aatcagaaaa agctattgga ggatttaatg tgtttagaca 1739281 atttccaatt tggtatacac aaacacctga ctatttgaat ttttatgtac cgcaatatca 1739341 aaccatttcg tataatcctc aacaatgtta tcaacggtgt atgtaccaaa ctggcggtaa 1739401 ctatgagcta tgtgacagac tatgttatgg agaaatacag gtgtaaaaga gggggattaa 1739461 ctcctcttta aacacacagt gagtggaata agatcctcac tttatctgca agtgcttagt 1739521 atttgcgata atattgcatt cgtaataaat tatgcttagc aactgaaaat gaaagaagga 1739581 tatgaatagt catgacgcaa ttcgataaac aatacaattc aattataaag gatattatca 1739641 ataatggaat ctcagacgaa gagtttgatg taagaaccaa gtgggactca gatggaacac 1739701 cggcacatac tctaagtgta atcagtaagc aaatgagatt cgacaactca gaggttccga 1739761 ttttaacgac aaaaaaggtt gcctggaaaa cagccattaa agagttgctc tggatttggc 1739821 agctgaaatc taatgatgtt aatgatttaa acatgatggg cgtccatatt tgggatcagt 1739881 ggaaacaaga agacggaacc atcggacatg catatggatt tcagctgggg aagaaaaaca 1739941 gaagtctaaa tggagaaaaa gtggatcagg tagactatct tcttcatcaa ttgaagaaca 1740001 atccatcttc acgcagacac attacaatgc tgtggaatcc tgatgaatta gacgcaatgg 1740061 ccttaacgcc atgtgtatac gagacacaat ggtacgttaa acatgggaaa ctccaccttg 1740121 aggtaagagc acggagcaat gatatggcat tgggaaatcc attcaatgta ttccagtata 1740181 atgtgttgca gcgcatgatt gctcaagtga ctggttatga gcttggtgaa tatatcttta 1740241 acattgggga ttgccatgtg tacacacgtc atatagacaa tttgaaaatt caaatggaaa 1740301 gagaacagtt tgaagcacct gaactatgga tcaatcctga agtgaaagat ttttatgact 1740361 ttaccattga tgatttcaag ttaatcaact ataaacatgg ggacaagctt ttatttgagg 1740421 tagcggttta atgctgcctt tttattgtgc agtgaataga tagcaggtat cctaatttca 1740481 ttaagcaatc tggaagatga ataaaaattg aaggacaaac acgtataata cataaaaaag 1740541 attaactcta cagttaatct tttttattca gaagaaaata tcctaacttt gaaactaaat 1740601 acaaagtaaa agcaatcatt acagttctag atattacaat tccatgaata gctagatcat 1740661 atccagcagg tatcaacgca tttgtattac acataaaata tatagatatt agaagtgcta 1740721 caataactaa aatcattcca aaaagacttg ttttttcata tttcatacca atttccaccc 1740781 ttattaaagt taggtttaaa caaaagagct gaagaaacga actatgacca gtatgctcca 1740841 aggaaaaccg ccagacaatg ctggcggctt tttgctgctt cgtttattta ttaacagaga 1740901 tcgtaacgtt atttcctgca actgaaacct ttgcgaaatc ctgtgtatct accacaggag 1740961 tgacggcttt attgtcgata gtgatgttgt taaaagaggt cgaaaaggtt gctttgatcg 1741021 catcacgctg gctttcatac gaaacagccg cggtagcaag tgttttccat tttgaaatcg 1741081 tgccgatgtt ggttccttga atttctgtga taatccgtcc ggtgtagccg tcattgttcg 1741141 ttccccaaag ggtcatgcgc gtattgccgc ttaaattttt atagattgtc atttggactg 1741201 tgcttccagg gcggaagcct ttattgtatg tgaatttgtc ttttccttcg atgtacgttt 1741261 cttcattttt ggacccaacc ttcatgaggg gcttccagac gttgtattgt ttgctgtact 1741321 gaagcccgat atcggcttca gttccgcttg ttgccctaaa gccagaataa atatagggag 1741381 tagagaccga gtcgttgttt ttgacagttt caggaagcac gattttagct gtaaaaacgg 1741441 cgcccgtact gttcaggtag acacggccgc cgattccgtt aggcagctcg gatgctgctt 1741501 ttgcgacttg agcgtctgcc gcgggtaaac ctggtatacc tgatgaaagg gttccgaaaa 1741561 gaactgctgt tcctactgca cctgcaatca atactttttt caccaaaatt cccccttttg 1741621 atagtggttt cgccatttat tataccttat tttggaactg gatttacgta tataaatcga 1741681 caaaatattt cattttgaat gatgtaaggt cgaaacgctt cgccaatctg aaagctatat 1741741 acctttatca gaggaaagaa tgagatcaca ttcgttttaa ccgatttgaa attttcctca 1741801 aaataaaagt acaaatgctt aaagaaacga ttattaaaag aatgcccgct atcgtttcca 1741861 agcctgtaaa aaagaggtga cgtttcatca atgtctgtcc ttgtaaaatg ataaaagcac 1741921 agataccgac taagaaaaga aaacaaatac ttaggattgc taacgcttta cgtgagtatg 1741981 ttttcatttc atctttaaaa tacagcaata cgaaaataaa gcagataaca ttggctattg 1742041 ttctaatcac ctcaaagctt ttcatgacaa ctgatataaa tagacaaagt aaaatgagat 1742101 aaaatacgat gtttctatac aaaaaacctc tccttttatg taggatcctc aaagagttta 1742161 taaaagtttc tttgtaactg caataaattg aatgcgctca cttatgaact aactaaacta 1742221 tgtactaaat attcactatt ctttttcaga ttcagtcacc aaggttttca tagaaaggga 1742281 agcttcagaa atatacatat agtgcacaaa caaaaaagac ccggcaatag ccgggggaaa 1742341 gtaaaaacga ggagatgtta atggcgttta gtagtgtttt ttatgctttt tatactctac 1742401 aacataatca tagtcttttt tatcgtgatc ataatatttt ttatcatagt catcatattt 1742461 tttgtcgtaa tcacagtcat aatctttttt atcatattcg taatacttct tataatacgt 1742521 ttttttgacc gtataatact cttctttgta ttttttgtaa taacccatat atactcctcc 1742581 tttattttta ctacgcttta ttatacggcg agtagatttt gcggcttgga cagttaaaat 1742641 catagaagga aaaaagggct gtccaaatga tagaaaaaga cagatgacac aaaaacaaat 1742701 caaaataaag agccgatttt tcatcggccc aaacgattta tcctacattt gtttgtcttc 1742761 tttgttttct gagtcatttt ttctgatatc ctgagtcagt ccgcttgttg cttgtttaaa 1742821 ttctgataag gcttttcctg ctgcacggcc aagcgccggc agtttatcag gcccaaatac 1742881 taaaaaaccc acaaacaaaa taacgagtat ttttgtgaag cttaattcca tatccttttc 1742941 cccctgattg aagtacaacc ttttaaacaa attataagag atagcagtac aaatgggaat 1743001 gcatttattt tgaacatttt aaaaccagca caaagacgga ttcataaaac ggctgctgct 1743061 gaatataatg tccaatgcca cctgcctaag aagcaggagg caggctggat caattatgta 1743121 gctctgccgg aaatgataca aacgtagcgg ctatcattga catagaggag tggtgtagct 1743181 gatgagattc actaaggtag ttggattttt gtctgtttta gggttggctg cggtttttcc 1743241 attaacggca caagcagaaa aagccggaac tgcgggggct ggagagtggg ataagttggg 1743301 gacttacaca tatacttact caagtccgac ggtatactcg accggaggag attttagagt 1743361 gtgcctttca ggaagcactc ctttttctgt ttcactgcac ttatatgagg atgatcccgg 1743421 tgacaatcct gatgattatg taggggcaaa ctatttttca cccggagaat gccacacctt 1743481 tggcagtatt ggaaaatttg tagatgggag caataacaag gccgagttct ttgttaccga 1743541 ttactctggt aaatctaaaa ctgttacgtt ttatgattga tggactcaaa ttgtgaagta 1743601 taacccttgg aaaaaaacaa aaaagagaga tacctctctc ttttttattc ttcgacagcc 1743661 ttacgaagcc gttcatttac aatgccagtc cagccgccat ccatcttacc gcgaacgacg 1743721 gagcttttct cgtttgcttt gccgatcact tcattcggct ctttccagcc gctgtgaata 1743781 agggtaaacc ctgtcttttc ccccaagtct tctaattgaa aggtaacgac ccatccttct 1743841 gtatcccatt caaaagaaag ttcagttgga gcttgaacag ccaaaacttt acaaggggac 1743901 ggcccaaacg gcgattgtaa gtgaaattct tgtccttctt tgagctgaaa gtcattgggc 1743961 ataaaccact tggcaatgcc ttctgaagta gagactgtct cccagacttt ctgaatggga 1744021 gcctccagag taatgctttt tgtaatatcc ggtaatgcat tttcgttgtt ttgagccatt 1744081 tcgtttacct cttgacatat gatgtttttt caattcaatc atataataac taataagatc 1744141 atgtccatag cgtgcattat ttatgctaga gctgctgttg aacagcgtgt cagtcgccag 1744201 tctgatctgt gaatgggaga attctgcatg cgcgaaaaag agagagaggt gtatgttgtc 1744261 atttcgttca ttcttgtttg cagccgcaac tgttatgttt gaactgggat tcctgttcag 1744321 ccaatttatt ttgcgatttt tgttttaata gtaaatgagc cattttctaa aacaggaggt 1744381 tttttatgct tggaaaaatc aaagcagcca ttgataatag tccagggaag ccggccagaa 1744441 ttttagttag tgaaaaagcg tttcagcaat tagaggaaga aatgcgcttt gtttacgttt 1744501 ccaaaccgaa aacgataatg gggattcctg tggaagtttc agatcaggca gaaagcttca 1744561 agctggaatt ttagttttcc cagactgcta aaaggctcat tttgtgttaa ttatgcaaaa 1744621 tggtcaggtt gatttcttta aaagcatgat gaaatgttca tcatgctttt ttattgagaa 1744681 aaaagacgaa cataaaaaat aggtatacgg gaaaaataat cctattagag agaggggaac 1744741 tgacagatgg ataacatgat atcaacactt actgactgga atgtgtggtt tcaagcgtta 1744801 gtagtatttc tcgttccata tgtaatctat aaagtgttta cttggattca tgtataagaa 1744861 ggtgcaatga tgaggtggcg gaacaatcag tacaaaacac agaagcagca taaatcagat 1744921 tattcgacag ctgaaaagca ggatcaggat gtgttaaccg gtaacatcgg atacgactta 1744981 gaacatgtaa aaagaaaaat aggacataac ggggacgttc atttccgtga gcttgaaatc 1745041 actcaattac atgtgaaagc ggcattgatc tttgttgaag gactgtctga tcaggacttg 1745101 attaataaag gactatcagt gttagtcatg aatcaaccta atcaggtaag cgatgaaatt 1745161 tctcaatccg gcaaaggtat tttaacttcg aaacagataa aaaatcaaat cgtatcaatc 1745221 ggtgatgtca tagattcaga gaaaatcagt gatatcgtgt tgaatgtttt catgggttcg 1745281 acagcgcttc tcatcgatgg aataccgcag gcctttcttc tgggaactgt aaaaaaacaa 1745341 aatcgaagta tcgaggagcc gctttcagaa gcgcttgtca gagggccgcg cacaggcttt 1745401 acagaagagt tgagtacgaa tacagctctt ttgagacagc aaggaaaaaa tgatcaatta 1745461 acattgcaga gatttgaagt aggaacacga ttaaaaaagg atttaattat cgcttatatg 1745521 aatgacattg cagatccaaa agtagtcgag gaagtaagaa aaagagtgag agggattgag 1745581 atcgatcatt tgccggagtc aggctacgtt gaacagttaa ttgaggataa ttatttgagc 1745641 ccgttcccgc aagtacagag tacagaacgt cctgatcgcg tcataagcgg attaatggaa 1745701 ggaagagtag ctattctgct tgacggcact ccgtttgctt tgattgttcc agtcactttc 1745761 agcatgatgc ttcaatcgcc tgaagattat tatgaacggt ggttcccgag ctcgctcatc 1745821 agattgctga ggttcatcgc agcaatgata acgttattcg cacccgcttt atatatatca 1745881 tttatttctt ttcatcctgg gttaattccg accaagctgg cgatttcaat ttccgggacg 1745941 cgccaaggtg ttccgttccc atctctgatt gaagccttat ttatggaagt cgcgattgaa 1746001 attttaagag aggcggggct tcgtttgcca aaaccaattg gacccgcaat aggcatagtt 1746061 ggcggattaa tcatcgggga agcagctgtg caggcgggga ttgtcagtcc aatcatggtc 1746121 attgttgttg cgctcacagc aatttcttca tttgccatcc cgcattatag cacaggtata 1746181 gcacttcgga tgcttcggtt tggcgcgatg ttttgtgcgg cggtgtttgg attgtttgga 1746241 gtcattatgt attatctgct gctaagcagc catgtcgtaa agctaaagag ctttggtgtg 1746301 ccatacgcaa gtccggcagt gccctatcac ttaaaagatt ggaaagactt tgttatcaga 1746361 atgcctcttt tagtcatgaa gcgccggcct aaaatgatga atacagataa tacaaaacgg 1746421 gtgaagtgat gaactcgaca ggatggtgat aaagtctcat gttcagccca accagtaaaa 1746481 tcacaaccgc tcaggcaacg attatcatca ttaattatat gcttgctgcc ggagttctta 1746541 cgctccctcg gacagtaaca gaacaaacac aatctcctga tggatggatt tcagttttat 1746601 taggcggggt cctagcggta atagccggga tgattatagc taaattaagc cagcagtatc 1746661 ctaaggagac cttttatgaa tactcccgac atattgtagg aaaatggctc gggcatctga 1746721 tcagtattgt ttttattact tattttctgg cactcggtgc atttgaagtc agagtcatgt 1746781 ccgaaatcgt ggattttttt ctcctcgaag ggacaccttc ttgggccatc attatgacag 1746841 ttctttggat tgggctttat tcaattacac aaggcctaga tccgattgca cggctttttg 1746901 aaatgatttt tccgattacg gtcatcatct ttttaacgat agccctcatg agtttaggca 1746961 tatttgagat caacaatttg cgccctgtat taggtgatgg aatcatgccg gttcttagag 1747021 gtgtaaagac aacgaacctt tcatttacat gttcagaaat tatgttcatt ttagtagcat 1747081 ttatgaaaaa gccgaaaaat gcggtgaaag cagttgtgat cgggacaggc gttgtgacca 1747141 gtttttatat gattacgatg attatggtca tcggtgcact atcagttgag ggagttgtga 1747201 cgagaacatg gccggggctt gacctgatga gaagttttga aatacctggt ttaatatttg 1747261 aacggtttga atcatttctg cttgtgattt ggattatgca gctttttgcc acgtttatta 1747321 tcacttttta tgcagcttcc ctgggagtct cacaagtttt taaaaagaaa cccctttcat 1747381 gtatgtttgg gctgcttcct gttatatata tcctctcttg catgccgaaa aatgaaaatg 1747441 acgtctttat attgggcgat acggtcagtc atatcgcttt gtatatattt ggcgctttgc 1747501 cgattttgct gttagtcatt tcgaaatgga ggaaaagagg tgaaaagtaa actaaaacgt 1747561 caattgcctg ctatggtcat agtatgtctg ctgatgattt gcgtaacagg atgctggagc 1747621 agtcgggaaa tagaagatct gggtctcaca ttcgctatcg caattgataa aggaaaagaa 1747681 acgaacactg aaaaagagtt aaaagaagag ggcgggagct atccgaaaaa agacaacatt 1747741 acgctgacct atcaatttgt taatgaaaaa gcggcaggcg cgggcacaag cgggggaggc 1747801 ggtagcggac aaggagcgca aaaagcgtac attaatataa gtgaaacagg ggattcatta 1747861 cagcagatcg gaagtgaggt tgcattaaga cgggaccgag aagtgtttag cccgcattta 1747921 aaagttgttg tcatgagtga agatgtgctg cacacatttc ctatcgacga aatgctggat 1747981 caattttttc gtgataatga aatcaggctg agctgtcttg ttttatctgc taaaggggaa 1748041 gcaagagacg ctctccagct gaaagagaac ggagaaattc cggcatttcg gctgattgga 1748101 ttaggtgaaa atgaacataa agtttccaga attcttcccc ctatgacact cgcgaaacta 1748161 attggaaaac tgcattctgg cagcagcttt ttactgcaaa atgtggttgc ggcgaatgga 1748221 gcggtcaagt attccggagc agctgtaatc aacggaaaat cgaaaaaaat gataggcacc 1748281 ttaaatgaat atgaaactga ggggattaca tggattagag gagaagggaa aggcggagtt 1748341 gtcaaaagtc atgataaaaa gagccaacag acgttagcgt acgatatcaa taaaatcaaa 1748401 agcagaattc agccaatcgt aaaagggaaa gatatttcat tccatgtcga tattgaatca 1748461 gaaggcgatt tggttgaaaa ctggaacaca aaagaggcgt tggacaccca gtttatagat 1748521 cgtctcgaaa cgactattga aaacgaggta aagaaaatag ttggtcaggt attaaaaaaa 1748581 attcagcatg attataaagc agatgttgcg ggttttgatg aatcttttag acttacatat 1748641 cctcacttat ggaaaagggt gaaaaataac tgggatgaca ccttcagtaa agccgacatc 1748701 acatacagtg tgaacgtcac aattactcat ttcggcacgg ttaaaactca gtaatgaatc 1748761 ccaaggaaga gaaggaaacc tctcttctct tttttatgca tttattagga taaagatact 1748821 ttttttggag agatatacac ttttcaaatc gaccaatatg ctaatatagg aattgcttga 1748881 aatagaaggg agaaggggct gtgaggcaga aaccgattta tgtagaaatc gaaatgaaat 1748941 ctgatctgga tacactctgg gaatatacac aaaacccatc actgcataag gaatgggatc 1749001 tccggttttc aaatattacg tatttgaata gtcagccatg cgaaaaacag aagtttcttt 1749061 acgaaacaag ggtaggcttt ggattaaagg tgtcaggtac aggagaaacc gtcggtgttt 1749121 tcaacaaatg ttcatctgaa aggtcttctt cactggcttt tggctctgat catccattat 1749181 ctctgattcg gcatggaagc ggctactgga agtatataca gagagaaaat gggaaaatga 1749241 cgtttttaac acagtaccaa tacaaaacag cctacggact gctgggaaga tggattgatc 1749301 gtttattatt tcggccgctg cttggctggg cgactgcctg gagctttgat gcattaaggc 1749361 tttgggtaga gcaaaataaa catccgaagc gcttcattcg atctgctatc atctatgtgt 1749421 tcatgtgtct gtttttcagc ctgttttggt tctatcaagg ctttgcaggt gttaagacaa 1749481 gcatattgac aggaacagcg gagataggct tagctatttt gtggctgctt cctttaaaaa 1749541 gaaaatggat cattcatggt gtccaggctt gtatttttgc tgggtttgct tgtctaggtt 1749601 ccgaaatatt catgtgggtt ctattgagtg tgttttccgc tgcaagcggc gctcttagcc 1749661 tgcagctccc cagtgccagg cgcacaaaac gaaagagaaa gaagtgacat tgtgagttcg 1749721 atttatgaaa aatcaattat taactatcat ttgctgcatc ccaagctgca gaaacggtac 1749781 caattagacg ggtctcatac attcagcggg acgggaacga tgtcagaaat aagcggaggc 1749841 tcttttctgg ttagaatgct gttaaagctg ggtgtttttt tcagatgctt cttttcagaa 1749901 agaggcaaag acattccatt tacaatacaa aatagaactt gtcttttgaa atcgcaacat 1749961 acaggaatag aatggaatcg tacatttttc tttaaaggca aaaaacgttt ctttgatgcg 1750021 ttaatgatat atgacgagaa agaaaataga atacttgatt tcttcggcaa acctcatctg 1750081 ctgctgtctg ttttgacgtt cgaggcatct cttgacggct ctcttacgat cacatcggga 1750141 aagcaatggc tattgatatg cggaaaaaga atcccgctgc cgaaatggct gaccggtaca 1750201 tccgaagttt gcgaaacgtt tgatgaaaaa aagaattgtt tcaccattga agtgcatgtg 1750261 caaaatacaa ttcttggcac tcttttcttt tataagggaa cgtttcagga ggaagagaga 1750321 gaatcatgaa acgaaatggc atagtcagtg cgctttgttt tattggattt cttgcagcag 1750381 aagcaccgga tatttcagtg gcagaggcac tcgttttgtt atccattcta tttttcgtgc 1750441 cgggaatttt tccttttgtt tttcgtcaat ctccggttcg tgctgctcag tttatggaaa 1750501 acgggctaat ccagtgctat cctgtagccg cattctttgc ggtgctggct ctagtgacgg 1750561 aggttggggg tttcgcactt atctggtgga tgtacacagt ttttaatgca ttgtatgcga 1750621 tcctccgcct ttgggaaaca aagatacata gaatcgaaga gacatcagtt ttgttcggtc 1750681 ttatttattt ggcgggagga ggattttggt tttttgctta tgctgcccat ttgcagatca 1750741 tgcaatttgg ccctctcatc attttgctga ctgctgtcca ctttcactat tctgcttttc 1750801 tgatcccgat cttcaacggt ttactcggca gaaccattag aaaacatcgg atgttgtaca 1750861 gttggataac atgggtgatt ttgctttcgc cccttcttat cgcactgggc atcacatatt 1750921 caaaaacact tgatgtcatt gcggttagca tttatatggc ggcgatttat cttcatgcat 1750981 ttttggtgtt cacggcagct tttcgcacca agacggggac atttcttatt cggctttctt 1751041 ccgctgtttt aatgataacg attgctttct cgatgattta ttcatttggt gtctttcggc 1751101 aagaagttac attgaccatc aatcagatga tttggattca cggttttgtc aacgcgtttg 1751161 gtgttatctt gcccgctctc atagggtgga gaatagagga tgcgaaacct tttgatgcag 1751221 acagtgtaaa gacattcagc cgtatctacg gaaaaagaaa gattggagaa gaatttttag 1751281 ctaacattca agctgaaaat aacgctcggt acagcggact tgtggatgat atgggcagcc 1751341 tgcgttcaaa agatttttca ccagaaaaac tggcgccgct cattctttcg ttttatgaac 1751401 aaaccatcga atacaatatt aaagcaaaag taacatggag cacgtggttt cggccgcttg 1751461 caattattta cgaatggttc agcagaagaa tcggccaaat acatctttcg acgaaccctg 1751521 actggtatag gatgtacagc aagataaaag gtgttcattc gaaaaaagac ggaagggaaa 1751581 gagtacgtgc ctggattaga acaaatgaaa aaaacgaaac catttttacc gctctttatt 1751641 cagtgtatcg ttcaaatgga gaggggtata tgaatatttc tttaccgctt ccattcagca 1751701 gcatgacagg tattttaaaa ccatatcatc atcaggagaa gctggtttta acaagcaggc 1751761 ggagaaaaag cagagcgggg gatgagggga tttatctgca aacaagagcg ggaacttgtc 1751821 cgcttccttt atctgaaacc tttctgatag aagctgtaca tgacaacaaa ttaaccgctg 1751881 ttcatcatat gtggctgttt ggaataaaat ttctaactgt tcattacagc attacacata 1751941 ttaaccagcc tattgaaaga acctaacaca aagaagaagc ttcgtctgcc agttgtaatg 1752001 agatgaactg ttttaaaatt ctgcaccgca tcaagacagg aaaggaaggg tttatggtgt 1752061 tttatatcag tttatttctg attctttggc tggctgctgg gtttgcagtg ggaatgaaac 1752121 aagtgtatgt cgatcagctg tttgataaag ctgtgatcga aagactggaa aaagaagcga 1752181 atgatcatgg acatgctgac cggatgatca aacagcgcgt cctttatatt gcagcagtga 1752241 cagtaagcgg gtttatttct gtttattatg aaatgaaaac aatcccgcaa aggcgaaaca 1752301 taagaaaaat tgaaaaaaac atcatgaaat taaatcaagc aaaaaaacga agaatgaaga 1752361 gaaaataaaa agtgcacagg ccaaagggca ggtgcatttt tgttttgtat ggaaaatggg 1752421 ggaggtggtg ccagcttact tttcataaat tcaaaaatga gaagaacagc gcccgggcta 1752481 atggtatata atattgtgaa tttaacaaaa atttaacaag gaggacgaga gaattcgtgc 1752541 taaagcctca aagagaccta cattctgttg atttggactt agaggcggag tagatgaaac 1752601 cggccaaagt atccctgctc cgccgtttgc tccattcctt gaagcatgtt gattgtaaca 1752661 tagccaaacg ttttccatca actattaaaa ttgtaaaatt attgatgatt tttatggtgt 1752721 ttactccgat ttcttcaatt tatgctgaag atgtatatca gaattttgag gaattaaaaa 1752781 acaatgaaga tccttctgat tatggcgttg ttacgaaaga aaccggaagc cctgttcttg 1752841 ttttagctat tcacggagga ggtattgaag gcgggacaag tgaagtagcg agagagctca 1752901 gcaaagagta ctcgatgtat ttatttgaag gcttaaaatc ggcaggaaac tcagtcctgc 1752961 acattacgag cacacacttt gatgaacctc gggcccttaa aatgacggga aatcatgaat 1753021 atgtcatttc attacacggg tacgcagaag aagatcagca gatcgaagtc ggcggtacag 1753081 atcgcgtaag agcggcagat ttagttgaga aattgcagca tgccggtttt cctgctgtat 1753141 tgctcaatat ggaccatccg catgcgggcg ttagtccgaa taacattgca aataaatcaa 1753201 aaacaggttt aagtattcag atagaaatga gcacagggtt tcgaaagtct ttgttcggca 1753261 tcttttcttt aaaaagcaga gctgttactc aaaatgagag gttttatgag tttacagaag 1753321 tgatgttccg ttttctcaaa aatagctact gaaaaatagg aggcgataag acagcctcct 1753381 attccttatg cttctctttc gtttcgggaa acagctcgtc cgcggcttcc gtttgatact 1753441 gcaacgtgtt atctctcgct gacagttcat ttcggaaatt ttcatcaagc acatttttca 1753501 gtaaataccg atgaaaaaag tattcaaaaa cagtaagaca ggcagcggaa aggagagccg 1753561 ctccaaatgg tgagaaatcg tttcttgttt gggttaaaac aaatacccaa agaataacga 1753621 atgaaaggcc aaagtcagcc aatgaagctg taatattgtt tgttctgggt aagacgagca 1753681 tgtcaccaga aagataggaa acaaaaccta agaaaagtgc aataaacatc acacttaaaa 1753741 aggatgcgtg atagactctg tccaaaatca catataaaag ggcgagagtg aaagcaatct 1753801 ttgaagcaag cgcaatgata tgtttcattt gaccacctaa attgttattt tttgaagaaa 1753861 attcttgggc gtaaacaaat gataaataat gcaattcaaa accattcata atggtcatgt 1753921 tactatttta aacagtccgt ttttgtttac actggtattt ttttcagctg tatgaaactt 1753981 tcttatgaaa aaagtcgtat atgtggatga tcagctttca aggggggaat gatttgtgga 1754041 gataaaagga atcaatcact tgctattttc agtttcgcat ttggatacat cgattgattt 1754101 ttatcaaaaa gtgtttggtg caaagctttt ggtaaaggga agaacaactg catattttga 1754161 tatgaacggc atctggctag cgcttaatga agaaccagac atcccgagaa atgacattaa 1754221 gctttcttat acccatattg cttttacaat tgaagatcat gaatttgagg agatgtcagc 1754281 taaattaaaa agacttcatg tcaatattct gcctggcaga gaacgagatg aacgcgatcg 1754341 aaaatcaatt tattttaccg accctgacgg ccacaaattt gaatttcata ccggaaccct 1754401 tcaagacagg cttcgatatt acaaacaaga aaaaacgcat atgcactttt atgatgaaac 1754461 ggccttttga tagcacaacc atatttcata taaggttaaa tttaaagaag ggtgttggtg 1754521 gagactttat gtttggggaa ggtttctacc cgacttgttc aacgatgcca tatcttttga 1754581 actgcacaag tgattgggtg aaggtgaaat tgaaatacac attacattac attttatatg 1754641 aagaaagcga gctgttttat caaatgttga actaattaaa ctatgtacta aattttcagt 1754701 atatttcaat tgctttgccc cttaataaat ataaaaccgc atccttccac gacctaaaaa 1754761 atgaaacgtt tttaagaaga tggcgtctaa tattctaaat gttcatattt tgataaaagt 1754821 ttcctaaagg aaagaaaatt tcttgacttc aacaatcttt tggtggataa ttatggtgta 1754881 aacatgatgt tctttttcct cctattcggg ctcgcaccca aaagtcaggg cgagcctgct 1754941 ttttttgaac aacaaacccc ctctccgtaa aggaagaggg ggttatttta tgcatctgat 1755001 agatcaatag attaatggac ggttctgaac acgccaatca ctttccctag aatgctgaca 1755061 ttctgcaaaa tgataggttc catcgttggg ttctcaggct gcaagcgaat gtgggtatcc 1755121 tctttataga atcgttttac agttgcttca tcatcttctg tcatcgcaac tacaatttcc 1755181 ccattgttcg ctgtgttttg ctgtttaacg atgacatagt ccttatcgag aataccagca 1755241 tctatcatac tgtctcccat aatctccagc ataaatacat gctcgtctgg aggaaccatg 1755301 cggtcaggga gcggaaaata ttcttcaata ttttctactg ctgtaatagg agatcccgcc 1755361 gtgactttcc cgatgaccgg tacattaacg acctggcttt gcggaatgtc tacttcttca 1755421 tcaagaattt ctattgctct tggttttgtc ggatctcgtc tgatcagccc ttttgtttcc 1755481 aaacgggcca aatggccgtg gacagtagaa ctggacgcaa gcccgacagc ctctccgatc 1755541 tctctcacgg aaggcggata tccttttgat ttaacctctg ctttaataaa acggaggata 1755601 tcaagttgcc tttttgatag cttcgtcatt tttcgcacct caaaacgtcg attttaagaa 1755661 gattatagca tgattttcct tacagtacaa acataggttc gaaaaaacaa ttgacagaaa 1755721 cgtttgttcg tatatactga aattataaaa atgcgaacaa acattcctgt tggaggttat 1755781 gatcatgagt aaagaatcta ttatttttgt cggtctgttt acagtgattt tgagcgcggt 1755841 tatccttatg ctgtcatata caagcagcgg ccaagagctt aatcagtatg ttaaaataga 1755901 agtccagcaa ggcgacacac tctggtcaat tgctgatcag gtagccgata caaaaaagat 1755961 aaacaaaaat gattttattg aatgggtagc tgataaaaat caacttcaaa cctctgatat 1756021 ccagccgggt gatgagttag tgatcccatt gaaaaagaag catcaggatg catatgaatt 1756081 agcaactgta agatagagag gaaagagaga taaaatgaaa gcactcattt atgcccgtgt 1756141 aagcacaaat aaagaacagc aggaaacgtc attaaagcgg caggaggagg agcttacggc 1756201 cattgcagcg gagaacggca tggaagtggt caaagtgatt tcagaaaaag ccagcggata 1756261 tgaaatggat cgggatggtg tatttgagct gctcgatgag attaagaacg ctgatattga 1756321 tgtcattttg gttcaggatg agacaaggct cggacgggga aacgcaaaaa tcgcactgct 1756381 tcattgtatt tatagagaag gtgtgaaagt ctatacaacg gctcatagag gtgaactgga 1756441 gttatcggag gctgactcaa tggtcttgga aatcgtcagc attgtggaag agtatcagcg 1756501 aaagattcac aacatgaaaa tcagacgggg aatgaaacgt gcagtaaaaa acggttttaa 1756561 accgcaaaaa aacttaaaaa accaacatgg gaacagtgga aaagaaaaaa tagaggtgcc 1756621 aatctcagag atcgtccgcc tgagagcgaa taaactgacg tttgctgaaa tcgcggctac 1756681 cctaagaggg tttggctatg atgtctctaa agcaaccgtt caccggcgtt ttcaggaata 1756741 catagagaat gaagagactg cagagtgaat cagttgtaaa actttttttg atctagtact 1756801 atatagacaa aatgcaataa aggagtttaa catgatttca aacgcgaaaa ttgccagaat 1756861 taatgaactt gctgccaaag ctaaagctgg cgttattaca gaagaagaaa aagccgaaca 1756921 gcaaaagctc cgtcaagagt acttgaaagg ttttcgttct tctatgaaga acacgttaaa 1756981 aagtgtgaaa atcattgacc cagaaggcaa tgatgttaca ccagaaaagc taaaaagaga 1757041 acaaagaaat aacaaacttc actaatataa gaggaatacg gcaatatcgt attcctcttt 1757101 tgcatatact ataatcaaaa ctcttatgtg acaaaattca acaagtttct ctcaaattta 1757161 agctgaaaca gttgagaaaa agtcgtcaga catttatgat gtaagggtac aacacataag 1757221 gaaggggatt tttatggata caattgaaaa gaaatcagtt gctaccattc gcacactgtc 1757281 aatagacgct attgaaaaag caaattctgg tcacccaggg atgccgatgg gagccgctcc 1757341 aatggcatac acgctgtgga caaaatttat gaacgtaagt ccggcaaacc ctggctggtt 1757401 taaccgtgac cgttttgttt tatctgctgg acacgggtca gcactattat acagcatgct 1757461 tcatttaagc gggtttgatc ttagtattga agatcttaag ggattccgcc agtggggcag 1757521 caaaacacca ggacatccgg aattcggaca tactgccggt gttgatgcta caacaggtcc 1757581 gcttggccaa ggaattgcca tggcagtcgg tatggcaatt gctgaacgcc atttagcgga 1757641 aacatacaac cgcgattcat ttaacgtagt cgatcattat acatacagta tttgcggtga 1757701 tggtgattta atggaaggta tttcttctga agccgcttca ctcgcaggcc atcttcagct 1757761 tggccgtctg atcgtactat acgattctaa tgacatctct cttgatggag acctcgaccg 1757821 ttcattctct gaaaacgtga aacagcgttt tgaagcaatg aattgggaag ttctttatgt 1757881 tgaggatgga aacaatattg aagaattaac agcggctatc gaaaaagcac gccaaaatga 1757941 aaagaaacct acattaattg aagtgaaaac gacaatcgga ttcggttcac ctaaccgtgc 1758001 cggtacatcc ggtgttcacg gtgcgccgct tggtaaagaa gaaagcaaat taacaaaaga 1758061 agcttacgcg tggacatatg aagaagactt ctacgttccg tcagaagttt atgagcattt 1758121 cgctgtagct gttaaagaat caggtgagaa aaaagaacaa gaatggaatg ctcaattcgc 1758181 taaatataaa gaagtttatc ctgaacttgc tgaacagctt gaactggcaa tcaaaggaga 1758241 gcttccgaag gactgggatc aagaggttcc tgtgtatgaa aaaggaagca gtttggcatc 1758301 ccgtgcatct tccggtgaag ttctcaacgg acttgcgaaa aaaattcctt tctttgtcgg 1758361 aggttctgct gacctagcgg gatcgaacaa aacgactatt aaaaatgccg gtgattttac 1758421 agcggttgat tactcaggca aaaacttctg gtttggtgta cgtgaatttg cgatgggtgc 1758481 ggccttaaac ggtatggcgc ttcatggcgg tcttcgtgta ttcggcggaa ctttctttgt 1758541 cttctctgat tacctgcgtc ctgcgattcg ccttgcagcg ttaatgggcc ttcctgtgac 1758601 atatgtcttc acacatgaca gtattgcggt tggtgaagac ggtccgacgc acgagcctgt 1758661 tgaacagctt gcttcactcc gtgcgatgcc taacctttct ttgatccgtc cagcagacgg 1758721 caatgagaca gcagcagcat ggaagcttgc agtgcaaagc actgaccacc caacagcgct 1758781 agtgcttaca cgtcaaaacc ttcctaccat cgatcaaaca tctgaagaag cattggcagg 1758841 agtagaaaaa ggtgcatatg tcgtttctaa atctaaaaac gaaacacctg acgctcttct 1758901 catcgcttcc ggatcagagg taggtcttgc aattgaagcg caggctgaat tggcaaaaga 1758961 aaatatcgat gtttctgttg tcagcatgcc ttcaatggac cgttttgaga aacaatctga 1759021 tgaatacaaa aacgaagtcc ttcctgcaga tgtgaaaaaa cgtcttgcaa ttgaaatggg 1759081 ctcatcattt ggatggggca aatacacggg gcttgaaggt gacgttctcg gcatagaccg 1759141 attcggtgca tctgctcctg gtgaaaccat cattaacgaa tacggcttct cagttccgaa 1759201 cgtagtgaat cgagttaagg cattaatcaa taagtaagct tttgaaagag gatgagtcaa 1759261 atcatcctct ttttcttgtt tatccgacaa aaatagtatt ggctgtttaa cagtaataga 1759321 caattctttc ttttcttctt ttgtataata gagagcaaat gaaatgctgc tggaaaaggg 1759381 gatgaaaaga tggaacgtca ctactatacg tacctgatca aagaggaatt tgccaatcac 1759441 tatttcggcc gggaatcggt tatgtttgag ctgtttcaag actatcattg gacaagcctt 1759501 gaaaagcagc agtatgaaat gacagagaaa cagattcaat atattacaca accaatcccg 1759561 attttacata tgcatcagcg gttaaaaatg aatttaaaca agacggatta caggcagctg 1759621 gattatattt atagaatagc tttgccgaaa gcaaaaggcc acgcgacgtt tatgatgaag 1759681 gagcacatga tagaaattgt ggcttcggga gattacgagg cagaaacgat attctttgaa 1759741 gtgttaagaa aagtaagccc ttgcttttta gcaatggatt tcaattcgaa gcgttacgga 1759801 tggctaaatc cggtgaaaga aagaaatttt gtctaaaacc gaagaaaaag agatgtaaat 1759861 gttgtataat agcttttggt ttagtacact ttaaactaga caacatgaag gaggaaataa 1759921 aatgacttta tgggttggca tcctagtggg cgttgttgca ttgctcatag gtgttgcact 1759981 cgggtttttt attgctcgta aatatatgat gagctacctg aaaaagaatc cgcctattaa 1760041 tgaacaaatg ttacgcatga tgatgatgca aatgggaatg aaaccttctc aaaagaaaat 1760101 caatcaaatg atgaaagcca tgaataatca aacgaaataa tacgtaaaga ttatgatata 1760161 gagaaacatg gttataaaat aaaaaaccct tatacgggtt ttttattttg caatcattca 1760221 tcacccgcta ctgctcgaag gcgctgcttt tgatattgta tgagaagatg gtcaagctcc 1760281 tgactgagct ctatcgtaat atgagatgtc attccgttcg ccatgacaat ttgcagcagc 1760341 tctgctcttt ttttttcaat ttcttttaat agatgctctc taatcacagg gatgtatcct 1760401 ttcatacatt agatcttcaa agtgaatgtt tatattatat ccatatttat actaattttc 1760461 aaatgagaag gagtataatg tctcaatgtc aaattaaatt atataagttt tttctgaaaa 1760521 tagaaatcct tcaagtgaaa gtgttaaaaa aatgaaatga ttttgtcata acttgaagga 1760581 atgtcaaatc atgaagggat gatgacatgg gagacgtgaa ttattttttg acattcggag 1760641 cggggttttt atcctttatt tcgccttgct gcctgccgct ttacccagct tttttgtcat 1760701 atattacagg ggtcagcatg gacgatgtaa aaactgaaaa gctgctgctg cagaaaagaa 1760761 gcttgtttca tactttgtgt tttttgcttg gcttttcagt catttttatt gctttaggct 1760821 atggaacatc ttttattggc agcctgttta gggattatca cgatgcgatt cggcaaattg 1760881 gcgcgttgct tattattttg ttcggtttca ttacactcgg tgtgttccgg cctgaggcta 1760941 tgatgaaaga gcggagaatc cattttaagc ataaaccaag cgggttttta gggtcggtct 1761001 taatcggaat ggcatttgca gctggatgga caccatgtac cggtccgata ttagctgctg 1761061 ttatcacact tgcaggcacc aatccgggct cagcggtgcc atacatgatg ttatatgtac 1761121 tcggttttgc ggtaccgttt cttttattgt ctttttttat cacaaagctg aagtggataa 1761181 ggaagaacca gcttttcatt atgaaagctg gtggcgtttt gatgattgtg attggtgtgc 1761241 tgttattctt taattggatg agcctgatca ttattttgct gtcagatctt tttggaggct 1761301 ttactggttt ttgacggtaa attactttcg tactactact aatccttttg tttttggtac 1761361 aataagacta ttatctgtgg aaatcgattg ttggagggga atatgacaag agttttagtt 1761421 gtagacgacg ccaagttcat gagagtgaaa atcagagaga tcttggaaga ggcaaattac 1761481 ataatcgcag gcgaagcggc ggacggtgaa caagcagctg acctgtataa aaaactgcgc 1761541 ccggaccttg tgacaatgga tattacaatg ccggtgaaaa acggcataaa agcgcttcgt 1761601 gatatcttaa cctttgatcc taaagcgaag gtcatcatgt gcaccgccat gcgccagcaa 1761661 agaattgtaa cggaagcaat tgagctgggg gcaaaggatt ttattgttaa gccgtttgag 1761721 gaaacaaaag tgctggaagc tgtaagccgc gttatgggac attaaagtca tttcttttca 1761781 aaatggtttt ttttattgtt ttggagtata gtatatagta tcaacactcc gagaaacaaa 1761841 ggaatgataa gtatgatgat tatagtttca tcaattattg ctgtgttaat ggctgtagct 1761901 gtgatggtgg tcagaataaa gtcctctgac aagcctgttt caccaaaaaa aatcattctt 1761961 ccgccgattt ttatgagtac gggagcgtta atgtttttat ttccggtatt ttgggtaact 1762021 ggagcagagt ttttggaagc attcacttta ggtgtgattt tctctatttt tctaatcaaa 1762081 acttctaagt tcgaaattaa aaataatgaa atttacatga aacgctctaa agcatttgtt 1762141 tttatattag tcggtctttt ggtgatcaga atcgtgatga aatcgatctt gagcacatca 1762201 attgattatg gtgcactgag cggaatgttt tggattctgg ctttcggtat gattgtgcct 1762261 tggagaatcg ccatgtattt atcatatcga aaacttcata acgagctgca gtcatctaat 1762321 attcaaatga attaaaaaac ctttcctctt gtcaggaaag gttttttatt tgagaagggt 1762381 ctgataaggt tccaaatcga tttttttgtc ccgcagatgc ctttttaaga aggtatggtc 1762441 tcttttagga gttgcgagaa tatagccttt gatcataagt tgctgatcaa tctttgctac 1762501 cttttctttt aatgcaagct caccgatttt gcctgcgatt ttagcttttg ctgcatctct 1762561 gaacagctct ggcacgggcg cagtcaattc atctagaaac tgtttgtttt catcgttcca 1762621 taaatgtctg ctgttttcaa tatagtaatc ctgccaatca agctctgatc tgccgtcctc 1762681 ttttggtaaa cgctttaaaa actttcgaaa catgaaaaaa ccgccgattg ataataagac 1762741 taccatcatg attacccaaa acagaataaa ccataaaaac catccttcca gcatcaatca 1762801 ttccccctta ttctaaccat attgtatacg aagagagatt agaagaacac agtaaaaaaa 1762861 gaatagaaaa aagtgataga cgtctagtca aaagagatag tagatcatat tctattgtat 1762921 agtgaatctg ctatttggcc atgggagagt cactagaggg tatttgacga taaatggacg 1762981 gaaaaaaagt cactttcata ataggggatg aaagtgactt tttatgttta gctgagagga 1763041 aattgaagag aaaaagaaga gccatcttct gtttctttat tgacggcgac tgtgagtatt 1763101 tgattttcgc attcgacttg aatgtttttg tcattaaaat aaaaaggaag catcatttgt 1763161 ttttcaaaag tctgtcctga cgatttgaca gttaagatga actcgcatcc agaaagggta 1763221 actgttactt gtgtaggctg taaaaaagtc agatccgctt ctataatata ctgctgactt 1763281 gtttcatata aatcaatagg caatgtttcg tcgtaccagg cgaaggggtc ttcaaaaaat 1763341 tgccgaagcc attcatccat actatcgaaa tcattcgcat cgttgcgttt tgaatggttc 1763401 atggaagcat tcctccacat atcaaccttg ctttacatca tatgcggtgg attataaatg 1763461 ggtgaacgca taaaaaaaca gacactaagg tctgcttttc ttacatatca tggcttgagt 1763521 tgtgcttttg tcttgtatgg tttcggtttt ttactttttt gcttccgctt agaggctcgg 1763581 gttggccggg attgtgtcct ttaggggcgt ttttatgcat atctttactt gtattcttat 1763641 tggtcataaa atgagaacct ccttaaaaga gttcggtgtt attgattggt ttttcttttt 1763701 ttgttatttt ggcgttctgc ttcagtcagt acaagctggt cgttttcaat atagccggcg 1763761 cctttgcctt ggctttttgc gtcattcatt ccgttaatga cgtgattcgc ttttcttttg 1763821 accatcatta tcacctcaat cataatatgg cttcttttat tgtgttatat gagagagcgt 1763881 aaacagtaaa aattaccggt acatttttct cataagtcga acttattgta tttaataaaa 1763941 acattgatat ttacttatgt atgattttgt tttaatatga aattgtgaga aaattgtgat 1764001 ggaatgtaat gttcatctga gaatgatctg atctgaaggg ggattttgga gaatggcaaa 1764061 cgagcaaaaa actgcagcaa aagacgtttt ccaagcgaga aaaacgttta ctacaaatgg 1764121 gaaaacatat cattactact ctttaaaagc gttagaagat tcaggtatag gaaaggtttc 1764181 gaagcttcct tattccatca aagttctttt agaatcagta ttgcgtcaag ttgacggctt 1764241 cgttatcaaa aaagaacacg tggaaaattt ggcaaaatgg ggaactgccg aattaaagga 1764301 tatcgacgtt ccgttcaaac cgtctcgtgt tattttacaa gacttcacag gggttccggc 1764361 agtagtagat ctggcttcac tgcgtaaagc aatggcagct gtcggcggag atcctgataa 1764421 aatcaaccct gaaattcctg ttgatctcgt tatcgatcac tctgtacagg tagataaagc 1764481 gggtacagaa gatgcattag cagtaaatat ggacttggaa ttcgaaagaa atgcagagcg 1764541 ctacaaattt ttaagctggg caaagaaagc gtttaacaat tatcaggcag taccgcctgc 1764601 aacaggtatt gtgcaccagg tcaaccttga gttcttggca agtgttgtcc atgccattga 1764661 agaagacggc gagcttgtaa cgtatcctga tacgcttgtc ggaacagact cacacacaac 1764721 aatgattaac ggtatcggtg ttctcggctg gggtgtcggt ggaattgaag ctgaagcggg 1764781 aatgcttgga cagccttctt acttcccagt tccagaggta atcggcgcga aacttgtcgg 1764841 caagcttcca aacggaacaa cagctactga cttggcgtta aaagtaacac aagtgctgcg 1764901 tgaaaaaggc gttgtcggta aatttgttga attcttcgga ccgggaattg ctgaactgcc 1764961 gcttgcagat cgcgcaacaa ttgcgaatat ggctccggaa tacggtgcta catgcggatt 1765021 cttcccagta gatgaagaag cgcttaacta cctgcgcctg actggccgtg atcctgaaca 1765081 tattgatgtt gttgaagcat actgcagaag caatggcttg ttctacactc cagatgcgga 1765141 agaccctcaa tttactgatg tggttgaaat tgacctgtct caaattgaag caaacttatc 1765201 gggtccaaag cgtcctcagg atttgatccc gctatctgct atgcaggaaa cgtttaaaaa 1765261 gcaattagtc agccctgcag gtaaccaagg attcggttta aatgctgagg aagaaaataa 1765321 agaaattaag tttaaactcc ttaacggcga agaaacagtt atgaaaacgg gtgcgatcgc 1765381 cattgctgcg attacaagct gtacaaatac atcaaaccca tacgtgctga tcggcgccgg 1765441 actggtagcg aaaaaagcgg ttgagttagg gcttaaggtg cctaattacg tgaaaacgtc 1765501 acttgcaccg ggttctaaag ttgttacagg atatcttgtg aattcaggcc ttcttccata 1765561 catgaaagag cttggcttta acctcgttgg gtacggctgt acaacatgta tcgggaactc 1765621 aggtccgctt tcaccggaaa tcgaagaagc ggttgcgaaa aatgatcttc tgattacgtc 1765681 tgtcctttcc ggaaaccgta actttgaagg acgtattcac ccgcttgtta aaggcaacta 1765741 tcttgcttca ccgccgcttg ttgtggcata tgcgctggct ggaacggtaa acattaactt 1765801 aaaaaccgat ccaatcggtg tgggcaagga tggtcaaaac gtatacttta atgatatttg 1765861 gccgtcaatg gacgaaatca atgcacttgt taagcaaact gttacgccag agctattccg 1765921 caaagagtat gaaacagtat ttgatgacaa caagcgctgg aacgaaattg aaacaacaga 1765981 tgaagcttta tataaatggg ataacgattc aacttacatc caaaacccac cattctttga 1766041 agagatgtct gttgagccag gcaaggttga gccattaaaa ggactgcgtg ttgtcggtaa 1766101 attcggcgat tcagtcacaa ctgaccatat ttctcctgcg ggggcaatcg gaaaagatac 1766161 gcctgccgga aagtatttgc aagaaaaagg tgtttcacct cgtgacttta actcctacgg 1766221 ctcccgccgt ggaaaccatg aagtcatgat gagaggaaca tttgccaaca ttcgcatcaa 1766281 aaaccaaatc gcaccgggta cagaaggcgg atttacgacg tactggccga ctggtgaagt 1766341 aacatccatc tatgatgcat gcatgaaata caaagaagat aaaaccggtc ttgtcgtatt 1766401 agcaggaaaa gactatggta tgggatcttc acgtgactgg gctgcaaaag gaacaaacct 1766461 tctcggcatc agaacggtca ttgcagagag cttcgaaaga attcacagaa gcaatcttgt 1766521 attcatgggt gtgctgccgc ttcagtttaa acaaggtgaa aatgcggata cactcggctt 1766581 aacgggtaaa gaagtcatcg aggtagatgt tgatgaaaca gttcgtcctc gtgaccttgt 1766641 gactgtaaga gcaatcaatg aagacggcaa tgtaacaact tttgaagcag tcgtccgctt 1766701 tgatagtgaa gttgaaattg attactaccg ccatggcggc atccttcaaa tggtgcttcg 1766761 tgaaaaaatg aagcagtcct gatgaatcaa taggaagaga aggcatttcg ctttctcttc 1766821 tttttatgac acaatgtgct gcggaggtgg catatgctga aaaaatggct cgcagggatc 1766881 ctgcttatca tgctagtcgg ttatacggga tggaatttat atcaaacata cagcaaaaaa 1766941 gaagtcggaa ttcaagaggg gcaacaagca cctgattttt ctttgaaaac gctatcagga 1767001 gagaaaagct ctttacagga tgcaaaaggc aaaaaagtgc tgctcaattt ttgggcaact 1767061 tggtgtaagc cgtgccgtca ggaaatgcct gcgatggaaa agctgcaaaa agagtacgcc 1767121 gacaaacttg cggttgttgc ggtaaatttc acttcagctg agaaaagtga gaaacaggtc 1767181 cgagcgtttg ctgatactta tgacttaacg ttccccattc tgattgataa aaaagggatc 1767241 aatgctgact ataacgtgat gtcatatcca acgacatata tcttagatga aaaaggtgtt 1767301 atccaagaca tacatgttgg caccatgaca aaaaaagaaa tggaacaaaa actggatctt 1767361 gattagattc agtttttttt atactcaaat atgcttacaa gttttcagaa ttggaaaaaa 1767421 taaaagaata tgcggaggtg agaagcgtga agaagatgag aaaacgttct tttcatgagc 1767481 tcgtcatgga aaacaaaaaa gagctgatga ccaatacaga gtatttaaat cagcttgagg 1767541 aaaagcttga acagcgattt aagcaaaaat aacctttaat ttgtattcat gtttacccct 1767601 ccttttgaga aacctatctg ttgaggaggg ataaacatgg gaaacaacaa gaaaaacggt 1767661 cagcctcaat atgctccaag ccacttgggt acaaagcctg taaaatataa agccaataaa 1767721 ggggaaaaaa tgcatgatac ttcaggacag cggccgatta tcatgcagac aaaaggcgag 1767781 tagcgaaaat tcgagtttat ttctaggagg tacatccgaa tgacaaagaa ccaaaatcaa 1767841 tatcagcagc ctaatcctga tgatcgttct gacaatgtgg aaaaattgca ggatatggtt 1767901 caaaatacaa ttgaaaatat agaagaagca gaagcatcaa tggagtttgc ttcaggagaa 1767961 gataaacagc gtatcaaaga aaaaaatgca aggcgcgaac agagcattga agcgtttcgt 1768021 aatgaaatac aggacgaatc tgcagcgaga caaaacggat accgttctta aaaaaccagg 1768081 gaaacctggt ttttttcttt ctgatttgat tatggtaaaa tggggctaaa ttgacgttaa 1768141 gggagcagag taatcttgca tgtatcaaaa aaagaaatag aagtgcgtta tgcagaaaca 1768201 gatcaaatgg ggattgtcta tcacgcaaat tatcttgtgt ggatggaggt cggcagaacg 1768261 gccttgatta aggacttagg ctttttatat agtgatatgg aaaaaaaagg cgttctgtcc 1768321 ccagtcgttg atatcaatat ttcctataaa aagccgcttc attacggaga aaccgcggtt 1768381 gtacatacat ggatagagga ctataacgga tttaaaaccg tctatggtta ccacatttat 1768441 aatccggccg gtgagctttc catcaaagcc acctcatctc atatttgtgt ggataaagaa 1768501 agctttaagc caattcaatt ccgcaaagct tttcctgatt ggcacacagc atatgaaaag 1768561 gccaaaaaat agggaagtga acgggatatg gcgtttggtg tgaaacggga ggaacttaac 1768621 cggtggaaac aagcagtgaa aagaggagaa atcgcatttt taacacatta ctggctggat 1768681 gaccgatttc cagaagcaaa gaccgtgaca aaagccggct gtgcagacat tgataagctg 1768741 gttcagtggg gagcggcgta cgggttaaaa aaagaatgga tccataagaa aagtgaattt 1768801 ccccactttg atctgctggg ggaaacacaa aaatatattt tggaacaaga aaacctaacc 1768861 gatcatctta tacgatttca tttgtaaaaa aagaacgcac atgaagtgcg ttctttttta 1768921 ttggtattca aaaaccggtt catcagcgtc ttctgaatag ctgacgagaa ggtcgtggtt 1768981 atcaaagtac cataaatcac tttcttcaat aaagaaggta atgccatcag cttctgcagt 1769041 gactccagcc tcttgtgggg catctttcgc tacaccgaga gaaaaaccct tttgaacgtt 1769101 gctgcagcct ccatagcgga cgaaaaagcg aacctggtct ccgctttcca aatcgagttc 1769161 ttctttatac cagttcaatg cgtcttcgtt aattgtcata ttcataacag aacacccctt 1769221 tgttcttcat ttgaattttc tctattataa acgtattagg ctattctgtg tcaaaagaga 1769281 agttttttaa gcttataacc attttacttt aggttctgtt ttattgataa ttcgtttaat 1769341 gttcgctcgg tgtctgtata tcacaaaaat agtgagcagg gtaacgacaa tcaataaata 1769401 cgtatcatgg acaaagaaac tatatataac agtatagatc cctgttaaca tcgatgagag 1769461 agaaacaaat ttagtcaagt ataaaaagat gaagaatacc gcaaccatcg tgataaataa 1769521 caggggtgcg taaaatagca aaacgcctcc tgatgtcgcc acggctttac cgcctttaaa 1769581 tttggcgaag atgggaaaca cgtggcctaa aaccgcaaag actcctgcaa gaagcgggtg 1769641 aatatcaaca tgcatgagaa aaggcaatgc agttgccagt gtccctttca aaatatctcc 1769701 ggctatgacg accgaaccag cttttacacc caatgtacgg aatgcattgg tagcgcctaa 1769761 gttgccgctt ccgtgctccc gaatatcaat tcctttggca agcttgccca caattaagcc 1769821 agatggaatg ctgcctatca agtaggccaa aataatcaat aaagcaatta acatctacat 1769881 ttctcctttt tcaaattccc ttctttttat tttaacatga gatgtcatga tctgatgata 1769941 agtttttttg taaagtttgc ttacaaatca aatcaaacat gcatcatatt ttgatttctc 1770001 ctgttttgat cgtgtaaaat aagtgaaaaa ggagtgacac acgatgcaaa acccttctaa 1770061 agcggaaatt aaagagattc ttcaaagaag caaacgtata gcggtagtag ggctttcaga 1770121 ccgtccggat agaacgtcac atatggtttc aaaagcaatg caggacgcgg gttatgaaat 1770181 tatccctgtg aaccctacaa ttgatgaggc gctaggtgtc aaagccgttt catctttaaa 1770241 agagatagac ggtccgattg acatcgtaaa tgtattccgg cgctcagaac agcttcctgg 1770301 agtggcggaa gagtttttag agacagatgc gccagtattt tgggcacagc aagggctagt 1770361 taatgaggaa gcataccaga tgctaaaaga aaaaggcaga acggttatca tggatctgtg 1770421 cataaaagtg gcacacgctg taacaaaata ggtgcagaac tgcaaaaatc cttgtaaatt 1770481 caaggatttt tgctttttaa ttttaagata ttgtttgcgt attacggtga aacagataca 1770541 ataaagcttg aacagctttt tttgaatacc ttgtccagct gggtttcggc cgttcgattt 1770601 gcgaaggtct gctgctttat atataataaa caaacatacg ttctcatagt gtaaaaacag 1770661 cactagccga tgttttgaga agaactgatt cgttagctct atgttgcgat tgcaaacata 1770721 ttggttataa tgaggagtcc aaggcagtac tggctcgagg cgaggtttat aaaaaatatc 1770781 ttatatacaa atgatgtgta acactgaaaa gagaaagaca atgttagttt ttgaaagggg 1770841 tttgtacgtt tggctagaaa acagcaattt gattacaacg aagatgccat acaggtgctc 1770901 gaaggccttg aggctgtcag gaaaaggccg ggtatgtata ttggctctac tgacgcgcgg 1770961 ggtttgcacc acttggttta tgaaattgta gataactctg tcgacgaggt gcttgccggc 1771021 catggagatc acataatcgt caaaatacat aaagacaata gtatttctgt acaggataga 1771081 ggccgcggca tgccgaccgg aatgcataag ctcggcaaac caacccctga agtgatttta 1771141 acggtgcttc atgccggagg gaaattcggc caaggcggct ataagacaag cggcgggctc 1771201 cacggagttg gtgcatcagt cgtgaatgct ttatctgaat ggctgacggt taccattgag 1771261 cgggacggtt ttgtctatca gcagcgattt gaaaatggag gaaaaccggt tacatctctc 1771321 gaaaagatcg gcaaaacaaa aaagacggga actcttacac actttaagcc agatccaacg 1771381 atgttcagca caaccactta taattttgaa acgctctctg agcgcttaag agagtctgcg 1771441 tttttgttaa aaggactgaa aattgagctg attgatgaac gcaatgacca gcgtgaggtc 1771501 ttttattatg aaaacggcat agaagcgttt gttgcttact taaatgaaga aaaagacgtc 1771561 ttgtctgaag tggtctcgtt tgagggtgag catcattcta tagaagtgga ctttgcgttc 1771621 cagtttaacg atggttattc tgaaaatatt ttgtcgtttg tcaacaatgt cagaacaaaa 1771681 gacggcggga cgcatgagtc aggtgcaaaa actgcgatga cgcgtgcttt taatgaatat 1771741 gcgcgaaaag tggctttgct gaaagaaaag gataagaacc ttgaaggcac cgatataagg 1771801 gaagggcttt cagccattat ttctgtccgc attcctgagg agcttcttca atttgaggga 1771861 caaacaaaag gaaagctcgg taccagtgaa gcaagatcag cggtggatgc gattgtttca 1771921 gagcagcttg cttacttttt agaggaaaat cgggacaccg caacgcttct tgtcaaaaaa 1771981 gcaatcaagg cgagccaggc gcgcgaagcg gcacgcaaag cccgtgaaga agcaagaagc 1772041 ggcaaaaaac gaaaaaaatc agaagcgact ttaagcggaa agctgacgcc tgcgggttca 1772101 agaaacccgg caaaaaatga attgtatctc gttgagggag attcagcagg cgggtcagcc 1772161 aagcagggac gagaccgcag attccaggcg gttctgcctt tacgcggtaa agtcattaat 1772221 acagaaaaag ctaagcttgc tgatatcttt aaaaatgaag agatcaatac gatcattcat 1772281 gcgatcggcg ggggagtcgg ggcagatttc tcaatcgatg acatcaacta cgacaaaatc 1772341 atcattatga ccgatgccga tactgacggc gcccatattc aagtgctgct tcttaccttt 1772401 ttctatcgct atatgaaacc gctcattgag catggcaagg tgttcattgc gctgccacct 1772461 ttatataagg tcagtaaagg aagcgggaaa aaggaaatca ttgaatatgc atggtctgat 1772521 gaagagatgg gggatgtcct gaaaaaagtc ggcaaaggct ataccattca acgatataag 1772581 ggtcttggag agatgaacgc agaccagctg tgggaaacga cgatgaatcc ggagtcccgc 1772641 acacttgtta gggtcaaaat tgacgatgcg gcacgtgtag agagacgtgt gacgacgtta 1772701 atgggagaca aagtagagcc gcgcagaaag tggattgaga aaaacgtcgc tttcggctta 1772761 gatgaagaaa gcaatatttt agaaaatgaa aacttatcgg tcgctgagga ggtttaatga 1772821 ttgtcacagc cagaattatt tcatgattta ccattagaag aggtgatcgg cgaccgtttt 1772881 ggacgctaca gtaaatatat tattcaagac agggcgctgc ccgatgcgag agacggatta 1772941 aagccggtac agcgcagaat tctgtatgca atgcatacag atggaaacac gtttgataaa 1773001 aacttcagaa aagcggccaa aacggtcggt aacgtcatcg gtaactatca tccgcacggt 1773061 gacagctcgg tttatgaagc aatggtgcgg atgagccagg attggaaagt tcgtaatgtg 1773121 ttaatcgaaa tgcatggaaa caatggaagc atcgacggag atcccccggc agccatgcgt 1773181 tatacagagg cacgattatc tccgatagca tctgagcttc ttcgggatat tgacaaaaac 1773241 acggttgaat ttgtgccgaa cttcgatgat acaagcaagg agcctgtcgt actcccggcg 1773301 atgtttccta acctattggt caacggatct accgggattt cagcaggata cgcgaccgac 1773361 attccccctc atcatctggg agaagtcatt gatgctgtca ttaagcgtat tcaaatgcct 1773421 tcttgctctg ttgacgaact catggaagtt attaaagggc ctgattttcc gacaggcggt 1773481 attattcagg gcgttgacgg gataagaaaa gcttacgaaa ccggaaaagg aaaaatcatt 1773541 atccgcggaa aggctgaaat tgaaacaatc agaggcggac gagaacaaat tgtcattact 1773601 gaaattccat ttgaagtaaa taaagcaaac cttgtaaaaa aaatggacga gttccgtatt 1773661 gataaaaagg ttgaaggcat ctcagaggtt cgtgatgaaa cggatcgaac agggctgaga 1773721 gtggtcattg aactgaaaaa agaagctgat gccaaaggca ttttgaattt cttatataaa 1773781 aatactgatt tgcagatcac atataacttc aatatggtgg ctatccataa ccgccgtccg 1773841 atgctgatga gcctgccgtc tattttggat gcatatatcg gacaccaaaa ggaagttgtc 1773901 acaaaccggt ccgtttacga gcttcaaaaa gcaaaagaca gacatcatat cgtagaaggg 1773961 ctcatgaaag ctttgtctat tttggatgaa gtgattgcaa caatccgttc ttctagcgat 1774021 aaacgtgacg ctaaaaacaa tttgatcgcg aaatatgaat ttacagagcc tcaggctgaa 1774081 gccatcgtgt cattgcagct atatcgttta accaataccg atatcacagc gcttaaggaa 1774141 gaggcagaag agctcggtaa aaaaattgaa gagctcgaat ctattctgag caatgataaa 1774201 aaactgctaa aagtgattac aaacagctta aaagcactga aaaagaaata tgcagatacg 1774261 agacgctccg tgattgaaga aaaaattgaa gaaattaaaa tcaatctcga agtcatggtt 1774321 gcatctgagg atgtatatgt aaccgttacg aaggatggtt acctaaaacg gacgagccag 1774381 cgctcatttg ccgcttccaa cggtcaggac ttcggaatga aagatacgga caggatgctg 1774441 catcagtttg aaatgaatac gacagacgtg ctgctgctct ttacgaacaa aggaagctac 1774501 atctattgtc ctgttcacca gctgcctgat atcagatgga aggacatggg ccagcatttt 1774561 tcaaatctaa tcactattga ccgtgatgaa acgattgtaa aggctatacc gataaaagaa 1774621 tttgatccgt cggcatatct tctattcttt acgaaaaacg gtatggtgaa aaagacagag 1774681 ctcactcatt ataaagcaca gcgttattct aaggcacttg tagccttaaa tctgaagggt 1774741 gaagatgaac tgattgatgt acatgtaaca aatggggaaa gccagatctt tatggccact 1774801 cacttagggt atggtctatg gtttggagaa gacgaagtga atgtagttgg cgcgcgtgcg 1774861 gcaggtgtca aagggattaa cttaaaagag gatgactttg ttgtctccgg tgagattctt 1774921 cagcaatctg attcaattgt cttgttcaca cagcggggag cggttaaacg catgagtctt 1774981 tctgagttcg agaagacatc ccgtgcaaaa cgcggtgtcg taatgctaag ggaactgaaa 1775041 aagaatcctc accgtgttgt agcactgttc gcttgcggtc ttgaacagcg actaatggca 1775101 gaaacagaaa aaggcgacag aaaagaactg cagacaaaag agttgcggac aaacgacaga 1775161 tacagcaatg gctctttctt ttttgatgaa gaggaatcag gcaaggttac agctgtttgg 1775221 cgccttcata cagaacaata ataaaaaacc cgctcatact atatgagcgg gtttcgtttg 1775281 ttttttatca gctttcatgg ttggtgaata gatctgttac agcatgaatg acttcaatcc 1775341 cctgccatac aaataaattc agcgctgtga aagaaaataa gcctaaaatc accattctta 1775401 agataaacaa catgtttaac agcctcctca tattttcgtt acataatcgg gtgatgttga 1775461 acatgaagtt tgccgaaata agacgattga taaaatttgg ccagtataaa gctttttttc 1775521 cgctgacgtc tgcgggagta tcccgtactt ttgctttcag cggtcagcag cagaacagcc 1775581 attgcccata aagcggtcag cgtaaatgcc cctgtgatgg atttcttctc atcatcagca 1775641 ttttggccgg ctttcatctc atgcatttcc tgctggtcgg ctacggcttt ataatgatgg 1775701 ccgatatcaa aggcgtgggg aattgagaac aaatgaaaac tggcaatcgc caagaataag 1775761 atggatgctt tcaatatcgt tacttttttc aaatgatctc cccctccttt aatattactg 1775821 aatattttta taataatacc ccaatccatc ctaaaagtaa acctgattta ttaaatttaa 1775881 aaataaattt aactttgtta agtatatatc tttttgctta tttttgaaag agaaaacttc 1775941 ttttattagc gtatgtatac ccggtttatg gtgtgaataa aaacatattt taaatgatat 1776001 gttgtttagg atttattact ttatttatgt gtaaatcaaa gagaaaggca agagaatggg 1776061 aagaaatgat tacattgtta atagggtact ctttttttaa agccagtttg caaggaatgt 1776121 ttttattcgt aggaaaataa tagagaaggg gtcgacagag taacatctgg ctatgacaat 1776181 attcttctcg aaaaaacttc ctaattcgtc atattgtgat ataataaaac tcgttatgtt 1776241 aaaaaatcta acatcaaaat cgaattcgta ttgaattgat gaaaacggga ggtaaatatg 1776301 gagtcttttt tcaatagttt gattaatatt ccaagtgatt tcatctggaa atacctattt 1776361 tatattttaa tagggcttgg attatttttt accatacgtt ttggttttat ccaattccgt 1776421 tattttattg aaatgttcag aatagtaggg gagaagccgg aaggaaataa aggtgtttca 1776481 tctatgcagg cattctttat ttcggccgca tcccgagtcg gcacagggaa tttgactggt 1776541 gtagccttag caattgcgac aggcggacca ggcgctgtat tttggatgtg ggtagtggct 1776601 gcagtaggca tggcttcaag ctttgtcgaa agtacattag cacagcttta taaggtaaga 1776661 gacggggagg atttccgcgg agggccggcc tactatattc aaaagggtct tggtgccaga 1776721 tggcttggca tcgtttttgc aatcttaatt accgtctcat tcggcttgat ttttaacgct 1776781 gttcaaacaa atacaattgc tggagcattg gatggcgcat tccatgtaaa taaaatagtt 1776841 gtagccatag ttctggcggt tttaactgcg tttatcattt tcggcggttt aaaacgtgtt 1776901 gtcgctgttt cacagctaat tgtgccggtt atggcaggca tttatattct tatcgcttta 1776961 tttgttgtca tcacgaatat tacggctttc cctggcgtta tcgctacaat tgttaaaaat 1777021 gctttaggtt ttgaacaagt cgtcggcggc ggaataggcg gcatcatcgt tatcggtgcg 1777081 caacgcggac ttttttcaaa cgaagcagga atggggagcg caccaaacgc ggctgcgacg 1777141 gctcatgtat cccatccggc aaagcaaggc tttattcaaa cattaggcgt atttttcgat 1777201 acatttatca tatgtacgtc cacagcattt attattttgc tgtacagtgt aacgccaaaa 1777261 ggcgacggca tccaagtcac acaggctgct cttaaccatc acattggagg ctgggcgccg 1777321 actttcatcg cagtcgcaat gttcttgttt gcattcagtt cagttgtcgg caactattat 1777381 tatggcgaga caaacattga atttattaaa acaagcaaaa catggctgaa catttaccgt 1777441 atcgctgtta ttgctatggt tgtgtatgga tctttatcag gcttccaaat cgtttgggat 1777501 atggcggacc tctttatggg tatcatggcg ctgatcaact taattgtgat tgcgctgctg 1777561 tcaaacgttg cttacaaagt gtataaagat tacgcgaaac agcgtaagca aggacttgat 1777621 cctgtgttta aagcgaaaaa catcccaggg ctgaaaaacg ctgaaacatg ggaagatgag 1777681 aaacaagaag cataatataa atataaaaca aagctgcatt caatagttga atgcagcttt 1777741 ttcattattg gaaataaatt taatttttcg actcgaatga aaaatgacgt gtaaagtccc 1777801 aattcagtcc agttttcttt gttctatatg tgtcatgtgt gtcttattca ttggaggtag 1777861 agcaaattga caggctttta aacctcccca aaacaagaaa ttaggttgat agacaatcat 1777921 gagaaagatt tttacaatga gttcgtgctc ataagaagtg tagagccaaa atgatgcgaa 1777981 ggaggaaaag atcagatatg aaacggtcaa tctctatttt tattacgtgt ttattgatta 1778041 cgttattgac aatgggcggc atgatagctt cgccggcatc agcagcaggg acaaaaacgc 1778101 cagtagccaa gaatggccag cttagcataa aaggtacaca gctcgttaac cgagacggta 1778161 aagcggtaca gctgaagggg atcagttcac acggattgca atggtatgga gaatatgtca 1778221 ataaagacag cttaaaatgg ctgagagatg attggggtat caccgttttc cgtgcagcga 1778281 tgtatacggc agatggcggt tatattgaca acccgtccgt gaaaaataaa gtaaaagaag 1778341 cggttgaagc ggcaaaagag cttgggatat atgtcatcat tgactggcat atcttaaatg 1778401 acggtaatcc aaaccaaaat aaagagaagg caaaagaatt cttcaaggaa atgtcaagcc 1778461 tttacggaaa cacgccaaac gtcatttatg aaattgcaaa cgaaccaaac ggtgatgtga 1778521 actggaagcg tgatattaaa ccatatgcgg aagaagtgat ttcagttatc cgcaaaaatg 1778581 atccagacaa catcatcatt gtcggaaccg gtacatggag ccaggatgtg aatgatgctg 1778641 ccgatgacca gctaaaagat gcaaacgtta tgtacgcact tcatttttat gccggcacac 1778701 acggccaatt tttacgggat aaagcaaact atgcactcag caaaggagca cctatttttg 1778761 tgacagagtg gggaacaagc gacgcgtctg gcaatggcgg tgtattcctt gatcaatcga 1778821 gggaatggct gaaatatctc gacagcaaga ccattagctg ggtgaactgg aatctttctg 1778881 ataagcagga atcatcctca gctttaaagc cgggggcatc taaaacaggc ggctggcggt 1778941 tgtcagattt atctgcttca ggaacattcg ttagagaaaa cattctcggc accaaagatt 1779001 cgacgaagga cattcctgaa acgccatcaa aagataaacc cacacaggaa aatggtattt 1779061 ctgtacagta cagagcaggg gatgggagta tgaacagcaa ccaaatccgt ccgcagcttc 1779121 aaataaaaaa taacggcaat accacggttg atttaaaaga tgtcactgcc cgttactggt 1779181 ataaagcgaa aaacaaaggc caaaactttg actgtgacta cgcgcagatt ggatgcggca 1779241 atgtgacaca caagtttgtg acgttgcata aaccaaagca aggtgcagat acctatctgg 1779301 aacttggatt taaaaacgga acgttggcac cgggagcaag cacagggaat attcagctcc 1779361 gtcttcacaa tgatgactgg agcaattatg cacaaagcgg cgattattcc tttttcaaat 1779421 caaatacgtt taaaacaacg aaaaaaatca cattatatga tcaaggaaaa ctgatttggg 1779481 gaacagaacc aaattagtta agcttttttt tggcggacat cagtaacgat gtccgttttt 1779541 atcatctaat aggaggtttg cgttgtggat gaaatactga aacagtatat ggtgctgtat 1779601 aaaaaaatga gtaatatgat aaatggtccc gactatccag gtaaggaaaa agacatccag 1779661 catcaaaaag atcagatcga agtttacgaa aaacagctgc agcaaggatt ttctacagat 1779721 tatgactatg atgtgtttgc tgattctgtt atcaaatgcg catatggcga tatgacgctg 1779781 gaagatttag aagccgttta ttatggattg acaacaccat ttttttgatt tgtcattcag 1779841 cagtaaaatt tcaatttctg tctcactaac ttaagtatac tttgatattg agacagaaat 1779901 ttatttattt tgtttacttc ctagaatata tattatgtaa actagaaaag atgaagaata 1779961 aagctttgct gtttttatgt acatcctttc ttcttcctgt aattcagcaa caaaataaaa 1780021 aagcgatttc ccaatcggaa aatcgccaat tcagacactc tattatttat gtgtgtcttt 1780081 gtgctcttaa cgatttacaa caaatgttgt cacgctttga gctggaagat gagcccaaaa 1780141 atgattgcct gatacagtga gattcgttcc aggttgtaga ttgctgctgc tgctcgtgat 1780201 ccatctagat acgtttgaag cagatccatt ctgcaaaaca aagttttggt tgactcctgt 1780261 gttgctttta ttgatggcaa caataacgac cttgttgtca cctttatagg ctgacacgta 1780321 aacgttcgca ttagggtttt tcgttgcatc aatccttaca tagccgggac gcacaaactt 1780381 tgagaaatga gccatattgt agccgcgttt gctgatcgta ccatcttctt tcataggtcc 1780441 atatgatctt cggatgtacc accatacata agcttgaaag tccccctcta ccatcgcatt 1780501 gtgaatatgc tgtgaaacat ccaatgcctc aggccatcga tccgccgagt tggtatcact 1780561 gtttggatag tatacttccg tcatccaaag gtccttcccc gctccttttt gtttgaaaag 1780621 aggataaggg aattggctga cctgggtgcc gtacaggtga gttccgagaa tatccatatt 1780681 ggcaagagcc tgcggatcgt tcaagatcgg gtccgacaaa ttcttcaagt attgaaatga 1780741 ctcaggcgca atgacgcggg cattgatcga gccggcgttt tctctcataa agcgaagtat 1780801 ttcttgcggc gtccaccacg tccactcgtg agcgtaatca ggctcgtttt ggaccgaaat 1780861 cgcgtaaaga ttcacaccat tattcttcat gaaggtaaca aaatcgttaa gatgctgcgc 1780921 gtatgctgcg tacttgttgt atttcagccg tttagccgat gtgtcaccat tccgattaaa 1780981 ggtctcaacc atatcacttg gaggattcca aggagaagca aaaacgattg ctccgtgttt 1781041 gaccgcactc tttgcagtct ccacctcttt ataccaatta tttcgatttt catctacatg 1781101 aattcttaag attgaaaatc ctaactggtt ctgtccattg ccaaaagcag tttctctttg 1781161 agctgctgta agatccccag cccaagccgg atgattcatc cctccaaaac cgcgaatcac 1781221 ttgtttctct gcagatacat taactgttac atcacttgct gccaaaactt cagtagcgcc 1781281 tggccctaac atgactgaca gcatagtgaa acatactaat agtacacaaa ttgttttttt 1781341 tatgcgtgga atcatttatt cctctccttc gtcatgtgtc ttttacggta ttaaaaaatc 1781401 tgcatggcat atccataatg gcgggctgtt ccggtgctgg cccgtacttc acccgcctcg 1781461 tttttaagcg gtcccattac gagtactatc tttgcgtaaa ctgccagtaa tcaaaattaa 1781521 acaagtttcc tgtacctgtt ccggtaaata caaagaatac tttgtgcaca ccggttgccc 1781581 cgcttaccgc agtttctatt tccctccacg tttgcgctcc gcctgttgaa ggcacattca 1781641 gagttccaac aagcttaccg tctgcactgt cgaggcgcac ttctattttc ccgcctaaag 1781701 tggatgctac atttgcttta aatgacctgg caccgcccgc tccgaagtct gcatttccta 1781761 cagcaatcca gtctccattt tgaatgcttg ttacatgctg attatttact ggcccgccgg 1781821 gtgctgtgga cttctctgtc aaaatgcgtc cattccaagc aaacgtttca gcttctaccc 1781881 ggttatatgg gtttaaattg gaaatttgtg ttacacctgc ataatttgcc gctacctctt 1781941 gaatagatcc atctgcatta tgcaccagct tattaatatg gggagagcgg tatcctttgc 1782001 cggccccgaa cagagcggaa ctgacagttt gcgcatggta caccacatac cactcgtttt 1782061 taaaattgaa aacagcatga tggttgtttc cgccacctcc gaaaaatgca cccggatttt 1782121 tcaggaagtg ccctctatat gtaaagggac ccatgggact tgaactggtc atgtagccga 1782181 tctcacccgg gggtttatcg gccgggtgcg tgccgccgaa attgatgcaa taggagtaat 1782241 aatatgttcc gttatacttg tgcaatcccg aatcttcaaa catgaaaggc gcatcaattg 1782301 tagatgcact tccaacaaca ctcgtcatat caggccccaa ttttatgact ctagccgttt 1782361 taggattggc ccattgtccc tgcgttggat ttgaaacgcc aggaacgcct ccgccggcat 1782421 acaggtaacc ggttccgtcg tcatctacaa atactgccgg atcaaaaagc catacaacac 1782481 cagacattcc tggcgtactt ggcgttacga gcggttttcc gattgggtcg gtccatggac 1782541 caatcgggct gtctgcggtg agaaccccga tacctccgcc gctgtttgcg aaataaagga 1782601 agaatttatc cttgccatta atttttttaa ctgcgattga cggtgcccat gacgcacctg 1782661 cccattttgc aattccacgg cctccattag ctccattggc acctgctacc ggaatggctc 1782721 cgtggtctgt ccagttcacc atatccgctg aagatatgac gaatactcta ttcaaattgg 1782781 caaatgaatt atctttaatt gttccgttgc tattatattc atagtcatca cttgacatat 1782841 agatgtagac tcttccgtta taggtcagcg caaccggatc cgctcccaaa tgatggtcga 1782901 taagcggatt tgaattccct atatgttttg caattgtagt actagtggca gcatacgcag 1782961 acttcccaga taagcagctc aataataaaa ctagaatcca taaacatacg ctacactttt 1783021 tcctcatcac ttcacatcct cctttttcct taaaatgggg gattttcttt tggaatttga 1783081 taacaacagg tcacgaagat tgcacgcata aagtagccgg aagctgttta gcaatgttcc 1783141 cagttgttct gaaagctcat cttcatgtgt ctccattctc tcttttcttc gaggagatcg 1783201 caccactcct tcaaaattgt tcaaaaaaac ttccccattc ctagcgacca ttgtccagaa 1783261 aataaaaaga caggattgtt catggcctcc cactaatcac attgaacgga gattacatca 1783321 ttatccaaga tatcccttta tctaacatcc tacatcatta aaaaaattgt gtatagaaac 1783381 ttttggagga gttagtgttc gattctacaa aggaactgga tacatttatt cattgataag 1783441 atggggctaa cactccgttt atatttgtat gttttcagac acaaaaaaca gccgttcaat 1783501 gcggctgttt ttttcaagag tataagacta ttgagcggta tacccgcttt ttcatgtttt 1783561 gttcatattt tattaattgt ttattcaaca ctgtccgcta tagtaatcca tatcaacaaa 1783621 tatgactgcc actcgcatct tttatgaagg gaggttcgtt acgctgaaag aaaaaataaa 1783681 gacattaggc cgtttttgca ccgtaggcgt cggcaatacg ctgatagatt ttggtgtctt 1783741 ctttcttctt accgcttgtc atgtctctta tctgccggcg cagatctgct cctatactgc 1783801 aggtatcgtc aacagctatg tgtggaaccg gaattggacg ttttgtgtga aacgtaaggc 1783861 tgacgggaaa gagatcgtgc gttttctcat gattaatatt gccgcgtcag ggatcacctt 1783921 tttgctgctt tatttgtttc aaaattgcgg ctgctcgctt ttggtgagta agctcgccgc 1783981 cactatcggc ggaatgatga tgaattttat cggaaaccga atctgggtat ttggagattc 1784041 gctgaaaaac atacaggatc aggagtgaag atgaatgaga aaaaaagtga gaaaagcggt 1784101 tatacccgca gcgggtttag gaacgagatt tctgccggcg acaaaggcgc agcctaaaga 1784161 aatgcttcca atcgtcgaca aaccagcaat ccaatatatt gtagaagagg ccgcagagtc 1784221 aggaattgaa gatatactga ttattacagg gagaaacaaa cgctcgattg aagatcattt 1784281 tgatcggtcg gcggaattgg aattcaatct ccgggaaaaa ggcaagacgg agacacttaa 1784341 ggaaatgcag cagattgccg atttggccaa cattcattac atccgccaga aagaaccgct 1784401 cggattaggc catgcggtgc tgtgtgcgga gcattttatc ggagatgagc cttttgctgt 1784461 tctcttaggt gatgatatta tggtgtctga aacaccggct cttcggcaat taatggatgt 1784521 atatgacgtt tatggcacag aggttgtcgg tgtacagtca gttctccctg aggatgtcag 1784581 caaatatggt attataaata catcagggtc tcaagggcat gtatatgaag tgaacgattt 1784641 agtggaaaag ccttctcctg aagaagcacc ttcggaaatc gcagtaatgg gacgttatgt 1784701 gctgaattct tcgatcttct ccgttttgaa gacaattggc agaggcgcgg gcaacgaaat 1784761 tcagctgaca gatgcgcttc gtgaggtttg ccgtaaggag ccgatccatg cccggctgct 1784821 ggaaggaaat cgatatgaca ttggcgataa gctgggctgt tttaaagcga gcaccgaaat 1784881 cggcttaatg cgtcccgaaa tgagatctca gcttttggcc tatttagaag atgtgatcaa 1784941 acgggaaacg aaagaaatgc tgcggtaaaa aaattgtaac catcttgctc gtcaatcagt 1785001 catataatag tgaaaaagat taggacaggt tgtgaagaat gtgggcagtt tgataagcga 1785061 aattttaaca tggctgacga acatgggata tgcgggtatt gcgattgggt taatgattga 1785121 aatcattccg agtgagattg tattagctta tggcggctat atggtatcgg agggcacgat 1785181 tggatttatt ggcgcaatta ttgcgggtgt tatcgggggc accattgccc agatctttat 1785241 ttactggatc ggtcgctatg gcggcaggcc atttctggac aaatacggga agtatttatt 1785301 gattaaaaag catcatatcg atatgtcgga aaactggttt cagaaatacg gcgccggagt 1785361 tgtcttctcg gctcgtttta taccggttgt cagacatgcc atatccattc cggcaggtat 1785421 tgccagaatg ccttttctca aatttgtggt actgactgtg cttgctatca ttccatggtc 1785481 tatcctgttt gtttatttag gcatacagct aggaagccag tgggatgatg ttgagaatat 1785541 agcaggcact tatacaacac cgattatgat attggctgtt gtcgtgatag ccctttattt 1785601 tgtgattaag aaacgtacag ccatatttaa acgatagcta gcggatatgc ataggggtga 1785661 ctgacgctcc cctatgcata tttttttact tgcgatgttg atttgccagc ttcagattct 1785721 ccgctaaaaa tgcgacaaac acttcatccc gcacgagcga tgcggcataa tttctcttaa 1785781 taaaccattc tgcctcttca aacgctgcga atgtttcgtc ttgggtttct ccgttaattt 1785841 gaatattcca ttcgttgtct aaagggaaaa gaaaaaatct catttgtgcg cgattttcat 1785901 ataatgatcc attcgcagat ccctttagat tatagatgtt acggaaggca tccggccgta 1785961 caggatcaat acggaaagct tcagctacaa acaactcgta tacttcatcg gttattgaac 1786021 agccggacgc ttttgcatgc cctccgccgc catatcggcc ggcgatttct gacacatcga 1786081 tgtaatcatg aatggtgcgg agactgactc gttttgaccc catgctcaaa atcgcaatgt 1786141 aatcgaggtg cgggttatct ttccctagcc tgttccccag ctctgaatgg tacgattcag 1786201 cgtgaacgat gcctacacag tgttcgtgaa caaaggtttg taccatttcc cttttctttc 1786261 tgcggaggta gcgctcgatt ttttcgtctt ctaaatcaag cagtttttct tcaaaatcat 1786321 cgaagaaaaa ttcgtcatgc gtggaaaggc gctggatcat ttttgcttca aattcatcga 1786381 ttgacagcaa aaagaaaaga tcattaagcc gcttcgcctg tttttgatcg taccgctccc 1786441 actcccatgt atcgtattgg cggacgagct ctgtgaattg atctaaggcg tttgtcggtt 1786501 tcatgaagcc attttcaatg agatagccat ataaaagcga tgtcgcggat gtgagccttc 1786561 catcatcgta ttccacctgg acaaatcccc attcatgctc attcaaatga agggctgttt 1786621 tatgatggtc aatgagcttc actttgcccc ctgcatgaac atactcattc aatctctctt 1786681 cgttttcttc attgacggcg agatcggtga tgaataacgc gtcctgtctg ttgctctcct 1786741 tcgctttttc taaaaagtac tgcacctgtg cgtttaagcc gttgacagag ttataccgga 1786801 tctctacgtc ttttccgaac gccaattttg ctacgattcc gcatcctact ccgtccaagt 1786861 cgttatgtga atataaatga tacataatgt aggccccttt ttatgataaa ctgacaattg 1786921 ccgctagagg tgcggcagcc tttatttact attctaaaaa accaagcgtt ttatgcaatg 1786981 gtaattagtt gacataatgt tgttattgta aatatataaa ggagcgcttt ttttgcgctc 1787041 ctaagttctt gcttttacac cggataaacc ggatgctttc gattggtaaa tgtcatttcc 1787101 tttgtcatgt atgccttgag ccgtttggcc agctcatcac gcagcgaatt ggctgggata 1787161 acagcatcaa tgatcatttc tgaagccaga cggtagatat tgatgtcctc tttgtattcc 1787221 tcccgtttgc tgctgataaa tgcggctctc tcttcttctg gcagctcggc gattttttta 1787281 gcgtagacag cgtttacagc ggcctcaggg cccatgacgg cgatttgggc ggttgggagc 1787341 gctagacagc aatccggttc aaatgccggc cctgccattg catacaaccc cgccccgtaa 1787401 gcttttcgga caatgacaga gagttttgga acagttgcct ccgacatcgc agaaatcatt 1787461 ttcgctccgt gtctgataat cccagcctgt tctacttttg tgccaatcat aaaaccgggg 1787521 atatcggcta agaacagcaa tgggatatga aaagcgtcac ataaggtaat aaacttagcc 1787581 gctttgtctg ctgaatcgtg gaataagacg cctcctttta ccttcggctg gtttgcaaca 1787641 atgccgacag gctgtccgtg gattcgtgcg aggcccgtca ataattccgg tgcaaataag 1787701 gctttgatct caaaaaatga gtcttcatct atgacccgct caatgagctc atgcatatca 1787761 aaaggtgcgt tttgattttg cggaatgacg tcggcaagcg gagtttcgaa gtgttttggc 1787821 gggcgtttct catgaatggg cgctttttct tgaaaatttg ccggaaagta agacaaataa 1787881 gcccgcacca gctgtatggc ttcttcttca gtttctgcaa gaatatctcc gcagccggag 1787941 attgagcaat gcatacgggc gccacccatt tcttcgagag acactttttc tccaataacc 1788001 atttccgcca tccttggcga acctaaatac atggaggcgt taccgtctac cataacgacg 1788061 atatcacaga aggccggaat ataagcgcct cctgccgcag atggtccgaa aagcagacag 1788121 atttgcggaa tgcgtcccga taatttgact tgattgtaaa aaattcttcc tgcaccgcgt 1788181 ctccctggaa agacattgat ttggtcggta attcgggcgc ctgccgaatc gactaaataa 1788241 atgagcggac agtttaattt ttcggcgatt tcttgaattc tgatgatttt ttcaactgtt 1788301 tttgctcccc atgaccccgc tttcactgtt gaatcattcg ccatgacgca aacggtttgg 1788361 ccgccgattt tgccgatagc ggttacaact ccgtcagcgg gaagcccgtc tgacatacat 1788421 tccgcaaaaa aagcgtcttc tagctcaatg tcatcgtcaa agagaaggga aagccgctct 1788481 ctgacaaaga gcttgccttt ttcccgattg ctttgatgat acttttccgc tccgcctttt 1788541 cgaatccgtt cagcccgttc tgttcgttcc ttttcataat ccatcagcat tgcctccctt 1788601 ttatattccc ttgtatacgg cccgtctttt ttcttgaaag gcctgaagcc cttctctcct 1788661 gtcttttgtc gggatggttt gttcatacgc tttttgttca atcgcaaggc ctgtagcaag 1788721 atctgtctcc aatcctttat tgattgcaaa tttagcctga cggacagcga tcggtccgtt 1788781 ggcagaaatg gctgcggcca gttcctctgc ttttggcata aggtcacaag gagccgtgac 1788841 atgctctaca aggccgattt cttttgcttc gtgtgcggtc acgcgtctgc ctgtataaat 1788901 gaattctttt gcttttcctc tgccaatcag ccggggcagc ctttgggtcc ctccagcgcc 1788961 cgggataata gctaaccctg tttccggaag tcccagcaca gctgcttcag ttgcgattcg 1789021 aaggtcgcat gccaatgcca attctagtcc gccgcctaat gcgcttccat ttatcgcagc 1789081 tatgaccggc tgcggcaagg catcaagtaa agccgccgtt ctttgaatga gagatacact 1789141 ttccagaacc tgatcttctt tcagttttat ccgttccttc aggtctgccc ctgcacaaaa 1789201 cgctttttca ccggtgcctg tgaggatgac gcaacggatg tttgagttaa attcaatttc 1789261 ctggataatc atttgcaggt ttctaagcat ttccgctgaa agagcatttg ctgcctgagg 1789321 cctgtttaag gtgatcaacg ccatatgttc atttttaaca gtaaaaagaa tagaatctcc 1789381 cattgtatgc gtcctccctt ttatcaagat gatttaaaca cctgtaaatt tctgctcggc 1789441 agcggtttgc ccattttttc ttcaatccat ttggccgcag atagcagttt ttctagcttt 1789501 acatttgttt tgatatccat ctgttcaagc atgtacacga tatcctcagt tgcggcgttt 1789561 cctgatgaac ctggcgcata tgggcatccc ccaagcccgc ctgccgagcc gtcgaacacc 1789621 gtgatgccca tttggagtgc tgtgaccatg ttggccagag cggttcctct cgtatcatga 1789681 aaatgcaggg caatttgatt agccgggaat cgtgccaaaa gagcttcaag tacagtttcc 1789741 acttgggcgg gattagctgc tccaatcgta tctccaagcg acagttcaga aatcccaaat 1789801 tcaaatagag cttctgaaag gcgaatgact tgttcaatgg ggacatcttt ttcgtacgga 1789861 cagccgaaaa cagtcgagag gtaggctctt gttgtgaggt ttgctttttg tgcgtcgttg 1789921 tttacttgtt tgagtatatg gagggattca gaagtggatt tattgatgtt ttttctgttg 1789981 tgcgtctcgc tggcggacat aaaaacgcaa gcctcgttaa tgcctccttc aagtgcattc 1790041 tccagtcctc tttgattcgg gacaagtgcc gcgtacgtta cccctttttc tcggtcgatg 1790101 ccttttgcta catcgatagc atctcgaagc gccggaatcc atttcgggtg aacgaaggat 1790161 gtgatttcaa tatacgacag ccctgtccgg gaaagctggt tgatccaggt tattttatcc 1790221 tctgttgcga tccaaacggg ctcgttttgt aagccatcac gcgggccgac ttctttgatt 1790281 gtcacttttt taggatatgg catggtcttc ctccaaatta ttgagtggaa ttgctcagtt 1790341 cgagcagtac gtctccttca tttacaaagt cgccttcctt ttttttgact tcttttacga 1790401 ttccgcttct atctgcaacg atcgggattt ccattttcat cgattccaaa atggctacct 1790461 cctggccctt ttcgatttgg tcgccggctt tgacgtggac tttccacagg tttcctgcca 1790521 tttgtatgct aaccgtcatg acaactgcct cctttatagg tgctgtttca aaaagtcagt 1790581 cgtgacatcc ccttctttaa atgcctttgt tgccgcagcc tgtatgagga gcggaaggtt 1790641 tgttttgatt ccctctacac gatagtcgcg aagcgctgtc tctagttttt caattgcttc 1790701 tgttctggtt tggcctttga caatcatctt agcgatcatc gggtcataaa aaggggtaac 1790761 ggtgctgtct tttgctaccg cacattcgtg tctgactcct ttttggtcag gaagtgaaaa 1790821 cgcagtgatc gtacctggtg acgggaagaa ggtcttggga tcttccgcgt atattcgaac 1790881 ctctatcgca tgcccgttcc gttggatgtc tttttgggag aatgtgagtg tatggcccgc 1790941 agcaatccgc agctgctgct caactaagtc caggcctgtt atttcttcag tcacggggtg 1791001 ttcaacttgc agtctcgtat tcatttcgag gaaataaaaa ttttgtttct ggtcaactat 1791061 aaattcgatg gtgcctgcgt tcgtatagcc gattgccttc gctgctttta ccgctgtttg 1791121 accgatcttc attcttagtt catcgtctac aaatggagac ggtgcttctt caatgacttt 1791181 ttggtggcgc ctctgaacag agcaatcacg ttcaaacaga tgtactgtat ggccgtgttg 1791241 atcggccaaa agctgaacct cgatgtggcg cgcatgttca ataacttttt ctatatacat 1791301 agacccgtca ccgaaaaaat ctgctgcgcg ctttttgttt ccctcgtacg ctttttttaa 1791361 tgcttcttca ttttcaacac gctgcattcc gatgccgcct ccgcccgctg aagctttcag 1791421 catgacagga tagccgattt gacttgcggt gcggcaggct gcctctatat ctccgaggga 1791481 ttcagaaacg cccggcacca cagggacacc tgcagcctcc attgcttttc gcgcttcaat 1791541 tttgctgccc atctttgcga tgatatcagg ggaaggtccg ataaacacga tgttttcttg 1791601 cttgcagcgt tcagcgaacc ggctgttttc tgataacaat ccatatcccg ggtggatcgc 1791661 gtcggctttt gcttttttcg ccgtctttat gattctctct atatttaaat aactttcact 1791721 gactctcgat tccccgatca aatatgcctc tgtagcggct tttgtatggg gcgcgtcctt 1791781 gtctgcttct gaataaacag cgaccgtttt aatgccgaga cggctgcatg ttcggataat 1791841 tctcattgca atttcaccgc ggttggcgat cagtactttt gtaaacatga tttcacctca 1791901 ttgacttgat gataagttga acatttcaat cgttttttct cgcagtttat atttttgaat 1791961 tttgcctgag gccgtcatcg gatagtcatc cgtaaaaata acataacgcg gaattttgtg 1792021 gcgggcgatt ttccctttgc aataggcttt aagctcatca ggtgaaacgc ttttaccgtc 1792081 tttcagttta atccaggctg cagcttcctc cccgaatttg gcgtcaggca caccaaccac 1792141 ctgtacatct aaaacagcgg gatgctggta taaaaattct tcaatttccc gcggataaat 1792201 gttctcgccg cctctgatga gcatatcttt taatcttccg gtgatgcggc agtacccgtc 1792261 ttcatccatg acagcaagat ctccggtaaa cagccatccg tcatgattga ttgcttttct 1792321 ggtcgcatct ttgtctttat aatagccttt catgacgtga tagccacggg tgcacagttc 1792381 tccctgcatg cctctttgaa cttcttgaca tgtcccgggt tctacaattt tcacctcagt 1792441 atgtggcagg gcacggccgg ttgtttcgac tcttcttatg aaggaatcat ttgctctcgt 1792501 ttgtgtaatg actggcgagg cttcggtttg tccataggcg atcgtaatgt ctttcatgcc 1792561 catcctttca atcacagctt tcatcacttc acttggacag ggagagccgg ccatgattcc 1792621 tgttcggagc gtcgatagat catatgcatc aaaatccgga tgatgcagct cggcgataaa 1792681 catggtaggc acaccatgga gcactgtgca tttctctttt tctaccgttt taaggacggt 1792741 aacgggatca aattcttgca cgggtatcat ggctgccccg acggatacac atgccaaaac 1792801 cccaaggacg catccaaagc agtgaaaaaa cggaacaggg atgcacatgc ggtcttgaga 1792861 ggttaaagcc atacattcag cgatattagc agcgttattg atgacattga aatgggtcag 1792921 catcacgcct tttggaaacc ctgtcgttcc tgatgtgtat tgcatattaa tcacattgtc 1792981 tttatccagg ctgttcattc tctcttcaag ctcagcatct gtcactgttt tcgccaatat 1793041 ctctgtatcg tcccaatgat acatgccaga caatcgttta ttgccaatat agatcagcgt 1793101 ttttaaaaag ggatagcgtt cagatttcag ttggccgggc tttgcttctt gcagttctgg 1793161 aattaaactg ttcacgatgt ctggataaga agtgcccctg tatgaatcca tgataataag 1793221 cgccgcggca tccgattgct ttaacaagta atcaagctca tgtgcttgat aattggtatt 1793281 gacggtcacg agcacggctc cgatcttcgc agttgcgaac tggacggcaa gccattcaga 1793341 gatattagaa gcccatatgg cgacgtggtc tccttttcca atccccatcc gcatgagacc 1793401 tttagcggtt tgacggcaca gactgtcaaa ttgagcgtac gtatagcgga tatttcggtc 1793461 tggatacaca acagcatctc gatcgggata cgcatcagct gtttgttcca gcagcctgcc 1793521 gattgtggaa tggatgagtt cagccattca ttgttcctcc tttcttaatg ataggaaagc 1793581 gtttacattt ttattttaaa agctgtctgg cgatcacgag acgctgaatt tcagatgtgc 1793641 cttcaccgat ttccattaat tttgcgtccc gcagcatccg ttccacccca tactctttca 1793701 tatagcctga acctccatgg atttgaatgg cttgattgca agctcttgtc gccatttcag 1793761 atgcgaatag cttggcgtac gccgcttctt tggtgaacgg gcggttatga tctttcagcc 1793821 aggcggcttt taacaccatt tgccgtgcca gatcaatttc catcgccatg tcagcaagct 1793881 taaattgaat cgcttgaaag gaagaaatcg gctgtccaaa ctgctttcgc tctttcgcat 1793941 atgccaatga tgcgtcaagg gccgcttggg caatgccgac tgcaagagca gcgatggaga 1794001 ttcgaccacc atccagcgta tatagaaact gtttaaaccc ttttgttgga tcgccaagta 1794061 agttggccgc aggcactctt acatcttcaa gcaagatttc cgctgtattc gaaccgcgga 1794121 cgcccatttt atcgtacggg ctcgtaatcg taagtcctgg tgtgtcagtt ggcacgatta 1794181 atgcggagat gatgtttttt ccgtctttgt ttttgcctgt tacggcggtt acaataactg 1794241 tgcgtgcgta gcttgcatta gtgatccagc acttttcgcc gttgattaca tactcgtcac 1794301 catttgaaat cgcttttgtt tgagtgcctc ctgcatctga gccggcattt ggctccgtca 1794361 ggccgaatga tccgagtgct gtgcctgaag ccagcggcgt caaatgcgtc tgtttttgct 1794421 cttctgttcc gaagtagtaa agagggcttg cgcctagcga gaccgctgca gcatagctta 1794481 atccagtact gccgcaggct ttgccgactt cttcaaccgc taaggcatat gaaatcgtat 1794541 caccgccaga tccgccgtat tcttctggaa atggaatacc catcagaccg agttcaccca 1794601 tttttttaaa tgtttgcatc gggaactcgc ctgtttgatc tacatgttca gcgtgaggag 1794661 caatttcttt tttcgcaaaa tcttttacca tttcacgcac catttgttgt tcttttgtca 1794721 gctcaaaatt cacatcgttt cctccttcac atctttgtaa catcctatta ggcgagttct 1794781 ataatcattc cctgacaaga aaagtctgaa aattaaaact gaatcatttt ttatgtgata 1794841 atatcagcgg gatgagcaaa tacatgcagt aggcgcatac catccatatc gtaaacgcaa 1794901 taacttggcc ctttgataaa gccgggaaga tgaggggaag attccaaagg gaaatcgtat 1794961 ccatcaataa accgaccgct gatccccata tacctagctt gatcaccgcg aactgtgatt 1795021 gatcgagttt ttgatagaga aagaacacaa ggcataaaac aagagcagtg cccgctccca 1795081 agagaagaaa gttcggcaaa aaggcttctt cagccggatc agtcaacaca gcatctccga 1795141 acagcacaaa aaataatgtg gcacctaacc agactagaaa tgaaaacgta aaacacgtcc 1795201 tgtacgtgtt tctcttcgat tttattttta tttagtacta gtttctcaga ttccaataat 1795261 ggtaaatgtc caaacaccgc ctccatattc atgtgaatct cacctttgtt ttttaaaaaa 1795321 ttcagcggtt taccatcgtt tcctgtccca aaatcacttt ttaaaaaaag acgacttaga 1795381 aagccgtcct tctcatttct tattttgttg ttcgtttgga agctttgctt tcgttatgaa 1795441 gccggtctgc tgaagtgaca taatacgtat atttcttgtt gggatctgcc gtgttatcta 1795501 agaaggtttg ctgctcatgt gtttttcttt gcgttgccag caatgttctc tgctttttcc 1795561 cttcggctct gtatatcgca taataggctg tttctttcgt tttttgattt gatgggtgat 1795621 ctttaatctg cagaagattg ccgtttttgt cttcggtgac tttcgtaagc ttcggttttt 1795681 ttggggcggt attgtcaagc caaggcattt gcggaaccag tgccggcttg ctgtaaagat 1795741 cggtgctgag actgtctttg atgccaagcg gatttttgtt gaggtccttg aggctgaaat 1795801 gcatgcttcc tttcaccagt tcaagctggc ggttcaaagt gatttgccgc acatattcct 1795861 caggatcgga ccaaggcgga tcaaaattgt tattgatttt atatgctgcc tggccaatat 1795921 ataagtgaac aggcctattt ttgacttcat tgctccacca atcagccagc acgtcgtaag 1795981 ccgctgcgtt aaagccgata ctccaataaa tttgcggagc aatataatcg atgtcgcctt 1796041 cttggatcca atgccttgtg tctgcatata gatcgtcata atttctgacg cctgcttttg 1796101 tattcgatcc ggtcgggtca tctgcggcgt ttctccatac tccaaaggga ctgatgccga 1796161 atttgacata cggttttgca gctttaattg tttggttgat ttgtttgaca agctggttca 1796221 cattgtcccg ccgccagtca tcgatattag aaaaagcgtc ttttccgtat tgttcgtact 1796281 gtgcttgatc aggaaattcc tgtcccgcta ttttataagg gtaaaaataa tcatccatat 1796341 gaacagcatc gatatcataa tgttttacga cttcttcaat gcctttgacg ataaaatctc 1796401 tcgcttctgg aatgcctgga tgataataca gctggtttcc ataggcggca acccaatctg 1796461 gatgttttct tgccgggtga tcctcagaca atttattaag atctgtatga ttcattgtaa 1796521 tacggtaagg attaaaccac gcgtgaaatt ccaaatttcg tttatgggtt tcttcaatca 1796581 taaatgcaag aggatcatag ccggggtcct tcccttggac accggttaag tattccgacc 1796641 aaggcccgta agctgacgga taaaaggcat cagccgtcgg tttaatctga acgataacgg 1796701 cattcattcc cattttttgc acatcgtcca gcagtttgat atactcctgt ttttgctctt 1796761 tcacagataa cccttttttg gacggccaat caatatttaa tacggaagca atccatacgg 1796821 ctctcagctc cctgtcagac tgcgcattgg ccataaacgg aacggaaatg acaaacgttc 1796881 cgatgatcaa gctgacaagg aaacggacaa tcgacttttg gcaaaccttc attctgtttc 1796941 ttctccccca ttacatcact ttcactattc gctattacgg tattcccggg ctataaaagg 1797001 gtgattaaca gaatgtctat ctcactaaat aaacgaaaaa agtcctaaag catgttgtga 1797061 accgctttta ggacttttta tcattcatca tggtttgcag actttttaac acatcaataa 1797121 gttttacgcc gacaccgaca gccgtttcaa ggatcgcttg tgctccggca atggctaaaa 1797181 taaagatcag cggtattgca atacgaggca aaaaaagata gccaagtccg atcaagatgg 1797241 cacaccaaac accggcacac cagtagcaat tgagcatgta tccaaagtta gaagccggca 1797301 cgcttttttc atctacatgc ccgttttgat caacaatcct tttctttttc ataaaaggtt 1797361 ttcggataaa ttctgtgatt ttgtcaaata caatcaaatg tgtcagcctg taactggcta 1797421 gaatcagcat gataaaagtt agaaaagaaa gacggtccat tgagaagcct ccaagaaaaa 1797481 ggatgatgtt atcattccca agtgtccctt atccattctt gatacaaaaa gaaagacgga 1797541 cagagaatgg cctctgtccg ctaatccgct ttatcgtttg tgcagtatta cttgatttga 1797601 agtgatcttt tctaaaatgt cgaggatgat gtcggcattc ttttcagcat atgttccttc 1797661 cagcatgtct ttatgagcgc caaaacccgt gtactcacta tagtttccgc aggcgccttc 1797721 ccatttcgtt aagcctgtat gcccgctggt ttcggggtgg attccagctt cgatgaaatg 1797781 aatgcttgct ttgatgtggc cttcattcag caattgtgcc caatattcct gatagtttct 1797841 ttttttcttc atcacctttt ctctgactgc ttcaggcaga tatgctgcag attcgtcatt 1797901 accggtatcg ataggcaaag gctgttcttt tagataagcg tccacgataa tgaagtcgct 1797961 gacttctaat cctttgcgct ccatagcctg tgccacttca aaagccaggt ttccgcctgc 1798021 agagtagcct aataaaacgt atgggccctc aggctgtatg tccgtcatgc aattaacata 1798081 ttgttcaatg cgggtgtctt gttcaataaa gtgaaacccg tatacggctg ccttctcatt 1798141 cagcaataaa gcaaggtctt taaaataaat gccaaatccc gatatcggcg ggaagcagaa 1798201 aagattttgc gcgccgtgct ggttcagttt gatcacatgc tgttcatttg ctgctgtcag 1798261 ctgtttagaa taaagttttt cggcaagctg agcgattgtc ggatgttcga acaagaaatc 1798321 aatcggtatg tcaatgttct gctgatgttt tagtgtatgt atgacttgca gtgctcttag 1798381 tgaatgtccg ccaatagcaa agaagtcatc atcaatactg attgtgttaa caccgaggac 1798441 ttgcttccaa atgttcgcca attcttcttc aaccaagttt cttggcaata tgatgttctg 1798501 tcgtttggca ggcttatttt ctggaatagg cagcgcgctg cggtctattt ttccgtttcc 1798561 ggtaagcggc atccgctcca cacgcaccca gtgctgcggg atcatatagt ctggaagcac 1798621 acgcgccaaa tcggcgcgaa aatccgtatc tgtttttttg tgatcaccga cgtaatgagt 1798681 gtacagctgc gcctctccat ctttttctct caatgtcact gctgcttctt gaacgccttc 1798741 catttctaac aggcgcgctt ctatttcggc aggctcaatt cgttttccgc ggattttcat 1798801 ttgcctgtca attctgctga tgtattctaa gtttccatca ggcagccagc gcgccaaatc 1798861 accagtacgg tatattcttt ctccaggcaa gaaaggatga ggagaaaaca cagcatttgt 1798921 cagatctact ctgttcaaat agcctttagc gactccatca ccgccaacac aaagctcgcc 1798981 gggaacgcct attggcaaaa gacgtccttt tgtatctaag atgtaagcgg tgctattact 1799041 gattggtttt ccaatcggaa tcggccccgc atagtctctc ttcatttcaa aaaaggttga 1799101 aaaagtcgtg ttttccgttg gcccgtaaat attatgaagc gcgagatctg gacaggcgtg 1799161 tctgacggca ttcatcaggg caggagagag tgcttctcct ccgacatata acgtatggag 1799221 tccgcgaaac atgtcagctc gtacctgtgc cagctgatta aaaagagctg tcgttaaaaa 1799281 tagcactgta atgtcatttt caagcaaata cgctccaaac cgatcaggtg tcagcattgt 1799341 cgatttatca atgatatgaa ggcttgcgcc atttaaaagt gccccgaaca tttcaaaggt 1799401 gacggcgtca aagctgatag atccagtcat aataaaccgg tcatcaccgg acgcagacgt 1799461 gtaattgctg tttctgacaa gggacacgac attgcgattc gtgatcatga cccctttcgg 1799521 ccggcctgtt gatcctgagg tatacatgat gtacgcaaga tcatccgggc tggagctgat 1799581 attaataggg atatcgttct cttccatcaa tccctgcgca tctgaaatga tacatgttcc 1799641 tgagaacgca gcgttttgct ccaatccctt ttgaacaatc agcatttttg cctgcgtttc 1799701 ctcaagcata aagctgactc gttcaggcgg aagctccgca tcaagcggga ggtatgctcc 1799761 ccctgctttt aatacggcaa gcacactgat catgaattcg ggagaatgtg cagccaatat 1799821 tccggctgtc tcgtttttcc gaaatccctt ttgaattaac tctctggcga gcgcattaga 1799881 gcgtttatca agctctttat acgaaataga catattgcca tacacaagtg cggtatggtc 1799941 tggcgtcttt tctgcttgtt cgcgaaataa atcgataatt gtatgattct ttggatactc 1800001 cgtttttgta ttgttgaact gtgtgacaat ctgctctttt tctgttgcat caagaaaaga 1800061 aaaatcagca attggcatat gagggtgctg tgcagctgtg ctaagcgctt gcgtaaattg 1800121 cctcttgata cagctgatcc aggcagcatc gtaaacgaat gcattatagc tgaacttgat 1800181 gacaagctct tcgccaggag caacgacaag attaaagtta tatcctgatt gctcggatac 1800241 ttgaacttga tcgatttgca gcggtgaatc ggtttgatca gcggaatcgg cgattttctg 1800301 ctgtaacgga tagttttcaa agacgataat gtgatcaatc agttcctgtt ttaatgcggt 1800361 gtttgcctga atatcaaata aaggctggca ggtaaacggc tcagcttcca gcatttcttt 1800421 ctggcagcgt atgagcagct cgtgaaacgt ttcgtcttgg tgtgttttaa ttcgaatcgg 1800481 tatggtattg ataaacaacc ctatcatttg ctccacgcct gggatttctg acggtcttcc 1800541 tgatacaact gcgccaaaca caacgtcgtc tgtgcggtta tattgctgca gcatcacacc 1800601 ccagactgcc tgaataaggg tagcgagcgt gacgccgtgt tgtttggcag tctctttcag 1800661 cttgtctgtc agtggtttat ttaatgaaaa tatcaaatct tcacggtgat aactttcttt 1800721 tgtttcttta tcagacacac gaggcagagg tgatggagcg ctgtagtttt ttaaataggt 1800781 atcccagtag gccgctgctt tttctttgtc tcggtttgtc agccatgaaa tataggtgct 1800841 gtacggacgg acagggtcta atgaaagcgg ttttcctgca tgaatcgatt gataaatttg 1800901 cataaattcc tgcataacga tacctaggca ccatccgtcc attaaaatgt gatggtgact 1800961 ccagatacag acatgctcat ctttagctgt tttgaataga gaaatccgca tcagcatgtc 1801021 tttttgcaga tcaaagcctt tttgcttgtc cttctcttta aagcgttcaa tatactcatt 1801081 ctggtcgttt gtcggcagat gagaaatgtc ttcgctgttc aaatggaatt cacgttctgt 1801141 catcacgact tgccgaggtc ccgacaaatg cgggacgtgc ggcaaaaaca cggttctgaa 1801201 aatatcatgg cggtcgataa tggcttgaat gctgcgctgg aaccagtcat agctgaggct 1801261 tcctttaatg gtgaagagcg actgctcaac atacgccccc tcctctttac ggaggaagga 1801321 atgaaacagc atcccttcct gcatatgact cagaggataa atgttcttga tttttttaat 1801381 ggtattcata gtgtctgcac ctttcttcac ggattcatta gtgaaaactg agcatatcag 1801441 cgatctcttg cagggcgtcc tcggtcagtt cttgatcatc aaaatcactg atcgtctttt 1801501 ctgtttcgct tttgttctgg cagtgttcga tcagctgtaa taaaaattga cggcatgttt 1801561 cgctaagctg ttcgatggtt ttgcgctgaa agcgggcatt gtcataagtc atattgacag 1801621 tcaattttcc ttctgcagcg attgcgctga tatccagcga ctgttcacgg ttccatgttg 1801681 tgctgatatc acctccggca cccagcggag agaatgagaa ggcgtcctcc tcaggtactt 1801741 cagctgtgcg gccgctttca aattgaccaa gataattaaa gctgatttct ggtgcacctg 1801801 tgaaattgat gtcttttttg ccaggcggag tcaaatattt gatgacaccg tagccgaatc 1801861 ctttgtcagg tacacgtctc agtgtatctt ttgttgtttt tagcacatga accatgcttt 1801921 cttccgaatc tggcaagtct gcgttcagtt taatcaataa cggataaatg gcggtaaacc 1801981 atccaatcgt ccggctcaca tctattcctt ttaatacatc ctctcgcccg tggccctcta 1802041 atgatagttt gaaggcggat tgattggtcc aatggcgcag cgcaagaatg acagaagcga 1802101 gcagcatgtc ctgcgtatca gtgttatatg cgctgttggc gtcttttaag agtgctgctg 1802161 tctctttatc gtttaaggta aacgaaattg tggaccgttg tccctcgtgt gctctagttc 1802221 catcgatttg atcaaaaggc aatgcctctg tttgatactc ttcggcttcg cgccaatact 1802281 tgagctgttt cattagctgc tggctttcag cgtagtcaga gagctttttc gcatacgctt 1802341 taaacgagct tgttttaggc ggcagtttga tatcctcccc gccagcagct tggcgatacc 1802401 ctaaagccaa atcttcaagc agaacccgcc atgagatgcc gtcaacgacg aggtgatgag 1802461 cagataaaaa taagaaatca ccgtcaattg tgtggaaaag accggcttgc agcagcggac 1802521 cattcttcaa atccattttc tgctgaatat caagtacatg gcgcttgata agaggttcat 1802581 acggtctatt tccatcagtg ccgtccggag ctgacaaatc aatcatctga aggccgtaca 1802641 acgcgtcgtc cgaatgactg agcggccgat tatattgatc ccactttcct tgttcattct 1802701 gtgtaaacac cattcgcagc gcatcatgat gacacgttat tgcttttaac gtttttcgca 1802761 gtgcgtcttc ttgtacagag gtgcttcgat gcagcattac ggactgatta aaatggtgtt 1802821 tttcttttat atcttgagaa agaaaccatt tttgaacagg cgaccattgt acgtctccct 1802881 caaccgcagc ttggctggaa cttgtatctg aatcacggat ataagctgcc aattcttgaa 1802941 tggtcggatg gctaaacaaa tctttcactg ccatttgctt gcctatccgg tgaagccgcg 1803001 cagatacctg taacgctttg attgaatctc cgccaagttc aaagaacgaa tcagctgttc 1803061 cgatcttttc tgcccccagt acttctttcc atatatctgc cagtatttgt tccattttgc 1803121 tggatggcgg gaggaatgga cgttcacctt cgtggttgta tacaggtttt ggaagtgctc 1803181 cgcgatccag cttgccgttt ggtgacaatg gaagtgagtc cagtttttca ataaacgcag 1803241 ggtgcataaa caccggcagc ttgttttgta attctgagcg tacagcattt gtgctcaacc 1803301 ctggttttgt caccacataa gcgcttaatt cggtttgtcc tgacgctgtt acatgagcaa 1803361 ctactgcggc gtcttttaca ccctttatac accggatgac cgattcaatt tctttcgttt 1803421 ctacacggta tcctctgatt ttgacttgat catcgattct tccgagatat tcgagtgtac 1803481 cgtcggccat ccatctggcg gcgtctcctg ttcggtacat tcgtgcttcg ggtttaaatg 1803541 gattctgcgt gaatgctctc tctgtcagtt ctggaagatt aacgtaccct cttgcaagcc 1803601 ctgttcctgc tatacaaagc tctcccgcaa caccgattgg ctgaagctga tgattgctat 1803661 ttaaaatcag cacttgagtt ccgtcaatcg gctggccgat gcttacgtat gcctgctttt 1803721 ccatatgtct catgacggta gtcgccacgc tgttttctgt cggtccatat tcgttggcga 1803781 gttcggtatg cggacatata gctaagctgc gggcgatcaa ttcgcggtca gccgcttctc 1803841 ccgccagtgt gacgactcta agcgtcttta catcttccgg ctgcactacg tccaaaagcg 1803901 ctcgatataa aacaggcaca ataatcatat gtgtaatccg ttgacgagac agctgatgct 1803961 taatggccag aatatccttc gcttcctctt catgaagcaa aacggctttt gcacctgaca 1804021 aaagcggtgt aaacatacta gttataaagc cgtcaaatga gaaagaaaag agctgcagaa 1804081 tggtatctgt ctcgttgaat gcataagcgt ttcgccgcca ctgaagagtg ttagcaatcc 1804141 ctttatgctc gaccattacc ccttttggac ggcccgtcgt tcctgaagta taaatgatat 1804201 aagccaaatg atgggcagac gacatttgcg gcagcggcga tttgtcgtct tcctctacgc 1804261 tttctatcgt caagatctct ccttcaaagt cagcaagtac tcccagatcc gcttcattta 1804321 ttgtcatcag cagtttcgtt ccgctgtcgc tgaggatata gcgtttccgt tctttcgggt 1804381 attcaggatc aatgggaacg taacagcctc cggctttcca cacaccaagt atggatgcta 1804441 tcatactgaa cgaacgatgc atcatgatgc ctactggtgt gtccggctta acacctcggc 1804501 tgcgcaatgc acgtgcgatt ccattggacc actcgtcaag ctcctgataa gtgagtgttt 1804561 tgtctccgct gacaagtgca gaagcttttg gtgttcgtgc agcttgctgc tcaaacaatt 1804621 gactgattgt ttgaactccg tattgattcg cttgcccggt gttaaactca ttaagcagct 1804681 ggtgccgctc ttcttgggtc aggatgtcga tatggttgag tgtcaccttc gggtttttgc 1804741 cgatgatgct aagtacattt gttaaatgcg atgcccagcg ttcaatggtg gttttctcga 1804801 acaatgcggt tgaatattca aaaaggaaat gaatgtttcc gtcgccctca gatgcctgta 1804861 gtgtcaaatc gaatttagaa acgagatgag aaacttgtgc cggcttcatt tgcaaatcat 1804921 gaagatgcaa tggctcgtaa tcattatttt gaacaactaa catcgcatca aacactgggt 1804981 tccggctcat atctcgtgtc aattcaagct tatcgacaag ctcttcgaac gggtaattct 1805041 ggtgctcaaa ggcttccaat gctgtctcac gcacttcctg caaatactgt acgaatggct 1805101 tcccgccctc cgggcgcgtc cgaagcgcca gcgtgttcac aaacatgccg agtatcggct 1805161 caagatcctt gtgcggccgg ccggcgattg gcgagccgac gatgatatct tcctgtccgc 1805221 ttaagcgtga caagaacgcg gtgtaagccg caaggagcac catgtacagt gtgcttccgt 1805281 tttctcgtgc cagcttgtga aggcctgatg caacctctgg ttccagcgta aatgagacct 1805341 tgtcacccgc gaagcttcgc accggcgggc gggcatgatc agcggggaga tccagcacag 1805401 gcagctcgcc ctcgagctgc ttcagccagt acgcctcctg cattttgtac gcgtctcctg 1805461 ttttgaatcc ttcttgccat acggcataat ctttatattg aatgcgcagc gccggaagct 1805521 tccgattatt gtacagctcg ccgaattctt gaatcagaat gttgacggaa acaccgtctg 1805581 aaatgatgtg atgcatatca accagcaata ggtgccgctc atctgatacc tttacgattt 1805641 gggcacggaa cagcggcgct tggctgagat caaacggttt gataaatgcg gctgcggcct 1805701 cctgttcggt tcgtgcgccg agaactgtag tctgtaacgt aaacggcacc tcgtcatgga 1805761 tgcgctgcac cggatcgcct ccttcgtcct gttcgaagga ggttcgaagc gactcgtggc 1805821 gcttgatcag ctcttggaaa gctctgtcca tcctttcagg gttgagcttc ccttcgagct 1805881 ctaacacagc cggcatattg tagcctgtcc ctccgtcctc cagctgctga aggacataaa 1805941 tccgcttttg ggcagaggaa accggatagg tttcctgttt ttcagcgggc ttaatcgctt 1806001 catatggact gtccgttcct tcacggataa cggtagccag tccttctacc gtcggatggg 1806061 caaacacatc ttttagcggc acctgtacat cgaattcttt ggtgatccgt gagacaagcg 1806121 ccgttgcttt taaggaatgt cccccgcggt caaaaaagtt gtcgtgaatc ccgacagggc 1806181 catttttcag cacgtcctcc cacagctgag aaagcttcat ctcagtcacg tttctcggcg 1806241 ctgtgtaggt ctccgcatct gccgctccgc caggagctgg cagggcgttt cggtcgagct 1806301 ttccgcttgg cgtaaccggc cactgttcca tctctatcat ataggctggg accatgtagc 1806361 ccggcaacag tctctcaagc tgcgctcgga cttcgtttct ttggagccct tctacataag 1806421 cgcataattc cggctccccg ctgtctgtcc gtacggtaac ggccgcctct cttacacctt 1806481 ctatacttct tagtgccgct tcaatttctc ccggctcaat ccggtagccg cggattttca 1806541 cctgatcatc cgtgcgcccg aggaattcaa cattcccgtc agggagccag cgcgccacat 1806601 ccccggtttt gtacatgcgt tcacccgggt aaaacgggtc ttcaagaaaa cgctcctccg 1806661 ttaatgccgg ccgattcaaa taacctctgg caacacccgc tccggctatg tacagttcgc 1806721 cgatacatcc aacaggcagc atccgctgat tctgattcag gagatataat ctgacatgat 1806781 gaacaggttt tccaattggg atccgttcaa gtttttcatg cggcggacaa tcaaagaatg 1806841 cagcttctac ggttgcttcc gttggcccat aggaattggt tattgaaaca tttggaagca 1806901 actcgtaaaa tcgggagaca agatgggtcc ccagctgttc tcccccagaa aacactcgct 1806961 tgagtctgtt tgtcttaatc ggtacagagc gatattttat atgttctaaa aatgcatgga 1807021 gcattgaagg cacaaaatgc atagctgtga tcttttgttc ttctatggcc ttcgcgatca 1807081 cttcaggttc tttttcgcct ccctgaggaa gcagataaac agaagctccg gcataaggcc 1807141 accaaaacag ctcccatatt gaagcatcga atgaatatga tgttttgtgc ataatcatat 1807201 ctgaatgctt tagctgatag cgggactgta gggaattcaa aaaattcacc gctgatcgat 1807261 gttcaatttc aacaccctta ggcatcccgg tagagccgga tgtatagatg acataggcta 1807321 aagattgcgg gagaacatcc acattcggat tggacaaacg atgtgccagt ccgctatttg 1807381 tctgattgag atagacaatc tctcctgtaa attccggaac atgaaggccg gcagactgaa 1807441 gcaggagaat gtttgtaccg ctgtcctcca gcagaaagct gattcgttct tccggataat 1807501 ccgggtcgat gggcagataa gcgccgccag ctttaagaat gccataaatg ccaagcagca 1807561 tttcaggtga acgctttcct ataatggcaa cagtcgtttc gggttttacc ccccgtccga 1807621 tcagctccca ggcgatacgg ttagcctgtt cgttcaattc tttataggtc atcactccat 1807681 cttcgaagat aacggccgcc tgatcaggcg ttttttctgc ctgctgttcg agtgcatagt 1807741 ggagcgtttg attcattgaa tagcccgtct cctcaaacag atggcatgat tcaatgaaat 1807801 ctcgctcttc ttcttttgtt aagattggaa tattgtccaa ttctgtttca ggactggcag 1807861 ctgtatgttc cacaagcgtg gtgaaaaggc tggcccacct ttggatggtt tctttctcaa 1807921 acaaagctgt actgtattca aactgacaga aaagctcgga atcatgctct gtaacgtata 1807981 gggaaatatc aaattttgat attgggtgct ccaagtcgtt ccactgaagc tgtacatcat 1808041 tcatttttag cttttgctgt tccatattct gaaggactag cgttgtgtca aacaaaggat 1808101 tccggctcat ttcccgctgc acaccgagtt tgtccacaag ctcttcaaac gggtaatcct 1808161 gatgctcata cgcttctagt gccgtctgtc tgacttcttt cagaaattcc tcaaatgtct 1808221 tattacccgc cgggcgtgtg cggagagcca atgtattgac gaacatccca agaacagctt 1808281 caaggtcggc atggggccgt ccggcgatag gtgaaccaat cacgatatca tcctgaccgc 1808341 ttaaccgaga caaaaaggct gaatacaaag cgagaagcgt catataaagc gtgcttctgt 1808401 ttttatgggc gagccgcttt atgcgggccg tgatctcttt gtccaattga aaggttactt 1808461 ttccgcctat gaattgccgt tctgccggac gtcgtttatc tgttggaagc tccagtatag 1808521 gaaggtcccc gctaaactgc tgctgccagt aagtctcctg cttttggtac gagtctccct 1808581 ttttaaattt ctgctgccat acggcgtaat ctttatattg gatccgcaat ggcttaagct 1808641 gccggtttgc ataaagatcg gtaaattctc ggattaggag ctgaacggat acgccatctg 1808701 aaatgatatg gtgcatatcc accagcaata catgcttctc gtttgacact tctataaggc 1808761 ctgctctaaa taatggcgcc tggctgagat caaagggacg gacaaatccc tcgatagtgg 1808821 tctctttact taacgtaaac ggcacttcgg tgtggatacg ctgaaccggc tcgtcatcag 1808881 ctccggatac aaaggaagtt cgaagcggct catgccggct gatcagttct ttacatacag 1808941 cagacagttt ggcgacatcc agtgcacctt ccagttctaa gaccgcaggc atgttatagg 1809001 cgacaccctc atcaagctgt tgaagcacat agattcgttt ttgggccgaa gatacaggat 1809061 atgtatccct tttttctgct ggttcaattg ctgcatacag attttgttct gcctctcgaa 1809121 taattaaagc taatccttca acagtcggat gagcaaagat gtccttaagt gaaacttgca 1809181 catggaattc ctttgcgatc cgtgacataa gcactgttgc ttttaacgag tgaccgccat 1809241 tgtcaaaaaa gttgtcttgg atgcctatat gcccattctt tagcacatct tcaaatagtt 1809301 gcgaaagctt tgcctctaac agatttcgag gggcagtata tgggtttccg ctgattgaag 1809361 catctggctc cggaagtgct gcgcgatcta cttttccgtt tggggtaaga ggtatgctgt 1809421 caacccatat ccatttcgcc ggaatcatgt attctgggag ctcactagcc atataactgc 1809481 gtaaatctat tgtgttcagc ttttgtacac tgcaatagta agcgcataat tcatgttcac 1809541 cgttttgatc ttgccagatg agaatggcag cctcactaat gtccggatga ttcattagcg 1809601 tgacttcgat ttcttgcggc tcaattcgat aacctctgat tttcacttga ttgtctgccc 1809661 gtccgatata ttcgatgttg ccgtcttcaa gccgtctggc caaatcacct gtccggtaca 1809721 tgatcacatc aggcttgaat ggatcggatg aaaatttgtc gcttgtcagt ttatcgtgat 1809781 tgacatatcc tctggcaaca cttgcgccgg aaatatagag ttcgcctggt acgccgcatg 1809841 gctgaagctg tttttgatga ttcaaaatat atagatcagt acagcctatc ggtttaccga 1809901 ttggcggaag ctcaggaata gggtctccag gatgaatggt atacgtagat accacatgag 1809961 tttctgaagg tccgtaatga ttgtgcaggt gtatgccgcg tttacgcaac acatcttgga 1810021 aaaggtctga aatcattaat tgttccccgg ctgcgatcag gtgtttgacg ccatcaggaa 1810081 acgagttcgc aagttctcgc tcgctgaaaa tcattttgat aaaagcagtt gggagaaaca 1810141 caatattcgt ctgatgcttg tttataaatg caaacagctg aggcacatct ctttttatgg 1810201 cttctggcac gatgtggagt gtgccgcctt tcagaagcgc agaaaatatt tcttgatagc 1810261 agacgtcgaa ggaaggcgtc gcaaattgca gaacatctgc ttcaaagtca atgccggagt 1810321 gagtatattc gaacttcagc aagttagcca tgtttcgatg ctcaaattga acaccctttg 1810381 gtttacctgt tgtgcctgat gtataaatca tatacagcag atcgtcagca ttgttgactg 1810441 actttatgtt actgccgtct actttgcttt cgatatcttc tggatgagtg ataatgtaat 1810501 tgtcttctaa cgatgaggga agatgcgctt gtgaaacaac atgcgaacag ccgcaatcat 1810561 gcagaatata acggattctg tcagcagggt aatgcggatc aaccggaaca atggcgccgc 1810621 ctgctttcaa gataccaaga acacctgtga taaacgccgc tgagcgttcc atcataatcg 1810681 caacgggttc ctgtctcaca acgcctttca ttcgtaaatg ccgtgccaat ctgttagccg 1810741 ctttattcag ttctctgtat gttaatgagc aggcttgatc aattacagca tgagcatctg 1810801 gtgtcttttc cgcttgcttt tcaaacatgg catggatggt ttcgtaaact ggtgtttgat 1810861 ctgtgatttc tccaatcagc tgccgctttt cagtatctgt cgtgatatcg atttcttcag 1810921 gtggaagatt cggattattt aagatttgtg atacagcatt cagaagatgc tctttgacag 1810981 agagcacaaa agaccgatcg tgctgctccg catcatagtt cattttgata tgaatttctt 1811041 cccctggcgc caccataaga taaaagctgt agttggtttc atctgcgaca gtgaaattat 1811101 gaatctgaaa aagatcagaa gcatgttcct gtttgttcag catttgaatc tcttgctgca 1811161 ccggatagtt ttcaaatacg agaatatgat caatcagccc ttgcttaaca gctgagcggg 1811221 attgaatctc atataaaggg tggtagctgt acgcttcagc ggcaagacgg tctttttgca 1811281 tatcttttat aagttgaaga aaaggcgttt ttgccccctg cacccgaacc ggcatcgtat 1811341 taatgaaaag acctaccata tgttcaatgc cttcgatttc tgcgggtctt cctgaaatga 1811401 cagaaccgaa tacggcgtca tcgttattat tatatttttg cagcagaatg ccccaaatgg 1811461 tatgaaaaat cgtactgagt gtcacttctt ctctagcagc aagctctgaa agcctgctgc 1811521 tttcttcctt agagaatgaa aatgtaacgt gttcctgcct gctttttccc tttgtttttt 1811581 tctgcttcgg gagcacggtt tgctgttcgt ggccggaaag ataatgatcc caataagaaa 1811641 ccgcctgctc tttgtcttgc tccatcagcc atttgatata ctttccgtat ggctggaccg 1811701 gctccaatgt tattggggat gcatttacat aagatgcgta aatatgcaga aactccttta 1811761 gcacaatgct gaggcaccaa ccgtccatca tgatatgatg aaaggtccaa atgcaagagt 1811821 actggctctc tcctgtttga atcagagcga tgcgcatgag cacatccttt tgcaaatgaa 1811881 acccccggtc ccggtccttt tctttccatt gctcgataaa ctgtgattgc tccgcctcgt 1811941 ttaaatgagt aatgtcttct tccagtacga tgacatttcg ttctctcaga acaacctgct 1812001 ggggggagga aacattttgg ctgataaaaa tcgttctgaa aatatcatgt ctttctacaa 1812061 gagcgttgat gctgttttga aaaaactgcg ggttgacttt tccttctatt gtaaaagaag 1812121 cttgctcaac atacgcctgt gaatcttttt gcaggaggga atggaaaagc atcccttcct 1812181 gcatgtaaga cagcggataa atatcctgaa ttgaattcgc ttttgtcatg ttcatgtctc 1812241 ctgtcacgat tttctacaat tcttccacca agctggatat gctgtccaag tcctctgccg 1812301 ttaatgattg actgctgaaa tcgctcagtg tcttttctgc tttctgttga ccggcgcagt 1812361 gtttcataat gtccagcaaa aagtgttcaa tcctgttaat aagctgttcc attgtgtttc 1812421 tgtgaaagcg ggctggcgga taactaagat tgaaatggag ctttttgtct gctgccattg 1812481 cactcatctc gatgatttgc tcgcgcttcc atgtatgagt gatatccttt ccgctaccaa 1812541 ggcttgatgg gcggaaggtg tcctgtcttt cgatgtcgtt gaactggccc aaatagttaa 1812601 agctgatttc aggtgttttt gaaaacgtaa tgcttttatt ttcagggtgt gtaaggtatt 1812661 tcagcatacc gtaacctacc cctttgtttg gtatccggcc cagtgtatct ttaacggttt 1812721 ttactgaggt tccgagctca tccctatgat tttcaaagct tatgagggcc gggtacatgg 1812781 atgtaaacca gccgaccgtc ctgcttatat ctaactctgg cagaatgtgt tctctcccgt 1812841 gtccttccat agcgatacgg agcttgcttc ctcctgtcca ttcacaaatc gccaaggatg 1812901 ctgcggttaa cagaatatct tgtgtatctg tgccataggc gtgattgacg ttttgcagca 1812961 agacggcggt gtctgcttca gtcagtgaaa agcttaatga gtcccttttg ctgaagtcga 1813021 tgttcacatg atgcggtatt tcatagggca gttctgcggc ttgctgttct tctacacttc 1813081 gccaatacgc ctcttcgcga atcagcttac tgctttgggc atattcctgt atgcgtcttg 1813141 cgtattcctg gtaggaatcc gttttaggcg gaagctggat cgtctggcct gcagcagctt 1813201 gttgatatcc ggctgacaaa tcctccagca aaatccgcca tgagacacca tcaacgacaa 1813261 ggtgatggat cgcaaggaac aagtaatctc cggtcagtgt tttaaacaaa gcggcgtgca 1813321 acaatggtcc ttcctgcaaa ttgatgcttt gctgaagatc ggcaacttct tgtttgattt 1813381 tcgtctccca gccgctttct gactgtgaaa gatcagagat tcttaagctg tatagctgtg 1813441 actcatgaat gccttggttg atttgaatcc atcgcctgtc atcgttgcga taaaccatcc 1813501 gaagcgcatc atgatgctcc gccagttttt tcaaggctgg tctaagggcg ttttcagaca 1813561 aacgtccaga atggaatagc atgacagact gattgaaatg gtgtctttct tcaatatctt 1813621 gtgaaaaaaa ccattgctga acaggcgtcc aaggaacgtc accctgaatg ggtccttgct 1813681 ctatgattct ctctgactta cggataaatg gtgataagtc ctttatcttt ggatgacgga 1813741 ataaatcact tacctgcaag cttagtccat agcgcccaag gcgtgcagaa acttgaaggg 1813801 ctttgattga atctccgccc aattcaaaaa acgaatcctc tattccgatc ctctggatgc 1813861 ctagaacctc ctgccagatc aatgccagct gctcttcaag ttcgttgcgt ggcgggatgt 1813921 atgtttgttt agatgcgaca tctggttcag gcagtgcttt ccggttcaat ttgccgtttg 1813981 atgtgagcgg aagagtctcc atttcaatga tatacgccgg gatcatatag tttggcagcg 1814041 aacgcgcgag aagagaacgc acttgttcag cattcgtgcc tgcttttacg ctgatatagc 1814101 caaacagctc tttgctcccg gtctgggctg tacgtgctaa cactgcggct tctttgaccc 1814161 cgtctatttg acgaagtgct gtttcgattt cacccagctc cacccgatag cctctgactt 1814221 ttacttgatc atcaatacgg ccaacgtact caattgtgcc atcggaaagc cagcgcgcca 1814281 gatcacctgt gcgatacagt cgatcgccag gtgcaaatgg atgtgggaca aatttctctt 1814341 tcgttaaatc aggacggccc aaatatcctc tggcgacgcc atctccgccg acacaaagtt 1814401 caccgacagc tccgaccggc tgcagcactc cccattgatt taagataaaa gcggtggaat 1814461 taccaaccgg ccgcccgatc ggaatggaaa gttcatatgt tttttgaatg tgaaggcatg 1814521 tcgaaaaagt tgtattttcg gtagggccat atccattcca tatagatact tcagggcaga 1814581 catttctgat tcgattgacg tggctcggcg acaaagcttc tccgccaata atcaaatgtt 1814641 tcagctgtga aaatgtttgt tcattttgct ctgtcaaatg attgaataga gaagatgtca 1814701 gccaaatcgt tgtgattcct tgatgttcta tgtacctctt aagctgatgg gaatcgagaa 1814761 atgtttgttg atcggacaga tgcaaagcgg caccatttag cagcggtccg aaaatttcaa 1814821 atgacccaac gtcgaaaccg attgatgatg tcatcagaag gcggtcttca ggtgtaaatg 1814881 taatataatt gctgttttta acaagacgaa ttacacttcg ctgctcaatc atgacaccct 1814941 ttggtttacc ggttgatcca gaggtataaa tgatatatgc aagtgaatgg ggccctgctg 1815001 aagattcaac gttcttcgcc tctccttgct tttgaatatc ttcgattatg atttgttcac 1815061 attcaatgcc taatagccgt ttttctgttt tttcagattg aaggagtaat gctgccctgc 1815121 tgtcagacag catataagct atgcgttcaa caggcagatt agaatcgata ggcagatagg 1815181 ctcccccggc ttttagaatg cccagcattc ctgcaatgag ttctggtgtt ctgcctgtca 1815241 acaaggctac aacactatca ggccctacgc cctttatctg tagaactgag gcaatttgat 1815301 ttgcccagct gttcaggtcc tcgtaagtga atacttgggt gtcgctgaca attgctacag 1815361 cattaggtgt ttgttctgcc tgcatttcaa agagtctgct gatggtttca tttcttggat 1815421 aatctatttt tgtacgattg agctcgtgga taaggtaatg ggcctcatcc tcattcagga 1815481 tatttattgt tccgagagcg gctttgttgt ctttgatgat ggagagtaac atattgttga 1815541 agtattgaag ccacttttct atcgtttttt tcttatataa gtcagtacta aactccattt 1815601 ggaacgtcag caaaccgcgg ggctgttcct gggcatatag ggttaaatca aatttggacg 1815661 tttgatgccc attgtttgct gcaggtttga gacaaagttc atccagctcc aacgattcct 1815721 gatccatatt ttgaagaaca aacattacgt caaacagcgg atttctgctc atatctcgtg 1815781 tcaattcaag cttatcaaca agctcttcga acgggtaatc ttggtgctca aaggcttcca 1815841 ttgctgtctc gcgcacttcc tgcaagtact gtacaaacgg cttcccgccc tccgggcgcg 1815901 tccgaagcgc cagcgtgttc acaaacatgc cgagtatcgg ctcaagatcc ttgtgcggcc 1815961 ggccggcaat tggcgagccg acgatgatat cttcctgtcc gcttaagcgt gacaagaacg 1816021 cggtgtaagc tgcaaggagc accatgtaca gtgtgcttcc gttttctcgt gccagcttgt 1816081 aaaggcctga tgtaacctct tgatccagcg taaatgagac cttgtcaccc gcgaagcttc 1816141 gcatcggcgg gcgggcatga tcagccggaa gatccagcac aggcagctcg ccctcgagct 1816201 gcttcagcca gtacgccccc tgcgttttgt acgcgtctcc tgttttgaat ccttcttgcc 1816261 atacggcata atctttatat tgaatgcgca gtgccggaag cttccgatta ttgtacagtt 1816321 cgccgaattc ccgaatcaga atgttgacgg aaacaccgtc tgaaatgatg tgatgcatat 1816381 caaccagcaa caggtgccgc tcatctgata cctttacgat ttgggcacgg aacagcggcg 1816441 cttggctgag atcaaacggt ttgataaatg cggctgcggc ctcctcttcg gttcgtgcgc 1816501 cgagaactgt agtctgtaac gtaaacggca cctcgtcatg gatgcgctgc accgggtcgc 1816561 ctcctgcgtc ctgttcgaag gcggtccgaa gcgactcgtg gcgcttgatc agctctttga 1816621 aagctctgtc catcctttca aggttgagct tcccttcgag ctctaacaca gccggcatat 1816681 tgtagcctgt ccctccgtcc tccagctgct gaaggacata aatccgcttt tgggcagagg 1816741 aaaccggata ggtttcctgt ttttcagcgg gcttaatcgc ttcatatgga ctgtccgttc 1816801 cttcacggat aacggtagcc agtccttcta ccgtcggatg ggcaaacaca tcttttagcg 1816861 gcacctgtac atcgaattct ttggcgatcc gtgagacaag cgccgttgct tttaaggaat 1816921 gtcccccgcg gtcaaaaaag ttgtcgtgaa tcccgacagg gccatttttc agcacgtcct 1816981 cccacagctg agaaagcttc atctcagtca cgtttctcgg cgccgtgtag gtctccgcat 1817041 ctgccgctcc gccaggagct ggcagggcgt ttcggtcgag ctttccgctt ggtgtaaccg 1817101 gccactgttc catttctatc atataggctg ggaccatgta gcccggcaac agtctctgaa 1817161 gctgtgcacg cacttcgttt ctttggagcc cttctacata agcgcataat tccggctcgc 1817221 cgctgtctgt ccgtacggta acggccgcct cccttacgcc ttctatgctt cttagtgccg 1817281 cttcaatctc tcccggctca atccggtagc cgcggatttt cacctgatca tccgtgcgcc 1817341 cgaggaattc aacattcccg tcagggagcc agcgcgccac atccccggtt ttgtacatgc 1817401 gttcccccag gtaaaacggg tcttcaagaa aacgctcctc cgttaatgcc ggccgattca 1817461 aataacctct ggcaacaccc gctccggcaa tgtatagttc gccggcgaca ccggaaggct 1817521 gtacggctaa atgcggatct aaaacataca aacgcgcacc aggtacgggc ttcccaatcg 1817581 gaatccgcaa acggtctctg tcccgttctg gatctaacac gtaaaatgcc gcgtctaccg 1817641 tggcttctgt cggcccgtag ccatggatta atgatacctg cggcaataca gaagcaaaac 1817701 gggctgccgt acgcggcgca agcggttcac ctccggcgaa tacacgcttt aggcttgtcc 1817761 tgtcactcag cctttcgatt tccgcttgat cgagaaagct gttcagcata gccggaataa 1817821 aatgagccgt tgtcacgttt tcctgatgaa tggcttgtac gatcaatgcg gagtcttttt 1817881 cccagccggg cggaagcaga tacgccgaag caccggaaag agcccaccaa aacagctgcc 1817941 acacagacgc atcaaaggaa aaagaggttt tcaccatgac aatgtcatct tccgaaagcc 1818001 gaaactggtg ctgcatgccg gtcagaaagg aaacagcctg gcggtgctca acggccactc 1818061 ctttcggctg cccggtagag cccgatgtat agatgacata ggcgagagat ccgtcgctaa 1818121 cagaagcaga cacatgacgt tttacttctt cacactcaag agatgtcatg tccacttcaa 1818181 gcgtttcgcc agaaaagttt ggtgcggagc atcccggctg tgtcagcaag agcgatgccc 1818241 cgctgtcttt cagcatgtag ctcagccgct cctttggata cgcaggatca agcggcaaat 1818301 acgcccctcc ggccttcaat acagcaagga cagcgatcag catgtcaggt gagcgttcag 1818361 acaggacacc gacgatactt tcgtttgtga cgccgcgtgc cgcaaggtgc gcagccagcc 1818421 ggctggcgta catatcaagc tcagcgtatg tcagcgaacc gcctgaaaag cgaatggcca 1818481 gccgctccgg tgtgactgcc gcctgtcgtt caaacagccc atgcagggtt ggggcttcag 1818541 gtgaaacaga tactgtcctg ttattttgag aaacgatttt ccgtgttttg tcctcatcta 1818601 gcaacgtcat ctttgacaca ggaagagatg gatcagagat gacgtcagag accatgtgca 1818661 gcaaataatc ttttatttcg gacatcatgc ttggttgata agcgctggtc tgaaaatgaa 1818721 tccgaacgta caaggtacgg cctgggatca ctttgacact gcaactataa ttggtcacct 1818781 cttccatctc aaaatctttg acggagaaat caaatgaccc cgcttgattc agctcttcga 1818841 tctcttgctg ggtaggtgta ttttcaaaga cgataatatg atcgatcaac tcttgcttta 1818901 gagcactctg cgcctgaata tcatacaagg gaaagtaact ataggcttct gcctcattca 1818961 tgtccttttg cattctcctg actaggtcag aaaaagacag agaatcactt tgggctcgaa 1819021 taggaatggt attgataaaa agcccgacca tgttttccac atcttttagc tcagaaggtc 1819081 tgcctgatat aactgaaccg aacacagcat cgctgctgcg attgaccttt tgaagcataa 1819141 tcccccataa agcttggaaa acagtgttta gtgtcgcacc agaagctgct gcgattttct 1819201 gtaattcggc ggtttctttt tcgggaatgg caaacgtgat ctgctgtagt gtcccattcg 1819261 gaatttgatc tgttcttttc ggcaggggtg tagatttttc gaaatgctga agcctctttt 1819321 tccagtactc agctgcttct tcacgatctt gctgcatcag ccatttaata tacgtcccgt 1819381 acggctgtac gggaggcaaa tcaggaagct ggcctttacc cagcgcttga taaatatgga 1819441 gaaagtcttt aatgacgatg cctaaacacc agccatccat taaaatatga tggtggctcc 1819501 agatacagac ataatgatca ggcgcccatt ttaaaataga tattctcatc agtacatccg 1819561 tttggagatc aaagcctttg gatttgtcct gctctttgaa tgcctcggta caatgttctt 1819621 tatccctttc attgagatgg gaaatatctt caatatgaat agggcaatga cgttgcttga 1819681 gcacgacttg acgaggtttg gctacatttt tatagatgaa tgctgttcga aagatatcgt 1819741 acctgtcaaa aacagcatcc atactttttt ggaaacgctc caagtcaagc tgtccatgga 1819801 tcgtaaaaga agcctgttca aaataagctc tcgactgttc atcatacagt gagtgaaaaa 1819861 gcatcccttc ctgcataaat gacaaagggt atatatcctg tatttcaggt tgctgcggca 1819921 tcagtgaatc tcctctccta tagtttgttg acggctccca tgatctcact caattcatca 1819981 agcgttaagt cttcatcagt gaaatcagat gcgctccact cttggttttc tttgccggta 1820041 caatgctcaa tgatgttttc cagagtctgt ttaaaatgcc tggaaaatgt ttggattgtt 1820101 ttttcctcaa attgaaacct gttatagatg atgtgcatgt tcaggcaccc cgaagaaacg 1820161 gcgccgctga tatccagtgc ataaggacgc tcccagttcg ggctgatctc atttcctggc 1820221 ttgatgtcag acacctcaaa ggcatttgat tgaatatcct gatcaaactg gcctaaataa 1820281 ttaaagctga tttctgggct gtttttctga gagccccatc ttttgctgat atatttcagc 1820341 acgccgtagc ccgcgccttt atgcggtata cggtgcagca tatcttttgt ctgtttaata 1820401 aggtggccca gccgctcttc tttgtcctta tgatcggaat ctctcatatc aagccacaca 1820461 ggataaatgg aggtgaacca gccaacagtt ctgctaatat cgatgtcctc aagatatgat 1820521 tcccttccat ggccctccat gctgatttta aattggttat ttcccgtcca tttctgcaaa 1820581 gcaagaccta aagctgtcag aaggatatca ttcatctccg tgctgtaagc tttatgtgca 1820641 gccgttaata gtaattctgt gtgatggcga gatagctcaa aatcaatcac ttctgtatct 1820701 ttgaatgtgt tagatgctgc gtcattgtct tttggaatag gctggatgtg acggttctcg 1820761 cactcatccc agtacgctgc ttcgcgctgc acctggcggc ttatagagta gtcagctatt 1820821 ctttgtgaat acgttaaata tgaatctgtt ttttgcggca gtttaataga ttctcctgag 1820881 actgcctgtt tgtaagctgt tgaaaaatcc tcaaacaaaa tgcgccaaga aaccgcatca 1820941 acaactaagt gatgaatcgt tagaaataaa tggtcaccat tctcggttct aaacaatcca 1821001 gcgtgaagta aggggccggt ttccaaacga atatgttctt gcatccggct ggctgcttcc 1821061 tcaatcgtgt tccgggcttc tgttaggcta tcctttacat caaacagttc aagtgcatat 1821121 agctcctcat ctgaaagatc tatccctctg tttatctgca cttgcctgcc atcttcatgc 1821181 cggcatacga ttctcagtgc atcatgatga gtcacaaggc tttttagtac ttttctaagc 1821241 gcagcctcat caaatcgttc agcccggtag atcataacgg attggttaaa atgatggctt 1821301 tccagagatt gcgagaaaaa ccactgctgg ataggtgtcc aagtaatctc gccttcgacc 1821361 gggccttggt caatggcgcg tacgtctttt cgaacccggg cggacagttc accaagagtc 1821421 tgatgttcaa acatctcacg tactgtcgtt tcaaatccgc gctgcttcag tctggcacaa 1821481 acctgcagcg ctttaataga gtctccgcca agcttaaaga aattggcgct tacacccagc 1821541 tcatctacat taagaagctc ttcccaaatt tcagccatca ccgtttcaat ctcatttcta 1821601 ggactgatat catcagctgt ataagcttgt ttttcaggct ctggcagggc tttctgatcg 1821661 agctttccat taacagtcac cgggatgctg tcaatttgta tcatacgggc aggcagcata 1821721 aagtcaggca aggcgttttt taggtaagtt cggatgtctg atatattcgc agcctgttga 1821781 tcttttatca ccatatatgc atatatagct gtttgccctt gctcgtctgc tctggtaatg 1821841 acagccgcct ctttaatcat tggatactga agaagtgccg cttggatttc gcctaactca 1821901 atacggtgcc ctctgacttt cacctgctca tcaatgcggc ctaagtattc cagctcgcca 1821961 tttgacaggc gcttagcaag atctcctgtt cggtataatc tgtctcccgg aagataagga 1822021 ttggatacaa aacggtcagc ggtcagctca tctctgttga gatatccccg tgccacacct 1822081 tcgccgccta tatacagctc ccctggaact ccggtcggct gcaggttcat atgggcatcc 1822141 atcacatgag cctgcagagt agaaagaggc cggccgatat tgcttttatt ttttgcaatg 1822201 tctgctgcgg acaatttttt gaatgttaca tggaccgttg tttctgtaat accgtacata 1822261 ttaatcaaat cagtatgagg atatttttca ttccagcttt gaagcaatcc gggctgtaag 1822321 gcttcgccgc caaaaatcac atagcggatg tttaaatgat ctgtatgatt ttggtcttca 1822381 agcatcaagc cgtaaaaagc agtcggggtc tgattgagta cagtgacgcg ctcttttttt 1822441 aacaataatc ggaatgcttg ggggtcacgg gctgtttctt tagagaccac gactaatgta 1822501 cttccgttca ataacgcacc gaacatctcc catacagaga aatcaaagca ataagaatga 1822561 aataacgtcc agacgtcttc atggttaaat tcaaaaggca ggttttgatg cttcaagaga 1822621 ctgatcacat tgcggtgctc gacaatgact ccctttggct gaccagtcgt tccagatgtg 1822681 tatatcacgt atgcgggctg atccgttact atttcttcaa tgtttacatc agccggaatt 1822741 gagttgtttt cacattcatc gatatacaaa atatgcccgg tgtagtctgc aggtttgttt 1822801 agaccgcgct ctgtcagcag cagttttgct ccgctgtcat tgagcataaa gctaatacgc 1822861 tccttgggat attcaggatc aatcggcaaa taggccccgc cagcttttaa aatcgataaa 1822921 acgccaatga tcatatcagg tgaccgatcg agcatcagac cgacgatatc gccagttctg 1822981 accccttgtt tgatcagcat agcagctgcc cgctcggctt tttcattcag gtctcgatac 1823041 gtaagctgag aatggccgca caccactgcg atatgctccg gatactgagc tacttgcttt 1823101 tcaaataagc ttactatgtt ttcatttctc ggataagctg catactgccc cattttttca 1823161 aggagtaacc tacgctctgc agcaggaagc aattgcatgt tcgaaattct catctcagta 1823221 tccgccgtta ccccttttac caattcaata aaataggatg cccactgcgt aatggtttct 1823281 tcttcaaaaa gagcagtgct gtattcaaaa cggcagcgta ttccactcag atgctcctca 1823341 gcatgtaatg ttaaatcgaa tttagatata tcatgtttag gagtgacaga cgaaatcgac 1823401 agaccaggca cttcgaaccg gaaatcttca ctgctttgaa gcacaagcat cgcatcgaac 1823461 agcgggttgc gatttacctc tcgatttgta tcgagcttat ctgccagctc ctcaaaagga 1823521 taatcctgat gctcgtaagc ggtcagagcc aggtggcgaa tgtcatgcaa ataggagctg 1823581 aacgttttgt ggccctcggg cttgctgcgc atcgccaatg tattgacgaa cattccgatg 1823641 acgcgctcca gatcagcgtg cggtcttccg gcagcaggcg aaccgacaac aatatcctct 1823701 tgcccgctta gcttagataa caaaatagaa tagacagcca gaagaatcat atacaatgtt 1823761 gttcccgttt cagccattaa acggtgcagt tcatcagcca tgtctttatc aatgttgact 1823821 tcaattgttc cacccctgaa atcagggaga cgcggccttg ttttatcaag cggtaattct 1823881 agtgtaggaa gactcccgcc aagctgaccg agccagtagg cctcctgttt tttgtatagc 1823941 tctttcgggt gcttctcttg ctgccaaaca gcaaaatcct tataatgcag gtttaaagct 1824001 ggcaactctt ttccgcaata taagtcagta aattcttgga caagagtgct catcgagaca 1824061 ccgtcggcaa taatatggtg catatcgagc agcaaaaagc cgcgattatt gcccattgta 1824121 atgacacatg ctctaaaaag cggaccggat gatagataaa acggtttgat aaaggtctcg 1824181 attgcagact caagcatttg ttctgattcc atttcaagct cttttagatc aaaagccatc 1824241 tctggataaa tgatctgcac aggctcgtct ctgtcaagca caaaaacagt ccgtaatgct 1824301 tcatgccgat tcacaagttc tgtgagaacg cttctcaacc gctggcgatt cagatttccg 1824361 cgtaattcaa gtacagctgg catgttgtag cctgtgctgt catctgccag ctgatgaaga 1824421 gcatataatc gtttttgcga gaaagacagc ggatagacat ctctttgatc cgcaggttca 1824481 atctgtgtaa aagcgtgttc ttttaagctc atcaatttga ccgccatgct ttcaaccgtc 1824541 ggataagaaa acacctcact gagcggcagc tcgacattaa gctttttatg tattcttgat 1824601 accagtgcgg ccgcttttaa ggactgtccg cctaactgaa agaaatcatc acgaatgccg 1824661 atgtgctgtt tattcagcac atcttcccaa atatgtgcga gatcagcttc gattaaggtt 1824721 cggggcgcca tatatgtgac actcgtattg ttttctggtt caggaagcgc aaacctgtca 1824781 agcttgccgc tggatgttaa tggcatctgg ctgatgttga taatacttgc tgggatcata 1824841 taggacggca atgtcccggc aagatgctga tacaaatctg ggaggctgtt tcccttttcc 1824901 ggaacgatat aagcaacgag ctccttttcc tcagcagaaa catcacgggc cagtaccgct 1824961 gcttctttta cccccggtgc ttgtcgaaga actgtttcaa tctctctcag ttcaatacga 1825021 taacccctaa ttttcacttg atcatcaaaa cgtccaatat attcaatcgt tccatcaggc 1825081 aaaaagcggc ctgcatcacc tgttcggtat aaacgctccc cttcaaggaa tggatgatcg 1825141 gagaatgctt tctgtgtcag ctcttgctgt ttgtagtatc ctctcgcaag acccgcgccg 1825201 gaaatacaca gttcacccgc cgcgccgatc ggctgcattt gatttccgtg caaaacaaat 1825261 acttttgtgt ttctgatcgg gtgtccgatc gtgatcctct cttttttatt cagatgccgc 1825321 aatattgttg ttgccacact gttttctgtg ggcccgtatt catttgccag ttcagcagaa 1825381 ggacaaatta tttgattcaa ctcaagcaga tcaggcgtga ccgcttcacc cgcaaatgtc 1825441 acaatacgaa gactttttgc atcgtcagca gtcatcactt ccaataacac cctgtacagg 1825501 gaaggaacaa tgatcatgtg gctgacctta taacgggcta tttttcgctt aagggccagc 1825561 acatccttcg cttcgtcatc tgttgtcagc agtacgcacg caccagataa aagcggggta 1825621 aataagctcg ttacacagcc gtcaaacacg tacgaaaaca aatggaggga tatatcctgt 1825681 tcggtcatgc tatactcttc ccgtctccat tgcaatgtat tggcaatacc gtgatgatca 1825741 actaaaaccc ctttagggcg ccccgtcgtt cccgacgtat agatcaagta ggctagatca 1825801 cctggcggca tatttggcgc ttctgtttgg taactttctg tatgttctat cgttatcgta 1825861 tttccttcat aggacggagg gatcaaggaa ataaggtctt cttctatcag caattgagcc 1825921 gcttgactgt ccttcagaag aaaagaaaga cgttctgctg gaaaatgtgg atcaagcggc 1825981 atataagcgc cgcctgcttt ccaaatccca agcagagctg caggcatttc cattgaccgg 1826041 cccatcatta cagcaacgat atccccagat ccaacgcctt tttctatcag ggcgtgcgca 1826101 atctgattgg ctcttacttg taactggcga taggtccagc actcgtttcc cattttcaat 1826161 gcagcagctt caggtgtttt gtgagcttgt tcctcaaaca attggggtat cgttttgttc 1826221 acataaggac gctcagtttc gttaaacaat tggataacct gttgctcctc cggcggcacg 1826281 atattgatgt cactgacggc aacatcggga tttgtcaaaa tgcaatccag tgcttgcttt 1826341 agatgcccct gaatcctcag catctcctcc cgctcgtaaa cgtctgcgtt gtagctgaat 1826401 ttgatataaa atgattctcc cggaacgata acgatattaa agtcgtaatt ggtttgttcc 1826461 gacattgaaa tgtcactcag cttcagagcg ccttcgtcat tttcactctc cacgcttaat 1826521 gcctgatgaa gctgtacagg gtaattttca aaaacaaaaa tatgatcgat caacccttgc 1826581 ttcaatggac tatggttttg aatctcataa agcggataat acccatgctg ttcagatgat 1826641 aaaatatcct cctgcacggc tttgaccagc gaagaaaatg ttatgccttc cgcagatcgg 1826701 attcgcactg gaacagtatt gataaacaaa ccgaccattg attcaatccc gtcaatcgct 1826761 gacgggcgtc ccgaaatgac ggagccaaaa acggcatcat ctgcagcatt atatcgatgg 1826821 agcagcacgc cccaaatact cataaacagc gtgtttaatg tcactcccca gttttgggca 1826881 gcctctgtca gtttctcaac catatccggc gctaatgaaa agctgacctg gtcggcttta 1826941 taattcccgt ctgccgtgcg gcgctttatt cggggaatag aagcagtatt gccgtactcc 1827001 ttcaaatatt cgctccagta ggcagcagtc tcttcttgat cttgttctcc gagccattca 1827061 atataacggc tgtacggcac cgtgctgcca agctgtacag gtgagttatt tttgagcgaa 1827121 tcatacatgc tgaaaaactc tttaagaata atgccgagac accacccatc catgatgata 1827181 tggtgatgtg tccagacaca tgtatattgg ctgtctcctc tatcaaaaag ggcaagacgc 1827241 attaaaggat ctttttgcaa atcaaatcct ttttcccgat ccttagtcat aaaagcatca 1827301 atcagcgtct gctgttcttg atcagccagg cgagaaatat cttctctata tactgtcaat 1827361 tcacggtttg atagaactac ctgctgcgga cctgtaagat ctggtacttc tttaatgaaa 1827421 atcgttctga aaatatcata tctagaaaca agaaggttta agctcttttg aaacgagtcg 1827481 acgcatagat tccctgtgat cgtaaacgag gtctgttcga tatatgcttt cgagctgaaa 1827541 tccattagtg aatgaaacag cattccttcc tgcatgtgcg ataacggata aatatcttga 1827601 atttgtgccg attgtgccat caattccaca caccttttca aaagttaaag atctttcacg 1827661 agatcttcga tgctagataa tgcagacaac gttaattctt tattgctgaa atcgctcaat 1827721 gttttttcgc gtgctttttt ctgcgaacaa tgctcaatcg tctcgataag atgcctgtga 1827781 aaacgatcca taaagcactc aattgagtgt ttgctgaaca cttgggtgta taccgctttt 1827841 acgtgaagcc gtccgtccgt aatgagagca ttgatgtcca gctcatactc tcgttctctc 1827901 tcacccgcta tttcgtaacg gggctggtaa tatgataatt gaaacgtttc aacttccttc 1827961 tcttcgctaa attgaccgag ataattaaag ctgacctcag gctctttatg ccgcagttct 1828021 cctatgtgtg ttaacaatcc gtatccagtt cctttgttcg gtactcttct cagcatatct 1828081 tttgtcgtct taattcggta tgcgagctga tcctcgaaag gctcgggaat acccatgtct 1828141 agcagaatag gataaatgga ggtaaaccat ccaactgtcc ttgaaatatc aatgtttggc 1828201 acatgccctt ctctaccgtg tccctcagtg ctgatcacga tttggtcatg cccagtccat 1828261 tcagaaagcg ccattcctaa agccgtaagc aaaagttcgt tggcatcagt accataggct 1828321 tgctgggttt caaacagcaa tttttcagtc cagtccccgg atagtacaaa cgctgctgcg 1828381 tcgctgttca tttggagttt gtctggcaca ttttctatgt ccttaggaag aaaagcagtg 1828441 tgagcgtcta aaatcgtttg ccaatacgtt ttctctgaaa gcaattgttt actttcagct 1828501 atttgggtaa gaccatcggc gtaggataaa taagaatccg tttttggcgg taattggatt 1828561 tctttctttt ctaaagcctg ttgatatgct gcagctaaat cctcaagcag aattctccaa 1828621 gaaacgccat ctatcacaag atgatgaagt gcaatcagca aatgatcccc ttctgccgtt 1828681 ttaaacaaac ctgcttgcag taagggccct ttttctacat tcattttgct ttgaatgacg 1828741 gtttcctcag cggcaagttt ttcatcaaga tgagcccttt ccagcgatgc ttttgtccaa 1828801 tctgaaatat aaaggccaaa cagttcatga tccttgtgat tgattccgcg attaaactga 1828861 atgacatggc cgttttggtc acgttggaaa atcatgcgaa tggcatcatg atgctcggtt 1828921 attttacgca gcgctagatg aagcgcgtta gcattgaatc ctttttcact gaaaagcatg 1828981 acggactggt tgtaatgata gtgaaaagca tgtacctgtc cgaaaaatct tcgctgaatc 1829041 ggggtgagtt cagcttcacc ttccgcaggt ccctggtccg cttgagatgc caatggtgtg 1829101 atatgtccgc atagttcctg aatcgttgaa taacggaata agtcgcgtat tgtcatgctc 1829161 cagccttcag ctgccagacg tgctgccact tgtaatgctt taattgagtc tccgccaagc 1829221 tcaaaaaagg aatcgtgaat gccgactcgt gacatgctca gtacatcttc ccatatatac 1829281 gccatcgttt tttgtaagtc gttaactggt gcggtatatg gacgcgataa cacattattt 1829341 ggagccggca aggcatttct gtccagcttt ccgtttaggg tcagcggcat gtttactaaa 1829401 ggaatcagat atgcaggaat catatacgct ggcagttcct ttgttaaagc agcacggaga 1829461 gcattcgtat tgacgtctga aggcacaata tatgctgcca aaccagcctg tccattttta 1829521 tcatgctgaa cggcaacagc agcttctctg acaagccccg tttgaagcag aacactttca 1829581 atttcttctg tttcaattct gtatccattt atctttactt gataatccat tcggccaaga 1829641 agccggatcg ttccgtttgg aagccagcat gctcgatcac cggttctgta cagcctttct 1829701 ccagagacaa atggattttc tgtaaatttc atttgcgtta agtcaggttt atgatgatag 1829761 cctttcgcaa cacctgcccc gccgatgcac agctcgccgg caacaccgat cggctgaatt 1829821 tgatcagtct ggctgagtac gtacatgtgt acattcggca gcgggctgcc gattggtacg 1829881 ttatctcccg tacactctcc acccatactg gtttcataga aactcgaatc aatggttgcc 1829941 tctgtgacac catagctatt aatgatgcgc atgctttggc caaagcgatc tgtcaatgtt 1830001 ttgaaatctt gagctttcac catgtcggaa ccaagaatca gtatgtctaa gtcaggaagc 1830061 ttgaactggt tacggtatac atactccatc accgggataa tgagagccgg tgtcgactcc 1830121 atcaccgtga ttctctgaga tttaatgatt ttatatattt cagcaggttc cagccgtgtt 1830181 tcatctgggc aaacgattag agtcccgccg ttggtcaatg ttctcgccaa atctcctgag 1830241 aagacatcga atgaaaagct cgcgatttga agcagtctga caggcttccg atccagttca 1830301 taaatttgac gccaagcaag agcagcatga gtaaagttct gataggtgac aataacacct 1830361 ttaggcgcac ccgtcgttcc tgacgtataa atgatatata ccggctcttc aggagcagga 1830421 gataagttaa ggttgcagtt actttcttca aaagagccct catcgtcaag gaagatgtga 1830481 gacatctcag attcaggcga gttcgaaatc aaatgcttca actctctctg taaaagaaga 1830541 atatctgccc cgctatcacg aagaatgtat tcaatacgag cttttggata atgtgcatcg 1830601 attgggatat acactccgcc agctttcatc actgccagaa ctccaacaat tgcatcgatg 1830661 gaccgcttgg ctaaaacagc cacagttggc ttcggtcctt ttctgttttg caatgttcgt 1830721 gccagacgat tggctctttc atttagaagg cgatagctaa tctctgtttc gttatcaata 1830781 acagctatat gttctggatt ttcttcagct ttcgcttcaa atatgcgatg aaaaggaata 1830841 tctttttgag caaattcaac ttgagttttg ttaaattcaa agactatttt ttgtttttct 1830901 ttatcactaa gtatgtttat ttgtgcaagg cttgtttcag gagttgaaag tgcctcatgc 1830961 agaaattcga taaaatgatc agcccagcgt tcaatcgtag ctttcaggaa tacttctgta 1831021 ctaaattcca tttcgcagca aatagatcca cttatttccg tagctattaa tgtgatatca 1831081 aataaggaaa tgtgatgtgc gaaattggca ggccggactt ttatttctct cagatctatg 1831141 tcttgttttt ccacattttg aaggataaac atcgcatcaa acactgggtt ccggctcata 1831201 tctcgtgtca attcaagctt atcgacaagc tcttcgaacg ggtaatcctg gtgctcaaag 1831261 gcttccaatg ctgtctcacg cacttcctgc aaatactgta cgaatggctt cccgccctcc 1831321 gggcgcgtcc gaagcgccag cgtgttcaca aacatgccga gtatcggctc aagatccttg 1831381 tgcggccggc cggcaattgg cgagccgacg atgatatctt cctgtccgct taagcgtgac 1831441 aagaacgcgg tgtaagccgc aagaagcacc atgtacagtg tgcttccgtt ttcacgtgcc 1831501 agcttgtgaa ggcctgatgc aacctcttga tccagcgtaa atgagacctt gtcacccgcg 1831561 aagcttcgca ccggcgggcg ggcatgatca gccggaagat ccagcacagg cagctcgccc 1831621 tcgagctgct tcagccagta cgcctcttgc gttttgtacg cgtctcctgt tttgaatcct 1831681 tctcgccata cggcataatc tttatattga atgcgcagtg ccggaagatt ccgattattg 1831741 tacagctcgc cgaattcccg aatcagaatg ttgacggaaa caccgtctga aatgatgtga 1831801 tgcatatcaa ccagcaacag gtgccgctca tctgatatct ttacgatttg ggcacggaac 1831861 agcggcgctt ggctgagatc aaacggtttg ataaatgcgg ctgcggcctc ctgttcggtt 1831921 cgttcgccga gaactgtagt ctgtaacgta aacggcacct cgtcatggat gcgctgcacc 1831981 ggatcgcctc ctgcgtcctg ttcgaaggag gtccgaagcg actcgtggcg cttgatcagc 1832041 tctttgaaag ctctctccat cctttcaggg ttgagcttcc cttcgagctc taacacagcc 1832101 ggcatattgt agcctgtccc tccgtcctcc agctgctgaa ggacataaat ccgcttttgg 1832161 gcagaggaaa ccggataggt ttcctgtttt tcagcgggct taatcgcttc atatggactg 1832221 tccgttcctt cacggataac ggtagccagt ccttctactg tcggatgggc aaacacatct 1832281 tttagcggca cctgtacatc gaattctttg gcgatccgtg agacaagcgc cgttgctttt 1832341 aaggaatgtc ccccgcggtc aaaaaagttg tcgtgaatcc cgacagggcc atttttcagc 1832401 acgtcctccc acagctgaga aagcttcatc tcagtcacgt ttctcggcgc cgtgtaggtc 1832461 tccgcatctg ccgctccgcc aggagctggc agggcgtttc ggtcgagctt tccgcttggc 1832521 gtaaccggcc actgttccat ctctatcata taggctggga ccatgtagcc cggcaacagt 1832581 ctctcaagct gtgcacgcac ttcgtttctt tggagccctt ctacataagc gcataattcc 1832641 ggctccccgc tgtctgtccg tacggtaaca gccgcctctc ttacgccttc tatgcttctt 1832701 agtgccgctt caatttctcc cggctcaatc cggtagccgc ggatttttac ctgatcatcc 1832761 gtgcgcccga ggaattcaac attcccgtca gggagccagc gcgccacatc cccggttttg 1832821 tacatgcgtt cccccgggta aaacgggtct tcaagaaaac gctcctccgt taatgccggc 1832881 cgattcaaat aacctctggc aacacccgct ccggcaatgt acagttcgcc ggcgacaccg 1832941 gaaggctgta cggctaaatg cggatctaaa acatacaaac gcgcaccagg tacgggcttc 1833001 ccaatcggaa tccgcaaacg atccctgtcc cgttctggat ccaatacgta aaatgccgcg 1833061 tctaccgttg cttctgtcgg cccgtaacca tggattaatg atacctgcgg caatacagaa 1833121 gcaaaacggg ctgccgtacg cggcgcaagc ggttcacctc cggcgaatac acgctttagg 1833181 cttgtcctgt cactcagcct ttcgatttcc gcttgatcga gaaagctgtt cagcatagcc 1833241 ggaataaaat gagccgttgt cacgttttcc tgatgaatgg cttgtacgat caatgcggag 1833301 tctttctccc agccgggcgg aagcagatac gccgaagcac cggaaagcga ccaccaaaac 1833361 agctgccaca cagacgcatc aaaggaaaaa gaggttttca ccatgacaat gtcatcttcc 1833421 gaaagcggaa actggtgctg catgccggtc agaaaggaaa cagcctgacg gtgctcaacg 1833481 gccactcctt tcggctgccc ggtagagccc gatgtataga tgacataggc gagagatccg 1833541 ccgtcagcag gagtaaactc atggttttct gctttttcgc tcgcaagaga tgtcatgtcc 1833601 acttcaagcg tttcgccaga aaagtttggt gcggagcatc ccggctgtgt cagcaagagc 1833661 gatgccccgc tgtctttcag catgtagctc agccgctcct ttggatacgc aggatcaagc 1833721 ggcaaatacg ccccgccggc cttcaataca gcaaggacag cgatcagcat gtcaggtgag 1833781 cgttcagaca ggacaccgac gatactttcg tttgtgacgc cgcgtgccgc aaggtgcgca 1833841 gccagccggc tggcgtacat atcaagctca gcgtatgtca gcgaaccgcc tgaaaagcga 1833901 atggccagcc gctccggtgt gaaagctgcc tgtcgctcaa acagcccatg cagggtgaaa 1833961 gctttaggcg aaacagcttc cgtcttgtta aactcataca acaatttttg cttttctctt 1834021 gtattcgtca tatctaattc tcttataaag ctgtgcggat gtttaagggc gttttccagt 1834081 atggtaagca gatgagattg tattcgttta atatcctcaa gagaaaacaa ggtattttga 1834141 tagtcgaaat ttaattgaat ggttccattg tctatccgtt cttgtatttg aactgaaagt 1834201 tcgttcgcgg tgtatccgct gaaataaagc gctgtttcat agtcaaaatc atctgcattg 1834261 tgccactgaa gtggctgata ctgcatagat ataccgataa ggttgtgtaa atccttctgt 1834321 tcatttctta attcatttac aagcaaatta taaggaaacc gttgatgacg cataacagaa 1834381 agctgttccc tgcctattgt gcggacaaag gaaagaaaat ctgtgtcagg atcaaccgtt 1834441 attctgattg gaagggaact aacgaacatg ccgagcattt ctttttcagc ctttgaacct 1834501 ctgttgccat agtaggtgcc aatggcaaga tcttttttag aagtgattcg gctgatgcat 1834561 atgtaaaatg aagccataaa taaggaaatg atattgatct tgtgttcttc gcagaagatt 1834621 cgaatcgttt gctctagatc aggtgaaaga atgatggtgt ctctggatgc agatgtgctc 1834681 tgtttttgta aggacgtctg gtcggctaac gagtggtatt ccaacgggtg ctcaaaggtt 1834741 tgcgtccaaa ataaacggtc ctttgcaaac cgtggagatt gtagatattg actctctttt 1834801 tcgatgtagc tcaagtaaga aggttccggc tgatcaggta aaggatcttt ctttttcatt 1834861 ttttgataaa gatctataat ttgatttccc atcacattta aagagattcc atccattatg 1834921 atatgatgga atttcgcaaa tagccaaact tcatgagagt caattctaag gaggtaaaat 1834981 tgaaaaagag gcgagttgaa cagtttaaat ggaatgctcg cttgatcctg aatccattgc 1835041 tctatttcta tcatttcaac atttgaaaaa tcaattattc taagtggata atatttatat 1835101 tcagtaaggt gcaatcgagg ctcaagctct tctccttcta acagctgaaa tctaatggcg 1835161 tcgttgcggg agatggaatg attcagtgct ccctccagag tatcaagctc aatattgcct 1835221 ttaaatttca cacaagctgt aagattgcaa atgctggtat ctggctccag cagttcggta 1835281 aaccacactc tcctttgggc atgggttaaa gaataagtat gttcgctcaa cggattccct 1835341 ccagttctca taataagagg ataagaaaat gtagaaaaaa gcagaaaaat gacaataaaa 1835401 gaaattatat gactatataa tccatatatg cactatatta acggatattt tttaaagtac 1835461 aataaaaaac attaaatttt tataacattt tttttgaata tagtattatt tctttatttt 1835521 tcgtttcttt ttttatcaaa tttccggata taaagtgata aaagtattgt tttacataag 1835581 gtcttataca ctacttttta atcggactaa ttttcttttg tgcatcattc ttctaattgt 1835641 tggaaggttc gacaaagcgt tattacagac ataaaaaaac ctgttttctc ttggaaaaca 1835701 ggtctcccgc tattattgat ttgccaaaat gacagcgatt tgatcctcaa tatcttttcc 1835761 atcctcttca tcaatcaatc catttagaag aatagagaaa acaagttttt ttccgctctt 1835821 tgtttctgcg taccccgata gagagcttac cgtactgagc gatccggttt ttgctcttac 1835881 ttttccttgt gcaggagtgc ctttcatgcg gtttctcagc gttccgccca ccattctgtc 1835941 aggattcccc gcaacaggta aagaatttag ataagccgag aaccaactct gatcctgaat 1836001 gtcatataac agctgtgaaa gttgatctga ggatacagca tcaatatgtg agattcctga 1836061 tccgtccctt aagacgagtg atttagaatc aacaccaaat tccggaagcg tactgtttaa 1836121 cacttcgagc cccttttccc agctcccttc tccttttttc actttcccca tctcttttac 1836181 gagcacttcg gcatgtccgt tattacttaa tttcatgaac ggcacaaaaa gtttcgataa 1836241 aggcattgag cgatgagaga gcagcacatc tgaagaacta ggtgcttcac ccgtcttgat 1836301 gtcccctttc acagtaatac cttgtttttt tagtgactgc ttaaataaat ctaaggcata 1836361 tccggcaggc tcccagacag aaatccattc ctttgtcttg tttgcgtcaa ccggtacgct 1836421 cccttcaatt gtaatcgtgt ttgttccatg ctctctttcg attgtgaggt ctttctctga 1836481 accggcagca gtcgttttag catcgttctt tatcgttata taatcggttt tcggagagac 1836541 agacacggca ggctcttccc cttctttttg atttggggtg acctcaacaa tcacagtgcc 1836601 tgcatcatag tcttcgtttg gagacgctgt tagagcggag attggcgcgc cataatatgt 1836661 gtattcatcg ctccaaggca tatcaggtga taatcgcatg tcatcatgcc acgtatcatc 1836721 accgatcaga ttgcctttaa ttacttttac gccggaatgt ttcaatatct cagccatttt 1836781 gtcaaaatca gatggtaaaa gtgtcggatc gcctttccct ttcaaataaa ggttaccatt 1836841 cagctttttc cctttcagtg ttccatccgt ccggacctcg gttgtaaaag aatagttctc 1836901 gccaaggaca gaaagtgccg cggccgctgt caaaagcttt agagaagagg caggcctcat 1836961 tcgggtgtct cctgaatgtt catatagaac agcacctgtt tccgcagagc gaacggtgat 1837021 gccggccatt gcgccttcga gggcaggatg atcagctaaa atcttatcga tctgcccgga 1837081 aagtgcatct tgtttttcag cggcaagcgc agcctgatgc atataaggca ccgaagcaac 1837141 gacgaaaagc agtaaaacag caacataaag ctttatgctt tttttcatta atttccccgc 1837201 ctctctgcgc ttcatcattg gctattgatg attcagttca atggtgatac tgcttttagc 1837261 tgtcgtttct tctcccggct ccagcacttg taaaccagtg agtgacgaag gtaaatcaag 1837321 attcactgcg tttgtcaccc atgtgtaagg ctcagggcat aaataccctt gttttccgtc 1837381 cgcattgtat acaacccaat gtttaaactg ttcatctgcc ttataaataa tgctgatatg 1837441 tgcatgctga tgataaatga ctgcctggtt ttctccgccc ctcttctgat aagaagataa 1837501 aaagacatca tccagctgct tgtggcgcaa atccattcct tcatgcaaag cttctttata 1837561 cgggacatcc atcagcttcc cggtcggcag caggcgttca tccaactccc attgctgatc 1837621 tgctgtcagg gagaataacg agctttctgc cggaaatata aatgtagtat gataaccaat 1837681 tccccaagga aacgcttcct ttcctttgtt catgaccgtc gcatgtttaa atagggtatt 1837741 ctccttgatc gtgtatgtca tccgaacgac ggcatgatga ggaaattgct tctgcacatg 1837801 gggaagctca gaaagatcaa tttctgtttc aacaatcact ccttcatcag tttgcttcgt 1837861 ggtcacgaca ttccactttt catggtaaag aaacccgtga agatggttgt gtttatcctt 1837921 ctcgttgata tcaaaatgat acgttctgcc ccggaaactg aatgtaccgt cacttatgcg 1837981 gttaggcggg aacaggattg gaatgccata caatgttggt gtgtcgtgaa aactttctgc 1838041 tgtttccggt tcacgcaaaa gctggacatt tgttgttttg tccacgagag aaatgacgtt 1838101 gctcccccac tcagggacaa caatcatttc tagatgttcg ttgcccgctt tgatggccgg 1838161 cgttcccaaa tacgtgattt tctcaataaa gtttgccatg tttactcaac ctctccttga 1838221 ttcattgcta gtataagaat tcaatgtact gtaccatatt tcctccattt tatattttcc 1838281 cctatcaaat aaaaaaacac cgttcaaact tatgaacggt gtgattcgga ggctattgga 1838341 tgagacgtgt gatttgtttc tttttccaga cgaattgata atacccataa atcaacagca 1838401 agctgacggc aaacgcagct ggataaccaa cccagacgcc gagtatttca agctttgtat 1838461 agtgagaaag gacgaaagcg acaggcacct ctactcccca gattgcaaaa atactgatga 1838521 cggtcggcca taaaactgtt ccgcttgccc gcatcgttgc agaaataatt tgggcatttc 1838581 caaacagcaa atagctccac agtgtaatca tcaaaagacg gtgcgcaatg taaagcgtct 1838641 cttgctcggt taaaaataac gataaaatct gatgtgaaaa aacatagatc agaatgatca 1838701 gtacgccgcc aatgatataa ttcagccaaa tcccaacgcg aatgacctgc tttaagcggt 1838761 caaactcgtt tgctccgatc gattgcgcag cgaaaataga aaccgcaata ccaaggctga 1838821 cggccggcat ctgtacatag ctggccacct ggttgaccac tccgtatgca gctgttgcat 1838881 tagagccgta atgattgacg aatgaaataa ccgctatctc tgataatgag acaagaatca 1838941 tattgatgct tgctgggacc ccaagacgca gcaggagaac cagcagttcc ttatccattt 1839001 tcaaataacg acgcactgtt ttatcaaatt gcagcgggtg ttttcgcttt cgtaaataca 1839061 ccattaacac gagaaaagtc gcaatcgtgg aaatgacagt tgcatatgcc gagccgtata 1839121 tgcccagttt cggaaaacca aacatgccaa ggattaaaac aggcaaaagc gcgatgttga 1839181 tgaccgtgct cacaatcagc gtataaaacg gtgtcttgga atctcctgtt ccgcgcaaaa 1839241 aggtagtata tgcaaaatat aaaaacataa acggcatagc ataaaataaa atacgtgcat 1839301 agttagcgct gacatgaatg acattttcag gtgttcccat taaacgaagg atatccaggg 1839361 tgaaaatact gccgataacg gctaacacaa cgcctaataa aaatgtaaac gtgagtgtcg 1839421 tcccgacaac agcctttagc cgttcctcat ttttcgctcc gtaagcttgt cctatcagaa 1839481 tcgaacttcc tgaaccgatc ccaatcgtaa atgagattaa aagaaaaaat aacgggaaaa 1839541 aggatgatac agctgccact gcatcaacac cgagccatct gcctacagcc atcatcccga 1839601 ctagctggcc gactgattgc agcacattgc tcagcagaag cggcactaaa aagagtgaca 1839661 tcgaccgcca aactgatggt ttgcttttct tttgagttac aagaggttct tgtgatgttt 1839721 ccatattaaa ggactccttt atttgaaatc gtttttaaac atgccctcat tttttgacaa 1839781 aaacaggata tgtaacatgt tattattcat cactgcactt atgaaaccct tcccgattct 1839841 tctaatttta cacatctttt tagcttatga agaataaact agcaagtaat ggcgtatttt 1839901 ttgtgagtaa aagaataaaa aataatttat gcaaaagtat tgtaatctat ccgtaattat 1839961 tgtaacattt gtaacataag agaaagagat tttgaaggag agagcgataa tgaaaaaatg 1840021 tcttctattt ctaacaacca ttgcacttat tctgtcatta agcacaaatg catttgcgaa 1840081 aaatacatca ggcgatttat cacaaaaaca agcattacag ttggcattat ccgctagaga 1840141 acatttttgg aacaccatga gcggccacaa tccgaaggtg aaaaaagcag tttgcccatc 1840201 aggcacattc gagtatcaaa atcttcaata tgtatacatg tgcagtgatc taggcactaa 1840261 agcaaaagcg gtgaattatt taactcctat ttttacaaaa acagcaatcg aaaaaggctt 1840321 taaagattat catttcactg tttcaaaagg aaaacttgct gttccaatcg gtgacggaga 1840381 caatcttttg aattggaaaa aatcaactgc taaactgatc tctaaaaaag gcagcacaat 1840441 cacatacgaa tttactgtcc ctacattaga cggatcccct tctgcaaaac ggaaagtgac 1840501 atttgtgaaa gaaaataaaa aatggaaagt caatcaattt gacgcagtta tataagaaaa 1840561 acgcccggta taagcgggcg ttttttattt ggtttgcata aagaaagaca acaggcgaaa 1840621 agtgcctgtt gtctttttgt gaatataacg ctctaggaga gattcgaact cccgacctgc 1840681 agtttaggaa actgctgcac tatccgctgt gctactagag cttttggtat ttatatagta 1840741 gctctgatga tcaatatttt caagcgattt gtattaaagc cctccaaaaa ccttatatgc 1840801 ggctcttgtc gtatcttcat caataccgat ataccgcatt gtaattgatg gtgatgaatg 1840861 attcagtatt ctctgcagct cggcgatgtc tttcgttcgc tgataaaaat gatagccaaa 1840921 cgttttccgg agtgtatgcg tccctatctc ctcaagtccg cacgctgcag cggcctctct 1840981 taaaattctg taggcctgaa tgcgggaaat cggcttcctg gtccgcactg atttaaaaag 1841041 atattcgttt tccttcatgt ctttcgtata ctcgtatatt tcctgtttca gcgattctaa 1841101 aataagaatc tttcttttct ttttcgtttt gctttcagtc gcccataaat gatctttatt 1841161 ttgaacgtcc ttcacttgca gcggcagaat atcagaaata cggagcgcgc tgttgatgcc 1841221 gaaaataaac agaaaataat cccgcttgtt tttgttaagc aaatactgtt tgacttcttg 1841281 gattttctct agactgcgaa tcggctgtac aatatgcatc aaaaaactcc ttaaaaaccg 1841341 ttatgtaaca ttttgaggtc tatgttacta ttatagctga aaaacgttga atgtcaaagt 1841401 gcggcggcgt ttatgtaaca taatatacat agtgttacat aagcttttaa aaaagcttct 1841461 tccaaccttc accctataaa ataagcttta aagcctctta taaagctttt aacctcttgg 1841521 atacttatcc ccctactaat catcaaaaaa cctcttaaaa tgaaatctga cactcccaat 1841581 tttctggagc ttccgcaaaa atatacaaaa aaagacacaa tttcaaattg tgtcctaatc 1841641 ctcatccttt acatcaatat cttccgggat cggttcattt aatatttcct gcacaagtgc 1841701 tttgtaattc tccagctgtt cgagatgcgt tttgaactgt tccttataaa tcaaaaattg 1841761 ctccccgtca tgaacggctc tgattttccc ttcgagcacc aagcttttaa tataatcctc 1841821 tgaaagattt gtatattctg ctgtttcttc aatcgttaaa tacatatagc agtcccttct 1841881 taatccgtat gctgattcta atatagcaca tggctcatat caatataatc aattctgcac 1841941 agaaaaacgg cattatgcac tatataatat accatttgtc acttgtgaaa acgctgtaat 1842001 ttttttacgc taagattgta acaatacagc ttcatatagg agggagaaca tgaaaagaac 1842061 gtggaacgtc tgtttaacag ctctgcttag tgttctgtta gtcgctggaa gtgtcccttt 1842121 tcacgcggaa gctaaaaaac cgcccaaaag ctacgatgag tacaaacaag tagatgttgg 1842181 aaaagacggc atggttgcga ccgcacatcc tcttgcttct gaaatcggtg ctgatgtgct 1842241 gaaaaaagga ggaaatgcta ttgacgcagc ggttgccatt caatttgcac tcaatgtaac 1842301 agagccgatg atgtcaggta ttggcggcgg cggttttatg atggtgtatg acggaaaaac 1842361 gaaggataca acgataatcg acagccgtga gcgtgctcca gcaggcgcaa ctcctgatat 1842421 gtttctggac gaaaacggca aagcaattcc tttctctgaa cgtgtaacaa aaggtactgc 1842481 cgttggtgtt ccaggcactc tgaaagggct ggaagaagcc ttggataaat ggggaacccg 1842541 ttcgatgaag caattaatta ccccttctat taaactcgct gaaaaaggct ttccgattga 1842601 ttcggtgttg gcagaggcca tttctgatta tcaggaaaag ctttcacgga ctgccgcaaa 1842661 agatgtattt ttaccaaatg gcgaaccgct taaagaagga gataccctta ttcaaaagga 1842721 tttggctaaa acatttaagc ttattcgctc caaaggcact gacgcttttt ataaaggaaa 1842781 attcgccaag acgctttctg acactgtcca ggatttcggc ggatcaatga cagaaaaaga 1842841 tttagaaaat tacgacatta caattgatga accgatttgg ggagattatc aaggctatca 1842901 aatcgctact actcctcctc caagctccgg cggtattttc ttattgcaaa tgctgaaaat 1842961 ccttgatcat tttaaccttt cacaatacga tgtccgctca tgggaaaaat atcagctgct 1843021 tgctgaaacg atgcatttgt catatgccga ccgtgcgtct tacgcaggtg atcccgaatt 1843081 tgtaaatgtt cctctcaaag gcctgcttca ccccgattat attaaagaac gccagcaatt 1843141 aatcaaccta gatcaagtga ataaaaaacc gaaagccggt gacccttgga aataccaaga 1843201 aggatcagca aactataaac aagttgaaca gccgaaagac aaagtagaag gccaaacaac 1843261 ccactttaca gttgctgacc gttggggaaa tgttgtttct tatacaacaa caatcgaaca 1843321 gctattcgga acgggtatta tggtccctga ttacggtgtt attttaaaca atgaattaac 1843381 ggattttgat gcgataccag gcggagctaa cgaagtacag ccaaacaaac ggcctttaag 1843441 cagcatgacc ccgacgattt tatttaagga tgacaagcct gtcctcacgg ttggatctcc 1843501 tggcggggcc acaattattt catccgtttt gcaaaccatt ctctaccaca ttgaatatgg 1843561 tatggaatta aaagcagctg ttgaagagcc gagaatttac acaaacagca tgagctctta 1843621 ccgttacgaa gacggagttc ctaaagatgt cctcagcaag ctaaacggca tgggccacaa 1843681 attcggcaca agtccggtgg atatcggaaa cgtgcaaagt atatcgatcg accatgaaaa 1843741 cggcaccttt aaaggtgtag ctgattcaag cagaaacggc gcggcgatcg gcattaattt 1843801 aaaacgtaaa taaataaaaa actgtactcg cttcaaatga gtacagtttt ttcatgcaga 1843861 tctttaaaat aaaaactgac aaacgtcttt attctgctaa tgcacgtcta tcttcatctt 1843921 ttcatttcgt ttatctcatc aagaaatgtc tgaaacgcac tcgtaataaa aaagtctttc 1843981 ctgtatataa agacgatctc taagtcttga tatgatggtg gcagctgatg aatccataca 1844041 tttgtacgat gctcggagcc gtcaacagcg gactttggga gcagcgccgt acccatcccg 1844101 gcggaaacac cttttataat agcctccaat gtgccaaact ctatgatttt ttgattgtgt 1844161 atgcctgctt cctctagtaa tcttttgacc ctgtcacgat gagaacagcc agccccaaaa 1844221 aagagcatcg gctgctgaag catgtcttct gccgtccctt ctcgtgatga aatcaaaact 1844281 aattcatcat gggagacatg gagttgtcta actgcagcgt gttcaaccgg cccatataca 1844341 aaagcgccat caactttatg atcaagaacc tgttgaatca aatgatgcgt atcagctgtg 1844401 ttcactgata aatccacttc aggaaaacgc ctgaggaagg atgctgcatg ctcaggcaga 1844461 tgcgttaccg ccattgtttc cagtgatccg atccgcaaag gcccttttgg ttgcctgctc 1844521 attcgggtcg atttttcagc ttggtctaac agcgataata cttgatctgc atattgtaaa 1844581 agattttctc ctgcagcagt cagcttcatt ccccgattcg ttcgatgaaa aagcctgata 1844641 ttcaaatctt cctcaaggtt atgcactctg gctgtcacat tcgactgaac ataattcagc 1844701 atttgggctg ctttcgttat gcttccttcg cgagcaacag cctgaaaaat ctttaaatct 1844761 ccgctttcca cgcgctctca cctgcttgct atgatgaaaa gtgatattgg ctatcatatt 1844821 tgttcatttt actcgaagaa aaccgctatg taaaatatgt aaagatatga aaatacaatt 1844881 aatgaggagg cagacagcat gaaagctgta attcacaacg gaaaagccgg tcttctgggg 1844941 ttatcagttc aggacgttcc atcaacaaag cctggatacg gagaggtaaa ggttaaatta 1845001 aaatctgcag gcctgaatca tcgtgacttg tttcttatga aaaacaaatc tgaacaagat 1845061 cctcacatga tactgggttc tgacggcgcg ggtatcatcg aagagattgg tgaaggcgtg 1845121 aaaaatgtta ctgttcagac agaagtagtc attttcccga cattgaactg ggatttgaca 1845181 gaaaatgttc cacctgtacc tgagattctg ggaggtcctt cggacggaac acttgctgaa 1845241 tatgtgatca ttccttcaca aaatgcaatc aaaaaacctg cttatttatc ttgggaagaa 1845301 gcgggcgttt tacctttatc cgctttaact gcatatcggg ctctgtttac aaaggggcaa 1845361 ttaaaaaaag gcgagcatct attgataccc ggcatcggca gcggtgtagc aacctacgct 1845421 ttatttatgg ctaaggcgat tggggcaaca gtaagcgtga cctcccgcag tgaggagaaa 1845481 agaaaaaagg cgctgaaatt aggtgctgat tacgcatttg acagctacag caattgggat 1845541 gagcagttgc agggaaaaaa gatagatgtt gttcttgaca gcataggacc tgccctcttt 1845601 tcggaatact tccgccatgt aaaaccaaat ggccgtattg tcagctttgg ggcaagctca 1845661 ggggataatc tcagttttcc ggtgcgttct ttattctttc ctcaggtcaa tgttttggga 1845721 acctcgatgg gaagcggtga ggaatttcaa gctatgctcg ctttcattga caaacataag 1845781 ctgcggcctg taattgaccg gatatatcct ttagaaaaag catgtgaagc atataaaaga 1845841 atgcaggaag gcagacagtt tggaaacatc gggatcgtaa tggaataaaa aaagaaaccg 1845901 gctggcagcc agaccggttt ctcttatatg ataatcccct ttatttacgg aagaactgaa 1845961 ctccccatca aatatcgatc cacttcacgc gccacttcac ggccttcatt aatcgcccat 1846021 acgattaagc tttgccctct tcttgcatcc cctgcggcga atacaccatc gatatttgtt 1846081 tgataatccc catatgctgc actgattttg ttatttactg aattaacacc gaactgtttc 1846141 aacagcggct gttctgtgcc ttcaaagccg atagcgataa agacaagctg agcaggccat 1846201 actttttccg ttccaggcag ctcgcggaac tcgtattttc catgctcatt tttcactttt 1846261 tccatttgga tggtatgaag ctctttcagc tttccgtttt tatccgcgac catttttgtc 1846321 gtttgaatgg agtattctct cggatctctt ccgaattttg cttctgcttc ctcgtatgca 1846381 tattcaagcg taaagacgtg tggctgttca ggccacatat tgtcattcgt gcgggctggc 1846441 ggaagtttcg ggtgtttgcc gaattggtgc acgcttttgg ctttttgacg cagagcggta 1846501 gccacacagt cagctcctgt atctccgcct ccgattacga tgacatcttt ccctttggca 1846561 tcaatgaatt gcttgtcttt aaaattagaa tctaaatagc tttttgttgc aagtgtgagg 1846621 tagtccattg cgtaatggac tccttttgag tcgcgtcctt cgattaagag gtcccgctgt 1846681 ttttgagcgc ctgtgcataa gatcacagca tcaaattgct cctttagctc atcagctgta 1846741 atgtcaacac cgatttctgt gttcgtgaca aaatcaattc cctcttgcgt cagcaattta 1846801 attcggcgtt ctacaatgcc cttctcaagc ttcatgtttg gaatgccgta tgttaaaagg 1846861 ccgcccgctc tgtctgctcg ttcaaaaaca gtgacggaat gtcccgcttg attcagctgg 1846921 tcagcactcg ccagtccggc tgggcctgac ccgacgatgg ccactttttt gcctgttcgt 1846981 ttttttggaa ttctaggttg aatccagccg ttctcaaatc ctttatcgat aatggtccgc 1847041 tcgatgtttt taattgatac ggccggatct gaaatcgcta aagtgcatga tccttcacaa 1847101 ggagcggggc atacccgccc tgtgaattca ggaaagttgt ttgttttcaa cagacgttcc 1847161 aatgcttcct tccatctgcc ccggtagaca agatcattcc attcaggaat taagttgtaa 1847221 atcggacagc cggatgtaaa tccgttaatg tccgcaccga tctggcaaaa cggtgtaccg 1847281 caatccatac accgcgcccc ttgccgtttc gatgcttctt ctgaaaaagg agcagaatat 1847341 tctttccaat cctttaagcg agtgagaggg tcccgctccg caggtttttc tcgtttgatc 1847401 tccataaatc cagttggttt ccccatgttc ctctcccctt ccttactgta ctaccgcttg 1847461 tttttgtccc gatgctgctg tattctgctt tggcttcgtg ttggcctcaa aagcgaacat 1847521 gatggcttct tcatctgata aacctgcagc tttttgctct tcgatgcttg cgagcatttg 1847581 tttatagttt ttcggaatga ctttgacgaa ttttttcaca ctgtcttccc attgatctag 1847641 cagatcttct gctttttggc tgtttgtata cgcagtatgt ctttcaagca ttgctttgat 1847701 ttgctggatt tctttctcat cctctaatga ttcaaataaa atcatctcaa ggttgcattt 1847761 gcgtttaaac gctttgacat cttcggtcag tacataagcg attccgccgg acatacctgc 1847821 cgcaaagttt ttgcctacat caccgagaac gacaacgctg ccgccagtca tgtattcaca 1847881 gccgtggtcg ccgatgcctt ctacaactac gttcacaccg ctgtttcgaa cggcaaagcg 1847941 ttcaccagca cgcccgttaa tatatgcttc tccgcttgtc gcaccgtaaa aagccacgtt 1848001 gccgataatg acattgtcat ccgaagcaga gttgaatcct tctgatgact tgacgatgat 1848061 ttttccgcca gaaagccctt ttccgacgta atcatttgag tctccgtcca aataaagcgt 1848121 catcccttta ggaacgaaag ctccaaagct ttggccggct gatccggtaa agtgcagctt 1848181 gattgtatct tcaggaagac cttcttctcc gtaacgcttt gagatttcac tgccggttat 1848241 cgttccggct acacgatttg tattattgat ttcaatcgaa atatcagctt cttttccaga 1848301 ttcgatggct tcttgtacgg ccgggagaat tgttgtaata tcaagtgatt gatcaatttt 1848361 atgattttgc ggcgattgga acgtccgcac cccttcaggc tgataaagaa gggtagacaa 1848421 atcaagctgg cttgctttcc agtgctcctt tgcccgttca cttgcatgaa gtacatcagt 1848481 gcggccgatc atttcatcaa atgtcttgaa gcctaacgca gccatgtact cacgaacttc 1848541 ttcggcaatg aacagcatat agttcacaat atggtcagga tctcccatga actttttgcg 1848601 aagctctgga ttttgtgtcg ctacaccgac agggcatgta tccaaatggc aggcacgcat 1848661 catgacacag ccgagtacaa ctaacggagc cgttgcgaaa ccaaattctt cggcgccgag 1848721 caaggcagcc atcacaacgt cgcggcccgt catgagcttt ccatctgttt ctaatacaac 1848781 acggtcacga agtccgttca gcattagtgt ttgatgtgct tctgcaaggc caagctccca 1848841 cggaagccct gtatgtttaa tactggtttt cggagaagcg cctgtacctc cgtcatagcc 1848901 gctgatcaca atgacatctg cagtcgcttt ggcaacacct gcagcgattg ttcctacacc 1848961 tgcttttgac accagcttta cgctgattct tgcgtcacgg ttggcatttt tcaaatcgtg 1849021 gatcagctgg gctaaatcct caatcgaata aatgtcatgg tgtggcggag gtgagattaa 1849081 tccgacacct ggcgttgacc cacggacatc ggcaacccat ggatatacct tgttgccagg 1849141 aagctgcccg ccttcacccg gcttagcacc ttgagccatt ttaatctgca gctcatcagc 1849201 attgacgagg taatggcttt tgacaccaaa ccgtccggat gcaatttgtt tgatcgcact 1849261 tcttctatca tcgccgttct catctggaac aaagcgtttg ggatcttctc cgccttcacc 1849321 gctgttgctt tttcctccaa gacggttcat tgcgattgct aaagcttcgt gcgcttcctt 1849381 actcaaggac ccgaatgaca tcgcacccgt tttaaaacgt ttgacaatcg attcagcgga 1849441 ttcaacctcc tccaacttca aaggcttgcg gtttccgtca aatgcgaaca agttccgcaa 1849501 aaatccgatg cgttcttcat cagccgcttt tgtatactgt ttaaacagat tgtaatcatt 1849561 tctgcggcac gcccattgca aagtatgaat cgttttcgga ttaaacgcat gatgctctcc 1849621 gccatttctc cattggaagt cacttcccgg ttcaagcgtt ttgctgtaat catcctgata 1849681 cgcttcccgg tggcggcgct gtgcctcttc tgcaattgtt tgtaaatcga tgccgcctag 1849741 ctgtgatgca gtacctgaga aatagcggtc gatcacatcg cggctgattc ctaccgcctc 1849801 aaagatttgt gcgcctctgt agctttgcac agttgaaatt cccatcttgg acatcacttt 1849861 tacgacgccc tcagtaatgc tttttccata tttgctaacc gcttcttcat agctgatatc 1849921 caaacggcct tcatcaattt cctgcttgta ggtcgcataa gcgagataag ggttaatcgc 1849981 atctgcgcca taaccgatta acgctgcaaa gtgatgcact tcacgtgctt ctcccgattc 1850041 cacaataatg ctgaccttcg tacgcagccc tttgcggatt aagtgctggt gcagtgcgct 1850101 tactgccaga agcggcggaa ttggtgtcag tcgttcgttc atctttttgt ctgataaaat 1850161 taacaaactt acgccttggc tgatggcttt ctctgcctgt gtgaacatgt cctttaaacc 1850221 gcgttcaaga tcctctgaaa acagcacatc aattttttgg ctttttaaat caggatgaac 1850281 aatcgttttc aatgcgtaaa actgttcatt ggataaaaca ggtgtataca gtttaatccg 1850341 gcgaacattt cgttcacttg gatgaagaag atcgccttcc gcaccgagcc aagtcatcgt 1850401 tgaagtgaca agctgctcac gaatcgcgtc gattggcggg ttcgttactt gtgcaaacag 1850461 ctgtttaaag tagttaaaca gcgattgcgc tcggtcagaa agtacagcaa gcggagcgtc 1850521 attccccatt gaaccaaggg gatctttgcc ttctttaata acaggaatta gatacttttg 1850581 gatatcctca tatgtgtatc cgaatgcctt ctggcgagta agaagatcac taaattgttc 1850641 ttcttctctt gactccggat caggatttac ttgtacaagc tcttcttcaa gccatttttg 1850701 gtacggatac tcagttgcaa tttgtgtttt gacttcctca tcggagataa tacggccttc 1850761 ttccaggtcg attaaaagca ttttcccagg ctcaaggcgg tttttatata aaacgttctc 1850821 ctgttcaact tcaataacgc ctacttcaga tgagaaaata atataatcat cttttgtgac 1850881 ataataacgg gccggacgga gaccgttccg gtcaaggatc gccccgattt gtttaccgtc 1850941 agtaaatgaa atagctgtcg gtccgtccca aggctccatc agggagctat ggtactcgta 1851001 gaacgccctt ttttccttgg acatatgcgt attttccgtc caaggctctg gaatgagcat 1851061 cattgccgta tgtgccggtt tgcgtccagc catcacaaaa aactcaaatg cgttatccaa 1851121 aatggaagag tcactgccat cagcattgag aatcggcaaa atcttgttta agtcctcacc 1851181 gaagctttca gaaacaaatt gctgctcacg tgctctcatc cagttgatat ttccgcgaag 1851241 ggtgttaatt tcaccgttgt gaaccaaata gcggttagga tgcgctcttt cccatgtagg 1851301 gaatgtattg gtactgaagc gtgaatgaac aagcgcaaaa gcagaaacga atgcttcgtc 1851361 ttgcagatca gaataaaatg catcaacctg ttcaggtgtt aaaaggcctt tgtaaacaat 1851421 ggtctggctt gaaagactgg caaaataaaa atcaagacct tccgttactc cccaattttc 1851481 agcctgttta cgaatgacat acaattttcg ttcaaaagat aaattgtcct ttagatcaga 1851541 acttgcgccg ataaatacct gacggacaaa cggacagctt ttttgcgcca ctgttccgat 1851601 ttttccgaca tttacaggta cagttctcca tccaagaacg acttggcctt cttgttcaat 1851661 tagtgcattg atttgctttt caattttttt tctttcatct tccttctgtg agaaaaagac 1851721 cattcctacc ccgtaacgtt ctttttctgg cagattgatg tttttgcact cttttctaaa 1851781 gaaagcatca gggatttgaa ccagtaagcc ggctccgtct cctgtatccg gatcactgcc 1851841 ttgccctcct ctatggtcta gctggcaaag catcttaagt ccttgtttga caatgtcgtg 1851901 agtctgcttg ccctttaagt gtgcatatag gccgattccg catgcatcat gttcaaattc 1851961 aggacggtag agaccttgag cttttggcat ttgattgtac gtcataattc ctctcccccg 1852021 atcaatttcc gataataccg gtcataaaat ctaacaactc tataatcatt gtaggttttc 1852081 aaaacgatat aaacaatata taatttagat caaaagaatc tcaaaatgag atagatggat 1852141 gtgagacaaa catggagctg cgccaactgc gttattttat ggaggtggct gaaagagaac 1852201 acgtttcaga agccgctgat catttgcatg tggcccaatc agcaatcagc agacaaattg 1852261 ccaatcttga agaagaatta aatgtgacct tatttgagcg tgaagggaga aatatcaaac 1852321 tcacgccaat cggaaaagaa tttttaattc atgtgaaaac ggcgatgaaa gccattgatt 1852381 atgcgaaaga gcaaattgat gagtatcttg acccgcatcg cggaacggta aagatcggct 1852441 ttcctacaag cctcgccagc cagcttttgc cgactgtcat ttcagcgttt aaagaagaat 1852501 atccgcacgt cgaatttttg ctgcgccaag gctcctataa gtttctgatt gaagctgtca 1852561 gaaaccgcga tattgatctg gccttattag ggccggtgcc gacgaatttc tctgacataa 1852621 cgggaaaaat attatttact gaaaaaattt acgcgcttgt tccattaaat catccgcttg 1852681 ctaaacaaaa aacggttcat ttaatcgatt tgcgcaacga ccaatttgta ttgttcccgg 1852741 aaggatttgt acttagagag atggcaatcg atacttgcaa acaagcaggc tttgctcctc 1852801 tcgtttccac ggagggtgag gatttggatg cgatcaaagg gttagtgtcc gcaggaatgg 1852861 gcgttaccct tctgcctgaa agtacttttg ctgaaacaac acctcgtttt actgtgaaaa 1852921 ttccaattga gttccctcaa gtaaaacgga ctgtcggaat cattaaaccg aaaaatagag 1852981 agcttgcgcc ttccgcgaat gatttttatg agtttgtcat tcaatttttc tctaagctgg 1853041 agcagtatca ataaaaaaaa tgaacccgag cttctatata gaagcttcgg gtttttttct 1853101 gcaaattaat ttacaggtaa agaaaaatcc acatggcaaa caaatgcttc ttgatcaatt 1853161 agagctctat ttgtcagttc ctttttcttt tccggttctt gaagctgtac agaagagtaa 1853221 ttgacgattc caaggccgat ttccgtccct tttgaatcca tcagccgaac aactgaaccg 1853281 cttttgaatt tccctttaat cttctgtaca ccgtctaggt ataaactcga ttgtccgttt 1853341 gttatttttc gtgaacaatc atctgataaa atcatttcac cttccggacc ggaattaaaa 1853401 gcgatccatt gctccttttg attcaacgga agcgttcctt ctgcttcaaa ataggtgcct 1853461 tccgcctgtt catgaacggc gtggtataaa atatcgccag catctgcctg acctaggaaa 1853521 cctttaatgc cagacgccat tacgatttta aacgcatcaa gcttagagcg catgccgccg 1853581 gtgccaacga tgcttccagt gtcacctgcg catgcttcga tgtcaggtgt tatttcactc 1853641 acccgctgta tctttttcgc ttctggattt gtgcgcggat tgccgtcata taatccgtct 1853701 atatctgata aaatcacaag catatctgca tcaatcaatc ctgcgacttt tgctgcgagc 1853761 gtatcattgt cgccaaactt gagccgattg acggtaactg tgtcattttc gtttatgatc 1853821 gggatgatgc cgcgctcgag cagtacattc attgtattcc tgacattgtt gtatcgatat 1853881 tcatcagaaa aatcgcttct cgtaattaaa atttgggatg cgacatagcc gtgtgccaaa 1853941 aacagctttg aataagcctc cattagcaat ccctggccga ttgaagctga tgcttgtttt 1854001 tctggaagct tctcgggcct ttggataaat ccgagcttcc gatatcccgc cgccactgcg 1854061 cctgaggaaa ccaaaatcac ttcataaccg gcgtctttga gtttgacgac ctggtcgacc 1854121 aacgcttcta attttcgaat gctgatttct ccatgaaggc ttgttaatga actgcttcca 1854181 atcttcacaa cgactctttt catgcttgta tcaggcgtca ctttatcact cctgatagcg 1854241 gcgctgcagt tttttcgata tcttcgctga tttcctttga acgcttagcc gcatgcttta 1854301 ttgcttgaga aatcgcttct ccgccgccgc tctttttcaa ggcttgcagc cccgctgctg 1854361 tcgttccgtt cggtgacgtg atattatctc ttaagatctc aggatgttct cctgtttcca 1854421 tgagcatttt tgcggcacct aaaagtgtct gtgcgccgat gcttcgagat aactgtttat 1854481 cgaggcccgc ttcctcgcct gtcttttcaa tgaattccat taaataataa aaatacgcgg 1854541 gtccgctgcc tgcaattccg gtgaatatat ccatttgatt ttcttggatt gtatagactt 1854601 cgcccatgca tccgagcaat gcttcggcca gcttcttcag gtcttccgac acatatttgc 1854661 caagggcaat agctgttgca gaagcgccaa tcatactgga agtgttgggc atcactctga 1854721 caaccggctg ttcattaagc aatgattgtt caataaaaga ggtagttatg ccggcaagga 1854781 ccgacaatat taattgatgg ggttgaatac gtgattttag tgatgacaga gcgttttcgg 1854841 cgtcttttgg cttcattgcc aaaatgagca catccatgtc ttcaatacat agttggttcg 1854901 gcaaggcgcc tttaatgcca tattgaagtt caagttcagt taatcgctct gtattgctgc 1854961 ggtttgtaac gcagatgttt tgtttcggga ttttgttggc tcgaacgata cctgatatca 1855021 ttccttccgc catagatcct gctcctataa aggctacttt cttttgatca aagatcggta 1855081 acatctcctt tgttcgcttt tttgttcgca ttttcacacg tttaaaatgt taccacgtga 1855141 ggaaatgatg tcaagtttga aggccattat tgatttgtat tgtttctttt cgacaaatat 1855201 gtataatgaa aagcagaaaa cacccggttc acactgctgc gccgggtgtt tgtttctatt 1855261 aaaaattatc tgagagagct ttttcaatca gttttttaca gcgatccagc tctaccttca 1855321 gctgtttttt atatagcttg gcagcttcgt aatctttaaa ttgatagagg acgacttcct 1855381 ggagcttagc cccttctttt tttactttaa tttgttttag tatcccgtca tcaagaagct 1855441 catgcaaaga ccggtatact tctgtatgat ttggtttaaa accaatctct ttaaattcag 1855501 accgaagtac ttcaagcagc tttaacccat agagtctctc ttgctctgtc atcgttatca 1855561 tataaagctt caaaaatgcg cgctgtttca ctaaaaagcc tgttgaactc cttttttctt 1855621 ctttcatcat atgcactcct tcttctgtca ctgacaacac tatgtactaa atattcaatt 1855681 ttcttttatt gttttccttc tttatattaa agactgatag tccagttatt tcatgtttac 1855741 tgattatagg tgtagcggaa aaaataaatt tcgactgaac atttggtaca tagttttctt 1855801 agttctatta tagcctgcat ttactgctat cttcaattta aacgattgcc agggtttaca 1855861 tatctcattt taccggtacg gatttcattc aaataaaaaa acctgtcgaa agacaggttt 1855921 tcatttttaa ggatttgttg accataatcc cgctgttttg atgaaaatac gaggatctaa 1855981 tttcagttgt gccaccatgt actcagcaag atcctcaggc tgcataactt tttcaggatt 1856041 accgtctgtt aagttcaatt cgatagacat atcactagcg acagtgctcg gcgttaacgc 1856101 gctgactctg atattatgtt ttctcacttc ttgcataaga gactctgtta acccgagaac 1856161 ggcaaattta gaagcgctgt aagcacttgt tacagcagct cctctttggc ccgctgtaga 1856221 tgaaatatta atgatgtctc cggctttgcg ttcgatcatt tccggaagca ccgcgcgagt 1856281 gacatggtac acacccatta ggttgacttg aataatattt tcccactcat cagctgacag 1856341 atctaagaaa ccgccaaatt tgctgatgcc ggcattatta atgaggatat cgatatcacc 1856401 gagctgttcc ttcacttgag ctacagcttg gttaacctga tcggcatctt ttacatctgc 1856461 agcagcaaat gcagctttta caccaagcgc tttgacttct tcagccactt tttctacatt 1856521 agcggaagtc cggccaatta acccgatatt cacgccttct ttggcaagcg ccagagcagt 1856581 agcgcggcca attcctctgc ctccgcctgt gattagtgca gttttatgtt gtaaactttg 1856641 caattgaagc accctttctt tgtttacata tgtacgatat cacattataa gtacaataca 1856701 tccaatacgc aaatcaaacg aactgtgtaa atatcatttc ttctgattaa aaaaacggat 1856761 acagggtaat gacataagaa aaggagtgaa catatgatta tagtttatat cagtcttgca 1856821 gtattagcag tttctattat cttcttagga gttaccgtga tccaaaacaa gaaaaaaata 1856881 gaccccgcac taaaggagct ttcctctgtt acgcaggcta tgcaaaaaca aatcgaagga 1856941 ttaaaaacag aaacagagct gctgacgcaa aaacaaaaga agattcagca ggatgtccaa 1857001 ataaaaaaat acacgcttca gcagaccgca gctgaagtga aagaagttcc ccaagcagtc 1857061 aaagaggtgt ggcaggcagg acattttaat agcagataag gatgaatgag atcccgttgt 1857121 tacgatcaga atggacaaat gggatctcat ttttcgagga ggcttacaca tgattataaa 1857181 ccgcagctgc ttaaaagagt tcgcagaaaa agtacatttt cttccctctt cacttacaaa 1857241 gtccgattta cttactgatc catttcgtct ccatcaagaa aacgaacttg gcatctacta 1857301 ttcacctcat aatgaattta tcaatcggga tgcctcgctt gtgattgccg ggatcacgcc 1857361 tggtttttcc cagatgaaga cagcgtacga aacagccgcc gaaagcctgc tgcaaggcgg 1857421 gactcttgag caaatggcag tagacacaaa aatagcagcg ggtttctccg gatcgatgag 1857481 acataacctt attaccatgc tggatttatg cgggctgccg caagcttttg gcattcaaag 1857541 cgccgcaaag ctttttggag aattacggca tatgctccat acaacttccg ttattaaata 1857601 tcctgtcttt atccagcaaa aaaactatac cggatacaaa ccggctatca ctcattctcc 1857661 tatcctaagc acttatgctt ttgggcactt ccctgcagag cttaaccatg tgacgggacc 1857721 agctcttctc attccgttag gaaaagcggc cgaaacagtg tgtgaaacat tgatcagaca 1857781 gcacagcctc cagaatttga tttgccttaa cggctttccc catccatcag gcgcgaacgg 1857841 ccatcgtttg aaacaattca gcaaaaacaa agagcaacta gaaagacaaa ttcgttcctt 1857901 tgctgcattg gttgatttcg ctatagaaaa gaggaaataa aagggatatg ataaacaaaa 1857961 acacaaacgt ggggagtggt tgaatgtttc ctatattaga aacggatcgg cttatactta 1858021 ggcaaatcac agatcaggat gcggaagcca tttttgcttg tttctcaaac gatgaggtga 1858081 cacgctatta tgggcttgaa aacatggaat ctatagaaca ggccatttca atgattcaaa 1858141 cgtttgctgc cctctatcaa gaaaaacgcg gtatacggtg gggaattgaa agacgggaca 1858201 ctaaagaact gatcggaaca attggctttc acgctctggc ccaaaagcat aggcgcgcgg 1858261 aaatcggtta tgaaatcatc ccggagcatt ggcgaaacgg atttgcatca gaagtcattt 1858321 caaaggtcgt atcttacgga ttttctgccc ttggactgtc gcgtattggc gcagttgtat 1858381 ttaccgataa tgaagcatca aatcgtctgc ttctaaaaat ggggtttcaa aaagaaggcg 1858441 ttttaagaca gtacatgtat caaaatggga ctccatatga tacaaatgtg tactctattg 1858501 tgaaaccaag agaatgacgg tattctcttg gtctgtgcca catccctttt cctttaaaaa 1858561 gataaaaagc gcccctcaaa cagggcgctt tctaattaag atgcatattg aggagatgtt 1858621 tcctccttaa ctgctttttc ctcaggtata tgaatacatt ttgtcaagac cgcacttgca 1858681 aggtaaaggg ccgcaaagat ccagacgaca ccttgcgcgc cgacgagacc gatgaacagc 1858741 caagcgagtg cagggccgac aaacgctgat aaacctgcag ctaaattcaa tacagacatg 1858801 gctgcccctt tatcttttcc tgccaccgtc ggcacaattg caccaatcgg cacatagcct 1858861 gccagcaaac cgccccaaat aaagccgatc acgctgacaa ccgctaaact tccgccggag 1858921 aaaacaggtg cgtagtataa taagacggtg aaaatgccgc agccgactcc gccgaaccaa 1858981 ataacagtat ttttccagcc gaatttatcg ccgacaatac cgaagataag gttaaacaca 1859041 atgttcccca ggaaaatcgt tccccaaatt tgcagccaca cattggttga aattccatgc 1859101 tgggccatgt gcatcggcaa aaagactgga aaaccatatg taccaatgct gttgatgatt 1859161 ctgatgattc cgcctgtaag cacgcgcgga tttgtaaata gaatcgtaac cccttttaaa 1859221 agctcctcgg ctgtttctga tctttttctt ttcttctttt caaaacggtc tttattgata 1859281 aacaatgcaa agaatgcacc gagacatacc cagaaaatag agctccaaag cgtattcaaa 1859341 taaccgaacg ctttgatcgc gtagcttgag taccaagcgc cgaacacaaa catgccgagg 1859401 caatatgcaa tccaaaacca gccgacagca gtgctcagtt tgctttgcgg tgttctgtaa 1859461 atgacccatg tcaagaaaga ataagcaaaa agcgggtaac ctaacccttt tacgaagtaa 1859521 gtcacataca tcactggcag gttcagctgt tcaaatccaa atacgataaa agcagctgta 1859581 ccgatcacat aaaacaacag ccccataaac atcgttcgtt ttgcgccaaa tgcttcgaga 1859641 catacacccg aaaaccagga agctatggca agcgcaattc cgtatatact aaaaatggaa 1859701 gcggactgct gaacggtgag cccgttttcg atcaaaaaag gactgagcca gccttgttca 1859761 aggccatctc ccatcataaa caaaacaacc cctaaaaatc cccaggcaag ccgcttcggt 1859821 attcctattt tatccaacat atctgtctcc tccttagatg ctattattca ttaccgtatt 1859881 accttattaa agttgaaaat taaatgattc ctcaaaacag cagaaattcc gtcttaaatt 1859941 aatactttgc tttctgatcc tgaaaaaaag cgctgtgttt gcttccattc ctcatataaa 1860001 gccaattcta tctgacagtc cttcggttcg atcacccgga catttgctga catctcctcc 1860061 gttaattgaa aggtttcatt gcaaatgact gcagcaccga cgacagatgc ctgatgatat 1860121 ccctcttgga catagacctt tttttgaaga agatccgcga tatattgagt gagcgctttg 1860181 ctttggaatc cccctccgca cacccaaaca taatcacgtt caaacggagt aacctctgtt 1860241 aaaatgtcaa agttccattt gattgaaaat gcgatctctt ctagcgctgc acgtacaaaa 1860301 tgtgccctct ttaaatgtgc tgacagcggg gcatcaaaaa gaaaaccgcc tctcgttaac 1860361 gcattctttt cagccgataa ataagagccg agagccgcta cacatgcatg gtcttctttt 1860421 gcaagtgcag aaatctcctc ctccattact tcgtacgttt cattcggata aaaaatctgt 1860481 tttaattttt gataattcaa gccggtaatt cccggattcg tttccacaag ccaatgccct 1860541 tgatccgtat gacagttcaa ccaggcttta tgttttgtgt cgccatgatc ctcagtaatt 1860601 ttggttattg gcgttgttgt ccctgataca atgacaatgt cctcaagtcc agctccggtg 1860661 cttttgacag ccagctgtgt atccccgccc cctgctataa ccttagcatt tattgaaagg 1860721 cctaattcgg atgcatattc atttgctatc gttccaattg ctgttcccgc tcttacaaga 1860781 ggcggaagga tagatggaga aaagccgaaa atgtcgcaca tctcttctga ccaagtgttt 1860841 tgcttcacat caaatagcag ggtttctgtt gcctgtgatg gttcatatgt taatattccg 1860901 ctcagttggt acgtcaccca atcactgatg cttgtaaagc ttgcagtctt ttcccataaa 1860961 gagggctggc gctgttttaa tccataaagc ttgagcgcag aaaaaagtgc agttggcagg 1861021 cggcctgtgc tgctgtatat ctcttcccaa tcgggaatgc ccgcctccca ctctcggccg 1861081 cgattatcga tgttcggcag cccgagaaaa ggattgccgt tttgatcaat caaaacaatc 1861141 ccctgtcttt ggctcgtcga tgtcaaacca atgatgtcaa tatcacacga acgggatagc 1861201 gcacgttttg ccaaattcat cacctgcttc cacagcacct gaggagaaaa ataacggctg 1861261 tccgggtaaa gcgtctctgt ggaatactcg atgtcctccc gttcaactgt tagaacactg 1861321 ccagttacac tcacgaccgc taccctcgca ttgcctgtgc caatatcaaa aacgagatag 1861381 cctttttgtt ttttcattct gttagcctcc tttcttatcc ccctgttttc agtgcgtcct 1861441 tgttatacat tgtctgaata ttaagagttt tttcaccctt ccactttttg agggctttat 1861501 tcagtatcgt cacgtgatga tcctccactt caaatgttgc tccagcgaga tgcggtgttg 1861561 ccagaacatt aggcaatgaa atcaattcat aatctgattc ctctggaggt tcatgataaa 1861621 aaacgtctag tatcgcaccg ctgattttat gttcttttaa tacaaataaa agatcttcac 1861681 ggtttacaac aactgctctt gaagtattaa cgaaaatcgc actctctttc atcagatcaa 1861741 aatattgccg atctatcagt ccgagtgttt cctcagtgcg aggcagatgg acagaaacga 1861801 tatcgctgtc tgaaaacacc gttttaagag atgctttttc atacaacgga tgatcgtctt 1861861 gaatgtatgg atcgtaatat tttatcttac agtcaaacgc agtcagcagt tttgcaatcc 1861921 tttgcccgac tgcgccgaac ccaatcatgc caaccgtttt tcctgttagc tcatttcctt 1861981 taaatttgac ataagcctgc aggtaatcac tgtcccactc tccatccttc agccactgat 1862041 tcgaggcgct ggtatggcgc agaaaggaaa tcacatttcc aataaacatt tcggcaacgg 1862101 cttgtgcatt ccgccctggt gtataaaaaa caggtatgcc cctttttgag gcagctgcca 1862161 catccacatt tgagggcatt cccctgcaaa caccgacaaa tgaaagttcg ggaacagaag 1862221 caaatacgct gtctgttacc tgatcaagtt cagtaatcaa gcctgtcgca tttgttgctt 1862281 ttagcagctg aatgagttca tcctcccgat atgccctacc ttgttccttc caagattgat 1862341 aagcaactga gccaaacaag ttttcaagct cttttcgtcc ttcttcgttg tacggtgctg 1862401 taaccaaaac cgtcatgctg caaaacatcc ttttcatcgt atttttcata aaaaaaatct 1862461 ctttccgaag atggaaagag attcatatat aggcgcgctc tgttacaggc agacgccggt 1862521 ataaaccttg ctttcctatc tttcaagcta gcgcttgctg gaattggcac aataatgttg 1862581 ccgaggtttc atagggccag tccctccacc tctctggata gaaaatattg agtatgtaat 1862641 tttcagaatg aagaatacgt ttatcataaa gaagactcag attgatgtca atctcttttt 1862701 ttcagaattg acgttatcat cggaaatgtt ataattctta caaaatatct aactagagag 1862761 aggaactggg ccatgagatc ttttgccaca caacaaaacg gcattttcaa atccgtttgc 1862821 tcgctggact gcccggatca gtgcggattg ttaatacata aaaaagacgg gaaaatcgta 1862881 aaagtgcaag gagaccctga tcatcctgtc acagctggaa acatatgcaa caaagtccgg 1862941 aatatgacgg agcgcatcta tgatgaaaag cggctgacta caccgctcaa acgaacaggt 1863001 gcgaaaggcc aagcgatatt tgaaccgatt tcctggaaag aggcaatcga tacgatcacc 1863061 tcccgctgga aacagctgat tgatgaagag ggagctgaaa gcatacttcc ttacagcttt 1863121 tacggaaata tggggaaatt gacagctgaa ggaatggacc gccgcttttt ttaccgcatg 1863181 gggtcaagcc agcttgaacg gacgatttgc agcaaagcgg gatctgaagg ctataaatat 1863241 acaatgggca taagcgcggg aatcgatcct gaggaaaccg ttcatacaaa actatttatt 1863301 ttttggggaa tcaacgcggt cagcacaaat atgcaccaaa ttacgatcgc ccaaaaagcg 1863361 cgaaaaaaag gtgccaaaat tgtcgtgatc gatgtgcata aaaatcaaac aggacgtctt 1863421 gcagattggt ttatcccaat aaaaccggga accgacagtg cacttgctct tggcatcatg 1863481 cacattttat ttaaagaaaa ccttcatgat gaagcatttc tgtccgagta cacggttggc 1863541 tatgaagagc tccgtgaaca cgtgaaacaa tatgatcctg aaaaggtatc gacgatcacc 1863601 ggtgtcagta ccgaagatat ttaccgactg gcaaaaatgt acggggaaac ctccccttct 1863661 tttatcagaa tcggaaacgg accccagcat cacgataacg gggggatgat tgtaaggacg 1863721 attgcctgtc ttccggcgat caccggccaa tggctgcaca cagggggcgg cgcaattaag 1863781 cataacagcg gaattttaga atataacaca aatgccttgc agcggcccga cttattgaaa 1863841 gggcgcaccc cgaggtcgtt taatatgaat cagcttggca gggtgctttt ggaaacagac 1863901 ccgccgattc gctctctatt tatttacgga acgaaccctg ccgtcgtcgc gcccgaagca 1863961 aacaaagtca gacagggctt gctgcgggaa gacttgttta ctgtggttca tgatttgttt 1864021 ttaacggaaa cggctgcata tgcggacatt gtactgcctg caacatccgc ttttgaaaat 1864081 actgattttt acacctccta ctggcaccat tacattcagc ttcagcagcc ggtgattgag 1864141 agatatgggg aaagcaagtc taacactgag gttttccgat tactggctga agccatggga 1864201 ttcacagacc aggagcttaa agattcagat gaagtattaa tccgccaggc gcttgaccat 1864261 ccagataatc cgcatttggc agagattgat tacgattcac ttactaagca ttcatttatg 1864321 aaagcgaaac gtgaaaagcc gctgtttccg ggcgaacttc caacgccaag cggaaaaata 1864381 gaattatatt cagaaaaaat gaaacaagac ggcttccctg ctttaccgac atatacacct 1864441 cttgtaaccg ataatgaaca tccgtttatg tatgttccgg ggccaaacca taatttctta 1864501 aactcaacat tttccaataa tgaaaaacac atcaagcttg aaaagacgcc aaagctcttt 1864561 atcaacacaa aagatgctga aaaacacgga atcgttgatg gggcacctgt acgaatttgg 1864621 aacagccggg gagaatgcga gctgaccgct gcagttggag aacaagtgct gccaggtgtc 1864681 gttgtcagcc aaggattatg ggcggatgaa caaggaaaaa aacagcttgt aaacgcgcta 1864741 accccagatc gcttgtccga tatgggcggc ggcgccacct ttttttcagg ccgtgtacag 1864801 attgaaaagg tttgaaaaat aatgaaaccc ggagtatgcc aagcccgtat aacataacat 1864861 cgacataatg gaggcataca catggacgtt tttttaggaa ttggtattgc tttggctgga 1864921 tattttatcg gtgaaggctt aaagcagagg aaccaaacca aaggtaatga acaaaatgat 1864981 atcttcctaa taaaagaacg ggatatttac ttttacattg gacttttttt aggaataaca 1865041 acgactgaag caaaacagtt agctggagac atggcagacc tgccttacat cgaaataaac 1865101 ggaaaaaaat atgtccagaa acatatgtta aaagattgga cattcacatt agttgaaaaa 1865161 catcagggtg aataaaacaa atctgaggag agcgagattc attgtcacgc tctcctctgt 1865221 ttagctgtat ggatcctgcc accaaaactt tgtgctataa gcgctgataa aacgataaac 1865281 caccatctat gttctttcct caaacaactc aagatgcccg ttccacaaca atagttttta 1865341 tattcctttg atgacgtgat gttcttgatg aacgtatgta tcgtaaaaca cttagaaaac 1865401 ctattcggtt tgaatgtgtg ctctcattat gcccccatac tgcgccttta tccgcggagg 1865461 atttttttaa aaaaatatga aacctaaagc ttttagatcc tgaattttta ttgaacctcc 1865521 atatttctcc gattggtaaa aattagccta tacaccggaa gctgtacgtt tataaaggat 1865581 cagagaatcc cataaccagt aaatcactgc agccgcaata cttaacatat aataaaagta 1865641 cgattgcaat gtccatgcta ttgacgcagg ttcattgata acaaaaaaca ggaaagctgc 1865701 gataaaagca accacactgt aaatcaatag gtacatgaca ttgaaagttc tcgctttttt 1865761 ctgcaacttc atttggagcg gaacagcaaa aaggccatac accacaaaac cgtataataa 1865821 agcaattgct gccgtaaaca atgcaattat catatcgcca tacataacga aagaataaaa 1865881 ccctaataac aaaccaaatg taaggctgga tagccctaat gtcattaaat aatatgatgc 1865941 gatttttttc attttttcac cccccttgtt tgatttattc acagtgctgt tagtataaat 1866001 tcacaacctt tgtatttctt ttatcgagat gtcttcccta acgtgctata cgcaatgcgc 1866061 taataaaagg tttcaaaaat gacgttcttt tattagataa tacgctggct gaaaacgcct 1866121 ctcctgattg gccaaagcgc gaatgaaaaa agtgcatgaa tacctgccca acagacagaa 1866181 taagaagagt tgatatttca acacttttcg taaaggggtg aaaccaatga gtaagaaagg 1866241 tattcaaaat tcaagtattg aacaaataag aaatgaccat gagactgaaa cagcttttaa 1866301 agcagatgat cctaaaaaac acggttccga tcctaaaaga acgaaataag ttcttacccc 1866361 cactaaaata tcaataatct ggaggaagta aagtgactca aaaaaacggt gcagacagac 1866421 ctgatgatta taaaagattt tcttcattag acaaggaata tgattttcag caatctatac 1866481 gcagcaatac tgagacagaa agtgtaaaca ctgaaacaca aactcataac aaagaaaaca 1866541 aaaatgacac aacagatgtt gccgggaaat actttgagcc ctcagattat aaaggaagca 1866601 cgcaattaga aaaaggattg gctgaaactc atgaacaggt cagcgatgac tattttgaag 1866661 ggacaatcga tcaaaatttg gactagccat acaaacggaa ctaacttaaa agaagtcagt 1866721 taactctgtt tttagaaaca accacagtaa aagtagccaa cccccaccga ataagatggg 1866781 ggttgcacgt aagtagcctg tttaatattt aaaacgatta atgacggttt gaagttcttc 1866841 tgccaactga gatagagatt ctgcggcata ggagatttcc cccattgaat gaagctgttc 1866901 ctgtgatgaa tttgcaaccg cttctgtatt tgctgacgtt tcttttgtac cagcagccaa 1866961 tgtatgaact gtgtgctgaa tcacttcaac gcctgaagta agctgttgag ttgctgctgc 1867021 aacttcttgt atttgagaag tgacctgttc caccaggttc agtatttcat tgaaatttcc 1867081 tgttgtctct tgagaaagaa caatacctga gctcacattt tcttgaacaa ctttaatatt 1867141 atttaccgtt tctatcgatt cgttttggat ggtcgctacc accgattgga tgtggtttgc 1867201 agatttattt gtttcatccg ccaacttccg aacttcttct gccaccacag caaatccttt 1867261 tccttgctct ccggctctgg ccgcctcgat cgctgcattt agtgccaaca aatttgtctg 1867321 ctctgaaatc gtcgtgataa gcgaagagat atcgctgatt tctgctgtgc tcgctaccaa 1867381 tgtttgcaat ccattgccgg ctgaatctac agatttatca atgaatttca tctggtctaa 1867441 catcttgttg acggacttag agcctatttc agccttgtct ctcatcgaag aagaaagatc 1867501 cgctatgttc cctgtatttg aagcgactga tgatatactg tctaataatt cagtgatgga 1867561 ttctgcgctc ttttctgtca ttgagctttg cttcacattg ctgtcggcag ccatctgcat 1867621 ggctcgtgaa atatgttcag atgttgattt cgattcttcc gcgcttgccg ataattcttc 1867681 agaggaagcg gcgacttgtt cagatgagct gctgatctgc ttcacaattt gagttaatga 1867741 atgagtaaaa gaattaaaag attgggcaag ctggccaaat tcatctttat ttttcacaat 1867801 gacttttttg gttaaatcag cctcgccgtg tgcaatttcc tccagctgct tatttatgct 1867861 tcttagtggc accataatgg actttaacag cattatgctt agaacaatgc ctaatattac 1867921 tgatatccct gtgacaatga taatgagcga ttgactcatt ttcccattgc cctgtatttc 1867981 atcctttaga tcctctacct cttgatccag gcgatcagac agcttattga cagccggagc 1868041 tacgccttct tttcttattg ttctttcttc tccaaaatgg atggtttctg cttttttagg 1868101 atttgaagag taggctgtta ctacttgctg attcaaagct ctatactgag taaaacttgt 1868161 cttaatgtct tcaatattgg attgatactt ctcttcatca atcaagtcat taacccggtc 1868221 aaggctcttt aagacatcgt ctgcttttcc cttcataccc tcgtcgtatt ctttgtctct 1868281 ggtaatcaag aagcctcttt catcatttga taacccggtc aattcatatt ggatgtgttt 1868341 tatctctttt tggaattcca ttttgtcttt aagttcttca ttctttttca cagtagaaga 1868401 aatcataaat actgaggagc ctccaattcc aataattgaa acaactaata ttgatataat 1868461 ccccagcaat tttgttttca ctttcatgtg tcgttttccc tttccgcaca atgtaatggc 1868521 tgaaataaaa tatgttcaag cgcgtttgaa tccaattcgc ttacgctcat gtccataata 1868581 tcgacacgtg ttatcaagtt ttatagtgat attcttatat gaataagcaa attctttacg 1868641 tctctgaact tacagaaaaa ccttaagtaa aatttgcagt cttttgcggt atgtaagtca 1868701 ctcttattcg tttttctaaa aaaggctttt cccacctcaa attggctgaa ccggctgttt 1868761 tctcgaaaat ataatacaat acgcagcata atatgaagga gcgaaactta aatggggatc 1868821 atcaatggta aagaattcat tgaccgattg aataaactag aaaacgaaat atggtatgat 1868881 ggcgaaaaaa taaagggtaa catttctgag catcctgcat ttaaaggaat aatcaaaaca 1868941 aaaagctcac tttatgaatt gcaaacaaag gatgagttaa tacatgaaat gacttattgc 1869001 cttcctggag atcataatcg aatcggcctt tcctatctcc agcctaaaac aaaaaatgat 1869061 ttgaaaaaaa gaaggaccat gattgaacat tgggctagac atactcatgg aatgatgggg 1869121 agaagtccgg attacatgaa tacggttatg atgagctttg cttcgtcagc ggagcttcta 1869181 aaagataaag agaattgctt tcctgaacat atactagata tgtatgaaca agctgctaag 1869241 catgaccttt cctttaccca tacattcatt actccgcaag tgaaccggtc acagtcctat 1869301 tttgggctaa gtgaaaaacc gatatctgct aaagtcattg atagaaccga aaaaggttta 1869361 atgattcatg gcgcacgact gcttgccaca caaggcgggt tgaccgatga aatcttggtt 1869421 ttttcagcgc ctaaattttt ctttgaaaca gatgaagctt atgctttttc aatcccttct 1869481 aatacaaaag gcgtaaaatt catcacaaga gaatcatttg tattaagcga ctcttccttt 1869541 aatcatccct taagctcaag gtatgaagaa atggattcaa ttgtggtttt tgatcatgtg 1869601 ttagtgccgt ggaatcgtgt gtttttttac gataatgtgg aagcagctaa agattttatg 1869661 acaaaaagct cttttcatgc ctttaccttt caccaggttg tcattaggca aatgataaaa 1869721 attgaatttc tattaggtgt tgcacagctt cttgtcgaca ccattaatgt ttccgaatat 1869781 cagcacatcc aagaaaagct ctcagaaatc attgtgggat tggaaacaat caaagccctc 1869841 attgacaaat cggaaaatga tgctcagtta gatgaattcg gctatatgcg cccctgttta 1869901 attcctcttc aagtcatcag tacgatcatt cctaagctat atcctcgatt tactgaaatc 1869961 atacaattaa ttggagctag cggaatggtg acactgccta ccgaaaatgc atttgactca 1870021 gagatacggg aagatcttga ccaatatctt caagcaacca atacaaatgc tgaagaacgt 1870081 gtgaaaattt tccgtttggc atgggattta acaatgagtt cattcggaac tagacaaact 1870141 cactacgaaa gatatttttt cggagatcct attcggattt caagcaggct gtataccagt 1870201 tatccaaagc aggagcagtt gaacatgatt aaaacatttt tacatgcaga tacagaacat 1870261 tgaaaaaaca gcgggaaaag atccgctgtt tcgtattttt tattcaggaa actgaacatg 1870321 gcccggtact gtataggctt tggacgttcc gctttcaggc agctttggaa tggtgtcttt 1870381 cacaactttt ccgcggatgt cagtcattct gactttgaga gagccagtac ctaaattcgt 1870441 actcacaaaa tggttatagt ccattttctc catgttgatc cacttaccat ccttttcata 1870501 ttccattttc ataacaggat acttgtgatt tctgacttgg attgctgccc accacctgct 1870561 gctgccttct ttgatccggt acgtgaaatt gccggtgatt ggggctttga caacacgcca 1870621 tttaatattg atttttccgt ctttcatatt gccgatttta cggaaggcat taggtgacag 1870681 atcaagagct ccccgagcgc cttcgggata aagatcagta acatatacgg ttgttttccc 1870741 ttttggccct tcaacttcca aataagagcc ggcaagtgcc gcttttactc ctccgtaatt 1870801 gagatccgcc ggatttattg cagtaatctc catatcggaa ggaatgggat ccagcaggaa 1870861 agctcctcct gaatagcctg accctgtata cgttgcataa ccttcatgca ggtcgtcata 1870921 tgctgccgaa gcttgcgggg aaaaacagaa gatcgtcaac aaaaccatac caacaaatgc 1870981 actcatgatc tttttcatat ttggtcctcc tcaaaccaga cttcaaatga gaatcattat 1871041 cattataaga ctcaatccat ctggtttgaa agaggaaata gattcatagt tgattttaag 1871101 gcaaattcac tatcattcat atatcaaatg taggtactta tgaaaaagcc aatacaaatg 1871161 aacgaatgtg cacttcagcc gaatgtctta tttttccctc tcaaaattcg catttcaata 1871221 acgaaatgaa acaggctgtt ggcctgataa cagctataca ggaaaagcta tttttccccg 1871281 ctcagtttca acttagctgt catcatgatg ccaaagatca gcacaatcgg aacccaaata 1871341 atgaagtgat aaaaatcagg ctcagccaga gcaacaataa tagcccctac acaatacaaa 1871401 ataatagcca gtgctcttaa cacagtatct cttaagaaag tcttcttttg cttcttaaaa 1871461 aacaaacggc cggatatatc ctctaaaaga gaagccaaag tgccggtcaa cacagttgaa 1871521 gaaatacctg caatccccag tttttttgct gctgtagttt gaatccccat agaaatgctc 1871581 atgagtataa ttagaatgtg cacaggaaca aatgcccggt aaaaagaaag acaagcaaag 1871641 acaaacaaaa tgaatgcttc aagtgcgagg gcttttgtca cagcagaagg ccaaagggta 1871701 ttttccgcct ttccgaccat caatgtagca atgatcacgc cgcatataaa tccgattagc 1871761 gcagtcaagg aattaaaaac agtgacctga atggatttgc cgatagctaa ccccaataat 1871821 acaatgtttc cagtcatatt agctgtgaac acatgtccca ggcttaaata cccgattaca 1871881 tccacgattc cagctgttaa acataaaagt gatagcaagg tgtttcgata agctgctgca 1871941 gtcaacggtg tatcaatcct ttcttctatt tcaattgtta gtatgtcttt tggcgcaatc 1872001 tctatttttt aagtaaccca acattaatta ggaagataga acctattatt cctttccatt 1872061 aactgtaata ataatccccg caaggaaatg attaaaattg aaaggaagca tattgtgatg 1872121 aaacgacttt gtttatggtt caccgtcttt agcttgtttt tggttctctt gcctggaaaa 1872181 gcattaggtg cagtcgattt tccgaatacc tcaacaaatg gccttttagg ttttgccgga 1872241 aatgccaaaa atgaaaaagg catctctaaa acgggcacaa cgggtggaaa aaacgggcag 1872301 attgtttaca ttcaaagcgt aaatgattta aaaacccatc taggaggatc cactccgaaa 1872361 attttagtgc ttcaaaatga tctttccgca tctgcgaaaa caacagttac cattggctca 1872421 aataaaacac tcgtgggctc ttacgcgaaa aaaacgctga aaaatattta tttaacaact 1872481 tcatcagctt ttggaaatgt catttttcaa aatttaacgt ttgaacacag tccgcagatt 1872541 aacggaaata atgatatcca gctttattta gattccggta tgaactattg gattgatcac 1872601 gtcacattct caggtcatag ctataatgca agcggaagcg atttggacaa actcgtgtat 1872661 atcggaaaat ccgcagatta tatcacgatc agcaactcaa aatttgcgaa tcataaatac 1872721 ggtttgattt taggataccc ggatgattct cagcatcaat atgacggcta cccccacatg 1872781 acaatcgcca ataattattt tgagaacttg tatgttagag gcccaggtct gatgagatac 1872841 ggttactttc atgttaaaaa caattacagc aataatttta accaggcgat tacaattgct 1872901 acaaaagcaa aaatatattc cgaatataat tactttggga aaggcagtga aaaaggcggc 1872961 atccttgacg acaagggcac tggttatttc aaagacatag gcagctatcc atcactcaac 1873021 aagcaaacct ctccgctgac ttcttggaat cctgggtcaa actatagcta tcgtgtccaa 1873081 acgccggaat atacaaaaga atttgtcacg aaatatgccg gatcacaaag tacaactctg 1873141 gtatttggct actgatataa aagaggccct gcgttaaaaa cgctgtgcct ctttttatac 1873201 tataggctat ttttaagcga tccttgtaat tccatcaaga tccagcgtcg gtcaaactaa 1873261 aaagcatatg ttcttttcca caataacttc ttaactggct ttcttattat accagtttat 1873321 cgcaagtgaa aagaaatcat tgttctgaac ctgtattaaa tgaacgatcg tcccacaaac 1873381 tacttaaaaa cccctaaaaa ggatgatgga tatgtgcggc aggtttactt tgtactctgc 1873441 atttgatgat attattgacc agtttgacat cgatcaattt tttcctaaag gtgaatacca 1873501 gccaagctat aatgtcgcac catcacaaaa catccttgca atcatcaatg atggatcaaa 1873561 taatcgctta ggcaagctta gatggggact tattccacct tgggcaaaag atgaaaagat 1873621 cggttataaa atgatcaatg ctcgagccga aacaattacc gagaaaccgg cctttcgaag 1873681 accgcttgtc agcaaacgct gcatcatacc agcagacagt ttttatgaat ggaaacggct 1873741 tgattccaaa accaaaatcc caatgcggat caaattgaaa tcatctgctc tttttgcgtt 1873801 tgctggctta tatgaaaagt ggagcacaca tcaaggatac cctctttata cctgcaccat 1873861 cataacaact gagcctaatg agttcatgaa agatatacac gaccgaatgc cggttatatt 1873921 ggcccatgat catgaaaagg agtggcttaa ccccaaaaat acaagccctg attatctgca 1873981 aagtttgctg ctgccttatg atgctgatga catggaagca taccaggttt catcattagt 1874041 aaattcaccc aaaaataatt cagctgagct tcttgatgca gaaaatcata tgtagtgatt 1874101 gaaaaaattc tctagcaaga acttgtcaaa tagctttgtt ccttaggtgc caatccctct 1874161 agtaattatg aatatttagt acatagatca attagttatc tttagcatca gtttgaaata 1874221 attttattat gtaaacttaa ataagcaatg ttattccttt catataaaat agtttacatt 1874281 tttataaaat cgcttcactt ttctattttg tcagcaaaaa aactgaacca cattaaactt 1874341 atgaaacctg ccgcacctgt ggattgcaaa tatgatataa gcccatagag gtaaatccat 1874401 acactttccc tcctaagaat taaatgaaat ttctttcatc ttacatgaag gtcttctttc 1874461 ttttgtttat ccagtgtaat acttaataat atgttgatga atgcagctgg aaaatatata 1874521 aatcccactc caagaatgcc tagtatcgta cttaaactta ctatgtaatt ctttgtcatc 1874581 gtttgactgt caatcaatat tagaagtgaa atcaatccag ctaaaacacc tataaaccaa 1874641 gcatcgccaa cagcataaga atcatccagc atccctaacc atcgccccaa tatagagctc 1874701 ccaatggcag tcaaactgga taaaaatatg agtgctttca tttcttctcc tcctttaaag 1874761 ccaatcaaac tggtagaaat cggccattga atccccatta tcgaatggtt accatttcat 1874821 ttccacatta acattttaaa gctcattaca atacgattca agcagaaaaa ccctacataa 1874881 cgtatatata gggatttaat aaaacacagg ccaaaattca gctctatcta ctttaaaaag 1874941 atatgaaggg cagctgtgtg atctgttacg tctttacgta ccgggatatt tcacaacagg 1875001 cactttcttc ttgcgcagag aatcaagcat gactgatcca gcattcaagt tgctttgtac 1875061 taattcttta ggcgtcaatg ccatccactg attgagtgac acatctgcat agcggttact 1875121 tttgaacatt tctaaaaacc ataatgtttc tgtaccagtg ttttgtatat agtgtccggc 1875181 attagaaggc acgtatccaa cgtcgcctgc tctataatca aatgtgcggg cagtcccatt 1875241 tccgataaat accgtcattc gtccctgtcc tgttagataa tattgccact catcgctatt 1875301 gggatgccaa tgaagctctc tcatcgcgcc aggctcaatc tgaacaagtg cagcggctat 1875361 cgtttttgaa attgggaagt tagaagaatc cacaattcgt acactccccc ctggcatttg 1875421 aattgggggt tgatttaaca gctcgtgttt aaaggtcatg gggacttttc catatggtga 1875481 ctgaatgtct tcactggcga ctgatcccgg cacattccct tggtagatat agacttgctc 1875541 agacggaaga gagttgaaag cattctccgg gacaccgaaa tttgcagaca gaacatcttt 1875601 tggtgtgtgt gcaagccaat ctgaaatggt taacgttgaa aactcagaaa agttcccatc 1875661 atcgaaaacg agcagaaact cgcagtgttc caatccctgt atggaatgcg gaattcctgc 1875721 cgggaagtac caaaggtcgc cgggaccaac atcagcaatg aaatttcgtc cgtcttggtc 1875781 aacagcggtg atacgtgccc gtcccaaaag catataagcc cactccgctt gcttatgcca 1875841 atgaagctcg cggacgcctc ccgcagttaa gctcatgttt acacctgcaa tcgcagtcga 1875901 aatcggaagc tgtcttacgg tgatttctct tgaccagccg ccgtgatcta atttcatggg 1875961 agcgtctgag aatgaaaatc tcaagttagg aatcataccc tcatctgtaa caggcggaac 1876021 aaatatattc ggattttgaa tatcccgtat tatatttcgc gggcctgtat caatagctcc 1876081 agctccatca cttcgaatag gctgcggcac gtttctgtct tcatgattga ttggttgttg 1876141 ttccaacagc atgcacctcg ttttagaaat gaacaagatt ttatttcagc ctatgcagaa 1876201 tcttagattg ctgtgcctag gaatccgcaa ataaaaaagt gaccaccaat gtgatcacaa 1876261 atacatcaaa taaactattt tttataccat ggcttcttat gtaatttgat tgcttctgtc 1876321 tgttttttct ggcctgtcct ccactccact tttactaata catcatgacc tatcacttca 1876381 tcttcaggca tataatcaaa ggtggaaata tggtcctcca tgcgtccccc acccggcatt 1876441 tcatcacctg tgtactccga taagtcgtac tcatctacgt tatcatcttg atacttttcg 1876501 ccatctacat acagagtaat tctttcaaca acagtccact tttcttcctt cttactcccc 1876561 tgccaatata gatttagaaa ataattgggt ccaattgaag ttttgtctga tttttcaagg 1876621 ttagacatcc acagtccgct tttcccgctg ccctcatatt tcactttgtt ccctgacacc 1876681 attacaaata atgtgatgat gcagatgatc aagaatccag caatgatcaa tagccatttc 1876741 ttaatattgt tcttttttct catgtttttc ctcactttcc taacttttta gtaggaaaat 1876801 acgatcaaaa tgttaccgaa aagaaaataa gaaagggcta atgatctaac agatgactgt 1876861 ctaaactttt gacttaaatt aaagtgcttt ctaaagacaa gattaaaacg tataacagct 1876921 cttaaatgca ttttttgttt cattgagtca agaaccttaa aatggctttt tattattaaa 1876981 aatcaagcta gtgtattaag taacttttca aatttattta tactcatgat ctcgtgagtc 1877041 acaaatctcc catcaaaaaa aacgctaaaa gttgtccaaa tagctggtga cttttgtgcc 1877101 tcttctttcg atgataactg aattgactga aattgaaccc ctttcttttc agtcaattcc 1877161 cgcaaatcat ttatcatgcc cactgcaaac ggacactgag ctgtatagta tatcgtaatc 1877221 cccttttcat tgatagaatc acttttcacc tggctcttaa atgcaggaga atctgcaagg 1877281 ccattccaag tcaaagccat taattgaaaa taaggggcag cttcatcttg tagagtaaac 1877341 cccatatgct caaagaaatg cttatcactt aaatagggca gttttttctt gcctgcgata 1877401 tggataatgc catccatgcc gcacgctttc gcatctgcta tacatttgtc caacaatcgt 1877461 ttcgcatgac cgttattttt atatctgcca gacacccaca gacaattaat gtacataaaa 1877521 ttaggcgcat tgataggcac ccatgcctca ttcgcaggta ggtattcaat aaagactttt 1877581 gcccgttcat gtaagcgata gaacaccaat ccttcatcca ttcgagcttt gagccatctc 1877641 ttcttttcat taactgcatg ctcatattgt ttcgtgctta atgcacagca aatatgattg 1877701 tcttcaatat tgtcctttgt gatttcaatg tagcacatct cctctttccc ccctttaaca 1877761 taattacatg gaattcaact tcacacttta catgcctaat agaataaata cccgttccaa 1877821 cttaaatact ttttcttttc cattttgcca attaactgta aaacccttct tttattcaga 1877881 tattatcttg attcctatat cacccatttc aaatccaaag tgtgttcatc tttgaggatt 1877941 agatgcactg cttatgctat aaatacagta cacgaagttt tttatttgaa gtaatatttg 1878001 ttacgggaca gcaatagtaa ataagtgata aaaggggaat taaacttggt ggaaaaatgt 1878061 tattcttgtt taatttgcgg atacaaagga ttaattcaaa atcctttgta taaaggcgag 1878121 tatcaaaaaa cgtttgacat ttgtccatgt tgcggttttg aatttggcta cagtgaggat 1878181 catgatgtga ggttaggttt tattgtaact cctgatcatt taattgaggc tgcatttcaa 1878241 ttgtatcgca aacaatggct tgagagcggg atggtaattg ctcatccgga agatattcca 1878301 gaagaattga aaaatggcaa ttgcttaaaa tttgaagttt tgttgaaaca attgaaaaaa 1878361 ctaaatcttg acatagaaaa ttttgaaatt agcggttttt aatgatgaaa caggttgcac 1878421 ttgtttaggt ttcactgtca ttatcagtaa aatgttaagt tgaaatgcgc aatcagtcac 1878481 aaagtctcta ttcgtattca ataaagactt tgtgatcatc gacaaacatt tcactcccat 1878541 cggataaagt atccaaaagg cctcctctgg ttcttctcta tagtcattaa tcacagtcac 1878601 tttgacattt gactcagcta tgattggttt tccaacaatt tttcgttttt tcctcaggca 1878661 aagtaagaga tcgaatcatc aaagccattc catctttact gtctaattaa cgccatcttc 1878721 agtgaattta aaggtctgtt ttaaattgcg tccttcttgc cccttctgtg tccaaattat 1878781 aacaacctct aattcagagg ccttatctgc cagcataaaa tgattgaact tcagcggtga 1878841 gccatcattt aaactttcag ctaacatttt agaatcttct tttggtttga cacaattttc 1878901 atcgggacat ccaaaaagcg aaaaccttgt gattgaatta gggtcatttc tatacaattg 1878961 cacatccact gtagctgctt tttcccctat atttttgact tccaaggaat atacttgata 1879021 ttctccttta tgaggtctcg taaattcctt tacatttttt gcttcactta cttttactga 1879081 ccactggtct gttttttgtg taataggcaa caccgtaaaa gtcagggcat gcgcttttga 1879141 ttggcaaaac gtaaatccaa ctgctgtaaa aacaattaca gaaaataata cccttttcac 1879201 ttcatttatc cctccttcct ttcactggcc gctccttaaa gaattgattt tgagcaatct 1879261 acaagctctc ttaaccaaaa ccttacctga ggttttgtct ttactgctct gcatttattt 1879321 ctttcggtat ccgagaagga gctttgggga tttttctcaa tctgctgtta atcacatcag 1879381 aagagtatag cgtaataatc atacttcccc catacctttt tgcccgaatt aagattggtt 1879441 ggttatattg gttttgaaag cgaaagtcag gacctcccca gcttaccgtc gcatcccgtc 1879501 cgggcggtac atatggtaca cttctagtat gagaatagcg ctgaacgatc tgcagtcctg 1879561 cacgatctac tgcattaaat agagttgagg acacctgaca aattcctcct cctacacctt 1879621 cagacaactc cccttttaca ataatgggtg cacttttata tcctttgttc cgagttctca 1879681 ttcccacaac ttggttaaac gaaaacgtct cattagggaa aacaacgtga ttgtcgattg 1879741 cttttgcaga aagagaaata ttgtgtgaac ggcttttatt gcttgagtta aaatacgtca 1879801 cgtactgacc aagctgctgc gtactgatgt gagctagcag ctcgctgtca actttcggat 1879861 aaatgttcat ttccggcact tctatcttgg agggaccttg cccataaaaa tacgcataaa 1879921 acttttccat aaacgcctgt tgatacagtt tgtagccaac cctgcccggg acgatgcttc 1879981 catgatcgtt aaggacagca tttatcggct cacggtacac tttctgatca agctgtttga 1880041 tgaatttact gtatttttca tagtcaacca ttggagtgcc gggaagaggc attgtaaagt 1880101 cttcacggtt aacagtggca atcgtccgtc cttgctgtgt gaccgttaaa ctgtcctgcg 1880161 gctcactcgg ctgagccaat aaaaaaagac cagtgatcaa aatttgtatc ataagtcggt 1880221 ttacctccca atcattagta tgaacagccg cttatccttt gatgtatttc ttcccatcgt 1880281 ttgtttgaat ctttagacgt tgataaaaac cttcataaaa gagcttagct ttatgttcac 1880341 accgatccct gagctcactg aggcacacgg ttcattcagt cggcaagttt gaagtagttc 1880401 agcatctccc agtgatgagg gatgcttttt tgtcttgtca aaaatgaaaa gggtctccta 1880461 taacaacaaa aaatcaatcc atttcaatat ttttttattg agaaacgata aattttttgt 1880521 tacattcaat tagacaacaa ataaatgagg tgcttgttat gaatcgaatg tcgacaattt 1880581 ttttaaagat agctttggtt cttattggaa ttccaattct tgctttatgc atttttttag 1880641 tgcctaaggt agccaactat tcagcagaat tatttccaaa tatcgcttat ataaaatatc 1880701 tcgttttcat ctatttgtat gtaacggcga taccttttta ctttgctctt tatcaagcgt 1880761 tcaaactttt aagctatatt gacaaaaaca aagctttctc gggtttgtct gtaagagctt 1880821 tgaagaatat aaaatattgc gcagtcacta tcagtatctt ttacgcagca ggcatgcctg 1880881 tcttttatct gatggccgag atagacgacg ccccgggtat cattgtgatc ggattggtta 1880941 ttatttttgc ttcaatggtg attgcggtct ttgctgctgt tcttcaaaaa ctgttaaaag 1881001 aagcgattga tataaaatca gaaaatgact taacggtctg aggtgatgac atggcgatta 1881061 ttatcaacat tgatgtgatg cttgctaaga ggaaaatgag cgtaacagag ctttcagaga 1881121 gagttggcat caccatggct aatctttcga tattaaaaaa cggaaaagca aaggctattc 1881181 gattatcaac tttagaagcg atttgcaagg ctttagaatg tcagcccggg gatatattgg 1881241 aataccgaag tgatgaagac acaggattcg taaagaaaaa atatgaagga tcaacagaaa 1881301 aataaagtga ttggcggtga gcttatggac ataaacttat atccatctag ctgctatact 1881361 aagcgtccct ttcatacacg aagaacacaa ctatggagga ggcatacatc atgagagcca 1881421 taaaacaaat cgtccatttt ggctgggaac aagccctttc atgtttgttt cctgccgtta 1881481 tttttgcctc tttggctatt acgcaaatca tcccactgcc cttcttgccg cggtatgact 1881541 ggctgctcat tatctgcgtt ctcatgcaat tgtggatggt gcgttccggt cttgagacac 1881601 gggatgaatt aaaagtgatc acattattcc accttattgg gcttgctctg gaacttttta 1881661 aagtccatat gggctcctgg tcttatccag aagaaggata ctccaaaata tttggagtac 1881721 ctttgtatag cggctttatg tacgcaagtg tagccagtta tttgtgccag gcatggagaa 1881781 ggcttaaggt tgaactggtt aagtggccgt ctttttttgc agttgttccg cttgccgcag 1881841 cgatttattt gaattttttc acccaccatt tttctataga cattcgatgg tggttatcag 1881901 ggcttgtcat cattgtcttt tggcaaacat gggttacata cgaggtgaat ggagctcgtt 1881961 accgtatgcc gctcgcactt tcttttatac tcatcggatt ttttatatgg atagcggaaa 1882021 atatcgctac gttttttgga gcttggaaat atccaaacca aatcgataca tggagtctcg 1882081 tacaccttgg aaaggtaagt tcatggctct tgctagtgat tgttagcttt cttatagtag 1882141 catcattaaa acaagttaag gagcagagtc ccacaaaggc agagatggat gaatcttttt 1882201 cttagcatac gcatacaagc tcccaaatag agtgaaaagc aacgttcaaa tggttgcttt 1882261 tttcttttat gtaactctgc cggtgagtat tcatcttctt caaatttcat cgcaacacga 1882321 taactgattc agattacaac tgctttcaac actttgacaa actcatgcgc cgccggcgtt 1882381 atctcttcaa atgaatgtgc gatgacgcca atatcgcgtg tgaccctagg aaagatgtcc 1882441 tttttaatca attgatgcgg gacggatgaa agtgtaaagt ttgaaatgat gccgataccc 1882501 aagttatttt tgaccatatt aatcaaggtt tcggcatttt gcacagttaa gttttccttt 1882561 aattcgatgt tgtattgcga aaatgcgttt gacatcgcga tttcatgacc gcctttacaa 1882621 aaaatgaggt catcttgata tgtttcaagg tcgacatgct tttcaagttt taattcgtca 1882681 cgctgcggcg ggatgacggc caccatatag tcgttacaca atagctgatt ttcaaacggt 1882741 tcaaatggag atgctgcgat cccgatatca accgtccgat cttcaaccca tccttttatt 1882801 tggtcagagg ttccttcgat caattctatg cggatcagcg ggtagtttga tctgaatgcc 1882861 gcaatcgcct gtggcatgat atttgttgaa actgcaggaa atgaaccaat tttcaccttc 1882921 ccgtttaaca gcttgttttc ccggttggct acttgatata ttttgctttc aattcccttc 1882981 atttgcctcg ccagcagcaa tatttctttt ccgatgtcag tcagcattaa accatgatgt 1883041 ttatccctga tcaataattt gagctgcagt gagctctcca ggttttttat cgctttactt 1883101 accgccggct gagagatgaa caattctttt gccgcttctg taatatttaa tttctcccca 1883161 acttttacaa atatgtgaag atggttcatg ttcataacca tttggttata cccccaataa 1883221 taaaaatgta tttcagttat acataaatgt aacatatgat agaaaccagc acgatatttt 1883281 aacaagaaag gcggcttcat tatggtaaaa gttatgctgg gaatcatatc tgtcacactt 1883341 atttggggtt atacttgggt tgcgatgaaa gtaggaattc atgacatccc cccgctttta 1883401 ttttcgggtt tgcgcctgtt catcggagca gttcctttat ttctcattct cttcatccaa 1883461 agaaaaaagc tttcaattca aaaagaacat ctcaaaagct atatcatcat gagcctgttg 1883521 atggggctgg gctatatggg gattttgacg tatggaatgc agtttgtcga ttcagggaaa 1883581 acctctgttt tggtatatac aatgcctata tttgttacgg tgatcagcca tttttcatta 1883641 aacgagaaaa tgaatgtgta taaaacgatg ggactggtct gcggcctctt cggactgtta 1883701 tttatatttg gaaaggaaat gctcaatatc gatcaaagcg ctttatttgg ggagctgtgc 1883761 gtacttgtgg cagcgcttag ctggggaatc gcgaatgtgt tcagcaagct acaattcaag 1883821 catatcgata ttattcacat gaatgcctgg caccttatga tgggagccgt catgttattg 1883881 gtgttttcct ttatatttga ggcggtccct tcagccgagt ggacatatca ggcggtgtgg 1883941 tcattgctgt ttaatggctt gctttccacc ggctttacct ttgtcgtatg gttttgggtg 1884001 ctcaatcaaa tccaagcgtc aaaagcatcc atggcattaa tgtttgttcc cgtattggcc 1884061 ctattctttg gatggctgca attgcacgaa cagatcacca tcaatattat cctcggcgca 1884121 ctgctgatat gctgcgggat ttttatgaat acatttacat tttcacgacg gaaagtgtga 1884181 atgatataca tttcccctgt catttgggct tcatgtgaca ggagaagact attacgagaa 1884241 agtcttctag aatcctgacg acagcctatt aaacaatgaa aaaagctaat gtctgcatgt 1884301 agacattagc ttggctggcg tttaggctgg tgagaatcca gatacttttt tattaccatt 1884361 ctggctgatc aaactgaaaa ccgtatagac cttttacttt aacatctccg caatctggat 1884421 cttttgtcaa aatcaaataa tgagtcttat aaggcatcgt ctcaactcga tcagttgcac 1884481 taaaatcaaa atgatccccc gagaagtttt tttcactaac ggttatttca tatcctgaca 1884541 aagtcattcg catgattctt gcgttaattg tacatccttc agtatcgaaa atggtgaatc 1884601 tgtacccaaa gtgagatgtc caatggtttg aatttaggtc atcagacttc ataaaccatt 1884661 tttcattctc tgtcattgta aaactcactt tctcctcatc tttcacgata acggccgaag 1884721 cttcccctac atggatagtc aaagccaaaa gaaatgtaaa agctaacatc aacatctttt 1884781 tcaaaagagt tcctcccgat atcttttact tcaatatatt ggaagggtct tttctgatca 1884841 agacagtctt ctccaaatga atctttagca ccatgaaatg agccttaata agaacagttt 1884901 taacccaaat caacctctat tcgaaataag gcttaccaat ctatattctt tttaaaagtt 1884961 tctgcatttc tttatttagc tcctagacac atataaaaaa tgctcctata agttcaggag 1885021 cactacaaaa aactgctaaa gtgttttcta tcgatttatt gtattcatta gctcaaagaa 1885081 atattcaggc ttttgagtct tatttagctt ataccatgaa cgcaatgtat ctggtgcaaa 1885141 tacatctaat tttttcaata cttctaccgc aaattccaga ggagcaattc ctgatgcagt 1885201 aaccaaattt tcatcagata ctgcaggccc cttttcatag aatgtttctc ctttgtaatt 1885261 agggcagacc atattcatat agtcgaggtc attgcttgtg tgctttctcg aatttaagta 1885321 tccttcattc gcgaggccca aggttgcccc acaaattgca gcaatagtcg tgccgagctt 1885381 taaagcgtcg ccaacttttt tcaagatcgg ctgatgaata tcttctcccc aagtgtttcc 1885441 tccgggtaaa atgataagat cttgactccc aagagtacat tcgtcaagag aaatatctgg 1885501 ttttatgctt aatcctccca acgtagttat catttcttta ttaaccccta ctgtaactac 1885561 ttttaaagat gctgcatctt gtttaaagta tctccctgag tttagttccg caattaaata 1885621 tccatattcc cagtctgaca ttgtgtgaaa tacgtagaga taaacttttc tcgtttgcat 1885681 ccaataacac tccaatcaca attgataaag ctttctaata gatgactttg ctgacagtca 1885741 ttgtcagctt ttttgttgat tctattctta tgcccttgtt ctcccaactt ataaaaatat 1885801 aagatcaatt gattctatgt ttactagcgc aaaggggttt gttacactaa ctgtcatggg 1885861 aaacatttca aaggtaatac aaaatcattt gaatgaggag gcctgatgaa gttgaaaact 1885921 aaagcgtcaa taaaattcgg aatatgtgtt gggcttttat gtttaagcat tactggtttc 1885981 acaccttttt tcaactcaac acatgccgaa gcaaaatcca tagaagacac aaacatggca 1886041 agctgtataa cgaataaaaa atttgttcaa cttgagaaaa aatttgatgc caggcttggt 1886101 gtttatgcaa ttgatatagg ttcaaacaag acaatcgcct atcggccgaa tgaacgattt 1886161 gcttacgcat caacctataa agttctagcc gcagctgctg tcctgaagaa aaactcaatt 1886221 gaaaaactta atgaagtcat ccactacagc aaggacgatc ttgttacata ttctccaatc 1886281 acagagaaac acctagatac aggcatgagc ctaaaagaaa tctcggaagc ggctatccgt 1886341 tacagcgata ataccgctgg gaacatcttg ttgcaacagc ttggcggccc taaaggtttt 1886401 gaaaagtcac tgaaacagat tggggatcat gtaacgaaag ctaaacgatt cgagacggat 1886461 ctaaactctg cgattcctgg tgatattcgt gacaccagca ccgcaaaagc actggcaacc 1886521 gatcttaaag ccttcacttt agataacact ctcacgactg acaaacgcat gatcttaacc 1886581 gattggatgc gaggcaatgc tactggtgac gaactgattc gggcaggcgc tccaatagga 1886641 tgggaagtcg gcgataaatc cggagccgga agttacggga cacgaaacga cattgctatc 1886701 gtttggccgc caaacagagc tcctattgtt gtggcaattc tgtcaaaccg ctttacgaaa 1886761 gatgctaatt atgataatgc tcttatcgct gaggctgcaa aagtcgtcct taacgatctc 1886821 aaataatatg tttagccttt tgccacaaag gaaaagacat tactttttta acttctaccg 1886881 ttcatttttt gatgaacggt tctttcataa gacctctaga atcatatatt taaacaccac 1886941 aaaattaaac attattataa ttaacagcaa gttttcattt tatggaacaa gtaaagtttg 1887001 aatctgacaa gaattaagac taagcaccct aaaatccgtt ttcttttctt ccaagaatat 1887061 actccttagt gcaagccatt ataaagatac aagtgaacat acaatgcaga caactctctt 1887121 aagtctctta ttctgtgacc aatttgtaat actcatgaat atccggactc acttccaata 1887181 tttcgtctcg ttcgaagaca ctaacatatc aaaccacttg aattaacata actgaacttg 1887241 atattggtca ctggcagttt caatgcaata gaacaacatt tgttgtctca gaggttatct 1887301 atatgagaat tcaacaattt ttttataata attcatattt ttgtatcgtt gcacttggtg 1887361 gatttgactc ttttcgtgta tggaaccaca cttttatttt ttcacctctt ttgagatcat 1887421 ctgtgttatc aatctcactt aatcctacaa ttactatgtt atttttaaac ttgttcataa 1887481 gttgtccttc agaaagattg taatcttctt ttcctggagc ttttgtatcg gtaatgagaa 1887541 ttgccctttc attgtcttta agcacgacat agcctactag gctctgcatc tttgtttcgt 1887601 ctccgttttg ttcattttta ttgcagcctg caaggaaaat aatgagcata atgagcacta 1887661 tcaagcttac tccgatttta ggcatctttc ttcctcctct ttaaactcat ctttaaaata 1887721 aacaacagga tatcacccaa cccatctact tctttttgca attcataaca gcagcatact 1887781 cattctccaa ttcctcaacc ttctttttat tctttctcaa atatttgcat gtggtagccc 1887841 tcgatattat ccgcttactc atttttgcgc tttcaaatat attattgaag gccgcttctt 1887901 tctggattcc agcataaata tacttatcct tactgtcgtt tactatcgca acttccatta 1887961 aaatcgagat ttttactttt tttatgatcc attattcact tccaaaataa cttccaatta 1888021 caacataata tatgtataaa ttgtaaatgg agttgatgta attgaagatt aggaaaatct 1888081 tattgagttc tgctttatcc tttggcatgc taatatccgc ggttcccgca ttggctgctg 1888141 gcacttcgtc tgaggttgca gtaaaaaatg aagaatatga ttatgacact atataccgca 1888201 ttagtcctct gccaatggac ttccagccaa caatagaata caacggttat acttatacgc 1888261 ttacacgtca ttattttgat tactcaatcg ggttttacac ggctatttat acaaaagttg 1888321 tttaaactta taaaggagct ttttagctcc tttttctctt gttttaagca aggtatttct 1888381 ttctatgtgg tcccctatca aatacaacat caacattctc cagttctctt tgacacgaac 1888441 aaaatctaaa gtttggtttt aaatgctggt aataaaaaat tcactttaaa gaagtgccgc 1888501 ccgcaaaata cggcttttgt acactacgcc aattttatat tgaaaagcca gacctcctca 1888561 aagaggttcc agcttttctt aatgtgctat cgatcttcgt tagttcaacg ggaactttat 1888621 cattcggtac aaatgcagcc tcccaacttc tagttagggc tgatggcgga atatctgacg 1888681 gttctctaca cacatcagac attagaagat ttcaatgtag ccttctgtac catgaacgcg 1888741 aattcgttgc ccatctttta tcagcttggc agcattttca acgccaacaa ctgcaggtaa 1888801 gccatattca cgggctataa cagctccatg ggtcatcagc cccccaactt cggtgactag 1888861 gccttttatg gatacaaaca atggtgtcca gcttggatcg gtaaaggagg taactaatat 1888921 atctccatct tctaaatccg catcttccat gtttaaaatg acacgcgctc gcccctctat 1888981 aactccggag gaaacaggta gacctacaat cgctccggct gggagatttt ctcgtttata 1889041 ctcacctgta acgatttcac catcagacgt gataacacgt ggtggagata gtttttcata 1889101 taatgtgtac tcgtcttttc gtgtactgat gatttgataa tccagtttat gtgtgcgcac 1889161 gacttcgtga agttcttcaa aagtgagata gtatatatct tctttttcat gaataacgcc 1889221 cgcttctatg agttgttcgg cttctttcag taaagcctgc ttataaacga agtatcgatt 1889281 aaccatgccg tattttggat attccctaaa cccgctgaaa ttccggatga tatctatcgc 1889341 tcgttttgtt tctttggctt tttgttcacc atccggtaat tgcttcaatc gatctaataa 1889401 ctcttgttct ttcttcaaag cttcctgtcg cccttgctca aatttccgat ggccgacatt 1889461 aggctcaaaa tttttaatat tattaagaat cattgggaca agtgtagttg gtttttcgct 1889521 ccatcgagtt cttgtgatat caatctctcc ggtacatcgc attccgtatt tgctgagata 1889581 atcatagatc gcgtctcggg ttttgcttcc gccatcaaac ttagccagtt catccaaaaa 1889641 gttatcatct tttacatgtt gtaagtaatc aattacctct ggataaggac gaatcacatc 1889701 tgcgacgtct aatagcgcaa gacccatttc tgaagtaata ttatggggta cagattgaga 1889761 aagcgtatct gctgcgtttt tttcacctaa ccactcgttc attttttcgt taatccataa 1889821 tgaagcattc atagcagttc gaattagaac cgaacttttt gggttaaata aaatcttctt 1889881 taattcctga atatcttcca gaataaaacg aaataaatct gatcctgatt tcgtttggat 1889941 gttttgtttt aactcttcta tcgatgtttg actgctctca atcaaatcag acacgattgt 1890001 cggatcgttt tcaacttgag ccggcatatc tgcattgcct ctgctgggat ttggtgctgt 1890061 tttatcattt ggtatcgact ttatgaaatc tcgtcgcttt attatggtca taagtgcgtc 1890121 ttttaagagc tgatcgtgct gccccatgcc ttttaagaaa acttctctgc tgtcagggga 1890181 tgccagatga tgtgtgacat caacaaatag ccttccaccg gctttacgca tgggtgcaac 1890241 agtcgtcaac agaaaaaaag acaatcccag tggttttatg ggatccgtca tcatttgttg 1890301 atgaccaaca gaaatataga cgtgattttc ttggtcactc gcttcaggga tggggaataa 1890361 agtagtgatt ggacgactct gtacaatata aaaagtatcg cgggccaaac accattcgat 1890421 atcttgcggc tggccgaaat gagcttcgat ctgtcttcca atgcgtgcca gctgtaaaat 1890481 ttgttcatca gtcagtgttt gagccttttg ctgatcagaa tcgatctgct gtgtttctgt 1890541 tccgccttct tttcgtccgt agatagccat ttttttagtt gctattctct tatcgatgat 1890601 ttgcccatcc tgtactttaa aacaatcggc agataccaag ccagaaacca gtgcttcacc 1890661 aagtccaaaa ccggcatcga tggataacac ctttcggttg gaggtaatcg gatcagcggt 1890721 aaataaaatc cccgaagcct gagggaaaac catcctttga acgataacgg ataaatagac 1890781 ttggctgtgg tcaaatccat tttgcatacg gtaaataacc gcgcgatccg taaataggga 1890841 cgcccagcat ttactgatat gctgcaagat tgcatcgacg ccggtaatat ttaaataggt 1890901 gtcttgttga ccggcaaaag aagcatgtgg taaatcctca gcagtcgcac tagaacgcac 1890961 ggcataggca tgttcctcgc caaactggga gagatattga gccactgctt tcacaacatc 1891021 ggaaggaatg tctacttcca taatgatttg ccgaatcttc cggctgatgt taccaatctg 1891081 atctcggtcc tcaactttta gcatggtcaa ttgatccaac aacacttgta acgtttcgtt 1891141 ttgttcgatg gctttttgat atcctactgt tgtgacacaa aatccttctg gtacttgtat 1891201 accttgaatt tttgataatt cccctaaatg taaccctttt cctccaacga gcgaaagctg 1891261 tgttttttca atttcatgta aaccgagaac caaagaactc attctacatc tccccttcaa 1891321 aaaaaaatat tgacaagagc ttcctagcag gatataataa aattataaga tggatatcta 1891381 taacttttta actagaaagc gcacgtagtg tgattatatc accgtgtctg tttttgtgca 1891441 atataaaaag aacctgggaa atttcaccag gttcttttct taatttccat agctagtcgc 1891501 attaaaaaac ttggtttgag ctgattcaat cctctaagga aatcctaaag ttgggttctt 1891561 tttgaactta cttgctttgt tcgtagagtc cccattcata aattggactt tttgttctta 1891621 acagtcccac ctttaactag tataaagtta tgaggatctg gttaactact agatattttt 1891681 attttgaata aggcttatgt ttgataaaga agggttatgt aaaggtgtct gttgtgagca 1891741 agcgctgact acaaaaaatt gatagcattc tcatttaaat accattctat taacctatag 1891801 ggaaagtttt aaaaccagat ggagaatacc ctacctccag caattccaag gccgttcacc 1891861 tagtagaaaa caacctttaa ccattactaa cgattttaat aatcattgat tataaaactt 1891921 ctcaaggaac gatcagcagc ccgttagcta cccctgatta aggatgatct gttaccacac 1891981 tgttacgtta gaacttccac tactttgata tccttctgtc gccatgactt ggtaagccca 1892041 attactgccc agattcattc catggctctt ccatgcgttc acatgattgc tgaaagtgat 1892101 tgtagcgttg cttccggttg gtctcttcga ctggcgaaca ctccagtact gcgtaaaagt 1892161 agtgcgatcg ccatcaatgg aaggtgcgtt ataacgtgta gttgtatata tgtcatatgt 1892221 acccccatca ctttttacag tacctttata cgttccagta ggtctataag taccccatga 1892281 atccactaca taatattcta tgagaggtga tctcgtccaa ccatataaag ttaaatatcc 1892341 attgccattc ggcgcccaaa ctccggcatt atagtttatc gtcctaaatg gcgaacctgt 1892401 agtccaacct ttaccaacaa caaaatttcc ggtattagac caattaacac tgtaattccc 1892461 gccagaccca ttgacagcgt ttactatacc gcccccatca gtccaatttt gccagtagtc 1892521 tgtgctagct gcagaggcgg ttgccgaaaa caagctaata ctcattaaag ctgccgataa 1892581 tccaactaag aaattctttt taaacttaaa catatgttac ctcctataat attttttccg 1892641 actttgaggt agcactcgta tacatttaaa acattcttaa ttactaacgc caaagctttt 1892701 gatcgtcccc ttcagtataa taccacgaat tcatgagcaa atattaaaag tatttgtaat 1892761 tcaattacaa atacctagaa acacattata agtggtcttc ttccaccata tcctgatcct 1892821 tttttcgcag gatcacaatt cttgtttcta attcagatgg agtaatatct gcaatgaatt 1892881 cccattgaac catttcaaat aaaggagata tacattagag attgtgaaat tattgtagct 1892941 gccgcttgtc taatgaaggg aagcaaattt atgaagaata tgaagaactg aagaagaaaa 1893001 caattaaggt tatactaaga aagaactgct caattaaaat tattgaccaa atttgaggat 1893061 gatagcttag atcagtttta caaagaagtt gcaagatttt tatttgaaag ggctctgaaa 1893121 aagaaaaaaa agaattgaca atcagggtaa ctgtgggatg taaccgagcc tccaattcaa 1893181 aataaatatc tttaactttc tttttttatt taaagaggga ctgtatatcc ctctttaaaa 1893241 ttaagcttta gattgctgct gaaagtaata aaaattgtac ttttgatcaa acccttcttc 1893301 gctaccacaa agaaaaataa tgaattcaat aaatgcgata atagagggga taccagtcca 1893361 gcaaaacaaa atatatagaa taccttgtcc tactcttccc aaataaaact tatgtattcc 1893421 cagacccccg aagaaaaatg ctaataatgc cgctacaatt ttgttcttct tgcttaccat 1893481 gacttcctcc tagttcattg ctaccatttt taaagtaatg ctttcacatt ataatgcatt 1893541 ttccgccaga aatcgtgaaa attttgaaat tcttttgaga ttttttattt tattgagaaa 1893601 tgaaagctca tataattgaa ctagatggtt ttgggaggca tttattcaaa atgtattgcc 1893661 aaagattacg gcaattacga aaggcacaca aattaacaat ggaacagtta gctgagaaaa 1893721 ttggaattgc aaaatcaagt tacggcgggt atgaagctga aagcaaaaaa ccaccattgg 1893781 acaagttggt tattttagct agactatatg atgtttcagt tgattacata cttggattaa 1893841 cagatgatcc tgatcctaaa gtggaaagaa aaaatctaaa agagttttta gaaaaaccag 1893901 atattcactg ggatggatat aaacttaccc ctgagatatt agatcctata cggaaaattt 1893961 tgaagttggt tactgcaaac aacaattaaa aaagccctca taagggcttt tgcataaaac 1894021 aattatttca ttgaattttc tggactcatt tcaagaagtt tattcatgat gatagctaaa 1894081 ctttcaccag ctttttgtag cttctcacct gcttttatca gagtaattaa agcacttaaa 1894141 aagtccacta agctattttg atttattgca actgtttctt tataagcttt gtaagcttct 1894201 tcaaactgat caaattgcac acctttcata gcaacaacag ctaatttatc tgaaatattt 1894261 ccatatgact ctgttaaact aaaaaatctt ttgacattga ttagtaaggc aatgcacttt 1894321 aaataatcgt gccccagacc aatatgtaaa ttgcctgcag caaacagcaa atcgttcaaa 1894381 actgtgtacg gttcaccatt ccttgcaact gtctcaatcc ctttgtataa gtataataaa 1894441 aagacaaatg aatttttatc tgtggaacgc tcaggtaata aggacactat aataacttac 1894501 tttaagccaa aacatccaaa taaaaaggct ggttataatt attataaaaa tcaataggaa 1894561 ctataaatat ataaagaggg attgctatgc caaaattata tacatgttta atttgcggat 1894621 ataaaggatt aattcaaaac ccattaaaca atgatggtga gtatcaaaaa acatttgata 1894681 tctgcccttg ctgtgatttt gaatacggct acagtgaaga tcatgacgta agcttaggtt 1894741 ttattgtaac tccagattat ttaattgacg ctgcaattca gttataccga aaacagtgga 1894801 ttgagaatgg aatgaaaact gcaaatcctg aagatattcc agaagaatta agaaacggtg 1894861 actgcttaaa attcgaggtg ttgttaaagc aattgaatag cctaaatctc gatactgaaa 1894921 actttgaaat caagggattt aatggttatt aagcagatcc aagcccccat atgggggcgt 1894981 tcttattatt gtacagtcta tcagaactat ttatagaaaa actatttaat gtattgtata 1895041 aatatcactg accttttctt tctccattca acttccttaa ccctcaactg tttgctgctg 1895101 catcacattc ctcctttttg atttttgtgt atcaagcctg tacaatattc aaaaacccta 1895161 aaggatgatg aacatgtgtg gcaagttcac tttattttct gagtttgatg acatcattga 1895221 gcaattcaac atagatcaat tcttacctga aggtgaatat caccctagct ataatgtcgc 1895281 tccttcacaa aacatcctga caattatcaa cgatggatct aataaccgtc tgggtaaact 1895341 tagatggggt cttatccctc cttgtgctaa agacgaaaag atcggttata aaatgattaa 1895401 tgctcgtgct gaaacattgg ccgagaaacc cagctttcga aagccgctcg gaagcaaacg 1895461 ttgtatcata ccggctgaca gtttttatga atggaaacgc cttgatccaa agactaagat 1895521 tcctatgcgg attaaactta aatcgtcgaa tctctttgct tttgccggct tatatgaaaa 1895581 gtggaacacg ctagaaggca atctgttgta cacttgcaca atcatcacaa taaagcctag 1895641 tgagcttatg gaagacattc atgatcggat gccagttatc ctaactgatg agaacaaaaa 1895701 ggaatggcta aatcctaaaa atactgatcc tgattatcta caaagcttgt tgctgcctta 1895761 tgatgctgat gacatggaag catatcaggt atcttcatta gtgaattcac ctgagctcat 1895821 tgaatcccat taagtaccac tgccatatcg ctttatatac cacctcctct tagctaatat 1895881 gttctaagta ggaggtggta ttttgtttgt atctccaatg ctattgcatt caataaaaga 1895941 gccttttgat gacgagagct atatcactga gcttaaatta tcaagactaa aattaaaata 1896001 agggctcata catagttgat atatataata tgtattgaga cctttattga acaaacgccc 1896061 cgtttgttaa agtggaaatc tctataatta atagccgact tttaaaagtt ccaatctaaa 1896121 attatcctct aaatcggcta gcttcattaa cttctccgat atacctttcc aatctttatt 1896181 tacagacata gaatgacata tcccaaacac cttagcctgt tcagtcttca acactgataa 1896241 atgtgaatgc ctatctttaa aatacattgc ataatcgttg gcccttcttg cacttaattg 1896301 gaaaaggaag aatgttgtat gccttatagt atcagctgta ataggggcat ttaataattg 1896361 atcagcataa aaacaaattg cttcccttcc aattaaccct atatccactt tttcgaattt 1896421 ccgataagtt ctcttaaaat aatcaattgc tctctcgtat atttcgttat tgtctaatgt 1896481 gacaaccttt tttgctgtag accaatattt attgattcct ttcctatacg gaatcctttc 1896541 cgccatccaa gccttcttaa attggtccag tgataatgga acaaatggaa agcctgctgg 1896601 atcttgcaca taaatatttt cattatccat ttggtaccct agaacataat ggtcagaacc 1896661 atttaaattt ttatgattcg gatggtatgt tagctccccc atatctaaag ggcctagaat 1896721 gacagggttt tgtttgattt gctgttttaa taacggaaat gggtcatcta agtcactagc 1896781 ttgctgatgt tcttctgcag taaatccaag gatgtttaaa gcataattga taccatcatc 1896841 aggatctctc atactaaaat aaaggttttt ttcatattct atcatggcac ctaacccaac 1896901 accagttaat atctctacaa gttgaggaga tacattttct cctattgatg aaagaaacat 1896961 tgcagttgaa tttgaataac agtaatggcc atttcctata tacactaaca tcacctccgg 1897021 gtagataagt taaccttaca attttgaaaa ttgaaaatcc atattaaatt gctccgttct 1897081 cgtattcatc atctggatca tttttatcaa caataatgat cttctcgcca atctccgttt 1897141 tacgatcgac ctctacgtat tcgcgcttga tgctgctaag tgtttcgtca gccagtacgt 1897201 gaatcattac agttgagttc gctttaattt ccgtcattta ctgcaccctt tatatttttt 1897261 ttatgttttt tcaattcttt ttagattttc atattggatt tcactctttt aattatagag 1897321 gcgtgtcata cacatgccat ctaagagaga taggacaatt ttgtcttgga ggtgaaagct 1897381 aatgaatttt cttcttgatc tttttacaaa ttggactttt gataaagtcc tggattatac 1897441 actagctgct gtaatttggt ctgtatttaa atccagatca aagcagaata agtatccagg 1897501 ctatttcgag aaaatacgcc gctatagaaa tttacatccc cttctgcgat cgttatcgat 1897561 gcgtgtactt ttatcgataa cgatccatcc ttatatgttt agttaaaaac tatcttttat 1897621 ttagacttaa tgggataaaa tcttcattgt aaaactcttc ccactcagca attaagtttc 1897681 tataatagtt ttggttagag tcggttggca tagattcaat attgtcaaaa ccattaatac 1897741 cgacatctaa ttctactgtc actaatcctt ggtaaaactt cttataattc tttttaatta 1897801 ctttgaaaaa ttcaacatca aagaagtctt catattcagt tgctccactc caagaatcat 1897861 aagaggactt aacacgataa ttaaaaagaa ccaaaactaa ctcatctttc acatcttttg 1897921 atatttgctc cattaattga tttagtcctt cactggcatt aaaatctaca atgcttaatc 1897981 ggaagtcaat ccaagtaaca gcttcatctt ttaaccttcc ttctccgtct tcattcactt 1898041 caattaatac atatctgtca gccataattc cctcctaatt tatttgttta aaatcacgat 1898101 tttaactatt tatgatccat tagtcacttc caaagcaact tccatttaac tcataattaa 1898161 tatataaaat gtaaatggag ttgatatatt tgaaccttcg aaaaatttta ttgagttctg 1898221 ctttatcatt aggtatgctg gtatctgctg ctcctgtctt ggcaacaagt tcttcgtctg 1898281 aagtgatagt aaaaagtgat gaatatgatt atgacaccat atatcagctt agccccctac 1898341 caaacttcaa gccttctatt gaatacaatg gatatactta tactctcaca cgttattatt 1898401 tcgattactc aattcagttt tatacggcta tttatacaaa agttgtttaa acttataggg 1898461 agctttttta gctccttttt caccttttta agcaagatat ttctttctat gcggtctttt 1898521 atgtatgaaa tcaaatgctt tccctaattc cttctcttct gttaccgctg agtccatatc 1898581 ttatattgca tctaaggttt agtcagtcga gatcattgaa tatatagtac tttactcaga 1898641 acattttgct tattaaggac ataataagtg ttcgtattaa tttttcctgt tacgataacg 1898701 atcaaaaaca aaataattta tctcatttta agacagaagt tattctgctt tttcaaaaaa 1898761 atattcttga ttttcccttt tttagatgca tccataaagc attcgatcat aaccattata 1898821 tgtaactgaa atgcaggtat aagagttatt atatagggat tacactacca ttatctgggg 1898881 gtgtattaac atccaaatac tcaaaagcaa gaacaaatgt acccatagca cttccatttc 1898941 cacaccctat ccaaattttc attttcctaa ttccacatca aaatcaccct ttttcacatc 1899001 gtaatcacta tcgtaaaagc ctatagtatc aacgtttttc cttcttaaaa ttttcttttt 1899061 ttataaatat cttcccaaaa caaccacttt cccctactcc cgcttatgtt ttacgatcgt 1899121 ttacccccta tttactaatt aaagtatcaa aaattcttat gtttactgtc tttttagctc 1899181 attataaatt tttacgataa gcaattgcct ttgcttttgg atatgacttg actgtatttg 1899241 gtgacgattt aacagagaaa tttaatgctc ttctgacttt tttaactgca ttgggcatta 1899301 ttgttgatcc aacaactcaa ggtatttctg atagtgaaca agcaatggat tatgattcac 1899361 cgagataaac cccataccct tctcttgatt gaggagggta tttttttcgt tttttcaaat 1899421 gaaaaaattg cagaaaactt tacatccttt tacaattttt tcaatgacta tgttatgatt 1899481 gttttcgaga gatttttgaa attttcagaa agaggggttt aaatgagtaa gatcgcttct 1899541 gaagttgtcg ctactacact gaatgactgg tacattgcta taaaaaaaca aaaggttgat 1899601 gaatcaataa aatattattc agagataaag aaactttttg atgaaatgga agaagatcaa 1899661 gaagttcttg cgtattatag tctattagaa gaaagacata aaatgttgct gcattcttca 1899721 cgaggagagc ctttacaaaa gcacacctat tttactgaag acaatcaaaa cttcataaca 1899781 aaaacaaatg ataaattaga atacaacttt tatttatttg aagcaatgta cgaggcatac 1899841 aacaaaaact atgatcgagc aattaaccta tatggattag ctgagaaaaa gcttgcagaa 1899901 attccagatg aaattgaagc agctgaattt tactctaaag tctcttactt atatactctt 1899961 gttaaacaaa gcattgtggc acaacattat ataaaaaatg caatttcaat atataagcga 1900021 caccctgatt ataaatgcaa actagctaca tcaacaatga ttgcagctgc aaactatgct 1900081 gatatgaaac gatttgagga agcagaacaa tattacttag aagcaattga tattgcaaaa 1900141 gaaacaaaag atgaattttt aaaagctcaa ttatttcaca atcttagtat cgtttattct 1900201 gattggaaca aacctgataa atgcattgaa tctcttgaaa aagcaatagg aaatgaatct 1900261 tggttacatt cgatttatta tataaattct ttattcatga tgattaaaga actctttaaa 1900321 attgacgaaa aaatgaaagc cattaatttt tacaataaag cacaggaaag actcatatta 1900381 atggagaata aagtatacga agccaaaatc agcatcctgt ataaccttta ttgtggggaa 1900441 ttaaaaaata atttcaataa ttgtattagt aatattgagt ttttaaaaca gcaaaatgaa 1900501 cttgaaagtg tagatgaatt gtcctacata gctgcaaaaa ggtttgaatc aataggtgct 1900561 tttgaagaag caacgagctt tttcaatgcg aaaatttggg ctgaacagaa aatgaatcag 1900621 gtggagggaa tcttatgaaa aaacttgtgc tttgcgtatc tattttagct gtgattttaa 1900681 gtggagtagc tttaacgcaa ttgagtacag attcaccatc taacatccag gtagctgaaa 1900741 ggccagtcgg aggttaaaaa aggttgatta attaatttag ccctactcaa acatttgagt 1900801 gggcttttat tttatgattt atgtccaccg gtcagccctg ctctgtggag cgcagtacct 1900861 gcaaacgtaa ctgagatact tctcactgtt ttttgcccga gtaaaactta ttaaagaaca 1900921 tcaagcaaca cttataaata tccatcgtga tatttgtggg aaaatcaatt gttttggatc 1900981 gatgaaaacc accgccaagc tcatctttac tgtatccaat tcctagactt attgttcgac 1901041 caactttatt atatgtacgt gcccttcttg cgacttcctc acaaatctcc aagagcacag 1901101 ctttaatctc ttctctcttt gtataatccc taaacaaaat ctgactctta ccaaaactaa 1901161 tctgcccctg catcaatgga gctcctattt cagataaatc aattccgtga gcatgatagt 1901221 acaactggtt tcccattatt ccgaacttct tttcaagcag ctctaaagga aatttagcta 1901281 actgacctac agttgatata cccattcgat tcagatttct ttccatcctc cctcctatcc 1901341 cccacatttt agacaaaggt cgaactttcc agagtctatt tggcacatct tcatatctcc 1901401 aacgtgcaat accactcttt gttttcttac tctccaggtc aagtgcaagc ttactaagca 1901461 acatattgtc accaattcca actgtgcaca tcaaaccaaa ttctctccac atgctgcttt 1901521 ggattgcttt ggccatttct tcaggattct cttttcctgc atctaaaaaa gattaatcaa 1901581 ttgaatacgt gtggacacat ttttcaggaa caaatctgta aaacagcttt gtaatctcag 1901641 ttgaaactct gatgaaaagc ttcatttgtg gatttacaat gtatattctt ggatcttcag 1901701 gtatctcaaa tagtctcgat cctgttttga ttccaaaatc ttttttaagt gcaggagatg 1901761 cagctaacac tacacttccc tgtctatccg tattccctac aacggcaaga taacatgtta 1901821 aaggattaag ccccattgct acagccgata cagaagcata aaaggatttc atatcgacac 1901881 agagtatatt ctcacgtgga aattgtgagt aatcagtcat tgtatataac tcttatgatg 1901941 ttattcatgt tgatataaac tgtattgtcg ttctggtctt ttacgtgaag cttttgttgt 1902001 tcaaaattaa tgtaatgtac tctgccggta acattttcaa caaatccctt gttaaagagt 1902061 ttgaatttca actctttatt aaattccaat gcctcagaaa cgagaatatc catctcatca 1902121 atttgtttgt catctaaaga tggcttttca acttttgatc catcaatcaa atcttgttta 1902181 agctgtatta attgttctag catcattgat gtccattgat agttcctcga tccctaaaca 1902241 tatcgactca ctccttgatt gatctaatat caacagaaca aacgttcctt attcaatata 1902301 gatcagaaca aaagttcgat gtaaatgttg gtaataaaat ataaaggtca ataatgatat 1902361 ccgtagtatt aataaaggag agattctttt cgacgaggga gagtgtgatg gtgaatgaag 1902421 aagaggttaa ttggattttt ggtcttagtt cctgctttga ttatgtgggg tataacttta 1902481 atcgaatcaa acaaaaagac ccctgtagaa gttttagaaa gtgcttggga tgaatttggg 1902541 ttatttagtt ttgaaattgg aataacagat ccggcaatta caataggcat ggatcaaacc 1902601 aaaagtgaag caaaactccg tgaatattta aaagataatc tgtctagaga agccaaggaa 1902661 aaatataaga tttatatatt caaggatgat actgataagc tggagaaaga gcatcaagaa 1902721 tatttgaaag aaaataatct caataagtaa aacgcccagc aattaaaact ggacgttaaa 1902781 aaacattagt tattctttat ttttttttag tattcacacg taatctctct ctatcttctt 1902841 taaaagagga tatgtagttt ttagactcta atgcagtcac caacgcttta ttagttctat 1902901 tatttgagat ctttattcgt ctgccttttt cagcaatttc agagtaaggt tcccctattt 1902961 tagttaaaaa ttcagtaatt gattcattat caatatgctt tatttgtcca gctagcaacg 1903021 ataacctagt atccaatgtt gtaggtgatt caagcaaaaa ggttagtagt tcattggtga 1903081 ttttcaggtt atgctcatta ataaaataaa ttgtatcttt aagaatatca ttatttccat 1903141 ctgtcaaaca gttagaattt aaatgttgta caaatatttc tttgttaaat tgagagagct 1903201 cgttgctatc tatgagttgc tttatatcat tggcatcaag ggaaaaatca ccttgtttat 1903261 caataaactc gtcagggttt ctcaaagcga gttggatatg aagtgtatca aaatttaatt 1903321 ttaactcttt aaaattttcc ggtgttagag ataacaaatc attatcaatc aataattttg 1903381 ctcttttttc actaacattt ccgagcggaa agtaaatcca actttgaata ctagcaatta 1903441 acacttcgaa tgtttcgtct gtaatatccc gactattaat gatttcttct gagatatctt 1903501 ctaaaatcgc ttcgtcaaat ttatcatcaa acgcctctat attattttta gagagctctt 1903561 ttctattaac aggattgttt aagaaagcta ttaagaaatc aggcattttt ttattgtatt 1903621 ctacataaga agtaataacg tttgaccagc atgcaaccat tttattttca cggatcacaa 1903681 ttggccataa ctctttaatc aattcaccaa tatccgagat ggcaaaagtt tttttcatga 1903741 tcattgcatg ctttactctc ttatctaaat cctcccgatt taataactcc agaaaacttt 1903801 cctctggttc ctcaatctcc tcagtaagta aaactttttc aacaaatata tcaatattgt 1903861 catttacgta attgataaca gcctgctgat cagagttttt aactgcagca tacgttatat 1903921 tgggagcatc atttaaaata actgataaag ttttgatatt aatttcgtat agatttcgtt 1903981 gaacaacaaa gtcatatatt gtttcagaat ttagcaaatg atccaaactt ttaaatttaa 1904041 cttggagttt taatagtagt tcttttattt tctcctcatc agatactaag ctgagaagat 1904101 ttaagtactt ggataatgtg aaagacatga ccgactcttt attcattcgg ataatatcag 1904161 ctatatcagc atatgtaagt atatctgaca agtattcctc ttttttctgt tgtgtataat 1904221 tggatctaag ttcaataaaa ctccaaaaat catcccattt actagatatc gattggataa 1904281 aggcagcttt atttattgcc ctttctttaa aaccatctat gaatgtaaca gattctttac 1904341 ttccatttgc aagtcgctca attatgctat cataataatt acggtattca gaatgatcca 1904401 ttatatagtt taagagatga aaattaagta cctctatttg cttaaattca gcaccaacta 1904461 atttgctcat tattttaccg atattatcca gctcaaagct gtaaggcaat gactcgtggt 1904521 ttttaatact aaatacaaat ttaatatcgg aaagacttaa actttctgga tagaagtaag 1904581 tgatgtaatg gttatacatt tcatcaatat atccatgacg tagcaggtaa acaagtaatt 1904641 ttttctcgta aagcttatca gaaaatacat cctttgaatt catttttgta attaatactt 1904701 gtaaagattg cgctcttatt tcttgctttt ctctctctaa ttccaatagt tctttcttga 1904761 atttttggat ttcatttttc tctatagcct tgatggcatc ttctctttca aagtagttcg 1904821 gtttccgacc aaaaacagtt gcaatttctt taattgtcgc tggaccattt ctatttctta 1904881 aataacaata gatagtatcc gcatttttta acttctcaaa aaaccgatct ttattagatg 1904941 tattgcctct aaatacctcg ccatctatat taatatcata attagaattc aaatttgata 1905001 tttctaattc gctcaagtat ataaaattta attcagcaat tgattttaaa gactcaactt 1905061 ctatattcgc taatttcctc tctaattgtt gtattttagc attaattaat tttatttgtt 1905121 cctcaattat aagttgtttt ttttgaaaga tttcatatac caaccctttg ttatattgta 1905181 atttagaaaa atccacagga taaatatttt tgtagattat cattgctaac attttgttag 1905241 gatcaagatc aattgcactt agtttttgtt ggtatataac aaattcatta aaaatattct 1905301 ttaatactct catgtcatca atgtaaattg ttacatcctc taagaaatga gtgtttatca 1905361 aatcagaata tggtgaatgt tttattttct ttttaagtat gtctcctgaa ttagatgcat 1905421 taataattgg tattactggg ataataaaat caaaaaattt tgtgcggtct ctagttaact 1905481 tttcagtgtc tgcatctcca aaaatatcat cttttatcgc atatataaaa acaacacgtc 1905541 tatctatttg ttctgaatta tttataagtt catttaattc tcttaatctt tcaaaaatac 1905601 ctatattatt aaagcgatct aagtcctcaa atattacaac attatacttg gaggcttcaa 1905661 aaaaatataa tatttcatct aaatatttat caaatataga agagttttct tcccctgtat 1905721 ttttttctaa cgttgtatta gcaattgtaa ccttattcaa ttttaagttg gcacggacaa 1905781 aatgataaat tcttttatat gcgagtagag gatatactat aaagaacagt gctaataata 1905841 tagtcagtcg tatttgttgc tgatcttcag taccgagact ccttgaaact aacgtctcag 1905901 catatattcc tttaagtgca tcaggtttaa aaaggtagat gccaactata ataaatgcaa 1905961 aaaagaaaat caaatttata attatgctct tagtccttat atgcttaatt cttttaaacc 1906021 tagaaaaggg aatggttcta tcgtgtaccc ggtatatcat ttgttgcaag atgcttttct 1906081 ctaacttatt ctccatatca tccgtatctg tgttgaatgt agctaaggat atatttaaga 1906141 aactatattc cctgctgtat tgtttttgaa aggtatttaa tatgctactt tttccagacc 1906201 cgtagggacc agttagggcg atatttttca cttttttatt ttctaacccc caacttagtg 1906261 ctttagaata ttttccatca gtgtcgacat cattgctagg agaaagatct tcaaaaaggc 1906321 tttcttcctt aacattaggt tcttttagtc taatcagaag tttctctaac cactgcacaa 1906381 attttttttt gatttccccc aaaaaaaaca aatcctttct aaactttcag gtgtaatacg 1906441 aattaataaa actggagcaa agaactaaat aaatgagtat gtagcaatga caaatcattt 1906501 ctcttccatc taatatagtc ctttatcgcc agttgaaatt cactattaat tgtaacatga 1906561 aagggcatta aaagtttctg aaaaaaagat gatcaataaa caacacagcg cccaattaca 1906621 ggactgtttc atatttaaat tgaattttta taagcattaa ttgcttcatt tcgcagcagc 1906681 atattatctt tgttaaccat gcctaagttg taagcttttt tgataatatc taatacctga 1906741 gaatctaacg ccgaaagatt accgcctgga ttaaatcttg atttccaata atctaaagaa 1906801 ttatttaggt caagtgagct ttttttgttc tcgggtttaa ctacttcatt tttctcaagt 1906861 gtttcacaga attcactaaa accaatggat ctactgggag ctgagttatt tcccccgtat 1906921 ccttctgtag ccaagctgca aaatgctaag aattttggat cataaataag atcgcttcag 1906981 tttacattta ccactgataa tcacaatcct ctcaaagctt tttataattg tagcaccttt 1907041 tccattttta cacatattaa atatcgacaa tcattcaaat gatttaataa ttgaatacaa 1907101 aaaagaacct gcattttgca agttcctttc acgttgtcaa tatattgtga atttttaacg 1907161 acaagggcat ttatgtatag tatgatattt cctgtacagt aagttttgct cactcgaggg 1907221 agtcttgctc atcccctaat gaaaggggtg atgctatgtc aacattccag gcattaatgc 1907281 taatgcttgc aatcgggtcg tttataatcg ccctattgac gtatatagaa aaaatagacc 1907341 tcccttgagc ctcagaacct gaagggatag gcctacctag aaccacatcg agcaagccct 1907401 ttgatgggca actttttgta cagagccggg gtgttggtag cacctcggtc ttttttattt 1907461 tatgcatttc tcattaaaga aatgcactgt aatgtattgt aaaactgatt ataacacatt 1907521 ttccgtgaaa tgcattacaa taaacctcaa gagacttgga aagctttttt attgtttctt 1907581 gtaacgttat aatgatctaa aatagcgcac aagcctttat acatcttcat catttcttac 1907641 tcttctagct cgtctttcaa cattccaatt cccaatcttt ccccagacat tcttgttagt 1907701 ccatttccct agcttagttt tatcaaacca ttcctgaaac aaagatattt catctttcct 1907761 ttgcattgta tcttttaaaa ggaaataatg tattatccaa aagatataaa gagctgaaca 1907821 agaaagtcca aaaataagtt tatttacctc taaccaattt cctaaaactt gttcgcctaa 1907881 atatttatca tatagaaggg gtataaaagc aaatgctgaa gcaccgacaa aaaaagctag 1907941 agtttcttta aaccatctaa caaaaacaaa aacagcgctt aaaatataat tcgttctaaa 1908001 aagaacttta taccaattat aattcttgtt tagagtaaca aatatacttc tatattcttt 1908061 attaactgct tgatctaaca ttctcatttt ataaaataat tttttcctat tctcgctgtt 1908121 cttgtttaaa atatactctc tgaaacaatc ttctgtattc aaaatttgat ctatcaataa 1908181 gatgtttcta agttttgata gcttcccctt tttcccacta tattcttcga aaaatttttc 1908241 tataaggacc attttatggt tttcatcttc ttcattcttt atttctttta gggaataata 1908301 cataggctct aaaatttttt ctaatgtttc acctgattga gagtagaatc gttctatact 1908361 tttttgtctt tgattgaata gcaatgcaac tatacccgta attactgcag taagaatacc 1908421 attttgttgt atccaattcc aaatatctaa taactccaat taagcttctc cccttctctc 1908481 tgaatttact tttaatacgg gctaaaataa aaaaggtttc atataaaacg ggactagaaa 1908541 acttctgtca ctttaattat ttaatccaat aaaataagct ctcattgcga gagcttattt 1908601 tatttagatt gaggatgtgc aactcaagcc ttctattgcg ctatagcaat acttttgctt 1908661 aatcgtccca gtcttcatcc tcatcccagt catctttcgc ttcctgaatc ttattataaa 1908721 aaaattcaat aaagctgtct gcaacagtat cttgataacc aattacccta tcccattcaa 1908781 ctacagggca ttctccgtct ttcattttat ttgtatctag acagtaagca aagtaatcaa 1908841 catcttcaat aaccacaagt ccatcagtaa ggccatagtg ttctttatat tcattagttc 1908901 tatttacaac tgatgcatga tcaaagttgt agcctaaaac caaaacgccg aataaaccac 1908961 cagcaccgta tttttctaaa aaccatttat aactgttggg gagatcgcat tggaggtttt 1909021 cttcaatgcg accaatgttt tcatgacttg caccttctgt aaatatagca ttttgtttat 1909081 tttcattaat aaagttctca accttcgaat aaatcatata aacacctcaa ttctcatttt 1909141 caaattgttt cgctctccat ttccaatatc tctttctaaa gctctcgtat tgtgctttta 1909201 aaaccttatc atttctaaaa ctttcaccat cagacttaag ctgatgaatg acatcactat 1909261 attttgtatg taagctgttc gggatttcaa gcattgggcc aggttcttct tgaatcaagt 1909321 gatgtaaatt aatctgtgta ccgtcttttg cataaggggc attcccgttt ttcattagct 1909381 gaagatttgt aacaccgaat tctgtttttt gattaatatc aatatctttc atagtataca 1909441 ctctacggct tacatcttta actttcccct tcgcctttac cttcccctct atttcatatg 1909501 catcatactt ttctttattt agccaaggag ggcttttctt ttggccagta aacggttttc 1909561 ttgttccatc cggtattttc ttcgcattag tcaaaagttc attcttaagg ttttggctat 1909621 caaccacatt gtatggcacg ttatctgcta gagcaagctt atacttaggg ttgtaaggca 1909681 gcaaatctgg aatcttaacg tccttgattt tcttacctgc ttgacttgct ttatttatta 1909741 ccttgcccgc tgcatctgct ttgttaatgg ctcctgcacc ttttgtacca acaacagcta 1909801 cagccactga accaatagca taggtaaccc atcttgatct agaataggca tctccattca 1909861 ccatatcctt ttgatatgac tcttctattg ctgctgaaat ggcatcgtat gttttcactg 1909921 gatgcatagc tgcattaccc agtgctgaga gtgtttctcc tggatcggtg atgaagtccc 1909981 atatgccggt tacagtgtct tttcctacat cgtataaacc aactcctaca ccttttacga 1910041 tatcccaggt gatttctcct gctccttcta gctgcttcgc ttgttcaatt tgcactgcaa 1910101 gctgcacttg agttggctcc agattctcgt accctacttt cttagcaatc tctaaatatt 1910161 catcagggtc agatacaccg tcattaagtt ttttctttaa ttccttgatt tcacgttcct 1910221 ttgcttcttc tttcttcaca cttaagtaag cttcagaatg cttttcaata tcgccttttt 1910281 tcttatgtat gtcactttct ctgtacgctt tagcgttata gtgaattggt gtagcgtttt 1910341 ttcctttgcc tgttgattcc tgcagctttt taaagtcttg ctgaataaat tgttcgtttg 1910401 gttctgtttc agcgtattct gtttttaaat cctcatcaag cttgtttagc ttatcgattg 1910461 ttttttcacg tttgtcatct gcagaagaaa gtttgtcttt gaagtcttct gttgagaata 1910521 tttcaagggg aaggatatca ttgatgttgt ttaatatgtc tttcattgct tttttctgtt 1910581 cagacataat ggattttgat tttgcataag cgttagccaa ctcgtgttct agaaaggatt 1910641 cttctatgta agcatcagac atcttcgcat cttcaagtgt tgcagacatg ctgcttaaga 1910701 aagcaatctt catatcgata agatcaatcc attggtctgt tacgccgaca tgaccatgat 1910761 aaaatgcttt aatgttgtca gcacccttgc ctgaaaattc actgtcatct aggttagcta 1910821 cttccttaaa cgcttttttg agcttcacca tttgcgacct tagttcctta tactctttgg 1910881 ttcttttatc cgcttcaaag agtaatgaat cagcctcaaa taccttcata tcattctcct 1910941 tcctagacta cttctatgta aattttacca cagtaatcta attgaataac agaaaaagac 1911001 agccaaaatg actgtcttat acatcacaca ctatcttgtt ctataataat tttctgcggt 1911061 atagtagcgc caatcccaaa aaggttcccc attggccaat atataccggt ctaaaaattt 1911121 ttcaaagttt aaatttaatg gattatattc taaaccactt tcaaatatat agagatagtt 1911181 gggatcacct tggttcactt tatctttatc gatcattaaa tggcattctt ccaataagta 1911241 gccaattgga ataccattga tatcttcaaa caaatcttca tattttaact cctcttcaat 1911301 ctcttcaagg ctaaatagct gaagtcctcc acctatattc tccccatcag aaagaatctc 1911361 aaaaattttc gcaccgttat gtagtgtcat gaacttctga taatcctgtg gaagggtaag 1911421 ctggtgttta gcctcaaagc tttgaatgtc attcagggtt gctttgtcct gtgaaaaagt 1911481 aacaaggaac tccatgatat caccttctga acaaaacaat tgaatggctc ctttttcgtc 1911541 taaaagactt ttcaagccat ttacagtctt atgaacaaag ttagtcacat acatcacccc 1911601 tttatttcct tttaacaata acctttcaaa ttccaaaaga tgtgaacaga tcgtgatagg 1911661 tgctcttttc agtgaatata atgcaataaa ttctaaaaag aggtgcctcc aaaaattgaa 1911721 ttctctaatg aatgatgaca tggtaaagat cattagaaat ggccttagcg catcgcagca 1911781 tccaaagcac attcttgtta taggagctgg attgtccggg cttgtatcag catctttgtt 1911841 gaaaaatgcc ggtcacagag taacgattct cgaagcgagc ggcagagcgg gcggccgtgt 1911901 ctgcactttg agatctccct ttagtgatga tttgtatttc aacgctggcc cgatgcgcat 1911961 accgaataac cattcgttaa ccttagaata tatcaaaaaa ttcaaattgc caacaaatgt 1912021 atttatcaac agaaccccga tggacatcat ttatgcaaat ggaatcaaaa cacgtctcca 1912081 agtttttgaa cgagctcctg gaatattgag atatccagtt gcaccaaatg aacaagggaa 1912141 aacgtctgaa gagctgatgc tttctttact gcagcctatt ctaaatttta tcaatcaaaa 1912201 tccagcaaga aattggcgga ttgtcgaaga acaatacaaa aatcattcgt taagctcttt 1912261 tttaaacacg tatttttcat atggcgcgat cgatatgatc ggtgtacttt tggatatgga 1912321 agcgtatatg gggatgtccc ttgttgaagt attgcgggaa tctatctttt tttcatcccc 1912381 cgctcacttc tatgagataa ctggcggtat ggatctgctg cctcacgcgt ttcttcctca 1912441 attaaaaaca aacattctat accatcaaaa aatgatgaaa atgtctcagg gtgaaaatcg 1912501 tgttacgatc cattgtcagc atcaacaaac ggcagaattc acatcattca cagctgatct 1912561 cgctattgta accattcctt tttcaacatt gcgatttgta aaagtcgaac cataccattc 1912621 attctcttac tataaacgga gggccatccg tgagctaaac tatatcagtg caacaaaaat 1912681 cggcatagag tttaaaagcc gattttggga aaaagccggt cagcacggcg gcaaatctat 1912741 tactgatctt ccgattcgtt tttcatatta tccaagcaga aatattggag caaatggaca 1912801 tgctgtcatt ctggccagct atacatgggc cgatgaggca ctgatatggg acagtctttc 1912861 agaaggagag cgaatccagt atactttact gaatttatct gaaatctatg gtgatattgt 1912921 gtggtctgaa tttgtgtctg gcacttcttt tagctggagc cagtacccgt attctgcggg 1912981 aggttttaca gctttcgaac caggacaaga attagagctg tatccctata ttcctgtccc 1913041 tgagggcaga gttcatttcg ccggagaaca cgcctcactc actcatgcgt ggatgcaagg 1913101 cgcgattgaa tctggaatac gtgttgctta tgaggtcaat cgcttacctt agatcatgct 1913161 cacatcttgt taaaactggt tgatataaaa agaagtgaag aatttatact cctttgttta 1913221 aaagattaat tcaaatatgg gatgtctcaa cattcggttc tttattatct ttatacacgt 1913281 tttgaatgcg gacctccctt ttcttccata atcattaata aatacccaac cataggaaac 1913341 gttttaatta accatcgggc gaactttctt tcactgtata acgattctta atgttgcttt 1913401 ttatccttta cttgtcctct ctttttttca ttgacttaca tttcttgaaa accagtataa 1913461 atcctaaagg aattttgtaa caaatacaga attggaaaga gaagcgccaa aagaaatgct 1913521 aactccttat ctcaaagaca aaactgcgct tatattaaaa gaaagaggtg tctttagaat 1913581 ggttcatttt aaaaactgcc ctgatccttc tctaaacgcc aattctcagt ctcaccccga 1913641 attttcatcc gaattagaac atattaagac aagaatgcaa aactttatta agcactcggt 1913701 tacagaccaa aatatcgaag ttactgacgc aagggtgacg gccgaaggag aggtcacctc 1913761 tcttttaaaa gaacgtctcg acaaggaata ttataggctt ttatctaaaa tcacccggga 1913821 agtaaatgtg gctgacttcg gcgctgttcc agatggaaga gacaatactg aagcttttcg 1913881 aaaagcaatc gggaatggcc gagtcaaagt acatgttcca gcgggagaat acctcgttca 1913941 agggattaaa cttccatctt ggacaacaat tgttggacaa ggtaaaggga tcacagtgat 1914001 taaattgcat gaagacactc cagcgcatga atgggtgatt acaaatgatg attatcaaaa 1914061 tggaaatcgc aatatttttg tccaaggaat gtcattagac tggaatccaa gtagacaatg 1914121 cggtgtgaga aatccagggg gacagttctc cagttgttta acttttgcta aggttgaata 1914181 tgggtggatc aaagatgtgg aagcgattaa cgcaggtctt catggtattg atattacatc 1914241 gccaacgtat gaccatttgc ctgataccga ttggacaaaa gacggatcaa gatatatttg 1914301 gatcgataac tgtgtgacat atggttcagg agacgacggc attaccaccc attatagcga 1914361 atacatcttt atttcaaact gccattcagg aaatccgcgg ggaacagaat ttgctgaagg 1914421 tgtttcaaac tccaacggaa tagaaattga cgacggctct aggcatgtgt ggcttttgaa 1914481 taactttaca agcggcaaca tccgcggagt tgaagtaaaa gcccatgaac tgtggccagc 1914541 ctctcaaaac gtccatatca taggccatat ttcttatcgc gatgttcgtg catttgatct 1914601 tcgtcatatt ggtcaccatc aaattacaga tcctgaaagc acaacagcat acgatgtcac 1914661 actcattgat tgttcagcag ttgaaccagt tttcaactcg ctttacgatg ctgtgacccc 1914721 aagagcgctg gttatttcgg catataaaaa cgttaatgta agcggattca cagcgattgg 1914781 tgatccagac tatgattata aagaaaaccc tgtcgtagcc ttgcaatatc gcagccaaaa 1914841 tataaccatt aatggtatta aaattcgcgg ttttaaaaaa gccggtgttg atattaattt 1914901 atcaggcgga tcaaataaaa ctgattatat taaaatttca aattttgata tttataaatc 1914961 tgctccaaaa ggaatttcaa tcggtggagg cctctacaat gtcaatattc taaatggaac 1915021 gatgattact gacaatggga cagttgcaat tcagtccccc aataatcagg ccacaattct 1915081 cggtgtacaa tcagaaggtt atagtgtggc agcctcaatc aaaggccaaa cataccaaca 1915141 agttccaatc aatttgaaag gaggcataca gcttgcaacg acctctggct ttgccgttaa 1915201 ccaaacaagc gcagttatag caggtaccgg cgacattacg gcccgcggag aaagaaatgc 1915261 ggtcattagc tcttctggag gctccagtac tgaaggctct cgcgcattaa tcgcttcttc 1915321 aaataacgca catattagag gaaaccaagc gtcaagaaca atactgtctt ctgaaaatat 1915381 tatacttgag gaaccataca ccgtggcagg aggtcatcaa tcaataaagt ggcttcttga 1915441 ctctgttcgg ggaaacggga cgtttgccgg tgcaatcagt tcttctttag gtggatatgg 1915501 agagtatttt gagagttcaa ctggacagtt aatccatact ggtacaatcg tgactttaag 1915561 aggtgaaaaa attgtgcccg cgaatgttgg agattatatg cttggcgtta tttcagaaac 1915621 ttcagctttc atttcaggag cctccagttt cgtctggcag ggccgttatt tgacaaatga 1915681 gttcggcgga tttatttatg aaacggtgac tgatgaggaa agcggtgaac tcatacgtgt 1915741 tcccaaacaa aatccagact acgatacagc gctggaggca aattatcatt cacgggcagc 1915801 aagagacgaa tggcacgttg tagggttggt tggccaacat tatgtgcgta ttgacgaaac 1915861 tgtcaatcaa ggagattatc ttacggcaca taatggaata ggaacaaaag ccactgaagg 1915921 aagctggaaa gtaatgaaaa taacctctgc ttacacatca gaaaaagggt atggtatcgc 1915981 tctaaccgtc atcaaatagt ggatacgccg accagttcaa tatatgttta tccaaataat 1916041 tagatctctt ttctaggttc tttattcctt gtatgttatt atcaattttc aatatctacc 1916101 aaaatacccc taatatacta tcgtaattaa cttatattat aatcaaaaaa attttgacag 1916161 ctgttccttc tcgttattca tgaaagttgc tattgaaatg agtaaatgga tatcatatta 1916221 gacttctata gcaaatacac catatatatc ctttaagtat ttacaaattg aaaatgtttc 1916281 atgaggctta ttaaaagtat tgttctttta tcatctgtaa gtcgatacaa actgcattaa 1916341 gatcacacct aaatctcact gagttttttc ttacaaataa aatgaaaacc ctttccattc 1916401 taaattcatt tcaccgttac taaaagtaat ccttgcattc cttcgccctc catgctatat 1916461 tcatatagcg atgagctgaa ttgtgtaagc cgatgtacat gcctttacgg cacacacgaa 1916521 tgtggcgtgt ggtgcatcgc ctcaatacgc aaagacgttt gccttaggca aacgtctttt 1916581 tttgcgttat ccgatttttg tgccgtttgg gacaggctga tccggctgca aaaggacgac 1916641 gtcgccctgg ccgggtatgc cgccgaggac caagacttcc gatttaaatc cggcgatccg 1916701 gcggggcgga aagttcacga ctgctatgac ttgcttgttg atgagacctt ccggcttgta 1916761 acgcttcgtg atttgtgcgc tcgattgttt tatgccgatt tcagtcccaa aatctatcac 1916821 aagcttgatt gccggtactc ttgcttcagg aaattcttcc gcttttacaa ttgttcccgt 1916881 tctgatatcc aatttctcaa agtcatcaat aactgccata tcaataactc ctttttctcc 1916941 tattgtaaag gagatataca atattctttt aactaaagag ccatcatttt ttatccgaat 1917001 ataaggtgtt tcgatacagg cggggcggca ttcctgtgct tttcgtgaac catcttgtaa 1917061 aagaagaaag gttttgaaag cccagcgcct cgctcacgac ggtaagagtt tcatttctct 1917121 ccatcagcat tctttttgct tcctcaaggc gaaggtcggc aatatagttc tgcggggact 1917181 tccctgtctg ttttttgaac cagcttgaat agtaagctgg gtgataatgc tcgatttctg 1917241 ccagcttctt aatcgtcagc cgctcaaata aatggctgtg aatgtatgca attgaggcat 1917301 agctatggga ttgaagcttt tcttttatgt attgtactag catatgaagc gagttggctg 1917361 ttccggcctt tgcttcctct gtcagcaagt acctgatcga agaccagaaa ggatcgaggg 1917421 cagcttcaat tcctgatcct gcacgatact catcaatttt cattgcatga agcggaacat 1917481 ccagtacaag acattcattt cttccgatag aacggaagcg atgctcgcac tgcggcggaa 1917541 tatataaaaa atgatccgga tttaatttca cctggcgccc ctcagtctca agatcaatac 1917601 tcccttcaag cggaaaaaga aattggctgt acgcgtgctt atgtgaatga tatagccgtg 1917661 tgtatgtccg tttttcgcaa attatctctt gaagcgagtc cattagcaaa ccccttcctt 1917721 tggtcatctt ttaatccggt aatggtgttc cgatataggc gaaaagccga tttttccata 1917781 taaagaaact gccgccagat tttctttcat cacttgtaaa aacatgcgtt ccgctccgtt 1917841 gttttttgcc cattcagtca acaccctgat cacttgggtt cctgcccctt ttcctctgtg 1917901 ctcctcagct acaacgatat tactaagtcc gccataacca tcaatgacag aaaccgtgcc 1917961 aagcgctgtc aggctttctt tgtcatacat cttgaaaaaa gttttacacg gcggcatgcg 1918021 ttcgaatatg tgtttgtaac ctttgtgacg ctcgggtgaa aacccttcta attgaataaa 1918081 ttcatctatc caaacagatg atggctcttg ttcccacttg tatgtaaatc ggctgttgtc 1918141 atttgttcgg ctcataattg accggcacaa cgctgtcatc tggaagcact cgtctacctt 1918201 ttcataacgg ctgtctgcca atgcgtcatc aagccctttc ggtgatgcgt tgctaatatg 1918261 aaaacaaaca ggtaagccta aactttgata aaaaagttcg gcctctagct gaaaatcccc 1918321 ttcaggcata tccgcagacg tccatacgct atttgccctt ttggttacgc caaaattcgc 1918381 tctgagaagc catttcccta tgcttttttg aaaataagcc ggccatgaag ctgccgctaa 1918441 tcgttcaatc ttgcgaatgt catccattgc ataatgcctc tcccctatgt atactccctt 1918501 gatattatac aatattcaga aatataagac atccatttat ttgtttacat aatattttta 1918561 ttgtttatta ataatcctga caaaaatgtc cgaattgaaa atgacaggct ttctaaaatg 1918621 tcctcctcac gttcaaatgc ttcttttgcg attaaaacag taaagccatg cagcagactt 1918681 ctgagccccc ttgtcgcatg aatggcagtc ttttcacttg catagccgtt ttcaatgagc 1918741 agcttcgtca caagacagac aatttggtca gagacgattt ccgtccgttt gtcgtgaacc 1918801 ttaagaagag ccgcttcata atatccggga ttttcaattg caaaatcaac atatgcatga 1918861 gctaaagaaa gcatcgcgga atctcccttt cgttcggtta cggagtccgc catttgatca 1918921 aaaagctttg tcagtcctct gacagcaagt tctgctctga tcgcttgcag cccgttgata 1918981 tggttataca atgacggggg gcgaacattc atttttttag aaagtgcagc aagtgagaca 1919041 ccatttaccc cttcctgatc ggcaatctct gctgcagcgt ctacaatcat tttttgggtc 1919101 aaacctattc tcggtgacat gctcatcatc ctttctttgc tttttggatc gcctgtctca 1919161 tccgctctga aggtgatcgc aggaattttc catgtccgac agcgagacag gaaggcgcct 1919221 tatcggcgag caattgtgca cttttgatgg cctcctcctt attccatgtg gcgaaagcgg 1919281 gaaaaggaaa cgcccatttt atctgacctg atacagcgat tcctccgcgc aactgaaacg 1919341 catctcctgc tattaaagtg ccgtttcttg tatcaagaaa tgacatgctg cccggtgtat 1919401 ggcccggtgt tggaatggca agcagagaac caattgtttc accgcccgtc agcagttggt 1919461 gaggctttgt ttgtatgtgt ttcggaatac ctccttttat aggcgtctgc ggctcatctt 1919521 gccgcaaaga tgtgtcacct tggagcaaga atgaatcccg ttccgagatc atgacctttg 1919581 catgcggaaa tgtttgtgcc aatgtatcca gtgatccgac atggtcccca tgtgcatgag 1919641 tcagtaaaat atgctgaagc ggttttccaa gctgattcac agcttgaata atccctttat 1919701 agctgcctgg cagtgcggca tcaataaggg tgacttcgtt ttcttcctct actaaatagc 1919761 aattaaccgg aaacaatgct ggaaaaaaag tcagctgcca aaccgtttgg tactgagtaa 1919821 ttctcatctt tttattcctc ctaacaaaaa ctaatggtgt tagttttatt attaactaac 1919881 accattagtt tttcaagagt ttattatttt tttatcgcta cataaatgtt aacttgtgct 1919941 cgctgtggca ctgcggcatt ttgatcatac atctcaaagt cacctgtaaa cgtgcgcaga 1920001 tgccgcttat cccaagtcca aatttccttc cacgtttcaa gcacaatctc ttcaatagga 1920061 ccgattctgg aagtgaaaac ggcgtaagcg gaagccggca aatcaatatt ttcatatggt 1920121 cccggaagaa tgtcgtcgta ttcctgaaac gttccgactg aaaacgtata aaacccattc 1920181 gtctcttgtt cataattcga atataaggca ataatgctct tgtctttttc agcctgtgat 1920241 aaaagagcgc tcatatcctg cttccataat tgatcccaca gtgccggaat cctcctttct 1920301 tccgtcattt ccagtgcgtt gcttgtccgt tgtgatagtc cggcaaatcg tttcaggtct 1920361 aagtgtgtta tatgtgaaaa gcccatacga tctcctcctt tttttaagat tatagacaaa 1920421 gaaacctgac agcagtgtgt caggtttcat atattttttg catgtgatga atggtttctt 1920481 ttactttatc ccttatatga agaggctgca gaacctcaat atcctttccg aactggagca 1920541 aaaaaccgat cagccattga tcttctggaa gtgaaatcac cgcctggcag atttcatctt 1920601 cctcacaaca gtgaaggaca tcatatccga accattcacc tatacgctga cgtgctgacg 1920661 gctgaacaag aataaccaat tcagttaaac ggtccttttg gtaccaactc ttatcccatg 1920721 gcaaagtgtc cagctgaatg tcttttctga taaatgtctg atgtaagatg gccagatctt 1920781 tcatccggtt cagtttaaaa aagcgaaaat catttcttac caggcagtag gcatataaat 1920841 accagtgccc cgccttgcaa accaatgtat aaggttcagt ttcccgaagt agtgtttccc 1920901 cgcttgcgct tgtatatgta aaagatatcg ttaacaaccg atcgatggca gcgctgattt 1920961 tctcgcgcag cgtcttttga tcctcagtat ggccccaagc cgtcatgtca ataaaccatt 1921021 tttctgtttg gtgcttaaat gcttgagtag attgctcagg tataaggtgt ttgatttttt 1921081 gataggctgt gctgtgagaa acgggttcat acatagatga aacgctttgc aaagcggaag 1921141 caattgcaaa caattcctcc tccttcagcc actctctttc aagccgatac gtttccatga 1921201 tgccaattcc gcccccggaa ccctgtgagg tcacaatcgg aataccagcc ctattgatcg 1921261 tctcaatatc acggtaaatt gttctgacag atacttcaaa cagctcagca agctctgcag 1921321 cctgcacttg ttttttgctg atcaataaca caaccatcgc taacaaacgt tccagtttca 1921381 ttctgcgcac cttttcttct tgtattttcc aacaaaacaa tcataacatt ttgataaagc 1921441 ttgggcatat ctattatgcg gcggaataca cctcgcatat gctatgaaaa caggggtttc 1921501 cccttctttt ttgtgttcag tatttatttc agctactatt tccgaccgga taagcataca 1921561 cttctcaacg gaggggattt cacatcatgc atcttacact tcagagcgtt tatcctgcca 1921621 taatcatcat cttttttctg tataaaaaaa ttaaaaggtc catcggatac cagccgctga 1921681 agccccgctg gctgttcacc cgtatcattc ttttctcgct gtttgctttt ggactttcaa 1921741 tcttcagcgc cattcaccct tttttatatg gatatctcat tttgggcatt cttggcggat 1921801 ggctccttgt ctttttcgct aagaaaaaca tctcttttga aaaacgcaga ggaaagatct 1921861 attttcggac tcatatttgg gtagaggtga ttctcttaac tttatttcta tcaagatttc 1921921 tgtatcgagt gacggagctt tatcttacct cacctgatct aaaccgcctt ggatcataca 1921981 gtcagtcaat cggaacggac cctctgacaa ttggcgtctg ttttctgata gccgtttatt 1922041 atatcggttt ttcttctttt atcatcaagc tcagcagaaa cgaacttgaa cagcacgaat 1922101 acaataaaga aaaagacatc cttgcccgct aacagcgagt taagcaagga tgtctttttc 1922161 aatcatgctg tgtatgatgg atcatttgct gaagaacatc taaaacatgt tcatcctccg 1922221 gagagtaata aatcgatgtt ccttctctgc gcgatttgac aagccggaga ttttttaaaa 1922281 atctaagctg gtgggacaca gtggattgca gtaaattcag cttttctgca attccgttta 1922341 ctgcatgctc accttgggac aataaatgga gaattctgat tcgggtagga tctgaaagcg 1922401 ctttgaatgt ttgcgcgact agaaacagcg tctcctcgtc cagatcagca gccgattgtt 1922461 ccgtttctct aaattcagtc atatgtatca cctttcttta ttcatagttt tatcttataa 1922521 caaatgcgct tgagtgcaaa ccagcctgct tgtattccat ttcaatctca tagtttaaat 1922581 ttatgtttca aatcaggttt ttacttggtc tgatataccc tcttatgtca taataaaaaa 1922641 ggtcatactg ctccaaacat tgagggtgaa acacagtgaa gaaaaagaga aaaggctgtt 1922701 tcgctgctgc gggttttatg atgatttttg tctttgtcat cgcctctttt ttattggtcc 1922761 tgcttttttt caaccgggat ttaatcaaaa aacttccgat cgatacgaaa acgattgttt 1922821 tggaacgttt aaccgattac aaacccttgg tggaagaaga gcttgaaagc caaggactct 1922881 ctaattatac atcactcata ttaggcatga tgtatcagga gtcaaaagga aaaggcaatg 1922941 atcccatgca gtcctctgaa tctctggggt taaaacgcaa tgagataaca gaccctcaac 1923001 tcagtgttaa acaaggcatc aagcaattta ccctcatgta caagaccggt aaggaaaaag 1923061 gcgtggattt ggataccatt attcaaagct acaacatggg ggcaggttac attgattttg 1923121 tagctgaaca tggaggaacg catactgagg aattggcaaa acaatactcc gagcagcaag 1923181 tcaaaaaaaa tcctgatctg tatacttgcg ggggaaatgc gaaaaatttc cgctatccgt 1923241 attgctacgg tgattatacg tatgcagaaa aagtaaaaga aaaaacaaaa actgttgaag 1923301 aatctttgca ggttgcaaca cttgaaacca tggaatccaa ggctcatgaa taagagtcta 1923361 tcaatttact gacaaaagcc caaaaatgaa tttgggcttt tgccatgttt acacgtaaaa 1923421 aaagccatac tgagtatggc ttttaataat acggtgaaat catcaaatat acaataacgc 1923481 ctgtaaggct tacatacagc catagaggca ttgtccatct cgcaattttt ttatggcgct 1923541 ccacctgcat gctgaagcct ctgatcagcg taaacagcgc aagcggcaca ataattgcag 1923601 aaaggcagat atgtgtaatt aaaataaaga aataaatcgg gcgcataata ccttctccgc 1923661 catagagcgt gttttccgca atcgagtggt acgtcacata gcaaatcaaa aatagtaatg 1923721 ttgttgtgaa cgcagccaaa ataaagcgtt tgtgagcttt gatatttttc tgtttaatca 1923781 taatcagcgc ggccaataag aagataaacg taaagctatt gaatatcgca ttcagcattg 1923841 gcaaaatgtg aatattcgca tggctgaact gatctaattt aggcataaaa aacagcactg 1923901 cgattaaacc gttaatcaga actgtcagcg taaggacaat ccccgtgtaa tttttcggtt 1923961 tattttctgt ttggttcatt tggtgacctc tcctaatttg tactggctat ccaaatcgta 1924021 tgcaaattca aagaagatgt caacggtttc gattgcttcg tcagaaatta gacacacttc 1924081 aaaggccgga ggctattagc cccggcctgt taggtttacg cctcttttat caaatgttca 1924141 atgaccttat gttcattttc attcagcagg ttcttttgaa ttttcgaatg aatgggttta 1924201 ttcatatgct gatccaagat atcggccgtt tctttatccc cggcaataac cattcgttcc 1924261 catcttttcg cggcagcttt ttgatcaagg ctggcagcca gccgcttata cagtctcgat 1924321 tggttctctg ttacatgttc cctcatccgg ttctcttcaa atggtggcgc tttgtctaca 1924381 gcggaatggc tattcttcca agactcattg atcatatcat actcataacg ctccaccgcc 1924441 tcaatttttc ctaaaacagt ttcaataatt ttcacttcat gctgctgagt taaaataaac 1924501 gccgtacttg ggtatgtctg gcgcaaaccc tttagctgat ccaggacagc tgtttcttcc 1924561 cagtaaaatc ttgtatctac agggacttga agcttaatag gttcccatat gccgctgtcg 1924621 gaaacaaaaa acacgagact gcggggcatg tcttttccca ttgcattcaa gtattgattc 1924681 attttagccc tgattccatc cagacacttt tcctcctctg gatcactagc tgccaaatac 1924741 tcttttaatc ggctgaatcc tgactttagg gcaatcttcc attctccccc ctgctgctct 1924801 ggatctctca tgtctgtatt gagatacaga gagagaattt tatccggcgg ttccaattgg 1924861 acatactgta atttgttaat caatgaatca atcgccattc cgattcctcc tttttcacag 1924921 gttagttttc tttttcctct cttaaaaacg atcaaacctg actttccgct aatttctagt 1924981 aataatggaa ttgttgttta caatacgcct ctcttctaat acaattggta actgtgtttc 1925041 taagctgttt tttgaaagga gtttgatctt gtttactgtt aaagaaaaaa atcgtcaaga 1925101 gcttgaggaa gaactaaatg atttagaatt tcaaatttat cgcatgcagg agaatatgaa 1925161 ggatttatct aaagatgcca aagtgcttgg tattgatcaa tcgaaacatg atgagtggat 1925221 gattgtttcc tcgattgatg atggccaaac atgcaaaatt atgctaactg attgtaaaac 1925281 ggcataccga ggaaaaggct gtttttcact tgtagcgtct tacaaggacg atgccattca 1925341 tataggggat ataaaaggcc ctccgaatca cgggtttggc tccatttgca tgaaatattt 1925401 aaaagatatt gcaagagacc ataatatacc gaaagtcacc ggagacatcg ccaaacggga 1925461 ttggaatcat gtagaccggc tgattcactt ttatgaaaaa catcacttca aagtatgtat 1925521 cgatcatgat acccaatccg gcagcattaa gtgggttgat ttgtaaaaaa gtctggaaga 1925581 aagagccaag atatgctgta atggtataaa accattgatg gagggttcta tgtacgcctc 1925641 aaaactgaaa aagggagacg aaatccggat cgtgtctccc gcgaccagca tgtctatatt 1925701 atcaaatgaa gcaaaaatcc aagcaaaaac ggcgttagaa cgcttaggtt atcgggtaac 1925761 catcgctgaa cacgcaaatg aatgtaacga atttgattca tcctctatcg agtcaagagt 1925821 ccatgatctg cacgctgcct tttttgatcc aggcgtcaaa gcgattttaa cgacactcgg 1925881 agggtttaat tcaaatcagc tgctgcgtta tcttgattac gagaaaatca aacgacatcc 1925941 aaaaattctg tgcggttatt ccgatataac cgctctttgc aacgctattt atcaaaaaac 1926001 gggtcttgtt acgtattcag gtccccactt ctcaacattt gcaatgaaaa aaggactcga 1926061 ttatacagag gagtattttc tttcttgctg cgcttcagac gatccgtttg aaattcaccc 1926121 ctcaagtgag tggagcgatg atcgctggtt tttggatcaa gaaaacaggc gtttttatcc 1926181 taataacggc cctgttgtaa tccaagaagg ttatgcggaa ggtactttaa ttggcggaaa 1926241 cttatgcacg cttaatttgc tgcagggaac ggagtatttt cccgaaacag aacatactat 1926301 tttattgatt gaagatgatt atatgtcaga catccatatg tttgaccgcg atctgcaatc 1926361 actcatccac ctccccgctt tttcacatgt aaaggcgatt ttgatcggca gatttcagaa 1926421 agcatcaaac gtatcaatag atcttgtaaa agccatgatc gaaacaaaaa aagaattatc 1926481 cggcatcccg atcatcgcaa atataaatgc cggacatacc tcgccaattg ccacgttccc 1926541 tataggagga acatgcagga ttgaagctat ttcgggtaca tcacgaatat ggattgataa 1926601 acattaatca gcttgtaaat ttttttacaa gcttttttag cgcaatcggc tatgcatgcc 1926661 gcacgagaca tgacaaatgt catataggag gcatgatgtg tgctactaca aaagacttct 1926721 ctcattagcg tatactgaac cgagacacac aatgagagga tacttactat gactgaacaa 1926781 accattgcac ataaacaaaa acagctgaca aagcaagtcg ctgcatttgc tcagcctgaa 1926841 acaaaaaaca gcctgattca gcttttaaac acgtttatcc cattcttcgg cctatggttt 1926901 cttgcttatc tcagcctcga tgtctcctat cttcttacgt tagcattaac ggtgattgcc 1926961 gcaggttttc tgacaagaat ttttatcatc ttccatgact gctgccatca atcttttttc 1927021 aaacaaaaac gctataacca cattctcggt tttctgacag gtgtcctgac tttattcccg 1927081 tatcttcaat ggcagcacag ccattcgatt catcatgcaa ctagcagcaa tctggataaa 1927141 cgcggaacag gagacatctg gatgttaaca gtaaacgaat ataaagctgc atccagacga 1927201 acaaagcttg catacagact ttatagaaac ccgtttatca tgtttattct cggaccgatt 1927261 tatgtttttc tgatcacgaa ccgttttaac aaaaaaggcg caagacgcaa ggaacgtgta 1927321 aacacatacc ttacgaatct ggcaattgtc gcgttggctg ccgcttgctg tctgatcttt 1927381 ggctggcaat cgtttttact ggtgcaaggc ccgatatttc tgatttcagg ttcaatcggt 1927441 gtttggctgt tttatgtgca gcataccttt gaagattctt attttgaagc ggatgaaaac 1927501 tggagctacg ttcaggctgc tgttgaaggc agctcatttt ataaactccc gaaactgctt 1927561 caatggctaa caggcaatat tggttaccac cacgttcatc atttgagtcc aaaggtgcct 1927621 aactataagc ttgaagttgc tcatgaacat cacgaaccat taaaaaacgt accgacaatc 1927681 accttaaaaa caagcctgca atcacttgcg ttccgtctat gggatgaaga taacaaacag 1927741 tttgtgtcat ttcgggctat aaaacatata cctgtaagcc ttccgcctga ttcaccagaa 1927801 aaacagaagc tgcggaagaa tgcctgatga taaaggaggt cttctaatat actagaaggc 1927861 ttccttttta ttgttggagg gtgcattctg gctttcacaa tgataaagtt acaagtaaga 1927921 tgaaaagctg aaaatgaggt aagatcatga ttaaaaatca ttttacattt caaaaactaa 1927981 acgggattac gccctatata tggacgatat ttttcatcct ccccttctac tttatatgga 1928041 aatcatcatc tacatttgtt attattgtcg gcatcatttt gacgctttta tttttttcgg 1928101 tatatcgatt tgcttttgtc tcaaaaggct ggaccattta tttgtgggga tttttattaa 1928161 ttggcatttc aaccgcctcc attactctgt tcagttatat ttattttgct ttctttattg 1928221 cttattttat tggaaacatt aaggaacgcg tcccttttca tattttatat tatgtccatt 1928281 taataagcgc ggccgtcgca gccaatttca gtctcgtatt aaaaaaggaa ttctttctga 1928341 cacaaattcc ttttgtcgtt attaccctca tcagcgcaat tttattgccc ttcagtataa 1928401 aaagccgcaa ggagcgcgaa cgacttgaag aaaagctcga ggatgcaaat gaacggattg 1928461 cagaactggt aaaattagaa gaacgtcagc gaattgcccg cgatctccat gatacgcttg 1928521 ggcaaaagct ttctcttatt ggtttaaaaa gcgacttagc aagaaaattg atatacaaag 1928581 atcccgaaca agcagctcgt gaactgaaaa gtgttcagca aacagcgcga acttctttaa 1928641 atgaagtaag aaaaatcgtt tcctctatga agggcatccg gctcaaggat gaattgatca 1928701 acatcaaaca aattctcgaa gcagctgaca ttatgtttat ctatgaagaa gagaaatggc 1928761 ccgagaatat ctcattgctg aatgaaaaca ttttgagcat gtgcttaaag gaagctgtca 1928821 caaatgtcgt caaacacagc caggctaaaa cttgccgagt tgacattcag cagctctgga 1928881 aggaagttgt gattacagtg tctgacgatg gaacattcaa aggagaagaa aattcctttt 1928941 caaaaggaca tggcttactc gggatgagag aacggcttga gtttgcaaac ggaagccttc 1929001 acatcgatac cgaaaacggg accaagctta ccatggcaat tcctaataat tcaaaataaa 1929061 cataaaggat ggcttatatg attagtatat ttattgcaga agatcagcaa atgctgctgg 1929121 gcgctttagg atcacttcta aacctcgaag acgatatgga agtcgtaggc aaaggtacaa 1929181 ccggccaaga tgctgttgat tttgtcaaaa aacgccagcc tgatgtatgt attatggaca 1929241 ttgaaatgcc cggaaaaaca gggcttgaag ctgctgagga gctaaaagat acaggctgca 1929301 aaattatcat cttaaccacc ttcgccagac ccggttactt tcagagagct attaaagctg 1929361 gcgttaaagg ctatttgtta aaagacagtc cgagtgaaga gctggccaac gccatccgta 1929421 gcgtcatgaa cggaaaacgc atctatgcac ctgaactgat ggaggactta tacagcgaag 1929481 ctaaccctct tacagataga gaaaaagaag tgctcgaact tgtggctgac ggtaaaaaca 1929541 caaaagaaat cgctcaggaa ctcagcatca aaagcgggac ggtgcggaat tatatctcaa 1929601 tgattctaga aaagcttgaa gtgaaaaatc gaattgaagc cattacccgg tcaaaagaaa 1929661 aaggctggtt taaataaaaa aggatcttgg catctgccag gatccttttt gttaacctga 1929721 aattcccgtt tgagaacctc gtcgcaacca gaattaaatt gatccatatc ctcgctccta 1929781 cgcccgctga acgattgttt ggttaacagc ccaataaaag actggattga atgatatccc 1929841 tgttaaaatg gtcggccatt gcacatcagc agaatttctg atattgatta tattgtattt 1929901 tcagtatgac aaagttgtgc cacttcgctc ccgaagctgc catgcccaac tgcaagagcc 1929961 taatatcaca ataaaaaacc gtctgaaatc aatccgattc cgtaaatggt atctgctaca 1930021 tccaactgct tattatctgc caaaaacacc agctcgtttc gctgatcaaa gatagtaaca 1930081 accagctata aatgtcatga tgccgaatgt ctctgtaatg tggaatcaat cttttaaccc 1930141 gagagcccct gaatcgcaca taaagaaaaa cgggaccact ttcttttatc agcatatgat 1930201 ataaacagct ctaagcagaa caaaaaaaga cacaagccaa aagcttatgt cttttatcac 1930261 aatctatatt attagtttaa gactttaaca cttacagttt tgacgcccca attagaagca 1930321 tcacttttac ttggtacaaa tacgtcgatt ttatttcctt taatagcgcc gccagtgtct 1930381 gctgctgttg cttccccgta gccttcaaca tagactttag aacctagcgg aattacatta 1930441 ggatcaaccg caataacttt cgcgttcggg ttcttattta agtcaatgcc tgtagctgta 1930501 acgccggaaa tgccgccgtc gttagcagtg taagcagtag cagtaactgt tagttctttt 1930561 gaagcttctt gattatttgt atttgattga acagccttct cctctgtgtt aacagaagtt 1930621 tctgcctcag cctttgtttc ttgtttaggt tgctgttgta cagcttcttg tttaggttgc 1930681 tctttttgca cagcctcttg ttttggcgca gcttgaggtg cgtttgtttg cgcattctca 1930741 gtagctgtgt ttgctgctgt tgcctgacct tttactgaaa gagttgatcc agcatagatc 1930801 atgtcagagc ttaagttatt ccaaactttc aggttgttga ctgtcgtgcc gaatttttga 1930861 gcaatcttag aaagcgtatc tcccgcttta attgtatatt gcccagtcgt ggttgtttct 1930921 tctgaagaaa tggtcagttt ttctcctgca atgattttat cagaagttaa cttgttccat 1930981 tcttttaagt cctttaggtt cactccattt ttctgagaga ttccccagag cgtatcaccc 1931041 ttttgcaccg taatttcttt tgcagaagcg tgagctccga atgcagttgt tgaaagtgca 1931101 gcaactgcca caaaggacat aatcgtcttc ttcataagta aatcctccct tgttagcttt 1931161 ttattggcgg ctaacaggtg atatcgtaac acacgtaaat gtcaaatcaa taacaaaaag 1931221 atatgattta gattacagtt cctttacatg aaggatttct ctctgatgga aagacttgct 1931281 gaacccttga tataataggc ttcgcaggtc tttttatttt gaggcgaaac agagaaaata 1931341 aaatgtgttt tttatagaaa aaaagattgt ttttctgttt ttttagtctg tcatccttgc 1931401 ataagcctgt atttcttgta aaaaaagccg gccgtatttt gctctttttt gttctccgac 1931461 tccttttata gacaaaagtt catcatcatt tacgggctgt tttcctgaca tttcttttaa 1931521 cgtttggtca gagaaaacaa caaatggcgg aacaccctgc tcagccgcaa tttctttccg 1931581 aaccatgcgc aatcgttcaa atagctcgtc attttcagta atcgctgccg cttttaacgc 1931641 ttcttttctc gctactgata attctccttt cagcacattc cttcctttac tgctgacaaa 1931701 aagagtcgga aacgttccgt ctgacatcct gatgaagtcg tcagaaataa gaaattcgat 1931761 aaaatcactg atttcgccaa cggattggtg ttttaatatc ccgtatgttg aaaggtcgga 1931821 aaagccgttt tcaagaactt ttttattttt ggagccggca agcacctggg caaccatcgt 1931881 cttgccaaac cgttctttca tgcgaatgat acaagataag accatttgcg cctcccgcgt 1931941 cacgtcatgg gccgctcttg tatcggtaca gtttccgcac tgtccgcacg catcaggctc 1932001 cttttctccg aaatacataa ggataaaacg ctgcagacaa tcttccgtat gacagtagtc 1932061 gaccatttgt ctcagctttt ttaaatcctg cttttgtttc tcttcatgtt ctgattgctc 1932121 aattaagaag cgctgcacca taatatcctg cggtgaaaac aggagaacac attcactggc 1932181 aagaccgtcc cgtccagctc gtcctgcctc ttgataatag ctttccatat ctttcgggat 1932241 ttgtgcatgc agaacaaatc tgatatttga tttatcaata cccattccaa aagcagaggt 1932301 tgccaccatc acttgaagct catcattaag aaatctttcc tgctgctctt ttctcacatc 1932361 atcagccaaa cctccatgat accggcctgc cctgacctga tttcgtttca atctctcata 1932421 tatccgatca gcttcttttc tggtcgctgt atagacaatt cctgcttcat gcctgttgtt 1932481 ttgcacatat tcgtctataa accgatcttt attttctcct tttactactt taaaggttaa 1932541 attctctcgg gaaaatccgg tatataccgt gttttctttt tgaatatgca gctgtttgca 1932601 aatatcatca tgaacctcgg gtgtggctgt tgctgttaac gccatgatga caggcttgtc 1932661 gtgtaattca cggaacaaga tttcaatatt cctgtagctt ggcctgaaat catggcccca 1932721 ttgagaaata caatgcgcct cgtctattgc gaccaaagga acatctatgc cctgcaaaat 1932781 ccggataaac tctatggacg ttagtcgctc tggtgtaatg taaaaaagct tataagcccc 1932841 ttctttgagt ccgttcagcc tctcatatat ttcctgattg gattgtgtgc tgttaatgta 1932901 ggcggcgtta atccccgctt cttctaacgc atcaacttga tccttcatca aggaaatcaa 1932961 cggtgaaatg acgatcgtcg tcccttcaaa cattaatgcc ggaatctgat agcaaatcga 1933021 tttgccgcct cccgtcggca taatgcaggc cgtattttgc ctcgcttccg tcaccaagcg 1933081 gatcgcttca tcttggccgc tccgaaactt ctcataacca aaataatgag ccagaaggga 1933141 ttgggctcta tgtaacataa cgtgtaaacc tcgcttttcc ttgaatttct cccatcatat 1933201 cataaaaaag cggccttcat ttctttcaca caaaaatgga atattcacta taccaaacct 1933261 ttttagataa aataaaaagc catttccgaa aaggaaatgg ctttcgctac gtcttgccgt 1933321 atgcaagtaa gaaagtttta aaccaccact cctcaaagtg ggtgtttgca gaaacgttcc 1933381 tgtcgtcctc tgcaatggag gcatgacatt ccggcttcga tataaaactc cctattacag 1933441 cttaaaggtt aaaacttaat taacaatacg cacaaagtag cttctttaat atagtacacc 1933501 atcaggcgct tttaatcaag aggtcagaac aattgtttag aaaaactttt tccagtgaat 1933561 aaaactgttt tttctccaaa atacctgaca attcgacaaa caaaaaatat attacaataa 1933621 aaaaaatagc ctttattgct aaaagcgaat gattattttc ttctatatta atgtgtatat 1933681 acaaaaagac tcctatttgt aacgatagga gtcttggctt tattagaatt ttgcagcaag 1933741 atcttttgct tcttgtaaac ctttttcaac gatttcttgc gcttgatcag gtgctgcgtt 1933801 atgtccttcg atgacaactg tgtgcaagtc ttgaacaccc cagaaaccaa gaactgtttt 1933861 catgaagttt aatgacattt caagtgcagc cattggtcct tctgagtaga caccgccgcg 1933921 agcgttaaga agcgcaactt ttttgccgcc cattaaaccg actggtcctt cttgtgtgta 1933981 tttgaatgta acgcctgcgc gagacagata atcaacataa gtatgaagca ctgctggcac 1934041 tgtgaagttc caaagcggga atgcgaaaac aactttgtca gcttttacaa actggttcag 1934101 atatttgtca gcaattgctg cttgtttttt ctcatcttct gtcatttcca ttccttgacc 1934161 tgctttaaat gttccgttaa tcatatctct gccaaggtaa ggaaggtttt ccttatgaag 1934221 atctaattca accacttcat cattagggtt gttttcttta taagcagcta agaaagcttc 1934281 gtaaagttta gttgaaacgc cttcttcagc tgtacggtcg cttgatttta caaataaaac 1934341 tgtagacatt tgtattcctc ccggtaaact ttttatattt acttacaaat agtatgttac 1934401 tttctttttt acgtaaagtc aatcacttta ttttgaatat gagatttttt ttcaaaaaaa 1934461 agcaagtaca tctaatatcg gtgtacttgc ttggcatttt tacttcgaat cttgttcacg 1934521 atccaagatt tcatacgtct gcgagctttt ttgatcaatt gtttctttgt tggataagtc 1934581 ttttacctgt tcatgaaact ctctttcata agaaggagca tctgtctcca gatcatcctc 1934641 cacatcagct tgggcctcaa ctgtcattct tgcataagga acagcttcaa gtctttcgta 1934701 aggaatctct tggccggttt tttcacacac gccataagtt ccgtctttca tcttttgtaa 1934761 tgcacggttg acctcctcta acagctcccg gtcaatctct ttcactgttt ggtctgtcat 1934821 ccggtctgtg acgagcgtcc cgtggtctgc catatggttg tcaaccccat tggaaagctc 1934881 ccccacttct tccgtcattg attctgtttc ctttttctcg ccagacaatt ctttttgcat 1934941 atcgagcaat ttatgataga gatgctgtgt ttgttctttt gtcagtgcca tgtatatcct 1935001 ctcctttcta tcctgtttcc cgttttgcct tctgtcaaac atggaaacat cgatggaaag 1935061 atgagctact gcctttttga acggatcgtg accgctggcg tcgatggtgc ttcgggtttt 1935121 cgttggcact ttttgtcctt ctcttctggc ggtatataat aggttgcgcc tatatttaat 1935181 ctgccgctca gttcatcaat ggtcagctcg ccgaattcaa gatgatagtc aactttttcg 1935241 acattcagcg tttcaatatg tatataggtt tcttcagact cttgtttgct gctttgtttt 1935301 tgtttctcaa tcactgagag tctttcttca cattcacgca gtttgtcaag ttctggtttc 1935361 aagcaatgcc tgatcagcga ccggaacatt tttttcatga catcacgacc ctttgcatac 1935421 tcctctttcg tctacatata taatgaggta tatcccatag aaaggagagg ttttcatgct 1935481 tccgactaac atcaatattt ctcatctcaa gactaactcg ataggcaccg gctcatccct 1935541 tacctttggt tctgcggagt taaggaacag gtgctctgct atcaaaagaa ataacggttt 1935601 tggggaacaa aatgcagatg gtattgttat ggtcattccg attgaatcaa ttgatgaccg 1935661 tgatgtgtca gatgcactca gtatgaaaat caatcatcaa taacaatggt tttcgcttga 1935721 ccttcgtctt tttgaatagt gatgtatagg attccgtctt taaaaatggc attcatcttt 1935781 ccatgaagat gatcggaaag cggaattttc ttttcaaaac ttccgtattt cccttctttt 1935841 tggcgaaagt cctgttcatt aaaataggaa aagcgctgcc ccttcaccac taaataatct 1935901 ccgtacgata atatgtgaac gtcttgttta cggtagcctg gaagataaat taaaaactgc 1935961 acttccgcaa cggtatctac aatatccatg ctcggaaatg aagcatctcc tttccctcgc 1936021 tgatcttgct gcgcaaacgg aaacggagat tggccatttg tcataaaagg ggttttttgg 1936081 tcttcatcaa atacctgttt ccaaaagtca ccgccgtaca tctgctgtgc gaattccatc 1936141 cactgcttca tcttttcgaa atccatttga agccccctgt cttaacatac tttataaccg 1936201 ccagcataca actatagaaa ggaggtttgc ctgtggttca accaactccg tatatcaata 1936261 ttaatatttt catgctgaaa attaattcct ttgaaaatgc ttcagcggtt aacgtaggac 1936321 aaaatttatt ggcagaatgg caaaattcag ataaaaaaaa tcaaggctac ggacagaatt 1936381 ttggagatgc gagcggattt atgggcacga gaagccatgt ggatgacaga gaccaaattg 1936441 attctccggc ctcttttgaa agtgaagcgg ttaactcctc aatcaaaagg aagtgatgag 1936501 atgttctttt caccctccgt cgtaaatgtc ggcggattta aaatcaatac gatggatcga 1936561 ggttcctctt taacactcgg tccgtatcag caggtcgatt actttttatc agctaaaata 1936621 aatcaagggt ttggagaaga aaatggcgac tttactcctc ttgtcgtgcc gatttcaaat 1936681 gtattagatg cagatcttgt tgattcgaac tcagcgaaaa acagtgtggt gtaataagaa 1936741 cagggcgcac atgccctgtt cttgttttta tatataaaaa aagcctaacc attttttgaa 1936801 cggctggctc atcaaatatt cagctgcaca aatgctttgt cagcaccgcc tgaacctcgc 1936861 ttaaatcggt gtctttcgca aattctaatt cgaaagtttt gcttcttgtc atcaataaaa 1936921 gcccagtgtc cggatcaaac attcccgctt cttggatggc aaagctttca attgttttat 1936981 atggaagaaa tacacgaacc ttctttttag aaaacatttt attgtcaaag aaaatgatcc 1937041 gcttatttgt aaagcaaatt tggtccactc ggagcttata aatcgattca attctttccc 1937101 cttcaacgag caaagcctca agcttctttg cgtccgttga tctgctaaca gaaaaaatac 1937161 ccaatgaaga acccctcttt ctgcatttat ctatttgttt tatcattcac tacataaaaa 1937221 taagtccttt atccctatat aagaatacga catagaagac atttaaacca ttacgaacag 1937281 attacatttt tcaaattttt gatttgtttt ttggctttta agctgttgtc atcaagtaat 1937341 acgcacatat agagaaaaaa gtttcaatat tcagcaatgt ttttataaaa aagtggtttt 1937401 taatgatttt tttaattttg ttttatattt cctgttttaa ccacaaaaaa accgcagctg 1937461 agctgcggtt ttatgtatcg actgctttta acaaaatctg tttgatgctt caaggaagca 1937521 ttacatctct tcgaagtatt ctttataata gccgccgact ttattcgtat tgtcgaccac 1937581 aaagagaaac tcctctgttt cattttttac ttcatattct tttcccggcg ttaaaacgcg 1937641 gtttacgata tatttttttg cgtttgtctg cacacacttt acttttttaa tggtttcttt 1937701 ttcaagccaa tttttatgaa tcatgatgaa atctcctttt cttatctata agcttattgt 1937761 agcttttttc ttttgtaaat tgcaatatcg gttattcatt gattttgcct tgatttctat 1937821 tatagaatgt ttgtatacgc ttacgtttga agcaactatc acagcttatt tctgctattc 1937881 aatccaggaa tcaatgtgct atcaccaaga atctcagaac agaccataaa aaatgactgg 1937941 aggtttgtta cggatgagtt ctttaacgat gcaagtgacg aaaaggctgg agacattttt 1938001 acagggaaca aagaagcttt atattgacgg aaagtttgtt ccgagtgcct caggggcaac 1938061 ctttgacact ccaaacccgg cgaccggcga aaccttgatg acgctgtatg aagcccaggc 1938121 tgcggatgtg gacaaagctg ttaaagctgc ccggaaagcc tttgaccaag gtgaatggag 1938181 aacaatgtct ccagcttcga gaagcagact gatgtataag ctggcagact taatggaaga 1938241 gcataaaact gagcttgctc agcttgaaac acttgataat gggaaaccga tcaatgaaac 1938301 gactaatgga gatattccgc tggctattga gcatatgcgc tattacgccg gctggtgtac 1938361 aaaaataaca ggacagacga ttccggtttc cggcgcttat tttaattata cgcgtcatga 1938421 gcctgtcggt gtcgtcggcc agatcattcc atggaatttc ccgctcctga tggcgatgtg 1938481 gaaaatgggc gcggcacttg caacaggctg tacaatcgtc ctcaaaccgg ctgaacaaac 1938541 accgctttca gctctttatt tggcagaatt aattgaccaa gccggtttcc ctgccggtgt 1938601 aatcaacatc atcccaggat tcggtgaaga tgcgggagaa gcgctgacga accacgaagc 1938661 ggttgataaa attgccttta ccggttccac tgaaatcgga aagaaaatca tgtccaccgc 1938721 agcgaaaagc attaagcgtg tgacattgga gctgggcgga aaatcgccta atattcttct 1938781 gccggatgcg aatttaaaaa aagccatccc gggcgcttta aacggtgtga tgtttaacca 1938841 gggccaagtc tgctgtgcgg gctcacgtgt cttcattcat aaagaccaat atgatgaagt 1938901 tgttgatgaa atggcatcct atgctgagtc actccgccaa ggagcgggac ttcataaaga 1938961 tactcaaatc gggcctctcg taagcaagga acagcatgag cgcgttcttt cctatattca 1939021 aaaaggaaaa gatgaaggag caaaagcagt gaccggcgga agctgtcctt ttgaagcagg 1939081 atattttgtc gcaccgactg tgtttgcgaa tgttgaagac gaaatgacca tcgcaaaaga 1939141 agaaattttc ggacccgtgc tgactgcaat tccgtacgaa acagtcgatg aagttattga 1939201 acgggcaaac cattcagaat atgggcttgc agccggacta tggacagaga acgtcaagca 1939261 ggctcactat atcgcggacc gacttcaagc cggaaccgtt tgggtcaact gctataatgt 1939321 gtttgacgcg gcgtctccat ttggcggtta taaacagtca ggactcggac gagaaatggg 1939381 atcatatgcc ttggataatt acacagaagt caaaagtgta tgggtaaacc ttgaagacta 1939441 acatgtatgt ttaaaaaact gctgcctgcc agcagttttt ttctttctgt aatggcagta 1939501 aaagacgctg aatatatatg cttctgaagg agttgagcgt gatgggcaca cttcaggaga 1939561 aagtgaggcg ttttcaaaag aaaaccatta ccgagttaag agacaggcaa aatgctgatg 1939621 gttcatggac attttgcttt gaaggaccaa tcatgacaaa ttcctttttt attttgctcc 1939681 ttacctcact agatgaaggc gaaaatgaaa aagaactgat atcatccctt gcagccggca 1939741 ttcatgcaaa acagcagcca gacggcacat ttatcaacta tcccgatgaa acgcgcggaa 1939801 atctaacggc taccgtccaa ggatatgtcg ggatgctggc ttcaggatgt tttcacagaa 1939861 ctgagccgca catgaagaaa gctgaacaat ttatcatctc acatggcggt ttgagacatg 1939921 ttcattttat gacaaaatgg atgcttgccg cgaacgggct ttatccttgg cctgctttgt 1939981 atttaccatt atcactcatg gcgctccccc caacattgcc gattcatttc tatcagttca 1940041 gctcatatgc ccgtattcat tttgctccta tggctgtaac actcaatcag cgatttgtcc 1940101 ttattaaccg caatatttca tctcttcacc atctcgatcc gcacatgaca aaaaatcctt 1940161 tcacttggct tcggtctgat gctttcgaag aaagagatct cacgtctatt ttgttacatt 1940221 ggaaacgcgt ttttcatgca ccatttgctt ttcagcagct gggcctacag acagctaaaa 1940281 cgtatatgct ggaccggatt gaaaaagatg gaacattata cagctatgcg agcgcaacca 1940341 tatatatggt ttacagcctt ctgtcacttg gtgtgtcacg ctattctcct attatcagga 1940401 gggcgattac cggcattaaa tcactggtga ctaaatgcaa cgggattcct tatctggaaa 1940461 actctacttc aactgtttgg gatacagctt taataagcta tgcccttcaa aaaaatggtg 1940521 tgaccgaaac ggatggctct gttacaaaag cagccgactt tttgctagaa cgccagcata 1940581 ccaaaatagc agattggtct gtcaaaaatc caaattcagt tcctggcggc tgggggtttt 1940641 caaacattaa tacaaataac cctgactgtg acgacactac agccgtttta aaggcgattc 1940701 cccgcaatca ttctcctgca gcatgggagc ggggggtatc ttggctttta tcgatgcaaa 1940761 acaatgacgg cggattttct gctttcgaaa aaaatgtgaa ccatccactg atccgccttc 1940821 tgccgcttga atccgccgag gacgctgcag ttgacccttc aaccgccgac ctcaccggac 1940881 gtgtactgca ctttttaggc gagaaagttg gcttcacaga aaaacatcaa catattcaac 1940941 gcgcagtgaa gtggcttttc gaacatcagg aacaaaatgg gtcttggtac ggcagatggg 1941001 gtgtttgcta catttacggc acttgggctg ctcttactgg tatgcatgca tgcggggttg 1941061 accgaaagca tcccggtata caaaaggctc tgcgttggct caaatccata caaaatgatg 1941121 acggaagctg gggagaatcc tgcaaaagcg ccgaaatcaa aacatatgta ccgcttcata 1941181 gaggaaccat tgtacaaacg gcctgggctt tagacgcttt gctcacatat gaaaattccg 1941241 aacatccgtc tgttgtgaaa ggcatgcaat accttaccga cagcagttcg catagcgccg 1941301 atagcctcgc gtatccagca gggatcggat tgccgaagca attttatatt cgctatcaca 1941361 gttatccata tgtattctct ttgctggctg tcgggaagta tttagattct attgaaaagg 1941421 agacagcaaa tgaaacgtga atcttatcaa gcggagatgt tcaattggtg tgaagccctg 1941481 aaagatcaga ttcaaaagcg aggtcagctt gaccagtttg aagatcaaat cgacaagatg 1941541 attgaggctc tggaagatga ccaaacaaca gaagaagatt ggtataaaca ggccgctgcc 1941601 ctttatcggg atattacaga atcagatgat acaagtgaaa gacgcgctta tgtccctata 1941661 gggaaacacg tgctgccaaa gcttccttac aaatactccg ccttagaacc ttatatatca 1941721 cgcgatatta tgatccttca tcatacaaaa catcatcaaa gctatgtcga tggcctgaac 1941781 aaagcagaat cagagcttaa aaaagcgaga gcgacaaaga attatgactt aatcactcat 1941841 tgggaaagag agcttgcgtt ccatggagca ggccattatt tgcatagtat tttttggttt 1941901 tctatgcatc caaacggaaa acggcgtcct acaggggcat tgttccaaat gatagacctt 1941961 tcatttggaa gctattccgc ttttaaagaa cattttaccc aggcctctaa aaaagtggaa 1942021 ggcgtcggct gggccattct ggtctgggca cctcgatcag gacggctgga gattttaacg 1942081 gcagaaaaac accagctctt tagccaatgg gatgtgatcc cccttttacc gcttgacgta 1942141 tgggagcatg cctactattt gcaatacaaa aatgaccggg ccagctatgt cgatcactgg 1942201 tggaatgtcg tggattggcg cgaggctgaa aaacgttttg agcaggcaaa agaagtcgtt 1942261 tggaagctct attaaaaaaa gccccctttc ctcgggggct tcgtgtgtta aaaaatacct 1942321 atcacatgca aaaacacgat gatgatggca acaggagata gatatcgaat gagcagcagc 1942381 caaaccgcaa accactttcg tttgagattg gaaccgcttt tcagctcgtc aaacaaatcc 1942441 tgtttcggta tttttagcgg aacaaaaatc gaaatcagta acgcacctaa cggcattaaa 1942501 atattgctca caagatagtc agccgcatca aaaatagaca gatgaaatat agtgacgtca 1942561 cttaagacac cgtatgataa tgcagacggc acaccgacaa taaaaatagc aataccgcct 1942621 aaccaagcga atcgttttct cttattgata tcgcctttcg acagtactgc gaccaaaatt 1942681 tccagcattg aaaaagcaga tgtcaatgca gcaaataaaa atagaagtaa aaatgctaat 1942741 aaaaagataa ttccgaacgg catttgatta aacacagtcg gcagaacgtt aaataacaga 1942801 accgggcctt ggtctggctt gaggccgaat gaaaatacag ctggaaaaat cgcaattccg 1942861 gccattacag caacaagcat gttcataaca gttacagata cagcggactg taccagattt 1942921 tcctgtttct ctaaataagc gctatacgtt accatgacag atacaccgac acttaataag 1942981 aaaaaggatt gtcccattgc atataaaatg gtattggcat caattgcagt taaatcaggc 1943041 atgaggaaaa atttgattcc ttccatcgcg ccatcaagtg taaccgaacg caccattaaa 1943101 atgatgaata atagaaaaag cgccggcatt aatacttggc ttgctttttc aattccgctg 1943161 cttacccctt ttgcaacaac taaaattgtt accaccataa agagcagctg gcctcctaca 1943221 gccaaataag gatttgaaat ggtacttgca aatatcgtat caaaaccaga tgtttgcgat 1943281 aaaccgccag tgaagccttt tataatataa attaaaatcc atccgcctac gacactgtag 1943341 aaagatagaa gaataaagca cgtcaccatg cctaaataac cgatccaatg ccacttcgtt 1943401 cctggagcaa gtgttttata ggactgaacg gcatctttct gtgttcttct gcctatgatg 1943461 aattcaccta acaataaagg cagtccgatt aaaaccgtaa ataaaataaa aataagtaaa 1943521 aatgcgcctc ctccgctggt tccggcaaca tatgggaatt tccatatcgc accaagcccg 1943581 atagctgatc ctgccgcggc taaaataaag ccgagcttcg aagaccattg atttgcttcc 1943641 ttcaccgtat cactcctatt tgatctaacc attataaagg ttcattgtaa gaatatcttc 1943701 ctatatagtc aagaacattt taattagttt acatcatata tctatagaca tctgccaaaa 1943761 actaatattg aattattcag aaaattattt ataataagag aatgttatga aatttgtaag 1943821 aatttctgct gaagttcttg ataagtgtgt taggagtgtt tttatggaca tcattagaaa 1943881 aataagccat tttgcaggac aaacctttgg catatgggtc attgtttttg cagtgctggg 1943941 attttctttc ccatctttat ttacgtggat cagttcttat attacgattt ttctcggcat 1944001 tatcatgttt gggatgggcc ttacactgca agccgatgat ttcaaagagc tggtcagaaa 1944061 gccttggcaa gttattattg gagtaatagc tcagtatacg atcatgccgc tcgttgcttt 1944121 cggcctcgca tttgggcttc atcttccagc tgaaatcgca gttggtgtta ttcttgtcgg 1944181 ctgctgtccc gggggaactg catctaatgt tatgacattc ttagcaaaag gaaatactgc 1944241 cctttctgtt gcggttacga caatttctac cttattggca cctgttgtaa caccgttgtt 1944301 gattatgctg tttgccaaag aatggcttcc tgtctcgccg gggtctttgt ttatctcaat 1944361 cttacaggcg gttttatttc cgatcattgc aggtctgatt gtcaaaatgt ttttcagaaa 1944421 acaagtggca aaagccgtac atgcccttcc gcttgtttct gtcattggca tcgttgcgat 1944481 tgtctcagct gtcgtcagcg gcaatcggga aaatctgctt caatcggggt tgctcatttt 1944541 ttcagttgtt atcctgcata acggtatcgg ttatttactg gggtttcttt gtgcaaagct 1944601 tttaaaaatg gattacccgt ctcaaaaagc gattgcaatc gaagtcggca tgcaaaactc 1944661 cgggcttggg gctgcacttg ccacggctca tttctcaccg ctatctgccg taccaagcgc 1944721 aatattcagt gtgtggcata acctttcagg ttctatgctt gcaacatatt ggtcaaaaaa 1944781 agtgaaaaag aagcaagctg gatccaaaag cagcaatcta tcactttaaa tatgcatcaa 1944841 aaagggtaca tcactttatc gtgatgtacc cttttttatt atccttctaa taaaagctgt 1944901 tcaggatctt ccagtaaatt tttgattgtc acgaggaaac caaccgcttc tttaccgtct 1944961 acaattcggt gatcataaga taaagcgata tacatcatcg gacggttttc gaaacgctct 1945021 tcatcaatgg ctacagggcg cagctgaatc ttatgcatgc ccagtatacc gacttgcggg 1945081 ctgtttaaaa ttggagttga catcaatgaa ccgaaagtcc ctccgtttgt aatcgtgaag 1945141 gagcctccct gaagctcgct aagggttaat ttattgtttc ttgctttttt cgcaagctcg 1945201 ccgatctctt tttcgattcc tgcaaatgtc aggcgatccg catcccgtac aaccggaacg 1945261 acaagacctt catcagcagc aacagcgatt ccgatatcgt agaatttttt aacgatcaac 1945321 tcatcgcctt gaatttctgc attcaacagc ggatattttt tcaatgcagc cacgaccgct 1945381 ttcgtgaaga aagacataaa gccgagcttc acttcatttt gctcaaaaaa ttgatctttg 1945441 cggcgttttc tgagattcat gacagccgtc atgtccactt cattaaatgt agtcagcatc 1945501 gctgatgttt gctgtacctc tacaaggcgt tttgcaatcg tttgtctgcg gcgtgacatt 1945561 ttttgcactt caacaggttt gtcaaagctt tgctgtgctt tttgagcctg aggctgctgc 1945621 ttttgctgag gagccggttt tgatgccggt ttttcgtacg cttcgacatc ctgcttgcgc 1945681 actcttccaa gcggatctcc agttggaact tgagacaggt caattccttt ttctctcgca 1945741 agcttacggg ccgacggaga agcgatcgtt cttgattttg cttcagattg tgcttcctcg 1945801 ctcacctctt gtgcagctgg ttcagcctgt ttctcttctt ttacgctttc cttgctttct 1945861 gttttctctg taggagcagg ggcagaactt tcacccgcgc cttctgaaat cgtaccgata 1945921 atttctccga cctggacggt atcacccgaa tctttcaata cctcttgaag tacacccgat 1945981 tcttctgctg tcaattcaac attcacttta tccgtttcta gttcaagcag atattcaccc 1946041 tgttctacat agtcaccagg ctgctttaac cattgggcta ttgttccttc tgagattgat 1946101 tctgctaatt caggtacctt aatttccgcc attttttcat ttccccctta gtttttgcga 1946161 gtcaagctat cagatacaat acgttcctgt tcttttttat gaactgtcgg atctccctct 1946221 gcagggctgg atcgtcttct tcgtccaata tattgaacgc ttactccctc tggtgcaatc 1946281 tctgtcaaat acgggctgat ataaccccaa gcccccatgt tctgcggctc ttcctgcacc 1946341 caaacgattt ctttcaggtt cggaagtttt gcaaataatt ctttgactcc ttttgccggg 1946401 aatggataca gctgttcgat tctcgcaatg tgaagccact ctttaccgtc ttctaactta 1946461 ttaaaatgat cgctaatgtc tatagacact ttaccgctgg ataatacaag tctggttact 1946521 ttttcatagt catgagaaag tcccgactgt tcataaacag gctggaagcg gctttcgctg 1946581 agctcctgca cttccgacac cgtatttggg ttgcgaagaa ggctcttcgg cgtcataatg 1946641 acgagcggtc tgatttcttc acgaagcagc attttagcct gtcttcttaa aatatggaaa 1946701 tactgtgccg cgcttgtcag gttggcaacc gtccagttgt tttccgctgc aagctgcagg 1946761 aatcgctcaa ttcttccgct tgagtgctca ggcccctgtc cctcgtaacc gtgcgggagc 1946821 agcatgacta atccggattt ttggccccat ttcgcgcgtc cggcagaaat aaattggtca 1946881 aaatacactt gagcagcgtt ggcaaaatct ccgtactgtg cttcccacaa aacaagcgtt 1946941 tccggtgaat gcacgttata gccgtattca aaaccgagaa ccgatccttc agacagcggg 1947001 ctgttatgaa cagcaaatga tgtgctgcag tcagataagt gatgaagcgg cacaaattct 1947061 ttgcccgtct cactgtcatg aagcacaagg tttctttggg cgaacgttcc gcgctcggaa 1947121 tcctgtcctg ttaaacgaat cggtgttccg tctttcaaaa ttgaagcaaa cgcgagtgat 1947181 tctgccaaag accattccac ttttctgtca tcatcgaacg ccttggcgcg tctttctaaa 1947241 atgcgcttta gcttgccgaa aacattaaat gactccggcc agttgatcaa ttcgccattc 1947301 agcttgcgga gcacatcaaa atcaatcgaa gtgtccacat ctgggaaacc gtttgataca 1947361 ggctctggaa gttcaatttc acaagcagtg tgttcctttt tagacggaac tttctgatat 1947421 gcatcctcaa tgcgcttcgt taccgatttt tcgatgtttt gaacgacttc ctcggtaacc 1947481 acgccttctt ttaccagctt ttcagcgaaa atttgtttga cggtcggatg ctttctgaca 1947541 gcatcataca gcattggctg agtggttgac ggttcatcca tttcgttgtg tccatagcgt 1947601 ctgtacccga tcaaatcaat cagaaaatcc ttgttgaatg tttttcggta ttcgaccgca 1947661 aacttaacag ctgaaagaca agcttcagga tcgtccgcat tcacgtgaac aatcggaatt 1947721 tcataaccct tggccaggtc gctggcatat tttgtcgatc tggattcagc gctttctgtt 1947781 gtgaatccga tcatgttatt ggcgataata tgaatcgcac cgcctacttg ataccctttt 1947841 aaagagctta aattcaatgt ttcagctaca attccttccc cagggaatgc agcgtctcca 1947901 tggattaaaa tggccagcga ttttgtttca tcttgtaccg ggtatccgct ttgtgttcgc 1947961 gtttcctgtg ccgctcttgt gctgccttca acaatcggat tgataaattc caagtggctc 1948021 gggttgttcg ctaacgtaat gcgcgctgat tttgtttcag cgtcttgaag ctcccgattc 1948081 gcccccaaat ggtatttgac atcccccgtc catccgtagc tgattccaat ggatccctca 1948141 gacggtacaa gatctttgtt cggcgcatgc tggaattcag agaagatgat ttcatacggt 1948201 ttgccgagca catgtgccaa gacattcagg cgtcccctgt gcgccatccc gatgttgaca 1948261 cttgtcgtgc ctgatttgac agattgtgca ataatgtcat caagcactgg aacaagagcg 1948321 tccagaccct caatggaaaa gcgcttctgc ccgacgaatg tgcggtgcaa aaactgctca 1948381 aagccctcta cttctgtcaa tctttccagc acagctgaca gcttttcagc tgagttcttc 1948441 tggaacagct cgccagattc aatctttctt gtcagccact cgcgctcttt gaagtcatgc 1948501 acatggtcaa attcaaaaga gatggttctt ttatacgtat ttcgtaaata ctgaatggct 1948561 tctaaaccgt tcgaaatgtt tttaggagcg tctttgcaga tgacagacgc aggtattgct 1948621 tttatttcct cttctgttag cccgtaatcg gataatggaa aaagttcgct ctttttctca 1948681 tcctttctga gcggattgac ggaagcgttc aaatggccat aggttcggat atcttctgca 1948741 agtctgactg cggatgcgat cttttgaatc agatcggctg taacacgtcc cttttctttt 1948801 gttcccgagg cctcttttat atcgcttggc ggagcaccga gctcgtcgaa catttccttc 1948861 aaatccgggt caatgctgtt cggatcctgg gtatactgat cgtaaagctc cagcgcatag 1948921 ccgaggttcg gaccgtaaaa atcttcccaa ttcattcgtt gtttcatact attttgaaac 1948981 atttgaatat tacccccaac ttaaataatc aagtgattga ttcactatct tgaaataact 1949041 ttcgaacgct gtgtccaaaa ttatgtaata aaaacgcttc caacgatatt ttaccactgt 1949101 ttgcaatttg attctacctt gattgttcac aaaatagtaa aaaaccttta taaaaaacaa 1949161 aaaatttaat cattcgaaaa aacaaacgcc aaaaagcata ggattaaggg ctatcctatg 1949221 cttttatgaa gcagtttttt cagcagcgga tacaaaacat ccggtagctg atcaacatcc 1949281 gggacaaata tactgaattt tccgtacata tcctggatcg tcttcatttg cgattcttct 1949341 atttctgagt tggagagaaa aacatttatc acttctattc ctctttttcg ggcttcgata 1949401 accgcctcac ttgtatcaac gatcccattt tgttcgtagc caaatgcggc cggctctcca 1949461 tctgagaaaa caattaagaa cttttgcgcc tcgctgcgat gcagcatttt tttcgtcatc 1949521 tgcctaattg cgtacccgtc acggttatct tcttctggct caagctgcat aatggccggt 1949581 ccagaatctt gtcttaatga tgattggaag ggaataaccg tattgaaata gtttggctgg 1949641 cttttttcgg ttgcatcatt tgtgtcctcc caaaaaccga caatctgatg cggaaccgct 1949701 accgatttca acgcttcgtg aaacagcacg attcctcgtt ttgtttcgtc cattttgtcg 1949761 aacatgctgg cggaacaatc gaccagcaat gtaaaaactg cgtcgatttc tgaagatggt 1949821 tcttgctttt tgtagaacag gcgcggattt cgctcagtga agtaacgaag aagcttattg 1949881 ttcagtctcc cggcatgaag gtctgttctc ggcaatgttt ttttatgctc cagcgttttt 1949941 tgaatcattt gtttcaaacg cttttgatac gattcaatcg tttttgcctg ctgtttataa 1950001 gaaagctctt cttcactggt tgccggctgc ggttctttat aaattggaaa tgcatattta 1950061 ttttctttgc cgtcagccat acccgctccg ttcggctggt ctttttggga ctccagcgct 1950121 tccagcttgg aatagtcttt ccgtttcgtt tgtctggctg atccttgaac agagccaagg 1950181 gcctgatctc catcgtcgcc ttcccttgaa gcatcttttc ctaaatctga ttttgcgccg 1950241 tgttcaatat caaattgaag gaagctttta gacggtgctt ctgtttcccg gtgccatgtc 1950301 ggcatttctt cttcatggat atcctcatca ccgtctgatt gttttggaag cgtgatgtca 1950361 tcactcagct tcggcgcttt tttctcttct tcaaataacg gctgttctgc agcttttgcg 1950421 taatcaagct caggcaaaaa gaagtaggtg ttcaacatgt ctttatcgag tacctcttca 1950481 agtccgtcca tgaggtcctc aacaattttc agaacctgcc gtgtcgaatc tgcttcatac 1950541 acacgcaaga gctgctgctc aataaacggg cgcatcagat cgatatcttc acgcatggat 1950601 ggaagggtct cgagcggcga ttccgctgtg agcttgaaat agatcgcgca aaagagcgca 1950661 tcggtaaaaa tgcttcgttc caaatttaag gtcagctggg ttgagaaatg ttttctgtac 1950721 atgtcttttc gcttcgcaaa tacatgtttc gtacccgggc gctcacgttt gatgcattct 1950781 tcgatcctaa tgtcttcaag cagcataaag agctgcttgg caaaactttt aaacgtaaga 1950841 tggcgatgga tatcattcaa aaagttcgca aactcatgca gcgagctata tcttgttccg 1950901 actgaacgca ggtagacgtc gcttttcaga cccgcttcca tgtcctcagc tgccctgtct 1950961 ttccaaaagt ggctcatata gattttcttt tcaaatggat tgtaatagga ctgaacgcca 1951021 tactccactt ctaccgcttc actcttggtg agtgttttgg ccaaatcagt cagcatcata 1951081 aataaaaatg aatcaatcgt gctgtcgtta aatttgataa atttcatcgc agccccctca 1951141 ttcaaacaga gtttctgcaa tatttcggac agccgctttt tcccgatcat catcaagctt 1951201 ttctacaatt ccccgctcaa tggcacgacg cggcggaata taagcagcta aatcacatgt 1951261 atcgattaaa gctctgatgg atgccgcttc ttcagacacc tgtccgttat tggcctgaac 1951321 gatcaagtca gaggaaagcg tgataaatct gtcaatcaat ttctcgtctt tcaaggctga 1951381 ctgagacatg agcacttgtt tcagcagctc gcctttaata taaggcacat caatgatgac 1951441 aaaacggttt ttcaacgctt cattcagagg aacagttccg acatagcctt cattgatggc 1951501 tgcaatgact ccgaaaccgc ttttagcccg tatgacctcg cctgtaaacg gatttgtcat 1951561 catttttctg taatctaata caccgtttag aataggcagt gtttccggct tcgccatatt 1951621 gatttcatct atataaagaa aatggccttc cttcattgcc tttgtaacag gtcctgaaac 1951681 aaactcgatt gttgcctggc cagattgatt ttcaatcgtt ttataaccga ccaatgcctc 1951741 agcgtccaag tcgactgaac agttgacgct gtgcatcggt ttatgaaaat agctggacaa 1951801 tgtttctgcc agctttgttt ttcctgaacc tgtaggccct ttcagcagga catttttccc 1951861 catggctaat gcaataatgg cgtcaaataa aatggcttca tcctccgcct catagcctga 1951921 tgttcctata agcgattgaa actctgggga aataggctgc tctttatatg ataaaagctt 1951981 ttgttgtata tcttccggca atgttaagtg ctgtagttga gttgtcatag acagattccc 1952041 tttcctattc atattccatt aacgagtata ctaaaaaagc ccctgtatgc tcaatacaaa 1952101 agggcctgga tgatattact gcttctcgtt atttcccaaa agggctccgc agacaatacg 1952161 cgcaccggaa ttgccgcttg ggtttgtcag ataatcgtcc gcttgttcat gaataataaa 1952221 tgcacttccg tcctcgtcga gaatatttag tttacttcct tttttcagtg aagtgtcagg 1952281 cgcattcatt atgacatcta cctttccatc agcaccgact tcaaggttcg gcagatctcc 1952341 ggcatgatgc cccatcggat tattaaagcc gtgttctttg ttcagtggat taaagggacc 1952401 gcccgctgat tcaaaatccg gcctgacaca agaacctttc tcataaatat gaaaaccgag 1952461 agaagcacct ggacgcaggc tgtttgcgga aatatgaata tcgaggcctt catcatctga 1952521 ttctttgatc tctataaaac cgactgcttt cccttcacga ttgaccagct ggacatgatg 1952581 accaaacgct gacgtttcaa ccactttttt ttccggcacc cggttaggag ggtctggagg 1952641 ttttttttgt ccgcatccgg caactcccag tgccgtcagc atcatcaaca gcaagagacg 1952701 gtgcatactg tctccccctt gttttttcta acagtgtggt caatcattgt ctggtataaa 1952761 caaaaaagcc tataaaaggc tttttgtcat actcattttt aaaaataact tcttgcgccc 1952821 aagtaccgct gtttccaata cgaattgctg agattggaaa tgtcgacgcc cgatgagctt 1952881 gcatgaataa aatcaccgcc gcctagataa atccccatgt gagacgggcc ggatttatat 1952941 gtggtaaaga agacaaagtc tcctactgac ggctggctga ctttctgcat gacattccaa 1953001 taccctgccg tactcaatct tgatatagat gatacattat taatgaggta ataaatgaag 1953061 ccgctgcaat caaaaccggc aggcgtgttt ccgccccatc ggtaaggcac tccgacatat 1953121 tttttcgctt ccgttatcat tctgtcaatc ttcgaaccta tttgaatgtt tgaccctgag 1953181 ttatcttttg gctttgttgg ctttgtcgga tttgaaggat tagattttga tgctcccgaa 1953241 atagtcagaa cctgcccgat ttgcaacaca tccgatgata aattgttttt atcacggatg 1953301 ctttggacag tgactccgag ccgatttgca attttccaca gcgaatcgcc tgcttttacc 1953361 ttgtacgtcg ttgtttttga gggattggag tttgacggct ttttggaacc gctgtttccg 1953421 ttcttaggtg aactgcttcc ttttattttg agcacctgtt taggataaag tgtatctgat 1953481 gttaagccat ttaaggtttt taattcggct acagtcatat ttaagctgtt tgcgattttc 1953541 cacagtgagt caccaagctt gaccgtatat gtactttttg aagaacctga agaattggaa 1953601 ccgctgtttt tctttgatcc atttgatccg cttgaactgc ttgtcccttt gatcttaagc 1953661 ttttgccccg gacgaatcag gtcactgctc aggctgttta agcttttaag ctcagaaaca 1953721 ctcattttat gatttttagc aatcatccat agggaatcac catatgcaac tgtgtatgtt 1953781 gatgttttgc ttgaattaga tggggatgtc gtgctttttt tgctgctttc aggaacctta 1953841 agactttgtc cgacataaag caccgttgat ttcaatttgt tttcggattt cagagctgat 1953901 attgtcgtat catactggcg ggaaagtttc caaagagagt caccgctttt tacttttatc 1953961 gtttttgctt ccgcgggtgc tgcggccatc gacgacccaa caactgcaga aacagccaag 1954021 ccggctacaa tcttcttttt cattcattca acctcctaaa ctgttttttt gcaaaaacag 1954081 ctagtatttt gtttccaaaa atggcacaca actgttttat cgtcaatttt tcagcaagtt 1954141 aaaccctttt caaacatttg gcgcagcatt ttcagcatcg ttcgaccttt aaaccttcaa 1954201 ataaacatct aacattttac ataagcacga tatgtttttc gaaagtctaa ggaactattt 1954261 aagcgagggt aaaaatgatg gttttctatt gatgaacgaa gcagtttctc ctcctttctt 1954321 gtctattttt ctaatcaatt ctctatcggc gtgtcaaatc ccttcctctg cattcttatg 1954381 aaatggcaaa aagcctgttc tttcgataag aacaggcttt tacactatgc atttgctgat 1954441 tgagtttttt gttttacagc ttcaagaatg ctgtcggctg cttttttaga gccgcctgcc 1954501 gctttcagtg attgtccaat ttcttttgcc ttttcagcat acgaacgatt attcattact 1954561 tcttgtatcg tctctttcag taggctttca gacaattctt cctttttaat tacttttcct 1954621 gcgccgactt tttctacctg atctgcgaca acaaattggt cgcctcccat cggaatgaca 1954681 acgagcgggg tttcaaaata caaaccttca cttgtgctgt tcattccgcc gtgggtcaca 1954741 aataagctgg ctcttttcaa gatctcaagc tgagggacat acgggcgtac aatgaaattc 1954801 tccggaatgt cgtttaactc acttgtttta atatgcttgc cgatggaaag cacaacttta 1954861 ccgtcaaagt ccttacacac ttcaaggcat tgattaaaaa actgcttttg attattaaaa 1954921 atggttccca ttgaaataaa cagcacgttt tcattgtcaa tctgatcaaa tgggaaatca 1954981 ttgtttccgg ctctttctgt aatggaagga ccgacaaata catatcgctc gccaaattgc 1955041 tcagccagtg gctgaaatcc ccttgatgta aagacgattg tcaagtcacc atcagctaaa 1955101 aaaacatcaa atggcttctt gatctctgct tgaaaatcag catttaacgt ttctgcaagc 1955161 tgctggtatg attcataatg aggcgaatct tcaagtgatc ctttcatgta cgctcccatc 1955221 atttccttcg caaattcctc attcatcgca aaggttgtac acaatgaaaa tcttggcagc 1955281 ttcagcatgt tggcaatgac tttacccgcg agaagatggt gatcatatat gacataatca 1955341 tacgattcat gtttgacttc ctcataaata tgagtcgcga tatccttaca ggctttcaaa 1955401 aaagcgcaga gcatttctgt gaaatctctt tcttcatcgc cggttgcgtt tttcccgaag 1955461 taatctcctc tgaaatcatg atactcacga aactctatat caagagctgt gattttttct 1955521 ttatattcct tcactgcgta gtacgtaatg ttttctcccc gggatttcag ctccttcatc 1955581 acaccgatag agggattaat atgcccttca ccggggaaac cgatcattaa tacattagcc 1955641 atgcggcagc acccttcctt tgagaattta tgtaatattt tatacggtac tataaatgca 1955701 taaacaggta aagtatttca cttaattaat attcatcata tataactttt ctaccagttt 1955761 atattccctg tcttcaagac aaaaagcatt cagcttgaag cgaatgcttt aataaagatg 1955821 cgaattcagt cattttgtct catgatagga ttcttaatca ggcccttttt attattttta 1955881 cgttcttggt gaaattaacg gatataatac accgtctttg gcaaacgaca tcttccctgt 1955941 ttcctctgaa accacgagca ccagtgcatc cgtatagccc gacataccaa gagccgcccg 1956001 gtgccgggtt cccaaatgga tatccacttc cttcgtcgtc agcgggagca cattggctgc 1956061 tgacacgagt ttgttttccc tcactaataa agcgccgtca tgaagagggt ttccgggaaa 1956121 aaagatgctt tcaattaatg aagagctgat ctcggcgtgt agggaggtgc ctttttgaat 1956181 aaaacgttca accgggtctg ctctttcaat cacaattaaa gctccatgct tatgttccga 1956241 taaggcttta atcgccttgg ccagctcaat aaatgccggc gtaaattcct caatgtatga 1956301 ttgcaaataa aaggaggatg caatcccctg catgtcctga aaaacgtgcc ccaaatcatc 1956361 taattcacaa aggagacact ggtctttttc gtgaagcgtt ttcaagatta gagatgcatc 1956421 acctaatatt tgctctaagt acacctgtat tttccccttg aacgcatttt ctgatatctg 1956481 ctcatagcgc atagccttca tctcctgttt aaatttccaa cttttcacga atgcttatct 1956541 tattgatgca cattctattg gtaaaggagg gatgtaaaga atggaaatcg aaagaatcat 1956601 tcagtatatt tgcacctttt taggcgtgat ttcgctttct tttatttatg cccaaatgtt 1956661 tagaaaaacg aaaccgacaa aaaaagaata ggcccggcgt tcattgcttt ttatacataa 1956721 aatgttataa tttctctcgt tatgaaaaag aaacggagat caatgtatga aagaaactca 1956781 aaacgcccgg gaaaaaatca aacagctctt gcacatttta ataccgatat tcattaccca 1956841 agcggggctt tctctgatca cttttctaga tactgtgatg tcagggaaag tcagccccgc 1956901 tgatttagct ggtgtcgcca ttggctcaag cctttggacc cctgtttaca caggacttgc 1956961 aggtatatta atggcggtca ccccgattgt cgctcagtta ttaggtgcag agaaaaaaca 1957021 gaagattccc tttactgttt tacaagctgt atacgtggcc gcgcttctta gcatcgccgt 1957081 tttagtgatt ggatatgctg cagttgacct tattcttggc cgattgaacc ttgatattca 1957141 cgtgcatcag attgctaaac actttttagg ctttttatca ctgggaattt tccctttatt 1957201 tgtttacacc gtgttgagat cattcatcga ctcattagga aaaacgagag tcaccatgat 1957261 gattacactc agttctcttc caatcaattt tgtattgaat tatgtattta tcttcgggaa 1957321 gttcggaatg ccggcacttg gaggtgtagg cgcgggactg gcatccgcgt taacttactg 1957381 gtgtatatgc atcatcagtt ttttcattat tcataaaaac gcaccgtttt ctgaatacgg 1957441 gatttttctt accatgtata agttctcttg gaaagcatgc aaaaatttgc tcaaaatcgg 1957501 gctgcctatt gggttcgccg tgttttttga aacgagcatt ttcgcagctg tcacgcttct 1957561 catgagccat tttcatacag tgaccatcgc gtcccaccag gcagccatga attttgcgtc 1957621 tcttttatat atgctgccgc ttagcgtgtc catggctcta acaattgttg tcggatttga 1957681 agcgggtgca gcccgtttta aggatgcacg ctcatatagc ttaatcggca tcatgatggc 1957741 gatcggcttt tctttgttca ctgccgcctg tatcctttta ttcagagagc aaattgcggg 1957801 catgtacact tctgaccccg atgtgctccg gctgacacag cactttttaa tttatgcgct 1957861 attttttcag ctttccgatg ctgttgccgc accgatccag ggagcactca gagggtacaa 1957921 agatgtgaac tatacgcttg cggccgcttt tgtctcttac tgggtcattg gccttccggt 1957981 cggttatatg gtcggtacgt ttacaagcct cggtgcattc ggctattgga ttggattaat 1958041 agcgggactc gccgccggag cagttgggct gtttttcagg ctggcaaaac tgcaaaaacg 1958101 ttattcgcaa aaacaacaca tttaaaagag gtgatcaatc atggcaaaaa acaaaaaatt 1958161 attcgagtat ctttcccagc atgcggaaac catcagttca acatggtatg aaacaatcga 1958221 ggagactgat cccaattcca tttatgcctc aacagaccct gttgtcattc acaatttaaa 1958281 gagccagaat cttgccttta actataaaat aaaccgtatt tttatagatg atgaggacgt 1958341 atacttgcct atactgaaag aatgggcctt tgaagtcaca caggatcaag agcatttaaa 1958401 aactcctatc cactatatta ttcgggagtt tgtcagagtg agagatttat atgtttctta 1958461 tgtgaaagaa tttgtccatc tcaatcagaa tactgtgaaa agcgaagaag ccgaagacct 1958521 gtatcacgcc cttataaaag cgtttgatct tgtgattcat atttttatag aagaaatgta 1958581 caaaaacaca agccttcagc ttcaggccca aaaagatatg attactgaat tgagcgctcc 1958641 ggtcatcgtg ctgtttcaca gcgtcggact gctgccttta atcggagata ttgatacagt 1958701 ccgcgccaag ctgattatgg aaaacacact gcatcaatgt gcgaaaaaaa aggtgacaca 1958761 actgtatatt gatttgtcag gagtagctgt gattgatacg atggttgccc atcagctgtt 1958821 cagtctgatt gaggcgcttc gtttaatcgg tgtttcttca actttgtctg gaatccgtcc 1958881 ggaaatcgcg caaacagcgg ttcagctagg tttgtctttc gaaggtattt ccttgagatc 1958941 cactctcgct tcagctattg catcggactt aaaattaaaa aaggtataag gcttaaggcc 1959001 ttataccttt ttgattaatc attccattga tacgtccaat atatttcttc ttcaaaccat 1959061 gttgccataa caggttcatt atttttcaat ttctcttcaa gctctctgag catgccttct 1959121 gtttgtgtgc ggtgagctct taacgcattc attttaatat cagctacttc tttgatatca 1959181 agtacgacat cagcttcgcc gagaacctct tctctgttgc gggtaatggc catgcagatt 1959241 gtacgcggac ggtcttcttt ctttttgcgg tataatgcac ggataaccgc ttccccgcat 1959301 gcatcatggt cagggtgcac accgtgtccg ggataaaatg tgacaattaa acttggtttt 1959361 acatcatcta tgatctcttc catgatatca gctaaatact catcgtcttc aaattcgagc 1959421 gttttgtcac ggagtccaag catccgaagg tcattgatat ccatttcttt gcaagcgttg 1959481 atgagctctt gttttcttag cagcggcaac gtttcccgat tcgcgaaaaa tggatcgccc 1959541 atatttctgc ccatttcacc taaagtggcg caggcatacg taacgggaat gtcttttttt 1959601 ctgtttaagg caatgaggcc tgccactcca tatgattcat catcagggtg aggcaggatt 1959661 actagtacat gttctttcat tattattcac ccttttcttt aaactgtgaa cggtttttcg 1959721 ctgatttgca gagaaatagc cagtttaccg cccggcaggt gtcccgccat taataaacgg 1959781 ttttcttcat ctaccgtgta ttcagtcaag ccttcagcat aaatccagcc ttcttctgtt 1959841 ttcaagccaa cgcggtaagg cccgttgcct ttgatttttg cctgatgata agtgactttt 1959901 gcattgcgaa tatacgcaac aaccgtcatg ttcttttcat ttaagtgcgc tgaataagaa 1959961 cctgtggtgg tttctaaatg gatatataca gggcggtccg catatcgttc taaagatgct 1960021 tgcacatctt cttttatgat cgctttcatg attgctcccc tctttcttct tttaaatact 1960081 ctgcacgttc tgtatgtaat ttgaccagct gatatttcac agccggttcg agctgtgaat 1960141 tcacaatgcg ctgaatcgcg gcaaaatatt tttccagcat cggttttcgg agtcttggat 1960201 gtgttcgttt atccaagagc tcaagatcaa tcgcctctgc taccgcttct gcgtcatcat 1960261 gtgcgagaga tcggttattc caaagtgaag cataggcttt cactatctct ttatcattgt 1960321 ccatcgtctt gctcctttat gtcttacata catgaaatga ttatacataa tatatgcatc 1960381 agctgaaaag ccaaaggcct caatggcttt ttgacgcccg tttccacttc acttgtgaaa 1960441 acgtaaacaa gagcagcgca gcccatatac agctgaatgt aaaagccttc gagcttgaaa 1960501 atggctcatg gtaaacaaac agcccgatca gcagggtaat ggtcggcgca atatattgta 1960561 agataccgac ttgatacagt ggcagccgtt tcgctccttc cgcaaacaat aagagcggca 1960621 aagccgtaaa cacaccggcc aaaaagagaa gcagccacgt ccctccgctt tctgcacccg 1960681 ctggctgaac atgtccgctg aacagcaaat accccaatgc aatgggcata atcatgaatg 1960741 tttccagcgt taaaccgatg gcgctcggca ggcttgttct ttttttgctt aacccgtaca 1960801 gcccaaagct gaatgcgagc agaagcgcaa cataaggaat ggagccgtat tggaacgccg 1960861 agatgatgac accggctgcc gcaatcgaaa cggccactaa ttgcaggcga ttcagttttt 1960921 cctttaaaaa taaaatccca aggagcactg atacaagcgg attaatgtaa tagccaagac 1960981 tagcctcaag caaaaagcca tggttgacag cccatatgta tacaaaccag ttgatcgaaa 1961041 tcaggataga agcaagaaat aaagagagga tccctccgtt ctttttcaga gagcgcaact 1961101 cctgccatcc tattttccat tgccgcaaga aaaaaagtac gatacacata aaaacaaaag 1961161 accatataat acgatgagcc aaaatatcaa gagccggcag ctgttcgaga agcttccaat 1961221 agagcggaaa caggccccac atgataaatg aaacggctgt gtaaataacg cctttttttg 1961281 tttctgcatg ttgcattgat atccctgcct ttctttagag catcttatat tatatcacgt 1961341 gaaagatctg gtgggcatat actattttgt ccgtgaagaa aggatgtgaa gacaatgttt 1961401 gagtggaaca agtactttcc tttccacaat caattttcta aagaagcatt aaaaaaagct 1961461 gatccgaaag aagttgaaac gtatgtcaat cgtgtgatgg aaagtgtgtt cggcagtgat 1961521 tatgcggctc aatttccttt ccgcgatcct ctcccccaaa aagaacatcc cgccaaacct 1961581 gatgcaaaac ctgatgtcaa acctgatatt gatatattcg aaacagcaga ccatgtgttt 1961641 gtaaaggtgc caatcagcga agaatggctg gaacaagtga gaatcaaaca cacatctcac 1961701 gaattatggt tggaaaacct cccaagagca gatcatccga aaaaagtaaa ccttccttgt 1961761 ttagtcaaac gcaaaggaac aaaagccgtc tataaggatg gccttctgga agtcatgttt 1961821 caaaagcagc aagactacaa tatgtccgag gtagaaatca tccgataaaa aacggcctgc 1961881 aatcgatgca ggccgttttt tattaataga agccgggata tcccccgtat ggcacgccgg 1961941 caccaaaacc gtacggtccg cctccatatc cataagggcc aggaggatag gcatagggac 1962001 gagaatagtt aaacagcgca ctcccgagaa aaccgcctaa taaaccgccg actagaggag 1962061 cgccaaacaa aaaaggacta cgcgccggat atccggctgg acctgggatt ccgcgtaaat 1962121 acgaatgatg agggtacatg attttttcct cctttatgtc tgcctatacg taaagtattc 1962181 agcaaggaag aaaaacgatt gggctacgga ctgtctatga ttgttacatc acaagccctg 1962241 ccaataacac acagccgagc cctgtaaccg aaagaactgt tgtaagcagc gtccaggttt 1962301 gaaatgtttc tttcatgctc aagccgaaaa attcctttac catccaaaat cctgcatcat 1962361 ttacatgaca cgcaatgaca ctgccggctc ctgttgcaag caccattaac gcagggttta 1962421 cactgccagc ctccataagc ggagctgcca ttcccgctgt ggtaagcgca gccacggtag 1962481 cagagcctag acacagacgc agaaccgcgg cgatggtcca tgcaacgaat agcggcgaca 1962541 tgtttgtttg acggaaaaaa tcagcgacat aatcgccgac tccgccgtca atcagcacct 1962601 gtttaaacgc tcctccccct cctatgatga gcagcatcat cgcaatttgc gaaattgatt 1962661 ctgaaataga tctgccgatt tcctgcatag atattttacg ggcatatccc atcgtataga 1962721 gtgcaagcaa cagcgaaatg agcattgccg ttcccggagt gccgataaat tctataatgt 1962781 cttttccttt tgaatgttca ctcaataata aagaaaaaat tgttgccatt gccataaaga 1962841 taaccgggaa taaagacgtg acagcactga tcgcaaagcc cggtgtttca tccagctgaa 1962901 attctttcct tggtcctaac cccgataggt ttccatgctt ttgatacgca ccaggaaacc 1962961 gtttcatcgc aaatttatta aataaaggcc cggcaatcac agttgtcgga acagcgatga 1963021 tgattccaaa aagcagcacc tggccaatat gggcaccata tgcaactgag atagcagttg 1963081 gagcaggatg cgggggcaaa aatccgtgag taacatttaa ggcggcggcc atcgggattc 1963141 ccagatacag aaaaggcatt tttaattctt tagcaatcgc gtaaacaatc ggtatcaaca 1963201 gaacaagacc gacttcaaaa aatagggcaa tcccgatgat aaaagaggca accacaaccg 1963261 ccgcctgtat tcgtttcctc ccgaatttgt caatcagcgt aatggcgatc cggtagccgc 1963321 ccccagcatc tgagacaagc ctcccaagca tcgcgccaag tccaaacact aaagctaaat 1963381 gccccagctg cccgccaatt ccagtctcaa ttgaaagaac aattttattg atatccattc 1963441 caagtccgat ggctactaaa aatgaaacga caatcagtga gacaaaggta tttaatttta 1963501 ctttaataat gagaaataac agaatcagca ctccgacagc tacaattaaa atcggcatgg 1963561 tacccctcca aaagtgtttt atatgattct cgcgacaatg ttttggcgct tttcatgcct 1963621 agatgaacag aaagcgcttt cattaataac taaaaacgtc ttggttatat gattgttatc 1963681 ttttgatcaa ctaatatgtt catactaatc tcctaatcaa tgactgtcaa tcgtttttat 1963741 gagcttgtct cgattaccta ccgcctaacc caatgattta ttagttatat gttgattaac 1963801 ttttggttat atgttatgtt ttttaaagtt gactgccaat cattatatct ctccattgtc 1963861 tggaagcaaa tgagacaata tgagaacaga cggataacaa cttcataaga ggaggagtac 1963921 acatgccatt attgcgtttt gatgtaattg agggccgtga tgaaaaatcg ctgcaattgt 1963981 tattagatac tgctcaccaa gcgatggttg aagcatttgg tgttccggaa agagaccgtt 1964041 atcaaattgt ccatcagcat cccgcaaacg agcttataat ccaggatgcg ggattagggt 1964101 ttcagagaac caaggatatg gtcatcatta gcatgacaag caaagcaaga accgaaagcc 1964161 aaaaggaaaa attgtatgct ctgcttgctg aaaggctaga aaaaaaatgc gaaatttccc 1964221 ctgacgacct catggtatct attactgaga atggtgacgc agactggagt ttcggtctcg 1964281 gtgaggcgca atttttgaat ggaaaactat aagatttcgt ctccccacaa aaaaaagaag 1964341 agagagctcc aaagaagctc tctctttttt cataaatgcg gaagtcatca gtatagaagc 1964401 atccagcaat acgaaaaacc tggatctcct tttatatccg gtttaaatgc caattggaag 1964461 ctgactgggt tttggctgaa aatataaaat tttgctgatt tgcataataa gatacatcat 1964521 aatccccatt tacaataggt tggatgttat agcttattga tcatttccta ttttatatat 1964581 ccccttcata tgcacatgac atttttgcca atccggaaat atcagtctga caaatataaa 1964641 aagtcatgta aacgggtgtg aaccgtactt acatgactca ccatggaaac aaaggctctt 1964701 tttcaggtgc cgctttcctt atttctcttc ttcacacact gtgtcaccag gctcgcaaaa 1964761 ttgatcggcc catgcctgca tttcttgaaa tacagcttga agcgctgttc ctttttcagt 1964821 cagcgtgtag atgactttga ccggcgtttc agggagaacc tgccgttcga caatctcgtt 1964881 ttgttcaagc tccttcaagc gctctgccaa cattttttgg ctgatcatcg gtattgtttc 1964941 cgttatctct ttaaaccgtt tcggcccatc cattagcaca tggatgatca gaccgttcca 1965001 tcgttttccc agcaatgaga atgcggattc cattttaggg cacatcgtat ttcccataag 1965061 tcttcatccc ttcatctatt gattgacatg tattcaatga tccattacaa taatctttca 1965121 agttacattt agtaagcttc taacttttct attatcatac cacgtttatc cgaaggagga 1965181 aacactatga cgaatactct ggatgtttta aaagcacgtg catctgtaaa ggaatatgat 1965241 acaaatgccc cgatctctaa ggaggagctg actgagctat tagaccttgc cactaaagcg 1965301 ccttctgctt ggaaccttca gcattggcat tttacagtat tccacagcga tgaatcaaaa 1965361 gcggagcttc ttcctgtagc gtataatcaa aaacaaatcg ttgagtcttc tgctgttgtt 1965421 gccattttag gcgatttaaa ggcaaatgaa aacggtgaag aagtttatgc tgaattagca 1965481 agccaaggct atattacgga tgaaatcaaa caaacattgc tcggccaaat caacggtgct 1965541 taccaaagcg agcaattcgc acgtgattcc gctttcttaa atgcttcttt agctgctatg 1965601 cagcttatga ttgccgcaaa agcaaaaggt tatgacactt gcgcaatcgg cggatttaac 1965661 aaagagcagt tccaaaagca atttgatatc agtgagcgct atgttccggt tatgcttatt 1965721 tcaatcggca aagcagtgaa gcctgcgcat caaagcaacc gtctgccgct ttcaaaagta 1965781 tcaacttggc tgtaaggata tgaaaaacct tagtccgaaa tccggactaa ggttttttta 1965841 tacaatcgcc tctttgtacc attcacgagc ctgttcagct tcatgctgag tcagctgatg 1965901 gcccccgtcc tgccagtaaa cggaggctga tgccccgctg tcacgcaaat agcggtaaag 1965961 ctcttctgat tcttccttcg tgcaaagagg atcgtatttc ccggcaccga taaaaacagg 1966021 gagccccgcc atatcaggca gctcgatacc ccgaatcgga accattggat gatgcagaat 1966081 agcccctttt aacacatctt tataatgaaa aagcaggctt gccgcaatgt ttgcgccgtt 1966141 tgaataaccg actgcaatca ctcggccgcg attaaactga tgcgtttctg cagcctcgtc 1966201 gataaaatct ttcaattctc ttgtccgcac cacaagatcc ttttcatcaa aaactccttc 1966261 actcagacgt ttgaaaaatc gcggcattcc attttcaagc accgatcctc tgacaccaag 1966321 caaatgggca tcagggtcta taaaccgccc caatgaaagc agatcgtgtt cattaccacc 1966381 cgtgccatgc aacagcaaaa gtacgttgtc agatgttcct ttctcataaa tatgcttcat 1966441 tataaattcc cccttttaaa gttcaggtaa aatgtctgta atttgttgtc tatgtttctc 1966501 cagccattca ggcagtttta aggaagtccc tagctcagca aacgtttcat ctgtcataaa 1966561 gcccggttca tctgtggcaa tttcaaataa gataccgcct ttctccctaa aataaactga 1966621 tgtaaagtat tccctgtcga gaatttctga cgaaggcaga tggttttcag caataatcgg 1966681 cagccatttc gcctgttcct ttttcttagt ccgaaacgct acatggtgta ccgtaccata 1966741 tcctccgact cctctttttt caggatgtaa atggacatca atgacaccgc cgaccgccgc 1966801 tgaagatgcc agtctgacaa tctggtcttc ttcggccact ttggtgtatc caaagctttc 1966861 cgttaacaat tgtatggtcg cctgcgggtc gtaggaatat agcagcacac ctttcattcc 1966921 cgtaattgct tcatttgttg tgatcccgtc aggcgtccac tcgcttttgc cgcttttcgc 1966981 atcctccatg atcgccagcg gaaggtcttc tgtatcatca aaaataagac ctttttcacc 1967041 aaacaacgtt ttttcctcta ggctcagccc gcttttctca agacgttcct tccaaaaaga 1967101 cagggagcct gagggaactg aaaagtacac ccggcccgct tggccttttc ctaccgttcc 1967161 ctgtccgctt ccttggaacg gaaaaaaggt cattattgta ccgggatctc cgttttgatt 1967221 cccaaagtaa aaatgatacg ttccgggatc atcaaagttt actgtttttt taacgagcct 1967281 gagcccaagc acttctgtat aaaatcgcaa gttttcttgc ggatctctgg cgaatgctgt 1967341 gacatggtgc aatccttctg ttttcatttt ctcactccta tttatctcga tttcaagata 1967401 tttattattt taaaccttta ttgaaaagga tgcaaaccat gtgttttgat taaataattg 1967461 aaaaaatcat ttttttctaa taattatctt gtgatctttt cttacaactg ctattatagt 1967521 gagcattatc atgtttcagg aggaaagtaa atggttaaaa aagcacttat tgttattctc 1967581 attcttttgc cattcgttca gctcgcgctt ttgccgcttg tgaatcgaat agaaccgatt 1967641 atgttcggcc tgccgttttt ccacttttgg ctgctgctgt ggattattgt tacgccgtta 1967701 tgctcgtttg gcatttatca gatgcaaaaa aaagatggag gacttgaata atgcaaggga 1967761 atctgactgc acttctcatt actgctatta ttgttttaac cgttgtctgt atcggctttc 1967821 tcgccggaag agacaaatcc tcacgtactt ctgtggaaga atggtctgtc ggcggcagac 1967881 gcttcggcgg tcttctcgtc tggtttttag taggcgctga cctttatacg gcctatactt 1967941 tcttagggtt gaccagtact gcttttacag gcggaagtgt tgcatttttc gccattcctt 1968001 attctgtgtt ggcctacttt atcgcctact tcttcttgcc aaaactttgg aaagttgcga 1968061 aaattcataa attaacaaca ctcgcggatt atgcccggga acgttttaac agtaagcttt 1968121 tggcaagcct cgttgccatc gttggggtac tcatgcttat tccgtacata tgccttcagc 1968181 tgagcggcat tcaagacacg cttcaggttg ccggcactgg ctatattaac gtaaaattcg 1968241 ttgtgatcat ttcatttatt cttgttgctc tttacacatt cttcagcggg attaaagggc 1968301 ccacatatac agccatcatt aaggacattt tagtatgggt cattatgctg tttatggtgg 1968361 tgtccctccc tctcattcat tttaacggct ggacgccaat gattgacacg ttagtgaagg 1968421 aagcgccgca aatgctgacg ataccgtcag aagggccaaa aggcattcct tggtttatca 1968481 cagcatctat tgtttccgct ctggcacttt ttatgtgggc acatgccgct acaggtgttt 1968541 tcacggcgaa aagcgctgat gcagtaagaa aaaacagcat gtttttgccg ctttataata 1968601 tcgtgttaat tttggttatt tttcttggct ttatcgcctt tcttgttctg ccggaagata 1968661 caaatccaag gctggcgctg ctgcatttga ttcaaacatc ttacggcggc gtggcacaag 1968721 gctttgcata tgccactatc gctcttgctt cattaatacc ttgttccatt atggcaatcg 1968781 gcgcatcgaa tttattcgcc aacaacctat accgggattt gattcatccg aatgtgtcgc 1968841 aaagcaagct gactcttgtc acacgttcaa tggtgtttgt tgtcatcggt cttgcgctgc 1968901 tgtttggaat gctgttcccg actgccttag tgacacttca gctattaggt gtatccggta 1968961 tggtgcaaat cttccctgcg attgctgtca gcctgttctg gaaaaaccaa acgaaagaag 1969021 caacggttat cggattatta gccggcctag cggtaacgtt tattgtgtat atcactcaat 1969081 ccgcacatgg catttatgaa ggattctggg gattggccgc caacatgatc gctgtggtca 1969141 tcctgaatcc gctgttcgtt aaaaacgcgg gatccaatcc tgtcattgaa ggtttatttg 1969201 gcaaaaaaca agacgctaat ccaaatcaaa agggcgcata aaaaaaccat acgcggcagc 1969261 cgcgtatggt tttttttaca tttctttttt cagtgtttca attgcctttt ccatttgcgt 1969321 atcattatca gacagcttct tttgaagttc tatcattaat ttcgttgttg tatcgccagt 1969381 cagtatgcct gtttcattca gcttctcttt tttctggaac tgtttgacga cagatacaaa 1969441 atcctggtca tacatactgt taacctttac cttgtaacca agtgctttga gcattttctg 1969501 agccactttg acgtttgtgc ctgtatcacc tgatttgtac gttttatctg cgtccaaata 1969561 cggcagcttc gcgtaatcag gcagctctgc tttcacttga ggcttgatgc cttttttgtg 1969621 aatccattcg ccatcagcag tcagccattt ggcaactgtc agtttgacgg tagagccatc 1969681 atcatattct tttgccgttt gtactgtacc tttgccgaat gtcgtctcgc cgattaacgg 1969741 tacgtttgac gattcatgaa gggcagcggc cataatttcg gctgcgcttg ctgtaccgtc 1969801 atttactaaa acgacggtcg gcttggtcac tttccgttct ttttcggcct tcatgacttc 1969861 ttttgaaccg tttttgtatt caacctgcat gatgtttttc cctttatcaa tgaacaggtt 1969921 gctcatcgta atcgcctgtt ccattaagcc gcccgggttg cctctcaagt ctaaaatata 1969981 gcctttggcg ccttttttct ctaaactgtc aatcgcatct gtcagctctt tagctgttgt 1970041 ttcagagaaa gaagtgattt gaatttctcc gatgttgttg tctttcatct ctgaatagac 1970101 agtctctaca ggaatggtat cgcgcttaat ggaaagatcg atattcccca ctcccgctct 1970161 gttcagttca agcttcacct ttgtgccctt tttgcctcgg attaaagcga cggcttcatt 1970221 tacattcatg ccttttacgc tttttccatt taccttaatg atttggtccc tcggtttgat 1970281 accggctttt tcagcaggtg aacctttaat tggggataca ataaggattt ctccgtcttt 1970341 ctcctctact tgggctccga ttccttcaaa agatgctgaa atcgtctcgt cgaatgattt 1970401 cgcttgctct tgatccatat atgtagaata cggatcatcc agtgattgaa tcattccttt 1970461 aattgctccg tctactaatt tgtcatcatc tgttttttgg taataatcac ttttgatttg 1970521 ctcatacgct ttatttaatt tgtcgaactt gctgtctcct gtgcttgctg atttttggcc 1970581 caggatactg gaattgcccg taataaataa agtaagcgcc gaagcgacaa ctgcagtgat 1970641 cagcacaata aaaaacagtt ttaattgccg tttcaattaa acaccacctt tttcttctta 1970701 cattattatc atggacgaat tcttattcgt caactcggag cagaaatgaa agagaaacgc 1970761 ccttcttttg cttttcataa acctatgtct ttatacgaca tatgataagg aaaaaggagg 1970821 attcgatatt gagccgatat ttagaaatgc tgtccttatt cggtgtcgca ggggcgcacc 1970881 caggcgggct ggctttttca aaagcggtct tgcaaaaggc tgcaccctct ccggatcagc 1970941 cgattcttga tgccggatgc ggaacagggc aaacggcggc ttatttagga catttgctgt 1971001 atcctgtaac agtcgttgat aaagatccta ttatgcttga gaaagcgaaa aaaagatttg 1971061 cgaatgaagg gcttgccatc cctgcatatc aggcggagct ggaacatctc ccgttttctt 1971121 ctgagtcctt ttcctgcgtc ctgtcagaat cggtcctcag tttttcacgc ctgacatcct 1971181 ctcttcaaga aatttcaaga gttttaaaac ccagcgggat gctgattggt atcgaagctg 1971241 ctttaaaaaa accaatgccc cctgcagaaa agaagcaaat gatggatttt tacggattta 1971301 cttgcttaca tgaagaaagc gaatggcata aactcctaag atcctatggc tttcaaaaaa 1971361 cagaagcgat gtcacttctt ccggaagaca tggaatttga accaaccaca gaaatggatt 1971421 tatcgcaaac gattgatccc atctattacg atacgcttca aacacattat cagctcatgc 1971481 agttatatag tgagtacatg ggtcattgta tttttatcgc gtacaagtaa aacggcgtat 1971541 cgccccctgt tttcgtccaa cctttttttc ctatctatca tatgctgata gaaagtcagg 1971601 ataggagggg aacaatattg gagagatatt atcatctttg caaaaaccat caaggtaaag 1971661 tcgtcagaat tacagagaga ggcgggagag ttcacgtcgg cagaattacc cgtgtaacaa 1971721 gagacagagt ttttatagct ccggtcggcg gagggccaag aggtttcggt tacggatatt 1971781 ggggcggtta ttggggatat ggagcggctt acgggatttc cctcggttta attgcaggag 1971841 tggctctggc tggtttattc ttctggtaag catagaacaa atgctagatt caccagacac 1971901 aatgaagccc gcttatctag tgtaagcggg cttttcattt taaattttct tcactttttc 1971961 aaagtactct tcaagcgtta aatcattatc ttggatgacc tttgcggctt ttttgcctac 1972021 atagcgcaga tgccatggct catattcata tttcgtgata tcttctttat ttttcggata 1972081 gcgaataata aagccatatt tataagcatt gtcctgcacc catttcccgt ctgccgtgct 1972141 tccgaacgct tcatttagct caaagccatt gctccggctc gaaatgtcca tcgcaaggcc 1972201 tgtttgatgc tcgctttcac ccgggtaagc gaccgcttcc tttgccttcc tttccccttt 1972261 taggcttact tcattgtcaa aaatgacttt ctgtctgtca tacgaacggt accctgagac 1972321 agctgccagt tcatagcctt cctttttggc agcatcgaac attgttttta atgcgtcggc 1972381 cgcttctttt ctgatgtaac gtttttgaat cttttcttca aaagaaaact ctacatcagg 1972441 tatgacaaga tcgctaggtt catagtttcc gggcagtgca tattgtttat tgacaagcgc 1972501 gagtatattt tctggatttt gaatggtttc cagaccatcg acttttttaa tatcattgaa 1972561 atactggctt tccaatgaaa actcactgtt ttgagtgttt gattttttgc tgtcagctgt 1972621 tttttgttct gtttgctttg tttctgctgt ggttttcgta tccttttgag catctccgtt 1972681 cgacatgctg cagccggctc cgactattgc cgttacactc agagcggcag ccagtgagaa 1972741 ccatttaccg gactttttca tattacatta ccttcctttt atcaatcgtt tccgcatgca 1972801 taaagaagag gctgccggca cccagcacgc ctcttgatat attttattgt gatacggaat 1972861 gtaaagccac ttctatcata tcatgaaatg tcgtttgacg ctcttccgct gtcgtttctt 1972921 ctcctgttaa tacgtgatca ctcacggtga gaattgacag ggcttttctt ccgtgcttcg 1972981 ctgctaatgt atacaatgca gttgtttcca tttcaacgcc aagcacaccg tattttgcaa 1973041 gtttttcaat ttgcgaatcg tcattgtaga actggtcagc tgtaaatacg cttcctacag 1973101 tcaccggcac acctttatcc tttgcggcat cataggcatt ttttaaaagc tcgaaatctg 1973161 cgcaaggcgc aaaatcaacg cttccgaaag caactctgtt catttgtgaa tcagttgagg 1973221 aggtcatcgc caaaatgacg tctcgcactt tgacatcttt acgaatagcg ccgcaggaac 1973281 cgactcttat tagattttgc acatcgtagc tttgaattaa ttcattcaca taaattgaaa 1973341 tagacggaac tcccattccc gtgccttgta ctgagatttt tttaccttta tatgtacccg 1973401 taaatccata catgcctctg acttcattgt agcattctac attttcaaga tacgtttctg 1973461 caataaattt tgctctgaga ggatctcccg gcaaaagcac agtatccgca atttgtcctt 1973521 tttcagcacc tatatgtaca ctcatctcat atcctcctgt aaatctaaat tatcatccag 1973581 cccgtccatt ttacaacgaa tgtcatgatg aaacaaactt cagcattgat tataaaggaa 1973641 tatatcgaaa aaagaaatgt tcgaggatct gttaggcact tcctcagaaa aacggataat 1973701 cggggtgtta atttgaaaac ctaaccgcag gaaggagggg tgggacatgg gtaaaaaaca 1973761 tcgtaaccgg atcaccggcc aaaaaaagaa caatcatata cctgaaaaag atatcattgc 1973821 agctgaagaa gcacacggga aagaatattc cgctgccaaa cgcaagcctt aaaactgcag 1973881 aaaactgcgg gtttccgcag ttttcttttc attatgtcgt ttgtacaatc agacgattga 1973941 ttttcctcca gccggcggga agcagttgat aatatgtttt cccttttctg ccttcatcaa 1974001 tcaggatcac gtcccctgtg gccatgaatc ttgcatcata atcactcgga acagtgtcga 1974061 atacattaaa caaagagaat gctcttttca gcacgtcttg atgatcgctc ccgttcagtt 1974121 cagttcgata gacggctctg tagccctttt tttcgccaaa ccggggtgtc tgaaatattg 1974181 tcacgtcata ggaacaagac ttctttttaa acacggataa catcatcaag atcccctccc 1974241 ttttatttct ttaacatatt ggcgtttttg ctgtgttttc ctctctctat ttttgtcgaa 1974301 accgcttaat cttttcgtca aaacctttta ctaggaaaaa cagaagcaag ccgaggctaa 1974361 agcctcctaa cacgtctgtc acaaaatgaa cccccagata cactctgctt atgccgacta 1974421 aaacagcaat tacaccggct atgatatata ccattttttt atgcttagac aaaaacggga 1974481 gatgtttcac taaaaagtaa gcaataacag gatagacaca agcagcattc atggaatggc 1974541 cgctcggaaa actgaaggat gattcatgaa ccagcggtgc aaaatcaggc ctcactcttt 1974601 cgatccattc ttttaagact ttgtttaaca gccgatctgt gccgaatact aagagcatca 1974661 acaggccgtc ccatgttttt ctgtagaaaa acatgcctgc tccaatgatg acaattagag 1974721 ggagcagaaa agaagaagca ccaagatgcg tgatccccgt catgacttca ttaagccatg 1974781 gctgacggat caaaacagct gccttgctta ttgcttcatc tgcagattga acagcatttg 1974841 tatgaatggc cgcagctaga attaaaaaga aaagaaacaa actaacgggc ttgtacaatt 1974901 ttaaccacct caattttcac agaagtcata gaacatgaat aataaaaccg gagctgaccg 1974961 ctccggtttt aagcctcact catcttcatc cagctcttca tctatcatac atttttctat 1975021 caaataatca aaggtaatat cagcgatttc aaacagctca tcctcactcg gtatgtagcc 1975081 ccgtcttgca agctctctgt aaaaaaattc agcgatttct tccgtatcaa tcacaagatc 1975141 tatttctttc atctccgtac cgcctccttt tttatgtttt atgaaaaaac aggctgaatt 1975201 atacccggtg ttctaaacaa ttctttcagt catatattga ataaaaaacg agccatggga 1975261 ggctgacgct atgattgcta aaatgatgga agcactggac ggagaaagat ttgatatcat 1975321 aatggaaaaa acgctcaaag gaatgacgcg tgtgatgatt tggggctgtc tgccatattt 1975381 tttatatgtc ttgatccgta tgttcacaaa ttaactgaaa tgctctttta aactttccaa 1975441 aacaaacatc atcatgtctt tatattcttc atcctgaaac atttcgtaca gaattttgta 1975501 gtcattataa atatccagaa gctcatcaac aattgacaca gcaaggatgt gaagggtatc 1975561 ttgatcttca tcaccgcctt caaactgaag aagagcagac gatgcgatat cttcgccgat 1975621 ctcatggcca gtttctccga cataatggac aaacaacagc tgatgcacaa actggtccat 1975681 ttcatatttt ctaagcacca gcgtgagatc ctcttcctcc gtttcaagcc actctccatc 1975741 ctttaaacgg gtcagctcat aaatgatatc ttcccagcca tcttctaaat atctccaaat 1975801 ttctgttcta tggccgataa tgcgaaagag ttcttttcca taatctttaa cataaacaac 1975861 gtccccaata aggaattcat actcaatatc aagcttctcc atgtcgacaa tgacaccctc 1975921 ataatcttta taaagctgaa tagatgattc aaagtataaa acttcgttat gattgacttc 1975981 ataaagatag tgtttatcaa tttggtgtac ttttgtgatg gtgccgactg ttccatacat 1976041 aatgacgact acgatatccc ctacttggaa tttcggttta ttttgcttca tggtgtctcc 1976101 ccctcgccgc aacatttctc atacgctatc gtatgccggg tgaagccaat tcgcatgggc 1976161 atgaaaacca aaggaaatat ccaattatgg tatgggtatg gacataaaaa aatccgcagt 1976221 gatctgcgga tgaaacagct attatctgcc gtgcacttca gactcgtatt gatcccaagc 1976281 ttcatcaaac gtcgccatcg tgtgaaggta atcagcattc agctccaaat atgaactgat 1976341 ttcatgataa tcggttgatg tttttggaaa gctgtgatcc tcatacgcct gattggcaaa 1976401 ttcactgatg ctgtccttcg gcttagggtg tctgtatttc aataaatagt gataaaagga 1976461 tttcatgggt ttcccctcct gatgtctgtc ttttgttgtt ctattataca gttcaagtgt 1976521 aaaattacaa caaaagaata ctgaaacatg actcaggaga agtcaaaata gttgcgtttc 1976581 aaaattcttt ctgtctccat gagctgctga tatgtcaggc tttcaggcag tttttttgtt 1976641 tgaattaaaa gcagctgatc ctcaatctct ttaaccgtgt tttcctcttg ataggtcata 1976701 ccgcaggaag aacataccat ggcaggggtg tctgtcagtt ctatagccct cgttccatca 1976761 gggagctccc agtacaccgt gttcctgccg ggcaccgctt cgagctcgcc gcaccattcg 1976821 catgttttca tgaagaatcc cctccgcatt cagtctcttt ctgttttttc tgctgcgcca 1976881 aaaatttctt ttctttgagc tgatctcttt tctcacgccg atcttttaat gtttcatgct 1976941 ccggatttgc gatgtatgcc tctctccttt tgattctgtc tacattttca ggtgtaaacg 1977001 aaacttcttt gtcagcaaaa atggcactca gcccgatcgg ctcctttttg tcagcggttt 1977061 cagggaaaac ggactcaaaa taggcgtctg cctgattggg gatataattc tctggttccg 1977121 gatatgacgt aatcacacct tcaaaatttc ttaagatcac tttgtcagga ctttgtgaca 1977181 ggacatagtt tggctgcagg gcgattttac ctcctccgcc tggtgcgtca acgacaaagg 1977241 taggaaccgc atagcctgag gtatgacctc tcagcccttc aatgatctcc aaacctttgg 1977301 aaacaggagc tctgaaatgc cctattcctt ctgacagatc acattggtaa atataataag 1977361 gacggactct gatttttacc aagtcatgca tgagcttttt cataattgga accgaatcat 1977421 taatacctgc taatacgaca gcctgatttc cgaccggcac tcccgcgttc accagctttt 1977481 cacatgcctc aacggattct tctgtcattt cgatgcttgt gttaaaatgg gtgttcagcc 1977541 agaccggatg atattttttc aatatctcgc acagatgatc ggtaatgcgc tgcggaaaga 1977601 cgacgggagc tcttgttccg attctgatga cttccagatg cggaatgctg cgcagctctt 1977661 ttaaaatata ttctaaaatt tggtcgttga tgagcagccc atcaccgcct gaaattaaac 1977721 aatcgcggat ttcgggtgtt tcccggatat aagcaattgc agcatcaagc tgttttttgg 1977781 ggacgcccat tccgatttgt ccggaaaagc gccttcttgt gcagtagcgg cagtacatgg 1977841 aacattgatt cgtgacaaga aacagcacac ggtcgggata gcggtgtgtc agaccgggta 1977901 ccggtgaatc ttcatcctca tgaagcgggt cttccagatc gtattttgtt ttgtgcattt 1977961 cttcagaaag cggcacagac tgcatgcgta ccgggcatct cggattgtcg gggtccatta 1978021 aagaagcata gtaaggtgta atatttaagg ggatcgtttt ggtagaaatt ctgacgcctt 1978081 cctcttcatc ctcggtcaga ttaatgactt tctttaaatc atctaacgtt cttacagtgt 1978141 gtgtcagctg ccaaagccaa tcgttccatt tctcttccgg aacgtccttc cataactcga 1978201 tctccttcca atgccgtttc ggtttatacc atttgttttt caaacgaact cctcctcgcg 1978261 catattttga cttacagttg cttgcaccaa atattcatgt tttcaaggcc ttcggctata 1978321 aagcaattat tgatcagcct tccgccatac tgataacctg aatggtacaa cacagcattc 1978381 atcccaaaag acgaagcacg ggcgagagaa aacacatgaa cgatatcctc tccagccatt 1978441 tctttttcta acgcctcgat taaaaagctt gttaacgaat ggccgcgata ttccggcagc 1978501 acagcgcaat cggttatttc tgcatgccca agctctggat tgatttctgc gcttgctgcg 1978561 ctgatcaggc ggtcatgatc aagcatgata taatacaccg tatttgcatt catcgtcttt 1978621 tcaatataag cggggtcaaa taccggggtt gggtacgtgc ggaatacttt tttatacagc 1978681 atcgatagct ggtacatgtc gtttgtttct gcttttctca tcgtaaaaac gggtgtactg 1978741 tcgttgcgaa gacggggcgc tgtgcgatat atggcttcga tgatctcctg ttcctctgta 1978801 taagaatctg tttgtctccg gctttctgaa aggtaacgta ccatgacaca agccgaatgg 1978861 ccgagataat agccctttag atagccctcc ggcgcaaata attgtttggc aaggatcggc 1978921 tcatcatgct gcttcgcata gacaatgatt ttttctgcat tctcttcttt tgccgctgcc 1978981 acgatatccg gcagggcctt ctcaatggct ccgtcataac gaaccactct gattcgttta 1979041 ttaaagccgt catggtccaa aactgctgtg acaccgctac tctttattga cttgagcatc 1979101 cgcatcctcc ccatctgtat gaaggccgca ccaatccatg acaaaaagtg caataatttt 1979161 agcagattct atcatggctt caacctcaat gtattcattg gcctgatgag ccgtttttgt 1979221 ttcccccggc ccgaaaacga tcactggtgt atctcctgca tggtacaaaa gccctccatc 1979281 cgttccccac ggggaagcct caataatcgg ctctgtctgt ttcatttttt gataggctga 1979341 ttgcagcaca gaaattaaag ggtgatcatc aggtaaatca ttcggcagcc attgagcgcc 1979401 aaaccattcg acttgtacgg gatggcgttt aaaccattcg tcatggtatt ctaaatcctt 1979461 cagccagttt tccaattcaa gttttacagc ttctggtttc tcatggggag caattccgca 1979521 tctcccttct atgacgacac ggtctgcaac tgaagatggc caggcaccgc ctgagatggt 1979581 gccgatattc accggtaccg gtattgggat attgtcatac agcggatctg aaattctcgc 1979641 attgcggact ttctccagct cttgtatcgc tgtgataacg tgcatgcttt tttcaatcgc 1979701 gcttacccct tcatagcgtg tgcccccatg tgcggataat cccttcacag tgatccgaaa 1979761 ccacatcgaa ccctgctgct taataaatag tttcatattc gtcggttcag gaatcagcgc 1979821 cccgtcagca cgatagcctc tcatgatggc ggaaagtgta ccggcgccgc cgcactcttc 1979881 atctacaaca ctctgaaaca atacatctcc cttcagtttg acatcgcagg cgtgcagggc 1979941 ttctaaagca aaaagaaggg ctgtattgcc tcccttcata tccgttgagc cgcggccgta 1980001 tattttaccg ttttcttcga cagcttgata cggttcatac ttccaatcct ttacgcttcc 1980061 ttcaggcaca acatcgatat ggccgttcaa aatcagggac ctgcctccgc cggctcccgt 1980121 ttttttagcc acgatattcg ggctctcatg aaaatcggat cggttagatt taaagtaggg 1980181 atgctgtttt aattgcttta tgcttggctc ccatacatca atgtccatat gaaattgccg 1980241 cagcttttca agcacaacag cttgggcgtt aaactctgac cccaatgtgc ttttttcccc 1980301 aatcagcctt ttgagaagac gaatggcttt ggccgaatgc tgatcaagcc actcgattac 1980361 ttttctttca atgtcttgca tcctcattcc ccctcttaag aaaaaggcat atctattttg 1980421 atttcagctt ctgtcagcct cgtcacctca tcgattgtcg agccattcat cagctctttt 1980481 aaaatgaagt gatggctatc gacctcaaga accgcttttt cggtaataat caaatctaca 1980541 cagcctgcag cagttaatgg cagcgtacat ctttctgtta atttaggcct tcccttttga 1980601 tctgtatgac tcatgacgac aaccactttt ttcgcttttt gggcaagctc catcgccccg 1980661 cccataccag gcaccttttt tcccggaaca agccaatttg ccaaatctcc tgattggctc 1980721 acctgcaggg cgcctaaaat cgtaatgtca attttgcctt ttctgatcat cgcaaaagac 1980781 atggttgtat caaaataaga agcccctttt acagcgcgga caggatatcc cgcggcgttg 1980841 cataaatgcg catcctcttc tcccttttcg ggactttctc caatgccaag gacaccgttt 1980901 tccgcttgaa acatgacctg catgtcaggc ttcaaaaagt tcggtaccaa ggaagggata 1980961 ccgataccga gattcacaat catgccctgc ttaatttcag tagcagcgcg ttttgcaatc 1981021 tgttctcttt ctgctactcc caagcccatt tccacttcac tccctcgctt cgtacaaccc 1981081 cctcaacaaa aacccccggt gtgacaatca tttcttcaga aatctccccc atcggaacga 1981141 tacgctcagc ttcggcaaag gttctcctgg cggccattgc cataagcggg ttcatattgc 1981201 gcgcggtttt gtcatacgtt agattgccga attcatctgc aatgtaagca ttgatgaaag 1981261 caaaatcagc agtcagcgcc tcttcaatca agtatcgttt tcccgccact gttacgatgt 1981321 cctttttttc gcaaaccatt tgattatcaa tgcccacgtc ggttaaaata ccgccaagcc 1981381 ccgctccgcc ggcgcgaatc cgttccgcaa gcgttccctg aggtgaaaat tgaacctcta 1981441 acgtcccctc tgtcatctgt tttccggcta ctggattgga accgatatgc gaggcgatca 1981501 gggttttgac ccgttgatta acaataagcg ggccgattcc gatatccggg aaaccggcgt 1981561 cattgcaaat cacagtcaaa tccgttacac cgctgtccaa tatcgcttca atcaatgaag 1981621 gaggcgaccc gactccccca aaaccgccaa acatcagaac cgatccatcc cgaacatctg 1981681 caattgctgt gtcaatgctg attgcttttt gaaatggcgc catttaatgt caatcctttt 1981741 ttaagttttt ttcgaccgct gcaactgttt ctgaaaaaat agagataagc tcttccattt 1981801 caccgtctga aatagtaaaa ggaggagcaa taatgacagc atctccttct ccactgtcta 1981861 ttccagcttt ggaaggataa acaatcagcc cgcgtttttt cgcctcgctg acaataagct 1981921 gggttatcgc ctgctctggc ggaaacactt tcttcgtttt ttggtctgcc acaaattcaa 1981981 tgcctaatag cagtcctttt ccgcgcacct cacctataat gccgctttga gatgccgcct 1982041 catcaagctt cttcttcagc acagcgccct ttttttctga ttgtttgatc aagccgtgct 1982101 ttaacacata tcgcaaaact tcaagagcag ctttggctga atagggatgt gcactatatg 1982161 tgtgaccgct cataatcaca cctgaccctt gttttatggt ttcaataata gaatcagata 1982221 cgacggcagc agcaataggt gcataccccg caccgagtcc cttccccagt acagcaatat 1982281 caggtacggt atcccaatgc tctgtcgcga gcatccttcc tgttctccca agccccgtca 1982341 tcacttcatc tgcaataaaa agcacatcgt gtgtgcggca tacctcactt aatctctcat 1982401 aatatcccgg aggcggagta atcgctgctc ctgcagcacc aataataggc tcagccacaa 1982461 agccggcgat gaattggctt ccgattcttt taatcatggt gtccagttca tcagctgcag 1982521 tctgaacaaa gtcttcttcc gtctcgtgat tcagccgata aatatgtgga gctgagatag 1982581 ctggataccg ctcaatgaga tgggtgaacc ggtatctcct ttcataaaaa ccagacaatg 1982641 aaagcgctcc caaagttatt ccgtggtaac tgctccatcg agacaaaaag atggattttt 1982701 gtgtttgctt tttttcctgc caatactgaa tggcgatttt catagctgtt tctatcgctt 1982761 ctgatccgct gttgacaaaa aaagaccaat tcacatctcc gggcagctcc tgtgccaaga 1982821 gagcggctaa ttgctcggcg ggctcactcg taaactgtga gcggtaagca aaagacacct 1982881 gatcaagctg ttctttcagc ttctcagtca catcacgaac tccgtggccg atattacatg 1982941 tcaccgcacc tgacgagccg tcgagatatt tttttccggt ctgatcataa acatatgaac 1983001 ccttcgcata actgacaacc ggataggccg agctaagctc tggcttaatc aaataactgc 1983061 tcatgctccc acctcaaaac cccttttacc atattgtatg agtgtccaaa tggcggcatg 1983121 acgttccccg caaaaacttt ttcacataaa aagagccttc ctaataagga aggctctttt 1983181 gaaatttcag catctagcaa ataaaagcgg ctccaacaat aattaataaa atgaacaaga 1983241 caacaattaa cacaaatgta tttgtcccgc agccaaatcc gtaaccgtac ccagagtatc 1983301 catacatgct gttttcatcc tttcttatca cgatatacga cattttatgc gggccaagtc 1983361 ccaaatggtt tgtgcaaacg cctatttcat gtaaggaaat aatgaaatac agtatgcacc 1983421 cgctcatatt ttttaaacgt cagcttttcg taaaactgag ttgcaccgtc agtgcttgca 1983481 gccactaagt aggctgcttc cattcctagt gatttggcga tggacagcat ttctttcact 1983541 aagatactgc cgtagccctt cctttgaaac tgatctaaaa ttgccacttc ttcgatttta 1983601 gccgttttct cttgatgatc gataaacagc tcgccgcacc caatgggaac tttctgtgcc 1983661 tggtcgctgt aacaaacaac aagaatgatt atatctgctt catagaaagg atattttctt 1983721 tttaattttt gttcagcgat tgcttctcca atataaatgg aatcgtaaat tttcataata 1983781 gaagatccgt cgctaagact ttttgccgtc ccccatgcgg ttaaaggatg tcccatctgc 1983841 cccttccagt cactaagctt catgtcatat agtagctcat cctcgacgac aaaaccgctt 1983901 tttacaagtg actgcttcaa accgagcgga aaaacatgct gcggcgacgc ttttaaatgg 1983961 agataattcg catcaagcag ctttggtacg gagggtaaaa agttaagtaa ccgctccaat 1984021 ggaaacgtat catggagctg aacaaagtta tgagaaaaaa tttgcggaag ctgcggatct 1984081 ctgtatacgc tgtaatgatc aaacgatgcc gattcagacg ttaacaatat atattgatgt 1984141 tccgtttttg aataatgtcc tgtcatgaac gtctcctttt tatgacctat acctttactc 1984201 tgttgcaata ttcaatttct ttataatctc atcgtacacc ggataaaacg gctttccaat 1984261 tggaaattgc tgaatatttc ggaaagaagc ggagattggc ttctgatgta aaaaaaactt 1984321 ccttgttact tgttcactaa tcgggtgaaa gacgccgttt agaaacaaaa acggctcgcg 1984381 ttcgatgaaa aacagacgtc ggccaggcgg atttttgatc aattcagatc gtttccacgt 1984441 aatcggcggc ccttccggaa gcgtctccat ctcttctttt ccaattgtca ctatgtcttt 1984501 tctttgaaat tgataaaatt gaaacgcata ctggtccaca attcgccttt tttttccggc 1984561 ttcgatataa aatattgcag gatggtcagc ttcctttact aaaatataat tcggaatgtt 1984621 taaaattttg ccaatcctat attggaataa atatgggtct ggaacagcga cagtccgatt 1984681 tagatacaaa aaaccccact tttctccaac aggatgcctt acaccctgat caaaaaaata 1984741 cacattttga tctgaacctt ttacaaaaga gccgtcaatc aaatcggcgg gcagaaaccg 1984801 atatgcattt tgaaatgaat ctggggtttt ataggttgtg tctaatactt catttatcgg 1984861 cagaaatggg gtaaagttgt tgagtctcgc ccaaaaaatt gcgtcgccat gattccaatg 1984921 cttcatatca tcatcccagt agcctccaaa tttatggtga atgagattaa gtaacgaacg 1984981 gcgatgcata actgagcaat gatcaacttg aaaagcggcc tgatcaagca ctgcattggc 1985041 atttctgtag aaatgtgaga tttcctctcc cctttcgttt acatgtacaa ctttttgttt 1985101 tgaatagacc gcctgcgctt caggcttatg tgaaaactct tgcaccatac ggctcagccg 1985161 ctcaggatga taaacagtgt cgtcagtaag ataggaaatg taatcgccgt ctgcaaatgg 1985221 gagcgcactg ttaattaatg tggcataacg ggctgttttt aatcgatctg caggatgcac 1985281 gaaactgtta tgatattgaa tgcgccggtc atggagatac ttgtgaatca ccgcagttgt 1985341 ttctgcattc gaatgatcat ccatgataaa aagctcccaa agatcatgcg tttgctgtat 1985401 cacgctttcg atcgcttttt gcaaataatc gggtttgttg taacttgtta aaataataga 1985461 cactttctct cccatctata ccgcctcccg ccgtcaaaca taaaaacggc tccgcagcaa 1985521 gcagagcctc tgtcatcatt taaaaagcac cccagcttac aacacttgag agtgaaacat 1985581 gagatctcgt gttatttaac gggttttgga aaataaccaa atcagtcaga acttctttta 1985641 cgatgacatt ttgaagtgta tctccgttga tcaaattgac ttttgaaacc ggtacgccca 1985701 gctcttttgc aaaaacaagc tggcgtctga ggtcagatgg atttccttca gaagacgatt 1985761 gacgtatcag cagaatcagc aaaagcaaaa taaaatgcag atcatcttgg ttttcttctc 1985821 gatccacttg tttctctaaa tccaaatcat ccctctccct tatccttatc tctgtttcac 1985881 aatatgtgcg acttcgattt atggtatagg ctatgtccac tccattaaaa aatcagcatt 1985941 ttccttaaat agatgaaaaa tagatcaggt acggcgttcg actcatacca aataacagcc 1986001 ggaagaatat gaataacgtg agttcactat cgaataggag gtgtgtgtaa tgagctctga 1986061 aaatgcacag ttaaaaaagg atttaattaa agccgtttta agccctttat ttccaactgc 1986121 aacagaagga ggagaaaata tggatagtaa tcttaaagcc ttgcttgatg ctgccatcga 1986181 tcaaaaagta gatgaaagtg aaacggttac ggcagaatct attttagacc cttctcttcc 1986241 ggcaagatgg atttttgcca gaattacgcc aggcactaca atcagcattg tgactgattc 1986301 aggtgacatg atcggaccgg ttgttttcgt tgctttcgat caggttcacg ggatcgtatt 1986361 tgtaacacag gaaagctccg tcactccggc aggccaagct acaacattaa ttgatgtaga 1986421 caaagtagaa agcgttacgt tcttttcata acatccgatg aaagtcttgt atatccagtc 1986481 gggatacgga ggaatataca gttattttga tcgctgggct gaagaatgtt ttcagaacac 1986541 tcatacagag tatatgattg cagataaacc tgaagcagaa tctttgatga agatcgaagc 1986601 gtttcagccg gatttcacac ttatgatggt tggagaccgc gttcctcacg actggctgac 1986661 ctggttaaag ggtaaggata tccccgtgta tgtttggctg accgaagacc cattttatat 1986721 ggatatcagc cttcaggtaa ttaagcttgc tgacgccata ttaacgatag aacaaaatgc 1986781 agctctctac tatcaagagc tcggctacca gaacgtctat tatgttccga taccagttaa 1986841 ccatcggctg tttaaaaaaa tgggcaccga acattcctat cattcaaatc tgttaatcat 1986901 cggctatcct taccctaatc gggttcagct tatgaaagaa gcggtccatc tgccattcac 1986961 ggttcgggta atcggcaagg aatggggaaa atatctgcct aaaaaagtgc tcaaacagcc 1987021 gcatattgat gtcgtcagca catgggttcc acccgaacag gccgttcatt attataatgg 1987081 ggcagacatc gtaattaatg cgcatcgtcc ctatcatttt gctttcaacc aaaatactat 1987141 gcgcatcaaa aatgccagtt ttaataaccg aacgtttgat atcgctgcat gcgaagcatt 1987201 tcaattaaca gatttacccg cggcgcatcc tttttcatcc attatttctt atcacggcat 1987261 gaacgacttt aaggaaaaag ccgctttcta tatcaaccac cctgaagaac ggcaaaaagc 1987321 tgcagcagcc aattataaag agaccgtacc cgcatttacg tttgatgagc ttcctgcaaa 1987381 actaaaagcg attcatctgg cgctttcttg aaaaatcgtt cattgctatg aacgattttt 1987441 ttattcatag aaaaaagcag ctgcacaagc tgctttctat tctagccgtc agaacggtct 1987501 ttcagcttcc tcggatttac ctgtttatga agatcaggca tttcgccgag atgctgtgca 1987561 atttgttccc acgatacaat tttgaaattt tgattgacgg cttgtccgtt atcaatattt 1987621 tcgccgtcct gcgccacaaa aatcccgtac ggatattttg ggccaagtcc gaaaccgaga 1987681 acatcaatac catccgtgtc actagtaccg tctatcttct cgccatctgt aatctcaaag 1987741 ttggctacat agcgattttt cccctgccgt tcatacattg catagctgtt atttccttga 1987801 cttgaagcca tgagatatcc tttgccattt ggtgcataat agattgtcag tccttcaata 1987861 tcagctgtca aatgatctcc tgtcgcacgg tcaacaacct gcccctttga ccctccgccg 1987921 ggctcagcgt taaatttcca gatggcctca tcttcctctg ctatgtatag gtttccgtac 1987981 tcatcatccg caacaaggcc ttcggtctga gaattcaact taaattcacg cacctttttc 1988041 cctgttacat aaccctttcc accatcaaca atttcatact gctcaaattc cccttgtttg 1988101 cctgtcacta atgcgtaaaa tgctcctgtt ttctggctgt gatacaagct gaatccataa 1988161 acctcagaaa tattggtgga aataggatgg ttcggatctg taatgctttt caattttcct 1988221 ttatccccgt ctattgcata tacttcaatt gtattttttc cttcggaccg gttggatgcg 1988281 gcagcaatat caattttttc gccgttcaat ggaaaatcat agcgcagatc gacattattg 1988341 agcttgccaa actcataaga atgaagctgt tttccgtcta aatcatacac aacgagccct 1988401 gacttcttat ttgttgtaat caacttgctt ttttccgggt gtttttcatg aacccaaatg 1988461 gccgggtcat ctgctgcatc atcgccagat gcgaccggat ctgtctccgt gtgtgcagtc 1988521 actttgaaat gatgttcctc attcacataa tgagccgaca ccgaggttgc tgtcaggcta 1988581 agcaataaac ccgcggcagt gcttagcagc attgtttttg gaaccttcat ttggtaccct 1988641 cctcttttat cactaacact actattgtaa aatatataca ggtgattacc gtgaggaaaa 1988701 tgaacctttt tttatagggt ttctgactca taaacaactt attccccaaa gaggtggtga 1988761 gatgactttg ccagatttac ttttgcggag cgaaataaaa atatgttgaa tatttagtac 1988821 attatttatt tagttttgtt tttccctagt tacgtccgtt tttccatttt ctattaaaaa 1988881 agaacacttt gtgacatgat cattccccta aattttgttt tattggttgc tttcattaat 1988941 tcgattacaa agttgaacat atgatgcatg gtagagaaac gagagttgga ggataagcca 1989001 tgcctaaaca gcaaacagca gaactaaaac catttttcca taacaaaaca gttttagtca 1989061 ctggcggaac gggttcaatc gggagtcaaa ttgtcaaacg ccttttgatg cttacaccta 1989121 aacaggtgat tgtattcagc aaagacgaca gtaaacagta tgtcatgagc caaaagtatg 1989181 cggaggataa gcggctatta tttgtacttg gagatgtacg cgatcacaga agggtgaatc 1989241 aggtgatgaa aggcgtcgat atcgtctttc acgcggctgc gctgaaacag gttccgacat 1989301 gtgaggacca tccatttgaa gcgatccaga ccaatctcat cggcggacaa aatgtggtgg 1989361 aagctgccct ttcacaccga gtgcagcatg tcattaatat cagtacagat aaagctgtat 1989421 ctcctgtgaa cacaatgggt gccaccaagc tgttatctga aaagctgttt catcaagcaa 1989481 accgccacgt ccaaaacaaa ggaaccttgt tttgttcggt ccgctttgga aatgttctcg 1989541 gttccagagg ttcggtcatc cccatattat ttgaacagat gatggagggt gaacctctga 1989601 ccatcacaga caaaaacatg accagatttt tcatgtcaat agacgatgca gctacattga 1989661 cattacaatc ggctgctatt acaaaaggcg gagaaacctt tattttcaaa atggaatcac 1989721 tgaaacttga agaactgatt catgggtttg aagaatatgc atcgcagcac gggctcccgc 1989781 ggccggctgc agtagaagtg ggcaagcgtc caggtgaaaa gcttcacgaa gaattaacat 1989841 ctccacatga aattgaatca ctgtatgaat ggggcaacct ttatgcgatc cttccagagc 1989901 cggaaaaaca tcctgacttt cgcaaagtca atctgcctgg gtatcaatca gatcaagccc 1989961 cgctcattac gaaagaaaga attgctcaga ttattgaaga attgcatcaa gagaaaaagg 1990021 cataaaaaca agcctgtcta tccattaggc aggcctgttt ttaacagttt atttattaaa 1990081 gagatgcaga tagctttcgt atccttcttc ttttagctta tgcttcggaa caaaccgcag 1990141 cgctgctgaa tttatgcagt aacgaagtcc gtttggcccc ggtccgtcat taaatacgtg 1990201 gccaagatga gaatcagcag ttcggcttct tacttctgtg cgaatcatgc cgtggctcgt 1990261 gtccagtttt tcttccactt cttcttcaat cggctttgta aagcttggcc agccgcattg 1990321 ggaatcaaat ttatctttgg atgtaaacaa tggcttgcct gacacaatgt ctacatacaa 1990381 cccttcttcc ttatgatccc aatattcatt ttgaaatggc ggctccgtgc cgttattttg 1990441 cgttacttca tattgcatgc gatttaatga ctttattttt tcttctttat tgtacgccat 1990501 ttatttagcc ccccaatgct cgctgataaa tcccgctcgt ccggaacctg tccggtagcg 1990561 ctgataatgt gctggattct ttttataaaa atgctgatgg tagccttccg cttcatagaa 1990621 aggttcagct tttaaaatgt ccgttacaat cggatcttta aagatgccgc tttccgccag 1990681 acgttgcttg gaagcttccg caagctcctt ttgtttatca ttatgataaa aaatggctgc 1990741 gcgataggaa ctgccgcgat cagcaaattg ccctccggca tctgtcggat cgatttgctg 1990801 ccaaaataat tcaagcagtt tttcataagg gaatacatca ggatgaaacg tgatttgaac 1990861 ggcttcacga tgtcccgtcg tttcactgca cacctcttcg tacgtagggt tttcagtatg 1990921 gccgcctgta tacccggaca ccactttttc aattcccggc tgttcgtcaa aaggtttaac 1990981 catacaccaa aaacagcctc ctgcaaatgt ggcgatttct tttttttcag acatactggt 1991041 gcctcctttg ttaatacgtg gtattattat attatagcat gtaaaaatag aatgaaaatg 1991101 attctgcttt tcaataaaat ctataggttt taagcaatat gcttatgtaa tggaggttca 1991161 caaatttgaa agtaagaaca cagatgatgt acgatatgga aactttactc cgtaaagtct 1991221 ttaaacaaat acgcaatgaa atcaatgaaa ttttagataa agagctgtcg cggaatgaat 1991281 tcaccattct tcgaatcctt agtgaacaag ggcctaaaaa agtcactgaa tttgcgccta 1991341 ttttagaggt atcggcaagc cacattacgg ctgtgaccga tgcgctggta gaaaaggaat 1991401 ggattacgag aatcagatcg aaggaagaca gacgcatcat ccgcattcat atcactgaag 1991461 cgggcgaaaa agtccttcag cactttaacg agaaaaaaac ggaatatttc tttaaacgct 1991521 ttgactgcta cactgatgct gaacttgcca cgttaatcga gctcttcagc aaacttgata 1991581 aaaaacggtg aaaaaaagca cataccgata tataggtatg tgcttttcgc agtgcttcac 1991641 ttatttttca gtaaacagct tcattgcttt ccagcggcca tatctataat acaaaaatgc 1991701 cgcgcagctg ctaaataaaa aactcattcc gattccaagc ccgattcctt tttgtccaag 1991761 ccaagctgaa aatagagctg tgaaaggata cctcaacacc caaaacgaga tcaaatttaa 1991821 taccagaacc tgcagcatcg ctcccgcggc cctgacgatt ccgttcagca caaaattaac 1991881 cccaataaaa gggtagaaaa acgcgatcca cttcaaatat tgttcaccaa atgcgaccgc 1991941 atcaggctca ctgataaata accttatgag gtatttacca aatacccaaa tcataaccgc 1992001 aatcaccagc atgcaggaaa taacagctat cacacctagc cttgcaattg ttcccactct 1992061 tttttcgttt ccgattccaa tattttgccc tgccatacta ttgacggccg taccggcagc 1992121 cattgctgga agcgtgatga tgctatcaag ccgctgcacc gcgccaaagc ctgataccac 1992181 gtgatccccg tatgagttaa caacactcat aatcgccatc ataccgcctg taatcaccat 1992241 catctgcaga cctgccggaa tcccgagttt caaaatcagc gcggactctt cccacttggg 1992301 cattctcgga atcgagaatg gcacaagctt gtgtttgatg acataaaaca acccatacaa 1992361 aaacgcaatg ccctgtgaca aaatcgttga ataagccgct cccgctattc ccatgcggaa 1992421 cacagaaata aagagcggcg caagcactgt attcagtaca acagcaaacg caataaaccg 1992481 gagaggtgtc ttgctgtcgc ccagcgcacg aagcacagta ctgataaagt tataaccaaa 1992541 caaaaataaa atgccgataa attgaatctg taaatacgtc tcagcaagcg gtatcattga 1992601 ctccggcgtt tttagaagac gcagcaaaag ctctgagaga aaaaaaccgg ccgcgccgaa 1992661 tccgatgctt aggcctgtta ataaaacaac aaaagcgtta atatacgacg ccattccttt 1992721 tatatcatct tttccttttt gctgagataa aatggttaac gtcgcattgt taaggcccaa 1992781 aataaaagac agcacggtca aaacaatcgt gcttgatacc gcggctgccc caagggcctt 1992841 tgcccccagt aaattgccga tccacaagct gtctataaat tgaaaggaaa cctgcaatgc 1992901 gtttccgagc ataataggca ttgaaaacag tacaagctgt ttcagcacgt tcccctgtgt 1992961 aaaatcgtat gctttcatct tttctccttg tgttctcaaa ttttcttcgg accacacgaa 1993021 aaaagagacg ttgtttcatg tctctttttt catgacttat cggttttttt tcggtctcgc 1993081 ataccgaatg taaacaccat cacacttagg aacaaggcac aataggaaac attcaaatac 1993141 atttgatcca tatcttcagc agccagatga tgataagcaa gccagccgaa gtacagggaa 1993201 aatgtaaagg ataataaact gaaatactgg taaatccgtt tcattttcag tcacctctat 1993261 tgtttaggat ggtaatagga aaactcaatt tcatcttttt ctaaatttat cttatccgct 1993321 ttgacataca ttccattcgt taaaggcatt tctgacaaac gcacttcaat gcttttatct 1993381 ccggggtgaa catggacaaa tgacggcaat tcataaaagc tgtccatata atttaacaca 1993441 aagctaattg gtatactcaa tttccctaac gaaaatttcg tgacattcag ctctacatca 1993501 ccgttttttt tcacggtcgg ctcaaaagcg ataaacgcat caatagacgt ggaaaatgcc 1993561 ttgattttcc ctgcgacatg aacatcatca tcaatctcta ctttataatc aagcttgttt 1993621 gatgctttgt cgtttaaata tgagttaaca aacgcagcta atgattcttt tgtgcttgtc 1993681 acttgaaatc catactcgct ctcagatgca tctttcacct gagcctgttc ccccggaagc 1993741 aaaacaagtg ccacaaaccc ggcggcgagg ataaaattga ttgcaagcaa tataaaaaac 1993801 agtcgcttcc acttattcat gctgtcaccc tactctttcg gtaatccttc ttttttaatg 1993861 gcttgataga cgcgctttgc gataagagaa taacccgtac cattaggatg aaaatcatct 1993921 tcctcagaaa ttcggctgct gtcacttttt tgattaaaca aatcttcgat atggacgatt 1993981 tttgcatgtt tatctttttt cagctctttt tcagcaatat ggttccaatc cgtgacgaca 1994041 ccatttattt catttagttc tgataatgta aacgtaaacg gattgtacat gctgacataa 1994101 atcagctcag cgtgatcatt cagctcgcga atttcagaaa tgattttttc aaagcgcttt 1994161 tcgtacggtt tttccgcttc ctgaaacggt tcaacggtta attgcagaaa gttttggcga 1994221 aggattttca tcaaatcatt accgccaatt gtaaaaaaga cataatctgc gtcctttatg 1994281 cctttttgaa cctttttatc ttttagtttt tctaataaat catccgaacg gttccctttt 1994341 acagcataat ttttcacgtc gaccgttttg acttgtttat ctgaccggat agaatccgcc 1994401 accttgccga catatccctt tccgtcggga tctccgactc cttctgtcag cgaatctccg 1994461 acagccgcta tgacaatgtg ttcttttgtt ttcgtttcat gggctttttg ttttccctca 1994521 gatgatgtac gtatgctcgt acacgcagta agaagcaaaa tcaaactggc catgattgaa 1994581 aaaatgcgca gcttcaatct tgttgctcct tcccattcta ctagtggaaa gtgtatcatg 1994641 ttttagaaga tttgcaaatg cctagtctct tagcttactt gagtgtactg gctgacttca 1994701 catcggaaat gatatcatcg tacggtgtat tctccactcc attgtaatct ttcagcacct 1994761 taccgtccgg acctaccaaa taaaaagaag attgatgaat cacttggtcc tctccctccg 1994821 gcttctttac gatcgcttta aagctcttaa gtgcgaactc ctcaatctca ctctggctgt 1994881 atcccgtgag aaaatcccag ttatcaaaag ataatggata atttgcggca aatttcttca 1994941 gctgtttcgg cttatcgttt tctggatcaa cactaaatga tatgatgcgg acatctatat 1995001 tttcggcttt cagttttttt tgcagatcgg tcatatgagc ggtcattggc ggacatatag 1995061 tttcacaatt ggtaaaaata aaatccgcca gccatacttc tccttttaaa ctctctaaag 1995121 aaacgttctt gccgtcttgg ttttgaaatg taaaaggctc cacctcgtaa ttgagcggat 1995181 ctttaatctg ctgtcctccg catgcacaca aaaacagaaa aatcagccca gccgttaacc 1995241 ccttgataac cttcatgaca tccatccttt ccagccagca taaaaacgct ttctaaaacc 1995301 gtccttactg tcccatgttt gtattcgata ctgagcaaaa aaaatcctgc atgcctcccc 1995361 attaacgatt acaaaggagg gcatgcaggt aaaaaacggc atgttacgcg ttgtgcttta 1995421 acacctcttg atgaaataca gcctgataat ctgcccactt catccgccgc ttcatataat 1995481 gtcggaaaga atacactttt gccctgctgt ttgatgaaaa cacttctttt aagtagaatt 1995541 gcaaatggtg atgtaacata aagaaatagt gctcatcttc ctttaataca ggtatttctg 1995601 tcactttcac ctgaatcccg tcaccgcgtt tgaactctag gcttttgagt aacaagctat 1995661 caatcctctt ttttgttttt cttctattat atatgatgcc agccgggctg tctgtcattt 1995721 tgcgcggttg tgtaaaaaaa ttagattagc aaatggaaca agtcctcatc cttgttcacc 1995781 tctacataat gaaacggttt tttgttcatc cgttcaatca gcggcccata atcggctttg 1995841 ttctgcagct cgatgccgac aagagcaggt ccattgcttt tattattttt cttcgtatat 1995901 tcaaaccttg taatgtcatc attcggcccg aggacttcgt caagaaattc gcggagcgcc 1995961 cccgctcttt gtggaaaatt gacgataaaa taatgctgaa ggccttcaaa aatcaaggaa 1996021 cgctccttca tttcctgcat tcttccgata tcgttattgc ccccgcttac cacacacacc 1996081 acgtttttcc ctttaatttg atccttgtac aaatcaagcg ctgcgacaga aagagctcca 1996141 gccggttcag caacaaccgc acattcgtta tataattcaa gaatggatgt acatactttt 1996201 ccttcaggca caaggagaat gtcatcaacg acagtttcca gcgtccggaa ggtttcctcg 1996261 ccaatttttt taacagccgc cccatctaca aacttatcaa ttttatcaag tgtgacgaca 1996321 tgcccagctt tgtttgattc aaagtaggat gccgctcccg ccggctcaac agcaattacc 1996381 tttgtatcag gagacacgtt tttcaaatat gtacctaccc cagagagaag gccgccgcct 1996441 ccgacacttg caaaaagaaa atgcggttct gtatcaatgt cgtttaaaat ctcgactgcg 1996501 agcgttccct gtccggccat cacatccgga tcatcgaacg gatggataaa cgtccgagat 1996561 tccgcctcac agcattcagc agcgctttta tacgcgtcgt caaacgtatc gcctgtcaaa 1996621 ataatatcga taaatccttt tccgaatagt tcaacttgag atactttttg tctcggtgta 1996681 gtagacggca taaaaatttt cccgtgaatg ccaagatgtt tacacgaaaa tgccacacct 1996741 tgagcgtggt ttccggcact tgcacacaca actccgttct ctgtctgctc gctggaaagc 1996801 tgtttcattt tatgataagc ccctctgagc ttaaaagatc tgacaacttg caagtcttcg 1996861 cgttttaaat agatattgca ttcatatctc tcagaaagtc tgtcattcct ctgcaaaggt 1996921 gtgtgaatga caacgtcctt tacgttttgg tgagccttca aaatgtcttt cacttggatg 1996981 agagagtttt ctttaagcaa cggtttcatg tacagattcc tttcttgttt taaatcccta 1997041 tttaatatgc cattataaca tgaatattca aaaaataaga caattatttt tatttaataa 1997101 ttaaaaaaat acagactatg tccaccacat cttgtggtaa cttctgttca accattatcc 1997161 tgcagagcca agaaaaaaga tgatcgtaaa ataaagggtg ttttcaacca aaaggcatga 1997221 tataatgaaa ccaattagaa ccaaaaggag ccaattgatg aatagtgcac caaaactcaa 1997281 tacatttcaa catctaatcg gagaacatca aacttttctg gaagcgaagc gaatcgccaa 1997341 gcagttctcg ttatcggagc ttcctgtctt aataacagga aaaatcggaa caggcaaaaa 1997401 tcacttcgca catgccatac acttggaatc ttcgagaagc aatgaaccgt ttataagcgt 1997461 caattgcagc acccattcgg aagaaaccct tattcatgag ctttttggcc ctaacggaaa 1997521 cacaggtgtt tttcaaaaag cggtacgagg aacccttttt cttgatgatg tatggcgcat 1997581 gcctgcttct gtacaagctc agctgttaaa agcgcttgat tcagacacgg agaaaccgcg 1997641 aatgatctgt gcttctgcag accgatccgt ggaacataca ttcaggcaag acttattcta 1997701 cagactgaac attttaacgc tcacactgcc cgaattatcg gaacgaaaaa gcgatattcc 1997761 gcttttgaca cagcattttc tctcaaattc tggtcagcaa ttgttaatcg atccctccgt 1997821 ttttcccgtg cttgagaagc atgcatttga aggcaatgtc agggaattaa aaaacgctgc 1997881 agattatatg gcggcagtat caagcggggg aacgattcag ccatatgacc tgccgccgta 1997941 tattagaggc acgatagacg gaaaaacgtc gaagaaaaaa gcgaaactgc ttactttaat 1998001 ggaaaaagct gagtttttgt ttattttgga aacaataaaa gtattgaacg aaaaaggaga 1998061 acctgccagc agacggatca tttctgaaca cagcaaaaat acccaaacct cgttaactcc 1998121 tcagcaggtc agaagccgtc tcgactattt ggagaaaaaa gattatgtca ccaaaagccg 1998181 cggacgcgca ggcacaaaaa ttacctttga gggcttgagc tttatagaga cgttaaaaaa 1998241 tcaaatgatc tagcgatcga aaggagaatg tacttgttta caatcaaaga agagatcgcc 1998301 aatgcgatta cacacggcat cggtgtcctc ttatccatcc cagcattagt gtttctaatc 1998361 atatttgcgg ctaattacgg gtctgcatgg gacattgtca gctttacaat attcggtgtc 1998421 tctatgctgc tgttatattt gagctccacc ctgcttcaca gcatcacaca taaaaaaacg 1998481 aaggacattt tggagattat tgatcatagc gcaatttacg tactcatcgc cggaacctac 1998541 acgccttttt tgcttgggcc gctgaaaggc acactcggct ttaccctgtt ggttatcgta 1998601 tggtcacttg ccctaggcgg aatcgttttt aaaattttct ttgtgaaacg gtttatccta 1998661 ttgtcaacct tcgtgtattt agtcatgggg tggctgatga ttattgcagt taaaccttta 1998721 tatgcttcac tgagcggagc gggattcagc ctcctttttc tcggcggcat tttatactct 1998781 gtcggaacca tcttttacat ttggaaaaag atccccttcc atcacgccat ttggcacagc 1998841 tttgtattgg gcgggagcgc tgccatgttt ttctgcgtgc tcttctattg tgtaaaggtg 1998901 cctttccttt cgtaacagta acagaaaagc gcagtcttca cgactgcgct tttttatgca 1998961 cgtaattgtt tttcattggc aggtatataa gcttttgaaa aggacaattc aatgtctgcc 1999021 ggttttaagc gtttaaaaaa cgagccattt tgcatgttat ctgttccttt cgtttccacc 1999081 atcaccaacg gaagatgata gcgggccgca agttctacag gatcaataga accatctagt 1999141 gaaagaatca ggctttgtcc cttttccagc tgttttgtca catcttcata taccttttct 1999201 gaatccccgt ctgaaatcac atccatccga tccagccatt gcccgataaa aggcaagcgg 1999261 aacacttttg ggttagcgat aaagccggcc ggttcctcaa tatatccagc aattaaggcc 1999321 agttcagcca aacgcaaacg gggatgcaca tacaaaacag gaccgtgtgg tattggctct 1999381 ggctgatgga tcgtcacaac tgaaccggag atgccgatac agccttctaa aaacgccttt 1999441 ggctgttcgt acacaagagc catctgtttt ttgtatgaca gacggggatc gagcattgtt 1999501 tgattaaata attgtttcat attttttaac agcatataca caatataaac cactagaagg 1999561 ctgtagcgaa ccaattaaaa tcctcccgct ttagaagaat tctttttttc atacattaga 1999621 aattcgtaat catacgggtt tttttcgtct ttggtcccct gctcagaaga aaccagcttc 1999681 caattggatt catcaaattc aggaaagtga cggtcaccct caaactcgtg atgaattttc 1999741 gtcatataca gtctgtccgc ataagggaac aggtccgtat agagctgagc ccctccgatc 1999801 acaaagcatt cttcagggcc tgaacaaatg tccagtacat cctttaatga actgacaacc 1999861 gtgcatccct gaaattctga atccggcgct gaggtaacga caatattttt ccgatttgga 1999921 agcggacgtc cgatcgattc aaatgttttc cggcccataa tgattgaatg gcccgatgtt 1999981 attttcttaa agtatgcaag atcattgggc aaatgccacg gcaaatcatt gtctttgccg 2000041 ataagcctgt tggcatccat cgcaaaaatg aatgaaatca tacgctgacc gcccctttta 2000101 tatgaggatg cggatcataa tcctcgatga taaagtcctc aaatgcaaag ttaaaaatag 2000161 aatcaacctt tctggcgaaa cgaagctgcg gaagcggtct aacatctctt tccagctgca 2000221 aattgacttg ttcaatatga ttttggtaaa tatgaacatc accaaacgta tggatgaact 2000281 cgcccggttc aagcccagtc acatgagcaa tgatcatggt taggagggca taagatgcaa 2000341 tattaaacgg cacacctaag aaaacatcgg cagagcgctg atacagctga caggacagct 2000401 tgccgtcaga cacatagaat tggaacaggc aatggcacgg cggcaacgcc attttatcaa 2000461 tttcaccaac attccaggcg ctgacgatta agcgtctgga gttcggattt gttttaatat 2000521 cttcaataag acgggaaatt tgatcaatgg tttctccatc agctccccgc caagaacgcc 2000581 attgggagcc atatacaggt ccaagttcac cgttttcatc agcccactca ttccagattc 2000641 gcactccgtt ttcctgcaga tagcgtacat tcgtatctcc ttttaagaac cacagcagtt 2000701 catgcgcaat tgatttaaag tggagttttt tagtggtgag catcggaaag ccttcccgta 2000761 aattaaatct catttgatat ccgaaagtgc tgattgttcc ggtcccagtc cggtctccct 2000821 ttttctcacc atgctctaaa acatgtctgc agaaatcctt atactgtttc atttttttca 2000881 tcctttaaaa gtagtcttct agtagtgtaa cacaataaaa aatcatttct gaacccagaa 2000941 atgatttttt tatagtcagc tgacgacagg cttttcatcc tgttcttttt cttcatcttg 2001001 cagatcctga tgcgtatgtg caattctgct cgccgctgct gcagcaagag ctgccacaat 2001061 atcatccaaa aaggtgtgaa taccgtctgg actttcatca agttccttaa taattccaat 2001121 cttctcttta tccaaataac cgaaattggt caaaccgatc gacccgtaca cattaacgat 2001181 tgaaagcggg ataatttcat ctatgccgta aagcggttca tccgtttcaa caaggtgctg 2001241 cagcggttcg gggagaagtt tctgttctgc aagctgatcg agtgcaaggc ctgtcaaaac 2001301 agcatgaata atttcacgtt tgttcaggac tttttctaca ttctccatgc aaacactgag 2001361 cggcagattt ggattgtatt tttcctgaag tttttgaaca atccgtgcaa tatcttctat 2001421 cataacgccc cgtttgttca gcatatcctt tgttatatcg accatttcat tcattgtgta 2001481 ctttttcatg tctaatggca tctcctttag gcactcatcc agttgggagg cgtgttgcgg 2001541 tcccagtaaa tgctcccaag ctcatgatgt gattgaaatc catcttctgc tgtatgataa 2001601 tgaaaattaa accagtagcc gtcatgaggc gggtggtctc ttcgcacatg gaatctgaga 2001661 agatcttctc cagttgtccg attgtaaacg ttgaaaattt tttccgtttt gcccgctgaa 2001721 ggcatgcttg agatcacaac atcttggtac gcctcatcat cttgcaatgt cgctaaataa 2001781 tcactaatca cattttcgat ttttggcagg atctctttcc gatagtcatc ctcaatgaca 2001841 ggagcgattc tgctgccgaa ttttaaaaag gactgatcct cagcgctgtc aaggagctgt 2001901 tccttgtacg attgaaaaag cagttcagga tctcgcctgt catccgactc atcatcgtac 2001961 aggtcatgct catcataaaa agcggtgtaa tcattctgct caagactgct cggctgtccg 2002021 gaaggcttgt ccgccataag ggcagccgga ggagatacga gcccgaacgt tacaatggta 2002081 aataaaacca caagggtctt tctcatccac aatttcatga ctgcttattc ctctctattt 2002141 tattgtcatg tttctcttat tttagcacat ccaaaacatg caagtcatgt actatatgaa 2002201 actgatatgc aaattaggag attcgttgct atgcactttg tgtaaaaacg cttacaatat 2002261 ttcatgaaag gaggctttcc gcatgattga cgctctgttt gccacagttt cactcttaac 2002321 attattatac tttgtcgtca tggaggtcac cgattaacag aaagcccgtg atatgaatca 2002381 cgggcttgtt tgaatgacgc cataatggaa cagtgctgtt tttcttttca tgacgttaaa 2002441 accaaactgt tcaaaccgcg ggcttttcca gtggtctttt agcacaacgc tttttctggc 2002501 gactcgtacc gcttcattga tacatccttc gtgcaaaacg gaatcctctg ccaaatcacg 2002561 taaaggcgcg atgccgtcag aggtttctac aggttcatga aacattggat cgaaataaac 2002621 cacatcaaca gagttgtcag ggagctgctt gatgtgttca aagcaatcac cattcttcac 2002681 ctggattctt ctcatcgcag cttgaagctc ttctataccc gtttcccatg aatgcagccc 2002741 cgtcctcact aaaacagaca caagatggtt tttttcaatc ccaacaacag aacccgtttc 2002801 gcctactgcc atacttgcga taatggcatc tgaccccaac ccgagtgtgc aatctaaaaa 2002861 cgtatcccct tcagataagc cggcagcccg aagcataggt tctttctccc cctgtaagaa 2002921 gcgtttggct ctgaacatcg ctgtattcgg atgaaaaaag aatttggcac cttgtttcgt 2002981 atacagctca aaccgctctt tgccgaccac aagcaaatca cgttcagctg atttcagcag 2003041 gtgctcaacc gtttgtttat tccggccgca gtatggcata tttagctctt tagaaagctg 2003101 ctttgcagtt tttatggtgt gttcagacgg tctatagctt gttgttatca tcttctgtac 2003161 tcccaaaaag aaaatgcccg gagaacgggc atttagcagt gcgcatcgaa ggcagcagtc 2003221 agatttttca tgatttcttc catatcgtgt ccttcaattt catgacgcgg aataaaatgt 2003281 acgacttctt tgcctttcaa aagagccatt gatggtgaag aaggctcctg gccagtaaaa 2003341 tactcacgca ttttcgcagt agcttcttta tcttggcccg caaatacagt caccgtattg 2003401 tcaggtgttt tgtcattctg gaggactgcc tgtgtagccg caggacgcgc aaggcctgcc 2003461 gcgcagccgc atacagagtt aacgactaca agagttgtgc cctctgcctt ttccataaag 2003521 ttttctactt cttccgctgt tgttaactct tcaaaacctg ctccagtcag ctcgcggcgc 2003581 atcggtacga caagctggcg catgtattct tcataagcca ttgacataaa aaaagccccc 2003641 tctagtatcc ttcatctgaa gtaaaggata ctatagagag ggccggattt caaatgttca 2003701 cgccttaaaa taaaagaaag tgtccccagc tatctagatt ttcataatac cgccggtgtt 2003761 ggcacttgtc acaagtttag aataacgtgc caggtagccg gttttcactt tcggttcaaa 2003821 acctttccag ttcgcttttc gtttttccca ctcttcttct ggcacttgta catccaagat 2003881 gcgtttttca atatcaacga taatatggtc tccgttttca acaaaggcaa gcggcccgcc 2003941 ctcagcggcc tcaggtgata cgtggccgat tgagaggcca cgggaggctc cggaaaaacg 2004001 tccgtccgta atcaatgcca cttttggccc gagtcccatt ccaacgattt gggatgttgg 2004061 cgccagcatt tccggcatgc caggtccgcc ttttggccct tcgtatctga tgatgacaac 2004121 gtcgccttct tttacttttc ggttgataat gccgtcaagc gcctcgtcct gagaatcgaa 2004181 tacgacagcc ggcccttcgt gtcttgtaat cccattctgt acgccgcctg ttttaatgat 2004241 agcgccgtcc ggagctagat taccgaataa aacagcaagg cctccctttt cagtgaatgg 2004301 ttgatccagc gggtgaatga cgtcataatc ctttacttca tgtccggcaa tggtttctcc 2004361 aagagttttt cctgtaacag tcagcgcatc taaatgaagc gctccttctt tcttcgaaag 2004421 ctcattcaga gccgctgaaa cgccgcccgc ttcgtgaaga tcttcaataa acacatccga 2004481 tgcaggcgcc agcttagcca agtgcggcac gcgctcagcg acttcgttaa tgcgttctaa 2004541 agagtattca acgccggctt cgtttgcaag ggcaagggta tgaagaacgg tatttgtaga 2004601 acctccgagc gccatatcga gtgcaaacgc gttatcaatc gcttttactg taacaatatc 2004661 acgcggtttg atatctttgc gaatcgtttc cattaattgc gcagccgatt ttctcacaaa 2004721 ctctttgcgt tccggagatg ttgccagaat ggttccatta cccggcaaag caagaccaag 2004781 tgcttctgac agacagttca ttgagttcgc cgtaaacatg cctgagcaag acccgcacgt 2004841 tgggcatccg aactgctcta gttcttgaag ctcgttttcg ttgattttcc ctgcttggta 2004901 ggcgcctacc ccttcgaata ctgaggaaag ggagattttt cgcccgtcac ttgttcttcc 2004961 tgccgccatc ggtccgccgc tgacaaaaat cgtcggaatg ttgatgcgca ttgccgccat 2005021 aagcattccc ggtgtgattt tgtcgcagtt cggaatacag accattccgt caaaccagtg 2005081 tgcggataca accgtttcca cagagtctgc gataatttca cggcttggca gcgaatatct 2005141 cataccgata tgccccattg cgatgccatc atctacccca atggtattaa attcaaacgg 2005201 aacgccccct gcttctctga ttgcttcttt tacgattttc ccaaactcct gcaagtgaac 2005261 atgaccggga acgatatcaa tgtatgaatt acacaccgca ataaacggct tgccgaaatc 2005321 ctcttctttt acccctgctg cacgaagcaa actgcggtgc ggagctctat cgattccttg 2005381 tgtgatcata ttactgcgta attctgccat ggtgatcctc ctaaattctt tcaattgttt 2005441 gattggattt tattttgaca attttcagtt tatttatggg ctgtttttgc aaataagata 2005501 aatacaggcc gccctcacct tgttttgttc tttcgtgttt ttatatttat atagctttct 2005561 ttcgatttga accctccaac tattaatatt gttacttact ataaatagtt ttcggatatt 2005621 tttcaacaat attcgaaata atttttataa aaagtgaatt cacataaaaa aggtgcatga 2005681 tctgcacctt ttttatcttt attcgccttt ttttctgctt tccgtcattt gtttccaaac 2005741 agaacctttt gcttcttctc catgctcaat acgttcaagc gccattttga cttgaaggct 2005801 gacctcaaat tcggggtcat cttcggcagc gcgcaaagct tcaattgcac tttcatcgcc 2005861 gacttcgtac aggaacatgg cggcacgcca gcgaacaagc ttgctggagt cgcttaatga 2005921 cttgatcata gcaggaatgg cttgaggatc gccgatatca gacaggcagt ctccggccgt 2005981 tcttctgact gatacagctt tgtcctcaag tgctttatac aatagaggaa gaacatcagg 2006041 tgtttcaatc attcctaagt acacaacagc ctgtcttctg atggacacct ttggatcatc 2006101 caatgccttc tgtaaaaccg ggatatcctc ttctttcgga tccatctgtt ccaagtgtgc 2006161 ataacgcttt ttccagtcct catcatccag catatcaagc gttactttat acgctttgcg 2006221 ctgtacagct tgttttgctt cgccctttcc ttgagcggct gcttcagtca gtcgtttcag 2006281 ccgttcatca ctgtatgccg cttgaagctc ttctgtcaca tcatggccga tttcatcaaa 2006341 gtcaccgaat ctgacacctt gttctttcca agcccgctca aacacaacat tggaagcttc 2006401 agatctaagt tttaagatcg cctgctgaaa gcgttcaggt aagccgaagc gttcttcccg 2006461 ctctccatcg gttaatttaa cttgcatagg aatgccgctg aacatctgca caaaaacttt 2006521 tacctctcca aaagattctt gatcagaacg attttcttct gcgctttcag cactttccat 2006581 cccaaatgca gtgcggactt gcggtaaaat gtctttccag tcgtatcttg cattccgttc 2006641 aacagcaaga aaatctgcga cgtgatatac ccctttaact ccatctattt taaggatttc 2006701 cgctataaca agcggtgcgc cttctgcttg ctcaggttta tagttattgc ttttgcccgc 2006761 cggaagctct tccgttaaga tgactttcat tgtattcggg cttggtgtag gttcaattga 2006821 ttttatcttc atgatcgtcc tcctatagca tatctgtgac ttattctatc atagtcgctc 2006881 caagccttct attacgacgt ttcggcatca atcccgggta tgtctttttc taattggcgg 2006941 acaaattgaa gcataaaatt gtgtctttct tctgccagtt cccgtgcagt gtctgtattc 2007001 atcatatctt tcagccgcag cagcttatga aaaaaatgag cgtaggcgct ttgctcatct 2007061 ccataaaggc catgcccttt tgcgcccgca aacatgaaag ctctcgcaat gccgacagca 2007121 ccaatcgcat caagtctgtc agcatcctgt acagcttttc cttcaattga gagcggctcc 2007181 ttcgccaatt tccccctgtc ccgaaaggac atccttgtta taatatgaat caccctgtca 2007241 gcattctctt ttcctactcc gaaaaaaacg agctgatcat atacttcgct cacagaaagc 2007301 ctgaccgtgt caggcagctt cacatcaatt aaatcatgaa ccaaagccgc cgtttcaaca 2007361 atgaacaaat ccgctttttc cttttctcca atatacgctg caagatctgc tactcttgat 2007421 acatgatgcc agtcatgtcc agagctttcg tcagtcagga tagattgaac ccatgtcctg 2007481 atttgctctg cctgcttcaa ttccttcaca aaaacaccct ctttttattg ctctaatagc 2007541 ttcacgatat cgtcttccaa ctctttcgga tttgtatttg gtgaataacg gccaacgatt 2007601 tctccatttc tatccactat aaatttcgtg aaattccact tgatcgcctt agttcccagc 2007661 atccctttcg catgttctgt caaatacaca aacagcgggt gggcgttttt cccgtttaca 2007721 tccacttttg aaaacatagg aaatgtaaca ccgtaatttg tttcacaaaa ttcctgtatg 2007781 tcagcctctt caccaggctc ttggttcatg aattgattgc aggggaaccc taagatctcc 2007841 agcccctcct gctgatatgt atcatataat tcctgcagct gcttcaattg ggaagtaaaa 2007901 ccgcacttac ttgctgtatt cacgatcatc agtacctttc ccgcgaaagg ctgaagtgtc 2007961 atgtctttcc ctgtgattgt acgtaccttc atatgataaa tagacatgta agtccctcct 2008021 atgtccttgg tgctgattat tttacctttt ttaaatcgca attcaaaatg taaacatcaa 2008081 ttaagaactc ataagaaacc taacgatatg agcgtcagtt cattatcaat tcatatggct 2008141 cgttttttat cttatcattc tataaaacat tacaattccc tcttacatct ttgaaaatca 2008201 ttttactgtg aaaccaaaag gcgtgtcagt gcgttttatt taaagagttt tctgttgttt 2008261 ccccctcaac acgtatagat agattgaaaa ttggcgtgaa aattcctata atgaagaaaa 2008321 ttaaacgggg aaataatgga ggtggcacgt tgcctattaa tataccaaca cacctgccgg 2008381 caaaacaggt gcttgaaagt gaacatatat ttgtaatgga tgaaagcaga gcatttcatc 2008441 aggatatccg gccgcaaaaa attattatat taaatttgat gccgaaaaaa atccaaacag 2008501 agactcagct tctcagattg cttggaaatt cgcctttaca ggttcatttc acatttttaa 2008561 tcccaagcac acacacgccg aaaaatactg cgagagaaca ccttgacgaa ttttacacga 2008621 ctttttccaa tatccgtcac aagaggtttg acggcatgat tatcaccggt gcgccgatcg 2008681 agcatttggc gtttgaagag gtttcatatt gggaagagct caaggaaatc atggagtgga 2008741 gcaaaacaaa tgtcacttca accttgcata tttgctgggg tgctcaagca ggtttgtatt 2008801 accattacgg tgtggaaaaa attcaaatgc cgaaaaaaat cttcggtgtg ttcgaacata 2008861 ccgttctttc aaaacacgaa agattggtaa gaggttttga cgagctatac tacgtgccgc 2008921 attcccggca tacagatata aatatggaac agcttcaagc agtgcccgag ttaaacattc 2008981 ttaccgcatc aaaggaagcc ggggtttgct taattgtgtc taaagacgaa aaacaagtct 2009041 ttttgacagg gcaccctgaa tatgatacaa atacgcttct tcaagagtat gaaagagatt 2009101 tggaacgaaa cctttctact gtcgaggccc ctaaacatta ttttgcaaaa ggcagcaacg 2009161 agccagtgaa tcgctggaaa gcgcatgcca cattattgtt tatgaattgg ctgaattatt 2009221 acgtttacca agaaactcct tatgaatggg actaattttt ctttttttag tgatacgctg 2009281 agcaaaaaat atgataaaat acatctgatt cagtctgcgt ataacaaaaa tttaaaatac 2009341 tggaatccaa atcatttaaa attagcttaa ctttttcact gcattaataa ttcgattatg 2009401 tatttgtgtt atgtttatgt atagacaata actccttacg atgcatgaag cttgcttgtt 2009461 gttgattaca ttgaggtgaa tttacttgaa taccaataaa agagtattaa ttttgactgc 2009521 aaattacgga aatggacatg tgcaggtagc caaaacactt tatgaacaat gtgtacggct 2009581 cggctttcag catgtaacag tttctaattt gtaccaagag tcaaatccga ttgtttcaga 2009641 ggtaactcaa tacctttatt taaaaagctt ctcaatcggg aaacagtttt atcgtttgtt 2009701 ttattacgga gttgacaaaa tctataataa acgtaaattc aatatttact ttaaaatggg 2009761 taataaaaga ttgggcgaac ttgtcgatga acatcagccc gatattatta ttaatacatt 2009821 tccgatgatc gtcgtgccgg aatacagacg ccgaactgga agagtcattc ctaccttcaa 2009881 cgttatgact gatttttgtc ttcataaaat ttgggttcac gaaaacgtgg ataaatatta 2009941 tgtggcgaca gattacgtga aggaaaaact gctggagatc ggcactcatc caagcaatgt 2010001 aaaaatcaca ggaattccaa tcaggccgca atttgaagaa tccatgcctg ttggcccgat 2010061 atataaaaag tacaatcttt caccaaacaa aaaagtgctt ctgatcatgg caggtgctca 2010121 cggtgtatta aagaacgtaa aagagctgtg cgaaaacctt gtcaaggatg accaagtgca 2010181 agtagttgtc gtgtgcggga aaaatacggc tttaaaagaa tctttgagtg cgcttgaagc 2010241 ggaaaatggt gacaaattaa aagttctggg ctatgtggag cgcattgatg agctatttcg 2010301 gatcacagat tgcatgatta ccaagcccgg cggcattact ttgacagaag ccacagccat 2010361 tggagtgcct gtcattctgt acaaacccgt gcctggccag gaaaaagaaa atgcaaactt 2010421 ctttgaagac cgcggagctg ccatcgttgt gaaccgtcat gaagagattc tcgagtcagt 2010481 cacttccctt cttgcagatg aagatacctt gcatcgcatg aagaaaaaca ttaaggacct 2010541 tcatttagca aactcctctg aagtgatttt agaggatatc ctgaaggaat cagaaatgat 2010601 gaccgccaaa caaaaagcca aagtgctatc gtaatggcgt acttgagagc atacgaaaat 2010661 cgtgtgctct ttttatttat attcagccat caataaaagc ggttacattt ttttatggaa 2010721 cttgcccttc ttttgaaaaa taagccgttt cgcaacttga cgggtgctcc cagatggtgt 2010781 atagttgaac catcatttaa caatgaatca aagttagatg atgacaaaat tttttttagc 2010841 acatgggtgc tacagtacta ggaggaatta agcaatatgc aaaacggtaa agtaaaatgg 2010901 ttcaacaacg aaaaaggatt cggcttcatt gaagttgaag gcggagacga tgtatttgtt 2010961 cacttcacag ctatcgaagg agatggatac aaatcattag aagaaggaca agaagtttct 2011021 tttgaaattg tcgaaggtaa tcgtggacct caagcttcta atgttgtaaa actctaaact 2011081 caatacatga tgatgagatg acaaatagag gagaggcatt cgcctctcct atttgatttt 2011141 catctggatt tcaatcgcca aaatgttttg tttacacctc tgttcaatct cttcaacata 2011201 cttttccatt gatggttttc cttttttcgc gatatcggcc agttcttcta aatcactgta 2011261 tatttctata aatgttttgt gaaggatcaa cttcaagtct ttatcatcca tagctgcgtt 2011321 ccccttctct atcaagatac ctcaaatagt aaaacggtcc tatttattct ggttcaatag 2011381 ttatatcggc ttatttttat tttcttttct attttggtac ataaatttca aaaaaactct 2011441 gcaaaataat ggcggaggtg ttttttgtga cttcagaatt tcataatgag gatcagaccg 2011501 gctttacgga taagcggcag ctggaactag cggtggaaac agcgcagaaa acaacaggag 2011561 ccgcgacgag aggccaaagc aaaacattag tcgactctgc ataccaagcc attgaggatg 2011621 ctagagaact gtcacaatct gaagagctgg cagctctcga tgatcctgaa tttgtaaagc 2011681 agcaacagca gctgctagat gacagcgagc atcagctgga tgaattcaaa gaataaaaac 2011741 cgcagcttct gcggttttta tttttagtga ttggttaaga catctccgta ttgtttcaac 2011801 ttttcaccaa ccgtacattt attgatacaa aatgaatgcg cataagtttt gccaaattct 2011861 ttgcgaaact gcttcttaat aaaacagtcc ttgcaatatt catcgtgcag ttctgtcagt 2011921 tctttaaaga tcattttctt atccaatatc gtcatctccg ttacggtcta atttcgtgtg 2011981 gctttctacg aattgatggg atagaatttt tttagcgagg ccgtcagctt cctgattgtc 2012041 ttttcgttgt attgtttcgt aggttggagt aagcttcagc gattcaagga gtgcttctat 2012101 tttgtccagc cattcattat gagatggatc ataacaaggc cagctgccgt caagctgatt 2012161 cagcacaaca agcgagtccc ctttgattgt aattgaattt ctgcttgccc caagctctct 2012221 tacttctctt attgcttcat aaagcgctgc gtattcagct tcattattgg ttttcagccg 2012281 gaagctttta ttttttctca agcgatgccg ggttcctccc aatgaataat agatgacgat 2012341 cccgagaccg gccagttcgc tctctttatc gaaactgccg tcaaaataaa cagtaatgtc 2012401 atcaggctct tgagcaagct cctctgtcag cttttccaat tccttcagcg tccagctgcc 2012461 gcctttctcg tcttcgaact ctagctcctt catgtatgga aaacggccaa gttctctggc 2012521 gaacgtacgt gcctgctgtg ctgtcagcca gtcttcgcta aaaaatgaga cggatcccgt 2012581 tccttttgct tctattttca aatgcggtct gagcttcatt acaatcacct taccattcat 2012641 tagttgccgg gcttatgcta taatcaaacc aatcttaccc cggaaaggaa gctttttcat 2012701 cttgtttaat aattcgtttt ggatcttttt tgcgatcatt cattttatca ttgttctttt 2012761 attttataaa ggatttggca aaatgggact gtttgtttgg atcggttttg cgacagtctg 2012821 cgccaacctc caagtcgtca aaacagtcga actgtttggc ttaacagcga cactcgggaa 2012881 tgtgatgtat ggcacaatct tttttgcgac agatgtgctg aatgaaaaat acggaccagc 2012941 tgaagccaga aaagcggtat ggctcggatt ctcaacgctc ctgacgctga catttgtcat 2013001 gcagggcgtg ctgcttttcg aaccggcttc cagcgacata tcacaaacag cgctggaaac 2013061 gatcttcgga ttccttccgc gagttgcgtt aggaagtctg cttgccttta tcttcagcca 2013121 aacgctggat gtttatgtat attcggcaat tagaaggata tttccttctg atcggctttt 2013181 atggctcaga aacggcggca gtacagcagt cagccagttg tttgatacat tcatattcac 2013241 tgcagtcgcc tttctcggca tttatccggc agacgtgtgg cttcatattt ttatttctac 2013301 atatttgatt aagtttgcgg tatctttaat ttcattgcct tatgcctatg cagccaaaaa 2013361 aatgatacct aatgatgaaa ggagttcata atgcctacag aaatatatgt agacggcgca 2013421 agcgccggta atccagggcc ttccggtatc ggcattttta tcaaacatga gggaaaagca 2013481 gaatctttct ctattccaat cggagtgcat acaaaccagg aagcggaatt tcttgcatta 2013541 attgaaggga tgaagctatg tgcaacgcgc gggtatcaat cagtttcctt tcgaaccgat 2013601 tcagatattg tggaacgcgc cactgagctt gaaatggtta aaaatataac gtttcaaccg 2013661 tttgtagaag agatcatccg attaaaagcg gcattccctc tttttttcat caaatggata 2013721 ccgggcaagc aaaaccaaaa agccgatctt ctggcaaaag aagcgattcg gctgaatgaa 2013781 aagaattaaa tcttgatcat tggttcatcc taatggcgag gtgaactaac atgaaaaaga 2013841 aagataaagg ccggctgacc ggcggtgtta ctccgcaagg cgacctggaa ggcaatacac 2013901 ataatgaccc taaaacagag cttgaggaga gagcaaaaaa aagcaataca aaacgctaga 2013961 gaggatctaa acgatctctc tagcgttcag cttttcaagc atacgctcaa ttcctttaat 2014021 ttggtggcgg cgaagcatgt cagccgcctg ctccatttgc aaagtaaata aagcgtcttt 2014081 cagtgtgcag gccagcggca ctgagcaatg gatttccgca agcttcctcg acatctccaa 2014141 atcgcttaaa ccttgctgaa tttttccctg ctgtcctttt ggaagaagag aaagattttc 2014201 caataaacgg tcaatcgttt cgtattcacg aatcagtttg taggctgttt tttctccaat 2014261 gcctttgact ccgggatagt tatcactgga atcacccata agcgctttaa tatcaatcaa 2014321 agccttcggc attacgcctg tttcttcata aaaagtctct tttgtataga ctttataatt 2014381 tccgattcct ttttgaagca aagcaacgct tactttatcc gttaacagct gaagtaaatc 2014441 tctgtcccct gttaccaccg taatgtccgc ttcattcgca aataaatcgg caagagtacc 2014501 gatacagtca tccgcttcat agccggcaaa gccaatattc atgattccaa gctctgcggc 2014561 tgcttccttt gccaaatcaa actgcggaat cagctccaca ggcggcgcgc tgcggttggc 2014621 cttataatct tggaacaagt catttcggta cgttttgctc cccatgtccc agcagcagac 2014681 gacgtgtgtc ggctggaatg tttccacagc tgtaatcaaa tgctttaaaa agccgttgac 2014741 gccgttcgtc ggcaccccgc tgtcatttat cataaagttg cgatgtacgg ccgtggcaaa 2014801 aaaggcccgg aataaaagag ccatgccgtc aaccagcaat agtttattat tattcatcaa 2014861 ataactccct tttctttcat tccttctatt ttatcataaa gcagcccaaa aataaaaaac 2014921 agtatctctt taattagaga tactgtttga atatttatca atcgttgtgt cttttgttgc 2014981 tggcgatcag cttttcagct tcgcgtcctg cgtaagagtc aaaatgggtt tgaaatccgt 2015041 ttttcttttt ggcgttgtta ttcgcctgtg catttctgtt tccgagcttt gttctgccca 2015101 acatgaatcc ccccttacgt cggatgcata tagtatatgc ttccggcagg aggttcactc 2015161 gcgacaggat catccagctt acatgcggct tacgtattct ctgaccattt cttttgatac 2015221 aagccgtctt gtcgggacga tgcctttttt agcgagctga ttcatttgct cggtaatttc 2015281 attaattgca tctgtagtat aaggctcatc gtttctgcat ttagcaacag cttcttcaat 2015341 cgccaattca cgcatatttt caagacgcat aaatgctttg atatgctcgt gctgttttga 2015401 tgaatgtgct gaaattgctt tatgtacctc tgacattaat cgttcatctc gcttttttct 2015461 atttagtcta tcatgacttg aaatacaagc caactgaatt ttacattttt attgtattgt 2015521 ctgaattttt ccaggagatg cacgcctgat acgccatttc aatctctttc gcatgttccc 2015581 cttccgcata tcctcttaaa tatgtctctt tttgatccgt tatttgcgcg attgcttttt 2015641 cacccatatc ttcctgtaag cgtctgaggt gagcagtgta atgagatatc aggctttctt 2015701 cttcattttt tatccatgcc tctgtgattt tcgtaagttt catccgtaca gcttcgataa 2015761 aggtcgcttt tcctttctgc tcaaaaaact gcttcggtga tttgatctct tttagttcct 2015821 gctcaaaagc acgttcttct atttccggtt caacttcctt caactgtatg ccgttcgaat 2015881 gctgatcacc cgcataaacg gaaaaataac cgtcctcgtt taatgttttt tgaaaatgat 2015941 ccagccattc ttcattgata tgccgttcga tgaaaccgct catgcgaaca tcaagcgttt 2016001 tgatttcctg aatatattca aatagatatt catgtaaggc tgttgtcatc gctttactga 2016061 cgttcttttt ccaatccccg ttttgcagcc cgggatgaaa tgccgatttt aataaatcat 2016121 ttgcaaaata tgataatcgc tgtgcaatgt gatatagctg ctctcttgta tcttttttta 2016181 ctttttcaat gatggttttt gagttccgcc gtttctcgat atcggccgct gtccgctcaa 2016241 atgacagcat aaggcactgt ttctgcgctt ccttctcttc tcgggactga tgctgggatt 2016301 ggtgaagctg aaaaacagtt tcgcatagtt tgtctgcctc cgaactgagc tgcgctgctg 2016361 acgctttttt tacatccact tcgataaacc ggtctaagtg ttttcttact ttcgagaact 2016421 gattataaaa tgactccggt tttcccacca gttcctcctt acttgatacg gtaaagagct 2016481 gcggctcata aaccccttct tttacaagct ctgcgctgac ataatcggtc actgtttcga 2016541 gctctgtttt atcttttgca aggtctgcag cattaataat aaaaaacatt ttatccatgc 2016601 tgagcgattc tttcacaagt ccaagctttc gcaaaaatga acggtctcct tttgaaaaag 2016661 agtgctgata ataagtcata taaaaaaatg catcagcatc tttgatatat tggaatgcca 2016721 gttctgtatg ccgtttattc atgctgctcg cgccgggtgt atcaacgatc gtaatccctt 2016781 tttcagtgag cgggcatgta tagtagaccg ttacctcttt cacagcacag gccgttgttt 2016841 cctctgctac atacggcttt aattcagaga gcggaatcgt taatttcttc tgttcctgta 2016901 tatactgctg atacttctcg tatgcaagca ggaaattgct gatcaatttc acgtgttctt 2016961 cctgcagcct gttttttttg actgcctttt cccacttctc tgtgaaggaa cggcctgccg 2017021 gctcctttgg tattccggtg agctgcaaaa tttcagccgt taagtcatcc tctgtcttaa 2017081 acactacatt cgctgttttg tttaagttgc cattgattgg ctttgtgatc ttgttaattg 2017141 tcgctgtggt tggcgttggt gaggatggca gcactctttc gccgacaagc gcattggcaa 2017201 atgatgattt ccccgagcta aagcctccaa aaagagcgag tgtaaatttc cgttcctcaa 2017261 gccttttcac cctttcacga aacgctgaag tttgctttaa caacatgctg cattcgccta 2017321 aaatgtcaga caaagtgtaa aagcgtttga tttggtcttg aagcggcatt tcttgttcca 2017381 ttttgatttc tgatttcggc atcggctgcg ccgtcagctg gcttcggcct tgtttctgct 2017441 ctggagccgc cactcttgtt ttcttcgatt taaaccattc tgtgtctata tgcattgggc 2017501 atgcggactc ttcttcccaa atggcccaca ggcgatcggt tttctctcgg gcattattct 2017561 ctaaacgtgc ctgttcttga agaaagacaa gtttttctga ttcttggacg agccggtcgt 2017621 taattgtttg cacatctttg gaaacacgct ctttcaccat agcggagagc acctttatga 2017681 tgtctgcggc ttctcttttc gcctctttcc ggatgagctc tgccaagtct tttgtatatt 2017741 gcaatacata ttcagaggaa aaggctgcac catgcttgac cgcgtgttca atgatgctta 2017801 tatcaagcgg tgtgcgatag gcctgaatca gcttttcact ttcagcggta tagacatcaa 2017861 ataccttggc gagtttatga agcgtgtcta tcatatgcca atccgcttcg gcctctgttc 2017921 gttttgccac atcagagaaa aaagcattcc gccttttatc tctttcctgt gcagttttcg 2017981 ctttagaaaa gaaaaagccg gttttaaagg aaggctcttg tgattctaaa aatgcagccg 2018041 ccaattcacg catttcaaaa ggcgtcaggt tggcgttttt taaaatacga ttgatttctt 2018101 cctgcatcct cttctctgcc tcagtcattt gtttttcggc ctcatccaat tgatcacgca 2018161 gcgattggac cagtccagta tggatattaa gctgttcagc gaaactcgga gcgcctgttt 2018221 cgtctttctt cagcatttcc gtatgttcct ttagcagatt acggactttt tgttcggtta 2018281 aagcctgcat attgcttttt gattgctgtt ctattctgct taactcttct ctcagggccc 2018341 ccatctgatt gaacgggtga tccggttctg ttactgatgt aaaatagagc gcttcccttg 2018401 aaatcccttc attgcaaagc atctcctcta cctgcgcttg atagtctcca aatttcgtct 2018461 ccgtctcatc atggcggtca atttgattga cgataaaata cacattcgga atgctttctt 2018521 ttattgatct gagaaacttt acattttcct cagcgtgcac gtgattatag tgaacgacgt 2018581 aaaacagcgc atccgcttgg tgaagaatag aagcagccga tagaaaatgc gcatcatctg 2018641 ttgaatctat ccctggagta tcaatatacg caaccccgga atcgatctca gtatacctgt 2018701 caaaaatttc gacgctttca atctgttccc cgtctttaca atattgctgc accttgtctt 2018761 tctggtaagt cccttccagc tcagcacacg ctccgtctgt tgtatgaagc cgaactcgct 2018821 tttccccgtt tctgatcaca acaaggttag cgcttgtcgg aatcgggctt gtcggcaaaa 2018881 tattctccat taacaggcag ttcagcagtg acgatttccc cgctgaataa tgcccggtaa 2018941 acgcgatata aacctcttca tcagccgctt ttttcatgac cgcagccagt ttagcagccc 2019001 tttgttcatc ttgattctca ataaattgct tataaagttc cccggtttta tgcaaaagct 2019061 cttttctgtt ttgatctgtc ataagtctga acccctttgt gccgtttcaa ttgtgaacct 2019121 ttttcgaaag atctgaattc attccctttt cattttacac aagaataaac caaatttctt 2019181 taggagaata gaaaaaagcc gccattacgg cagcttctat aaaagaaaat ctgcaacttt 2019241 tacaagttcc agattcatca aacagattta ttagagattc cttttaatac aaaaccaatt 2019301 aatacactat atgtacaaac cgctccaagc aaaaacagca ttgtcatttg cttcaccatc 2019361 ctgattgaga atctttttca aacccatttt aacatggttg agaatgattt tcaatcgcta 2019421 ttttacgctg tattcctgta atgctttgtc ttctgcgcga attctgacgc ttaacaacac 2019481 ggcattgaaa atggaaaaca gacacatggt gacgtatgct tgataaagca gcggaatcag 2019541 caaaatttcg aggataacaa cggcatagtt tggatgtttc atccatttat atggaccttt 2019601 ttttacaagc tctacacctg gaacaacaag gattttcgta ttccaatatg ctcctaagga 2019661 acaaagcgcc caataccgta cgatctgtac gcttaaaatc actgcagcga taccgagcca 2019721 ccagctggac ggctgtttat tcatcagcag cacctcggca attaaggaca ggaaaaaaag 2019781 gatatgcatc gtaatgatat acggatagtg gctctcgcca aattcaattg ctccttgctt 2019841 ctttaccttt tgttcgtttt gcctggccac tgccatttct gctgctcttt gaacaatgag 2019901 aatggcgatc aacaaccaaa acatgagtca ggcccccttt tcccagctga ataatagcaa 2019961 ctctgatgag aaacccggcc ctaatgcgcc aatcagtcct cgttcagctt cctttttatg 2020021 tccgttctgc agatggtctt tgatcacata caagattgtg gctgaagaca tatttccgtg 2020081 cttttgcaaa atgctttgcg cagatgaaag cttttctgac gacagcccga gacttttgat 2020141 gtatgcatcg atcacttttt ttccgcctgg atgcgccaaa aaaacactga tatcatggaa 2020201 tgacagctta tgtttgtcca aaaaaatctg tacatttgtt ttgagccatt tttccaccaa 2020261 ggtcggaatg tctcgtgaga aaatgacttt gaatccttga tcggtaaagt cccagcccat 2020321 gacatcttct gattgtttca tcaaaacaga ttgggcgtcc attatcttcg gcgcaagctt 2020381 cagctttgac accctgcggt ccgccttctc tccgcataat aaagctgcgg caatgccgtc 2020441 accaaaaagc gaggtgccga tcagattgct ttttgtttta tcttccggct ggaatgtcag 2020501 gctgcacagc tcggcagaaa tgacaagcac aaaagcctca ggatacgctt tgcagtattc 2020561 ggctgcacgc gcaagtccgc tggctcctcc tgcacagcca agcccccaaa tcggaatccg 2020621 cttcgtatat ggagaaaacg gaagttcatt cataagccgc gcctcgatac tcggtgtgga 2020681 aagacctgta ctggagacga aaaaaacagc ttccactttc tcataaggaa tggcttcttg 2020741 aaaaaattcc ggatgagaga ggcactcacg aacagccgct ctgctgtgtt taagtgtttc 2020801 ttctatgtat atttgatttt tttcttcaaa gctgtgcccc tctttatacc attcaatcgg 2020861 cttaacaaac tgtctcgaat ggatttgccc gtttttaaag gaggataaca gcctgtcaat 2020921 atccttaaaa gaatgctgaa acatatagcg ggcgaactcg gccgctttct cttggtttac 2020981 attatacgca ggaagacttg ttccaatgga taaaataaac gccatgcgat cacctctttg 2021041 catacattgt gccgcaacaa tcttttttat atgcaaaaaa aactccgccg cggcggagtt 2021101 agactgctgt tttttgttca gcgaggtcag cttcttgttc tattttttta gctttagaaa 2021161 aaacgttata tacaatattt aagacgactg cagtaaagct gcccgccaca atgccattcg 2021221 ttgtaagcag cgttaaggca ctcggaagct gtttgaaaat atccggcaca acggtcacac 2021281 cgagccccaa tcccactgag caagcaacaa tcagcagatt ttcctgtttc gcaaaatcaa 2021341 tgcggctgag cattttaatt ccgtaagcaa tcaccattcc aaacatcgcc accattgcac 2021401 cgcccaaaac agcggatgga ataatagtcg tgaaagcagc gatctttgga aacagcccaa 2021461 atgccattag gatcacacct gtgaccacaa tgacggcatt ttttttgatc cctgtgagct 2021521 gaacaagccc gacattttga gagaatgccg tgtaaggaaa agcgttaaaa ataccgccca 2021581 gaagcacagc cagtccttca gctcgatagc ctttagacaa atctatctct gtcaaacggc 2021641 ggtttgtcag gtcacctaaa gcaaagtaaa caccagttga ctccacaagg ctgacaattg 2021701 caacgatgga catcgtaatg ataggcgctg cgtgaaaaga cggcgctccg aagtaaaatg 2021761 gctgaatcat ttgaacaact gccgcgtccg aaacattatc aaattgaact tttcccataa 2021821 aatatgcgat gaaggtgcca atcaaaatac cgatcaaaat cgagacggac ttgataaagc 2021881 cttttgtaaa acggtataga agcacaatga tactcaacac ggtaaaagca agtgcaagat 2021941 tggagagatc tccgaaatct gcacttcctt ctccgccggc catgttattc atggcaaccg 2022001 gcatcagtgt aataccgata atcgtaacaa cagagcctgt cacgaccggc ggaaaaaacg 2022061 atacgagctt tccaaagaaa aatgaaataa gaatgacaag aatgcctgaa gcgataatgc 2022121 tgccgtaaac tgttgaaacc ccatattcag atccaatcgc tatcatcggc gatacagctg 2022181 taaaggtaca gccaagcact accggaagcc cgatcccaaa aaatcggttg ctccacactt 2022241 gcagaagtgt agccacaccg cacataaaaa tatcaatcga tactaagtaa gtcagctgct 2022301 cgacagtcag tcccattgct tttccgacaa tcagaggaac gacaatggcg ccggcataca 2022361 tggcaagaac atgctgaatc cctaaagaca gcgttttgcc gaatccattt ctcatgaatg 2022421 aacctcctgt acgaaggaca cttttccttc ttctaaagac tgaattcttg ccaaagattc 2022481 cactcggtag cccagtttta caagttcatc tcttcccggc tgaaatgact tttcaataac 2022541 aatgccgatt cccgcaatag aagctcccgc ttgcttcaca atcgacacaa gcccgtgcgc 2022601 tgcctgtcca tttgccaaaa aatcatcgat aatcagcaca tgatcctgat ccgacaggtg 2022661 ggtcccagac actgcgattt ggctttctgt ttgcttcgta aaggaataaa cagacgctgt 2022721 cagcaagttg tcggtgagtg ttaacgattt atgctttctc gcgaagacaa ctggcacacc 2022781 cagcttcaag cccgtcatta cagcgggagc gatacctgat gattcgattg tcacaatttt 2022841 ggtaataccg tcttttgcaa acctagacgc aaattcatca ccaattctct gcataagcag 2022901 cggatcaatt tggtgattca aaaaagaatc cactttcaat acctgatcag ataatacgac 2022961 gccttcttcc tctattttcc gtttcagtgc ttccatcctg tctacctccg ttatgagaat 2023021 aaaaaaagca ttgcccgctc aaataaagag caagcaatgc tgatatcaca aaaaaccgta 2023081 cacgtgcggt tccattgctc acccatagtc ggacatttac ggtgcccggt agaaacttgc 2023141 gtgccatatc cacgcgatta tatgagtgtt cctattatat tgtaataaat tatatcaaga 2023201 ttctaatctc ttgcataggc tgaaaataaa aattcccgaa ctttaatttt gtttttttag 2023261 atatcattcg tatttcaagg ggattcgata taaaagagtc tgacgaccgc gccgccaggc 2023321 ttttgattat aacagataga gatttgaata tttgtttgat aaataatcaa ttaaatagcg 2023381 aacattcagc tcttctcctg ttgcatcttt aataatgtct aacggctttt tccgttttcc 2023441 gtgaatgtgc accttttccg tcagccattg ctttatcgga tggaactctc ctctttccaa 2023501 gagagcgtca aattcaggga gatcctcaag cattttttgt ttcagctgag ccgcatacat 2023561 gtagccgagc gcataggatg ggaagtagcc gaaatctcca cctgcccaat ggacgtcctg 2023621 taaaatcccc tctgcgtcgg tctgcggtgt aatccctaaa taatcctggt atttttgatt 2023681 ccaaagcgac ggcagatctt ccacagacac ttcattgctg aaaatcgctt tttcaatttc 2023741 ataacggatg atgatatgaa gaggatacgt caattcatcc gcttcgaccc tgataaatga 2023801 aggttttgat tcattgattg cccggacaaa atcatccagg gagatgtcct tgaactgtac 2023861 aggtgatgcc tcttgaatct tcttatagta cggagtccaa aaatgcttgt tgcggccgat 2023921 aaaattctcg taaaataatg attgcgattc atgaattccc atcgatgcgc cgtctgacaa 2023981 gttcgtgcca ctgagtgctt catcaatatt ttgctcgtaa atcgcgtgcc cgcactcatg 2024041 aatggtccca aagatcgccg tccggaaatc tttttcatca tatctcgtcg tgacccgaac 2024101 gtctccccga ttcagcgtag ttgcaaacgg atgaacggtt tcatcaagtc ttccgccatc 2024161 aaaatcgtag ccaagctcct gtaaaaaata cagactgagc tctttttgct tttctttcgg 2024221 gaacgctttt gtaataaagc ttgtatctgg tttatttccg gaagctgtca cctgtttaac 2024281 aagagggata atcgcttcct tcagctcagc aaacaactga tcaagcacct ttaccgtgac 2024341 gccgggctca aacaaatcaa gcaatgcatc ataaggatgc tcttgatatc cccaatacgt 2024401 aataaaacgt ttattgaatt caatcagctg ttctaaataa ggagaaaaca agctgaaatc 2024461 agattttcct ttcgcttcct cccacgctgt ttctgccttt gaacacagaa tcacgtattc 2024521 tttgtattca gcctcaggga ttttcttatt ctcttcatac tcttttttcg ccagttccac 2024581 tgcttttttc gtatcttccg acaagtcatc aaatcgttca tacaggacat cgataagctc 2024641 cttcattcga tctgatgttt ggatattgaa tatatctgtt gaaagctggc cgatactttc 2024701 ggcacgatcc tctgagccat ttttcggcgc gcctgttctg gagtcccagt gcattaacgc 2024761 aactgcttcg ctgtaatgtg agattctttt taaaagatca aaaaattctt tttcatatgt 2024821 atgtatctcc atatccattc cctccctatt ctagccgttc cattacaggc taatggaagg 2024881 gggtatgaaa gtcaaattgt ttgtataaaa ggctgccggt atgttttgtg gcagcctttt 2024941 tattcagttg atcgtcattt gattttttgg cggaggtgtt ctccgctttt tctgcttgat 2025001 ttttttatct acccacactg ttgccagcgg ggttaagagc gaggtgacaa taacgcttgt 2025061 cgcgataatt gcagttgccg actcagcaac tggcgcaaat gaggcattcg cttccgctaa 2025121 tgcatatggc acggctacag ccgcccctgc cgtagaagaa gcggccactc ccgcgacacc 2025181 atctccccgc gcaataaaac gatcaagcaa aaacaaagaa ctgcccgata aaatgacgac 2025241 agaaactccg ataaaaatgc cgagcagccc tgattggatc agcattccaa aattcaaggt 2025301 attgccgagc gaaaaggcga aaaatggaat gatcgccggc acaaccttgc tgaataagtc 2025361 tctgagatca tgatccagat ttccaagtat acatccaagt aaaaacggga tgactgtcgc 2025421 tgccagcgtt tcccatggga atgcggcaag tcccgtcaca ccaaacgtca ccatggtcat 2025481 aaaaggacca gattctgtac tgataaaggc gaaagcgccc gcatcctctt ttcttcccat 2025541 gtgattcatg agcgccaaat acagtccgcc gttcgtttca ttcattaccg cgacaattgc 2025601 taaaacagaa aggcctgcaa aaaagccgga ttgtatgcca tcgtcaggta taaattgcgc 2025661 tgcgatcacg ccgagcagcg ccgcaaatcc gatcttcccc aataataacg tgattccttt 2025721 tcttgcgata tagcctgaag aacgaaaatc aatcgttgct cctacgcaaa agataaaaac 2025781 acccagtatc ggcagcgttc cggtaatcaa agcacccgta aaccctccaa agaactccgc 2025841 tgttccaggc gcaaacgtgt tgagcgccgc tccaagaaat agcggaataa tcatcattcc 2025901 gccaggtacc cgttcaattg tcgccttgat tttcatattg tggattctcc catcctccgg 2025961 ttatgaaaaa acaattccac ttacacttgg aaaacagcct gcaaatcctc ttttgaacag 2026021 ctgcccaact ggctgccgac tccgacggcg ccagctccgg ctctaagcca atcaggcact 2026081 tcagacggat gtatcccgcc tgtcggaata aaggtcacct gcgggaaagg acccgctaaa 2026141 tttttcataa acggaatgcc aaacacaccg cttgggaaca gctttaatgt cgtaaaaccg 2026201 aatgtcagcg cttccataat ttcgctcgga gtcaagacgc cggggatata atgtgtcttt 2026261 acaaaagata gatgttcagc aagatcagct gaaaaacccg gactgacaat aaactgcgcg 2026321 ccagccttag cagcttcccc agcttgctgc gcgctgatga ccgtacccgc gccaattaaa 2026381 atatcttccc tattacggaa ggattcgata atatctgatg ccccgggggt cgtatacgtc 2026441 acttcaactg cacgaatccc tttatctaat aaactctcaa tctgctgaca ggcctcctgc 2026501 ttatcctttg aacgaatgac tgcaatcagc tttgcttctt tcagacggtt ttcaacgact 2026561 ttggactcca tattaataat cccctttctt ttggtgaacc gttctttgag cagataaaaa 2026621 agaagctaat ttctccctgg tcggcaaacc gtccatatcc cccggtgcct gcacttgcaa 2026681 agcgccaatc gcatttcccc tttgcaccgc atccttgtac gacaaaccgt ctaggatacc 2026741 gctgattaca ccgactgcaa atccgtctcc ggcgccgacc gtatcaacca cccggtcgac 2026801 ccggcagcct tctagaaatc cttcacttgt ccccgtttta aagtaagcgc cttcttttcc 2026861 aagtttaata gcaacaaagc tggcaccttt tttcaaataa tagtcggcaa tgccttcagg 2026921 tgttttttct ccggtcaata gctctccctc tgcgataccc gggaaaaacc agtctgcaag 2026981 cccagccaga tcattgattg tgtgtaccat tgttgcttga tcaggccaaa gcgaaggtct 2027041 tacattaggg tcgaatgaaa tggtcttccc tgcgtttctc atgtcgttca tgacatgata 2027101 cgtgaagtct ttcatctcgg ctgataaagc aggcggaata cctgtcacat gcaaatggcc 2027161 tgcgcattga aaataatctc tcggatattc agctgtagtt aatgtgcttg cagctgagtt 2027221 tttcctatag taggtaactt gcgggtcgcc ttctttcact tttgacttca gcagcagccc 2027281 ggtgggattt tcgtcctgcg agcggatcac gcgggacaca tccactccct cttttttaag 2027341 ctcttgtaaa ataaacgttc cgagctgatc attgccgacc ttgctcatcc atcccattcg 2027401 aaatccgagt ctggcaaggc cgcaggcgac attgctttct gctccggcaa gccctttaga 2027461 aaaagtggat acttcatgaa ggcctccata ctcatttgca taaaacatgg ccattgattc 2027521 cccgaatgtc accgcatcaa gcttcatctc ttcccaacct cctcttagtt gagggcacct 2027581 aggattaaag tgactttctc atgatgactt ttgcctctaa ttcaatggtt tgaggcgctc 2027641 ctttgtcacc ttcaatcctt tttaatacac gttccatcgc cgtcctgccc atatcatgtg 2027701 acggctgggc gatcgttgta atgcctggac cgatcagttt gtaccactcc gtatcatcga 2027761 atcctgcaat ccctatatct tgagggatgc gcaggccaag ctcttccata cagctgatga 2027821 ttttcagcat aatcaagcca ttcaaagcca gaatcgcttt tttttgctcc ggcatttcct 2027881 tgtgaaaaga acgaagctcc gccttaagct gctccttgtc ctttacgtca atttcatgca 2027941 atctgacaag cccgttcaca ttttgaaccg aagccatttc ctgatacaca gctgctcttt 2028001 ctgcacgagg gctgatagag gaaatcggtt cggtaaacag cgcgacatca gtataccctt 2028061 tgctgtacac cttctgaaga atctcttttg tgatccatct gttgtcagtc gttacggtat 2028121 ccagtttcag atccggcagt ttccggtcaa ttaagattgt tggaatttgc tgttcagcaa 2028181 aagcgcggag tacatccttg ttttcccctg ttgcgtttaa aatcaagccc tcaaccgaat 2028241 gggcttctag ctttaagagc atttcccgct ctttttcagg actgttatct gtgttgcaca 2028301 ccataatgct gtatccatat tgatcacaaa cctcttcgac tcccctgaaa gcagcgaccg 2028361 aaaaaggatt tgtaatgtca gccacaacaa atccgattaa cttgcttttt tttattttca 2028421 aaccttgtgc cattttactc ggccgataat tcaattctgc gattgccttt ttaatgtttt 2028481 tcactttttc aggagaaatc gcgtcaattt ttccgttaat atagcgggaa actgtcgatt 2028541 tcgaaactcc tgcacattca gctacgtctt tgatggttgt atggcctgtt gttttctttt 2028601 tcattcaagt gctcctgtat ctcatatatt tgaaaccgat ttcaaaaccg ttacaacaaa 2028661 agaataccat aattttaaaa tttgggaaga gtttttttaa taatatgtca attcattatt 2028721 ttttcgttga ctcttttcac tatttatcct aaaattttct ttgaaaccgt taccaaaata 2028781 ttttcattca agtgatgctg aaatcctaac caagggggaa atataatgga aaatcgttat 2028841 tctgtacatc ctgaacaagt aaaacgcttt acaacagagg agcttcgcag tcatttctta 2028901 atggattctt tatttacaga aaacaaactt acgatgtatt actcacatga agaccgggtt 2028961 gtcatcggcg gagcggctcc agggcaaagt gaactgaagc ttgatgcagg tgattttcta 2029021 aaaacagact tctttttgga acggcgtgaa atcgggatta ttaatgtcgg ccagcctggt 2029081 gccgttagag tcggcgatga tgaatatgtg cttcaaacaa aggattttct ctatattgga 2029141 atgggcaatc aggatgtatc gttttcaagc ctgaacgggg aaaaagcgaa gttttacttc 2029201 gtctccgctt gcgcccacaa aagctatccg acacaaaaag ccgccctatc tgaactgaca 2029261 ccggaccgcc ttggtgatga tgcagcgtct aatgtcagaa gtctgtacaa agtcattcat 2029321 caggatggca ttaaaagctg tcagctgatg atgggaataa cgatgttaga tcaaaacaac 2029381 aactggaata ccatgccagc acacgttcat gaccgtcgga tggaggctta tctttatctg 2029441 gatcttgaaa aggactcaaa ggtatttcat ttcatgggcc agccggacga aacacgccat 2029501 cttgttgttg gaaatgagca ggctgtcctt tctcccgctt ggtctattca ttctggcgca 2029561 ggaacatcaa actatagctt tgtgtgggcg atggctggag aaaattacac atttacggac 2029621 atggatctca ttccaatgga tgggctgaaa taagatgggt tatctacatg acgccttttc 2029681 attaaaagga aaaacagcgc tggtgacagg cccgggaaca gggatcggtc aaggaatagc 2029741 caaagcccta gccggggctg gcgctgatat tatcggcaca tcacatacaa gcagtctgtc 2029801 tgaaacacag cagcttgtgg aacaggaagg ccggatattt acatctttta cattggacat 2029861 gagcaagccg gaagcgataa aggattctgc agctgagctg tttgaaaaca ggcagatcga 2029921 catccttgtc aataatgccg gcattattca tcgggaaaaa gcggaagatt ttccagaaga 2029981 gaactggcag cacgtactga atgtcaatct aaacagcctg tttattctga cacagcttgc 2030041 tggcaggcac atgctgaaaa gaggtcatgg aaagattatt aatattgcct ctctcctgtc 2030101 ttttcaaggc ggcatcctcg ttccggctta caccgcgagc aaacacgctg ttgccggttt 2030161 gacaaaatca tttgcaaatg agtgggcagc gtcaggtatt caggtcaacg caatcgcccc 2030221 aggctatatt tctactgcga atacaaagcc tattcgggat gacgaaaagc gaaatgagga 2030281 cattttaaag agaattcctg ccggccgctg gggccaagcg gatgatatcg gggggactgc 2030341 agtctttttg gcatcacgtg cttcagatta tgtaaatgga catattttag cagttgatgg 2030401 cggctggcta tcccgctgac aaataaaaaa gctgacgaac gatcgtcagc ttttttccat 2030461 tacatcatgt gcggttcaac aggcaagacc tttttgacct catcaatgat gcgttcattt 2030521 tctccgccag cgtaaatgtg aatcgagccg ctgtcttgat tcgagcgaat caggcgcccg 2030581 atgccctgcc gtacacgtaa caacatatat ggcagatcaa cttcttcgaa cggatctttt 2030641 ttcgctccgt tgcgcttcgc tgtaaataca ggatcgtgtg gcgggaacgg taatgaccaa 2030701 atggtaacat tcttcaatgc gtcaccggga atgtcgagtc cttcccataa gtgaactgaa 2030761 caaagtactg tttcttcttc ctcttggaat ttctctacta agctgctgat ttcctcatca 2030821 ccttcgaaga aaattggata cggcagctcc catgccgccg acagctcttt aaactcgttt 2030881 aattcttcaa aagaagggaa aagcaccagc gttcttcctt tgtatcgttt gattgtttca 2030941 atcgtttcag ccgttttttg ttcagcgtcc atatctgttt ttgcgtatag attaatactc 2031001 atttgctcgt cataatcata aggggaatca acagttaatg acaaataatc atgaatccca 2031061 agactgtcgg caatataatc aaacgaaccg ccttctgaca gcgtagcaga agaaaagata 2031121 taaggaattt tcttagaaaa cactttttcg ccaagtactt ctgctaccgt tctcggcatc 2031181 acgacaaagg ttgattctgc ttcctttttc tccagccagc tgatcgcatc cttttgatat 2031241 agagataatg aatacgccat ttgttcaaca tattcttcca ctactgacag ttcgtattga 2031301 tcaatcgtat acatttcaga ctcaaataca agtgcctcac cgattttatc aagtaaacgg 2031361 caaagctcgt ccgccgcctt tttgacacga tggtcatttt ttatttctaa acggtgtgaa 2031421 ccggctactt cctttgattc ttcagaaaga acatagaaaa attcgtcgtt tgcgagaagc 2031481 gcatcttcaa tcaattctgc aaactcttct ctgatgtcat tttgcagcaa tcgttctaaa 2031541 aacaattcaa gagtagactg cttcactcta taggttagcg ctttttgcgc agcaaactct 2031601 aacaagtgcc cctcatcaaa tacaactgca ctatgatcag gcaagagcgg cagctggccc 2031661 tctcgtttgc gtgattcttc cgtccacaca tgctccatat aaaaatcatg ggaacaaatg 2031721 attaagtccg ttgacttgcg gtagtaatct ctggaaagtg tcagaccgca tctgtgtctc 2031781 atatcacaag tcagacagtc ctgaaacgag tcgtagctta cgtcagacca ctcttcattc 2031841 gatagatttg cgtactgctt acggtcgcca tacggataaa agcgctgcat cgcctgggac 2031901 tcgtggacaa atgacggtaa cgactcataa agatccagcc atttatcatc atcagaacgc 2031961 tgcattgttt tttcaagctt cttcaagcat aaatattgct catgtgattt tgacagcctt 2032021 gtatcaattt tcagatcaag atgctcagcc agcttagaaa tatcgccctc ttttttcacc 2032081 agctgttcaa ttaatgtttc atccgcacaa gcgatgatgg caggtttgcc gacatacctt 2032141 gcatagctga ttgcaaaaag aagatatacc agcgttttcc ccgttcccac tccagcttcg 2032201 gcgaacatga cttttttctc tttaaacgcc cgctccagct gaaaagccat aaatacttgc 2032261 tcgtcccgaa gatcaaaccc tttttcggga aggatatcgt aaaacacgtc accaatccaa 2032321 ttgttcaatt cttcataaaa attctttgtt ttcgttaaag aaaaaggcaa acgtgatgtt 2032381 gtcacctagt tccaaccccc aactattcga cattcagacc accaataata tcattttccg 2032441 ctgatgaata caataaaaaa cttggcaatg ccaagttttt tgcagtttac ttacgattga 2032501 tcacatgcga cgataaaaaa ggatggtctg ttgaataaat atgttctacc gctttttcta 2032561 aatcagtttg cgcatgcgaa atcacagacg gagacgaatc agtcccgagc tccttcagct 2032621 cgtttgctgt tgcgtcaagc gccctttgaa taagattaaa atgttcgctg ttcagcatga 2032681 gatcacctct gatggaaata atcatcattg tatgcgaact tttcatttta tatacatgct 2032741 ttaccgcatg ttatcaccga aacatgcaca aactacactt gatattccgt ctccggatta 2032801 tccgtcttat caacaatatt ctatcaggga gtgatgttga catgagttat agaaaccgat 2032861 tagatcagca ttctgaactg tttcatcaca attggacgcg gcctaaacgt tcaaagtctc 2032921 aagtaaacgg tcacactgaa atgtcccaaa ccaacattat attgagaagc aacgcgaaag 2032981 ctcaccgttg gtaacgatag aatagggctg aaagatgaaa gaagacgcat gcagagcgtc 2033041 ttctttttat gcgttttctg ttttcttgcg ctgcggtctt acttttgacc agtattgata 2033101 ataatccgtt ttaataaacc cgttaaagag ttttcgtttc ttcgttgctt ttctgccata 2033161 tgcttcctca aagttttcat ttgatgtcag catatacaca gaccaagtat caagcggctc 2033221 gaacgcctgc cccatttctt tgtacatctg ctcaacggct tttttctcgc cgagacgctc 2033281 tccatatggc gggttgccga caattacgcc aaattccaga tttgtggtaa agtctttgac 2033341 ctgcatctgt ttgaactgga ttagatctcc caatcctgct tcctctgcat tttcttttgc 2033401 gatttgaacc atgcggtggt ctatgtcgct agcgaaaatt gtaagcggct gatcataatt 2033461 tgccttttct tcgacttcaa gccgcgcttt gttccacaga tctttaccga tccattccca 2033521 atcctctgat acaaaatcgc ggttgaatcc cggggcgatg ttttggccga ttagcgccgc 2033581 ttctatcgcg attgttccgg agccgcagaa aggatcaaca aacgggcggt caggcgtcca 2033641 attggttaat tgcaccaaag cggcagcaag tgtttcttta atcggcgcac cgccctgatc 2033701 gacacggtat cctcgtttgt gaaggcccgt ccctgatgag tccagtgtaa tcaaagcctg 2033761 atctttcaat aaagatattt ccactttata ctcagcacct gtttcttcaa tccaatcatt 2033821 ggctttgccg gactgcagct tgagcttttc gacaattgct tttttgacga tccgctgaca 2033881 gtcaggaacg cttgcaagtg ttgattttac cgattttccg atgacaggga atttcccgtt 2033941 ttcaggtata aatgagcgcc agttaatcgc tttcgttttt tcaaacagtt catcaaatgt 2034001 tttcgcttta aaagaagcaa cctgaacctt tatgcggtcg gctgttctaa gccaaaggtt 2034061 cgcacggcag atggcaagtg catcaccttc aaaaataact ttcccgttat caaccttgca 2034121 ttcgtatcct aaatctcgta cttcctttgc gacaacagct tcaatgccca tcggcgccgt 2034181 tgcaattagt gtatacttct tcatcgtatc accctgtctt ttaaaacttt tctcttttca 2034241 agataaaagc tctccttata cgggagagct tgttttcatc attttaaatg taagtggtct 2034301 aacgttctgt aagccatgtt ttgttccatc gtactgcaaa cggctcatca cctcgtactc 2034361 aggcggcaat catctatcta cagaaagcat tctgtccttc tctccgttga attccgttaa 2034421 gaaggttccc ctaccaaaat ttgggtttct cgctcgaggg gtttaccgcg ttccactctc 2034481 accatttcta gtgagacttc gtcactgtgg cactttcaag gatactcagc catatccgaa 2034541 gacgtaggct tttttcctgc cgtcagcctc taaagactgc cctagcttat gacttcgcta 2034601 ggcacgaaca ctacgggcat ctcagcaccg tgcgagcatg gactttcctc tacagattca 2034661 agatctgcag cgattacccg aacgttaaga acatgaatta ttatataaca actgattaca 2034721 atttacaagc gccatttttt tcaagcgtga tcaatcataa agcttgctgc caaaaacgtg 2034781 tttttctaag ttagacagcc gttttaaaat atcaaagttt gttgtgttag attgcacagg 2034841 ctgttttttg ctggcttctt caagctgttt tttcagctgc agattttcct gctgcagttc 2034901 ttcaatttct tgatggaagg tttcataatc cttaataatc atatctaaaa atttgtcaac 2034961 gtcttcttgc ttgtagcctc taacgcctgt tttaaattct ttttccaaaa tttctttcgc 2035021 agaaagcttt actttatcag caagcatctt tttcacctcg tatcgtgaat catcacatat 2035081 attttttcag aaatctgtac ggttgtcaaa tttctctctc attgttagta gctgtcttcc 2035141 tccactgtca ctctcaagtc atccattgta ataaagtaga tgggatagcc atcctgttcg 2035201 cgcctttttt ccgctgtccc aagcatatac ttaggggagc cttccttttc cgggtcatat 2035261 aaaagcagaa gcccgtcgga cttatcaatg aagaactgat ttttttgttt gaattgaagc 2035321 gggctttcat aaggacggtg agtcaggctt gcttcatagt ctgcctgagc cagaactgct 2035381 tcatactgtt ctttattcgg ttctttccag ttcttttcct gctcgtaaaa tggtgtgatg 2035441 acagctacct ttaagtcagg gtattcctcc tgcaaatcat atgcagcttc tgccgcccac 2035501 agctcaactc caagctggcc cgaaattaaa atccattcta atccttcatc caaaaaagca 2035561 atcagccggt ttttaatggc tttttttatg taatacagcg ccttgtcatc ctgcttaaat 2035621 atccccagtt caaacggttt atagcccgtt attgccaata ctttcatcat ttcacctgct 2035681 ttaaaaaatg gggctcccgt gggccccatt tgttgtgctg cattgtttac accatcaagc 2035741 tgcacgtttt ccatactagt agtcgcagca aggttttcct gcttgaaaat gctgatgcgt 2035801 agccgggtca acatttgaga aagtgtgtgg aaagtagtga acgtgctgaa aatgctggtg 2035861 gtttacgttt gttgtatgct gtgggtgaat gtgcggcacg atagtcttcg aaaacgtatg 2035921 gtgttcacag caatgagtag gatggacaat tggcgccatc atatgcggtc tgcagtgatg 2035981 catgataaaa tcccctttcc ataaacttta ttacaatact aagttatgaa aaataagggg 2036041 tacatgttct gatgcaaaga cctattttaa aagtgtgcaa ttaagctgtc tttaaagttt 2036101 gaaaacacaa aagcaatcaa aaataccaca acaaagaaca agtaaaaaac acccttatac 2036161 ataccaactc tccctttaaa aataactaac gtcattttac aggattcgcc gctattctac 2036221 aacaaaatca atgtgaattc agcaaaaaaa attcatggcg aaacaagtcg tcttttgcgc 2036281 tttcccgggg aatatttaag aggaatattt cctctttagc cgggcaattc tcacatgcag 2036341 tttttcagtt tctttctctg ataagcatgc cgcatcgcta agcgattgct ctgctacttg 2036401 caatgctttt ccgaattctt ttttcttatg ctcaaaatat ttcgcgagct ctattacagc 2036461 agcgtatctg cacttctggt tttgcgagcg ggacagcttt tcccaaagcg gcactgcttc 2036521 ttccaagcgg ttttgttttt tgtacaggag cgataaatcc agccgtgcac tgtcctggtc 2036581 ctcaaacgat ttttctataa gcctttccaa ctgcttgatc gcttggtccg tttctttatg 2036641 agccataaac catttcgcca tagcataggc ttcactgtgt tcttttggcg catgtgattc 2036701 tgaaaggatt tttttagaca tatggatgta caatgaaatg agtgataaca catccatttc 2036761 attatgatgc aggacacctt ttaaaagatc cggctcttgc gccttgataa aatgaaagta 2036821 aagcattggc gccaagtagc ccggtgtgtc ttctagcctg cggatgccga gctcctcttt 2036881 ttcaaccgtg ccaagagata cacggtccat tttgtgtttc cacaggcgtc tagctccatg 2036941 caaaagatca aagtggccaa actccggaag cttcggaagt ctgtcacgga tcaaggtgtg 2037001 ccttgttttc acctgcggcc aatcaaaggc tttgccgttg taggtcacaa gtgatgtaat 2037061 gtcaacctcg cttaaaaagc tttggtacaa ggcgacttcg ttccccggtt tgggcaaaag 2037121 atgctgtttg actgtcactc ggtcttcata tactctcgca tgcccaagca aaaaaatggt 2037181 attcccagct ccacccccaa gaccggttgt ttctgtatca aagaaaaaga ggttgttttt 2037241 gttataccct tttgctgaca atgtatgcga caggccgctt tgattccaca gtgtgatcac 2037301 ttcctcaagc tcagaaaagc tgtataaccc atggcggtga gaaagcggat attctacttc 2037361 tctgatgagg caatattcat cttcgaagat gaaaggcttc atgccaaaag cctcccactc 2037421 ttctaaaaac gggatgtcat caaagtggtt ttcttgtttg cctgcttcta ttttttgttc 2037481 tccttcgtcg agcgccatgt gctttttcat ccgttggagt ttccctttta atgacatatc 2037541 cggcctccct ccttacgaca tttgatccaa cagctgcaaa attctttcct ttgcttttat 2037601 cccttctatt tccgtaccta tacaagacgg acagccgtca tgacaaggac aatgtgtaat 2037661 cagttgtttc gccgcttcat taatgtctga aaaacgttta aagacttcct ccgccaaacc 2037721 gataccgccc ggataatgat catataaaaa tatggttggc aatccggtat gggctgcttt 2037781 aatttgagaa acaacatgaa catcatttcg atcacacatg atatacacag ggacaatatg 2037841 ctgcagcaca ttcgagatgc caagaagcag ctgttccagt gtcttttccc cgatgtcttc 2037901 atccgctgtt ttgatttcga gccaagctgc acttgtatgc agttcttctt ccggcaaatg 2037961 aataggtcca gacccaatat tttcaaaagt ggtcattttt atttttttaa aaatggtcgg 2038021 cagggcattg acagtgacgt ctccgtagtg caatgacgta cggctttttt ctttcgtttt 2038081 atcgatttct aataccttca gctgaactgc caggtttgca tccgtataat attcgacatc 2038141 gacttttctg acatacgcct ttttatggtc ccaatcgagc ttctcaactt gatactgaac 2038201 gccttcatgc aaataaatcg cttcatcatg caaaagcgtc atcgcactaa aacggtccat 2038261 ttcaccgata atccttacat ttgcaatatc cgactgatca actataacga cattttcctg 2038321 ggaggcggaa cgcaaactga tgtttgacgc agggaacgac tcacttgccc aatggtaccg 2038381 ttcgccgttg cggtgaagaa cagcctcttc ctgaagatac tcaagaatat cactgacttc 2038441 catggctcca aattcttcat cagctctaaa aggaagctca taagccgcac actttaagtg 2038501 gtctactaaa ataatcaaat tctccggatt gattcttgca gattccggcg aacgattaaa 2038561 gaaatattca ggatgccgca caatatattg gtcaatcggt gttgaattgg ctaccatgat 2038621 aatcaaagat tcaccgtgtc ttctgccggc tcgtcccgcc tgctgccaag cacttgcaac 2038681 acttccggga taccccgtca ttacacacac ttgcagctgg ccgatatcaa caccaagctc 2038741 taaggcattc gtactgacca ctcctaaaat gtcgccttct ctcagtcctc tttcgatttc 2038801 tcttcgctct ttcggcagat agcctccccg atagcctctg attgattttg ttccaatctc 2038861 ttttttcaca agctcctgaa tatggcttaa aataatttcc acccgaactc tgcttctggc 2038921 aaaaacaatg gtctgcactt tgtttttaag gaactctttc gccagttcat tcacttctgc 2038981 ggttgcgctc cttctaatat tcagcggttt gttcacaatt ggcggattgt aaaacacaaa 2039041 atgcttgcgt ccgctcggtg cgccgttgtc atcgaccagc cgcatcggtt tgcctgtcag 2039101 ctgctctccc aattcctttg ggttggcaat cgttgcggaa gtacaaataa aaactggatc 2039161 acttccataa aaccggcaga tccgcttcag ccgccggatc acatttgcca catggctgcc 2039221 gaacacacct cgatacgtat gaagctcatc gatgacgata tacttaaggt tttcaaacaa 2039281 actgacccat ttcgtatgat gcggtagaat ggcagaatgc agcatatcgg ggtttgtaat 2039341 gacaatatga cctgcttttc tcaccttttg tctgattgcc ggagacgtat ccccgtcata 2039401 tgtaaagctt ttaatatcaa tgcccatttc atcaataatt tcatttagct cgctcttttg 2039461 gtcttgtgcc agcgctttag tcggaaataa atataacgcc cggtttgttt catcttgggc 2039521 gatggactgc aggactggga ggttgtagca taacgttttt cctgatgctg ttggcgttac 2039581 ggtaacgatg ctctctcctt tttgcacata ttgaaaagcg gaatattggt gagtatatag 2039641 ttcatcaatg ccccttttcg aaagggccgc tttgattctc tcgtctatac tttcgggcat 2039701 aggccttgtt tttgcttccc gaggctcaat ttcatgccaa ttcacaacgt tttcatttcc 2039761 ttttaaatca gaaatgagtt cagtcagtga tttctttttc attctttaca cctctttgtc 2039821 aagtacagtt taccgaatat ttgtttgcat ggctaggtgc aaattttata cagttgaata 2039881 aaaaaagcaa ggcatacgcc ctgcttattt cgcttttatt gtaaagagct ttgattcgcc 2039941 tttacgagca gccttttcgc ctgccgatac cattgatcct acagcctcac cattcattat 2040001 aacgattggg atgactgtgc tgctcgcttt ttcttttatt aattccaaat cacatgtaat 2040061 cagcgggtca ccgaccttca ctttatcccc ttctttaatg tgggcagtaa atccttctcc 2040121 gttcatattg actgtctcca gcccgacatg aattaacagc tcaattcccg agcgagtccg 2040181 aatgccaacg gcgtgtttgg tgtggaaaat ctgaatgact tcaccttcag cgggagaaac 2040241 gatttcaccg ctagaaggtt ccaccgctat tccttctccc atcattttct gtgaaaaaac 2040301 agggtccggt acatctgaca ggtccattac tgtaccgtct gccggagaat aaataacctc 2040361 ttctgtcacc ttttcctgaa ttttgcccat tccgaataat tttttcagca atgtattttc 2040421 tcccttctca ttcacttcaa ccgttatccc ttcattcacc actatttaac cacactttca 2040481 attttgcttc aatttataac aacatctggc atagacgcat aatctggtta aaaaaggcgg 2040541 tggcgatatt ggaattccat gatgacaaaa agaacgaact gcaaaagaaa gaagaaatca 2040601 taacggaggc aatcgacact ctttttcaat cctcagcgtt cggcaacctt ataaacggat 2040661 ttcagaacct aatcaactcg agtttaaagg atgtgcagac gaccatacat gtcagagaaa 2040721 gagatactgg gctgtatatc gatattacca ttccggcgac gtttcgagat ggcgagatcg 2040781 tcgttgatgt taaatcgagg tatctccatg taacactcca agaaaaacag aaacaccaaa 2040841 atgaggctac ctttacaagc atgacaagaa cggttcagct gccttatgaa gttcgccaag 2040901 aagatatgga aacgtcttgg aacgagcaga caatgacact tttctttcca aaaaataagc 2040961 atgaatgaac gattcattca tgcttctatc atttaaaaaa gctggtaaat ccctttatta 2041021 aagatccgac ctgattcatt gcactcatta cttgacctgt cgtatccatc attttattaa 2041081 aatcaaattg cccattggct tttttgaact gcgacataat gctttgaaat tgtgaaggct 2041141 gctgttgatt aggccttggg ataggataag ggttagaaaa tacaggcggc tgcataggca 2041201 taggctggat cggagcataa ggctgataat aatcctgctg tccataatgc tgctgaggca 2041261 gttgttgctc taaataaccg ggtgcagcct gctgataata tccttgcata tgctgaggat 2041321 aataatagcc catttgccga ggatagcttc gagagctccc gttcattgcg attcccccct 2041381 aaacacaaca tatttctctt ctatatatgt atgaatgact tctattgttt gtgtcacaag 2041441 tgatgattag catttgtcaa attgtgtcga aagtttaaat tttttaaaaa cagaaaaaag 2041501 tcgaatcatt atggtaccat attttcaata cagatgagag gggatgcacc ataatgaacg 2041561 tatcatactt aagcaaacgt tttgcagaaa tgaagaaata tgaaacagac tgtatgaata 2041621 aactgatgga ctttgccaag ttcctctata ttcaaggaca tctcagcata actgagtttc 2041681 gtaacagtat gaaggttctc gaagcaaatg gagcagaaag cccggcatat gagatgaatt 2041741 aacgtccggc cccctataaa aacgaaaaga agacagcctt ttaccggctg tcttctcttg 2041801 caatttcatc ctttactgcg tgcaatgtat aaaggactga ctcagtgatg tccttgaatc 2041861 gttttttatg aatatgatga acataagatt gaaggaccaa ttccaggaaa ttatccttta 2041921 cggcctcaat ttgctcttta tgcacatatt ttggccggcg gacttttatc aattcaagag 2041981 caccctctgc ccagcgagca gccagttcat cattctcttc aactgcaggc tttatcgtct 2042041 caaaaaaatc ataagaatga ttactgtttt ttccttcctg ataccgatca gcgccttttt 2042101 cagcaacttc aatcatttgc tcggtcattt ccagcaaagt ttgtgatagc aatatctttc 2042161 acctcaatgc ctatcgtacc aaatttcact cacaaattca gccgatgcgg tataccttct 2042221 caaacgcata cctgtgttca ggcgattgat acagctcatt tatacaaata tgaagatcta 2042281 tgatttcttc ttcgagcaca cttaggcgat cgttctccgt ttcccgcatc tcagcctcta 2042341 atgcatttac agaatgattc aggctttgct cagctcgcgt taattcatct tctatatcag 2042401 aaagcatacg gagaatatct gtcttgcata cataaccgga cattcgtgta cctccctttc 2042461 cttgtctctc ccggttaaca ttctttgctc tcaaggctct ttccttcctc atgacaaaac 2042521 tagaagcaaa tcgccaaaca aacaggtatt ccacgaaaag ctgaagtttt cgacaaaaac 2042581 acccgcaaaa attgtatgat cctcctcatt aatgcaaacg atacttgtga ggaggtgccg 2042641 tatgaaaaca agaccgaaaa aagccggcca gcaaaaaaag actgaatcaa aggcaatcga 2042701 ttctttagat aaaaaattag gcggcccgaa ccgcccttct acgtaagaag caaggaattt 2042761 ccttgcttct ttattttttc agccactgct ccaccgcaaa aagcgcatga agctggcgct 2042821 ttttatgtaa ataccagtct gtcaattcaa tctgcttcgg caattcctcg cgcctaaaga 2042881 acgttttctt tatctttcca tgaaaccaat ctgttttcgt tccgtctaat gagtggatta 2042941 actcagggta gcatgtcctt agcataggag atgttctttt tgtaatcccg atcatctttt 2043001 ccatatcaaa acgggaacct gtgtgcggca ctgtgtgcaa aaagtgataa aaagaggaga 2043061 acaattctgg cttgaacagc aattgagaca gctgctttcc cagccttatc ctttcctccg 2043121 cctttgaaaa gcgtttcact gaaatgccgt aaaaaaaccc atttgaggaa ggaaaaataa 2043181 cggtgttaaa atgaaaccag tcacttaaat aaaaaggaat cgtgtcaaaa acattctttt 2043241 taaacgaagg attttgtata ataggtgttt ggatagtgtt ttgttcattt ataatgaggg 2043301 catacattag ccgctccgta tttcgctcat gccaaaaacg ggtccattct tccgacataa 2043361 attgtgagac gccaaacaca tgcagcagat gaaacagcgg tttcccaact ctttttgacc 2043421 agtggtataa aagaagctgc ggataggcat ccgaaaaaat aagccagttc gctctttcat 2043481 aggctaaaaa gaaccatttt tgctgtctct cacggagtcc aagctgaaac agactgcctt 2043541 ttaagtcagt cattgaccag ccggcattac gagaaacgaa agaagccaaa agcgaccatt 2043601 tgatttccgg atgacggtcg taaaatgctt tataagcatt tgttcttgaa atgttatccg 2043661 cgtttttcat ttttgtctgc cgctcaatcc ggctcagaag ctttctgatg gcctgttgtt 2043721 cttgcacgtt cattcacttc cgtcatgatt agtttaataa ggaggatgag aaagtgattc 2043781 ggtatcctaa tggaaaaaca tttcagccga aacattcggt ttcatcccaa aacagtcaga 2043841 aaagggcccc gtcttacagt aatcgcggaa tgaccctcga agatgactta aacgaaacga 2043901 ataagtatta tctgacaaac caaattgccg ttatacacaa aaagccgaca cctgttcaaa 2043961 ttgtaaatgt ccattatcca aaaagaagtg ccgcagtgat taaagaagct tactttaaac 2044021 aatcatcgac aacagactac aatgggattt acaaagggcg gtatattgat tttgaggcga 2044081 aagaaacgaa aaacaagacc tctttccccc tgcagaattt tcatgaccat caaatcgagc 2044141 atatgaagca ggtaaaggct caagacggta tttgttttgt tattatatcc gctttcgacc 2044201 aggtttattt tttggaagcc gataagctgt tttatttctg ggacagaaaa gaaaaaaacg 2044261 gcagaaaatc aattcgaaaa gatgagttgg aagaaacagc ttatccgatt tctcttggat 2044321 acgcacccag aattgattat attagtatta ttgaacagct ttatttttcg ccatcatctg 2044381 gtgcgaaagg ttgattaacg aaaggttgag atgttatgtc agatcaattt aacagccgtg 2044441 aagctcgacg aaaagcgaac agcaaatcga gtccttcacc gaaaaaaggc aagaaacgaa 2044501 aaaagggcgg attgtttaaa aagacccttt tcactttact cattctgttt gttttaggcg 2044561 tagtcggcgg tgctgttaca tttgccgtca tggtttctga tgcgccgtcc cttgatgaaa 2044621 gcaaattgaa gacgccttat tcatcaacga tttatgataa aaatggaaaa gagatcgccg 2044681 aagtcggcgc cgaaaaacgg acctacgtct cgatagatga aattcccgat gttgtaaaag 2044741 aagcctttat cgcgacagaa gacgctcgtt tttatgagca ccacgggatt gaccctgtcc 2044801 gtatcggcgg tgcattagtt gccaacttta aagacggctt cggggctgaa ggcggaagta 2044861 cgatcaccca gcaggtcgtc aaaaactccc ttctttcaca tcagaagacg ttgaaacgga 2044921 aggtgcagga agtatggctt tcgattcagc tggagcgcaa ttactctaaa gatgaaattt 2044981 tagaaatgta tttaaaccgg atttattttt ctcctagagc atacggaatc ggaaaagcgg 2045041 cggaagaatt tttcggcgtt actgatttaa gcaaattgac tgtcgaacag gctgcgacgc 2045101 ttgcaggaat gccgcagagc ccaacagcgt acaacccggt caaaaacccg gataaagcgg 2045161 aaaaacgacg gaacatcgta ctcagtctga tgaaaaagca aggatttatt tctgattctc 2045221 aatataacaa agcgaaaaaa gtggcagtga aagacgaagg cgtcgtgtca cagaaggaat 2045281 atgaaaaagc aagtacaaac aaatacagcg catttgttga agaggttatg aaggaaattg 2045341 atgaaaaatc tgatgtcgat ccatctgctg acggattaaa gatctatacg acattagata 2045401 caaaagcaca agataaacta gatgaattaa tggacggaga caccgtcgga tttactgaag 2045461 gcatgcaggg cggtgtgacg cttctcgata ccaaaaacgg agaagtccga gcgattggtg 2045521 cgggacgcaa tcagcctgtc ggaggcttta actatgctac tcaaactaag gcacagcctg 2045581 gttcgaccat aaaaccgatt ttggactacg gaccagttat tgaaaataag aaatggtcca 2045641 catacgaaca aattgatgac tcagcttata cgtattctaa cggaaaaccg attcgtgatt 2045701 gggaccgcaa atatctaggg cctatctcaa tgcgttacgc tctggcccaa tcaagaaata 2045761 tacctgcttt aaaagcattc caggcagtcg gtaaagatac tgctgtagac tttgcaaatg 2045821 gactcgggct tggtttaaca aaagataatg taacagaggc ctattctatt ggcggtttcg 2045881 gtgggaacga tggtgtttct cctctgacaa tggcaggtgc atacagcgcg tttggaaata 2045941 acggaacgta taatgaaccg cattttgtaa aatctatcga atttaacgat ggcacgaagc 2046001 ttgacttaac accaaaatca aaatcagcca tgagtgatta tactgcgttt atgattacag 2046061 atatgctgaa aacagctgtg aagacaggta ctggacagct tgcacaagta cctggtgtag 2046121 aagttgcagg aaaaacagga acgactaact ttgatgataa tgaagtcaaa aggtacaata 2046181 tcgctagcgg tggcgcccga gattcttggt tcgttggcta cacaccgcaa tatacagctg 2046241 ccgtctggac gggaatggga gaaaacgagg ctggaaagaa atcactttca gctgaagagc 2046301 aaaaagttgc aaagcgcatc ttcgcccagc tcatcgccga tgtcgatgac ggaagcggat 2046361 catttgagaa gcctgacagc gtagtggaag ccaccgtaga aaaaggttct aatccggcaa 2046421 aactggcagg gccaaatacg ccaagcgata agaagctcac agagtacttt gttaaaggca 2046481 cagctccttc tactgtttct aaaacatatg agaaagaaga aaaagaggaa acagctaaac 2046541 tgtctggttt aaacgtgaaa tacgataaag acaatcaatc tttaacgtta agctggaatt 2046601 acgacggaga tgcgaccttt gctgttaagc aatctgttga cggcggcagc tactcggaaa 2046661 ttcaaaacag ctctgcaaaa gaggcagtta tttcgggtgt gcagccagga tctgtataca 2046721 aattcgaagt aacagccgtc agtgatgatg gcaaaagtac agcttccaca tcttatgagg 2046781 tgccaaaagc tgaagacgat gaagataaaa aagaccagca acaaacggat gatgaaaaac 2046841 aagatgatga gaagactcag gatgatacac aaactgatga ttctcaaaaa gatgacggtc 2046901 agacggatca agatcagaca gatgattcaa caaacgatca agacaaaaaa caagacaata 2046961 cgaacaccaa tccgtccgac aacaataacc aagaccaatc aaacgataat gataacgaca 2047021 acagtaacaa ccaggatacg tcggatggtg attcgaactc tggtaagaat gattcaacag 2047081 gttctgacac gaataaaaat aaaacagaca catctaataa aacacaaaca aactcatcat 2047141 ccattgaaaa aacaaattaa acaaaaaagc cgtcaccttt ggggtgatgg cttttttggt 2047201 acacaataaa aaacctcccg ttttaacagg aggttttatc gattcatcgc atgatattta 2047261 taaaaatgct ttttcatttc ggtaatcagc tcatcaagct gaataaagca atggtattgg 2047321 gtcggcttaa gaagaataaa ttccactcgt tcagcccaat taatcggctt tgcgggatat 2047381 gatttctccc tcagttcttg ccaatcgagc gatttcaccg gctcacctgc tgtccaatgt 2047441 aacgaagcca gcaaacacac aatgcccttt aacatttcgt tttggtcaca tctcgatttt 2047501 cgtgtttgaa agactgggag aagtgatgct ttgatgtcat cccacacttc aaataaaagc 2047561 ggaacgtatt tcccgctgtc ctcccatggc aaatcgcctt gtaattccgt gcagaaatca 2047621 aaatacacgg gattggtctg caaggttttc ttcatatccg aggaactctt ctggccaaga 2047681 ctgcgcaagt attgctcata ggaagccaac acttcttttg cttgcgtcat cgtttcacca 2047741 gtcctttttt atccctcttc tgcccttctc tgcacaaaga aagcagcgga cactccgcac 2047801 agcgcggaga ttgggcttta cagtgatatc tgccgaagaa aataagccgg tgatgcgtaa 2047861 cggaccaatc ttctttggga accttgcgca tcagcgtctt ttcaacttcc agaaccgagt 2047921 ccttccaccg gcaaatgccc aatcgtttgc tgactctctc cacatgggta tctacggcta 2047981 tggccggcac gccaaacgca acggatacca ctacgtttgc ggtctttctc ccgacccctg 2048041 gcagtttgac aagctcatcg cggtctctcg gcacttctcc gccgtaatct tcaataatca 2048101 ttttactcag cttttgaata tttttcgctt tattacgata taaaccgatt gatttaatat 2048161 cctgctgaag ctcttccagc ggaacagcca aatagtcttc cggccgttta tatttttgga 2048221 ataatgtttt ggtcactctg tttacaagtg catctgtaca ttgcgcagat aaagcaacag 2048281 ccaccactaa ttcaaaagga ttggaatgaa ccagttcaca ctccgcatga ggaaacatgt 2048341 cacctatctt gtctaaacag aattcaattt gttttagatt taacacgatt gtcacctttt 2048401 cactttattg ttcaagccaa ttgtaaaaag gaacctgcct tttatactct ttttgcggtt 2048461 cattctgctt tgcttgtaca cgccggaatt tttggctgtg tatttttgcc tgctccacag 2048521 ttttaagccc atttttcttc cattcaaaca aaatccggtc aatgtagcgg aaactgagtt 2048581 ttcctgatag tacagcctct tttaacgcgt gtttgatcag ttgtgcgtca tgctgatcct 2048641 ggtcctgcca gatcgccagc gtttcacact ccaaaggcga taacggtctt gcgaactctt 2048701 cctcaaaaat ggtataaagg cttttttgtt ccccttctgc ttttctttcc tgtgtttgat 2048761 tctgtgcaag ctgaatatac tcgtacagct tgccccataa aggctgaaga gaatatttct 2048821 caaatttgat gccgttttga tcctcgcatt cttcaataaa cagaaagcct ttttgaataa 2048881 acatccgcaa tctgtttgta cattcttcaa cagaaattga cataccttcc tgcagctgat 2048941 tcggtgtagg aaaatatgat cctttttcta aatgcatttt aatttttaac agcagaataa 2049001 gttctgtttc attaagccca agctgtttat aatgcgtgag cagaagattg gggatggttg 2049061 atgttccctg ctcctgcata tcaataaatt gctgtttttt catcgtcaca cctcttactg 2049121 taaaggattg tgattgcccc tttactgtaa aaagtctccc ttgcaggaga ctcttttttg 2049181 tttcatttga atgtattacg gatacagacg gtttaacagt cttgggaacg gaatcgtttc 2049241 acgaacgtga ggcgctccgc tgatccaagc tactgtccgc tctaatccaa ggccgaagcc 2049301 ggaatgagga actgatccat attttctaag ttcagcatac catttataag cgtcagaatc 2049361 cagtccatgt tctttaagac gcgattccaa aagttccata tcgtgaatcc gttcagaccc 2049421 gccgatgatt tctccatagc cttccggcgc aatcaagtca gcgcaaagca caacgtcctc 2049481 acggtcagaa gccggctgca tatagaacgg ttttaaggac gtcggatagc gagtgatgaa 2049541 taccggtttg tcataatgtt cagcaatcgc tgtttcatga ggcgctccga aatcatctcc 2049601 ccactcgata tcgtcaaagc ctttttcttt cagaaattca atcgcttcat catacgtaat 2049661 tcttgggaac ggggctttga tttgctcaag ttttgacgtg tctcttccca atgtgtttag 2049721 ttcaattttg caatttttaa gaactgattg cacgatgaaa gaaacgtaat tttcctgtac 2049781 ttgaaggttt tcttcaaatt ctacaaacgc catttccggt tcgatcatcc agaattcgat 2049841 taagtgacgc tttgttttag acttttccgc tctgaatgtc ggtccgaaag agaatacttt 2049901 tcctaaagcc attgccgcag cttccatgta gagctgtccg ctttgagaca gatatgcatc 2049961 ttcatcaaag tactttgtcg caaagagttc tgttgttcct tcaggtgcgc ttccagtcaa 2050021 aatcggcgga tccactttta cgaagccttc gttattaaag aattcgtaag tcgcgcgaat 2050081 gatttcatta cggattttca tgatcgcatg ctggcgcttt gaacgcagcc ataaatgtct 2050141 gtgatccatc aaaaattccg ttccgtgttc ttttggtgta attggataat cggtcgcttc 2050201 gtgaatgact tcaatatctg tcacagcaag ttcatatcca agcggagaac gctcgtcctc 2050261 tttgacaatc ccttttatat agagcgacgt ttcctgcgtc actgatttag ctgtttggaa 2050321 aatgctttct tccacttccg cttttactac gacaccctga ataaaaccgg taccgtcccg 2050381 aagctgtaaa aacgcaattt tcccgcttga acgcttatta gcgacccaag ctccgatcgt 2050441 tacttcctca cctacgtgct tgtacacttg gttgattgtt gttttcaaca tatttccctc 2050501 caaaacaaga aagacattcg gaagctcatt gccccgcgaa ctcttttatc atcactttat 2050561 tatacccgct cttaactaac cgggtcaatg cagataaaaa gcggcttttc tgtcagccgc 2050621 tttttgatct gttagctatg tttttctaca aaacgcttga ttctttcaat ggcttcttca 2050681 agaagatcta acgatgttgc ataagaaaga cggacattct caggagagcc aaatccggat 2050741 cctggaacaa tcgcaacttt ttcctcctcg agaagcgctt taacaaattc atctacatct 2050801 ttgaaaccgc aagattgagc tgcctctttt gcatttggga acaagtaaaa agcaccttcc 2050861 ggcttcacgc agctgaaccc tgggatttct atgagctttg catagatcgt atttaatcta 2050921 tgttcaaatg cttctctcat ttcttccaat ggctcagaag gcccgttata agcagcaatc 2050981 gctccgtatt gtgcgattga tgtcgggttt gacgtgctgt ggcttgcaag gttcgtcatc 2051041 gctttaataa tgtcttcaga gcctgccgca taaccgattc tccagcctgt catgctgtgg 2051101 gacttcgata cgccgtttat aatgaccgtt tgctctttca gtctgtctga cagctgtgca 2051161 atggaaacat gtttctttcc gccgtatgta agtttttcat aaatttcatc tgacacaatc 2051221 aagatatcat gttcaaggca cacttcaccg agcgcagata gttcttcttc cgtatacatg 2051281 acaccagtcg ggttgcttgg agagttaata acgattgctt ttgttttttc cgtaattgca 2051341 tttttcagct gctcaggcga aattttgaag tgattttcct caagcccttc tacataaaca 2051401 ggctttccgc cagcgagttt cacctgctcc gggtagctta cccagtaagg cgttggaata 2051461 ataacttcat cttcttcatc caaaatcact tggaaaaggg tatacagagc atgtttggca 2051521 ccagtgcaga caataatttg agacggtttg tattcaatat tctggtcgcg tttaaatttc 2051581 tctgcaatgc tgtttttcag ttcagccaaa ccaccggaag gcgtgtattt cgtatggccc 2051641 tcgttcatcg aacgcacagc ggcatcaata atatgctgcg gtgtattgaa gtcaggctcg 2051701 cctgctccta agccgatgac atcatggcct gcggctttca gttctttcgc tttcgctgtg 2051761 attgccagtg tggttgatgg tgttaatgcg gatactcttt ttgccagttt caacttgaac 2051821 tccccctaat tcgtcttaag gcgtgatatt tttgagaatc tttccagttg taaagtccac 2051881 ataacttaaa ctgtattgcc cttctttgtc taagtacgtc acttcccaaa gcaggacgtt 2051941 tccttctctt gccagatgaa cctctttttg ctttgaaacc agcccttcat cctttatgat 2052001 tttcgccgct ttgtcttcag agattccctc tttcgcttct tttgagagaa tttttgcttt 2052061 tttatcagca ggaacccaga catataatgc agtgcctttt ttatccgttc cctttacaac 2052121 ataatatttt tcttttccga caaatgtttc gacttgatca acatgggcga gatcggtttc 2052181 ttttttagct tcagcagctg ctgcttcgtg cccctcttcc ttttgtgcca tggctgattt 2052241 ataaatgctt gccgagacaa gaagtactgc taaaaaaata ataccaaaaa tgacggtaaa 2052301 tattaatgct ttttttctca tcttctcacc tacgtacgat aaatggtaaa aacggcttgg 2052361 tttttgtttt cttcatccag cgcaaggccg aacatcagat tgtctctttt cagtgtacga 2052421 ttcaatgtgt ccacaatttt atacagatca tcagaatgct ctacattaat tgttgaaaga 2052481 atttcgattt tactttccat tttttcatcc tccagtttga acaaatattg ttagtcatac 2052541 tccatttcag gacacgccat actagtatca cagagcggga aatccgcttt taaataaaac 2052601 accatcctac tcccacaccg caaaagccgc tttatgcggc ttttattctt tttcccctgc 2052661 aacataagct tcaagctcgc tgtcagtcat ttcggatact gaggttgtcg gcaaggcatc 2052721 aagaaacagc cggccgtaac cagcggtttt aatccgtctg tccaatataa taatcgttcc 2052781 cttgtctccc gcagaacgca gcaagcgtcc gattccttgc ctgaaggtca gcacagcttc 2052841 cggtaatgac actgtttgaa acggattctt tccttttttg cgggcaagct cacattttgc 2052901 agcatgaagc gggtgatcag gggaccggaa tgggagcctc acgatcatta ctgtcgtcag 2052961 ctcatcacca gggaaatcaa cgccttccca aaaatgattt gttccgagca ggatcgcctg 2053021 attggatgtt ttaaaagtct tcatcagttt gccgggactt ccgcctgtaa tcccttgtgc 2053081 caagagctga atgccggaag cactcatgtt atgcttaagc tcctggtgaa cctttttcag 2053141 catatcatgg gatgtaaaca gcacaaggat tttaggctgt ttttcctttg ccatcagttc 2053201 gatataacgg gctgtatcct gtataaattc aggttgccct gtatcctgaa ttgatttcat 2053261 ttcttttgga atcatcacct gcatacgctc atcgtaagaa aagggtgact caattctcat 2053321 tgtccgcggg aaaaagtcac tcagtcccag tcgttcaatc ataaattgaa aagaaccttc 2053381 gactgtaaga gttgcagatg tcagcaccac actatttttg cgcgcgaaaa actgatcagc 2053441 cagaagttca ccaggttcaa gaggctgtgc gtaaatggcc actgcatttt tcgcaccctt 2053501 tgcatctatt tcaatccaaa ccgcttcatc gtcatcagag ccaaagaaga gcttctgcaa 2053561 cgtctgacag taatgctgca agcctttcat gcttctttgg tattcatcgg ctaaaaagac 2053621 ggttttgctc ttcatgccct tcaaatgttt ttccataagg gatgactgcg cctcaaaaag 2053681 ctgctgcaaa tgtgtcagca tggaacaaag cctctccgca ccatctgtta agatcgacca 2053741 gcttttatcc tggctttctt tgttcacctt aaacactaga cggtttaagt cttctttagg 2053801 ttttcttcgt ttgacaaaag aatgtacaga gctaaagaaa gcatcacttt ctgcttgaac 2053861 gtgctgaagc cactcttcca attcgaaaaa tgaatcaacc ggcaggctgt ttcgctggaa 2053921 tagctgtctc atctttttta gaagtccctg ctccttcaga gtgccgattc tgctcaattt 2053981 cgtatgcaat tctatgtacg tggctctttt ccctaaatgt tcgcttgccg cacgttcaaa 2054041 atggtgtgct tcatcaataa taaatgtgcc gctttcggga agcctttttt tatggctgcc 2054101 ttcatcggtc agcaaaagag aatgattggt gatcaccaaa tcggaacgca tagcaatctg 2054161 tttggcccgc tcgtaaaaac cgatcacatg ctcactgcga cttcttttat aggagtcatc 2054221 gtcataagcc aatctgtccc acagcaattt tccgcctgaa ggcaaattca gttccgctac 2054281 atctcctgta tttgtctctg tcagccaaac aagaagctgt gcctttgtca gtacggcatc 2054341 ataattatca tcttcttcat gaagcacctg ctcaaattta tacaggcata aataatgcga 2054401 ttgccctttt aaaatcgccg ctgttaccgg aaatggaaac agatcttgga caatcggcaa 2054461 atcctttgtg agaatctgct gctgtaaaag cgtcgaatac gtgctgatta tgaccggctt 2054521 ttttgatttc ttggcaaaaa gcgcagccgg aataagatag ccaatcgttt ttccgatgcc 2054581 tggaggagct tcaatcagcg catgctcacg attggcaaac gcatcagcca cctctctcat 2054641 catcatcatt tggccgtctc ttttttcata cccaggcatt aactctgaca gcgctttttc 2054701 atttcccgct tcccagcttt cgatctcaaa tgagaagttc tcgtcctcat ttatacgaac 2054761 atcgatagct tcaggttctc tgacagaaaa cgaagaaaag cgcgtatagc ccggtatctc 2054821 ggtatgtctg ttttcattaa tgaacatatc caacaaatgc gtcagatcac tgatgaaatg 2054881 ctgcgaaagc cttcttaact gctttaatgt cggataagga agctgccgca gcttttcaag 2054941 gatttccaaa aaaataagcc ctgtcacttc agcatcgctg tcagcccggt gcggctgatc 2055001 atgccgcagc tgaagctcct cgcttaattc cgtcagctta tacccttcaa atcccggaaa 2055061 aacaatgcgt gagagctcga cagtatcaag cacttcacaa tctgggagct gaaagcccgc 2055121 cttatgtagc tcatacttga caaatccaag gtcaaaatgg atattgtggg cgacaaaata 2055181 agcgccgtca agcaattgga atacttcttc agcaactgct tcaaatggct gttcattctc 2055241 gaccatttga ttagagattc cagtaagctg ctcaataaaa gcagggattg atttatttgg 2055301 attaatgtat tttgaaaacc gctcagtaat ttgtccattt tcgattacaa ccgctgcgat 2055361 ttgtatgatt ttatcgcctt tcttcggcga attccctgtt gtctctacat ctataacaac 2055421 gaaccgttgc ttattcatta aaatggacac ctcaattctt gcatacgaca aaagtgtaac 2055481 acgttttgta cggaaatgga gcggcaaaac cgttttactc tcaaaatctt aaaagaaaac 2055541 ccccgataaa gggggctttt cttctacaaa attgtacggg ctggttcgtt ccccagcatt 2055601 tgttcaattt tgttttgatc attcagaaca gccactttcg gctcatggct tgccgcttct 2055661 tgatcagaca tcattttgta ggaaataata atgaccttat ctccttcctg cacaaggcgt 2055721 gcggctgcac cgtttaagca tatgacgccg cttccccgtt taccaggaat aatatacgtt 2055781 tcaagacgtg ctccattatt attattcaca atttgtactt tttcattagg aagcattccc 2055841 acagcatcaa tgagatcttc atcaattgta atgcttccca catagttcag gtttgcttcc 2055901 gtaacagttg ccctgtgaag tttgccgctc atcattgttc gatacatatt atattctctc 2055961 catttctcga atatcaataa tgatattatc tattaaacgc gcttttgaaa aagcaactgc 2056021 aacagcgaga atcatctttc cagcaatttc attcacaggc tcgagttccg gataggaata 2056081 aagctctaca tagtctatgg ttccgctagt cgtttcaatg atatcttttg cagcttttat 2056141 caccgcttca ggatctcttt caccggcttg gacaagttcc gcacttgttt gaagggcccg 2056201 atacagctta ggcgcttctt ttctttcctc agctgttaag tatacattgc gagagctttt 2056261 ggctaagccg tcttcctctc tgaccgtatc gacaggaacc aattcaatat ccatgaagaa 2056321 gtcgctgatt aacccatcaa caacagctac ctgctgcgca tcttttaaac cgaaataggc 2056381 acgagtcggc ttgactagat tgaaaagctt cgtcagtacg atcgcgaccc cgtcaaaatg 2056441 tccttctctt gagcgcccgc ataacacgtc tgtgcgtctt tctacatgaa tcgtgacatt 2056501 cttttcaccg ggatacatat catgagcatc tggcgtaaaa agaatatcga ctccggcgtt 2056561 ttctgcaaga gctgcatccc gctcaatatc gcgcggatat gcttcaaaat cttcattagg 2056621 gccgaattgt gcaggattca caaaaatact cataataacg gcgtcgtttt cttgtcttgc 2056681 tttgtctgct aaggttaaat gcccctcatg cagaaacccc atcgtcggaa caaatccgat 2056741 tgacttgccc tctgaatggt attgttttat ggcttctttc agctgtgaaa tatcagtaat 2056801 ctgtctcatc ttattttccc ccgtacaagc cgtcaagcac tgtctggttc atttgaaagg 2056861 aatgcttttg ttcagggaaa gcacgatgtc ttacatcctg aacatatccg ctgattgctg 2056921 tttcgatggt ttcatcaatg cgcgtatatt gctttacaaa tttaggtgtt ctctcaacac 2056981 cgtggccgat aatatcatga taaacgagaa cttgtccgtc cgctttcaca ccagccccga 2057041 ttccaatgac cggtatgctt agcgtctcgg caattttggc tgtgagttct gccggcacac 2057101 attccagcac aagcatcata gctcctgctt cttcgcattt tatactgtct tctattaatt 2057161 ttttggcgct ttgttcgtct ttgccctgta ctttatagcc gcccagtacg ccgactgact 2057221 gcggtgtcaa acctaagtga ctgactactg gaatgcctcc aagcgtcaat gcgcgaatgg 2057281 attcaaacac gccttctccg ccctcaagct tcagtgcgtc agctccgctt tcctgaacga 2057341 tagccgctgc atttttcagc gtatcttcct tagacaggtg ataagacata aacggcatat 2057401 ctgtcacaat aaaggtattc ggcgcacccc ttttaacggc ttttgtatga tggatcatgt 2057461 ccgcaactgt cacaccgaca gttgaatcaa ggccgaggac gaccattcca agtgaatcac 2057521 cgactaaaat catgtcaact cccgcttgtt cagcaagttt agctgccgga taatcataag 2057581 cggtcagcat gacaatcggt tcttcagact ccttcatttt tagaaaatcc agttttgttt 2057641 tcatgttttc tcctcctcat gtttagagga gatgatctgc cgttttcttc tgcaagccaa 2057701 aaaaccttcc gttacaacga gaaggattct tcactttcta aagttcggcg agtttcatcc 2057761 ctctgtccca gtcctttttt ggatcaaggc agactgctgc aatgtctatc tattttaata 2057821 ataggtgcag ttcgcaggcg atactgccca atggaagtat accaaaatca acgggcttgt 2057881 accaacacat tagcccaatt cgatatcggc agaatagatt tttttaatgc cttcgttcgt 2057941 ttctaaaagc agaacgcctt catcatctat acctaacgcc ttaccgtaaa aggttccgtt 2058001 taacgttctg gctctcatat tagtgccaat accgagcgca tagctttccc ataaaagctt 2058061 aatcggcgta aatccgtgcg tcatataatc ccggtaccgt ttctcaaagc atagtaaaat 2058121 atgctggatg acgccggccc gatcaatttt ttccccagca gcttggctga ggcttgtcgc 2058181 gatgtccttc aattcatctg gaaaatcatt aggctgctgg ttaacgttaa tgccgatccc 2058241 aatgatcact gaacgtacgc ggtcttcttc agcctgcatt tccgttagga taccgactgt 2058301 tttttttccg ttaatcaaaa tatcatttgg ccatttaata tccgtttgga tgcctgctgc 2058361 ctcttctatt ccctgcacaa cagctactgc agcaagcaga gtcagctgcg gtgttttttg 2058421 gagcggaatg tcaggccgca aaatcaggct catccaaaca ccgtttcctt cttgagaatg 2058481 ccatacccta gacattcggc cccttccggc tgtttgtttg tcagccacca caagggtgcc 2058541 ttccggtgcg ttattattcg cgagctcatg agccgttttt tgcgtgcttg aaagaacgtc 2058601 atggtaaata agatgctggc ccatcacttc cgtttttaat ccaaaacgaa tttcgctttc 2058661 actgagtttt ccgggttttt tgatgagccg atatcctttt cttctaacgg cttctacttc 2058721 ataaccctct ttccgaagct cttcaatatg cttccacaca gcagttcttg aacagccgag 2058781 agcatcactg attttttggc cggaaataaa ttcattgccg gcctgagaaa ataattcaat 2058841 aaggtctttt cttaatgttg accgcatgtc ttcagccact cctctatgtg tttcttttga 2058901 ttggagagct tccctgtcac aacagcctgc tcgatccact gtaattcttc tgacacccat 2058961 tttccggccg gccggtttcg aagcgcaagc aagtccttac ccgtgatatc aagatcctta 2059021 aggcttttga tcggcaggtt ttgataagcg tactgaatgt ccttcagttt cttttcatcc 2059081 agtttttcgt tttgccgaag ctgcgatatt ttggccgctg agagcagtgc ttttttccca 2059141 gctctgtaca ttgtcattgc gtcaaggctc tggccaaacg tatcggcaat gtgaatggct 2059201 tccttgatca cttttcccgg gagcttccag gctttcagga aaaggggcgc gtctttcaaa 2059261 actatgccaa ggttaattaa aagagcagcc caaagctcct cacgggatgt taaagagaag 2059321 aatggaaact cactcgttga aatcaggttt tctcgtttat gataaaaacc aggaagctct 2059381 tcatacaatc tcgtttgaat gagtgtttga agcgcctggc gagaagctct tccctgcagc 2059441 aatttctcaa actctatagt ttttcgttcg actgaaacat gggagaggag tgatttttct 2059501 ttcgcaatgg cttcttctgt ttccggtgaa agcgtaaagc caagctggct cataaagcgt 2059561 acggctctca gcatacgaag cgcatcctct tgaaatctat cctcaggctt tccaacggtt 2059621 cgaatcactt tctgatcaat atctttcttg ccgccaaaat aatcaagcac cttcccgtcc 2059681 gctgtcatgg ccatcgcatt gatcgttaaa tctctgcgtt ttagatcctc ttctaatgat 2059741 gagataaatt gcacttctga cggtcttctg aaatcaacat aatcagattc agtccggaat 2059801 gtcgtgactt cataggtttc atcctcccag agcacaataa tggtcccgtg ctctttgcct 2059861 acatcaacag tccgctgaaa cagccgttct acttgatcag gtgccgcatc tgtcgcgata 2059921 tcgacatctc cgatcgttcg tttcatatag ctgtcacgaa ctgcgccccc gacaaaataa 2059981 gcctgatggc ccgcttcgat taagatgcgg agcacgggaa gtgctttgat aaaaactttt 2060041 tccatgtgat cactccggtt ctgctaaatc ggcataaatc tgttcatact ggctgacaat 2060101 ttttttagaa gaaaattcat tttcaagcat ctctattgcc gcctttgtaa aacgattgct 2060161 tagctgttca tcttctaaaa tgctcatcgc gcgggctgtt gcggccgtaa catcaccgac 2060221 atccaccaaa aatccgctca cattgttttt tataacctca gggataccgc caatgtttgt 2060281 tccaatacaa ggcactccgc aagccatcgc ttcaagcagg acaaggccaa agctttcttt 2060341 ttcagatagc agcagcttca aatcgctaat agaataaaga tcttcaacac ggtcttgatt 2060401 tccaagcatt aagacttggt cttccaagcc atattttctg ataagctcgc aggctgtcga 2060461 tttctccgga ccgtctccga ctaaaagcag cttcgctttc gttttgccag cgatattgcg 2060521 gaacacacgg atgacatcct gcacgcgttt aacttttctg aagttggaca catggatgac 2060581 gactttttca tctggtaaaa ttccatgttt ctctttaatt gccgctgtgt ttttcttcag 2060641 atacacgcgc tcgtctataa agttataaat cgtttcaatt tttttctccg gtttaattaa 2060701 atcgtatgtt tcagccgcaa gcgctgagga gacggccgtc accctgtctg atgactcaat 2060761 agcaaaacgg atcagatctt ttagagacgg atcataacct aacaccgtga tatccgtgcc 2060821 atgcaaagtg gtaacaatgc cgatattgcg tttcagcatt tgttttgcaa gataggcgca 2060881 aacggcatgc gggagagcat agtgagcatg gataatgtct aaattctccc gttccgccac 2060941 ctcagcgatt ttgcttgcca atgtcaaatc atacggagga tacttaaaaa cagcatattg 2061001 attaacctca acttcatgaa aatgaatatt gggatgatat gtattcagtc taaacggaat 2061061 gcttgatgtg atgaaatgga tttcatgtcc cttttcagca agctgcttcc ccagttctgt 2061121 cgcaatgata cctgagcctc caacgctcgg atagcatgtg attcctattt ttagttttct 2061181 cattgttcgc ccccaagcac atcatgatca agcatcagca tccgtttgga aaagaaacct 2061241 tcggcatact ccacgcccgc ttctttaccg taaagctttt ctctcgcttc aacgatttca 2061301 atatacccat tcgtcagagg agtagaaacg gaatcctttg acgggataaa ctggcttttg 2061361 taggcgttga ggctttgttt ctttgcctct attgtatccg agatatcaat aacaaaatcc 2061421 ggctgatgaa aaccatttat catataatag taaaccttgc tgactttatg cgccggaagg 2061481 cttttttcgt ctttatattt atggattccg gcggaaaaga tcgcttcttc caccagtgca 2061541 gccgcattgc cgtgatccgg atggcgatcc tttttatacg gcataaaaac cgcttttggc 2061601 cgacagattc tgatgacagt gacaattgac cgaattgcct gatcactcat tattaggccg 2061661 cggtctggaa gcgttagctg aattctttta tctgcgccta atatgcgggc tgcttcagct 2061721 gcttcttctt tacgcaaact gaccgtaccg ttagaagaga gttccgcttc tgtcaaatcg 2061781 catatcatta cttttttttc ctgtttgaca aacttcgcta ttgtgccgcc cattccgatc 2061841 tcgacatcat cactgtgggc gccaaaagca agaacgtcag cattatacat tcggctcttc 2061901 tccccgaaga aggtcacgga attcgaaaac accttcatca agtgtgcgca caagaatttc 2061961 cgcagtaccc atatttgtgg cgagcggaat ggaatacaca tcacataaac ggattaatgc 2062021 cgagacatcc ggttcatgcg gctgcgcggt cagcgggtcg cgcaaaaaaa tgacaagatc 2062081 gagtgcattg gcagcgatca gtgcaccgat ttgctggtct ccccctaaag ggccggattg 2062141 aaaacgttca atttgaagac ctgtcgcctc atgaattttc aaccctgtgg ttccggttgc 2062201 gtatagatca tgattcttta aaatatcccg ataggcagtc gtaaattgaa ccatatcctg 2062261 ttttttcttg tcatgcgcga tcaaagcaat tttcattgtt tatccccccg tctaatcaat 2062321 gatattttct aaaccataca caagctgatc aatcttcatg acttgttcga ctgacagttt 2062381 aacgcctgac atgaaagaag cacggttata agaatcatgg cgtatctgaa gcgtttggcc 2062441 atccatgccg aacatgacct cctgatgcgc gatcagtccc ggaagacgga cgctgtgcaa 2062501 gcgaataccg ttttgctccg ctcctcttgc tcctgggaga atttcttttt catccggatg 2062561 tccttgctgc ttttctttac ggacttctga aatcatttcc gctgttttaa gcgcagttcc 2062621 gcttggtgcg tcaagcttct ggtcatgatg aagctcaata atctcaacat cctcaaaata 2062681 gttggcagcc atttttgaaa atttcatcat cagtatcgca ccgagcgcaa aatttggcgc 2062741 gatgatggct ccgatccctt tttcttctgt taaagatgtg agctctttta aatcagcttc 2062801 tgagaaaccg gttgttccga caactggacg gactccgtgc tctaatgcaa tttttgtatg 2062861 tacttttccg atttcgggcg ttgttaaatc aatcaagaca tccggttgtg tttctgtaaa 2062921 acaggcatgg atatctgtgt aaatgaaagc atctgactca acaggcatca catcagataa 2062981 tttttgctga tcgtatgtat ggtctatggc ccctacaagg tcaaaatgtg gtgttcgttc 2063041 tgccaattta acagcttcct gccccattct tccacgcggt cccgcaatga ctaatttaat 2063101 tgtttcgttt gacatcttga tctcctctac tttccttctt cttttctggt ccagcgatct 2063161 ttatctcttg tattaaattt atgcatgact cggtcgtgag cttcctctaa agagatatca 2063221 agagagttgg ctaaacaaac caatacaaat agcacatcgc ctatttcctc ttccatgctt 2063281 ttatcatctt cagtcgcttt ttttggtttt tctccataac ggtgattcac ttctctggca 2063341 agctcgccca gttcttcagt cagcctcgcc atcatggcca gcgggctaaa atatccttct 2063401 ttaaattggc ctatgtaacg gtctacttca gcctgtatgt ctttcattgt tttatcactc 2063461 actgaacgaa acctcctatc atcctcttac atgttagcta attcagatac gtttgacaaa 2063521 tgtttaagca cgtttgctgt tttctttttc atccactata atataaacgc tatctaatgg 2063581 aaggaaaagg ggttttgtgt gatgcttgga gaaattagat taaaaaacat attttttatt 2063641 ttaatcggag cggcaatttt ttcatttggc ttggttcatt tcaatatgca gaacaatctg 2063701 gctgagggcg gttttacagg tattacactt ttgctttatg cccttttcca catcagcccc 2063761 tctatatcga acctggtgtt gaacattccg atttttttta ttggctggcg tttgctcggc 2063821 aggacaatgt ttgtttatac ccttgtcggc actgtagcct tgtctttgtt cctcagcatc 2063881 tttcagcgat atgaaatcca tatgcccctt cagcacgact tagcgctcgc cgctttattt 2063941 gccggcgtat tcatcggagc cggactgggt attattttta agttcggcgg tacgacaggc 2064001 ggtgttgata tcatcgcacg tttagtgaat aagtattttg ggattccgat gggcagaacg 2064061 atgtttgctt tcgatgcctg cgtcatcatt ttgtctttgc ttacttatct ctcctataaa 2064121 gaagcgatgt atacgctggt agctgtattt gtagcggcaa gattaatcga ttttattcag 2064181 gaaggcggat acgctgctaa aggcgctacg atcatctctt cgaaaaacga cctgattcag 2064241 aaaaagattc ttgaagaaat ggaacggggc gtcaccattt tgaaaggaca aggttcctac 2064301 acaaaagagg atatagatgt actttattgt gtggtgccga aaaatgaatt ggtgatgctg 2064361 aaaagcgtga ttaactccat tgatccccat gcctttgtag cggtaagcga tgttcacgat 2064421 gtgctcggag aaggatttac gcttgatgaa aataaaaatc cgcttccgcg ctgacatgta 2064481 atagaaaaaa ggcggctgac cgccgcccct catccttatt tagggtagtc cctttttttc 2064541 agcttgtttt tttccgcctt gtactttctg taaccgacat aggtaagagc agtaatgatg 2064601 atactgccgg ttgtaatgat cacccagagt aaagacggat cggcatcatc ctcctccacc 2064661 ctgtcaaaca catttttcag gtcatgctga agaagggaaa gccgttcaag cttcgtgctc 2064721 tctgtcattt gctgaaattc ctcttgctca ataacatcta tatgttttcc gactgtttca 2064781 agctgatcct ctgatacatc gattgtaaga ctggggtaaa tcaagtcata taaactgata 2064841 aattcattcc atttttcatg aaagcttgtg cttccattct tttggacatc tcgcttcagt 2064901 tcagtaaaag cttccataat cggtttttcc agtgagcccc aaagcgggtc agaccgattg 2064961 tcaaccgcat ccatcagcat tctgaactgc gcggctgctc tgagtttttg tgtgtctgat 2065021 gtatcagctt gctttaaact ccgaaccata tcattatagc ccaatgtgat ttgacgaatt 2065081 tgggctcccg ttagcatggg gtcttgctgt tttttctcag cggattttaa tgttttttca 2065141 aaatactcca agacttgaag cgcctcttca tatttcgcct gtcgggtcat ttgaaagact 2065201 gtatcggata aatcattcaa ttcctcgagg cttccccgct ctgcagcctt ggcatttcca 2065261 ttataaaaaa taagtgcaat caacaaacag atcgtcagct ttcgtttcat gcaggtccct 2065321 cccactctct ctccttacag aatatgaaga aagggacaag gatagaccaa cattgtcttt 2065381 acatcagctc aagcttcgtt tgcttttttg agaccacaag aaagtaagca agcgcgattg 2065441 aaaagatact tagccaaaat gttccgtatc ctatttcagt catataatca gaaagcatag 2065501 agtattgcgg catcatatca aacaagtagt caatgacatc gttatgcagt gtccagactg 2065561 cagcaattgc aagatgccaa aatgaaaaac gaaaatacgg actgtataat acgccttgaa 2065621 ctgccattgc aaaatgcgaa gcaattagca tgtagccctc ccacggcaag tcaccagtta 2065681 ctgcaagcac aagaaaattc atagccaccg cccataggcc atactttacg agggtaacta 2065741 gcgcaagcgc ctctaaaagc ggagcattcc gtttcatgag aaaggcaagc agcacaaaca 2065801 gaaagaaaaa cgttgctgtc ggactgtccg gaacaaaaat caggaaacgg gccggtgtct 2065861 ccaaaagctg cggcaagtac caatagtagc cgtaaaccgt tcccagaaaa ttaatggcta 2065921 agacaagaat aagcatcggc cgctgcccta atacatattg aaaccatttc acatcgaatc 2065981 aactctcagt ctgtaaaaat aatatgtcca tataaaaaag ctgacgccgg gtcagctttt 2066041 gataataaaa gtatatcctt ccatttgaca attcacaata cgttattttg cggttgtttc 2066101 agaaataaat tttgcaagtt cttcgagctg cttatcattt cctttgaaca cacccgccgg 2066161 cattttgcct ttcccttcta cagcgatttt tttgatttca tccggtttca gcccgctgtc 2066221 aaccaatgaa ggcccggccg ctcctccctg aaggttatcc ccatggcaag aaatacagcc 2066281 ctgttcctta aaaaccttat atccttctgc attggtgtca atgtcggctt cttttgtaat 2066341 tttcccctgt tcttctgcct tggcccagtc atgagtagca actgactgcc acgtcaaaaa 2066401 tacagcagcg gaaatggcca gaagcatcat accgacagcg accggacgct tccacggcct 2066461 tctttctgtc cctctgtcta ggaatggagc caaaagcagg gccccaaaag cgagacctgg 2066521 cataatcatg gcgccgacca ctgtaaagct tccggcggcg tattcatact tcaacagctg 2066581 gtataagaaa agaaaatacc aatccggcag cggaatataa ccagtatcag tcgggtccgc 2066641 catccgctct aaaggcggct gatgcacaat cgtcaaaacg agaaaaccga tgagaaagac 2066701 agctccaacc atccattcct ttaacaagaa atttggccag aaagcctctg ttttacccgg 2066761 atactccgaa taatccttcg gtatattcgg ctttttttca gccggtatcc ttgagtcgcc 2066821 tacaaatttc atccctttgc cccggtgcat gtcatcccct cccttttatt cgcagatcaa 2066881 gagtttaaag cggtcctgaa atcccctgct tccggatcat aataaaatgt gcagccatca 2066941 gcccgaacaa tgcggcagga agaaaaaata catggatcgc aaaaaaccta gtcagcgttt 2067001 gggcgcctac aatatccgga tgccctgcaa ggagcgtttt aacttgcgtt ccgatcaaag 2067061 gcgtggcttc ggcgatctgc agtccgactt ttgttgcaaa cagagccttc atatcccaag 2067121 gaagcaagta gcctgtaaag ccaagaccga gcataacaaa aaagatcagc acaccgacaa 2067181 tccagttcag ctcgcgcggt tttttatacg cgccttggaa aaagaccctc agcgtatgta 2067241 aaaacatcat cacaatgacc aggctcgcac cccagtggtg catccccctg acaatctggc 2067301 cgaatgccac ttcattttgc aaataatata ccgattccca ggcatttttg atatcaggca 2067361 cataatacat cgttaaaaac attccagata atacttggat aacggttaca aaaaacgtca 2067421 gtcccccaaa gcaatacaca aacgcagaga aatgatgggc gggattcaca tgttccggta 2067481 cttcgtgatc ggcaatatcc ctccacatcg gtgtaatatc aagccgctcg tctacccagt 2067541 cataaatttt gttcagcatg tcacccttcc cccttaggct ttgcttttcc aagatacagg 2067601 aagccgtctt ttacttcttg ctcataatga tcaagaggcg caagcggcgg cgtgccaggg 2067661 acattggtgc cgtccttttc atagagtccg taatggcatg gacaaaagaa tttattcggg 2067721 tttttaggat cactattcca gttcaccgta caccctaaat gcttacaaat tggcgaaagt 2067781 gctacaattt catccccgtt tttgaagacc caggctgatc ttgactcttc tgactcatac 2067841 caggcatcga cttgattaat tttaaaatca aagcgctgcg gctcttttgt caactcatca 2067901 acgctgacaa cctgaaccat atcctgcttc cctgtcgatt ttaataccgg gtcgagtgcg 2067961 aagcgaacca taggcatgag catactagcc gccataaaac ctcctacgcc tgtgagcgta 2068021 taattcaaaa attgacgtct ggatatatca tgttttccgc ccatctcttc tcccccctct 2068081 aagtcacccc tgcaaactga ctaaaataga aaatattgca ataactctag acaccctcat 2068141 aatatatgaa tctctcagca aggtcaatat agccaaaata ttgtttataa ggaaatgtaa 2068201 gtgtttttat aaagtgctcc ataactgtaa caaaacgttc aaaatttcag cagtgcgttc 2068261 atccaatatt tttcttttta aagagtcatt taaatgctct aatggaacag acgatgtaac 2068321 aatcattttg cctaacgcat cctcagctct ccaactttcg tcagatgtga gcaggacaac 2068381 atgcggaaat tccgttatca gctcttcccg caaatcctta agcccttgaa cggttatttc 2068441 atttctatca acatatgtat aaggcggaag taaatatacc cgtcccttta actgcctttc 2068501 aagttcttct gagagaagct gcgtaaactc gcctttctcc gccgccattt taaaatggtt 2068561 attaaccctt atgttaatta atggtatgac agcggtatca atgtaatcct tagcttgtaa 2068621 atagtccttg gcatcagtga ttctccacct catcgttctc cccctttacg gcaacaagcc 2068681 ttgcaattca ctgcaaggct ggtcatatta tgtgagctga tttaattggc gcgataattg 2068741 ttcaaatgcc tctttatcat gacgatctaa cgcgtcgtca atgtctttta ataatttttc 2068801 tctttggaat gtggaaatag cgtgctctaa aatctgttcc gccaatccct gatctttttt 2068861 attctcaaaa aggtttttcg gaatatgcgg gttggactcc agcaccgccg catattcagg 2068921 tgagctgtaa gccgaacgga aattaagctg gataaacaaa tcctgctgtt tatttaatct 2068981 aatatcatga aaagattttt ccgcgtcggt agtcatgaca ttctctttat agaaccggaa 2069041 cggaacttct tcaacacaat gtgttgacat tataatgcct ctcgggcaaa attcagcctg 2069101 ctccacaaaa tgaaccttct ccatgagaga atcatggctc attaagtagt tcaagatcca 2069161 aacgcactct cggcgcttta actgataatg gtttaaaaac caacggataa aatctttttt 2069221 ctcattgaca gaaacagggg tctgcatgta attccctcct ctatcgttcg tataatctat 2069281 atacttatat gttccacatg aatggttaat attcctgctt atctagaaaa ttcatcctcg 2069341 attcgcaaaa tcgtttcttc aagctcttca ttggctccgt ccatttcaag aacctttttc 2069401 aaaagcggca gcgcttcttt ttgaagacct tcttctaata ggaagcttgc gtattcatat 2069461 aagaaatctc tatcctcccg gtaatgaaga taggcagcct caaaggattg ttttgcttcc 2069521 tcgtattgct ctaattcagt atatgcgctt gcaagatacc aattgtattt aggatcttct 2069581 tcaccgtagc ttcgaacctc ttgaataaga tcaatgatct gatcataatc ctcttctttg 2069641 tgatacacgg caagaagtgt atgaagcgcc tcgacaaagc ccggatcaag cgcaagcgcc 2069701 tcctgaagca gcttcttccc ctcttctgac ttcccgattt tcaaggccat tttggcggca 2069761 taaaggaaaa gttctttgtt atattcatca tatctgatcc cctcttttgc cgtttttaat 2069821 gcctcttcat acattccttc agcttcatag cttttcgaga gcggcatata aagtgaagta 2069881 taagatggat caagctcctt taaatcagac agctgcttaa tagctgtttt cacaagcccc 2069941 gcctgtaagg ctgtaaaacc atagccgaaa atcgtattag gatcaggatt ctcatcgaca 2070001 gctttctcat accatggaat ggcatcctca aattcacctg aggcacttaa cgattctgcc 2070061 agtctttgat ggacattaac gcccccgatc tcactctgct cctcagccgt tgttttaaaa 2070121 tattgaaccg cttttgcata ggctccctga gcaaagtaaa gttctcccag tgcaaaatca 2070181 ataacaggtt cattgtccag aatggacttt gcctggaaaa gcttttgttc actgacttcg 2070241 aataacccct gcatctgata aagatccgcc ataagcagca aactttccgg atatgatgga 2070301 tctgtttccg gaatagtctc cagcacagcg agggcttttt cttcttcgtc aatatctatt 2070361 aaaagttcag cgtagaaatt cgtcagttct gtttcatttg gatataaatc atgtagatca 2070421 ctaatcagtg aaatggcttt ttctacatcg ccccactcgt aataaagctg ggctgcaatg 2070481 gctttatctt catcatgcag ctgtttttca gccttcgaga gcgtgttgag gcctttttct 2070541 gtttcacctg cttcaactaa ttttatggct tcttgaatca atgtattcaa atcggaccgg 2070601 tcctttcttt tcctatacaa catcaaccat acaaaaaaag ctttatttgt tcgggttaat 2070661 cttatcataa ttcagacgaa tgcccccggc aaataagatg cttctgtacg gaagggaatt 2070721 attgagtctt attagtttac caaaagatct tgagatagaa aatgaaaaaa ggaagatcgc 2070781 cctctgtaca gtaaagcagc tctttgacct gccggcttgt aagtaaagca catcccccct 2070841 tttcgttttt ctatccgttc tataagacaa gctatgtttt ttcgcctcga attatgatct 2070901 gcataaaaaa tcctgaagta aaacttcagg attttttcga aagcttattt aaatgctcga 2070961 agaaggttgg ataagaaacg tgaatggcat ccgtgtgctc gatttcaatc ggctcctccg 2071021 ttatacagga agcaatacca agcatcattc cgattcgatg atctccgtgg ctggacactg 2071081 cagcgccgcc tttcaacgtt tgtttgccat aaaccttcat tccatctgct gtcggttcaa 2071141 tttcagcacc cagcttgcga agctcagaaa caacagtatc aatacggttt gtttctttca 2071201 cttttagctc tgccgcgtcc ttaataacgg tggttccttc cgcctgagtc gcaagaagcg 2071261 cgatgatagg gatctcatca attaaacgcg gaatgatatc tcctccgatt tcaactgcct 2071321 ttagagatga cgtttctata atcaaatctc cataaggctc tgcaccgcta tcagcagatg 2071381 gtttgatttc aagttttgcc cccatgtttt gaaggacatc aataatacct gtccgagtcg 2071441 gatttaaacc tacgtttttc aatacaattc tgctgtttgg aaccatcgcg ccagcagcaa 2071501 ggaaaaacgc ggctgaagaa atgtctccag gaacaaaaat atcagcagct gtcagtttct 2071561 ggccaccagc aatggaaaca ctcgtttgat cttcagaaag cttaacgcca aaagcagaaa 2071621 gcatccgctc agtgtggtcc cgagatttat ggggctctgt tacagttgtt gtgccctcag 2071681 cctgtaatcc ggccagcaaa acagcagatt taatttgcgc gcttgcaaca ggtgatacat 2071741 aatcaattcc ttttaatgaa gcgccgctca ctgacagcgg tgtaaactct ccgccggctc 2071801 tgccgtcgat tttagccccc atttttttca aaggctcagt cacacgcttc attgggcgtt 2071861 tcgcaatgct ctcatctccg gctaccgcgc tgtaaaaagg acggcccgcc aatattccga 2071921 gcatcaggcg aatcgttgta cctgaatttc cgacatctaa aaggctttct ggctctttca 2071981 gggcatcgat tccttttccg tgaatcacga catcgctgct gctttgctca atgtgaacac 2072041 ccatttttct aaagcaatcg atcgtgctca gacaatctgc tcccggcaga aagtttttaa 2072101 ctgttgttgt gcctgccgct agcgcgccaa acataacaga gcggtgagaa atggatttat 2072161 caccgggaat atgtatttct ccatgtaagg tctgcacctt atctcgtttc attttttcca 2072221 cctcaatcag cataaaaagt ttcatattcc gcccgggctt caatgcattg ttctgccctt 2072281 ttgcggtcgt catcagactg aaaactgatc cttaaaatcc cgttaatatc ctctcgtgtt 2072341 tcgataatgc ggatattcgt gatactgatg cgctccgcag ctaagatcgc tgttatctcg 2072401 gatattacac ccggatgatc gggtacatcc acatataaat cataaaatgc aggtatcgct 2072461 cccttctgcc gaagcggcag cccgtcgcga taatccttgg ctgttttaaa ataacgaaat 2072521 agattttccg catcttcttg ttctacatat gtacggatct tgtcaatttc acgaatccac 2072581 tcatcaaaac ggtctaagat tttatcttta ttatgtaata aaatatcccg ccacattgcc 2072641 gggctgcttg atgcaatcct tgtaatatct ctgaacccgc cggcagcaaa acgcttaaca 2072701 agcggataca ggttttccga atgatgggtt tggtgaacaa ggctagctgc tacaatatgc 2072761 ggaaaatgac tgattacgct tgtaacgcca tcatgctcct ctggcgacat ttccacaaaa 2072821 tgggcattcg tccccttcag caggtttttt aactgttcca cagcttgttt gtccgttttc 2072881 tggcctggcg ttaaaatata aaatgcattt tcaaacagga actccttcgc agcggccact 2072941 cctgatttat gtgaacccgc catcggatgc cctccgacaa attgatagcg gctaggcagc 2073001 acttgatcag cgtaatcaac cactttttgc tttgtgcttc ctacatccgt aatcaaaagc 2073061 tcatgttcaa ttcctgaatg agccagctct tcaagcataa ccagtgtttg ttcaacaggt 2073121 gtcgcaatga ttactgtagc tgcctctttc acaccgctaa taaacgaatc agcacgatcg 2073181 tctatcacgc ctaattttaa tgccgctacc gcctgttcat cagagatgtc gattccgata 2073241 atccgtttgc cgggatgatt ttttttgatg gctagggcaa tcgaaccgcc tatcaatccg 2073301 agaccggcga gcaatattgt atctttcatt tgattcatac gtcatcacct ggtttataga 2073361 ctaaagaggt gatatttgat cacctcttat aaaatttcag ctaaaatggc aagtatttct 2073421 tcattttgct cttttgttcc gatcgtaatc cggagtgatg tcgggaaacc taatgcgttt 2073481 cctgaccgga cgatatagcc tttttccagc agagcctgaa acagttcatc agcaggacgt 2073541 ttaaagtcaa ttaacacaaa atttgtctgt gaagggtagc actttaaacc atgagttttc 2073601 gcaaaatcat aatactgctg aaggcctgca ttattttgct cgacacagga agcaataaac 2073661 gcttgatcat caagtgctgc aatcgccgca gcctggccca gacggctggt attaaacggc 2073721 tctctcgccg gctcaatctg gcgaatcagg ttctcgtcag caattccgta tccgactctg 2073781 agcgctgcca gaccgtatgc ctttgaaaat gtgcgcaaaa tcatcaaatt ggaatacttg 2073841 cttaagagcg gcacggtttc cgggtaatcc tctgctgtta catattcata atatgcttcg 2073901 tcaagaacga caaggacacg agaaggaacg cgctccagaa atgcgagtaa ttctccttca 2073961 gatgtataag tgccagtcgg attattcggg ctgcatatcc aaacgacttg tgtctgttcg 2074021 tcgatggctt ctaacatggc gtctaaatca tgtgagccgt cgggacgaag tgcaatttca 2074081 cgtacttcag caccttcaat aaccgcatta tgtttatatt gcggaaaagt gggggcagca 2074141 gtaaccgtgt ttgttttatc gtttaaaaat gcccggcaga tgatctgtat gatttcatca 2074201 gaaccgttgc cgaaaataag tgatgtttcg ctgacattga ggtgcttact gagccttgtc 2074261 cgcaaagcgg cgctataccc gtccgggtaa agggctagct gttgaatctc atgatgaagc 2074321 gcctcttttg cagcctctga acagccgtaa ggattctcgt ttgaagcaag cttcacaact 2074381 ttatccaagc catattctga tttcactgct tcaatcggct ttccaggctg ataaggcttc 2074441 agctgtttta aatgttcttt gatacgcaaa tcagtcacct cattttaaac tgtacaagcc 2074501 gctaaacgcc attgcataat cctcaaactc ctgcagcgcc tgatttctcg tttcagcgct 2074561 gatgagccgg tcctttaatt cttctatttt tctgacgagc gcacttccca ctacgacacc 2074621 gtcactaatt tcattcatct ttatgacctg ttcacggttt gatataccga accctacagc 2074681 aaccggaaca gtgctgagat tcttcacagt acgaatgaac gggtacacgg atgaattgaa 2074741 ctcattgcgg acaccggtca cacccagaga agatacacag tagacgaacc cctcggcttg 2074801 ttcaataatg gttttcaaac ggctttcgct tgtcggcgca actaaagaaa tatacgtcac 2074861 ctcatggctt ttacattcct cttgaaggct gttgctttct tctaatggca gatccggaac 2074921 aagcagaccg tcaatatgat tttcccgcag taaagcgaaa aagtattctt tgttcaattg 2074981 taacacagga ttataatacg taaagaggat aatcggaata ttcactccgt tttttttcat 2075041 ttctccgcct aattcgattg cctttacgat attcattcct tgatcaagcg cccgctttga 2075101 agcccgctgg atcaccggac cgtctgcaag cgggtcagag tatgcaacac caagctccaa 2075161 tgctgtggcg cctgcttttt ggagtgactt cgccagttca atcgaaacct caggaactgg 2075221 atcgcccgcc gtaataaacg ggataaacaa tttttctgat ggttgaagat ccaatttaaa 2075281 catgggcttt cacctcttct tccaatacat tcattaatgt gttgacatcc ttgtctcccc 2075341 ggcctgataa acagacgaga atgagttgac cgcgatccat tcctttggcg agtttgaatg 2075401 ctttcgctaa cgcatgggca gattcgattg ccggcaaaat cccctctttt tctgacaaaa 2075461 gctttaatgc atccaccgct tcttcatcgg ttatactgtc ataagtgaca cggccgcttt 2075521 tatgcaaata tgcatgctcc ggaccgattc caggatagtc gagaccggct gaaatagagt 2075581 agggctcaat aatttgcccg aactcatcct gaatgagata agtcaatgaa ccgtgaataa 2075641 cccctacggt tcctttcgaa atagtggcgg catgaagagg tgtatcaatt ccttttcctg 2075701 ctgcttcagc gccgatcagt tcaacatctt catttaaaaa tgcctgaaac atacccatcg 2075761 cattgcttcc tccgcctaca catgccacta ctttatcagg catagtgcct tcaatacgtt 2075821 tcaactgatc cttcgcttcc tctccgatca ttttttgaaa ttcacggacc acttgcggat 2075881 aaggatgcgg gccgacaact gatccaatca tataaaagtg atcctcacaa tgctgaaccc 2075941 agtaccggat cgcctcattt gtggcatcct tcaatgttcc gtttccgctt gttacaggca 2076001 ctacctccgc tccaagaagc ttcatgcgga aaacgttcag agactggcgg gcaacatcct 2076061 cttcacccat aaacacagta caggaaaagc cgaatttggc tgcaactgtt gcagcggcaa 2076121 caccatgctg gccggcaccg gtttcagcaa tgattttcgt tttgcccatt tttttagcaa 2076181 gcagcgcttg acctagcgca ttattgattt tatgagaacc tgtatggttt aaatcttctc 2076241 gtttcaaata gattttcgcg ccgcctaagt attcagtgac tcgatcagcg tatgttaatg 2076301 cagtcgggcg tccggaatag tcctttaaca gcttataata ctcttcacga aaagcgggat 2076361 catccttgat ttgtttaaat gctgtttgta tttcatctaa cggctgcatg agtgtttccg 2076421 gaacaaactt tccgccaaaa tcaccgtatc tgcctatttc attcggatat ggatacatat 2076481 cggttcatcc tttcttctaa aagcctcatc agattctgat ctttttgtcc gtttttttca 2076541 attccgctgg caaggtcaat tccttctggc tgccatttca ataggcgtgt gatgctatcc 2076601 ggattcacgc cgccagcgat aaagcagcgt ttaccaatag ccgcctgctg atattccggc 2076661 acacattccc aagaaaatgc aacaccagtt ccgcctctag acccttttac agatgaatca 2076721 atcacaaagc cgtcaacatt atctttaaag cgggctattt cttgagttgt gttatcttga 2076781 tggtgaagcg ccttccatat ttcacagcct gtcagcttgc gaagagcagc agcatccgcc 2076841 ggtttttcat caccgtgaag ctgaatgacg tcgagcttca agctcttggc aatacgtgac 2076901 atcgtctcta ttgattcatt aacaaaaaca cctgcaacct gtttttcgac acgaacttgg 2076961 ttcagccatt ttttcacatc ttccggagat acttttcgtt tgctttcagc aaaaataaat 2077021 cctaggtaat cagcctgtga ttccgccgca agctgcaaat cctttagtga ccgaataccg 2077081 caatatttta atgccggttt cttcacaacc tcactcccta aacaaagcat ggattgcttt 2077141 acgctgagaa gtttgtctca tcaatgattc accgataagt acagctcgtg ctccatgttc 2077201 tttgacaaat gttaaatgtt ctaaagaacc gattccgctt tcgctgacaa gcagtgattc 2077261 tttcggagca agagatgcga tttgttctgt ctgcatgata gaggtttcaa aagtttttag 2077321 gtttcggttg tttatgccga gaatatcagg cgtgaatact ttcaatattt gttctagcgt 2077381 tgttgcatca tgaacctcca ctaacacgtc catctccttt tcacctgctt caagatataa 2077441 ttcatgaagg tgtaagggat caagcacttc gccgattaac aatatggcat ccgctccgat 2077501 tcttcttgat tcctccactt gaagagaatc aataataaaa tcttttctga gtacaggtat 2077561 cgaaacagcg cgctttacgt ctgataaata gctgttttcc ccttgaaaaa acggggtgtc 2077621 tgttaaaacg gaaagcgcat ctgctttcgc agtttcatag tcttttgcaa tccgcacagg 2077681 tacaaaattc tctttaataa gcccttttga cggcgacgct ttcttcactt cagcaatcaa 2077741 cccgataaac cgattcaggc ttgccagcgc ctctttaaat gaacgttttt cgaaaggctg 2077801 ctctaccggc agaaccagtg ttttcacttc ttctttcttt tgtttgatga ttttttcaag 2077861 catagatctc ttcctctttc tgctttagtc gttcaagctg cgcggcagcg cctccgcttg 2077921 taatcgtctc taacgccagc tccgttcctt ccttcagtga ggcggtaatt cccgccgtgt 2077981 aaatcgcagc acccgcatta aaagccgtaa tagataaagc ggaactgctg cttttatttt 2078041 caaaaatatt ctgaatgaga taagcgctct ctttcggaga ctgcacctgt aaatcttcaa 2078101 gtctgccatt tgtgaaaccg aaatcttcgg gtgaaacggt atactcccgg cgctctccgt 2078161 cctttaattc aatcacgtcg gtcggtgctg taattgaaag ctcatctaaa ccgtcacggc 2078221 ttgatacaaa cataacgtgc ttcggctgaa acgtctccag tgcgcttgcc atcagtccag 2078281 ctttttcaac agaatagacc ccaatcacct gacgcttcgc ctgtaaagga ttgctgagcg 2078341 gcccaagcag attaaatacc gttctgaaac ctagctcttt tctagtacct gctacatgtt 2078401 tcatagacga atggtaaagc ggcgcaaaaa gaaatcccat gttgtttgtt tcaatgctgc 2078461 ttttgacctt ttcgggagtg gtttgaatag aaacctctag ctcctctaaa acatcagcgc 2078521 ttccgctttt agaagagaca gagcgattgc catgcttagc gattttcgca ccagctgccg 2078581 aggcaacaat tgccgaggcc gttgagatat taaaagtgga aataccgtct ccccctgttc 2078641 cgcatgtatc aacaatatca ggaagtccat cgactgtaag agcgtgtgcc cgcattgcct 2078701 tcacaaaacc cgcaagctct tctggcgtct ccccccgatg agcaagaatt gacaatatcc 2078761 cccccatttc agaaggagtc atttccgctg ccatcatcat attcatcagc gtttcagcct 2078821 caccggcagt aagggttttt ccgtcaacgc acaattgtag aaatctgttc atcagcttta 2078881 tcctccttgc tatgaaacat gtcttctgca atatgaatcg ttttcagcag cgcaccggct 2078941 ttattacagc tttcttcgta ttcggcttcc ggaacagaat cagcaacaat gccagcacct 2079001 gcctgtatcg atgcaacacc gttctttaca ctcatcgtgc gaatcgtaat acaagagtcg 2079061 atattcccgt caaacccaat gtaggcaata caccctccgt atgtctctct cggtgttggc 2079121 tcgagttctt gcaaaagctg catggcacgg attttgggtg cgcctgttaa agtccccgcc 2079181 gggaaagcag acatcagtgc atcgacagga tgaacccctt ttttcaatcg gcctgtaacc 2079241 accgagataa tgtgcatgac atgtgaaaag gaaacaattt ttgtgaactc cggcacagaa 2079301 acagaaccat actctgctac tctgccgata tcgtttcggg caagatcaac gagcatgtaa 2079361 tgctccgctt tttctttttc atccttcatg agctcaacct tcagtctctc atcttcagct 2079421 ttgtctgcac cgcgttttct cgtaccggca atcggatgga tttctaagtg cccgtcttga 2079481 acgtgtatta accgttccgg agagctgccg actatttctc tgtctagcag tttcatataa 2079541 tacatatacg gcgaaggatt gacgatccta agcactcggt ataactcaaa agcatctgct 2079601 tttatcggca cctcaaattt ttgtgataaa acaccctgga agatatcgcc tgcttttata 2079661 tagcttttga ttttttctac atcagccata aaagccgatt tttcataatt agaagatact 2079721 gtctcaaagc tgggtgtctt gtatgaatca gcagaaagaa acagctcttt tatgtttttt 2079781 tggtccatca ttttttcaat gagattttga agctccagat gattttgatg gaatacatcc 2079841 attttttcgt tttttgtttc ctctccagtg agccttgcat attggataaa gtggacgttt 2079901 ttggtttcat gatcatacgc aattaatgtc cggcaaacaa acagcataca cttttccatg 2079961 tctgtttctt tggtatgcga aggaacagaa ggctcaatca gcgggatcat atcatagctt 2080021 aagtacccga cagctccgcc gacaaaagga atgccaagct caggtgtttt gattttgtat 2080081 gtggtattca tccagttcag cacttctttt agttcatttc ctgtgtaaag agatttgctg 2080141 tcctgatcag cggccgaaaa acggccctgc tcttctttaa ttgtgagaaa tggattcagg 2080201 ccgataaacg aatatctgga ccaagtggat gtatcgtcct tgctttcaag aagatacgta 2080261 atctccctgt caagcttctc tatcatttga atgggtgtca gtgtatcgac tgtgaaggtc 2080321 tccacaatcg gtatcgtgtg gtgggacaag ctgtcctcta aaaatgcgga aatgtttgat 2080381 tggaaattca ttgctctcac tccttatggc aaggagaatg agaagatggc atgagaggat 2080441 aaaatactat ataacaaata aacccaaaag aaagacttct tttgggtaga ataaacataa 2080501 tgtctcagct caactaaact cattctctgc taccctattc tctaactcaa ctcattctaa 2080561 ttgctttata cacactcttg tgtatttcta agctgttctt atcgtattac aattcagtat 2080621 tttttgtcaa tgataaatcg ggcctcaata cgacaacttt ttctaaatat acatgtctga 2080681 tctgatcctg agggacatct gtctggaccg tcatcatgac tcttatgcac tttttcagac 2080741 cgcctgttac gtccatttcc tgcatacatg ttaccggtac atactgccat cctgaaagct 2080801 cgcgaacagc ttttgccggg aaaacagcgt gcaaatcagg tgtagccgac agaagcattt 2080861 gaacaacatc ttccggtttt gtatgatttt cttctatgat tttctctaac agctgtttag 2080921 ttttttgtaa aatttcttct tcagtatccc gttcaactgt agttgctccg cgaattccgc 2080981 gaatcatcat gatgtctcct ccaatcgcca tttgttcagc cagctctcaa gttcatttct 2081041 ggaaaatgta tgatcagcaa ctttccctaa ttcgttgagc acaataaact gaatcttccc 2081101 gccacgggtt ttcttatcat tcatcatacg gttcaagaga accgaagttt ccgtctcttt 2081161 tctgatttga cttggataac ccaggctttt tagccagctg accaaacgtt ttctgtccat 2081221 ttcacagcct acagtctttt cgcttatata taaagcaaac tgcattccga gggctacggc 2081281 atcaccgtga gtgatctgcc catatccata ttccgcctca acggcatggc cgagcgtatg 2081341 cccaaagttt aagtaagctc ttatcccctc ttctttttca tcctgctgaa cgacagacgc 2081401 tttaattgaa atgcctttaa aaatcatgtc attcagctga tcattagtga tatcacgcag 2081461 tgagtggata ttcagcagct cctccagaaa cgctctgtca tagataaaag cgtgtttaat 2081521 cacttctgcc attccggacc taagctcttt ttcaggcaga gaacgcagga aatctgtatc 2081581 atagagcacg gctttcggct gataaaacgc accgattaga ttttttccaa gcggatggtt 2081641 cacggctact tttcctccga ctgcgctgtc atgcgccaag agcgtcgtag gcatttggat 2081701 gaaatcaatg ccgcgcataa aagtggcagc cacaaaaccg gcaagatccc ctacaacacc 2081761 gccaccgaat gcgatgatgc atgaggagcg atccatatga aaacgaatcg cttcactctg 2081821 caattttgtg tacatgtcca tggattttgc ctgctctcca ctcggtaccg tcactttttt 2081881 cacaggccat ttttcttgca gcaaatggag catttcatca ccatacaggc ggtccacttc 2081941 ttcatccgtg acaaacataa tccttgttaa aggcctgttt aaagaggtta atagttcgca 2082001 agcctttttt ctgatacctt gtccgataaa aacaggatat gacgaggaag cagtttgaac 2082061 atgcagtgtc ttcattaaaa ttccctcgac agttttctca tattctccac attttctcta 2082121 atgcggtcaa tttgatctaa tccgaattgt tcaacgactg cgttcgcaat ttcccaagcg 2082181 acagccgctt cagcgactac acttgccgca ggaacagcac agctgtctga acgttcaatg 2082241 ctggcagaaa acggttcttt cgtttcaata tcgacacttt tcagcggttt atacaaagtc 2082301 ggaatcggct tcatgactcc gcggacaaca atcggcatcc ctgtcgtcat gccgccttcc 2082361 agtccgccaa gtctgttagt agcacgggtg tatccttttt cctcgtccca aatgatctcg 2082421 tcatggactt cgcttccatt tcgccctgct gcctcaaatc cgatgccgaa ttccacacct 2082481 ttaaatgcgt taattgacag aacagcggca gcaagcttgc tatccagctt gcggtcataa 2082541 tggacatagc tgcccacgcc taccggcatt ccctcgacaa tgacttctac tattccgccg 2082601 atggaatctc cgtttgcctt tgcttcatca atggcagcca tcattttttt gcctgcctct 2082661 tcatcgtagc atctgacagg agactcttcc gttacacgct gcaagtcttc aattgacgta 2082721 tactctgttt tttcagcttt aacagcgcca atttgcaaca cgtggcccgc caccttaatg 2082781 ccaagctcag aaagaatctt tttagctaca gcccctgccg ccactctgac agttgtttcc 2082841 cttgctgaag aacgctcaag cacatttctc atatcacgat gattatattt aattgcaccg 2082901 tttaagtcag cgtgcccagg tctcggtctg gaaatctggc gcttcatttc cttttcttca 2082961 tcttctgtaa tcggagcggc gcccatgatt tttgtccaat gcttccaatc gttattttca 2083021 actacgagag caattggcga accgagtgta cgtgcatggc gcaccccgct cataattttg 2083081 gcctggtctt tttcgatctg catgcggcgg ccgcggccgt gtcctttttg gcgtctggca 2083141 agctcaaaat tgatatcttc ctccgttatg taaagcccgg caggtacacc ctcaataatg 2083201 gttgtcagtt gggggccgtg tgattctccg gctgttaaat atctcatgac ttcttctccc 2083261 ttcatcgcat taacgctttt aagtaagact actataacat atttttcagc aaaaagtcag 2083321 tctatctttt ttgataaaag aatgtatcgg ctgggactag gccaaatttc tcgggattga 2083381 agatttgctc ggtgctgccg acaaaaagaa ctccattctt cttcaagcta tgtgccattt 2083441 ttaaatacag ctcttccttc gcgctttctg taaaataaat aaatacattg cggcacacga 2083501 ttaagtcaaa gtcttgttca taacgatccg ccagcaaatt gtgctttttg aatgtaatat 2083561 tctttttgat ttccgttttc acttcataac ttctatttgc gttttgcgta aaataacgat 2083621 ctttcacaga tagcggcact tcctgtaaag accgctcctg ataaacgcct tttttcgctt 2083681 tttccaatgc tttttcatca atatccgtcg ctaaaatctg atagcccgga agaccttttt 2083741 gctggtccaa aagcatggca agcgtgtatg gctcctcccc cgttgagcag gcggcactcc 2083801 aaatttttaa aggcctagag gtcttgatta acggcagaat tgcagtctca agaacttccc 2083861 atcttttata attacgataa aattctgaaa cattgatcgt cattctgtcc aatgtttcat 2083921 ttaagagagc ttgatccttt tccaatgccg cagcaaagtc cttaaagctt tggaacccct 2083981 ttttctcata aagtgacgtt agccttctct tcatttgtgc ttctttatat agtgttaaat 2084041 cgactccggt taattgtttc catttcgttg taaatacgct gtatgtatcc atctctactc 2084101 tcccagtctc gctgtctttt tgtcctagta tagcttgttt tatcaggaaa ttgtattgtt 2084161 tcaataaaaa aatcagcttt tcagctgatt ttagatcgtt gggaaaggca gaggtctgat 2084221 gcacactgcc attcaaccct ttattcactt taatgtaaac ctttacaaaa cagaacaaaa 2084281 accggcggcg ttatatgttg ccggctctgt tgcttatttt cacaatgatt aatagatcca 2084341 gcctgccata agctgctgat atgatactaa ttcttcattc ttaaagaaaa tgttaatctc 2084401 gcgttctgca ctttcgagag aatcagagcc gtggatgatg ttttttccga caaacatgcc 2084461 ataatcccca cgaatcgtac caggtaaagc ttctttaggg tttgttttcc cgatcagctg 2084521 tctcgtcact tcaatgacat tttcgccttc ccacaccatt gcgaatacag gtcctgaagt 2084581 aataaactca acgagctctc cgaagaaagg cttaccttga tgttcggcgt agtgtttctc 2084641 agccatttgt tcagtcactc tcattaactt ggcgccagct aattgtaagc ccttacgttc 2084701 gaatctagat aaaatgtccc caatgagctg acgttggaca ccgtctggtt tcaccatgat 2084761 aaaagtcttt tccatcatat tctccacccc atcattatgt atgtataggc tttcacactg 2084821 cacaccgaaa tcgtaacatc tttctgataa ttaatcaatc cggggcggag aaatttctta 2084881 atatctacaa aaattaaaat tttcttttac cgatatattt tgcgatggct gcaagagacg 2084941 agcgtgcgcg ccctcgagga agcgtgttta atttctgaaa agctttctgc agatacattt 2085001 cgcttactgc catagatgct tcaattgcat ctgttttttt gatttcttca atgattggtt 2085061 caagctgttc ctgcgttgtc tcactgttaa tcaatttaag ctggtttttt aatgcaggat 2085121 ttttcagggc atacagcact ggcaatgtga cgtttccttg aagcaaatct cctcctacgg 2085181 gtttacccag ctcttcctca gttgaagtaa aatcaagaat atcatcaata atctgataag 2085241 acatgccgac gtaataccca aaccagtaca atgccttatg aatcttctca tcagctccag 2085301 acgcaatggc accaagctgg cagctgaccg cgatcaagag agctgttttt cttttgatac 2085361 ggcggagata cgttctgaga ttttgttcca tgttgtattt gtctttgatc tgctcaattt 2085421 cccctagaca aacttcaacg atcgtctgtg acaaaatcct atgggctttc ggttcgttaa 2085481 ttctcgtcat catttcaaga gatcccgcaa gcatataatc gcctgtgtac atcgcaatac 2085541 gattgtccca ctttgctttg attgtcggtt ttcctcggcg aagctctgca tcatcaatga 2085601 catcatcatg aaccaaagat gccatgtgaa tcatttccag agtgacggcg acatatttaa 2085661 tcttattaat atcataatcg ccaaacatgc cagaaagcag cacgaaaaca ggccgaatac 2085721 gtttccctcc ggcctgcagc aggtgaagac ctgcctcgct taaaagcggg taatcggaac 2085781 gtacggtttg ttcaagttct ctttcgatta catcaatatc gtcatttaaa aaagagtagg 2085841 ccattttaaa tttcatatca ttcacccaaa catctgtgtt ttcatttcca tccgatatgc 2085901 gtggcagcga ctccgccagt aaacgaatga tatttaacat ttttcaggcc cgcctcttca 2085961 aacaggcctg ccagttcctt cattccaggg aaatctctgg ctgattcttg aagccaagaa 2086021 tattctttat agctcttcgc aaacagtttc ccgaaaaacg gcataatata cttaaagtac 2086081 ataaagtaag cctgtctgaa tccgaacatt tccggctggg acgtttccag acataccacc 2086141 tgcccgcccg gcttcactac acgtctcatc tctttcagta cagtcaagta atcagggaca 2086201 ttgcggagtc cgaagccaat ggtgacataa tcaaatgtat catcatcaaa aggaagctcc 2086261 atcgcatttc cgtgcagcag ttcaatttgg ctgaatccgc cgtcttttac tttctgctcg 2086321 ccgacactca gcatattttc actgaaatcc aagcccttga tctcgccgct tttgcctgcc 2086381 gcttttgcaa gagcgatcgt ccagtcagcc gttccgcagc agacatcaag tgcttttgcg 2086441 ccttccttta cattcatgat gcgcatcgtt ttgtcgcgcc attttttatg ctgctgaaaa 2086501 ctgatgacag agttcatttg gtcataattt ttatatattt tttcaaatac tccgtgtacg 2086561 cgctgttctt ttgagtcctg cataatggtt tacccttctt ccactttctg atgataggtt 2086621 tgatcttggc tgattgtctt cagacggttt attaaaatgt tctgaatagg tgaatttaga 2086681 ggcagaagtg actcaatgct gtttttcgct tttttaaaac aatcttctaa tatctcttct 2086741 tttgtttttc ccagctgtat aaaactgccg atcacatcca gaaatgcatc atttccgttc 2086801 ataagccgct taaatacaaa aaaatcactc gacagctttt tccagcgcgg gaggttgaag 2086861 tgttccgcca cacgatggaa taaagctgat tcaacgatgc cgacactttc gaaaaaatcg 2086921 ttttcgtcct tgaaagaacg gtcatacaga cgaattttat gttcgttgat ttctttaatg 2086981 gctgtagcaa gcgtccgaat catgtagata tccttcattt cagatagtaa agagtagtac 2087041 agcccgctga aataatcgcc cgcgagaaca gtcaattggc ggtttttgtt ttcgtctcgt 2087101 tttatgactc tagctgtcgt cacttcatca tgggtatcaa gggcgctttg tacaagcatc 2087161 gctgttacaa tataattttc tctgtcgttg ttttttatgt cggcttcttc aaataaagca 2087221 tgaaaaagaa gaagcttatc ctcatcaatt ttcggcgcag aaatatgctt cgctaaataa 2087281 ggatgagaca gcttttgttt taatttcgtg ttcagattgg ctaaagttcc gtagatgtct 2087341 tgcaaaaata tcacccttgt ccccaaattc acatttattt cttaatctat gtatgagttt 2087401 tatcttttca ttcgcttacg caggtatcat tatagcataa aaaaaagaaa ttggctgtat 2087461 cctcccgctg tttgcgagca tttgctttta acagcgggga cagccagctt attttttttc 2087521 gcttttcatt tctccgtacg cggtttgaat cagtgcctct cctctgactt taatggcaga 2087581 agtatgctct gtaaactgag cgatgatcac ttctcccttg tcgagttttt cggaatggtg 2087641 aaactttgtg tctgttcctc ttgtcaggcc gatcacattc actccgtcct caacggcttt 2087701 aatgacgaca aaatcacttg aatgcttttg gttcatttat agcaccctct atctttatta 2087761 gtcctggcgt ttaatatgtt ccaatacttc tgcacgggca gcggcatcat ctttaaaaac 2087821 gcctctgact gctgaagtca cagttttcgc acccggtttt cttacaccgc gcatcgtcat 2087881 gcacatgtgt tccgcttcaa ccactaccat tacgccatgc ggatcaagcg tttctacgat 2087941 gctttctgca attgtagaag tgatgcgttc ctgaagctgc gggcgctttg caacggcttc 2088001 aacggcacgt gccagtttgc tgagtcctgt gacctttccg cctcgcggga tatatgcaac 2088061 atgtgctttt ccataaaagg gaacaaggtg atgctcacac atagaatgaa acgctatatc 2088121 ttttacaaga acaagctcct catggttttc accgaagata gtctggaaat gttcttttgg 2088181 atcttcattc aagccggaga atacttcggc atacatcttt gcgactcttt tcggagtatc 2088241 aagaagccct tctctattcg ggtcttctcc gatcgcttct aaaatttgac gaacagcttg 2088301 ttcgatttgc tctttattaa cttctttcat gttctatgtc ctccaccaat gaatacattt 2088361 aatttcgatt ctagcacata tgccccgcta aaagcaaagt gaatgccctg tcaggaagcc 2088421 catgctcttg aaatatgaaa agccccttag aaaggggctt ttctgtgaag aaataaagtg 2088481 tatgtaagct agatgcatac acgatctata ttcacaatta ttttccggca actgcgtctt 2088541 taagcgcttt acctggtttg aaagcaggta ctttgcttgc tggaatttcg atttcttcac 2088601 ctgtttgagg attgcgtcct ttacgtgcag aacgttcacg cacctcgaag ttaccaaaac 2088661 cgatcagttg gattttatca ccgtttttaa gtgcatctaa gatcgtatca aaaacagagt 2088721 caactgcttt tgtagcgtct tttttagaca attcgcttgc ttctgcaacc gcattgataa 2088781 gttctgtttt gttcatgcct ttcacctcct cccaaaagga tacattcagt tcgtttatta 2088841 tcatttcttc acagttcagt ctgattctaa acctgtctca gaaaaaaatg agagcaagta 2088901 agagaaagac aattaaacgg ctttttaaga aaaactgcac tctgaggaat gtttgtccaa 2088961 caaagtgaag aatttctgta tgtagagtaa cacatataaa aagccatatc aagcatttta 2089021 aagcgtcaat cccttgctcg tcaaggattt aaggtgattt accgaacgaa tattcctttt 2089081 tttccttttt tcatcctatt ccttgatcct tttccattat taagagcaaa gaaaaaagac 2089141 ctcccattct ataaagaggt ctaccggtat tacaggatga tggcgattaa gccgccagag 2089201 ccttcgttta tgattctttc taatgtttct tttaatttat accgtgcgtt ttcaggcatc 2089261 aatgacagct ttgcctgaat cccttctctc acaattgagc tcagcgacct tccgaagata 2089321 tcggaattcc agatggagag cggatcatcc tcaaagtcct gcattaaata gcgtacaagc 2089381 tcttcacttt gtttttccgt tccgataatc ggggcgaatt cgctttcgac atctactttg 2089441 atcatatgga tcgacggagc gacagctttc agcctcacac cgaatcgcga gccctgcctt 2089501 ataatttccg gctcatcgag actcatatca gctaaagcag gcgctgcaat gccgtatccc 2089561 gtctgtttga ccatttttaa ggcatcagac acttgatcat attctgtttt cgcatgggcg 2089621 aagtcttgca tgagctcaag cagatggtct cttcctctga tttcgacgcc cacaacttct 2089681 tttaggattt gatcatatag atgatcaggc gcgtacaaat caatttctgc caccccttgg 2089741 cccagctcaa ttccggctaa tccggcactt tcaatgaatt caaactcgct gaattggccg 2089801 acaaccctgt ctacgtcccg gagccgttta atatccttaa ccgtttcctt cacggactcc 2089861 tgatagcttt cacgcaacca atggttttct ttcagcacca ttacccagct tgggagattg 2089921 acattcactt ctagcaccgg aaactcgtag agggcctctc tgagcacact cagcacatct 2089981 gattcccgca tgctctctac actcattgcc aataccggga tatcatattt ttcgcttaaa 2090041 tcctggcgca tggcttccgt ttccgggtga tacggcctga ctgagttgat gaccataata 2090101 aaaggtttgc caacctcttt cagctcttca atgactcttt cttcagcctc tatatagtca 2090161 cttctggcga tatctccaat ggtgccgtct gtcgtaatga caactccgat ggtcgagtgt 2090221 tcttgaatga cttttcgtgt gccgatttca gcagcctcat gaaatgggat cggttcttcg 2090281 taccaaggcg tattgatcat ccgcggcccg ttttcatctt catatccttt agcgccgggc 2090341 actgtgtaac ctacacaatc tactaatctt atattcacat cgagtccgtc tgacacatga 2090401 acagacatcg cctgattcgg aacaaattta ggctctgtag tcataatggt tttgccggct 2090461 gcgctctgcg gcagttcatc ctgcgctcgg gcccggtctg cttcgttact gatattcggg 2090521 agcaccacaa gctccataaa ttttttaatg aacgtggatt ttcctgtacg gacagcacct 2090581 acgactccta agtatatatc gcctcctgtt cgttcagcga tatccttgaa aatatcgacc 2090641 ttttccaagt gatcccctcc cggacttcct atccttttca attttattaa gctctttcaa 2090701 tcaaacacag gacactatat gtgtatgacg ttgtcctatt tgaatatgac atctttagaa 2090761 aatttctcat cctcaatcta ttaatataaa aaaacctttc tccctatttg tatgcaaggg 2090821 agaaaggttc attccttttt catatcattt tctaaaaaaa caggttcctg tttgtcattt 2090881 accgtatatt ttacagaaaa cgcggggaca aagggggttt catgccaaat catatcctgg 2090941 atttcagtcc cgggtttaaa cgtttttttg ctttttttga ggcaagaagc cagctcagtc 2091001 cggtaatcgg catatatttc tccgtctccg tcaatcataa gcggcaagga attccctgag 2091061 attgggcttg tcactgtaag agagctgcca tccccaagct tcttctcatc gagtgtaaat 2091121 aaatcacgag atagcacatc cttgtaaggc ggatattgat gctcctgacg atacatttgg 2091181 atgcgcaatt tcacatcgcg aattttttct gccatcttta gatcaattaa tttaacagtc 2091241 ggatcgttct ctacgtcaac aagcacgtat tgatagtctc ccccgctttc aaatgccgta 2091301 cttggaggtt cagctatgta tcttggcgct aaccggttaa agtctatcgg atatttttga 2091361 tatagcggtg tcgacatatc tttggtttga ataggaagca gccctccatt tgccttttga 2091421 aattcatcaa cagcagattg aacctgcttt agctggtctt gataaggaat ggcatgcaca 2091481 ctgcttttcc gttcatttgg atataaacat ccggataaaa acacgactgc cgcaaaaatg 2091541 attgcgcact tcagtttacc catacagcac ttccttttac agctttattc attgacaggg 2091601 ccgctaaaaa ccacgacaaa cacaataatt ccagatatga gcatacacat gtatgcgaat 2091661 gatgaaatcg caatcttcaa aaaacggttt tggcacttaa agcggcttaa atagatggaa 2091721 gctacagcca gaaacatcag acccatggac cctagagcaa accacatttt catcaatgcc 2091781 agattcaatg acgtgcgcct ccccgatatg taagatataa gcgttatatt atattttaat 2091841 atacagcgcc ggaaaagatc aaccagattt tccatccatt gatagaacaa aaaaactgaa 2091901 gcaaagaggg ggaccttcgc ttcagtcaac ttgactatat tcacctgcac gtttaagaaa 2091961 cactctcttg gacttcgatg ctatagtatg cgacttggca tacagatgca tcctctattg 2092021 cctaaatcgg caaaatgttt caggagatcc caagacttgg gtgttcttct gtttttcggg 2092081 ctttcgttca attaagatat gcgattcacc atttgattga cacttttact tcacttgatt 2092141 ttcaaacgta tttaccaaat cctccatctc gtgggttttc cctctcgcca ttaaagattc 2092201 aacagcggtt tccacttttt gtccgttgaa taggacctga tggagagctt ctgtaatcgg 2092261 cattttaaca tcatatttct tcgaaagctg ataagccgct ttcgtcgtgc ggacgccttc 2092321 gactaccatt cccatctctt caagaacatc ttcaagcttg tacccttttc cgagcaaatt 2092381 gcccgcacgc cagtttctgg aatgaacact tgtgcacgtc acaatcagat cgcctactcc 2092441 tgtcaatcca gagaacgtca agggatttcc gcccattttc gttccgagtc tcgcgatttc 2092501 ggcaagtccg cgtgtaatca aagcagcttt ggcattgtca ccgtacccta aaccatctgt 2092561 aattcctgca gcaagggcaa taatattttt taaagcccct ccgatttcaa ctccgataat 2092621 gtcaggattt gtgtacaccc gaaaattgtg attaataaat agatcctgca cctcttctgc 2092681 tgccctcatg ctctttgaag atgcagtaac agttgtgggg tgccgcagcc ctacttcttc 2092741 cgcatgactc gggccggaaa ggacaacgat atcttttctg acatcactcg ggagctcaat 2092801 ttccataatt tcagaaatgc gcagaagtga atctggctca atacccttgc tgacatgaac 2092861 aaagactgcc tttttcgtta taaaagggac agcctgtctc agcacttccc gaattgcttt 2092921 tgtcgggacc gcaacgataa tgacatctgc gtctgaaaca gcctctttca tatctgttgt 2092981 tcctttaatg gatgtagaca gcttaacatt cggcaaataa tctttgtttt catgcaactc 2093041 attaatttga tgaattaaat ctgcacggtg agcccacaca cacacttcat ttccattatc 2093101 agttagaact aaagccagtg ctgttcccca actccccgct ccaagcattg tgactttttt 2093161 catgtttgat tcacaccttt ttattttcta gctcttgcaa atattttgat tggtgtcccc 2093221 tcaaaaccga acgcgtctct gattcggttt tctaaaaacc gttcgtatga aaaatgcatc 2093281 agttccggat cgtttacaaa cacaacgaag cttggcggct ttaccgacac ttgagtcgca 2093341 tagtaaattt tcaaacgaga accgttatga gtcggtgtcg gattcattgc cacagcgtcc 2093401 atgatgacat catttaagac gtttgtttga actcgaagtg aatgattttc actagctttg 2093461 ataatcgcag gcatcagagt atggatccgt tttttcgtta aggcagacat aaataggatt 2093521 ggcgcataat ccagaaattg aaaatgatcg cgaatatttt cttcaaattc tttcatcgtg 2093581 ctctcatctt tgtcaacagc atcccatttg tttacgacga tgacgacggc cttgcccgct 2093641 tcgtgtgcat aaccggcgat acgcttgtcc tgttcaataa tgccttcttc gccatccagc 2093701 acaaccgcca cgacttctga gcggtcaatc gcttttagcg cccgcagtac actatacttc 2093761 tcagtcgttt catagacttt cccttttttt cgcatacctg cagtatcgac aatgacaaac 2093821 tcctgctggt tgtaagtaaa tgacgtatca acagcatctc ttgtcgttcc agccacgttg 2093881 ctgacaataa cgcgttcttc gccgagcatc gcattcacaa gtgaagactt tccgacattt 2093941 ggacgtccga tcagacagaa ttgaataact tcttcattgt atttcgtttc aggaatgttt 2094001 ttaaaatgct ctgcaacggc atccagtaaa tcacccagtc cgagtccgtg tgttcccgaa 2094061 attggatacg gctcgccaaa gcctagcgaa taaaaatcat aaatattcgc tctcatttct 2094121 gtgttatcca gtttattaac cgctaaaaca acaggctttt ttgtgcggta caaaattttc 2094181 gccacttctt catcagcagc tgtcacgcct tcacggccgt tcaccataaa aataatcacg 2094241 tccgcttcat ccatggcgat ttcagcttgc tggcgaatct gcgctaaaaa cggctcatca 2094301 ccgatatcaa taccgcccgt atcaatcaaa ttaaaatcat aattcagcca ttcagccgag 2094361 ctgtatatcc gatcccttgt cacgccaggg gtatcttcta ctattgaaat tctttctccc 2094421 gcaatccggt taaagattgt ggattttcct acatttggtc tcccgacaat ggctacgaca 2094481 ggtttaccca tagtaccctt cctttcaatc cagccgcttt catttttaca taaattttca 2094541 accggttatt aaaatcattt cattcacttt tatgaaaaga aacccttcag aggaagggct 2094601 taactcattt attatatcag tttttactgg gatcacaact attcttaaaa atgtttcacg 2094661 atcaaataca cgtcatctcc gattctgtga gctattccat caaggatcgc ctcaagattt 2094721 ttagcgaaaa gctccatctc cttttggtca ttgcaaaaaa agacaggtgc tccccctgca 2094781 acccgatttc gatttgtcgt gattacagac aaaatcactt tcgtaagaga ttcactcatc 2094841 ctatcacctt atcctgattc ttgataaatt cagtcggcat tctaatcgca ttttccaggg 2094901 ttggaacatt gctaataatt tgaacagccg tttcgggatg gtgaatttgc gggagaacaa 2094961 atactgccac tctcccatca tttaaatccc gttttgcaat tggtgtcaaa gatggctctc 2095021 ctgaatcccg ataaaccccg agcacattgg aaacatcaaa taaaatggcc tgacgctgcc 2095081 ctaaatttgc tatcgtcgct gctgaattaa agtttttcgg cgtcaaaata aagcccatgc 2095141 catgctttaa aatcagttcc tgtttctctg gaagcccgat attcatcata taaatattat 2095201 caacaaacag tcccggaccg tcaaagcgcg gctttatgta ctcgatatct acaatatcct 2095261 tcaacacact gcccgacata aacttcatgg ccagtaaaaa acaaacgaca gccgctatga 2095321 ctgcagccca gatggataaa aacacatacg cagaggttgt caaaagcgct gtaaagatca 2095381 caatataatt tctgctttca aacgcaatgg caatcccctc aatatatgtg cttccccttg 2095441 agacaagttc atacgaatcc atttgcgtca atgtgttccg ctccatgttt cggacatctc 2095501 taaattgcgt cgctgccaat gttaaaaatg tgatggccgt aaattcctcc tgcaaaagcg 2095561 ccggcataat aattgcacct aaaccagccg ctatcaaccc cagtgcgatg tgaatcactt 2095621 tcccatgaac ataggtcgga tactggcggt aatccgtttt cagcatataa agccttgtcg 2095681 caattccggc aatgacccca gcaataatcg gatagatgta atcactcatg acattttggt 2095741 agctcctttg tttgatcttt tgcttttctg accaatctgg cttgcgaggt gttcgtattt 2095801 agatatgcca aacagcaata tcatccccgc agaacacgca ttcagccatt gaaagccgcc 2095861 gacagccata gccccggcca acttctggat cacaaatgaa tacaccagtt cgccttggca 2095921 catccctagg acaaataaga caagctgctt ctcaaaattc ctttcaacag aagctgttaa 2095981 aagcactatt aatataacag cagcccactc aggttttatg atgaaccaaa ccgggtcata 2096041 taatgcaaaa agataaacaa acgcatacgc ggcaacaagc gtcagataga ccatgatgta 2096101 acgaaaacga tacattccca aatacccggc atagacacat ccgcaaacga aaaacatcaa 2096161 atatgcagca ttcagggaaa aatataaagc gatgtcatgt atgcttagaa taatattagt 2096221 taaaataaag acagagacgg caattcgtct tttcgtcttt tcaaaaataa atgttgtcag 2096281 aacccacaga aaccacattg accaatagta ataaaattgt tccattttac ttcctccata 2096341 ttcccagtat ggagttcaag cacatttttt aaacaatcga tctcacatta aggagtatga 2096401 tcatgggaaa agacagacaa gagaaaaaac tcaaagcttc aggcagagtc gaatcagatc 2096461 gcgaccagtc cattcactat gacggagcga caagccttga acaaaacgga agattcaaaa 2096521 agcgaaaatc ataatacaaa aagcccaaac cacatatggt tttgggcttt tatcatttat 2096581 cgcacactat agcttgatgt attgacccct ctctctgtga gccaatgatg ggtttcacct 2096641 ttgatcacaa ggggcgcctt ttgtaaatcg gcaattgttc tggcacccag cacggtcata 2096701 atcaacttta attcctcaag gatcagctga atctcctcaa gcagtccttc ctcaccgctg 2096761 tcagtcagcg cttttaaaaa atgccctgcc attccggtgc aagaggcccc cagcgcaatt 2096821 gcctttgcca cgtcaagcgc atcttgcaga ccgccagagg cgatcatggt gcttgcagga 2096881 aactcagagc ggatttccgc caaacttgca gctgtcgaaa tgccccacga attaaaaaag 2096941 gagatttgcc gctgtcttcg gagattttcg attttcgaga aatttgttcc cccgtaaccg 2097001 ccaatgtcaa cagctgcagc accagcttca tacagctttc ctgctgatgc tttgctcata 2097061 ccgaagccga cttctttcac aatgaccggt acactgaccc ggctgcaaat ttgttcaatg 2097121 cgtttcaatg cgccgctaaa gcttctgtcc ccttcaggca tcacaatttc ctgaatcaca 2097181 ttgaggtgga tctgcagtgc gtttgctcca atcatctcaa cggcttcctt tgcctgagca 2097241 gccgttgcct cgcttcccag gttggcaaaa atcagcccgt ttgggttttc ctttcgaaca 2097301 atttcatagg aaagacgctc tgatggatct tttaatgctg acatttgcga tcccacagca 2097361 aggggaattc cagcctgaga agccgctcgc gcaagcgatt tattaatctc atatgtaagt 2097421 tttccgccgc cgccagtcat tgcattgata aaaatcggcg aactgcttga aagttcgccg 2097481 atttttgtgg aaatatctac ttgttctaat gcaagatcgg gcagactgac gtgaacaaac 2097541 gtaatatcat caagacctgt ttcccgcttc tggccgatgg acaaggcatg attgatgtgt 2097601 tgtctttttc gttctgctcg agtcacgttt atcaccaatt attttagttt attcagctta 2097661 tctccgatca gatctccaag ctggaagcca gtgcttgttt cttccttcgc ttgatattga 2097721 cggtaatctt cctggtcagc tttaggcgtt tcttcaagtt cacgcatgct taatgaaatg 2097781 cgctcctcat tttcattcac atcaagaacc ttcactttta cagtctgtcc ttcttcaagg 2097841 acttcatgcg gcgtgccgat gtgtttattg gaaatttgag aaatatgaac gagaccttca 2097901 acacctggaa ggatttcaac aaaggcaccg aagcttacaa gacgctgtac agttccttca 2097961 agcacatcgc caggcttcac tttttcgccg atttggttcc aaggtccagg cagtgtatct 2098021 ttgatcgata aagaaatacg ttcattatca cggtcaaccg ataacacttt cacttttact 2098081 tcttgtccct cttcaacaac gtcagacggc ttctctacat gagagtggga aagctgtgaa 2098141 atgtgtacaa gtccgtcgat gccgccaata tcaacaaacg cgccaaagtc agtcaggcgc 2098201 tgtactttgc catcaagtac acttccaact tcaagagact gaagaagttc ttgtttttta 2098261 ttcgcttgtt cactttcaac aacagcacgg tgtgaaagga tcacgcggtt tttatcacgg 2098321 tcaagctcta caacgagcag tgacagtgtt tttcctttat agtcagtgaa gtcttcaacg 2098381 aaatgtgctt caacaagtga tgccggaata aaaccgcgaa cgccgatatc aacgacaagg 2098441 ccgcctttca cgacatcttt cacttcagct tcaaacactt cttttgtttc aaattttttc 2098501 tcaaggtctt cccaagcgcg gtctgcatca acagcacgtt tagataaaat caaagcatcg 2098561 tcttccactt ttgttacttt caggtcaagc tcgtcgtcta ctttaacaac atccgatgct 2098621 ttctctacat gaagacttga taattcactg attggaataa taccggattg tttgacattg 2098681 ataatttcta catctacatg tttgtcttct acctttgtca caatcccttt aactacatct 2098741 ccaacctctg gcacttgaac atcaatttga ttcatttcct ctgtcatttg aataacctcc 2098801 ttggtccaaa cctacacagc ttaattaaaa cggtttgaaa gctgaacata taacatgccc 2098861 gcttttagcc gaatatgtat taaagaatca tccaaaaaag ttttttgaat gatcaataaa 2098921 aagttttatt agtattaact tctaataaaa ggacaggttt gtcaagcaat aacattctat 2098981 cttcgttgaa aaattcaaaa aaagtggcat ttgccatcct cagcgggact tttgctccac 2099041 agcctcgagg attttatcag ctacctcttg aatggaaagc gatgtcgtgt cgatttcaag 2099101 agcgtcttct gctttacgca gcggagatac ttcgcgctct gaatcaagct tgtctcttct 2099161 tgcaatttcc tcaattaatg tttcgtagtt gacatcaaag ccttttttca cattttcttc 2099221 ataacggcgt ttcgctctct cttccacaga tgccaaaaga aagattttta cttctgcatt 2099281 tggcagcaca tgcgtcccga tgtcacgacc atccatgacg acgccgcctt tttccccaag 2099341 ctgctgctgg cgtttcacca tttcttctct gacacttctg tgcttggccg caattgaaac 2099401 ttggttgctg atttcatctg ttctgatcgc ctcagttaca tcggtgccgt ttacaaacac 2099461 tttttgtcca tcttttgttg taatcagctc aatgtctgtc cgctttagca gctcagccag 2099521 tttttcttca tctgtcagat caacgttttc ctgtaaagcc gcgtacgtaa tcgcccgata 2099581 catcgctcct gtatcaatat atatgtacga ttttttctca gccacaattt tggcaacggt 2099641 gcttttcccc gcagctgccg ggccgtcgat tgcaatcgat aatttctttt ccataattcc 2099701 tctccttgct cttttctcct ctaaggattg tatcacgaac tttatgaaaa agggtgaaaa 2099761 attgatgaat aattaatgtt tgaaggtttc aatcctattg ttttcctcca ttttatccac 2099821 cccttcatat tgaatcactt ttgatacgta tggttcaata tgctgatagt gaaaaagaaa 2099881 ttggacacca agtaaaatga tggcctgaat gaacaataat ttgatcagca gccgttcaaa 2099941 tgttttcatt ggagcacctc cattacaaat agtatggaag tgtttgccga tgtttattcc 2100001 attcgggcct ttcttctctt atttaactgg cgcctgatgc agtattgaag caaagcctgc 2100061 tggtcacctg ctgcaatttc tgaatactct aaagtcattt ttcgtttttc tgacttgggg 2100121 tcattaaaga ttcgtctgac aactgcttct gtttctattt gacgtgtgtg ctcctcttca 2100181 ggaagacgga tgatcaggcg caatgattcc cccgattgaa aagaaaggcc atcagctaaa 2100241 accacggcga tgccgcctgc actgatgtta taggatagtg tgcggatctc ttcttcattt 2100301 cccggctgaa tttgcacatc taataccgca tcagttctta catattggcg gcgctggatt 2100361 cttttcattt tttcacgggg aggcatttca agacagatca tttgaagttt gtccttcact 2100421 ttacctttta tacggcttat aaagcgataa ggaacttcgt cttttcccac aaactctacc 2100481 gttacttcca tatcgttatg taaaatcaca gttcgccctg taactacatc aacaggatac 2100541 gcgatcaaaa gttcattgtt ttcgatgctg accgccttgc tttttgcctt tttcaattca 2100601 ttttcttcta tatattctaa aagtacattt tctccaatct ctatcattga cttcactctt 2100661 tcgcattcaa tatactcacg tttttattaa agcacgtaat gaaaaaaagg aaaagacatt 2100721 tagtcctttc ctcctgtttt tataggtctt tatatatagg ttctgcattt tttagttttt 2100781 caaccttttc ttccgatccg tctttggcat tgatatacat tctgaatgtg tcattttcaa 2100841 ttgtcccaag catttcgtag cataacactt cttgacctag ttcatttgta atcaaagcga 2100901 gccttgtttc tctcacttgt acatttttat ttaatttaga ctttgcctct gcttcagtaa 2100961 ttgcaggctt aggtatggtt ctttttctgt gagatgtgag gaagtctctt gctgaaaagc 2101021 cgacaacctc accgtcatcc aaggccactt tcatacgaat tgcctcgggg tacatccgga 2101081 ctttattttc aacaggaaca tatgaaaata caccgatttt atcatattgg gcactttcat 2101141 caatttccaa atcatctgtt tcaaatccgt ttttctttaa aaatgcaagc gctcggttcg 2101201 atccgtcatt taaactgatt ttctgatctt tcacttctct gttttggatc aagtataccg 2101261 gatgcccgcc cttcttcgta atatccatat aaatcactgc tttatggtct gggtctttca 2101321 tgctgatgct atatacatcg cgatttgttt tttttccgct ctttaccact ttaattgaat 2101381 aattgtcatc tggggcaaag cgctcagcaa tttgttttgc ttcctgttcg gaaatttgtt 2101441 ttcccttcag atggctgaag cctttctctt cttttttcgt actggtgaaa ctcgggccaa 2101501 gatcagtgcc agtggagaat gcaccaacat ttttttcgac tgttttaaag ctgttgataa 2101561 tcgtattatc actttgtttt tcgtcagaag ccagagccat ttctacgtcc atccagcgaa 2101621 ggtttttgct catgacaagg tgctgaacat gacgcaattc attttgtata tcttcggact 2101681 gctgatatag cttatttagt gatgtatact cgtttttatc aagcggcttt tggtccaaat 2101741 ctctgactga cgttttatag ctgaaatcgc cgatctttga taatagctct tcagttttat 2101801 taaacggcat taatgtaagc ggcagctgac tgacgctgtt atgagcttct gatgtaatcc 2101861 tccacacatc gatcaatgca ggcgacagtg atttttggct gttcatggca agtgttgttc 2101921 cgattttatc atgaagctga tccacctgat aggtaagctc atgaaacgcc cgctgatagt 2101981 tattttcagc atgaagaaga actgcgtctt tttcctggtg ttctttgtat ccccagtagc 2102041 ctgtaccgac tattgcaata ccaagcacgg cgattaaaat tcctctgatc atttatcaca 2102101 cctcttttta tgctttctca tatctgctac tcacagaaaa tgtgtttacc gattctttta 2102161 atctgcggac gcccccaaat ccacggactt gtagccgtat ccggattaaa gtagtaaagt 2102221 gcttcctctg atgggtccca gccattgatg gcatccagca ctgcttctcg tgccgtttca 2102281 ttcggctgca tgtaaatttg tccgtcggct actgctgtga aggcaagcgg ctcaaaaata 2102341 acccccgcta ctgaatttgg aaataacggg ctgttcaaac ggtttaaaat gactgctgca 2102401 atagcaacct gcccctcgta cggctcgccc cgggcttcgc cataaaccgc ttgagcaagc 2102461 agcctgatat cgttgttgga aaatccacca ggcatgttcg ctgctaccgc atcctgtttt 2102521 cttgcttttg ctggtgtatt gttttgctgt ttattcgcat tcgctttagg cttctgcgtt 2102581 gttttttccg caggctgttt ctgccgtgct tctgcttgtt gtcttgcctt ttgtgttgct 2102641 gcttttgatg gtttcgtctg atactttagc ggaatttttc cgtaatgcgt gaatgtattc 2102701 cctttattga gctgttccat gacatattca cgatagtatt ttgatttaca tattaaggtt 2102761 tgctttgttt tagctcctac aaggccgtca acctctttta acccgaattg atcctgaaaa 2102821 tttcgaactg cccagtacgt cccccatcca taaaccccgt caatttttcc gttataatat 2102881 ccgttgtatt gaagacgcgc ctgaagctcg accacatcat cccctgttgc ccctctttga 2102941 atgacctgat tcgaaaaggc agagatcgtt tcagtattaa taaacgtcgt tattgtaaag 2103001 gaaaaaagga tgagacatgc cataatcgat cctttggact tcatcttttc aagcctccta 2103061 ctgcaaattt ttaagtgtaa tcgtattttc tgtaacgagg ttatttttat acactctttc 2103121 cttgttatcc ctcagaacat aaaaactgca cacaaaaaag ccgcacggtt gctgtgcggc 2103181 ttctatactt gcatcatatt aacggaacgg gcttttttcg ctttacgcaa accaaaccac 2103241 cataaaaata ccataaatgg aagcatataa taaatccaat tgctaagcgc tgttaggata 2103301 aaatcatatg atccatgcaa aagggatggg acaactaaag aaagagtaag ccactttaca 2103361 cgcgccttat cagcggaaaa acgggctttt ccaaggtaaa atcccattat aacgccaatc 2103421 aaggcatggc atgaaacagg cagcagcgcc ctgacaaacg catgctccac gccgtggcca 2103481 attaaataaa gaatattttc gagggttgca aaaccgagtg atacacttgc accgtacaca 2103541 atcccgtcat aatgctcatc aaagtgggcg tgcgggtaaa cactgatcat cagtataaac 2103601 cattttaatg attcctccaa aaaccccgaa gataaaaaag aaacgaaaaa gcttccgcct 2103661 cctacattct ctttttcaag tacatactgg ataaacatga tgggaaatac aagaacaacc 2103721 ccgagaaaaa acgaccgtag caccatatgt acaggttcat tatcatactg atcttttaaa 2103781 taaaaataac ttaataacgc gatgccgggg gcaattcctg cagagatgat tgcaaacatc 2103841 aggcaacctc tttcctttat attcctacat ctatcctacc atgttgttta aaattttaca 2103901 tctgtctgca cttaaaaaaa caaaaagagc atacgaatgc atcatatgct cctcatcttt 2103961 aatggttttc tcttttggcg atttccgctg cgatatgccc cccgtgaaac ctgccgtttt 2104021 caataaatat ttcatttgca ttgtttcccg cagcaataac accggcaata aagacacctt 2104081 caacgttcgt ttccatcgtt tcttcgttga aaaatggacg ccctgtttct ttatcaattt 2104141 caacaccaat tttttcaaga aattgatgat cgggatgata gcctgtcatg gcaaatacaa 2104201 aatcattttt aatggtaatg agttctttct ctccggagcg aaacacaact tcattctcgg 2104261 tgattttttc gacacaagct ccaaattcca tacggattgt accgtttctg acgagagctt 2104321 caaattccgg cagaatccac ggcttaatgc tcggagaata ctcattgccc ctatataaaa 2104381 ctgtgacacg cgccccagat ttcacgagtt caagggcggc gtccacgctt gaatttttcc 2104441 cgccgatgac aacaacatct ttatcaaaat acgggtggcc ttctttaaaa taatgaaata 2104501 ctttcggcaa atcctcaccg ggtacgccca tatagtttgg atgatcataa tagcctgtgg 2104561 cgatgataca atatggcgtc gtgtaggtct cttttgacgt ctcaataacg aatgtgttat 2104621 tttgcgtttt cgtcacttta cgcaccattt caaacgcatt aacacggatg tttttccgtt 2104681 taacgacttc ccggtaatac gataaagcct gaattctgac aggcttcctg ttctctgtaa 2104741 taaatgccac atctccgatt tcgagctttt cacttgaact gaaaaaggtt tgatgcgtcg 2104801 ggtaattgta aatactgtta acgacattgc ctttttcgat gacgagggca tcaatgccaa 2104861 tttgttttag gtgaatggca gcagatagtc cacaaggtcc tccgcctata ataattgctt 2104921 tttcttgaat catttctgtc aactcctgcg attggcattt cacttcatat tttctatttc 2104981 cgaataaaaa aatctcctat tttatcatag gagatttttt atttttatgc aaatcatcaa 2105041 cttatatcca gcctctaaaa cgcgaagctt cagccatttt gcgaacgccg accatatatg 2105101 cagcgagcct catgtcaatt cttcggttgt tagccatttc gtaaatattg ttaaatgatt 2105161 tgaccatcat tttttctaat ttttcttcta cctcttcttc actccagtag aagccttggt 2105221 tattctgaac ccattcaaaa taagaaactg ttacgccacc ggcacttgcc agcacgtctg 2105281 gtacaagcag aatgtcccgg tctgaaagaa tttttgttcc ttcaagcgtt gttggtccgt 2105341 tcgctgcttc aacgacaatt ttagcccgga tattatgggc attttcttct gtaatttgat 2105401 tttcaatcgc agcaggaacg agaatatcac aatccagctc cagcagctct tggttggtaa 2105461 tggtatcgtt gaaaagcttt gttacggtac cgaagctgtc gcgtcggtcg agtaaataat 2105521 cgatatcaag gccttccgga tcataaagtc cgccatacgc atctgagatg ccgacaactt 2105581 ttgcccccgc atcatgcata aattttgcca aatagcttcc cgcgtttccg aagccttgga 2105641 caacgacacg cgcaccttta atatcgatgc ctctcttctt agccgcttct ttaatacaga 2105701 tggtaacacc ttttgctgtc gcagattctc tcccgtgaga tccgccaagc acaagcggtt 2105761 tgcctgtaat aaatccaggc gaattaaatt catcaattct tgaatactca tccatcatcc 2105821 aagccatgat ttgtgagttt gtaaatacat ccggtgccgg cacgtctttt gtcgggccga 2105881 caatttggct gatcgctctg acataccctc tgctcagacg ctccagctct ctaaacgaca 2105941 tatcccttgg atcacaaaca attccgcctt taccaccgcc atatggaaga tcaattatgc 2106001 cgcattttaa actcatccaa attgaaagcg ccttcaccgc cttcacctct ttttctgtta 2106061 cgttcgggtg aaaacgtatc ccgcctttcg ttggaccgac agagtcattg tgctgcgcac 2106121 gatatcctgt gaaaatcttt actgaaccgt cgtccatacg aacaggtatt tttaccgtta 2106181 ataatctcat cggctctttt aacaattcgt atacctcttc gggatatccc aatttttcca 2106241 gagccttatg tattacggtt tgggttgatt ttaatacatc aagtttgtcc tcttctgtat 2106301 gaccggtgtt tcgatcggct gccatttgag ttaacctcct agaatcttct gtttctcaca 2106361 tgctcccttt cagagaatag tatacacctt catatgatct gtgcatagaa taaacgttat 2106421 gtttttccat gttttttaac gaaaaaaaac tgctgaaatc agcagttttc cgttgcattc 2106481 ttatgaaaaa tgagtttgta tcgtttctac ggcattaccg tccataatga gcttaccata 2106541 ctcttgcagg cgataaatcg ttaaagttgt cggattgccg tattcagcca gaaccgccac 2106601 aaccccttca gccgtatgtg accctagatc ttcaaggctt aaaaagtact gcccgtcata 2106661 gtggtagaca gttccccctg tgataccgat tcgctgtaag ctttctgaaa gctgaatgat 2106721 atcttcaaag gaatggaatt gatatatgat gtccgcgctt tcatcaagct tgacttgcat 2106781 ttcgatgtaa tcatcatcat actcatcgtc ttctgaatcg gcgtcttggt tctttgttac 2106841 aatcacgacc atcccttgtg cttggagaga atacacttcc actgcaatcg gtccattcgc 2106901 ttcaaagccg agctctgtat ttgcttcatt catcatatct ttaaataact ggtggacttt 2106961 aaatgagtcc ttccagaggt cttcttttgt caatccccgg tctgtcaaat catcgagggt 2107021 taaaaagatt ttgatcttat tataattcag acgctcaagc cgcataacgt tccctcctgc 2107081 ctctacttgc acacaaatca tataacacat tatatgagat gatgagtcat aggttcttaa 2107141 ttgttatcag tttacactga gttcactagt aagacaagca caatgcagtt tttattgcca 2107201 tacggatttt tgctttttag aagttattct ggcccgcaaa gagtcacaat gtgagtttca 2107261 ggctcagcac ctaaacgaag aggcactttt gtcgtgccgt agccgttgct gatcagatat 2107321 gccgcgtttt taacaatacc tgttttcccc agttcataag gaccgaattt tccaaacctg 2107381 atctggcctc catgggtatg tccgctgagt atcacatcaa taccgtcatc ttcattgatt 2107441 tgttcatgaa tctccggatt atggcaaacc agaatattca gctggctttc atcaagttct 2107501 ttgatggctt cctcataatg atccatctcc atcctgatat catcaacccc cgcaatcgca 2107561 atcgtatgcc cattgtatga aaacgggact gactcatttc tcagagtgat gacgccgtgc 2107621 gctttaaata tggaatacag cttatgctgc ctgacttcat aatcattatt cccccacaca 2107681 aacacgatag ggaccccgaa atgtacgagc cttttgatgt tttcctcgat tctcgcactg 2107741 ggcaccccgc cctcagctaa atcaccgccg attataacca agtggggggc atggcttcgc 2107801 gctttttcta aaaggtcttg atcgatgaga cgtttgtgaa tgtctgaaat aaaaaagatt 2107861 gtcagaggcg gcttgccctt catctttgat aaaggaaacg tatgtgtctt caaatgattg 2107921 ccttttgctg ttgcatacat ttttgccgtc attgccgctg ccgcaacagt tagtacaccg 2107981 gcaattttca ctgatagctt cataaaaaac tctccattct ttttagaact tatcaataag 2108041 acggacaata aaaaaagacg tttctatcgt ttgagaaaac gccccatttt atttactttc 2108101 aaaatataga ttaatgtcat atttgtgctt catcatatga aaaacagact ctctcgcctt 2108161 ccatttatcg ggctgcggcc agagatcagt gcttttctga ataatttcac atctcagttt 2108221 atggaaatca gtctcggatt tttcttcctt tttcttgaaa taatatgaag tgcagtaggc 2108281 aaaagcggtt gccagcatcc aaaataaata aaaggtatgg ctaagtattt cttgaagtat 2108341 aagctgaggc tccgggcttt tgatcatgat cataacacat aataagccta ggcagataag 2108401 tgaagcccat cgccatctgc ggcattgtgc tgcataattt tcgaattttt gttttcgttt 2108461 taccagcgct tggagcatct gtttggtcgg cgcgtctgta aactgatcca gctgattcca 2108521 taaggattcc atacgcttca caccttgtcc attttcattg ctacaatata tgaacgtaaa 2108581 ataaaaataa taccctattc atccattaaa gggatgtcca aaacttgtcc ggtgtaaaca 2108641 tcatttccat tcagatgatt atatgctcga attttttctt ctcctgtccg gcttttataa 2108701 tacttcatgg aaatgcggta tagcgtttct ttcttttgga cggtgtgctt gacaacgcga 2108761 ttcggcacat tttgaactgg ctcagctggc tgttcttgct gttgtactgt tgattgggaa 2108821 gaggaagcag ccgcggcggt tgcttcctcc ttatttggcg agtcttcttt ttccgctaca 2108881 gcagtctgtt tcttatcagc agctgtttgc tcttttggct tggaatcttc tggctctttt 2108941 tttgactcct tctgcagtgc ggtttcttta gtgtctgcgg tatcgttttt atcctctgat 2109001 ttcgggacaa cctcatattt gctttggctg ctgtcaataa aaacatcttc ataatcgtca 2109061 tgattatccg ggtggctctt tagataaaat aaggtgacta aaacgataac cggcacaaat 2109121 acaaatatta ctgcgagtac tgtgaataat ggcgtttttg ttttgccttg cttttttttc 2109181 tgttctcttt gattttttac agattgtctt gtcggaaggc tttctccatc atcgacataa 2109241 tcgtccgcca atgcggcgtt ttgatcttca taaagattct gggcttttct tctctctact 2109301 ctcgacatgt tcgtcatgtt tatccctcct cacatgttca aaacgaatct gacaggcaaa 2109361 cacggcatca atgataaaat gcgccgtcat cggaacaaat aagttgccgg tccattcata 2109421 catcagaccg agcaaaaagc tgattgctgt caccataata aataacagcc attttgacaa 2109481 ataccgaaag tgcagagcgg caaatataag gctggccgtc cataaaccga tatgagtctg 2109541 cagcactcct ctgaataaca tttcttccgc gaaagcaatc agaagcgtta aaaatataat 2109601 atgagggatt gacctcttac tgaatatttt tttattgatt ccgccgtcat catataaatg 2109661 agacggaaac catttcatta ctgccatatc ggctaaaata acaataacag ctatagaaac 2109721 accataccag atgattcgca tatcgcgaat gtcccagagc tttaatacgt cccgtacatc 2109781 ctcaaaaaag aacagtcctg ctgcagcagc ggcaaagatg atgagtagct gcgtcaaata 2109841 taactgcttc agcatatcat ggtcagtcat atgctgaata taatcttttt gctgtttcag 2109901 ttcagctcac ctacagtctg caagctgaat atccggtgca attccgaact ccagctgtct 2109961 aatggcgcca ttttactccg ttcccctttt tgttcataca aggataaatc aaaaccgcaa 2110021 tgtgaacagc acgggaggtt tccgtcatca ggctcgtatg attcatcaaa gtaggttaac 2110081 agtgcctgcc ttaaacagcc gtcacgctga agcaaaaatg atacacggtg cattttttcc 2110141 agcttcagct ccatgcgata tgaaatttct ttcttcatca gttcaactga tgtttttccc 2110201 tgcataaaga gatgaatcat catacgggcc tgtgtctctc cgacgccata ctgaagtaat 2110261 acgtcacgca gccttctctc atcccgctcc tccgtcttct ctagcacacg gattacgtcg 2110321 gcgatttctt cagctgtgac actctccatc tggataattt gttcctgcaa ttcaaaatcc 2110381 cctggcgccc gcagcaaaat gctgacactc ggctttccgt cgcgtcccgc tctgccgatt 2110441 tcctgcataa aagcttctgc cgtctgcggg agatgaaaat gaatcacata tctgatatca 2110501 ggtttatcga cacccattcc aaacgcattc gtacaacata tcacatcaag ctggttatga 2110561 ataaactgct gctgaattaa aatcctgtcc cctgactcca aaccgccatg gtaaaagtcg 2110621 gctctgctgc tcgttttgct tttaatttca cccgctaatt ccttagccca tttccgtgtt 2110681 ggacaataaa caattcccgg accttgcagg ttttcaacca gctgaatgac cctatctatt 2110741 ttttcggcag tatccgccgc attttcaacc ctcagtgcga tgtttgggcg gttgactgag 2110801 ttgagatggc gtacagcatg ctgcagctcc agcaggttca tgacatcttg cagcgtttcc 2110861 tttgtagccg tggcggtcaa tgccagaacg ggtgggtgtc caagtttttt tctcagctgt 2110921 ccgagctttg aataatcagg cctgaagtcg tgtccccatt cagaaataca atgcgcttcg 2110981 tcaataacaa ataggctaat cggaacgctt ttcaattttt ccaatacata tggagactgt 2111041 aaagcttcag gagacaagta caaaaattta tatcgatgaa tatgttctaa aacaaattgt 2111101 ctttcctgcc tgttaagcat gctgttcaaa gctgcagcac gcttttcccc ccgggctttg 2111161 agctgctgca cctgatcctc cattaaagaa agcagtggag aaacgattaa taccatgcca 2111221 tcaagcatat aaccaggcag ctggtagcaa agcgatttcc ctcccccagt cgggagcatt 2111281 gcaatggtat ccttcccgct gagtatgctt tcaataatgt cctgctgccc ttttttaaag 2111341 gaagtaaaac caaaaaactg atataacgtt tgctgtaatt tagtcatatt gctgcacctg 2111401 ctttgtcaat gccagtctga tttgaaagta gctgaaccgc tgttccagcc cgtcgcgaat 2111461 ttgtttgatt ttattcgtcc gcatccgttt ggcaaactct gcgatttgaa gctggtcttc 2111521 tgctgataca tagtcattaa tcataaacgc aggctcatgg agagaaatct cgacaatgtg 2111581 gtcttcaatc gtcgctgttt tcagctttct gatttcagca attcgctgta tcggaaaccc 2111641 ttgtttgacc atctgccatg ttttcctcgt cgactctgtc agggcattat ctaagtgcac 2111701 atcagaaagg agatccttta acaaagcatc ttcacactcc ggaagagaat gaataaaata 2111761 atgtaccgaa gcccaaaaca tgatatagac ataccattcg tcttctttca gcgtatcagc 2111821 aagctgcctg ctcgtataac cgatccgatg gtgcgaggtt aaggagtaga caaaaatttg 2111881 cgctgctttg ttttcaatct ttttcaaatg cgcctcaagc atggcaaaaa ggctttttgc 2111941 catctctata tgatccgtat gccgggacag gtatttcttt acccagtgaa gtgtcttatg 2112001 atcctttgtg acagggatat actgcctgct cccttgctgt ttatgggata ggacctgcac 2112061 aagcagcgaa agccttttcc aaagcacgcc ggcagcctgc tgataatgag cgccgtgaca 2112121 atgaacgggc caaggccgct cgctaagggc atgtctcaaa actgctgcgc cgctggctgt 2112181 cactttgtat gtatctgatt cagacattgg cgcgagatat gaatgctttt caagcttgtc 2112241 aagcgacgca gaaatatcgc ttctcgaaca ttttgccgcc attccaaagt attttgcagt 2112301 ctgaaataag ccggcatctt gaatggtctg tgacgatctc ttgcctttga ataggtgaaa 2112361 aacagcgctt cccgaccgtt ccccgtttat tttgcaaaga caatcgagaa ccataatatc 2112421 gaagtaattt aatgacaacc tatccaccta cattcttcct gacaaaaatc gttgatttgc 2112481 tctttttatt ttaacagatt tcaaacagaa atcgacgttt aaagtcatca ttaaggggga 2112541 tgttatgtag ataacccctt atgtgataag cattctcaat catttttctg ttgaaatgtg 2112601 gcagcaacat cattacaata agtaagagga ataggtgtta aattgattaa atataaagat 2112661 tgatccattt gttccaccaa gaacaatctg ggaggtttta ttcatggcaa agtacacaat 2112721 cgtagacaaa gatacatgta ttgcatgcgg cgcttgcgga gctgctgcac cagacattta 2112781 cgattacgat gatgaaggca tcgcgttcgt aacgcttgat gaaaacaaag gtgttgtcga 2112841 agttcctgag gtactggaag aagatatgat tgacgcattt gaaggatgcc ctactgattc 2112901 catcaaagtg gcggatgagc catttgaagg cgacccgctt aaatttgaat agaagtaact 2112961 aaaaaaagct cccgaacggg agctttttta tttaatggat atgtgcactt cgctgctgct 2113021 caatccatgg cttaagcttg ataaaaatta gtgagaatac aaccgtaatt acaatacctt 2113081 ttatcatgtt aaacggcagg atacctgcga cgactgctgt ttttagcgcg ctgtcggata 2113141 atgccggtga atgtaaaaac cacgtgtatg ccggaagaat cagaacataa tttaaaatac 2113201 tcattaaaat ggtcatcgct gcagttccca aaagcaggct gacagccaag ccctttgctg 2113261 agttgagttt tttaaataag aaagcagtcg gtaatataaa gagtgttcct gcaataaaat 2113321 tcgcaacttg ccctacagga actccggcca tgcttccctg aatgatatac tgaagaacat 2113381 tttttatcgc ttctacggca atacccgcca aaggtccgta aatcagaatg gcaataattg 2113441 cgggaacgtc gctaaaatcg atttttaaat aatccggaag acccggaaac gggaaattta 2113501 acagcatcaa aacaaatgca atgctgctca gcatgctgac cacaactaat ttttttactt 2113561 tcacttcatt ctctcctttt cgatcacatc ttactcgaaa acggaaaggt tcttttccag 2113621 ccaataaaaa aaccgcttca tatataaaag cggggtttcg aaaattaggc taggcaaaga 2113681 aacgtttgaa aaattcaatt tcaaaacgct tatgaacctc catcttctcc catccagact 2113741 gtactgtcgg ctccggaatc tcaccgaatc ctgctgtaaa gacagctcgc gggcttagag 2113801 ccattggctc atcaccgccg gtagggaatt tcaccctgcc ccgaagattg atcatatgaa 2113861 atttaattac attataaacg ataactggtt ggctgtatag agaattgctt caaattaaat 2113921 atattacctg caagctgtca gatcattgat ttattaggct ttacttttat cctttactgc 2113981 gtcaatacac gttgacactc ttttgagaat atgttaaatt atcagatatt tagtttgtca 2114041 atttaggagg aaatctaacg atgtttcgag tattggtctc agacaaaatg agcaacgacg 2114101 gtttacagcc acttattgaa tcagacttta ttgaaatcgt tcaaaaaaac gtagcagatg 2114161 cagaagatga attacatact tttgatgctc ttttggtgcg aagcgcgaca aaagtaacag 2114221 aagacctttt caacaaaatg acttctttaa aaattgtcgg aagagccggt gtcggtgtcg 2114281 ataatatcga tattgatgag gctacgaaac acggggtaat cgtgatcaat gctccgaacg 2114341 gcaacaccat ttcgacagct gagcatacat ttgcaatgat ctcttcttta atgagacaca 2114401 ttccgcaggc taatatctca gtgaaatcca gagagtggaa ccgcacagct tatgtcggtt 2114461 cagagcttta tggaaaaacg cttggtattg taggattagg ccgaatcgga agtgaaattg 2114521 cacagcgtgc gagagcgttc ggtatgactg tgcacgtttt tgatcctttc ttaacggaag 2114581 aaagagcgaa aaaaatcggc gtaaacagcc gtacatttga agaagtgctt gaaagtgcgg 2114641 atatcattac cgttcacacg cctttaacaa aagaaacaaa aggcttattg aataaagaaa 2114701 cgattgcaaa aacgaaaaaa ggcgttcgct taattaactg tgcgcgaggc ggaattatcg 2114761 atgaagcagc acttctcgaa gctttggaaa acgggcatgt tgcgggagca gcgcttgacg 2114821 ttttcgaagt cgaaccgcca gttgacaaca aacttgttga tcatccatta gtcattgcca 2114881 ctcctcactt gggagcatca acgaaagaag cacagctcaa tgtcgccgcc caagtgtcag 2114941 aagaagttct gcagttcgca aaaggcctgc ctgtcatgtc agctatcaac ctgcctgcca 2115001 tgacaaaaga tgaatttgct aaaattaagc cttaccatca aattgcagga aaaattggca 2115061 gccttgtatc acagtgcatg aaagaaccag tacaggatgt tgccattcaa tatgaaggca 2115121 caattgctaa acttgaaaca tcgttcatta caaaagccct tctgtcaggc tttttaaaac 2115181 cgcgcgtaga ctctactgtt aatgaggtca atgccggggg tgtcgcaaaa gaacgcggca 2115241 ttagcttcag tgaaaaaatt tcctcttctg aatctggata cgataactgc atcagcgtaa 2115301 aagtgacagg agaccgcagc acctttactg taacggctac gtatattcct catttcggag 2115361 aacgaattgt cgagatcaat ggatttaata ttgattttta tccgactggt cacttggtgt 2115421 atatccagca tcaagataca acaggtgtca tcggccgagt aggacgtatt ctcggagata 2115481 atgatattaa cattgcaact atgcaggttg gccgtaagga aaaaggcgga gaagccatca 2115541 tgatgctttc ctttgacaga catctggaag ataaaattgt gaaagaacta acaaatgtcc 2115601 ctgatattgt gtctgtgaag ctcattgatc tgccataatt aaaaaaactc aagctatata 2115661 gcttgagttt ttttattgtt ctatccccgt gtgtttttat gcaaaatatc taagacactc 2115721 cttagctcag aaacaggaat ttggcctggt gcggacgcct cttctccagc tccaaaagta 2115781 caagccgatc caaaaacctc accgctcagc ctgctgatga gccctgttgc agccattgac 2115841 attgtaataa tggggcggtc tgcatatatt gttttcattg tatacgtcgc atcaagcagt 2115901 gttaggagat ctccagtatc attcggcatg acagccattt ttggaatatg cgcgcctaag 2115961 tcctgcattt ttcgaagtct ggaaataatt tcatctttta caggtgtttt ttcaaagtcg 2116021 tgatttgaca tcaccacata gacgttgttt tcttccgcca gcgatactaa cgcttttaca 2116081 tttgcatctc ctgaaaataa ttcgatgtct atcagatcga tgtcttttgt ttggattgcc 2116141 gattccagca aagcaagata ggagctttcg tccatctcca tgctcccgcc ctctttgtgg 2116201 gttctgaatg taaatagaaa tagcttgtct tctaaagatt tacgaagctt agaaatgagc 2116261 tttgtgaccg cttctctgtc attcgctttt tcaaatacgt cgactctcca ttcaacaatg 2116321 tccggattca gtaattttac tgcctctgct tcattcagaa tttgtttttc cgtctttccc 2116381 atcagcggaa tgatgatttt cggcatccct tccccgatgg aaactccttt aatcgttaac 2116441 acgttcactc gtctcaaatc ctttcaatct ttaccttgtt ttattataca cgtacaactt 2116501 ttttttgaaa atttctatta tatgaatagc aactaaaaaa gagccttaaa gggctctttt 2116561 tagtttaagg aaatcggatt tggagcagct ggcaccggaa ttgcatctga tatgtcatat 2116621 ttgccgattt ttttcgttct ggtttccgta aaggtcactt ctgtgaagcc aaactctttt 2116681 gcagtcaaaa gtagtccctc aatcattaaa ataccggcaa tagaatcatc aacttctgac 2116741 tcctttgaaa agcggatata taagtgtttc tgtttcttcg ttacagattg gacagcaccc 2116801 gcttgaataa gaggtgtcgt atcttcttgg ctgctcgatt ccatttcctt aatcgcttct 2116861 tttactgtat caaaagaatg atttgacgga acgagaaagt cttgtccttg tttattttgg 2116921 tacaagtagt aggatcgttt tgactgtttg ggaatcgaaa tttccgtaaa agtgccatat 2116981 gagccaatcc gaaccccagt ctcattttga tccgataaaa atttgacttt ttcataagga 2117041 ctccatttta aggattcttt aagcaatttt tttaacagtg tatcatcttt tatagaaaat 2117101 gccgtagctg gctgatggac tcgtatactt aattccttct gctttggttt ttcctttatt 2117161 tctacttcat ctatgaaggt tggaattgta atggcatgat caaggatgcc caattcacta 2117221 ctttcaaaca gcatatcctg gatcgtttgg tctgcatttg ttttttgaat gctgacgggt 2117281 atgattgcag atgtatcggc atcagcaacc gctacagtga tgtaattgtc ttgttccttt 2117341 tcaggaacga caaacgatgt ctgatccaag gacgatgcag cttttgggct gtcttctgtc 2117401 tcagttttcg ttactgcgtt ctcttgggac gcttcttttt gttgaggctg tgcctgatca 2117461 aagaaatgag gagaaataat gaaggcgata taaaccgcaa ttgcagcggc acacgcgggg 2117521 ccaatccacc tgacagcggg cttattttta cgctttgcca tcgtcagccg cttgtaaata 2117581 tcctgaggcg aacgatggtc tttaactgcc ggaagttgac ttaacaactc ctttatctgt 2117641 tcttcgttcc attctgactt catcatccat tagctcctcc ctcaaaagct ccatatgttt 2117701 ccgaagtact ttgagccctc tgtgttgggt cgtttttact ttgctttccg agaagcgcag 2117761 agccttggct gtttcctgta ttgaatatcc ctgaataaac cgcaagataa tcacagctct 2117821 ttgatcgatt gtacattgat caagcgcagc ataaatttcc cggacatttt catgttgaac 2117881 cgcaagttcg tccggcagca attgctgatc cctgacatcc tgtgtatccc agtcaaatgt 2117941 accgagtata cgctgtctga ttgtttgctg tttacggaac cagtctatcg caacatggcg 2118001 tgcgatagac aaaagccatg ttttttcact gcttcttcct tcaaacgtat gataagaatt 2118061 taatacccgg atataaacct cttgaagaag gtcttctgtc tggtttttat cctttaccat 2118121 ataaaataaa aattggtaca aatcttgatg atatgtatca tataataatt gaaaggtttc 2118181 ttccatttga aacccctccg ttcacttttt tgtcgtatga atagcttgaa aagttacatt 2118241 acaactatat tacgagtaac tggaatttgg aagggaattt atattaacat atccttaaat 2118301 tttattaatg ttggctatta aaaaaacacc cgctcagtca gcgggtgttt cttatggaac 2118361 aagattcttc ggcaaattca gactcgattt taccgttttg tcggaatata aaaagaaaat 2118421 gttgttcctt tatctattcg gctgtgcaca gtaattgatc cgttgtgggc ttccacgata 2118481 tttttaacga tagccagccc taacccggtt cctgctctgc cccttgtccg cgctttatct 2118541 gccttataaa accgctcaaa gataaatggc agatcttctt ccggtatgcc agacccggag 2118601 tctttgatat caattttcaa tccatccttc acagaatgga ctgaaatgga gacactgccg 2118661 ccggctgaag tatgccgcag cgcgttatca atcaaattgg taaatacctg ctccatcttg 2118721 tcttcatcaa acataaattc ctcttctgtg agagaaatgt catgatctaa agcaatattt 2118781 ttttctttcg caacaccgga aaacttccga atgatctttt ctaaaaactc attcacattg 2118841 attttttcat aatgtaagcc tgtatggcct gattccattc gggctaaatc aagcaaatca 2118901 ttaactaaac ggcccattcg gagcgattcg tcataaatga tttgggcaat ttctttccgg 2118961 tcttcttcag agcttgcaat gtcatcgaca attgcttcac tgtatccctg aagcatggag 2119021 atcggtgttc tcagctcatg actgacattt gcgataaagt cctcccgcag cttatcaagg 2119081 cggcgttctt ctgtcatgtc acgcagtacg gcaaccgctc ctctgacgtg cgattccgca 2119141 taaagcggcg acatcaaaag cacccatgat ctgccttgaa gcgtcatctc aatcatttgt 2119201 tctttttcag tgctgacagc gttttgaaac agctcttttg cttcaggcgg aagattgtcg 2119261 ccttctttga tattcatgtt ctgttcataa taccaagcct gaagaaaacg ttcagccggc 2119321 gggttggtca caagaatcgt accgtcaata ttaatggtaa taaccccgtc agccatactg 2119381 ctcaaaatgt tagaaagctg ctctttttct tgattgagcg cattgatatg aaagttaagc 2119441 tgccggccca tttgattaaa agcggtcgcc agttcaccga tttcatcctg agttaaaatc 2119501 gggatttttg tatcgaactt gcccttcgcc aaatcctgcg cgccttctct catttttcgg 2119561 agagggtacg tgaccctgct tgataaaaag aatgcgaaaa atgtggtcag cacaatcgca 2119621 attccagcgg caagaaaaat atagcgggtc gtatgttttg ttgtatcttt aacggcaagc 2119681 aaagactggg ataaaaagac catgcctttc tttccgtctt tttcatacgg gacacctaca 2119741 atcaggcgtt cattatccgt gtctgtatcg ctcagtcccg tccgtttgct tactttttta 2119801 tggtctttga gagctttatt taagtctttg tcatgctgta tttgctcaac cgtaatagac 2119861 gacaggcgat ttttatcatt cggagaatac cagtggttct tctcatcctg gatgatggca 2119921 atgcttgtta agttatcagc gagttcccaa gtgattgacc ttgccagtgc ctggtcctcg 2119981 tgattttcta ggatgacagc aactttattc gcaagctgtg ttaaatcatt ctcagcttct 2120041 tccacatggt agttttcaat aaactccagc aaaagaaccg ttaaaatgaa caatacgatc 2120101 aagacgagtg aaaggatcgt aaaccacagc ttgcctacta cgcttttcca aaatttcatt 2120161 cagcgccgac ctcaaattta taacctacac cccatacggt gacaattttt ttcgcagctt 2120221 ccggagatac cttgttcagc ttctctctca agcgtttgac gtgagtgtcc actgtccgta 2120281 aatcaccaaa aaactcatat tgccacactt ctttcagaag cttttcccga tcatacacct 2120341 tgtcaggcgt tttcgctaag aaatatagaa gctcatactc ttttggcgtc aggctcactt 2120401 ctgttccatc agctgttacg cggtgagcat catggtctat tgacagatgt gaaaacacga 2120461 gcacattttt cgtcggtgta ttggcattga aataagaggt ttgggatgct cttctcaaaa 2120521 gggcctttac acgcagcacg acttctctcg ggctgaacgg cttaacaata taatcatctg 2120581 ttcccgcttc aaacccctgc acccggtttg cttcttctcc ttttgcggtc agcataataa 2120641 tgggtgtcgc ttttttttca cgaatttgcc ggcacacttc aattccatca gtccccggca 2120701 tcatcagatc aagcaaaatt aagtcataat tggcttcaag ccctttggca atggcttcat 2120761 caccattttc agcttcatct atagcataat tttcacgttc aagatacatt cttaaaaggc 2120821 ggcgaattct ggcttcgtca tcaactacta atatttttgt ttcgttcgtt tggtccatgt 2120881 tttccccctg ctttccttct gttactttca ttttatcaaa tcgtgagaaa gtttgagaac 2120941 tgtgtcgctt tcaaaggact atgcataaga atgaagtccg gcaagcacaa gatttacgaa 2121001 tattaaatta aacataataa tagcaaaacc gattacggcc agccatgctg acttctcacc 2121061 gtgccagcct cttgacagtc ttaaatgcaa gtaagcggca tagaacaaaa atgtgatcag 2121121 cgcccatact tccttagggt cccagcccca aaatctggtc cacgcgagct gagcccaaat 2121181 cattgcaaag atcagcgcgc cgagtgtaaa gatcggaaat ccgattgata cggccctgta 2121241 cccaacctca tccaccagat caagattgac gtttttcacc agcggatgta atagagcgct 2121301 gattcttttt ctgatgatca gacggagagc cccatacaac acaagacctg ctccaaatga 2121361 ccaaatgaca gtgttcactt ttctgcctga gaaaagcgcg ggaagatcaa caagcggttc 2121421 cattcttcct tcggtcaaaa gctctccctg atgcggaccg acaagcgcgg gcatttcgta 2121481 caccatcacg cttttttctt tacttttgtc cacccagtta aactccgctt catagcctgc 2121541 aagacgaaat gccgatgtga ttgcaataaa ggcgacggtt gtgaccagga taaacataat 2121601 cgcttcaagc cagaaggtct ttttgcttgg ctttgtctgg tctacatgct tcaaaagaaa 2121661 gatgacacca gcgacaaagc tgatggcaag tatagcttgc ccaagcgcgg ccgttgttac 2121721 gtgaatatac agccagttac tttggagcga aggaattaaa ggcgagatat ctgtcggaaa 2121781 catgctggcg taggcaatca gcaataaagc aattgacagc gtaaacaggc ctaatgaagg 2121841 caatctatag agaaaataaa gaatgataaa cgccaaaaca agcatcatgc caaaagcggt 2121901 ggtgaattca aacatattgc tgacaggcgc atggccgctt gcagcccacc ttgtgatgaa 2121961 atatcctagg tggcagaaaa aaccgacaat agaaagggtg attccaatgt tggcccatcg 2122021 gtttggcctg ccctttttat ctttattccc gcgtatggcc ccgccgaaga ttgggacagc 2122081 gattaaatac acaagaaagg ccgcataaag aaaatttccg ctcagctctg ccatgacatc 2122141 actccctttt cgcctatttc tgtgttttga ttaattcttt ttggtccacc ggttcagtca 2122201 gtccggaatc agccaatata aatgctaaat ccttcttcag gccaaaccag tttttattgg 2122261 tatgccctgc taccataact gcaccgtcct gtgagtgcag ccaaattctt cgatgctgcc 2122321 agtacatacc ttgaatgaca ccgatcataa aaatggctcc gccgacagca agcacccaga 2122381 gtgtcagatc ctttctgact gtaagtccag taatgttttt cgtttcgaca tggtcaaatt 2122441 tcagcttgta tttattattg cctgatcctt cgatggtttc ttggatggcg acaaagctct 2122501 tttcgccttt cggtttgtcc ggcgttatga tattaaagac aaaagccgga ttgttaggga 2122561 tctttgtttt tgtgctcggc tctccgtcct gattaaaata gaagtcaggc aggtagctgg 2122621 cgatttccac cttgtaaccg ttaccaagat catagactga atctggatcc agaaggttga 2122681 tcttcaggct cccaaaggat ttttttgttt ttttatcaat cagctggaac accatttggt 2122741 caagctgatt ctctttgtaa tccacctggt aaacggaaaa agaatcaaaa cgcagcggct 2122801 gattgacacg gatgtcttct tctgttactt tttccagctt cggcttctcg ccataaacaa 2122861 tttttccttc tctcttgtag agtacggcat cagtttgaaa gttctttgcc actctaccgt 2122921 ccccgactct gtcaatggca tctgcaaata cctttttttc cgttttgctg ttataggtct 2122981 ctacgctgaa ttgattgttt ttcaaataat attttccgtc tgtacccgga attgctgcgg 2123041 tttcgccttc tctgacccaa agcgtctcat cgacgtacat gccaggcaca aatctcagca 2123101 tcgcaccaat cagaaagatg atcaatccaa tgtggttgac atacgggccc cagcgggaaa 2123161 agcgtccttt ttcagcaaga atgctgccct ctttttctct gattctataa tgttttttct 2123221 ttaatagagt aactatcttt tctttcgatt ccccgttcag tacagtaact gtttcactga 2123281 acaagcgctg ccttcttaaa aaggccgggc tccttctgac accttggttt tttaacgctc 2123341 tatacaacgg aatgacccga tcaaggctgc aaatcacgag tgaaatgccg atcgaggcaa 2123401 tgagcagcaa ataccaccaa gaaccatata aatgatgaaa cccgagcaaa taataaagct 2123461 ggccaaacgt gccgtactgc tccttgtaat aagtatcagc ctgtgcgccc ggaggcagat 2123521 aggcttcctg gggaaaaatg gtgccgaacg ctgatgcggc aagggttatg acgataagcc 2123581 atattcccac cttaaccgag gaaaagaaat tccaaatttt gtcgatgatc gttttgttat 2123641 aggtttgcga acgtcttgcg cttccgtcat atctcatatc agcgagcgga ggttgagttt 2123701 cctgaagagc tcttccgcac gattcgcata aaacggttcc gaccgggttt atatgtccgc 2123761 attcacattt gacttgcttc atcccgaagt ctctccgggt tttatgagat tcatataatc 2123821 gtgtatcatg ctttctgtca tagtgccggt caccaccttg acaacttttc cttccggatt 2123881 gatcaaaaag gttgtcggaa gcggagatac gtcataggca tcaagcactt ggcgatctgt 2123941 atccagaaca accgggaaat tgactccgta ggatttcata aaattatgta ctgctatctt 2124001 tgactcccca acatttacag cgacaatttc aacaccttgg cttttaaaat gcttatattg 2124061 gtttgccata taaggaaact cttttttgca cggttcacac catgtacccc agaaattcaa 2124121 aaaaacacct ttccctttta agtcactgag ctcgatacgt ttcccattcg tatcctctag 2124181 gacaaaattc ggtgcgtcgg acccttcgga tatactctct ttgccggcaa atacagcgtt 2124241 gtaaatggta tagccgagtg cgcagattaa aacgagaagg atgccggtcc gaatgaataa 2124301 acgccttttt ttcttcattg tccactgccc ccttccccct attgcagatc cattcaatta 2124361 tatcattgca cgttcatttc acatttctta ctttttgaag gttatgtgaa atttagaaag 2124421 cgtttttacc gtgatccgcc agtgctctga gcctttttac ttcgtgaggc gtaagctctc 2124481 tggcatcgcc cgtgtgcagg cctcgcaggt ttaaaaacgc gtattcctca cgcttcagct 2124541 tgattacctc atgtccgatc gcttcaaaca tgcggcgcac ttgtctgttg cgtccctcat 2124601 ggatcgtcag ctgaataatg cttgtctgct ttttcttatc caaagacagc agcttcgctt 2124661 tagcaggcgc tgttttgcct tcctccagcc taattccgcg ctccagcttt ctgagcagct 2124721 ctttaggcgg gattcctttc accttcgcca cgtatgtttt gtctatttca tacttaggat 2124781 gcattagctt attggcgaat tcgccgtcat tggttaaaag caaaagaccg ctcgtatcat 2124841 agtccagacg cccaatcgga taaatgcgct gcggaatatt tttaaaaaag tccgtcacca 2124901 ctttgcgtcc tttatcatct tgcgctgcgg aaataacgcc tcttggttta tataagagaa 2124961 agtaaaccgg ctcttcgcgt tcaaccttta acccgtttac ctcaatctga tcagaaccgg 2125021 tgaccttaac acctagctct gttactactt tgccattcac ctttactttt ccttctttaa 2125081 tcagctcttc tgcctttctg cgcgacgcaa ctccggcatg agcaatcact ttttgcagtc 2125141 tttccatgtc tttcacctca agtattatct tacttttttc aaccttaaca aacaagcttt 2125201 ttcaaattcc tatgccaaat ctaaaaaaaa cgccgttttc aggcgctccc aaataataac 2125261 gtaacgatga tgatagatgc aactacgccg attaaatctg caagaagtcc cacctttaat 2125321 gcatcaccca tttttttaat gccgactgct ccgaaataca cagtcagtac gtaaagcgtt 2125381 gtatctgtag atccctgcat gacggaagcc agcctgccga taaaggaatc gggcccgtat 2125441 actgcaatta aatcggtcgt cattccaagt gcggccgtac cggagatcgg gcggatcaga 2125501 gcaagcggca ctacttcagc agggatgccg atagcggaga aagccggttt taaaagatcc 2125561 attataaaat caagcgcgcc tgatgatctg aaaacagtta tagcgacaag cattccgact 2125621 aaatagggga taatggaaaa ggcaatttct atcccctctt tcccgccttc gacaaacgat 2125681 tcatatgtcg gaaccttttt gatcgttcca taaagaagaa ttccggcaat aatgattgga 2125741 atcatggcta aagacagcca gttgatgatt tccatccgct caccttccct tctttttgcg 2125801 gcggtaataa aaataccgat caatgataat ggcaccgatt ccggaaataa gcgttgccaa 2125861 aatgcttggc ccgacgatat ctgtcggcgt tttggaggaa taagccattc ggacagcgat 2125921 caccgttgtc gggatgagtg tgatgcagga cgtattaaca gctaaaaaag taatcatcga 2125981 ccggcttgct tccgatcggt ttccgttcag ctttttcatt tgttccattg ctttaatgcc 2126041 aagcggagtt gctgcatttc cgaggccgaa gaaattcgcc ataagattag ataaaatata 2126101 gcccatcgcc gggtgatccg gcggtatatc agggaacagt ttagatataa aaggtctgca 2126161 catccggctg aaaatatcca aaagccctga ctgctcggcg attttcatta agccaagcca 2126221 gaaaacaagc acgctcatca atccaaatga gatcgtaatc gcttctttcg cacccttaaa 2126281 cacggcttca tttacatctt gcagagttcc gttgcacatc gcaaaaacga gtccgatcac 2126341 ggttaaactg acccaaatta tattgaccat tttgctccgc ctgccgcatt cagaaagatt 2126401 gatttaaacg tttcaaaaaa ttgtttcttc ggtttttgat gccgctcatt ttcataatag 2126461 atcggcactt ttgcgatggt tgcatcgttg aacatgatct ccatgtgccc tacgatgtca 2126521 gggattttcg aggcatcttt ttcccatgct tttttcggct tgagcagtgt ggtattaatt 2126581 tttacatttt ctttttcctc ttcggtcagc aaataggtga tatcacgttt gataaaagcc 2126641 ttcgattcat aaaatgtgcc tttcagcttt ggaatatccc ctttttttgc aattaaatag 2126701 gtttgataat gctcaaacac atagttaaac atcttcatat ggtcatccca atcattaggg 2126761 tcattaatgg tgacggctat caggtcaatg ccgtcctttg aagccgtaga gaccagtgtc 2126821 cgttttgcaa gttttgtata gcctgttttt cctcctgtgc tgtacggata aagcatggtc 2126881 agcagtttgt ttttgttttt ccatacgctt tccatcgttt ccgctttgta tatttttgtg 2126941 cctgaaatct tttgatagtc tttcagcttc atagcatact tagttaaaat ggccatgtca 2127001 taggctgttg aataatgatt ttcatggtcg tccaatccgt gcgggttttg aaaacgggtg 2127061 tttttcatac caagctgctc ggctttttga ttcatcatat aaacaaaccc atcgaggctc 2127121 ccaccgacat gctcagcaat cgcgacagcg gcatcgtttc ctgatcttag catcaggcca 2127181 tacacaagat ctttcagctt cactttttga ccttctgtta aataaatggc ggagccttct 2127241 gttctgacag catttgccga aaccgtcact gtttgatcca ttttgccgga ttcgatggcg 2127301 aggacggcgg tcataatttt tgtgatgctc gcgatccgcc ttttttgatg ctcatccttg 2127361 gcatataaca ctctgcctga cgcaccgtca ataatgatcg cgctttttgc actgacatct 2127421 atagcagcat gtgctgtatt cacatttacg gttgcaataa gaaaagaaat catgatcacg 2127481 aatactgctt ttttgaaaat gcgcatgttt gctcacgtcc ttgtggtggt ttgtacaagt 2127541 ttatgcgcat gtccatcagt tatgaataac aattatattt ctggaagcaa acataaaaaa 2127601 actctccctg aaaaagggag agtaaacgtt atctgattgg cgccatgctt gatccggacg 2127661 cttcgtaatg agccagctct tccctcatct tcagaaaggc cgcgctcaac ggcaataata 2127721 attgctcaag cgacgcagga acagcatgat aaaactcaat tgcgctgacc ccggtataag 2127781 acgcccggct attttcacac cacgtgtctt ttttcggcat aaagaactct tcaatgcatt 2127841 ggtgatacac attataaagt gttttttccg ctctggcttc ctgaaaaggc tcctgcatca 2127901 ggagacgacg gcacgcttct gcgcctcctt cacaaaatac tgccattctt ctcagagtgc 2127961 taagcacatc acagcagtat cctttttcaa taggcaattc agcctgtaag gactcaagcg 2128021 tcgtttgatt taggtaatcg ttcacggtat tgacaaccat tgataagaat tcgcctgttt 2128081 tttgagtctg cgctcgcaca atcgaatgtc ccatttcgtt tggtatcttc ccctcatgta 2128141 tttgtctctc acattttgct tctttcatga tagcttcttc cttatatctt atgatgatga 2128201 aaaagcgcga ttcattaaac ttctatttta tatcttcgaa ggtttggtta aagttttcaa 2128261 aaaataaatc tgcttcttct tgaagaacgt cttcttccgc attttcaggc agcggcggaa 2128321 gctcgtccag cgttttcaga ccgaattgtt caagaaaagt cggcgtagta ccgtataaaa 2128381 tggcccgccc cggaccatcg gcacgcccta cttcacacaa tagcgccttc gcgacaagac 2128441 tgtgtaaaat ccgctctgat tttactcctc tgatttcttc aatttctgct ctcgtaattg 2128501 gctgtttgta tgaaacaatg gccagtactt ctaaagatgc ttgagaaagg ccctttgacg 2128561 gcacttcaat cagttttttc aagtaaggcg caaagtcttt tttggtagag agcatgtacg 2128621 tatctgcata ctcaataagt tcaatccctc gtgtatctcc gcggtattcg tccgccacat 2128681 ccgccatgat cgtgttcagt tcaggctctt cgatttcaag cactgttaac agctgctttt 2128741 ttgtaagccc ttcatcgcct gccgcataaa gaagggcttc cacaatagct ttccaattca 2128801 cgatatcaag ccccatgaat ggattcactc cccgtaatgt aaatatctga aaaattgtgc 2128861 tcctgttcaa tgaggaccag ctgatttttc atcagctcaa gaacagctag aaaggtcact 2128921 actaaatgtt ctttttgctc atatggaaac agatccataa agttaattct cgttcctcta 2128981 gatttcaagc tgtgcacgat ttcgttcatt ctggcttcga ttggtatgtc ctgtcttgta 2129041 attgttgttt ccatcggcct gtttattttt ttgcgtttca gcactttttg aaaagctccg 2129101 atcatatcat agaccgtgac agagagcttt tgctcagact gttttacttc ttttgcatat 2129161 tcactcaaat cactcggcgg tttcgtgaac gatttttgtc tttcttcttc ccgttctttt 2129221 aaatccttcg ccgcatcttt atattttcgg tactcaatca gcttttcaat cagttcctcc 2129281 cgcggatctt cttcttcaag taattcatct tcaaaaagct cctcctcttg cttcgggagc 2129341 agcattctgc ttttaatgct gagcagcgtg gcagccataa ccaaatactc gctggcaatg 2129401 tcgagctcaa gcacgcgcat cgtatgtaca tataataaat attgttcagt gatcttcgcc 2129461 acaggtatat catatatgtc aatttcaaga cgattgatta aatgaagcag caggtccaat 2129521 gggccctcaa acgtatcaat tttcacttga tattcttcca tcatctcacc attttcaagt 2129581 atcactctca ttgccggaaa aactggctac cctatagtat aagccaccaa aaagctctcg 2129641 tccaatacta tttcatatcc tgttttgaag gagtttgtac agaatattca aaacacaaga 2129701 ggtgtttgct cggagcgcag aagcgggaga aaaagccttt gcttctggtt ttcctttcta 2129761 agaagcacta gaggccgggc gttctttttt ccttttatcc cttctatggt acactaaaag 2129821 cacattaaag gaggaagcac cttgtatccg aaagcttata tagattatct cgttgagttt 2129881 catgcgacac gggattattt tgaatgccat gaaatattag aagaatattg gaaggaagat 2129941 ccgccaaaga aacgaaaacg ctattgggtg ggctttattc agcttgcagt ggctttatat 2130001 catcacagaa ggcagaatac agccggggca aaaagactga tggcgaacag catccggatt 2130061 cttcaagcag aacaccgggc agtcgaagac ttagggcttg atcatggccg tttgctcgaa 2130121 cttatgcaat cggtttacga acaaatcgaa accgtctctg cctataaaag cattatactg 2130181 ccaatcaaag atgagaaact ggaggaagca tgcaggatcg aatgcaggaa aaaaaagtat 2130241 acatgggggc agcccagtgc actcagcaac atatttctta tcgacaaaca ccgtttgcgg 2130301 gatcggactg acgtcatccg tgaacgtgaa aaagaaatag aacgcagaaa aaaaagcaga 2130361 gactgatcac agcctctgct taattattgt atgaaatgtc ttgatcctgc tgaccttgac 2130421 aacgttcgaa aaagctctgc gttaattcat ttggaaccag tacttgcgtt ttgaataaat 2130481 gctttaaagc atccatcatc tgttttccga ttccttgatg gcgatgagaa ggattcacac 2130541 tgatatgccg gatctcaacc tcagaatcct ttttttcgac tccgattgct ccgacgatat 2130601 cctcgtcctc tttccaaaga aagagctggc ggtctgtatc cgtttcgtag tccttaattg 2130661 tctgctgaag ctgcttaagg tctttttcat tcggcataaa cgaaagaagc cccatcgcaa 2130721 tcttttcaaa cgatttttta taacgaatta acataaaaac ccctctatat ccaaaatgtc 2130781 cagtctgcta ttaacggata cgaataggtg atccgttttc tcacattata tcattttcgc 2130841 catattttta aactgttttc agcaaattat tcaaatgagc ggtttaaatt tgccatttca 2130901 atggcagaaa cagcacaatc tacacctttg ttgcccgctt ttgtgccggc acgctcgata 2130961 gcctgttcga tgttttcagt tgttacaatt ccaaagatga caggtacacc agtagtgttt 2131021 gctgcttgcg cgatgccttt tgcagcttca ttgcagacat aatcgtaatg tgtcgttgcg 2131081 cctctgatga cagtgcccaa tgtgataata gcatcatatt tttttgtttc cgccattttt 2131141 ttcgcagcaa acggtatttc aaatgcgcct ggaacccaag ccacatcaat gtcatttgtg 2131201 tctacgccat gtctgagcag cgcatcttct gctccgctca gcagcttgct cgtaataaaa 2131261 tcattaaatc ttcctactac gattccgatt ttaagacctg taccaactaa atttccttgt 2131321 atgatattca tatgattccc atcctttttt gtgatatttg tgattagaaa tgaagtaaat 2131381 gacctagctt gttcattttg gtttgcaaat attttttatt gtgttctttc gcctccattt 2131441 gaagcggcac tctttctgaa atactgagtc cgtagccttc aaggcctgcg atttttcgcg 2131501 gattattcgt caaaagcttc atattccgga caccgaggtc gcgtaaaatt tgtgctccga 2131561 tgccatagtt gcgaagatcc ggcaagaatc caagcgcctc attggcttct acggtgtcat 2131621 agccttgttc ctgaagctta taagctttta atttattgat taaaccgatg cctcgtcctt 2131681 cttggcgcaa gtacaggagc actccacggc cttctgcggc aatttggttc agcgcggcgt 2131741 gcagctgcgg tccgcaatca cagcgatgag agccaaacac gtcacctgtg agacattctg 2131801 aatgcacccg gaccaatacc ggttcttctc cgaacggcac atctcccatc acaaatgcga 2131861 catgctcttt tccatctacc tcatttgtgt atccataaac cttaaatgtc ccaaaatcag 2131921 taggcagcgt aatgtcaact tcacgctcga caagtgttgt cagattgtaa cggtattgaa 2131981 tcaaatcctt aatggtgatc atttttaatt gatgcttttt cgcaatttca atgagctcag 2132041 gcactctcgc catcgttccg tcttcattca taatttcaca aatgacgccg gctcctggag 2132101 atccgcaagc ttcagcaaga tcaacagcag cttctgtatg gcccgctctt ttcaggacac 2132161 ctcctttttt cgcaatcagt ggaaaaatgt gccccggacg ctgaaaatca gatggcacgg 2132221 atttgctgtc cagcaatgct tgaacggtaa aagatctttc ttgagcgctg atacctgtct 2132281 tcgtttcacg atggtctatg cttacggtaa atgcagtgtg gtgagagtct gtattatgct 2132341 caaccatagg gtgaagatca agcctgtctg cgatttcctc actgagcggc gtgcagatca 2132401 gtcctctccc atgtgtcgcc ataaagttaa tgacttccgg cgttgcatgc tcggcaagag 2132461 ccacaaagtc tccttcattt tctctgtctt catcatctac aacgatgatg acttcgcctt 2132521 tttttaaagc gtccagtgct tcttctatcg gatgaaacat gcaaatcttc ctctctaaaa 2132581 gccgttttcg cttaagaagg cttttgtaat ggtttgttgg gtcttatttt cattggcttt 2132641 atgcaaaaat cgatacatat attttccgat catatcgcat tcgatattca ctttagagcc 2132701 gatcgttttt tctgaaaaga tcgtttcgct gatcgtatgc ggtattaagg agatcgtcac 2132761 tgtgtcttct gtcaggccga atatggttaa gctcacgcca tccacagtaa ttgatccctt 2132821 taaaaccaat gtttttgtta atgacgggtc catttttaaa tcatagtaaa ctgcgttgct 2132881 tttctcttca attcgtgtga tttccgcagt tccgtcgaca tggcctgaga cgaaatggcc 2132941 tccgaaacgg ccgtttgccg ccatcgctct ttccagattt actttgcttc cttttgttaa 2133001 atcattcagt gacgtagctt tgactgtttc aggcataaca tccactgtga attgattttt 2133061 tgtaaaatca gtgacagtca gacaaatgcc gttcactgca atgctgtcgc caagatgaac 2133121 atcctctaaa atctttgagc atttaatagt taaggccatt gcatgccctg cttttttcat 2133181 ggattcgatt gtgcctgttt cttcgataat tcctgtaaac atggtcacca tcctattcct 2133241 ttgtcggttt tgccgtcagt ttgatatcac ggccgatttg ggttatatca gtgaattgta 2133301 ataaggggac atctttcatt gattgaaaac cttcaccgga gattaagctg ggagcatgcg 2133361 ttcctccgat tagtttaggg gcaaaataga agatgatttc ttgaaaacag ccttctttga 2133421 caaagcttcc gtgaacagct gaaccgcctt ccacatacac cgacatgatg ccttcttccg 2133481 ctaggatctt caaaacatca ggaatttgaa tgcgctcggt ttcaagtgta aatatgttca 2133541 ctccgaaagc tgaaagccgt tttttctttt cctcgtctgc gcgtgccgtc gtaaaaatcc 2133601 atgtcggcgc tatttgatcg caaatcactt tagcgtcctc aggaatcgag agtacggtat 2133661 caagtatgac ccgaaccggc tgttttgtta cattcggcag tctgcaggtt aagctcggat 2133721 tgtcggcttt cactgtgcca actccgacta aaatgctttg gtgtgttttc ctgtattgct 2133781 gagcatcctg tcttgcagcc tctgacgtga tccatttgct gtcacccgtg ctggtagcta 2133841 tcttgccgtc aaggctggca gccgctttta gcgtgacgta cggaaggcct gtcctcataa 2133901 agtgcagaaa tttttcattc agcctctccg cctggtctgc caggatgcct tcccttacct 2133961 caatgccagc ttctttcatc atgctgatcc ctcttccagc cacaagcgga ttaggatctc 2134021 tcatcgccac gaacactctt ttgataccag agttgataat caattctgca catggcggtg 2134081 tttttccgta atggctgcac ggttcgagtg taacgtaaat gtcggcaccc tctgcatgtg 2134141 ctccagccat atggatggca tgaacttctg catgagcttc accatatttt aaatgggcgc 2134201 ccattccgac aatttgtccg tcctttacga caacagcgcc gacgagcgga ttggattcgg 2134261 tctgtccttc gccctgcttc gcaagatcta aggccagctt catataatac tcttccattt 2134321 gtttccctcc cctcttttgt tatttaccgt caaaaaagcc ccgaatttat aaaaaattcg 2134381 gggctttagg tattttacgc aataggaaat aacactatgc atttttaaac attttgcata 2134441 gcggctcatc atccttctcc catccagact ttcactgtcg gcttcagctt aaactgaatc 2134501 caccgcgtgc ttatgcacac gggtcacggg ctctaaagca aatgtgcttt actaccgccg 2134561 gtcgggattt ccaccctgcc ccgaaggata caatctttat tcatttgtcc ttattggtta 2134621 ttatagcgat cctttttaaa gtacgcaatg aaataaactt acaatttgag aaaaacaaaa 2134681 catcaccctt cgatccgaaa ggtgatgttt tttaatcatt cacttttgca accttgatta 2134741 atccgtcgat ccgctttgat ttgctgaagt aagccttaat cttgtcacct tcttttatat 2134801 cagataaatc ctgatttaat ttttttccgt tgaagatgat tttcgttccg ttttctgcta 2134861 ctccatgata ctctgagccg tcaattttcg tcactttata ttcctggatg gtgtattcct 2134921 cttcttccga ggacaaggtt tgtccaattg ctgtcggaac atccttcagc tcaatatcat 2134981 ttatgtacat ataaccgcct gcaagtaaaa gcaaaagcac taacagaatg gtaatcttgg 2135041 tttttattct tcccatttct aaacctccag ccaatatgaa tctattcatt catatgagtt 2135101 attccttttt ttcatgaata aaaaaccgta aattctcgta aattattaat ataacgatgc 2135161 ataacgggaa tatgtttcac atttctgcaa aaatttcttt tctatagata tacgaattta 2135221 tgttctgttt ttaggggatg accgtaaaaa agatataaaa aaagcagccc caatgggaag 2135281 ctgcttgatc ctaatttgtt ttgcgcattt cgttaaacgg gtagaaaaca aactttgacg 2135341 tacccgcaat ttgttttttc gtgaagaggc caaggccgtt acggctgtcc atggaattgc 2135401 gacgattgtc acccatcaca aaatacttgt tatcaggcac tttaaccggg ccgaaatcat 2135461 cggtcaaatg gtcaaaaccg tcctgtttcg ctctcttttt attagccgcc aaataaggtt 2135521 cgtccacctt tttcccgttg atatagagct ggtcattttt catctcaacc gtatcgccgg 2135581 gaaggccgat aatacgtttg acatagtgaa catcatctcc gtttaacacg acgatgtctc 2135641 ctctatcaaa ctcgccgatg tatttgactg tcatattaac aaaaaccctt tcacggttgt 2135701 gaagtgtagg atacatagag tcaccatcaa cgacatacgg cgcaaaaata aagttgcgga 2135761 tgagcaaagc aagaacgaca gcaatcacaa ttgcttttgc ccattctaat attgactttt 2135821 tcttcgaaac attttctgat ttcaactgat ttcctccaat aaacaacggt cttcaattta 2135881 tgttatcacg aatcgaaaaa aaatcccatt aggaccattg aagtgatttt acaaactgtt 2135941 aatcttcatc ttctacccac atcatgccta ttttttcttg tcgatcataa ctaggcctga 2136001 aaatattgaa agaaatgaat cgcataattc agaagcgatg gactcagaag aaagagagtt 2136061 ctcatatgca aaatctttag atcgtatata aagcatgagg ttacgggcag tttgttcatt 2136121 tactgcattc cattgatctc ccagtccatg atacccatgg cacttgacaa aacaattaac 2136181 gtcatgaagg ttactggaat gtttgcggca acctatttca caggtgataa ccgcaccccg 2136241 ttttttgctt tcataatatg tttaaaatca ttcaagctcg aaaacatgga tcagcctcca 2136301 aaaaataaat ccaatatatt cccggcagtt gaagactctt tattataaaa ctctgaatat 2136361 ccgcagttct tacagtaaac cactagaaat cggttatgct gcacgtcaaa cagctttgat 2136421 aatcccgtgc cggttgtagc tatttctttt tgtccggctt cagtactacc gcattttata 2136481 cagcctttgt tgttcatatc gcgatctcct tttcattaca tcacgtttgt ttgatttatt 2136541 ttactacaaa atatcaatcc caatgacccg tactacttta aagtttactt aattttgatt 2136601 acatactaat tgggttcgtt tctcagcttg gtaaatcttc tggagaaacg gaaaagctcc 2136661 atgaccaaaa cattcaaact cagccaaaca ccgccgaagg cgtaacccgc agcaacatca 2136721 ctcggatact gctcataaag tacacacggc tcagcccgat gaggaataaa acgataataa 2136781 acaaaaaaat gcaacagttt gcagacgcgt cttgtgagaa tgacgaacaa aaagataagc 2136841 acaaaaacca aaaatgacaa atgccgttaa agtctgttcg ctcgggaatg gatataatac 2136901 atgactttcc aaaggagcgt gaacaggatg aagggaatga aagagccgtc tgattccctc 2136961 ttcataaagc tccccaccaa tgactaggaa aaataagaaa gagagttcga ttttccgatc 2137021 ttgccctctg aataccgtcc aaaaaaaagt tagaacaata acggctaaca gaacacctct 2137081 cgacgcaaaa gctttctgaa ttgcagctgg gcccagtcta tacccgatcc aatacgacat 2137141 gctcactccc acagctcccc aatccggccg ctaacatgct tagcacccag tttaactttt 2137201 cttgaaacac gagaacaccg gcaaactctc ccggtccaag taaagctaga agctctaaca 2137261 tcaagacaat aaacaagacg gcatatccgt actgttcgag caaccccgtc aaaacttgca 2137321 tgtgattctc cttaaacttt tttgttcttt tatcattccc aatccacttt ttgtataatc 2137381 agcacaattt tatcttcagt cgtccaacaa cattgtctat ggcgggatct tctctcatac 2137441 attctttttt gacataggag gagcaatagc atgaaatggg aggaaacaaa agatacgcag 2137501 ggagtttgcc aaaattttgg gcagttcgtt ctgccaccga gtcaggtgtt tgtttgccca 2137561 cctcatccct tgtcaattcc ccatttttcc cgtttgaggt tcgaaatggt aaagtatttc 2137621 acttagtttc ttacatgaag aggtaaattc tttgctcacc gaactaggat agcggcgtat 2137681 ggcgatttct acattgcata accactggtt atttagtgag ccgtgagcaa tgtatatgca 2137741 ctttgagtca gcacaggatg atcctattac attcgccaga aaagcagctg ccgcattcag 2137801 agtagttaaa agaatagaca gatatctggg cttccggaag ctttaaagga ggctcttttt 2137861 tcgagcattt ttataaatca ataaaaacag gcatctccta aatatttttg ccgataagtt 2137921 tacgctaatc aactctagca ctaatacata taaaaaatag aatgatatga aaggagactt 2137981 gatagtatga ttgattatcc tattaatata aacaacgttt ccgggaacag tgtaattaac 2138041 gtaggcggcg cttttatgat caggccttta actttgtcca aatctgtgtt tggctccgga 2138101 ggtttaaaca caggaattgt ctttgaaaat aactttgtaa gcaaagctaa aatgattaat 2138161 catcaattta ctgatcaaaa cgtcaccaaa actttttaat gtattcaata cacgggggtc 2138221 actaactaaa cacctggttt tgccaaccgc catcagcatt cggcggtttt ttattgaaca 2138281 tttttggcca ataaaaaaag cttcctctct aagaggaagc cttttgcctg ccgattagcc 2138341 ttctacacga acttctttca tgacatcgcc attagacatg tttttcgcga attctaatcc 2138401 gcttgttact ttaccaaata cagtgtgaac accgttcaaa tgaggctgtg gctcatgaac 2138461 gatgaaaaat tggctgccgc cagtgtcttt tccggcatgt gccatagaaa gtgcgcccgc 2138521 ctcatgtgta tgcgggttgc cttctgtttc acatttgatt gtgtatcccg gaccgcctgt 2138581 accagttccg tgcgggcatc cgccttggct gacgaagcca gggatcactc ggtggaatgt 2138641 aagcccgtca taaaagcctt cgttcgcaag cttttcaaag tttgcaacag ttccaggtgc 2138701 agcttcagga taaagttcaa attcaatttt gttcccgtct tctaataaaa agtaacctgt 2138761 tttcaattgt atgcctactt tctttatttt aattttcaaa ggagattatg tataggttat 2138821 agcctgtctc tccttgtcgc ggctattata ccacaccttt cgggggaaaa cgaatctccc 2138881 gagctttact aaaaaataaa aatgaaacct gaatctcttt atctccgtct aacctaacgg 2138941 aactgtattt ttcatgattc aggtcctcac aaagcagcac tatccagctg cttgtgaaat 2139001 tgaaggaggt caaactgctt tgaagaaaat ttggattgga atgctggcag cggccgtttt 2139061 gctgctgatg gttccgaagg tcagtctcgc ggatgccgca gttggagatg tcattgtaac 2139121 actgggtgct gatttgtcag aatctgacaa acaaaaagtg cttgatgaaa tgaatgtccc 2139181 tgataatgcc acaacggtaa ccgtgaccaa taaggaagaa catgaatatt taggaaaata 2139241 tatatcgaac gcgcaaatcg gatcgagagc gatttcttca tcgtcaatca ccattgccaa 2139301 aaaaggctcc ggattgaatg ttgagaccca taatatcagc ggcatcacag atgaaatgta 2139361 cctgaatgca ctgatgacag ccggtgttaa agatgcgaag gtgtatgtta cagcaccgtt 2139421 tgaagtatcc gggactgccg ctttaactgg attgattaag gcgtatgaag tttcttctga 2139481 cgaagcgatc tcggaggatg ttaagcaggt cgccaaccaa gagcttgtca cgacatcaga 2139541 gcttggagac aaaatcggta acgaaaatgc ggcagccctg attgcaaaaa tcaaagaaga 2139601 gtttgctaaa aacggggtgc ctgataataa agctgacatc gaaaaacaag tggatgacgc 2139661 agcttctgat ttaaacgtca cacttacaga cagccaaaag aatcagcttg tctccctatt 2139721 caataagatg aaaaacgctg acattgactg gggacaggtc agtgaccagc tagataaagc 2139781 gaaagataag attacgaaat tcatagaatc agatgaaggc aaaaacttca tccagaaagt 2139841 cattgatttc ttcgtatcta tctggaatgc gattgtatct atattcaaat aagaaaagcg 2139901 ccgaaaaatc ggcgctttct tttattgctt tacacccgtt ttaaatggca gatcaagttt 2139961 tacaatatct tcgtatgttt ctcgcttcac gactaaatga gcctcaccgt tttcgacaaa 2140021 tacaacggcg ggtctcggaa tacggttata attgttggcc atgctgtatc cataagcgcc 2140081 tgtacaaaaa acggcaagaa gatcgccttc ttttacttcc ggcaggtcaa tatcccaaat 2140141 cagcatatct ccgctttcac agcactttcc ggcaattgat accgttttgt catgcgcttc 2140201 tccgatcctg ttggctgccg cagcttcata tttagcttgg taaagcgcag gacgaatatt 2140261 gtcgttcatg cctccgtcta cagccacata ttggcggaca cccggcactt ctttttgaga 2140321 gccaaccgta taaagagttg tgcctgcgtc tcccacgaga gaacggcccg gttcgatcca 2140381 aatttccgga atgtcaaaac cgtaacggga agcattttct ttcacagctt cgataatttt 2140441 ttcaacgtat tcagtggcat gaagcggttc atcatcttcc gtataacgaa tgccgaaacc 2140501 tcctccaaga ttcagcacct tggatacaaa tgaatatgaa tctctccatt cgtctagttt 2140561 tttgaagatt ttttccgctg ctaacacaaa accggccgta tcaaagattt gcgagccgat 2140621 atggcaatgg acacccagca gctgaatgtg ttccgattgt aatacttgtt caatggcccg 2140681 ttcagtttgt ccgttatgaa gatcgaaacc aaactttgaa tcttcctggc ccgttgtaat 2140741 gtagtcatgc gtatgcgctt ctactccggg cgtgatccga agaagaacat cgatggagtg 2140801 acccgtttct ttacataggt cttcaagaag cgcgatttca tagaaattat ccaccacaat 2140861 gcagccgatg cggtgctcaa gcgccatccg cagttcttcc ctgctcttat tgtttccatg 2140921 aaagtggatg cgttctgccg gaaagcctgc tgcaacagcc gtatatagct ctcctccgga 2140981 tacgacatct aaagaaagtc cctcttcctc agcgagctga atcattgcga ctgatgagaa 2141041 tgctttgctc gcatatgcca cctgtgcttt cagccctgca gaaataaacg cctgcttaaa 2141101 gcttttagca cgctcacgta ttaaagccac atcatatacg taaagaggtg taccatattt 2141161 ctccgctaaa tagagagcat ccacacctcc gatttctaaa tgaccatgtt gattttgtct 2141221 gcttgtgccg tgtaagaaca atgtcattcc ctctttctcc gcttatggat gaaaggacag 2141281 ttttatggac tgtcccttca taattaagac atacattatc atactcttca gtcagtttca 2141341 atgcgattat gaattggtag gctgccttaa gcgatttttg gggtgaacga tgctgggtct 2141401 tacttttgcg ccaggtttcg ctgtgcggac aagaacctgc cacagcgcct ttccgttaaa 2141461 gggaatcagc ggccataagt acggtgtctg aagggatttg atgcttgcca tggcaataat 2141521 tagcactgta aatccgatga cgagcccttt tatatgaaat aaagcaacga gtatcatgag 2141581 gacaagacgg ctcattttgt ttgccaagct taattcataa ctaggcgtcg taaaggttcc 2141641 aatcgccgca agtgagacgt acagaatcac ctcaggagaa aaaaggccga cctcaatcgc 2141701 aatctgcccg atcagaacag cggcaattaa acccattgct gtcgataaag ccgtcggtgt 2141761 gtgaatggca gccattctga gaaactcgat tcctaagtca gctaaaaata tctgcaggat 2141821 gatcgggata tgcgtatctt tatttaaacc gataaatttc atgttgtccg ggagcagatc 2141881 aggctgaagc acaaagagaa accagatcgg aagaaataaa gtagaagcaa gaataccgaa 2141941 aaatcttacc catcttaaaa aggtcccgac tgaaggcgcc tgcctatatt cttcagcatg 2142001 ctgcacatgg tgaaataaag tcgtcggggt aatgatcaca ctcggcgatg tgtccactat 2142061 aatgataaca tggccttcta gaacatgatt tgcggccaca tccggtcttt ctgtatagcg 2142121 cacgagcgga aaaggattat agctttgatt aacaatgaat tcctcgacag ttttgtctgc 2142181 cattgttaat ccatcgacat caatggatgc aatttctttt tctacgatct caaccagatc 2142241 cggatcagct atatcttcta tataacaaat gcttaaatcc gtctttgacc gctcaccaac 2142301 tttagtcatc ttgactcgaa ggcgttcgtc tctgatccgc cttctgagaa gggccgtatt 2142361 gacgacgata ttttcaacaa atccgtctct ggctcccctg accacctttt ccgtatcagg 2142421 ttcttccggg tttctgcccg gatagcttct gacatcaatt ataaatgcga agcctgcacc 2142481 ttcaacaatg acagcgacga gcccggacag cacttggtcg gtggtttcat ccaaggtttt 2142541 tactttttcg acctgggcgt taagcagcct gttttcgacg atgtcgacca gctcatcagg 2142601 gtcttctttc cgattgttaa tggcaacaag ctctctcatt aaatgaataa tataggctgt 2142661 atcgcataat ccatttagat agtaaagctg gatctcttta tctaaaatcg tgagcttgcg 2142721 aacacctaca tcatagctcg tccccatccc aacacggttt ttgaaatact cttcattttt 2142781 agctggattc cgataaaccc gaattttctc ttccttgtgg tccggcatga tacccgctcc 2142841 tttctaaaat aaactcgacc gctttcatgg tgattggcga cccttttgag atatcgtctt 2142901 ttctgcccat tttgccgata tccccgatac cgacaataag cgggagatca agtttatcaa 2142961 ggcaatagac tgtatctcca ctcattctgt ggtcatcaaa ttccctttcc ccgactttat 2143021 cgacgccgta ttcagttatt tctccattgc ggtcaatgct tacatcgacc ctggtccatt 2143081 cagcctgatg tgtttttgac gcgaccgcaa tcacaccgag cacttcaata gacggatggg 2143141 ttgcgacata ggttagagcg gcttctcccg ggccctctcc ttgaaggccg gagtcgtcaa 2143201 acatgacaaa tacaggatca tacggtgctg aggcgatcag cttgacaagc tcggcgccgc 2143261 tgcgggtgga aggattccct tttgattgtg aaatacatcg gcctcccact ttgcttgcgg 2143321 cgtattcaat tgttttagcg gcataaacat ccccgtctgt taccagtatg accttgcgtt 2143381 ttgtcgtcat gtcggcatta tcctttcggt ttgaaaataa cagctacgat aaaggcgaaa 2143441 agaatagcgg ctgagatacc ggccgaggtc agctcaaaaa tccccatgcc gattccgata 2143501 aatccgtgta tatgcgcctg atgcatggcg ccgtgcagaa gactgtgacc gaagctgacg 2143561 atcggaacgg tggcgcctcc tccggcaaat tcaataaatt tatcgtaaat gccgaaacca 2143621 tctaatattg caccgattac aacaaatgat gtcatgacat gagctggcgt caatttaaaa 2143681 atatccaaga gcagctggcc gacgatacag atggccccgc cgcagacaaa agccaaaagg 2143741 tagtccatat taagatgcac ctcctgcacg ctcaaataca accccgtggg cgatagtcgg 2143801 gatggtttct ttttgctgga tcatcgtcgg gcttaatagc gccccggtcg ccacgacaaa 2143861 tacacggttt agttttcctt ctctcagctg cttaaaaata tgagagtagg tgacaaccgc 2143921 tgaacaagca cagccgctcc ccccggcaaa gacctgctga tccggagtgt aaatcagaag 2143981 cccgcaatca tcatgctttg tgccgactgg atatccatct tcttttaaaa tgtcttttac 2144041 gattggagaa ccgacgcctg acaggtcacc tgtcaggatt agatcatagt catccgctgt 2144101 ccggttgaga tctttaaagt gctgcttaat cgtatcagct gcagccggag ccatagccga 2144161 tcccatatca aaaggatctg taattcctaa atcagaaacc ttcccgacag tcgcacttgt 2144221 gatttggata tcacccggtg tctgactgat gacaactgca ccgcttccgg ttacagtgga 2144281 ggtagcagtg tccggttttt ggcctccgta ttctgtcgga tagcgaaact gtctttccgc 2144341 agttgcattg tgactgctgg tggcagcgag tgcccttttg gcaaaccctc catcaactaa 2144401 ggctgatgcg acagccactg tttccattga tgttgaacag gcgccaaaca tacaaagaaa 2144461 tgggattttc aagtgtcttg ccacatagtt agccgtcacg ttttggttca gcaagtcgcc 2144521 tgccagcaat aggtcaatat catcttttgt cagattgttt ttttgaagtg caacattaac 2144581 agcgtcttcc atcagctgcc gttccgccat ttcccagctt ttttgattac aatgcatttc 2144641 gtcataggtt ttatcaaata aagagccaag cggtccgtct ttttcctttg gtcctgctgc 2144701 cgttcccgct gagttgacaa atatgggatg ttcaaatacc caggtttgct ttcctgttaa 2144761 tttcattttc ttctcctcct atgacatcag tttctcaaaa gcaaaccgaa tcattccaac 2144821 gatgtatgca gctacaactc cgaaaacaat aacatttcct gccagtttaa acatatttgt 2144881 cgctactcca agcactaatc cttcgctttt atattcaaga gccgcacttg ccatactgtt 2144941 ggcaaaaccc gtgacaggta cggctgaacc tgcgcctgcg aattgtccga ttctgtcata 2145001 gattccaaac cctgtaagca gggcagaaat taatatcagc gttgcagctg ttggattccc 2145061 cgcagttttt tcattgaaat caaaaaaatg gatataaaaa ttttgcagac cttgcccgat 2145121 tgcacaaatc agtccgccca ctaaaaaggc ttttacacag ttccagacgt aaggcggctt 2145181 aggctgatat gttttcactt ttgatttgta attttctttt atgtttgtca tcttgaaacc 2145241 tccttatgaa tggtcaataa agtacagcca gtgaaataaa gatcccgcga ttttcccaat 2145301 cacgatggcc attaacagaa taatgatttt acttctgagc ccgattcgtt tcgccaaaat 2145361 cggcaggaca tttaaaacct ctgtaagagc agccgctagc atcccgacga acaaacctgc 2145421 cagaagcccg accggcacag ctatccattt tgttagataa agatgattca tatgaagcgt 2145481 ctcccatccc ccgcaaaccg cgccaagaat aacagccgct tcataagcct gaacaaatct 2145541 cattgttttg gtgagctgca tcagccgcgg aatgattccc attacggtta aaaaagcaac 2145601 gaaacccgcc cccaccgtta tgcctccgcc gagcccgaca aaaatgatga acaatacact 2145661 aacgatcatg cagatccttt atggtttctt gattctcatg catggccaca tattgatcga 2145721 gatcaagctg atagttaaac atctcaacct ccagcgggct gggctcttca tttaggcgct 2145781 ttttaaatat gtggttaaaa aacacgatca tccccagtcc caaaccgatg ctgtatggga 2145841 tttgaagcaa atatggatag tcattcctct ctccggttat gatttcatat agtgcgatat 2145901 gaacatctct catgcttaca tcctcatgaa agttcatgat ggcaagacac gatccaataa 2145961 acagaagcag ccagacaccg ataaatagaa ccgttgataa atttcgcttt cgatactgaa 2146021 tttcaacaat ggtttctgct ccgcctacgg tttgaacatc aattgtcggg tcttgtaaat 2146081 gaatggctct gaggacttgt atgatatcca gaattacgat atttttatct ttttcgctca 2146141 cctgataaag cggcatagcc gaaagtttct ttttcagctg aagctgccct tctatttgcg 2146201 cggcatctcc aacggtaata atatcccctg gatgtgccag cactcggtgg cgaagccgga 2146261 taaatattcg tcgttccatc attgatcacc atctttcggt ggttatatat gtagtatgtg 2146321 gttcgatttt gttctcattc atccgctcga aaagaccata aattaccacg cttttgcaca 2146381 aaaaagctag cctgcactgc agactagcca tccgtatgat ccatttgaac cttgatctgt 2146441 tttaatattt tcttttcaag cctggaaacc tgcacctgag agatcccgag ccgctcagcc 2146501 acctcggact gtgtctggtc tttataatat ctgagataga cgattagttt ttccctttcc 2146561 tccaaatcgc tgatcgcttc tttcagcgca attttgtcaa accatttttc ttctgagttg 2146621 tcagcgattt gatcaagcag ggtaatcgga tctccgtcat tttcataaac ggtttcgtga 2146681 atcgaagatg gagcccttac cgcctcttgg gccagtacaa catcctcagc ttcaatctcc 2146741 aaatggtcag cgatctcctg caccgtcggc actctgccca gtgttttcga aagctcatcc 2146801 ttcgcgcgcc ggattttgtt tccaagctct tttaatgacc gtgatacctt tacggttccg 2146861 tcatcacgga taaatcgttg gatttctccg ataatcatcg gcactgcata cgttgaaaaa 2146921 cgcacatcat aggttaaatc aaatttgtca acagatttta acagcccgat gcagccgatc 2146981 tggaagagat cgtcaggctc atatcctctg tttaaaaacc gctgtacgac agaccaaaca 2147041 agacgcatgt ttttttctat gaggaggtct cttgcctgct ggtcgccatt ttggctttgt 2147101 ttgattaatt cctttacttc atgatccttc agctgagcgt ttttgccgtt tttcttaacc 2147161 tccacatcca taacaaatct ccttaattac aaagcgcttt gctttttgat aagtgctttg 2147221 ttaagcgaat cgttgttccc atttcaggcg atgaatcgat actgacatca tccatgaaat 2147281 tttccataat ggtaaagccc attccagagc gctcaagctc aggcttagtc gtaaatagag 2147341 gctgacgggc ttcttcaaga tctgtaatgc ctaagccttc atcacgaata gtcatatata 2147401 cgacatgatc ttccagcgtc actgaaatgt aaactttccc ttcacagttc tcttcatatc 2147461 catggataat cgcattcgtg acagcctctg acacgactgt tttgatttca gtcagttcat 2147521 ccattgtcgg gtccagctga gctataaatg aagcaactgt cacacgggcg aacgattcat 2147581 tctgactgag ggcagaaaac tcaaggtgca tttcattttt catgatgcca cccccagtgt 2147641 caggagtgcc tgctgttcag attgttcaaa tcggataatt ttaaacagac ccgacatatc 2147701 aaacaatcgc ttcaccgcag gagagatagc gcaaacaacc atttctccgc caatttgctt 2147761 aatttgcttg tatcttccta aaataacgcc aagccccgag ctgtccataa aggaaaggtc 2147821 ctccaagttc agcacgatat ggcgaatatc atccttctcc aatgattgag tcactttttg 2147881 cttcagggtt tcagccgtat ggtgatcgag ttcgcctgtt aatcgaatac aaagcacaga 2147941 ttctttgaca ttcatgtcaa ttccaaggct catgctcatt cctccttgat atgatcggat 2148001 aatgagtgtt tcgatttcga cggaatgaat tccttcaccg tgacaaaact agtggtcatt 2148061 cggcataatt acttaaattt tgtccagtct cccatcgtcc gctttaagaa tgtgataaac 2148121 ccggctttct tcatatcttc ttttgcagca acaggacttt cagcgagtac ttctccatcc 2148181 tttttcagaa caagagtgcc aagctcttgg cctttttgaa tcggagcact aatattgtcc 2148241 ttcatcttga tttctttttt cacatcgttc atatcctcgc cttttttcgt caatattgaa 2148301 atcggctcag atgtagtgag ttcgataaat ttttgtttcc cttttttgac ctttactttt 2148361 gctactgttt gatttcgttt atataaagga tgcgtttcat attggctaaa ggcgaagtca 2148421 agcatttttg tcacttgcgc gtttctttct ttaggcgtgc tcgctccgaa tacaaccgct 2148481 atggcccgca tgtttccttt tttagccgaa gcagtcagac aatatttcgc ttcgcctgta 2148541 tagcctgttt ttacgccgtc tacaccagga taaaatttga taaggcgatt tgtatttaca 2148601 agccaaaact ttttatctgt attttcacgc agataatctt catacgtgcc ggtaaacttc 2148661 gtaattgatt cgtatttcaa taattcctta gccatgattg ccatgtcata agcagagctg 2148721 tagtgtcctt cctcggtcag tcctgttggg tttttaaagg atgtattttt caatcccagc 2148781 tcttttgctt ttttattcat tttcttcaca aattcttctt cagagccgga aataaattca 2148841 gccatggcga cggaagcgtc atttcccgaa gcgattgcga tgcctttcag catttctttg 2148901 acagtcattt cttcgccggg ctcaaggaat atctgtgagc cgcccattga cgccgcatgc 2148961 tcgcttgtac ggaccttatc actcattttg attttgcctt tatctaaagc ttccataatc 2149021 aaaagcatcg tcataatttt cgtcatgctt gcaggcgcca gtctctcatt gctgttcttg 2149081 ttgtaaagca cttttcccgt gtcacgttct atcagcaccg cagacttcgc ttcatgagca 2149141 agctccgatg tacgttttcc gtcttgtttt gcaaatgcag acggtgcaaa tgtaagcagc 2149201 attataccaa tcaacaaagt ggataaaaga cgtttcatct caaaagccct ccatttcata 2149261 atccttttta ttttttccaa gcgtgatggt tttatacgcc actgatggaa aatgtttcga 2149321 attttgggca taaaaaaaga cagctgtgtg atatcagaca cagctgtctt ttggtcctgc 2149381 attgattcat atttattcgt actgagcgac gatcgcttta acaagcttta agaatccagc 2149441 ttttactttt tcggtcactt ccataacttc atcgtgactt aaaggctgat ccagaattcc 2149501 ggctgccgcg ttagagatgc aggaaatgcc aagaacccgc attcccgcat gattcgctac 2149561 aatgacttcc ggaacagtag acatgccgac tgcatcagag cccatcgttc ttaagaaacg 2149621 gacttctgcc ggtgtttcgt aagaaggtcc tgtcacagca gtgtacacgc ctttttgaat 2149681 tgggatatta aggtctttcg caatcttttc agccaggctg gacagatctt tgtcataggc 2149741 tgaagacata tctggaaatc tggcgccgaa atctgcttcg tttggcccga ttaacgggtt 2149801 tgttcccata aagttgatat gatcggtaat aatcattaaa tctcccgcac ggaattcagt 2149861 gttgacaccg cctgcggcat ttgtcacgat caacgcttcc acaccgagcg ctttcatcac 2149921 gcgtacaggg aatgtgactt tctccattga gtagccttca taaaaatgaa agcggccctg 2149981 cattgcaatg acggaaactc cttcaagagt gccaagcaca agctgtccgg catgcccttc 2150041 aacagtagat accgggaatt caggtatatc ttcatatttc agcttgaccg gattttcgat 2150101 ttcgtccgcc aaaatgccaa gacctgagcc taaaataagg ccgatctttg gagattccgg 2150161 caggttttgt ttaataaaag cggctgcgcg ttcaattctg tccttcaaga aacagtcccc 2150221 ctattgtaat aaagataaaa agcttttccc gtatttcggt ttatttgttt ggaaattatc 2150281 agcgatcgtt gcgccaatat cggcaaatgt atctgcaagc ggcagcattt gcgctttctt 2150341 atgttttttg ctgtaagcga gaatcggcac atactcgcgt gtatggtcag tcccatgatg 2150401 aatcggatca ttgccgtggt cggctgtaat aattaacaga tcgtcttctc tcattttttc 2150461 aaacacttcc ggaagccgcg catcaaattc ttcaagcgcg cgtccgtagc cttcagggtc 2150521 acggcggtgt ccgaataacg cgtcaaaatc aacaaggttc gcaaagctca gacccgtaaa 2150581 atcttctccc agcgtatcga tcaccttgtc cattccgtcc atattagaaa ccgttctgcg 2150641 tgaagaagta atgccttctc cgtcgtaaat atcagagatt ttaccgattg aaatcacatc 2150701 taagccgcag tctttcaatt cattcatgac agtgcggtca aacggcttca gcgcataatc 2150761 atggcggttt ggcgtccgtt tgaattgacc cggctctccg acgaacggcc gtgcaataat 2150821 gcggccaacc atatatttcg gatcaagcgt cagctctctc gccgtttcgc aaatgcgata 2150881 cagctcctca agcggcacaa cctcttcgtg agcggcaatt tgcagaacag agtcagcaga 2150941 cgtgtaaaca attaaagccc ctgtctccat gtgctcctgg ccaagctcat ccaaaatcgc 2151001 tgtgccggaa gccggcttgt ttccaataat tttgcggcca gatctctttt ccagctcttg 2151061 aagcaattca tcaggaaagc cttccgggaa cactttaaac ggtttatcaa tgtataaacc 2151121 cataatctcc caatggccgg tcatcgtatc tttgccgttt gacgcttctt gcatttttcc 2151181 ataataggca agcggatgtt ctgttttttc tacacctttg atatcttcga taagaccaag 2151241 gccgagcttt gccatattcg gcatatgtaa tccgttcata tgctcggcaa tatgaccgag 2151301 cgtatgagcg ccttcgtcat taaagtcagc ggcatccggc gcttcgccga ttccgactga 2151361 gtccatcaca attaaaaaca cacgattata tttgtatgca ggcatcttga aagcctcctt 2151421 tttttctata cgtctattgt atcgctaaga ggtctgacaa ctcaagtata aaccgttttc 2151481 attcccgttg acaatgtatt tggaaataat gagaaacttc aatattttct gtcgctctaa 2151541 acaaaaaagc cgcagccacc tgcggctatg ctcgcggatg aaactgcttg tacacatcct 2151601 tcagccttgt tttcgtcaca tgcgtataaa tttgcgtcgt ggatatatcc gcatgaccga 2151661 gcatttcctg caccgctctt aaatctgccc cgttctcaag cagatgcgtc gcaaaggaat 2151721 gcctgagtgt atgcggagtc agctctttct taatgccggc ttccaatgcg atttttttca 2151781 ggttcttcca aaatccctgg cggctgatct gtttgccgtg atgatttaaa aagagggcgt 2151841 cagatacatt attttttaac agttttcccc tggcttttgt catatattcc tcaatggcgg 2151901 aagcagcggc ttcaccgatt ggcacaatcc gttcttttct tcctttgccg aagcatcgga 2151961 taaaccccat agataaatga acatcagccg ttttcaattc aatcatttca ctgactcgta 2152021 tgcctgtcgc ataaagcagc tccagcattg ctttatcccg atatccgaaa gggctcgtca 2152081 gcttaggcgt gtccaataac cgctcgactt cattgagcgc gagcaccttc ggaagcgccc 2152141 gttccgtctt ttgtgtttcg atatgaacgg aagggtcctt atccgttact ttttccctga 2152201 gcagaaattg atgaaaagag cgaatggatg ccaaatgccg cgccgatgtc ttgccggatt 2152261 tccccgagtc cttcaaatgc tttaagtatt ggataatatg tatgcgggta acgtgattcc 2152321 aatctgtaac atgaagggtt tctgttaagt agagagaata gcttttcaag tcacgttcat 2152381 aggatacgat cgtattttga gagagccctc tctctaccat aacgtagtgg atgaaatcct 2152441 ttatttgatc tttcactctt gatctactcc ccgttttggt aaaaaaagat caaccggtcg 2152501 aaccatccgc ctttttcatc ctgatccatt tcaacaactt ttacagcgga gccttccggt 2152561 ttatcatacc gatgatagtt ttcatactct tgattcaccc atatcatagc ataatagaac 2152621 aaagcggtaa aaccggtaaa caggatgaaa actttcaatg catcgacagc tgttttcagg 2152681 aatcttccca tgtcctaatc gatcctttcc ctatggttcc agttatataa accatatgcc 2152741 aaatcagaaa ggttttatac atagaaacag caaaaaaccc tttccccatg agaaaaggtt 2152801 cgcgctcggc accgtctatt cagtttcttt tccgttacag cggtggcaaa tgccgtgaaa 2152861 cgtcaatcta tgatctttaa tcttaaattt ccaatcacgt tcaatgattt cttccacgtc 2152921 ttcaagcaaa tcttcttcaa tttcatcaac ggctccgcac tccatgcaca ccaagtggtg 2152981 atgaaagtga gctgcgccct ctttccgaag gtcgtaacgg gacacaccgt ctccaaagtt 2153041 aattttatct acgactttta attcagttaa taattcaagc gtacggtata ctgtagcgag 2153101 accgatctca ggagatttct cttttacgag gaggtataca tcttctgcgc ttaaatggtc 2153161 ttcttcgttt tcaagcagca ctcttactgt cgcttcacgc tgtggcgtaa gtttatagct 2153221 ggatgagtgc agttgtttct taatacgatc aatacggttt tccatgtctt tccctcctac 2153281 gccgcattcc atgactcatt ataacaaaat acgcgcagag ttccaactat aattattata 2153341 aactgataaa taaaatggtt ttcttttaat aatgatttta aaaaagtcta gatgtaagct 2153401 tttccattaa aacaggagat aagtatgctt caaagagaga tgaaatcagc gctaaaaaca 2153461 gaatgaccag cagcacaaag gcataccgcc cgaaccattg aatcggcgcg tcatgcaggc 2153521 ttcgtttcac gaacagctgt ctgattaact ttaaagaaaa cgcaattgca catgtgccca 2153581 taatgagata agccggaatc agcagcacat tttgcggcaa aacggagaca aatgatagga 2153641 aaaacccgct tactcccatc tgattgacta ggaacccgac agtaaagccg acgacgatcc 2153701 ctttcagaaa gatcataatg aaaataatcg gcatcccaat gacggaaatt cccagtatcc 2153761 acatcaggcc taaatacttt gcattatgaa agatactttg cccaaacata tcagctgaac 2153821 ttgcctgttt tccatccgaa agctgtccaa aaaattgact taagtagtag tataaatctt 2153881 ctttctggct gatggtcata ctgttgacaa taatcgcgcc aaagatgaca cccatgaaaa 2153941 acagcactga cacaaatata taaagagaga gatgatcttt gacatgcctg agaaacatgt 2154001 ccttataaga gatttttcgc ataccgtttc ctcccgcccg ctctagtgat ttgatttaat 2154061 agattgtatg aaagaaacag aaaaacatgc cctttttcaa aaagaaacaa tagagatgaa 2154121 tgctaggcgg ctttttgggg cacaaaaaaa tccttatcat caactgctgt atgatcataa 2154181 ggattcttat gcttccgttt attcaaaatc tcttttttgc tttttgtcat tcttccatgt 2154241 gtgctgaaag atggtgtgct gcctcttgat aataagacgt cacgtccgcc gtttctcaat 2154301 cgatgccccc gcttcttttt cgcttggctt tttgccatgt gatcactccc ttttttattt 2154361 tcatagtaat gataacaaaa ttgaacaatg ataagaaaaa aacagcacct gctacgacag 2154421 gtgctgttta gctacattta tttcactgct gtaagagctg catgctcgac agctgctgct 2154481 accgcatgat ggacttttga atcaagcggc tgagggacaa catcaccttg tttagtgcaa 2154541 gctgcgatgg cctctgctgc tgcgacaagc atatcatgat taatctccgt gctttttgcg 2154601 ttaagcgctc ctctaaaaat ccctggaaaa ccgagtacat tattaacaga acgcccgtca 2154661 gctgcatatg cggcgccagc ctgcagtgcg gcctccggct caatttccgg cttcggattc 2154721 gataaagcca gaatcacttg accagaacgt acaaatgccg gttttattaa acccggaacg 2154781 cccgttgtag caatgacaat atcacatgtt tccataagct cctcaatact ggaaactgcc 2154841 tgtccgccgt attgttcgag acggttcatt gctgactctg atttgtctgt tccgtataca 2154901 gcattcacac cataagccat gaacatccgg cagatggcca cgcctgctgc gccaaggccg 2154961 atttgcccca ctttcgcttc cttcaggtca acccccgcac tcctgcatgc cgaaatggca 2155021 gctgccagcg tcactacagc tgtaccatgc tggtcatcgt gcataacagg gatgttcagc 2155081 tcctctttta ggcgatcctc gatttcaaaa caatgcggcg aaccgatatc ctcaagaagg 2155141 atgccgctaa agcccggaga aatatgtttt actgttttga tgatttcttc aggatcactc 2155201 gtatcaagca gtatcggaat gccgctaata cccgccagct gatcaaataa agcagccttt 2155261 ccttccatga caggcatgcc agccacagag ccgatattcc caaggcctaa aattgcggtt 2155321 ccatccgtta caattgcaac agaattgctg atcgttgtat aaatagaagc tttttcaggt 2155381 tctttttcga tcagtcggca cacgtccgca acacctggtg tgtagacacg tcccagctct 2155441 gccagtgaac ggatcggcat tttgcttttc atttggattt ttccgccttc atgtgcggac 2155501 aggacttcat cagatacggt gtgaagcctg atcccttctc cgagggcctg tacagccgcg 2155561 atcacttcct gaagctgttc ttcattctcc acttgaacgg taatattccg cattgtgtaa 2155621 ttgggtccga cttttaccgt ctccacttca ccaatatccc cgcccagaag gccgatggcc 2155681 gtagccaccc ttccaagatt tccgggaacc gaaggcgttt cgatcatcag tgtccgaatc 2155741 atgtgtttcg ctatcattca gtgatcctcc cctattagcc tagtttttcg gctttaactg 2155801 tattgttttt cgtataccat ataaattttc ctgtataacc atagataatt gcaagaccta 2155861 ttgctacaaa actgagccac ataaacggca gataagagaa ggtagaaaca cctaaaatac 2155921 cagccatgta aatcccatta tcagaccaag gaaccatccc cgaagtcaat gttcccccga 2155981 cctctgagtt acgtgataac actcttctgt ccagatgtaa gcgatcatag ctgtcttcca 2156041 taattttcgg agtcaaaata agagatacat acatcgcaca gccgaagatg tttgctaaaa 2156101 acgctacgat cagtgtagac aatgtgacat tgccggctga agttaatttc ttttcaaacg 2156161 ttgaaacaat gacttttaac acgccgagtt tctcaagcag accgccaaaa ccaaggccaa 2156221 agatgatgac gacgagagaa tcaagcatac cgacaattcc accgcggttt aacaagccgt 2156281 tcaaaaattc aacatccgtt ttaatagaga agccgttgta cgcagttgca atcgcatggg 2156341 caatatccat tccttggaaa acaacagccc agattgcacc gagtaaagcg ccaattacga 2156401 taactggcat agatggcttt ttcatcgcca ataagactat gacgagaact gccgggatca 2156461 gcatccaaat atgaatgtca aacgtgtttt gcaaagatga ttttaagaat tcaactttat 2156521 caagatcaat atttttcccg ccgtacataa atccaacaac tgtaaagagt atagctgtaa 2156581 tgacataagc aggtattgat aaataaagca ttgctctcac gtgagccaat acatcgactt 2156641 ttgatagtga agaagctaga actgtactgt cagacagcgg agacagcttg tccccaaaat 2156701 aagcacctga aagaatagct cccgctacta gaggaagcgg aatgcctaac ccctctccaa 2156761 ttgcgatcat ggcaatgccg gcagttccga ctgttcccca tgacgttcct gttgccacag 2156821 acataatgga acaaataatt aacgttgcca gtaaaaagat acttgggtga ataaattcca 2156881 gtccgtaata aatcaaagtc ggcacaacgc ctccggcaat ccatgttccg atgagcgccc 2156941 caactgaaac gagaatcagt acggcttcaa ggccatttga tatcccatgt acaatcgcat 2157001 tttgtaaatc tttataagaa taaccgagtc taatacctaa aagcattgca ataaaccatg 2157061 aaacaaaaag cgccagctgt atcggcaagt cgagaaagac tgtaaacgat agaacaagtg 2157121 ctaaaaatac tcctagtaca ataataattt caaatagtgt tggcaatctt acatccttca 2157181 aaagaagtcc cccttcatgt aaaagctaaa acgctttcaa tatatagtgc aacacgtata 2157241 ctatacttcc tcatccctat gttgtaaaca gcttattcat ccgactattc ggagatgaat 2157301 aagctgtatt ttatacaaat tttatttttc taatagttct ttccctgcga tacctggttt 2157361 ggtcatctca tatgggttta aaataatatc caattcttct tcagtcagca catcatgctg 2157421 cagacaaaga tcccggacag attgccctgt cataattgct tccctggcaa ttctagctgc 2157481 cgcttcatac ccaagatgcg gattgacagc tgtgatcacg cctgcgcttt tttctacgta 2157541 ttgcttcata cgcttttcgt tggcttcaat gccttttaag cagttgtcag tgaacgaacg 2157601 gaagccgttg ttcatgatgc tgatggattg aagcaaatta aagacaagca cgggctccat 2157661 gacgttcaac tcaagctggc cggcttctga agcaaggcag attgtattgt catttccgat 2157721 aacctggaac gcaatttggt tgatcagctc cgccataacc ggattgactt tccccggcat 2157781 aatagatgaa cccggctgac gtgcaggcag agaaatttcc gcaagtccgg cgcgcggtcc 2157841 cgacgccatt aagcgcaggt cgtttgcgat cttcgacatg ttcatcatgc agacttttaa 2157901 tgaagctgat acctctgtat aggcatctgt attttgtgtc gcatcaacaa gatgatcagc 2157961 gccgacaaga ggaagcccgc taatatcagc aaggtgcttt actacctgtt tgatatattc 2158021 aggatcagcg ttcagccctg taccaacagc agttgcgccc atgttgactt catacaggtg 2158081 ctggcgcgat tgcttgattc gtttgatatc acgctcgaga acacggctgt aagcttcgaa 2158141 ttcctggcca agacggatcg gaaccgcatc ttgaaggtgt gtccggccca ttttaataac 2158201 agagtcaaac tcctgtgctt tttgcttaaa cacactatgc atatcttcca ttgttttcag 2158261 cagtttttct aagagcttca atgtggaaat atggatagca gtcgggaaca catcgttcgt 2158321 agactgtgac atgttcacat gtgtgtttgg acttaaatgg atataatctc cctttttatg 2158381 tcccatgatt tcaagcgccc ggtttccgat aacctcattc gcgttcatgt tcatagaagt 2158441 tccggcaccg ccctgaatcg gatcgacgat aaactgatcg tgccacttgc cttccagaat 2158501 ctcgtcagcg gcttgtacga tagcttggcc aattccttca tacagccgtt tcacgtccat 2158561 gttggcaaga gccgcagctt ttttcacaat cgccagtgcg ttaatcattt cctcatggat 2158621 tttgtatcct gtgatcggaa aattttcaga agcacggagc gtctgaattc cgtaataaac 2158681 atctgcttca atttgttttt ccccaaggaa gtctttttcc acgcgatatt ctttttggcc 2158741 gtttaacata atctttaacc ttctttctct ttgctggtta tcgtttttac attttacagg 2158801 acaacgtcat cagctatcgg cgtttccata attctcttga cgacaggaag atccgaagac 2158861 tgacctagcg cccacatcaa ttttggcaca attgcttctg tgttcatatt tcttgatcgg 2158921 ataattaagt cttggttgac tctgcggcca acctcgtaaa tgctcatgtc ttcgccttct 2158981 tcaagacatt gagtcgtaat gacgacgaca atgccgcttt cgatcagttc attcactttt 2159041 gacaaaatgt ctctgccttc aaacggcact cctccgctgc cataactctc aatgacaatt 2159101 cctttgtaca tgcttttcag ggcatcaaac atttcgggct ttaagcctgg atgcagcttc 2159161 agcagacata catctgtgca tagtgaagtg tcaactgtga aggtgtcgtt ctcaggttcc 2159221 gttacttgtt tgttgtattc gatcccgtct tcattgataa aagcgatata tgggtaattg 2159281 atgctttcaa atgcgtcgta gcttttcgtt cttaatttga tcgcacgcgt tccctgaatg 2159341 actctgccgt caaacacaac ataaacgccg cccacgcctt cacaggcaaa tcgaatggca 2159401 tctgtaatat tttttttggc atcggttttt tggaacgtga tcggaatctg cgagccggtg 2159461 atgacaatcg gctttttggc atgctgcagc atatacgata gtgcggcaga tgtataggcc 2159521 attgtatctg taccgtgagt aataacaaac ccgtcatagg catcataatt ttccttaacg 2159581 gcttctgcta tttccaccca gtattcaggc tgcatattgg tgctgtctat attcataagc 2159641 gactgagttt ccattgtgta atcgttatca agttttgata cgtaacttaa taattcatca 2159701 gccttgactc cgggagccag cccattttcc ccttcaactg aagcaatcgt tcccccagtt 2159761 gtcaacatca ataatttttt cataccatgc acctcttcac tgtatctaaa gatgggttgc 2159821 gagaaggtat tcgcttttcg catactttta atgcaattat agacacggaa aataaaatac 2159881 gcaagacatt attattcaat tcgcgtacac ttcctaatac ctatatgata taatcagctc 2159941 aaggtgaaaa aggagcggaa gttcatgaat ctagatcgtt taactgaatt gagaaaaaag 2160001 aaaaattggt cgcttcaata tacagctgac cttctcggta tcgcaaaaag cacatatgcc 2160061 ggctacgagt caggctaccg acggccttca cttgaagcgc ttgccatgct ggctgacctc 2160121 tttgacacaa cctgcgatga acttttaggc cgcgagaaac aaaagcagac tgctcctcag 2160181 gccatagaat tggccacgtg gagcagcctc gactttacca tttctgttga tggccagccg 2160241 ctgagtgaag atgaaatcat ccagctgatt acctttatac gcacaaaaag aaaagtacag 2160301 gaggaactga gttaatcttt agctcacggt ttaattttac cgtaggttcc tcctcctccg 2160361 gctttcaatt ccagttttcc ggatctcgct tttacgataa gcgccgcggt tttcggcggg 2160421 acaacgcgag ccaaatcttc ttctgcagcc tcatgaagaa cagccatttc tgttccgaag 2160481 gcttttttta gtttgtccag cgttttcggg cctacacccg gaacaaattg cagcgggatc 2160541 tgatgtacat atcgcggacg cgggacgcga acttcaagct gatcactcaa ttcacgcaat 2160601 ctatcgctga ctcccttggt aaatctggct tttccgcaat tcgcgcacgc tgtttccccg 2160661 cttacagcag gctctccgca cgcttcgcaa gccgtctgat aatatttccc caataacggg 2160721 tccaagccat aatttgcgat aattttcctg tcatcttgtc cctttaatgc aagagcaaat 2160781 tcagtaaaat cagctgactg cacatataat tcattatatt ctctgccgat tttccccaac 2160841 gaatgcgcat cagaatttgt taaaaaagga tacggattca attgcgatac gtgtgatgcc 2160901 atgtctgtat cacagcttaa tccaagctcc accgcgtcta tcatagatgg atcaaaaacc 2160961 tcagttaagc ttgatttaac cccttttcca tataagcttt tatgcggcgt aaagatatgg 2161021 gcggggataa acaggccgcc catatcctgc actttttttt gcaggtttaa gcccgtttca 2161081 taaatccgct gcgagcttaa atgaatattt ttcagccggg ctgacagcca gtttgaaaac 2161141 tgtttcatat cagccagcgt cggcataaat acgagcacat ggatcggtcc gctgcaggct 2161201 tcatcataaa tctccagctc gctccccaat aaaagagtcg tgctgcgata acggattcct 2161261 cccccgtcaa gctcgcgata ttttccagat gaaatgcctt cctcaagctc tagaatgact 2161321 tccggagaat gacagtcgat aatgccgagg agttcaattc ctttatgttc actggcttca 2161381 accaaaattc tgtccagcgt taatgttttg gcgcctgtta ttttgacagc ccttcctgta 2161441 aaggtccggc cgatatgaat gtgcaaatcc gcgtaaatct ttttcatttt tgtgcttgga 2161501 gcgcttcttt cagctgaaga tactgaatcg cgtaggctgt tttagcatca tatacttcac 2161561 gcgattcaac cagctttagc gcatcttcaa gcgtcacctc catcacttca acaaactcgt 2161621 cctcatcaag ctcccgtttt tcttcaagca cagaaagctc ctcagcaaga aaaacgtgaa 2161681 cgatttcatc tgcaaatccg ggtgatgtat aaaacgcagt tatttttgtc agtttttttg 2161741 ctgtataacc ggtttcctct tcaagttccc gaagtgccgt atactccggc tcctcacctt 2161801 tttcaagctt accggccgga atttcaacga tcgtccgctc aagcggctta cggaattgtt 2161861 tgaccatgat gattttccct tcatctgtga cggctagtac cgctacagct ccagggtgtt 2161921 tcacaatttc acgtttactg gctttgccgt ttggcagctc tacatcctcg acataaagat 2161981 caatgacttt acccgaaaaa atctgttctt tggcaattgt tttttcttct aatgatttca 2162041 tttcttcatc tcccgttctg tctctatatg atgccccata cattttatca tactagagca 2162101 aaagggggct tcttcgtgaa agtgcaccgc atgccaaaag gtgttgtctt agtcggaaaa 2162161 gcatgggaaa ttcgagcgaa gttaaaagag tatggacgca catttcaata tgtgaaagat 2162221 tggatctcaa agccataaaa gttgaaactt tagctccttt atattacggt caatacaaag 2162281 cctaaaaaag gagtgtgcac atgagaaagc gcaaattggg tacatctgat ttagacatta 2162341 gcgaagtcgg actcggctgt atgtctcttg gaactgaaaa aaacaaagca ttgtccattc 2162401 tggatgaagc gatcgagctt ggcatcaact atttggacac agcggatttg tatgaccggg 2162461 gacgcaatga agaaattgtc ggtgatgcga tccaaaacag acgccatgat attattctgg 2162521 caacaaaagc gggaaaccgt tgggatgacg gaagcgaggg ctggtattgg gacccttcaa 2162581 aagcttacat aaaagaggcg gtaaaaaaga gccttacacg tctgaaaaca gattatatcg 2162641 acctttatca gctccacggc ggcacgatag aggacaacat tgatgaaacg attgaagcgt 2162701 ttgaggaatt aaaacaagaa ggtgtcatcc gctactacgg catttcttcc atccgcccga 2162761 atgtgattaa agaatatgta aaaaaatcaa acatcgtcag cattatgatg caattcagcc 2162821 tgtttgacag acgccctgag gaatggctcc cgcttttaga ggaacatcaa atcagcgtag 2162881 tcgccagagg tcctgttgcc aaagggctct taactgaaaa accgcttgat caagcttcag 2162941 aaagtatgaa acaaaacggg tacttgtcct attcattcga ggaactgaca aatgcccgta 2163001 aggcaatgga ggaagtggct cccgatcttt ccatgacaga aaagtcgctg cagtatctgc 2163061 tagcacagcc ggctgtcgct tcagtgatta caggcgccag taagattgag cagttacggg 2163121 aaaatattca ggcagcaaat gcacggcgtt taaccgaaga ggaaatcaaa gcgctccaat 2163181 ctcatacgaa acaagacatt tacaaagctc atcgctcata gcagaaaaac cagcacctgt 2163241 acgggtgctg gtttatttat attgatgcca atccatttgg ctttcattta ggagttcttc 2163301 aaagctctta tttttttcga tctctttttt ctttctaatc tgttctgctt tttctctttt 2163361 ctgcctcttt tcatcctctt ccttcaattg gctcttcatc tccataagct ttgctttgat 2163421 atcggattga aggccgtctt ttagctggtg tttgtcaatg gatttttgtt ttttcatgca 2163481 gacttccccc atgttttgtt ttgaagccag tttatcacgg agcatataaa ctgaacaagc 2163541 agactctctt ctgatcactt tctcagcgta gcagtgttta ggtataatga tcttaaacac 2163601 gaattgccta tatatttcgt tgaaaggtgc tgtgactttt gaagaaaatc cttttggcca 2163661 ttggcgcgct cgtaacagct gtcatcgcaa tcggaattgt tttttcacat atgattctat 2163721 tcatcaagaa aaaaacggat gaagacatta tcaaaagaga gacagacaac ggacatgatg 2163781 tgtttgaatc atttgaacaa atggagaaaa ccgcttttgt gataccctcc gcttacgggt 2163841 acgacataaa aggataccat gtcgcaccgc atgacacacc aaataccatc atcatctgcc 2163901 acggggtgac gatgaatgta ctgaattctc ttaagtatat gcatttattt ctagatctcg 2163961 gctggaatgt gctcatttat gaccatcgcc ggcatggcca aagcggcgga aagacgacca 2164021 gctacgggtt ttacgaaaag gatgatctca ataaggttgt cagcttgctc aaaaacaaaa 2164081 caaatcatcg cggattgatc ggaattcatg gtgagtcgat gggggccgtg accgccctgc 2164141 tttatgctgg tgcacactgc agcgatggcg ctgattttta tattgccgat tgtccgttcg 2164201 catgttttga tgaacagctt gcctatcggc tgagagcgga atacaggctc ccgtcttggc 2164261 ccctgcttcc tatcgccgac ttctttttga agctgagggg aggctatcgc gcacgtgaag 2164321 tatctccgct tgctgtcatt gataaaattg aaaagccggt cctctttatt cacagtaagg 2164381 atgatgacta cattcctgtt tcttcaaccg agcggcttta tgaaaagaaa cgcggtccga 2164441 aagcgctgta cattgccgag aacggtgaac acgccatgtc atataccaaa aatcggcata 2164501 cgtaccgaaa aacagtgcag gagtttttag acaacatgaa tgattcaaca gaataaaaaa 2164561 gcgaaaggcc tcttcggctc tttcgctttt ttatgttaca gaacgtcggt aatgccatcc 2164621 atattttctc tgatccattc aatcgcaaga tctatcgttg taaactcctg cgtctcgaag 2164681 gtcatttcat cctgcaatag ccagacatct ttcttgatgg actctgctcc tccgattgac 2164741 cagtgaagca aggtataagg atggttttga ttcaggaagg atacccacgt tttattttgt 2164801 gctgtgttct tcattgcctt cagcttttgt tccacgtttc gcgtctccta ctttactaat 2164861 atgctcattc tggggctgag catttcagcc gggcttttca gcgccaatgt tttggctttt 2164921 tcattgtaat cgatcgtcat ttgatcgtca aaaaacactt tttgcgacga ttggatatac 2164981 agcggaatgc cgttcgtttc cagctgctcg cactgtcccg ttaattcttc tgccagccag 2165041 attgtcggga caccgcttac cgcgcagccg catccttctg catcgtaacg aagctgggct 2165101 ttttttcccg ggttggcgtc aaacgcctgc tgcagtgcct gttttgctgc atctgtcaca 2165161 tgtatgttca taaggtgaaa cccccgtttt catcattttc gctattgtag catacaatac 2165221 tgccattcgc attgtttctg ccttttttcc accgcttcgc attttcttct gcagtcttga 2165281 tccactcatc tttcccttgt atatactgat tgatgctgtc agggtgctgg gccgccagct 2165341 gttttttgag aacggcgtat tctttcgcta tgtttggatg agctctgaga taatctctga 2165401 ataacagatg cctttcaata gcagggtttc cctgttcgta catatggaca tgatgagtgc 2165461 gtttatttcc gcccttttgg aaataacgcc tgcccgctat accgttctca ccttttggtg 2165521 tatagccgtt ggccttcatt tgttcatcaa attggctcac ggcttcaatg cttctgactt 2165581 caattaacat atcaatgatt ggcttcgctg ccatgttagg tattgatgtg cttccgatgt 2165641 gatgaatagc gataatctcc ggcccgaaca caagtttcag ccgttctttt tcttcatcga 2165701 aacattctgc ccatttttcg ttgtagagaa tgatctcaac ttttcttttc ggatacaaat 2165761 gaaagaccga cagcaataga ccctgcgctg ctttgacggt ttctgccttt tggaatccgg 2165821 cctgtgtata gagtgacaca gccggggtat tgttctcggc tgtgactact tcgattttct 2165881 cagcgtcttc attatgatca atgacaaatt gcagaagcgc tcgtccaatt ccttttctga 2165941 aaccgtcagg atgcacaaca agcctgcaaa tggtgagata atgcatgttt ttctcatatg 2166001 aaatgacacc gatcagcttg ccgtttttcc gatatcccgc aaaccgttca tgggatgctt 2166061 gaatatcctt taccttctct tgtaaagcgg gaataccgtc aaaaccgata atctctgttt 2166121 cctttatgta ggcggggatc tgtacggcta aaatctcacg cgctatagtg gcttccttat 2166181 gctggagaaa ttcaatcatt cgtgttctcc tgaaacagcc gctgtctgtc gacttttgcg 2166241 acgcggactg catacgactc gtaccaaacg cttcttcctt tttcttttgc tgcttgatgt 2166301 tcagtgtgat gcctccaatg gttaattgcg tccatactgt cccaatagga aactgtgatg 2166361 ccccttccat ccgcttcacg tacgctttcc acgcctaaaa atccaggctg atccgccgca 2166421 agtgatacca tccgctccgc tgtttctcca tatcctgtgt cattttcgct tttgacagaa 2166481 gaaaaaatga ctgcatagta aggaggctca ggtgtttttg ataaaaaatc catcatattt 2166541 ccccctcata tgtttttgac aaatagtacc ctgtcttggc ccgggccatc atagtttgca 2166601 aacactgaga tgccatttac cgttttggtg cccttttcaa tatcaaaccc caattttgtg 2166661 tgatatgcga ttgatacctt attcacaggt gaagtgacac acttcacccg ggtgcagccc 2166721 ctttgtttta ctgtttcgat aaatacatca tacaattgtt tcccaatttg catttttctg 2166781 aaatccggat gcacaccgga aaaatgaatg tacgccgttt caggatcgga ttgcgattga 2166841 aatccgatta aaaatcccgt catgctgtta tgttcggatg taataaagct tgtgtcctga 2166901 aaatgctcaa aaaatagtct cggcaatttt tctttcagct gtctgccgcc ccaccattca 2166961 ttcagtacag acgttaccat ttcataatct gaagacgtga ttgttcgaat atccattacg 2167021 atttgatctc cctccgtctg gcaaaacgaa tgtcagctct ttttctcaca atataaaaat 2167081 tatattttgc ctggctggaa ttgtaaatgc cttctttcct gtatcatacg tttccagact 2167141 gccgagggaa caatgtttga tcattttacg cctatttctc ccccaaacag gaggagagac 2167201 tttacagcac aatatcaagc acttgatcaa gtttcagctt ataaagctga tcctcgtctc 2167261 cttttatcca tactgctttt tcaaactctt cataccggca gattttcccg gtgcagcaga 2167321 caatctcacc gtcctgaaag cagctgacag tgatatcctg agcaaactcc atcgcggcgc 2167381 aaagcgtttg attcatctct tccagcttat cggggtcaag gatcggcttt tgcagcttct 2167441 gtttaagtcg ctttctctcc agcaggcttt gcttatgttc cggcagaaac atcctgctcc 2167501 cttcccacag caggttgccc ctttttaaat ggtcgttcat ttataatgcc cccctatttt 2167561 agccgcacgt tcaaatgcct ggcctgccgc tgtcagtgac gccgccctga tgattgctgt 2167621 atcgccgaat cgatttttaa tgccatccat cacatagcct aggctcattt tctttgcata 2167681 atcctgaaat aaattgagct gccatatgtc atcagatgag agctgagaca gattgacacc 2167741 gaggcggcgg acgggtttcc cgtcccaaaa tgtaagaaac agccgtcgta cagcctcata 2167801 tacatcctgc gtagaattag tcggctctgc cagcttcact tgccggttga agcccgtcgg 2167861 ccaatcaaaa tcagcacccc ggcagctcac tgacactgtc tgccccatga ccccggcgtt 2167921 tcggcttcgc ctgcacacct cttcactcag ctcaagcaat acgaccttga tttctttgtc 2167981 aaagtgttcg tagtctctcg ggagagtcat tccatgacct atcgcctttt gcccgtccag 2168041 agacgaagtt gacacagggg aatagtcgat tccgtttgcc gtcatccaca gcacgtggcc 2168101 gttaatgccc catttctttt ttaaaagatc gagcggaaaa gccgcgagcc cgccgatcgt 2168161 gctgatgccc attcgattta aatgatgctt catgcggctc ccgacgccaa acatgctgcc 2168221 caccgggagc ggccacattt cggttttcat attttctttc gttaaggtaa aaataccgtt 2168281 cttattcttt ttggcaaaat tgtcacacgc aattttggcc agcgctttgt tagggccgat 2168341 tccgacccgt gcataaacgc cgatctcccg catgattctg ccctgaatgc ttttcgcgat 2168401 ctccatcggc gtcccaaaca gcttctggct gcctgtaatg tccatgaact gttcatcgat 2168461 ggaatacggc tccacaaggt ctgtatactc ctcgagaatg gccgtaattt gcagtgatac 2168521 atcaatatac cgctgcatac gcggccggag cacaacagcc tcaggacact tttcctgcgc 2168581 ctcccacagc cgtgaagcat tcaccacacc cttttgtttc gccagcgggc aggcagccaa 2168641 tacgactccg cccctttttt cagggtcacc cgaaacaatg acgggcctat ttttcaaatg 2168701 tggattttcc gctttctcta cagatgcata aaacgattgc atgtcaacga gaaaaatcac 2168761 tttttctttc atcatacaca cctctaaaaa gaacttatgt tcgcttttca ttatatgcga 2168821 aagtatgttc gttttatact ggtaaatgat tcttgtctga cagaaaatat gatccaaggg 2168881 tttgagagaa gaaaaacatt tagtagaata aaagcgaagc ataaggatag gagagtcatg 2168941 atggagaaat ttgtcgaaaa aatgctggga caggcattgc ggcaatacgg cagaaacgtt 2169001 gctatagatc cgttaagccc gtatgaaaaa caaagcctga aagcggctct acaagagaga 2169061 cggaatgaag aaccagatga ggatttgcat gcgcatatag aagatatcat ttatgactat 2169121 gtcacaaacc aaggcctgtt ctcttaaacg catgactgtc agttctttca gccgctgatg 2169181 cggcttccct ttgaaaacac cgcctgaaac aaataaacag tctcaggctt acagaaaaaa 2169241 agcaggattt tctcacgctc catagattca tatggcctgg cgtaaaattc ccctcaatgc 2169301 tcgcgcaaaa cggaataagc tgtccatgat cacgcgtata cactttttcg aagagatgtg 2169361 ctctcttgtt ctgtcatgcg gtccatgccg gttttcagcg tacatcttga tctcatagcc 2169421 ggtttcactg ccgatatgat ccacgttctg gcggcttaaa ctaacacacc ctcactgacc 2169481 aatcgctttg cttttcatcg gacatcccgt cattttcctt ctttcaagat gtaaactccg 2169541 tcagccacac gcatcctcaa cgcatagtat attgccatcc atacaatcag gcatactaca 2169601 tgtcaataac gaaatatttt gaacgatcta ttggagaagg aaattttttc atatatgata 2169661 gagaaagatc atacatacag gagagaatat aattcatgaa gaaatggaaa gatatccacc 2169721 cgatcagctg gacaattata atcggaacca ttttcggcag aatggcaaca tcgatgagca 2169781 ttcctttttt agcgatttat ttgacagccg tccaaggcgc atcagcttcc tatgcagggc 2169841 tggtcatcgc cgcgagctca tcagtcggca tcctcgcaag cttttacggc ggatatatct 2169901 cagataaatt cggcagaaaa aacatgatgc ttgtatcgat tttcggatgg atgctggtat 2169961 ttgcaggctt tgcggcagca tctaatctct gggtgttttt tgtagtaaac gcattaaacg 2170021 gtctttgcaa atcactgttt gagcccgctt caaaggcctt gttgtctgat atgacagaag 2170081 aaaaaacgag actgctagtt tttaatttac gctatgcggc tattaatatc ggcgttgtct 2170141 tcggacctgt gcttggccta tatttcggct catcgcaatc gactacgccc tttttggtgc 2170201 ctgcagtcat ttacggacta tacggaattg tgcttgccct ccaatttaaa aaacatccat 2170261 ccttatcagc accagcccag tcccgaaata tgagcgtgcg ggaagcgttt atggtcacgc 2170321 aaaaggatta tctttttacc attgctttgg tcggcattac gctatgcacc ttcggctact 2170381 cacaattcag ttccacattc cctcagtata tggcgcagaa ccccttgatc ggcaatggaa 2170441 cgaagctgta tgggctgatg ctgacattaa acgcaatcgt tgtgttggcg acgcaatttc 2170501 ccattgtcca ttttgcaaaa cggttttcgc cgctttgttc tctgatgctc ggtaatgtga 2170561 tggttagcat cagcatggcc attttcaccg tatcacacgg tgttccatca attgtgatga 2170621 ttgtcatcac atttacaatc ggcgaagtgc ttttattctc tatgatggat ttgtatgtag 2170681 accagattgc aaaaccagga ttaaaaggca cttatttcgg ggcaatcggt ttttcacagc 2170741 tcggaaacgt catcggccct tgggtcgggg ggatatgtat agacctgttt ggcgctggcc 2170801 ggccgattta tattttttct gtcctgagcg gcattaccct gctcggcctg ccatttttag 2170861 cgttcgccta tcggcaaatg aaaatggaga ccacaaaaca ccgttcccgt ctggaaaagc 2170921 cgctttaaat aaaaaacgga agagaatgaa tctctcccgc aaacatgagg tgaagaacat 2170981 gaatataggt gatgtgatgt ttcagctgtt tgtatttatt atatttgccg ctgtcgtctt 2171041 tgcggctgtt acaggcttca agtatgcgaa aaaccgaaaa gcgcagctgg atcgcattga 2171101 gaaaaagctg aacagcctgt ccgaagatca cgattaacag cttggggcaa cgagctctac 2171161 cttaatccgg tctggatcct cacaaaagac tgcataatgc ccgtctcctc cggcaaaagg 2171221 atgcctgtct cggtacaaca cacgatagcc ttttgccgtc aatttttcag tcatctgatc 2171281 gacttgaagc ttggattcag catgaaatgc gagatggttc agaccgactc ggcatctatg 2171341 gtattccggc tctagaaatg gctctttcgc ctgcacaatc actaggtaaa aacgatcttt 2171401 cttccagctg atgcctgagc tccatttttg atactcttta taaccaagtt cttttaagaa 2171461 ccagccccaa aaccgcctag acgcctccaa atcagagaca tacagttcaa tatgatgcac 2171521 atttcatacc ctccttacca acacttcctc gaccttatgc ccgtctccct tacgcaaaat 2171581 gagatctgac ctgaatttag ttggcaaaat attttcatat aaattcggcc ggttgacact 2171641 ctcccaaatc gaggctgcca tctcgtcagc ctcctgatcg gacaagtctt taaatttatg 2171701 aaaatatgaa tcaggatttt gaaaagctgt ttcccgaagc aggcgaaaac gctctaaata 2171761 ccaagtgaaa atccggcttt cctccgcatc cacataaatc gaaaaatcaa agaaatcgga 2171821 aacaaaaata cgcgggtttt cccggtcatc ctccaaggtg ggcgactgaa gaacattaat 2171881 gccttcaata atcacaatat ccgcctgttc tacaacctcg aacacacctt cctcgcggtc 2171941 ataggttaga tgggaataca ccggggcctt tacgctgtcc tttcctgatt ttaagtcatt 2172001 caaaaattcg agcagcgcct ttacatcata gctttcagga aatccttttc ttgacatcat 2172061 atttttcttt ttcagctcgg cagtaggaaa taaaaaacca tctgtcgtga taaggctcac 2172121 ttttggacgg tcaggcaaac gcgaaagcag cttctgcaag atccgcgccg tcgtgctttt 2172181 tccgactgcg acactgccgg caatgccgat aataaacgga attttggctg aatgtgggtg 2172241 cttcaaaaaa acattgacat gcttattgcg ttcagccgca gacttgacat gtaaatgaag 2172301 caagcgaaca agcggaatat agatcgtctc cacttcttca acagatagat aatcattcaa 2172361 tccttccaca gcttttgcct cttcttcaga tacagcaatc gacaaatgcc ccccaaaacc 2172421 agaccaagac tcccgattgt gctgtgtata taaagtatgt aggttaagtt ctttattttt 2172481 cactgtttac acctgactct ctgtaggtta aaacccttac aaagattgta acggaaaacc 2172541 ttttcactgt ctgcttattt ttcatttcgt ttttttagca aatcagcacc gattcggtta 2172601 tacgcagcca tttcatcttt tggaaccatg cttcctcccg ttccccagac gacatgtacg 2172661 gcatgttcca tcttatattt ctgagcatag cgccttccct cttctgtcga aaaaagctga 2172721 accggcccga acatgccagc aagagcagag ggctctaaat atttatcttc agatacagcc 2172781 agcatatgaa gcaaagtata aagcgtattg tcctctaccg tataacagcc gctcagaagc 2172841 ggttcaatca gcttgccgac aaatcctgac ggcctcccta cggcaagtcc gtcagcagcc 2172901 gtctgattat ccaggccgat atcctggacg gagatcttct cgtgaagtcc tgaataaagc 2172961 cctaacagca tacaaggtga atgagttggt tctgcgaaaa acacatgaac atcatctccg 2173021 tataaaagct tcagcccaaa tgctacaccg cccggtcctc cgccgactcc gcacggcaga 2173081 tacacaaaca agggcgtctc aagacttggc tttatattca tacagtcaag ctgtgttttt 2173141 aatcggcttg cagcaacagc atatcctaag aacagctgac gagaatgttc atcatcaata 2173201 aaataacaga atggatcttg ttccgcctgc cgtctccctt cgttcaccgc ttcactgtaa 2173261 tctgtttcgt actccataac agtgactccc ttttggcgga ggagatcctt tttccactgc 2173321 ttagcatcgg cggacatatg cactgtcacg cgaaacccga gtgccgcgcc gatgatgccg 2173381 atgcttaaac ctagatttcc tgtcgaaccg acagcaatcg aatagcggga gaaaaacccg 2173441 gtaaaccgct cttcctgtaa gatgcggtaa tcatcggttt cctgaagcat tccttcttga 2173501 agcgcgagat tttcagcata ctttaacact tcataaatcc cgcccctcgc tttaatcgat 2173561 cctgaaatcg gaagctcatg gtcgcacttt aaaagccatc ttccgggaaa tggctgctga 2173621 tatgccgctt ccagctttcc cttcatatgc tgcacctcaa aaagcggaga ctcgatgatt 2173681 cctttagcgc ctttcgtctc aggaaacacc tcggcaatgt aaggtgcaaa ccgctgcatt 2173741 cttttttccg cttccgctat ctcggttgcc cactcatctg cacggggtaa tggcccctct 2173801 ttcttgcctg aatttgccca gaatacaggc tctgcatcaa tcagtttctg aataaacgga 2173861 tctttaagca gagcatgaag gacttctgaa tgaactgaca ttcaacaatc tctcccttcc 2173921 actatcaaaa actgccccgt gagaaacaag ccactccacc acaggcagtt ctatcattat 2173981 tttttcatga gcgcgcgtcc tgccagcttt tctacaagag ctggaaacag ctgatacagc 2174041 ttagtgccgg cattcattaa acgcggaaga ttgatctccc gctttttcgt aaaaattgca 2174101 gctgtaattt gagctgccac gtcatcagga tcaagcatcc agcggccgac atttttggcg 2174161 tagtccccgc ctttatcagc aatggaaaaa aagtccgtct gaatcgggcc cgggttgact 2174221 gttgtcacat aaatgccggt tcccgaaagc tccatccgca aagcgtttga gtaacctaac 2174281 acggcatgtt tggtcgcgga atacaggcta gacttcggtg tggcgatttt ccccgcttga 2174341 gaggcgatat tgatgatatg tccctttttt tgctcaagca tttgcggaag caccgctttt 2174401 gtacaggcga tcaggccgaa gacattcaca tcaaacatcg ctttcatgtc atccaatgta 2174461 gagtctaaaa ccgtttcaaa tataccgaag cctgcattgt taatcagtac atcaatcgag 2174521 ccgatctgat cgcggacccg ggcgatatcc tctaggcggc cgacatccag aggaaaaatc 2174581 tcacactgtc cgctccattc ctcggttatt ttccttttga tttctatcaa acgatcctcg 2174641 cgtctagccg acagcaggac atgggctcct tcagccgcgc ataagtatgc gattctttct 2174701 ccaagccctc ctgaagcgcc ggttatccaa atcctttttc ccgctatatg tttcacccat 2174761 ttcacctctt cattgtttta aagtatacgg tatttccttc ccaatatgac gtgatggctt 2174821 cttcagcctc caacacatca aggtgacctg ccgtttctga catcgttaaa aacaattcct 2174881 tttcatatac agcaggaaaa agctgctgac agacctgaaa agcggtcatc ggcttttcat 2174941 ccagcatgcg acgcacatcc tccgtcctgt tcctctgctt gtcaaaacgc ttctcaatca 2175001 gcgcttgtac actggtgata ggctcgccgt gaccaggaaa tacgattgtt ggatcaagtt 2175061 gagacagcct tcgcaatgac cgctgataat ccactaaagg ctttgacctg acgtctcccg 2175121 ctttcggcgc ttccaaaatc ggattagacg agctgtttgc cagcagtaga tcgccgccaa 2175181 gcatccttcc gcttttttca tggaacagaa caatatgcga ttcagcatgt ccaggcatct 2175241 ccaacacaga ccagccctca agcccatcta tgcccatacc ttctctgatt gattttgtca 2175301 gagatctcgt acaggaaaat gcgtacgctg atcgaatcag cttttccgcc ttccccgtat 2175361 caaatggaac gcctaattca ggcagcagct tttgaaaaaa acgtttttgc caatccataa 2175421 aggcttgatt ttggctgata taaggttcgt tgaatgtatg cccaatcact tcgatttcat 2175481 ctgaaaagac atcaagcaag cctgcatgat cagcatgatg gtgagtcagt acaacctgct 2175541 cgatatctga caatttcaca tttacagcgg caagctgctc ttgtaaggct ctggcagcct 2175601 cttttgtatt cggcccggca tcgataagtg tcagcgcatc accttttacg aggtaaacga 2175661 taacatcgcc gacagcaaac ggtgtcggga cgcggatcgc aattacatct tcagttgtca 2175721 tcctttcgct ccttgtcttc attcattatt catattttag ctttttctcg gtcttgtgtc 2175781 attattgcag aatgagaaca aacctttttg aaaaagctat tgacattagc ttgtccgcca 2175841 ttgcataatg aacaacaaac taaaacgaga accattggaa cgctatgacg aggaatagta 2175901 tacaaggcaa tggcctaaga gagcgatacc cccggctgaa aggtgttgcg gcccgcttgt 2175961 ttgtagaacc tgccctcaag tcgcggttag gaaaacctaa acgtttcccg cgttacgggg 2176021 atttgagctg agcacaattt gtgctaatga gggtggtacc gcgaaccttt tcgtccttta 2176081 cgtgatgaaa aggttttttg ttgttctaat agaaggagga tatcaatgaa aaagatagga 2176141 tttgtcggcg ccgggtcaat ggcagaagca atgatcaacg gcattttgca aagcggcatc 2176201 acaaaaccag aacatatcta tattacaaat cgctcaaatg acgagcgtct gattgaatta 2176261 aaggaaacgt acagcgtgcg tccatgcaga gataaaaatg agtttttcac tcacaccgat 2176321 atcattatcc tcgctttcaa accgaaagac gcggcggaaa gcatcgacag catccggccg 2176381 tatatcaagg accagcttgt catttcagta cttgcaggcc ttaccatcga aaccattcag 2176441 cattattttg gcagaaagct cgcggtcatt cgcgtcatgc ctaatacatc agcggcaatc 2176501 agaaaatcag caaccggatt ttccgtaagc acggaagcaa gcaagaatga tattattgcc 2176561 gcaaaagctc tattggaaac aatcggtgat gcaacactgg ttgaggagcg gcatcttgac 2176621 gctgtcactg caatcgcagg cagcggcccg gcctatgtgt atcgttatat tgaggcgatg 2176681 gaaaaagcag cacaaaaagt aggattagat aaagaaacgg caaaagcact cattttgcag 2176741 acaatggcag gggcaacaga tatgctcctc caaagcggca aacagccgga aaagctgcgt 2176801 aaagaaatca ccagtcctgg gggcactaca gaggcaggtc ttcgcgcttt acaggactcc 2176861 cgctttgaag aagcaattat tcactgtatt gaagaaacag ctaaacggag cgcagaaatc 2176921 aaagaacagt ttgccggtgc cgccttagag agacattctt agatgtaagg acaaaaacag 2176981 aaggcacagt gccttctgtt ttttattttt cccgcagcag ctggccggca gattctgatt 2177041 gctttaatag cgcggagatc gtaaatgaaa gcaaatcggg aagcacttca aaggaataag 2177101 gcatatacaa tctttccgtc catttatgcg ggtctttacc agccggaccg acatttaaaa 2177161 ctgggacata taaagcctga tttttaccgc ttggcaatga ataccctctg ttaaagagcg 2177221 gcatattgct tgtgtatgca tcaacctcct gtttttccag ctgaagataa ctcaagtccg 2177281 aaagtccggg gaagtactga acctcccgta atgcaatgcc gtatcgctca gccgcataat 2177341 gctttatctg atctgctgta tttctgatca attgatcatc ctttgaagaa acagctggat 2177401 aaagcggcgg actataaaac agaacgatga gcggcgcatc ctccttacaa agcgaagcaa 2177461 gctcagaaac aattttcgtc gaaaaatccc tgtctccaag ctcccccctg ttagcaaagg 2177521 cataatttag agcccgctct gtttccgaga tccccgcacg cttttttgca cgcgagacca 2177581 gctcatcaaa tgtcaaaaca gtgacgtccc gctcaatcgg ctgaaatggc tcaaattgtt 2177641 gaaaatcctg tgttttcttc cgaacgttcg acatgatttc ctccgccgcc tgttctgctg 2177701 ttttaagcag catctgatgc agctcactag ctgagcgttt cattgacagc acattaaata 2177761 atgtgacggc tgtatgcggt gtctggactg aatatgcctc tttcaagtcc ttttgcatta 2177821 agtttaccgg cggcggagtg acctcgccat caaccttttc gcaataatca gcattcagtt 2177881 caagcaaacg gttaatctca gataccatta aatttgcgtt tagacctgaa aacggctctc 2177941 caacatgtgt ctcaatcccc ttgcagaaaa aacccgcaag caccttgcca atgcttcctg 2178001 tataaaaata ttgctgctga tcgccgggaa atttttcaaa catcggttcg gcattcaggc 2178061 aagcggttaa tgtgatatca tgctttttct ccatctcctt caatgcagga accgcttcaa 2178121 tcatgcctct tgaattcact tcctcgtccg gaaccgttat caacagcaga ttgccctcaa 2178181 aatgcccgtt cattgccctc tccagcatcg acagttgaat acaaagcccc gctttcatat 2178241 ccatcgtccc tcttccgaac agccagtctc cgctttcggc atctcttctc acacgttccg 2178301 ggagcagctc ttttttctct aaaaaggagc tcaaaagctc agcaggcttg caagccatat 2178361 gtttaaattc gccgtaatct tctatgtcaa cgacatcaaa atgactcagc agaagcactg 2178421 tctttttgac attcttcttt ttgactagag ccgtaagaaa agatctgcca tcgtccatcg 2178481 gatgaagtgt tacatcatca gggtgctttt gaaaataggg cttgtccttc aaaataaaat 2178541 aaagatactc tgcaagcgct acctcgccct ttgaaccggt gatgctttcg tattgcacaa 2178601 gagaagttaa aagtgccagc aattcgtcct tcgtctgcca attcattgat tccgcccctc 2178661 ctatgaataa aaatgcttct atactgaaaa ataaactgat ttctcgtcta ttatacagaa 2178721 atgtttgaca aaagcggttc atttgagcag tttatatgac gggaaagaaa tgacttgata 2178781 taatcaatct ctaaaaacct tacgggaggc gaaagaaatg gccagaaaat tatttacacc 2178841 tattacaatt aaagatatga cgttaaaaaa ccgcattgtc atgtcgccaa tgtgcatgta 2178901 ttcttctcat gaaaaggacg gaaaattaac accgttccac atggcacatt acatatcgcg 2178961 cgcaatcggc caggtcggac tgattattgt agaggcgtca gcggttaacc ctcaaggacg 2179021 aatcactgac caagacttag gcatttggag cgacgagcat attgaaggct ttgcaaaact 2179081 gactgagcag gtcaaagaac aaggttcaaa aatcggcatt cagcttgccc atgccggacg 2179141 taaagctgag cttgaaggag atatcttcgc tccatcggcg attgcgtttg acgaacaatc 2179201 agcaacacct gtagaaatgt cagcagaaaa agtaaaagaa acggtccagg agttcaagca 2179261 agcggctgcc cgcgcaaaag aagccggctt tgatgtgatt gaaattcatg cggcgcacgg 2179321 atatttaatt catgaatttt tgtctccgct ttccaaccat cgaacagatg aatatggcgg 2179381 ctcacctgaa aaccgctatc gtttcttgag agagatcatt gatgaagtca aacaagtatg 2179441 ggacggtcct ttatttgtcc gtgtatctgc ttctgactac actgataaag gcttagacat 2179501 tgccgatcac atcggttttg caaaatggat gaaggagcag ggtgttgact taattgactg 2179561 cagctcaggc gcccttgttc acgcagacat taacgtattc cctggctatc aggtcagctt 2179621 cgctgagaaa atccgtgaac aggcggacat ggctactggt gccgtcggca tgattacaga 2179681 cggttcaatg gctgaagaaa ttctgcaaaa cggacgtgcc gacctcatct ttatcggcag 2179741 agagcttttg cgggatccat tttttgcaag aactgctgcg aaacagctca atacagagat 2179801 tccggcccct gttcaatacg aaagaggctg gtaatgccca taagagatat cctgtagagg 2179861 atatctcttt ttttattttt agagaaacga tcggctaagg ttctccgtct ccctagtaga 2179921 accaattaga ggagatgact ccaatgaaat cagcttggat ggaaaagaca tatacaattg 2179981 acggatgtgc gtttcataca cagcaccgga aaggatcaag cggtgtaacg attgtctttg 2180041 aggccggcta tggtacttct tctgagacgt ggaaaccatt aatggcggac attgatgatg 2180101 aatttggcat tttcacatat gatcgggcag gcataggaaa aagcgggcaa agcagagcta 2180161 aacgaacagc tgatcaacaa gtgaaagaat tggagagttt gcttaaagca gctgatgtaa 2180221 aacctcctta tttggctgtt tcacactcat acggagctgt catcaccggt ttatgggcct 2180281 gcaaaaacaa gcatgatatt atcggcatgg tccttcttga cccagcttta ggcgattgcg 2180341 ccagctttac ctttataccc gaagaaatgc acaaatcaca tacgagaaag atgatgcttg 2180401 agggcacaca tgcagagttt tcaaaaagtc tgcaggagct caaaaagcgg caagtccact 2180461 taggaaacat gcctcttctt gtgttgtcat caggagaacg gactgagaaa ttcgctgctg 2180521 aacaggagtg gcaaaacttg cacagcagca tattgtctct atctaaccaa agcggctgga 2180581 ttcaagctaa aaacagctcc cacaacatcc atcatgatga acctcatatc gttcacttgg 2180641 ctatttatga cgtatggtgc gcagcgtgcc agcaggccgc tcctctttac caggcagtca 2180701 attaacgtaa aaaaagaccg ggccgtaagg gattcccggt cttttatatt attttgtttc 2180761 acggtgaagg gtatatttct ttaaacgcgg tgaatatttt ttcagctcca aacggtctgg 2180821 attggtgcgt ttattttttg ttgtgatgta atttcggtct cccgtttcag tgcaaagcta 2180881 aagtaacatt tactctcata attaacatct ccttataaaa cgtaatgatt acgttttatt 2180941 atacaacgtc atcacaaatt gtcaaataag agctccgcct tcagcctcgc gggacgttta 2181001 cctctaagaa atcatatgcc gccacgctat tggggaaaac gtcaaccgct tctttttgaa 2181061 gctccaaaga agcatctccc tgatatcttg cgctgatatg ggttaaaatg agctgcttcg 2181121 ctcttgcttc tttcgctgtt acagccgctt gttccgttgt actgtgataa taatcataag 2181181 caagtttacg gtcttcctta gcaaaggttg cttcatgaac aagcacatca caatccctcg 2181241 caagctcttt tagtttgtca cttactctcg tatcaccgga gaacacaaca gatcttccct 2181301 ttttaggagg ctccagaaaa tcattcccat tgatgattcg tccgtcttca agcgttaccg 2181361 tttcgccttt tttgattttc tgatatacag gtccgggcgg gatgttcatt tcttttaata 2181421 cgtcagcctt caaggaaccc ggtacgtctt tttcctgcac acggtacccg aaggcttcca 2181481 ctccatgaat aacagatacc gctgtgacaa taaactgatc gtcctcaaac acgattcctt 2181541 cttcaatttc ctggatcgca agcggatatg tcaaatgggt tttcgtgacg gcaaggcttg 2181601 tttcaataaa cgccttgatc cctttaggtc cgtacactgt cagctcgtcc tctccgcctt 2181661 gaaaggaacg gctccccaga agccccggaa gtccgtatac atgatcgccg tgcatgtgtg 2181721 taataaagat tttctctatt ttacgaggtt taatcgttgt atgtaaaatt tgatgctgtg 2181781 tggcttcccc gcagtcaaaa agccataccg aacgcctttc ttcaagcaat tttaatgcca 2181841 ccgacgttac atttctcgcc ttggcgggga tgccggctcc cgtccctaaa aaaagtaatt 2181901 ccacgtttcc ttcctcctac tagaaccaga tacctacaag aatacaggat caagcggaaa 2181961 atgtgaatct tgcctctgaa aagaacaatc ctttcgtgct agaaacattt tttcagcatt 2182021 ctgcttaaaa aagggcttaa atgtttgctt tcgttgaatt ttagatttaa aatgaaggaa 2182081 atatacgggg tgtactaaaa taaagcttcg aataaagtga ggtactttta gtgaaaacaa 2182141 accaacaacc aaaagcagta attgtcatat tcggtgcaac tggagattta gcaaaacgaa 2182201 aattgtatcc gtctattcac cgtttatatc aaaacggaca aatcggagaa gagtttgcag 2182261 tggtaggagt tggaagaaga ccttggtcta atgaggatct tcgccaaact gttaaaacat 2182321 ccatttcctc atctgcagat aagcatatag atgatttcac gtctcatttt tactatcacc 2182381 cgtttgacgt gacaaaccct ggttcttatc aagagctaaa cgtattgctt aaccagctgg 2182441 aagatacata tcaaattcct aacaacagaa tgttctactt ggcaatggct cctgaattct 2182501 tcggaacgat tgcaaaaaca ttaaaatcag agggtgtaac agctacaacc ggctggtccc 2182561 gccttgtcat cgaaaaaccg ttcggccatg atctgccaag cgcacaggca ttgaataaag 2182621 aaatccgcga agcatttacg gaagatcaaa tttacagaat cgaccattat ctaggcaaac 2182681 aaatggttca gaacattgaa gtgattcgat ttgccaatgc gattttcgaa ccgctttgga 2182741 caaaccgcta catttcaaac attcaaatca catctagcga atcactaggc gttgaagacc 2182801 gcgcaagata ttacgaaaaa tcaggcgccc ttcgcgacat ggtgcaaaac catattatgc 2182861 agatggttgc ccttcttgca atggagccgc ctatcaaatt gaacacagaa gaaatccgca 2182921 gcgagaaagt gaaggtgctg agagcactgc gtcctattgc aaaagacgaa gtggatgaat 2182981 actttgtgcg cggacaatat catgctggtg aaattgacgg tgtaccggtt cctgcttata 2183041 cagatgaaga taatgtcgct cctgactcca atacagaaac ctttgttgcc ggcaagctct 2183101 tgatcgacaa cttcagatgg gctggtgttc cattctacat cagaaccgga aaacgaatga 2183161 aagaaaagtc cacaaaaatt gtcgttcaat ttaaggacat tccgatgaac ctgtactacg 2183221 gtaatgaaaa caacatgaat ccgaacttgc ttgtcattca tattcagcct gacgaaggca 2183281 ttacgcttta cttaaatgct aaaaagcttg gcggagcagc acacgcacag ccaatcaaac 2183341 tcgattattg cagcaattgc aatgacgagt tgaacacccc tgaagcatat gaaaaactaa 2183401 ttcacgactg tcttcttggc gatgcaacaa actttgcaca ctgggatgaa gttgcccttt 2183461 cttggagctt tgtcgactct atttctgaaa catgggcagc aaacaaaacc ttatctccta 2183521 actacgaatc aggctcaatg ggaccgaaag aatctgatga tcttttggtg aaagacggct 2183581 tacactggtg gaacatataa taagaagaaa aaagccgaaa atgtttacaa gcattttcgg 2183641 cttttttacg ctgaacaaag gtataacaat ctccttaata acaaaacccc caaagcttaa 2183701 gagcttcggg ggtttctatt gattacttca tccattcagt atggaagatg ccttctttgt 2183761 cagtacgctc ataagtatga gcgccaaagt agtcgcgctg tgcttggatt aagtttgcag 2183821 gcagtacggc tgtgcggtag ctgtcatagt aggctaatgc gcttgagaat gatggcaccg 2183881 gcacaccttg ggcaactgca agtgaaatca cttggcgaag cgctccttga tagctttcta 2183941 caatattctt gaaatagctg tcaagaagca ggttgtcaag ctcaggctcg cgatcgtaag 2184001 cttctttgat cttctgaagg aatgccgcgc gaatgatgca accaccgcgg aagatcatag 2184061 cgatttcacc atatttcaga tcccagttgt attcttcaga agcagctttc atttgggcaa 2184121 atccttgcgc gtatgaacag attttactca tgaacaacgc ttttctgacc gcttcaatca 2184181 gctcttcttt attttctgta acaggcttca cttctggtcc tgaaagaagt ccgctcgctt 2184241 ttacacgctc ttccttcata gctgagataa agcgtgcgaa tacagattca gtaataatcg 2184301 gaagcggaac gcctaagtca agtgcgcttt ggcttgtcca ttttcctgtt cctttttggc 2184361 ctgctttatc aagaatcaca tcaacaagcg gtttgcctgt ttcttcgtct ttttttgtga 2184421 agatgtcagc cgtaatctca atcaggtagc tatcaagctc acctttattc cattcagcga 2184481 aaacttcatg aagctcatca gcagaaaggc ccagcacctg tttcagaatg aaatatgatt 2184541 cagagatcag ctgcatatct ccgtattcaa ttccgttgtg caccattttt acgtaatggc 2184601 cggcgccgtc cggaccgata tatgtcgtac aaggttctcc gtcaactttt gcagaaatgg 2184661 cttcaagaat cggttttaca agctcatgtg cttctttttg tccgccaggc atgatagaag 2184721 gtcctttaag cgctccttct tctccgccgg aaacgcctgt tccgataaaa tgaatgccgc 2184781 tttcagcgag ttctttgtta cggcgctgtg tatctttata gtatgtatta ccgccgtcaa 2184841 ttaaaatatc atccttctct agatgaggaa gaagagattg aattgtcgca tctgttgcag 2184901 ttcccgcttt aaccattaat aagattttgc gcggtgtttc caaggattgg acaaattctt 2184961 caatgctgta agtgccaaca acattttttc cttttgcctc ctgtaaaaac tcctcagttt 2185021 tactgcttga tctgttgtaa acagaaacag aaaatccccg gctttcgata tttaaagcca 2185081 gatttttacc catgaccgca agtccgataa cgccgatttg ttgttttgac atattctaac 2185141 gtcccttctg caaacgttta atcattttaa aatttaaatt aaaataaaat gatatttata 2185201 ataaagaaat taccatacat tcaccctttt tttcaagcga ttcagctttt cttttcatct 2185261 tgaaaaaaat ctttattaaa gcttgttccc tttgttttgc tctcctcttt ttttaacgtt 2185321 gccccttttc tgatcagttt ggtaccgtac tttttattca gcttttccat catctgctga 2185381 atgggctcat ccttcgcatc ttcattaaag ctgaacaaat cgagctgttt ataggcctgc 2185441 tctttttcta ctaaatccgt tccggtaatg ccaagcagcc tgacaggatt tttattccaa 2185501 tgtttaaaaa agaggtgctc cgcttctttc aaaatgtcat ttttttgatc aatcgggttt 2185561 ctcagcgtag tgcttcttgt gatggttctc caatccgcat atctaatcat aataaaaagc 2185621 ttcgaagcca tgacttcctt gcgctgtaaa cggtcactca cagaagcggc aagctttcta 2185681 aaaacgccta acagctcttc ttcatcactg gaatcatggg aaagtgtcga tgagttgccg 2185741 acgcttttaa attcgtaaat gcgctccggg tcaaccggcg catggtgaat gccatttgct 2185801 ttatttttaa ggcgcggacc gttgatgcca agcaggcgct tcagcgagtg ttcatcagct 2185861 gcagctagct ctccgattgt atggatgccg agtcccttca gtttttccgc tgtctttttg 2185921 ccgactccgt gcatctctcc aacaggaagc ggccacagga tatcgggcac ttgcctcttt 2185981 cttaagatcg taattccaag cggttttttc atatcagacg ccatcttagc gagaaattta 2186041 ttcggtgcaa tccctatgct tgacgggagc agcagctctt tttgcagcct gctttggatt 2186101 tcttttgccg tctctagagc gcggctgctg tatggtgtat cggtcatgtc catatagcct 2186161 tcgtcgatgg agacaggctc cactaggtca gtatattcac gaagaatggt aaacatcgct 2186221 cgtgaagagt ttctatagcg gtcaaagttc ggcggaagaa cgatgagctc aggacaatgg 2186281 cgcttcgctt gccaaaccgg catcgttgtt ttgacgccgc gcgctcttgc ttcgtagctg 2186341 catgttacca caatgccctt tcgctccttt acgtttccgg caactgcgac cggctttccc 2186401 cggagagccg gatcatatgc catttcaacc gacgcataaa agctattcat atcaatatgg 2186461 aaaataattc ggctctttcc cggcataaac aaatctcctt ttcggtcatt agacaacagc 2186521 ttgtacatat agtaaaatga agctattgaa tggatgtgat gacaatgttt gtggaatcga 2186581 taaatgacgt tttattctta gtcgattttt tcacaattat tcttcctgct ctaacggcaa 2186641 tcgggattgc attcctctta cgggagtgcc gtgcgggcga gcaatggaaa tcaaaacgaa 2186701 cagatgaaca tcagacggtc tttcacatta accgaacaga ctttcttatt attatatatc 2186761 atcgcattac aacttggata cgtaaagtct tccgcatgaa ttcgcctgtg aacgatgagg 2186821 aagacgccgg ttctcttctt ttataaaccg catttataaa aaggaggaga acaaaattgt 2186881 taaaaacata tcaaaaactt ttggctatgg gtatcttttt gatcgtatta tgctcgggca 2186941 atgctgcatt tgcagcgact aatcaggtgg gaggcctcag caacgtaggt tttttccacg 2187001 attatttaat cgaaccgttt tccgctctgc ttaagggtgt tgccgggctg tttcacggag 2187061 aatacggact ctctattatc ctcgtaacca ttattgtgcg tatagttgta ttgcctttgt 2187121 ttgtcaatca gttcaaaaaa cagcgcatct tccaagagaa aatggccgtt attaaacctc 2187181 aggttgacag tatccaggtt aagttgaaaa agacgaagga cccggaaaag caaaaagagc 2187241 tgcaaatgga aatgatgaag ctgtatcagg agcataatat caacccgctt gcgatgggct 2187301 gtcttccaat gctgattcag tctccgatta tgattgggct ttattacgcg attcgctcaa 2187361 cacctgaaat tgcgtcacac tcgtttctat ggttcagttt agggcaatct gatattctca 2187421 tgtcccttag tgcagggatt atgtattttg tccaagccta tatcgctcaa aaactgagcg 2187481 cgaaatattc cgctgtcccg caaaaccctg cagcgcagca atccgcaaaa ttgatggtgt 2187541 tcatcttccc tgtgatgatg acgattttct cgcttaatgt gccggcagcc cttccgctgt 2187601 actggtttac aagcggactg tttttgacag tgcaaaacat cgtccttcag atgacgcatc 2187661 ataaaagtaa aaaaacagcc gctcttactg agtcggtgaa ataaaaaagc aaccccgtgc 2187721 aaaaagccgg ggttgttttt tgttacttgc aaagtaccgc gccaaacagt cttgtttatc 2187781 atggctgaag cagaaatggc catcctaaaa aatagccgta tcgtttaaaa agaaggaaat 2187841 cgggaatacc tttactcacc tccaaccgaa aggagcctat acgttgacgg aacgctttca 2187901 gcaaaaaaat atttctgtac ctgatggaat ctggatcatg agacaaacct ggaatgatgt 2187961 cttatttgct cactggcctg ttgatgtttc tatccttcgc gctttggtac cgtccgtttt 2188021 agaattagat acatataacg ggcaagcttg gatcagcatg cttcccttta tgctcacgaa 2188081 cctgagggcg cgttatctcc ctgtcattcc cggtgcgcgt gcatttcctg agcttaacct 2188141 ccgcacctat gtcacgtata aaggcaagcc cggcatttat ttttttagct tagatgccga 2188201 tcatcgtctg gcggtccttg gcgctcgcac attctttcat ctgccttatt tttacgcgga 2188261 tatgaagtcc gaaaaaaacg gtgatgccat tgactatgtc agcaagcgga aaaatgacaa 2188321 agaagcagca ttccacgccg cataccggcc aatttcagcg ccttttacag cagaaaagga 2188381 ttcgctcgat tactggctga cagaacgata caggctctac accacttatc gcaataagct 2188441 ctattacgaa gacatccatc atcatccgtg gctgctgcaa aacgccgaag cagaaatttc 2188501 agtcaatacg gtgactgatg ctcacggtat tacattgccg gagtcagacc ccttgcttca 2188561 ttatgctaaa aaacaggatg tgttattttg gccgcttagg aaatggagct aaaaaaaccc 2188621 gatgcgggaa atcgcactcg ggttttcttt ttttattttg ccgcctcttc aataatggca 2188681 acaaccattt ctgccgtttt aacgagctct tcgatcggca ttttttcatt ttttgtatgg 2188741 atttgctcat aaccgacagc aagattgacc gtcgggatgc catgaccagc gattacgttc 2188801 gcgtcgcttc cgccgccgct cgtttgcagc tcgcttggac gtccgatttt agcagccgct 2188861 tttttcgcga tttcaacaac ttggtcgccg tcttgatatt taaagcccgg atacataacc 2188921 tcaatttcga cttctgcgcg tccgcccata tcagcagctg cctcttcaaa agcagctttc 2188981 attttttgaa cctgagcttc cattttctca ggaactaaag agcgcgcttc agcaagaata 2189041 tgaacttcgt cgcacacaat gtttgtttgt gtgccgcctt caaaccggcc gatattagct 2189101 gttgtttctt catcgatacg gcccaatggc atttttgaga tggctttgct agcgattgta 2189161 atcgctgaaa tgcctttttc aggttcaacc ccggcgtgag cggttttccc gaaaattgcc 2189221 gctcttacct tcgcctgtgt cggcgcggcc acaatgatat ttccgacttt tccgtctgaa 2189281 tcaagagcat agccgtagga tgcagtgatc atagaacggt caagcgcctt cgctccgatc 2189341 agacccgatt cttcccctac tgtgatgatg aattcaatcg tgccgtgttc aatattttct 2189401 tctttcagca ccttaatcgc ctcaaacatt gcagccaatc ccgctttatc atcagcacct 2189461 aaaatcgtcg tgccgtcagt tttgacgtaa ccgttctcta caactggttt tacgccgttt 2189521 ccgggtacaa ctgtgtccat atgagatgta aaatagatcg tatctgtttg ttttgtccct 2189581 tttagcgtgc aaatcaggtt accggctccg tggcccgtga tatccattgt atcgtcttct 2189641 ttaacgtcca cacctaaatc agaaaatttt cgtttcagca ctttgcagat ttcagcttcg 2189701 tgctttgttt ctgagtcaat ttggacaagc tctaaaaatt cttccagcag gcgtttttca 2189761 ttcaccattt gtaagtccct ccatattaaa gcggtatgtt accgtgcttt tttttcggtc 2189821 tctcttctgt cttatgtgta agcatatgaa aagcttgaat cagtcttccc cttgattctt 2189881 ccggcaaaat gatgtcatcg accattccac aagcggccgc tttgtatggg ccggcgtttt 2189941 gctttttgta ttcagcagtt ttttcgcgtt tcgtcttttg cgggtcagct gaagctttga 2190001 tttccttttc atacaaaatc gatgccgcac cttctggacc catcactgcg atttcagcat 2190061 tcggccatgc aaacacaagg tccgctccga tcgctttgct gttcatggcc acataggcgc 2190121 cgccgtacgc ttttctaatg atgagtgtga cttttgggac agtcgcttca gcataagcaa 2190181 acaataattt tgctccatgc ctgatgattc cgttgtgctc ttgctgaata cccggcagaa 2190241 accccgggac atcttcgaca gtcaacagcg ggatatcaaa tgcgtcacaa aaacggatga 2190301 accttgctgc tttatcagca gcgtcaatcg tcaggcttcc cgccagatgc ttcggctggc 2190361 tcgccacgat gccgattgct ttttcaccca gccttgcaaa cccaatgaca atgttcttcg 2190421 caaaaaatgg ctgaatctca aaaaaagact gcgggtcagc cagctcccta atcaccttcc 2190481 gaacatcata aggctttgtc gtatcagcag ggacaagacg gtttaataac ggtctggacg 2190541 cctctttctc tggcttcggc tctgttgtcc ggccattcag cggcaaataa gacagtagtt 2190601 ttctcacccc tgtcagaacc tccttctccg tatgcccgga aaagtgggcg tttccgctga 2190661 cggcattatg tatccccgct ccgcctaagc tctccgcatc aacctgttcc cctgtcactt 2190721 tttcaatcac cttcgggccg gtaataaaca tccggccagt ctgttcagcc ataaatataa 2190781 aatctgtgag tgccggagaa tatacagcgc ctccagcgca cggccctaaa ataaccgata 2190841 tttgcggaat gactccggaa tataagacgt ttcggtaaaa tatgtgaccg tatccatcta 2190901 atgataacac accctcttga attctcgcac cacctgagtc attcagcccg ataatcggcg 2190961 ccttattttt tgctgccaga tccatcaaag cgcagatttt cctggcatgg gtttcgccaa 2191021 gcgcccctcc gtacactgtg aagtcttgcg caaatacata aactgagcga ccgtcaattg 2191081 tgccgtaccc tgtcacgacc ccatccccta acatgcgctg ttctcttgtt aacacttgac 2191141 tttccatgaa ggggtgtaat tcgataaagc tgtcctgatc tagaagaaat atgatccttt 2191201 cccgagcagt gagcttgccc ttttgccgct gctgagccag cttttcccgt cctccgcctt 2191261 cttctgcctg cttgcgtttc gtgtaaaaat gatccatgtg ctcattcatg ctcattgtgt 2191321 tggtctcctt tcggttcaca aagctctaca agaacaccgt ttgtttcccg aggggaaata 2191381 aacgcgatct ttttcccgtt cgctccctgt cttggaaacc tgtcaatcaa ttgaacatgc 2191441 tgatcagaca atgcttgaag ctgttcagat aggcagttgc acaaaaacgc aatatgatgc 2191501 agtccctgcc ctttcttctc caaaaataaa tggacggggc tgtcagctgt caacggctct 2191561 atcagctcaa gtttgacgct accagcttga aaaaaagcaa cattcacctt ttgctcttca 2191621 accgtttctt gatgaagaaa tgcaagcccc aatacatttt cataaaagct tcttgcatct 2191681 tttatcgaaa aaacggctat cccgatatgg tcaagcctgt tcattttcat ccctgctttc 2191741 gctaatagat atcgcttgtc cgcccattca aaacacgcta aaatatagac agattgttta 2191801 aggagtgaaa atcatgtctc aaaaactgat gaaaagcgtt ttgatcgtga ttttgggagt 2191861 ttttattctt tcaactgtac tctcaggaat cgtcatgttt ctataacgat aaaaaagcag 2191921 gcgccttatt caatgggaat atcctgcttt tttatcagag ctttatgctc gatggcaatc 2191981 tcctcaaaag agcggttgtc gtccgtgatc agcactctcg ttcctactgg tatcgtttga 2192041 aacaaatgaa caacctcatc gttatgcata cgtatacagc cgttagacac aaattttcct 2192101 actgattcct ctcggtttgt cccatgaatt ccataaatcc gcccgtccgt tcctttcgcg 2192161 tcaaatccga tccatcttgc cccaagcggg ttatcaggag atcccccttc aatatttttc 2192221 tttctgtagt aaggattttc cgcttttacc gttaccgaaa actctccttc aggcgtcaaa 2192281 tcatctgttt ttccagtcgc cacactatac acgccttcta ctttgttgtc gaggataaca 2192341 gcaagttcat ttgttcgctt gttgacaata acatacggat cacccggcag cggattttcg 2192401 ccgagcggcc aaatcggtga aatcatcatg aaaatcgaac ataagaaaaa acgcataagc 2192461 tcctcctttt tcattaggtt gaccaatgaa ggaagagctc atgcgaatca tccgagtgat 2192521 ttttgcgctt ttattccttt aaaataactt ttaatcacta aatattgttc catttcgccg 2192581 agaagatgga agagagcggc cctcgcttca aattcctctc tagtcgcagg aagcggcatc 2192641 tcctcaaatt cttttctcat gtcagcaagt cttttcagaa atttgtatgc tgtattccca 2192701 gggtgtatcg cctcccgcaa atcatgaata aattcagcga tcatttttcc ctgatctacc 2192761 gtgatggaga tcgatgtcac tttagggaga aggcgttcga taatttcaaa ttgcttttct 2192821 ctcattttaa aataatgata atgcagattt tcataacgca aaatgtggtt ttgcacatct 2192881 cgatatgcca ggtttttagc ctccgtaatg agctggtgcg tttccggaat ttcttttcct 2192941 gaccaatctt gctcaccagt taacaaatac cgttcgattt ctgcaaaaat gacagcaaag 2193001 ttatcctcta tctttttgcg gtaggcaatc agtttccggt caagactagg catatacaag 2193061 ttcatcaata gagcgacgcc gatgccaacc gtaatcagct gaacttcatt ccagatgaaa 2193121 gtaggcgtaa tgccgccgga catgtataaa tgaaggataa taacagaact ggtgacgata 2193181 ccctcgttaa tttttaacag aaccgttatc ggaatgaata tcaaaagaag cgctccgatc 2193241 acaaacgggt ggtagccaat aagctcgaaa aagagataag aaaaagcaat tgccagacag 2193301 catgccgaaa agcgggccca tgaggcctga agcgaccgtt tttgtgtgat ttgtatgcac 2193361 aaaatggtga tgattcctgc tgatgcgaag ttttgcaaat gcaataactg gcttatataa 2193421 atagccaaag ctgttccaag cgcggtcttt attgtgcggt aaccaatttt aaacatgtcg 2193481 gactccattt ctatttgttt cttcaataaa aaagaagagg cggccagcct tcttcttttt 2193541 tatattctat aatattttct ctaaaaagtc ctgcgctctt ttggattttg gcgacataaa 2193601 aaattccttc ggattgccgt cttcgacaat cattccttgg tccataaaca gcacacggtc 2193661 tgccacttct tttgcgaagc ccatttcatg tgtgacaatc accatggtca tgccggtttc 2193721 gaccagctct ttcatcacct gtagcacttc tttgaccatc tctggatcaa gggcggaggt 2193781 cggctcgtca aacagcatga tgtccggatt catcgcaaga gccctggcaa tcgcgacacg 2193841 ctgtttttgt ccgccagaca aacggtttgg atagtcattt cgcttttcaa acaaaccgac 2193901 tttgcggagc aggtcctcag ctttctcctg tgcagcctgt tttgattctt tttttacatt 2193961 gacaggcgcg tacatgatgt tttcgagaac cgttttgtgc ggaaagagat gaaaatgctg 2194021 aaaaaccatc ccgatgtttt cccggacctt taatgtgttg gttttcggct tcgtaatctc 2194081 tgtgtctttt attgtaatgg ttccgccgtt aggcttttcc aacaggttta aacagcgtaa 2194141 gaacgttgat ttgcctgagc ctgaaggacc gatcacggca acaacctcac cctcagcgat 2194201 tgttgttgaa atgtttttta atacttcgtg tttcccaaat gattttgaca gcttttcaac 2194261 cttaatcatt ggatttcagc ttcctttcta cagccttgcc gataaacgtt aaaatcagga 2194321 caagcacata ataaatcaat cccgcgataa tgagcggctc aaggtaattg taagtggcgg 2194381 cgccagcttg atatgcgcgt ctcatgacat caccaagccc gatgacggtg acgatcgccg 2194441 attcttttgt taacgtaatt aattcattca caattgcagg tgatatattt ttgaaggcct 2194501 gcggcagcag cagatccttc atcatttttc catacgggac accgagtgca acagcagctt 2194561 ctttttgccc tttatcaatg gcattgattc cggctctgat aatttccgat acataagcgg 2194621 cggaattcaa agacaatgcg acaaccgcag cccaaaactg gtcaatttga aatccgagca 2194681 gctgaggaag gccaaaatag acaatcataa gctgcagcac taaaggcgtg cctcggaaca 2194741 ctgatgtata aaaatcagcg atccagataa acgggcggaa tgtgctgatc ttgcataagc 2194801 ttagcacaat accgagtata agtccgataa tagcagatac aacaacaatt tttaatgtaa 2194861 ttgccaagcc ttctaatata aaaggaattt gggggatcgt tgctgaaaaa tccaaattca 2194921 tagcctttgt ctccttttct tacaggaaaa aagtttccta ttcaataaaa aggctcaacg 2194981 aaaaagttga gccgcttttt tttacttctc gccagtgaac cattttttct tcaatttctc 2195041 aagctctccg ttatcttcca tttccttgag cgctttattg aatttgtctg tcagttcact 2195101 gtcctttctg aaagcaattg ctgaaccggc ttcttccgct ttcgcatcag gaatcacaaa 2195161 gccttgcagg tcatcatttg atttgaaata cccttctgca acaatgtctt caataatcgc 2195221 ggcatcgaag cggtcagatt tgatttcctg caccaaatca gaaattctgt tgcggtcttc 2195281 tgttttaaaa ccatattccg gagaaagctc tttccccttc tcttcctgaa tagagccaag 2195341 ctgaacgcca actgtttttc ctttcaggtc tttcaaagat tgaatgccgc tgtctttttt 2195401 gctgacaatc atatggttcg ctgtgtaata cacatcggaa aaatcaactt gttttttacg 2195461 ctcaggcgtt ggtgtcattc ctgacagaac gagatccacc tgttttgatt taagcgctgt 2195521 aattaagctg ttgaagtcca tatcctgcac ttcaatttca tagcctgcct tctttgccag 2195581 agcttttgcc agctctacat caaagccgac aatattatct ccttctttat attcaaacgg 2195641 tttgtaatcc gccgaagtac ccataattaa ttttttcttt ccgctttctg aacctgaatt 2195701 gcttgagccg cacgcagtta atgcaaaggt gatgcaagca gccacaagta ataagagcca 2195761 ttttttcatg atccatttcc cccgtattca ttacttttgg tgtatttgaa tatttattcg 2195821 ttaatttgta ttttaaacag tttctcattt ttatgcaata ctatttttaa aaattatctt 2195881 taggcttatc tttccagtga tctcttctga tattactaga taaaaattaa atcgctgtac 2195941 aatccgattg aataatccct taatatttat tcatatatcc ttggaaattt atgcacaaaa 2196001 aaacccgggc tgctttgagc atccgggttg ttcgtcttat acttcttcac aatattcttc 2196061 aaaggcttcc tgcagctttg ccactacagc catcggctca tggccttcaa tttcatgacg 2196121 ctctaccatt ttcatgatct ttccgtcttt caaaatcgca aaggacggag aagatggtgg 2196181 ataaccttca aaatagtcac gcgcacgcgc tgtcgcttct ttatcctgtc cggcaaaaac 2196241 ggtgacgagc tgatcaggtc ttttatcata gtgaacggaa tggtaggctg ccggtcttgc 2196301 aattcctccg gcgcatccgc aaacagagtt taccatgacg agcgtcgttc cttttttcgt 2196361 aagtgcctca tccacctctt cggctgtttt aagctcggtg tatccggcag ctgttatttc 2196421 ttgtctcgct tggcggacaa tatcattcat aaataaatta aagtccatgt tcaatgaaga 2196481 cctctccttt ttcatcatct gttcttatga tagcaaggaa acgtccatat cggcaaatga 2196541 ctttgcttcg ccgtgcactt tttttgctct tcgtttactg cttacagaaa aaggggatta 2196601 tataaccaga agtaaaataa aggagcagtt gtatatgagc caccggaaag cgttactgat 2196661 tcataacgga aatgccggca acaaaaatat agaaaaagca cttggtgctg tggtgccggt 2196721 tttatctcac catttagatg aggtgattat taaacagaca aagaaaaagg atgatgcgta 2196781 tcatttttgc cgatccattg atgattctgt cgacaccgtc ttcattctcg gcggcgacgg 2196841 cacgatccat caatgcataa atgctatcag cgctctagaa agaaaacccg ctgtcggaat 2196901 tttgcccggc ggcacgtgca acgacttttc aagagtgctt ggcatccctc aaaatcttgc 2196961 aaaggccgcg gaagcactta tggcgggaaa aaaaaccagc gtagacgtat gtcagatgaa 2197021 tgaccgttat tttttgaatt tctgggggat cggcttaatt gcagaaacgt cgaatcaaat 2197081 caacgaaacg gaaaaagcat tattgggaaa aatcagctat tttacaagtg ccttgcgaac 2197141 cgtctcatct gctgcatcgt ttccgatgac attaaaaatt gatggagaag aaattaaaga 2197201 agaagccgtt atgctgcttg tgatgaatgg ccaatacatt ggaacgaatc gaattcctct 2197261 gcccgatgcc agtattgaag acggcttact tgatgttctc atatgccgca ataccaacct 2197321 caccgcgctg cgggagctga tgagcatgga acaaggctca attgatcgtt ttactggaga 2197381 gttgtcctat gtccaggctt cccgtatcga gattgaaaca gacactgcca aaaaggcgga 2197441 tatggatgga gaagtttata cacatacacc cgcagtcatt caggtcctgc cacagcatat 2197501 cgacatgctt gttcccgcaa atgaataact gtcataaggc tttagaaaga ttttgcaaat 2197561 ccgttgactc tcccctagga ggaggtctta cagtataagg gatacacact tgaaaaaggg 2197621 gaagtcatat ggagaagaaa aatattacct taactatatt attaaccaat ttatttattg 2197681 cttttttggg gatcgggctt gtgattccag taacgccgac cattatgaat gaattgcatt 2197741 tatcggggac cgcggtcggc tatatggttg cctgcttcgc tattacacag ctcattgtct 2197801 caccaatagc cggacgatgg gttgatcgct tcgggcgcaa gatcatgatc gtaatcggcc 2197861 tgttgttctt tagtgtgtcg gagtttttgt tcggcattgg aaaaacagtt gagatgttat 2197921 ttatctcccg tatgctgggc ggtatcagcg cagccttcat tatgcccggg gtcacggctt 2197981 ttattgcaga tatcacgacc attaaaacac ggccaaaagc gctcggttat atgtcagccg 2198041 ctatttcaac aggatttatt atcggccccg gcatcggggg atttttagca gaagtccatt 2198101 cccggctgcc ttttttcttt gcggcagctt ttgcactgtt agcagccatt ttatcaatcc 2198161 tcacgctgcg cgagccggaa cgaaaccctg aaaatcagga aataaaagga cagaagacag 2198221 gctttaaacg aatttttgcc cccatgtatt tcatagcttt tctcattatc ttaatttcgt 2198281 cttttggttt agcatcattt gaatctttat ttgcattatt cgtggatcat aaattcggat 2198341 ttacggccag cgacattgcc attatgatta caggaggagc gattgttggc gccattacgc 2198401 aagtcgtctt attcgaccgc ttcacaagat ggtttggcga aattcattta attcggtaca 2198461 gcttaattct ctcgacgagt ctggtattct tgctgacaac ggtacattca tatgttgcga 2198521 ttctgctggt gacagtcacc gtatttgtcg gatttgatct catgcggcct gcggtaacga 2198581 cttacctgtc aaagattgcg ggaaatgaac aggggtttgc cggcggtatg aattcaatgt 2198641 ttacaagtat cggcaatgta ttcgggccta ttatcggcgg aatgctgttc gatatagatg 2198701 taaactatcc tttctacttt gcaacggtca ccttagccat agggattgca ctgaccattg 2198761 cttggaaagc gcctgcacat cttaaagcca gcacgtgata agaagcgcat tctttgtgta 2198821 ctgcaaagaa tgcgcttctt ctttatactg atgatagaag gagtgatggc atgaaggaat 2198881 cgtattactc aattggggaa gtatcaaaac tggcaaacgt gtcgataaaa gcgctccgtt 2198941 attacgataa aattgattta tttaaaccag cctacgtcga cccggatacc agctaccgct 2199001 attatacaga ttctcagctc attcatctgg atttgatcaa atcattgaaa tatatcggca 2199061 cacctttaga agagatgaaa aaagcacagg acttagagat ggaagaactg tttgcttttt 2199121 atacagagca ggagaggcaa atcagggaga aattagactt tttatcagcc ctggagcaaa 2199181 ccatttcatt ggtgaaaaag cggatgaaac ggcagatgga atatcccgcg ctcggtgagg 2199241 tgtttgtttt agatgaagaa gaaatacgga tcattcagac agaggcagaa ggaatcgggc 2199301 ctgaaaacgt gctcaacgcc tcctacagca aattaaaaaa atttatcgag tcagcagatg 2199361 gatttacgaa caatagctac ggcgctactt tctcttttca gccctacacc agcattgatg 2199421 aaatgactta ccgtcatatt ttcacacctg tattgacgaa taaacagatt tcatcaatta 2199481 cgccggatat ggaaatcaca acgatcccta aagggaggta tgcgtgtatc gcgtataatt 2199541 tttcgcctga acattatttt ctcaacttac agaagcttat caaatatatc gcggaccgcc 2199601 aattaacagt tgtcagtgat gtatacgagt taatcatacc gattcattac tccccgaaaa 2199661 aacaagaaga atatcgagtc gaaatgaaaa tacggatcgc tgaataataa agcatagaaa 2199721 aagagcattt tttgaaacaa aacttcaaaa aatgctcttt ttgcttattt agtaaacaga 2199781 tgtcttctcg tcaatcgatt ctaaaatttg tttcactcgt ccgaggaatc gtccgcacac 2199841 gagaccgtca agcactctgt gatctaatga caggcacaga ttaaccatgt ctctgacagc 2199901 aatcatgcca ttgtccatga caaccgggcg tttgacgatg gattctactt gaagaatcgc 2199961 agcctgaggg tagttgataa tgcccatcga ctgaacagac ccgaacgaac ctgtgttgtt 2200021 gacggtaaac gtgcctccct gcatgtcatc tgcagtgagt tttccgtctc ttactttttt 2200081 agctaggccg gtaatgtctt tcgcaatgcc tttaattgtt ttttcatcag cgtttttaat 2200141 caccggaaca aataaagaat cctctgtggc aactgcaatt gaaatattga tatccttttt 2200201 ctgaataatt ttgtcccccg cccacatgct attcatttgc gggaattctt ttaacgcctg 2200261 agcgaccgct tttacaaaaa aggcgaagaa cgttaaatta aagccttctg tcttcttaaa 2200321 agaatctttt atactgttgc gatatgcaac catatttgtg acgtcgactt ccatcatcgt 2200381 ccaagcatgc ggaatttctg ttttgcttcg cttcatattg gaagcaattg cttttcttac 2200441 acctgtgaca gggatttctt tatcaccggc tgcagacgca ggatatgacg tctcttcttt 2200501 tggctcaggt tttgatgcag acttcggtgc aggagctgct gttttcagct cctcaggatt 2200561 ctgttcttgc acgccgcctg tttcaattaa gcgctgaata tcttttcgtg tgatgcgccc 2200621 gccggcacca gttcctgtca cttgatcgag gtcaatgccg tgctctccgg ccaaacggag 2200681 aacagctggc gagtagcgct ttttattggg ctgatcggct gctccagcac tttttgcaac 2200741 agggttctca gcggcttctg atgctgctgg ctgttcttgt ttttgttcag ccggattcgc 2200801 gccttctgtt tcaattttgc aaatcatttc tccgacttgc agggtttggc cttcttctcc 2200861 cacaagctct gttatcgtac cagtaaaaga agacggaacc tctgcattta ccttatctgt 2200921 catgacttcc gcgatcggat cgtatttgtt cactttatca ccgggggcga caagccattt 2200981 gctgatcgtc ccctctgtta cgctttctcc aagctgcggc atcgtcattt gttcaattgc 2201041 catgattgta tcctccctta cgtctttaaa actccgctaa ttctctcatc gccgcttcca 2201101 ctttatcagg gttgaccata aagtattttt ccattgtcgg cgcataaggc atagccggaa 2201161 tatcaggacc tgcaagccgt ttgatcggcg cgtctaagtc gaacagacaa tgctcggata 2201221 taattgcggc tacttcgctc atgatgctgc cttcttttgt atcttctgtg accaaaagaa 2201281 cctttccagt tttggacgca gcttcgatga tggcttcttt atcaagcggg taaactgttc 2201341 ttaaatccac cacatgcgct gaaatgccat ctttttcgag acgttctgca gcttgtaagg 2201401 cgaagtggac acacaggccg tatgtgatca ctgtgatgtc gtcgccttcc ctttttacgt 2201461 ccgccttgcc gattggcagg acataatcat cagccggaac ctcgcccttt atcagacggt 2201521 atgcccgctt gtgctcaaaa aacagcacgg ggtcttcgtc acgaactgcg gcttttaaga 2201581 gccctttcgc gtcatatggt gttgatggca tgacaatttt cagtccgggc tggttggcga 2201641 aaattgcttc gactgattga gaatgataca gggctccgtg cacgcctccg ccgtatggcg 2201701 ctctgacgac aatcggacag ctccagtcat tgttgctgcg gtagcggatt ttagccgctt 2201761 cagaaataat ttggttgact gccggcataa tgaaatcagc aaactgcatt tcagcaatcg 2201821 gtctcattcc gtacattgcc gctccgatac cgactcctgc gattgcagat tcagcaagcg 2201881 gcgtatccat aacgcgctct tccccaaatt gttcatagag tcccgctgtc gctttaaaca 2201941 caccgccttt tcttcctaca tcttccccaa ggacgaaaac gcgagaatct cgttccattt 2202001 cttctttcat cgccaaattg attgcatcaa tatatgacat tactgacatt tgttcttcct 2202061 ccctacttcg cataaacata atcaagcgct gactcaggag ctgcatatgg ggcgttctcc 2202121 gcttcatccg tcgcttcatt tacgattgcc ataatttcat ccagcatggt ttgttctatc 2202181 tcatcggaca gcaggcctgt ttcctttaag taagcttgat aagtaagcag gggatcactt 2202241 tttttcgctt cctctacttc ttcacggcct ctgtagctgc tgtcatcgtc atcactggaa 2202301 tgtggtgtaa ggcggtaaga aatcgtttca attaatgtcg ggccttctcc tctgcgtgcc 2202361 ctttcgcgtg cttctttaac cgcttgataa acttccagcg gatcatttcc attcacagtt 2202421 acgccaggca tcccatagcc tatggcacgg tcggaaatgt tctcacatgc gacttgctta 2202481 tcgtaaggca ctgagattgc gtatttgttg ttttcacaca tgaaaataac cggcagctta 2202541 tggacagcgg caaagtttgc cccttcatgg aaatcgcctt ggtttgaaga cccttccccg 2202601 aatgtaacaa aggctgcgat atcctttttc tccatacgtc ccgcaagcgc aataccgact 2202661 gcgtgcggca cttgcgttgt aaccggagat gatcccgtca caatgcggtt tttcttttgt 2202721 ccgaaatgtc ccggcatctg gcggcctcct gagttcggat ctgctgcttt tgcaaacccg 2202781 gacatcatta agtcctttgc tgtcatgcca aacgcgagca cgacacccat gtctctgtag 2202841 tacggcaata cataatccat ttcacggtca agtgcgaaag ccgctcctac ctgtgctgct 2202901 tcctgtcctt gacaagagat tacaaatgga attttgccag aacggtttaa cagccacatt 2202961 ctttcatcga tttttcttgc taacagcatg gttctataca tatcaacggc ttcctgatca 2203021 gtcagcccta gtgcttgatg tcggtttgta ctcattcaag cccctccttt atgcttttaa 2203081 aaatgaatgg ctttgccatc tgcggcaagc gcagcttctc caattgcttc agaaagcgtt 2203141 ggatgcgggt gaatcgtttg cccgacctcc cacggtgttg cgtccagcac tttggcaaga 2203201 cccgcttcag aaatcatgtc ggtgacatgc gggccaatca tatgaacgcc gagaatatca 2203261 tctgtatctc ggtcagccac gattttgaca aaaccgtcgc tttcaccgta tacaagcgct 2203321 tttccaatcg ccataaatgg gaacttgccg attttgacat tatgcccgtt cgcctttgct 2203381 tcgtcttcgg ttaagccgac actggcagct tcagggcttg agtaaatgca cttcggcaca 2203441 agcgtcggat caagcggatg cggattgaga cctgcaaaat gctcaacagc aataattccc 2203501 tcatgtgaag caacgtgagc taactgcagg ccaccgatta cgtctccgat tgcataaata 2203561 tgagattcct tcgtttggca gctttcattg actgaaatca tgccattttc agtaacaata 2203621 tcggtgttct ctaggccgat gccttcgata tttgcctgtc tgccgatgga aacaagcatt 2203681 ttctcagcag aataggtaac ggtttctccg tctttttccg cttgtatgct gatatcgtct 2203741 gatgtttttg tcattgtgtc aggcagcact tttgcccctg ttatgaactg gatgcctttt 2203801 ttcttaagaa gactttccat ttcttttgaa atctctagat cttcagtcgg caatatgcga 2203861 tccgcgtatt caataaccgt taccttaacg ccaaaatcat gaagcataga cgcccattcg 2203921 ataccgataa cccctccgcc gacaatgatg attgactgtg gcagctcctc catttggagc 2203981 gcctcatctg aagtcagtac agacttaccg tccacttcaa gacccggaag cattctcggt 2204041 cttgatcctg ttgcaatgat cacttgtttc gggatcagca tgtcattttc ttcgccattt 2204101 ccccgctcaa cagaaattgt tcccggcagc ggagagaaga ttgacggtcc aaggatacgt 2204161 ccatatccgg tgtacacgtc aatttttcct tttttcatta aatgatttac acccgctgca 2204221 agcttatcaa caacggcttg cttacgctgc tgcacttttt caaagttgag ggacacgcca 2204281 gccgtttcca ctccgaattg atcggcttca cgagctgtcc ggtatacctc tgcgcttcta 2204341 agcagcgctt tactcgggat acagccttta tgcagacatg ttcccccgag tttttccttt 2204401 tccacaacgg ctgtttttaa gccgagctga gcggctctga tggccgcaac ataaccgccg 2204461 gtaccgccgc ccagaatgac tacgtcatac tcagttgcca tggtgactca ctcctgtctg 2204521 tctattcaat acgatattgt ttggattgct cttcgccctg caatactctt agcgcccctt 2204581 gggcaagaga ctgcagttca ttttcacccg gataaactaa aacgtctgaa atccaatcta 2204641 tgtatgatct gatagcagaa acaaagcttt ttccgtacgc aaggcctccc gtcagcacaa 2204701 tcgcttcaac ttcgcctttt aacgccgcgc tggctgcccc gatttccttt gctacctgat 2204761 atgccatggc atcataaatg aagcgggctt tttcatcgcc cccttgaatc atctgttcca 2204821 cttttactgc atcatttgta ccgagatagc ctaaaagtcc gccggtgcca acaagctttt 2204881 tcatgatttc ttcttttgta tattcccctg aaaaacatag atcaacaaga tctcccgcag 2204941 gcactgttcc tgctcgttca ggactgaatg gtccctcgcc gtgcaggccg ttattgacat 2205001 ccaccactcg cccgcggtca tggacgccaa ttgtaatacc tccgcccata tgggtaataa 2205061 tcattttcat gttctcatat cgtttgccaa gggaggctgc cgctttacga gcgacagctt 2205121 tttggtttaa cgcatggaaa atgcttttcc tttcaatttc aggcatgcct gaaactttcg 2205181 caagcactga catttcgtct acgacaacag ggtcgacgat atacgaaggg atattcaggc 2205241 cgtcagcgat ttcccgcgcg ataatgccgc cgagattaga agcatgctga ccggcgtagc 2205301 cgcttttcaa atcctcaatc atctcatcat tcactacgta ggtcccgcct tcaattggcc 2205361 ggagaaggcc gcctcttgcg cagactgcat caaactttga aatattgatt ccctgttcat 2205421 gaagcgtttc gagaatatgg tttttacgaa attcatactg atcaataatt cggtcaaatc 2205481 gctgcagctc ttctatgttg tgtctcaatg ttttttcaaa aatgcttctt tcgttatgaa 2205541 aaacaccgat tttcgttgaa gttgagcctg gattaattgt gagaatgcgt ttttcgtcat 2205601 gtagcacttt cataacctcc agatcaattt cttaacgtct gcttaataca ctgtggccgt 2205661 tttgcaaaaa ctggcttctt gagcggcgca tgcgttcaat ccgttcctct gctaagcggt 2205721 cagccgctaa atatgcagga atgccgtcac gctgagaaat ctcaagtaca cgctcgatat 2205781 tgccgtaaat gccttcaact tttttcaatg cacgttctgc attatagccg taaagctcat 2205841 ctgccacgtt gatgacaccg cccgcgttaa tcacgtaatc cggtgcataa acgatgccca 2205901 tttcgtgaat ttgatcacca tggcgtgtct cttttaattg gttgttagcc gcacctgcga 2205961 tcactttcgc cttcagctgt ttaatggtgt cgtcgttaat agtcgcacca agggcacacg 2206021 gcgcataaat atcgcagtct tgtgaataaa tgtcatcagg atctaccgca cgggcgccaa 2206081 aatcttcaac tgcacgctgt acagattgtt tgttgatatc cgtaacgatt aagtttgctc 2206141 cttcttcatg caggtggcgg caaaggttat aggctacgtt cccaacaccc tgtacagcaa 2206201 tggtttttcc ttcaagagag tcggttccga aagcagcttt agctgctgcc ttcattcctc 2206261 tgtacacccc gtacgctgtg actggggacg gatttccaga agagccgaaa gcaggagaaa 2206321 tccctgtgac atagtctgtc tcatcatgaa tgatatccat atcctcgacc gttgtgccca 2206381 catcttcagc cgtgatgtat ctgccattca gtccttgaat atagcggcca aacgcgcgga 2206441 acatttcctc atttttgtct ttgcgcggat cgccgataat gactgttttt ccgccgccaa 2206501 ggtttaagcc tgccgccgcg ttcttatagg tcatgcctct tgccaatctg agcgcatctt 2206561 caattgccgc ttcttcattt tcatatgtcc acattctcgt tccgccaagc gccggaccaa 2206621 gcgttgtatc atgaatggcg ataatcgctt ttaatccaga ttgttcatcc tggcagaata 2206681 ccaattgttc gtaatcgtat ttctccatat atttaaaaag ttccatgttc gttcctccta 2206741 atgtgtgtat tcttcagatg cgcatattgc cagcgcaatg gaatacagtt tattttcagc 2206801 agagtccgct ctgcttgtta aagcaatcgg tgcttttgct cctgtaatga cagccgccac 2206861 gctggccttg gcaaaataaa tcagtgattt atataaaata ttgccggcct caattgttgg 2206921 gacgagaagg atatctgcgt tgcccgctac gtctcccgaa atttttttct gggccgcggc 2206981 aatttgtgaa actgcgttat ccaaagcaag cggtccatca acaatgcagc ctttgatctg 2207041 gccccttttg tacatttgag ctagagcagc tgcattcacg gtcgcttcca ttttagggtt 2207101 caccgtttcg accgctgcaa gggcagctgc ttttggcata ttgttcccca ctgcatgggc 2207161 cacatgaacg gcattttgca aaatctgccg gagctcttcc agcgaaggag caatattcat 2207221 tgccgaatct gtcacaaaca tcagccggtc aaaatccggt atatcgaaga cagccacgtg 2207281 agaaaggaca cttgctgacc gaagcccctc ctgtctgttc aataccgctt taagcaaaac 2207341 agaagtcggc acattgcctt tcattaaaac gtccgctgtt ttatgatgca cagcacgaac 2207401 cgctaatttc gccgattcct caggagtatt ggcatggacg atttccactt gatgcccttg 2207461 catggatgat gtcagctcgt tcagtttttt gctgtcgccc gttaacaaga aacgggcgga 2207521 taggtgctcg gctgccagct ttacagcccg gatcacttcc tcatcctcag catgagcaac 2207581 cgcaatggtc ttatttttgt gtatcgacgc tttgccgatt aaatctttca gcttcatctg 2207641 ttaccacctt tcttgtttcg actccgcctt ttattatgca agttccatgc cagctcttaa 2207701 gggtgctgtc ataccaggta taccgaaaca ttcgtgcaga tgtttgcgtt tattctgcaa 2207761 attattgcat gccttcattt gcaaggccat atttatccat tttgtaatat aaattccgaa 2207821 tgctgacacc gagagctttt gctgtttttg tccggttaaa atgatgcttt tcaagcgttt 2207881 gctggatcaa atgcgcttca aatttttcta ctgcgacaga cagcttttcg ccttcaatat 2207941 ccggaaaatc aaaacctgtt ccctgatctg tgtcattttc tttttgctca agttcgaata 2208001 caggcaagtg atctttttca atccattcca tatgcggatt cagaaaaatc atggctcgtc 2208061 caaggacatt ttcaagctcc cggacattcc caggccaatg gtaggcagat aaggcgcgca 2208121 aggcttgctg tgagagccct tttacattcc tgccgtaatc ccggttgatc ttttggataa 2208181 gtctgacgct caatgcttca atgtcctcca accgctgccg caaaggcggg atggagatcg 2208241 gatagcgatt gatccggtaa tacaggtctt cccggaatgt tccgtccgcc atcgcctttt 2208301 caatatttac atttgtcgcc gcgatcactc tgacgttgac agggatcgct ttcgtgccgc 2208361 ccactctgac gatttccttt tcttgaagga cgcgtagcaa tttggcctgc atattttgtg 2208421 tcagctcacc gatttcatct aagaaaatac tgccgttatt tgcttcctca aataaaccct 2208481 ttttaccgcc gcgcttcgct cctgaaaacg caccatcctc atagccgaac aattctgatt 2208541 cgagcaggtt ttcagaaagg gctgcacaat tcacgcgaat aaatttattg tatttccggt 2208601 cactttcgtt atggatggca tgggcgaaca gttcttttcc tgttcctgat tccccgcgca 2208661 gcaagatggt tgccggtgtt ttcgcaccga gcttcgcctg ctcaagcgca accagcattt 2208721 gctcgctttt gccgataatg tcgtcaaacg tgtatttcgc ttcaagcgtg cgaataattt 2208781 gtctggcgcg attaagctcc gctgtcagca ttttaatttc ggaaacatcg tgaatcacgc 2208841 cgacgctgcc tttcaaaatc ccgtccacaa tcaccggtgc tacattaacg atcacttctt 2208901 tttcattcgg gccgaccttc attctgacac cgcggacagg acgtcttgtt tcaagcacct 2208961 ttaaatgcat gctttcgcct tcggaaatat cagtgtttgc aggcttgccg atgacttctt 2209021 tttcagaaag ccccgtcatt ttcgtatacg ctttattgat tagcaggccg atgccgtttt 2209081 catcaacgac agaaatcgcc tcatcggagg attgaataat tgcctccagc atcgtacgga 2209141 cctgctttaa gttggtcact tcctctgcca gctcgaccgc atcagtgata tctttaaaca 2209201 cacaaagagc cccgagcaga cgtccgcctt catcaataat cggcagtctt gtggtcacaa 2209261 tttgcaaatg atcgcctaac agctgcttct ggttgtattc aggcactctt gtttttaaaa 2209321 tccgcggcat cttagtgctc ggaatcactt cttttattgg gcgcccaatg acttcctcac 2209381 gtttttttcc gaccattttt tcggccatat ggttaaagag aatgatttct tcattgatat 2209441 caataaaaat cattccatca tgggtggaat taaaaattct gtcatattta taggtttgct 2209501 cttttagcat ttgaatcagg tgctgctttt cttccatcag ctgaaaaacg atgtatgcca 2209561 tttttcccgg catgacaatg gtatcttcat gctttctttg aaggagctcg tcaaacacgg 2209621 cttgatcgcc ggtagtatga atgacgatat ccggtttttg ttgtatgtaa ggtttccaat 2209681 cagatgatac ggcaatccca tactgttctg cttctttcaa tcccggcgcc tcggggtctt 2209741 tgtcaactac ggcaatgata tctatgatgg ctgttttaat cagaatatgt aataacgccg 2209801 ttcccctttt gccggcacct actatcagta ccttttgcat cccgataccc ctttgtatga 2209861 aaaaatttgc acacctattt attccgttgc aataatttgc acaaccctat gttaccacgt 2209921 tttcttctct tgacaaaata ttttttccgc tggacaataa aggaaatgaa aagataaagg 2209981 ggttttctga agatgagccg acttcttgcg cttttaatat tagtcatccc cggggctatt 2210041 tctgctttag gcattaaact gatgagagat acacttttcg gccatacaat caagccattt 2210101 tcagctcttt ggctccaagg gttgtcagga ttcatctttt ttgcgatcgg cctctatgtg 2210161 ctggccgggt tcattttata cagagacaga aaacgcaatc aagtcagccc gcgattcaga 2210221 aaacgatagc tgaaaaaaag ccggagaatg ctccggcttt ttttgttgca ttattcgtca 2210281 ggcaaaacgg tcttggcaat cgttttgtct aacgcttcat agtcataata agaaatcgta 2210341 tcgtacagtt cttttcgtgt ctgcatatca tgaagtcctt ctttttgtga gccgtgctcc 2210401 ttcatcaaac caaacatccg ctcacaagct tttgccgccg ctcgaagcga ggtgacagga 2210461 tatatcacca tgtgaaaccc catatcttcg aattcatcgg cacgataata tggcgttttc 2210521 ccaaattcag tcatattcgc aaggagcgga acggggatac gctcagcaaa ctggcggaat 2210581 tcattctccg cctgtagcgc ttccgggaaa attgcgtccg ctcccgcctc aatgtaagcc 2210641 tctgaacgtt ttattgcggc atcaagccct tcctgcgccc tggcatcagt acgggcaaca 2210701 acaataaggg agggtgccgc ttgtttaatg gcttttattt tttgcgccat ttcctttatc 2210761 ggaactagct gtttgccatt taaatgtccg catttttttg ggagctgctg gtcttccatt 2210821 tgaacggctg ctaccctggc ttcaagcatc tcccgggctg ttcgggcggc atttaagaca 2210881 ccgccaaatc ccgtatcgat atccacaagc aaaggcagat cagctgcacg cacaagatct 2210941 ttggcccgtt cagctatctc tgccgatgtg atgatcccta aatcaggcag ccccctgctg 2211001 gctgtatagg cagcaccgga caaataaata gcagaaaaac cggcttcttt cgcaagcaaa 2211061 gcggccatcc cgtcatgggc gccgggaatt tgaagaatgt ccggtgctga catcagcttg 2211121 cggaaacgcc cggcaagctc ctcttgtgac gattgcttat tgacgatcca cgacatgaaa 2211181 caaaatcccc cttttacatg cagaacatgt ctacgaattc atttacgcgc atcgtttgta 2211241 atgtctcata gctggtacag cgctcataaa tgtgtttgtg ctgtttatca ggaaaatggg 2211301 ttttgagatt gtcagaaaac ttttccagca gtttcggcac tgcttcctct cttcgaaaac 2211361 gatggccgag gggaaactca cattccacca tttccgtgct cgttccatct ttaaaatgaa 2211421 cctgaacggc atttgagatg gagcgtttat caggcttcaa ataatcctcg gtatatgttt 2211481 tattttcagt cacttccatt ttatcacgaa gtttatctat tctcggatca ttcgctgttt 2211541 cagcttcata atgctgtgcg gtgatatcac caaaaagcaa accgattgct gtaatgtatt 2211601 ggaggcagtg atcacggtct gccggattgt ggagcgggcc ttttttatca atgattcgga 2211661 tagctgattc atgcgttctg atgacaactc ggtcaatctc gtcaatccgg ttctttacct 2211721 gcgggtgaag aatgacggcg gactccgccg ctgtctgggc gtgaaattcc gcaggataag 2211781 acactttaaa taacacattt tccatgacat aagcgtcgag cggacgggca agcttgatct 2211841 ctttcttatt gaataaaacg tcttggaacc cccaacccgg tgcactcaag gctgtcggat 2211901 aacccatttc cccttttaac gacatcagcg ccaaatgaac acctctgctc gttgcatctc 2211961 ctgccgccca tgatttacgc gagcctgtat tcggtgaatg gcggtatgtc ctcaatgctg 2212021 cattgtcaat ccatgcattc gaaagcgcat ttttgatttc ttctcttccg ccgcccaaaa 2212081 gctttgctgc aacagcagtt gtcgcaactt tgacaaacag cacatggtca aggccaactc 2212141 gatttaagct gttttctaac gccagcacac cttggatctc gtgtgctttg atcatcatct 2212201 caagtacgtc gcgtaccgtt aacggctctt ttccttcaga cagcctcact cttgatacat 2212261 aatcagcagc ggcaaggatt cctcccaagt tatcggatgg atgcccccac tccgccgcca 2212321 gccacgtatc gttgtaatcg agccagcgaa tcatgcagcc aatattaaac gctgccctca 2212381 caggatcgag aacatatgac gttcccggca ctttgcttcc attcggcaca gtcgttcctg 2212441 gaacaatcgg gccaagcagc tttgtgcatt ccggataccg tagcgccaag attccgcagc 2212501 ccagggtatc cagcaataca tgccccgctg ttgtatacgc ttcggcacta gtaatctctt 2212561 tctcaagcac atagtctgtg atttcttcga taacacgatc cgttttcggc attctaccag 2212621 ctcctttcat gattttgttt gatatcgcgg gcccatgtaa ctgacacggg gacggaagag 2212681 ccgattattg gcatgctgtt cgatcacatg ggcgcataaa ccggacgttc tcgcgctgaa 2212741 aaagatcggc gtatataaag gaatcggtat gccgagcatc caatacactg gggcagcata 2212801 gtaatccaaa ttcgggtaaa gccctttttc cttctccatc agccgctcac ccgcttcgca 2212861 catctcatat aaacgatggt caccggcttt atcgcataat tgctgcagcg cctctttcat 2212921 catgagtgct ctcgggtcca tttttttcat atacacccgg tggccgaagc ccatgatttt 2212981 ttcttttctt ttcagttttg tttgcaaaag ctgctcaaaa tcagatgtcg tttttgcctc 2213041 caaaagcaaa tacatcacag cttcgtttgc tcctccgtga agattccctt tcagggaagc 2213101 gacagcccca gtcaaagccc cataaagatc tgaatgtgta gatgcaatga ccctggccgc 2213161 aaaggttgaa ttcggcatct catgctcact gtacaggacg agcgaccggt caaaaatctg 2213221 ttcttccaat gaagacggca atttccctgt catcatgtag agaaaattcg cactgtagga 2213281 tagggtttga agcggaagaa tcggttcttt cttattaatg atcctgtagc tggcagcagt 2213341 gagggcaggc attttcccaa gaagctgata ggcgcgttct ttgtttgcgg aaggagaccg 2213401 atcatcaatt tgccgatcat agccagcaag tgccgacagg ccggtacgca gaccatccat 2213461 tggatgagtg tcctcaggga gcagctcaag cagacggaga tgatcagcag gcaggcttga 2213521 ggcactgttt attttacgtt ccagcgtttc catttcactt tcttctggca gcctgccctc 2213581 cagcaataaa tggacaagct ccagatagct ttttgtttca gaaagttcta ttaaatcata 2213641 gcctcttatc aaaatctggc tggactgcgt gtcaagataa gaaatatgag tttctgccgc 2213701 aatcacaccg tccaaccctg gagaataatg ctgtttctcc tccatatcct caacctccgt 2213761 ttttgcgttt tttgtctatc aggttccgcc aagcaaatac ttggaaataa tcagtctttg 2213821 aatctcgttc gtcccttcat aaatttgcgt cacctttgca tcgcgaagca ggcgctcaac 2213881 tggataatcc ttcatatagc catatccccc ataaatttga acggcgtcta acgccgcctt 2213941 tacggctgca tcggaagcaa attgtttagc catagacgct tcttttccac agtttaggcc 2214001 gcggttatga aggtctgcag cgtggtagac aagatgtctt gccgcctcag ctctagtcgc 2214061 catatcagcc agcttaaatg atatgccttg attggctgca atcggccttc caaattgcac 2214121 tcgctgcttc gcataatcaa cggcatgctc aagagccgcc tctgcaattc cgagggcctg 2214181 tgccgcaatg ccgatccggc cgacatttaa attcgccatg gcaatgtgaa agccatcccc 2214241 ctctttgcca agcaaattgg cttcaggcac ttctgcatta tcaaaaatca gttccgtagt 2214301 attggagcca taaagcccca gctttctttc tttttttcca acggtaaaac cgggtgtgtt 2214361 tttttcaaca ataaaagccg aaatcccgtg cctgccttga tctggagctg ttaaagcaaa 2214421 tgtgatatag atatcagctg ctccgccatt cgttatgaat attttcgatc cgtttaatag 2214481 gtatttgccg ttctttttga ttgctgttgt gcggaggctc ccggcatccg accccgagtg 2214541 aggctccgtt agtgcaaatg cgcccaaatg gtctcctgac gcgagatttg gtatatattt 2214601 catcttctgt tcttcgttgc cgaaatacag aatcggattc gtgccgactg aggtatgaac 2214661 ggagagaatc acgccgacag ccgcgctgat tctagaaatc tcatgaattg ccaaaatata 2214721 agaaacaacg tccgctccag caccgccgta ttgttccggc accggtattc ccatcagtcc 2214781 gtgtttaccc atttttttga tcagctgaaa gggaaattcg tccgttttct ccatgatttc 2214841 cgcagcggga gcaatttctt ttcgtgcaaa atcacgcacc atttttcgca tcatgacttg 2214901 ctcttgggtt acatgcaact cggccacccc cggatggaat agacttcagg aagtcttctc 2214961 ctcatagtca taaaaaccgc gtccgctctt tttgccaagc cagcctgctt tgacatactt 2215021 gcggagcagc gggcaaggac ggtatttgga atcgccaagg cctgagtgaa ggacttccat 2215081 aattgataaa cacgtatcca gtccgataaa atccgctaat gcaagcggac ccatcggatg 2215141 attcatgccc agcttcatca cttcatctat tgcctccggc ttcgccactc cctcatacac 2215201 gcaatagatg gcttcattaa tcattggaag aagcacacgg ttggaaacaa acccaggaaa 2215261 atcattgact tctaccgctg ttttccccat cttttccgct aatgccataa catctaaggc 2215321 cgtttcttct gatgtagcca agcctcgaat cacttctacc agcttcatta cagggacggg 2215381 attcataaaa tgcatgccaa taacccgttg aggccggttt gttacagcag cgatttctgt 2215441 aataggcaag gaagatgtat tgctggccaa aatcgtatga ggcgggcaaa tgcgatcaag 2215501 tgttttaaac atctcagttt ttgccgccat gttttctgcg atagcctcaa tcacaatgtc 2215561 cgcatgctct gcctcctcaa gtgtttgaga aatcgaaatg cggttgatta cgctcttcac 2215621 ttccgtctcg gtcctttttc ctttctcagc atcacgggcc agctgtttct tcagccgttt 2215681 caatcctgcc tccgcggcct ctggattcac atcatacatc cgcacataaa agcccgcgtc 2215741 ggcggctgtt tgagcaattc cgctccccat ctgacctgcg ccagctacca tgatttgttt 2215801 gatttccatt caaatcccct ttttcatcat gttttaatga acctgcacta agacggcgtc 2215861 tccctgtgct gccccgctgc aaatagcggc aacgcccaga ccccctcccc gtcgctttaa 2215921 ttcataaaca agcgtcatga gaattctcgc accgctcgcg ccgatcgggt ggccgagcgc 2215981 gatcgcaccg ccattcacat ttactttttc aagatcgaaa cctacgattt tttcacatgt 2216041 caaaacaact gaagcaaaag cttcatttac ttcaaacaag tcaatatctt ggacagttaa 2216101 accattcttt ttcaggagct tgttaatagc aaaccctggc gctgccgcca gctcgtgcgc 2216161 tggcattccc gtagttgaaa aaccaagaat tgtagccaga ggccgtttgc caagctcagc 2216221 agctttttcc tcagacatca gcacgaacgc gccggctccg tcattgactc caggagcatt 2216281 gccggctgtg atagaaccgt cacttgcata aatcggagca agttttgcga gctgatccag 2216341 acttgtgtca cggcgaatcg cttcatcttt atcaacaacg tttggttttc cttttcgacc 2216401 gatccagttg acgggaacaa tttcatcctg aaacttccct tcatcggcgg ccttagctgc 2216461 ccttgcatga cttctcaacg cccattcgtc ctgctctctt cgtgagattg catattcctt 2216521 ggcagctgta tttccgtgaa cagccatgtg cacctcgtca aatgcgcacg ttaatccgtc 2216581 atacaccatt aagtccctaa gctcgccgtc ccccatccgt gctccccagc gcccggcggg 2216641 aacggcatac ggaatattgc tcatgctttc catccccccc gcaacaagta tgtccgcatc 2216701 ctgcgcccga atcatttgat cacataaagt gacagcgcga aggccggaag cacagacttt 2216761 attcagtgtt tctgacggca cactccaagg cattcccgcc agacgggcag cttgacggga 2216821 aggtatctgc cctgagccgg cctggacaac catgcccatg acgtttcctt ctacatcatc 2216881 tccagagact ccagcctgtt gcagcgcctc cttcatcaca atgcccccaa gctcagcagc 2216941 tttcacctct ttcaaaactc cgccgaattt gccaaatgga gttcttgcag cacttacaat 2217001 gactgttttc ctcatggttt cacctcattc agaagataga cagcgcttac aatttctagt 2217061 tgtcttctat gaatgtatgc tttgaaacgg gcatgaatga atgaaaaaag aaggctgcgt 2217121 caaacagcct ccttctaaca actattcatt tttcagcaat gccgaagcct tttctggaaa 2217181 gtcggtaaac atgccgtctg ctcccgcttc aatgagacgc ttcatatctt ccggacgatt 2217241 gactgtatac ggccttacct taatcaaacc gttcctcatt ttcttcagta cttcatctgt 2217301 gacccctggg ctgtttatct tcgggtgata gccggaagcc ggaatagacg cgatatatcg 2217361 atctgcctga taaagcacat ctgaagttaa tactgcccgt tcgatatgcg gtgcaagccg 2217421 ggcgcacagc gccaagctgt catgattaaa cgtggatagg atgactctgt cctctacatt 2217481 aaatcgcttc actgcctcca gcactttttc ttccattccc tcatagcgga tcacgctgtt 2217541 ttttaattca atgttgatga gaaaatcctt ttttaccgcc cacgagagca catcttctag 2217601 cagcggcact tttatatcgc tgtacgcttg atcgtgacca gcggccgcat tcgcagtctt 2217661 tacctcatca taggctgtat ccttcacgaa tcctttaagt gatgtcgtgc gattaagtct 2217721 ttcatcatga attacaacaa tgcgtccgtc tttcgtcagc tgtacatcaa gctctatccc 2217781 atccgctccg gcttcaattc ctttttcaaa tgcaagcatt gtattttcgg gaaattgacc 2217841 tgatgccccc cggtgggcaa aaatctttgt catcgtttca cctcaaaccc taaagttttc 2217901 tccattatac ttattttgtc ggctccactc taggattaag gctgtatcaa tctactgatc 2217961 ataataagaa tcaatgccat tgacaatcgc atctgcggcc ttttgctggt attcttcact 2218021 tcccagcttg tccgcgtcag agctgttcgt gataaaccca agctccgcca acacacttgg 2218081 catttgtgaa tatgtaatga cgtaaaagtc tgattctttc acgcccctgt ctctcgtttg 2218141 taaggaagaa acgagctgtg actgaatatc ggatgccaga cgccggctgt tctccccttc 2218201 ataatcagat tgaaaatacg tttctgttcc tgaagctgaa gcaacccctg aattcacatg 2218261 aatgctgaca aaaaggtcag cctgattggc acttgcctta gccactcttt cctccaaggt 2218321 cagaaaatga tcgtcagacc gggatgcaac aggattggct ccctcctctt ttagtttgtc 2218381 tgtcacatgc tctgagacag ccaaattaat atccttttca aagagcccgt ttccgaccgc 2218441 tccactgtct tcaccgccgt gtccggcatc aatatacact gttttccctt ctatcggctc 2218501 tgctgcctgt gcacaaggcg cgagcgtcaa agccaatccg cacagcgcca agctcctcca 2218561 taacattctc aacttactcc ctccggtcac gagttctttc gcagctgaat atcttccagc 2218621 tgtaaagttc cattatcctt ctttgtatat ttcaccagga catgtgtctg atctggcagt 2218681 gattcacatt catcacgttt atccttcgga acttgtatca tggtttcttc tccattaaga 2218741 gaaaccgcaa tcgtatgagg atcagccgag ccaatgtatt ttccctcttc ggtaaacctc 2218801 ggcactgagt catccgcact tgcaacactg caccccgaaa gaaagagcgc agtaaacagc 2218861 aaaagaaccg tttgtttcac atgaccacct cttcctgatg tttggctttt atctttgacc 2218921 agaatggaga atttgtaaag acaacgcgaa tgcaggcgag caagttccat gattttcaaa 2218981 agggctatac gacccgatca tttcctgttg ttagaaagat aacgagcaga tttgtctatg 2219041 aggatggctc taattgaggc gccaattaga aaaaattagc ggaaagaagc aactttttat 2219101 tcattttaaa aaatttgaga atagggtgag caaatcgttt gacgggtggg tcagccaagc 2219161 gtaacctttt aaaggatatt tactttattg aaagaagtta aagccatgaa aaaattcgtt 2219221 ctgctgctgg cggcagctgt catcacatgc tccatcggcc accaaatcag tggcggctac 2219281 aaaggccccg aaaaagagcg gccaaaacat cactctgcac tcaagatatt cagtcggtaa 2219341 agcagatcaa ttgcattaat ttttacatat aggctagaat atgtgcgaat ccaaacgaaa 2219401 gaagatgatc aaatgaatcc taagtataag ccactttttg aaccatttac gtttaaaagc 2219461 ggcgttacaa tcaacaaccg gatcgcagta gcaccgatga ctcattacgc ttctaatgaa 2219521 gacggtacaa tatctgaagc ggagctcgac tacatcatcc cccgttcaaa agagatggga 2219581 atggtgatta cagcctgcgc aaatgttaca ccggacggaa aagcattccc cgggcagccg 2219641 gccatccatg acgattccaa cattccaggt ttaaaaaagt tagcacaagc cattcaggca 2219701 caaggcgcta aagctgttgt acaaattcat cacggcggta ttgagtgccc gtctgagctc 2219761 gttcctcaac aggatgttgt ggggccaagt gacgtgtttg ataacggcaa acaaattgct 2219821 cgcgcattaa cagaagaaga agtggaaaac attgtgaagg cgtttggaga agcgacaaga 2219881 cgcgccattg aagccggctt tgacggtgtc gaaattcacg gtgcaaacgg ctacttaatt 2219941 cagcagtttt attctccgaa aaccaaccag cgcacggatc gctggggagg aagcgatgaa 2220001 aaacgattag ccttcccgct cgctattgtc gatgaagtga aaaaagccgc ttcagaacat 2220061 gcgaagggtg cattcttagt cggctaccgc ctgtctccgg aagaacctga gacaccggga 2220121 ttgacaatga ctgaaactta tacgcttgtt gatgctttag gggataaaga attggattat 2220181 cttcatatct cactgatgga cgtgaactca aaagcgcgcc gcggtgcaga tccgactcgc 2220241 acacgcatgg acttattgaa tgaacgtgtc ggaaacaaag tgccgctgat cgccgtcggt 2220301 tccatccatt ccgctgatga cgcgcttgcc gtcatcgaaa acggtattcc actggtcgct 2220361 atgggacgcg aaattctagt tgaccctaac tggacggtaa aagtaaaaga aggccgtgaa 2220421 aagcaaatcg aaacagtgat caaaggcaca gataaagaaa aatatcattt gcctgaaccg 2220481 ctatggcaag caattgtgaa cacacaaggc tgggtgcctt ataaagatta atgtgcaaag 2220541 actgccgaaa cgattcggca gtcttttttc cctttatata aatagtttgt gtacacatct 2220601 aaacagcaaa agaaagagct ccccaccaac ttcgaaaaga aaatccagga aaaacccctc 2220661 acgctttctt gcttttttct ttttcattcg tacgtctcct ttttacatga atacgcctta 2220721 cttacgattt tgcaggagaa aggtttcatt ttataacgga cacatctagg gtcgatcatg 2220781 cttcgtgatc ctataagatg tatgaatgga ccaagagtgc aggtaatacc gccatttgct 2220841 ttccttactt ttcaaaccta tcctttacta tatgcggata cttaatattc ttctcccata 2220901 ctacaaatgt ccccaaaaca aaacgcctcc tatttatcag cgcaaactaa taaataaaag 2220961 acgtttgatt taatgaccac ttaataagct catgtttaag aagccttatg ctctaacctc 2221021 agcttatccg caaccattgc aatgaattca ctgttggtag gtttagcttt tgtcatgctg 2221081 acagtataac caaacaacga ggaaatggaa tcaatgtttc ctctgctcca tgccacttca 2221141 attgcatggc ggatcgctct ttctacacgg cttgcggttg tgttaaattt tttggcgatg 2221201 tccggataga ggacttttgt aatgctgccg agcaattcga tgtcattgta taccattgag 2221261 attgcttcgc gcagatagag atagccttta atatgggctg ggacgccgat ttcatggata 2221321 atgcttgtga tgctcgcgtc gagatttttc ttctttggtt caggctggct gctgcgtata 2221381 atactgcttt gcgatgatgg cgcacgatgc gtcacactgc tggcatttcc gctgacctgg 2221441 cggatatggc cgacaaggtt ttccatatca aacggtttga gaataaagta ggacgcgcct 2221501 aaatcgacgg cctttttcgt gacatcttcc tgcccaaagg ctgtcagcat aatgacattc 2221561 ggctgttttt tcagatctga ttccctcagc ctctctaaaa ccgcaagtcc gtctagatgc 2221621 ggcataataa tatctaatac gagcacatcg ggatcttttt ctttaaacag cgacaggcat 2221681 tcctgtccgt tataagcaac gccgatcact tccatgtctt cctgtccttc tatatattca 2221741 cttaacaggc ttaccagctc tcgattatca tcagcaacac aaactttaat tttctccacg 2221801 tttcttcctc cccaaatgta gttaacagga ttcacccttg ctacatgttt acattcgaca 2221861 aaaccgctat ataccctcta aaaaaatcat aatcaccaat attagtggca tatctttgtt 2221921 attctatgtt tttctctgtt tttcgactaa aaatgaaatt tgacaaacaa ggaaacgtga 2221981 atttgtcgaa aaatcttctt ttgtatattt taccgtatgt attctgagaa gtgaagaggg 2222041 atcaaaataa aaaaactgcc ggaaactccg gcagtcagct tgctttttct tttccataaa 2222101 tatcgattcc tgcttctgac agcatccatt caatatgaac accgtagccg cttgtcgggt 2222161 catttacaaa tacatgggtg acagcaccga tcacttttcc attttgaatg atcgggcttc 2222221 cgctcatccc ctgtacgatg cctcctgttt ctttcaacag tcttggatcg gtaattttca 2222281 acaccattcc ttttgtcgca gggaattttt gcggcgttgt gctgacgatt tcaatatcga 2222341 atttttctac tttgtcatca tcaataaccg ttaaaatttc agccggccct tttttgactt 2222401 cggtagaaaa cgcaaccggc aatgcttgat ctgatatgtt gttttgaatc ggctgatgca 2222461 gtgtgccgaa aatcccaaac gggctgtttc tgttaatatc cccgatcgtt ttgcgttctg 2222521 aggaaaatcg cgccagtttt tctcccggat taccgcctgt ccctttttca attgatgtta 2222581 cagtggattt aacgatttct ccattctcca ctacaattgg tttctttgtg tccatatcgg 2222641 aaatcacgtg gccaagtgct ccgtattttt ttgttttcgg ttcataaaag gtcatagtgc 2222701 cgatgccagc agcagaatct ctgatatata acccgattct gtatttgcct tctccttcat 2222761 ccttttctgg gatcagcttc gttttgattt tctgtttatc acgtttgatc agtaagtcta 2222821 aagattcacc agttttccca gccttttgaa taaatggggc tacatcattc attttttcaa 2222881 ttttctgtcc attcatctca ataatgatgt cgcccgcttc aattcctgcc gtttctcccg 2222941 gagatttttt gccttcactt gtattgattt gatgaaatcc gacgacaaga acaccgacgg 2223001 aatgaagttt tacaccgatt gattgtccgc caggtataac ttttaaatca ggaagaacat 2223061 gcacttttgt ttttttaatt ggaaatccgg caagatcata taccaattct gactcacctg 2223121 attttttgcc cgtcaccttg atttcatgcg gatctttctt tactgtaaac gcttctgagg 2223181 attctgatgt ctgagcgttt accgataaac tcgtttcaat cgcttgtgtt tgggtttcaa 2223241 atactctcat ttgcgttgga atcagtaaat attcttttag cggtttgcat aaacctacac 2223301 ttaataacga aacaaggaga attaaaccta ctgcttttct gatgttatcg ggcattcact 2223361 acttcactct cctcgctcct atcccacacc ttctttatga cttgctgcta catcatttaa 2223421 ttttgccttc tgacggctta tttataactg tcatatgaag aaaaacattg gatatactga 2223481 tgaacgaatg gatgtgcacg aaaaaaataa gctgcgcttc tcgcgcagct tacccagttg 2223541 ttttgacttg atccgcttgt tttaaaagtt ctttcgcatg gcgtttcgtt aagtcggtta 2223601 cttcgacacc tgcaatcatg cgcccgattt ccgctacctt ttcctgctta gagagcggct 2223661 tgacacgtgt cgtcgttctg ccgtctttta actccttcgc aatataaaga tgcgtatcgg 2223721 ccatggcagc cacctgaggc aggtgtgtaa tgcacagcac ttgtgatcct attgacacct 2223781 tatggatctt ctcagcaatt gcctgtgcga ccctgccgct tacaccggta tcaacctcgt 2223841 caaaaatgat cgatgtcaca tcctgttgtg aggaaaaaat gctttttatg gcaagcatca 2223901 cccgtgacag ctctccacct gaagcgactt tcgaaaggga tttcagcggc tcgcctgtat 2223961 tggttgaaat taaaaacttc accaggtcaa tcccttgttc agtcagctga acgggctggc 2224021 cgtttacaag cggcgcctct tcattgcgtg acgctgttct gaccttaaat tccgtatcaa 2224081 aagttgattt ttccatgtac aggcttttta attcccgatg aatctcatca gccagctttt 2224141 tcgcccatgt ttttcggatt tgtgacacat ttgccgcttc cactgcgaca tctttgccga 2224201 cggagtcaag ctcctttttc aagctttgaa ggtggctgtc cctgttttca atttggtcaa 2224261 tctcttcttc aattttagaa gcatattcca aaatgtcttc aacagtggca ccgtattttc 2224321 gtttcagctg tttgatttca ttaagtcgcg tctcaatata gttcaggcgt tccggatcaa 2224381 attcaagctc atccagcata tttctcatct gaaatgtggc atcctcaagc aaatagtagg 2224441 agttcgaaac actttcagac atttttttca gcggttcgtt tatatcagat atatcttcaa 2224501 gctgcgctga tgccattcca acccagtcca atccgccctg ctcactgcga agcgcgttat 2224561 atgcattttg cagcgactca tatatcttct caaagtttga aatttgctgg cgctcttctt 2224621 ggagctgttc atcttcgtta agctcaagct ttgccgattc gatttcttcg agctgaaatt 2224681 gaataagatc aagacgatgg gccatttcct gttcgctttc agaaagctgc ttaagctttt 2224741 tgagcagctt cacataccgc tggtaccctt cctgatacgt tttgagcgcg ctttccactt 2224801 cggccccggc aaacttgtcc aaaagctgga gatgattttc gtcttccatt aacagctggt 2224861 tatcgtgctg cccgtgaata tctaataaaa gcctgccgat ctctcttagt gaagcaatcg 2224921 tgacaagctt gccattgaca cggcaaacgc ttttcccgct cgtgctgata tcccttctca 2224981 tgacgatcat ttcgtctgaa acgtcgattc cctgctcagc gcatacgcct aaaacaggat 2225041 ggccgctctc caacagaaac agcccttcaa gttcggcttt tgcttcccca tatctaacaa 2225101 attcagatga tccgcggcct ccgactaaaa gagaaatggc atctatgatg atggatttgc 2225161 cggctccggt ttctcctgtt aaaaccgtaa gcccgcgttc aaaagaaacc gtcagttcct 2225221 caataatggc aaagttttta atcgatagtt cagctaacaa acagcattac acctcttatc 2225281 tttgttagat tttctgttac agcagttcaa ggagcctgtt ttttacgcct tctgtatctt 2225341 caggagtccg gcaaataatt aaaatcgtat catctccgca aatggtcccc atcatttcat 2225401 cccagtccaa attgtccatc agcgccccga ttgcctgggc attgcccggc atcgttttca 2225461 gcacaatcat atggcttgct gagtctattt tcacaaatgc gtccatcaat gcccgcttta 2225521 gctttgacag cggattgaaa cgctggtccg ccggaagact gtatttgtaa gaaccattat 2225581 ttgtaggcac ttttacaagg tgaagttctt taatatcccg tgataccgtg gcctgcgtta 2225641 ctttgtatcc atcctgcttt agcatgtcga ccaattcatc ctgcgtttcg atttcattgc 2225701 ttgtaatgat ctctctgatt ttaatatgcc tctggccttt gttcatgtaa gcacctctat 2225761 ttccaagctt atctgttctt ttatgttata tgattctctg cacattgtac atgaatgcag 2225821 aaaaaaggaa taatagcgcc ctattattcc ggtacatctg cttttttttc ttttaacgtc 2225881 ttatgtgctt cttctacaac gcgcatgatc tcttcttccg gcagttcctg gccttcctgt 2225941 ccctctcccg gccaatgcaa atgaaggaga aactcaatat ttccgtctcc tcccgtgatt 2226001 ggagaaaatg acaagccttt acagatatag ccttcagcgg cagaaaaact gatcattcgc 2226061 ttgagcacat cagcatgcac tttaggatct ctaacaatcc cttttttgcc gacggattcc 2226121 cgtcccgctt caaactgagg cttaactaaa gccatgcagt cgctgcccgg tacgagcaaa 2226181 gtccttagga caggcaggat gagccgcagt gaaataaagg acacatcaat tgtggcaaac 2226241 tccggcatgc cctttgtaaa gtctgccggt gttgcataac gaaagttcgt ccgttccatc 2226301 acgacgaccc gttcatcctg tctaagcttc catgcaagct gattatagcc tacatccaca 2226361 gcgtatgact gtttagctcc attttgcaaa gcgcagtccg taaaaccgcc ggtggaggag 2226421 ccaatatcaa tcataatttt atctttgaca gagacgggaa attccttcaa cgctttttcg 2226481 agctttaagc cgcccctgct cacatacctc agcgggtttc ctttgacagt taacggaagg 2226541 tcgcggtcaa ttttttctcc aggcttgtcc aagcggtttt cgtttgaata gacgatcccc 2226601 gccataatgg ctcttttggc tttttcacgc gtttccgcca gccctctttc cactaataat 2226661 acatctaatc gttctttctt tgacgtcatg atccaattcc tttgtgtgtc tttggtggca 2226721 tcagtaatct aatacgattt gccacctgct gttttgtcag tccaatttcc tcaagaagcg 2226781 ctgttacact tccgtgttca ataaaccgat caggtatacc cattctgtca atcggagtat 2226841 gatattcacc ttgatcatga gcgaattcta aaatcgagct tccgaaaccg ccttctaaga 2226901 ccgcttcttc aattgttaaa attggcaagc cttcttttag gatactcttc atcatctttt 2226961 catcaatcgg cttaataaaa cgcgcattca caacgcgcac ggaaaggcct tctttctgca 2227021 gctcttcggc tgcttcaatc gccatttcga ttgttgtgcc gaatgttaag atgacagcat 2227081 cgttccctgg acgcagcacc tcccacgtac cgatcggaat cgttttcaac tgttcatcca 2227141 tttttacgcc gagtccgttt ccgcgcggaa aacgcattgc tatcgggcct tcgtcatagc 2227201 taagtgctgt atgaaccatg tgctggcctt cattttcgtc tttcggcatc attaagacca 2227261 tgtttggaat gtggcgcata aacgcaatat caaacacgcc ttgatgtgtc tctccatcag 2227321 cgccaacgag tccagcacgg tcaattccaa taaacacatt agcgttttgg cggcagatgt 2227381 catgaacaac ttggtcatat gccctttgca ggaaggttga gtaaatcgcc aaaaacggct 2227441 tcataccctg cattgccata gctgcagcca ttgttgcggc atgctgttct gcgattccta 2227501 cgtcgaacat ccggtcaggg aattcctttg cgaagccttc aagctttgaa ccgacaggca 2227561 tagccggcgt aatggctaca atgcgtccgt cctcgcgcgc cattcgctgc acagttccgc 2227621 tgacaagacc gctccacgaa ggagctgcgg ctttcggctt tacaaagtca ccggtattaa 2227681 ttttatatgg tccggtacca tgccatgtcc caatcgtatc ggtctcagcc ggtttgtacc 2227741 ccttcccttt tttcgtaatg acgtgcagaa gaacagggcc tttcgttttt ttggcgtatt 2227801 gaagattctc aatcagctca tgataagaat gtccgtccac tgggcccaaa tacgtaaaac 2227861 cgagctcctc gaaaaacatt ccggagacga gcatgtattt caggctgtct ttgacccgtt 2227921 ccgccgtggc ggcaagcttg cccccaactg ccggaatctt tttaaataag tattcaagct 2227981 catctttgac ccactggtat ttccccgcag tgcggagccg tccgagcata gagtgaatgg 2228041 caccgacgtt tggcgcaata ctcatttcat tatcattaag gatgacaatc atgtcttttt 2228101 tctcgtcgcc gatgtggtta agggcttcga gcgccatacc gccggtcagc gcgccgtcac 2228161 caatgatcgg aataatatat tcatccgttc ctttaatatc acgggcagct gccattccca 2228221 tcgcgcctga cagagaagtc gagctgtgcc cggtttccca aacatcgtgc tcgctttcac 2228281 tccgctttgg aaatccgcaa agccctttgt actggcgaag cgtcgcaaat tcttttccgc 2228341 gtcctgtcag cagcttatgg acatacgact gatggcctac atcccataaa aatttgtctt 2228401 tcgggctgtt aaattcctta tgcagggcaa cagtaagctc tacgacacct aagtttgggc 2228461 cgatgtggcc gccggaagcg gataaacttg taattaaaaa ctgacggatt tcatcactta 2228521 atttctctaa ttcatcaatg gacatgtttt ttaaaaacga cgggtcctgt attgataaaa 2228581 gatccaaagc ggatcaactc actttcagca tgaatttctg caatgataca tgtcttttgc 2228641 atgccgagct gacaataatc tcagacataa aaaaagacaa acgcgctttt ccttttcatt 2228701 tttcatataa actgcttaca ttttaccata cctcgtgcag ccgcttcaaa ttaggatcgt 2228761 tttagtgatc tcttgccgca attaaatcac aaagctcata taaaaggtct ttttgaagag 2228821 agagtccgcc gatcaatcgc ttcgcctctt ttatatgaac atccaattta tgtttggccc 2228881 cttccaatga aagaagcgac gggtatgtcg atttgtcatt tgtggtatcc gagccgacac 2228941 gtttgccgat tttctcttca ctgccttcta aatctaaaat atcgtctctg atttgaaatc 2229001 cgattccaat gtggctgctg aaggtacgca gtgtttcaat gtcttcctca ggcgcatcag 2229061 ccaaaatagc accggcgatt acacaaaagc caaggagctt ggcagttttc cgttcatgaa 2229121 tggattcgag ctcttcaagc gtgacttgtc ggttttccgc ttccatatca gctacttgcc 2229181 caccgaccat gccttcggtg cctgccgctg aaatcagttc attcacaagc cgcaggcgct 2229241 tttctgctga cacctcgtct gacacgtggg aggtaatcag cttaaagctt tctgtgagca 2229301 gcccgtcacc cgctaatact gccgtcgctt caccaaacac tttatggttt gtcggcttcc 2229361 cgcggcgcaa atcgtcatca tccatgcatg gaagatcatc atgaattaac gaatacgtgt 2229421 gaatcatttc gacagcacag cccaccggaa tgccgtcttt ttcgcttttt ccatatgcat 2229481 ttaaaacagc cagtacaatc agaggccgca accgctttcc gccggcctgt agagaatata 2229541 gcatagattt ctttaatgag tccggcatat caagcttttc tgtatagaca gaaagctgat 2229601 tttcaattgt ttttttccgg tccgccagaa agctcgttaa tttatttgtc accttcgtct 2229661 tcctcctgaa cactgaaagg tgccagttcg ccgtcttctt ttaaaatgaa gtccatttgc 2229721 ttttcgactt tttgcagctt ttcatggcac atttttgaca gagccatgcc ttcttggaaa 2229781 tagttaatgg cttgctctag aggcacatct ccctcttcaa gctttgatac aatgctctca 2229841 agccctttca tcgcttcttc aaatgtcatg ttttcatttt ttttcacgtc tgtcattttt 2229901 cttcccctct cttttctaat acttcacagg tcagcacgcc atccttcagc ttgatttcaa 2229961 gccggtcctg ctcttctatt tgactgacac ttttaatgag tttatcttct ttataagcca 2230021 agctgtatcc tctttccatc acttgaagag gacttagtgc attcagcttg ccaagaacgg 2230081 tttgaaattg ggaatgcagc tgcttcattt ggatattcat attttttctc agctgatttg 2230141 tttgttcctg gtatcgtgtt ctcgcttgtt tcagctgttc atgaggatgc aatgcctcta 2230201 atctgtacgt ttcacgctcc agctgtctgc ttttccgatc taaaagagcg gtcagctgtg 2230261 cttgaaactg ctggtacgcg aggtcaaact gctgctcttt ttgcgcatac aaacgctttg 2230321 gaaaacgaaa ggcataggac gattgcagcg tttgtatccg ttcttttttc tggccgagat 2230381 gctgctgcat tgctcttgtc attctgactt ccgctgtttt tgtccgttcg attaaatcag 2230441 tggtatgagg cacagcaatc tcagctgctc ctgtcggcgt cgcagctctg atatcggcga 2230501 caaaatcact aatcgtaaaa tccgtctcat gtccgactgc cgatataatc ggaatattgg 2230561 aagcaaagat ggcgcgtgct acaatttctt cattgaatgc ccacagttct tctatcgaac 2230621 cgccgcctct cccgacaatt aatacgtcgc aaatctcttt ttcatttgcc tcttcaatgc 2230681 gcgtaacgat ggatctgctc gcattttcac cttgtacgag cgctggaaga acaatgactt 2230741 ttacaagggg atatcttctt tttagagttg taataacgtc tctgacagcg gcacccgttg 2230801 gagatgtcac aaccccgatt gtggctggaa atgcggggat ttgttttttg tagcggtcgt 2230861 caaataaacc ttctccggca agcttctttt ttaattcttc gtacgctaaa taaagcgctc 2230921 caaccccgtc aggctgcatt tctttggcat ataattgata gtttccgctc ggttcatata 2230981 cggaaattcc gcctctgacc agcactttca ttccgttttc aggtttaaaa ggcagacgct 2231041 cgctttgtct cgcgaacatc accgactgca ttcttgcgtt ttcgtctttt aaagtgaaat 2231101 aaatatgccc tcgtgtgtgt atctttacat tcgacaattc gcctttaatc caaatatttt 2231161 caaggtgagg atctacatcg aattttcgtt ttatatactt tgtcagcgct gagacggtca 2231221 catacgctgc ttcacccatg tctaaaaact cctctcctaa gcattcctgc accataacta 2231281 aagaaaaccc gccctggctt taggagcctg aagaagcggg tatcgtgctc atattcaagg 2231341 cgggtaaaca tttcgcctgt gaatatctcc aattatctat gataacgtac gtttcgcaga 2231401 tttaacagta ttatgcgcaa gcatcgtgat ggtcatcgga cctactccgc ccggaaccgg 2231461 cgttatgaag gacgcttttt cctttgcccc ttcaaattca acgtctccgc aaagctttcc 2231521 gttttccaga cggttaacgc cgacgtcaat gacaacagcg ccctctttga tctggtctgc 2231581 actgatgaag ttggctctgc cgactgccac caccaggatg tccgcttttt tcgtatgttc 2231641 agtaatattt tctgttcttg aatgacagta agtaaccgtc gcgttttcat ttaataaaag 2231701 ctggccgaca ggtttgccga caatgttgct tcggccgact acaacaacct ctttaccgga 2231761 aaggtcaata ttggttttct tcaaaagctc aacaattcca tgaggcgtgc aaggaagaaa 2231821 cgtatcttcg ccaagcagca ttttccctac gtttaacgga tgaaaaccgt ctacatcttt 2231881 atcaggggag atacgttcga tcaccgcttt ttcagaaata tggtctggga gcggaagctg 2231941 aacgagaatg ccatgaaact cagggtcttg gttatattga tcaataatgg aaagcagttc 2232001 agcttctgtg aggctgctgt caaattgatc gagcttgaaa ttcattccca ttgtttctgc 2232061 cgcttttttc tttcctcgca cgtaagagtg agaagcagga tcatctccaa tcaaaataac 2232121 cgccagtccg ggagtgacgc cttgcttttt aagctcttct acctcttttg ccaattgttc 2232181 gcgtttttct ctagccgttt cttttccgtc gatgattgtt gcagtcattt tctttcctcc 2232241 tatgattgtt caatatcaga tttaatgtta gaaagaaccc cgtttacaaa ctttgtcgct 2232301 ttgtcatcac caaaccgttt tgccagctca atcgcttcgt tcatggagac attcaccgga 2232361 atgtcttcgg catatgccat ttcatatgct gccaggcgca aaatcgcacg gtcaacattg 2232421 gcaatccgat cgagcttcca attcaccaga tgcttggaga tcatttcatc cagctggtct 2232481 tggtgttcca ataccccgtg tacaagctgt tcaaagaaag gatctgtttt ttcttcatcc 2232541 agtgcgtgtt ctatggcttc attcactgca atatcgctga catcaatttg aaatagtgcc 2232601 tgcaaagctt tttctcttgc tgttcttctt ttcattttct ttctcctttg atcctcttta 2232661 tccgcttgtc gttaagccac aaagagatca taacatattt ttttcgtatc cgcatattga 2232721 aatcaaggtt tttttaccct attaccgaat attttcacac accttaatat gattattcgg 2232781 atttcacgtt catgaagaaa ctcggctatg taagccggct ttcttcatgc tttgaaataa 2232841 agggtaacgt gtaaaaaaac caaagggccg ccctcccctt ggtttcgtgt taagccattt 2232901 acatttcttc gtcgatttgg acttcttggg cttttgtgtc aaattgaatg ccgacgatgt 2232961 gaatattgat ctcgttaatc gaaagagacg tcatatttaa taaggtttga cgaatgtttt 2233021 cctgaacgga tgctgcaact ttcggaatcg aaacgccaaa tgtaacgaca cagtatacat 2233081 cgatcgtaat tccgtcatcc gccaggtcga ctttgacacc tttgccatga ttcactttgc 2233141 caaagcgctc aacgacgcct gtcgcaaagt ttccgcgcat ttcggcaact ccatcaactt 2233201 ctgatgctgc aatgccggca atgacctcaa tgacctccgg tgcaatctca accttaccca 2233261 aatgcgtatc ttcgtgatcc attttaagca agctgttgtc tttcattcaa ttcacctccg 2233321 taaaaattat gagcccatta catcatatgt ttctaaaaat ttcgtattaa actctccgct 2233381 cacaaatgtt tcgtgttcaa gcagttttaa atggaaaggg attgttgtct caatgccttc 2233441 gatgacgaat tcgctcaatg cgcgcttcat gcgggcaatc gcttcatctc tcgtttttcc 2233501 gtatgtgatt acctttgcaa tcatgctgtc atagtacggt gggatggaat agccagggta 2233561 cgcagctgaa tcgacacgga caccaagacc gccaggaggc aggtacattt taatttcacc 2233621 aggtgacggc atgaaatttt tgcttgggtt ttctgcgttg attcggcatt cgatggccca 2233681 gccttcaaat tcaacatctt cttgcttgag gctcagttcc attcctgaag ccactttgat 2233741 ttgttccttg atcaggtcag ttcccgtcac catttctgtg actgggtgct ccacctggat 2233801 tctcgtgttc atttccatga agtaatagcg ctgttcattg tagtcataga taaattcaac 2233861 tgttccagca cctgtatagc caaccgcttt ggcagccttt accgctgcat ctcccatttg 2233921 ctccctgatt tctgaatcaa gggcaggaga tggtgattct tccaaaagct tttgcaggcg 2233981 tctttggatc gagcagtcgc gttcgcccaa atggatcgta tttccgtagt tatcagcaag 2234041 cacttggatc tcaacgtggc gaaaatcttc tatgtatttt tcgatgtata cacctggatt 2234101 cccaaatgca gttgccgctt cctgctgtgt aatcttaatg ccattaatca gttcctcttc 2234161 agtgcgggca accctaattc cttttccgcc tccgcctgcg gtggctttta taattacagg 2234221 atacccaatt tcattagcaa gcgaaaccgc ttcttccaca ttttctataa ttccctgtga 2234281 acccggtacg attggcacgc cggcctgttt catcgtttcc cgcgcaacgt cttttgttcc 2234341 catttttgaa atggcgtcag cgctcgggcc gacaaacgtg acattcactt cttcacataa 2234401 ttcagcgaaa tcagcatttt cagctaaaaa tccgtatccc ggatgaatgg cgtccgtgcc 2234461 agtcagcttt gcaacactca caatatttgt aacgtttaaa tagctgtctt ttgatgcttt 2234521 cggtccgata caaaaagctt catcggccat ttgaacatga agggcatctt tatcagcttc 2234581 tgaataaaca gcgacagtct caattccgag ctctctgcag gctctgatga ttctgacagc 2234641 aatttctcct ctgttggcga tcaatagctt tttaatcatg ttcagtctcc ttactccgct 2234701 tttacaagaa atagaggttg tccgtattcg accagctggc cgttttctac taatacttca 2234761 acgatttcgc ctttcacttc tgcttcgatt tcgttgaaaa gcttcatcgc ttctacaatg 2234821 cagacaactg tgttttcatt tacttttgaa ccggctgtta catacgggcc agcttccggt 2234881 gatgaagaag cataaaatgt tcctaccatt ggtgaagtga ttttatgcag attctcatct 2234941 tgctttggtg cttcttgggc aggtgccgct gcttgctgcg cttgcggctg aactgcctgc 2235001 ggagcctgtg cttgtacagg tgctgccggt gcctgctgca tgacttgaac cgtgcctgct 2235061 tcgtgttttt tcagttttaa ggatacacct tcattttcat atacgaattc gtcaattgta 2235121 gactcgtcaa ttgctttaat cagctcgtgg atttctttga tatttaacat tcaatcgcac 2235181 tcctatgtat gaaatttctt tttttatagg ttactactaa aagtacatac tatgttcatc 2235241 ttacaggagc ggacttttga attcaactct aatatgacag caacgcaaaa agcccgcttg 2235301 tttagcgggc ttttttccct cattcttatt tagagggttc aaatgtgaca gcgacatctt 2235361 tcattgtttt gatttctttt gccacaaggt ctataatggc tgtcgccttc gatttagagt 2235421 gtttgtctga tttgactgta atattgattt tatctccttc agcattaaca agcgcatcct 2235481 cgtaaccttg tgttttaatc agcgtttcca gctgtttttc tgttccttcc acttcactga 2235541 gagccgtcat tttatcgtat gcttcgcttt tctccttggc tgttgcatca tcgcttgaca 2235601 caatggcatt cagctcttct ctttctttgc ttctggcatc ttctaaatca agacggtacg 2235661 ttgtaaacaa atcatcatcg gctgtttccg taacaacagt tcctttttca ctggcttcag 2235721 cggatgtttc cttgtctgct gatgaatctt tcgttccctt tgttccatct tcttttcctt 2235781 tttcagtttc tgtaccgctt ttttccttcg tgtcttgctt ggcaggcgct ttttcagttg 2235841 cgacctctcc gctgtcagac gcgctttttt cactttgcat ctgcacggcg tttttgcttt 2235901 ccggcgacat gatatagtag acgcttaaca ccacgacaag actgagcatt gttaatagcc 2235961 aaacggtttg ttttttaagc atttatgaat cctcctttat ttttttaggg gcaaccgcaa 2236021 cccggtggct tggaacatcc aggacccgtg tcaccgcttc gataatggtt tgttttattt 2236081 gaacgttgtc cactccttga gcaacaacga gtacaccgcg tatatcaggt tttttcgttt 2236141 ggacgacgac aggtgtttct ttatcgccgt ttttgatcat gacgatttct tcctccgatg 2236201 attggtctgt aacgcttctt tttccgcctt ctttgtcagt ttcttcagtg gttgtatttt 2236261 tgtttgattt gtttttttcg tatactttca gcgacgttgc atctacattc acgacaaccg 2236321 agacatcgtc cacaccaatg attgtttcaa gaatttcttt cagttgattt tcgtattctt 2236381 tttcatagtc atcgatcgag tctttaggtt tatcagattt tgaggcttta aacacttcgg 2236441 ctgttttctc tttgctgtct gcggaatgtt gtgatgatac ggccgttatc gttttggcgt 2236501 tttcagtttt ctcaggtgaa gaaaacagct ggctgacaag cataaaggaa actccgagaa 2236561 caaaaacgaa tagaaagtaa tgatatttgg tcagcttcgg cttttcgccg tccttcgttt 2236621 gtcccggaag aaactgcttt ttcaatacat tccataatcc gtttttattc attgccgaca 2236681 ctctccccgc cttccatatg aaccgtaatt ttctcacttc cgatttccca aatgtccgcg 2236741 agctgcgttt gtatctgttt ggcttctttt tgttcggctg cttcttttgt tacgtatgca 2236801 tgatctgtat caatgtggac cggcgcgacc gtttggaccg ttttttcaga agacggggcc 2236861 atatacacgc tgattgtttt aatatcctct tctgaatcta ccttttctcc tgccgtgagt 2236921 ttgatgcggc ctactttata ttcatcatga ctgaatctct cctccgcttt cttttttagt 2236981 tggacagcca tttcttctag aatatatgcg cgctgggaag cttgtatttc tatttttttt 2237041 gaattgattt gattttttat gtcggcagac tctgactgcc cgttttttgt gaggtattca 2237101 aagatgactt cggggtctgt cttgaaaagt ttaaaaatcg gcgtaagcat gacgacaatc 2237161 aagagcaggc tgactaccat ttttgcgtac ttttgcatgc tggagctcgg cagcagcata 2237221 tcaatcacaa ttgcaaatag gataaacaac acgatggtgg taagccattc cgttaaaaaa 2237281 ctcatttgcc tgcctccttc atttcatcat catcgtgagg tttccggctg tgattatgac 2237341 agtaaggctt aaaaaaaaca tgagagacac aatggcgaga gctgcaaaaa tataaatgac 2237401 gcttttgctg atgacgtcga ggcaggtgat gacgggcccg cctcctagcg gctgaagaat 2237461 cgcggctgcc agcttataaa taaaagcgag ggaaagcact ttgattgccg gaaatgccgc 2237521 aatacagatc aaaatagcga caccgagaat ccctaccgta tttttcagca gtaaagaggc 2237581 gctgattact gtatctgttg cgtctgtaaa cattcggcca agcacaggaa taaaatttcc 2237641 ggttataaat ttagccgtcc tgagcgtaat gccgtctgtc actgcagctg acgctccctg 2237701 aacagagatg acgccgagaa agatggtaag aaaaacagcc agtgctccga tggcgatatt 2237761 tctgagcagg ttagccagct gcgttacttt gtattgttca gtcatcgtgc tgacaatgct 2237821 cagaatcgct gataaaaaaa tcagcggcat gacgatattc tgaatcaaga gaccgctcgt 2237881 gttcatcagg aagaggataa caggatgaaa gaaggcagca gatacagctc cgcctgagga 2237941 agccaaaagc gccaagagga gcggaatgag cgccaggata aagctggtca tcgtctgaat 2238001 cgcctcagtt gcatagttaa ttgccacatg aaagctatta agcgcaagga taatcagcac 2238061 catgtacaca attgagtaag cgaccttact gacggtgctt tgctgaaaag cattttgcaa 2238121 aagctgcaga atgacgcaaa aaatcgtgag caaaatcaat gtgcccagca gctttccgtt 2238181 ggcaagcact tcatgaaaca aataagaaaa gagagctttc agccattctt gcggtgagaa 2238241 tgatttatcg ccattgataa actccattaa gctgcctttt tggctttccg gcagcagtcc 2238301 gccgtattct gtcataatgt cattccaaaa ttccccgatc ttatctgttt caagcgaggc 2238361 tgctgtcctt tccgctaatt gctcggctgt ttcagcatgg tcttccgttt gttctgcatt 2238421 accagctgct tgtacaattt ctgcacggcc tgctatgatc agcacggcca aaagcaaaac 2238481 ccattgaaag cgcttcaatc taccgcctcc tttcggttat gacatagaag gtataagtcc 2238541 gagaatcgtt tcgataatga cggttaaaat aggcacagcc attacgagta ttaaaatttt 2238601 ccccgccaat tctattttcg aggcgatggc tccttgaccg gcatcttttg tgagctgtgc 2238661 cccgaattca gcaatatagg cgattccgat aatctttaaa atggtttcaa catagaccat 2238721 gttgacattt gcattaatcg caattttttc tatcattcga ataatgtcgt agatttggtc 2238781 taccaaataa agaaaaatgg cacatccggc aaaaacgacg attaaaaacg caaaagtcgg 2238841 cttttgttct tttacaatta aagaaaggaa ggtggcgatc agccctaaac ctacaatttg 2238901 aacaatgtca atctgcaagc ccccctatcc ttggaataaa aacacagctt ttatcttttt 2238961 aaataggtca tctacaatcg tggcgaccat aaataaaata tagataaaac ctaacagcgt 2239021 cacccactga gcatattctt tcttgcccat ctgatccaat atcgtgtgta aaaaagcgac 2239081 cacgattccc actccggcga tttgaaatat gacattcacg tctactccca ttttattttt 2239141 gctcccctca cgtttacatc aatagaagaa tgagtaacaa gcccgctaaa aagcccaaac 2239201 tttttatcat cttttcgttt ttcgcttgcg cctgctcagc atccgcttct gaggcttcca 2239261 aatgtgtcag cgccagcttg atgtgctttt gctgagagat tcgatcatga atcccaagcg 2239321 tctcgccaaa ctgcttcagc acttcgtatt cgcttttttt caaagacagg gtgtcccata 2239381 ccttctttaa gctttgctcc cacgccgttt tcgcggaatc acttcccttg tccagctgat 2239441 cactgaatgc ggaaaaaaga gttgaaacag gctgtgcgag ctgtttggca atctgctgtg 2239501 aagcagtatg aagcggtgta tggccgtaca tgatttcagc ctcgagggat tgaagcgccg 2239561 cacgcagctg gcggatttgc cgcggccgtt ctgtataaat cttcgccatc tcaaaacctg 2239621 tccatgttgt cgctaccaca atgaatacag cgcccagcag cttcagcatg ttttcacgcc 2239681 cgtcgtccta gacagcacat ttccgtcttt gtcataaatt tggctcactg tgcccggccc 2239741 ttttgctctt gataattcca aatagcggtc aaaggctctt tcttcccaca aacgcttcaa 2239801 tgaaggccgc ttcatcaggt cggatatact ccagccatgc gccgatacga ttactgaaac 2239861 accggcatgc agcgcctcca gaagtgcatc tgtatcttcc atacgcccga tttcatcgac 2239921 aatcatcacc tcagggctca tggatcgaat catcatcatc agcccttcag cttttggaca 2239981 ggcgtctaac acgtcaattc tctgaccaaa ttgatgctgc ggaataccgc gaagacatcc 2240041 ggcaatctct gaccgttcat cgacgatccc tgtctttacg ggcagcatgt tttttttgcc 2240101 ggtgcttgag agcctcgcaa ggtcccggag aagtgttgtt ttgccggttt ggggcggtcc 2240161 gataatcagc gtattcagcc agctgttttg atataagtat ggaagcagcg gctccgcaat 2240221 ccccagcttt tgccgggcaa ttcgtatatt aaaagatgcg atgtcacgga ggcctttcac 2240281 acctccgttt tccgtaatga ctctgcccgc cagtccgact ctgtggccgc ctctgatcgt 2240341 gacataccct ttcttcagct cttcttcaag tgtatacata ctatagttgc tgagccggct 2240401 caggatcaga tgggcatcct cggccgtgcc cgcataggac aaataaacag gttgtcctct 2240461 tcgaatcaat tcaacagggc ggttgatccg aattctgact tcttcgattt ccagccattg 2240521 ttgttccggt atttcagaaa gggcgttttt catggattca gggagaacct cagcgatttc 2240581 attcaacaga gcctcctcct ttctaccgat tggcttcttt aaaatgtatg atgtgaggca 2240641 gactttatga caagcctctc tttatttatg aacacccgcc aaaatcaaga caacacccgt 2240701 aaaaatcaga atcagctttg catacgaaag ctgcccggca atttggtaga ttccgacagt 2240761 cattgtaatg ataaaaatca acggaccgac aatagcgaga atgctgttaa ccacaaccgc 2240821 cttccggaca tcgttggtca caagcatgac aattgctgcc gtcagctcaa tcatagagga 2240881 taaaactcgt aatcccgcca ttgttaaaac agtagaattg atatttccaa gtaaaaattt 2240941 catagcactc tcccaacctc ccattttttt atatgatatg ctctagcttg ctgaagtagt 2241001 cttgtcattt tcgtataaaa gaaagattct gtttttgggc acaaaaaaag cctgctccca 2241061 tttgggaaca gacttctttt tttctttcta tgctcttgaa acgtaagaac cgtctgatgt 2241121 attgacaaca agtgtgtcgc cttcattcac aaagaacggc acgtttacaa caagcccggt 2241181 ttcagttttc gcaggttttg taccgcctga cgctgtatca cctttaatac caggttcagt 2241241 ttcaacaact ttcagctcaa ctgtgtttgg aagttcgata ccaagtgttt catcctggta 2241301 catcatgata tgcacagaca tgttttctag caggtatttt aattcttctt cgatttgagt 2241361 tgcgctcagt tcaagctgct cataagaaga agtatccata aatacgtgct gatctccgtt 2241421 tgcatataga tattgcattg ttttggtttc gatttgcgct ttcgctactt tttcaccagc 2241481 gcggaatgtt ttttcctgaa tcgcgccagt gcgaaggttg cggagtttag agcggacaaa 2241541 tgccgcacct tttccaggtt ttacgtgctg gaagtcaacg acgcgccaaa tgccgccatc 2241601 tacttcaatt gttaatcctg tacggaaatc gttaactgaa atcatgttta atgtcctcct 2241661 atattccaat cacaaaataa taagttcttt tggggaatgg gtgattgtcc ggttgccgtt 2241721 ttctgtaatc acgatgtcat cttcaatgcg gacaccgcct gtttctggta tgtaaatgcc 2241781 cggctccact gtgaccacca tacccggttc aaggatagct gaagatctga cggataatcc 2241841 cggcgattca tgaacttcca tgccgagccc gtgcccggtt gaatggccga aatagtcacc 2241901 gtagcctttt gcagcaatat gatcccttgt gagggcgtca gcctcttttc ctgtcattcc 2241961 cggcttaata tgtgcgacgc caagcgcctg agcatcaaat acaacctgat agatctcctt 2242021 caattgatca ctgggctgac ctacagcgac cgtccgggta atatcagaac aatatccttt 2242081 ataataagcg ccaaaatcaa gcgtaacaag gtctccgctt tcaatcagtt tgtcactggc 2242141 cacaccgtgc ggaaggcttg aacgaaggcc tgaggcgaca atcatatcaa aagaagagct 2242201 gtctgctccc tggcttctca tataaaactc cagctcattg gcaacagcga tttcagaaat 2242261 gccgggtttc ataaacgtca agatatgtct gaaggcatca tctgcaatct tcgcagcttc 2242321 ctctaatatc ttaatctctt cactagactt aatcaagcgc aacttttcca cggattcagc 2242381 cacaggcact aattcggcat cactgataac ggcgctgtat gaagcgtaag tgccatatgt 2242441 catgctgttc tgttcaaagc cgagacgctt gatgccaaac gattcaacag tgtcggcagt 2242501 ggtctgaatc aagctgccgc catgttcaat gatctcaaaa ccctttacct gaaccttcgc 2242561 ctgctcagta taacgaaaat ccgtaataaa cgctgctttg tcacccgata taacagccaa 2242621 acccgccgaa cctgtaaacc ctgtcatata gcgtacatta gtgttgcttg taatcagcat 2242681 gccgtcaatt cccagctgtc caaacaggtt tcttaatttc tctagcttca tcttgattct 2242741 cccccttgct ggcttaataa gtagcgaaca gcaagcttgt agccttcagc tccaagaccg 2242801 acaatctgcc ctttcgcaac aggagcgata accgactgat gcctgaattc ttccctggcg 2242861 tataagtttg ataaatgcac ctctaccaca ggaagactga tgcttgaaac agcatccctg 2242921 atcgcatagc tgtaatgact cagggcgccg gggttcagaa caatcccgct gtattgctcc 2242981 tcagcctcat gtatcgcatc tatcaaatca ccttcgtgat tagactggaa gaaagtgagc 2243041 tggatatgta aggcttcagc aaactgaaaa agatctgttt caatatcggt cagtgtctgg 2243101 cggccgaata cttcaggctc acgactccca agccggttaa cattcggtcc gttcaaaatc 2243161 aaaaaatgag gcacacaatc tctccttttc gcgagggttt ctcatgtaaa aaatgttcac 2243221 ttctcgtgaa cattttatca tactggaaaa ggattataca ctattctcta tgcattccca 2243281 gcgcacgtgc aagcttttcc gaattcagct cattgtattc aaatgaaata gaatacccga 2243341 caaacagccc gtaaagcaaa taaatgcaaa tggtcgtaat aattgtatct gatgtcagtt 2243401 cggtcaccgt gcgcacatct ggaaaaatcg gattaaaaac aaaaaacacg agcagccaaa 2243461 gcaccaagcc gtataaaata cccggccaca ttgtttttaa acgtttcaat agaagaaaat 2243521 aaagaaatgc tgcgccaatt gaaattactc caatcaaaat gatgctgatt accgttccca 2243581 gcccatgttt tttccactct ccgagtacaa acggctgcaa tatcatattc gggctgattt 2243641 cggaaaaatg aaacaaatat gcgatataag caacgaaact ccaaagtacg cctccgcaaa 2243701 aacctgttgc cgccaccctg ccggccattg aaacaggcgg cttttgcttc tcattcaatt 2243761 cttcattttg ttctgtatct ttttcgcttg tcatcatggc acctccagtt aaagtgtgcc 2243821 caaaaaatga aatgtcaata aaaaagctca cactttttgg cagctgcgag taaaatttga 2243881 aaataacggg tataatgcat gtagaaaaag caaggctatg gcaatttttt cagcctgtca 2243941 atctagaggt ttagcgctgt ttcctgtaca atagagtgaa aggaaatggt tagcaatcct 2244001 aaagaaatag gcaggttgat aatatgtcaa aacataaagt tccgcccgct tacggcgggc 2244061 aggctgttgt ggaaggcgtt atgtttggcg gaaagcatca ttacgttaca gccatcagaa 2244121 gaacggatgg aagcattgac ttttttaagc ttccacgcaa acacaacccg aaactgaaca 2244181 tcgtgaaaaa gataccgttt ttacggggga tcgcggccat tatcgaagcg agtgcaaacg 2244241 gcacaaagca tttgaatttt tcaagcgaac gttacgggct cgatccatct gaagacgaga 2244301 cacttgagca ggaagaaaaa aaatcctctg ggctgtctat gtatctcagc ctcgcagtta 2244361 taggcgtcct atcatttttg ttcagtaaat tcgtatttac attggttcca gttttcttag 2244421 cggaactgac aaggccgatt ttttccttga acacagcgca aatcgcgatt gaaagcctgt 2244481 ttaagttgat tttgctgctc ggttacatct attttttgtc catgacaccg cttattaaaa 2244541 gagtgtttca atatcatgga gccgaacata aagtcataaa ctgttatgaa cagaatttgc 2244601 caattactgt ggagaatgtc caaaaccaat ctcggcttca ttaccgctgc ggatcaagct 2244661 ttattttatt tacgattatt gtcggcatgt ttgtttattt actcgttccg acagatccgc 2244721 tttggctgcg tgttatagat cgtgtcgcac tgataccggt cgtgcttggt atatcctttg 2244781 aagttctgca gctgacaaac aaagtgcgtg acattcccgg tctgaaatta cttgggtacc 2244841 cgggactttg gcttcagctg ttaaccacaa aggaacctaa ggatgaacag gttgaagttg 2244901 ccatcgaaag ctttaacgaa cttctcagac tcgaagcatt gtctgagcaa aatcagaagc 2244961 cttctcacaa cgtcatctaa aatccgttgc cctgctatta ctttcggagg tggacagtta 2245021 tgaatcatcg tgtacaacct attattgctg tattaattgc gctgggagcg ttcggtttcc 2245081 tctatgtgct ggtaaccaat cccggagaaa tggcaaaaat ggcggtaacc gtcatcgtgg 2245141 caggtatcat tatttatttt attgtgaaat atgtaatgaa tcgaaatgcg ggcagcgaag 2245201 gagcagcctt caaaaaagcg gcgaaacaat cacggcgccg gatgaaagaa caaaaagcaa 2245261 aacaccgcgc cggacataag ggacgtgtca gccacctgcg aagcgttccg agcgccagca 2245321 agcctaagcc gatgattctc aagaaaaaaa gccagactca gctgactgtt atagaaggga 2245381 aaaaaaataa aaagaaaaac agagcgcttt tttaataggt ccactgcttt aaaaacagct 2245441 ctgtccgtct tttacctagc tcaatcaggg ctagtttttt ttgttgtgtt aaatgaaaat 2245501 cagtggccat tacgtcatca acagggagaa aaatgatatt ttgttcatag cgtgacgcaa 2245561 tgtgccttgc gtcatgagca tccttcatcg tttcaaacag ggcgccgaac agttcaaaag 2245621 cgttgcggat attttttttc ggacgctctc tttcacgcgg cgcaagcgtg acaccgatca 2245681 cagggcgctt tctttccttt gaaaacagcc agattggaaa attgcttaac acgcctccgt 2245741 cgacaaccgt ggcggtgcct gtgtccgttt ttaattttat cggttcaaag aaatacggaa 2245801 tgctgcagct cattctgacc gctctggcaa ccgggaacat atctggattt aacccgtaac 2245861 gggccaaatc gtccggcaaa acaatcatgg tgccgtttgt cagatcagaa gcaataaggc 2245921 gcagagaccc tttctgcaaa tcgccgaaaa cccttatgcc tttcgctctt aacagatcag 2245981 caatccattt ttctatcgta tcgcctttgt ataagccaag acgccagtag atggacaccc 2246041 actggagcat ctttaagggg agaaatgagt acctctgatc cagcaatttc tctccgtcca 2246101 cttcttcaat taaagcgtgg atttccttac tggtgtaacc tgacgcaatg aaagcggcaa 2246161 taatggcgcc ggcgcttgta cccgcaactc ttttaaagcg gaagcctttt tcctcaagca 2246221 cttcataagc gcctgcgagc gcaatgcctt ttactcctcc gccggaaaac acaccgtcaa 2246281 tatacatctc attccctccc cctccatccg atcgtttatt accattttaa gaaaacacgc 2246341 gaagaaatag accaacgaat gacgggtggc gtcagcgtat caaaaaagac ggcctccttc 2246401 gagaccgcct ttttactgat tatgatgttc tgttttcttt tggattgatt tcagatcttt 2246461 tttacgggca tcatcttctt caaaatattg aacaagatcc ccgatgcgat caatactgtt 2246521 ccagcttaaa tgatgttcga ttccttcgac atcgttatat attttctctt catcaacacc 2246581 aatgattctt aaaaactgct caagcaattc atgtctgtat accagccgtt tgcctatttt 2246641 tttcccttta gacgttaaca cgagaccgcg atatttttca taaattaaat attcgtcttt 2246701 atctagtttt tgaaccattt ttgttacaga ggagggatgg actgccaatg cttccgcgat 2246761 atcggaaact cgtgcatatc ctttttcttc aatcagcata taaatctgtt caatataatc 2246821 ttccatactt ggtgttgtca tcgaaaccct cccaaaaagc accttaactt tataaaccat 2246881 tacaagttta cactaatgaa cttgaaaaaa caaggatgct ccgcgggtca aaagccctgt 2246941 ttaccgctta taattccatt catctgaagc gtactttgtt tcagccaagt gatgaacaaa 2247001 atcaagctct tcctgagaaa gttcatatgg ctccaaatga atgttaagac ctgtttcaaa 2247061 tccttcttta aaggctttac gagcctcatc catcgtcacc cgcttttcga tgagttcatt 2247121 aatggcaacc gctttatttt tgaaattgcg ctgcatccgc tctcttactc tttcacttgg 2247181 atataagaac agatcgaaca gcttgtcctc atctaaatca agaagaatgg agccatgctg 2247241 aagaatcaca cctttttgtc tcgtttgcgc gcttcccgcc accttgcgcc cctcaaccac 2247301 tagttcatac cacgaaggcg cgtcaaaaca aacagatgac cgcggatttt ttaagctttc 2247361 tttttctttt tcagttctcg ggatggcaaa gtaagcgtcc agaccgagat ttctaaagcc 2247421 ttgaagtatg ccttctgaaa taacccggta agcctcagta acagtcgccg gcatctcggg 2247481 gtgctcttcc gaaacaatta cgctgtatgt cagttcctga tcgtgcagca cacctctccc 2247541 gccggtcggg cgtctgacga atccgagatt atatttatgt actgcttcaa aattgatttc 2247601 ctttttaata ttttgaaaat accctacaga aagtgtcgcc ggattccagc cgtaaaaacg 2247661 gataaccggg gggattttct tttcgctgtg ccaatataaa agcgcttcat caagcgccat 2247721 attgaatgca ggacttgcat tgcctgagtc tataaaccgc caagtttctt tttgcatttt 2247781 aagaccttcc ttaccgtttt aatagaatca gtttatcaaa ctgtcgggaa aatgaaaaat 2247841 attttagttc cattatagat gacaatcacg ctgtgcttta ctataatagt atttgtcgaa 2247901 aacggctcta tgaccttgtt ttatgaagca gggttttgat tttatatgct aaaggagtag 2247961 aatcacattg tctaatatga tcgttttgat tatttttgct gcatttatca tctatatgat 2248021 tgcttcatat gtctatcagc agcgaattat gaaaacactt accgaagaag aattccgcgc 2248081 gggttaccgc aaagcgcagc ttattgatgt tcgtgagcca aatgagtttg agggcggaca 2248141 tattttaggc gcccgcaaca tcccgctttc ccagctgaaa cagagaaaaa atgagatccg 2248201 tacggacaag cctgtttacc tgtactgcca aaacagtgtc cgcagcggac gcgcggcaca 2248261 aaccctgcgc aaaaacggct gcactgagat ttacaaccta aaaggcggct ttaaaaaatg 2248321 gggcggaaag attaaagcga agaaataaag caaacagctg tctggtagac agctgttttt 2248381 atttatcttt cttccgcctc gtatctgagc actgggtgtc tcgccgcttt tgtttcatcc 2248441 attcttttta caatcgttgt atgcggggcc tcctgaacaa gctccggatt ctcctccgct 2248501 tcttttgcga tttgaatcat agcatcaata aacgcgtcca gtgtttcctt tgattcggtc 2248561 tctgtcggct cgatcatgat gcattcttca acattaagcg ggaaataaat cgtcggcgga 2248621 tgatagccga aatcaaggag ccgttttgca atatcaagcg tacgcactcc cagctttttc 2248681 tgccgcttcc ctgataatac aaattcatgc ttgcaatggc ggtcaaacgg aagatcgtaa 2248741 taaggcgcga gttttctcat catataattg gcgtttaaca ctgcgttctc agtaacagcc 2248801 tttaatccgt caggccccat ggagcgaata tacgtatacg ctctcacatt aatgccaaag 2248861 ttgccgtaat acggcttcac acggccgatc gcatgagggc ggtcataatc aaacgtaaag 2248921 cgcccttctt ttttgactaa aactggcttt ggcaaataag gaatcagatc ttgttttacg 2248981 ccgacagggc ctgagccggg gcctccgccg ccatgagggc ctgtgaatgt tttatgcagg 2249041 ttgaggtgca ccacgtcaaa tcccatatca ccaggtctcg ccttgcttaa aacggcattt 2249101 aaattagcgc cgtcataata cagtttcccc cccgcttggt gtacaatttc cgccatctct 2249161 gtaatctgct cctcaaacaa gccgagcgtg ttcggattcg tcagcataag agctgcagtt 2249221 tcttcattca ctgctctttt taaatcctct aaatcaacaa gccctttttc attcgatttc 2249281 accgtaacgg tttcaaagcc tgctactgtt gctgatgcag gattcgtccc atgcgcggaa 2249341 tcagggacaa tgaccttcgt ccgcttgaaa tccccgcgag cttcatgata ggcacggatc 2249401 atcatcagcc ccgtccattc gccgtgcgct ccggcagcag gctgaagcgt aacctcatcc 2249461 attcccgtta tttcttcaag gtgtttgctt aaatcatata aaagctctaa tgcgccttgc 2249521 accgtgtctt catcctgaag aggatgaatc gcagcaaaac caggaatacg tgcgattttt 2249581 tcattgattt tcggattata tttcatcgtg caagaaccga gaggataaaa accggaatcc 2249641 accccgtgat tgcgtttgga cagcgctgta taatggcgca tgatgtccag ctctgaaacc 2249701 tccggcagcg ctgcgtcttc gtcacgaata taggtgtctg acaagaggtc ccccaattcg 2249761 atttccggta catcgagctc cggcagacta tagccgattc ggccttctct tgaaagttca 2249821 aaaataagtg cctggtcctg attactcatg gcgatccccc aattcctgaa tgagtgcgtc 2249881 aatttcttct tttgttctca gctctgttac agcaatcagc atatggcagt ccagctctgg 2249941 atacgtcaac ccaagatcat atccgccaat catgcctttt gccagcaaac gcttgttcac 2250001 agctctcacc ggctcatcca gtttgatgac aaattcatta aacatcggcc cgtcaaacat 2250061 aacagtaagg cctgcttttt ttgcttcttg ctttgcatag ttggctttta agagattttg 2250121 gcgggctata tcttttacgc cgttttttcc gagagcagtc atggccactg atgctgccag 2250181 cgcatttaaa gcttggttcg agcatatatt tgatgttgct ttatcccggc ggatatgctg 2250241 ctccctggct tgcagggtaa gcacaaagcc tctttttccg ttttcgtctt ccgtttgtcc 2250301 gacgagacgg cccggcacct ttctcattaa ttttttagta acggcaaaaa agccgcaatg 2250361 cgggccgccg tatgctgaag gaatgccgaa aggctgcgca tcaccgacga cgatatcaga 2250421 ctgaaacttg cccggcggag tgagaagacc tagcgccagc gggttggctg aaacaataaa 2250481 catggatttc ccttgatgag cgataggctc aatatccttt agcggctcga tcctgccgaa 2250541 aaaattcggg tactgaacga tcactgcggc tgtgttctcg caaacggttt ggcgcaatgc 2250601 atcaagatcc gtaacgccat ccgcagcggg tacttcaaca acatcaatat actgaccttt 2250661 tgcgtaagtt ttcagcacct ctcgcgattc aggatgcacg gtttttgaca caacaatttt 2250721 tttctttttc gtgtggcctg aagcaagcat tgctgcttct gccaaggctg ttccgccgtc 2250781 atacatcgag gagttggcga tatccatgcc tgtcagttca cagatcatcg tttggaattc 2250841 aaaaatagcc tggagctctc cttgtgaaat ctctggctga taaggcgtat atgcggtata 2250901 aaactcagag cgcgaaatga catgatccac aatgacaggc tgatagtggt catatacacc 2250961 cgctcctaag aaagaagcgt attgtacggt atcacgattt ttagaggcca gctttgtcag 2251021 ttctcttgtt aattctgtct ctgatttcgc ttttttgatt tgatgctctt ttttatattt 2251081 gacgttttcc ggtatatcag caaataaatc atcgatgctg cttacgccga tagtagcaag 2251141 catctcctgt ttatcctttt ctgttgcggg caaataacgg tgcttcatgt gttgtctcct 2251201 ctctccaaga aaaaatatta gcgtttataa aatggtgttt tgacaacctt tgctttcact 2251261 aattttttgc gtatctctac atctacaaca gtcccgatct cactcgtttc cgaatcaatt 2251321 aaggcaaggc cgacgttttt tcctaatgtc ggtgactgcg tgccggttgt cacctttccg 2251381 acagacttgc cattttggaa aacctcatat ccgtgccgcg gtatcccttt ttcaatcatt 2251441 tcgagaccga caagtttgcg cttcgctccg ttttcttttt gttcactcaa tactgactta 2251501 ccgaaaaagt cagactcctt tttgtgcttt acagcaaagc ctatacctgc ttcaatcggt 2251561 gtaatatccc gggtcagctc ctgaccgtag agcgggagct tcgcttcaaa ccggagtgta 2251621 tcacgtgcac cgagaccgca tggaatcaat ccgtatgcat cccctgcatc gatgattttt 2251681 ttccaaatat gcatagcatc atcactgcgg cagtaaattt catacccgtc ttctcccgta 2251741 tagccagtgc gtgaaataag tgctttgcgg ccgctgatat cggcttcatc aataaacgca 2251801 aacggcttta atgcagacac atccgcatct gtcagatttt ttaagatcgc ttctgctttc 2251861 ggtccctgta cagccaagag cgcgatttga tctgactgat tgtcaatctg cacatcacct 2251921 gctgcatgtt ctttcatcca agccaagtct ttatctatat tagaagcatt aatgacaagc 2251981 agatagcggt tctctccttt ttgatagata agcaaatcat cgacggttcc gccatccggg 2252041 taacacatcg ctgtatattg agcacggcct ggcgttaacg cggaaacatc atttgtcatc 2252101 aatctttgca aaaaagacag actgtcgttc cctgacactt cgacttctcc catatgagat 2252161 acatcaaaca aaccggctgc agttcggaca gcctcgtgtt ctttttttat agaagaaaat 2252221 tgaacaggaa gctcccagcc tccgaaatca atcgtttttc ctccatattc cttatacagg 2252281 tcaaataacg gcgttctttt cagcatctaa ttcctcccct ttatcaacgg cgcagctaaa 2252341 aaacatacaa aaaaggacag agaaacacct catgtaaaat gaaggttctc tgtcctggca 2252401 cctgaaagtt tactttgcat acgcaaagac gtcccctttg gtggtttgcg catccgcaca 2252461 aacactctcc agagttgcgt cgagcaagag ttcttttgcc tgagagattc actccgcagt 2252521 ttgctccttc ggcgcctgta tcccgaggtt ttcggtcagg tctctcccct tgctgtcatt 2252581 cgctcatatt ttcatgctgt tatggacata ctatagcaat atcttacatc aaatacatac 2252641 tcatatccta ccatcatcac tatatgctgg gcaacagcaa tttgggcaga tttttcttat 2252701 attattcatc ttaagaatcg aagaataaga aaggcggttt caaagcaatg aatacagaaa 2252761 tgatctacga tgcaaaatgg cctgaagaat ttgctgaaag actgaaaaac gatggccctt 2252821 gggcaaactg ggaactgtac aagctctctg cagaaatcca gaaaacatta gcaattccag 2252881 agtttgaagg cttacgggct cctttatatc tgccttcctt tacgccgctc ccccaccagc 2252941 ttgaagtggc gcaaaaagtg gttgaaaaaa tgaacgggaa agcgatttta gcagatgagg 2253001 ttggtctcgg aaaaacggtt gaagctggac tgattctaaa agaatatatg attcgcgggt 2253061 tagcaaaaaa aattttgatc cttgtgcccg cttcccttgt gtcacagtgg gtcaaagagc 2253121 ttcaggaaaa atttttgatt ccggctgttg aacaaaagaa aagctatgtg tgggagcaat 2253181 gcgatattgt cgtctcatca atagacaccg cgaagcgctc gccccatcga gaaatcgttc 2253241 tgtctatccc atatgatctt gtcattattg atgaggcaca caaactgaaa aatagcaaaa 2253301 cgaagaacta tgaatttgtc cggaatctcg taaaaaaata ttgcctgctt cttaccgcga 2253361 cgccaatcca gaaccgtatc gaagagattt tcaatttggt gtccttatta aaacccggcc 2253421 atttaggcag tcagaatcac tttcaggagg agttcgccaa gaagaaatcc agtttagaag 2253481 cgcatgaaca tttaaaagat cttgtgaata aagtcatgat ccgtaacagg cggcatgata 2253541 cagggctgaa ttggaaacag cgccatgttg aaacagtgcc gattcaattt tctccatcag 2253601 agcaggcgct ttatgatgaa atttctcgtt tgaaggacag tatcaataaa ccagccagca 2253661 tgttctcgat tatgaccttg caaagagaat gctgttcgag cagagaagcg gtatatatga 2253721 cgctgaaaaa gatgcttgat caaaaagaga aacaagcacc tgccattgat gaggatacga 2253781 tttcagtttt gatagatcgc atcaatcaag tgacacaaaa ctctaaagcg cttcaagttg 2253841 ttgacttgat caaaaagatc gacgataagg tcatcatttt tacagaatac cgcgcaaccc 2253901 agatttatct gcagtggttt cttcagcaaa acggcatcag ttctgtgccg tttagaggcg 2253961 gatttaaacg tggaaaaaaa gactggatga aggatctttt ccgcggaaaa atccaagtcc 2254021 ttattgcaac tgaagcaggc ggtgagggaa ttaacctgca attttgcaat cacatgatca 2254081 actatgacct gccatggaac ccgatgcggc ttgagcaaag aatcggaaga attcacagac 2254141 tcgggcagga gcgtgacgtg catatttata acatggcgac aaaacatacg gtggaagagc 2254201 atattctaaa gcttttatat gaaaaaattc atttgtttga aaaagtggtc ggtgaacttg 2254261 atgatatttt aacgaaaatt caagtgaaca attttgaaga gcaccttcat gacattttgt 2254321 atcactcagc aacagaagaa gaaatgaaaa taaaaatgga taacttaacc tcatttttgt 2254381 cttataaaaa acagctgcct gctgaaaaaa gaggatctta gcctgtaagg aggttttatt 2254441 agtgagacag caagaggttc acgattttct gctgcgtttt tttcaagcaa acagctgcca 2254501 aatcgtcgat caaggcttag gctatatgac agtgcagctt acagttgaaa tggacaaaca 2254561 aatcatgaac cgccctttct actggcattg gcgcgagaag acaggcggtg atccgaatcc 2254621 aatgaaaatc acttttatta cagataaaga aaatgcgcca aaagacctag atggtgaatt 2254681 tatatatttt ggggccccgc gtctttttca aatattcaaa gctgttaaac aaaatgggag 2254741 atttaccaga atgtatgaga aaattgaatc agccggagct aaagtcccac ttcagccttg 2254801 gcttggtata aatgtcacga tttcatacca gtccgacatg aaaaaggata agttattgtc 2254861 actaggtctt cacctagtct ctggaacgat aattgaagat tttcaaagca agctgaccca 2254921 gttttcactg acgtctcaaa tatgtgacta ttgcttcacc atttcaccta tgatcaaacc 2254981 agaaagcgga cttaagcgta tggaaaacta tatttccaaa tccgctatgc aggagccgtc 2255041 cgactgggcg gaacaggcgg ttaacaggtg gaagaatgat atgacattgc ttgataagtt 2255101 ttacgagcat atagaagaaa aaccagaaga ataccatcta gaaaaacagg cgctgaaaac 2255161 cttgtatcaa ccaaagatat cagttgaaat tgaaaatggc ggattgtttt atctgcaaaa 2255221 taatatttca agctaacttt tttaccattc gacatcattc tcgttttttt tgagaaaata 2255281 cgattataat aaaggtatat tggaaaaaaa ttctggtgat ttaatggcaa atgacttcca 2255341 gagactaatg aagcatacaa taagtcatgg ccggactggc tgaaatacat aaacaagtat 2255401 tttaggagga gaaactgcat gaagaatgca aaacaagagc actttgaatt ggatcaagaa 2255461 tgggttgaat taatggtgga agccaaagag gcaaatatca gcccggaaga aatacgaaaa 2255521 tatttacttt taaacaaaaa gtctgctcat cctggtccgg cagccagaag tcataccgta 2255581 aatcctttct gaatgtgcta taatatcaca aggaaggtga tgacattgat tggccagcgt 2255641 attaaacaat accgtaaaga aaaaggctac tcactatcag aactagctga aaaagctggg 2255701 gtagcgaagt cttatttaag ctcaatagaa cgaaatctac aaacgaaccc ctccattcaa 2255761 tttctcgaaa aagtctccgc tgttctggac gtctcggttc atactttgct cgatgagaaa 2255821 catgaaaccg aatacgatgg tcaattagat agtgaatggg agaaattggt tcgcgatgcg 2255881 atgacatccg gggtatcgaa aaaacaattt cgtgaatttt tagattatca aaaatggaga 2255941 aaatcccaaa aagaggagta gtgcctgagc agaggcacta actcctcttt tgtcaataac 2256001 catcgagacg gcccagtata tgaatactgg gccgtctctt ttttttgctg ttattaattt 2256061 ttatcctcgc tatgcgcttt ttcattttct ttcacgtaac catctttatc agtatggtcc 2256121 tttttgattg tcaagccgtt ccactgtgta gcttcgaatg agaattgaag cttaatggag 2256181 ttgccttgat atttattttg aaccataagc cctttttcat cttttgtttt atcatccttg 2256241 aattggattt ccatttgaac ctgatcgaag tcagttggtg tttttggaac accatcatat 2256301 tcaggagcgg ttttaccatc aattgttgct acattgactt taccgcttgc atttaagaat 2256361 ttagggtcaa tttgtttttt gattttttca gcagccgctg catcattttt agcagacatc 2256421 aaatacaagt ctttaaggtt cgcatcatct aaaataatgt ttttcgggta gccattgccg 2256481 ccctcttttc caactgtcaa caatgtcact tcaaactggc tgaggaaatc ttctggagat 2256541 gtattgctgc cgccgtttgc tttaaaatct ccataattaa gcgccattag aacttctttg 2256601 atcgcaagtg atccgttatt ttcaaattgg aaatcctttg tcaacttatc tcccggcttt 2256661 agatttgata agttcacact cgctgaattc tctttagcag ataaatcaag cgtacctgat 2256721 gcaaaagtag catcctttga tttaatgtcg ttaaatgctg cccatgttcc tcctccaact 2256781 aaagctaatc ctagtgctgc agaagcaact cctaaactca atttcttttt catacccatg 2256841 gtaagctccc cttttattga atgattttat atcgaaacct gttgccaggt ttacaactga 2256901 agttaagtag acatggtgct gtcctttgta tctgtttcca aggcttttgt ctttctttca 2256961 atttctctaa tggcgctgct gatcgtcaca aaagcgtaaa ctaacagcat cacgccggga 2257021 acaatcaata atacagccgt tccaatcggc tggctggcaa aatgaagcat atagccggca 2257081 tatggaagct gaaaacctgt gtattgcgcg cgaacatttt cgtccgatac aggcgctgaa 2257141 tcagctgctg cattattatc accttttgtt ttaaataaca aatggtctcc ttgctttgtt 2257201 atgtcaacaa ttctgtgggt gaccgccgta tttgcatcct gcataaatgt aataacgtca 2257261 cctttttgga gctctttcac atcagtgatt tctttgacca atattaagga acctgtattg 2257321 aactccggct ccatcgaacc tgacagaact gatttcagcg tatacccaaa cactgccggc 2257381 tctcccccgg atgaacgtgt tgaaatcacg acaagtgtca gcacaataat aagagtaaag 2257441 atgatcacgt ataaaatatt actgatcagc ttcattgctt ttttcatcct cttccccgct 2257501 ttccttctgg tctgattgag tttctttttc tttggttaca gcttcttgag atgtttcttc 2257561 tttcattgtt ttttccggta tatctttttg tgttgtttca ttctcctttt tgacgtccga 2257621 ctttgtttct tttttaggga ctgtcggttt ttcatcgcat tttgcaagcc tcataggctc 2257681 cgaccactca aatgtactgc cgtttgccgg gtagcctgcc ggtttatata ctttaaatgc 2257741 ataaatgccg ggtttcattt ttttcttggt ctcaatttta taaagtgaat cgccgatttg 2257801 attggagaca aatccttttt cgatcacgtt cccatccttt aacggtttgc gggcattttc 2257861 aagcttatga agctcccact tccactttga tttcttaagt ttctcacctg tattttcgag 2257921 cacagcaaat aaggcgaaag gtgagcatac agtgcctttc gtatccgttt gatctgatat 2257981 gtgcaaatca ctttgatccc agcgtttatc ataatggcag tttttatctg tatgctgaaa 2258041 gtctttacac gtttgaagtg agacatcaaa tgtttcaata tcatgaaaag cagcgcttgt 2258101 atcatcggaa aattgtaagc atattgcggc agtcagactg aaaatgactg aaagctgaaa 2258161 gataagcaga actttcagtt tcgtcttcgc cttttgctga ttgtgaaaca atcgaaacat 2258221 atcttacctc ctgtaaaaca ctgtaacttg atatgacaat cgttctcttt aaagaacttc 2258281 acaaatagag tataatcaac gatttataga tttaaaaaca ccgaaatcgc tcattttgtt 2258341 cgtttaaaag aatgttttca tcatattaca aagtcttgct cagtattgct cattttttca 2258401 attttttaga aatttttggg attgttatgt gagaatttaa atgcatatcc cattattatt 2258461 tggtaataat aaacaaagaa agggtgacag catgatgatc aaacaatgtg tgatttgtct 2258521 atctcttctc gtctttggca ccacagccgc tcacgcagaa gaaacaccgc ttgtaaccgc 2258581 ccgccacatg tccaaatggg aagagattgc tgtaaaagaa gcaaaaaaaa ggtacccgct 2258641 cgcacaggta ctgttcaaac aaaaagtatg ggaccgtaaa agaaaagatg aagcagtgaa 2258701 gcaataccat ttaactctga gggaagggtc aaaagaattc ggcgtttttg tgacgatttc 2258761 atttgatcct tatagccaaa aggtcaataa aattgccata ttagaagaat atcaataagg 2258821 tcctccattt tttgaaggac cttattcgtt tatttgcggt tattttttcc gtttcagcca 2258881 aagtcggaag ccatagggta aaataccgaa ccactgctgg gaaacaggcg tttttgtttc 2258941 tttccgcacc tcttttcgtt cttttcgctc atctctcgga gtatctatat atttgacaaa 2259001 ttgctgcgtc atatatttaa cataatcatt cgttttcacg tgatcacctc atcattcaat 2259061 tattatgagt gttgtctcac atgacttttt ttataccctt tacactgttt tattctgtcc 2259121 atctcagcag ttttttctgt ttttggtcaa acacgatctg tgcagttctt tctgttcccg 2259181 aatccgttga cactcttaag ttgatttctt tttgttcttt tatcgatgta tcatgaatgt 2259241 aataagaaac ccgtccatat agaaattgct gcgtaccctc ctggcctttc cgttcctcta 2259301 gaacatgccg aatcgaaaga agcaccccat tttgaagcaa attctctcct atgtataact 2259361 cttttgtttc cttctcaaac atgcagcgtg aaatatattg agcagcaaca aagttcacga 2259421 ttaacagcac aagcgctgac acaaaaagaa cagctggata aataaaccct cttgtacgat 2259481 acattcaccc ccctcctaaa tacgaataga ctggaaaagc agtttgatac actttttggt 2259541 cttcactctc aattttcagc aaaacaacac cattttcaat atcagctttc atggcagtaa 2259601 tatgatctaa aatcggaaca tgccctttgc catccactct ttttcttatc attgaatgat 2259661 aaatgtcaaa acggatgtct tgtccggaaa gattggtgca gattaacacg ctcccatgct 2259721 cggctgtctt aactgcctgt gattccttgc attcattcat catctgttct atcgaaatca 2259781 tccattcctg ctgtgtgaaa ccgtcatgtt cctgctgtcg agacaaaaac agatggataa 2259841 tcgcagctaa cgatcctgat atgagcaaaa agactgagag cgaaaataat acgttaagaa 2259901 gcgtgtagcc attctgtctg caaaatgctg aggcaaaatg atttttcttt ataagctgcg 2259961 gctttgatac atacgttttg atattcgccc tcctcctccc acttcattgc atagatatga 2260021 ttgttctttg taatcgtttt tgacgcggct ccttcaccac tcatgacata tttgctaatg 2260081 ctctcattca tcatctgata gccaatttct cgtgattccg ccattttttc atcagccatc 2260141 agcttgtccc acaaggggac gactgtcagc agcacaaaca gccacaggct tagcgcagac 2260201 attgtttcta ttgtagaaaa acctttattt tctctccaca ttgactctcc cgctccctag 2260261 ataaactgtt atgtcataaa cggcatggcc ttttactcgt atttttccgc ctgcattcgg 2260321 gtgccctttc tcattaaatt ccaaacggtc ttttaatgtc agcagttcta tagaaagtcc 2260381 cgttgcatac ggacgttcaa taaccgtatc accaatgact aattgatatt cttttttatg 2260441 aaagagaatt tttgttcttt gttgacggga aatagcagtc tgctgtgtga gcataatatc 2260501 atttttcagc tgacttgctg cctgtcggac agctgtattg tcataagcag gaggaagtgt 2260561 agtgaagacg gccaccagga ggatagaggc aaggcttaac acaagcaaac tttctaaaag 2260621 ggtaaacccc ttctcctcgt ttaatttaat gttcaacctt aacttctccg ccggtgatga 2260681 taatgcgctt accatttgga cagacagcat cctttttcac atagccctct gactgtaaat 2260741 cggcaaggct cggagtttgt ccttcatgat caagctcaaa tgcagtcatt tgtgccttaa 2260801 ccatgttttg taagccttca cagccctttt tttgaatggt ttgattatgt ttcgtgacgt 2260861 tcggtatcgt aattaaaagc aaaatcgaaa taataaagag cacgattaac atttcaacaa 2260921 gtgtaaatcc tttctcattc atcagcctct tcctttcaca tttgattcat catctgatac 2260981 ataggcacaa gcatagataa atacacaagt aagatcatcg ctgcaacaaa tccataaatc 2261041 attggctgaa ggatgcctgt ccatttttgc gctttgtgtt ccagccgctg taatatgaat 2261101 tggctgtatg tgaaaagctc ccgatccaat cggccgctca gctggccgtg agatatgact 2261161 tttgataaat cagtttcata aaaaaggctt ccacaaatag cggattcaat tgactcaccg 2261221 gcttttagcc gttcaatcaa ttgttcagcc tcgcagcggt agaaagggag aaacgtttga 2261281 tgtttaaatg cattaaggct gtcataaatt gagaggcctg attttaaaag gctgcttagc 2261341 tgcaaagaaa aaaagtagct gttaaacagc tttacaagct ttccaaccaa aggaatcctg 2261401 atacaaatca gcatttgccg ggcaggtgat tttttcttaa acacaagcca ataataaatc 2261461 ccgatacctg ctgtaaaaag aacaagcaaa atgatcacaa gatcaatatg ctgaaaaaaa 2261521 gcaaaaagca tatcggttga acgtgaggtt tccatattca tcgattgata gataccggaa 2261581 aactgaggaa tgatgatgga ctgtaacata taaaacatga cagcgaccgt aaagatgagg 2261641 aaaagcggat agcgcagcac tcttttcagc tggtctgcct gtgcaatttt tcgttccagc 2261701 agctctccgc tctggatcat tgaagcaggc agttcaccat gtgtttcagc aaaataacaa 2261761 atacctacgg cttccttatg aaatgacaaa ctctttagta cttgataaaa cggagcccct 2261821 tccctcaaac aagtgaccga atcagtcaag tcagccgcct gcctcttatt catctgaagt 2261881 tccatcaggc gtaatccatc cagaagtgta tatccgcccg cagtcatttc accgagcctc 2261941 tttaataacc tggcttgatc ctttaacaac cagacttttc taatcttttt catgataaac 2262001 ccaccggtca tagttgtttg tcgttaaata gccgagcgca attccttttc tgataatttg 2262061 acgaagcgtt tgatattggt aatttgcatg atttcctttt gcctcctgga tacattgctg 2262121 aagatttttc ccgtatagaa gctcataaac gctagctctc ctagtatttc gtgactgtcg 2262181 gcaatacact gatgaacatc cgttttcaca aaacgggcaa gccaaatcaa ccaagcgctg 2262241 agccgctatt gcaatgacag tctgttcgat ttcattcata ttgataccga attcaagcag 2262301 tctgtaaatt gcgccctttg cgtctctcgt atgaaggctc gttagtacca gatgtcccgt 2262361 catcgctgcc cgcaccgcaa tttcagctgt ttccgcgtct ctgatctcac ctaaaataat 2262421 catatcgggg tcatggcgca aaattgcttt cagacctgcg gaataagtta caccggcttt 2262481 ttcattcacc tgaacctgaa gaacatcttc gtcccttgtt tcaacagggt cctctaatgt 2262541 gacaatattt cgattaaagt gtttttttgc atattgaacg agagagtata atgtggtagt 2262601 cttccctgaa ccagtcggcc cggtaaaaat gagcatgcca tgggaatgtt ttaaaaacga 2262661 gagtaatgtg gctcctgtct tcggaaatag cgacaattta tcaatcgaag ggatattgta 2262721 ttggggcatc actctgatca cgaggctttc ttcattaatt gtgggcagcg ttgacattct 2262781 taaatgaaca tttccctctt tcaactttaa cgtaagcgaa ccgttttgcg gctttcgcct 2262841 ttcacctata tccattgctg aaagaaattt aaaatgtgaa atcagtctta cgcactcttc 2262901 ttttttcatg tccctttttt tcagcaaggc atgatcgacc cgaaaatgaa tgatagcgtc 2262961 ccgctccctc ggcacaatgt gaatatcaga agcctttgtt agatatgcct cttcaatcaa 2263021 gtttttgctt accttttcta ttgaatccaa tttgattccc tctcctttca acgcatattg 2263081 tagaaaaaga agaaaaggta atcaaacagg gaaaacgtga ttttgtgaga tgttatatgc 2263141 tgaaaaacca attctttctg gcaagaaaaa agactttcaa ctgaatgtac ccctgtcatt 2263201 ataattttcc ctataaataa aaaagcagac atggtcacca tgcctgctag attccatttt 2263261 cattatgctg ttttcgctta ttgaccagta tctttctcaa cggaaagatc gcctaatgca 2263321 acaataccgg tcatttggtc attttcaaga atcgataaac tgcggattta atgctctgtc 2263381 ataagcccct tgacatcgta tccggtcacc ctgatatgtc tggtgaaaaa gcggggcacg 2263441 ctgcacaaaa tatgaaacat cctatagagt ccgccttttt cgaggtttct ttttcttctt 2263501 ccgctcctgc agcatatctc ccgtccagcc tttttttctc aaatagagat agatcagaac 2263561 tgtagatgtg acaatcaata agagggaaaa gagatatccg tatttccaat tcagttccgg 2263621 catcactgaa aagttcatcc cccataaggc acccagagct gtaatcggag taaaaagcgt 2263681 cgtgaaaatg gtcagcgctt ttacaatttc attcccccta tgtgaggtaa tgacttcctc 2263741 tgaatgcagc agattgttaa gctccccttc aaattcgctg atgtatgtaa atcccctgtc 2263801 aatcttcagt tgtgtccgct gataatcctt tttcccttca ttttgaggta aaaaggtttc 2263861 tttcaacgcc atttcaattt ttttagcgct taatatcaaa tttttccaaa tcatcagttc 2263921 atggcgcagg agatggacgc ggtttaaaat gcttttgcta ttgtcgtctt taatttgcca 2263981 tctgagcttt ctcagcttga cttcaaattc atcaacaccg attaaatacg cattcattag 2264041 ttcgccgaga agaattaaaa acccctctat cgcattgtcc gctctttcca tttgccgaac 2264101 aacttctttg cctttaatct ctctcaaaat tgaaaagtca aagttgattg taaaaaaata 2264161 ttgtctggtg atataaaagt gaaaaacagt atggtctttt tcttcaccaa gcccctgatc 2264221 ataaacaatc gacccaaata ctgcttcatt ttccgtttca gttgtatcta ctcgcaaaaa 2264281 attaacgtga tggttatttt caaaccactt ttcacactga ggccagtgag aaaaatggat 2264341 tagatctctt gccttacttc tttcttgagg ccccatttgg taccaaaacc aatcctttcc 2264401 cgtatgtgcc ttcatgtcaa gctcctccaa acttttgttc tttattcttt aattgcccaa 2264461 taaccgcgtc actaaaccag tctgccgctt caacacatgt tttatgagca ttttcaggtg 2264521 gtatggaatg tagaaagaca tcggaaaagg gaggtgcatg ccttccttgg agaaggcagt 2264581 tgttttggaa tttatcaatt tactagcagt cgctattctc attttgttaa caggattttt 2264641 cgttgccgta gaattttcaa tcgtaaaagt gcggcgatcc aaaattgatc agcttgtcgc 2264701 aaaaggaaag aaaggtgcta aagcggcaaa gcatgtcatc actcaccttg atgaatattt 2264761 atcagcctgt cagctgggca tcacagtcgc agctttagga ctgggatggc ttggggaacc 2264821 gactgtgcaa actctgcttc gaccgctttt tcataaagca ggcttaaatg aatcgcttac 2264881 ccacctgctt tcactcgtca tcgcattttt agtggttacg tatttaaatg tcgttattgg 2264941 ggagctggcg ccaaagagtt tcgccattca aaaagcagaa agcattacct tgttgttcgc 2265001 taaaccgctt atttggtttt ataagatcat gtttccattc atttggctgt tgaaccactc 2265061 tgcccgattg attacaggag tgtttgggct gaagccggca tcagagcatg agctggctta 2265121 tacagaggaa gaacttcggg tcctattggc tgaaagctat aaaagcggcg agatcagaaa 2265181 aagtgaatta aagtacatga ataatatctt cacctttgat aaacgaatgg caaaggaaat 2265241 tatggtgccg cgaaatgaaa tggttagttt gtcactagat gaagactcca tttcaaatct 2265301 tcaggaaaca gtcaagcaaa caaaatatac acggtacccg gttgtaagag aggataaaga 2265361 taacgtcatt ggcgtgatta atatgaaaga agtgctgttt tccatgctga cgaaagattt 2265421 ttcaatcaag aagcatcaaa ttgaaccttt cgtacagccc gttatccatg taattgagac 2265481 gattcctatt tataaactat tgctgaaaat gcaaaaggaa cgcactcata tggcgatcct 2265541 catagatgaa tatggcggga cgtccggttt ggtcactgtc gaggatatta tcgaagaaat 2265601 tgtaggagaa atccgtgatg aatttgatgc ggatgaagtg cctcatatcc gcgaacttgg 2265661 aaaggatcat tacttgttaa atgcaaaatt attaatcagc gatgttaaca gcctgcttgg 2265721 aaccgattta tcagaggctg aagtagacac cttgggcggc tggtttttga cacaaaacat 2265781 agacgctgag cctgaaagtg ccatagaata tgatggctac tcttttaagg taaaagacat 2265841 caacagccat cacattttat ttatagaagt taaaaaagct gaatagcccg tgaaaggctg 2265901 ttcagctgct atctttcaag ataaacatgg caaaggcatc aacactcttt tattttaaac 2265961 cctttattgg ccagggcttt agcaagactt tgctctgttt tcacattcga aaaatccaga 2266021 cccagcttca cgacagtttg ggcaatttcc ggcctgattc ctgaaataat agtctcaatg 2266081 ccgagcaatt tggtgctgtc aatcacttta aaaatttgat aggctaccat ggtatcaacg 2266141 ataggaacgc ccgaaatatc taaaaataaa tacgagagct ttaacgctga gcactgctcc 2266201 agcacagact ccaaaatcgt cctcgctctg tgcgtatcaa tttcaccgac aagcggaaga 2266261 atcccaattc catcagtaat cggcataatc ggcgcactca attcattaat catttctttt 2266321 tgcgcgttta attgtatcat ggtcacctgg tgatattctt ccgtaaacac ttcgatgatc 2266381 tcatcaatgt tttgattcaa gatccggctc cactcataaa attcctgaat gctgatgtct 2266441 tgagaagaag cttcgctgaa tttatgaatc cattcaaaca tgatgtgcct gaaagtgtta 2266501 aactggccga cactttgtgt aaccgtcact tcatgaacgg cacggtctct ggcgcattga 2266561 agagaccacc ggttgagctc atcctctacg tcttcttttc taagggattt tgctacgatg 2266621 gtcaccaata attcatgctg gtcttttaac ttttgttcta gtttttgctg atctttcgct 2266681 gaatacagcc agctgccgtt tgacgtacaa acttccagcc attgttgcgt aatatctttt 2266741 ttgtgctctg ttaagtgctg atcaagagct atcatcttaa tgagttacct cctgtttttg 2266801 aaaaatgtac gctatatatg tataacgcgt ctgcctttac acatactatg tttagattca 2266861 atgggctata gccaagcggt aaggcaatgg actttgactc cgtgatcgtt ggttcgaatc 2266921 cagctagccc agtttctgaa caggtgaaaa accgaagata agctgattcg tataaatcag 2266981 cggatcttcg gtttttcatc atgcagattg atgaaccgtt ttcttcttcg ataacttcaa 2267041 cagttctccc gggttataac caatcaccag ctttttgttg tctactagaa tcgggcgtcg 2267101 caaaagcttc ggcttctcga ttaaaagttc cagcacctca tttaccgtca tttcttcaat 2267161 gtttaaattt aaatttttga aagtctggct tcttgtcgcc aaaatttcat caattccttc 2267221 tgtcgttaac gataaaatgt actttaattc ttctcttgtc ggggtttctc tgaataagtg 2267281 ccgttcgtta aattcaattt gatgtgcttt aagccaatgt tttgtttttc ggcatgacgt 2267341 gcagcttgga tatgagtaaa aagttaattg ttgttccatt cgttttttcc tcctcagtta 2267401 accatctctt tgtagaataa ctacccggat catttttcat ttaaaccatt tacagaactt 2267461 ttttcggatt attttttaaa aaacattcat acaatagaaa acacaatcaa agggacaaat 2267521 tccatttgta tattaataat gaaaatgttt acatttctag gtgtgatcta ttataataac 2267581 agtcagaggg actctcggga ggggataaaa atgaatcgca tgttccgggt gttaggattt 2267641 tggacgggaa tttttgcagt catgttttat ttaggtgata tgaaagatgc ttccctttta 2267701 ttttttggac agacgatctt atttgtgttt ctatcgtatt tgaacttaac cgaacgcatg 2267761 tatatttata tttttggcgc ttatttaaca attttcttcg ccggctttac atattactca 2267821 atttttatta tggtgcccgg cggcggaggc cattaaatgc agaaagagac aaaccttatc 2267881 ggtttgtctc tttttttaca atgaaaaccc atttaaaaac ggattttgat cctgctcagt 2267941 cagtacgtct gtttcaggtc catggccgct taacaccagc gtgtgttccg gaagcgtaag 2268001 cagtttttca tgaatggacg tcagcagcgt ctcttgattg ccgcctatta aatccgtacg 2268061 tcctataccg ccttggaaca agacatctcc ggaaatgacc aagtctgcat ctttcacgta 2268121 gtaagacaca ctgcctggtg aatgtcccgg cgtaaataat gtttccaaat gaaacggccc 2268181 gatattcaac tcaccgtcgc cttcaattag atgatctgca ggcttagctg tgacttctat 2268241 ccctcgcagc atgccggagc cgtttaaaga agcgtccgca agccaatttt tttcattttg 2268301 atgcaggtaa acagggatat cccatttttc tctcacttca tcaagcgccc caatatggtc 2268361 aaaatgggca tgtgtaagca aaatggctaa aggcgtcagc cctttttctt ttatgtattg 2268421 attgatttta tgtccctcgc cgcccggatc aaaaatcaga cattgatcat cactgatgag 2268481 aaaatatgcg ttcgcttgaa tcggccctac tggcattcgt ctccatttca ctattatcac 2268541 ctctttcttt tttatgctct tattatgagg gtttttgaaa aaagattcaa acaatcgcaa 2268601 tgaaaacgct atcgacaaac ctataaaaaa caggtagaat aaaactggaa agaattgcag 2268661 gtttttcaat gtaaaggggg ctgtgttatg ttacttgtcg tgattttcgg ccttgtcgct 2268721 cttttcgctt tatggggagt cttgcgttct gttagaaata aaaatatact cgggttttta 2268781 ttagccggtg ccaccttatt tgtctttgga tggtttaccg tgatgaccgt aataaacagc 2268841 gggtatccaa ccgcacatta aaacctgtat ccgatcggat acaggtttat ttttatggct 2268901 gtaaatgttt attgacactt tctattttgc tctcaagcgt cgtttttttg tcacgcctgt 2268961 catcgatacg gatattcgtt gccactctgt gcaatccttt ttgaaatggc gcttcgtgaa 2269021 ttgcctgaat aactgcaaaa aggtcactga gttctccctc gatcagcgta ttcatcggtg 2269081 tcagctgata tttgattttc ccttctgctt gatatccttc taatatcttt tgcacatcgg 2269141 ctacgtaagc actgacactg ggtgtttccg taccgattgg gataatggtt acatctgcga 2269201 tagccatcgt tattccatct ccttttgatc aatgatgagt tgcttcgttt catgtgattt 2269261 caataaaata atttgctcaa aatgaaagcc gtataacgca tatttcccgt tcggagatat 2269321 ttgaatcggc tccatttccc gcagagacac aagatctttt gtctctcccg atgctacatt 2269381 gattgctgcg agcttatatg catcgccgct ttgtttgaat gtataaaaca ggcctcctgc 2269441 ttcatcatag tcatactcca ttggagccaa acttgtatat ttcgcttgga gcggccattt 2269501 cgctgtaaca ggtgatgttg attgcggcgt tttaaactga tacgtccctt ttcctccgga 2269561 agctgatttg acagtaaaac tcatttgatg gaaagaatcg aagaatagaa cgttatcctc 2269621 aagcttctgt tccgtcttag aagctgtatc gaacgtatat aaaggccctg ttttatcgtc 2269681 tctaccctct tttacataat caaatgtatt tttggatgtc caatgaatga acggaacctg 2269741 tactgggctt aagaaagatt cgtctttttt agcattcacc tgatatgtat ggaaatccca 2269801 gttttcattg aattccgtca ccatcatttg ataaggatca tactgattcc aagcagcttc 2269861 aagctcatac gtttcgtaat ctttttcgta aagcgtctct ccttctgcat taagcaaaac 2269921 cactgccgtc ttttggctat gtgtgatttg cagcagaatc atctgctccc tcgcattgat 2269981 ttgaacatca acgatttgac catccgtttg atagagcttt ttcgctttgc ctgtaaagat 2270041 gcggtacgca aaaagctctg ttttcgtcgg attagacgca gtatataata ttgtgctgtt 2270101 attcagccag ccttccgccc catccgcttt ttccgcggaa agcggtatga tgtctttttt 2270161 ctcatctttt gccgccgatg cctgtttttg ctgctgatga gatggttcgc atgccgataa 2270221 actaaacagc aataccgcca gcagaataaa acaaactgat ctcatcagca ttcccctccg 2270281 atcatcttta ttctctcata tttgcttcgg cagaaaaaag aaaaagtttc agttactcat 2270341 gaaaaaataa cgccctccac aagataccgc ttgtggcgtt atatatgtgt gaaaactgct 2270401 gaaacggcaa aggattttgg ccttttccaa gttccaccgt atacccttcc ttaaaataat 2270461 ggtgaataaa ccaatcacga aatccagcat agctgtctat atcccttact cccttataaa 2270521 tgttcccgct taactcctca aactccttta tgacggcagc agattcctca ggctcaaggc 2270581 ctttatagcc ccaataaatt tcttctcctt gagtatgaag agccagcagt ctgtcaggcg 2270641 gattctccgt gatcagccgg tacatcgcaa tagattccgg ctccgtaagc ggagagattc 2270701 ccggaaaatc gcggtagctg ggtgctgtcg gttttcggta tttttcaatt tcccataatg 2270761 atggaaattg tttatttaaa tcaaccccgt ttatattcgc cttccattca ttaaaatttg 2270821 gacgatgttc atttagcctt tcgagttcat ctcttctggc tcccatgact tctgatccgt 2270881 ttaaaacaag atcaacgcca tccggattga caagaggaac gagggataag gatgtgctgt 2270941 taaacagctt tatgggagaa aagccaaaga aaggcgaatt gcagcataat gacatacagt 2271001 attccttaaa ccattttagc aggacagacg ttgtaatcca ctcattcgca tgaaatgacg 2271061 cgttcatatg gacctttttt acggcatgct ccccaccagc cttcagctcc cagataggcc 2271121 tgccgagtac agaacggcca atttcccggc atgagacaaa cggaaaaaca tcaataatct 2271181 tctttatttc cttttcaaca gctgaatcat catagatttt ctcttgctca atccagctat 2271241 ctgaaagttt cagctgccga ggctgtaaaa agcgctttat gtcctgaatg gtttgaagct 2271301 ctttgccgct atgctcctct atcacataac cagggcaata caattgatgt ttttgtgcgg 2271361 agcgatttgc acttttaagc aattcctcgt ctatcttcag ttctttcgcc acattggcca 2271421 aattgttctt gatctcaggt ttcaccgtaa taaacgccat catcatcccc cttttttgtt 2271481 actatatgac agcgtattta aaaaaagaaa gcctcccgct cacttcgatg cgggagacat 2271541 tgtgattatg atgcctgatc aagcatttgt ttttctttcc gctttgacga attgtccagc 2271601 cttttctggt cataaaatcg caacaaatcc ccataaatga tttcatcaga aagtgatagc 2271661 tcctgttttg ctttatcagc aaatgcttca cattgttttg tctcttctaa cggttttccc 2271721 gtctctttgt cataacacgc accgtctgta taaacaacct gatctgtgat aaagctcccg 2271781 tcccggagca ccgtgaagtc cagtttttcg tctgaaagca gatcgttgcc gaattgaatt 2271841 tgatctttcg tatcaatccc taaaagattc atcagcgtcg gcctgatatc aatctgcccg 2271901 cctactgttt caatggtttg cggcttttta tcagtaatac ccggaatatg aatgaccagc 2271961 ggcacttttt ggagctgtac ctcttcaaat ggggttattt cttttcctaa aaactgcccc 2272021 atcgcttcat tatggttttc tgatatacca taatggtcac catataatac aataacagag 2272081 ttgtcgtata acccgtcttc cttcagcttt tcgataaacc gtttcagcgc ctcatcctga 2272141 taacgcactg tcggaaaata tttatttagc gtctggctgt ttgaatcata ttcatcaatc 2272201 aattgatcct cttcatcaag atcaaacggg aagtggttcg tcagtgtaat cagcctcgag 2272261 taaaacggct gaggcagatt tttcatcagc tctgaggact gctcaaaaaa ttctttatcc 2272321 ttaagtcccc agccgactga attttcgtca gttacatcat acgagttaat atcaaaaaac 2272381 gaatcatatc caaatgagtc gtacattaaa tcacgattcc aaaagctctt attattagcg 2272441 tggagcaccg ctgaatagta tccgctgttt ttcaaaattt caggagcggc catatattga 2272501 ttgcccgcat tcgtaaaaaa tacggcacct cgtccaagcg gatacagtga attgtccacg 2272561 ataaattcag aatccgaggt tttcccctgg cctgtttggt ggtaaacatt attaaagttg 2272621 tagctctgtt ttataaagtc attcagaaaa ggcgtgattt cttctccatt caatttttca 2272681 ttaatcacga agctttgcgt cgactctaag gatacgagaa tgacgttcct tccttttgca 2272741 gcgccgaata agcgtttgtt ggcatccttc gcattagcgg ttacgtagtt ttcaatctcc 2272801 gtcaggctgt tgctgtctgc caacgctctc tgtgcggatt gctttgactg aagaacgcca 2272861 tcgtaaatat gaaaattaaa caggctaatg tttttaacaa gcatttctct gtcaaatgag 2272921 cgtgtcaata gctgaggtct ttccgcctca gacaagccca ggttgaagaa ataaacagaa 2272981 gcaacgaaca aaaaataagc cgcccgttca tttttcgttg agggaatgtc cgattgaaaa 2273041 gctttttgcc ggatgtgaag ccatattaaa accgcaatat ctacagctaa taggaggtct 2273101 gtcggctcaa gaagtgttcc gatgctgctt ccgagatcac ccatattgct cgtttgaaaa 2273161 agaacaggga ttgttaagaa atcattgtaa aaacggtaaa aaaccatatt tgccagcaat 2273221 acaaacgtga caagacagct catcgcgata atgtagcgat ttctgttttt gccttttaaa 2273281 aacaggctga ggccaaaaat aagcaacaaa aaactcaatg ggttgataaa cagaataaat 2273341 tcctgtgtta gattgtcgat tttaatatga aaactggttt tgtaaacagc atacgttttc 2273401 agccacatca ataaaatggc aatcagcata aatgaaatct tcgaaaaaaa cgtttttcgc 2273461 atttcaacct cctatgcagc acgctcaaaa aaatcagtct attcccaaca ttctcattaa 2273521 cacatcaaat taaatcttaa cctgagcaca acaaaaaatc aatttcattt acacaatttt 2273581 aacaattttg atgtttcagc cattcatttt tagcgatcca agcgcctccg ataacgccgg 2273641 catcatttcc aagtgctgcg attgaaatat cagcagcttg ggctgcccgc ggaaacgcgc 2273701 atttgcggaa tgttttctcg acttttgatc tcagcagttc tccggctctc gatacgccgc 2273761 cgccaagaac gattttggat ggattaagcg agcttgccaa atttccgagc accaaaccaa 2273821 gatgcttggc tacataatca accacctcaa gggcaatttc atcattttca cccgccgctt 2273881 caaacacatc tcgcgctgac aattgttcgg ttgcttttaa acgtgtcgtc tttttagcat 2273941 ttgctatttt ttcttttgca attcttacaa ttccggttgc tgacgcaatt gtttcgatac 2274001 agcccgtttt gccgcagttg cagggcgctc cgccttcagg gatgctgcaa atatggccga 2274061 tttctccgcc ggcgccattt ataccatgta caatttcacc atttgcaatg atgccgccgc 2274121 caactcctgt gccaagcgtc acgagaatga cgtcttttgc gccatcaccc gctcccttcc 2274181 acatttcccc gagcgcagca atattcgcgt cattttctat aacagctggg atgccggttt 2274241 ctgtctccag atggtttttc aaagcataat ttttccaccc tagatttact gtttcataaa 2274301 ccactcctgc cgccatatct acagggcctg gtgcacccat tccgatgtat ttgatgatgt 2274361 gcttcggttt ttgcagctca tccagcttgc tgtcgattgt ttttgcaatt gtgacagtaa 2274421 tcgtgtcgcc ggttttatct gtcggaactt cccacttatg ctgaatttcg ccatattgat 2274481 taataaaagc gagtttaatc gtcgttcctc ccaggtcaat gcccgcaaac catatctcgt 2274541 ccatttttat caccttagcc tttataaaaa tctcttccgt tttttgtttg ttccaattct 2274601 tttcgaagga cagctgccgc tctggcccac tgctcctttt caatcatgtg gttcatgtat 2274661 aattccttta attcatccag cataaactca atttcaagct ctctgtctcc aaaataaaca 2274721 atgtggccaa acgtttttaa cagctgctgc acatcataaa atgtattcat tttcctcacc 2274781 atttcttgaa cttaactatc ataagcgtat tcataaggaa gcggtcagtc aagaagaaaa 2274841 cgctgacaaa aaagccagct tcctttccat attccacctc tatgattctt tattgttttc 2274901 aatttgccgc tgcagctcct tgtagcgctg ctccttcggc ttcagtttca cagccgtctg 2274961 gatggccttt tctgcttgtg caagctcatt tttttccgca tacaataacg ctaaattgta 2275021 ataggaagca tggtctttag gttctttttt cactgctcgt tccaaaaggg aaaccgcctg 2275081 atcatattcg ccgatttgaa tatcagaaac agcaagaatt ttcaaaagat cggcagaggc 2275141 atctttttgc gctgcttctc cgttcagcaa ttctgttact tcttcatact ttccttcctg 2275201 atacagctcg cttgcctgct gaatcagcgc tgactcctgg tgtgaaggcg aatgcaatcc 2275261 gtaatataaa aatccaacag ccaaagcaat cagcaaaacc gctgacaaca atctttttcc 2275321 aaaggctccg gctttaggca accccagtgc tgctgcagcg aaaaagccgc caatcaagcc 2275381 gccgatatgt cctgaattat caatattcga aaccgcaaaa ccaaagccca gattgatgat 2275441 aataatgaca ataatattgg ttcctatagt tcttaaaaac atttttcgat tagacaaagc 2275501 aacatacagt aatgcaccta agcatccgaa tatggctcct gatgcccctg ccgaaggata 2275561 cgggctgaac acaaaactcg caatcgaacc cgtaatgcca gcagccagat aaatcagcaa 2275621 aaatctcccc gatccataca tccgctcaac cgctgtacca accgaccata aagccagcgt 2275681 attaaaagct aaatgcgcta tgccgatgtg aagcacgatc ggtgtcagaa gccgccacca 2275741 ttctccttgt gcaatcaggc tgttttcttt tgctccaaaa gccaccagtg tctccgtatt 2275801 agtgctgcct ccgtttattt cgagcaagaa aaacatcagg atctgaagcg caataaataa 2275861 atatgtaaaa gtcggttttc cgttttgaaa aaccgccgct tcagtttttc tctgttcttc 2275921 ttgtttcagc actagcgaaa ggaagcgttc tcgcgccatt tgcgcgtttt caaacgaagc 2275981 gtgttcctct gaacaatctt ctgtacgaaa tgatggaaaa accgcttgaa gatcatctcg 2276041 aagcatcgtt cctctaacga tcgccggctc aactgacaca gttcccttct caaaagtttt 2276101 ttttgcaatc tcttcccagt catcaactgg ggcttccgtt gaaaaaaaca cgttcagcag 2276161 cttcatcctt cgtctgccca attgatgtct gactcgttct actcgttcgg cctgctcttc 2276221 gatgtctcta accatttctt gacggaaatc aagatcgtgc ttataaagac gaactagatc 2276281 atgagaggac ttgtccggcg cttccagcca tatttcatct gactcaccgg cttgtatgac 2276341 gccatacccg ctattcacca ggtgcgccgc aattttccaa tatgtatact ccagcaaaaa 2276401 catgtttacc gctccaatag ttttttttca ttataacagc tggcgctccg aaacgcctac 2276461 tgaaagcaaa aaatcccgtt tttcacggga ttttagaaag cttgctgtat aaacttattg 2276521 cggataaatg gaattcttaa aaacaaatgg ataaaagacc gcctgattcc tggctggctg 2276581 agtacagtat tcataagacg gtagcgattt tgataaaaca tgacggcaga aaccgcgaaa 2276641 atggcatata tcaaaagttt tttcatgata tccctcctgc caatagggtt tgttattcta 2276701 ccttatttat tctcgaataa gggacaggaa agttatgaaa aacaagaaat aatccgatcc 2276761 tctgttatca gcttatgtac cgggatgtca tgcggcagac ggggtacgtg cgcaaacaac 2276821 tggcactcca aaagcaaaga gactgtcttc ccttcatatt cacttaaata gcgatcataa 2276881 tagccgcctc caaagccgac cctaaacccg ttaacatcaa aacaaacacc cggaacgatc 2276941 atcaagtcaa tttgtgatgg gtttacttct tttgtttttt caattaccgg ctcgagcagt 2277001 ccggcgtaca cggtttcgag ctgatcatca gtctgatatg tgcgaaattg cattttcttc 2277061 gtgtccggat ggcattttgg gatgcaaact tgtttccctt cttcccaagc ctgctcaatg 2277121 acaggacgcg tcggtatctc taatcctctg gaaatagtga cggcaatggt gccggcattt 2277181 tgccactccg gcagagaaaa caagtactta tacatacgtt ccgttttttg aagaatatct 2277241 tcatttgata aagcagacag tgcctccagc gtcttttttc ttaattgtga tttcatctct 2277301 catccccctc ggaatagaaa aaaagccaga acctttttca aagctctggc ttttttctta 2277361 cacctcaaac agcaaagctg ttattttgtt tcacggtgta acgtagattt tttatcacgt 2277421 gggcaatatt ttttaaattc aacgcggtct ggattgttgc gtttgttctt tttagaaata 2277481 tagttacgct caccacattc agtgcaagcc aaagtaatat taacgcgcat tattttccct 2277541 ccaaactaaa atcatttact tattcagact tatatataat accactataa tggacggaat 2277601 gctaggctgt ttttcaatga attgctgaat tattgaagat acgctcataa agctgcaaat 2277661 atgatgacat aatgagtcgg gggtggtgga gcttgaacac ttgttgtctg ccagcttctt 2277721 ttatccggcg ggctttttcc cggtctttta aaaaactgtc cagcagatca gcagcttcct 2277781 gtacgagcgt aaaatcagcg atgattgccg ttttgtcatg aaccgcataa tcacaaaaac 2277841 cacctgactg agaaacgaca gtcagcacac cttgttccat gctttcttgc gcggcaagcc 2277901 caaacggttc ataagaacta gggaaaacag ccatttcaca gtgagacagt aacgttctga 2277961 tatctttcct atttagaaac ggcagaaaca tgacgcgatc cttcaggtta tatgccgcag 2278021 ccaatttctc atagcaggac agagacggcc cctccccagc cagcactaga tagaggtcag 2278081 gctgacgctg cttcaagatg gcaaacacct ttaacagctg cgataatcct ttttccggaa 2278141 caaaccttcc atatgaaaag aggaatcttc tattcatgct tctcgggatt ttccccttct 2278201 cttcctccat agatgcaggg cttgggataa cggttatttt cttatgtgcc gccttatcaa 2278261 gagaccgctt cataaatgtg cttaatacga tcaatgcatc agcggattct ataaggagcc 2278321 gttcggtcat gagcctgtat gggtgtgggg cttctcggca caccttcttc ctttcgcttt 2278381 caagaccgtg gattgtcgca gcaagcggaa ggccaagccg ttgtttcaaa tactgggcgg 2278441 caggggcagt tgtgtcatca tgggcatgaa tcagatcaaa gcgtttattg tgtgataaca 2278501 catggcgaac cattgtaaag ttagcatcag ctatgtaatc ttcaaacttc gcatacgaaa 2278561 acagctgccc gctcggagta aaaaccgtaa tgttgatatg agggtttaaa taggaaatga 2278621 ggcggtttaa atggacaccg agcccgcttt tcggctcatc gggatgttcg ggtgaaagca 2278681 tgagaatgtt caccgttctt tttcccctct cccataacag gtgtatgcag aaaattgcgc 2278741 ctcccacctg gtgtgcgctt cttcaatctg aaaactgttt atatgacgaa tcccattttc 2278801 atcaagatag atgtcgtctg taccggcaag cttgagagag acattcattg aattcacaat 2278861 tctgtattca gcccgatata cagcatcacc agccgcctgt ctaatcgtcc attctccttt 2278921 atcatacgtt gtgcgttttg tcctgacagc ttcaatgtct tttcttttga tgacaatgcg 2278981 caattctttt atcatatcct gcgttttttc gaaaaggacc gcttcagcca gccgcattgt 2279041 ttcttctgag atttcccagc ttacggtcaa ggtgtgagcg ttttgaatga ttatgtcgaa 2279101 tgtgtcccta aaaaaggaaa gcttatgtcg tatattatag ggaaatgggt gtttatccat 2279161 ggactcctaa cattctcctt tccaatcgtt cacttcgtgt tcctattaaa ccattacatg 2279221 aagaagaagc gaagaaagat ttctcgacaa aatctcgttt ttttcgcgaa ttcctttaga 2279281 aactattggt tttatggtat aaaaaagaag gataaaaaaa gaatagaagg tgatgaaacg 2279341 tggaaattgc tattattgcg ttgtttatcg tcagtatagc gctaattgca ttctcatatt 2279401 ctcaaagaga cccgatgaaa gatgtagaac aggagctcga aacactgcag ctttctgcga 2279461 tgcaggaaat ttacaagctc aaaaagaaaa tgacagtgct tgaggaagaa ttactggaaa 2279521 caaaccttgt cattcgcaaa tcaaagcaga acgacatcaa tcaaaaaatc gctaaacaaa 2279581 tactttctaa atataataac ggtatgtcag ctgaagcgat tgctaaagct gaacatgtat 2279641 cagtggaaga cgtgaatacg attatcaaag ataatgagaa ggtgctcgta tgacaaaacg 2279701 gggcattcag gcatttgctg gcggcatcat tttagcgaca gccgttcttg cagctgtttt 2279761 ttatctgact gacgaagacc aggccgctgc tgtaaaagat aataaaacag taaccgaaca 2279821 agacgtgaac aattatcttg attctaaaaa attggtttct gtcaaccgtg atgaatatca 2279881 aaaacttctc gattcaaaag agaaatcctt aaacaatgac agcggctcag acacgaaatc 2279941 agacaaagtc aaaacctaca agctcaccat taaagacggc atgagcacgg cggatgtatc 2280001 tgctattctt gaaaaagagg gcattatctc ttcggctcaa gactttaatg actatgtcat 2280061 tgatgccggc tatcacaaag aaattcgtgc cggcgagttt aaagtaaaat cagacatgag 2280121 tttcaaaaag atcgtaaaaa cgttaacacg ataaaaaaac aggctgactc agcctgtttt 2280181 tttcatccaa actttcctga aatgtaatcg agcgttcttt ggtccttcgg gttagagaac 2280241 attttattcg tattgtcgca ttcaacaagc tcgcccatgt agaaaaaggc ggtttgatca 2280301 gaaacccttg ctgcctgctg catgttatgc gtgacaatga caattgtata tttatctttc 2280361 agctctagaa tgagttcttc aatttttctc gttgagattg gatctagtgc agatgtcggt 2280421 tcatccatca gcaaaatatc aggattggtc gcaagtgctc tggcgatgca aagacgctgc 2280481 tgctggcccc ctgacagcga aagagcggac gtatgcaatc gatccttcac ctcatcccat 2280541 aacgccacgt cttttaatga cttttccaca atttcctgaa gcttcttctt atttttggtg 2280601 ccgtggactc tcggtccgta agccacatta tcaaaaatag attgcggaaa cggattccct 2280661 ttttggaata ccatgccgat attttttcgc aaatccacga tgtccacttt atcctttaaa 2280721 atgttgctgc cattatagtt cagctcacct gcaagcttta cattcggcgt catttgaatc 2280781 attaaattca atgtcttgat aaaggtcgat ttcccgcatc cggatggtcc gataatcgcc 2280841 gtaacctcat tttcataaat gctcaaattg atatttttta aagcatgatg ctgcccatac 2280901 cataagttca ttccattgac ttgatatact tcctgtttca ttacagcttc ggtagcaata 2280961 ctcattgccg ccctcctatc cgaatttccc gttaatataa tcctctgtct tttgcttttt 2281021 cggactcgtg aaaatctgtt cggtctgtcc gtattctaca agctcgccgt ttaaaaagaa 2281081 tgccgtccgg tcagaaaccc gcagagcctg ctgcatattg tgcgtgacaa taataattga 2281141 gtattctctt ttcaatcctg taattaattc ctctattttt gcatttgaaa tcggatcaag 2281201 cgctgaagct ggttcatcaa gcagaagaac agccggcttc atcgcaagcg ttctcgcgat 2281261 gcataaacgc tgctgctggc cgccggataa cgagagtgcg gatgaatgta aacgatcctt 2281321 cacctcatcc cagagcgctg cttttgttaa actttcttcc acaatttcat ctaaaacagc 2281381 tttattccgc tctccggcat atttcaatgc atgtgtgata ttcgcataga tcgatttcgg 2281441 aaatggattt ggtttttgga aaaccattcc gatttctctt ctcaagctga caacgttaat 2281501 attgccgccc aatatattta atccctcata aaggatttca ccttccgctc ttgcagatgg 2281561 aattaaatcg ttcattcggt taatatttct caaaaaagta gattttccgc atcccgacgg 2281621 cccaattaaa gcagtcaccg catttttttc aatatccatg tttacatgat gaacggcttg 2281681 tttatttccg taataaatgg acagatcttt gacctcaagc acgtggttct gcttcggaac 2281741 aataacagct cgctcaggtt tttcttttac catttgttca gacatgtttt tcgcctcttt 2281801 ccgttctaat ttgccgtaag ctttttgtag atcatcgtgc caagccatct cgccgcgaga 2281861 ttaaacacaa gaacagaaat caccagcacg gcagaaccac cgttggcaat cgcttcagca 2281921 tccggaatca ttccttgtgt attgacgttc caaatgtgga ccgcaagtgt ttcagcgggc 2281981 ctgaaaatat taagcggtga tgtttccgaa aacgggttcc actccgtaaa attaagacgc 2282041 ggtgttgtca ggcctgccgt aaataataat gcggccgctt ccccgaacac ccttcctgac 2282101 gctaaaattg ctcctgtgat gatagaagga atcgcacttg gaattaaaac tgtttttacg 2282161 gtatgccagc gtgatacacc taaagcgaga gaggcttcct tcagatcttt agggactgaa 2282221 cggatcgcgt cttctgtcac acgcaccatg acaggaaggt taaaaacagt taacgcaagc 2282281 gctccgccta tgatcgtata accccagcct gttaagttga caaacatcaa taatccaaac 2282341 atcccaatga caatagacgg aagagatgaa agcacctcta tacatgttct aatgaagtca 2282401 gttactttgt tattaggcgc gtattcagcc atgaagactc cgccgcccac accgagcggg 2282461 attgtaatca gcattgtaat aaacaaaata taaaaggagt taaacagctg atctcgtatg 2282521 cctcctccag ctgcaatggc gctcgacttt gttgtaataa attgaaaact gagctgagaa 2282581 acaccgttta taataatata ggaaaacaaa cctactaaaa tggcagcgat aatggctgca 2282641 cacaaaccaa acattccggt cgccagttta tctgttattt tgcggttcat tacactttcc 2282701 tcctagatga caagtagcga ataagcagga tgaacaagaa tgacatcacc agaagcacaa 2282761 gccccattga ccacagcgta ttgttttcaa cacttccgta tgtggtgtgg cccatattca 2282821 gcgtgatgat cgttgtcagc gttcccgcag tgtcaaacgg gctttccggc aatactcttg 2282881 tatttccaat gaccatctga acagccaaag cttcaccgaa cgcccgagcc atgcctaaca 2282941 caacagctgt catcaatgtt ggaaaagctg caggcacaag tacttttctg atcgtctgcc 2283001 atcttgtggc accaagcgcg taagaaccct ctcgtaaact cttcggaaga gaagccattg 2283061 catcagcaga aatcgatgtg atcgtcggca gaatcatgac ggaaaggaca atcgttcccg 2283121 ccaataaact gtgccctgtt ccgctcgatt tgaactgggc gataaacggc accaatactg 2283181 taagacctat gaatccataa acaacagatg gaataccgac taaaagctca atcaccggct 2283241 gcagcacttt ctttccccaa ttcggggcaa tctctgtcat aaaaatcgca cctgcaatgc 2283301 caagcggcgc agcgattaga gcagaaagaa tcgttactgc aaatgagcca aaaataaatg 2283361 gcagcactcc gtatttcgga tcactatctg taggattcca atttaagctc gttaagaatt 2283421 caattgggct tacaccattt acaagaaaag attgcagccc cttaacgccg aggaaaatgg 2283481 taatcgcaac agatgccgca atcataatca gtgcacaagc tgtgactatc attcttcccc 2283541 gaacttcatc caattgccga ttttgcctag agctgattaa gcgctcgctc acagacatat 2283601 tttctctatt gtttatcatt gttttacact cctatgaatg tgttaagagg agaaacggtt 2283661 gtccccgcac tcctcttttt attaagatca gctttgcttc ccgttggcat cacgtgtcac 2283721 tttcatatca gtaaccggaa tgtagccttg gtcagtaaca atgctttttt gaatgtcttc 2283781 actctttaga taatcaagaa attctttagc taaacctgtc gcttcacctt ttgtataaga 2283841 atgttgataa gcccagatcg gatactcgcc agttgctaca tttttcgctt caggtttaac 2283901 accgtcaata gatagagcag ttactttgtc atctgttaaa tatgagaatg caagatatcc 2283961 aatcgctccc ggagtatcag caatgatctt tttcaccgtg ttggaggaat cttcagtaat 2284021 gccttctgca ggctccgctc cgtcaagcgc atatttcaca aatgtagcac gtgtgccgga 2284081 agaatcaggg cggtttacaa gtgtaatctt ttggtctttg ccgccgagct ctttccagtt 2284141 tttgattttg ccagtgaaga tttttttcaa ttcatctttt gaaatatcct ttacaccagc 2284201 atcagggttt acagctgctg ccataccaac tacagcgact tgatgatcga caagcgcttt 2284261 tgcatcgatg ccttcttttt cttcagcaaa aacgtctgaa ttcccgatct gaacagctcc 2284321 ttcagagact tgagaaagcc ctgttccaga accgccagct tgtacctgta tatcagcatc 2284381 agggttttct tccataaatt tttccgcggc tgcaagtact agtggctgca ttgccgatga 2284441 accagaaatg gttaaagaac ctgatgcctt ttcttctcct tttgcagaat cgctattcga 2284501 ttttttactt tctcctgcat ttccgcatgc agctgcaatc atcataaaag cagccatcag 2284561 aagcataagc accaatttgt tttttttcat ttcctgaatt ccccctgcgt ataatgtgta 2284621 atttgtccta cacgtataga gtaaaggttc tatgtaaaaa gggtttgaac cgaatgttaa 2284681 ggttttgtaa atcagtgcgt ttttttgtat aaaaaaaacg cccacatcat gtgagcgttt 2284741 ttttttagtt atcagaagac gttgtgtttt ctgcattttc ttcaattttg tctttattct 2284801 tttgctgagt accttctttg tcctgcttcg atttcagctc aaaatattta tccattactt 2284861 ccctgccgat ttcgtttgta attgagtatc tttgattgta atcaatgtaa gtccaaggaa 2284921 ctacgacaga aatagcaatc tcaggattgt cagctggtgc ataagccaca agcgtcgtat 2284981 tataagtgtc tgttcctgtt tttgatttat ccggtccgtc gtaaaatgat tgggctgttc 2285041 ctgtttttgc agctggttta tacgatgctg aagccagttg acctgcagct gtccctttag 2285101 tggcaacccg tctaaaaccg gcttggacct cttcaatata gctactcttc atatcgactt 2285161 tattcaatac ttcaggctga acagaatcaa cgactgcgcc gatccctttt ttcgcatttg 2285221 aatctctgac ttcctttaca agctgaggct tcatgcggta gccaccattt gctatggtgg 2285281 agacatattg agccaattcc agcggtgtat aagtatcata ctgtccaatg gcgaaatcaa 2285341 gcaagaaacc agataatctg cttgtacctt tatatcccgt catttcattt ggtagatcaa 2285401 ttcctgtttt tactcctaat ccaaattgac tgaaataatt tctgaaggta tcaaatgcag 2285461 aagtatccaa aggcaatgct tggtgaggtt tatattcacc tttaccaact gcaattgctg 2285521 ttttaaacat aaaaacgttt gatgacttct ctaatgcagt ttgaatacca accggcccta 2285581 agttttgcca agattttttc cctcttttat cctggccgat atacaatggt tcatccttaa 2285641 atacagtatt caaattaatc gctccagttt gaagaccggt caaaacggtt gcacctttta 2285701 cagctgatcc catagcgtag gatgaagtca tggctcctaa tgcataatca tcaaacttat 2285761 aggctccatt ttctcgttta atctgcttcc ctgccattgt cagcacttcg ccgtttctag 2285821 ggtccatcat gacaacgaat gcacgatcca acaattcggt actaggtctt gctttagcag 2285881 ctttaagttt tttctcaata attttttcca ctgatttttg caaatcaata tcaattgtta 2285941 gtacaagatc tttcccggct ttgccttcag ataccgtttt tgttcccgtg acattgcctt 2286001 ttgaatctgt gatattttcg acttttgctt tttggccctg cagaaggctt tcatattggt 2286061 attccagata gctttttccg accctgtcat ttcggctgta gccaagcgac agataatggt 2286121 cgagcaagtt ggacggcaat ccttcattag agctggaaac acttccgagc actgagcgaa 2286181 gaaggttttt ataaggatat tcacgttccc aatcggacgt gacatcaaca cctggcagtt 2286241 cgtctaaatg ttcacttacc actgccattt ccttcgctga tacatcttcg tttttgatat 2286301 attgaggggt caatgcatag cccgaatcca tctgtctttt gatagcaagg atctgcatat 2286361 ctttatccgt caattcattc agctgcttat cagtaatccg ttttagctga agctggtata 2286421 aatcgtcatc ggatattttt ttgtcttcaa cctgctgtct ttctttagag ctaatgagct 2286481 ttttcgcttc tttcggtcta gtcaaaatcc aataatcttt tttatcccgt tctgttactt 2286541 tttttgtatc gactttgatc atgtcagaca gcttttttgc gatctttaag cgctgttctt 2286601 gcgtggtcga tttagatctc gtgtatgtga ttgcatttaa agccttattt gtcacaatgg 2286661 cattaaagtt tcgatcataa attttcccgc gtggtaccgc tgagctgact tcactttgtt 2286721 cctgcttatt cgcttggttt ttgtaatcat caccttgcac gatctgcttg atgcccagtt 2286781 ccacaataat ccaggtaaat ataacaaagg cagctaaaaa taaaatattc agccggatcg 2286841 gaagcgactt ctttttctct ttatgatttt gcttttttgg tttatttctc ctcataacat 2286901 caccttttct atttacagaa agaaaagaca ctcaagtaag agtgccagtt ttcattttaa 2286961 aggttttttc gacttttttc tacagataac ccctttttgg caaaaaaatt atctctcgcc 2287021 ttttaaaagg gtcggttctg ttacccgttt ttggccgtct tcttccatgg tttcattttc 2287081 cccttctttc tccttaaaac gaatatcctt gacaaagtaa taaatcaaag gatgtcctat 2287141 acccaatatc gcaagtgaca aaggaattcc cacatcctct ttcagaaggg ccacaatcag 2287201 gagaaagcac aaaatggaaa caattctgcc ggcgttcaag aacatttctc taagcacgat 2287261 atattcaatt cttgcttttc tggcatgcct cgcgcgccct atcacatcat atgtaagtga 2287321 tacatatggc acaagcaaca gaggatagcc gatggcaata aaaacgccgt acgttaataa 2287381 tgtcgaaaag ctcatatgga acagaatcaa aaacagcgcg ccatacaaaa taagtccgcc 2287441 cagcaaaatc gatttttttc tcgccttttt cttaatcagc ctggatgcaa agtagtaggc 2287501 aaagaaggaa acagctgaat tgacaagacc gaatgtaccg agagcaagct cgctgtttgt 2287561 ctcaataaat acaaacacac tgattaaaaa gacaaaaatc ccttctctca aaccctgaaa 2287621 aaaatgcgca ttcgtgattc tccgccaatt catattgcta tggcgctctc caaatacttt 2287681 gctcagcata aaacggccct ttgattctct ccgttttaag aaaaagctca tcacgacagc 2287741 cagggcaaat aaactgaggg agagactgaa aatcactgta taacccgtat tattttcaag 2287801 ccttgagatc acgaatccgg ctacaatcgg gccgatcatt cctgcagagg aagacagaat 2287861 gcccataaac ccgttgaaaa agtctcgtgt atccggctct gttatttcaa aggtcagcac 2287921 gttaaacgct agccaataaa agccatagcc aactccgagc accgcgccga ttagcacgag 2287981 gcggctggcc gccgtttctc cggctaaaag cacacttaaa taaaaggcag ctaaaaaaat 2288041 gacgccgaac cttaaaatga ataccctgtc tatttttttg gctaaccgtc cagccaaata 2288101 aaaggttatc ggctgcattg tcacaatgga taaattatat atcgccaaat caataaattt 2288161 ccctgactgc ttccaaagat acacattaac aaatgtattg gacagtgcaa ttcccagcga 2288221 gtaaagcccg ccaatggtca gcagaaagag taagcctttg tttacgtcta catcgcctat 2288281 cacttttttt agtttgctca ttactgactc ccctttacta tcccttagtc tgtctcactc 2288341 aaaccgagat atgtaaaaag aagacataaa aaaacaaggt cccataatga ggaccttgtt 2288401 tgtgccatta ttttgcttcg ctgtatagac gagccacttc gtcccagttt acaacattcc 2288461 agaaagctga aatgtaatca ggacggcggt tttgatagtt aaggtagtaa gcatgctccc 2288521 aaacgtcaag acctaagata ggcgttttgc cttctgaaag cggagaatct tggtttggcg 2288581 tgcttgtgat ttcaagttta ccgttgttca caacaagcca tgcccagcca gaaccgaagc 2288641 gtccagctgc tgctgctgcg aattgctctt tgaatttgtc aaagcttcca aatacactgt 2288701 taatctcttc agcaagcgcg ccagtcggtt cgcctccgcc gtttggagat aaaagtgtcc 2288761 agaataattt gtggttcgcg tgtccgccgc cgttgttgcg gactgcagtg cggatgtttt 2288821 caggaacaga atcaagatct gcaacaagct cttcaactga tttgttggca agagcagtgt 2288881 ttccttcaac cgctttgttt aaatttgtca cgtatgtgtt gtggtgtttc gtatggtgaa 2288941 tagtcatagt ttccttgtcg atatgcggtt ctaaagcatc gtacgcataa ggtaattctg 2289001 gaagttcgta agccatgata attcctcctt agtatatatg tactgaaatg ccgcttcaca 2289061 gcgagccttt cttcattcaa tgtaacaaaa gaatgctttg taatcaatga aaaagctcac 2289121 gatttggctc atttcagcgg acatatttca ctttaaccga taatctgccc cattaaacct 2289181 gccgccagca tttcttatag gaccgtccat aaaaagtaac cgatcatcaa aagctgtatg 2289241 atgccctttg caataacccc tgttaaaaaa ccaatgagtg agccgaggcc aattttaaac 2289301 gctgacttta agtccttctg atggacgata agttctgcgc aaacagcccc gataaacggc 2289361 cccaatatga tccctgcaac cggaatgaca aaaggcccga ttaataaacc gatcgtgctt 2289421 ccccatatgg cagctttgct tcctccgaac ctttttactc caagcagatt cgacacgtaa 2289481 tctgctgcga ataatactgc ggcaaaaact gcctcaacaa gccagaacat ataagaatac 2289541 ggactgaatg aaaataaaaa tccgtacaat acaaatccgg caacaataaa tactacgcta 2289601 ggaataacag gatacaccag cccgataaag gcaatgataa aaaccgctgc aatcaacagc 2289661 caatacaaca tatccatagc ttccatcctc ccattttact ctgtcttctt catgtcttcc 2289721 ttgtattcac acgcatgcaa cgatacaata agcaacatat attagtttag ctaggaagtg 2289781 aagatagtga atgtgtttca gcttttcatt aaaagtacat actctccccg tgatattgca 2289841 aaaacaagat ttcaaggaat cggaaaagcg attctttatg tatttttgct ctctgtcctg 2289901 tttgcaatcc ctaccgctta ttatgtaagt acagggaccg taaaatcaat gaacggcttt 2289961 aaaactgttt taaacaaaga tttccctgat ttcacaattt caaacggcaa acttcaaacg 2290021 gatgagaaaa aagccacgga atctcaggca aatggtttcg ttatcgtgtt cgatccgaca 2290081 gactcctatg gcactgaaca aattgaagca aagcaaaacg caatcggcat ccttcagaac 2290141 aaatttgttt tggccattga cggacaagcc caagaaatgt cttactcaat gatgccgtca 2290201 gagttacaga aaaaagatgt cattgcaggt ttaaaccaaa ataaagcgat gattgtaact 2290261 gttctctcag ctcttatttt tctcgtaaca gcagcgggaa aatttattga agtatcgttt 2290321 ttagcgctta tcgggttaat cattaagaat tcgcagaaaa aacatttatc ctatcatcag 2290381 ctctggaagc tttctgctta ttccatcaca ctttcaactg tattctttac aatcatgcgg 2290441 gcactagaag caaccgtacc aagtgaattt ttgctgaact ggtttgtcaa ttttgtcatc 2290501 ctgtttctcg ttttaaaaga gattccgtcc aaaaaagtaa ttaataaaag ttaaattata 2290561 tttattttta tcctttaagt agagagtgtg aaagcatttg cattaacttt ttacttaagg 2290621 gatatttaat aaaatgtata gagcttaaac agatacattt ataaaaaaag ctctacaatt 2290681 actcaagaac aagctctgga caataatatc agaagtagta agatgtaaca tgaaagaagt 2290741 tcttaacagc atttgacata tgtttttaac aaaataagaa taatgttaaa ttttaactaa 2290801 tagactagtt aaaatcatat ggcaaaatat tttgcatcct ttcacaacat atttacataa 2290861 gatagttgct atttaaaaag ccaggtacca atagggcacc tagctttcag aattaaatca 2290921 tcaacaagtt agaattatct tctttccttc tattctcatt attgaactgt tatctttttt 2290981 gtgggtttat gtatacaaat gcagctccct tagctttccc cttatatact gataaaccta 2291041 ctgcccaagg tgttcctgtc ggttttggta atttactgaa gtaaaacttt ttggttggag 2291101 ttctacttga aaagtaccct gaatattgcg ggccaatgtc cccaccctca actatagata 2291161 caccaaagct cttataattt agtttaccgc attttccatt tgtttcggcg taagcatcaa 2291221 tagatgttgc actcttagta tatgtataag catctgtaat aactcttatt ttacaaccag 2291281 aaataccact taccggttgc caaccactgc ttgcagcctc tgctttttct ttaggtgcaa 2291341 ctaccaaagt taacattagt agcaaaatta aaaacacaga aaattttcct tgcttcattt 2291401 tgtagatcct cctttaaact attacataat tatcctaaca gatccattgt tcattgtaaa 2291461 taatggaata cgagttttat attataaaag cctctttttg atctaatttt gcactatttt 2291521 ctattttcta tctgaagtta atgtttagtc gaagaaatcc tgtcaaaaaa gcgcctgtat 2291581 aaaaaccgag cattcgcagt ctcttttctt ttgtcatgaa tcgaaatgga caagcatact 2291641 atggtataaa atttcgtatg cgggaggaaa agcgatgaag cgtctcacct tagtatgcag 2291701 cattgttttt atacttttta ttctttttta tgaccttaaa attggaacca tacccattca 2291761 ggacctccct gtctatgaag catcagcaaa aacggctgta caagaaccgg cttataaaac 2291821 ggtgaaggta aagccgggtg atacggttat gtcgatagtc ggatcagcag gttctccgga 2291881 tgacattgta aaggattttg aagcactgaa tccaaatgtg aaagctaacg ccattcaagc 2291941 cggaacagcg tataaattcc cggtctaccc ttaatttaac gttaatttct tgtcagttcg 2292001 gcgaagacac tgttacaatg taatttgtaa aataaattca cataaaccat actagaattg 2292061 ttatatctag aagcggcaac tacaattaag gagcgattgc aagtgagtga aatcacacat 2292121 cgtacaaaaa cgcgtcccgt caaagtggga cctttaacaa taggcggcaa caatgaagtt 2292181 gtcatccaaa gcatgacaac aacaaaaaca catgatgtag aagcaacggt tgcggaaatt 2292241 aaccgtttgg ctgaagccgg atgccaaatc gttcgggtag catgtccgga tgaacgggcg 2292301 gcaaacgcca ttgcggatat taaaaagcgc atttccattc ctctcgttgt tgacatacat 2292361 ttcgattata aacttgcgtt gaaagccatt gaaggcggcg cagataaaat ccgaatcaac 2292421 cccggcaata tcggccggcg cgaaaaagtt gaagcggttg ttaaagcggc caaagacaaa 2292481 ggcattccga tcagaatcgg agtaaacgcc ggttcattgg aaaaacggat tttagaaaaa 2292541 tacggttatc cgactgccga tggaatggta gaaagcgcac ttcatcacat taaaattctt 2292601 gaggatcttg attttcacga tattattgtc agcatgaagg cctctgacgt gaaccttgca 2292661 atcgaggctt atgaaaaagc agcgaaagcg tttgactacc cgcttcacct cgggatcacc 2292721 gagtcaggaa cactgtttgc cggcacagta aagagcgcag caggactcgg cgccatttta 2292781 agcaaaggca tcgggaacac catgcgcatt tcactaagcg cagaccctgt agaagaggta 2292841 aaagtagcaa gggagcttct gaaatctttc ggcttagcct ccaatgctgc cacgctcatc 2292901 tcatgcccga cttgcggccg tattgagatt gatctaatca gcattgccaa tgaagtggaa 2292961 gagtatattt ctaagataaa agcgccgatt aaagttgctg ttctcggctg cgctgtaaac 2293021 ggacctggtg aagcgagaga agctgatatc ggaatcgccg gcgcacgcgg tgaagggctg 2293081 ctgttccgga aagggaaaat tgtccgtaag gttccagagg aaacgatggt agaagaactc 2293141 aaaaaagaaa ttgacattct tgctgaggaa cactacgcaa aacttgaagc tgaaaaagca 2293201 aaattaaaag aagaaacaca aaaagcttga cgggaacccg tcaagctttt ttgtgttaga 2293261 aaaatggaat aataaatatt ccaagcacta atgaaacgac accgataccc attgcccagg 2293321 ctccaaggcc ttgagcacct cttcttcttg cgatatagcc gacaataata ccagcagctc 2293381 ccaataaaac aggcagtaca aacaatgaaa tgatggacaa ggctaaagcg atgtacccta 2293441 ttccccgtcc ttcattgaca ttgccgccgc tgcgatcatt gtcttggtca ttgctgcggt 2293501 cagcagcacg ataaggctct gcgatttcag cagctgtttc ctcaaaaaaa ccgtcattgt 2293561 cgcgggtaat atttgtccct tcagatccat gatcaacata gtaactgttg ttatcacgct 2293621 tttcgtaatc gtttgccacc ttcaattccc ccttctgttt tattaaagga gcttttatag 2293681 tttgatccat tttgcctgat tcatgtttgc taaacttttc tgttaatgtc aattgtttat 2293741 gttacacttg aagggatgaa actgaaggag tgtgggcatg ttacgcttag gaatagatat 2293801 tgacggcaca atcacggctc aggatacatt cgtcccttat ttgaaccgtt cgtttaatct 2293861 ttccatttca ttaaacgata tgacggatta tgatttaaca aagctgttaa acattaccca 2293921 ggaagaattt tgggattgga tgaatcaaaa tgaagcgatc atatataagg aagcattgct 2293981 tgcacagcat gcgaaacagt ctctcgatct tctcaaagag gagcacaagc ttatttatat 2294041 tacagcgaga cggactcatt taactgatat tacttatgaa tggtttgaca gacaaaacat 2294101 tcattatgac cacatcgaac ttgttggggg tcatcacaaa gttgaagcgg tcaagaatca 2294161 taacatcgac ctgttttttg aggatcatca cgggaacgcc atgatgattg cgaaagaagc 2294221 cgggataccg gtgattttgt tcaattcccc ttataatcag cttccgattg attcaaacat 2294281 catcagagta aacaactggc tagaagccgt tcaatggatg aacaacaaca agcatcactt 2294341 aatacgcgtc aataactgaa aaaggagccc aaaccgggcc cctttttcat atatacgcat 2294401 tttacgcagt agtgttttct tggttttccg ctgtacaatc agggcatgtg ccataaatct 2294461 caaatttatg cccgctgacc tgatagccat ccaaatcatc acaaagcttg tccatcggac 2294521 atgattcaat ttcctttgtt ttgccgcagg caagacaaat aaaatgatgg tggtgatggg 2294581 tgaatgaaca cttaaatcgg aagagctttt caccggacag ctcagttgtt tccaaaatcc 2294641 caagttcttc atataaagaa agatttctgt agattgtatc aaagcttaag cctggataat 2294701 catcattcag tgcagacagt acgtttttag cggtaagata tctgtctgaa tcagcaaaaa 2294761 gctgcagcat atcctcccgt ttgtttgtat atttatatcc gttttctttt aataggttca 2294821 gcgcttcttg gacgttcatg aagggtcccc cttttcgctt tgcttaagaa cgtatcacat 2294881 gtatgaaaaa gaaaatggca gctgtctgtc cagcaagcca ttttctttac tgcagataaa 2294941 attataccca taaaatgaat aaaagtaaat gaaagcctag tggattgcgt ttttgaattt 2295001 tccgcctctc gtttcatgag tattcataat tgttatgaat gcattttgat caacttcaaa 2295061 cacgatcgat ttgagctttg tcacttccag ccttgtgaca accgcgtaaa ttacgtcttt 2295121 ttcttcgtcc gtatacccgc ctttcccctt cagcttcgtt gtgccccgac cgagacggtg 2295181 caaaatcgcg tcggaaatct catcatactg ctcagacaca ataatgacag cttttgtttc 2295241 atcaagccct tggatcacgg catcaatcgt tttcatcgca atataataag tcatgaatga 2295301 gtacatcgct tgctcaggac cgaacacaaa aactgcccaa atgaaaatga acacattgat 2295361 gaacataacg aactcaccta cagaaaacgg gagttttttg gtcagcaaaa taccgagaat 2295421 ttctgtacca tccattgaac ctccatttcg aataacaagc ccgacgccaa agccgagtaa 2295481 aagacctccg aacacagtag ccaaaatagg ctgggttgta atggcttcta catggtgaag 2295541 tgaggattca ataacggcaa gcccgacaat ccctataaac gtagagacta gaaaggtctt 2295601 accgatatat ttatatccga agatcataaa aggaatattt aatatgacaa cgaaaaaagc 2295661 gaaattcaga aaggggtttg acataaagag gtggtctaaa ataagagata caccgataat 2295721 cccgccatca ataaaatcat tggggattaa aaataattca atacttacag ccgcagatgc 2295781 agctcctacc agaatcataa agaccctgaa aataaaatgg gtaaatgttt ctttcttatg 2295841 ttgttttgtt ggggtcataa aatctccttt cctgcaataa ctattttaaa tacattataa 2295901 atctatttta ccattaaaca ctgacacatt ttactgattt gcccatacat taagtctgga 2295961 ggtggaatga ccgatgattt tatttcaaag aattattttg cagcggctta atcaggctac 2296021 tgctgatgat ttgctgaagt actcaaaaca atacggaatc agcttaacaa gatcgcaggc 2296081 cgttgaagta gcgaacctgt tatacgggaa aaatgtaaac atctttaatg agagtgaacg 2296141 aatgcggctg ctgaaacaag tagagacgat tacatcgaaa gaaacagctc aaacagttaa 2296201 tgaactattc aaacaattta caagctaaaa aatgggggtg ttatccccca ttttttattg 2296261 ctgtaaaatc ttttcaagca atgtatcatc aaattgtttt tctttcagca tttcaatctc 2296321 aaaacggtat ggcggttttt tgttcttttt atcttcaccg acgtatggtg tttcaagaat 2296381 ttttggaatg tcttttaact gctcatggtg aacaacatat tgcagtgcgt caaaacctat 2296441 ttcaccaaag ccaatatttt catggcggtc ttttctcgca cctttgacat ttttgctgtc 2296501 attgatatga agcactttaa tacggtcaat gccaatgatt ttatcgaact catttagcac 2296561 tccgtcaaag tcttcgacaa tgttataccc ggcatcatgt gtatggcacg tgtcaaagca 2296621 cactgacagc tgctcattgt gtgtaacgcc ttcgataatc tgcgcaagct cctcaaagct 2296681 tctgccgcat tctgatcctt ttccagccat tgtttctaat gcaatctgga cattttgatt 2296741 cggatcaatc acttcattta agccttcaat aatttttttg atgccggctt cagctcctgc 2296801 ccctacgtga gcgccaggat gaaggacaat ttgcttcgct ccgatggccg ctgtccgttc 2296861 aatttctgaa cgaagaaaat caacacccag ctcaaaagtg gacggatttg tcgtgttgcc 2296921 aatattaata atataaggcg cgtgtacgat aatctcgtca atgccgtttt cttgcatatg 2296981 tgcccggcct gcttctatat ttaagtcttc aattttcttt cggcgcgtat tttgcggtgc 2297041 gcctgtatag atcataaacg tattcgcccc ataagagact gcttcctggc ttgcagccag 2297101 aagcatatgt tttccgctca tagagacgtg tgagcctatt ctcagcaaca ggttccccta 2297161 ctttcttttc ttagattggt ttcttctctg ttttttcttg attttctcca tctcatagct 2297221 cattttcttt ttatacccag gcttaacctt cttcggcttt ttcacgagac gatgagcaat 2297281 ttcatccgct tcattcggcg tttttttacg ttttttgcgg cgctgacggt catcgccttt 2297341 tttccattcg cccttttcaa gctctaagta ctcaaattcg atgcccattt tttcaagtct 2297401 tactaatgca tcctcatcag taagctcata aatggtcatc gcttgtcctg atgagccggc 2297461 acgagccgtt ctgcccacac ggtgaacata gaaatcgaga tcatccggca gctcatagtt 2297521 gataacatgg ctgacacctt taatatcaat acctcttgcg gcaaggtcag ttgcaatgat 2297581 atatgtgaat tccaaatcat tgatctgctt catgactttt ttccgctcac gtggtgttaa 2297641 tccgccgtgc agcaagccga ttttcatgcc tttgccagtc agatactggg caatatggtc 2297701 agccgtattt ttcgtgttgg caaacacaat ccccaggtat ggattcagat gcgacatgat 2297761 gtcaaaaagg agcttgtcct tgtcacgatg tttcgaagga atgaggatat gctcgatttt 2297821 cgcagcagtc acctgttttg gctccacatg ggcgtatttc ggattttcca tgtatttctt 2297881 caagaatggt ttcagctttt ccggtatggt cgctgagaac acaagcattt gcagatcctc 2297941 aggcatgcgg gaaccgatgt aatctacatc tgcaaggaat cccatgtcca gcattaaatc 2298001 cgcttcatca ataacaagag attccgcttt atgaacactt aacgcctgtt ctttgattaa 2298061 gtcagcaatc cgtccaggtg taccgacaac aagatgcggc tgtattttca atttatcaat 2298121 tgatttttgt ttatcagtgc ctccgataaa acatttcgag cgaatctgac ttccttcttc 2298181 accctgcgtg attttaagcg cttcctgata aatctggttg gcaagctctc ttgtcggagc 2298241 cgtaatgact acctgaacga catccttagc aggatcgatt ttgtttaata aaggcagtaa 2298301 ataagcgtga gtctttccag tacccgtctg agactggccg atgacgcttt ctttttttaa 2298361 cactgcagga atcagccttt tctggatatc agtcggttcg taaaaaccaa ggcgatgtac 2298421 tgcatctata ataaatggtt tcaattcata aagttcaaat ttcgtttctt tcatttttcc 2298481 cagctcctta aagcggcaca ttatgtgtcc atcatcacat tatacccgat tttgcttaaa 2298541 aacaccacgt ttgcaaggcg tttgttttat tcagttatgt aaagcaaata ccgcagccca 2298601 tgcatattct aatagcagag agagctgaaa ggaggtacaa gtatgttttc accgcagcag 2298661 ccaatgagaa attacccaca gcccggaccg ccccgcccca tgccaaatca gcgaatgatg 2298721 ggcagaagac cgcctaatat gcgaggacct tcatttggag cacagcagca aggttttcag 2298781 caagccggac aatttcttcc tcaggcaaat gccggagcga gaaatggtgc aggtgcaggc 2298841 ggaggcttaa aaggaatgct gtcaaggttc ctccccggcg gaggaggcgc tggcagcgcc 2298901 ggggttcccg gaattccagg agcaggtgca gcagcgagcg gaggtgctgg cctgcaaggc 2298961 attcaaaata ttgccaatcc tgcatcatta tccagtatgc ttggaaatgt gcaaaaagta 2299021 ctcggcatgg cgcagcaagt cacccctatg atccagcagt acggcccatt agtccgcaat 2299081 ctgccagcaa tgatgaagct gtacagccaa ttaagtaaaa gtgatgatac tgagacagag 2299141 gccaatgagg aaagtgaaaa acaatccgtt tcagaagaat catcagaaaa agaaaaagag 2299201 actgaaacaa aaacctcaga tgggaacaaa aaatcaaaac caaaaagttc ttctctccca 2299261 aagaaatcta aaacaactga caataaagaa caagaattaa aaacatctgc cccgaagaaa 2299321 aaggaagctg cctctcctgc tccgaaaaga acatcaggca gttcaaaacc gagattatat 2299381 atttaacatt ctttgatatc ttaagtgaga ttggctataa tgagatcaga agaatgcaag 2299441 aatagagccg tttgattacg gctttttata ttgcctttac tcacttcagt attggaggac 2299501 aaccgaaaat ggacgtaatt aaaatttcac cgcgcggcta ttgctatggt gttgttgatg 2299561 ctatggtcat tgccaaaaat gcgtcgctag ataaaagctt gccaagaccc atctatatac 2299621 tcgggatgat tgttcataat aaacacgtca ctgatgcgtt tgaagaggaa gggattttta 2299681 cattggacgg ctctaaccgt ctggacatct taaagcaggt tgacaaagga actgtcattt 2299741 tcactgcgca cggtgtttct cccgaagtca gaagaatcgc agaagaaaaa gggttagtcg 2299801 caattgatgc tacatgtccg gatgtgacaa aaactcataa tctaatctta gagatgaaag 2299861 aaaaaggata tcacgtgatc tatatcggca aaaaagggca tccagagcct gagggagccg 2299921 ttggcgtagc gccggagatc gttcacttag ttgaaacaga agaagatgta aagaaccttg 2299981 atatccaatc tgagaagtta atcgtgacga atcaaacaac aatgtctcaa tgggatgttc 2300041 acgacattat ggagcttgtc aaagaaaaat atcctcatgt cgaatatcac caagagattt 2300101 gcctcgctac tcaagtgcgg caggaagctg tatcagagca ggcaaaaaaa gcggacttaa 2300161 caatcgttgt cggagacccg aaaagcaaca attcaaatag gcttgctcaa gtgtcagagg 2300221 aaatagccgg gacaaaagca taccggatcg gcgacttaag cgaattgaag ctcgaatggc 2300281 tgaaaggcgt taataccgtt gcagttacag cgggagcttc aacaccgacg ccgatcacaa 2300341 aagaagtcat tcgcttttta gagcagtttg atcacgaaga tccatcaact tggacaactg 2300401 aacataatat accgctcaaa aaaatacttc caaaagtaaa agcaaaaaac tgaggctgta 2300461 aaagcctcag tttttttata gaaatgtaaa tggatttgta tctgtttcag aaacaaagat 2300521 attcacgcca aactttttat cattacacat tgatgtaagt tttctcgtga cgccttcttt 2300581 catgattttt tccgcgtaat ggcccggatc aaccacattt aggccaagca tcatcgcatc 2300641 atgggccaca tggaagtata aatctcctgt gacgtaaaca tcggctccct ttcgttttgc 2300701 atgatgaata tacttgtttc catctccgcc aagaacagct acttttttca ccatgctgtc 2300761 agcatcccca accattctga caccattgac gtcaagcttg tctttcacaa ataaagcgaa 2300821 ttccttgagc gtcatctcat ttttaagggt tccgacacgg ccgagccctt tttcggcggg 2300881 agtctgttcg acaggataga tatcgtaagc gacttcttca tatggatggc tttttatcat 2300941 tgcattgata acagcctttt cgacgctttt aggaaataca gtctcaagcc ttacttcatg 2301001 aacaagctca agctctccca cttcaccgat aaaaggctta gctccgtcca atggcttaaa 2301061 gctgccgatt ccttcagatg aaaacgcgca atggctgtat tcaccgatat ggccggcccc 2301121 cgcatttccg agcgcggctc tgacctgctc ttcatattcc ttcggcacgt aaactgccag 2301181 ctttttcaga ggatccgtat aagtaggtgc cagcacttcc gtctcactca gctctaatgc 2301241 ttcagcaagc aaatcattca caccgccgtc cgcaacgtct aaatttgtat gagctgcata 2301301 aacagcaata tcatgcttca aacacttttc aattaacctt ccggcaggct gatctgttga 2301361 aatatgcttt agcgaccgga aaattggtgg atggtgtgca ataatcaagt caacctcttt 2301421 ttcaatcgct tcatcgataa cgctctctaa cacatcaagt gtaaccatca catttttaat 2301481 tggtttgttt aaggtgccga tttgcaggcc gattttatct ccttcaaccg cataggcttt 2301541 cggggaaaat tgttcaaaca gctggatgat ctgctgccca tttacacttt tagccatgat 2301601 cgattacctc ctttaacagc tccattcgat cggcgagctc ctttaatttt tgtttgtttt 2301661 gctctgtatc cgccgcttgg ctgatctgtt cataaatgct ttgagtgtgc tgaagctctt 2301721 gtgtccactt tttcaaaaag acagcatttt tttcttttgc caagaaaggg ccaacgagca 2301781 tcccggctga taaagaaata ccgtcataag ccgcatccct gtctcccgct tctgccacca 2301841 gcacctcata gcactttccg tcctcttcaa ggattacctc atctatcagc gcatatcttt 2301901 ctttataaag ccactccctg atatgaacag catgaatatt cggctgtaaa atgagccgtt 2301961 ccttccccgt taatttgtct ttgcccgctt ctaaaatgtg agcgatcaaa gccccgccca 2302021 ttccggcaat cgtaatggca tcagcttcac cttttttaat cacttccagt ccgtctccct 2302081 gccttacaga aatgtgcgag tttaagcctg atttttcaac ctgccgcttt gcagacaaaa 2302141 atgggccgtc tgttatttct ccggcaatcg ccccgctggc tttatgattc agcaccgcat 2302201 aacaaggaag gtaggcgtgg tcagagccga tatcggccat caccgctcca ttcggtatgt 2302261 actccgctac tgtttgcaat cgtttagata attttaattc gttcacttgt catcacaact 2302321 tttctcaatc attttttcct ttactatcat ataaaaaatc agcccggaat ccaagctgaa 2302381 gcaaatgatt ttgaaattat ttcttttgat gcgggtctgc acgcagcagt caaaaataaa 2302441 aggctgtcga gaacatctcg gcggcctgtg aatgtataaa gagaaaaata gttcttttat 2302501 ttaatttttg acacccactc tgccatatca tccagcttat cggccggaac aagaccggaa 2302561 ggcattccat taccgccttt ttcgatcttt gttttaattt cagcgacatc tttcttatcc 2302621 cctacacctt ttaagctagg acccgaaaca ccttcataat tttcaccgtg gcatgcgatg 2302681 cagtttgcct tgtaaatttc ttctggtgaa gcgtttgcat ctttcttttc agcagatttg 2302741 ctttctcctc cgctcgcaat ctcccgagag tcatcaagtc cttttactga taaaaagaaa 2302801 gttagaccaa ttcctaaaac agcgatcagc aaaaatggaa taagcgggtt ccatttcatt 2302861 tcccttcccc ctttttgatc cttcccccta tgtaaacact tctaattcta acttattttt 2302921 acaaaaagta aatggattgc tatacaaaag ttttttattc acactttata caaaattgaa 2302981 tagaaacatg cctaaatctc taatatcctt tttattctat tgtataatgt attgtatacg 2303041 cttacaatag aaaatatgga attagatttt gaaatttttc accacaatgt tcatttgcaa 2303101 atgacatcat ttttcagtaa aataaaggca tattatccat atatcttttt aaaaaaagaa 2303161 gaacggatct tcaagacccg ttccatctta ttcaaggaaa tctttcaaac gtttacttct 2303221 gctaggatgt cttagtttcc gcaacgcttt ggcttcgatt tgtcgaatac gctctctcgt 2303281 tactccaaat actttgccga cctcttctaa tgttcttgta cggccgtcat caagaccgaa 2303341 tcgaagacgc aatacatttt cttcacgatc agttaacgta tcaagcacat cttccagctg 2303401 ctctttcaat agctcgtatg cggcgtggtc agaaggtgaa gttgcttctt ggtcttcaat 2303461 gaaatcacca aggtgcgagt catcctcttc accgatcggt gtttccagag ataccggctc 2303521 ttgagcaatc tttaagattt cgcgtacttt ttcaggcgtt aaatccatat cttccgcaat 2303581 ttcttcaggt gttggttctc tgcctaagtc ttgcagtaat tgacgctgca cacggattaa 2303641 tttattaatg gtttcaacca tatgaacggg aatccggatc gttctcgcct gatcggcaat 2303701 ggcgcgtgta atcgcctgtc tgatccacca cgtagcatac gtactgaatt tataaccttt 2303761 gcgataatca aatttttcaa cggctttcat caggcccatg tttccttcct ggatcagatc 2303821 aaggaacagc ataccgcgtc cgacataccg ttttgcgata ctgacaacaa gccgcaggtt 2303881 cgcttcagcc aatctgcgtt tagattcttc gtcaccttct tcaatctttt gagcgtaggc 2303941 gatttcttct tttgcagaaa gaaggttaac ccgaccgatt tcctttaaat acatacgaac 2304001 tgggtcattg attttaacgc caggcggtac acttaggtca ttaaggtcaa attcttcttc 2304061 ggctttggca agctgctgaa tattaggatc ttctgtttct tcattctcac taattaattc 2304121 aacaccttgt tcacctaaaa attcataata ctcatccatt tggtctgatt caatttcaaa 2304181 gctggacata cgctcagcaa tttcttcata tgtcaaaacg ccacgttttt taccagactc 2304241 tgttaattgc tcttttactt ggtcgaatgt taattctgtc tcgtgggttt gtttatcagc 2304301 cattatggat ccctccttcc aaagcttgca acgaattcta taagcggtat gattcttatt 2304361 cggtccattc aggcgttttc tatgtgaact gcctttaaca atgtgcgaat aatgaaatga 2304421 caattcatga tgaggttaag cgatctattt gctcctccgc aaggaatcat tgccaataaa 2304481 tgctcctcat cagttctcca gttattttaa agatcggttc aatgtaacga tttcttgagc 2304541 caaagaagca gctcttaaaa aatctttttg cctttctgct tcggctcttt ccgcctcttt 2304601 ttcttttatc attgaccaat ttctttgatt caacactttt tttacataat ctgataactc 2304661 ggcttcgcta agctcttgat taacctgaag cattaatata tcggacaaga gctggcttat 2304721 atgatcatcc gtcaccctgg ccatcagatg ctgaggcgtc agctcggctc cctcttcata 2304781 aaaagcataa agataagcgg ctaatgcccg gtgctcatca atattaaatt gaaaccctac 2304841 ccggtcaatc acttttttga tgacgctccg atctcgaagc atgtgagcga gtaacagcct 2304901 ttctgcattt tcatacgccg gacgcaaacg tttttgcctt gcttttgtcg tcagatgcgc 2304961 tcgccgcgtt ttagtttcac cgctattgtc agcaggtttg ttttgcttgc tgaaaacaga 2305021 cagctgctca gttaaagact cctgtgaaag cgaaaactct gaagcaagct gctttacata 2305081 gacttcctgc tctagagacc ctgaaagcgt gctgatttct ttcagtacgt ctttaatgta 2305141 agctaggcgg tcgccttcat cggacaggtt ctttcctttt cggaaatatt gcattttgaa 2305201 cgccattacg gtgacacttg cgtcaataat gtcgttttta aatttttccc cgccgaattt 2305261 tttgatgtaa tcatcagggt ccaatccgtc aggaatcatt gcaactctga ctttgcagcc 2305321 ttttttttgc agaagctccg aagcttttaa ggtggcttca taaccggctt tatcagagtc 2305381 atagcaaaga atgatttctt cgacgtttct tctcaggatc ttgacatgat catctgtaag 2305441 agacgttccc atcgtggcta tgctttcctt tacatccgag cttacggccg atatgacatc 2305501 agcaaaccct tcaaataaga ctgctctttc ctgctttctg atatgaaggc gggccttata 2305561 aaaattgtaa agcagtttgc ttttatgaaa gagcggggtt tcaggactgt tcatatactt 2305621 aggctgctgg ctgccaagag ccctgcctga gaaagcaaca acagccccgt gatgatcatg 2305681 gatcggaaac atgacacggt ttctgaagcg gtcgaaatat ccgcttccgt cttcgcgtct 2305741 gatcaggaga cccgcttttt ccatttgcgc ctcactaaat cccctcttta caaggaattt 2305801 cgtgataaag tcccaagaat caagagcata gccaatctga aattcattaa tcagctcttt 2305861 cgtaaagccc ctagaaagca gataatccag tgcctcttga ccttcttttg tatttattaa 2305921 caaatgatgg taaaatttct tcaggagctc atgtgcctca gccatttttt gttctccaga 2305981 agactctggc cgggctccgg aatggactgt tatatcatct ggaaaatcaa tttggtattt 2306041 gtcagcaagg tgagaaaccg actcggcaaa agaatagcct tccatctgcc ttaaaaaaga 2306101 gaaaacattg ccgcccgctc cgcagccaaa gcaatgaaaa atctgtttgt cgggcgatac 2306161 ggaaaacgaa ggtgtgcttt ctccatgaaa aggacagagt ccaaagtagt ttcggccttg 2306221 cttctttaat tgaacataat cacctatgac ttcaacgata tctgccgact tttgcacctg 2306281 atccacaatt tcatctggta tccgatttcc catcttataa cactccgtcg tacattattc 2306341 gatgctttag tgcaaaatcc cttcatcgtt cgacaggatt ttttgcagca gtgtaataaa 2306401 tcgttctcga tcttctttat tcaatttttt aggccctttg gcatatacgc cttttcttct 2306461 ttgtttgccg gaaaaatgac ggccctctag ggcaaaatca atcgtgtctt ccttgtaaag 2306521 acgacctctt tccgacataa cagagacatt tctgttcaac agcagagatg ctaatccgat 2306581 gtcctgcgtc acaacaatat ctcccggttt cacgtgattt gcgatatata aatcagcagc 2306641 ttctttatga ggatcaacat acttccattt ttcttcattg cttctggaaa gctgataatg 2306701 ttcaaatgaa gcgacaaaaa gaacttgaac ttcatactcg gatgctgttt gtaaaatttc 2306761 atcttttacc ggacaagcat cagcatcgac aaaaatcgtc ttttcttgtt cattaagaag 2306821 agtaattctc catccctcca ttaaactcct gcataaaagc aagcaaaatc gcacatcctt 2306881 tattattgtg gatgtatatg aatttgtcga aaaatttccg ggagaaattc ttgacatctt 2306941 acccataata gtttattcgt atcacacgat ccttaaacct aaaattaatc attttatcac 2307001 aattttttat tataatacaa acttcacaaa gatgctattg tttttcatta ttcccttttg 2307061 gcacagccaa aaacccagga tagagcgtcc tgagttatat gttttttgtt ttgagatgat 2307121 ggataatatt tgctgtttcc tcaaccgctt tatttgaaac atcaacaacc tggcagccga 2307181 tccgatccac aatcttttcg aaatactcga gttcctcttt gattctgttg atatttgcat 2307241 aaatcgcttt atcattaagc ccgagtgatt ttaaacgttc ttttctgata tgattcagtt 2307301 tatcagggct aatctttaaa ccgatgcatt ttttcggatc aacgttaaag agttcttccg 2307361 gcggatcaac ctccggtaca atcggaacat tggcaacctt caggcgtttg tgtgcgagat 2307421 attgagacag cggtgtttta gacgttcttg acacgccgat caaaacgata tcagctttta 2307481 aaatccctct tggatcacgt ccatcatcgt atttaactgc aaactcgatg gcctccactt 2307541 ttttgaaata atcttcatca agctggcgca cccgccccgg ttcgtatttc gctgttaaac 2307601 cgtaggctgt ttccatttta tcaatcaacg ggccgataat atcataatat aaaacatttg 2307661 ctttttccgc ttcggctatc aaatattctc tgatttccgg caccacgagt gtaaaacaga 2307721 taatgccgcc gtctgccttt gcaagtgaaa tcacttcatt gatagtgcct atatcttcaa 2307781 cataaggaat tcttcttaca tgagtatcat ccgccgatcc gttaaattgg ctgagtgctg 2307841 cttttactac caattcagcc gtttcaccga cggaatccga tacaacatag atgatgcggt 2307901 tattcatatt atccccccgt tagtttgcaa tcttatagga tttcattttc agataaactg 2307961 acaagtattt tggtcatatt tgtttttgtc actctgccga tcacttcaaa gcctttatcg 2308021 gtgtctttga tgacaggcag tgcatcaatt tgtttttcta ttaagtgctt tgcaatgtcc 2308081 atcacataat cctcgcgtct gcacaccgta atgttcggca tccttgtcat gatgatgtga 2308141 acagggaccg atgtaagctc ctgctggcca atgctcgctc tgagcaagtc ttttcgtgaa 2308201 agcaccccga ctaaaacagc atcgcggtcc accacaaaca gagtacctac atcttctaaa 2308261 aacatggtgc aaatcgcatc gtacacagaa acgttttcgt gaatcactac ggggatagat 2308321 tgaaagtctt tcacctgaag ctttttgagt ttatccgcca aaagctgtgt gccggttttt 2308381 cccgtataga aataaccgac tctcgggcgc gcctcgagga atcctgacat ggtgagtatg 2308441 gctaaatccg ggcgcaatgt cgccctggtt aggttcagct tttctgcaat atgctcccct 2308501 gtaatcggcc cgttttcttt tacaatctgc aaaatatgtt cttgccgttt atttagttcg 2308561 atcgtactca ccaccttttc acttcatagc tatgtaaaga aataacaatc catattataa 2308621 cgtaaatatc ttgtaatcaa acaaaaaact tataaatggg gaaaagacga ttaccgatca 2308681 cacagcaacc gccttttctc tctttatttt acaataaggg cattcatatt cgcaaaggac 2308741 ttgatctcat ccgccaagct taccatttgc gctaaacgat ttgcctttaa tgactcatta 2308801 tccgctataa ccattgtatg atcgaagtaa gcatcgatcg gttcttttaa ggctgcaagt 2308861 gaagcaagcg ccgcctcata atcttttttg ctgaagtttt cctgcagatt ttgcttcgct 2308921 gtttggtagg catcaaacag ttttgcttcg tattcatttt caaacagatc aggctgaatg 2308981 tctccgcgga ctcctttttt gctgatagag atcactcggc ctaacgcttc ggctgtttcc 2309041 ttaaagccag gtgcaccaag cttttgctcc agtacttgtg ctttatgcag cgcagagtac 2309101 ggctcaagct cagagctttc cagcacggcg tcaatgacat catgtctgat ttgttcagca 2309161 ttcaagacat atttcaagcg ctgagtgaag aaatccagca gttcattttc tttatcggtt 2309221 tgaacgaaag taagcagctc ttcaaatgaa attccccagt tgcggtcaag aagaatcgca 2309281 acaataccgc ttgcttggcg gcgcagtccg taagggtcct gggaaccggt cggaattacg 2309341 ccgatagaga agaatgaagc gattgtgtca agcttatccg ccattgctac aacagctccg 2309401 gtgaaagtag aaggcgtttc tccgcccgct gatctaggca tataatgttc attaactgcc 2309461 gcagccacag cttcatcttc gccaagcatt ctcgcatact tttcgcccat aattccttga 2309521 agttcaggga attcatatat catatgcgtc acaaggtcga atttagaaat ttcagcagcc 2309581 cgcttcacat gttttaatgt atcttcatca gcctgaagac gaacggcaag tttctctgcg 2309641 attgatgtga ctctcctaac cttatcagca agagaaccaa gctcttcatg gaaaacgata 2309701 ttttcaagct tcttcacatt tgcatcaatg tttagtttct gatcttcttt gtagaagaat 2309761 gaagcatcag ataaacgtgc gcgcagcact ttttcattgc ctcgggccac attttcaatc 2309821 gcgtggctgt tgccgtttcg gactgtgata aagtgaggca gcaggtcacc gtttttgtct 2309881 ttgacaggga agtagcgctg atgctctttc attgtcgtga caagcacttc ttcaggaatt 2309941 gacagaaact cggattcaaa tgaaccgtaa agagctgtcg ggtattctac taaatgattc 2310001 acttcatcaa gaaggtcttc gtcaactgga atgctccaat tgttttcagc agccattgtt 2310061 tccagctgag attgaatcat ttgctttcgg acgctaggat cagcaataac atgctgtcct 2310121 ttgagctgct cttcataagc tgaaggtgat tcaattgaca cttcatgtcc gaggaaacgg 2310181 tgtccctgtg ttgtccgtcc agactcaacg tttgtgatcg aaaatggaat gacatcctgt 2310241 ccaaataatg cgacaatcca tttgatcggt cggatataac gcaaatcttc atttccccag 2310301 cgcatgtttt tcgggaaatg caagcttgta attaaaccgc tcaattctgg cagaagcgac 2310361 ttcgtttctt ggccggcttg gaatttttgc acgaatacat actctatgcc ttttacttct 2310421 ttgatgtaca ggtcttccac atttgcgcct tggccttttg aaaagccgat tgccgctttt 2310481 gtccagttcc cgtccgcatc aagggcaatt tttttcgcag gcccttttgc ttcttctttt 2310541 atatcatcct gcttttctgc gacatcctta acgaacacag caagacgtct cggtgtattg 2310601 aagagtttca cttcaccgtg agtaatattt ttttctttaa gccagcctgt cagcttgtcg 2310661 ccaagctgaa ccatgctttc attcaaaaag cgcgccggca tttcctctaa tccgatctct 2310721 aaaagtaaat cctgtttact catgagaaga accctcccct ttaagcattg ggaaccctag 2310781 tttttctcgt tcctcatagt aggtttttgc tacttttcta gctaaattcc gcactcttgc 2310841 gatatagccc gtccgctcgg taacagagat cgcacctttg gcatcaagca ggttgaaagt 2310901 gtgcgagcat ttcagcacat agtcatatgc tggatgaaca agtccgttgt ccatttgctt 2310961 gatcgcttct ttttcatatg tgctgaacaa ttggaacagc atatcgacgt ctgatgtttc 2311021 aaacgtataa acagaatgct catattcagc catcatgaat aaatctttta ctgtaaaccc 2311081 tgacgtccat tccaagtcaa acacgttttc tttatcctgg atataagacg cgagacgctc 2311141 aattccatac gtaatctcta cagaaacggg tttacactct aatcccccga cctgctggaa 2311201 atacgtaaat tgtgttattt ccattccgtc aagccaaact tcccagccta gacccgcgca 2311261 gcctaaagac ggattctccc agttgtcttc aacaaagcga atatcgtgct caagcggatc 2311321 aattccaaga gcacgcaagg aatccaaata cagctcttga atgttatcag gtgacggttt 2311381 aataatgacc tggaactgat gatgctgata cagtctgttc gggttctccc cgtagcggcc 2311441 gtctgccgga cgtctggaag gctctacata agccactttc cacggctcag gaccgatact 2311501 gcgcaaaaat gtatacgggc tcatcgtgcc ggctcctttt tctacatcgt aagcctgcat 2311561 aagcacacag ccctgactgg accaatgctt ttgcaaggtt agaatcatgt cttgaatatt 2311621 catttcaagc acctccactt ttctttcata agttgactgc ggcagcaacc aaaaaactcc 2311681 cgtctctatg cttgccagcc gcaaacatag ggacgagagt tctcccgcgg ttccacccta 2311741 gttgctgaga acaaaatccc agcctctttt ttaaaattgc tcaagaatgc ctttcgttgc 2311801 gtgctcatcc ttagcttaca ccgccctaag gtcgctttca tgaggtaaac gcaagtactt 2311861 ctttctctca ctgcaacata ttttataata aatgatcata taaaaagatg gaccaaatgt 2311921 caacttttgt tttcacccat aagatgtttc atgctttcca tttgatctaa aaagcgcttt 2311981 gattttaaat acaatcccga atattcttcg taatataaat caatcacttg ctttaattca 2312041 gcttttgttt cctcttttaa ggacacattg ccgagtctcg acagatcaaa atagtaaaag 2312101 agccttaaca gccttgccgt ttgcggttta atcggtatcc tgtaaggatc tttttcaaaa 2312161 cagcggtggc atataaaacc attatcacga acagagaaat gaaaggttcc gtcttggctt 2312221 ttacaatgta cacaatgatt cagctcagga tacaggccca tgacaccgag catcttcatt 2312281 tgaacaatga aggtgataac atccggatct gttccttcat tcaactgttt taatgattct 2312341 aatatgaatt caaataaata aggatttggc tttttttctt ctgtgcctct gtcgactaac 2312401 tcagcaacat aggcagcata tgctgttaaa aacaagtctt ccctgatgcc tctcatgctg 2312461 aggatcattt ccccctgctg aagcgttccg aggcccgatg ttttttgcat taagaaagaa 2312521 ccatacaaaa agggctggct gactgctgat aaacggctgt tcggtttttt ggcgcctcgt 2312581 gccataacac ctatttttcc gtgttctctt gtcagtaatg ttacgatttt attcgtctct 2312641 ccgtaatcat ttgtgcgaag aacgatccct tcacattttg tcagcatttc cgcaccttcc 2312701 tcaagcagga gcggccaaga ggtttataaa attggataat caaatcgggc tagctcatct 2312761 tctagttctt cgggtctttc catgttctct ttttccagtt ctttaaaaag aagatacgta 2312821 tcaacatttc ctgtttgaga aaatacgttc caggtaaaat tcaacacaag aaacccacct 2312881 ttctgtagtt aaactagctt acctaaactc caaattctta cctttatctt gaccagatgt 2312941 cctccatttc atgttaaaca aaatttgcta atgtatccct gttcctgtga gataatgaca 2313001 cacacgggaa gagattaata ttcgtcctct ttaaagccaa aatcgcgaag ctgggacatt 2313061 ttattacgcc agtctttctg cactttcacc cacaattcaa ggtagacacg ggagcccaac 2313121 agtgcttcaa tatccgctct cgctcttttt ccaacctctt ttagaaggct tcctttttta 2313181 ccgatcacga tgcctttctg ggaatcccgc tcgaccacaa tcgttgccgc tacgtgcaca 2313241 gaaccgttgt cctgcccttt gatggattcg atggccaccg caatgctgtg cgggatttct 2313301 tctctcgtca aatgcagcac cttttccctg attaattcag aaatgataaa tcgttcaggg 2313361 tggtcagtta cctggtcact cggatagaat tgcggccctt ccggcaaata cgcttcgatc 2313421 tgcgcgagca aggtttcgat gttatttcct tctaaagcag aaatcggaac aatttcctta 2313481 aaaggataac gtttgcggta ttcgtcaatt agcagaagca attggtcggg atgaatttta 2313541 tcaattttgt ttacgattaa gaatacaggc gtagacatcg tctgcaattt ctcaatgatg 2313601 aattcgtcgc ccttcccgta gccttcctca gcattgatca taaacaagat caaatcgact 2313661 tcttttaatg tattttgcgc cactttcatc ataaagtccc caagtttatg cttaggttta 2313721 tgaatccctg gtgtgtcaat aaaaatggtt tgtgatgtgc ctgtcgtcag tactccttgc 2313781 accttgtttc tcgtcgtttg gggcttatcg ctcatgatcg cgattttttg tccaatgact 2313841 ctgttcaaaa atgtagattt tcctacgttt ggtcttccaa taatggatac aaatcctgat 2313901 ttaaagcttt cgttcgtcat gtaaatcctc cgatgaaaat gcgcctggca ataattcttc 2313961 cacagtcatt tcttttattt gtccttgtaa attagtcagt acgacaataa cgtcttttgt 2314021 gcaaagctca gaaatcacct gtcggcaggc tccgcacgga gatactggtc caggggtgtc 2314081 agccgcaacg gccagcatct gaaactctgt atccccttca gaaacagctt taaataaagc 2314141 ggtacgctcg gcgcaattgc acatgctgta tgccgcgttc tcaatattgc agcctctgta 2314201 cacttttcca tccttggtaa gaagagcggc tcctacttgg aatttggaat acggcgcata 2314261 tgccatatca cgcgctttta aagcttctgt tattaattct tgtctgttca tgtgtacatt 2314321 cctctcttac ctataatggt accgctatca ctttatattt tacataatcg cgcgcttttt 2314381 ttcacgccca tttctaaaaa tgtaaaataa atgtaagaat tttcagccat tacagctttg 2314441 gcaaaaaaat aagtaaacca atgatacacg aaatcacggc aaaaacgcaa acagccccgg 2314501 cggcagcgtc cttggccgct ttagcaagag ggtgatgttt gtcagttatt aaatcaaccg 2314561 tatgttcaat ggctgtattt aaaagttcaa gcgaaaacat accacctatc aaaaggaata 2314621 taatcatcca ctcaataatg ctgagctcta caaggaagcc gcaaatgaga acagcgcagg 2314681 cggctgcggc atgaaattgg aaattccgct ccgtccgcgc tgtttcccat atgccccggc 2314741 ctgcatgcac gaagcttttg aagaatcgat tcagctcatt tctatgatct tttgagtcca 2314801 taagcgtcca gcaattcctt ttgcttagta aacatctcct cttcttcctc tttcgtcata 2314861 tggtcatatc ctaaaaggtg cagaaatccg tgtacagcta gaaatccgag ctctctttta 2314921 aaagaatgat tatactcctc tgcctgctct cttgtgcgat cggcactgat gataatatca 2314981 cctaaaaccg gaggcatttc ggcgcccacg atttcgatct cgccttctcc ctcttcttca 2315041 agagcaaatg agatgacatc tgtcggagca tcctttcccc ggtattcttt gttaatctga 2315101 tgtatgtcat cattggaaac aatcgtgaca gaaacttcag cctgatcctg aacgccttca 2315161 cgctcagcgg caaattgaag cagattttct acttctttga gcatctcttc tgagacgctt 2315221 cccgtttcat caacgatatc aatcagtaaa ctcatctatt tcaccttctt agtagcctcc 2315281 ggatattcaa tccgggagtg gaaaattcct tttaatgttg cacagagcgt ttttgcgatt 2315341 gtatccagct ctttaaatgt caaatcgcat tcactgaact gtccgtcctg aagcttatcg 2315401 gatataatac cccggacaag cttttcaatt cgttcaggat ttggattgtg catggatctg 2315461 acggccgctt caacactgtc ggccactgat ataattgcgg cttcctttga ctgcggcttc 2315521 ggtcccggat aacggaactc ttcctctgta atctggtcgc ctttttcctt cgctttatag 2315581 taaaaaaact ttaaaagcga ggttccatga tgctgctcag caatatcgac aagctctttc 2315641 ggaaatttat agcttctcag catattcgca ccgtctgtcg tatgcgagat aataatattt 2315701 ttgctcaact gaggtgacag cttgtcatgc ggattgtcaa tattcatttg gttttcaata 2315761 aaatattgcg ggcgctttgt ttttccgaga tcgtgataat atgcgccgac tcttgcaagc 2315821 aaaccattag ccccaaccgc ttcacaggct gcctctgata aattggcaac cattacactg 2315881 tgatgatatg tacctggtgt ttccgtcagt attttgcgca atagcggatg gttaggatta 2315941 gacagctcga gcagcctcat ggtggataaa atgccaaagc ccgtctcaaa aaacggcatc 2316001 agaccgatga tcaatacaga tgaagcaaac cccgacacaa cccccatgag cattaacgtg 2316061 ccgatttcaa gacccgacag cgcagtgttc tggatcaata ataaggatag aacgacaacc 2316121 atattaataa acgccacgaa aagtccggtc tgcaaaatct ttgatcttgc attgtgtttt 2316181 cctaaaaata atacacctga aatgccgctg atcaaataat aaatccctat gacataattg 2316241 aatgttcctg tcacaccctg attaaacatc atacttccgc aaatcgcaag aatgatactt 2316301 cccaaaatgg caatgcgttc attcatcagc agtttgatta agatggcgcc ggccgcaatg 2316361 gggaccagat agccgatatt attatactcc atcttctgaa acaaactgac aacctccatg 2316421 atcacaagca aaagtgttgt gattatggag aataacagaa tggattggtt tttaaacttc 2316481 agattttgtt tctgtttttc aaaataatat acaagtgttg caatgaaaag tccgatcata 2316541 atcaatagcc cgctgatcgg tttaaagaga tttgagttat ttaataaccc ggtcagctca 2316601 agtttcctgt acacttcccg atcaatgagg tcattttctt ccacgagcac ttgcccctgt 2316661 ttgatttgaa cctgctggac attatctgag gcttcctgcc gttttgcctc tgttgctttc 2316721 ggatcgaaga cgtaattcgg aataatagca aaacgcccga tttctgtcgc ggctcccaag 2316781 tatttagacg gaatagaatt gctctttagc tctttttcta ccttatcctt tgcatcagat 2316841 agtttatccg aagggatttc actgctcatg accgtattta ccgcggtaat gaccgtatct 2316901 ctgacaaaag aaaagtcttc actgtctgct ttcagcaatg tcttgatgga atcctccgat 2316961 atagaatcat tcacatctga tgtcaatttg tcctttacag atttgaccat tgatttttcc 2317021 gatggtgatt tactgccttc ttccgatgat tttttcactt cactaatact gtcgaatatt 2317081 gatgacacaa ggtcaatccg attgtctgta tattcttttt ttaatgtata ttgatcttca 2317141 accgcgtcct cagcggcttg ctttttttcc tctgtggctt tttgatcttc tacggttgcc 2317201 ggagcgtaaa tggtcttgtc gctgactgaa aacaggtcta aatcaagtgt ttccggctta 2317261 acatgtacaa agagcaaagc aaacataatg gcagccagca gaagatacag cagtacatgc 2317321 atggagcggg catttttaaa actgctccat ttttttgagc tgcttttggt cttagccttc 2317381 tttttcaaca caagaacctc ctcttgaaac atcaagccca taagcaatca taaaaatgac 2317441 ccgataacgc gcgatcgggt cattcagcat taattttgct tatcgtatgc ttcaataatt 2317501 ttcgcaacaa gcggatgtct gaccacgtct gtctggtcta gctcaatcat agaaatgccg 2317561 tctattcctt tcagcatctc cttcgctact gcaagtcccg atttgacgcc tttcggcaga 2317621 tcaatttggc taacgtcacc tgtaatgatc attttagagc caaaacccag tctcgtcaaa 2317681 aacattttca tttgagcagg cgtggtattc tgtgcttcat caagtataac ataagcatca 2317741 tcgagcgtcc gtcccctcat atatgcgagc ggagcaattt caatgatgcc tctttccatc 2317801 agacgttctg tatgatctgc cccaagcaca tcatggagag cgtcatacag cgggcgcaaa 2317861 taaggatcta ctttttcttt taggtcacct gggagaaaac caaggctttc accggcttcc 2317921 acggcaggtc ttgttaaaat gatttttttg atatgtccgt tttttaaagc atggactgct 2317981 tttacgacag ccaggtacgt tttcccggtt cccgccggac caatgccgaa tacaaggtca 2318041 ttccgcttca tagcggccac gtattcccgc tgtcccattg tttttacacg gattgatttg 2318101 ccttttgcgt tttttgtaat ttcttcttca tacatgcttt caaagtattc aagttcattc 2318161 ttctttgcca ttttgatggc gtaaatcaca tcacgttcag agatctctat ccccttgcga 2318221 attaaagcga ggagcgatcc cagcagcctg tctgcaatct gaaacgattc atcatcgcct 2318281 gaaacataaa tcgtctcgcc gcgcgtaatg atatttaaat tcagatcttt ctccatcaat 2318341 ttcaaaaaag aatcttggtt cccgaagagt gaaagcgcct cgtccgggtt tttcagtttt 2318401 tgattcatcg caagtaaatg ttctgtcatt cttcagtctc cctgacaata ggtgtggttt 2318461 gaacgatatc ttctataact tggtagagaa taatcaactt tactttacca ttctcaacag 2318521 tctggtgcaa aactttttca cttttcacct cgccgttttc gcctatttta tcctctacat 2318581 cctgtttacc caatttaatg ccttcttgaa ctgcttcttc ttttgtatat tttcgcaaag 2318641 cctcttcact ttctctcgtt tgctctttga cataggatac agggagctta aatccgagaa 2318701 aatgaagcga atgcttttct tgttctgttt ttggatgctt caattcctct tttttaaacg 2318761 tcatccccca gatcgggatt gccaaagaac caaaagaaag cttgtgcttt gtccttactt 2318821 tgcccgtata gacgttaaat aatgtttcaa gcgggactgt cacttctgat ctataccagg 2318881 tttctccata aatttctgct tttgaggcga cttcctgctg atggtcttcg ctgccgatca 2318941 gtcccgaaac aagcagctgt cccttttcaa catgatcgtg tatggcggcc atgggctgtc 2319001 ctttttgcac aaacattctc gtaatggttg ctttcttttt ggcgacaata ttgcgcgggc 2319061 taacatattt ttctttttcg ggctcatttt tctccacaac tttcatatga atggtcgtcc 2319121 ccttcagatc aactccgacc caagtgatat tgtctattcc attggttaat gatttctgta 2319181 ttttttcggg cgacatcatt aaaaactgca gacggccctt tttgacgccg atttcattaa 2319241 gatgctgcct catttgatgt tctgtttcag gcttagcgcc tgtcacatca attttccaca 2319301 ccatattgga cagcaaaaac aaaagaatga aaaaaatcgc aaaaccgatc gtaaacccta 2319361 tattcagctt tgatttcagc aacaggaagg gaaatccctt ccgattgata aatcgggctt 2319421 tacatttaaa tttacttctt acccgccgaa aggcatgtac atcctgaagc tgtatatata 2319481 acgatacggc ttctttcttt tttttgacat gaaagaccgg aatcccctgt cttgtgcatt 2319541 cattaaggag ccgctcaatc cctcttcccg tcaattcaag ctggacctta cccgaaaaaa 2319601 aagacagcca tttatttttc acaacatttc cccctcggct ttatgactca acatatcgaa 2319661 cgacatcaat cgtaccctcc aaaagtatct cttccggaag aatcgccttg atgacaaaat 2319721 ttttaccaga tatgatgcac tggccctgct tcagcatcag ccgcacttca ttctcactga 2319781 aaagcaaaag gcctctgtgg ttttctatgt agatatgaag tctgccaacc attgtaatcc 2319841 tcggcagatc catcataacg tccgggggaa tttccaatgc tcttgtcagc caagctttca 2319901 tacgattctt tctttgcccc atacaaaaag aacccccttt catctcatat gtatgatttg 2319961 aaaggaggtt ctaacacttt aatttttacg ggccgggcgc atcgtacggt gaggtttttt 2320021 cgcccgtgga ggtccgaaca cctctcctag aacgatcccc tgtacgacgg tgtctttatt 2320081 cacctgaagc attttttgtt ttgtgtatac tgttttttgt ttggcagcag caagatctcg 2320141 ttccagccct ttcaggtttc ttgctgtttc cctgcgtctt tcttccgctt cccgtcttgc 2320201 ctgttccata cggttaggga taggtgcagg ggcatcttct tttgactgct tcttttgagg 2320261 agaagcagat tgcacgtgtt gaggtttttt tcttttttgg ctgttttgct tttcttcttt 2320321 gctctttttg ccgaaaatcg cagaaatgat tccgatgatc gctgcaataa taagcggatt 2320381 ggtcagtaaa tcttccatca gcgttctccc ttcttagaga gattatgatt tgcggtcttc 2320441 atccgaaggg tctttcgtca gcttgccgaa tgaatcacgc atttctgtgt cagcatcgat 2320501 gttcttgata ttcatgtaat ccatgacgcc aatattccct tcacgcaaag cttctgccat 2320561 cgcaagcggc acttccgcct cggcttctac tactttcgcg cgcatttctt ctacgcgggc 2320621 acgcatttcc tgttcttgag cgacagccat cgcacgtcgt tcttccgctt ttgcctgcgc 2320681 gatgttttta tcagcctcgg cctgatcggt ttgtaaaatt gccccgatgt ttttgccgat 2320741 atctacatct gcaatatcaa ttgagagaat ttcaaacgca gttcctgagt ccaatccttt 2320801 tccaaggact gtctgagaaa tcatgtcagg gttttcaagc acttttttat gattatcaga 2320861 tgaaccgatt gtagaaacga ttccctcacc tacacgagct acaatggttt cttcccctgc 2320921 tcccccgacg aggcgctcga tattcgctct tactgtgatt ctcgctttcg ctttcacttc 2320981 aatcccgtcc attgcgacgc cggcaatgaa cggtgtttca atcaccttag gattaacgct 2321041 catttgaaca gcttccaaca cgtcccggcc tgcaagatca atggcagcac agcgctcgaa 2321101 tgtgagttca atgttagctc gctgagcggc gataagcgcg ttgacgactc tgtcaacatt 2321161 acctccagcc agatagtggc tttcaagctg gtttgttcca acattaagtc ccgctttatg 2321221 cgctttaatc agcgggttaa caacccgatt cggaatgacg cggcgaagcc tcatcccaac 2321281 tagagtgaaa atgctgattt tcactccggc tgccaaagct gaaatccaaa gcattacagg 2321341 cacaaatgta aaaaatactg ccaaaacaat gatcgctact gcgacaattg ccagaatcat 2321401 aagtgttgac ggatccatat aacttctcct cgtttctatt taaatttctc tcacgacaat 2321461 gcgtgagcct tctactttta tcacttttac ttttttatct ttttctgtaa acgatccctc 2321521 cgatacaacg tcaaggcgtt catcatcaat aatcacggta ccggaaggac gcagcggtgt 2321581 aaaggttata cccacttttc ccattaagtc cgtgcgcgtt tgatttgaaa cgtagccgct 2321641 ctccgtgttt gtagaatcat ttaatatcaa tttcttaaag aatttcatac gctttcccaa 2321701 cacccttgtc agtaaaataa aagctgtaat cgaaacagct gaggcgatca agagagaaac 2321761 cgccatgaca gtgaagctcc ccgcggctaa aaacaggctc gcaataatcg ctcccaagcc 2321821 cagtaatcca atgattcctc cgggaagaaa aatctcaagc agaatgagaa tcacccctgc 2321881 tataaagagg agaaccgtct catacccggc aaggccggct gcaagatgcc cgtaaaagaa 2321941 cagcaataac gcaatgagtc cagccgttcc agggaggccg acacccgggg aaaaaagctc 2322001 taccgtcaga cctaaaaaag cgattgtcag cagaataggg acaatgaccg gattcgtcag 2322061 ccatcttgcc gtcttttccg caaagctctc ctttgcatag ctgatctgcg ccttttcgaa 2322121 cccaagcttc tttacgagcg tggacaaatt gtcagcagtg ccttctgaat agcctacctc 2322181 aatcgccttg tctgcgttaa gtgtcagcag atctccctta ggcgcgccaa cttccttggc 2322241 atctatatct gggtcagcca ttgcgagcgc atattttgga tcgcggttat ttttcactgc 2322301 ggcatcttcc atctctgcca gccaaagtga ttgagctttt tggtcagcgg cattgccttg 2322361 gccatcaaca atcgcggcgg ctcccatttt tccgccaggc gccatataaa tgtgatctgc 2322421 ttgaagtgca atatatgcac cagcagacaa cgcgcgtttg ttgacatatg cagttacggg 2322481 gatctcgctt tcggttatca aatcggccat atcaatagca gatttgacca atccccccgg 2322541 ggtattgata tcaagaataa tatggtctgc atgtgcatcc tttgcgtctt gtaacgaacg 2322601 ggacaaaaac gaggcgagac cctgttcgac atttttttca accgggatca cataaacagt 2322661 ttgtttttct gcttttgcgt tcagctgtac gcctaataaa gaaagtaaaa atatacccaa 2322721 aagagcagca cggaatcctt tgatttgaag caagggcggt gtatccctcc ttccttttat 2322781 aataagtgcc ttctcttcat acgtaacaaa tgtatcaaag gtttcatttt tttatgtata 2322841 aaaaaagaca tctctcttag aaagatgtcc ttttctttgc catttaagac agttgactgc 2322901 tcacaagctt attaattaaa cttccgtcag ctttaccttt tactttaggc ataattgccc 2322961 ccatcacttt gcccatgtcc gcttttgagc tcgcaccgac ctccgcgatg gtttcattta 2323021 cgattgtacg cagctcttct tctgacagct gctcaggtaa ataaacttct aaaatgtcca 2323081 gctctttttg aactttatct actaaatcta aacgattagc gtttgaaaat tcctggaggg 2323141 agtctttacg ttgcttaagt tcacgagaaa ggacagtgag ttcctcatcc tcggtcaaac 2323201 tgtctttctt aagcttaatt gcttcatttt gaagtgaagc cttaaccatt cgaacgacag 2323261 tcagtttgtc tttctcacgg tttttcatat acagcttcat atcctggttg agacgctcaa 2323321 gaagactcat aaatccaccc tcttttagaa tttgcgtttt ctagcagctt cagacttttt 2323381 cttgcgcttt acgctaggtt tttcataaaa ttcacgcttt cttgcttctt gcaaagtacc 2323441 tgtctttgat acactgcgtt tgaagcgacg aagagcatct tcaagcgatt cgttttttct 2323501 aacgaccgtt tttgacattc tctttccctc cctccgaata caccaatcga ctacctttaa 2323561 gttacacata taaacatgta ctttgacatt ataatataag ccatcagtca ggtcaactaa 2323621 gtgagttcac ttttccgtca tgagtgcgac tgcctgtcta tataatgaaa gaaaggggtt 2323681 ggtgaatagg atgttaattc tgattagctt tactgctctt atattattct ttctcgcagg 2323741 catgaacatg cttcgaaagg gcttaatttc aatggcgtac tcaaaaattg aagaacgttt 2323801 gcttttattt acagaccatc cgttaaaagc gtttcttatc agtattgtat ttacggggat 2323861 acttcagagc agctcagcct ttatggtcat tgtcatcggc tttgtaagtg cgggcgttct 2323921 ttcttttaag cggacgatcc cgatgattct ggggacaaat gttggctcta cttttacaac 2323981 tgaatttatt gctatcaaaa tggatattgt gatttgggtt cttttaatag gaggtttatt 2324041 gttttttctg actggcaggt atcctttgaa acagctggga acaagcttcc ttggactggg 2324101 catcatcttc ttttgcatca gcggattcag ccatcttgcc gggccgctga caaagctgaa 2324161 aacgggcgcc gacgttctat accatgttaa cgattcaaac tggtccgctt tgctcatcgg 2324221 catggtgtta actgccatca ttcactccag ttctgtctgt atcggcattt tgatgagttt 2324281 tatgaatgaa gggattatcg gactgacaca ggcgatgagc gtcgtactcg gatcaaatat 2324341 cgggacatgc attacagctg tcatggctgc tgtatccggc ggatatgcgg cgaaacagac 2324401 agcatatgcc catgtggtat ttaacgtgct aggggtggct ctagtattgc cttttctgac 2324461 cgcagcgacc ggctttgtag agcagttatc acctgatccc gcacaaaaga tcgcgcattt 2324521 cagcctttta tttaatgtgg tgacagctct tttatttctt ccgcttacaa acttgtttta 2324581 ccgattgatt caccttctta tcccggctaa ataaaaaaat cggtacattt taatgcaccg 2324641 attttttagg ttaagaagac aaacgcatgt gttcagttat ttcatcctca accacacgga 2324701 caaactgtcc ttcgttgtaa ggataacctg cttttaggat tttgactttt acgattttgc 2324761 cgatcatatc ttccgtacct ttgaaaacaa ccttcatata attgtctgtg taaccgacaa 2324821 acatattttc ttcttctgtt tccttaaacg cttcctcagg gataatctca agcacttcat 2324881 tttcatactg agaagcgtat tcttttgcaa gctggtcaga aagagcaatc aggcggtgca 2324941 cacgttcgtt tttcacgttt tcatccactt ggtcttccat tcgtgcagct ggtgttcctg 2325001 tacgcttact gtaagggaaa acatgcagct cagagaattt atgttcttta ataaagttat 2325061 aggtttccat aaattcttct tctgtttctc cagggaaccc gacgatgaca tcagaagtaa 2325121 cagctaagcc tggcagtgct tttttcaatt tatttaaacg gtctgcaaag aattccattg 2325181 tatatttgcg tctcatccgt ttaagcactg tgtttgatcc ggattggata ggaatatgca 2325241 aatgattcac tatcttatct gagcggtcta agacctcgat cacttcgtca gtgatttggc 2325301 tggcttcgat tgaagaaatt ctgatccgtt tcacgccttc cacacgggtg tctaattcgc 2325361 tcaaaagctt cgcgaagttg taatctttca tatcttcgcc gtagccgcct gtatgaatac 2325421 ccgtaagaac aatttcctta tatccggcat cgacaagctg ctgcgcttgt ttaatgactt 2325481 cttcagggtc gcgggagcgg agcaggcctc tcgcccacgg aatgatacag aatgtgcaga 2325541 aattattgca gccctcctgt attttcaatg acgctcttgt gcggtccgtg aaagcaggca 2325601 catcaagctc ttcatatact cttgctttca tgatgttgct gacgccatta atcggctggc 2325661 gttcttctcg gtattggtca atgtagccaa gcattttttc acggtcctgt gttccgacta 2325721 caatgtcgac accggggatc gccataatct cagcaggtga ggtttgcgcg tagcagcctg 2325781 tgacacagat gacaccgtca ggattttgac gaatggcgcg tctgatcact tggcggcttt 2325841 ttttatctcc cgtatttgta accgtacatg tattaatgac atatacatca gctgtttgtt 2325901 caaagtctct tctttcatag cccgcttctt tgaaaagctg ccagattgct tctgtttcat 2325961 aatggttgac tttacagcca agcgtatgga aagcaacagt tgccattact gatcacctct 2326021 taataactct gtttgataag aaatcgcact caacgcgtat agcggagcgg tttctgtcct 2326081 taaaattctc ggtccaaggc cgcacgtcac accgtcttgc tctgtgagcc gttcaacctc 2326141 cgcttctgtt aaaccgcctt cgggaccaaa tacgatcaat agagatgatc ctttcggaag 2326201 gctgcttaca atcgcgctga atgcgcttat ttccccttgc ttcgatgact cctcgtatgc 2326261 aacgacacat ttatcgaaat cctgcatcct ttgaagaagc tgctgaaaag aatggacatc 2326321 catcactcgc ggcacttcgt tacggtacga ttgctcagcc gcttccttcg caattttcgt 2326381 ccatctttcc cgctttttct ttgccttttt gtcatccagc ttgacaacag aacgcgcggc 2326441 ttggaaagga ataaaggcat gagctccgag ctcagtcccc ttttggataa tccattcaag 2326501 cttatctcct ttcggaaggc cgctcgcaat atagaccttt atcggaagct ctctgttttc 2326561 attcgtccat tctatcacaa ggcaggacac tttatctttg gaaacagatt gaagttcaca 2326621 ttttgcctcg aagccgtctt gagagcagca gataatctga tctccctcat tcattctcat 2326681 cacgttcaca atatgatgaa cttcttcgcc ggtaatcgaa aaagtcggcg cttcctctat 2326741 ttgctgcttc gtgagctcga taaaatatcg ttgcatacgc tgtgacacct actaactgtt 2326801 attttttcgc aataatgctg acccaatctt ccattgaaag gatttctaca atggtaaagc 2326861 cagcttgttc cagtgcttct tttacttctt gttttttatg accgatgatt cctgacgtaa 2326921 taaagtgacc gccttctttt aacaggctgt acgcttgtga agtaaagcga agaatgactt 2326981 cagccaaaat gttggccaca atcacatcat gttccccttc aatcccgtct aacaaattgt 2327041 tttgcttcac ttgagcaata tcgctgactt tgttcagctt gagattgagg cgtgcacttt 2327101 ctacagccac gggatcaaga tcgtaggcat gaaccgattc agcctcaagc attgcagccg 2327161 caatacttaa aattcccgaa ccagtgccga catcaatcac cttatcaccc ttttgcacaa 2327221 agcgttcaag cgcctgaatg cagagtacgg ttgtcggatg tgtccctgtg ccgaaagcca 2327281 ttcccgggtc catttcaata atcagttcat cagtatggac cggcgtatat tcctcccacg 2327341 tcggcacaat tgtaaacttt tcagaaattt tcacaggatg ataatacttt ttccaggcag 2327401 tcgcccactc ttcttcattt acttcagaaa tagtgatgtg gtttctgccc aaatcaatat 2327461 tgtaaagaag gagattatta atcgtttctt tgatgccgtc tacagtttcg cccagaaaac 2327521 tgttaaccgg cagatatgct ttgacaatga caccctcatc tgggtaatca ttggggtcga 2327581 gctggtagat ttccccgtac acattctcac gttctttaat taaatcaagc gggtcctcta 2327641 tcacaacccc acttgcacca gcttcatgca atatatttga gataggttcg accgcttcat 2327701 gtgttgtgtg aatgcttaat tcggaccatt tcaaaactac caactcctca tccaataatt 2327761 aatcgccttt aaacgcgcgt tttaccttgt caaagaaact catttcctgt tcgtcaggca 2327821 ggtttccgct gacttcggca aattcgcgga taatgtcttt ttgtttatca gtcagatttg 2327881 tcggcgtaac gacgcggacg acgatatgct ggtcaccctg tccatagcct ctgacatttt 2327941 gaacgccttt gcctcttaat ctgaatttcg ttcctgtttg tgtaccggcc ggaattttca 2328001 atttcacttt tccatgcagc gtcggcactt ctacctcatc tccaagagca gcctgagcaa 2328061 acgttaacgg catttcacag taaatatcat cgccgtcacg ctcgaagaac tcgtgtgcgc 2328121 gtacatggaa cacgacaaat aaatccccgg cagggccgcc gtttattcct ggttcaccct 2328181 gtcccgagag acgaagctgc tgcccgtcat ctacaccggc tggaattgtc acattgattt 2328241 tcttgcgttt tttgattttt cctttgccgc cgcagtccgc acatttgttt ttaatgattt 2328301 tgcctgtacc ttcacagtgg tggcagaccc gtctgttaac gacttttcca aacggtgtat 2328361 tttgctccac gtttaactgg ccggagcctc cgcagtggga gcatgtttct ggatttgttc 2328421 caggtttcgc acctgagcct ttacatgttt cgcacgtttc ctcgcgggga atttcgatgg 2328481 ttgtttcttt accgaaagcc gcatcctcaa acgacagggt catcgtatac tgtaaatcag 2328541 caccctggcg cggagcgttt ggatctcttc gtcttgtgcc tccgccgaat atacttgaga 2328601 aaatatcatc gaaaccaaaa ccgccgaaat cgccgccgcc aaaacctccg ccgccgaagc 2328661 cttggttagg gtcagtgtga ccaaattgat cgtaatgcgc acgtttttgg tcatctgaca 2328721 gcgtttcgta tgcttctttt acctctttaa atttttcatc tgatccggct tctttgttaa 2328781 tatcaggatg atattttttt gacagcttcc gataagcttt tttaatttca tcctttgaag 2328841 cgctcttact tactcccagc acttcatagt aatcacgctt actcatctcg cttcactctc 2328901 ccgaatttct cacataaatt agattgtatc attttgaatt atgatttttc aattcctttt 2328961 atcccgggca agaaaaaaag tcaaagccaa gagatgcctg actttgactt tctaatcatt 2329021 gaatcagatt atgaaatgtg ttcttttcgg tcagctccgg aagcggggct gacactaaaa 2329081 agaacttatt ttttgttttg gtcgtcgttt acttcttcgt attcagcgtc gacaacgttg 2329141 tcatccgctt tgccttcagc gtttgctccg ccttgagctt gctgtgcttt agcagcttct 2329201 tcataaagct tcatagaaag ctcttgaacg attgtttgaa gctcatcttt tttcgctttg 2329261 atctcttcaa attcgttttt ctcaatcgct gcttttaaag cgtctttggc atcgttggct 2329321 tttttcactt gttcttcgtc cactttgcct tcaagatctt ttaatgtttt ctcagtttgg 2329381 aaaacaagct gatctgcttc gttgcggact tcgatttctt cttttttctt cgcatcagcg 2329441 tcagcatttt cttccgcttc ttttaccatg cgttcgatct cttcatctga gagacctgaa 2329501 gaagatttga ttgtaatgtt ttgttctttt cctgtgccta agtcttttgc tcttacgttt 2329561 acgataccgt ttttgtcaat atcgaaagaa acttcgattt gaggcacgcc gcgcggtgct 2329621 ggcgggatat cagtaagctg gaagcggccg agtgttttgt tgtcggcaga cattgggcgc 2329681 tcaccttgaa gaacatggat atcaacagct gtttggttat cagcagcagt tgagaacact 2329741 tgagatttgc ttgttgggat cgtcgtgttg cggtcgatca gttttgtaaa cacaccgccc 2329801 attgtttcga taccgagaga aagcggtgta acgtcaagaa gaacaacatc ttttacgtca 2329861 cctgtgataa cgccgccctg aatcgcagca ccaagcgcta caacttcatc cgggtttacg 2329921 cctttatgcg cttcttttcc agtttctttt ttgattgctt cttgtacggc agggatacga 2329981 gttgatccgc cgacaaggat gactttgtcg atttcgcttg cagaaagtcc tgcatcttga 2330041 agcgcttgac ggacaggacc cattgtgcgc tctactaaat gagaagaaag ctcttcgaat 2330101 ttagcgcgag ttaatgtaag ttcaaggtga agcggtcctg cttctccagc tgtgataaac 2330161 ggtaaagaaa tttgcgtaga agatacgccg gaaagatctt ttttcgcttt ttcagctgcg 2330221 tctttcaaac gctgaagcgc cattttgtct tttgacaaat caatgccgtt ttcttttttg 2330281 aattcagaca ccagatgatc gatgataact tggtcaaaat cgtccccacc cagacggttg 2330341 tcgccggcag ttgaacgaac ttcgaataca ccgtcgccaa gctcaaggat ggaaacgtcg 2330401 aatgtaccgc cgccaaggtc gtatactagg atcgtttgat cttcatctgt tttatcaagt 2330461 ccgtatgcaa gcgctgctgc agtcggctcg ttgatgatac gttctacttc aagacctgca 2330521 attttaccag cgtcttttgt tgcttgacgc tcagcatcgt taaagtatgc aggaactgtg 2330581 ataactgctt ttgatactgt ttcgccaaga tagctttcag cgtatgattt aaggtgttga 2330641 aggatgatag cagacacttc ttgtggagtg taatcctttc cttcaatttc aactttataa 2330701 tcagtaccca tatgacgttt gatagacata attgtgttag ggtttgtaat agattggcgt 2330761 ttagccactt cccctacttg acgttcgccg tttttaaatg caacaactga tggcgttgtg 2330821 cggtttcctt cagcgttagc aataacttta ggctcgccgc cttcaagcac tgccacacat 2330881 gagtttgttg ttcctaagtc gattccgata actttactca cttgaataac ctcctgctat 2330941 gtaattattg attcactttg accatggaag ggcgaatgac gcgatccttc agcttatagc 2331001 ctttttgcat ttcctcaaca acaatgttgg agccgtagtt ttcgtcttca gcctgcataa 2331061 cagcttggtg cagattagga tcaaattcct gccctacagc ttcgatggct tcgacgcctt 2331121 cttttttcaa ggcttctacg agctgacggt ggaccatttc cattccctgg agcaaacttt 2331181 tcgtctgttc attgtcggct tcaacctgaa gcgctcgttc aaaactgtca agagccggca 2331241 gcaaatcagt cacgatattt tgagaacggt atttttggga cgcttccatc tctaaacggc 2331301 tgcgtcgttt atagttttca aagtctgctt gaacacgcaa aagtttgttt tctttttcct 2331361 caagcaaacc ttgcaattcg ttaatttggt tttgaagaag ttcgctttca tttgtttctt 2331421 cctgctgttc atcagcggca gcttgttctt caatgatttc ttgctcttct gtttcgtttt 2331481 gttcaacggt ttgtttttct tctgacattg tgttcacctc cctcaaagtg taaggagaag 2331541 gacaggtgct gcccttcgat aaaatttgcc aaaattccct tattcatcat acagacttgt 2331601 taatgctttt gacaagtccg aagtcacatg ctgaagcagg ctgacaaccc tggaataatt 2331661 catgcgggtc gggccgataa tcgcaattga gccgatctgc ttctggtcta cggaataaga 2331721 agccgtaatc agactgcaat tttccatctc ttcatagtcg ttttcttttc cgattttaat 2331781 cgaaattccc gtgtgcgggg attgaaccag ctttaaaaca tcctgttctt tctcaattaa 2331841 tgaaagcagc gaccgaactc gggtgatatc atggaactca ggctggttca gcatattgat 2331901 tttcccgcca aaaaacaact tttcaacgtg atttgtggaa tgaaaggttg aacgaagcgc 2331961 gtcgagtata ttgtcatagt ttttaatgtg ctgtcttagg tacatgacaa cttctttaaa 2332021 tatgcgctca ttcagttcat ccattggaac gccgcttaaa cggtcgttca gtatatttac 2332081 cagtttttca atatcagaca gatccatttt ggtcggaaag ttaatcgttt tgttttccac 2332141 atgccccgta ttggtaacga gaatcgctac cgccatatca ggctgaatcg gaatgatttg 2332201 aatctgttta aggtaattct cactcaactt cggcccgagt acgatggatg tgtaattcgt 2332261 cagatcggac aaaatttgcg ctgatttttg aactgtcttc tccagctcga aaattttctc 2332321 tttgaagatc gagtggattt ggtccaggtc gcttttcgtc aatttgacgg gtgacagcaa 2332381 atggtcaaca tagtaccgat accctttttc tgacggaaca cgtcctgagg atgaatgggt 2332441 tttttcaata aagcccaatt cctccaagtc agccatctcg tttcttattg ttgcagagct 2332501 aaatgtgatt tcatcttttt tcgaaagagt tcttgatccc accggctgtg ccgatttaat 2332561 aaaatcgttg attataacct gaaggatcag cagctgacga tttgttaaca tcatcatcac 2332621 ctctgttagc actctcaata agcgagtgct aattctataa caaaagtatc aaaccacaag 2332681 aaaaatgtca attataactc acccaaaaaa gcgccaaaaa cttcattgcc taataatttc 2332741 ccttgatgag tcaaataaac ggcagactcc gaattgtgaa tcagcccttt ttcagcgagg 2332801 tcttttaaca cgcttgggaa aagtccatcc agggaacggc cgtatttttc tgcgaatcgt 2332861 tttttgctga caccggctgt ttttctcaaa cctaaaaaca tttcttcctc aatctgttct 2332921 tctgttgtca cttcatgtgt atctctgtac ggaaaaccct tttcagctat caggtcaatg 2332981 taatgcttaa caggtccgac gttcactgtt cgtgtgccgc caatatatcc gtgagcgcca 2333041 gctccgaaac cgaaatattg ttcgttgctc caatacgtta gattgtgctt agattccatg 2333101 cctgccttag caaagttgct gatttcatat tgatgaatgc cgtgagcttc catcttgctc 2333161 atcactattt catacatttc agcttcctgc tcctgcggcg gaagatgaag ccgccctttt 2333221 tgcatcaaat tataaaatac cgttttcggt tctacaataa gggagtaaac ggaataatgc 2333281 tcagcgtcca atgataaagc agtgtttatg gaatgttcca gatgcttgag ggtttgcccc 2333341 ggaagcccga acatgagatc aagactgata ttctcaaaac cgatttcccg cgctctttca 2333401 aaagaggtga atacatcttt ttgcttgtgc actcggccga ttttttctaa cagatcgtct 2333461 tcgaacgttt gcacaccaaa gctaaggcga tttacgcctg cttcttttaa tatttttaat 2333521 ttctctgcgg acaaatcgtc cggattcgct tcaaccgcaa attccgataa gtcgcttgag 2333581 ggctttagca cgcggttgat catatccatc agctttttaa gctgttcctc agacagggag 2333641 gtcggcgtgc ctcctccgat aaagattgtt ttgagatcag gctgcccggt ttttgctatt 2333701 gtatttatca tttcctgttc gagtgcgttt aaatactcgt cgactggctg actttgaata 2333761 aaatatttat tgaaatcgca gtagtggcaa atatgctcac aaaatgggat atggatataa 2333821 gctgatttca acggattcac cttctttaca gaaagaagcc gcagtacaag actgcggcgg 2333881 cttctattgt tttttcggac tgtcgtccat tttcagaact gccataaatg cttcttgcgg 2333941 cacttcaact gagccgacct gcttcatacg gcgctttcct tctttttgtt tttcaagaag 2334001 tttccgttta cgcgagatgt cccctccgta acatttagcc aatacgtttt tacgcattgc 2334061 ttttatggtg gagcgggcca cgattttctg gccgattgcg gcttgtaccg gaacttcaaa 2334121 ctgctggcgc ggaatgagtt ctttcagttt ttcaacgatc acttttcccc gttcatatgc 2334181 gtaatcacga tgcacgataa aggaaagggc atcgattttt tcaccattca gcataatgtc 2334241 cattttcaca agcttggacg gtttgtagcc gatcagttca taatcaaagg acgcatagcc 2334301 tttagtgctt gatttcagct gatcaaaaaa ctcatatacg atttccgcta atggcatatc 2334361 ataaatgatg ctgacacggt ttgcgtctaa atactgcata tcaatgaaat tgccgcgttt 2334421 tccttggcaa agctccatta cagcgccgac atagtcattc ggcaccatca tcgtcgcttt 2334481 tacgtatggc tcctcaaccc tttcgatctt ttgaggatcc ggcatgttgg acgggttgtc 2334541 gacaacgacc ttttcgccgt ctgtcatata cacgtcatag ataacgcttg gcgctgtcgt 2334601 aatcaggtcg atgttgaact cacgctcaat tcgctcctga atgatctcca tgtgaagcat 2334661 gcctaaaaat ccgcagcgga acccgaatcc aagcgcttgc gaagtttccg cttcatattg 2334721 aagggaggaa tcattcagct caagcttttc aagagcttcc cttaaatcat tatacttcgc 2334781 tgtatcaatc ggatacaaac cacagtacac catcgggttt agcttgcggt atcccggcag 2334841 cgcttcttct gcaggattgg cagcgctcgt tattgtatca ccgacacgtg tgtcaccaac 2334901 atttttgatt gaggcagtca ggaagcctac atcaccgacc gtcagttcat ttgtcggagt 2334961 tgctttcggc gtgaacacgc ccacctctgt tacttcgaat tctttgccgg ttgccatcat 2335021 tttgattttt tgtcccggct ttaccgttcc ttcaacgact ctgatataag ccacgacacc 2335081 gcggtaggcg tcataaagcg agtcgaagat cagcgctttg agcggcgcct ccggatctcc 2335141 ggtcggagct ggcacctttt ctacgatttg ttctaaaatc tcctcaatcc cgataccggc 2335201 ttttgctgaa gcaagcacgg cttctgatgc gtcaaggccg ataacgtctt ctacctcttg 2335261 gcgcacacgt tcgggctcgg cgctcggaag gtcgatttta ttgatgaccg gaaggatttc 2335321 aagatcgttg tcaagcgcta agtagacatt ggcgagcgtc tgcgcttcaa tcccctgggc 2335381 tgcatccacg acaagaatcg ctccctcgca ggcagcaagg cttcgggata cttcatacgt 2335441 gaagtcgacg tgtcccggcg tatcgattag atgaaagata tattcttctc cgtcttttgc 2335501 tttatattta agctgaacag agtttaattt aatggttatg ccccgctcac gttcaagatc 2335561 catagaatcg agcaattgtt ctttcatttc tcgttgagtg attgccgacg ttttttctaa 2335621 aatacgatcc gctaaggtcg attttccgtg gtcaatatgg gcaatgatag agaaattccg 2335681 tattctcgat tgcctctcta aacgcttttc tttatctgtc acaatctatc actcctacta 2335741 ttaaacgcaa aatacactag cttagattat atcaatagga ttgtaaagat tcaatgtaaa 2335801 acaagaaaga gaaaagttcc ctatcatatc tgggttgctt ttctctttca cgtacttatt 2335861 gattcatatc ccgtatccat tcatacattg actgggcagt attggttacg gtgtccgaaa 2335921 gcgcttttcc ggcttttgaa aacatattga atgtctccac cttttccagc tctttttgtt 2335981 tttctactaa atcttttgcc gtgactgttt ctcctaggat tgaggcttct ttttcattat 2336041 cttttccgtc ggtgagcgta aacgccccct tcagtgaagg gtcatgatag cctttcatac 2336101 tcagcatccc gtggtttgcc tgctgcatgc cgaacagaac gcctaaaaac atgatcgtga 2336161 caagcagtaa gcactttcca aagtatgcaa tcaaatcaac cacctatttc ttattgtttt 2336221 ttcgtctccc cgctcgctgc gttgaccttt tcagcatccc agtacatttc gctgaatacg 2336281 tccgcggccg cgttagccgc acgctgcagc tcttcgagat tattatccac tccgccaaac 2336341 tcgagcaaaa gcgctctatc ggttaaatcc tgattgtaaa caccattatc gcctggcgag 2336401 cctttggaaa agacacctgt gctaagtccg gggtattttt tctccatcag tttatgaagc 2336461 tcactcgcaa ttttatagtt ttcttcgaag tttttgcttt ttttcccgac gacaaaggct 2336521 accctggcat agcttttccc tttaatcgtt gcggttgtgt cttttttgcg ccgagagtct 2336581 ctgtggatgt caatgatata ttgcagattt ttgtttgaag cgagggcgtc tttcacgacc 2336641 ggccttgatt catcatagga cctggcatag tttaagcctt ttttattcaa ttttgactgt 2336701 atatcggttt tattcactgt ggctccgatt ccctgggatt caagcgcttg tccgaacata 2336761 tctcctacaa gcgtgacatt ggctttagaa tggcgcgcca tgtcaggatc ggtctcgcct 2336821 tttaatagag ggagatatga ttccgtattg tgcgtgtgat agataaacac gaccttttta 2336881 tcacctgttg tttgtttcgg cggatctttt tgcgcattat ctgattgcgt ttgctgtttt 2336941 tcaatctctg ccaaattcgc ttctctttct tcctccatca ccttagacgg cggcggcgat 2337001 tccgcaggca tattcgtata atccgttcct tgtccagcta acaaaatctc ggtatcaaat 2337061 tgtgcaaatc ctggcagctc ccgaccgaga aagctccgcg gatcttcgag gttaatgctc 2337121 gtcgccagct ttaaagaaag acgagaaaga tgaaatgagc tgtctgtttg agagaggtca 2337181 gaagcgaaat aatggttttc catctgcagc aaatgtgcaa atacgtcacc cggcaattct 2337241 tcagcaatcc cataaaaaga gtcagacgac ggcctaagtt ccggccggag agacgtcagc 2337301 acaccggata gaacaaaaat cacgataagg cttacgataa atagaaagat ggcttttacc 2337361 gctttccctc catttaccgc aacaacaatc tgtctgtttc tgcgtttatt tctcattgaa 2337421 tccctccagc gcttgtctag taattactct atgaacaagc tagaggaagt agaactgttt 2337481 agtgattgta ggagcctttg ttttcttgtg acactttttc atgaagcgct gtgtttaatc 2337541 cgttcgctaa aacatttgcc atatcgtcga taaatgaatc gacttccttc ggtgtaacca 2337601 ttaagttgtg ccctaaaggc gaaagcacct cgtgaatgag ctgccgtttt tcatcttctt 2337661 gaagggttcc gacaatacct aggaacgatt ggcgctgctt ttgatcggga agatcgtctt 2337721 cagtgagcac tttctttttc ccaaacgtca tgcctgccgg aacaagcgat cttgatggcc 2337781 tgttatcctt catttctctg ccaaaatgtt ttaatatgta gtccaccgtg tcgctggcaa 2337841 ttgtcacggc atcaactact gtcggaacac cgatagcaat caccggaaca ccaagcgtgt 2337901 ctttgcttaa atcttttcgt ttattcccca ctccagaccc cgggtgaatg cctgtatccg 2337961 atatttgaat ggttgtgttg accctttcca ccgcccgcgc cgccaacgca tcaatggcga 2338021 tgacaaaatc aggcttcgat tgctcaatca cacctttaat aatgtcactt gtttcgattc 2338081 ctgttatccc cattacaccc ggtgcaaaag cactgacagg cctgtaaccc tcctgtacgt 2338141 tttccggctg aagcttaaac aagtgccttg ttaccaacag attttctact gccatcggtc 2338201 caagcgcatc aggtgtcacg ttccagttgc cgagcccaac gatcaaacag ctcgcatctt 2338261 ttgagatatt aaggttttca agaaaagctg agaattcctc cgcaaagaca gcagagacct 2338321 tctcctgcat ttccgaatca ttctccctga ttccctgtgc ttcaagcgtt aaatagcgcc 2338381 cttctttttt tcccgaaagc tctgcgcctt cctttgtaac atcaactgtg cggattttaa 2338441 tgccgccgtg atcacgctct ttttcaataa agcctttaat ttcttttgtc ggcacagcct 2338501 gctgattggc cattgcttcc ttcgtttcca ctgccaaatc ggtccgtatc aaatactgat 2338561 tcacatccag ctcactcttt ttcatacagg ggcctccttc acattaagta cctatattgt 2338621 tgccatttgc tgaataaatc atgctaaaaa gagaaccttc aatgaaaaat actttacatt 2338681 tatattgcaa tctaaaggtg tgtttgatag aatacaattt gttctattgt gaagaagatt 2338741 taaccttaag acactgtgct acaggttgta tcttaggagg tgaaacacat gccaaacatt 2338801 aaatcagcga ttaaacgtac aaaaacaaac aacgaacgcc gcgttcataa cgcgacaatc 2338861 aaatctgcta tgcgtactgc aatcaaacaa gttgaagctt ctgttgccaa caacgaagct 2338921 gacaaagcga aaactgctct tactgaagca gctaaacgta ttgataaagc agtgaaaaca 2338981 ggtcttgtac acaaaaatac cgcagctcga tacaaatcaa gactagcgaa aaaagtgaac 2339041 ggactttctg cataatataa aaacgatcct caataatggg gatcgttttt ttcatttctt 2339101 tttaacagct gtaaaaggaa cagttcgagc aggagctgct tgtccttttt cccggttttc 2339161 atctcatagt ccatgacggc aagctgttca ataattaaac ggagctcctc ctctgaaaaa 2339221 agccttgctt gatccatcgc cagctttacc cgaaatgggt gaacttttag attagaagcg 2339281 atttgttttt gtccgtatcc ctgttccgcg aagtacttcg tctgcagaat cagccggaac 2339341 tgattcgaaa taagcgccat aattttgatc ggttcttcat tttgttttag caaatcataa 2339401 aaaatttgca gactctctgt tcgttttcgg ttgacgattt tattgatcag ctcaaaaata 2339461 ttttgttcaa ggcttctagc aacaagcatt tttacatcat ccagcgtaat ttcttcacga 2339521 tctccaataa acgtgcagag cttttgaatc tcctgaaaaa tcgatgacag atgaccgttc 2339581 acaagcagaa ccaaatgctc cgccgcttcc gtgccgattg ttttctgctc tgtttttgca 2339641 aggttgacag taaagtctgt cgtttccttt gcatttaatt ccttcgcctc catcataaac 2339701 gcgtgcttct ttaacgcttt cgtcagcttt tttcgctcat caagcttttc atacggagca 2339761 agcaggacaa agactgtgta aggcgcaggt gattgtatat atgattcaag cgcactgacg 2339821 ttgtgctcaa ttttttcttt tttcttttca cctgttaaaa aatatggatt tttcacaatg 2339881 acaagacgcc gctcccccat aaacggaaac gtttcagcat ctgcaatcgc ttgatccagc 2339941 gggtcctctt ccagatcaaa aacggacaga ttgaaatcct ttgtctcctg atcaacgacc 2340001 gtctgtctga tcctgctgac ggtttcttgc agcagatatg tctcttttcc gtataaacaa 2340061 taaaccggat ggacctctcc ttttttcagg cttttccaca catcaaatac cattgttgta 2340121 cgacttcctc tctttcatca tccccttcta tcctaaattg agtttgcaaa atagtaaaga 2340181 ggaagcctga ctgctgcttc cccatttata ttaaacgcct gttcgcaagc ccccgggaca 2340241 gcttgtaaaa aggcgataat caccagaaca gaaaacgtta ccttagcttc tagatttttc 2340301 aaaacaattc cattatactt aagtcagtca ggagggataa agttgaatga ttttgaaaaa 2340361 aacgttcaaa gcaaacgaaa tgatgctgta gattcagctg ttggttttgt tgtgtccttc 2340421 ggatttttcg ccttcttgtt tgtcatggca acggttattc acctagttgg ttcataacag 2340481 cgactgcccg ggctgctgat ttctcggcag tcttttttag ttcgtctctg ttatatctga 2340541 tgtatcatat ggaggataga cagaaaaggt tccaactctg tttttgtatc tatattggat 2340601 cgttccgttt tgatctgttc gcagcacgcg gatagaatgt ctctgtaata gttgcagaac 2340661 tttttgatga ggatgatggt accgattgtt tttcccggct gagataatgg ccgttttcgg 2340721 ctgaagctgt tggatgaatt cttcaccggt agagcctttg ctcccatggt gccccacctt 2340781 taacacatct gcttttatat tcggaaacac gttcatcacc tcttgttccc cttctttctc 2340841 cagatcaccc gtcaagatcc agctcatacc gcccgtctcc atccacagaa cgagagatga 2340901 attatttttg cttgccggat caggtgcttc cggtgacagt acatggaact gcaaatcctt 2340961 tatttgcaac acatcgcctc gcttcacctc ttcaattgcc actccctctt ccctggctgc 2341021 ctgcagcact ttctcatctt taggttcaga aacgaaccct ttcggaatca cgaggcgctt 2341081 tactttatga tgcttcagca gaatctccgc ctctccgata tgatcttggt cagcgtgcgt 2341141 cagaattaaa gcgtcaagct gcttgattcc cttagcagtt aaaaacggaa tcagcacctt 2341201 ttcccccagt gaaaacggat gctgtttttc gcgccaaggc tctgacgagt aagacaaagt 2341261 gccgccggta tcaattaaga cacgaccccg ctgatgcgga gcacctacaa acatgctgtc 2341321 accctgtcca atatctatca tatccacttc tccttcggaa ctaagacacg gatatataaa 2341381 gagcagaaac atcaccgtgc agcaaatgcc tccggttacc atcaactgcg acaaggagcg 2341441 tttttcaatc gccataagca ataggatgat cgtgactgtg aataaaaaaa gcaaaacagg 2341501 tgcaggatgt gcgatcataa tcgtgaacac atcaacatct gcaatgtttg tgattaacct 2341561 attgatccag cttatcaata aatcaaacca gctgaaaaac aatctcccaa acgaagcgga 2341621 aagacttaat agaagaacac ctgctacagc tcccggcaaa atacagaagg tataaaatgg 2341681 taccatcaac atattcatcg gtacgctgat gatagaaaac tgatgaaaat gatataggag 2341741 aatcggaagc gagcccagct gagcgatgag tgatacaatt gtcagctgcc ccaaggaggt 2341801 tttaacctgc tgaaaaatag aagaggatag aattaaagaa aaactgacgg cgaacgatag 2341861 ctgaaaaccg gcttcaaaga gatgataagg attgaagagc agaaggacga tgtacgaaag 2341921 gcaaattgca gttgcagagc ggacacgcca tttgacaaga cttccagcta agtaaacacc 2341981 cgacatgaga gcggcgcgta gcactgaagg agcagcgccg gtcaacatca catagagcgg 2342041 cagaaataac agcaacagaa ttgacgcctt ttctctagtt ataccaaggc ggatcatgat 2342101 ataaaacaaa cctgctgtca aaatccccac gtggagtcct gatattgcca agagatggac 2342161 aacaccaagc ttttgatacg cggtaagcac ttcatcctcc acgtaaaatc tgtcaccaac 2342221 tgtaagtgcc tgtacaatcc ctgtcgaatc aggaggcaga aggctgtttg tgaatgatat 2342281 gatatgtttt ctcaagctga gcaccttgta cttgaaattt tcaggttcgc tgcagttttg 2342341 gatagacgtg acagagtagt tccaatgaat atgctgccga taaagatact cgttataatc 2342401 aaatgcaccc ggcacagttg cgtgattcgg ttcttccaat gtaccagtca actcacatga 2342461 cattcctggt tctatgtata acagctgttc tttttcacca gcagactgaa tgcgatacgc 2342521 agcagcccat ttttccttat caggtgtctc aaccatcata gacatacggt cgccgtcaat 2342581 tttgggaata gtgtcaatca ctgccttgaa ttgataggtt ccctgccgat aggaagagac 2342641 attctgagaa tctgtgactg catacagtac aaaaaacaat ataaaagaga agaaacaaac 2342701 aataataaga aaagcgtgcc tcgttttgat taaaatgatg aggagaaaga ggatgaaaag 2342761 aaaaatagcg gggaaataag cggcggcagt aattccagcc gttgccgaag ctgccgccat 2342821 aggcaataat aagcgcgaat tacgcattca tcacacgtag ctcgtgaaaa gtgtattcgc 2342881 ctgttcatgt atctttttca attcttcctc cgctaaaccg gcatcagcca atttccctat 2342941 tagacccgct acaaatgaaa gcttttctct gtttttcaga tcaacgatca tttcatcgag 2343001 ttcaacctgt tcaacagtta cacccgcctg ttcaaataat tcctgcgcat acggatgtgt 2343061 tttgtaatcc tcagcataat aaaccgtttt gataccagct tgaataatag atttgcagca 2343121 ttgaatgcac ggataatgcg tcacataaat ctcggctcca tcagtcggca ccccaaactt 2343181 agagcattga agaatcgcat tcatttcagc gtgaatggtt cttgcgcaat gatcatctat 2343241 cattaagcat ccttcatctg cacaatgtac gccgcccgcg attgacccat tgtagcctcc 2343301 tgctatcatg cgtttgtctc tgactatagt agcgccgaca gataatctcg gacatgtgct 2343361 gcgcagcgcc aataaatggc tttgagccat aaagtattga ttccatgaaa ttcgttccac 2343421 gttgttccct ccaaatgttg tgttgcctga cctttagttt acctatcata atgcatgacc 2343481 gtcaaatcac tttactgtaa tggaagactt tattttctca aatgactttt cacctattcc 2343541 tgaaacctta gtgatatctt caattgtttg gaaacgaccg ttttcctccc ggtatgcaat 2343601 aatagcttca gctttggatg gccccacccc tgagatgcct tgtaactcct ctaaggttgc 2343661 tgtattgata ttcaccagcg ctcccttccc tccatcgctt tggacagacc ctccgccacc 2343721 ttgctgcact gctgtttcct ctcccttttt cgggatgtac accactgtcc cgtcctgcag 2343781 aatctccgcc aaatttactt gcgcttcgtc tgcttgttca ctggtcccgc ccgctttctc 2343841 aattgcctga gatactctgt cccctgttcg catttcataa acgccaggat gctgaacagc 2343901 acctttgatg tctatcacaa ttgtttcgtt tgactcgtcg ttgtttgctt cctgctttac 2343961 cactgtattt tctgtctctg ttggtacagc ttgcttcacc ggctctttat ttttccctgt 2344021 ggccagaaag atcataatcg ctgtgaaaac agccgcagaa gccgctaaaa taattgcttt 2344081 cttatgctga ttcaaccaat tcatcgtgca tgttccccgc tttcgtcata ttttattttc 2344141 ataacacata tggtttagag gataatagct caaaggaggg gaaaccattg aagataggct 2344201 ttatcggcac aggaaatatg ggtacgatcc ttatcgaatc atttattgaa tcaaaagcgg 2344261 ccgatccctc aaacatgaca atcacaaacc gcacaattga aaaagcgttg cacataaaaa 2344321 accgctacaa cagcataaac gttaccgaaa gtctcgaaaa gctcgtttct gaaaacgaga 2344381 tgatttttat ttgtgttaag ccgcttgata tatatccttt actggcaaga gcgttacctt 2344441 atttaagaaa agatcatatt ctcatttcaa ttacaagccc cgttcaaacc gaacagctcg 2344501 aacaatatgt gccgtgtcaa gtggcgcgag tgatcccaag tattacgaac agagcgctgg 2344561 caggtgtttc tctcgtcact ttcggcacaa gctgcggcga atctgcaaaa gcgaaaatca 2344621 atgagctgat gcagcatatc tctcatccgc tgcaaattga aagtgacatc acgagggttg 2344681 catcagacat cgtaagctgc ggccccgctt ttatgagcta tctgattcag cggtttatag 2344741 atgcagctgt ttcggaaaca tcagtgtcta aacaggacgc gattttgatg tgtaaggaaa 2344801 tgcttgtcgg aatgggaaaa ctgttagaaa ccgaattgta taccctgcct gcattacagg 2344861 aaaaggtttg cgttaaaggc ggtgtaacag gagaaggcat taaagcgctg gaaagcggtg 2344921 tgcaggatat gtttcaccgg gtatttcaaa atactcatat gaagtacgag gaggatattt 2344981 ccgcagtgaa aaagcagttt catgtgtaga cgagtatgtc atacgttcgt ctgtactgca 2345041 aaagcataaa aaagcatttt aaaaaaccat cgttttagga aacgatggtt tttgatttct 2345101 gcgccttgaa aaagaggcgt tctgattgtg ctgatggctc ggtatccgta aaatcagctg 2345161 tcacgcgatg gagctgaaag ccgcagttct taagcatttc ttcgtattct tccaccggga 2345221 acgttctttg ctcgtgtgtc tcatcaaaac gatcatacgc ttctccgttc cacacaaaaa 2345281 acgacatatc atgaatgaca gaaagctcgt cacttccggc aaagctctgc caaatatagc 2345341 tgatatcttc gtcctggtca gcaaatgtgc tatccggaaa gacttccgca attttaaaag 2345401 atgaatgaac atcaaacagc aggatgcctt caggctttaa tacccgaaaa acacttttaa 2345461 aggtttcgat cacatcattt tttgttttta aataatttaa tgagtcacag catatcacaa 2345521 cagcgtcaaa ttgaccgtca aagccggtaa tctctctcat atcctgctga agaaataaaa 2345581 taggctggct actcgatacc ttttgctggg cgaaagaaag catctcttcg ctgagatcga 2345641 tgcctgtaac ctcgaagcct ttttcggcaa gccggatgga gatttccccc gtgccgcatg 2345701 ccagatcgag aatacggcct ttttccggga gagatgcttc aatccatttt gtccattgat 2345761 cgtaaggcgc gtgtgacatt agctcgtcat acacgcttgc aaagccttga taaatcattg 2345821 attcattcca aagtcaagat ctgcgagcgg agcgtctccc cacagctttt caaggttgta 2345881 gtagcttctt tcatccttgt ggaagacatg gacaactaca tcgcctagat caacgagaac 2345941 ccatcttgct tcatcaaagc cttccatctt tttgacttga atgccgtttt catcagcttg 2346001 atccttgatt tcacgggcaa tcgcctgtac ctgtttatct gaatttccgt ggcagatcag 2346061 aaaataatca gcaaccagag aaataccttc catatccagt gctaaaatat cctctgcccg 2346121 tttatcatcg caagccgcag ctgcgatctt taaaatggac ttttggttca ttcacaaatt 2346181 cctcctgttc agctgccaga cacaagccag ttatacgtta aaaatgtgtc tggaaaaacc 2346241 ggttgatttt ttttcataag aaaaaccatt gtatttttaa tggactgaat cagcgcttga 2346301 ttcaaatctg tctcagcaag cttacgcacc tcatcgacac cgggaaatgc ccggtttggc 2346361 tcaatgtaat cggcaacgta aatgactttt tctaaaagtg tcatgccggg gcggcctgag 2346421 gtatgatacc taatggcgtc aagaatgtct tcatcttgaa cccctgcctc tctttggacc 2346481 aaataagcgc cgaccggagc gtgccagagc tccggattat gatccaataa atgcgcaggc 2346541 attttttcac gcgcaataat ttgtttcatt tcttctttcg ggcggaattt ggcgtaatca 2346601 tgaaagattg ccgctatttc cgctttttta gaatcggctc caaaacgctc cgcaagttcg 2346661 atcgccgtgt tcatcacgcc aaccgtatgg atatatcggt gttcggtcaa ttgctgcttc 2346721 acgcatgcaa gtgcctcctc acgattcata taaaccattc tcctctacat acttcttcac 2346781 tttatcaggg attaagtagt cagtgggctt cttgctttta aaccgttccc ttatcatagt 2346841 tgatgatacc tcaaattccg gaacgtctgc aaagagaagc ggataagggg tttcaacatg 2346901 aaaaccgggg cgctttactc caataaattg aatgaggttc agcagctcgt ccagcttata 2346961 ccatttcggc aaatattcaa tcatatcagc gccgataata aagaacagct gatcatttgg 2347021 ataacgctgc ttcagtaaag aaacggtatc aaaggtatat gatggccctt ctctttccat 2347081 ttcaacaagc tccagcttaa aggacggatt agattgaatt gcaagcttta gcatttccac 2347141 gcgatgaaag ctgtcggtat agtcttcgtt ctgtttatgc ggcggaattt gattaggcat 2347201 aaaccaaatt tcatcaagcc ccgcctggta cagcacctca ttcgccatta agaggtgacc 2347261 attatgcgga gggtcaaacg tgcctccgaa aattccgatt ttcttcattt caaccacctt 2347321 taaggaagct cgatttgttt attttccttt gattccttat ataacacaat cgtattgccg 2347381 attgtctgca ccaattgaga gcggcttcct tttacaagag cttccgctac atcgttttta 2347441 tcctcttcgc aattctgaag cacgctgact ttaatcagct ctctcgcttc aagcgcctca 2347501 gcaatttgtt taatcatgtt gtcgtttact ccgcctttac ctacttgaaa aatcggcgtt 2347561 aaatgatgcg cttttgaacg caaaaaacgt ttttgtttac ctgttaacat tctgttcctc 2347621 ctaattttcc tattacaata gatctcattt tttcaatatt aggctcttgt ccagtccaca 2347681 attggaaaga caatgctgcc tgttcaacaa acatgcccac accatcgagt gttttcaagc 2347741 ctttttggct tgcttctttt aaaagtgccg tctgtattgg attatacacg atatcacata 2347801 cgacggcact gctcgcggca cgctgtaatg aaagcggcac atcgtccacg ttcggataca 2347861 tgcccacaga cgttgtatgg atgataacat catactgctc aagacgttct tctgcttctt 2347921 ttatgcttaa tacttcttta ttgtgaaacg agggagtagc ttctgtaagc cgctttgctt 2347981 tttctaacgt ccggttgcaa atgtcaaatt ttttcggggt atttcggaca attgttgtaa 2348041 aaatggctct cgccgctccg ccagcgccga tcattaagaa tgacagttca gagatgggct 2348101 tgtctaatac cttcattaat gacttcacga agccttcccc atcggtattg tatccgacaa 2348161 gcttatctcc ctctcttctg accgtgttta cggcaccgag cacttttgca ctctcatcaa 2348221 tatgatccaa ataatccata atggaaacct tgtgcggaac agtcacattg attccttgta 2348281 cgcctagagc tcttattcct tttaccgcat cctccagatc attctcttct accttgaagg 2348341 catgataatg tccgtcaagc ccgaggtctt tcaatgatgc gttatgaata tcaggtgaca 2348401 tagaatggcc aataggattt ccgataaccc cgtacagctt tttcatacac ctctcccctt 2348461 ttcttaaatt aatgaacgcc gaacaaatac atgaacgcct tttggcgcgt atgcagttac 2348521 ctttttatca gcgtcatgga cagtaaccca gcctaaccca gagaaaacga tatctgtctt 2348581 tttgtctttt atcgtaaacg tatgggcgac caattcagga aactcatcca tttcatcttt 2348641 acccggaggt gtgagcaatt cccctgcatg cttttcataa agcgcgtctg cattttcaag 2348701 ttttgttcta tgaatcatca gctcattcgg catatagcaa ataaaaggag atctttcccc 2348761 agacacataa tcaaaccttg caagtccgcc aaaatacagt gtttgctgat cattaagctg 2348821 gaatgtgcga ggcttcagct cctttttagg agataatatt ttcaggtcct ttttattgac 2348881 ataatgcgcc atttgatggt tgttgataat tcccggtgta tcataaagcg atgaaccgtc 2348941 atccagcggg atttcaatcg catcaagggt tgtgccagga aattgggatg ttgtaataat 2349001 atcttcttca cctgacactt ctttaataat ccggttaata aaggttgact ttcctacatt 2349061 tgtacatccg acaacataga cgtcttttcc gttgcggtaa tgctcaatcg cgtcaattac 2349121 ttctctgatt ccctggccgc gacccgcact gaccaaaaat acgtcaaccg gttttaagcc 2349181 aagctctttc gcttcacgct tcatccattg gatcagacgc tctcttttca gtgacttagg 2349241 caaaatatcc gctttattgc caactaataa gatagggttt ccccccacca agcgctgcag 2349301 cccattaatc cagctgccgt taaaatcaaa aatatcaaca atttttacga ccagagagtc 2349361 cgtttctcca ataccgtgaa gaatgttcaa aaaatcatca tcagttaagg agacatcttg 2349421 tatttcatta tagtttttca gtctgaagca acgctggcaa atcacatttt ctttcgtaag 2349481 cgatgcaggc ggcgcgtacc ccaaacctgt tttgtcctcg gtttggatcg taactccgca 2349541 cccgatacaa acaacctttt ccatttctta ctcctcccac tgaatgtgcc cttttcgttt 2349601 gagagcactc agtattctgc gttcgacctg gcggttaaag cgcgtaatga atccgtcaga 2349661 ggaagcgact ggcacgacca aaatcgtatg gtagccgttt cggtttcccc cgagtacatc 2349721 ggtcagcagc tggtctccga tgacaacgca gtcctctttt ttcagctcca tattgcgcac 2349781 cgctctatta aaggctttac ccatcggttt tcttgcttta tagatgaatg ggattccaag 2349841 cggttctgag aaaagtttca ctcttctttc gttattatta gagacaattg tcactttaat 2349901 gccgtgttcc ttcatttctt caaaccactc gatcaatcgc ggcgtcgcgt tcggcctgtc 2349961 ccattcaaca agcgtattat ccaggtcagt aataattcct tttacatttc gttcctttaa 2350021 tttctcaggt gtaatatgaa aaatattttt tacaaactcg tcaggtaaaa aaaacttttt 2350081 taacaaaacc cgcacccttc cctttttctt tctttcaaaa tgattgtcga aaaaaatcga 2350141 acttgcgcct aaagaaaaac tgagcaaaaa aatttcgaca aaaattgggt ttcttcacca 2350201 ggtgtggata aatttacaca cactatccac tcttattaca tcactcttta gacaaattat 2350261 aaacacgata ctcacaagtt atccactttt tggtgtggat aacagaacga ttgttcttat 2350321 atgcatttca tggtagatta aagataactt caacctcaga tgaatgcaac ttatcattgt 2350381 atgcgttaaa atcatgaatg attccaactt ttaaggaggt gcctctccca ttaattgggt 2350441 tcctagcatg agaaaactgt ctgatgaatt actaatagaa tcttatttca aagccaccga 2350501 aatgaattta aaccgtgact ttattgagtt aattgaaaac gaaataaaaa gaagatcgct 2350561 cggacatatt atttccgtat cttcttaata ggaatttgtc tattttttcc gggcgtattt 2350621 ccttttttta ctcagatgac tgatattata tcactttggc tgcgcgcttt actactattt 2350681 tcagcaaaaa acacccctaa aaagaggtgt tttaaagggc cggttattat gctaaccagt 2350741 atatgccgcc cacaacaagg agaacaacaa ctaaaacaac aataaaagcg tatccatatg 2350801 ctctgcctgc gccatacatg tgaagcgcct ccttaataag gttttataac agcctatgta 2350861 ggagaaataa atcggactag gcggttgtcc ggctcaacgc tgcaggatct gcccatcttg 2350921 tattccttca tatacgatcc ttgccccttt aggtgtcata tgatttccag aaggatctat 2350981 aagaccagat tggataagcg cttcatcagt tgcttttccg ccgtctgctt ctataaaatg 2351041 cttccagtta tctacaagag ggacatccag gcgcttcgac acatctcttg taatatcgtt 2351101 atatgagttg tgccatttcc ttgctccgcc ttttggttca aaagcagctg cttgatatct 2351161 ggaatagtaa aacaaatgat gcttcccatt accttctata attgggatac acgtcattaa 2351221 gattggcttg atcccgtgtt ttctgctttc ttcaataaaa taaaccagat tttctctaaa 2351281 acgctgcttc gacactctcg gtttcccctc agtcagtatg gcagcgtcat tggttccgaa 2351341 cataataaac aaatacttcg gtttttgatc cagcacatct gtctgaaatc ggagacgggc 2351401 atcctctgtc gtctgtccgc cgattcccgc attgagtata tcaaggttac cgcgctcagc 2351461 tgtttttaat atattgaccc actgctgtgc ttttggataa tcgcgataat cccaattaga 2351521 gccacgcgta ttactgtcac caaatgctac aacgtcttcg tatccccttc cctcgcatcc 2351581 tgctgtaacg aacagcagaa ggaaaaggat gataaaatgt ttcatcttta cacccccaaa 2351641 agcctcactt taatgttata cctctgtttc tcttcgttca atgaagagtt tttcgctatc 2351701 actgtttttt cctatagtta acgtgtcccc ctcagtgaat atcattctgc tttcattgcg 2351761 gcgcagctga tgatttttta aaattccctt ctttccaatc tgaaaaacac acaaaccaaa 2351821 gaaaagaaaa taacctgaat ccgcactgga aacaggttat ccgttaaatc ctgcatttac 2351881 tttaacttcg atttaagctt ggcctttgtt tttggcccat aaatcccgtc tgcagttaat 2351941 ccgttcatga gttgaaaacg cttgacggca ttcgctgttt tcggtccgta aactccatct 2352001 atgccattgt ttttggctcc cttatcaggg taaaagtgaa gtacagctaa agccttttgc 2352061 agctggagaa tgtttgtgcc ctttcgataa ggcgaagtga gctttataac cccagacggc 2352121 agaggatatg atggtgaagt ttcttttgga ggtgtatccg aggaagaaat tccgtttaga 2352181 aaagagttcc agtggtccaa gagtttccgc ggacattctt tcccggacca ctttttgtgg 2352241 ggaacaacac gatttaacgg aatattgttt tccttcatca gctttctgat cagccactgg 2352301 gcatttgatg ttgctttttc aaaatcgccg tcagcatttt cacagatttc aatcccgatc 2352361 gatttgcggt ttcctgtccc gtttgtaccg tctcccgcat gccagccgtt ttcatctatc 2352421 gggagatgct gataaatgac tgaatcgtca actgtaaaat gccagctttc ggatgtgttc 2352481 gggtttttca caaacttggc gtgcattttc gcatcagcgc ctttggctgt attcgctgta 2352541 ttatgcaccg taatataagc aggcgccatc gcatagccag gacgattatc atttgatacc 2352601 ggtataaaat ccttttttat ggttaccatt tctatccctc cctattaata agaatgcaga 2352661 aaacagagag atggacagcc ttttttatga ggtaaaaaag aattgtgttc ttaacctggt 2352721 tttcagttga acagctgaaa tggcaccagt tatactaatt tagatgacgg aggttttgac 2352781 tcctgacatc acctaagttg ggagtgacca tagacatgtt aaaaaaagta ataggtatac 2352841 ttgtgattat cgctatcatt tcagttggtt tttttcagaa agaagcttgg cttgatgcaa 2352901 tcaaagcagg agggatgttt tccgttttat ttagtatgct gctgattgct gccgatgttt 2352961 ttttcccaat agtgccgttt gctttgattg ctgctttaaa tggcgcagtg ttcgggactg 2353021 caaatggaat ttggattaca ctgaccggct caatgcttgg tacaatattg ctgttttttc 2353081 tcgccaggta cagttttaga gattgggcca gaaaaaaagt tcaggcctat cctgccatac 2353141 aaagctacga ggcttccttc aacaaaaacg cttttaccgc tgttttatta ggaaggctga 2353201 tacctgtcat accttcactt gtaatgaacg tgatctgcgg gctgagccag gttcgctggc 2353261 atgttttttt ctttgcgtct ttaataggga aaatccccaa tattgttgtt gtcactattg 2353321 caggtgccaa tttcaccagc aataaattat tgtctatcag catttacggt acatatattc 2353381 tgatcatcat gctggtcatt tataaaaagt tccctcatct tctgaaggtg ccaaaaaaat 2353441 aaggaggctt gttggccccc ttactttttt tctgtcgcat ggcctccaaa ttcatttcga 2353501 agcgcagcaa ccacctttcc tgtaaacgta tcgtctgtta aagaacggta tctcatcatt 2353561 agtgacatgg cgatgaccgg cgttgccgtc tgcagatcaa gcgcggtttc caccgtccat 2353621 tttccttcac ctgaggaatg cataatgccc ttgatctgat ccagtttcgc atccttagcg 2353681 aaagctcgct cagtcagtcc cataagccaa gaacgaatga cagaaccatg attccacact 2353741 ctggcaacct tctcgtagtc aaaatcaaat tggctgtttt caagcacttc gaatccttca 2353801 ccaatcgcgg ccatcattcc atactcaatt ccattatgga tcatttttaa aaaatgtccg 2353861 cttcccgctt caccagcgta tagataacca ttttcgacgg cagtatcacg aaaaagcggt 2353921 tccacaatct cccatgcttc atgatcgccc cccaccataa aacaggctcc atgccgtgcg 2353981 ccttccattc cgcccgacgt tccggcatcg agataatgga tacccgcttc tttcatttga 2354041 ttgtagcggc gaattgattc tttataatga gagtttccag cttcgataat catatcgcct 2354101 ttacttaata aaggtgatac atcacgcaaa acagcatcga caatgccatg cggtaccata 2354161 acccatagga tgcgcggcgg gtgtaataaa gaaatgaact ctttaagatt tgttgtcccc 2354221 tcagccccgt atgctttcag ttcatcaaca gccgcttgat ttacatcata tccaaccact 2354281 tgatgattgc ggtcaatgaa ttgctttcct atgtttatgc ccattttccc taagccgatt 2354341 aatccgattt tcatatctgt tcctcctgat tgtctaaaaa gcctttactc tttatgttcc 2354401 ctatggattg tattgtgata cgcagaaaac aaatggggct tacatcgtct gcgcatgtaa 2354461 attttatttt tcatgaccga cggcgcctgc cagttctatt actgaatctc tttatatcca 2354521 taattatcgc tttatccttg atttaccatc agtttaagtt aaaatatggg aaggaattcg 2354581 attttttcag taaaaagaag gtgacatgtt gcagaatcaa tctcatactc ttattggagt 2354641 tacgaaaacc gctgtattct ttttatacgc tgcacttgca atcatcggtt ttgcaatcgg 2354701 gtattttatt ccgcagattg cgaaatgggc attatccctc ccctggatcc ctcttgaagg 2354761 accacttcgg ctcattacct cttttcaggg atctacagct tcatttatca ctgctcttct 2354821 cggtatgtgt gcggggattt ggttcgctca ttctgttatt gcaatgctgc tgtctgtcaa 2354881 aattacagat cacacagtgg aattcatcaa aggaaaaaaa gtgcaaacaa ttcattccga 2354941 tgacatcgct cttgtattta tggatcacaa acggcttgtc ctcctgggaa cagccggata 2355001 tgaattggta cgggaagaaa ttgatgaaaa accagtaaac gttgagaagg cctttagaca 2355061 gcatcattac gaatgggcaa cagatggtga tccgtttaaa gatcaatttc gccgatggat 2355121 tcctgatgca ccagacctat cgcaaggcgc ccatgcctta ttaaaagctc gtcacaaagc 2355181 actgcaggac gaagaaaaag acgatattga agaattccgt ctcgaactgg cacagctggg 2355241 catcgttgta cgggacgaag gcacacgcca atattggcga aaagcagaaa cctatccccc 2355301 gaaaattcag ctcggcgaag gattgtaaca acagaggctc aagaaagagc ctcttcttta 2355361 ctactgcaca ataaacagca ctctggtacc gtcaggatag ctgctcattt gattccctac 2355421 ccacgagccg gcgccgcgat tatcagaagg cgtcacatat cggacatcag cccctgcacc 2355481 gccttcctcg cagaccgcca tcggccactc atcccggtca tagcccggct tggtcgggat 2355541 tccctttaaa gattcctccc gccttttgtc tgctccatct ctgtcaatgg tacaaatatc 2355601 tggatgtccc tctgcaatcg catccctaat atgactgccg gtttccggat aacgagacag 2355661 cggaaaatat aacactttgt catacgaaga tgcgccttgg atctgttgcg gaaccattaa 2355721 acaaagaaga actgctgcag caagaaacag gcctgccatc cattttttca tccccatccc 2355781 cccatacctt tgttcatttc aatgtatggg cgcttgatga agaatatttt taacatttga 2355841 agttagtatg ctgcttacca aagccggact cccccgcgag aaatttcccg gtacagacac 2355901 agacagcctc ccggtcacat acatttacat ataggctttt gcctacatac ttttgtggag 2355961 gtgacgatgg tgacaggtgt tttcgcagcg ctcggctttg ttgttaaaga gcttgtcttt 2356021 ttagtatctt acgtgaaaaa caatgccttt ccacaaccgc tctcaagcag cgaagaaaaa 2356081 aaatacttag agctcatggc taaaggggat gaacatgcca gaaacatgct gattgagcat 2356141 aatcttcgct tggtcgccca tattgtgaaa aagttcgaaa atacaggtga ggatgcagag 2356201 gacttaatct ccatcggaac gatcgggctt attaaaggaa ttgaaagcta ttccgctgga 2356261 aaagggacaa agctggcgac gtatgcagcg aggtgtattg aaaatgagat tgtaattaca 2356321 aaaggggggt gcatacaccc ctctttaata cgtttcaata tatatggtgt cagaatccac 2356381 aatggtaact tctttcacga taaagttaac aattgttttt ttatcttcaa gagttaagtt 2356441 atctgcaccg attgattgaa aatagtcgat ggctcttttt agagcatttt cacttgagct 2356501 cgtatcatct aggactttca tttttgactg gatttcgtta cacttttcag taagctgatt 2356561 ttgctttttt tgcagttcaa taatttgtgc tttgatttca tctatgtcta aatcatcgtc 2356621 atcgcttagg ctgattagcg ttaaaagacg cttgcggcct ttttttgttt tctctatctc 2356681 tttttcaata agttctaatt catcagacag gtgatttgat tgttcagcct ctttaaaaga 2356741 aacatacttt tgaggatttg tgatgaattt aaaaatttca ccccatacat gccggttcaa 2356801 tttattctca gacatttctt ttccgcagcc gcggtccttt gcgccagaat aatttttccg 2356861 gcaagtatat acatagtagt ctttaccatg tgattttctt ttcttccctg tcatggtatt 2356921 tccgcatttt ccgcatctaa ccaaacccga taacaagtaa ttgtgagggc tgatactcaa 2356981 gtgttttctt ttactttgac ctaagagttc ttgagcataa tcccattgtt cagctggaac 2357041 aattgctgga attgtcacag tgatttgttc ttcttcaggc cttattttaa ttatagattt 2357101 gttccctgcc tgctttgaaa cataggaacc ctctgtatca tatttatact gtctatgttc 2357161 acccttatag gaagagttca ttaatatttg ccgaacaacc tgcctgtgcc atactttggc 2357221 gccttttttt gttttaaccc ccatctgagt taaatgtaga gcaataccat ttactctgcc 2357281 gaaaaaaggg cttttatgat cggtgaaata gttaaaaatc atccgaatga tttttgcttc 2357341 ctcttctaat atctcaagag ttcttttctc tttaacaaat ttatagccat atagtttaga 2357401 atctttaatg atcatgcctt ttttcatttt ttgaagtcgg ccgcttgatg tccgttcttt 2357461 gattttggct ttttcaaatt ctgagattgc cccgcgcatt gcgaaaaaca attgaccttc 2357521 tggagaattg gcgtattcac catttacaaa aatcaaaggt atgtttcgct ttcgcaattc 2357581 gtcatcaatg attagctgat tcattaattt ccgagaaaga cggtcaggat cgtaacaaat 2357641 gacttgactt ataagtccct tgcttgcatc ctccctcaag cgattcaaag ccggacgttc 2357701 taaaagctct cctgaaaatc cttcatctgc atacttcagc acatctttag tccctgcttt 2357761 ctttatacag gcctcgattt ggctgtcgat gctcgatccc ttgatcgctt gttcctcggt 2357821 cgataccctt acatatattg ctatcaccct gaatctcctt cctataaagt tttattaaat 2357881 aatgatagca atcgttaatg catttgtcag cttgcggtcc ctcgatgatt atcactttca 2357941 taaaatgcat caccccttgg gtaatgctat gtaacagctg tttgtccaaa tgaggagatt 2358001 ttaaattaaa ctatagtgtt attaaacgtt tcaatgaata tgcaaaaaat ttaaaaaaag 2358061 ttgttgtgac ttttctacac tcctttaggt cctcaataga aaagatttta ttttctatgc 2358121 ctcaacattc gcttattata gttttcaatg atttattatt atttgagagt acaatggagt 2358181 agtgtttttc attgttagat agttaatgac atttcactgg tgtcaagttc gtatagctag 2358241 acattaataa aaaaaggaca catataaata tgcatccttt aacaaaagag tttatttatt 2358301 tccctgtttc agcaaattcc ttcaacctat tccctatttc atcacgaact ctttggaaaa 2358361 acgcccattt ttcttcttct gtcccttgtg ctcttgccgg atcatcaaaa ccccaatgct 2358421 cacgttttac atgtggaggc gtcatcgggc atttatcagc agcatctcca caaagcgtaa 2358481 caactaaatc agcattgttc agaatatcag aatcgattat atctgacgtt tgattagaga 2358541 tatctatacc aacttccttc atcgctttaa cagcattcgg atttaatcca tgtgcttcta 2358601 tccccgcgct atacactttc cactcatcac ctaaatattg tttagcccat ccttcagcca 2358661 tttggctccg gcaagagttc cctgtacata aaaagtaaat gattttattc tccatatatt 2358721 ccacctctac atcgagtgac ttccaaagta ttttcgttga aaccataaag caaccttaac 2358781 aagtgctatc atgactggca cttctacaag cggaccaatt acggcggcaa atgctgcacc 2358841 cgaatgaatt cgatatcaag cttcgcactt aaacacagcg gaatttataa tatatgcttg 2358901 gacagccgta aaagccgaac tgaacaatgg tatgattttg ctcatgaatt ttgccatata 2358961 tatagacatg aaggcgataa aaaaacaatg cctgcaactt ggactgatta tttggattgg 2359021 cagtccaatt attttacata tcacttttgc attccaactt gcatgttgcg taatatcaac 2359081 cttccgtaca tacaatcaca tgcaattgaa aatgtagctt ggttatttaa ggtatcccct 2359141 tcattcgcta agaaacgttt aagcatttat tacaggaaac tgactcaaca tttatttagt 2359201 caaactgtta cgggaaattt atgccccccc tttttgtaat gaataatgaa atcctcatgc 2359261 atttgcgcgc attgaaaaaa acaaaaaaag acgtctccct tcacgatccg atcgggcagg 2359321 ataaggaagg gaatgaaata agcctgattg acgttttgaa atcagaaaac gaagacgtga 2359381 tagatacgat ccagctcaat atggagcttg aaaaagtgaa acaatacatt gacattttag 2359441 atgaccgtga gaaggaagtg attgtcgggc ggtttggact tgatttgaag aaggaaaaaa 2359501 cgcagcgaga gattgccaaa gaactcggta tctcacgcag ctatgtatcg cggattgaaa 2359561 agcgggcgct gatgaagatg tttcatgagt tttatcgggc agagaaggaa aagcggaaga 2359621 aggcgaaggg gaaataatgc agaagaagcc ggatctcata ctccggcttt ctctatttga 2359681 aagagttatg aaaatcattt ttttcatcgc tgataagctc tccgagaaag acaggcagga 2359741 tcgtaacaaa taacttgact tataatcctc ccgcaggcat tcaaagccgg acgttctaaa 2359801 agctctcctg agaaaatcct tagatcggta tacttcagta catctttagt ccctgctttc 2359861 tttatacagg cctcgatctg gctgtcgatg ctcgatccct tgatcgcttg ttccacgata 2359921 tattgctatc accctggatc tcctgcctat aaagttttat taaataatga tagcaatcgt 2359981 tcatgcattt gtcagtttgc agtccctcga tgattattac cttcataaaa tacatcaccc 2360041 cttgggtaat gctgcgtaat acctgtttgt cctaatgagg tgattttcaa tgagtatgaa 2360101 aacaaataaa aaaaccgatg gtttgtacca tcgatctgtt ttctatatca ctaggccctc 2360161 aatatagtaa atctagctca ttggttatga aagcttattt tcattacaca ctatatattc 2360221 atttgttatc atttctatac gtttatatca attatggtaa aaaatggtta caaaaaccca 2360281 ataaacgtcc aacctaactt tttcatctta tttattaaga attttaacct cttccttgtg 2360341 aaataaagaa gcgattttca tctccaaaca gttaatgcta tttcatcggg acatgtctgt 2360401 taaagtagcc aataaataca ttcggatatc cacttacaac cacgattcaa tttgatccac 2360461 tacagatttc tgagctgaca ttaaacagat agagttataa aaatctgtac cagttccctt 2360521 tcacaattag gacatttcgg cggcgtttcg gcataatgcg aactaattta ttaatgttca 2360581 acaacagaat ttcgtctatt ggcaataaag aatccacaaa tcattgcaag aatggccatc 2360641 gcccaccaga acgttgagat cgcctgatca tgatcgatga taatcaaacg aatgacagct 2360701 gtgatgccaa tataaatgaa gtagcgaagc ggaaaatgaa agtctgattt gaagtatttg 2360761 ataatcaaag caatgaactc aaagtacatg aagaatataa gcagttctcc aagcatctca 2360821 taatagctgt ccactttgtt gaacagtgac ttgtatacga atagcacaat gtaccaagtc 2360881 tcgctgatca gaagtgcgct taaggctaac gccagaaaga acagacagac gttgagaagc 2360941 gcttgtaaca ggtaaggcac ctttttgaat ttgttagaaa atctcatcat gttgtctcct 2361001 atttcaatat attcgtggtt tttattctca gcctacatct tggtgttcca aaatcgtagc 2361061 acaatgtagt acttagaatt cttttgtata ctgtgaaact gtccctgcat gcgggacatc 2361121 attcgcgcaa tgcttctttc accgagtccg ttgctttccg gtgttatatc tgcaagttta 2361181 atcgtattgc taacatggat ctcaaatatc tcttgatccg atacaaacgt gatactgatt 2361241 ttttcttccg gatctgcgta tttcaataag tttgacatca cattatcaaa tacacgacca 2361301 agctcctcca aattcacgtt aatataggtt tccggcagct cgcctgaaat atggacccga 2361361 aaatgctcct gatgaaggat agcaatctga tctgatatta gatcgtagat cacttctttc 2361421 actgcaacgg tctccagatc ggcctcatat tccttgttca gcaggaaata cgcaaacaga 2361481 ttgtcagaca agctttttaa ttgcagtgct ttaccataag cattggctac ataccgatct 2361541 ttgctggcac ccgcttcgcc tccctctttt ttggcaaact ccagattcat gatcagcgac 2361601 gtcagcggtg tgcgcatatc gtgcgacatt tcggtaacca ggctgcggct ctcagcttgc 2361661 aattcctcga tagctttaag tttatccagg aaagctttcc gcagatcctc aatgctcttt 2361721 gcaatcatcg ctaattcatc atgccctttt atcgtcatct cgtagtccag ttcgccccct 2361781 tcaagaatat gaatctcttg atgaatcgtt ttaaggtagc gaagactttg gcgaattccg 2361841 aagagaacaa tgattaaaaa gatgagggtt gccccgagca aatccaatgc aaaggccaga 2361901 tcataatatc gggaagagta gaaaccgtcg ataatgactc gtccttcacc atcgctaaac 2361961 ttgacaggat gtgaatgatt ttgagcgtac tgagtcagct tttcctttcc ataatccgat 2362021 tcggaataaa tagaatcata ttgcagctcc tgatccttga atatggtgag gttaatgtaa 2362081 ttttcttttt tgacccactc gccaaacgct tttctatctg atgtagacaa ctcattttct 2362141 gaaacgtact tgctgaattt ttgaatgtat cttgctgact cctcgtgata atactcttcc 2362201 gaactcagat atccctcgat cagatcatct gtgatctttt gcaacgtcag aaagatcaca 2362261 ccactcacaa tcgcagcaac cattatcagc aaagccagtt ttttggttag cgtaaattta 2362321 agatgcgcca aatcgatatc ctcttcccca ttcagttttt atataaaccg gacgtgccgg 2362381 atcatcctca attttggagc gcagcttccg tatatgcacc atcaccgtat tgttggaaca 2362441 gtaaaagtaa ggctgtcccc acacactctc atatatattt tgggcagaaa atattttgtt 2362501 gcgtttgttc atcagaagtt tcaggatacg atactccaga tctgacaact tgatttgctt 2362561 ctcctctttc cacacctcat taaattcttc gctcactctt agtttgcccc cgataagaaa 2362621 tgtttcttcc tgttccttct tttcctgata gatagtatat ctgcgtaatt gagcaatcac 2362681 tctagcgtga agttcctctt ccgagaatgg tttagtcata taatcatcgc cgccggcgag 2362741 taatccctca gttttatcga gtgtactcga tctggccgtc agaaacagaa tcgggacgtt 2362801 agaggatttc ctgatgtgct gacatgtttc aattcccgaa atgcctggca tcataatatc 2362861 caaaataacc aaatcaagcg agtcattcac aagttgcaat gctcgctttc catccttggc 2362921 tcttagcacc tcgtaacctg cacgtgtaag ggattcctcc aaaagatcac caatatcctc 2362981 atcatcctct acgactaata ttcgataggc catgtctctc tcacctcatg attcttgttg 2363041 ttatttctcg tgtgtcctta ctatatatcg ttcatagtaa taagtacgtt ataagatact 2363101 acgtaaatct taacaattta tgaaagctga tgctcgccac aaatttgtca cattttctaa 2363161 aaaaaatgat gactcttcat aaattgttaa gattcggtct ttatatttat ccattgtaag 2363221 gctcaagttt ttcagatccg cactacacat tgccgtgata aatgggaaag gagtattgat 2363281 atgattgtac aaaaagaagg acgcgggcaa ccggtgagtc tgcgggaacg ggttcatttt 2363341 ctggacatcg tacgaggatt tgccttgctt ggcattatta ttgtcaatta ttttctgatc 2363401 gtagattcag taaagggatt cgaaatggcc tccgatgacg tactgcataa gctggtttcc 2363461 tggtttgccg aagggaaatt cgttacgtta ttctccttcc tgttcggagt cgggtttatg 2363521 atctttatgg atcgagccgc gcagaaggta gagagtccca acaagctgtt tgcccgcagg 2363581 ttatctatcc tgttgggatt tggcattttg cacatcacat ttgtttgggt cggtgacata 2363641 ttggcctttt acgccgtaag tggcttcctg ttactcgcct tctataaacg cacggccaaa 2363701 acggtgctta gatggattat cgcacttatc gtgtttcaat tcctgactcc tgttttcaca 2363761 atgttgtaca atgtcatcaa tactgcaggg tcaaaaaacc cgaatttttc agagtttact 2363821 ttgtttagcc acagcagcct tacctacatg gaatccatca gcactcggtg gacagatatg 2363881 gtcacgatgg ctgccggctc tttctctatg atctattcca tgtttctcat gtttctgctg 2363941 ggcgtgtact ttgttaagat ggaatttttc aaagacatgg aagcgaaaaa gcctatatgg 2364001 aagcgtatct ggatcattag cacaatcgct tttctaataa cacaaagcag tatattacta 2364061 gacatgttta atctttctga gaatatgctg tggaaggaca tttcctctgt cttgggtcaa 2364121 aatggcggct taaccggaag tatgttttat atgagcactt ttgcaatgct gtttctatac 2364181 cttcctcagc tgcgaggccc tatgatgata ttcaccaaag tcggacggat gtcattgacc 2364241 tgttatctgc ttcactctat cattggaaca gttctgttcc tcaggtacgg attcgggctt 2364301 gcggatcata ttcaatccgc cggcacgttc atgttcagtc tggccgtgta cttcgttctt 2364361 atgagcttta gtacattgtg gttgaaacgg tttaggtacg gtccgatgga attagtatgg 2364421 cgcaagctga cgtacggcaa agtaaacggg agtcccaaag caactccgct gcattcggaa 2364481 aaatctattc agaaataacc cccttgcaca gattgcatga cttcaaatta gtgttgttga 2364541 atgaagcggg cattaaacgg acagatttga tatatggact agttattttt atatcattta 2364601 ggcttctttg ggctaataaa tccaccagag tttactcaat gtgcattgct catgatcgaa 2364661 tctaaattga atcttttacg catgttcata gtcaaaggcg cctcattcga ctatttttgt 2364721 aacttttcgc aggaaaaatt cgagaatgat gacaaatccc gcatacgaca cttaatacgg 2364781 tagtgaacaa tagtaaatta gggttacatg cagcttgttt tccaatgaaa caaagaaaaa 2364841 gaatcataca aaaagacagg agaaagcttt tgaagtattt taacgccaaa tttaccgcgg 2364901 aagaaagagc gatggaatca cttttttgtg aaaaggcctc gcagagcagc tcgaatgttt 2364961 tactgaacga ctgaactcta tattttagca actgagggag tgaacaatca tgaaaactaa 2365021 aaatgaacca aaagttattc tggaactagc aaaggaatct gatctgccag aattccaaaa 2365081 aaaattacaa gaagcctttg cgatcgccgt gattgaaacg ttcggtgatt gcgaagatgg 2365141 gccgattcca tcggacaatg atgttcagga gtctttcaat gctcccggag cagtggtata 2365201 tcatattctt caggatggta agaatgtcgg tggtgcagta gtacgtatca acagccaaac 2365261 aaatcataat tcgctagatt tattctatgt atctccagaa tatcacagcc aagggattgg 2365321 tctttctgct tggaaagcca ttgaagcaca gtatccggat actgtgcttt gggaaaccgt 2365381 gacaccttat ttcgaaaagc gaaatatcaa cttctatgtg aataagtgtg gatttcatat 2365441 cgtagagttc tacaatgaac atcactctaa tccgcatatg catcgcaatg gacgtgaaga 2365501 tgacaagccc ctactgaatg atgatgactt tttcagattt gtaaagatta tgaaaaaaaa 2365561 ggactaaaca attgaacacg gcgagatgcc gcagagagtt gctggtaact tttttatatt 2365621 tcattatcag aggaaggtaa taatgatgtt taaaaggtgt tttgatccct gtctcataaa 2365681 caggggtcaa aacacctttg aatcatcggt ttcttttctg acatatacca cgcccactag 2365741 tccctcaaca tagtaaaaac atatcatgag ttacaaaagc ttttattcaa agcatatgtt 2365801 tattttattt atacttattt tcatcatttt tcagaattct ggacacaaat cgggtaccta 2365861 ttagaggcca aggaactcta catttcatta agaaatacgt actcattgcc ctgctttaat 2365921 taattttaag ccctcgcact atgccccccc ctgaattaag tatttgatgt aactttgaaa 2365981 ttaagtttat gaaaatctgt cacaaaccct tatttcataa cacatcattt gtttcagctt 2366041 ccctcgcgaa taccggatta atgctcggct ttaagatagt caaccaatct ctccgcactg 2366101 ttcttaacat cttcttttga aagatgaagt gtcccatatt gtgtaaacgc aggaagaaaa 2366161 cgcattccta tatagttagc agtgacttga aacggtctga taagctcgct gatcgtgata 2366221 ttatattctc cgcctgcttg ataatcagat tcctgtgcgc ctaaggagat agctaagagt 2366281 agttcttttc catgcaattt agttcctcca gttccataag cccagccatg tgttaacaca 2366341 tcatcttccc attgtttgag taacgcggga ctgctgtacc aatacattgg gaactgaaaa 2366401 acgatacgct catgatctaa caggagctgc tgctcttttt ctacatcaat gataaaatta 2366461 gggtattcac cgtacaggtc atgaaccgta atgtctttct cttgctttaa acgattcatc 2366521 caggttttgt tgacaacaga cgtttccaaa ttaggatgta taacgataac taatgttttc 2366581 attagactga ttatcctttc tttgccaatt agttattatt ttttacgata atgaattgat 2366641 tctaatttta aaatagcaac tttatttaca cctattttat cctttttcat gaattcaggg 2366701 caactaattg ggcaccaaaa tcaatgatga cttaagacat tgttttgtag aaatccgata 2366761 tacagaataa tccattattt agaaaatttc taccttttcc ctcaatcctt accaatttaa 2366821 actcattaag gagatacttt atcaccaact ttaaataata atggaataag tgctaataaa 2366881 ataattccta caaccaacgt agatattatt aactccttcc atacaatcaa attctttaaa 2366941 aacatttgat aaataactaa tgagtttact ggaatgttaa gcaataagcc cgtaagaagt 2367001 ccaggtgcat actttttcat tacaacagtt gcgataagat gtggaaaaat agcgttgata 2367061 accatagaac ctagaaagcc aatgaaaatc cattttgcaa tatctgattc tggcatatat 2367121 aaaaaaccaa atgcagataa ataagccaac atagttataa caatgacagc aaaatgaaat 2367181 tcatttgaag ttactggctt ttgaaacttt gaagattgtt gtgaccactc aggtaaccaa 2367241 atagcttcct caatattatg aagtgtaata gcaaaacaaa aaaatgctac gaaataaacc 2367301 acctatcatt tcctcctcgg tgccacaacc aatatggttt ggcaacatta tattacattt 2367361 gaggctgatt ggatatggtg ttaaaagaga gaagaatctg ccttagtagt tgcttcttaa 2367421 ttatatgtgc aataacgtgt tgttacgtgg catgtcatat tcaaatataa taactctaaa 2367481 gcaaacaaag atacctatat agtttggcat cctctttttt agttcgagtc cctctattta 2367541 ttttgggcac aaaatagaca taatttatat tgactcatta tacccatcac ataccatacc 2367601 ccttaaacca atcaggatta aaatgtttta aaaaaggtga tcaaagatta agttatggtc 2367661 tcttttattt tatgtatgct gtcttaatgc aaaacaacac tggacaccac taagtcaaat 2367721 gcatttcatg gtactatagt caagacttgt ccaagtcacc attatcaaaa tgaatttcat 2367781 caaacacttg aaacatttat tgaacgcggc caagtgtcat aacattaata agaaaccaac 2367841 gagtgatgaa tcttttaatc tttcatttta cccgctggct catatcaaag gagctctaac 2367901 caaattttaa tagctgtcgc acctattaat tgcgctaaaa cccattgcag gaattttgta 2367961 tttacttttt gcccaactga tgcgccaata ggagaagcta ttaaactagt aatcataaga 2368021 accagagctg gtacaaaaag aacctggccc gtgattactt ttccaactgt tgcgccaatg 2368081 gatgaaagaa atgtaatcgc aagagatgaa gcgactgtga ctctaacagg aatatttaaa 2368141 atcgataaca taatggggac taggataaag gcgccgccag ctcctaaaat acctgatacg 2368201 ccaccaatga taaacgctaa ggaagaagcc aaccatttat taaatatcac ttccttatct 2368261 tcgctatgtt cttgtccttt ctgtcctttt ttaggtataa acattaaaat aactgctata 2368321 atagccagaa ttccgtatat aaagttaatt cctttttcag atatataatg agaaaagtaa 2368381 ctccccaata cactccctaa aaggatgctg cttcccatgt aaataattaa tgttttattt 2368441 ataagaccac tcttacgata agcccaaaca ccgccgagtg tcgcaaaaaa aacttgaata 2368501 gcccctatcc ctgaaacttc atgggcagtt aatgacatca ctcccactaa agaaggaatg 2368561 tacaatagca ttggataatt aataactgct ccgccaatac caatcattcc ggaaataaag 2368621 gcaccaataa accctataat gaaaagagtt gtgataaagg caatatccat tttatttgcc 2368681 tcctttcata ggaaaagggt atctttctat tcgataccct ttcacattca ttagcctttt 2368741 tgaatccaaa atttcaatat atcgccctcg tccgtttgct ctaaaaggtc atgtccgcct 2368801 gatttagacc aggctgtaag atcatttttg gctcccttat ctgttgcatg cacttctaat 2368861 atttgacctg attccagttc attcatcgct ttttttgttc tgacaattgg cattgggcat 2368921 gccaagcctt ttgcgtctaa tactttatct gatttcatgt tcttctctcc tctttttagc 2368981 agaaacttgt gttaccgtat tgcacagcgg tttgggccaa tctccatttc acgctgtttt 2369041 tcttcatctg ggctgatttt ccccatgttt gtttctcgaa tctcttggta tgcatttggt 2369101 tgcggaggca aatgatctgt tactaggtgt ctaaattctg tttcatccgc aatgttcaaa 2369161 ccatggttct cgctaaataa tgtacttagt tgtttaccaa cacttccatt ctcatttagc 2369221 tcgtcaatga tcataaagtg tgccggtaat acaattaaat cctttgataa cgctttgtaa 2369281 cggctataaa gcgtttttct taaatctcct acccaatctt ctgccatacc ggctaagtct 2369341 ggtctgccga ttgaatcaat aaacaagata tcacctgaaa gaagatactg gtcatcgaca 2369401 atgaaagaag tggagccaat cgtgtgcccc ggagaataaa tcggttgaat tttaatcgtt 2369461 gtatttccaa taataatgtc atttccttct tccaacggct gataatcgaa ttccacttct 2369521 tcagcatctt taggcggtaa ccagtaggtt gcttttgttt tttcagcaat gactctgccg 2369581 cctgaaatat ggtccgcgtg aagatgtgta tcaaatacgt gagtaatcgt tgcacccttc 2369641 cccttcgcaa aatctataaa gaaattcacc atacgtgtcg catcaataat tgctgcttca 2369701 ccattggaaa tgaccatgta tgacaagcag cctttaccga ttcgaacaaa ctgatacatc 2369761 tcaccgccat cttttaaatc cccgactttt accggctcta aatgttcgct ccatgctttc 2369821 attccaccct taaggtagga tacagaatga cctgcttcag aaagcatttc ggataccatg 2369881 acggatgaac cttcttttgc gcaaacgacc agcacttctt tatcagaagg aattttctcc 2369941 aagatatctt ctacgccatc taaaagatca aaataaggaa cattcaaatg gtcaaagtca 2370001 tgcccttcta tcttccaatc actaaaatca ttttcattac gcacatccaa aataaataaa 2370061 ggttctttgt taaagatttt tttgtcactt cttttggggt cattgccttt acggtcatgt 2370121 ttcaatacct cctatatcaa atcttttagc gggactaaaa cgttaaggat acatcagcat 2370181 ctttcgtaaa accaaaaaag gtaacagccc cgcctacttc gattccttcc ataaaatcat 2370241 cttttgttaa acccataacg tccatcgtta tttgacaacc aaatcatgca actcccattt 2370301 caatcagtta agaatagaag gcacatttgc gttcctacaa ccttctgcga catgctcttt 2370361 tccttgtcgc aatattacag actttataag catcaaacag accgctattt gccgcaataa 2370421 tcgctactct tgtactcatc tgttcatcat gctttttatt tattcggttt tacctgtcca 2370481 atcccgcata cccgggacaa cattaataac ctttttaaaa ccttgttttt tcatggtgcg 2370541 ggccgccatt tcactccttc ttcccgaatg gcagataata taaatttcat cattttcgtt 2370601 taattcgtta gcgcgctttt ccacttcacc aagagggata tgcacaactc ctgggatatg 2370661 agctttttca tattcctcta tctctcgaac atctaaaatg ttaagagact cgtcactatc 2370721 tactttctgt ttgaaagctt ctaatgaaat ctcaggaatt gaagatgcat tttctgatga 2370781 atgctctcct ccttttcgaa gaaaatgacg aagtatttct ccctctgctt cagtacccag 2370841 atattcatgg cctgtacttt ttgcccatgc ttccagatct gctgtagaac ctttatctgt 2370901 cgcatgaatt tccaatactt caccagcttt taaatccttc attctcttct tcgtttttac 2370961 gataggcatt ggacacgcca aacctttagc gtctagtaca atagttgctt tcatcatttt 2371021 ttcctccttt tcttatatag gggtgggggt atacaaatat acaaaaagtt tctcactgta 2371081 agttaacacc atgtattcat accccctttt atatttgtga tgtttttaaa tccttgtttc 2371141 ttcaatattt ttacttgcct ttaaacttct cattccgctt agcaatgagt aaatgagtaa 2371201 cattagataa ataagttgac actgccttcc tcagcatctg ccaaataagc tgctacacca 2371261 gcatagtcaa tatcatctaa tagttctttt tcctgtaaac caagaagatc cattgtcatc 2371321 gtacaagcta cgagctttac cccctgttct tgagccatct caatcaactg aggtaaagta 2371381 agtacattat gctttttcat cacattttta atcattttag ggcccatacc tgcaaagttc 2371441 attttagata aacccatctt atcagcacca cgaggcatca tctttccaaa cattttttca 2371501 agaaatcctt ttttcactgg aatcagctct tctttacgta aagcgttaaa tccccaaaaa 2371561 gtatggaaga tcgtcacttc atgatcgtag gcagctgcac catttgcaat aatataggct 2371621 gccattgctt tatcataatc cccgctaaat aaaacaattg ttgtgcgttt tgtttgttct 2371681 gtcatgttta ttctcctaac taattacccc tgcgggtata ttaaagtcaa aaaatttttt 2371741 cgaaagatct gcttttattc aactctttaa ataccatagg gggtataata taacgcatat 2371801 aaaaattcgt caaccttagg ttgatgaatt tttatcggct ctttaccaat aagtcgactg 2371861 cttcttttac taaattttgt gtgtcttcgc ctttttctaa actttcacga acacaatgtt 2371921 caaggtttgt gctcacaatt aaacccatcg ctcgatcgat cgcattacgg gaagctgcta 2371981 attgggtcac aacctctcta caatcttttc cttgttccat catagtcaat acacctttaa 2372041 tttgtccttc aatccgtcgt aagcggtttt taatcttttg atcatactcc atatatcaat 2372101 gaaatccttt ctttcattta tttttacatt tacatgttgc cagttcataa ctgtttacat 2372161 ggataccttt gcgctttaga aaacgcactc ctaaatttaa ttccacccgg tcacgagcta 2372221 ttatgtgtat tttatcacgt ggaatctcta aataaaaacg ttttagatac gcatatggga 2372281 tgtttaaaat aatattatcc gaaaaattgg ctacatcgtt ataatgacga atatctaata 2372341 ttgtgatgtc catagcctct aatttatctt tatggataca agagattccg gttataggat 2372401 aataacgtct atacgttgca atgataatca caaaaataag caggaatgca ataactaaat 2372461 aattgatact atttacacca ccttattaac tctttgttta ttcacaaaac aataatatac 2372521 ccccataggt atatagtcaa gtgtgaaagt tactttcttt gagctgatag attcatttcg 2372581 atatccgcgg attgaaaaaa tacttacatt cgataatgcc aattctgcta aaaggaactc 2372641 gaataaagca ataagccgat ttaattttaa atcggcttta tttatcaatt acttaaaatt 2372701 agcacaagac acgctgcttg gatattaaat ggggtttcat tagcatggta ctggttcccc 2372761 atgtttcatg ctggatgtga ctttaattat tctagaattc tccagaatat ctgtgctaat 2372821 cttccgcagc cactgcatct gctttggttt catgaactgt accaaatgga tggttaggag 2372881 gagcataaat ggagtaaagt tttaatggcg tatttcctgt attaattacg ttgtgccaag 2372941 tgccggcagg gacaacaatg gcagaatcat catagacatt tctttgaaag ttcaaatgat 2373001 ctttgctctt tcccattttg acgatcccac gcccctgctc aatccgtaag aactggtcaa 2373061 cgttaggatg gatttccaaa ccaatgtctt ctccaatacc aagactcatc aaagtaactt 2373121 gaaaatgctt tcctgtccat aaagcagtac ggaacgtatt gttttgtttt gtggctctat 2373181 tgatatttac aacaaatggt tttggtccat aatccttcaa aagaaggttt ctatcttcat 2373241 atgaagagcg caaatcggca cctctgtgta ctttctccat ctcatttgga atagtccaat 2373301 aaacagatct tccatcatta tacatcggca cagtcacata ataataacat tgaggcgaaa 2373361 aagggttata gtacattttt tgatccccgc aattataaat ttttgtgata gtatcctatg 2373421 catttattaa gggagtgtgc taaatcaaga aaactcatat taaacacaaa aatgaatgtt 2373481 cgatcaccgt ttgattcatg gatgaataat ttatcaccga ccttgtaatc gttttctaga 2373541 tgttgaattt cactagcctt tgttaacaag acatcgaatg acacctttat atgatggatt 2373601 atcaaaggtc gacgatccta aatggctttt gaacatttac atagcacaac aacagagtat 2373661 acggaattct gttgtttgtc ccccctatcc cagctctttt agatttatct ctttggatgc 2373721 gccttgatgg ccagtttttc agcagcatag aatttatccc ctcctgaatc gttatagcat 2373781 atttcaacgc cgatagactt gcggttccca gtgccgtttg taccgtctcc tgtatgtggg 2373841 ctcgctttta gtaaaccagt ttatattctt tttgggcaca caacagaaac aattttccat 2373901 atgaaaatct cgtaatttta cacctcttta acttgaagga ggatttttgc atatgtattt 2373961 tcatacccgt caactaccat ctcatccagc atatattcct catatgcatt ttcccctatt 2374021 tgcattccat ttctttcaat gaactcaatg attctccggt acgcctcttc agtatttccg 2374081 cctatttcat atccaactgc atacaggcct tttggccgta catgataatt tatgttctct 2374141 gccccatctt ttacttttat ataaaagtaa ctgtaattgt agaagtcttt ttctaagatt 2374201 tgttcccgtg caaagattcc gcctatcgga tatccttcat ctaattcata ttgctgaact 2374261 tcatgaatga gttctgaaat ggctgccaca tattttcgtt ctggtaagtt taatgttttt 2374321 cggcttaaca tgaatgtttc ttcatttaaa tattcaaaag aaattgagga aaaatcagtc 2374381 tcaagtgctt gttctgtaag cgtcactttt gtttgtaaga tcgtttgcaa ctgcttaagc 2374441 tcatttattt ttttatcaat ctcaatagac ttttctttta gaacatgcag gatcttgtct 2374501 ggtgtttttc cttttattag acactttatt tcttttaatg gaaccccaag ctctttaaat 2374561 agactgatga cttgaaaagt ctcaaattga tgataggaat aatatctata cccattttct 2374621 ttttttattt ccggcgagaa aagaccaatc tcatcataat gaaataaagt ttgttttttt 2374681 acacggcaga gcttcgaaaa ctcccctgtt gtgaaatact tcttaacatc ttcgctcata 2374741 aaaacctcct tgactatacg gtaaccatat accttatgat ttgattgtac ttgaaaaaag 2374801 cttcaagcga aaaggatagg taaaaagggt tcaattgagt aaaaggggaa ttcagatgaa 2374861 aaaatcaata aatgagcaaa aaacgatatt cattatacta ttaagcaaca tcttcgtagc 2374921 atttcttggt atcggtttaa tcattccagt tatgccttct tttatgaaaa tcatgcattt 2374981 atccggcagc acaatgggtt atcttgttgc ggcttttgcc atttctcagt taattacttc 2375041 accttttgca ggtaggtggg ttgaccgttt cgggagaaaa aaaatgatta ttctcgggtt 2375101 gcttatattc agtttatctg agttgatttt cggattaggg acccatgttt caatatttta 2375161 tttctcgagg atattgggtg gtgtaagtgc ggcttttatc atgcccgcgg taacagcata 2375221 tgtagctgat attacaaccc taaaggaaag gtcaaaggct atggggtatg tttctgctgc 2375281 aattagcacc ggctttatta ttggacctgg tgcgggagga tttattgccg gctttggtat 2375341 ccgcatgccg tttttcttcg cctccgccat cgcgttaata gcagctgtca cttccgtttt 2375401 tatactaaaa gagtcattgt cgatagaaga acgccatcaa ctctcatctc atacaaagga 2375461 atcaaatttc attaaagact tgaagagatc cattcatcct gtctatttca ttgcatttat 2375521 tatcgtcttt gtaatggctt ttggtttatc agcttatgaa acggtattca gcttgttttc 2375581 tgatcataaa tttggcttca caccaaaaga tattgcagcc attattacga ttagttccat 2375641 tgttgcggta gttattcaag ttttactatt cgggaaattg gtcaacaaac ttggagagaa 2375701 aagaatgatt cagctgtgct taataaccgg tgcgatcttg gctttcgtgt ctactgttat 2375761 gtcaggattt ttaactgttt tgcttgtaac ttgttttatt tttctggcgt tcgatttgct 2375821 acgtccggcc ttaaccgctc atttatccaa tatggccggt aaccagcagg gtttcgtagc 2375881 aggcatgaac tccacataca ccagcctggg aaatatattt ggacctgctc taggcggtat 2375941 actatttgat cttaacattc attatccttt cctttttgca ggtttcgtta tgattgtcgg 2376001 ccttggtctt acaatggttt ggaaagaaaa aaagaatgat gctgcagctt tgaattaatt 2376061 cattttctat aaagttaagt catttggatg cagggaatgc ccctggttag gcacaataag 2376121 aaaaggtact taatttgata ggctacatgt tgcttgacgt gaatatagta taagctgagt 2376181 tttagcaata tcaggatacc gggataagaa aaaaggagaa tgtagtatga gtataaacat 2376241 aaaagcagta actgatgata atcgtgctgc aattcttgat ctacatgtca gccagaatca 2376301 attatcatat attgaatcta caaaagtatg tttagaagat gcaaaagaat gtcactatta 2376361 taaacctgtc gggctttact atgaaggaga tctagtcggt tttgcaatgt atggattgtt 2376421 tcccgagtat gatgaagata ataaaaacgg acgagtctgg cttgaccgat tttttattga 2376481 cgaacgctat cagggaaaag gattagggaa gaaaatgctt aaagccctca ttcagcacct 2376541 tgctgagtta tataaatgca agagaattta tttaagtata tttgaaaata atattcatgc 2376601 tatacgcctt tatcaaaggt ttggttttca atttaatggt gaactcgact ttaatggtga 2376661 gaaggtaatg gtaaaagagc tatagatatc caagcctcct tgtttgctga gaaacgtttg 2376721 aacttcgata atgattacct acttaaactg caagatcatt gtttaaaaaa gcctggatga 2376781 aaatttcatc tcaggcttta agcatcttat tagtcaaaat ctcatgtgtt ttatccagat 2376841 gttattcttt tttccggaca atttctaaat aattaatatg ccggccaact gtttcgtgca 2376901 ctttaaaaat atacccatcg gcttctataa cggacccaac tgcagcgtct atttgttgag 2376961 tcataaacca gccgcctatt gtatccactt cgtcacttgc taacgtcgtt cccaataaat 2377021 catttacatc ttcaatgagc actttcgaat ctaagatata gtgattatca tttacttttc 2377081 taatattagg cacttcatct ttatcaaatt catctctgat ttccccgaca atttcttcaa 2377141 gaatatcttc agcagtgact aaacctgaag tgccgccata ttcatccaca agaatagcga 2377201 tatgtgttcg ctctttttgc atttttacca atacatcatg aattggaacg gattcaataa 2377261 catggataac agggttgata tgattttcta acttgaaatc ctcttttatc ttctggtctg 2377321 tgtcaatata agctgacaaa aattctttag cattgataaa accaatgatt gaatctttat 2377381 ctccatttag gactgggtac cttgtatagc tctctgtctt aatgatctta acaatagttt 2377441 cataagaatc ctcactagaa atcgctacga tctctcttct cggaatcata atttctttgg 2377501 cgattctttc atcaaattca aaaatattat ttacatattt caactcattt tgattgattt 2377561 caccgctctt atagctttca gacagtaaga tgcgcagttc ttcttcagaa tgagcaagtt 2377621 catgttctga tgcaggtttc aaaccgaaga gtcctactat aaaccgggct gaaccattta 2377681 aaaaccatat aaaagggaac aggatgcggt aaaaccaaat aattggcttt gcagtcaaaa 2377741 gagtgatggt ttccgctttt tggatagcga gtgttttagg agcaagctct ccaactacaa 2377801 cgtgcaaaaa agtcgccatc acaaaagcaa tcactaagat caatacatgt gagactgttt 2377861 cacttacatg aaaatgagca aataaggggt gcaaaatcac ttcaaaagtc gattctccga 2377921 cccagccaat tcccaacgct gtaaccgtga tccctaattg acaagctgac aaatattcgt 2377981 ccaaatgagt aatgaccttt ttggctgata tggcaccttt ttttccctct aatatgagtt 2378041 ggtcaatttt tgatgacctg atctttacta tcgcaaattc agtcgcaaca aaaaatgctg 2378101 ttaagacaat taaaagagta aagattataa ggttaatggt tgtcaatgat ttgccttacc 2378161 tagtaaggcg tacacctccg atgtaaatat ttattgaata aacaaaaaac agtatatata 2378221 acattataag ttcaaaagaa cctaaaatca actctgaatg atgtaaataa tcatcttttt 2378281 ccgtatggag agtggttccc atagtcttca actaacgatt agtggcgttt taaggcttaa 2378341 aaaagaaagc aaaataaaaa cacacctgaa ttttctggtg tgtttcaata atacccaacc 2378401 gtcttgattt atttaatgtc tttataaaga ttttctttta aaatttgaat caattcggcc 2378461 tgttgcttta tatttttgcg gccatttcta ttaattgcag caagttcaca gacaattcca 2378521 gctgaaatga aaaacaataa accttcaaac attttaaatc ccccactgtc taagtgatag 2378581 tcaaatttgt tttttctttt tgcaatacct gcttataatc ttccttacgc tgatatatgt 2378641 tatttaaaat gagtccaata atgacaaaca gtgttcctac tatatcaaaa gcagttatgt 2378701 tatatccttt gatcaccatg attaacaatg tagtaatggg gacaaagtta ataaataaaa 2378761 tcccattaat ggatgatagg attttaatgc catagttcca actaaggagg gctatgatac 2378821 ctggtaaagt aatcataaat aaaaaatcat acttaattgc tgcaatcact ttaatactcg 2378881 gtaccgacac gtaaccttgc gcggtaagta tagctgtcat gattcctgtt atagctgtgc 2378941 cgaataaaca tgtcaaagtt gaataacgaa gtgtggacca ctctcggaat atctgtcccc 2379001 ccattgtgta gacaacccac cctaaaacac caatgaatat aaagagtatc gagaatagat 2379061 gatcccctaa tgaaaaaaag aaacttatat tacctttggt tatgaccatc gaagccccca 2379121 aaaaggcaat caatatactg atcattgtgt attttttagg tttcacatgt ttatatcccc 2379181 atagaataac aattgaaagc atcggcatga gtgcctcggc aatggatgct gtcataattc 2379241 cagacttccc catcaacctt tgacctaaaa aaataagaac attgtatata gtaaacgcca 2379301 tcaccccaaa taaaatgatc cattttgctt taccctctaa atgaaatgat ttctttcctt 2379361 ctctcaccaa taataaaatc actaacataa tcgttaccac accgtagcga ataaatgaaa 2379421 aataaaacgg atcaacaaat tctaatgcat gatctgcaac tggaaacatc gcgccccaag 2379481 acatacttgc tactaaacat gtaagggcac caatgaataa ttgacctttt ttcattgaat 2379541 tcccctcctt ttctttaaaa ttacaatgag aattataaaa agaagtaagc atcaagtaaa 2379601 atgaacaaaa gtgatgaaaa acatcattga taatgatact ttaatgaagg ggggatcttc 2379661 atggaactgc gagacttaca aattttcaaa tgcgtagccc atcacaagag tattaccggt 2379721 gctgcaaaag agttaaatta tgtacaatct aatgtaactg cgcggattaa gcaattagag 2379781 aatgagctca aaacacctct tttcaatcgc cataaaaaag gggtttcact aagcccagag 2379841 ggccgaaaaa tgattgaata cgttaacaaa attttgaaag atgttgaaga actggagcaa 2379901 gtctttctag atactgaaat accgtctgga atattaaaaa tcggtacagt ggaaacagtg 2379961 aggatactgc cgaccatcat agcttcctat tataaaaagt atcctaatgt ggatttatca 2380021 ttgcaggctg gtctaacaga ggaacttatt aaaaaggtca tgaatcacga attagacgga 2380081 gcttttattt caggcccctt gaaacattct attctggaac agtatgatgt ttatactgaa 2380141 aaacttactc ttgtaaccag taacaaaacg tttaatatag aggatttttc aacgactccg 2380201 attcttgttt ttaaccaggg gtgcgggtat cggtctaggc ttgaacaatg gctcaaagat 2380261 gaaggtgtgc tcccaaacag aatgatggaa tttaacatcc tagagacaat cttaaatagt 2380321 gttgcacttg gactcggtat aacagtggta ccggaatctg ctgttatgca tctagctgta 2380381 caaggtaagg tttattgcca cccattgcct gagaaagaca gctgtatctc aacaattttt 2380441 atacgccata aagatgcgta cctgacaaat tcaatgcgca gcctcctaaa gaccattgtt 2380501 gaacataaaa atatgagtat ggcttaaagt gatttttctc tttctatatt ctaacttctt 2380561 aaataaaaga gaaggctcat ctccacttcg ctacccttat tcacgcaaaa aatagagcag 2380621 taaacatgtg agttactgct ctgcttcgtt tattcaccgt tcatttgttt tacaatgtat 2380681 tcagcatcat ttcctacgcc ttgaagcaac gctgaacctc gcttatgctg ccaaggcaaa 2380741 cctataaagt acaatccttc tacaggtgaa acacctctat gatgtatgat tcgaccttct 2380801 tgatccaaaa caccttttat atttatccaa cataagggat tcctgaaacc agtagcccaa 2380861 ataatattgt ttacttctaa tgtagatgaa tctttaaaaa tgatttcatt ttgctttgcg 2380921 gcaatgactc ttttttttaa gatgatctcc ttctgtttta ttgcatgttt taattcatgc 2380981 ccaaatactg gatcaccttt cttttgaatg aatttgccta ctattgatgt atgacttgca 2381041 tgtaaaactc ctagtttatc aaaccaccaa aagatgcttc tttttccgat cattaaaggg 2381101 aaataaacaa gtttattact acaagctaaa tatgtaactc tttctttgga taattcaaca 2381161 gctatttgag caccactatt cccaccacca actactagta catttccata tgccaattgt 2381221 tttgaattct tatattgtga tgagtgtagt tgattaatat tatcggataa atcctttgat 2381281 attgatggaa tattaggggt atgaaaaggc cctgtagcaa tgacaagatt cttcgtttga 2381341 tattcttccc gatttgtttt tattaagaaa taattcttta tttttaggac acttattact 2381401 tctgtccgta attggattgg aatttcaaat tttttaacat acttctttag ataagcaaca 2381461 atttcatttt ttgaaggaaa tccatgtttt tctccttcaa gatgcattcc aggcaaagag 2381521 ctatacattc gagaagtaaa taaaactaat gagtcatacc gatctttcca gctctccccc 2381581 acctcatgac ttttatccaa aatgataaac ttttgatcgg actgcttaag ataatatcct 2381641 attgagatcc ctgcttgacc agccccgatt actatagtgt cgtacacatt atcaccccgc 2381701 caatttcaaa ttgtcagtag acagaatctg caaaatccta gttgatctcc tcactataaa 2381761 gttagataaa aaatttaatg gtgatggtgg tcacgctgct tctccatttt gggctgacaa 2381821 aggatcgcat tgtcgtggtt atgcgcttcg gtttccattt gaatggttac gtgcgtaatg 2381881 cctttatgct caagttcatg ttcaattttg cgtaaaatat tttcactttc tgaaatggtc 2381941 agttgatcgt caacaactgc gtggcaagaa agagcattca atccgcttgt gatagaccat 2382001 atgtgtaaat catgaatgtt ttgaattccc tctgtccctt caattgtacg aatgatatca 2382061 gagacatcga tattttctgg agttccttcc attaagatgt gaatggaatc tttagtcaca 2382121 ttgtaaccgc ttcttagaac aagaatagcc acaatgatac tagccaatgg atctgcccag 2382181 ccccatccaa agaagatgat aagtatggca gctaaaatgg cacctacaga gccgagcata 2382241 tcgcttatta catgtaaata agctcctctt atattcagat tattctttgt atctccgcca 2382301 ctcatcataa tccaagcgac caatagattc acaactaacc cgatgatact aattgtaagc 2382361 atgccggttg ttgctacttt tggtggatta gagaagcgtt cgattgcttc ataaatgata 2382421 taaagagaaa taagaattaa ggcagcaccg tttatcacag ctgcaagaat ctcaaatcgt 2382481 ttatagccga atgtcttatt gtgatttgcc tttttttcag ctaatgtaaa agcaatcagg 2382541 gcaaccatta atgaaattga atcactcagc atatggcctg catcagataa aagcgccagg 2382601 ctatttgtta aaaatccacc tatagcttct ataatcatat aacctgtaat catgataaaa 2382661 gagatcaata aaaccttttt atttgctcct tcattatgat tgtgacccat aaaaaactcc 2382721 tccttaccta aagtttttaa tacatatgta tttattattt caaatctgtt atgaagcatt 2382781 ctaacatgat acaaataata tttatatatg agcatgtgtt catatataaa tatatctgct 2382841 ctttactgaa atgtcaaaat atttttatag aaatccacaa tacctcctta attattcttt 2382901 tataaacata aaaaagcgga gcaaacacat ggtttgctcc gctaccctag tttctctatc 2382961 cttttcttca atcaagcatt tgagggtagt attcaactac aatttacctg ttaaaaattg 2383021 ggcctcacca agtccaaaac tccagtcagc attatcattt tcaacaatag atacaattaa 2383081 atcagttgat gcgataccac actcagattc cagtctttca gctaacagcc tgtaaaattt 2383141 ttgtttcttc tcttccggtc gggatttact tgtaactgaa agaacaacaa gatttttagt 2383201 tcggttaaat cctaacccag tatcctcaat aatcatatga ttttctggat gttcatgaac 2383261 aatttgataa cggtcttgtt gaggcacatc aaaagcctct actacaacat tgtgagcgac 2383321 atctaaaagt tttttcaaac ttgattgatc tcgcccttct attaagtcaa aacgaagtaa 2383381 tggcataaaa tcccctcctt ctactacaac agtcttttta atttcattcg ttaatgtgtc 2383441 agctatttcc aagcagctgc tacatttaga aaataaagta atttcccaat aaccccttca 2383501 ttctggtgtt agtcaagcct atgttatgat gtgtatttcc ataggcaata tacagaatca 2383561 acttcgagta attaaccatt ttttgaaata gctttatcac ttactttaga aatcatttat 2383621 tcttctaagc tttagtttac atgaagctct gctatcatat ataattcaaa attaagatgg 2383681 aagacatctc aaaatcagat atcaactatg gaggactaga tgaatattca gttgttacag 2383741 gtttttctca ctactgctcg tgaaggcagt atttccaagg ctgctctgac tttaaattat 2383801 gcacaatcga atgtaacgaa taagatacaa caactagaaa acgatttaca gacaaaatta 2383861 ttctatcgtc atagtcgagg aatcacactt actcccccag ggcaaattct tgtttcttac 2383921 tcagagaaaa ttctacatac tattgaagaa gctagagcag ccatgggcga atcatccgcg 2383981 ccttctgggc cactgcgtat aggatcaatg gaaacaacag ctgcagtttg gcttcctcaa 2384041 ctccttgcac attataataa cctctatcca aatgttgatt tgaacctagt aaccggccct 2384101 acggaacaac aaatacaagc agttttacat tatgagttaa acggcgcttt tatttcaggg 2384161 cctattgaac accctgattt agttcaagaa aaggtattgg atgaagagat ggttcttgtt 2384221 acaagtgctt cacaccctgt gatttcttcc attcaggatg ttcaaacaca aacaatgctt 2384281 gtattccgta aaggatgctc atacagagca aagctcaatc atatcctgca agaagaaggt 2384341 ttattaccta taaaattaat ggaatttggc atacttgaag cgatcattgg ctgtgtaagc 2384401 gccggcttgg ggatttcact gctgcctcgt tcaatcattg cttcgcatga aaaagaaggc 2384461 cgcatccgca gccacactat ctctgacaaa tattcttttg tatcaactat gtttataagg 2384521 cggaaagaca ctttaattac ccctgcttta tctgcttttt taacgcatat gagggatcat 2384581 tttcagataa agaggccaga tcaatcgtaa ataaatggat ggaaggcatg cttcgcctca 2384641 aaatacccct gatcagttgt ctgatataaa aatataggcg catctcaatg tttgtataga 2384701 gcaaaaaagc aaacttcggt atgtagtttg ctttttcttc gtgattttgc actctgaatc 2384761 gtgaaaccta gtcgatatta ggatgtagat tttcctcatt caaagaattt tgaacgaagg 2384821 tcattgccct agacacttgg ttgcgtcttg aagttaaagg ctgactattt cctaaagcgt 2384881 caatcgctct cacaactatt aaatattcac ctacagattt cgggtgacaa cgggaagatt 2384941 gatattttcg gttggacagg ggcagaacat ccaattgtaa cagttgaagt atccactgat 2385001 ggaggagatc ctgcagatct gagtgatatt gctgttgatt gatcaacttg tttttgttcg 2385061 gaatatactc agtatatagc cgcatattcc tcctgcaata gctggaatga gccaccccag 2385121 ccctatgtta tacataggaa gaatctgagt gaaaatacga ttcacaactt caatttttat 2385181 tccagccgcc ttcaaaccgt caaataggct gatgatgaat gcgaataata aactgccttg 2385241 atacacttct gtcttccctt taaatacaga atgcaaaaac gttaaaaata ttaaggaaat 2385301 cgcgatagga tacatcgtca gtaagacagg cattgacacc ttaatgagct gggttaatcc 2385361 tatatttgcg acaagcgtac taaacactga taaaacgaca gcaatttttt tataagaaat 2385421 gttcggaaat aattcatgaa aaaatgaaga acacgctgtg atcagcccga cacttgtcgt 2385481 cagacacgcc actgtaatca ttaagcccaa taagattgaa ccataagatc caaaataata 2385541 ggatgaaacc ttagccaaaa cctctgctcc attttctaaa atccccagtt cttcaacgct 2385601 ggaagccccc atataggaaa gggctgtata cataactgct aagagtacag ctgcaatcgc 2385661 ggctgctttt gcacaaacaa ctatcagctg ttttttggta gaagctcctt gttctttcaa 2385721 tgcattcacg atgataattc caaaaacaaa tgctacaagg gcatccagag tgaggtatcc 2385781 ttcctgaaat cctttaaaaa acgcttgtga tgtgtaccct tttgatggtg cttgaatggt 2385841 tccaattggg cgaataagag ctacggctac aagcaatccg ataaatgtca gcttaattgg 2385901 cgtcaaaaat ttaccaacta tatcaatgat ttttgaagga ttgagtgata acaagcatgc 2385961 caatgcgaaa aataatattg taaatatgat caatgagaca gggcttgcat catttgataa 2386021 aaaaggtttt accccaattt caaacgatac gtttcctgat ctcgggatag cgaaaaaagg 2386081 cccgattgcc aaatagagaa tcgtcgtaaa tacaatgcca aacaccgggt gaacacggct 2386141 ggctaacgac tgtaagtttt gtttacccga aaaaacaaat gctgttatag ccagtaatgg 2386201 caatccaact ccggtcacta agaaacctgc attagcgacc catacatttt tcccggccaa 2386261 ttgaccaagc ataggcggaa aaatgagatt tcctgctcca aaaaacaatg caaatagcat 2386321 taatcctata atgatgatat aggaagcaga cacttttttt gacattatat atcctccgat 2386381 taaagtagac acttcttgaa tagccaggaa acattacaga tgctatttgc actggcacag 2386441 tgttgattcc aaaataagct tgtgtcagtt ttatatattt ttatcaagtt aaataaaagc 2386501 atgatcattt tgatcgtttc cgatatcggt taaaaaacca attgcaccaa aaccatataa 2386561 acaacggttc cccccgctat ggaaagaagc atatttttct tccacaagtg aagcagtaca 2386621 acagcagctg ctccaaccaa ttcaggaatg ccatgacttc cagaaagtag actcacatct 2386681 ttcaaacaat aaatgactaa aagcccgatt accgctgatg gcagcacttt accaagatac 2386741 tgtacatatt tcggtgtcgg tttgccagac gggaaaatca tgaatggaag gaaccgtgtc 2386801 agcattgttc caagcacgac cattgcgatg gtgatcattt gctgcgtcat agtcatcgtc 2386861 atacggaaac ctcagctttc tccaatggtt ttctcagaac agtcagtacc cctaaaatgg 2386921 cgagcatagc aggaataata aattggtttc cgccaaaaag gataagactg gctactgaaa 2386981 gtccaagtcc cgtgagagca ctgtaatgct ttttctcttt catccattgt tctatgaata 2387041 tcacaataaa cagagcagtc atcacaaaat caagcccttc ggtattaaac ttcacgtacg 2387101 acccaaaaat acctcctatc gctgcccccg cgacccaata taaatgatta agcagtgtca 2387161 caaaaaacat aaaccagccc ttatcaacat tcgccggaac attagcggta taattgatag 2387221 aaaatgattc atcgcacatt ccgaaaatca gataaagctt tttctttcca gtccccctgt 2387281 acttatccaa catggaaatt ccataaaaca aatgccgggc attgaccatt aacgtcaaaa 2387341 aaagagcatt catagggttg aacgcaccaa gtaaaaaatt cgctgcaaca aactccattg 2387401 agcccgcaaa tatcataaaa ctcatgatga ttggatagat tgcgctaaat cccaaagaat 2387461 gcataaagat cccataagct atccccaaaa ataaaaaccc cgcaaaaatc ggaatggtat 2387521 atgggaatgc agaacgaaat gcagcccata tttgacttct cttattcata tgagtgttta 2387581 tagcaggaga gcttaaatgt aacgattctt tatttttatt caaatcaaca acctcctaca 2387641 tttcatcaat tggcacactg acagttcttt tttctgtact catgactatg cttgtgtcaa 2387701 ctccactaat agcagggttc tgcattaatg aatcaatgat aaaattccga taactctcca 2387761 tgtccttcgc cacaatctta agcatatagt catggcttcc tgtaagtgtg tagcattctt 2387821 gaacctgtgg gaatttgttt atatcctcta aaaatgaatg aattgtctcc ctatttaagg 2387881 gtgataagtt gatgagagct agtgctgtga cttcgattcc aagttttttc tcatcaacaa 2387941 tagtcgtaaa ctttttaatt atacctgctt ctactaggtt ctttgttctt gcaaggcaag 2388001 ctgatggtga aagcccaatt ttcttagata aatttaaatt tgatattgaa gcatcttcct 2388061 gcaaatctct taagatggcc ttatcagttt cgtcaagcat aatacccatt tcacaacccc 2388121 caatacaact taacagaatt atatttcata caatttaaat aataacgaat ttttattcgt 2388181 taatcaaata ttatttaaat ttaaatcctt ttaaagtatt attcacagaa taaaattatc 2388241 ctcgcgatta actcataatg aaattaactt acatcagaaa gaagtcatgg gagagttatg 2388301 tacttgtgtg acttgatacc aacatcataa gaaacttatc agaagccaaa aagttattgc 2388361 ggtctcaccg aaaattgaat ttgcggtgcc ctattgcctt tttccgcgaa cgaaaattgt 2388421 taaaattcgc aaaacagaaa gtctactcta ttattatttt aaattcgtcc tttagttctt 2388481 cttgagcctc ttgtataact tctaatacat cgtcagcgta tgaacctaaa aatgtattgc 2388541 tgaactcaaa atttttcaag actaaagtga gcggcaaatc cacccaccct gtcaggcaat 2388601 cccataaagc gtctaaattt ctcccatagt agtctgggaa gtctagttta tcttttaaat 2388661 catcatgtaa aacttctata ttttcaaagt ctcttccatc tattattatt tttctcatta 2388721 gaaactatgc cctccattat tttatcttaa caaacgttta ctatgtaaca gctgtttgtc 2388781 caaatgaggc tgaaaacaaa taaaaaacac cgataggatg aaactattgg tgtttgcaag 2388841 acatcttcat acccggtagg cataaataat gctaaacttt gtttttaaaa agctatcata 2388901 tcaaattttt atgttacagc ttttactatc gtttaatcta attgaggagt aaaacaagat 2388961 atgtttgaaa atcacatatc ccctaaaaat taaaaactaa tcggcagttc ttcgagtgct 2389021 ctcatcagaa aattcccttt ccatttcatt tgtttctttt cgccttttaa ctgtatattt 2389081 ggacagcggc gtaataaggt ggaaatcgca atctttgctt ctaagcgggc tagctgtgca 2389141 ccaagacaaa aatgattgcc atggccaaaa gcaatatggc ggttgttctt tctttcaata 2389201 tcaaatatgt cggcatttgg aaatatcttt tcatcacggt ttgctgatgc taaagaaatg 2389261 atgatcacat ctttccgttt aatctcctgc ccatgcagta taaacggttc agccgtccag 2389321 cgaattgtcg ttagctcaac agggctgtga aaccgcaatg cttcttctat ggctgaattc 2389381 atcaagtccg gctgctggcg gagcttttct agttgatcat ggtgacacat cagagcatat 2389441 gtcatattgg tgattaagtt tacggttgtt tcatgacctg caacgataag cagcataatc 2389501 atcgagtaca attcttctgt acttaattgt gtgccttcac tttccgcttg aattaatgca 2389561 ctgattaaat ctcctgcagg ttctctcctt tttttgcgaa ctaaggattc cagatattca 2389621 acaaactccc ctaacaagtg gtcattctcc tgaagtcttt caggggcatc tgaaaaatca 2389681 ataattgctt gcgaccatac tctgaatttt tgacgatctt ccaagggaat gccgagcatt 2389741 tcacttatca cgataatcgg caatggaaac gcataatcgt ctactaggtt catgaatttg 2389801 ttgggctgca ctttatccaa taaagaatct gcgatatgct ggattttgtc ttccaactgc 2389861 aaaatcatcc gatgcgtaaa tgctttttga acaagagttc gcaagcggtt gtgatcaggg 2389921 ggatctgaat taagcatatg ttttgttaaa gtctcttcat tcttcaatag agcaggacgt 2389981 ttttcttttg cggtaaatac attttcatag tttttcttta atttttcatt ctttaataaa 2390041 tgtattgcat catcatatct cgatatgagc cagcctttcc ccagagctcc taaagataat 2390101 gggtagagag cctgtgattt tcgcaattct ttataaaatt catacgcttc atctttaaat 2390161 gctctcgaag acaattgact ttccgtcaaa atggttacac tctttttttc ttttgaagac 2390221 attcattcga cctccatctt tgaaaggtta tgataatctt taaatataaa atcaggacga 2390281 tttgtaaaat gatccattga gatcagtatt catgataagg gccaaaatgc cgtccccgca 2390341 ttttgaaata aaagatatga gacagtcatt aatcattttg ctgcctaaac tctttccctg 2390401 ataaaatggc gaaactccta atacttctat gccggctctt ttaaggattt ggaaaatttt 2390461 ttagccccat tttgattaat gttatccccc ctgctgctat ataatcgatc aagtttaatg 2390521 tcgggtttat cacgatgttt taatagagcg gcaacaacca tttcaccatt ctgaatgcca 2390581 acaaaaaaga aatgcttttt aaaatatgct cttgtcagta ctttatgcat ttcaaaaata 2390641 aatgaatgat ctttttttcg cgttttacga gtaaatccat aaaaggatat tgattgaaag 2390701 attgatggaa tagctttgcc actttgctta cttcatctgc tcttgcttgt cgataaagaa 2390761 acattgatgc acctcctctg agcagtaaag caggaaatcg aattaaagcg cccttcctat 2390821 tggaaaggcg cctgccgttt tactgtgcca aaatgttttt catcagtgag tttttataaa 2390881 atcatttatt aattgatcag ttgtcaatat tgtggcaaat tcatcatgca atgtagctag 2390941 agatatatta tgaatagtcg ccgcatcata atatgtatca ttttggtctc tcattccgaa 2391001 ggctgctgtt gcatctgaaa tcaggtatgt atcaaaccct aaattaccac tcattcttgt 2391061 ggtggttgat acacagtgag gcgtggttaa accagttatg actacagtgg ttatttcatt 2391121 taattttaag aattcttcta aattcgtacc aataaagctg ctatttactg tcttggttat 2391181 aatgacttct tcatccatag gcttaactat ttcctttatt gcaaaccctt cattctttgg 2391241 atggaataaa gaatgaggtt tatcagaagt gtgttgtatg tatatgactg tccatccttt 2391301 ttctctccat aattctagta ttttactaat gttttcttcc gcctttacgt tattccgttc 2391361 cccccatttt ttatcatcga aggctttttg tacatccaca atgattaaag ctttcttttc 2391421 ttccacaaga taccctccta cgtagaattt ctatttatta ctacattcta aatacaaatt 2391481 ttacttttgt acaattgttt aatgatgaat ttcaaatgag cgccttcttt attggaaaat 2391541 gcgttctata ctgcaactgt gcccaagccg ttaaccttca aatctaatct gagaatcact 2391601 ggctctacag agaataataa aaaacactct aataacgagt gctgaaatga aaaactattg 2391661 atttagaagc catttgatac gctcagctga aatgatgtag tggagtatta taagacataa 2391721 aaagacaata ctaactggtt ttaaataact aaaataaagc gctgcaacag ccattgcaaa 2391781 gatcaataat tcaataacta accttgttac tccgtttaca gctattacag tttgtccgct 2391841 tcgactagga tcatgaggta ctgcaaatac agaccagaca atcataactg caataggtaa 2391901 aaccaaagtt aaaacatatt taaaataacc attaaagctt atccaagcat acacccctaa 2391961 ggagattagt gcagcaattt caagggtgaa tcttaaaagt aaattagtct gattcagttt 2392021 ttccaactcc tctataaaaa acacccccgc aggagatgct ctttctctgc tttatttcag 2392081 cgtataaaaa cttttctgtt cttcctcttt agattctatt gtagttttcg gcgagattac 2392141 ctctactttt gaagagatga taccgactgc tgctgttacc aatgctccga taatagaacg 2392201 atgataagta taatgaaata tgacaacttt tcccctccta ttcagttaat tatccaaata 2392261 atcaggaagt tgtctacaat ttgcagaatt tgtcgaacga agtaaagatt atacctggga 2392321 ggctttactc attgtatgaa ttacagtaaa taaattgcct tcccttttga gaagacgttc 2392381 caactcagct agactcttcc aataggcttc cttttggcgc agctgctttt attcaaaaat 2392441 tgagcaacac ctgaatgttt cattggaatt tctgaaccat cgatcgctgc tgaatttgtt 2392501 gcaaatgcat acgtaggagt agtcgaatgg tggttgaaaa atgaaatgcc ttccccacct 2392561 cgagtgatgg cagaaaaagc gggggttttg ttagagagga atctatagat atgtgtatcg 2392621 aagatttgac agcattaaaa attatactta catcgttggg aacaggccaa caataaagcg 2392681 gaagaacgtt gtcatttgaa gtggtttgga ataaaaatga ttcgaatatg ttcttatcat 2392741 tgtaaacgaa caaaaaaaga acatgttttg aaaaaagatt gatcaaaaca tcttcttata 2392801 tgttgtcata gcgtaacttt ttataaaaag gttaattaca ttttcggggc ttccaaacca 2392861 aattttgccc attcttcttt tgctggacca taaatacctg gaacagttaa acctgcttgt 2392921 ctcataagaa cagtcatttg tccccgatgg tggttttgat gttgaattaa aaacatcaaa 2392981 agtgaaccgt taggcatttg ttgtccaata aagttgatac gttcttgaag tgtatggtca 2393041 gtccattggg tttttaatgc ctgtacaaat gcattactgg cttgatgata gctgtcagct 2393101 ataaactgag cagaagttgg aacaggataa tcttcagctg gggcttggaa cgttaagtct 2393161 gtgtttgagg taatgatgcc aatggcagca acagtatgcc aagcaatacg gcctagagtc 2393221 caattttgtg aagttatttc ttgtttaagt gattcatcag tcagactatt taatagtttc 2393281 tgtgtagcat ctgcttcgaa ctcccaagat ttcaaaaaat ggtctaaggt ttgaaacaca 2393341 aaaatcctcc ttttcattct tttgtttttt caatgtgctt ataggttaat tataatgcct 2393401 cctttcgtta aaaagaacaa aaatttcgga caagaataat catagtaaaa tgcgtagaca 2393461 ttcttaaacg taacgattta cgcatctttt tacaaacatc tgactacttg gtctccattg 2393521 tcagcgagaa tcaaatatca tatgaagaca atcctatatt cttatcactt tactgagcaa 2393581 taaatacctt ccgtatactt agtaatacct tcatcgtaat caggatactt atatgcaaga 2393641 ccttctgata cagcttttga atactttcta aataatgcat agcaagtaaa taaagacttc 2393701 cacatttcct gatacccatt cacagaatat gtagacatga gttcctccca ttctttattt 2393761 gaaaggtacc gcttcataaa tttatagttc ttccccatac taaatgaata ccctttctga 2393821 gatgcgatat gccaggccat cattctcaat aaattaggac gtacaatttc atttaaatgg 2393881 tcaatggcaa aaaggatttc atttcttgct agtcctttta ctacgtaagt cgaaaccatc 2393941 cagaactcat tacagcaatc atcaaattcc cttgcagtcg gcctttttat ccagtattgg 2394001 cgatcatttg gggtcacttt atagttgatg aacgaatcct tatcaagcaa taccttaacc 2394061 aaaccatcgt tattagcaaa ataatcttct gcttcacgaa ttggaataag ggttagatct 2394121 aatttgttgc catcctcaaa aagaataatg tatgaaaacc aattacctaa ttcgggagga 2394181 aaaagctcca tatcttctgg tttttgcatc ataatgcgct tcccaaagat ttcgagccac 2394241 tgatcatttt ctttaaaaga ttctacatca gttacaaaat acgagatgtc ataatcttgg 2394301 aagttgtcag gagggatatt tctgtttgta cgtgaccctt ccaaagtgac caatcggatt 2394361 ctctcatcgt tcaaagcaaa gtccaaaaaa atgtccatca tttcctgctc acttcgcatt 2394421 acatgttcct ccgtttcagc cttaatatct aactgtaaaa cgtcttatag atttttttac 2394481 tcttgaatgt gatgtattct tctaagcttt attttacatg atgttctcct atatatcatt 2394541 caatattaag atgcaagaca tctcaaaatc agatatcaac tatgacggac tacatgaata 2394601 ttcagttttt tgtagagccg ccatgggacg acactatctt tgacacactt taatcccccc 2394661 tgctttatcg acatgttaac tggtatgaga gattgacaaa aagaaggaaa acgatatatt 2394721 taagcgaata cgagtttttg agtaaatttt aaaatgacac ttttttcaaa aatcatgtct 2394781 taacgggagg attcggtatg aatgaattta tgaaaaagtt ttctttaaca aaaccgatta 2394841 ttcaagctcc aatggctggc ggtattacaa agccccgact tgcatctgca gtttcgaatc 2394901 aaggtgctct tggcagctta gcatcggggt atcttacgcc agacctccta gaacaacaaa 2394961 taaaagaaat atttgagctg acagacgctc cttttcaaat taatgtgttt gttccgctag 2395021 gtctagagat gccaccaaaa gatcagatta aaaagtggaa agaaaacata ccgttagcta 2395081 atcaagtaaa tcaattcaca tctgtacaag aagagtggga tgacttctat caaaaaattg 2395141 atctaatttt aaaatacaag gttaaggctt gctcattcac ttttgatctg ccgcctgaag 2395201 acgcagtaaa ggagctaaaa accgctggat gctgtttaat aggaaccgct tcaacagtag 2395261 aagaagcatt gttaatggaa gaacggggaa tggatatagt agtccttcaa ggaagtgaag 2395321 ccggtggaca tcgcggagca ttcttacctt ccaaaggtga atctgccgta ggtttaatgg 2395381 ctctgattcc acaagcagca gatgcactga gcgtacctgt catagctgct gggggaatga 2395441 tagaccacag aggagtaaaa gcagctttaa ccctcggagc ccaaggcgtt caaatcggtt 2395501 ctgccttttt aatttgtcac gagagtaacg cacatccagt gcataaacag aaaatactag 2395561 aagcaaacga agcagataca aagcttacga cattattttc aggtaaagag gccagaggaa 2395621 tcgtaaataa atggatggaa gaaaatgaac agtttgagac acaaaccctt ccgtaccctt 2395681 atcaaaatac actaacgaag gcaatgagac agaaggcttc acttcaaaat aaccatgatc 2395741 agatgtcttt atgggcaggt caagggatac ggtcattgac tgaggaaatt tcggttaagc 2395801 agcttttaaa tcagctttgc caagaggata taaaaatata ggcgcacctc attgatagag 2395861 caaaaagcaa actttgacag gcagtttgct ttttttttcg taatttcatc cactgactct 2395921 ggaaatctaa atactcctac attttcaaag ctaatttgaa tcgggttatc aatcatcaca 2395981 ttgatacgat gcgatcttga taatttcacc acaaccacaa tacattacca acatttcgat 2396041 cttatctccc cttctcaagt tttgctccct attcgaataa tcgatagctc ccatattaaa 2396101 tttgaatagt aaaatggttc tttttcgttt gattcagatg atataaagtc atatgataaa 2396161 aaaagaatga gacagaaagc gtgagaagtg atgaaaatag gattttttga ttcaggaatt 2396221 ggtggcatga ctgtattgta tgaggccata aaagttcttc cttatgaaga ttacattttt 2396281 tatgcagata cgttaaacgt tccatacggt gaaaaatcaa agggtaaagt taaagaatat 2396341 attttcaatg cagctgaatt tctggccagt caaaatatca aagctcttgt tattgcgtgt 2396401 aatacagcta ctagcattgc gatagaggat cttcggagaa acttcgactt tccgataatc 2396461 ggaatcgaac ccgctgtaaa gcctgctata aataaatgta cagaggaaag aaaaagagtt 2396521 ctggtagttg ctactaattt gacgcttaaa gaagagaaat ttcataatct agttaaagaa 2396581 attgatcacc atgaccttgt tgattgctta gctcttccag gactagttga atttgctgag 2396641 aactttgatt ttagtgaaga caaaatcatt aaatatctaa agaacgaact atcttctttt 2396701 gatctgaaac aatatggaac gattgtgtta ggatgcactc attttccgtt tttcaaaaac 2396761 agttttgaaa aactgtttgg gataaaagtt gatatgattt caggcagtgt cggtactgca 2396821 aaacagttga aaaaagttct tgcagatcgt aaccagcttg gtaaaggatc gggctcaatc 2396881 acctttttca attctggcca taaaattgtg gaccaagaag tcatatcaaa gtacaaaaga 2396941 ttgtttgaaa tattagatga aactcaaagg agtcatgttg gacattgaat gtaaatgaaa 2397001 aagacaatct cctgaagaga aacatgaact aagaagcggg cttaaaaagc ccactttttt 2397061 tctaacaaac aattgagtta tacacacata tctgattaca gtgttttctc tctttcccct 2397121 cttatttctc ccccctctct atagcttttc tatttcaata aaacacaagt ctcgattgaa 2397181 aagttatcgt aacatttaca cttcacagga gatttttcac gattgcgaat cgaccgtttg 2397241 ccagatgcac aaagtcataa tgtgtaaatt ctgtatctat gtgcatgttt attatggaat 2397301 tattttcata atgttttata atacaagatg atagcgtttt ctaattataa tgataggggg 2397361 aaataatgat gatgaaaaaa ggtctgcttg cgggtgcgct tacggcaacc gtgctttttg 2397421 gcacatgtgc agtagatgta ccgggtatta ttagtccaaa aaccgcagaa gctgcatcac 2397481 agctaactga tggaatcggc gggagggctt acttgaacag taatggtgcc attcttgtta 2397541 cgaaaatcca gcttcctagc tccactcagg tttcaaatgg gacagcctac atctactctg 2397601 gttttagcgg aggcacagaa tccgatatcg ggtttcagta cagtgataaa tataatgtat 2397661 ggaaaccata tatgaaagtc ggttcaaaag gacaggatca ggttcagtac ctcgaaggag 2397721 gaagccaatt cacgaatacg aaaggcttcc gtcccggcag caccgtacaa cttaccatct 2397781 acaaaaacct taacggcaat acccgcgcta catactgggg cacgaacaat gccggataca 2397841 acggccgtct catttcagaa atcagcaaaa caaatgtcgg ctccatctca aaatggaaag 2397901 cgctcgctac agttgcaaca acagggtcac gccaatctat caaatcaaac ttttcaacat 2397961 cttttacaaa catcaccatc gacaacaaag caataacacc tgtaattgat acacaagact 2398021 tcgctaaagt aacagtctca ggcaacagtg tcagtttatc cgttgtcaaa aattaaaaca 2398081 tgttaaacat acaatgcgtt aggctattga gaagctctcg atagtcttaa agggggctta 2398141 acatgcccct tttttcattt caatttaact ttcagttagc ttcggtacat gccgtctatc 2398201 cccgtctttt atctgggtga agtaagggca gctcgcccct tctgaacctg ttccatttgc 2398261 tcaacgcaaa aggtgtgcat cactgtctta aaaatgttaa aacaaatagc agatggtgca 2398321 ctttattttt agatgaggca tgcttacgct cgatatgcaa gtcaaatgat taagggtctg 2398381 caagagagag aagttttggg tgtactttca taaaagaggg atggcttcat atagctcgat 2398441 tgcatcagga agattagcca acgattggcc gagaacaaca catcactttg aaacggattc 2398501 attccaaaat cataagtatg atccaataac taataaagat cagttagcag tccagcctta 2398561 aaaatatttt tacatcaatt aaactagcat cactatcgaa taagctcgat ctgcatatca 2398621 tgtactatcc tcttttaagg aaggtgatgt tatgaggtca tttccattaa tcgtagttct 2398681 attcatccta ttaatcatcg ttgggacatc tttctttggt ggctattaag aacacacctt 2398741 acctcatatc catcagacgc cataagaaat ctttatggcg tctgtttttt attagattta 2398801 aacaaaacca ttaaagtggg ccatgcaaac acacctatgg agattactgc cacgacttct 2398861 ttgtgaggga attattcttc cctttatgga ctattgtcga tcaaaagaga aagttgaaat 2398921 gcatttttat ggtgagatga atcgaggctt agacatataa aaaaccgcaa agctttcttg 2398981 aagaagcttt gcggtttttg ggtctcttct ttgcttcata taagccaata gatttcaagc 2399041 gtaatccact gccatacatc caatgatttt ttattttgaa ataggtttct tctactcttc 2399101 atgtgagatg actcaaggta tgccacgtca caataatatg gcggatactg aatggtctca 2399161 atcagttttt tccccattct atcaattctc cacagaaaaa atggctatgg cagaacaact 2399221 ttcatagagt aatcatcatt taatgagcca tcatctcatg ggcaatatcg tgtccatcca 2399281 tttttgacgg gtagtaagta ggccagtttt tgacttcatc aagtaaagct tcacggtcgt 2399341 ccccccaata gagatggtaa tgactagctt tagtcgggta aatactatga tcactaaact 2399401 gaatatactg aggcagccct tctgcttttt tagctagttt gaatatgtat cttacccctc 2399461 tattgcccgc atcataggtt agaatttcgt atccgtcata cgtatactta ccagaatatt 2399521 cttttccatt tttgaagaac gttacagtat ctttctggat tacaatacgg tcaacatctg 2399581 tttgatagcc ttttttataa tactctttat attcttcagc tgtcttgccg ccttcgtgtt 2399641 ctgatttata tgaaaacact tcgtcaagag taccatcttg caggtatgga tatacagatt 2399701 gccaatctcc ttcccaatca gaaagtaagc gatcctttac ttggctgttt ttaaaatagc 2399761 cttcatatat tttttctgtt tcttcatcat gcgcatgact atgatcgtga gaatgttcgt 2399821 gtgtatgact gtcagatgtt tgctcttgcg ttttggaaga gtcttcttca actgctgagg 2399881 atgatgttgt ttgattagac tcacctgcag aagaaccgga agtctgacat cctgccaaaa 2399941 ctagtaatga accaatcgtt aatatgccta gccgttttga aaataaaatg ttcattccaa 2400001 cactcctttt ttattaaatc gaaaacatta cgatttatta tacatacatc tcttgcaaac 2400061 atcaaaggaa aaatgctctt catgcggatg gcctatttta aaggaataac tgactatgtt 2400121 catcagttat tcctttaaaa tacgaaagtc tacgatattt ccatatcgat ccgcttcaat 2400181 gtgacagcac ccctcaagca gctgttttaa ttttccacgt ccgcgttgta cccttgattt 2400241 tgctccggag taagaaatgc cgagcttttc actcaactct ttttgtgata acccctggaa 2400301 atcagttaac tcgagcgcct ctcgatactt ttcaggcaac cgtttgatgg tcgatcgaat 2400361 acacacagtt gcttccttgg tgaaattttc ttcctctgca ctgtcattaa aatgtagaac 2400421 atcaggcaat atttcgcttg ttttttttgt acggtaaaaa tcaataatcg tatttctagt 2400481 gatccgataa atccagctgt cgatcttttg ttcatcgatc agatttggga gatgcacttg 2400541 tattttcata aatacgattt gcaagaggtc atcaacgata gattgatcgt taaccctatg 2400601 tgaaatatat gtttttaacg gctgatgaaa ttgatcccat agatcctcta tattcatttg 2400661 aaaaaacctc ctataatttt gcgtctgctt tacatttgct tcgtcttttt aatcgtaaca 2400721 aagagcaaac aattgttgaa tcaattgtat tgcagctgtt gccaaaaata atgataaagg 2400781 agaggtttgt tgtggagtat acctatttag ggagaacagg attgcgggtg agccgtttat 2400841 gtttaggcac gatgaatttt ggagttgata cagacgaaaa gactgcgttc cgtatcatgg 2400901 atgaagcact tgataacggc attcaatttt ttgatactgc caatatttac ggctggggca 2400961 aaaacgcagg attgacagag agcatcattg gaaaatggtt tgcacaagga ggacagcgcc 2401021 gcgagaaagt tgttctggcg acaaaagtat atgaaccgat ttctgatccg aatgacggac 2401081 caaatgatat gaggggcttg tctctataca aaatcagacg tcatctggaa ggatcactga 2401141 agcggcttca gacagatcat atcgaattgt accaaatgca tcatatcgat aggcggacac 2401201 cgtgggatga gatatgggaa gcttttgaga ctcaggttcg ctccggcaaa gtagactata 2401261 ttggatccag taattttgca ggctggcatt tagttaaagc gcaagctgaa gctgaaaaac 2401321 ggcgattcat gggactcgtc actgaacagc ataagtatag tttattagaa cgaacagctg 2401381 aaatggaagt gctgccggct gcacgggatc ttggtttagg agtagtggcg tggagtcccc 2401441 ttgcaggagg gcttcttggc gggaaggcat tgaaaagcaa tgccggaact cgtacagcaa 2401501 aaagagcaga tttaattgaa aaacatcgtt tgcaactcga gaaattttca gatttatgca 2401561 aagaactagg agaaaaagaa gcaaatgtgg ctttggcatg ggtgctggca aatccagttt 2401621 taactgcgcc gatcatcgga ccacgaacgg ttgagcagct gcgtgatacg ataaaagccg 2401681 ttgaaatcag tctggataag gagattctcc gcatgttaaa tgatatcttt cccggacctg 2401741 gaggagagac acctgaggca tacgcctggt gatacattca ttactcaata ctgacatttt 2401801 tcttaaatat ttatactgaa ctatcatatt aagaaagaca agagcatgtt tgtctcttgt 2401861 cttttccaca tcgtgctgaa aatgctggct aaacatcgac aaaaatgctg ccgcttaaaa 2401921 aagaacccta aacaatagag taactggaaa gacaactggc ttgatcagct tgggacccct 2401981 ttcagctgta tttaaatcaa tcaaactaat gattcattgg cagtctaaat attattattg 2402041 tttctttaca aaatagtaat agcccctgta atgattgcta acaacgtaat aactaatgat 2402101 gtaattacag cccacttaac ggcaaacctt tgaaatgacc ccaagtccat tttaagcatg 2402161 cttactagca atactgttga cgcaaccaat ggactcatca gatgaaccgg ctgccccatt 2402221 atagaagccc ttgcaatttc tactggttct ataccatatg ctgaggcagc ttctgcaaag 2402281 ataggtacca taccaaagta atatgcatca tttgataaaa caaaagtaaa cggaatacta 2402341 gtgagtgcta caataacggg gaaaaaccct cccattgatg aggggatgat ggatattaat 2402401 gatcctgcta tggcatccac catctttgtc ccggataata taccagcaaa tactcctgct 2402461 gaaaatacca ataataccac ggttatggca ttaccagaat gctcggcgat tcgctccttc 2402521 tgcattttta cattcggata atttatagta agggcaagaa caaaaccaat taaaaataaa 2402581 actgacggat gcttagttcc aagcacaata aacaccatga tacttataac gaggaataaa 2402641 ttaagatata ttaagcgtgg ccttttcaat tgttcgctct ccaaagtagc agccatataa 2402701 gattgagagc tgtcctttgt tatatgtcta ggctctaatt gaacgatgcc tattcgattc 2402761 ctctctttcc ttcccattag aaaagccaga aatatcacac aagcaatacc tccaagcatg 2402821 gtcggaagta atggcacaaa gaaatctgaa ggatccaaac ccagcactga aatcgctctt 2402881 gtagctggtc cgccccatgg agtcattccg ctaacgatac tcaacgacag cattgctaat 2402941 gtcgccataa ccatgggatt cataccaatt cttttataca aaggtaacat tgctgagact 2403001 gttatcatat aggttgttgt accgtcccca tctaaagcga taagcattgc caagacggca 2403061 gaccctatcg ctattttcac agggtctccc tttactatag ataaaatttt ttctattagc 2403121 ggatcaaata aacctgcatc aattaaaatt ccgaaaaaaa gaatagcaaa caatagcaat 2403181 gccgctgaac ttgcaactgt ttgaattcct tctaaaatca tgtcgccaat acccttacca 2403241 aaacctccaa taagagcaaa aacaatggga gtgatggtca aggcaacaat aggcgagact 2403301 ttctttgtca ttattaatat tgtaaaaaca gttaccatcg aaaaacctaa aatagtaagc 2403361 atattacacc tccaagaatg cgctttcaaa tgacttttga ttaacatatc ttatacggtg 2403421 taataagtta aataaatatt tttttactgt gtttcaaaaa aaattctatc ataactttaa 2403481 atggttacca tttgttcacc ctttaaaaaa tcaatgaatg ctttaacgag tttgattcct 2403541 aatgattttt gatcgtacat tagccaagta tctctcatta gaggcttacc cttagcatta 2403601 tacagttcca ttgtgtacaa atgatcagat tcctgcaggc aaatttctgg tgctatggag 2403661 taaccaagac catgctttac catctctttg caagtctctt gtcgatccac ttccattgca 2403721 ataatggggg cttgttttag attcgtatgc atccaatctt ctataatcgt ttttaaagaa 2403781 gcatccgttt tatatttgat aaaaggtaaa aaaggaagtt gctctatcgt tattggtttt 2403841 tttgagatga tatgtaattt ttcccgtgtc agccgttcct ccaccccttt ccagcgatgg 2403901 cttcctctca gtataccgac ttgtacaata ccagcatcta ataatttcat gacatctgtg 2403961 ctccagcctg tttgtacact atattggaca ttaggataca tagtggaaaa ttcccttaat 2404021 aacttaggga gcttatattg agcgaaattg cttgataccc ccagccttag atgtccttgc 2404081 acctctttgc ttagattaga gatatgatct ttggtatctt gaagttcctg tagcattctt 2404141 cttgcataag caaccaagtg ttctccttcc gcagtaaagg taattccttt atgccttttg 2404201 gtgaataatt caattccgaa aatctcctca atctttttca accgataagt gatggaaggc 2404261 tgtgatgtaa ataatcgttc tgctgttttt gttacacttt gttcttcgtg aagaattttc 2404321 aataaaatcc aatctttctc atccattttc atcttccttt ctagtccttc tttcacaatt 2404381 ataaaagttt ttttatcgaa tattaagaaa acttatattt tatttttatt tttttacctt 2404441 ctacactaaa aaacataaaa aatactacct ttaagatgag gatgatgacg atggtcaaga 2404501 cgaatgtaac aatcatgaga ggcggaacaa gcaaaggcgt ttttttccac gaatcagcca 2404561 tgcctaacaa taaaaacgaa tgggagccct ttttgcttga tgtcatggga agtcctgata 2404621 aaagacaaat agatggtttg ggtggcggta attcccttac tagtaaagtg gcaataataa 2404681 agaaagcata tacttcggat attgatgttc actatacttt cggtcaagtc agcatttcgg 2404741 aagaaaaggt ggactttaag gggaactgcg gaaatatctc cgctgctgtt ggtccatttg 2404801 ctattgaaga aggacttgta aaagcgaaag aaccaatgac tgcggtaagg atcctgaata 2404861 ccaatacgaa taaaatgatc attgcggaag tagaagtgga agacggtcag gtcaaatatg 2404921 acggagatgt tacgatatct ggagtacctg gatctggatc tccaatctat ttaaactttc 2404981 atgatgccgc tggttcagtt accggtcatt tattgcctac tggaaatagt tcggagtttt 2405041 tagatacaag tcaaggccaa atagaggtgt ctattatcga ctatgcaaat ccattagttt 2405101 ttgtggaagc gagcagtatc ggcctggatg gaacggaact tgcagaagaa tttactgatc 2405161 tacagttggc tcaatttgaa gaattaagat ccattgcggc agagaaatgc ggctttgcca 2405221 gtcgattttc agctacaaag ttatcgccgg ctgtccccaa actggctata gtagcaaaac 2405281 cagagaaata taaagatagt acaggtgctt ggcattcaag cgttgagatg gacttacaca 2405341 tcaggatgat gtccatgcaa aagccacatc aagcactggc tgtcactgga gcgatatgta 2405401 caacaagagc cctttcagtg gaaggtgcaa tccctgcaag aatagcaaaa aaccactcta 2405461 caaaggttcg gctagctcat tcttctggta ttattgaaac aatggtggag cccactggta 2405521 taaagatcgt ccgtaccgca cgacgtatta tggacggaac agtttatacg catggagact 2405581 atcaaatgat gtagatggac tgtgcaaaaa gcctcccccc tttccatcgt taatagatgg 2405641 attgaatgcg ccttcttgca cagatccatt gtaatcttgc atggctttaa aaaagcctct 2405701 atattgtttt ttatgaaatc gccaaggtcc tttcatgtat ctgcctcaag catgacataa 2405761 tcattataga gaaaattgaa tactttttac tgcaaataaa aagataccaa catcattggt 2405821 atcttttaga ttgagttcat ctgcagcggt ttcttttcct cactgcttat ttgattacaa 2405881 aattaccgta ctcgtttgaa cgaacatgaa tcggtccgtt tagattatag ttgttctcct 2405941 tggcgataga gcgaagcacg tccacacggg caactgattc tctccattcg tcacgggtgt 2406001 catgattggc cggattcatc agatcgtcat agcgtacgtc caagaattta ttcaaccact 2406061 tcttctcgtc tattccgtct ttaggtgatc cgcccgcttt tttgttcgta cgtttaatca 2406121 aggcataaaa agagtcaggg tcatcaccat cgccatgctg aataaccgta tcgtacatca 2406181 cagctcttgc caatgctgtt tttagtccgg cattatccga tcgtttcatg gcaggctgat 2406241 aatacaaatg gtcatttact ttgtcttgag cggcgcgaaa ttccttatca tttgcaagcg 2406301 acttccaggc agaagcgaat cccttgagat tgcttgtatc atcgctttct tccttggcca 2406361 gacggcgcaa ttcaggcaga tactttttca gtttgttatt cggaactgcc tttgtgtata 2406421 cttccactac ttccaatgca tccccggtag ccgttgtaaa gcctgcccgt ccgcatgtat 2406481 agcctcgccc gtcatccaat cgctctacat atccatattg gatctccgtt gtgccgtttt 2406541 caaagatact tgtcagctgt tccgcccggc gcttttgatc tttattcagt cccgccgcaa 2406601 aaaccgtttc gctcatcatc agggtaaaaa acatggtgaa aacaagtaat gagatcgctg 2406661 cttttttcca aaaatctgct ttttgcatac tgattttcat ttcacttccc ctttctaaat 2406721 attgtaaata cagactcagt atacatgaag aaactgccct attgttgaaa atacatcaat 2406781 ttgtcaatat tttgaatcta aagtaatata gcttgaatct tactctattc attgccaatc 2406841 agccttagcc cctctcactg ggaaggtccc ttgattttca tactgcttca actttcatta 2406901 acaagatgcc ataaggcttt actctatttt ataatggaag tgatcatcga aaatcgttag 2406961 ggaggtgatg taatggcaag caagatgaga atgccagatt ccgcaacgtc ccatgcaaag 2407021 cctactattg ggaaggcgat actttgcatg gggtagactt tctaaaagat cgcccaagta 2407081 agcttttctg atatagtggc tttgcacctt atttgacata aaaaaataag gagctggcag 2407141 aaatggcata tgtaaaagca accgctattt tacctgaaaa gctgatatcg gaaattcaaa 2407201 agtatgttca aggaaaaaca atatatatcc ctaaacctga atcctctcat caaaaatggg 2407261 gtgcgtgttc aggaacaaga aagctgatcg atgacagaaa cgcttctatt aaaaaagcat 2407321 ttaaaaacgg caaaaccatt catcaattat ctgatgaata tcacctctct attgaaacaa 2407381 taaaaaaaat tgtctactct aaataaacaa aacggaagca ctgataaaaa ataatcagtg 2407441 ctttttatat ggcgagtttg tttcttagtt atttcctgca tatgatacca ttggccaatt 2407501 gtgtaaagtt aagggagatg agaagaaagg aaggtcctac aaatgacgat aaacaatgga 2407561 acgttgcaag tacccggcgc gaacatccac tatcaggtgc gtggctctgg tccaatcatt 2407621 cttttggtcc acggaggagg cggtgatgcc gacaagttcc atcatgttgc caatcatctg 2407681 gctaactggt acacggttgt tacttatgat cgccgcggcc attcccgcag caatctcgcc 2407741 aatcagattg agggttaccg tgtggaaaca cacagtgacg atgctcaccg tcttctagcc 2407801 aaaatcacca ataagccggc ctatgtattt ggaagcagct ccggggctgt tatcgggctt 2407861 gatctgtgca tacgccatcc cgaacaagta catgtcatga tcccacacga accaatctta 2407921 ttgcagcttc tgcatggaaa tgagctgaaa caagccgagc aattcatgga agaccttaag 2407981 aaaaatcatc gaagtgaagt cattaaatta atgtcaagat tagagacaga cgaacaatca 2408041 aaggctgtcc tgacaaagcg gcttctcggc aattcaacgt atttcactga gtatgaaatt 2408101 caaggaattc tcagctatac attagatttc gaagcattaa aaactgtgtt tacatcttca 2408161 ccgatgaaga tactcccagc tggcggaagt gcttctcggg agctttttcc ttatcgttgc 2408221 gcgaacgccc tagcggaaca attggaaaca gaatgggttg aattccccgg aaatcatacg 2408281 gggtacacaa tgtaccataa agaattttct gagaggttac acgacatgtt agaaaaagaa 2408341 aagaaacata cgtgttaagg attgattaaa attttcaaaa taggacaggt gaaactaact 2408401 atggaattgg agaagatttc acgaagcgta aaaagaactt ttcactaacg agaacgcaat 2408461 gtgagatgtt taaccaaagt gatattaggg atttcatcga aaaataggtt tgtacattac 2408521 gttctcctat tgattatttc ctatcttaat tccgtatttt ataccattag atacaactct 2408581 aaagcggctc gttattttgt cctcaacaac aaccagtgtc taacatcatg aatctctttt 2408641 gaaaatcacc acaaatgcag gtatggaaga cttcatcgca gcaaaaacca taccaactat 2408701 tgttgttggt atggttcgtc ctagataggc ccttaagaag agattctatt gtacggagta 2408761 tttagctaat tgcatttgta accgacaggg ccgtctgaac ctgtgtacac atatgtgtca 2408821 gacacatatc caatattcac gacaccccgg gaatctttcc actggatttg gtcccagata 2408881 ttactcgttc catacttccc tgtaacagtc gttccataag cgtaacaata ataaggaaca 2408941 cgggagccac tcggaatgga aagcataata ggataatttg taccaggacc gctgcgcata 2409001 ttgacaggcg caccgctgct tgttgagaca gtaaagtact gaacggcaag tgcctgactg 2409061 gaaaaaatga ataaagatgc aatcatcacg gttaacatac tcagcatttt cagtttagtc 2409121 aatgtcatcc ctctttcttc aattccttca ttttaagaaa cgatagaaca taggctacca 2409181 gctgcattta ggaacaaccg gaccgtctga gcctgtatac atatatgtat cagagacaaa 2409241 tccaggaacg atctccccgc tggcaagcgt ccgctctgtg taattccaaa tattgctcgt 2409301 tccatacttt ccagttacag ttgtaccggt tttgtagcaa tagatcggga tgcgggttcc 2409361 gctcggaatg gtcgttacaa ttccccaact tgtacctggg ccgctgcgca tgttgacagg 2409421 agcaccgctg cttgttgaaa ccgtataata ctgagccgca agtgcatggc tagaaaaaat 2409481 gaacacagat gcaatcatca ccgttagcat acttagcctc tttaacttat tcaccttata 2409541 ccctcccctt ataaatgccg tacgtttgac tttcttacat ccagttaagg atttactttc 2409601 agataccatg ccccctcccc tcccatatat ttatcaatgt accataaact agatctttca 2409661 aaagtggaat tattcctatg ttttcgacaa ttaaggatac aaaataaatg gtagtcaggc 2409721 ttgatattga tggtgtgtta catttggctc ttaatcattt gtccagtcgg taatcacgat 2409781 tgacaatcag gaaaaaggac atggatcaag cggcttcgtt tccaccaatt aactcaatca 2409841 gtgtactgct tccttgtatc cacgcttctt ctcgattcat agatactcca cctttttcac 2409901 caatcaaaaa cggacaccat acaaatcagc gtaaatgctg caagttcagt gtccgcaacc 2409961 tattatgact ttgctttctt ttaccagggc gtgtaaaaat gattaggtac gttatcaaac 2410021 gttattctat gattttgcga gtcaaaaaat cataacattt tatatatttc aatcagatta 2410081 tgatctggat ctctgaagtg agcaactcgg gcactccatt ccttgcgatc atgcggttta 2410141 ttctcacatt taactccttt ttcgtgtaaa tcgtcatacg ttttatcaac atcttctacc 2410201 ttaaactgaa gcaaaaattt tgattgagct tctccttcca aggacttttt ttcctctcca 2410261 acgatttcag ccatcgtttc tcgagataaa agctctattt tcgtttcccc attatcaaag 2410321 agtgcatatt ccatttcatt ctctaaccaa cttattggaa gtcctaatga atctttataa 2410381 aactcgacgc ttttcttaaa atcattcacc aacagtctaa tttgtaacag cttcatatcg 2410441 agtgcctcct ataaaaccat acttttactg gtcatccaat ttaatgatac caaagaaacc 2410501 tgacagcact atgtcaagtt tccatacttc acccttattt cagatttaag tgcagtttag 2410561 tccatgtcat aagaacgagc aaaaacagcg attcttaaaa caaaaaatga taccgagtgt 2410621 attttctgta tgcttcaact tcatttcggg aaatgtaacg ttgataaaag gaggttacat 2410681 caatatggat catcaaacat tggcagctca tgaggctgtt gacttacatg aaatcgtgaa 2410741 ctttaaaaca ctttgtatag cgaaatcaaa gttaatgcaa gggcttgtgt ttgaccaaga 2410801 actgaaggac ttgatggaaa aagatgtaca gcaatccatt caagacctta ctgaattaca 2410861 agcggtttat gagcgtgcct catttcaggc ccctgtccct caaagccgcc caacgccaat 2410921 catcaattga aagggaggta agcctctttg aataatgatc atttagaccc cattaattcg 2410981 ctgaatgtgc ctgaactagc agacactaca ttcgcgatgg attttcttat acgagctaag 2411041 gaaggcgtaa ggaatactgc tgtagctttg acagaaaccg cttcaccaga tgtaagagca 2411101 ctgcttcgga aacagctgat gcaaggaatt gcgatgcacc aagagattac ggaactgatg 2411161 atcagcaaaa agtggttcca tccatatgag ctgagcgaac agtataagct ggatcagctc 2411221 tctgcaaaaa acacgatcat ggtcggcaat atgaacctct ttcctgatga aacaaatcgc 2411281 aaagggatgt ttgaccggac acctgatgaa cactaacact ggaggtttta cagcatgaag 2411341 gcagtaacgt atcaaggcat taaaaatgtt gttgtcaaag atgtccccga tccaaagatt 2411401 gaaaaatccg atgacatgat tatcaaagtc accagtacag ccatttgcgg atcagattta 2411461 catttaatcc atggattcat tccgaatatg caagaagact atgtcatcgg ccatgaaccg 2411521 atgggaatcg tcgaagaagt tggttctggg gtgactaaac taaaaaaggg agatcgggta 2411581 attattccct ttaatatagc atgcggggaa tgcttttttt gtaaaaacca gctggaaagc 2411641 caatgtgatc agtctaatga caatggggaa atgggtgctt atttcggcta ttcagggcaa 2411701 actggcggtt atccaggcgg gcaagctgaa tatttaagag tgccgtttgc gaattttacc 2411761 cattttaaaa tccctgaatc ttgtgaggaa cccgatgaga aattaagcgt gattgccgat 2411821 gccatgacca ccggcttttg gagtgtggat aatgccggcg taaaaaaagg cgatacagtt 2411881 atcgttctcg gctgcggacc agtcggcctg tttgctcaaa agttttgttg gctaaaaggc 2411941 gcaaaacgcg tcatagcagt tgactatgta aactatcgct tacagcatgc gaaacgtaca 2412001 aacaaagtag aaatcgttaa ttttgaagac catgagaata cagggaatta tttaaaggaa 2412061 atcacgaaag gcggagcgga tgtagtcatt gacgctgttg ggatggatgg taaaatgagc 2412121 gatctcgagt tccttgccag cggcttaaag cttcatggcg gaacgatgag tgcattggtc 2412181 attgcttccc aagctgttcg caaaggagga accatacaaa ttacaggtgt gtatggaggc 2412241 agatataacg gttttccgtt aggagatatt atgcagcgaa acgtcaatat acgctctgga 2412301 caggctccag tgatccacta tatgccgtac atgtttgaac tagtatcgac aggcaaaatt 2412361 gatccgggag atgttgtcag ccatgtcctg ccgcttagtg aagccaagca tggctatgac 2412421 atttttgatt caaaaatgga tgattgtatc aaagttgtgt taaagcctta aaaaacggag 2412481 gttacagaaa tggaatacgc cttacacgaa gtgcttgagg ttcaggaaat gactgcattt 2412541 aagacacttt gtttgacgaa atctaaaaca atgaaagcac tggtatctga tccgaagctg 2412601 aaagaaatca tgcagcaaga tgttgatatc accacacgcc agttgcagga atttgcctct 2412661 attttatcta atgcaaagca agaatgagga gatgaataaa tcatgaatcc tatcatagaa 2412721 tatctgactg gcatgaatgt tctaacagac caaatcattg ctatggactt attaatttca 2412781 gcaaagaacg gagtcagaaa ttatgcgatg gcagccactg aagccggaac gcctgaagta 2412841 aaagaggtcc ttatccgcca tttggaagaa gcactcgata tgcacgaaca actctcaagc 2412901 tatatgatgg aaaaaggctg gtaccatcct tggaaccctg acgaacaagt caagctgaat 2412961 ttaaaaaata ttgatacagc cattcaattg ccaacccttt aacatacaat gactgatttg 2413021 ctgaggaaca gtattgattg gccacaactg ttcctcagct tcaaaatgag cactgtttgt 2413081 tcgggtccta tgaccgtaaa tagattaacc gcttttctcc atctgatctc cgataatgtt 2413141 tgcaaattct ccaatccaaa taaggaatcg taaccacctc tttttatgcg atctcttgat 2413201 ggagaaaaca ggccagaaac aaaatccttc gtttttgacc tgccctcttc acacgcaaag 2413261 aatgctacct tctttgctcc actgatccgt gaagactttc cgttttaggc ctgcttttga 2413321 gctttgcctc attttcacgc aatttcccat cataatcttt aatttttgtg tctaatctct 2413381 taattgtttc atcaatttct ttccgcttct ctatcagccg ctgtcgttcg tcagccagga 2413441 tattttttcg agcttctacc gtacggtcac cttcggtaaa taatgttgta tattcaatta 2413501 gcgcttctat cgatagtccc gcatttcgca tgcatttaat gaattcaatc catttgatat 2413561 cttcttcatc atagtcgcga atgccgctgt cttttcgttt tacaggcggg attaatccta 2413621 cacgttcgta atatcggagt gttgcggctg tcaggccaaa ctgctttgcc acctgagcaa 2413681 tattcatgat cttcacctct ctatcctgta tgttgtgaag gtaacactta aagttaactt 2413741 taagtcaagc tcaaaacaag tggttagctg ctgaatctgg gtttatatat tcgggacttg 2413801 ccttaaagca cactttaaac tctatacttc tccatgcact aaaaacagtg tagttggagg 2413861 gattgctgaa tggcaaataa acacactgcc ggaagagaac aattaggaga atttgcgcca 2413921 aagtttgctg aacttcatga tgatgttcta ttcggtgaca tttgggcaag agaagaagaa 2413981 ctttcatccc gggatcgcag catgattaca gtttctgcat taattactga ctgtttctca 2414041 gcttataaat caggttcatt ttaaatggtt tttttaaaaa acccttgcct taaagcagac 2414101 tttaaggttt atcgttatgt tgaagacacc ataaaacata aataagtgca tgtttttatt 2414161 tacaacactt atgatgaaga aaggataggt tcgtatgtgt aatcaacatc aaacccgtgt 2414221 attaagcgtg tcacatgcaa aagccaaatt tgaacaaacg acgattgagc gaagaggatt 2414281 acggccgcac gatgtcttaa tcgatattaa attcagcggc atttgccatt cagacattca 2414341 tagcgctttt gatgaatggg gcggtggcat cttcccaatg gtgcctggac atgaaatagc 2414401 cggtgttgta acagccgttg gaacaaaagt caccaagttg gctgtcgggg accgcgttgg 2414461 tgtcggctgt tttgttgact cttgcggaga atgcgaatac tgtctcaacg cagaggaaca 2414521 attctgcacg aagggtgttg ttcaaacgta taactcagta gactacgacg gaaaccccac 2414581 ttatggcggg tacagccaaa aaatcgttgt cactgacaga tttgttgttc gcataccaga 2414641 tcgtttggaa atggatgttg ccagtccgct gttgtgtgca ggtatcacaa cgtattcccc 2414701 gctgaaacac tggaatgttg gccctggtaa aaaggttgcg attgtaggcg taggtggcct 2414761 tggacatttg gcaattcaat ttgcacatgc gatgggtgca gaagtaaccg tcctgagccg 2414821 ttccatgaat aagaaagagg aagctctgga actcggtgca aatcattact ttgcaacaag 2414881 tgacccagcc acattcactg cattggccgg gcgttttgac gtgatcttaa atacggtatc 2414941 ggcaaatctc gatgtagatg cctatttatc aatgcttcgt atagacggga cacttgtaag 2415001 cgttggagct cctgccaagc cggacacata cagtgtgttt tccctaatca tggggcgccg 2415061 cagcattgca ggttctctag tcggcggaat tcaagaaact caagagatgc tggatttcgc 2415121 agctgagcat ggcatcgaac ctaaaatcga agtcatcgga gctgaccaag tggacgaggc 2415181 atacgaacgt atcctccgaa gcgatgtccg ttatcgattt gtgattgata tttccacatt 2415241 gtaataggtt agtccttata tgggctgccg cttttattga aactcacgaa aaatgatctc 2415301 tttaagcaaa tattttgaag gccggtcaat cttcctgtta ttctatgaat agagagttat 2415361 taggagggtt ttttatgagc aaaaaaattg cagttcttgt tacagaccaa ttcgaagaca 2415421 tcgaatatac aagtccggta aaagcatacg aagaagctgg ctacagtgtt gtggctatcg 2415481 atttggaagc cggcaaagaa gttaccggta agcatggcga gaaagtaaag attgacaaag 2415541 ccatctctga tgtggatgca agtgactttg atgcactttt aattcctggg ggattctctc 2415601 cggatttgct tcgtgcagat gaccgtccgg gtgaattcgc aaaagcattt gtcgaaaaca 2415661 aaaaacctgt tttcgcaatt tgccacggcc cgcaagtact gattgatacg gatcttctaa 2415721 aaggcaaaga tatcacaggc taccgcagca tccgcaaaga tttaatcaat gccggtgcaa 2415781 actacaaaga tgcagaagta gtcgtcagcc acaacattgt cacaagcaga acacctgatg 2415841 atttggaagc atttaaccgc gaatctttaa acttgttaaa ataacaagaa ggcacagact 2415901 gttcgggtct gtgccttttt taaaattaag actccttcgt tacattctga aagacagcag 2415961 tcgcgtccca cacattcaag ccaaattggc cttctgaaaa tacggaatca tgtgcatcaa 2416021 tcacaagacg atcatctaaa tagattttaa agcgatcgcc ctcggcctct gttttcagat 2416081 gatacttttt attaacgtct atcggtgttt tgtattcagc aatgacagaa gcagcaccgt 2416141 tctcaaattt aaagaatttc actaggtcat gcttcgcatc cacattggca aggtaaccgt 2416201 ttttggcatc tttgtcagag cgaaacatta gtgctcctgc ccctcttccg tttccatcct 2416261 taatggtgat atcagattca taagtgaagt ctgacccgga tgctgaagac aagataaagg 2416321 aatcgccgtc cgacctccct tgtttcccct caattgtgtc tgcccacgtg ccatttacag 2416381 tcgtccagcc agtcatattg gacataaaag gtgtcgttcc ccataccttt tttaaagggt 2416441 gtatcgttaa agattttacc tttacaccgc catttgcagc atataattca agccctttgc 2416501 ttgatcggtc tgggagaata atatccgtta tgacctgctt tccgtcattc ccaaatactt 2416561 caaccgagga gcggtcaaca aaaatgcgca acttaacctt cccatttacc ggcttcaacg 2416621 gggctgtttc ttttccggtg ttaaaggccg gattaaaggt gtcgttgcct gactcgctcc 2416681 ggtcaacgaa caatttggcg ttccttcggt catagccgac cttcgtaaat tgattttcac 2416741 ctgttcggac cttaaaacca aattcagcag ctgaaccagg gcttacttta aattctgcat 2416801 ttatttcata ggcatctcca gattgccccg ctaacacatt atgacttgca ggcgatatgg 2416861 tcagattctt ccacttctta gaggttccgc gaatggtttc cagctctttc accggtgttt 2416921 ggaccactct aaccccttcg gtaaacgctt tcaattttaa ctctcttgga atggacgttg 2416981 cacttctcca tggggatgtc ggaacatcat tcgcatattg ccaattgctc atccacccta 2417041 accatagccg gcggctgtct gtggatggaa tatcagacca ggatacagcc gcataaaagt 2417101 ctctgccgta atccgtccag agaactttgt ttggcgggtt ttcattttta aaatgagttc 2417161 catcaaagtc ccctacaaaa tattgcatgc ctgatcctcc cgagaccgct ccgtttccga 2417221 cactgacctg catgacccat ttcttttgat tcggattgcc gtctaccgga agctcaaata 2417281 aatccgggca ttcccatact cccccgtggc ttccttgatc ctgtccaaat tcacttgcat 2417341 acgtccactg cttcagattt tttgatgtat aaatgaggat tcggtcaccg gccgcaagca 2417401 ccatcaccca ctttttttct ttctcatacc aaaagacttt tggatcgcga aaatcttttt 2417461 tacccgggtt tggaatgaca gggttgccag cgtacttcgt ccatgttctt cctttgtcgt 2417521 tgctataggc aatactttgc acttgatggc cttcccgatc ctgtgtataa atggccacaa 2417581 gcggcttctc tttgcctgtt tgaaaaccgc ttgtgttatt tttatctaca actgcgcttc 2417641 cagaaaagat cgtgcctttt tcatccggat acagcgcaac aggaaggtgt tcccatgtaa 2417701 ccaaatcttt gctgacggca tgcccccaat gcatgggccc ccactgaagc ccgtatggat 2417761 ggtattgata gaacaagtga tattccccag cataatatac cattccgttt gggtcattca 2417821 tccagtttgc ctccggtgtg aagtgatatt gaggacggta atcctcatca tagtagcttg 2417881 aatcggctgc atctgccgaa aatgccatag tcaacagcag ggtgaacatg atcatgactt 2417941 gaatcagtct ctttttcatt tgttccttcg ctcctctctt catgtttgaa cactttcaaa 2418001 agagactgct gcgcaagctg gtccgtttct ggcaattctc ctctgtttca ctgttatccg 2418061 aatgatttat atatgaaaag actgctgcag tttctctctc tttccttcac acaccttatg 2418121 ctaagaatcc agcccaatac ccgagaatcc cgatgacaaa gatgccgcaa ataatgagaa 2418181 gtggattcac ccctttgcga agcatccatg ccaccaataa cgttaatccg agaggcagcg 2418241 cccccggcat aatgctatct agcacgtttt gtaccgtttg aacatctact tttccgcttt 2418301 catccttaat cctggataca acgattggaa tgttgatggt ggtccatttg gacacgagag 2418361 cccccataac aaataacccg agaatcgaag cgccctctgt aagcttttga atgcgattcc 2418421 ccgctaaatc ctgaagaatc tccattcctt tcacatagcc atactttaat ccgtaatatt 2418481 ttgtgcttaa tcttatggca ttcagcaaga aaaagaatag caaaggaccg gcaatgtttc 2418541 ctcctaaagc aagggaggct cctagcgcag ctaagacagg acgaatcgtt ccccaaaaaa 2418601 ttggatcgcc tacgcccgct attggtccca tcaaaccgat tttcattccg cttatcgctt 2418661 ttccgtcaat tcctttattg ttcgccattt cttcttccat ggctgccgtc acgccaaata 2418721 taggcgctgt cagccacgga tgtgtattaa accattccaa atgccgctgt aaggcttcgt 2418781 ttcttttcgc tccgggaccg tacaattttt tgatcgccgg tatcatgaca taacaatatc 2418841 ccattgcctg cacacgttcg aagttaaagg aaccgagtaa aaaatttgaa cgaataaaca 2418901 tgctgaaaat ttctttcttc gttaatcgtt tttctttctc cattttttct tccccctcat 2418961 cgtttaggca tcaagatcat catcatcgtc atcataaaca gcaacactgc cactgtctga 2419021 tgcggccgcg actgctccgt gagcgctttg tttttgcatc acctgctggt ataaaagcgc 2419081 cagacagaga ccaagggctc caaatcccac taagttaaaa tcggtaaacg ccgctaataa 2419141 gaaaccaata tagaaaaatg gctttaaata aggaatattc atcatattga tcaccatggc 2419201 atacccgaca accacaataa tgcctccgcc tatttgcagt ccttttgtaa tgacatcagg 2419261 aatatttccc aggaacgcct gaacagcgct gacactaatt aaagcaacaa tcaatgtagg 2419321 aatcatgacg cgcaaagctt gaaacaccat cgcggtaata tgcataattt caattccttt 2419381 tatatttccc gcttttgcat attgatcagc gcggtggatg aaaaagacag tgatcgtccg 2419441 aacaaaaatc gtcagcgcct gacccgcagc tgctaaagca acagcgacag caatcccttc 2419501 gccaattcct tgatcagcgg taataactaa aatggttgag atgacagagg cgatcgctgt 2419561 atcaggtgcc atggcaagcc cgacgttcat ccagccgagc gccatcagct ccagtgtgcc 2419621 tccaagaata attcccgttt ttaagtcccc gagcaccaag ccaaccaacg tacaggccac 2419681 tagcggccgg tgtgtctgcc cttcatccaa tacacttgcg attccggtga ttgctgcaat 2419741 gattaacaac aaaataattt gtaatgaaga catattctca tccccttgat tattttgtta 2419801 cgttccgtaa aatctgtaca aaatcctcac tggcatctga aggcagctgc ctcaattcca 2419861 gtttcacgcc cttgtcactt aatgtttcaa atgcctttat atcttgttct gtgacactga 2419921 ctgattttgt gatttgcctg cgatgatttt caaaacgcat tcccccgacg tttacggttt 2419981 tgatcggtac acctgcttct ataagagata caatatcgga cggattttca aacaagagca 2420041 ttgccgttac cccttcgtag cgcggactat gaaatgcttt tgccatttta gaaaccgaga 2420101 cggcactcgc ctttacattt gaaggcgcaa cagaaaggat cagcgttttt ctcatttcgt 2420161 cctgagcaat atcgtcggag acaacgatga ttcggtcggc tgcatggact tttatccacc 2420221 ttgtcaggat ttggccgtga ataaagcggt catcaattct tgctaacaca atgttcatca 2420281 taattcatcc tctcttgtat cttgattggc tgtttttact ttttctaaat gttcactgca 2420341 cacttgaaag ctttgctgac tcattgcttt taagttgttc agcaaatctt tgagagccag 2420401 atgttctctc aggcttaata cctccagcag aatcggcagg tttacgccgg cagccatatc 2420461 cattctttga tcctcagcaa taaaggaagc tgccgcgtta tatggcgtcc ctccaaaaat 2420521 atcgactaaa aaaagcactt catgttcttc cgggatatcc ttgagcgcct gatgatattt 2420581 ttcttgcagc gtttgtattc cttccccttt gaaaaacggc actgcaatca ggttattttc 2420641 ttcaccgaat atcatccctg aagactcttt taatgctatg ggaaaatctc catgaccgct 2420701 gataataact gaaatcatat ctattgctcc tttcctgttt tgtacatcca tatataatgc 2420761 aaggatcgtg ccaacacagt tgtgttaagc gttttcattg ttatttcagc caatagcaat 2420821 ttgttgttga aacacttaaa acgaaaaaaa taaacctgta ttaaaatggt gttccattta 2420881 atacaggttc atatgaaaaa actgttttta aaacagctgg ccatgcactt cttcagcaaa 2420941 tatggcggct ataaataatt tttcatcatc acttatgcga agtccgagct tttcttcata 2421001 aggggctaat gttcgctctg tcacgtacac catttccttc agctgatcat tgatctcttc 2421061 ttcctctgag aaagcgatcg gattctgctt aattaccctt tcaaaggcga aagccgtgtg 2421121 cataatgact ttgatcaaaa ccgcattatt gaaaatgacc cccagctcat cctgaacggt 2421181 ttgcagccac tccaataaca tgtcgatcac atggtgggga ttcaagaaga caaggtattt 2421241 tttcaggcta tcctcgcaaa gctccctgac aataatattt gcttcgttca atccattgct 2421301 caaggagatg cttccttttg taatcgcctg ttgaatcagc ttctctccct ccccttcaat 2421361 taacacttct aaagatacat gcggagcatt gattttaggg tctttcgttc cgactgtcgc 2421421 aaggatttca tactcttttt cgatttcttt tatgctgttg gccagcttaa tcgatgatac 2421481 ggtcaatatg tgaatggggg tatcggaggc cttgtttacg atcgtggtta gaatgtcttc 2421541 cagctttttg gccgttccgc tacccgtcgt gcagatggat accaatgcct tctttttgcc 2421601 ggatgccgct ggctgacgct cccacaactc gataaaatcc ttcgtgaccg attgatagat 2421661 cgcatgcaaa tttaaattca aatagttgac ctttctgaca gcatccagca ccattgaagt 2421721 cgtaacattg ctgatcgttt taatagaaat gcctgtcttt tcctccagcc tgctttccag 2421781 cattgcaagc gaccccatat ctaccagcat taaaacacct tcaccttcat caacctgttt 2421841 cattttttct gctacgcatt caagaatgtc cgaaggtgaa acagtaagcg gcatgtcaac 2421901 tgctgcaatc ggcgtactcc ctagcagttc tgtcgcgact tcaaccattg aactcgccgt 2421961 gctgtttcca tgagctgcca cgataatacc gactcttttg ttctccttta acgatttgat 2422021 ggaatgaatt aacatcgtta agtagatgac ttctatttca ggaatagcca ctttaaaata 2422081 ttcctgaatt ttatctttaa aaatcatcgc cacccgatat tctttcacat gggtatcacg 2422141 aatttcatct gtctcctgtg tattcaaaac atcaatttgc tttcctcgct ttaaaaatgc 2422201 gtcaatatgc atactcaaga aataaataaa cttacggtca aatgtgcaat ccagctcatg 2422261 ttcagctatt tcttttaact gttttgtcat ttgaatcaca tcgtcttcaa cgaatgtcag 2422321 caggttgtct ttttgaaaag cttgatgatg aaaaaaactt ctgacatgca aatggacatc 2422381 agtcaagatg tactggttaa tatccttttt ggataaacct tctttcataa gcgttttcac 2422441 tttttcctca atcaaatgat ataagttaaa tgagaggtct tcgtcaattt ttgttgtttc 2422501 atcttctaca atcggagaga taatcgttgt aatattgaca tattcagaaa tggctttgct 2422561 tctttgcatg tttttgctgc tggacatcca ttcttgcttg atttcatcag gcagatcgcg 2422621 aacagtcagt tcaataactt catttctgtc aaggttatgc aaaaatccgt gtgcgcaaac 2422681 taactgaaca tttgatttca gctgtccgac attcccaaat ttcgcagagt gaataagcgc 2422741 attatagaca tcgatatgca cactcagatt cttcttaatt cgctctgctt ctttccctaa 2422801 taaaaacgtc gtcagatcca ctctttcatt aagcgatcgt tcttcaagcg aaggaatatg 2422861 aatggtcatt gggattcttc gcaaaaacgt tttcaatagt gcagaactcg gattttctgt 2422921 agtcgcacaa ataaacaata cgttcgatgt tcgtttatgt tcagattctc caagcctgtt 2422981 ataagaaccg ctgtcaataa aataaaacag catttcttgt ccctcgggag ggagacggtg 2423041 gatttcatcc ataaaaagaa tgcccccatt ggcctgttcg actaaacccg ccttatcctc 2423101 ggcagcacct gtaaatgaac cttttttgtg tccgaataat tgagaaagca ataattgagg 2423161 gttgttgtag tagtctgcac agttaaatgt aataaatggt gcgccggcct tcaatatgtc 2423221 agagtaaatg gcaaactggt aaattcggtt cgcaaaaagg gatttaccgg aaccagtcgg 2423281 ccctaggagg agcatatgca gaccgttcgg cggataaaag acagctgctt ttgcctggga 2423341 gatcgctttc ttcaaactcc cttttgcccc tatcataagc tctaggggat tcgtggaaat 2423401 gtgttgatga ttttgctttg aatttccgga aaacgcctga aggtctttca cttccatcat 2423461 ctctgtatcc catttcttgt tgaataattt ttctgctatc tcgactggga tgtatcttac 2423521 aggaaatgtt ttaattttga tgaccttttt ggaccggacg agattgttca attcaaagct 2423581 gacattggac cgctccattt tcagctgctc ggcaatctcc tttgctgaat tcccttgtat 2423641 ttttaaaaga tgatctaagg ttgaatcatg aaaattatgc ttgagctgat ggtatatttt 2423701 atctattctt ctcacgtcta tcatcctttg tccttattag ataagccatt aacaagaata 2423761 tttcgaaact ttatagtccg cgttgagatt tacacgttta aaaaggtctc tatagcagat 2423821 tgacaaagct ggcttttatg cgtatatgtt tacatgttga atcatttgca cctcatatta 2423881 gtatgataga tgctcagttc tggagggcca gtccccttca aaagtaataa tcagtaaaca 2423941 gtttatcatt ctcggggaat gtaatgatgt caaaataatc aatgacaaaa aatgaatctt 2424001 atagatcatg acaaattacc caaatataac cccttaagtt cgttcacaac taaaaagacg 2424061 gacactctat gtgaccgcca cagtattaca atttgcaaaa cttcgtcatt tttgcaatcc 2424121 acattggagg ttaaggaatc tgtaagctta aaaactttat ctccgatcct atcgatttga 2424181 tccccctgcc ggcctcaatc atagtgggta tgcaattata caaatcgtta ccgattaaaa 2424241 ctagcctgtc agattgtcca aatgactttc ctgttttact ctgctattca ggtagaatca 2424301 cgagtgaaaa atagagccac aagacatgta acagcactta aaatagtttt aaaatttaaa 2424361 aataaaagta tctattcttt taaatgttat aatatccgat aaaactttac tcatcttttt 2424421 attactggag gaaaataaaa ttgataggca attctagcaa agacaatttt ggccagcaac 2424481 agaaattgtc tagaggcctt aaaaacaggc atatacaatt aatggcgatt ggaggtgcaa 2424541 tcggtacagg tttattttta ggttcaggta aatccatcca ttttgcagga ccatccattt 2424601 tatttgctta cttgatcacc ggcgtatttt gctttttcat tatgcgttcg ctcggagaac 2424661 tgctcttatc aaatgcggga taccactctt ttgttgattt tgtaagggac tatttaggaa 2424721 acatggcagc atttatcact gggtggacct actggttctg ttggatttcc ctcgcgatgg 2424781 ctgatttaac ggcggtcggc atttatacgc aatattggct tcccgatgtg cctcaatggc 2424841 tgccgggtct tcttgcgctt attatcctgc tgatcatgaa ccttgccacc gttaaacttt 2424901 tcggagaatt agaattttgg tttgcattga tcaaagtcat tgccatactg gctctgatcg 2424961 taactggtat tctcctgatt gcgaaaggtt tttccgcagc ttccggccct gccagcctca 2425021 acaacctttg gagccacggc ggcatgttcc caaatggatg gcatgggttt atcctatctt 2425081 tccaaatggt cgtcttcgct ttcgtgggta ttgaacttgt tggactgaca gcaggtgaaa 2425141 cagaaaatcc ccaaaaagtg atccctaaag ccatcaatca aattcctgtc cggattttac 2425201 ttttttatgt tggcgcactt ttcgtgatta tgtgtatcta tccttggaat gtgttgaatc 2425261 caaacgaaag cccatttgtt caggtcttct ctgcagtagg catcgttgtg gctgccagtt 2425321 tgatcaattt tgttgtatta acatcagccg catcagctgc aaatagcgct ttattcagca 2425381 caagccgaat ggtctattca cttgcaaagg atcatcacgc acctggacta ttaaagaaat 2425441 taacttcttc taacgtgcca agcaatgcgc tgttcttttc atccatcgcc attctgattg 2425501 gcgttagtct gaattattta atgcccgagc aagtcttcac gctgattaca agtgtttcaa 2425561 caatatgctt catttttatt tggggcatca cggtgatttg ccatttgaaa tatcgaaaaa 2425621 caaggcagca tgaagcgaaa gcaaacaaat ttaaaatgcc tttttaccca ttatccaact 2425681 atttaacact tgcatttctc gcgttcattc ttgtcatatt ggcactggcg aatgatacac 2425741 gtattgcttt gtttgtcacc ccggtctggt ttgttttatt gattattttg tataaggtgc 2425801 aaacccgcag aggacataag gtgaaataaa aaaaagacaa gggatactca ctcccttgtc 2425861 tttttatatg tgtcaaacac taaattaaac tttggtttca aatttcattc acttcattta 2425921 agtgttaact caaaccagtt ttgatgccga aacctactaa tattattccg gtaatttttt 2425981 gaaacacttt ctggaacttc gagtttttca tccatttttt tgcgtaatca ataatataaa 2426041 caagaaacag gaaccacaac accgctaata aggttaggat tgaagctaaa atgatgagct 2426101 gctggtttat atttccgttc aaattgataa attggggcat gattgtaaca tacaccaaaa 2426161 cagttttagg attgagaatg ttactgagtg atccctgcat aaaggaagtt ttataataac 2426221 gtttcggaga acttgccata ttttttgctt gggattgcat gtcatctaac gaaaacatac 2426281 ttttagcaaa aaaacttttt acacctaaat aaattaagta tgccgctccc aaatatttga 2426341 tcgttgtgaa aagaatcact gactttgcga ttaccactga taatcctaaa atggcaatca 2426401 ccgtccaaaa ggaaagtcct gtcgccaatc cgagaatgtt ataacggccg gctttcggac 2426461 catacctaag cgtatttttc atcacaagca tcgtatctgc ccccggtatg ataaccatca 2426521 tggcagcgat cggtatgtat gcgagtaagc tgtgcattgt tctctccccc tttaaaaatc 2426581 ccctcaatca tatagtgact acaaaagtaa ctacttataa aagtgtatca atgcgtttgg 2426641 aataaatcaa tatgatttgt taaaatagcg attactaagg cagcgattgc tctttatatt 2426701 ggaggatata tgaaagaaaa tatgttagac attttaaaaa acctcaattt tacagaatat 2426761 gaatcgaaag cgtatttagc attattgcaa gaatcacctt taacaggcta tgccgttgcc 2426821 aaaaaatccg gagtgccccg ttctaaaatt tatgaagtat tggaaagtct tgtcataagg 2426881 ggagatgttt ttgtcagtca tggaaatacg cctcagtatg ttccagtccc cgcaaaagaa 2426941 ctgattaaaa accgccggct caaagcggaa gagcattttg atcaggctga gaaatatttt 2427001 gaaaagttcg agcagaccgc aaatgaccgg gaaaacatct ggaatatcac cggccgcagt 2427061 gaaattcttg aaaaggtgaa ggcttgtatc ttatctgcca aaaaaagaat cctcttagaa 2427121 atatggaaag aggattttaa ggagatagaa gcagagctca aacaggcggc agaacaaggc 2427181 gttattgtca ccattattgc gtacggagac atcgtatctg attttgccaa tgtttacctt 2427241 catgatatga gcagtgaaat tacagaagag tatgacggac ggtggcttgt ctatagcgga 2427301 gatgattcag aagtagtagc gggcattgtc tcacttggca acgacagccg tgctgcatgg 2427361 acgatgcatg tagggttagt catgcctatt actgaagtga tcattcatga tctgtacctc 2427421 atggaaattc tgaaaaagca tagagagctt ttagaagaga gcttcgggaa aaatctcatc 2427481 cagttgcgcc gtaaattttc tattcactca gatttcaaaa aacattattt ggaataatgt 2427541 ttgtcatctc ttaccccaaa aacaaggctt gtacaaaaca agccttgttt ttttatgcat 2427601 aaacccccca tgctgattta cttctctctt ttaaaaaatg tgattctgcg caaactattt 2427661 ttcagcctgc cgcgtctatc ctaggtaaca gcctacgata tacgtatatt caaaaaggag 2427721 ccctttattg caatgaagaa aaaacaaaca acaaaagcgt tgcttgtcac atgcataact 2427781 gaccataagc aagatttcta caggttggct ttcagttatg tgaaaaatca agatgacgca 2427841 ttagatattg ttcaggaatc tataaaaaaa gcgctgagct cagttgaaac ggtcaggaac 2427901 cctgagacga taaaaagctg gttttataaa attttagtac ggacagccat tgactttttg 2427961 cgcaaacaaa aaaagataag agtgatggac gacgaaacga tagaattttt aagcaaagga 2428021 aaggaagacc attacaagga tactgatctc catgaagcgc ttgacgaatt gccgtaccgc 2428081 tataaaacca ttattatttt acgttttttt gaagacctca aattagaaga aattgcggaa 2428141 attacaggag aaaacacgaa taccgtcaaa acgcgcctat acagagcatt gaagctgatg 2428201 cgcattcagt tgacgaagga ggatctttct taatggataa gagattacag caattaagag 2428261 aagaatataa aaatgttcag attcctaaag aattggatat cattgttgaa aaagcccttc 2428321 agcaagaacc aaaaaagaaa agaatcgtta tgtggccgac atcagcagca atcgctgcag 2428381 ctattttatt cactgcgctt gttaatatca acccggacgc cgctcaggct atgtcaaaga 2428441 tccctgtcat cggcaaaatc gtcaaagcga tcacctttat tgaaatcaaa gaggaaaaag 2428501 accaatcaag cattgatgtc aaaacacctg ctttgtccgg gctttctaat aaagagcttg 2428561 aaaacagcat taacgagaaa tacttgaaag aaagccagca gctgtataaa gagtttatac 2428621 agtccacatc caaaaacaaa aaagggcatc tcagcatcta cagtgattac gagacggtca 2428681 cagacacgcc agatttactc tctatccggc gcaatattga aacaacacaa gcatcttcct 2428741 acacacaaag ccgttatatt acaattgaca aaaagaatga tattttactt acattaaaaa 2428801 gcttattcaa agatgagcgc tatatcaaag tcatcagtca aaacatcaaa gaacaaatga 2428861 aacagcaaat gaaggaagat ccaaataaaa tatattggct cactgacgaa gatgcagaac 2428921 cgttcaaaac gattcttcct gatcagacgt tttacattac tgaagaccat aaacttgtga 2428981 tctcatttga cgaatatgaa gtcgcccccg gctatatggg cgttacagag tttacaattc 2429041 caaccggcgt catttcaaac ttgctcgtgg gagaacgtta tattcgataa aataaaaaca 2429101 tccatctaag attatggatg ttttctctct tctctattcg aggtcgtaac cccgctatca 2429161 aaaacaacga gaatatttgc atactattgg aggaataccc atgtatcaca agacacagca 2429221 tcatcgatac attcctggac ttgatggcct tcgggctttc gccgtcctgt cagttatcac 2429281 ttatcaccta aatttcaatt gggctaacgg tggttttatc ggggttgata tcttttttgt 2429341 tttatccgga tatttgatta catctattct attaccggca tatggaaatg atatcaatct 2429401 tgattttcgg gatttttggg tgcgccgcat tcggcggctt ctcccggcag cgtaccttat 2429461 gatcttttcc actgttgtgt gggtcgtatt gtttgatcga gaactattgc acactgtacg 2429521 tggagatgcg atctcttctc tcttttatat gagcaattgg tggtttattt ttcacaagct 2429581 atcatatttt gatagtttcg gttccccatc acctctaaaa aacctttggt cgctggcgat 2429641 tgaagaacaa ttttatatca tatggccgat gtttttagtt gttggaatgt acataatgaa 2429701 aagccgcgcc agattggctg cggtgatatc attgcttgtg ctttgttcag ccgtgatgat 2429761 gagcgtactg tatgaacctg gcggagatcc gagccgcgtt tactatggca cagacactcg 2429821 ttcgtttgaa cttctcatcg gatgtgcctt ggctttggta tggccgatga aaaggctgtc 2429881 ttccaacagg ctgccaagca aactgaagca cactttgcac gccactgaat ttttggcatt 2429941 ttgtatttta gtgttgtgtg tctatttcac agatgaatac gagccttttc tttacagagg 2430001 cggaatgcta ttcattagcg tgactgccgc aatccttatt gcatgtgttt gccatccgag 2430061 cagcttttta ggcaatctgc tttcatggag gccgcttcgg tggcttggaa cgaggtctta 2430121 cggaatttat ctttggcact accctgttat tgtgttaagc acgccagttc aagaaatcgg 2430181 aaaccctgtt ttttggcata tcgtgctaaa ggtcattgtg acatgtatac ttgccgagct 2430241 ctcctaccat tttattgaga agccgatacg gacacaggga tttaggtcat tttcccgccg 2430301 tgtttttata catagaatca aggaatggaa aacgacatct gtcatcagca aaatgtcaat 2430361 tggtttcatt attttcgcta tacttatttt tgcaggcggg ctgtcagggc tagccggcga 2430421 gcaaaagcac cctaccaaat ggacctatag ctcacaagaa acaaatgctg acaccagcca 2430481 ggcttctggg gataaaaaga acgctgcagc agataaaaaa cacaatcctg aacaaaagac 2430541 aacagattcc aatcagggtc aaaaggaaaa caaagatagt gggcaagaga ctcataaaaa 2430601 gaaagacacg caatcccaac agttgaaaaa accagcagac actgcgaaag aagttttagc 2430661 tataggagat tccgtcatgc ttgatatttc ttcacacctg cgtcagtcat tttcaaatgt 2430721 gacgattgat ggaaaggtag ggagacaaat gtctcaagct ttggaactcg caagggaata 2430781 caagtctttt aatcagccga acaaggctgt catcattgag cttggaacca atggctattt 2430841 tacaaacagc caaatcgaac aactgcttca atctttctca aaagctcata tttatcttgt 2430901 caatacacgg gttccccgcc aatgggaaag caaggtaaat gaatctttgc agcaacaggc 2430961 ccacgcacat caaaatgtta cgttagttga ctggcataca gaagctcttc agcatccgga 2431021 atattttacc cctgatggtg ttcacttggt tcctaaaggg gcaaaaactt tgactgctct 2431081 tattgttcag gcgatgaaat cgtaaaaaag agatcctata cagatcactt ttttacttta 2431141 gtttctgatc gttgattatg tcttctttca gcaaggcagc ccttatgttt acatgccgtt 2431201 tacgtaaggg taagccaaaa ttgaatggag ggatgataat gaaaggaaat gaagaacatg 2431261 acatccaaaa agagttgaaa cgatatgagc tttttttcaa aaaacgatat aaggttcttt 2431321 atacagtaaa cgattttatc atcggtgcta tgtttctcgt tggaagtttt ttcttttttt 2431381 atgaccggtt aatgtcggca gggatatggc tgtttgcgat cggaagtttg ctgctgttaa 2431441 tcaggccgac cattcggctg attcatgact ttcattaccg taagcatgtg gaacagcaat 2431501 tcaagcatca atcttcaaca gatgactgat cttaaggaat aagaaagaac aaaatgccaa 2431561 aagcctgagt cgaaaatcaa aaacaagact ttcagactat ttatttttaa aaacaaggta 2431621 aaaagaacta aacttttgcc tctgcatgcc gatatgaata ataaggccgg cgcgatactc 2431681 cctataacat ccttttcagt agatttcatt atcgtgccgg ttttctcata tgcaaagcaa 2431741 tcccgccaat cagattggcg ggattttata ttttacattc ctgtccaaac gtctttcaca 2431801 taacgtcttt gatcttgcag cttttgcagc catacagctg attcttcctg acttgctgct 2431861 ttttcagctt catatgccaa tcgcaaagtt ctctctacat caggagccat ttgcgatcca 2431921 tcaccgcata cgtaaatatg agcccctttt tcaatgagtg tcatcaattt ctgcgtatct 2431981 tgcttgagca agtgctggac atatcctttt ggttcgtttt cgacgcgcga gtagcatcgg 2432041 cggattgtga ccaaaccgtc ctgttccgct tgatccagct cttctctgta aaggtcgtca 2432101 tggtccgggc ggcggcagcc gaagtataaa agtgcttcac caagggtgct tccttccttc 2432161 ttcaaaaccg atcttgcctg aataaagcct ctgaatggcg caattcctgt gcccggcccg 2432221 accataatca taggcgtttc aggatcattc ggcatctgaa atccggactg cggcgtacga 2432281 atgaagcaag ctgctgcatc acctgtattc aattctgcta aataattaga ggcgacaccc 2432341 cggtattcac ctcggccgct ccatgctgag gctttcacaa ctcctaccgt catgctcacg 2432401 atatttgcat gaactttcgg tgagcttgaa atggaatagt atctcggttt tagtgatggc 2432461 aaaagtgcta aaaaccgttc aaacggcatt tcgcaagcag gataatcctc taaaaaatca 2432521 agcatggtaa gacgttttgc aagtacctgc tctttgtaaa tgccatcatc tgaaacgagc 2432581 tgttccagct ctttttgatg cggcggacaa actgtataag aggccagctc ccgaagctga 2432641 agccttgatg ccggttcctg cagctctaca taggacgaca ataaatccac tactttgatt 2432701 ggccgatcca tcggcagatg agccatatga gcgcttccgc ttacttttat cacatgattg 2432761 gactgcaaac cgaatcggct gagaacccgc tgaacaagct ccctgctgtt ctttggcagg 2432821 attccgatat gatcgccttc tttatatgtt ttaccagccg gaatttccaa ttcaatatgg 2432881 cgggttgaac gcgtgctggc agctgtctgg agttctcgat tctctaacac aatcccttca 2432941 aacgcgccat atgctttagc aaccggcgtt tccgtcgctt cactgagaaa agtaatcgat 2433001 aatgaaggcc tgtcttcttt ctgggctatt tcgttaatat caaatgcgtc catcgtttcc 2433061 ttccagaagc ggttttccca agactcgcgg tggctttcaa aatcatcggc ggcgtcacct 2433121 tccccaatcg ctgttaaacg cgatgccccc tttgctttca tcatgtcatc aatcaggcgg 2433181 ggaatccgct gatacgtgct ggcccagctc cggtttccgc agccgaatac cgcataggaa 2433241 acacctttca attggccttc ctcaagctct ttcagccact ctacaaatcc ggcagcatta 2433301 tcaggcggcg ccccattata agaagccgtt acaatgacga ctgccccttc ttcagggagc 2433361 ttgccgatat aatcatcaag cggagccgtt tcagctgtaa agcccatctg gcggccttga 2433421 gcagccagtt caccggctat tccctcagct gtcccaagat ttgaaccaaa aagaacaagt 2433481 aaaggtgtgc cgtgtttagg tttggtttct tttggctttg tttctgcttt gatgtctgcc 2433541 tgttcttttc tctgtacatt gattgccgct gtttttcgcg gtttcacagt aattttaaaa 2433601 tcatccggct tgatcgttaa tgcttctttg atttttagtt cgtagccagt atggtttatc 2433661 aattcaaaat gctttaatac aagaccgaga accattgtcg cttcttgaag agcaaactgc 2433721 atgccaatac aagcgcgctg tccgtttcca aacggcttat acgcatggtg agggatactt 2433781 gaaggatcct caaaccgttc cggacggaaa tcttccgcat ccggtcccca agcgttttga 2433841 tcccggtgca gttttggaat taaaacagtg actggctgcc ctttgctgat cggatattcc 2433901 ccgcctagaa cagtatcctc cttcgcatat agagaaaaag ccggagctgt tggatacagt 2433961 ctgagggttt catttaaaac catccgaatg tatttgagct gctggatttg tttatattca 2434021 ggcgtgtcat ccgttaacac gcgatccgct tcctcctgag cttttttcag tttttccgga 2434081 tgtgtaagca gacaataaat cgcaaaggat agcaacccgc ttgttgtctc atgtccagca 2434141 attaaaaatg tgatgatttg gtatcgaatg ttttcgtcat ccagcgtttc acccgttact 2434201 ggatctttgg cataaagcat gagagacaag agatccttaa tgttttcatc cggattcgcc 2434261 tttcgctccg ctatcattct atcaaccagg gagttcatga cttctatatc cttttggaac 2434321 tgcagcttcg ttttcaccat cattttatct tgcaggccca gtcttttcga ttgattcatc 2434381 gcctctttta aggcacggag catactggtg ataaacggat gctgtgaatc acggtaaaag 2434441 ctgttgaatc gatagttaaa cccgcataac ccaatcgtat caagcgtcag acgtgtcata 2434501 tcgtccgcta catcaatttc ttcattaggg tttaaccggc tccacttttg aatcagctgg 2434561 gttgcgatat ccagcatcat agaatgatag cctttcatcg ctttttgact aaaactcggc 2434621 agcaaaatgc ggtgggcttt ttgccagttc ggttcgtgcg tccagcttgt aaataagcca 2434681 tctcccccga actcacgcac cttttgcaag cctttgccaa ggttcttgtc aaagcgtttt 2434741 tcatcacaca cttcagccac aagattgtgg ccggacacaa aaacactgga tactcccgga 2434801 aaatcaaaac ggaaaatcgg tcccaattca tcagctatcc gccataagga ttgagaaagc 2434861 tgttcttttt ccagatgcgg aagatttttt aaaggtccgt atgttttggg ctgaggtatt 2434921 gcgcttgcct gtttcattaa catctccctt tcctattttt gtgatgaatg aagcttaatg 2434981 gcgtcccagc agcattgttc caattcagta attaaatcag tgtccatctc tatatcacct 2435041 gtttgaacga gctgatatat cttgagaaac gcccctaata caatcgcaat taacacatta 2435101 gagggcaggc tgcgaatcac gccttccgct tttcccttat taaaatagtc atcaagcatt 2435161 tgagtcagat tttctatcat ttttttgctt gtatgattta agtaatgagc gtcttttttg 2435221 gtttcaagaa aaaaaagcgc atagtcgctc tctttcgtaa actgaacgag acagcaaaat 2435281 acgtggtgaa agccttctct gacaggcaat tctgaaacgt cttgcttcag tttttccgta 2435341 aatcgctgga tgctttcttg aaacagtacg ttaacgagtg tttctttgct gtcaaaataa 2435401 cgatagatcg ttcctgtccc tacatgagca cgttcagcta tcataggaat agtggtagcg 2435461 tcaaaacccc tttccgtaaa aagtgagact gacgctttca taatcatgtc gtatttactg 2435521 ctggatgcgg atatcatgta atctgacaac ctccgattcg tttacggaat gaatattcat 2435581 tccttttgtt cacaaagaat gtctgccctg tctgatatca cctctttgtt ctttcttctg 2435641 ttataagttt atatgaaaaa aacttttttt aatataaagt atatgcaaaa aataaaaaat 2435701 taagaaaata tacccaaatc ctaatacgag gatcttggat atatttcccg agaaattttt 2435761 tatttaacag ccacaataca tagacaggaa gcacgcctga taacagaaag atccctgaaa 2435821 tgctggtctt tcagcagttg aatatacgtt ttctcttttt caccggtatt tgtgtcaata 2435881 ctgatataaa accggccgtc aatttgaagc accctgtaaa tttctcttaa tgcaagccta 2435941 atatcggtgc agctttgaac cgtatgtaaa gaaaagactt tattaaaggt acggtcatca 2436001 aagggaatgt cctctggata gccatgaaaa acctccccgt tccccatgtt ctttcgattc 2436061 gcacgtgata tctgtcttac ctttcgtttt gaaggatcaa tgctttttag gctacccttt 2436121 tttagtttct tggttatgct tttaaagaca gtgccgtttc caattccaat ttctaaaatt 2436181 ctgtcatttt cttgtatatc tatagagtca atcatcatat gctcaattgt tttggttagc 2436241 ttatatttcc gagaaaataa tttccaaaaa tccgatcgtt tatagagtct attttctagc 2436301 attttaaaca cctgcttttg gtttcctatg tttatttatt atcttaaaaa aataaacatc 2436361 atcttcattt ctaaaagtga aggaaggtac caactagacg gcaatgtatt gaaaaatgtt 2436421 tcaatagaac taaacttttt catttttttc cgaaaaaaaa gcagaaaaca taatgttttc 2436481 tgccctcttt ctaatgccaa tgataaggga atacatacag cctttgctgc tgcattgcca 2436541 tcagcctctg ctgtcggaat ggatttccat aaccatgttt gaaggaatgc ggcatggacg 2436601 cataaccatg gccaatcgac ggcagtcttt tttgataatc gttcatcatg ccatcacctg 2436661 cctcacaata acgttgattt actatatgca ggcgcgcatt ttcttgacag ctatttcgct 2436721 aaacttggtc cttctccatt gtataatgca tcaatagttc cattctaagc atatgccatt 2436781 cccccttcag tttttttcgt tgcttttagc gccagtttgt taaataaaga tgctttaact 2436841 gagactcttt catttcatca taaatttgtt caatctgctg ttctcgttcg aattcttcca 2436901 ggcttttaaa ccgtttttta atcgttaacg ttaaaaagaa taggttaatc gtcatatcgc 2436961 tcaccccctt tcaaagtccg catcaagcga aataacccgc ggcacaaccc ttctgccgcg 2437021 ggcaaataaa aaccgcagac aaaagaagac accaatgcct ctactgcctg cggggagttg 2437081 cgtatgtccg actattccga atttaatgcg tgcgataagc atcggttaag gaaggacacg 2437141 aactcttcca caggctgaat aaaccatgaa cttttacatg tgtatcacgt acaggttgac 2437201 gtcgttgtct cattgtcatt ttggttcagc ctcctttgct tttttcttac tttgtaagta 2437261 tatccaccaa attccatttt gtaaacatct ttttctaaaa atggacggaa attgtgcaaa 2437321 tcatcgaatg gatttgcccg ttggtcatga cacctgcttc atttcttttc tggagcggtc 2437381 tttcttatga tatgcaataa aataaatgag accgacaaat acagctccgc cgatgacatt 2437441 accgataaaa gccggaatga tgtttccgat gaactgcccc cacgtgaatg agcctgcaaa 2437501 aatggcagca ggaatcacaa acatgttggc gacaacgtgc tgaaatccga tagccacaaa 2437561 agccatgatt gggaaccaga tgccaaggat ttttcctgct gcgtcttggg cgccgaaaga 2437621 aagccacact gcaagacata caagccagtt acagccgatg gcggaaatga gaaccttgcc 2437681 aaagctcata tcaagctttc cttgggcaac ggcaatcgtt ttttctaaat aaggacctgt 2437741 ttcagtcaat ccaaccaaat gcccgaaaaa gtaagcaaca aacaatgcgc cgattaagtt 2437801 cataattgtg acgattcccc agttaatcgc taactctttt actgatattt ttctcgaaaa 2437861 taacgccatc gcaactgaca tcatattgcc tgtgatcagt tcagcgccag cgagaacgac 2437921 aaggatcagg ccgactggaa atactgctgc accaatcaaa ctggacaggc tcccccattc 2437981 tttcggaaga tcgccaatta ccctgatatc aagcaaatac ccaagcgcga taaatgcacc 2438041 gcctaaaaac cccagcacaa gcagtgacgg cagcgggagc tttatttttt tcatccctgc 2438101 ttcaattgct gcttccgcta tttcatccgg ttttcgaaaa gccataataa aacgcctcca 2438161 ttacttcttc ttttctcaca gttatgcaag aaaggcaata aaaaaggcag cactcaaata 2438221 acctgtgtca aaccaggcgt ttgaatgctg cctaacttgt atgcataccc atacaacaat 2438281 atcaagcagt atataagata ttgaaagaga atatatacag ttcgtgcata cattccattg 2438341 ctttagcctt ctataactgt agcaacatca tatcaaatgt gacaaatttg tgtcaatgac 2438401 aaatatacta gctttgcaga gcttcttttt gctcatctat ttttcggtca aaaacaaata 2438461 cagatacagc gatgttttcc tcaattttaa tatcagaaaa caaatggact agcttagctc 2438521 ccataagttc ctccattcct tccggtgttt gtttggaata aaggtcttga attaggcttg 2438581 tccgggccgc atgtaccatc tctcttcctt caggcgtgcg ggcaataaac tgctcgcttg 2438641 cactcagatt tccgtatagt gttgaaactg ccatgttttc tacaaataca gtatgaattc 2438701 tctcaggccc ttttccgaac aattctttgc gaagttttcg aataatatca ttgaattcat 2438761 gaattttttt agacatgctg attacccctt ccgatattgc cttataaagg cttttcccgg 2438821 ttcccctcag gacatttcac ttggttaaaa ttttcctgcc atattgtatt ataataaata 2438881 tcacattata ataaaagcag tgttgatgga tttgtaatag gatcttgtta tgagtctatc 2438941 gttttataaa aatcaaggat tggtctgtta gtaagacttg ctagtgaact attccgccat 2439001 gtgtgtttac accttcttag aattaagggc aggtgtatct atacatggct ttttttgact 2439061 tcttgaaaga aagatggagg ggaatatgaa tatgatggac gttaagtcga tcagtgtccg 2439121 tgtagacgga acagaaattc aagcacgagc aggggccaca attttagata ttttaaatga 2439181 aaacggaatt gagtacccgc agatttgcca cgtaccagag gttgacccga ttcaaacttg 2439241 tgatacttgc atagtagagg caaacggcaa gctggttcgt tcatgcgcga cggttgcaga 2439301 aaacgggatg tctattgatc tttcaggaaa tcgagtgaaa gaagcgcaaa ccgaagcgat 2439361 ggaccgcctt cttgaaaatc atttgctgta ttgtacagtt tgcgataaca acaatggaaa 2439421 ctgtacgctg cataatacag cggaaatgat ggggatcgag catcaaaaat acccatacac 2439481 gccaaaagaa gatccttctt gcgcggttga tatgtctcat cctttttacc gctatgatcc 2439541 aaaccaatgt attgcctgcg gccagtgtgt tgaggtctgt caaaaccttc aggtaaatga 2439601 aacactctca atcgactggg aacgcgaacg ccctcgcgtc atttgggatg agggagttcc 2439661 gatcaatgaa tcttcctgtg tcagctgcgg tcagtgtgta acagtatgtc catgtaatgc 2439721 actgatggaa aaatcaatgc tcgggcaggc tggttttatg acaggcatta aagaggacgt 2439781 catggaaccg atgattgatc tcgtgaaaaa tgttgaaccg gggtatggca gcatttttgc 2439841 catttctgaa gtcgaagcgg caatgcgtga aacgagaacg aaaaaaacga aaactgtatg 2439901 tacgttctgc ggtgtcggat gttcatttga agtatggaca aaaggacggg atattttaaa 2439961 gatccagcct gtttctgatg ctccggttaa cgcaatttcc acatgtgtca aagggaaatt 2440021 cggctgggat tttgtcaatt caaaagagcg gatcacaaag cctttaatcc gtaaaaacgg 2440081 agcctttgtg gaatcttctt gggaagaagc cctcgatctt gtcgcaagca gattaggatc 2440141 aattaaagag cagtacggta aaggctctgt agggtttatt tcttcttcta aaattacgaa 2440201 tgaagaaaac tacgtcattc aaaaactagc gcgtcaggta tttgaaacaa acaacgtcga 2440261 taactgctca cgctactgcc agtctcctgc tacagacgga ttgttccgca ctgtcggcat 2440321 gggcggtgac gccggcacga ttaaagatat tgccaaagca ggcctggtca tcattgtcgg 2440381 tgccaatccg gcggaaggac acccagtgct cgcaacacgc gtcaaacggg cacacaagct 2440441 ccacggtcaa aaactgattg ttgctgacct gcgtaaaaat gagatggctg agcgatctga 2440501 tctgttcatc agccctaaac aaggcacaga ccaagtttgg ctgatggctg ttacgaaata 2440561 tatgatcgac caaggctggc acgatcaggc gtttattgat gagaacgtca attactttga 2440621 agattataaa gaaaccctta aaacgtatac gcttgattat gcagaacgca tcacaggcct 2440681 ttcaaaagaa aacatcattc aaattgctga aatgattcgt gatgctgacg gcacttgtgt 2440741 cctttgggga atgggtgtca cacaaaatac aggcggttct gatacatcag cagccatttc 2440801 aaacctgctt ctcgctacgg gcaactatcg ccgtccaggt gccggcgctt atcctctgcg 2440861 cggacacaat aacgtgcaag gcgcatgtga tatgggaaca ttgcctggct ggctgccggg 2440921 atatcagcat attacagatg acaaagcacg cgctaaattt gaagaggcat atggtgtcga 2440981 gattgatgga aagcctggtt tagataatat tcaaatgctt catgccattg aagaaggaaa 2441041 aatgaaagct atgtatcttg tcggtgagga tatggcactg gtcgattcaa acgcgaacca 2441101 tgtgcatgat attttatcaa gccttgattt cttcgtggta caggacatct tcctgtcaag 2441161 aacagctcaa tatgctgatg tcgtcttgcc ggccactcct tcacttgaaa aagacggaac 2441221 atttaccaac acagaacgcc gtgtccagcg attgtatcag gcgcttccga cgcttggtga 2441281 cgcaaaaccg gactggtgga ttattcaaga ggtggcaaac cgtttaggag cgaattggaa 2441341 ttacagccat ccaagtgaca ttttctctga aatggcgagt ctttctcctc tgtttgccaa 2441401 agcaagctat gaggtgcttg aaggctggaa cagcttccta tggggcagct tcacaggtga 2441461 aagcacaccg cttctgtatg aagacggatt taatttccct gacaaaaaag cccgctttgc 2441521 cctttctgat tggaccgagc cagcggcatt tccggaggaa tatgaccttc atatcaataa 2441581 cggccggatg ctggagcatt tccacgaagg aaacatgaca aataaatcga aaggcatcca 2441641 agcgaaagtg ccgaatgtat tcgttgagat ctcacctgag cttgcacaag agcgaggtgt 2441701 ttgtgacggt tcgcttgtac ggctcgtttc tccgttcgga gcagtcaaat tgaacgcgct 2441761 gatcacagac cgggtacgga aaaatgaact ctatttgcca atgaactcga cagacaagga 2441821 gtcagcgatt aacttcttga cgggccctgc agctgataaa cggacgaaca cgcctgctta 2441881 taaacagaca aaggtccgca tggaagtgct tggcggctgt gaaacagcgc cgcttccaaa 2441941 aacaaatccg cgcaacaaaa aacggcatcc gcaaaacgga gtcgaagcag aaagaaaatg 2442001 gaaccgccct ggctatgtac atctgactga ttaaacgata ggaggaaaac gaatggccac 2442061 tccgattacg acgatcaaaa aagaaacaaa aacagctgag caaattaagc ttgaaaaaat 2442121 agaagaactg aaagagctgc tggcggaaaa tgaggacgcc gtctctaaaa cgatgacgtt 2442181 aatgaatgaa ctcaatgatc ttggaatttt tgatgcggca acaagcatgc tcagagcgaa 2442241 ggaagacatt gccaagattg cgcttggcca agtttcccgc gagcctgtca ccaacctcat 2442301 caacacgatg atggccgccg gaggcgcatt gacaaaagcc gatcctgagt ttacagcaaa 2442361 gcttttagaa agcgtaatgg ctgggactga acaggcacaa agctttttaa aagaagacaa 2442421 gaaagtcggg attctcgacc tgttaaaagc aatgaacgat cctgacatca acagagccgt 2442481 cgggttcggc cttcagtttt taaaaggcat gggaaaagaa cttcgagaac aataacagaa 2442541 aaacagccat ctctgatgat ggctgttttt ttattcgtcg gcttcttcca gacgcttctt 2442601 gtaaataagt gaacggtcag cgcaaaagaa ggcaccggct aaaaatacgc aatccgctaa 2442661 aaacatcgtc gatttctggc ctaatgttaa gccttgatca gggagaactg cgcctatata 2442721 taaaaaagtg ctgactgcaa gcaatgtaaa agcaaaatgc ttgtagtctt cttttaaaga 2442781 tttcattcta tttttgttca aaagaatcac ctgccagatt catagtatac gactattata 2442841 atataatccg gcggcttaca gagaaagtaa ttctatccat ttgttatata ttttcaagcg 2442901 cttggccgat atcttccaac aagtcttccg catcttcaat tcctacagaa attctgatca 2442961 agccgtccgt aatgccgagc tcaagccggc gttctctcgg aatagaggca tgtgtcattc 2443021 ttgcaggaac agaaattaag ctttcaaccg cccccaggct ttcagcaatg gtaaacagtt 2443081 tcagatttcc taaaaacgca tcaacccgtt cttcactgcc aatatcaaag gagatcatgc 2443141 cgccgaagcc cgctccttgc gtttttgcaa gctcatgtcc gggatgattt gaagaaccag 2443201 ggtaatataa cgtttggaca gcagggtgat tctcaagaaa gcttgcgatt ttccgcgcat 2443261 tttgatcgat cgcttccatt ctgagtccca acgttttgat tcctctcatt aacagccagg 2443321 aatcttgagg gccgagcacg ccgcctgtgg agttttgcac aaaatgcagc tcttctccaa 2443381 gctctttcga agctgtcaca actaaacctc cgacgacatc actgtgtccg ccaagatatt 2443441 ttgtcgcact gtgcagtacg atatcagcgc ctaaagtaag cggctgttga aaataaggag 2443501 tattaaaggt attgtctacg ataagcagaa cacccgcttt ttttgcgata tcagccatga 2443561 gcgtcaggtc ggtgattttg agcaacgggt ttgtcggtgt ttcaatataa attgcttttg 2443621 tattagggcg aatcgctttt tcaacttctt ccctgctgct cgtatcaaca aatgttgatt 2443681 caatgccaag acggttaagc acctttgtca tcacgcgata tgttccgccg tacacatcat 2443741 cagtcaacac gacatgatct ccgctgttaa acagcatcat aaccgctgta atggcagcca 2443801 ttcctgagct gaacgcatag cctgcttccc cgctttccag ttctgtcaca agtgcttcga 2443861 gagcggttcg agtcggattg gccgttcttg aatactcgta gcctgtatgc tgccctgctt 2443921 tcggctgctt gtacgtgctt acttgataaa tcggcacgga aactgcgcct gttttctcat 2443981 cacctgtgat tccgccatgt atcatcaatg tttttttctt catatcagat gcctccttcg 2444041 tatatttgtt tgctgatata tcgatcgctg ctgtcaggaa atactgtgac aatgttagtt 2444101 ccagcggatg cttttttcgc ttcctccaat gccgcataaa gcgctgcacc tgaagagctt 2444161 ccgatcagca ggccttcttt ttctgccgct tctttcacaa gtctaaacgc attctcatct 2444221 gttacggtgt agatctcgtc aaaatggctc ttatccatat aatcggggat aaactccatg 2444281 ccgatgccct ctgttttatg agcgtggggc tctcctccgt ttaaaatcga gcccaccggt 2444341 tcaacaatca ccgttttgac tgctggattt ttttctttta agaaggaagc tgtccctgcg 2444401 aatgtgcctc ctgatcctgc ccctgcgaca aatgtatgaa tattcccgtc aagcgcttcc 2444461 cacatttcag gtccaagcgt cttatagtaa gtcgatggat ttactcggtt tttaaattgc 2444521 aaaacgcaat aagaattttc aatttcagtc tccagctgaa tggctttttg aatggctccc 2444581 tgcattccgt cttgacgcgg tgtatgaatg attgatgcgc caagcgcttg cataatttgc 2444641 tgtttctctc tgctgaaatg ttcagggaca cagaaaatcg ctttcagccc atattttctg 2444701 gcacttaacg caaggccgat ccctgtattg cctgccgtag cttctataat cactccgccg 2444761 ggtttcactt tgcctgaatc gagcgcgtca cgaatcagca tatctcccag tctgtctttg 2444821 atgcttcccc ctggattcat catttcaagc ttggcataca ccgcgactcc ttctggaaca 2444881 tcaaagttct tcaagcggag aagcggtgta ttcccaatca gctcggtaat gtccgtaatc 2444941 actgtcatat atgtcctcct ccttaataga ggttgttttt agagaaaaac ggaggagaac 2445001 gttctccccg ttttaatgaa ttcgtttgat cacctttaac acaagctctg ttgaatgaac 2445061 agccgcctgc tctaaaaatt ggtcaaatga aacatgtgat tctttgcctg cgatatctga 2445121 taacgctctg atgacgacaa acggcgtttt aaattgatgg catacttgag ccactgccgc 2445181 agcctccatt tcaaccgcgt acagatcaga aaatctcgca cgcacctctt caacccgctt 2445241 cggatcgttc atgaaagaat cgcctgttgc aatcgttcct tttgcaacct gaatgccgtc 2445301 gagttcagat accgcttctt cagtgatgct gatcagcttt tcatccgccg cataagcagc 2445361 cggaagaccc ggcacttggc cgtattcata gtcaaaagcc gttacgtcta catcatggtg 2445421 gcgaacgtca gtggaaatga cgacatcccc tacattcaat gtatgatgaa atccgccggc 2445481 tgagcctgtg ttaatgacat aatcaggctt gtaacggtca agcagaagcg tcgtgctgat 2445541 agcagcattt acttttccaa ttcctgattt taaaagaatc acttcagttc cttcatattc 2445601 gcctgttgta aattcacagt gtgcgatcgt ttctgttttt gcattttcaa gtttgtttct 2445661 taagatggta acttcctctt ccattgctcc gatgactgct agtctcatct attcacattc 2445721 ccttcacttt accgtttgat cgcctccatt atccacacga agtcgttttg ctgagtgaat 2445781 cggactgcaa aaccttcagc tgtaaacatt tctttcaacg catccaatgt aggataatgc 2445841 tctgtctcta aatcatttgc aagctgataa aagccttgag aacgggcttt atcgatagcc 2445901 tgttgatacg cttgcgcatt ttcaaagacg gtatcggcaa acactatttt atcatgcaag 2445961 tgaaggtatt tgccatattg ctttatggca gcccgctttt cttcgtcagt caaatgatga 2446021 aaagcatatg aactgacaat cgtatcagcc tgaaatggcg gctcagggaa tgtcaggaag 2446081 tctccatcaa cgatttccgt cctgcctgag agcttgtcag aagccagttt acgcattgct 2446141 ggagaaggtt cgattccaaa tacagttttg cctgcatcga gcagcttagc tgtcaaattc 2446201 ccggtccccg ggccaaattc taacacatgc gttccagatt ttctgacgat ggcatcaagg 2446261 atatgatcgt agcctctgaa cgcttcttta tactgaatat ctaaaccttg tactgtttga 2446321 tcataagttg ctgcccaatc ttcaaagaga gggataaatt cacggcccat atttgtcaca 2446381 ctccatattt aataattcct ataagtatac tatggattaa tgatggaaca gttcctataa 2446441 taccacatat tctgaaaagc aggtactaaa acactttgtg tattttatgc catctcatat 2446501 tgcgcattga ccgcaaaaaa gcttatactt catatgactt gtgaaagctg gagggtcaag 2446561 acatgaattt tcaattagat ctgattaaag acaaagtgga attttttgaa gcggcttcat 2446621 tgcaggagct tgaaaagaaa atcaatacac aaattgaaaa caataaagcc atcatgctcc 2446681 gggtgaaatc tgtttcacac caaactcttg tggcagaagg aagaatattg tacagcgcgg 2446741 tggttcattt ctcagctgaa gcctaaaaca aaagcagccg gttttaaccc ggctgctttt 2446801 gtttatttta gcttttctac ttttgtcggc ttccagcctt tttcatcgac ccatgtaatc 2446861 gtgacttgat atttattccc agtcgccttg tccaaaatct tgcctttggc atcctgaggg 2446921 ctgccgttat ttccaagcca gagcaccgtc atgttatctg ttgagacacc agttgcgtac 2446981 gaaatggctt tcagcatctc agcccagtct tgtgagcttg aatcataagt agcggcatgc 2447041 tcgccagtct gctcagttcc gactgctttc cagtcaggat tttcatacgt tttttccaca 2447101 tcgctcgatg agccgccttc tgttactttt gcatctttaa gcccgtcacc ggctgaatct 2447161 gagcttgaat ctgaatcaga gtcatctttt ttagaagaag aatcatcttt tttggaatca 2447221 gagtcagaag acttctcaga atccttttcg ctgtcagatg tatctttctt gctgtctttt 2447281 atatcctcat ccgatttctt ttccgtcttt cctgaagccg gagattcctg tttttgcgcc 2447341 gtttcagaat ccttgctgac atctttgcta gaaggactgt taatgaagag attcgctgct 2447401 actacgacaa ttagtatgga tacgattgcg attaaaatgt taagcactaa attggctttt 2447461 ctgcgtttat cacgattttc ataacgagat tgattattgc tcaataattc tgcactcctt 2447521 tatccctctt ggctcagcat atattttaac atgtgctgag aagttgttct atttctgatt 2447581 gatttcaatt tcgtgtactt ttttaacaat atcataaaac accgaatttg tcagagcctt 2447641 atctcccggt gtatccatgt gtaaaacaac tagagcgtat ttcggcttat ccgcgggaaa 2447701 atatccggca aaccattttt cgtagagcgt ttccttctct tttgaaagct tgcctgtctg 2447761 ggctgtgccc gacttccctg ctacagtata cggaagatct tgaaaccttc tgcccgttcc 2447821 ggaaggagat tctactaccc gccgcagtat tttttgaagc tgctgtgacg tatatttgtc 2447881 tatcgtttcc cctttgagct tctgatcttt aaacgtaacg agcgttgtgc cgttcttata 2447941 ctcaatttgt tcggcaattt tcacctgccg tttttctccg ccgcgggcga ttgtcgccat 2448001 catattggct acctccagcg gcgttacctt tacatttttc tgcccgattg ctgtttgcgc 2448061 aatggctttt ttgactgatt tgtctttttc atccccccaa atcacgccgc ttttttcgtt 2448121 atacagctgg cggaaatcgg tttcgtggta cagttttccc tcccagcctg cccgatcagt 2448181 gagagccagc ttctcggaca tatcttcaat aaccgagctg tcttttttca ttaattgttc 2448241 tgcaagactc gtaaatgtgt aattacagct ttgggcaaaa ctttcatcaa aagacaaggt 2448301 gcctttgtcg tcccccggtt ccccgtacag gtttaaattg caattaaagg tttgactagg 2448361 cttcaccata ttattttcga ttgcagctgc ggcaatgact gttttaaaaa ctgatccggg 2448421 atagattggc gtcagcatat aattttgaag tgtgttttgc cgggacacgt ctgcatctgg 2448481 tttgcttaca attcccagaa cactgctatt ttcgatgtcc agcagcacag ctcctccctt 2448541 tttcagcccc tgttcatcca atacctcctc catcgctttt tgaatgcttt gatcgatcgt 2448601 tgttttgatc tggagcggat aaaatgtatt ggcttcagct gtatatttga cgtccatgcc 2448661 aaacaaaggg tttccttttc cgtccacatg atataaaagc tttgtgtctt gttccggaag 2448721 caaaaactcg tcaaatgtcc gttctaaacc ggttgttccg atttctgttg taatcggaag 2448781 gctctccttg tcaggatatt tcttgcgaag cagcgccgga tcttggttcg tgctccctat 2448841 cgtatgtgaa gcaaggctgg gcttgtcttc attctccata tatacgccgt aaatgccggg 2448901 atatttcaaa gaattgattt ttgtgataga ttgttttgaa agtgttttga ttttcttttg 2448961 ctgcaaaatg accggttttt ttgcctgacc tagtgtctgg cgcaaatcat cttcagacat 2449021 gccgaggatg tccgcaactt ttttgatcgg ccaatcctgc gtcagcagaa aagggaacaa 2449081 aacaaccgca ggctcgcttt gtcctgtcag cgcccgcccg tttcgatcta aaaaagagcc 2449141 tcttccatct gaaatgagca cttcctccgt ccgctgtttc acactttctt gaatcaaatt 2449201 aattttcttt ttagaaaatg attctgtgaa aaacagctgg atttctgcaa gtctcagcag 2449261 aagcagaaaa aatacaatca aaaaagcgat gactgccagc ttcattcgtt tcgatatctt 2449321 cataaaaaaa cacctcaccc acattgtgga cgaggtgttt cgctgctaaa cagatattat 2449381 gaaattttca caattttcac gagcatttct ccgcccggtg tttgtactgt gacttcttca 2449441 tctacttttt tgcccaagag gctttttgcg atcggtgaat cgtttgagat tttcccttca 2449501 aacgggtcag cttccgcgct tccgacgatc gtatatgatt cttcatcacc gtcaggcagt 2449561 tcgacgaaag tgacggtttt acccaaaccg acaacgttag agccgccgtc atcttcaatg 2449621 attttcgcat tgcgaatcat attttcaaga gtcgtcacgc ggccctctac aaatgcctgc 2449681 tcttctttcg ctgaatcgta ttcagagttc tcggaaaggt ctccgaagct tctcgcaatt 2449741 ttgattcgct ctactacttc ttttcgttta accgttttca aatattctaa ttcttgttca 2449801 agtttttgtt ttccttctgc agtcatagga aaaactttct cttgtgccat gtcccttcac 2449861 tccttctggt tgtccctcaa catcttcgat tatgtatgag agcataaact aaaaaataca 2449921 agaatgagaa cacagggcag tcctcgttct tctctcccat ataggtactg tttatcttaa 2449981 actgaatcgt gtcgttctgc aaatatttcg cgtttataaa cagggaaaga agggaattcg 2450041 cacattccct tcctgcctat acataatatg gtcagagtta tttatgtcta tgctatggta 2450101 ttacaaaatc gcgttttgtt caagaatggt ttgaattttt gtgaccatca gatcaattgc 2450161 gacgtgattc tgaccgcctt ccgggataat aatatcagcg tatcgtttcg tcggctcgac 2450221 gaattggtta tgcatcggac ggaccactga cacatattgt tcaatgacag aatcaataga 2450281 gcgtccgcgc tcattaatat ctctcataat ccgtctgatg atacgcaagt cagcgtccgt 2450341 atcaacataa agcttgatat ccatcagatc acgaagcctt ttgtcttcaa gaacaagaat 2450401 gccttcaagg ataataacat cctttggctc tacgtgaacc gtttcttctg aacgtgtgtg 2450461 aagcttatag tcataaatcg gcttttcaat cgggcggtaa ttcaatagat cttgaatatg 2450521 ctcgattaaa tagtcattat caaacgcaag cggatgatca tagtttgtgt tcagcctttc 2450581 ttcaaacgga agatggcttt ggtctttata ataaaggtcc tgctggatca ttaaaattga 2450641 gtgtccttta aactgttcat aaatggaccg tgtgacactc gtttttcctg aaccggaacc 2450701 tcctgcgatt ccaatgacta ctggattctt acccatgggc tgttacttcc cctttctcat 2450761 catgttgctc ggataaatct ttttgtctag tttgaatttg acaatttgca ggggatggcg 2450821 ggcagcatct agctcatttc cgtcttcgtc ccaaatggtt tcaatcgtat gtgtaaagtt 2450881 ttcgatttct ggaccgaaaa attccacttc gtcgcctttt ttgaagaaat tgcgctgctg 2450941 aagcgtgacc atttgtgtat cttcatcata attcagcact aagccgacaa aatcatatgt 2451001 cgttttcttg gcgtgttcgc cgaacatttg ctcttcatag cctggcgttc cttcaaagaa 2451061 agctgtcgca gtgtccctgt tggcgcactt atcaagctct tcaagccatt ctttttgaat 2451121 cacaaagttt tctggatcag cgcaataagc atcgattact ttgcggtata cgctgacaac 2451181 agttgctaca tagtgaatgg atttcatgcg gccttcaatc tttaagctgt cgatccccat 2451241 ttcaatcatt tttggaatgg attcaatcag cttcaaatct ttcgggctca tcgcaaatgg 2451301 tgcatcttct tcaccataca aagcaacggc gttggcaccg tctgtttggt agagatcata 2451361 atcccagcgg catgactggc agcagcctcc gcggttggaa tcccgcgctg tcatgtgatt 2451421 gctcagcacg cagcggccgg aatatgcaat acacattgcg ccatgaatga aggattcgat 2451481 ttcgatatct accttttctt tcatttctct gatttcaaga gcgctagttt cacgtgccag 2451541 cacgacgcgg tcgagacctt cttccttcca gaactggaca gccttccagt ttgaaagaga 2451601 ctgctgtgtg ctcaagtgaa cctcaacatt cggcgccact ctgcggcatg tttcaataat 2451661 aagcggatct gccacaataa taccggcaac gttggcgtct ccaagcgctt ttaaatagtc 2451721 ttcaagcccg tccatgtttt cattatgagc gaaaatattc gttgttacgt agatcttcgc 2451781 gccatatttc tttgcgaatt caacgccttc tgcaatttct tcgatcgtaa agttatcggc 2451841 attcgagcga agcccgtatt cctgtccccc gataaagacc gcgtccgctc cgtaatgaac 2451901 agcgattttc agcttttcaa gattacccgc aggtgcgaga agctccggct ttttcgtaat 2451961 cacacgcttt ccattaacga ttgtggatat tttatcattt acggcagtca tagcttaacc 2452021 tccttttgat taataaaccg tttccttgaa gaagaatccg gtatcaattt ttctgtttac 2452081 tggctggatg ctttcaatgc gttcgatcca gtcttctttt ttcgcttcgt attcgtcacg 2452141 gttttccacg cacaaatcaa ttgcttctct gtacattttg gtgacttcta ttaggtattc 2452201 aggcattttc aaaacaccat cgattttgaa agaatcaatt ccggcatcta tcaattcctc 2452261 gagctcatca atgatgcaca catcgttcgg gctcatgatg tgagtgccgt tttcatcttc 2452321 gaaaatcgga tatttattat cgcgttcttt atcgtgtaaa aacatgcctg attctttttt 2452381 ctttctttca atgtccatga ctttgccctg atattcaaaa tagtttccaa tcaaagaacg 2452441 cttcgattgg aacatgcacg tcattccatg cacctggatt tcaatttcga cttcagcatt 2452501 ttctttaatc tcaacaatgc tgtccatgtt taattctctg gcaagcacag aacgcgccgc 2452561 acccttgcgt ccccagtagt tgcatgtata atagttggtg cctgtcgttt ctgtgctcca 2452621 atgaagcttc agatcaggcg cagattcacg ggcagccatc agcacggcag gatcgccgaa 2452681 taccgctgca tcgacaccgg cttctgctaa gaaagccaga tattcgccaa gctcacccac 2452741 tttatcatta tggaaaattg catttacagc aacgtatact tttgcccctt ctttgtgagc 2452801 aatctctacg gcttttgtta catcttcacg agaaaattct ccggctaatc tcaagccgta 2452861 tctctgttcc ccaactaaaa acgcagttgc cccagcctgt atgagcggca aaatgtccgc 2452921 tgtactcgtc ggcgtcacta agagctctgg ttttttcatg acgttcacct cttcttttta 2452981 ctaatcgcaa gtccgtcccc gacaggaata atcgcagttt gataatccgg atgattcatc 2453041 agccaatgat tatattcatc aattttggct acaagcctgc gccttctctt cggttctatt 2453101 ttgctgtaat cctctgccac cagaccttta aacagcacgt tgtctgttat aatcaccccg 2453161 tccggtgaaa gcatcggttc atataaatga aaaaagtttt gatactgacc ttttgcagcg 2453221 tcaataaaaa tgacatcgta aggcgcggtt acatgaacgg cgtcggctaa ttcaagcgca 2453281 tctccgtaaa aaacatgaat ccggtcatca agctgaaatt ccttgatatt gtttaccgct 2453341 tcttcatgcc gtttctcatt gcgttcaatt gtatatattt cagcagacgg cagttccaga 2453401 gccattcgaa tggctgaata accaatggcc gttccgattt ctagtatttt tttcggctgt 2453461 ttcacagaca aaatttgaag cagcacctcc atgcccgctt tttccataat cgggacatga 2453521 tgttcttctg catatgcttc aagtctcttc acgttatccg gccgaggctt taataatgct 2453581 tctatatagt catttatttg ttcataccgg tcagtcacta caaacagcct cccgttctaa 2453641 aaaggagtgc cccagtctta tgcgcaggac actctctgaa tacatcatga tacatcggta 2453701 aacaacccga tatattttat cataaaacct tgcggaaagc gaacaaaagg agagcttttt 2453761 gctctccttt tatttctcat tttttgagga aatgtatttt tcttttgctt tattatgctc 2453821 ttttagcgtt tttgtaaata cgacctcacc atttgatttg gccaagaaat acagatagtc 2453881 cgttttatcc ggatgcagcg ctgcttccca tgatgacatg ccggcattgg caatcggccc 2453941 tggcgtcagc cctgtgtttt tatacgtatt gtatggtgaa tcgatttcca gatccttata 2454001 aagaacccga tctttatgct tgcctgccgc gtacaggacg gtcggatctg tttggagcgg 2454061 cattttcttt ttcaggcggt tataaaagac gctcgcaatt ttatggcggt cggctttttc 2454121 agtcgcttct tcttctatca aagaagccat tgtcagcagc ttatgcacag aaactttgtt 2454181 tttcttcatt tctgatttat atgtttccac ataagaattt gtctgcttaa tcattgcctt 2454241 gataatgtct tcaagtgatg tgtccggatc gttaaaaggg tatgtagccg ggaataggta 2454301 cccttcaagc gggtgcttaa tgtttttatt gaaaacatca tttgtcacag tgtccgggaa 2454361 ttctttcttc agctgattga taaatgtttc atcgtccagc ttcgctatga cttgtttttt 2454421 agagtatttt gtttcatcag caatagcagc cgcgatttgg gtcagctgtg ctccctcagt 2454481 cactgtgatt tgaaaagcgt aacctgtagc cccgcttgtc agcttctgaa taatggcatc 2454541 taaatccata cctttattca gatggtagaa tccggcctga aacccggaag cacctttata 2454601 tttcacatag tactgaaacg ccttctcgct ttttatgaca tcatttttct ttaatatcga 2454661 tgcgatggct gaaacagacg aaccgctcgg aatgttaata ttaactgtcg ttttactgtc 2454721 tttttcaaca ggttcaagca atgatttccc atataaaaat gccccgccaa tgatgagaaa 2454781 cagcacaaca atggaagaca gtatgattct ttttttatta aaaaacgatt ttttttgctg 2454841 attgatatac attaggtctc ctcccatcag ctcttatact acatgattca ttgtatttcg 2454901 gcaatttatt acaaaaagag gcctgcataa agcagaaaaa agccggagca gtatagctcc 2454961 ggctttggtt tggcgcgatg ttttactctt cgtcttcgtc cgctaagaat gtgtttagtg 2455021 tttcttcgat catatcccat tcttcgtcag tttcaatcgg gaatagctca ccgttttcac 2455081 cgtcttcgtt tggcgtgaag ctggaagcaa gaatttctac ttcttcgtca tcttttgatt 2455141 cgattggata gtacaagaca taagatttgc caaactcttc attttcaaat gtaaacagca 2455201 cttcacaaag ctgttcattt ccttgatcgt caacaattgt aatatttttt tcgccgtgtt 2455261 ccattttctt cacctctggc tttaatttaa gctgtcaaga tatccttgta aaatcataac 2455321 agccgccatt ttatcaatga ctttttttcg tttttgcctg ctgacgtcag ctgcaatcag 2455381 cattttttca gccgccattg tggtaagacg ctcgtcccac agcacaacag gaacattgta 2455441 cgttgtttca agcactttcg caaatgtttg gctggcttcg cctctcgggc cgactgttcc 2455501 gttcatgttc ttaggaaagc cgagcacgat tttatctata gtatagtcct ttatcagttc 2455561 agataaacgg gataaaccat aatcgccttc tgcttcattt atctttatgg tctcaatgcc 2455621 ttgagcagtc cagcccattt catcgctcag agctacaccg agtgttttgg ttcctaaatc 2455681 gagtcctaat attctcattc tttatttacg cctctttatg ctgttctaaa taagacttta 2455741 ccaattcctc gattaattcg tctctttcaa gtttgcgaat taaattgcga gcgtcacgat 2455801 gcctaggaat ataagcggga tcacctgaca gcaagtatcc gacaatctgg ttgattggat 2455861 tgtagccctt ttcctgaagc gcgtcataca ctgtaatcag cacctcattt acgttagtct 2455921 cagcagaatc atcggagaaa ttaaatttca tcgttttatc aaacgagctc accgttttgc 2455981 acctctttcc caaattcgca ggcaaagttc agcctggggt cctaatctta ccatcattct 2456041 acactacatg ggcgaattat aaaacggatt tcacccaatc ttctacagaa gccaaagctt 2456101 cttctaattt ttccggctgt ttaccgcctg cctgcgccat gtccggacgg cctccgccgc 2456161 ctccgccgca aacttccgca gcttgtttaa ccagcttgcc ggcgtgaagt cctttctcaa 2456221 tgaggtcctt tgtgactccg gcagagatat taactttatc gttttgtacc gcaccaagca 2456281 cgatcaccgc agagccaagc tttgctttga gttcatcgac catagtgcgg agatgattca 2456341 tgtcttttgc atttactttt gccgcaagca cgtttacgcc gtcaacttct tttactttcg 2456401 acaggattgc tcctgcttcc acgttgccta gttttgcaag aagagattca ttttctcttt 2456461 gtgcatcctt cagttcagcc tgcagagccg cgacccgttt cggcacttct ttgatatttg 2456521 ttttcagctc gtcagcggtc tgcttcaata cagaaatctg gctgttcatt tcgacgtaag 2456581 cgccttgtcc cgttacagct tcaatccgtc ttgtgcctgc tccgattccg gattcagaaa 2456641 cgattttaaa caagccgatt tctgctgtat ttctgacgtg gcagccgccg cacagctcta 2456701 agctgtaatc tccaacttga acgacacgga caatatcgcc atatttttcg ccgaacagtg 2456761 ccatcgcacc catttctttt gcttcagcga tcggtttcaa atcaatgctg accgggatgc 2456821 tcgcccagat cttttcgttt acgattcttt caatttgttc gagctcttct tttgtcactt 2456881 ggccaaagtg cgagaagtca aaacgaaggc ggttttccgt tacaagagag cccgcctgat 2456941 tgacatgagt tccaagaaca tcttttagag cctgatgcaa taaatgcgtt gccgtgtggt 2457001 ttttaatgac gccgcttctc atatggtctt caacttcagc cgtaacatgc aggccttttt 2457061 gaacagtacc gctctccaca acaccttcat gcacatgctg gccgttcggc gctttttgaa 2457121 catctttaat tcttacaact gcctgctcgc ttcggagata gcctttgtcg ccgatttggc 2457181 cgccgctttc tgcatagaac ggtgtttcat caagaatgat ttgaacgctt tctccttcat 2457241 gagcctcttc gattaattgg ccgtcctgaa gaagcacaat gatattggca tcagctttgg 2457301 tttgagagta gccgacaaat gtgctttcaa ctgtcacgtc gcgcagtgcg ccgccctgca 2457361 cctgcatgct gccgacatcc tggcgggcgt ttcttgcccg ttcacgctgc tggttcattt 2457421 cctcctcaaa gccctcatgg tcaaccgtca tgttctcgtc ttctgcgtat tcttcagtca 2457481 attcaaccgg gaatccatac gtatcataca gtttaaacac atcagcacct gagataacgc 2457541 tgctgccctt gtctttttct tttttgatca tttctgacag gatcgcaagc ccttcattaa 2457601 gggtctcatg gaagcgttct tcctcggttt taatgacttt tgcgatgaaa tccgctttct 2457661 ctttcacttc aggatagaaa tcagccatga tttctgcgac aaccggcact aaatcaaaca 2457721 tgaacggacg atggatgttg atcgttttgg cataacgcac ggcacggcgt aataagcgtc 2457781 ttaatacata gccgcggcct tcatttgacg gcagcgcacc gtcactgaca gcaaaggcaa 2457841 ccgttctgat atggtcagca atcactttaa acgcagtgtc tttcacattg tctttgccat 2457901 atgtttcacc agaaatcgat tctgttgctt taatgatcgg aacaaacaaa tcggtgtcaa 2457961 agtttgtcgg aacattctgg atgacagaca ccattctttc aagacccatg cctgtatcaa 2458021 tatttttctt tggaagcggt gtgtacgtgc cgtcagggtt atggttgaac tctgagaaca 2458081 caaggttcca tacttccagg taacggtcgt tttccccgcc tgggtaaagc tccggatctt 2458141 ctggatcatt accgtatgct tcaccgcggt cgtaaaagat ttccgtattc ggtccgctcg 2458201 gcccttcacc gatatcccag aagttccctt ccagacggat aattctttct tcaggaatac 2458261 cgattttttt cgcccaaaac tcatatgcct cttcatcttc aggatgaacc gtaacagaga 2458321 gaagctcttt gtcgaagcca atccacttgt cgctcgttaa aaactcccaa gcccatgtaa 2458381 tggcttcttc tttgaaataa tcgccgatgg aaaagtttcc gagcatttca aagaaagtgt 2458441 gatggcgcgc agttttacct acattttcta tatcgtttgt tctgatcgct ttttgagcgt 2458501 ttacgattct tggattttcc ggcacgacac ggccgtcaaa atattttttc agcgtcgcaa 2458561 caccgctgtt gatccaaagc agtgaaggat cctcatgagg cactaatgac gcgcttggct 2458621 ctaccgcatg tcctttttct ttaaagaaat ccaaaaacat ttgacgcact tccgcagaag 2458681 ttaagtgttt cattgtattt cctcctctat aaaaatcgaa attctcttca gtgacagcaa 2458741 aaaagccctc cccctatgca aaccaacgtt tacacaggga cgagagctgt ctcgcggtac 2458801 caccctgatt acgggcattc atgcgcccgt cacctttaac cctgtaacgc aggataagcg 2458861 gcagtgatta actgcactca ggattagctt cctccgatct tctgataaag ctcctttcag 2458921 cttatggagc ttctctcttt aacagggctt cggcgtactc agatccgtca ctcgagattc 2458981 gtatgtattc tacgagaaat tatagacaag cggcacgccg atgtcaatgc tccgtcctca 2459041 tccgcaaaaa atggatcatc attactttta aaacagccgt cgcaggaaca gccagaatca 2459101 tcccgacgat acccgcaagc tcccctccgg caaggagtgc aagcatgata acgaccggat 2459161 gcattttaag gcttctgccg acaatgaacg gactgaggat atttccttcc ataaactgca 2459221 gaataaacac cgtaatcacc acaacaagaa ccgccttgac tgagatcgtc atcgcaatta 2459281 acaacgcagg aacagctccg atgaaagggc caaaatacgg gatgacattc gttaccccag 2459341 agataaggcc aagtatcagc ggatacggaa gcccaaatac ccagaacgaa atgcctgcaa 2459401 tcacgccaag aatcaagcag accaaaagct ggccgcggat ataatcgcca agcgaatcat 2459461 ccacatcccg caaaaaggcg ctgccccgct ttctccacga cttcggagtc aagtaccata 2459521 ctgtcttttt cattaactca atgtccttca ccatataaaa cacgagaaaa gggattgttg 2459581 cagcaattaa gaagtaatca agcacattgc ggatcccgct gatcgcaccc tcgatcgttc 2459641 ccgcaaaaaa cgcctccgtc tggcggatca ttttatctat acggtgatgc ataccatcag 2459701 gccagtcatc cgtatggtta tgcacatgaa gaagaagccc gttatacgtt tcggcaaaca 2459761 tgggtatatt ttctgacaaa tccgtcagct gcacgattaa aacaggcacc cctttataca 2459821 acgcccagcc aatcccgcca aaaaaaagaa cataaatgac caagatgctc aaagtcctag 2459881 gcaatccttt gccatgcagc cattctgtga ccggaagcaa taaataagat ataaaaatag 2459941 aaatgatcaa gggaataaag atcgttttta tgacgagcca aaagggtgac cataacatat 2460001 caagcataaa aaagacatag actgttaaca gaaccagcaa acaaatagcc acccacaaca 2460061 aaagctgcac cggtttttgg agcatctgct ttcacctcac ctatatcttt tgaggtttac 2460121 aaggaattat tctttatgtt tctttagtca gtcagaagtc atggacattt tttcactttt 2460181 aattttcaga aaagtttgat catttacttt ttggtcaaat tttctgatag gaggattgcg 2460241 atgatcacat ttcaaaatgt aaacaagcat tacggagatt ttcacgtgtt aaaacaaatt 2460301 aatcttcaaa tcgaaaaagg tgaagtcgtt gttatcatcg gcccatccgg ttccggtaaa 2460361 agcacattgc tcagatgcat caacagactt gagtcgatca atgagggagt gcttacagta 2460421 aacggcaccg ccattaacga cagaaaaact gatatcaatc aagtgcggca aaatatcggg 2460481 atggtgtttc agcactttca tttatatccg cataaaacag tgctgcagaa catcatgctg 2460541 gctccggtaa aagtgcttag acaatcacct gaacaagcaa aggaaacggc gcggtactat 2460601 cttgaaaaag tcggcatccc agacaaggct gacgcctatc cttcccagct ttccggcggg 2460661 cagcagcagc gtgttgccat cgcaagagga ctggcgatga agccggaggt catgctgttt 2460721 gacgagccga catcagcact tgatcctgaa atgatcggtg aggtgctaga tgtcatgaaa 2460781 acactcgcca aagaaggcat gacaatggtt gtcgtgacac acgaaatggg gtttgccaaa 2460841 gaagttgccg accggattgt cttcattgac gaaggaaaaa ttttagaaga agcagtgccg 2460901 gctgaatttt acgcgaaccc gaaggaagaa cgggcccgct tattcttaag ccgtatttta 2460961 aatcattaaa acagaaatgg gggagcttgt atgaaaaaga ttttttcttt agcattgatt 2461021 tctttattcg ctgtcatctt gcttgccgct tgcggcagca agggatcaaa cggagaagcc 2461081 tcaaaggaga gcaaaaaaga tacgctagcc gccattaaag acaatgacaa aattgtcttc 2461141 ggcgtaaaaa cggacactcg actgttcggt cttaaaaatc caagctcagg tgagattgag 2461201 ggttttgata ttgatattgc taaacaaatc gctaaagaca ttttaggtga tgagaaaaaa 2461261 gctcaattta aagaggtcac ctcaaaaaca aggattccta tgctgcaaaa cggggatatc 2461321 gacgccattg tcgccacaat gacgatcact gaagaacgaa aaaaggaagt tgacttttct 2461381 gatgtctatt tcgaggccgg gcaatcgctt ctcgtgaaaa aaggcagcaa aatcaagagt 2461441 gtcgagaatc ttggcaaagg ctcaaaagtt cttgcagtaa aaggctccac ctcctctcaa 2461501 aacattcgtg aaaaggcgcc tgaagcatct gttttagaat ttgaaaacta cgcagaagcc 2461561 tttacagccc ttaaatcggg gcaaggcgat gccctcacca cagataatgc aattttatat 2461621 ggaatggctg atgaaaataa aaattatcaa ttaacaggaa agccttttac agatgagcct 2461681 tacgggatcg ccgtgaaaaa agggcaatct gctctcgcga aagaaatcaa cgcttcactt 2461741 aaaaagatga agtcggatgg cagatacgat gaaatttata aaaaatggat caaagaagac 2461801 ccagctgaat aacaaccatc ccgggatgag caggcgatgc tcatcccaat ttgataagga 2461861 gtgaataggc agatgaatgt gtcaattctt ttcgataact tcagcatgta tatggacggt 2461921 ttttaccata ccttgctcgc aagtgttatc gcgctggccg gcagttttgt cctcggcgtt 2461981 gctgtagcgg ttatgagaat aacagtcttt aagccgctgc aatggctcgg gaccgcatat 2462041 gtagaattca tccgcaacat ccctcttctt ttaattacct ttgttttcta tttcggactt 2462101 ccaaacgcag gcctgaggct tgacggtttt caagcgggaa cggttgctct caccatttat 2462161 acctctgcgt ttatcgctga agccatcaga gcaggcatcc agtctgtttc aaaagggcag 2462221 atggaagcgg cacgctcgtc aggctttacc tacagccaag ccatgctcca tatcattttg 2462281 ccgcaggcaa tcaaaatcgt cattccgcct ttaggcaatc aatttttaaa cttagtcaaa 2462341 aactcttcga ttcttggggt tgtggccgga ttggatctta tgtaccaagc cgatttagtt 2462401 tcgtcgagca cactcgttgt atttgatgtt tatatttttg tggcgctttt ttacttagtg 2462461 ctgacgattc cgcttagcat cggtgttaac tatctggaaa aacggctgga aaaaagctat 2462521 tgataaggag tgagttacat tggatttcat cggtgcttat tcacaggagc atttagcgtt 2462581 tttatgggat ggctttctcg tcaccttgta cgttgctttc atctccatca ttctgagctt 2462641 tttcttcggt ttaatcgcag gcaccctgcg ttatgcgaaa gttcccgttc tttctcaatt 2462701 gattgcagtt ctcgttgaaa cgatcagaaa cctccccttg ctgttaatta ttttctttac 2462761 gttttttgcc cttccggaaa ttgggattaa gcttgaaatt acagctgctg caattacagc 2462821 actaacgatt tttgaatccg ctatgctatc tgaaattatc cgaagcggac tgaaatcaat 2462881 tgacaaagga caaattgaag cggcgcgctc ctccgggctg agctatacac agaccctgtt 2462941 ctttatcgtt atgccgcaag cgcttcgccg catggttccg cccatcgtaa gccagtttat 2463001 ttctttatta aaagatacat cgctcgctgt tgtgatcgcc ctgcctgaac tgattcacaa 2463061 cgcgcaaatt attaacggcc aaagcgctga cggcagttat tttttcccga tctttttact 2463121 tgcggccctt atgtatttcg cagtcaacta cagcctttca ctcgcagcaa gacgcctcga 2463181 ggtccggcaa acatagaaaa ggatactctt tggagagtat cctttttgca ttaaaacatt 2463241 ttcgtaattc ttcttctcat ccgcttcatg cttcgattat tcagcatgtc agattgagtc 2463301 gccattcggt acacgagagc tccggctccc attgccaaaa gagaagtcat cgtccgattc 2463361 atcctgcgca tctcctttca tgattaaaaa ttgatgctgc gttcatcctc agaaaacaaa 2463421 tcatccaagc tgcttaacgt tccgtcttct tccacctgat gagttgcaat cttccctttc 2463481 gccactgtca gttcaataaa acagccccag caataatatt ggttcacgcc gattttgccg 2463541 atatccttac ttttgcaatt cgggcatata agcatacctc acacctctat ccgttcagaa 2463601 cgatctcgtc tttccgcacc tcgacaagcg aatccgctct ttggatctgg cgcttgcttc 2463661 ccgccaggtc agaaaagaaa ccgtccgaga gttcatatgc tacgattatg cccctgtcca 2463721 aacaaaagta tacatcttcc agcatcccca atatatcccc ctcttgcgat ttcacaagct 2463781 tcatcttcat ctgctcgtat gtgaagcatg atttcggaag aggcaaaagc tgttctgaac 2463841 tgaccgaagc caatatgcgg tcatcaaaaa tggaagagat atcacacgcc cgtaatagcg 2463901 catgatgatg atgcaaaaag cgtttttgtg caagaataaa cccaagacaa tctcctttca 2463961 gagaaaaaca aatatcggaa attgtcccga gataactaga agttcgttct gagtatactg 2464021 ggaatccttc tacttcatgg catgttctca aagtgtgatc aaccaccttt tgttgaacag 2464081 gcttaggttt tgctttgcgc cttagactca tacgatgaaa tcaattccac tgcaaatgaa 2464141 aaaaaactcc cgcttgcacg ggagcatttt attgctgttc ttctttcata aaatcgaatg 2464201 gtgtaatgcc ttccatgcca atgttggcgt cgtgtacgct gaacgggagc tctttttgca 2464261 aagcttcaag ctcggcatcc atttcctcaa cctgtacgga cagcctgttt ttcaaggagg 2464321 tctgtctgac agttgcatca ttatttttca cgccccactc cagcgcctcc tcttccccgc 2464381 ataaaatgag aaatttcttc gctcttgtaa tcgcggtata aagaaggttt cttctgagca 2464441 ttctataata gcctttcaca acaggcaaaa ccacaatcgg aaattcactt ccctgcgatt 2464501 tatgaataga acagcaatac gcatgggtaa attgattaaa atcttttttc gtaaatgtca 2464561 tttcattgcc gtcaaaagaa acgacggcca tgtcttcttt ttctgtattt tcctttgcat 2464621 aaaatatcga cgtgatttcg ccaatatctc cgttgaacac attgttttcc ggctgattga 2464681 caagctgcaa aattttatct ccggttctgt agacaacatc cccgaacttc aattctctcc 2464741 gtttttcttt aggaggattt aaaatgtcct gcagcatcac attcaattca ttaatgccgg 2464801 cttttcctct gtacatcgga gcgaggacct gaatgtcctt tgctgtatag ccttttttca 2464861 atgcattggc gacaaccttc tcaactactt ctttgatttg cgacccgccg cagcgaataa 2464921 aggaacggtc ctttgtcggg gcagtcaaat tgttcggcag caatccattt ttcatctggt 2464981 gggcaagctc gacgattgat gacccttctg cctggcgata gatgtctgtc agtctcacag 2465041 tcggaatcac ctgggatgcc agcaggtctc tgagcacttg tcccggaccg acggaaggca 2465101 gctggtcttc gtctccgaca atgatgattt gtatatgatc agggatcgcc ttgaacaaat 2465161 gattcgccag ccatatatca agcatactgg cttcatcgat aattaacagc ttcccttcga 2465221 tcggctgatc ctctgtatga gtaaagcctt cagcgccgtt ccagccaagc agcctgtgta 2465281 tcgtaactgc agggagtccc gttgattcac tcatccgttt tgctgctctc cctgtcggag 2465341 cggccaaaac aatcggaaaa gcttcatcct ttttataagc tgacgggtct agtgacacac 2465401 cgtgaagctc tccgtagagc tcgacaatcc ctctgattac cgtcgttttt cctgttcccg 2465461 ggccgcctgt taaaagaagc atcggcgagg aaagggcttt ttgaatcgct tccttctggc 2465521 tgggggcata ctgaacgtcc atccgttctt ccagttctcc caacgcgagc aaaaactctg 2465581 attcgggaaa ctggttctca tattcggttt ggctagcgat atgtttcaca cgctttgcaa 2465641 cgttttgttc tgcgtaaaac agcgaaggaa aataacagcg gccatcttct atgacaatgt 2465701 ctttattttc tccaagggca ataattgcgt tagcggcatc catttctgta atgcgctgcc 2465761 cttcccttgc tgactggttt aacagtgatt gagtgtcgat gatcagctgt tccgtttcta 2465821 tgtacgtgtg cccctctgac agacaagtcg tttcaagcgt gtacaaaata gcagctttta 2465881 cccgctcagg atgattaccc gaaagaccca ttctgctgcc cagctcatcc gcttttccaa 2465941 acccgatgcc ttctacatcc ttcacaagct gataaggatt ttcctgaatc ttttcaagcg 2466001 tctcggattc ataggcttga tagattttca tagacagctg cgggccaaag ccaaactgat 2466061 tcaaggaaat catgatttgc tccagtccct gatgccgctg caatgcgcca gccagcgtgt 2466121 ctgctttctt ttttgagagt ctgggaacat cataaagcac tgaagcatca gccaatattt 2466181 tattaatggc gctgtcgccc agctttttca caatttcttc agctgttttt ttgccgatcc 2466241 cctcgaataa atcactcgat aaatattgaa tgatgccttc cttagtcgtt ggaatctcct 2466301 ttttgaaatg ctccgcctga aattggagcc cgaattttgg atgggttacg atctttccgt 2466361 aaaacgtgta ggtctcttct tcttgaagcg cagggaagta gcccgtcacg gatacggctt 2466421 tatcttcaat ggcttcggag gtctctgtga ctttcacttt cagaaccgta tataaattgg 2466481 tgtcattatg atagatgact gtgttgactg tcccttttaa atagggctct tcctccagtt 2466541 taagctgatc cggatgctgc tgcacgagct gtccctcctc ctgtgcctgt tatgatggat 2466601 caatcagttt tttagcatga agcgcaagca tatgatctgg ctggatatcg attgccttgt 2466661 ccagcatttc cagcgctttt tctcggtttt ctttataagc ataagtgaca ccggcattat 2466721 aaaatgcatc tgcatgcccc gggtcttgct ctgtcacagc tgcgaattgg ctgagcgctt 2466781 cgtccagcat gccctcgttg gctaagcaca tcccgaattg aaaacgcgct tccgtatcgt 2466841 tttcattcag ttcgactgct ctttgtaaat atggcagtgc aagcttaggc tgttcgagct 2466901 tgacaagtac cgttccgagc atgtaaaaca ggtcgccgtt ttccatcccc gcacgtagcg 2466961 ctttttcaaa catgtctttc gcttctttgt acatttcttt tacaacatag acatttcctg 2467021 ctccataata agcagtggct gcgctactgt ctaattcaag cgctttatca taaaacgcaa 2467081 gcgcacgttc cagctcgttt acggatgaaa gaaggttggc aaaattgata tacggaatcg 2467141 cgtcttcttt attttcttca atcgcttttg taaatgcctc tgccgctttc tcgtaatcgc 2467201 cttcctgcat cgcctctata ccgagttgat tataatccac cgatcatctt cctttcatta 2467261 aaaaacccca actcagtgtt gaggtttttc atcttttata cgtaccacaa ttttgttccg 2467321 tctttgtaca catcatcaat tgtcccgccg ccaaggcatt cttcgccgtc atagaagaca 2467381 acggcttgtc ccggcgttac agcgcggact tgttcatcaa agatgacttc cgcttcacct 2467441 tcgccagtca tgcgcactgt tactttatga tcctcttggc ggtaacggaa tttagccgtg 2467501 caggaaatct cttcgccctt catgatatcc gaacgtaccc agctgatatt tgttgctgtg 2467561 attttgtcgg aatataaaag cgggttatgg aacccttgat ctacgtagag gatgttcttt 2467621 tcaagatctt tgcctaccgc aaaccacggc tcgccgcttc cgccgatgcc aaggccgtga 2467681 cgctgtccga tcgtatagta catcaacccg tcgtggcggc cttttacttc gccgtccatc 2467741 gtcatcatat cgcccggctg tgcagggaga tattggctga gaaacgtttt gaagttgcgt 2467801 tcgccgataa agcagatgcc tgtactgtct tttttcgtcg ctgttgcaag ttctgcttct 2467861 ttggcaattt cacgcacacg gcttttttga agttcgccga tcgggaacat gactttgctc 2467921 agcgtatctt ctgtcagctg attcaggaag tacgtttgat ccttgttttc atcaatgccg 2467981 cgcagcattc tgacttttcc gccgcttctg tctactcttg catagtggcc agtcgctaaa 2468041 tagtcggcgc caagtgacaa tgcatgctcc aaaaaggcct tgaatttaat ttctttgttg 2468101 cacaatacat ccgggtttgg tgttctgcct gctttatatt catcaaggaa gtattgaaat 2468161 accttctcat aatattgctt ttcaaagttt acggcataat acggaattcc gatttggttg 2468221 cagacgcgga tcacatcttc ataatcctct gtcgccgtgc aaaaaccgtt ttcgtccgta 2468281 tcatcccagt ttttcataaa gattccgatt acatcatagc cctgttcttt taacagcagg 2468341 gccgccacag atgagtctac tccgccggac atgccgacga cgactcttgt atcctccggc 2468401 cgtttttcca tttcattcac tccaattact acgccgcctt attatgtcag ccgtttgaca 2468461 acgtcggcca catgtttggc agcagttttc acttgctcag ccgtattgcc gaggccgaag 2468521 ctgattcgaa tagaggacgt cagccggtca ctctcttcgc cgaacatagc agtcagaaca 2468581 tgtgacggca ggactgaacc ggccgtgcac gctgaaccgc tggagacagc gacaccagcc 2468641 atatcaagat taaccagcag cgcttccact gacacaccgg ggaaataaag attcagaaca 2468701 tgcggcagac tatgctcttt gtccccgttg acctcgaatg ccacacctgc atctctaagc 2468761 gtgtcggcaa agattgcttt aaacgattga tacttctcgt ttttttcgtc acgttcttca 2468821 cttgacagct tgatcgcttc tttcagcccg acaatgcctg gaacattttc cgttccggca 2468881 cggcgttttc tttcttgctc tcctccgaat aaaaggggtg aaagcttcac atctttacta 2468941 gcatataaaa agcctgtccc ttttggcccg ttgagcttgt gcccggaaac agacagaagg 2469001 tcaatatggc tgtttttcac atcaattggc agcaacccga atgcctgaac agcatcggta 2469061 tgaaaataag ctttgtgttc ctttaacagc tcaccgattt cttcgatcgg ctgcactgtt 2469121 ccgacttcat tatttccata catcactgtc acaaggattg tatcatcacg cagtgcttct 2469181 ttcacctgtt ttgcactgac tcttccattt tggtcaacgt ccagatacgt tatgtcaaat 2469241 ccgtctccct caagtttttc acatgtgtga agcacggcgt gatgctcaat ttttgttgtg 2469301 atgatatgtc tgccaagatc ttttcttgca agtgcggttc ccatgatcgc caagttatca 2469361 gcttccgttc ccccgcttgt aaaaatgatc tcctgctctg ccgctccgat ttctgctgcg 2469421 atctgcgctc ttgcttcatc cacccatttt cgagattctc tgccaaatga atgaatactg 2469481 gagggattac cgaaactgcc ggagaagtgc ggtatcattt gttccagcac gcgctcatcc 2469541 atcggagacg ttgcggcatg atctaaataa atccgttcca ttatgtttac acctctgatc 2469601 taaatataga acatataagc ttcttgctct ccgtctgtat agctggcaag atcctctaat 2469661 gttgtactgt ctaaaacctc ttttacagca tcccggatgc gaatccagag ctcacgcttg 2469721 gcaggctcct catcttccag cacttcaaca gggctgatcg gcccctcaag cacacggata 2469781 atatctcccg cagtaatggc atccggctca ctgcctaata catatccgcc atatgcgcct 2469841 ctgatgcttt tcactaaacc ggcatttctg agcggcgata ccagctgctc caaataatgc 2469901 tcggacaaat tattcgtctg tgcgatgctt tttaatgaag tcgggccttc accgtgcttt 2469961 tttgcaagct cgatcataat ggtgagcccg tatcttccct tagttgatat tttcaacatg 2470021 aacacctctg ttatttcatg attttccaca tttataatgg taatttctat atgtttcgtc 2470081 cgtttattat cttatagacc aactgttatt ataacatacc ttcagcgaat tttcattgag 2470141 gcagaaggaa aggggccttt acccttttct aatgtacggt tttccgttac cctgtaatta 2470201 agtaaggaga gatgatagat gaagccattg gcatatcgga tgcgtccgac aaaaatagag 2470261 gatattatcg gccagcagca tctggtggct gaagataaaa ttattggcag aatggtccag 2470321 gcaaaacatt tgtcatccat gattttgtac gggccgcccg gaattggaaa aacatcaatc 2470381 gcaacagcaa tcgccggttc aacaagtatt gcttttcgaa agctgaatgc tgtcattaac 2470441 aataaaaaag atatggaaat cgtagctcag gaagccaaga tgtccggcca agtgattttg 2470501 attctggatg aagtccacag gctggataaa ggaaaacagg attttctatt accctattta 2470561 gaaaacggaa tgatcatttt gatcggagca acgacggcta acccgtatca tgccattaat 2470621 ccggcgatca gaagccggac ccagattttt gagcttgaac cgttaacacc tgaactgatt 2470681 aaacaggcac tggaacgtgc gctccatgat gagcatcggg gccttggcac ctattctgta 2470741 tccattgatg atcaggcgat ggagcatttt gcccacggat gcggaggaga tgtccgctcc 2470801 gctttaaatg cgcttgagct tgccgtgttg tcaacgaagg agtcagcaga cggtgaaatt 2470861 cacattacat tagaaaccgc ggaagaatgc ttgcagaaaa aaagcttttc tcacgataaa 2470921 gatggtgacg cgcattatga tgtactgtcc gcttttcaaa aatcaatccg cggctctgat 2470981 gccaacgctg ctcttcacta tttggctaga ttaattgaag ccggtgatct ggagagcatc 2471041 gcaagacgat tgcttgttat cgcctatgag gatatcggtt tagcaagccc gcaagccggc 2471101 cctagagtgc tgaacgctat tcagaccgct gagcgagtcg ggtttcctga agcgcgaatc 2471161 ccgctggcca acgcagttat tgagctttgc ctctcaccga aatcaaactc tgccattctg 2471221 gcaatcgatg aggccctggc agatatcaga gccggaaaaa ttggggatgt cccgaagcat 2471281 ttaaaagacg cgcattataa aggagctcag gaattaggaa gaggaatcga ctataaatac 2471341 ccgcacaatt acgacaacgg ttgggtcgaa caacaatacc tccctgatcc tctgaaaaat 2471401 aagcaatact ataagccgaa acagactgga aagttcgaat ctgccttaaa gcaggtgtac 2471461 gataaattaa tgaaaagaaa ataaaacaaa aaaacagcct tgatcatcaa ggctgttttt 2471521 atgcattatt tatccttcac acgtttgatt tcaatgtctt tcaaaagatc catgacaaca 2471581 tgtccgccca taatcaaacc tgcaactgac ggcacaaaag cattagagga aggcggcatt 2471641 tttgctttac gtattttcgc ttcgtcattc cccacttctt ttctgacatc ttcccgaata 2471701 acaatcgggc tttcatcaga gaaaatcact tgaacgcctt ttttgatacc ctccttgcgt 2471761 aatttcgtac gaacgacctt cgcaattgga tcagtgtgcg tttttgagat atcagcgatt 2471821 tggaagcgtg tcggatccgt tttatttgca gcacccatgc tggagatgag cggaatatcc 2471881 cgttttagac attctttcat taaatgaatt ttataacaaa tggtgtctga cgcatcaatg 2471941 acatagtcaa gaccatagtc aaaaaactgc tcatacgttt cctccgtata gaacattttt 2472001 aacgcgatca cttcacactc cgggttaatg tctgcgatcc gcgccttcat taaatcaact 2472061 ttcggctgtc cgacagttga aagcagcgcg tgaagctgac gatttacatt tgtaatgtcg 2472121 acatcatctt tgtcgacaag cagaatgcgg ccgacgcctg accgcgcgag agcttccgcc 2472181 gcgaacgacc cgactccccc gactccaagc acagcaactg tgctgttttt cagcgtttca 2472241 aggccttctt ttccgatagc taattcattg cgtgaaaact ggtgtaacaa gaacctcact 2472301 ccacattcgt attctggttt catctataaa atggctgatc catgagcagc cgttttttct 2472361 gcgcacaaaa aataaagtcc caatagtgcc gttgcagctt tcctttgttt tgaacccgct 2472421 ctcagcaggt gggtgccctc ttttaaatct tgtaagtcct ctttaccgaa tgaaaagagg 2472481 catgtacgcc atttaaaaat gcgggctccc aaatcaaaaa aatgttcggt caaaactagg 2472541 tgtacaacta acacatcagg actttattta acttgtcaaa atcatatcac agacgatttt 2472601 gattttcaag aatcgaactg caaattcagt tcttaacttt tttcttgata gaaagatgaa 2472661 gctcgtcaag ctgggcgtcg cttacttcgc ctggcgcttc tgtcatcagg cagcttgcac 2472721 ttgccgtttt cgggaatgca atcgtatctc tcaggttcgt acgtccagcg agaagcataa 2472781 cgagacggtc taagccgagt gcgattccgc cgtgcggagg agcgccgtat tcaaatgctt 2472841 ccagcaggaa tccgaactgt tcagccgctt cttctggtga gaagccgaga agcgcaaaca 2472901 ttttttcctg aatatccttt tcgaaaatac ggattgaacc gccgccaagc tcatagccgt 2472961 ttaagacgag gtcataagct tgcgctttca tgtcttcagg cgctgtttca atcagctcaa 2473021 ggtcttctcg gacaggcatt gtgaacggat ggtgcgctgc gtaaaaacgg ccttcttccg 2473081 gatcatgctc taatagcggc cagtcgatga cccataagaa attgaacaat ttttcgtcaa 2473141 tcagtccgcg ttctttccca agctttaagc gcagggcgcc gagtgatgcg gccacaactt 2473201 cgaattgatc cgctccgaac agcagcaaat caccttcagc agcatcaagt gcttcaatca 2473261 gcttagactg cttttcttca tcaaagaatt tagcgatcgg gcctttcact ccgtctgcct 2473321 caaccttcac ccaggcaagc ccttttgccc cgtagtttgc agcaaaagcg ccaagagcgt 2473381 cgatgtcttt tctggagtaa tcgccggcac cgccttttac attgatggct ttgaccacgc 2473441 cgccgtttgc tacagctgat gagaacactt taaattccgt atcctttaca atgtcagaca 2473501 catccgtcaa aagcatgtca aaacgcgtat ccggtttatc agacccgtac ttgttcattg 2473561 cttcgtcata cgtcattcga ggaagaggaa gctgaagttc ctcacctttt gtttcacgca 2473621 taacctttgc catcatctcc tcagccaatg acataatgtc ttcctggctc ataaaggaca 2473681 tttcaatatc aatttgcgta aactcaggct gacggtccgc acgcaagtct tcatcgcgga 2473741 aacagcgggc aatttgataa tatcgttcaa tgcctgatac catcagaagc tgtttaaata 2473801 gctgcggaga ctgcggcagc gcgtagaact caccttcgtg cacacggctc ggcaccaagt 2473861 agtcacgtgc gccttcaggc gtgcttcctg ttaaaatcgg cgtttcaata tcaagaaacc 2473921 cattttcatc taaaaagctg cgaacagctt tcgtcacgtt atggcgcagc tgcatcgtct 2473981 ggaacatagc cggtctgcgc aaatctaagt aacggtgttt taaacgaacg tcctctgaca 2474041 cttcttcagc ttgatcagaa atcgcaaatg gaggtgtctt tgcagcattt aatacgttca 2474101 ctccatcagc atgtatttcg atcgcgcctg ttttcaaatt cggattaact gttccctctt 2474161 cacgcgccac cacttttcct tgaatatcaa gcacgtattc atttctgatg ccttccgcaa 2474221 tagcaagcgc ttcttttgac acatcagggt taaaaacgac ttgaacaatg cccgtacggt 2474281 cacgcaagtc aataaaaatc aatccgccga ggtctcgtct tttttggacc cagcctttca 2474341 gcgttacaga ttcgccaatt gctttttcag ttatatcacc gcaataatat gttcttccaa 2474401 acaatgcgtt tcactcctta tcccttttgg tttgccttca tcacatgtat aaattcatca 2474461 agtgccactt caatctgttc gcccgtctgt gcatccttta cattgatttt gttttgggca 2474521 agctcatctt cacccaaaat cgcaataaat ctggccttta agcgatcagc tgttttaaac 2474581 tggcctttca ttttcttatt ttcataatcg atttcactgg aaatgcctgc ttctctcagt 2474641 ttgtacacca atgaaacaga ataatccttt gctttttcgc cgagtgtgac gatatagcag 2474701 tcgattccct tatcaacagg cagctctctt ttttcagcat caattgcggc aagcaagcgt 2474761 tcgatgctca tcgcaaatcc gatgcccggt gcttcaggtc cgccgatctg ttcgacaagc 2474821 ccgtcgtagc gtccgccgcc ggcaagtgtc gtaatcgcgc caaagccctc cgcattgctc 2474881 ataatttcaa atgcggtgtg gttgtaataa tccagccctc tcacaaggtt cggatcgatt 2474941 tcatacgaaa tgccaagatc atttaagtat tgtttcactt tttcaaaata agcggctgat 2475001 tcttcattta aatatgtcaa aatcgaaggt gccgatttca tcagctcatg atcacggtct 2475061 tttttgcagt ccaaaattct aagcgggttc gtgtgcagcc gggactggca gtctgaacaa 2475121 aattcttcga tgcgaggctc gaagtgtttc acgagcgctt ctctgtagct tttgcggcta 2475181 tcttgatcgc cgagactgtt tatgacaagc ttaacgtttt ctaaacctgc tttttcataa 2475241 atactcatcg caagcgccat tacttcagcg tcgattgcag ggtctttcga accaatcgct 2475301 tcaattccaa actgataaaa ctggcggtaa cggcccgtct gaggacgttc ataacggaac 2475361 atcggcccga cataataaag ctttgtcggc tgtacaggat ttgcgaacag cttgttttca 2475421 ttaaaagcgc gaaccgcagc agctgttccc tccggacgaa gcgtcaggct tctgcctttg 2475481 cggtcctcga aggtatacat ttctttttgt acgatatccg ttgattctcc gacgcctctg 2475541 gcaaacagtt ctgtatgctc aaaaatcggt gtgcggattt ctttatattg ataagtgcgg 2475601 caagtgtctc tcataatttg ttcaacaaac tgccagcgat ctgattctcc aggcagaata 2475661 tcctgtgttc ctctcggaat gttatatccc ataggtagac ctccttatgt attccttata 2475721 aaatatccaa tgatcgttaa tgatgaaaat gaaaaaaact cccgccccta ctatacatga 2475781 tagtagggac gagagttata cccgtggtgc caccctagtt ggaatacgtt catattcccg 2475841 ctcgatcctt taacgcaggt tcacgttcac tgcctaatgg cgttattcac gcgttcagca 2475901 ggaaacctcc ggagtgttgt ttcgagaaag acgcaatggg atccgctttc agcctggggc 2475961 gggttcctct ctaatcatgc aatctgacct actcttctcc attattggtt caaatctttc 2476021 atcatttgct atgtactcaa tttctattat aataatggga ttggggttct ctgtcaagct 2476081 ttattccggt tgtttttcct cagcgctgct tctttggaca taagaccaaa ttcagatgct 2476141 gtttccgtaa gataaccagt cgtatcggga tctgcgtgat cgctgtaatg cagattcgct 2476201 tcaccgtcgt gaaatgcacg tcccattttt ggatgatatt tcatgatttg cacacctttt 2476261 tgattgtatt tacgcttagt ataaacaaat cattttattt ttatttaaaa atcagaaagg 2476321 actttacgat attaaacaag aatgcttttt taatgatcat cagaaaggag gacacaatga 2476381 acaagaaata ctttgtcctt attgtatgta ttattttcac ctcagcgcta ttcccgacct 2476441 tttcatccgt tacagctgct caaggagaag cggtcatcgc aacagatgaa atgaacgtca 2476501 gaagcggccc agggcttagc tacggcatta cagcggaagt aaaaaaggga gaacgctatc 2476561 caattttaaa ggaagatgga gactgggtgc agatacagct tggttctgga gaaaagggct 2476621 gggtagtctc ctggcttatt acaaaggaag accaggccag cacaagctcc tcaggaagca 2476681 gtgacactgt gacatcaaca gaccccgatc tgcggatgag aagcggcccg ggcacttcct 2476741 acgaagtcat cggcaaattc ccgcaaggca gccaagcatc tgtcattgat aaagattcgg 2476801 gctggatcaa gatatcctat cacagtgcca ccggatgggt atcatctgaa tatgtcacat 2476861 caggaggcag cagttcagcg tctgatgaga gtgaccaaac cgaggattcc ggtgcgtcaa 2476921 cgacgggcac agtcggtgtt tcttcgctaa atgtaagagc ctccgcctca catgacgcgg 2476981 caattataac aaaacttgat cgcggaacga aactgacggt tctcaacgag aaaaatggct 2477041 gggctcacat tgaggtgaac gggctaaaag gctgggttgc aagccattac cttttgacta 2477101 gttctgttcc agctgatgat tcagcaaatg ccggcagttc atcctccgct aaaaaagcct 2477161 atatcatgta cggaggaacg aatctaagaa gtgatgcgtc aacatcagct tcgatcgttg 2477221 agcgcgctgc caaaggagat tcatacacca ttaccggttc aaagggaagc tggtatgaaa 2477281 taaagcttga taacgggcag actgcttatg tagccaattg ggtggtccaa acgtctaaaa 2477341 gcgcagaaga agcaggtgaa ccgccagtct ctgattcccc gtctggaaac ggctctctaa 2477401 acaataaaac gattattgtt gacccgggac atggaggaaa agacagcgga acgatcgggt 2477461 attcggggaa attcgagaaa aacctgacga tcaaaacggc aaaactgctc gccagcaaac 2477521 ttagatcggc tggagcggat gtatatgtga cacgccagga tgataccttt gtcagcctgc 2477581 agtcacgggt ctctacctct cactaccgta acgctgacgc ctttatcagc attcattatg 2477641 acagctatgc ggatacctct acaagaggca gtacagcata ttactacagt cctgccaaag 2477701 atcaggaact cgcatcagat gtccactcag aagtggtgaa gcgttcttcc attccagacc 2477761 gcggcgtatt attcggagat tattatgtgc tccgggaaaa cagacagccc gctatgctgt 2477821 acgagctggg atatgtaagc catccgcagg aagaagccat tgtacatagc aattcatacc 2477881 aagaaaaagt aacagatggg atcgaaagcg gattagagaa atacttccaa taaaaaaagc 2477941 tgccttttgg cagctttttt tattttgaat ccataatgag cgtgaccggt ccggagtttg 2478001 taagctgaac atccatcatt gctccaaacg ttccggtctc cactttgatt cctttttcac 2478061 gaagcaggtc attccatttt tcataaagac ctaaagcttt atcaggtttg gccgcgttca 2478121 tgtagttcgg ccggcgccct tttttcgtat ctccataaag cgtaaactgt gagacggata 2478181 aaatctctcc tcctatatct acaagagaca gattcatttt cccttcactg tcatcgaaaa 2478241 tacggagatt gacaacttta tcggctaaat aagctgcatc atcttctgta tcatcgtgag 2478301 tgatgccgac cagcaccata aggccttgtc caatttggcc gacgacctct tcgtccactg 2478361 taacgcttgc ttctgttact cgctgaacaa ctaatctctt ttctaacccc tttagttcat 2478421 gacgcggcgc acagaataga tatctctaat ctgtttaata cgctcgacga ctttatgcaa 2478481 gtgattgata ttctggataa aaatcgccat atggatggtt gccactttat tgcgatccga 2478541 tttgccagag acagatgaaa tattggtttt cgtttcattc actgcctgga gtacctcgtt 2478601 cagcaatccg cggcggtcat acccaagaat ctctatctca acattgtatt ccttgcgctt 2478661 ttgaacttgt gactcatgtt cccactctac cgggatcagc cgctcttggg cttcattcgt 2478721 tttgacattc ggacagtctt cgcgatggac cgaaacccct ctgccttttg tgataaagcc 2478781 gacaatatca tcacctggca caggattgca gcattttgat aaacggacaa ggaggttgtc 2478841 aatgcccttg acacgaacgc cagcttcccg ttttcttcct tgcgggtatg gcttaggttc 2478901 cccagtgact tcctgaacga tcttttcctg ttcttcctgg tcgcgctgct ttctctcttt 2478961 ttctgttagg cggttcgcca cctgcagagc tgtgatgccg ttgtaaccga ccgccgcgta 2479021 catatcctct tcatttgaga aattaaattt gtcagcaacc ttttgaatat tctccggcgt 2479081 taaaacatcc ttcaattcaa aatccaagtt tttaatttct ttttcgacca gctcacggcc 2479141 tttttcgaca ttttcttcac gccgctgttt cttaaagaat tgacggattt tatgcttcgc 2479201 ttgggatgtt tgggcaagct tcacccaatc ctggctcgga ccgtaggaat gcttagaggt 2479261 gagaatttca acgatatcac ctgtccgaag cttatggtca agcgtaacca tttttccgtt 2479321 tactttggca ccgattgttt tattgccgat ttcagagtga atccggtaag aaaagtcaat 2479381 cggaacagaa ccggacggaa gctcgattac atctcctttt ggcgtaaaga catacaccat 2479441 gtcagagaac aaatcaattt tgagcgattc cataaattct tctgcatctg tcgattcatt 2479501 ttgaaattct aaaatttcac ggaaccaaga aagctttttc tcaaaggttg caccttcatt 2479561 ggctgctttc ccttctttat aagcccagtg agccgcaacc ccgtattccg ctatttcatg 2479621 catttcaaag gtgcggatct gcacttcaag cggatcgcct ttaggcccaa taaccgttgt 2479681 atgaagcgat tgatacatat tcggcttcgg cattgcgata taatctttga atctgcctgg 2479741 catcggtttc cagcatgtgt gaatgatgcc aagcaccgcg tagcagtcct ttatgctatt 2479801 cacaagaata cggacagcca acaaatcgta aatttcattg aattgcttat tttgcagcac 2479861 catttttcga taaatgctgt aaatatgttt cgggcgtccc gagaagtcag ccttgatatt 2479921 tacttcttcg acacgtttct tcacttcatt gacaacctca tcgacataaa gctctcgttc 2479981 tgcacgtttc ttcttcatga ggttgacaat tctgtaatat tgctgagggt tcaaataacg 2480041 gagcgccgta tcttccaatt cccacttaat ttttgaaatc ccgagacgat gcgccaaagg 2480101 agcaaaaatt tccagcgttt cattggagat tctccgctgt ttttcctgag gcagatgttt 2480161 cagtgtccgc atattgtgaa gacgatccgc cagcttgatc aatatgaccc tgatatcttg 2480221 agccatagcg acaaacattt tgcgatgatt ttccgcctgc tgttcctctt gagatttata 2480281 tttaattttg ccgagtttcg ttacgccgtc tacaagcatt gccacttctt cggaaaatgc 2480341 ttctttcagg tcatcgagcg tcacatctgt atcttccacg acatcgtgca aaaatccgcc 2480401 cgcgattgtg gaagggtcca tttcaagatc aacgagtatc cccgcaacct gaatcggatg 2480461 aataatatat ggctcgcccg atttgcggta ttgctcgcga tgagcatctt cagcgtacag 2480521 atatgctttt tcgacaaatg cgatatgctc atcagataga tagctgcgtg ctttatctat 2480581 aacttgctcg gcagtcaata cttgttcgtt cgccatggaa tcaccttttt taaaatgtaa 2480641 actgtattgt agtttattat caagaaaaaa acgaaagatg taaagagcag aagttcaaat 2480701 agccaaatat tatataaaat aaatgcaaaa caataggaaa aaagcaccct gacatggagt 2480761 gctttttcgt tatgcggtta tccttagtat ttcatcaatg ttaagatgtc gtaatcttcg 2480821 agcttatttc tgccgtcaag gtaagaaagc tcgattaaga aagcgatacc agcaacaacg 2480881 ccgccaagtt cttcaacaag tttgattgtc gcttcaattg tgccgcctgt cgcaagcagg 2480941 tcatctgtaa taagcacacg ctgaccaggc ttaatcgcat ctttgtggat cgttaatacg 2481001 tcttttccgt attccaagcc ataatccact ttgattactt cacgaggcaa cttgccttct 2481061 ttgcggaccg gcgcaaaacc tacgccaagc gcgtaagcaa cgggacagcc gataataaag 2481121 ccgcgcgctt cagggccaac gaccaaatca atttgctttt ctttcgcata ttcaacaatt 2481181 tgatctgtgg catagcggta tacatcgcct ttatccatca gtgtcgtaat atctttaaat 2481241 tgcacgccct ctttcgggta atccggtaca attgttacgt attgttttaa atccatctgt 2481301 tttatgtcct cctcgtactt tcataagcct ctgaatcttg tttcatcagc ttattcagcc 2481361 attccttcag ctcttcagca gaagaataat tcagcttttg atccagttcc atcagctgct 2481421 gtttcgcctg atatgtttgt gagtctgtta agtcgcgttt ctttgctccg ctcacaacag 2481481 acagcacacc attctctatt ttaacaaaac cgagatcaaa aaacaccttt gtcatgaaat 2481541 tgattgtttc aacggaccag cctttatgtt ttgcaagctc tgaaccgtgt tttttcacgt 2481601 caaaagcgcc tcttttcagc aagaacgcat aataccattt aaagtggtct cttgcgggaa 2481661 aagttgataa aaagtggtcc tcatgattga gaaaaataaa atatatccgc tcgggcgcct 2481721 ttccttccag caaacgtgcg agcatgtcca gcgaaggcgg cggatccagt aatacaatat 2481781 atgcaccatc gaggtcaaac gcctttgctt gatctttaga actgatgacg tgcacttctc 2481841 ggcgaaggtc ttcagtttga agtaatgttg ttgagtcttc tttgaaagag acaatggccc 2481901 gtttagcaga tggaagggcg gaaactgtgt cttcccacgt ccgttttccc cttaaatcaa 2481961 acagctgcca ttcagaaaca gcggcatcct ttatcataag ctgcggcttt tttcgattgt 2482021 tccattcgtt gattgacatc tcaccgacaa tggaaattct tgaacccggt acgatgcctt 2482081 cttgaagctc gcctttatta aaaccgacgc aatcaagctg ggacgactcg tttctgatcg 2482141 tcattttgac atgagtttta tttgccccta tcttgcggac atcttccagt actgcatttt 2482201 ctacgagaac gtgcggtttc gggttcagca tgccaaaagg agacagcatg ttcatttctg 2482261 cgatgctttc aactgtaatg tcttcgacgc cgcagacaag gtcgacttcc tgtacgggaa 2482321 taaaatcctc ttccgtaagc gtattgtccg ctatttcatt cagcctgctt cgcaaatccg 2482381 gcacatcttc ggctttcagc gtcatccccg cagccattgg atggccgccg aaatgaggaa 2482441 gaatatctct gcattcagaa aggctctcaa ataaattaaa tcctctgatg cttcgggccg 2482501 aacctttagc gattcccttt tcttcatcaa taccaagaac aatggccggt cggtagaaac 2482561 ggtccacaag ctttgaagcc acaatcccga cgactcccgg gttccatccg gctttggcca 2482621 cgacaattgc agtttgatcg agcccttgct gttcaaccat ttcaatcgct tcatccgtca 2482681 ttttgctgac cattttttgg cgctctttgt tcagctggtc aatttctgcg gcaagctctt 2482741 ccgcttcaaa cgaatcctct gacataagca aatgaacagc gggatccgcc tgttcgattc 2482801 ttccgacggc attcagcctt ggtgcgagct gaaatccgac tgtttcttcg ttcgcttctc 2482861 cgatgtctcc gcctgacagc ttaatcagct cttttaagcc gagccgattt gtccgtcgaa 2482921 gcctttcaag tcctagtgtt gctattaatc tgttttcgtc atgcagcggg actagatcgg 2482981 caatggtgcc gatagccgcc aggtcaagca gttcatcagg aagttcaccc aataaagcgt 2483041 gggcaagctt aaacgcgact ccaaccccgg caagctcttt aaacgggtaa gtgcagccag 2483101 gctgcttcgg gtggacgatc gcacggacat ccggaagctc cggtcccggt tcatgatgat 2483161 cggtaatgat gacatccagt ccgagttcct ttgccacctt cgcttcatgc acagcggcaa 2483221 ttcctgtatc aaccgtaatg atcaaagaga agccccgttc tttaatcgaa cgaaacgcct 2483281 gttcattagg tccatatcct tctttaaaac ggtcaggtat ataaaaatca acttgagccg 2483341 acagtttttg cagcgtgtga agcatcactg acgtacttgt aaccccatcg gcgtcataat 2483401 cgccatatat cataatcttt tcttgttgtg aaatcgcctg ttttattcga tctgccgctt 2483461 ctttcatgcc tttcatttca aaaggatcat aaaaatcggc atcctttgta tgtaaaaaca 2483521 gcctagcgct ttctgccgta tcaaagcctc tttttacaag cagggacgca acaagaggtg 2483581 ttatatgcaa ttgttctgtg agtgatttga ccttatcctg atctggtcgc tggatttccc 2483641 atcgcatttt tgacgctaac ataaattcac ccctcaacca ccctattata ctagagcagg 2483701 ctgaggggtt tcaaataata ttcgaaaact agtctttttt ctcaatcatg gctgatgcat 2483761 cctgtgtgtc agtctgatca gcaagatgag tatcctcttg tttatgtatt gctgttctat 2483821 tttctttccg caaggttttt atttcccgct tcaatttcat tacctgaaaa atgccgacag 2483881 aaaatacgat cagtgctccc attaaaactg agcccaaaat aacaagaatg agcggccatt 2483941 ctgatcttcc aaacaggtaa tcaacttcta cggatcgaac attaatgact gcgaaaatag 2484001 cgacaattaa ggtgaaaata agtgcgaaaa taatggtcca ttgtttattc attctctttt 2484061 cccccaaact tcttattgag gtaactttcc caatcaagac tggttttaaa catggcttaa 2484121 cactaggtta agctcccttt gctgttaatt tttcccggat cagcctcttc agtccggttc 2484181 cctcaccgga aatcacaagt gtatcgcctt cgtcaatgac tgtttcagag ctcggattca 2484241 gttgtttatc ctgattcttt ttaacaattg caatgaccgt cacatgatat tcctgaccca 2484301 cattcaaatc accaatcgtc tgatgaatgg caggcgctcc cgcctctgct ttacaccact 2484361 ctataatcaa atcatcaagg gctgactcga cctgttctaa tgctttcggt ttatatgcca 2484421 ttccgccaag aattgcagac atttgccttg cttcagcgtc atcaaactgc acggaggcaa 2484481 cacattcctc atggtcgttt tcgtcaaaat agtaaagctc tctccgtccg tcatgatgaa 2484541 tgataattga aattttatca cggtttctag taatcatttc aactttttgt cctatgcccg 2484601 gcagctctga ttcgcgaacc ctcatatata aaccctccta catatctgaa aaccagccat 2484661 aaacactttt aacaccatat atatgtttaa atgtaagcgt atgtcattat agcaaatgtc 2484721 tattttaagt tcaatgaaac ttcaaaaaac aggctgccct gcagaggaca gcctgatatt 2484781 ttttattgcg ccgaatcttt tttcagttct cttcctttcc atgcaagcca aatttgtgcg 2484841 gcaatgtata gagaagaata aacgcctgtt aacagcccga ccaataaagc aattgagaag 2484901 ttagtaatag aagatgctcc aaagatcagc aatgtcacaa caacaatcac aacggttaat 2484961 acagtgttaa ttgaacgtgt aaaggtttgc tgcaggctca ggtttacaat atggttcaga 2485021 tcggcaaagg ttttcggctt acgctttttc atatgctcgc ggaccctgtc aaatgtaacg 2485081 attgtatcgt taatggaata cccgattatc gtcaagatgg ccgcgatgaa tgtaacatct 2485141 acctcaagcc ttgtaatact gaagaacgtg acgataaaga atgcgtcata tagcaatgag 2485201 gcgatggcag caatcgccat tttgtattcg aatcggattg aaacgtaaat aatgatgcca 2485261 atagaagcta tagcaactgc gtacagcgca tttctcgcca gctccttacc gactgtcggt 2485321 gaaactgtgc tgacatttgg atcagatccg tatttgtctt taaaatacgt ttttactttt 2485381 gcaatggttt ctttatctgg caccccgaca aaacgggcaa caccgatatt gctcttttcg 2485441 cctgacagaa ctacagtatc agggtccata cccagagatt caaaatcctt ctcaacttgc 2485501 tctgtcgtca gcttatggtc gctttgcact tcaatccgtg caccgcttgc aaagtcaatg 2485561 ccaagattca gcctgaacac aagcaggata ataatcccgg caaccgtgac cgcactggag 2485621 aaaataaaga agtatttgcg tttgctcgtg aaatcccatt tttggaatgg cgtatgcggc 2485681 tctgtatttt catccgtatc ctgaatatcc atgatatgtt tcttattgac accaaaccag 2485741 ccttttttcc gatcaagcca tctgctttcc acaaggagag cgaggagaaa tctcgataag 2485801 aaaacggcag tgataaagct tgtcaaaatc gataggatca gcattgtcgc aaacccttta 2485861 acagagcttg tcccaaagat aaagagcaca accgctgcaa taatggttgt aatattcgcg 2485921 tcaaaaatcg tcgcaaatga ccgtctgttt cctgaacgga aggcagagcg gactgacttt 2485981 cctagcttga gctcttcttt aatccgctca taggtaataa tgttggcgtc aacagccatc 2486041 ccgacaccta aaatgagagc ggcaattccc ggaagcgtga gtacggcatt catccagtca 2486101 aagatctgga gtgtaatgta gatataaaca gacagcgtaa tcaccgcgat taatcccggc 2486161 agacggtaat agaaaagcat aaataagaaa ataattgcga taccgacaat accggcaaac 2486221 accgtatcat ggagagcctg ctggccgaat tgcgcgccta ctgatgtcga atacttttca 2486281 gtcagtttca caggaagtgc gcctgcgttt aaaatgctgg ctaaatcttt cgcttcttga 2486341 gctgtgaaat gaccttcaat ttttacatca gttgtattta gttcctgact tacatttgga 2486401 gcggatacaa atttaggatg ctctttttga acttctttct taaaggaatc acctttatca 2486461 taatccaacc aaatgacaag ctggttgttt ggcgccattt tcatgacctt cttggtcact 2486521 tcaccaaatt tatcagcgtc tttcagctta atcgtgacaa ttggctcatt tgttgtgcta 2486581 tcataagttt gtttagcgcc gttttcgact agatcagcac cgtttaacag ttccttatca 2486641 tttgcatctc tgaaagaaag ctgcgcttca gtcgccaaaa tttcacgcgc tctgttttgg 2486701 tttgtcacgc cagcgagctg aacgcgaatc cggttattcc cttcaatttg gatgttcggt 2486761 tcgctgacac cgagaacatt ggcccggcgg ttcagtgcct ctactgtgct gaccagaacg 2486821 tcttttgtga ttttgtcacc tttttttaca ggctgtacat catacagcac ctcaaatccg 2486881 ccttgcaaat ccaatcctaa cgtaatattg ttagcggcag gcttcgtaaa gtagcccaag 2486941 cccgtgccga tcaatagaac gaaaaggaaa aacgcaatca agcgtccttt tttcattatg 2487001 tatatcctcc cttaaacctg tgcgaatcaa cctgctatct cagcagttct tccaatgctt 2487061 cctggccctc ttcactgccc agccaattag acgttttaaa tgactcaacg gttgcatagt 2487121 tcataaattc gccaattttc actgataaaa tatcactcgc cagttcataa atgctcagtt 2487181 ccgttttctt tttccacttc ttatctgtta agtatgacca caaactttcg agttcaacat 2487241 catcataccc gagaatctta aactcttcca gtttgctgta aagaaacggc ctgacgtggt 2487301 ctttatatag atcggctgga tgcttctcca cgaattccac gctccttttt tattgttttt 2487361 caagaagact tgtcatgctt ggacgacata tacgcatatc tttattgtat atgattccag 2487421 gtagtttgag aaggcagggg gtaaaaatgg cgaaacagac gtttttaaag ggcactctta 2487481 tccttatcgc agcaggaatg gttacaagaa tgctcgggtt tgtcaaccgg gtggttatcg 2487541 cccgttttat cggtgaagaa ggagtcgggc tttacatgat ggcagcgcct actttcttct 2487601 tggccactac attaactcaa ttcggtctgc cggtcgcgat cagcaagcta gtcgctgaag 2487661 ccagtgcgcg cggagatcat caaaaaacga aaaatatttt agtcatgtct ctgaccatta 2487721 cgggagtgct cagcctcatc tttacaccgc tgtttctgtt tttcgcccct gttatggctg 2487781 aaacgatgct gacagataag cgaacactgt atccgctctt ggccattacg cctgttgtgc 2487841 cgattattgc tatatcgagt gtgctgaggg gatactttca aggaaaacag aatatgaacc 2487901 cgcttgctat gtcacaagtc cttgaacagg ttgtccgcat ttcactcgtg gctgtctgca 2487961 caacgatttt tctcccttac ggaattgaat atgctgcagc gggggcaatg ctatcctcag 2488021 tggcagggga gctggcatca cttctttatt tattcgtttg ctttaagtat aaaaagacaa 2488081 ttaaaatcag aaagcatttt ttacagtcaa ttaaaaacgg aaaacaaacc tttacccaat 2488141 taatgagcgt gtcccttcca acaaccggga gccgctttat cggaaacctc tcttggtttt 2488201 tcgagccaat cgtcgtcgct caaagccttg ccatcgccgg tgtggcaaca gttgccgcaa 2488261 caaagcaata cggggaacta accggctttg ccatgacgct gctgactctg cccagcttta 2488321 ttacatattc tttgtcgacc gcgcttgttc ctgcgatcag tgaaggaatg gagcagaaaa 2488381 aattgcaggt ggtggaatac cgcttagaac aggcgatgcg tctctgtctg ctcagcggag 2488441 gcatttcagt tgttatttta tttgtatttg cggatgagct gatgagagtg atgtacggtt 2488501 cctcaggcgc agctgtattt ataaaagtga tggccccgtt ttttctgctt tattatttcc 2488561 aaggcccgct tcaagctgtg ctgcaggcgc ttaatttggc aggagctgcg atgatgaaca 2488621 gcttaatcgg agcgcttgtc aaaacaggcc ttatttttgt ccttgccaca aggccttctc 2488681 ttggcattat gggcgcggca ttagccattg tgacaggcat ggtgctcgtc acgctattgc 2488741 acgcagcaac cgtaagcaaa gtgctgccga tcagcatcaa aatcaaggag tacgcgctca 2488801 gcttcgctgt tattgtaatt tgcggattca tcagctccgc catcaaacaa tatataagct 2488861 ttggagcatc tgaggctgtc aatctagccg gatggattgc ggcgagcgcc gccatttata 2488921 tgatcctcct gctcgttttc cgtttaatta aaaaagatga gcttcgccgc attcccatta 2488981 tcggacggtt gatcatccga taatggtcac gtgcggtgcc catctttttc atcaatatat 2489041 atttctccgt ctgtaaacga gcaaaatgaa atatctgaag ggtttgtgta tccgtgtttt 2489101 tgcaaacttt caagcagcca ttttctatct ttactgattc tggacaggtt ttctgtttga 2489161 atgaagccgt ctataatgag cggcatttcg agctgccgat gctctccgct gttttctttc 2489221 ttaacaatag tcagtttgcc cgacggctct aaaatagcaa atgatacgtc agctactctg 2489281 tcgatgctat tttctctgag ctgaaccatt aaatcatcaa aattataacg ctgtgatttc 2489341 atggcttctt cgtcaatttt tccatatttg ataattatgg tcggcttacc gtcaagaagc 2489401 tggcggactt ttcggttttt taaagaaaag tatgccaaag tcacttgaat gatcattaat 2489461 acaagcattg gcaaaatggt atgaaataga tgatcgtcta cgttttctat ggctaaaacg 2489521 gcaatttcag ccatcatgat aaagacaacg agatctaaaa tactaagctc tccgatctcc 2489581 cgtttgccca tgaaacgaaa aatgaccaat atcacaaaat acaatacgac tgtgcgaaac 2489641 gcaatagtga gaagctcttc cattatgcac ctccaactca ttataggttg caacaaaatg 2489701 atcaatttat gtaagaaaaa ccgattgcat ttcacaaagc ttttacgtct aattcatggg 2489761 ataagggaat acatttttac aaagacgagc catcagcatg tctgacggtt ttgaacaaaa 2489821 agaacagaag ccttttaata caggcagaga ggagacaatc atggaggaaa cgaaacaagt 2489881 tggaaaaggc attctttacg gcttaatcgc catattttca gccatgctcc tgacaagttt 2489941 agcggtttca cttttattga ccgcaacctc gctggaagaa tcatcattta actggctgat 2490001 caccgctatc tcatttctct ctttatttat cggcgggttc atttcaggcg ggaaaggcaa 2490061 ggaaagaggc tggatgattg gcgcattgac cgccttaagt ttttctctga ttatcttatt 2490121 gtttcagtat ttaggattcg gaaagacatt tacagcagaa cagctgatct tccatctggg 2490181 atttttaggg gtgtgcatgc tgggcgggat tttcggcgtg aacatgaggg gaaacaggtc 2490241 ttccacataa aaaagagcgg gctcacttgc ccgctctttt ttgtttgcta tgtatagctc 2490301 ctgctgttat tcagcagcag aaacttctct gatcgcgcgg cggtcgaacg taagacgtgt 2490361 gttatcacca gtcttaatta cgactttgct ttcgtcgata gagtcaacag taccgtgcaa 2490421 tcccccgatt gtcactactg aatcgccttt tttcagttcc tcttgcattt ggcgtacagc 2490481 cttttgctgc ttttgctgag gacgaatcag caagaagtaa aggaccgcaa acattaaaat 2490541 aataggaacc aatgtaccta aagtgccagt catcattttc acccctttct gtaagcctgt 2490601 tatgtttatt tagaagcttt tcgcatttgg cttgttatag ccgtaacgct caaagaactc 2490661 ttctctgaaa tcacccagac gatcctcgcg aatagcctgt cttacctgct ccattaagtg 2490721 taacagaaaa tgaaggttat ggtaagttgt taatcgaagg ccgaatgttt cattgcagcg 2490781 aatcaagtgc ctaatgtacg cgcgagtgta gtttttacat gtatagcaat cacactcttc 2490841 atcaatcgga cggaagtctc tttcaaattt cgcatttttc atattgagtc gtccttcagc 2490901 agtaaacact gtgccgtttc ttgcaatccg tgtaggcagc acacagtcaa acatatcgac 2490961 cccgcggatc gctccgtcga tcagtgcgtc cggagaacct actcccatca gatatctcgg 2491021 tttatccttc ggcaagagcg gtgttgtgaa ttcgagtaca cggttcatga catccttcgg 2491081 ttcacctaca gacaatccgc ctatagcata tcccggaaaa tcaagcgaaa tcaagtcctt 2491141 cgcactttgt gtccgcagat cttcatattc tccgccttgt acaataccaa acagcccttg 2491201 ttcatcctga cgattgtggg cattcaggca gcgttccgcc cagcggcttg tccgttcaac 2491261 tgacctcttc atgtagtcgt actccgccgg gtatggcggg cattcgtcaa acgccatcat 2491321 aatatcagag ccgagtgcgt tttggatctc catcgctttt tccggagata aaaacagctt 2491381 gtctccattt agatgattgc ggaaatggac accctcttcc tctatattac gaaacttgct 2491441 taaagaaaag acctgaaaac cgcctgaatc tgttaaaatt gcgcggtccc agttcataaa 2491501 tttatggagc ccgcccgctt ctttgacaat gtcttggccc ggacgaagcc atagatgata 2491561 agtgttgctc aaaatgatgc ctgcatccat tgctttcagc tcttcaggcg acattgtttt 2491621 gactgtcgcc agtgtgccga ccggcataaa aaccggcgtt tcgaaggagc cgtgaggcgt 2491681 atgcactttg cccagccgcg ctcctgtttg tttgcattct tttataaatt catagcgtat 2491741 tggttgttca gccacttttg atgaggcctc ctgttctcaa attatataat cagcatcgcg 2491801 tctccgaagc tgaagaaacg gtattcctct tccactgcat ggttataggc acgcagaatg 2491861 ttttctcttc cagcaagcgc gctgaccagc ataatcaatg acgatttcgg caaatggaag 2491921 tttgtaatca ttccgtcaat ggctttaaat tcatagcccg gataaataaa aatagatgtc 2491981 cagccgcttg atgctttaaa ttgcccgtca tgttctccgg caatcgtctc aagcgtgcgt 2492041 gtcgaggtcg tgccgacaga aatgatccga ccgccatttt ctcttacttt gtttaaggct 2492101 gcagccgttt cttctgacat ttgataaaac tctgcatgca tattatgctc ttccacttca 2492161 tcggcactca cagggcgaaa cgttccaagg cctacgtgca gtgtgatgaa ctcaatttgc 2492221 acgcctttgt ctttcagctg ctgtaagatt tcttccgtga agtgaaggcc agctgtaggc 2492281 gcagcagcag agccaatttc ttttgaatac actgtctggt agcgctcttt gtcatcaagc 2492341 tgttctttga tatatggagg gagcggcatc tctccaaggg attcaagcac ctcgtagaaa 2492401 ataccgtcat attgaaattc catctttctg ccgccgtgct caagctcttc cgtgcagatt 2492461 gccttcaatc ttccgtctcc aaatgtgaca acagttcctt ttttcacccg tttcgccggt 2492521 ttggcaagtg tttcccattt atcaccggtt tcctgtttca acaaaagaag ttccactttc 2492581 gcgccggtat cctcttttgt gccgaataac cgcgcaggca gtacccgggt attgttcagg 2492641 actagacaat cgccttcgtt aaagaagctg ataatgtgtt taaacgagct gtcagtaagc 2492701 tctcctgtat gtttatcgag caccatcagc cttgaagcat cacgctgctc caacggtact 2492761 tgtgcaatta aacgttctgg tagttcaaaa tcaaataaat cgactttcat gatgatttca 2492821 cctttattct agtcttttgt tatttcattc tgccaaaaag attaagcaaa attgataata 2492881 ccacacttat aataatacaa gtgacaaccg ggaagaaaaa cgtaacattt ccttttttta 2492941 caaaaatatc tcccggcatc ttgccgacaa aatgcaaaac tgctccgata ataagcaaaa 2493001 cagcaccaag aatcataatg atcttaggaa attcagtcat atcggggagc ctccatttgg 2493061 aaatgatgat aaacggccgg tgtcacgatc cttccacgcg gcgttctttg tataaatcca 2493121 atttgcagca gatatggttc atatacgtct tcaatcgtat gcgattcctc gccgatggta 2493181 gctgaaatcg tatcaaggcc tactgggccg ccgttgaatt tttcgatcat gcccatcagc 2493241 agcttatgat caatatgatc caaaccgagg cggtcaacct gaagccgctc cagcgcattc 2493301 tgagaaatgt cttccgtaat cctgctgtca cccagcactt gggcgaaatc gcgcaccctt 2493361 ctcagcaggc ggttcgccac gcggggcgtc cctctcgatc ttcttgcaat ttcaagagcc 2493421 gacggtttat caatctcaac ctcgaataca tcagcggttc ttgtgacaat atccgccagt 2493481 tcttcttgtg tatagtactc aaggcgagac attacgccga atctgtctct taaaggagcc 2493541 gtcaaaagcc ccaccctcgt cgtggctccc accagcgtaa aaggcggaag gtcgaggcga 2493601 accgagcggg cagatgggcc tttgccaatc acaatgtcca ggcaaaagtc ttccattgca 2493661 ggataaagca cctcttcgat cgatctgtgc agcctatgta tttcatcaat aaataataca 2493721 tctcccggtt ccagcgccgt taatatagca gccaaatcac caggcctttc aatcgcaggc 2493781 cctgatgtcg tccgcaattc cactcccatt tcattagcaa caatcgaagc aagcgttgtt 2493841 tttccgagtc cgggcggccc gtacagaaga acatgatcca gcgtctcctg tctcattttc 2493901 gccgcatcta taaacacgcg caaattttct tttaccttat gctgcccgat atactgtgcc 2493961 agattttgcg gcctcaggct ttgctctatc actgattcat ggttgtctgc ttcacttgag 2494021 acgagccgtt catccatgaa catcacctta ctttaatagt ttttgtaatg cttttttcac 2494081 atattggtct gttgtcagcc caatttcttc tttaaggtga ggaagcacct ttttgatttc 2494141 tttttcagca tatccgagaa ccctgagggc ttcaagtgct tcttcaagag ccgtttccgc 2494201 tgtttgcttt tcaagccttt cttcatgatt aaacagattt tcaatcattt caggcacaac 2494261 atctgccagc tttcctttta aatctagaat aatctggcgt gcggttttct ttcctactcc 2494321 aggaaacttg accaaaaaag cttcatcttc attttcaatt gcttggatga ccgctccggg 2494381 atcacccgag cccaagatgg caagtgctcc tttcgggcca attccggtca cgtttaacag 2494441 ctttgtaaag agcgccttct cctctcttgt tgaaaaacca taaagcgaaa aagcatcctc 2494501 tctgatatga tggtatgtaa aaatcgtttc ttggcttctc tccttatata taaacggatt 2494561 cggcgtgaaa atctgatagc cgatgccgcc gttctctatg acaatatatt ggggagatac 2494621 ataatcaatc gtccctttaa caaattcaat cacgcaaatt cacctctttg actgttcttc 2494681 attgtaccat aaaaacagcc aaagtcttat agaaaagtta acatatgttc gcttctctct 2494741 cattctttca cgaaaaaaaa gacatgaata catgtcttca atcagcggac gctacccgct 2494801 gtatgtcttc atatgttcga tgacatcctc aaactccgct tttgtccgaa atggaatgcc 2494861 tttcagcaga tttttttgca tatggctttc cagcctttct aaatcaattt gaaaaaaaga 2494921 ctgaattggt tcggaagctg gctcaggccg cccatgaaaa gtggaaatca ctccattatc 2494981 cgatacaccg atatacccgt tgaccttgct gagcggagaa atatcgtcca tttgcttccg 2495041 gaagagcaca tatccctttt tttgttccac tagcgtccat ccggcataag ctgcccaaaa 2495101 atcatccata gaaaacactt tttcatgctt atgctcaatg ctgacatcgc cgtccaaata 2495161 caccttttca agctgcacat gcacctgcag cggctcatag tgctccactt ccgcgccaag 2495221 tgcgcgggaa ggagctccta ttaaaaatac tgccgctgag caaagaatgc ccagcaaaag 2495281 atacgccgtg ctgaatcgtt tcaccctcta cacctctttg cacacgttta tgattagttt 2495341 gaccaaagag gctactgctt aaccgtttta tcaaaatttg tctgcacatt ttccctgaca 2495401 aaccgttcct ccgtatacac atctgtgctt tgctcagaaa ttgtcaagaa tcgcgtcaga 2495461 aaggcactga aaaaatacaa tgccgcaaag atccaaatca cgccacctgc accgagcggc 2495521 ccaatgaaaa gactcacgat gcccggcgcg ataaacgcac ataaaccaga tcccaaattc 2495581 aacactgaca tggcagcacc tttattatca ggtgcaagcg tcggcaaaag cgcgcttaat 2495641 gggacgtacc ctgctaaagc cgcgccgtag cagcaggcga taatcatgag cacccaatac 2495701 tgatgcccga tcagctgagg cgtgtaatac agcgccagcg taaaaatacc gcatccgaca 2495761 ccgccaaacc acatgaccgt attgcgccag cctagtttat ctccgactgc accgaaaatg 2495821 atattaaaca caatattcac aaaaaacagc gtcccccata tttgcagcca ttccgaaacc 2495881 gaatacccgt atcgtgctaa ataagtagga agaaagatgg caaatccaaa ttgtcctatc 2495941 gcattaatcg tcttgaccac tccgccgatg cctaccttag ggttttcaaa cataatcgta 2496001 aatgccttcg acagttcttt ccatttcggc tgatcttgtt tttgtatcgg agtaaattta 2496061 tctttgttaa aaaataaggc aagaattccg cctgccgcca caaacagtaa agcgctccaa 2496121 agcgtattga tttctccaaa ggccggaact gcatagctgg aatagaacgg accgagcacg 2496181 ttaaggccgc acgtaaacat aaaccaaaac cagccgacgg cttttccaag aatattttga 2496241 gaggtgctgt atgacaccca tacgagaaaa gagtatgcaa acagcggata tcccaagcct 2496301 ctaagagcat agctgcccaa gagagccgga taatacatat gaggaatcgc ccagccgata 2496361 aaagcggccg aaccgaggat aaatgcaagc aatccgacag tcatcgtttt tctcggcccc 2496421 caagtttgga caaacgttcc tgaaagccaa gctgagatgg tgacagcaat gccgtacatg 2496481 gtaaataacg atgcggattg ctgcatactg agaccatgat caacgagaaa aggagacagc 2496541 cagccttgtt cgaggccgtc tccaaccata aagatgacaa cgccaatata accccaaacc 2496601 atgtgagaag gaattccgat tttgttcaaa acatttcctt tagcatgtac tgtattcatt 2496661 ttctccaccg cctacttaaa gtatcaatgg agtatatacc caagcttgct gaattgtaat 2496721 cctgttagat taaaaagcga ttttttcagt gtgctcaatg ctaacaggca tgccaaaagc 2496781 aagcgattgc tgtgctgctc tggcgatcct cccggcctgt aaaccgtcat tgccggtgca 2496841 gggagtctcc tggtttgtgc cgatcgcttc tgcaaaacgg agaatctcct cctcatatga 2496901 atccttatag cgttcaagga aaaagaaatg cggtttatcc ttcatcacaa aatcagctgt 2496961 tgacacctca accgttgtcg gcctgctatt gtcagccgct gcagagcctt tcgtcccgaa 2497021 aacctcaacc cgctggtcat atccgtacac agcttggcgg ctgttatcaa tcacagccat 2497081 ggcaccgttt tcaaaagtca gtgtaataac agctgtatca atatcaccca gctccgcaaa 2497141 agaaggattc accaaagccg cccctttggc atacacttcc gtcacttcgc ttcccataat 2497201 atatctggcc atatcaaaat catggatcga catatccata aacaatccgc ctgacgtacg 2497261 gacataatct atattcgggg gttctgggtc ccgggacgtg atttttaata aatgaggtgt 2497321 accgatttca ccattttcaa caatcgtttt gattttctta aaatgaggat caaagcggcg 2497381 gttaaatccg acttgaagtg ttaccccgtg tttccggaca gccgcaagcg cttcactcgt 2497441 ttcgtccaga gagaaactaa cgggcttctc acaaaatata tgctttttcg cctcggctgc 2497501 ttctttgatc atctgtgcat gtacggctgt aggagagcaa ataaaaatag catcaatatc 2497561 aggatcatgt aataaatcac gataatcaga ggttatgtat tcaatctgat gactgtcggc 2497621 ccagcttttt atacggctcg cctgaatgtc agagattgct tttattttca tgtgaggaat 2497681 ccggcttata ttttgaacat gaagtttgcc gatgcggcct gcaccgataa tccctgtcac 2497741 aatctgtttt gtcatggctt cttccccctt gatcattcac gaaagcgctt tatttaaaat 2497801 taatactatc ccatttgtaa gcgcttttca agaatggaaa ttaaacgttc tatgtctctt 2497861 ttatcacaat tcatgcttat aagtagcctt cttcttcaag accagataca ctagaattag 2497921 gctctttttc ctgaacagtt tatgattttc ctataaacag ctgcataaaa tagagcaaag 2497981 aaggtgaatg aaatgctgac aaaagcagag gcactggccc ataccgtcat ataccgcaag 2498041 aacagcagat ttgataaagt caaagagaaa tccgaggaat taacactaat cggcaaggga 2498101 agaagcgcct atgtgtttgc cttaacagaa ggcggtcgaa aaatggcgct gaaagtattt 2498161 tttccggaat atcaagcgac agcagtcaaa gaagcagcga tctatgaaaa attagccggg 2498221 tccgcattct atcctgacat ttacgaaact ggcgattcat ttattctcat ggaatatatt 2498281 aaaggtgaaa ccttttataa ctgtctgaag aaaggcattg caatcagtga tgacatgatt 2498341 cagcaggttg aagaagcgct ttctgacgcc cgggcagccg gactgaaccc gtcagatatt 2498401 catttgcgga atctgatatt gacagaaacc ggggcggtgc gggtgattga tgttgcgaga 2498461 tttgagcaga caaaaacatg cacgcagtgg gacgacttaa aatccgcata tcatgcactc 2498521 tacaaaaaac cgatattccc caaaaagatt ccgggttttt ggctggagat catcgcattt 2498581 ttatataaga aagattggtt tcaaaagcat ttcgcacagc ggaaaagaaa atattcttaa 2498641 atcaaaaagg cagccgcaca agcggctgcc tttatcatgt attttttact ttctgacggc 2498701 agaaatcagt ttcatttgtt caggcgacag cttaattcga tagcctctca cagttaagta 2498761 gaccgcttct gggtccttct cgccggaatg acaatacgtt ttttccattt ctgtctcccc 2498821 tcacccttta ttggctttat ttcatcttat cattgcttta ttgaggtaat tttaaagaaa 2498881 tgtaaagatt atatgaatcc gatatatagt aaaatgagag aaaaaaaggg agagagtcac 2498941 attaagaccg aaaacacctt gagcttagat gcagccagag gtgaacttgt aaatgaaaaa 2499001 acacttgtca agagaacaat ctactggaat tacccggaca gccgcccagc agtgacgtgg 2499061 atcaatcaca atacagtgaa aatcggcaat cagactttac atcttgatac tgatgaaacg 2499121 tatgattggc gaaaagatga tcattggatc cgtgaagaac cgccgcaggc gtcagtgagg 2499181 tgatgaaaca tgaataagat gaacggaaca aatgatgaaa agcatttcaa tcattttgtg 2499241 attgctttat cctttatata cggtttgact gaactaggct atttgttgct gaaggatttt 2499301 ataacaattg ccataagttt gcctctgtag aaaaacgcag cgtagtcgat acgccgcgtt 2499361 ttttcttttt cccttcctct tcttattgat aattacaggt catataatgt gacaaatcga 2499421 ttgtagaaat agttcgatta gaccaaaatc ctttttatac atgtattcga atttgaagtg 2499481 agggggaagc ttgatggcag attttgttgc tagtttgaat gcggtcttat ggagtacgcc 2499541 cgtcatttat attttattgg gaattggatt cgccttttca attatgaccc gttttttaca 2499601 agtccgacat ttaaaagaaa tgattgttca gatgttcaaa ggcaagagct ctgaagccgg 2499661 cgtttcatct ttccaagcgt tatcgattgc gctgtccggc cgtgtgggca caggaaacat 2499721 cgcgggagtg gcgacagcaa ttgcattcgg cggacccggt gcagtgttct ggatgtgggc 2499781 gattgccttt atcggggcgg cgagtgcctt tgtagaatca acgcttgctc aaatttacaa 2499841 agtgaaacaa gacggtcaat atcggggcgg ccctgcttat tatatagaaa aaggcttagg 2499901 cattaagtgg tttgccgtct tatttgccgc tgctgccctt attgcaatgg cctttctaat 2499961 gccgggcgta cagtccaact ccattgcggc tgggatccaa aatgcattcg gcatctctcc 2500021 tttcgtcaca gggtgcggtc tggttttatt attagggttc attatttttg gcggcgtcaa 2500081 acgaattgcc aatgcggcgc aaatgattgt tccatttatg gccattggat atatcctgct 2500141 gtctttgatt attattgtca tgaatgtgtc tgaattgcct gctgtgatct cattaatatt 2500201 caaaagcgcc ttcgcattgg attccgcttt tggcggcttg atcggtatgg cgatttcctg 2500261 gggcgttaaa cgtggcattt actcaaacga agccggccag ggaacaggcc cgcatccggc 2500321 agctgctgca gaggtttctc atccggtcaa gcagggactg gttcaggcat tttctgttta 2500381 tattgacacc ttgtttgtat gttccgctac agctttcatg atcttgttta ccggcatgta 2500441 caatacccag gctgcagatg gttcctttat cgttcaccag cttaaaggcg tagaagcagg 2500501 acctggtttc acacaagcgg caattgacag tgttcttccc ggattcggtg caggctttgt 2500561 tgccatcgct ttattcttct tcgcttttac aacaattatg gcgtattact acatcgcaga 2500621 aacaaatatc gcctatttag cacgaggcag agaaagcaaa tgggcgatgc ttggcttaaa 2500681 actgattatt ttagccgcca cgttctatgg tactgtgaaa acagcttcac ttgcttgggc 2500741 attaggggat gcagggcttg gcattatggt atggctgaac gtcattgcca ttgtgctgct 2500801 tgccaagccg gcgctccttg ctttaaagga ttatgagcgc caaaagaagc agggcttaga 2500861 cccgatcttt gatccaaaag cgctgggtat caaaaacgct gatttctggg agaaagaata 2500921 cactcatgaa agtgaacgtg tctcctgaac atactaaaac cggcccgata tgacctcgtg 2500981 ccggtttttt atgaacgata gtttgtatac acttcttgaa catcatcgtc atcttcaagg 2501041 acgtctatta atgtttccag cttctcaaca gcctgatcat cggcttctgc ataggtattg 2501101 ggaagcatgg tcacctccgc cgaagaaatt agatatttcg attcgagggc tgttttcacc 2501161 tcttcaaaat gctcaggctc tgtgaaaacc tcatataggt cttcttcaat tcgcagctct 2501221 tctcctcctg cttcaagcac atcaagcatg agctcatctt cttctatttg ccgttcagta 2501281 cggtctatcg taatgaaccc ctttcgttca aataaaaagg ctacacatcc gctttctccc 2501341 agacttccgc catttttatt aaaggctgtc cgcacatttg acgccgttcg gtttttatta 2501401 tctgttacgc attcaaccat gacggcaatc cctgaagggc cgtagccttc ataggtgatt 2501461 tcttcatagc tgcttccgtc ttggcctccc gcagcttttt taatggcccg atctatattt 2501521 tcattcggca tattggcgcc ttttgctttt tcgatgacaa gacgcaatgc tgaatttgct 2501581 tctggatccg ctccgccttc tttcgctgcc acatagattt cttttgccag cttcataaat 2501641 attttcccgc gctttgcatc ctgtgcattt tttctttttt gaatgttttt ccacttggaa 2501701 tggcctgcca tgttttcacc ttcttttaca ttttctatgt acactttaat gggaaatgtt 2501761 cgctgatgca aagaaaaagg ctgccgaata tcacttccgg cagcccttcc ttcctagcgg 2501821 ttgttcattt tatgaagttt tctgaacagc cctttatctg ttgatacttg gacgtcacgg 2501881 ccatttgcat agttgcgcgc tgcttttaca acattatctc tgtcagactt tgtgaactct 2501941 ctgtggcttt tgactgcgat aactactcgg tcatccgata ccataacttg tgtgtcattg 2502001 acgtttttca cttgtttcac acggttggca atttttgcag ccagtcttct gttttcttgg 2502061 ttgtcatacc cgttgttcgc tgcattccga ttcatgtttc ggttattcgt gttgttatat 2502121 gttccgtcag ttgccaaagg aacacgatcg tcagcagtaa cacggtcacg gttatttaca 2502181 ttcgtggtgt ttcggttacc gtcgttctga tcctccatta attcagaaac aggaccatcg 2502241 tggtcgattc cgtctccctg tctatcggcg tcattttcat ttgtataata tccgattgga 2502301 cgggtattgc cgttattgcg cgtatcattc atagcattat cgtttgctcc gcatgctgtt 2502361 aagccggctg tcattagaat caggctagcg atcgtcattt ttttacccaa tggaaaaacc 2502421 ccccgtggac gaattgagca tgtttgctcg cttttatcat gtgcgtatgg ggggcatgtt 2502481 aagcgtgtca gttctctcca tttggcagtg atctgcttga aaacaaaaaa aggaacgatt 2502541 tacatcgttc cgaacgatca ctcattttct tcttccggac ggccaaacat ttggtttaca 2502601 gaaggctggt tcgtcattgg catagaaact cctgccgaat atgggtttgg atttgggtta 2502661 gctgtgccat atggcatatt agggcttcca taagctccca ttcccgaatg gccaggtgca 2502721 gagaaatatg gctgatgatc accgtcacag ccgcagtcgt catgatcttt gtatggcatg 2502781 taaccatgag ccgcagcagg ctggtatgct cccattactt ggggagtgcc gtaataaggg 2502841 ccatacggca tatgtccata cggagatcca taagccggag atgcgtattg cggcgcaccg 2502901 tatgaaccgt aatgtccgtg atggctgttt tcatgatgct ggttttcata acccgggtca 2502961 tactgaggcg atacaaagcc tggctggtat ccatgcatcg gatgcattgg ataagcttgt 2503021 gccggatagt acggatagca taatcctgat cctggaagaa ttggcgaaac aggcaccgga 2503081 cacggtacga aatgagccgg ataatgataa taaggctgaa cagccggcat cggcatattc 2503141 ggaactgtgt gatgaacgtt ttcctcttct ataccgccta cctctggcgc ctttggcata 2503201 ttaggcatat tcggataatt tgcattttcc atattactca tagcctcctg ttgtggaaat 2503261 tggtcttgca tatgatacat atgatccata tttccgtcat gatgtttttt cggctcctcc 2503321 ggtttaggag gcgaccaagg ctggaaaagc tgtttcatat cataataatc gttcacatca 2503381 gcttcagggt acacattttc ctgcaaatta ggcatcggcg ggacatacgg catggacttc 2503441 ttttctttcg gctttgtgtc ttctacatcg acaacggatt taggcttctc tttcgcatat 2503501 ggatgttctt gcttcacact cccggccgca ggacttttgc ccgcttttgg ctcttttctg 2503561 accgggactc cttctgacgg cacttttatt ttcattccag gcatgattaa gtctggattg 2503621 ctaagctgtg tattgagttt tttcacttcc tcaacatcga ctccgtactt ttcagctatt 2503681 ttccagagcg aatcgccttt ttgaacgata tggattttca acgttttccc ctcctatgca 2503741 aaacgtgaac agttcagctg tgattacaat atgtttcttc acaacatatg cctgaacaaa 2503801 agaagttatg agtaaaggaa gggaaaatat ttctgatcta cgtgatcgaa agcattcgat 2503861 tcagggcaag gagtgcatct tcctgaatgg cttttggcac cttgatgacg cctgaaggtt 2503921 ctcctttttc aatttgttcc agcgaccaca acaaatgcgg caaatcaatt cggttcattg 2503981 tcaggcaagg gcacatgtca gggttgagtg attcgatttg tttatctgga tgctcgtgaa 2504041 tgatccgctg aacaagattc atttctgtcc cgattgccca cttgcttccc gccggagcct 2504101 ggttgattgt gtcgataata tatttcgttg atccgttatc atcgcttagt gtcacgactt 2504161 cgtgtgaaca ttccgggtgc acaatgatct gaatgtcggg gtctcgctct ctcatatcat 2504221 ggatattttt agtggtgaat ttctcgtgaa cagagcaatg ccctttccac aaaatcactt 2504281 tcacattcgt atgcccggat tcagctacta attcatcttt catcggatcc cacacagcca 2504341 tatcttcaag cgcaatgccc agatcataag ccgtatttct ccctaaatgc tgatcaggca 2504401 aaaataaaat tctttttttc tgtgtaaacg cccattcaag cacttttttc gcattcgaag 2504461 aagttacagt tgctccgcca tgctttccga cgaatgcctt gatctccgca gtggagttca 2504521 cataagttaa aggtatgatc gtatctccaa atatatgctg aagcttcttc catgccctat 2504581 tggtctgctg catgtcagcc atgtcagcca tagaacatcc agctctcata tctggcagga 2504641 cgaccgtttg ctgctcgctt gtcagcatat cggcggtttc tgccataaag tgaacgccgc 2504701 aaaatacgat ataatccgct tctttgtttt tttccgctac ttgggccaat tgcagggagt 2504761 cgcctgtttg gtcagcaaat tgtatcactt catccttttg ataatgatgg cctggtataa 2504821 agagcctgct gccgaacttt ttcttaatgg cggcaacgcg cgtttccata tcctttctcg 2504881 atagttcttt ataactttcg ggcatcatat cattcgattg tttgatcaca tcaagaattg 2504941 acataacagc attcctccac agattcattt gataacgtaa catccatgct gatatctaaa 2505001 cttttgacgg aatgagtcag aaatcctaat gaaatataat tcacacccgt ccctttaaaa 2505061 gcaggcaaag attctaacgt aatcccgcca gaggcttcag tttttatatt agccggtgtg 2505121 agctttgcaa aatgacggac cgtatcaggc ggacagttgt caaacataat aacatccgct 2505181 ccagctgcaa ttgcttcccg cagctgttcc tccgtttcaa tttccacctc gatatttacc 2505241 atgtgccctg cggcctgacg ggcttttttg cacgcctcta aaatagagcc gcatgctgcg 2505301 atatgattat ctttaatcat gatgccgtca tacaaaccga atcgatgatt atacccgccg 2505361 ccggctctga cagcatattt ctccagcatt ctgagccccg gtgttgtttt tctcgtgtca 2505421 caaattttaa tctgttcatc atccagacac cgaacagcct ctcttgtcat tgtcgcaatt 2505481 cctgacagcc tctgaataag atttaatacg acccgctctc ctgaaaggag cgcagctgcg 2505541 ggaccgtgta actcggcaat cacttcacct ttatgcaaca tgtccccatc ttttttgtgt 2505601 aaaatgcttt gaacattttc gtccaataac gaaaagcctt cttttatgat cgctgctcct 2505661 gcaaaaatac cctctgactt tgcaacaatc tccgcttcac agctctgttc tccaaaaata 2505721 gactgcgatg taagatcccc tgtcccaata tcctcaagaa aaaagtgatt cagtaatttt 2505781 ttcagctgta aatgattcat tgttccaaat cccctcgttt tttctgatct tcgttccttt 2505841 ttttgtatgg acaatttgtc ttccttgcca gctcacctca gcatgaggaa aatcggtgcg 2505901 gaagtgagcc cctctgcttt cctcccgcaa aagcgcagaa aacgtcatca gctttgcagt 2505961 ttgccataga tgagaaagtt ccatctgccg aattgtgata tccttcacat ttacttcctg 2506021 aaaaggcagc gtatgaagcc agatgctaag ctcaatcaaa ctgctttgtt cccgcagaat 2506081 agacatgtgg cttgtcattt tgctttgcag ttcatgcccc tctatatccg gcacctcgta 2506141 gaagacactg gtttctagcc ctgattgata ttgcctgtta taaaccggtt tttggataat 2506201 atgctctgct gccctttttc caaataccag cgcttccaat aaagaattgc ttgcaagccg 2506261 gtttgctcca tgtaaaccgg agcatgctgt ctcgccaatc gcataaagcc ccggcactgt 2506321 cgtttctccc cagcgattaa ctgaaacacc tcccattaag aaatgcattc ccggagcaac 2506381 aggaattttt ccgctgtgga tatcaatccc tgctttttca caaatagcgg tgatggtagg 2506441 gaaacgcgtt tcaaaatcag aaatcgcact gaagtctata taaacgcgat ttccttttgc 2506501 catttcttcg tgaataaccc gtgagacaat atctcttgga gccaggtcac ctaaaggatg 2506561 ccgttcagcc ataatcctgc ggccgttttc gtctactaaa catccgcctt cccctctgac 2506621 agcttctgaa acaagcccgt aggaaacacc atttttcaca agcagtgtcg ggtgaaactg 2506681 agtaaactcc aaatccgtta attccgcccc ggcccggtaa gccagagaaa gaccgtcacc 2506741 tgtgacagtg agatcattcg tatggtgaag aaacaggttt ccacagccgc cggcagccag 2506801 cacaacttcg tctgcgtgcc ttaccttgag ccgccctttg ctgtcttttg tcatgacgcc 2506861 gatacatcgt ccgtcctcta taagcaaatc tgctgccgtt tcattctcga ttaacttgat 2506921 tttgctgttg atccgtttga gcaaataatc gataagcagc ctgcctgttg cgtctccgcc 2506981 tgcatgaaat atgcggttgt atgagtgggc cccttctctt ccaagacaaa caccgcctcg 2507041 ttcattgcgg tcgaatggaa atccacgctc caataggctt tgaaccatca tttttccatc 2507101 atgtaatacg tctgctacaa tagctagatt attatggccg caccctgcgt ataacgtatc 2507161 ctccagatgg gcttcaatcg agtcatcttt tgcataggcc gcagcaatcc cgccttgtgc 2507221 atagacagaa ttgctgtttt tgacgctttt ttttgtgata acagtcactt cgtatgaggg 2507281 cgggaaagct gcagctaagg aaagtgccgc cgcccctgaa ccgatgactg caatcgtctt 2507341 tttagacata tgccatcctc ctgttgttta cacctgtctt gacacctata tttacacaag 2507401 gataaaataa actcaagagt tttttatgga gaacggatgg aggaagaccg gatgatttat 2507461 ttagattatg cagcgacaac gcctatttgt gaggaagccc ttactgtata tcagaagctt 2507521 agtatggata tgtacggaaa tgccagcagc ctgcatgatg caggaggaaa agcaaagcac 2507581 atactggagt actgccgtga aaaaatcgcc aacatcattg gcggagaagc aagcggcatc 2507641 tattttacaa gcggcggcac tgaatccaat tttctggcca ttcaatcatt gttaaacggc 2507701 ctgccaaaaa cgaaaagaca ttttattacg actgccatgg agcatcagtc cattcataat 2507761 tgcgctgctt ttttggaaca gcagggatat gatgtaacag tcattgaacc gaatgaatac 2507821 gggcttatta ccgaggaaat attactaacc catatccggc cggaaacagg ccttgtatct 2507881 attcagcatg caaattctga aaccgggatc attcagccca ttcaacacct gtcttcatac 2507941 ctgcacaata aggggattct tcttcattgc gacgctgttc aaacgtttgg aaagatcccg 2508001 atcaatacaa aaaatctggg agtagatgca ctctcaatgt ccagccataa aatccacggt 2508061 cctaaaggag taggggcggt ctatatccgg ccggatgtcc cttggaaacc cgtttatcct 2508121 ctgactactc acgaatacgg attcagagcc ggcaccgtaa atgttcccgg gatcggtgcc 2508181 ttcactgccg ctgcagaatt gatcgtaagc gaaatggaaa aacagatatc ccgcaatgag 2508241 gcattaagaa catactttct agaccaaatc cgtattcggt ctctccctgt aacccttgca 2508301 gcagacactt cgaaagcaga atgtcttccg catattatag ggtgtttttt tcactcattt 2508361 gaaggacaat atgttatgtt agaatgtaat cggagtaata tttgcatttc aaccggcagc 2508421 gcttgttctg caggttacca cggtccgtct gaaacaatga aagcattaag aaaaaccgaa 2508481 caagaagctc tgcaatttat ccgcatctct tttggcaggc atacaacagc tgaacagctg 2508541 gaacagttat tacatacgtt tacagtgctt tgggaacaaa agaaaggaga atttgatatt 2508601 gaccgaagaa ttaaagctaa tgggcgccaa caggcgtgac cagcttcttc tgtggctgaa 2508661 ggaatctaaa tcaccgctga caggaggaga actcgcaaaa aaagcgaacg tctcaagaca 2508721 ggttattgta caggatatat cgctcttgaa agcgaaaaat gtaccgatta tcgccacaag 2508781 ccaaggatat gtatacatgg atgcagccgc tcagcagcac cagcaggcag aaagaatcat 2508841 agcatgtctg cacggtcctg aacggacaga agaggaactg cagctcatcg tcgacgaagg 2508901 cgttacagta aaagacgtaa aaatcgagca tcccgtatac ggagatttaa ctgcagccat 2508961 ccaagtaggc acccggaaag aagttagcca tttcatcaaa aaaatcaatt ctacgaatgc 2509021 tgcctactta tcacagctga ccgacggcgt gcacctgcat acactgacag cacctgatga 2509081 acatcgcatc gatcaagcct gccaagccct cgaagaagcc ggcattttaa ttaaagacta 2509141 aaaaaagccc tctagtgggc tttttttata attggtaaga ctggtatgca cccagaagcc 2509201 tcactttgca gccgagtgct tcaagctcct gcatggcccc tggaatcaat acatcatcaa 2509261 acgctttctc aatatcaata ataaagaaat aatggcctaa tccggtttta gtcggacgtg 2509321 actcaatttt tgacaggttt aaatttctcc aagaaaatgc agacagcact ctatgcagcg 2509381 ccccggactg atcatcctgc ggcagcatga ccattaaggt cgttttgggc ctagagctca 2509441 attttgaatt cacttcaaaa gatatgtttt catcgggaga caggataaca aatcttgtat 2509501 gattgtccct ataatcctgt atatcccgtt tcacgatttt taattcgtat gtagaagctg 2509561 ccatatcatt ggcaatgacc ccgatattca gctcgggatg gtcactgaca aactttgctg 2509621 ccgccccggt agaattggcg tattcatatg gaacggaagg aaaatgtcga tgaagaaatt 2509681 tatggcattg cgcaatcgcg tgtgaatgtg agtaaatttt gtcgagctct ttccatgcat 2509741 tctctcttga gggatggacg agcaagtgct ggtgaatcgg caacgtcatt tcacccacga 2509801 ttggcaaagg ctgttcatgt attaaatagt ctattgttag attaacagat ccttctaaag 2509861 cattttccaa aggaacaaaa gcaaaatcaa cttcgcctgc aacggctgca tctatacact 2509921 ccggaatggt gcggtaagca acatgttcgg cgccgttttg aaaacaagaa ctgactgcta 2509981 gatgtgtaaa tgtagctgct ggacctaaat aaccgacttt catgacgatt ttctctccct 2510041 tatgcacctg aacctaatat ttcaaccttt tctacaaaat caaacttcct gagcttattc 2510101 attaatgtat gaatgtcttc ttccattgcc gacgtactga tagacagtgt cacatttgct 2510161 ctgccttgaa gcggaatggt ctggtgaatg gaaagaacgt tgcttccaga atcagctacc 2510221 gcctgaagaa gctgagataa cgcacctgac ctatcctcca aatgaaagaa aagtgtgata 2510281 atttgttctt ttaccatggt gtagaatgga aaaacagcat ccctgtattt ataaaacgca 2510341 cttctactta aatcgacctt ttgaacggca tctgctactg aatctgcttt ttttcgatca 2510401 agcagctttt tgacttctaa tgtttttctc attgcatcgg gcaatacatc ttcacggaca 2510461 agataaaatg tctcctcttt catttgcatc ccccctttaa aatagagagc ctggcaccag 2510521 gctctctttt cagccaacat tgattaatca ataaattcaa attcaaattc cagaagcctg 2510581 attatatctc catccttggc tccgcgttct ctgagtgctt catcaacacc cattccgcgc 2510641 atctgtcttg caaaccgttt aaccgattca tcacgtgaga aatcagtcat cttgaataac 2510701 cgctcaaggc tgtctcctga aagcacaaat acaccgtctg gatcgcgtgt aatgttaaat 2510761 ggcacttctt cattttccat cgtgtacatg acacggtttt gtgtaagctc ttcctcgtca 2510821 tacagcggga attccggtgt gttctcaagc tgattggcaa cctcaaacag aagctcacgc 2510881 agaccttctc ttgtcaccgc actgatcggg aataccggat aatcatccgt cagcttttct 2510941 ttaaaggctt cgagattttc cgcagcctcc ggcatgtcca ttttatttgc aacgataatt 2511001 tgcggacgct cagtgagacg cagattgtac tcgctcagct cctggttaat cgtaagataa 2511061 tcatcatatg gatcacggcc ttctaagcct gacatgtcaa tgacatgaac aataaccctc 2511121 gtccgttcaa tatggcgcaa aaactggtgg cccagtccga cgccttggtg tgcgccttca 2511181 atcagccctg gcaaatcagc catgacaaag ctgcgtccgt catccgtttc aaccatgccg 2511241 agattcggga caagcgttgt aaagtgatag tccgcaattt tcggttttgc agatgagaca 2511301 acagacagca aagtagattt tcccacactc gggaacccga caagtccgac atctgcaagc 2511361 acttttaatt caagaacaat gtagcgttct tttcccggct cgccgttttc tgaaagctga 2511421 ggcgcgggat tagccggtgt agcaaagcgg ctatttcctc ttccgcctct tccgcctctt 2511481 gcaatgacag cccgctgtcc gtgctctgtt aaatcagcga tgacctgttt tgtatcatcg 2511541 tctgtcacaa cggtgcccgg cggaacttta atgaccatat catcagcatt tcgcccgtgc 2511601 tggtttttgg acatgccatg ctcgccgcga atcgctttaa agtgtttttt gtatctaaaa 2511661 tccatcaggg tgcggagacc ttcatctact tcaaaaacga cgtctcctcc ctttcctccg 2511721 tcaccgccgg cagggccgcc tttcggcaca tatttttcac ggcgaaacgc aaccataccg 2511781 ttgccgccgt cgccgccttt tacatatact ttgacctgat ctacaaacat aatgtcctcc 2511841 gttctaaacc gttaaaaact ccgctagtcc aacccaattt caatcagaca ttcgtgactc 2511901 gtgatttcaa aacgcatgat atcaacgtcc tcatatccat tctgccgaat atcatcaaaa 2511961 gcagatggat cggcaaaggc gccgtgaaaa tcaaggtaca gaatcagctg tctgtcagga 2512021 tgatccgttt gaagcgaaac cgttaaatga ttttcactct ctctgctgac tgcttgatca 2512081 aacagatgaa acagctttct catcagtttc gccagctttt gatcataagc cgacaaatcc 2512141 ttaatttctc cgagaacttc atattcaagc gtcatataat gggttttcca attaaacgta 2512201 agaaaatcaa acgccaaatg cggtgttttc aggtttgaga gctttgattc gtgctttgcg 2512261 tctataacca tttcttcaat catttcaaag acacggtcat acttctgtaa gcttaagttt 2512321 cctttaatca gctgcagctt attcatccaa tcatgccggg aatggccaag cagatgaatc 2512381 agttcgtttg ttaatgccgt gtcgcttata ttttcttctt gattttttga aacatccttc 2512441 attttcgcac tcccaatcat ttaatttctt atttaggagt ctgtataagt gtgtattatg 2512501 aattataaca gagaaggctt tgttagaaaa acaattgttt ttcccagaaa tatcatgttc 2512561 cttttttctg gctttggttg atttgcagcc aggcagaaca ttttatgtat tactgcttgg 2512621 ggaacatatc cagtgggttt gagatgttta ttctcattct tggcggggtc tgctcgcaca 2512681 tactctgcat ttcattctag gtgtttactc cgcatattgc aaaaaaaact ccagtcatca 2512741 tcgaccggag ttttttgaat cattattgag ctacaggata tacgctcact tttttgcggt 2512801 cacggccgaa acgttcgaat ttaacagttc cgtcgatttt cgcaaataga gtgtcatctc 2512861 cgccgcggcc cacgttttca cctgggtaaa tttttgttcc gcgttgacgg taaaggatag 2512921 aaccgcctgt tacgaattga ccgtcagcac gtttagcacc taaacgttta gcctcagagt 2512981 cacgtccgtt ctttgtagaa cctactcctt ttttagaagc gaaaaactga agatctaatc 2513041 taagcatgta gctcacctcc tatattatgt ttgtggtcac acgcaagttg tctttgtaat 2513101 cccgttcgat tgtctccagc gaaacaatca tgccttcaat cagcagctga gctttttggc 2513161 gtgcctctgg atcaagagat tcagggaatt caaaataaaa ataacccccg tcctctccta 2513221 tatcaagaag cggctcgaag cccgcgagca caatgaccgc gttaacggcc ccaaacacaa 2513281 cggctgtcac tccggcacaa acaagatctt gtccatgttc agcaaaattc gcatggcccg 2513341 tcatttcaaa agacaatatg cctttatcat gagaccttct gattgttgcc tgaatcatgc 2513401 ttacgcgttg attttttcga tcgtcacttt agtgtaaggc tgacgatgac cttgtttttt 2513461 atgaacgttt ttctttggtt tgtatctgaa aacagtgatt tttttcgcgc ggccttgttt 2513521 ttcaacttta gccgttactg ttgcgccttc aactgtaggg ttgccgactt tcacgttgtc 2513581 tccgccaaca aacaaaacgt cttcaaaagt aactgtttca cctgcttcag cagcaagttt 2513641 ttcgatgtaa acagtttggc cttcttcaac tttgatttgt ttaccgcctg ttttaatgat 2513701 tgcgtacatt ctctgcacct cctattagac taagactcgc cagataccag ggggctgtaa 2513761 aagctcttaa cacctgtact gagcggttgt agcaatggtg ctacatccat aacattaaaa 2513821 aatataccaa aatacaaggc gtttgtcaat cagttttagt agggcagaag cagttcctcc 2513881 atggaagaat tcgtccgctt atcggcaaag taagcgtgca gcacttcatt ctcgtcaagc 2513941 tggctgagct tttggcctga tttttctata ataatcggat gcttacagcc acgtttgaac 2514001 tcggccatca catgatagac tttatcctcc gcctttactg tcagcggcag aagtttctca 2514061 agctccctgt tttttccgta atacctttcg aggagaaatc tcacatggat atagtgcctt 2514121 tgccgatatt cctcaaacaa ggaaacagcc agaaagacaa acaaaaccca tgcgctgatt 2514181 tgcagaggaa tcacgaataa aacccagcac ccgagcagca ggcagaagca gagcgacgtt 2514241 tttagattaa gccggtgagc cttttgaaaa ggcagctgtt tggaaaacaa caaaaataac 2514301 agttttcctc catccagcgg ccagatcggc agtaaattga caaataagat agaaagatta 2514361 taaaaggtga agagttcaaa ggtatgctga tgaatcactg agacttctgc aagcatccag 2514421 gcggcaaact gaagccagat gtgctgaaga ggtccggcaa taatgaccgc aaactcttcc 2514481 tttaacggcc gattcccgtg ctcttccact tcgaccgttc cgccaaacgg cagcaaaaaa 2514541 acacgcttga ttctccaaga aaaaaacaca gccagagcag catgccccag ctcatgaatc 2514601 aatacaatca ggagcagaca taataatgct ttcatatggc ctgtgagcaa gcccagcgcc 2514661 gcaataatcc aaagaaaagg atgcacatgg atctttaaga taaggtcgag ccatttattc 2514721 aaatgaaatc acctgaatcg gatcaataaa tttatcgccg tctttcatgg caaaataata 2514781 gaccccttta ttatgatcat caagcttaat cgaaccgagc tttttgcctt tatccacaaa 2514841 atcatataaa gcaacatcca catctttgag ctcgccatag atactatagg tgttgtcagc 2514901 atgctgcacc ttaaccgtca gtcccgtttg gctgtctttg ctgacttcaa ccacatagcc 2514961 ttcttttacg ctatcaatct tatcactgct tgtttcgact ttaattcctt ccccattgtc 2515021 ctgaaaatcc tgctgtactt tcccggatgc aggcgcgatc agatctttgc ctacttcaat 2515081 ctgctgttcc ttatttttgt gttcaggagc caggaaagca agcggatttc cgaatttggt 2515141 ttcgaaccaa tggcttgctg aagcaaattg aaattcagtt tcaaaggttt tggctacggc 2515201 gggtttaatc tgactgacgg gtccaatgtt tgttttatag gctatagctg aaacgagaac 2515261 aaggcaggcc gacagaagac atttcaggat aattgaatct gttttcacca atgggtgttt 2515321 tccgttgaat gttggcatgt tatcttcgta gaccggaagt gttccatgct tttcctgatc 2515381 cgttaccatc acccaggacg ggggtttctg cttttcagaa actgtctgag tagagaaacg 2515441 ttttgagccg gaaagctgct ttcttctttt ctctaatcgt tttctgattt catctgctct 2515501 gtgactcatt gccatcatcc tttgcattcg ttgggtttgt acatcatatg tcttgtccat 2515561 ggcaaatatt cggtttagtc aagaacaaag caggcaaaaa caaaaaaaac ctgacacagc 2515621 atatgctttg tcagattctt ctctttgatt ctatcacatt aagatcttac tccgaaaaat 2515681 gacttaatct tagccatcat tcctttgttt tgctcttcaa gcacctgtaa aggaacagat 2515741 tcacctaaga tgcggcgggc aatattgcga tatgcaatgg aagcgcggtt tttagggtcc 2515801 atcgcaatcg gttcgccatg attggaagct ttaatgactt catcatcatc agccacgatt 2515861 ccgagcaaat cgatcgacag atgctgtacg atttcgtcga tatccatcgt gtcaccgttt 2515921 ttcatcaggt gatttctgat tctgttaaca acgagccgcg gcggttcaat attttcctct 2515981 tgctccagca gtcctataat acggtcagca tcacgaacag ctgagatttc aggcgtagtg 2516041 accacaatcg ctttatcagc tccggaaacg gcatttttgt acccttgctc gattccggca 2516101 ggacagtcta tgatgacata gtcaaattcc tgtttgagct cttggaccat gtttttaatt 2516161 tgttcaggag caacagctgt cttatcgctc gtttgagcag cgggcattaa atagagcaga 2516221 tcatcgaaac gtttgtcttt tacgagcgcc tgatgcattt tgcatctgcc ctctacaacg 2516281 tctaccagat cgtaaataat tctattttca agacccatta caacatcaag gttgcgcagt 2516341 cctatatcag tatctactaa gcatacgcgc ttccctaaaa tggctaaggc ggtaccgagg 2516401 ttcgcagatg ttgttgtctt acctactccg ccttttcccg aagttattac gatagcctca 2516461 cccaattcac attcctccct caagccttgt tagatcaggt cttaaatgag ccaaatgttg 2516521 aaggcgttca atgaccatat ttccgtctgt atctaaataa gcacattcca tttcgttccc 2516581 tttttgaatg tggtctgggg agcgatttaa cacatgattg attcttaatt gtgtcggaag 2516641 catttcagag gcggcgatga ccgcttgatt atttccattg aatccagcat gcgcaattcc 2516701 tttcagtgag cccagaacaa aaatgttccc tccggccctg actgttccgc cgggattcac 2516761 gtcaccgatc aggagcaagt cgccttttac ctgcagcact tggcctgaac ggacaatttt 2516821 tgaaacagaa ataatttcgg cttcctctct tatctgctgt gcttcttttt tagtaatgac 2516881 ttcactgtca atagaatgaa caaacaaatc tttctttgac gcaatcaatt cggttagctg 2516941 ttcctcttgc tccttatata aaaagcgatt tcccagctta acatgaacgc tgattttctg 2517001 gccttttcca tcggtatatt gttcaattga cagcatattc tgaagaccat cgagaagctc 2517061 atcaaaagaa cacgcatcat ccagatgcaa tgttagtcca ttctttgttc cttttattgt 2517121 tacatattgc tgctttttgg tcttcacaat attcacctca acaacatact catttcgtca 2517181 aaaaaagata aaatcctttt tactcatctc tcaattcttt ctttagactc ataaaaaaca 2517241 atctaaatgg cagaacaaga ataagagctg ctgcaatatt taataaaatt gtcggtataa 2517301 accggtcaag cacaaatccg ttaaacgtca taatgtcttt atgaatcaaa gactgaatgc 2517361 cgaatacgta aaattcgagc agacagacag ccagaactgc tatcaatatc actacaaatg 2517421 cgtttgtatg caacacttta aacgcttttg aagccaaata gcatagccct gcaaaaccaa 2517481 acatgtaaac gcctaataga cttgtatagt tcatgtcata tagaaagcca aaaataaatc 2517541 cgtaaatcat cgcgtgtttt tggttgataa aagccgacat gaatatcaat acaagcatca 2517601 aaaaacgcgg ggcgagcact tggtcatctg taacgaaagg aaaatgcacc aaatctgtaa 2517661 aaatgctttc cgcagaaaaa acaagcatca taacgaaagg gagaaggaaa cgtttcacga 2517721 tccttcctcc tctgtatcga cagtcggcac gtcacggtta acaacgatca cattatttaa 2517781 atctgtaagg tcagccgcag gttttacata agcaaccttc gttaatccat aggaatctga 2517841 ctcgatatca gtcacttcac cgattgtcag cccttctggg aaaacaccgc ctgtccctga 2517901 tgtttcaata agatcgcctt ttttcacgtc ttgtttatcc ttacgctcaa taattgtcat 2517961 cttaagacgt tttttctctt tgtcatatcc ttcgatcaag ccgtagcctt tgctgccttt 2518021 ttttccggaa atttttgtcg cgactctgtt attgcggtca gtatcgctta aaagctgaac 2518081 agcagacgta aaattgttaa gtccggagct tttgatcttg ccgattaatg cgcctttttc 2518141 gtttgtaacg gccatatctt tcgctacgtt ttgctgagtc cccttgttaa tggtgacctg 2518201 tttcgcccaa ttatcagggc ttctggcgat gaccgttgct aaaatcggct tgtaatcttt 2518261 aatcgatttg acatggccaa gctcgtcacg caaggatttg ttttcttctt caagctcttg 2518321 aagcttggct tcatattgtg tctgtccgtc aagtttttct cttagacgct cgttttcttt 2518381 gtatgtgttt tttaaatcat tgatgttctc aaatattcct gcaaaaaatt cggcaggcgt 2518441 atgaaaaata ttttgaaata ctcccgtcgt atcgccgatc actttctcag gccaggtggt 2518501 attgcggccg cccttcagcg aaaatccaat catagccacc aatatgataa tacacagaag 2518561 taatagcatt aaccgcttat tcggcatcgt gttacacctc ttctattgaa ctcccgatta 2518621 tctagttttc cctttgaaaa gatggatgtg ctccagtgct ttccctgttc cgatcgctac 2518681 acaatcaagc ggatcttcgg cgataaggac cggcattttt gtttcttcgc tgatgacttt 2518741 gtccaaattg cgcaaaagcg ctccgccgcc ggttaacact atacctctgt ccatgatatc 2518801 tgctgcaagc tcaggcggtg ttttttcgag tgtgctcttc actgcttcga caattgtaga 2518861 tacagtgtcg cgtagagcgt tagaaatctc ttttcctgta atttcaattg ttttcggcaa 2518921 acctgtgagc aaatcgcggc cgcggatttc catgttgtcg gattcttcag gagcttctgc 2518981 agatccgatt tccattttaa tcgcttcagc cgtacggtca ccgatcatca gattgtacgt 2519041 ttttctgatg tagttgataa tcgcgtcatc catctcatca ccggctacac ggattgactg 2519101 agacgttacg atgcctccga gggaaataat cgcaacttct gtcgtaccgc ccccgatatc 2519161 aacaaccatg cttccagtcg gttcccaaac tggcagattg gctccgattg ctgcggcaaa 2519221 aggctcttca atcggatacg cgtcacgcgc tcccgcctgt cttgtcgcat cgataacagc 2519281 gcgttcttca acagctgtaa tgcctgatgg gacacatacc attacatatg gttttctggc 2519341 aaacatgcct ttatttttta tggcctgatt gatgtaatat ttcatcatcg tcgccgttgt 2519401 ttcataatca gcgataacgc cgtctttcat cgggcgaaga gccaccacgt tgcccggtgt 2519461 ccgtccaatc atatttttcg catcatttcc gacagcgaca atcgatttcg tatccgtctg 2519521 caaagcgaca actgacggct ctctcacaac aattcctttt ccttttacaa aaacaagcgt 2519581 attcgcagtt ccaagatcta taccaaggtc tctagcacca attccaaaca tatgtatgta 2519641 tcttcctttc ttaaagcaaa aataccctaa agggaaaaac tcataaactc tattatagct 2519701 taattcgacg aaaaaaaaag tgttacaaat atcctttttc ctttaaactc acaaattttt 2519761 tatccccgat caccaaatgg tcaagcagct cgatgccaat caggtttccg cattcaaaca 2519821 gccgtcttgt cacttcaata tcttccctgc tcggcgtcgg atctccagaa ggatgattat 2519881 gaacacagat aaaggaagcg gcagatcgtt taaacgcttc tttaaacacc tctcgcgggt 2519941 ggacaataga tgaattcagg cttccgataa atacggtgcg tttatggatg acttgatttt 2520001 ttgtatttaa gtataaacag acaaaatgct cctgggttaa aaagcgcata tcctccatga 2520061 caagattagc gccgtcttcc ggggagcgaa taacgaaatg ttcttcgttg gctaatttat 2520121 gaatccggct tccaagctca actgctgcca gtatttgaat cgcttttacc ataccgattc 2520181 ccgggatgct tgacagctct tcaaccgatg cttccttgag caggcgcagc ccgtcaaatg 2520241 agcgcagcag ccggtttgac aggtccaaaa cagattcgtg tttagtccct gtccgcaata 2520301 atatagccaa aagttcatga ttcgctaagt tctcggctcc gactttcagg agccgttccc 2520361 ttggcttttc tttcattggg aaatctttga gttttaatgg cagatcgtgt atgaccaagc 2520421 actccttttc tttcccttcc cgtttataga accgtcatgc ccttatatca aaatggcgaa 2520481 gagctctcat tgtttttgat ataggaaggc ccatgactga ataataatct ccgtctattt 2520541 tctttacaaa aagcgcgcct cttccttgga tgccgtatgc acctgcttta tccatcggct 2520601 cttttgtttc aatatatgtc caaatctctt cttcactgag ggaccaaaac gcaacttctg 2520661 tcttatcata aaaagtctcg ctgtgatttt cagcttgaat gctgaccgcg gttattactg 2520721 agtgacttcg gcctgaaagc ctccgcagca tagaagcagc ttcttcttga tcctgcggtt 2520781 tgccaagaca ttcgccgtca aggcatacca ttgtatcagc accgataacg attgcatgcg 2520841 ggtggagatc agctacagcc ttagcttttt gttttgccaa ccattggacg ttttcttctg 2520901 gtgaaaagtt tcgatttaat ttttcttcta cttcactgac aataatggag tagggcagct 2520961 ggagaagatc gaggagttct ttcctgcgcg gagattgtga tgcaagtatt agcggttttg 2521021 tcatgttcgt catcctttca gggtttgctt aagaaaaaaa gatactcgtt tatcctacca 2521081 aatcacgagg cttgtcacaa tttcagaaaa ataacttttt catgacaaaa taaaaaaagc 2521141 ctgtcactaa aggacgaagg ctcagggcac tatctcttat tttacgacgg ctaacagctc 2521201 ctgctgagcc ttccacccgg cttcagcact tggatcctct aattccttta aagcctgcaa 2521261 aatcgctttt ttctctcctg tttctgacgc ttttgtttca ccaagcgact tttctatttt 2521321 ctctacactc gcttttgtaa tgtcttcgtc gagaatcgcc tttgctgcaa gctccgctgt 2521381 ttccttaaaa gaatctgtca tatctgactc tattgataag gaaagctcct tgcctcccca 2521441 ggcttcaaaa tcactgtcga ttaaaacctg tcctaactgc tgtgagacct ccttttcact 2521501 tgctaagcct gcaataacat acgtataccc gtcatccttt gacagtgaca cggcggaata 2521561 tcctttttcg gtcaattgtt ctgttaacgt ttcggcgccc ttttcatttg aaaattttcc 2521621 ggcttgcaca gcgtatgttt tgtatgtacc ttcagtttgt gccgcttgtt tttctgcgcc 2521681 tgaggtttgt ttatcagcag aagtatcccc tgcttttgcc gtttggctgc ctaaagaatc 2521741 ctctaaagag gccggtgctg acgcttcttt attccccgat atgtttaacg cgaataaccc 2521801 taatccagtg ccaatgacag ccgcgaaggc aatcgtcgcg gccactcttt ttaccggttt 2521861 ggcagccccg gtctttcctt ttgcgtaaag ctttgttttt ttcttttgaa aaggaggaac 2521921 aactttaggg tcctctttaa acaccttgtc ctcctcggaa tcccaattga attcatcttc 2521981 atcagggtgt tcctgggatg ccgcaacctc ttgttctgcc tgtctttttt cctcccaatt 2522041 tgaaaatgtc atgcttttat tcgcctctgt ctcaggcgtc tcttgttcgt aaaccgtctc 2522101 ttcttttcca ttaatcgtca ccttgagggc tttttctgcg gctttactgt tttttttatt 2522161 ctttcttttt ttcaattccg cttcctccct tcatttgctt gaccgttctt gtcggctttt 2522221 catgctacac actttagcac aggcaaagaa aaaaagaaca agacttttgt cgccttgtcc 2522281 aaaaaacgtt cgtcaaattt ttcagcagtc agcccaatgc cattttgata taaaaagaaa 2522341 tgatagagtc accgtataaa taggctaaaa tgctccctgc ggctatagcg ggggcgaagg 2522401 gaagcggctg ccttttagcg agtctaccag tcagaacagc tgccgctcca tataatgcac 2522461 ctatcaaaac tgaaaagaaa aaggcagctg ccagcatttt cacaccaagc acaaagccaa 2522521 tcaccgcaaa taatttaata tctcctcccc ctactccccc atgggtgatt gcggcaatta 2522581 cagccagaaa caaaaatccg gctgccgcac ctaacaggcc tgcataccag gaatcaagcg 2522641 gagaaatcaa tctcgcggcc gccaaaaagg gaagaaagaa aatcaatatt cgatttggaa 2522701 tcagcataaa atgaatatct gtcactgcaa caataatgag aagagagata aacaccacag 2522761 cgggaaacag ttccagcgat atgccaaagc gtattcctgc ggcggcaaat aaacacgctg 2522821 tcacaagctc tgctgcggga tacataaaag aaatcctatg cccgcagctt ttacatttac 2522881 ctttttgaaa taggaatgac aggatgggaa ttaattctgc aggagttaat gttcgccggc 2522941 aaaacgggca tgatgaacgg ggcgcaataa tagatagatg taaggggata cggcacccgg 2523001 ccgtatagta aaaagaacca aggataagcc cgaagataaa aagaatggat agcatagaca 2523061 acacaccttt actcattgag ttctggtatg gattgtagca aaatggacat cctgagctcc 2523121 aattgggaat attcaatttt acacatgaaa aaaacggcag aatctttttt tgattctgcc 2523181 ggagccggat gcttttattt caaccttttt cgaatgtcag aaataaagta aagagatccg 2523241 gtaatcagca caatttcatt tgagcccttt ttactttcta tgaatttgat tacatcgtct 2523301 ggatcttcac tccagctttt attgctgatt tcacttgcat catagagatc ttttgcaagg 2523361 gaagcacgcg ggaaatcaaa agaagcaaaa tgaatcgcat gagcaatggt ttccagtctt 2523421 ttaatcatgt tctgatacgg tttgtccttt aacgcgctaa acaccacaga aatgcgtgaa 2523481 ttggcgaaac gctgcttcat cgtttccgcc agcttttcaa caccttcttc gttatgcgca 2523541 ccgtctaaat ataccggagg atgttcctga acaagctcta accgtcccgg ccaagcagcc 2523601 ttcacaagcc cgctccttaa cgcttcgtca ctgatatggg cgatattctc cttattgagc 2523661 cactccgcag ccaaaatgga caaagcagca ttttgtcttt gatgggtgcc aatcagagat 2523721 gtccgaatat cttcatagca tttctcttcc gttttgaatg aaaactgttc tcctgcaggc 2523781 agagcctctt cattgaaaat aacacatgca tcatgcaatg actggaacgg cgcagcatgc 2523841 cgttcggctt catggcggat gacctgtaaa gcttccggct gggtaactgc tgtaacgatt 2523901 ggaatacctt ctttaataat gccggccttt tctcctgcaa tttcttcaat ggtgtttccc 2523961 aaaatgttca tatgatcgtg tccgatgctt gtaatcacag ttaagagcgg ttcaaccaca 2524021 ttagtagaat cgaatctacc gcccagacct gtttcaaaaa taacaaaatc gaccttatga 2524081 aactctgcaa aatataaaaa tgcacaagct gtcataattt caaattctgt cggctgtccg 2524141 tattccgttt gatcaagggc ttcaacgtgc ggtttcattt gattgacgag tgctgtccat 2524201 tcctcatctg aaatcggtat cccgtttacg ctgatccgtt cattaaacgt aataatataa 2524261 ggcgatgtaa atgttccaac cgtatatccg gcttcctgca gcatagaacg gataaaagcg 2524321 acagttgatc ctttaccgtt tgttcctgcg acgtggaacg ctcggatttt tttttcagga 2524381 tgtcctaacc gcgccatcag ctgtttcatt cgaccaagtc cgggcttcac cccgaatttc 2524441 agcctcccgt gaatccagct gcgcgcatct tgatatgcag taaacaatga taatcccctc 2524501 ttttataaga caaggcggtt tctctagaaa ccgccccggc ttttcattaa cccttcagct 2524561 cagccattcg tttttgaaca gcgtcacgct tcgccacata atctttttct ttttcacgtt 2524621 cttcatcaat tacgtgtgca ggcgcttttt tcataaatcc ttcatttcca agtttctttt 2524681 ggacacgctc aacttctttt gtcagtttat caaattcttt ttgcagacgg gcaatttctt 2524741 catcaatatt gattaagcct tcaagcggaa gaataacctc tgctcctgag acaacggccg 2524801 tcatcgcctt atcaacagcc tcaatatcgg tgccgatttt aagcacgctc ggattcgtaa 2524861 agcgttcaac atatgaacgg ttcgcttcga ggcgggacgc tatttcgtct gtgcttgttt 2524921 taatgtacag ttcaacctgc ttgctcattg gcgtattgac ttcactgcgg atattgcgca 2524981 cagaacggat cagctcaaca agaagcttca tgtcagctgc cgcttcagta tcggtatgct 2525041 ccggcactac tgcaggccat tgacttactg taatcgattc cccttggtga ggaaggtgct 2525101 gccaaatttc ctccgttaag aatggcataa acggatggag cagacgcatc gtttgatcaa 2525161 gtacgtaagc aaggatggaa cgggtagttt tcttagccgc ttcgtcttct ccataaagcg 2525221 gaagcttcgc catttcaata taccaatcac agaaatcatc ccaaataaag ttatataaat 2525281 ggcgtcctac ttcaccaaat tcatatcggt cagcaagctg ggtcacgtgc tcgatcgttt 2525341 catttaatcg cgttaaaatc cacttgtcag cgactgactt ttcacctgac agatcaagct 2525401 catcgtacgt catgccatcc atattcatta atgcaaaacg ggaggcgttc caaattttat 2525461 tggcaaaatt ccaggtcgat tccacttttt catagctgaa gcgcagatcc tggccaggag 2525521 agcttccagt cgcaaggaaa taacgcagag aatcggctcc gtacttgtca atcacatcca 2525581 tcgggtcgac accgttgcca agagatttac tcattttccg gccttgctcg tcacggatta 2525641 agccgtggat taaaacatct ttgaacgggc gctcgcctgt aaattcaatg ccttggaaaa 2525701 tcatgcgtga tacccagaag aaaatgatat cgtaccctgt cacgagaaca tctgtcggat 2525761 agtagcgttt aaagtcttca gccgttacat caggccagcc cattgtggag aaaggccata 2525821 gcgcagaact gaaccatgta tccagtacgt ctgtatcctg ttcccaattt tcgctgtctt 2525881 ccggcgcttc aagtccgaca tatagctcgc ctgtttcttt atgataccag gcaggaatac 2525941 gatggcccca ccacaattga cgggagatac accagtcgcg gatattttcc atccagtgta 2526001 aatacgtttt ttcgaaacgg tcaggcacaa agttgacctt ttcttctttt ttttgcagct 2526061 caatcgctgc atcagcaagc ggctgcatgc gcacaaacca ttgtgtagaa agataaggct 2526121 ccacaacagc cccgcttcgt tcactatggc cgacagagtg catatgatcc tcgatcttga 2526181 agagaactcc cgcctcctgt aaatctttca cgagcttttt gcggcattca aaacgatcca 2526241 taccttgata ttggagcgca ttttcattca tcgtgccatc ttcattcatg acaaggatgc 2526301 gttctaaatt gtggcggttg ccaagctcga agtcgttcgg atcatgagca ggcgtaattt 2526361 tcacggcacc tgaaccaaat tccatatcaa catagtcatc accgacaatc ggaatttcac 2526421 gatttacaat cggcaggatc accgtttttc cgataaggtg tttatagcgc tcgtcttcag 2526481 ggtgaacggc aacagctgta tcaccgagca ttgtttcagg acgtgtcgtc gcaatttcaa 2526541 ttgagcctga accgtcagca agcggatagc tcatatgata gaatgcgcct tgaacatcct 2526601 tgtaaatcac ctcaatgtcg gatagggctg tttttgtcgc tgggtcccag ttaataatat 2526661 attcgcctct gtagatcagg cctttttcat aaagcttaac gaatacttcc cttaccgctt 2526721 tgctcaagcc ttcatccagc gtaaaacgtt cacgggaata atctaggcca agacctaatt 2526781 tcgcccactg gctgcgaata aagtcagcat attcttcctt ccacttccac gtttcttcga 2526841 ggaatttttc acggcctaaa tcgtagcggg atttgccttc ttcacgaagt ttcgcctcca 2526901 ctttagcctg tgtcgcgatg ccggcgtggt ccatgccagg aagccacagc acatcatagc 2526961 cctgcatgcg tttcattctt gttacaatgt cttgcagcgt tgtgtcccat gcgtggccaa 2527021 ggtgaagtct ccctgttacg tttggcggcg ggatgacaac agagtatggc tcttttgtct 2527081 ggtcactgcc cgcttcaaaa aatttgcctt ttagccaaaa atcatatcgg tctttttcaa 2527141 ccgctgccgg atcatatttc gtcggcattg tttgttcatt cgtttccatc ataaccctcc 2527201 agcatgttta aaaatggctg agaacgaaaa aagagctctt catccctgta aaaggacgaa 2527261 aagctctttc gcggtaccac cttttttcat gaactcaatc agttcatgca cttataacgg 2527321 ataacgggtg tttcccgaat ttctctactc ttctttcaag aaattatgct cccgggcgac 2527381 cttccaatca gacaacataa gaagcctttc agcaaacggc ttctctctct gcatgcgcct 2527441 tttttgtact cttcccgttc taagcaggtg tatttatcag ctcattgtat acattattta 2527501 tgttctttat tatagtaaaa gtgtttttga ttcgtcaatc atcttttcca aaaacaccgc 2527561 tttctataca gatgggcagg cacctattgc ccaagtttac atatgatgct tgtaaatgcg 2527621 tagaggagga tgcaccgtga agaaacgttt cagctcttat tcgctgccgc catgggtaag 2527681 gcaaattcgg cttgtatccg cacaagtgat tattcccatt acgatttttc aaggaatcag 2527741 aaccattttc tttccgacaa cctttgatgt tttgctgctc gcaatcctaa tctttttagc 2527801 ttgcgccctt catttagaat ggatataaac aaacaagtcc gcgccattaa gacgtggact 2527861 cgttttcagc ctgaaatttt ttctcttgtt caatctgatg aattttcatc acaaacggct 2527921 ctatgttttt catttgccaa taagccttta ataattgtgt acattcctct ttttcatgct 2527981 gtcttttccc agtttgataa ccgttcagca ccttgtacat ggctgccgga tatgccatat 2528041 agctgagaaa aaggctgact tccgcttcac gcaaagggaa tgatttcgta tatccataaa 2528101 accattcgac gcattccgga caagctttcg gaaagcctct gaacattttt gtataaaagc 2528161 cgagcaggtc gttttgcggc ggaccgacag atgctctttc gaagtttgta aaatatccgg 2528221 tcccggcatc attatacaga aaatggtgta tagacaggct gccgtggttc attacaaccc 2528281 ttgaaacgtc cttttccttt gcggactcat accagtcctc cagccgttcc agcgcaaagt 2528341 tcaccgcgga aatggtttca gaaaaatagg ttatggcctg gagttcaaag ggagaaaggt 2528401 accattcctt ctccgctcta tccacaaact gctcatagaa aattttatct tgttcccact 2528461 tttttttcgt ttgcccgtaa taacgttcaa tctcatcacg tctaaccttt agttcctgcg 2528521 cggttctctc gtgaagacgg gctgtttctc taaataaata agcatgtttt tgatcccgtt 2528581 cttcctcttg gtcaaattgg agccaaggca ttaaatagta gatatctccg tattgtatgc 2528641 ctgctgagaa aaactcaccg ctatttgttc tgtaaacggg aacgaatgaa cgaaagcctt 2528701 tttcctcaat cgccaccata tgatctgtaa aatgcttgcc gcgaccttct ttcaattttt 2528761 tcagggcaaa tatgccgtag tctgtataca ctttccaaac aagaggactg acaggctcaa 2528821 taaattgagc agtcagtccg tattcctgaa gaaccgattg ggtatcttcc atttcattca 2528881 ccacattttc cgatcactta cggtttacgc atggctattt ttatattgag gaatatagag 2528941 aatctgtcct gcttttaatt catcatccaa ggctaaagaa ttcatcctga tcagctgctg 2529001 ggatgtaatt tcataccgtt cgcataaacg ctcgatcgta tcttcctgct gcacaataca 2529061 aattttcatt ctcgaaaact catccgcttc ttttgtaaag agttttgtta aataaagaga 2529121 attatcactt tcctttgttt gaggttcctt cgtttcagca gcaggagcaa ccctaggaac 2529181 agcatccgtt tccttccttt cagtctcaga agattcaggc agctggaagg attgaaaagg 2529241 tgtttcttcc ttaggctctt cagctgatgg tgtttttctc acttcaattt cgaagctctc 2529301 ttcctcttgt tcttcctcct ccagcagctt aggcgctgaa taaaaagaat cctcctcttc 2529361 ttgttcaggc aggaaggtac ggtatgccgg ttcaggcaat tcttcttgag atgcctcctc 2529421 cgagcttgtt ttttgattga aatggaaatg taaatcggca ttgtcattct ccatatatac 2529481 agctgaagct gtttctctgc tatcttctat ggagagagcg gcctctgata cactctccaa 2529541 agcttcatcc ggttccgcct cttcttggca aagcgcagga tcagcctgat ccgattgagc 2529601 tgcttcttca ttttgagcct cttggcgcag cgcatattca tgattaggag acactgttgt 2529661 ttcctctttt tcctttgcaa tcacagtctc tgaatgaagc tcagcttcca aagcaggcga 2529721 ttcttctgct ccaacgtgtt cacgaagctc agtctccgct ggagagtctg cttcttcacg 2529781 aacatccgct attgcagctg ccggctctgc cgtttctttt tttgctttaa cgatctcttg 2529841 aatctctatt tctgaaggat caggttctgg ctcagattct tctgtttccg attcagcacg 2529901 aacctccgtt tccggcacag caagctcttc tgactcttct tcctctttca catcttctct 2529961 ggcctctggt tctgaagcaa ccgattcagg cggctcagat tctgcttttt ctgtctccag 2530021 ttcttcacgg agccccgctt tcgagataaa aagttctggc ggttcggctg gcggttcatg 2530081 ctgaagaact gcttcctctg ccgatgatgc acccggttct tctactacac tatgtgccgg 2530141 cggctctgaa agctcttcct ccctgaatgc cgcaggagct tcatataaag gtatctccgg 2530201 ctctttgtct tgcgtatcgt ccaaaagccc ttcgatcgct aaatcagctt gaattgttaa 2530261 aatgcgcgaa tccgtcaatt gatagtcaaa tgcgtcaata aagacgaaga catcctgtaa 2530321 atggctcact ttatttttcg gaatggtaat atccacagga aaacagtgag tcagttccgc 2530381 acttccatcc tctctctttc tgacttgttc aacaaaccgc ttatctgtat aaatctcttc 2530441 ggtatgtttg ttttgatcta tgttgtactc acctgtaagt tcaagcgatc ctatgattga 2530501 tacataatca tttacttcct gaaccctaat atcaggatct aatgaaatag aaagcagttc 2530561 agaaacttcc tgtccttttt ggaaacagat cgattcttct acagaaaatt gcaatcgatg 2530621 attttgcggc aagttcatat cctcctttca tctaatcctt aaaattagat gtcactaaag 2530681 gtgtatgtat gaactggaga aaatatgagt gggagagcac gaaaaaaccg gcacaaggag 2530741 tccttgatac cggttttcac tcttatctgc ggctgatctc agcaaatact ttctcagctg 2530801 cctggattgt gttttcaata tcttcatcag tatgggccgt tgagaggaaa agaccttcga 2530861 attgtgatgg cggaaggaat accccttcat ttgccatccc tttataatag cttgcgaaca 2530921 gcttcaaatc agatgatttc gctgtttcat aattgatgac tggttcgttt gtaaagaaga 2530981 aaccgatcat cgaacctgca cggttaaagg tatgcggaat gccatgagcc ccggcggttt 2531041 ttgaaattcc ttcttccagt ctgtcgcctt ttttgatgaa attcttgtag gattcaggtg 2531101 tcagctgttt caatgtctct aagccagccg tcatcgcaag cgggttgcct gacaatgtac 2531161 cagcttgata gatcggaccg cttggagcga tctgctccat gatttctgcc tttccgccat 2531221 aagcgccgac aggaagtccg cccccgatta cttttcctaa acaagtcaga tcaggcgtta 2531281 cgccgaagta gccttgagcg cagttataat cgacccggaa gccagtcatc acttcatcaa 2531341 aaatcagcag ggagccgtac tgctcagtga tatcacgcag accctgaagg aaaccttctt 2531401 gcggcggaac aacacccata tttccggcaa ctggctctac aatgactccc gcaatgtctt 2531461 caccgaattg ctggaaagca agctttacac tttctaaatc attgtacgga acggtgatgg 2531521 tgtttttcgc aatgccttca ggcacccccg ggctgtcagg cagaccgaga gtggcaacac 2531581 ctgaaccagc tttaatcaag agagaatcgc cgtgtccgtg gtagcagccc tcaaatttta 2531641 aaatcttgtt gcggcccgta tagccccttg ccaaacggag ggcactcatt gtagcctctg 2531701 ttccggagct taccattcgt acaatttcta cagatggcac acgatcaatg acgagcttag 2531761 ccagttcatt ttctacttca gtcggagcac caaagcttgt cccgtattca gccacttttt 2531821 tgaggctttc tacgacgcgg tcatttgtat gccctaaaat taaaggcccc catgacaaga 2531881 cgtagtcaat atattcattc ccgtcaatat caaagatttt cgagcctttt ccgcgctcca 2531941 taaaaatcgg gtccatgtct accgatttaa atgcgcgaac gggactgttc acaccgcccg 2532001 gcatgagttt ttgcgcttct ttaaaagccg tttttgattt ttcatagctt ctcatctgcc 2532061 tcaactcctg tcaactgaat aaaattactc cgcaagccat ttcgctgcgt ctttcgcatg 2532121 atacgtaata atcaggtcgg cacccgcgcg cttcatgctt gtcaaaattt ccaacacaat 2532181 ttctttttct ttgatccagc cgttctgcgc tgcagccttc accattgaat actctccgct 2532241 tacattataa gcgacgagcg gcaaagtaaa ctcatttttt acgtcacgca tgatatccat 2532301 ataagaaagc gaaggtttga caatcaaaaa gtccgcgcct tcctcaacat ctgattgtgc 2532361 ttcgcggagt gcctccatac ggttggcagg gtccatctga tatgttttgc ggtctccgaa 2532421 ttgcggtgtg ctgtttgctg catcacggaa cggaccgtaa aactcacttg aatatttaac 2532481 agcgtaagac atgatgggaa tattgacgaa tccttcttta tcaagtgctt ctctgatcac 2532541 tgtaacaaat ccgtccatca tgtttgatgg cgcaatgata tccgcacctg ctttcgcttg 2532601 gctgacagct gtctgcgcca aaagctccag cgattcatca ttgagaatga ctccgtcttt 2532661 gacaagtccg caatggccgt ggtctgtata ttcgcacagg cacgtgtcag cgacaacaac 2532721 catttcaggg aagtgttctt taatttctgt gatggctttt tggacaattc cgtgatcatg 2532781 gtacgcttgt gttccgcaat catctttttc ttccgggatg ccgaacacga taacagattg 2532841 aatgcccagt ttgaccagct ccgctacttc atccttcaat aaatctaatg atacatggtg 2532901 aacatcaggc attgacggaa cagctttttt gccttccagc ccttcaacga caaaaatcgg 2532961 atatataaaa tctgatggat gcaaacgtgt ttcctttacc atttctctca ttgcttttga 2533021 tgtccgcagg cggcggtgtc tattaaatga ttgactcata ttctctcttc ctctcttgac 2533081 atgctgcaca ttaactcaag catgccatct attgtaaatg tatcaggcgt atgcgatgtg 2533141 atgccgtacg tcagaagggc atcatttgtt aaaggcccaa tgctgataca ggccgtccca 2533201 ttcgccttcc acttttttaa ttcttctccc aagacatgca taaacgtatg tacggttgat 2533261 gaactcgtaa atgttacata gtcaaaggaa tattgacccg cagcgtcttt caatgcctca 2533321 atgccttctt catccggaat cgtttcgtag agaacccatt cctttacttc aaaaccgagc 2533381 gggacaagct cttgttttat cacatcacgt gacaaattcc ctttcatcac ggtaatggtc 2533441 tcccccggtt cagcatgctg cttaagagcg tcagccaatt gttcagcaat atactcctgt 2533501 ggcatcacat caaccgatac gttatgcatt tttaaacggc gcgcggtttt ttcaccgacg 2533561 gctgcaattt ttttatgcgc agggagaata agctgatttt ccttcagata agaaaaaaag 2533621 aagtctgccc cgttcacact tgtaaaaaca agccagcctg gcgcggcaag atcctctctt 2533681 acctgttccg caacatcatt cggcaaagcg cggcgaaacg taatcaaaga ggttaaaacc 2533741 gctttaccgc caagcgcctc cactttttgc tgaaatgatg ctgcctgtgc cttattccgg 2533801 gtgacaagca ctgtttttcc tttcaacgga aaatcatttt ccatcctcgt caagctcccg 2533861 ttttacacga tcaattaaat cttttgctcc tttgtcagcc ataagagcgg cacagcgctt 2533921 tcctacttcc tccggatcgt ttccggtgac ggtttcttta aaaatgattt tgccgtcagg 2533981 tgaagcgaca agacctgtca tttcaatttc atcctgtcca tttaacacgg agtagcccgc 2534041 gatcggaacc tggcagccgc cctccatcgc gtttaaaaaa gcacgttccg ctaagacagt 2534101 ccgttttgta tattcatctg taaactgaga aaacaacgcc aacagctctt catccgattc 2534161 tcggcactca atcgccaggg ctccctgccc cacagcaggc aaacagcgct caggctcaag 2534221 gaattcggtt acgacatctt gcttccaacc cattctggaa aggccggcag ccgctaaaat 2534281 aattgcgtca taatcctctg tttccagctt ttgaagtctt gtatctatat tacctctaat 2534341 ccatttaatt gtaaggtcag ggcgctcaat caaaagctgc gcgcttcttc ttaaactgct 2534401 tgtgccaatg acagcacctt tcttcatttc tgaaagcttt acgcgattct ttgaaataag 2534461 ggcatcacgc gggtcctccc gttcaggaat acagccgatc acaaggcctt caggcaaaac 2534521 agcaggcatg tccttcatgc tgtgcactgc catatcaatc tcttcgttta aaagcgcctg 2534581 ttcaatttct ttgacaaaaa gcccttttcc acccactttt gagagtgtaa catcgacaat 2534641 ccggtcgccc tttgtcacga tctctttaat ttcaaaagca aacgaaggat tgatttcctt 2534701 cagtttttga ataacccatt ttgtttgagt catagcgagt ttgctccgtc tggaacctac 2534761 tttaatcgtt ctcatcattt ctttcctccc gaatctgctt gggacatcgt ttaactgaac 2534821 caatggaatt gcgacaggct tccaagcagg aaataattga tcatcagcac cagaaaacaa 2534881 gccgtattcc acagtgcagc gacctttcct tgcagctcct taatcagcct gatataaaga 2534941 taatagctgt acagcagcag gacgacaaac gaaccaagca ctttggcgtc aaaccaatac 2535001 agcgtttcta gtgagacata cgcccaaatg acgccgagaa tcaaactcag cagcagcatc 2535061 ggaaccccaa tgacatttaa aacatacgcc atataatcaa gcttagataa atcttctatt 2535121 ctcaacagcc attttcccca ctttttcttt ttcagcagat gatattgaaa catatatagc 2535181 acagaaaaaa cgaaagaaag ggaaaaagcg ccgtatgaaa gaatcgccat tgtaatatga 2535241 atcaccaaaa gctcggatac aagctgcccg gaaaaagcag ctgactgctg ctctgtcggt 2535301 gaaaatgtgt gaatggcgat catagaaaat cctataacat ttgtaaaaaa cacgataaag 2535361 tcaacacgta aaagctttgt cagtacaagt gacagcgtga caagcaccca ggcataaaaa 2535421 taaagtgcct ctgtcacatt taataccgga aaccgccccg tcacccacat aaaataggcc 2535481 aaatacacgg tttgcagagt ccagacaata gaaagcaacc agaaggccat ttttccagcc 2535541 ttccggttgt gttgaagaaa atctataaaa taaaagagta cacttaacgc gtaaatgacg 2535601 attgtcccct cattaagtct tgccattgca gtatcaatca ttcagctttc actcacttac 2535661 aagtgggcta aagcccgctt ttgattcagc cttcttaaaa gagtggacct tctggctgct 2535721 ttcaacggtt ttcatcattt gacggcccgc agcttcttca atatcaaaaa tctgcataaa 2535781 caacgcgagc ttttcttcag aatcagcatc tgccgcaagc tctttcacct ttaaaatcgg 2535841 atcacgaagc atttggttaa taatactttt ggtgtgtttg ttcaacagtt ttttctctct 2535901 tgtgcttaag tgaggcagct tacgctcaat gctgtccatc gtttctgact ggatggcaag 2535961 cgccttttcg cgcaatgcag aaataacagg cacaacacca agtgtattca tccattgttt 2536021 aaattccaca atggtttctt caattaacag ttcaactttt tcagctgttt ctctccgctc 2536081 tttcatgttc gcttctacaa tgccttccag atcgtcgata tcataaagaa aaacaccttc 2536141 aagatcattc agcgccggat caagatctct aggcacggca atgtcgacca taaacagcgg 2536201 acgtcccttg cgaagcttat tcgcgttttc catcatctct ttggacacga caaattcact 2536261 tgcaccggtt gaactgatta aaatatcagc ctccgcaagc gcgctttcaa gctgattcaa 2536321 gcttctcgct tcacctgaaa aacggtctgc aagctccttc gctttcaagt atgttcggtt 2536381 aatgacagtg accttgccga ttccctgtcc gtgcaggttt tccgcagcaa gctcgcccat 2536441 ttttcccgca ccgagaatca atatgtgctt gcttgaaaga tttccgaaga tttttttggc 2536501 aagttcaact gcagcatagc ttactgacac cgcatttgag ccaatgtctg tttcggcgtg 2536561 agtccgtttg cccactgtaa ctgcctgctt aaacagctca ttaaaaatag tcccgatcgt 2536621 tttttcttgc tgagctgttt taaagctgtc gcgtacctgt ccgagaatct gcgtttcgcc 2536681 aatcaccata gaatcaagtc cgcaggctac acggaataaa tgctcaacag cggcatcgct 2536741 ctcataaaac gttaagaacg gtgacagctc ttctttgctt aattgaaacc aatcagctaa 2536801 aaactttttt atataataac ggccggtatg aagctggtcg actaccgcat aaatttcagt 2536861 gcggttgcag gttgagacaa tgatgttttc aagaatgctt ttctcttctt tcagctgcac 2536921 cattgcttct gccagctcat tcggctgaaa acttactttt tcacgtatct caataggggc 2536981 ggatttataa tctactccca caacaagtat atgcatcgct ctaattacac ccccaacacc 2537041 caatcttaat ttataatcat tctaacatag aactcattat ttataataat tataacatag 2537101 tttctttcac aaaatgtgaa cagattttaa aattcttatg ctatattaga aaaagcttca 2537161 gggaaaagaa gcattcctat tgacaatacc aaaaacagca gaaatttact acacatcagc 2537221 tctaaaaaac aagaaggtga tatgcatgaa acaaaaatca attttattcc cttgtctgct 2537281 gcttgccgct tctgtatatg catggctaga aagcggccaa gccgaactgt tttcagggca 2537341 ggatcaatgg cctgttctcc tcatgctgtt aggcgcagcc tttgtatatc aaggaaaaaa 2537401 agaagccgtc acaccccatt tttttatcgg tttgcttctc ttcgggatcg gtttacactt 2537461 ttttgccaag ccgaaatggg tatggtggcc ggatgatttt gaaatgctcc tctttatgat 2537521 cggcttctca cttctcgttt caaccgttca aaaaaaagaa tatgtatatg aagctgtgtc 2537581 gatgatttgt ttttccctgt ttttgtactt tttcaaacaa attatggcat ggcttgagtc 2537641 tgcgcatatt ccaacagcgc ttctgaagga gtattggccg tttgtcttta ttggaatcag 2537701 tttattgtta ttattgataa aacgaaaaaa atctatacga taaataaaac cggtagagga 2537761 tcctctaccg gtttatcatt tttttgatcg ctccccaagc ttcgtctttt ccctttttcg 2537821 tttctgaaga aaagaggatc agctcgtctt ccggatcaat atttaatgtt tgtcggacaa 2537881 ccttcgcgtg tttgtcccat ttacctttcg ggatcttatc cgcctttgta gcgataacaa 2537941 taacaggaat gccgtaatac tttaaaaatt catacatctg tacatcatca ttagatggcg 2538001 catgccgcaa atcaacgatc tgcaccacag cttttaattc ctcgcgtgtc gtgatatagg 2538061 tttcaatcat tctgccccat gcttcacgct cagactttga cactttggca aaaccgtagc 2538121 ccggcacatc cacaaaatgc agctcatcat tgataatgta gaaattaagc gtttgtgttt 2538181 ttcccggctt tgatgacgtt ctcgcaagat ttttgcgatt gattaatgaa ttgataaaag 2538241 acgattttcc tacgttcgat cttccggcca atgcgatttc cggaagcccc ccttcagggt 2538301 actgttccgg ttttactgca ctgatcacga tttctgactt tgtgactttc atttcttctc 2538361 tcctactaag gcatgttcca aaacctcgtc taagtgggac gccaatataa atgtcagccc 2538421 ctccctgacg ctttccggaa tatcctctat atctttttca ttatctttag gcgcaataat 2538481 ggtcgttaat cccgctctat gtgcgccaag cgctttttcc tttaagccgc cgatcggcag 2538541 cacgcgcccg cgaagcgtga tttccccagt catgccgact tcacgcgaaa ccgcccgtcc 2538601 cgttaaagca gaaacaagcg ctgttgccat cgtaataccg gctgacggac catcttttgg 2538661 caccgcaccc tctggtacat gtatatgaat atcatacttc tcatgaaagt caggttcaat 2538721 gccaagttct tctgttttgg atcgcacata gctgaatgca gcctgagcag actctctcat 2538781 aacatctccg agctttcctg tcaggattaa tttccctttt cccggtgaaa gcgatacttc 2538841 aatcgaaagc gtatctccgc caacggttgt atacgcaagc cctgtcacta caccaacttg 2538901 atcctctgtt tcagcttgtc catatctgaa aatgcgtttt ccgataaaat cttgaaggtt 2538961 cttctcagta accgtaattc gttttcgctc ttcagcaaca atggcttttg cagctttacg 2539021 gcaaattgcg gcaagctggc gttcaaggct tcttacaccc gcttctctcg tatagtaacg 2539081 aataatatca agaatcgcct gatcacgcag ctgaagattg cttttcttca gcccgtgttc 2539141 tttgatttgc tttggaagca agtgatcctt tacaatttca agtttttcta tttctgtgta 2539201 gcctgcgata ttaataattt ccattctgtc tctgagcggg cccgggattg tggccaaatt 2539261 gttcgccgtt gcgataaaca gcactttgga taaatcaaag gtttcttcaa tatagtgatc 2539321 actgaagctg ctgttttgct ctggatcaag cacttcaagc atagcggatg atgggtctcc 2539381 tctaaaatca gatgacattt tgtcaatttc gtctaataag aagaccggat tcagcttgcc 2539441 cgcttttttc atcccttgaa taatacgtcc aggcattgct ccgacatagg tccgtctgtg 2539501 tccgcgtatc tctgattcat cccgaactcc tccgagtgag attctgacga atttgcgtcc 2539561 caagcttttt gcaattgatt tggctaaaga cgtttttccg acacctggag gtcctgccaa 2539621 acagagaatc gggcctttca gggattttgt cagcttctgg acagccaaat attctaaaat 2539681 acgttctttt actttttcaa gcccgtggtg ctcttcgtcc aagagacgtc ctgcttcttt 2539741 caaatcaagc ttatcatctg tttcatccgt ccacggaaga gcaaccagcc agtcgatata 2539801 gttgcggatc acagagcttt ccgcagaact tgacggaatt ttttcatatc tgttcaattc 2539861 tttaagcgct gtttctttca catgatcagg catgcctgct tcttcgattt tttccgtcag 2539921 cgtctgaact tcgccagttt tgccttcttt atcgccaagc tctttttgga tcgccttcat 2539981 ttgttcacgc aagtagtatt ccttctgcgt acgctccatc gaacgtttga cgcgctggcc 2540041 gatttttttc tcaatctcca gcacttcttt ttcattatta ataaaatcaa tgaccttgtt 2540101 cagcctgtct ttgacatcag ccgtttctaa aatatcctgc ttatccttta gtttaagggg 2540161 cagatgagaa gcaacgatgt ctgccattct ccccggctct tcgatatcag taaccgcagc 2540221 gtacgtttcg gccgagattt ttttagaaat ttttatgtac tgatcaaagt ggtctagcaa 2540281 agtccgcatc aatgcttcgt cttctgtatc ttttgaatca tcttcatgaa taagttgaat 2540341 gtcaaccgac gtgtaatcct cgtgttcatt gtatttgacg atatgggcgc gcttgaggcc 2540401 ctccaccaac acacgaatcg taccgttcgg aagcttcagc atttgcttaa tttttgtata 2540461 ggtgccgaca gtgaaaatct cgtcttcacc aggttcgtct atcgaaatat cctgctgagt 2540521 ggctaaaaat atcatatgat catgcatcat tgcctgttca agagcctgaa ccgacttgtc 2540581 acgtcctaca tctaaatgca aaaccatcgt cgggtacact aataaacctc ttaaagggag 2540641 gagcgggatg ctgcgtttta attcttctgc catgtgactg acacctccgt gactttagta 2540701 tgaaccatta taatacaact ttttcatcct tgtacaataa acggcatggt tccattttct 2540761 ataaaacagt ctcctcgtag tatacccttt ctttctgata tgaaaaagga aaagatgtcc 2540821 ttcatgaaaa aaaccctatt atcaaaatag ggtttaaacg gattctttat tgatttcgat 2540881 atgaaacggt ttttgttccg ttggcggatt caccaaaatt tcatcaagca cttcttggaa 2540941 cgtcttcact gcaataatct cgatcccgtc aatctgcttt aagatggcct gctgattttc 2541001 atatgggata atcacctttt tcgcaccgga ctgcttggcc gcttttattt tcggaatgac 2541061 gcctccgatg ggtttcacaa gaccgttcag gctgatttcg cccgtcatcg caacggtatt 2541121 gtcaatagga attttgtgta tcgccgagaa aatccccgcc gccatcgcaa tgcctgctga 2541181 cggcccatca atcggaatcc ctcctgggaa attgatgtga atatcataat cagaaggctt 2541241 cattcccatt gtccggagca cggttaatac attttcaacc gaacccttcg ccatgctttt 2541301 tcgcctgatc gattttgatt ggctgccgat gctttcttct tcagctattc ctgtgatgtt 2541361 aattgatcct ttatcttgag ccgcggttac acttacttcg atttccagaa gcgatccgct 2541421 gttaggccca tagactgcaa gcccatttac aatgccaacc tgtggttcaa caccgatttt 2541481 ttgctcgtgc tttggagtaa gctgactgga gtgaatgacc cattcaatat cctcaatcgt 2541541 aatgtccttt cgattctccg ttacagccat ccccgctgcg atttgaatca tattgacggc 2541601 ttcccgcccg ttccgcgtgt agctggtcaa aagatccagt ccttcttcgg agatattttt 2541661 ttcaatttta tccgctgctg ttttggcaac cgttttcagc tcgtcctttt caagctcgcg 2541721 gaaaaaaacc tccaaacagc gggaccggat agctggcgga atttcgtttg gcattctcgt 2541781 ggtcgcgcca atcaagcgaa aatcagccgg cagcccattt tgaaaaatat catgaatatg 2541841 attcggaatt tgtgtatttt cctcactgta atacgcactg tctaaaaaga cttttctgtc 2541901 ctcaagcacc ttcagcattt tattcatttg aataggatgc agctccccta tttcatcaat 2541961 aaacagcaca ccgccatggg catgggtgac agctccctgc ttcggctgcg gaatcccagc 2542021 ctgtcccatc gctccggccc cttggtatat cgggtcatgg acagagccga tgagcggatc 2542081 ggcaattcct ctttcatcaa aacgggctgt tgtcgcatcg agttccacaa agacagcctg 2542141 ctctttaaac ggtgattgtt tatgtttttt tgcttcttcc aacacaagcc gcgcagcagc 2542201 cgttttccca actcccggtg gcccatagac aatcacatgc tgaggatttg gcccgcataa 2542261 agccgccttt aatgctttaa tgccgtcttc ctgtccgacg atatctttaa agcttttggg 2542321 gcggaccttc tcagataatg gctcggacaa gctgatagcg cgcattttcc gaagctgctc 2542381 catttccttc tttgattctt tatctatcgt gaccttttgt gtcctttgat ttttaagcaa 2542441 attccaaaaa tacaaaccga tgatgatccc aaaaaacagc tgaataaata acgcgatccc 2542501 tgtccaactc atggtggtcc ctcctgaaaa acaatttatg tatccaattc attcctctga 2542561 ttgctagtat ctcccataga agacgggaat aaacgttttt ccggaagagt tgcatgcaaa 2542621 aaaacctcct gagtgttacc actcaggagg tttgtgctta tctttatgca gatgttttat 2542681 cttggcttac ctcagtgccg tcttttaata agaggcgagg aggctctccg tgtgtcacag 2542741 ttgccccggt gattacacat ttttcaatgt catcacgaga aggcagctca aacatcacat 2542801 caagcatgat gccttcaatg atagaacgga gtccgcgtgc tccagtcttg cgttcaattg 2542861 cttttttagc aatttcagaa agcgcttctt cttcaaactc aagctcaacg ttgtcaagct 2542921 caagcatttt cttgaattgc ttaacaagag cgtttttcgg ttttgttaag atcgcaacca 2542981 atgcttcttc gtcaagcttt tcaaggcttg caataaccgg aagacgtccg ataaattcag 2543041 gaattaaccc gaaacggagc aaatcttctg gaagcacttt tgaaagaaga tcttctttct 2543101 caagatcagc agctttattg tcggcaccga atccaatcac tttttggcct aaacggcgtt 2543161 tgatgatttg ttcgatacca tcgaaagctc cgccgcaaat gaacaaaata tttgttgtgt 2543221 caatttgaat gaattcttga tgaggatgct tacgtccacc ttgaggcggt acgcttgcca 2543281 ctgtaccctc aagaatttta agcaatgcct gctgtacacc ctcacctgac acatcacgtg 2543341 tgatagacgg gttttcagat tttctagcca ctttatcgat ttcatcaata tagataatgc 2543401 ctttttcggc tttttccaca tcataatcag cagcttggat gagcttcaag agaatattct 2543461 ctacatcttc acccacgtat ccagcttcag tcaaagatgt agcgtccgca atcgcaaacg 2543521 gcacatttaa aatgcgagcc aatgtttgcg ccagaagggt tttaccgctt cccgtagggc 2543581 cgattaatga aatattactt tttgaaagct caacatcatc aactttgctg ttggagttaa 2543641 tgcgcttata gtggttatac acagcaacag caagtgattt cttcgcttga tcttggccga 2543701 tgacatattc attcaaaatt tcgcgaattt cctgaggctt tggtacgtct ttaaattcta 2543761 cttcttcttc tgttccgagt tcttcctcta caatttcagt gcagagttcg atacattcgt 2543821 cacatatata tacaccaggt ccagctacaa gcttacgaac ctgatcttgt gtttttccac 2543881 agaacgagca ttttaattgt cctttttcct cgttaaattt aaacattctt tcacccctta 2543941 atcttgtctc actttttctt ttaccggcag agcaaaagaa aatgattctt gaaacgaacg 2544001 agtatgtatt gcattttacc atactttcca aaaagacggt aacaatgtgt ttctgacttg 2544061 cacattctat atgtatgaca aaaaacagcc ctgcattaac tatattgccc caagaaaaag 2544121 agataactca taattgtaca aaacaaggca cgaatgattc gcgccctgtt ttattagtac 2544181 tattattatg caccatatta acggttttct acaagaaaat caattgcttt gcgaactttt 2544241 aaatcttctt tcatcgcgtc agtagaaccg atggcttgtt taatattttc aacaggcatg 2544301 ttgtatgctt cagccatttt tgtaagctca gcatcaactt cctcatctga tacttcaagg 2544361 ttttccgctt tcgcaatcgc ctcaagagtc aggttagatt ttacgcgttt ttcagcatct 2544421 tctttcattt gctctttaag cgcagcttca tcttggcctg agaattgagt gtaaagctca 2544481 aggttcatgc cttgcatttg cagacgctgt tcgaattctt tcagcatgcg gtcaagctca 2544541 gtgtcgacca ttgcttgagg cacatcgatt tcagcatttt cagaagcttt cagaacaagc 2544601 tcttcacgca atttagcgtc agcttcgttt tcttttgctt cttctaaacg tttctttgtt 2544661 ttttcagtta attcagcaag tgtttccact tcttcatcga tatcttttgc gaattcatcg 2544721 tcaagctcag gaagctcttt cgctttgatt tcgtgaattt tcactttaaa cacagctggt 2544781 ttgcctgcaa gatcttcagc gtggtactcc tcagggaatg tcacttcaac atccttctca 2544841 gcacctgctt caaggccaac taattgatct tcgaagccag ggatgaatga accagaacct 2544901 acttctagag agtagttttc agcttttccg ccttcgaaag cttcgccgtc aacgaatcct 2544961 tcgaaatcaa gaacaactgt gtttccttct tcaacggcgc cttcttcttt tacaacaagc 2545021 tcagcttgac gctcttgaag ggcttttagt tcgttttgaa catcttcgtc agttacagtt 2545081 gtgtcgtctt tttcaatgcc caggcctttg tattcgccaa gcttcacttc aggttttact 2545141 gttactttcg cagtgaagat taagctttcg cctttttcga ttttttcaac atcgatttca 2545201 ggacggtcta caggctcgat tccagcttct tcaaccgctt tagggtattc tacaggaaga 2545261 agaatatcca aagcatcttg gtaaagagct tctacgccaa agcgctgttc gaataatccg 2545321 cgaggaattt tacctttacg gaatccagga attgaaactt gttttactac ttttttaaat 2545381 gcatcatcaa gtgctgtttt aaacgtttca gcatcaactt caaccgttaa aacgccttcg 2545441 ttgccttctt gtttttccca ttttacagac atgtgtttcc ctccaaaaat ctattcaggt 2545501 tgtgtcggtc ttccattcta aagcaatcat tcggcttcgt ccaacaaaaa caaagctgcc 2545561 aaagatcaga atcattatgt atagatgtta ataatgaact gcaaagcctg tccaaccgta 2545621 tttcttataa cccgttatac acaaatacaa ccactatatt ataacataac acatagcgct 2545681 ttcaactata tggcgcgatt tacaaataag aaatttcttc aatatctttt aacattgtgc 2545741 aagcttcatc gagttctctg tctgtaaatt catacatcat atgaagttct tcgctttcaa 2545801 tttcaatccc gtgcatctcg taaccgactt tatgaagggc agccgcccaa aggtcagccg 2545861 acagcaattt cggctggaac ggatataaaa cgtacaaatg tcttctccac aattcttcta 2545921 ctgctgcata taaggttgga ttttcatttc caagtgtctc atctagcacc ctgagaacac 2545981 ggtgaagaat cggcgcggca tcaggcggaa caatctctga cggttcaatt gtcaacgact 2546041 cgccaaattt actaatgtgt acaggtttac tgtactcatg ctcagccaac agcatgacaa 2546101 tcatcgtttt gataatcgga tgggctgagg ggtcttggag gattgttttg agcaatcctg 2546161 tatactttgc tacgttacgg tcttttaagg aatgaatgag attcatttgc tcctcagggc 2546221 ttgccagcac tttctcggtg tcaattgtat cctcatattc ttcggcccaa gcctcgtcct 2546281 cacgatccgg atcggtcatt ttccggctga aatccagcag cttataaaat tgctcggcac 2546341 tttctgccgg cagctgattt tcttccaaaa cggcttcaat ggtgcttttg acttcttcgt 2546401 actttttgag ctgaattaag atggtcatgt acacctgcaa aaccgtaaaa taatggccat 2546461 aaccttcttt gagcatcttc tcgcacacgc tttctgcctc ttccagctcg cccagctcta 2546521 aaaagcagat ggccatccct aagtgaagat cggattcagt atcatcatat ttcatcgctt 2546581 ctgaaaacag ttcaagcgct tcttgatact ttttttcctt gagtgatgac atcccttttt 2546641 ccacaaggcg gtctttcaga tgaggaaaag gaataatttt tgcgtttttc ttgtcatgcg 2546701 tcatacctat attcctttca ggcatttatt ttgttcaagt gtatcaacac ctgtgaacaa 2546761 aaacaagaaa tgaaaggttt caccaggcaa aaaaagccgc cggacaaata ccggccgctt 2546821 tttcaggctt gaagccaaga gcttctttgt gattcaaatt gcttgatttc atcttccagc 2546881 agcagcgtta atgaaatttc atcatatccg ttgatcagca tctctttcca atgcggatca 2546941 acttcaaatg aaatttgatt gccttcactg tcatgaatca gctgattttc aaggtcaaca 2547001 gtcatttgca atgactggtt ttcatactgg ccgacaagct gtttccaatt gtcatatggc 2547061 atgcggatcg gaagcatgcc gtttttaaag cagttctgat ggaaaatatc agcgaatgac 2547121 ggcgcaatga taattttaaa cccataatca tcaagtgccc acggagcgtg ttcacgcgat 2547181 gacccgcagc cgaagttttc tcctgctatt aaaatggaag ctccttgata aacaggctgg 2547241 tttaattcaa attcagggtt cggttcacca ttcgcatcat atctccagtc aaagaatgca 2547301 aaacgtccgt agcctgttct ttcaatcctc ttcaaaaatt gcttaggaat aatctggtct 2547361 gtatccacat tgatccgatt taatacggct gctttccccg tatgtgattt caaaggttcc 2547421 atctcgcgca ctccttacac aactgttttt tcctgataaa actttctgac atcaacgaag 2547481 tgtccgtgaa tggcagccat cgcagccatt gccgggctga cgagatgtgt tcttgcacct 2547541 tttccttgtc tgccctcgaa gttgcggtta gaggttgatg cacagcgctc tccctcagga 2547601 acaacatcat tattcatact caaacacatg ctgcagcctg actctctcca ttcaaatcca 2547661 gcttccaaga aaatctggtc aagcccttct ttttcagcct gaagcttcac gctttgggat 2547721 ccgggcacga cgatggccct tacgctgtca gctaccttct tccctttgat catgtcagca 2547781 gcctgtcgaa ggtcagtcat gcgggaattt gtgcaggaac cgataaatac gtgctccact 2547841 ttaatgtctt caattttttg gtgaggagtc aatcccatat attcataagc acgaatcgct 2547901 tcttttttat cgtcttctgc agaaaagctt tccggcgcag gaacttcaga atcgacagga 2547961 agaaccattc ccgggttaat gccccatgtc accatagggg aaattttgtt gccgtcaagg 2548021 acgatagatt tatcgtaaac agcgcccggg tctgtgcgca gcgccttcca ttcctctacg 2548081 gccttgtcaa attcttcgcc ttttggcgtg tacttgcgat ttttgcaata ttcaaacgtc 2548141 acctcgtcag gtgcaatcaa acctgctctt gctcctgctt caattgacat gttacaaaca 2548201 gtcattcgtt catccatcgt catatttctg aatacttccc cagtgtattc aatgacgtag 2548261 cctgtgccga atttcacacc gtatttgccg atgacagcaa ggatgacatc ctttgccgtt 2548321 accccttttt gaagcgttcc atctacgcgc acttcaagtg tttttggacg ctgctgccaa 2548381 agtgtctgtg tggaaaggac atgttcaact tcactcgtcc cgattccaaa tgcaagagcg 2548441 ccgaaagcgc catgtgttga tgtatgactg tcaccgcaca caatcgtttt ccctggaagc 2548501 gttaagccta gttcaggtcc gacgacatgg acaatccctt gatccacact gtgaagatcg 2548561 gcaaggcgca cgccaaattc ctcacagttt ctttcaagcg ccgttacctg gcgtttcgca 2548621 acttcatcct ttatctcaaa acgattgaca gtcgggatgt tgtggtccat tgtcgcaaat 2548681 gtgttttggg gtcttctgac ctttcttccc ttttgtctca agccttcaaa tgcctgagga 2548741 gacgtcacct catgaatgag gtgcaaatca atatagagaa gatccggctt tccctcacca 2548801 tgttttacaa tatgctgatc ccaaatcttt tcgatgattg ttcgaggcat catcttttat 2548861 ttcctccctc tacctagagc taagaccgct taacgtaagc tgtcacacat tagaaattgt 2548921 attttcactc atgattgctg ccttaacttc ctctgtaatg gcctgagtgc tgctgaactc 2548981 ttcactccgt gccaagtctc ttgttctttt tccagaagcc aagactttgt ttaccgcatc 2549041 ttctacagct ttcgcttcct cttcaagccc gaaagatgtt ctcaaaagca ttgccgctga 2549101 caatatggct gcgaacggat ttgccatccc tttaccggca atatcaggcg cggagccatg 2549161 aacaggttca aacagatgaa ggccagagct tgataggctg gctgacggga gcattccgag 2549221 cgagcctgta agcatggacg cttcatcgct taaaatatca ccgaacatat tttcagtcac 2549281 cacgacatca aattgattcg gtgcataaat tagctgcatg gccgcgttat ccacaagcat 2549341 gtgctcaagc ttcacatcag gaaattcttg tgcaacgtcc tcagccactt cacgccacag 2549401 ccggcttgat tcaagaacat tcgctttatc tacagaggtc actttgcctt ttctggctgc 2549461 cgccattttg aagccctctc tgatcactcg ttcaatttcc gttcgcttat aaaacagtgt 2549521 atctactgct tcctgctcac cttcagtgtt tacataacgt ttgctcggct ggccgaaata 2549581 caagccgcct gtgagctcac gaacgataac gaaatcaaca ttatctatat attctttttt 2549641 caaaggcgaa gcgtcagaaa ggctttcaaa taccttcaca ggccgcaaat tcgcaaacaa 2549701 atcaagctgt tttctgatgc tgagcagccc tttttccggt ctcagttccg aaggattttg 2549761 atcccatttc ggtccgccga cagcaccaag caatatcgcg tctgcatttt tacaagcagc 2549821 aacggtttcc tccgggaggg ggttatgatg ttcatcaata gccgcccctc caatcaggcc 2549881 atattcaaat tcaaattcat ggttaaagcg ttcggcaaca cttttcagta cgtctgtcgc 2549941 tgattctaat acttcagggc cgatcccgtc tccgggcaat agagcaatac gtttcttcaa 2550001 gttaaccgtt ctcctttctt ttatgatccg acagctgtgt ggtttttcaa tccgctcata 2550061 ttcgactgga aaaccaattg acggtttact gcgttcaaat aggctttcgc tgatgcttct 2550121 aatacgtctt gcgctatgcc ccgccctgct gattcttttc cgttcaccaa aactcttaca 2550181 tacacctggg caaatgcatc ttcgcctttt ctattagact gaatgcggta gtctaagagc 2550241 tccacatcct tatcgatgca gcgctcaagc gtattgtaga ttgcttccac gcttccagct 2550301 ccagttgcag cttcctgaat aagctgtgcg ttttcttgat ttttcaaaga tagagtagcc 2550361 gtagggacct gacttgttcc gtaatgtact tgcagagaaa gaaattcata cccaatcttg 2550421 cgatctgtta ctttttcttc taaaataaga gaaacaagat cctcatcagt gatttctttt 2550481 ttcttctcag tcaactcttt gaacatcgta aagaatttat taatctcttc actgtcaaat 2550541 tggaatccta aagcagtcag ccggtcttta aatgcgtggc gtccggaatg tttacctagg 2550601 acaagcgcat ctgcggttac gccgacaagc tccggtgaaa taatttcata agtcgatttt 2550661 tcctttaaaa agccgtcctg atggatgcct gattcatgag caaatgcatt atctccaaca 2550721 accgctttgt tgcgcgggac agccatgcct gtcagtttgc ttactaaatc acttgttctc 2550781 ttaatctcgt tcagcgtaat acctgtttcg acttggtaga aatcttttct ggtatggagg 2550841 gctacggcaa tttcctctaa tgccgcgttt ccggctcttt caccgatccc gttcacagcg 2550901 cattcgattt gatcagcgcc attttcaatc gcagcaagag agtttgcgac tgccattccc 2550961 aaatcatcat gacagtgggc tgaaagcttt gctttgtgaa tgttcggaac gttttctttc 2551021 atatatttaa agatatttcc gtattccgcc ggggccaggt agccgacagt gtccggaaga 2551081 ttgataacac tggcgcctgc gtcaatcact ttctcgacga tttctgctag aaacggcagt 2551141 tcagtgcggc aggcatcttc agctgaccat tgcacaatcg gaaaacgttc ttttgcgtat 2551201 ttcaccattc caactgctct ttcaatgact tgttcacgtg tcattttcag cttgtgcttc 2551261 aaatgaatgt ccgatgtcgc gataaataca tgaattcttg gttgagcgcc atcctttaac 2551321 gcttcccaag cagcatcaat atcacctttt acacaacggg ccagaccagt tactgaacaa 2551381 tttttaatgg ttcttgcgat ttcctgaaca gctaaaaagt cacctcggga cgaagcggga 2551441 aatcccgctt caatgatgtc tgccccgagt ctttcgagct gcttagctat ggcaagtttc 2551501 tcctgtgtat tcaagttcac tccaggggac tgttcaccat cacgaagcgt cgtatcgaaa 2551561 aaattaattt tgcgcaacgg agaccaccgc ttccttcttc ttgccttgtt tcacaaacgg 2551621 catcatttca cgaagctttc ttcccactac ttcgatttga tgttcgttct cgcttgcatt 2551681 gatagcgttg aaacgaggac ggtttacttg gttttcgacg atccactctt ttgcgaatgt 2551741 accgttttgg atatctttta atacttcttt catagattct tttactttgg cgtccacaac 2551801 gcgagggcct gatacgaaat ctccccactg tgctgtgtca gagattgaat atctcattcc 2551861 tgcaagtcct tcttcgtaca taaggtctac gattaatttc agctcatgaa gacactcgaa 2551921 gtatgcaagt tcaggctgat aacctgcttc agttaaggtt tcaaatccgg ctttgacaag 2551981 cgcgcttaat ccgccgcaaa gaactgcttg ctcaccgaac aaatctgttt ctgtttcttc 2552041 tttaaatgtc gtttctaata cgcccgctct tgcgccgccg attcctttag cataagcgag 2552101 ggctttgtct cttgcttctc cagtcacatc ttgatagatt gcgaacaatg caggtacgcc 2552161 agctccttgc tcatatgttc ttcttaccaa gtgtcccggg cctttagggg ccactaagaa 2552221 tacatctaca tccgccggag gaacaatttg atggaaatgc acgttaaatc catgagcgaa 2552281 tactaatgat tttcctgctg tcaattcatc tttgatttca gcttcgtata ctttttgctg 2552341 ctgctcatcc ggaagcagaa ccatgatgat ttcggcttgg gctgccgctt cttttactga 2552401 aaatacttta tgtccgtctt cttgggcttg agtgaaagat tttccttgtc taacaccgac 2552461 gatcacgtct actccgcttt ctttaaggtt cagggcatgt gcgtggcctt gcgaaccgta 2552521 cccgataacc gctactgttt ttccagccaa tacgttctct ttgatatcac cgttataata 2552581 tacttttacc atttcaatct ctcccttgtt atgttttata caatagatat tgttttattg 2552641 gatgacgcct tttgctgggt tcccctcgca aaagccgttg tacctgttct cgcgatttct 2552701 ttaatgccat aaggttttaa taactcaata agcgcttcaa ttttgttaga ttcacctgtc 2552761 acctgaacaa cgatgctgtc tctgctgaca tcaacgacag aggctctaaa cggttctatg 2552821 attccattaa tctctgttct tgttgaaggt gcggagacaa ccttgattaa ggccagctcc 2552881 ctctggacaa tcgattgatt tgtgatgtct gtgactttca gcacatcaat ctgtttgttg 2552941 agctgtttcg ttaactgttc aacatcattt tcaccttcaa catgaacgac gaaggtgatt 2553001 ctggaaacgc cggctgtttc tgtgtgtcca actgtaatgc tttcaatgtt gtaatgcctt 2553061 tttgtgaata gaccggtgat ccggtttaac accccggagc ggttcaccac agtcaatgtg 2553121 ataattcttt tcaaggtttc acccccacca tttcatgcag ccctttcccc ggagccacca 2553181 tcgggaatac tttttcttcg ctggcaaccc gcacgtcaat gacaacaggt tctcttgatg 2553241 ttaatgcctc ttccagcttt tcctttgctt ccgcttctga tgaaattctg atgcctttaa 2553301 tgccgtatgc ttcggacaat ttgacgaagt caggctgaga agcgaattta gattctgaat 2553361 aacgttcttc atagaaaatt tcctgccact gtctgaccat tccgagacaa gcgttattta 2553421 aaatcactac cttgaccgga agatttaatt cgcgaataac atcgagttct tgaagcgtca 2553481 tttggaatcc gccgtctccg acaaccgcga caacagtagc atctttttcg gccagctgtg 2553541 cgccgatcgc cgccggaaga ccgaatccca tcgttccaag tccgcctgac gtgacccatt 2553601 tatctgcttt ttggaacgga taaaattgcg ctgaccacat ttgatgctgg cctacatccg 2553661 ttgcgacaat ggcctctcct tttgtaaatt gatgaatata ttcaatcaat ttctgaggtt 2553721 taaaaccttc ttcttcatta tctacatacc agagcggata ctcttctttc cattctgcga 2553781 gctgtttttt ccattcgctt gaatcgcttt gtttgccgtc ttgtttgatc agctcctgca 2553841 ggacaatttt gctgtctccg actacaggaa tctgtgtttt catgattttt ccgatttcag 2553901 ctggatcaat atcgatgtgg gctatctttg cgtttctggc aaagtgtttc aggtttcctg 2553961 tgacacggtc atcaaaacgg gcgccgatac tgattaatag atcacattca tgaagggcca 2554021 tattggctgt ataagtaccg tgcattcccg ccatccctag gaaaagcgga tggtcagccg 2554081 ggaagcctcc gagccccaaa agggtgtgtg ccacagggat ttgctgctgt tcagcataat 2554141 tttttaattc ttctgacgct tttccgtgca gtacgcccgc acccgccagg atcaccggtt 2554201 ttttcgcact gctcacggct tccacaagct tgcggatctg caaataattc ggctctgttg 2554261 tcggctggta tcccgggaga ttcatctcat gatcgtagct gaattctcct tcaattgttg 2554321 ctacatcttt cggaatatca atcaatacag gtccgggtct tccagttgtt gcaatatgga 2554381 acgcttcttt aatgatgcgc ggcagatctt ccggctggcg aacctggtag ctgtgttttg 2554441 ttactggcat cgtaatccct aaaatgtctg cttcctgaaa tgcatcgctc ccgattacag 2554501 aggttgctac ctgccctgta aagacgacta acggcaatga atcaatcatg gcatcagcaa 2554561 ggcctgtaac aaggtttgtc gctcccggcc ctgacgtggc aatgacgaca cccggttttc 2554621 cggagaccct tgcgtatccc tccgctgcat gaattgctcc ttgttcgtga cggggaagga 2554681 tatgtaccaa ccctgaattg tatagcttat cgtaaatcgg aagcacagcc ccgcccggat 2554741 aaccgaagat catttctact ttctcttttt ttaatgattc aatcagcatt aatgctccgc 2554801 tcatcgtctg tgtacattcg gcagatgctg aatccacctg tacattagtc cccattttag 2554861 ttcctccttt tggattttca tcctttaaag atcatctttt cattagctag atagctgatt 2554921 attcaataaa aaaagccctt ccgcccacaa tcagccgcgc agtaactgcg atagctaaaa 2554981 ggggcgaaaa ggcttttctt tccgcggtac cacccttgtt tacggcctgt taatcggccg 2555041 tctcatggat atttctatcc gctttagtaa cgagtgaatc aagttcaccc ggccaagtcc 2555101 tactgtcatt tcagactggc actctgaggc gagttcacct tgtaaagctt cgccggttct 2555161 cagctaaccc ggttctctgt ggaaaacttt atcaaggcta cttatcctca tctgcgcttt 2555221 tcatattcag ccttcggaac ggctttccag ctgttcaaga aggtcgtttg tttttcattt 2555281 ttttagaatc atactgcgat gattttcgct tgtgaagctt gcatttatct tttgttgaac 2555341 tcatattacg ccgctttgga cgcagtgtca acagcatttt ttaaaattat tagacaattt 2555401 tgattaatca atctatattg tatacgcttt cattattggt acaaaaggaa ttgcaaatgt 2555461 taaaagtttt tataattttt ttattaatct atcaagaata caccagaatt atttaatttt 2555521 atataaacat ggaagatttt ataacacgat atggttcgta tatggattga gtctgacaga 2555581 tcatcttgca atccatttca atttcggata ggcacttctc ttgttccctc ggcatacatt 2555641 aatgatatct tgcaaagaaa aggtgatacg atgaataaat catttgcaga catgcaagga 2555701 tttcctgcgg gctttccaag cttccccaac tttccgcagc agtactatcc tgctgtccct 2555761 cccttttacc agcaaagcca gcagccattt ggaggctacg gatacggaca gccgttcagt 2555821 caggcataca gcccgttaac cactccctct ggaatgtact cctcattccc atacgcttca 2555881 ggattttacg gacagcaatt ttcaggtgca ggctttagcg gccatggcgg cagcttaagt 2555941 gctccagcga tacatgccgg cggattcagc ggggcgccag gcgtacacgg aggctttaga 2556001 tattaaagaa taccacaagg gccgaacatc tattgcggtc cttttattgt tttaaaacga 2556061 cttcacaagt acagtcacat tttctgtctt tatatttgga aacaggatgg aatatgatta 2556121 agatgaattg aacgatattc tgcacaatcc gtaagttttc gaggaggaat aaaattgcat 2556181 ataaaaatag acgatttaac tggacgtcag gtggtttcac tggtgaatga gcatttacat 2556241 agcatgacgc ttatgtcccc gccagaaagc attcatgcct taggtctaga aaaactaaga 2556301 gggcctgaaa taacattttg gagcgcatgg gaaggtgatg aactagctgg ctgcggagcg 2556361 ctaaaagaac tggacacccg gcatggagaa atcaaatcaa tgcgaacatc tgcatcacat 2556421 ttaagaaaag gcgttgccaa acaagttctc cagcacatca ttgaagaagc cgagaagcga 2556481 ggctatgagc ggttaagctt agaaacgggt tcaatggctt catttgagcc ggcaagaaaa 2556541 ttgtatgaaa gcttcggttt ccagtattgt gaaccgtttg cagactacgg tgaagatcca 2556601 aacagtgtgt ttatgacgaa gaaattgtga gacggcttta taaggataga taagtgcagg 2556661 ggaaggtctg tcttatctat ctttttttat attcacacat ttttcacctt tatgatacac 2556721 gccaatgttt tcaattttgt ttaattcaaa gaacagcggg aattacaaac gacatgaacg 2556781 atatcatgca aattcataaa ggaggagatt gatatgaaaa gcatagttgg tgtatatgaa 2556841 actccgcagg aaaccatcgc agcgattgaa ggcttactta caaaaggcta tgattctgat 2556901 gacatttctg ttgtgacaag ccggcgagat acagattatt tggagtcacg tacaggaaca 2556961 gaagtcaatc aagctatcga tgcacatcag gacgaatctg aatctttttt cgataaactg 2557021 aaagattatt tcacaatgga tgatactgct acacacagca aagcattatc cgacttggat 2557081 attaaaactg atgaaataga caagtatcaa gaagatttgg atgacggaaa acttctggta 2557141 gccgtcgata cagatgcaga tgtaattgct cctattgata acggcaatgc cctttcaggc 2557201 ggcttttcaa gcacaaatga attggattat acaacgaaag aagaaaaaac gatgccgctc 2557261 cgggaagaac agctgaaggt cgataaggaa gacgttcaaa ccggcgaagt agaaatagga 2557321 aaagaagtga aaacagaaaa aagagatatg gacattccgg tgagacatga tgaaatttat 2557381 gtcgaacgcc gtccagtgga tgaaaataaa acggacgctg ctcccgtcaa cgattcggaa 2557441 gagatcagag ttccaatcgt tgaggaaaag ctggaagtga ctaaaaaacc ggttgtcact 2557501 gatgaagtgg ttgtcggcaa acgcactgtt gaagaaaatg aacatatttc tgaaactgtg 2557561 aaaaaagaag aacctcgtct gaataaagaa ggaaaagttg acggcttgga tgatgatccg 2557621 ttaaataaca aatgaaaatc atagaccgac aacaaaaaac ctcaaatcct aaatggattt 2557681 gaggtttttc ttttggtacg tcccaggaga gattcgaact cccgaccgac ggcttagaag 2557741 gccgttgctc tatccagctg agctactggg acacgttttg tttttttgtt tttcgcttta 2557801 actatcagcg acaagattta ttatatatgg gatgcaataa taagtcaacg gttttttaga 2557861 atttttttca tgaggaagaa aattttcttc ctcatgacat tttcatagtg tgactcgatt 2557921 ttgcagatcc tcaatttcat tgcctgcttg gtcgtaaaaa cggactgtcg cagcatcatt 2557981 ttctaatgtc agtatagcat agctttctgt cctgcgcacc ctcggaagcc ggatgctgcc 2558041 tgggttaatc atcagttttc cgcgcagcac ttcgcttccc gcgatgtgcg aatgcccgaa 2558101 gcagataaca tccgccccga gctcctctgc acgatagtat acgtttaaca aggtctgttt 2558161 tataccgtga aggtggccgt gtgtgactag tatttttctt gagccggcag tcagaagaag 2558221 ctcgtcctta aaatcgccgg caaaatcgca attgcctttt acaaccgcat aaggctccaa 2558281 tgcaggatgc ctcgtctcaa gctcagagtc cccgcaatga atcatgagat caacttctgc 2558341 ctcatgccgt ttcgcaatgg tttggagttc ttcttcaagc ccatggctgt cactgataat 2558401 cagcacgttc atgtacaagc ttcctcctta tgcctccaaa agcttagaca gctttttaag 2558461 cgcgtcagcc ctatggctga ttttattttt ttcatcactt gtcagttcag ccatcgtctt 2558521 atctttatct ttcacgataa aaattgggtc atagccaaag ccatattctc ctctcggttc 2558581 ttcagcaata tacccttcaa catggccttc gactgttttt gtttcctctc cgggaatact 2558641 cacggccagt gcgcagcgga aacgggcggt gcgctgttct ttttcgatac ctttcagctc 2558701 gctgagcact ttttcgatat ttgcctggtc gtctttctgt tcccctgcat agcgggctga 2558761 ataaaccccg ggtctgccgc caagattatc gatggatagt ccggagtcat ccgcaatcac 2558821 cattttgttc actgctttgg caacagcttc cgctttcata atggcatttt cttcaaatgt 2558881 atggcctgtt tcttcaattt cctctgtgaa tccaatttca gctaaagatt tgacatcata 2558941 gcctcttggc tcaagaattt ctttgaattc cttcactttt cccggattat gtgttgcaat 2559001 aattgcttct ttcatgatga tcaagccttt ctgtctttat ttcagttctg gcagagaatc 2559061 acccagcact tctttttgct tgtcaatcag ctcttggatt cctttttccg caagacccag 2559121 aagaccgttc agatcctctc tagaaaaagt tgcctcttcc ccggttccct gcaattccac 2559181 aaaacggccg ctgcctgtca tgatgacatt catgtcaact tcagcagagg aatcttcttc 2559241 ataatttaaa tctaacaaaa ttccctgttc cttatcaatt ccaacagaga ttgcagcaag 2559301 aaaatcagtg atcggatttg tcttgattgt tcctgctttg atcagcttgc caatcgcaat 2559361 cgccatagca agaaatgcgc ctgtaatgga agctgttcta gttcctccat cagcttgaat 2559421 gacatcacag tcaatccaaa tcgtccgttc accgagcttt tccagatcta caacagctcg 2559481 aagcgcgcgg ccgatcaggc gttggatctc cattgttctg ccggaaattt tccccttaga 2559541 agattctctg attgttcttt ggtttgttgc ccgcggcagc atgctgtact ctgctgtaat 2559601 ccagcctttc cctccgcccc gcaaaaacgg cggtacgcgg tcctcaacag acgcgttgca 2559661 gattaccttt gtatttcccg ctgttattag aacagaacct tccggatggc tgataaaatc 2559721 caaatcgaat gtgattggac gcagctcatc gtgttgtctt ccgtcatgtc tcatgtttta 2559781 cctccgattg tatgtacata aaccattttt gtcccggaat tgaataaaga aagaggcagc 2559841 cggaacgcta acctctttct tcctagtata tcaaaaatcc caatttaaaa actacccgta 2559901 ttcacttgag atggtctgga gaccggttct gtgagctttt cgcctttttc atttaccagc 2559961 tctgattttc cgttcacttt aacagagacg ctttttacat ccggctgctc cgttaacgtc 2560021 agcacaatgc tgttcagcac ttctgaagaa atcattttcg tcttctcatc ggcgctgccg 2560081 aatatagatt gattgaaatc caacgtcacg cgcccgtctt tgattttcgg tttgctgacc 2560141 agctttacat cttcactgaa gtctgttaac agcccgctca ccttgctcgg ccctttagcc 2560201 aattcattaa tggctgctgt gatgtcgtct ttttccgaat tgtcgattcg tttggtcacc 2560261 ggcacgtagt attcactgtc ttcattttcc gccaaatagt agactgtcag cggatgggta 2560321 gcagtgagat catttacacc ggctgtttcc aaattaatgc cgtctttgcg gcttaaatca 2560381 tctgagatcg gcgtccctcc tacaggcatc tccttcagtt catgcccgtt tattctcagc 2560441 ttcactttat ctatcgaact aaattgcgtc agcgtccacg tcacagattg aacgattttc 2560501 tgttcgtctt ctttcttata atttttgaac tcattagaga aatcagctat cgccgttcca 2560561 tcttttttga tgtcaacgtt aacggtggtg tcagccggca atacagctct gaagccattc 2560621 ggaagaattt cagacacagg cccgccctgt acgaggtatt caagcgcctg cttagccgtg 2560681 ctctcacttt taggaagagg cagcgtttgc gcaacaacat acccgttttt atcaatgaga 2560741 taaagctccc tcataacagt agatgaggct tgatccgctt ttgcggtatc gcttttttca 2560801 ctttctgttt ttttggctgc tgttgtattt gaattggcac ccgcttcatc gttcacgaat 2560861 gtaacgtctt gaggcggatc aatttcctcg gctgccttat cagattgaaa caaaccgcat 2560921 ccggataaaa gcaaggcaga ggtgagacaa gtggcaccaa tgactgcagg tccttttttc 2560981 agcatacttt tccctcctaa ggatgtttgt actattatgt atacgagcct ctttaggaaa 2561041 tagaccgaag aattccggca aaacagaaaa aaacccgcaa cataccgttg cggggaaaac 2561101 tatcttttaa tcggttcttg cagtgagata cattccacat gcccgacttc atggccaaac 2561161 caatcgtctg cgatttttgc aaactgatca cgcgcccctg ttgtcaggaa ctgatgatcc 2561221 ggggcaatcg gagactggtt cagcagccct ttataagaga gaattgtgct gacttcccgg 2561281 gctgtttcat cgccggacga aataatgttt acgtgctctc ccatatatct ttgaatggct 2561341 tcttttaaaa tagggtaatg ggtgcagcct aaaatcagcg aatcaattga tgtgtctttt 2561401 aacggataca gcgaggtttt aacaatctcg tctgctgttt tgtcgagaaa cttcccgctt 2561461 tccacaaaag gcacaagcag cgggcaggca aggttttcaa ccttcaaatc agggtttaat 2561521 gccaaaagcg cttcttcgta tgcattgctc ttaatcgtat tctctgtgcc gatgacaccg 2561581 atatgctgat tatccgtcac ttttatcgct gctctcgcac caggctggat gactccgacc 2561641 accggtatac cgacgctgcg ctggatgtca tccaaagcga tcgctgttgc tgtattacag 2561701 gcgatcacga gcattttgat gtggtggttt tcgagtaaat aattcgtcag ctcccacgta 2561761 tattgaagca cctcttcttc agggcgcggc ccgtaaggac accgtttcgt atccccgacg 2561821 tagataatat tttctttagg tagctgtctc atgatttcct tcgcaacggt taaaccgcca 2561881 accccggaat caatgactcc tattggttgt tccaacaaaa tcgcctcatt ttctcttcat 2561941 ttcatgctgc agtttcatca aagatttttc gaagatggct atttcttcat ctgtaaacga 2562001 ttcgaacata tcacgcagat attcctgtct ttttgtaatg acctcttgga taatccgttc 2562061 tccttcaggc agcagatgta tcctgacaac acgtctgtcc gccgggtcct tgacccgctc 2562121 aacaagctca tttttttgca tgcggtcgat taagtccgtt gtcgtgctgc atgccagata 2562181 cattttgccc gataattcac cgattgtcat atctcctaat tcataaagcc attgcaagcc 2562241 gacaaattgc ggcggcgtaa tcgcatattg gttaaggatt tctcgtcctt tttgcttaat 2562301 gatcgcggca atgtggcgga gtgacttttc aatatccgca acatgctcca aaggttttga 2562361 tgtcatttgt ccatccctca ctcaaggatc tcttacgcac aaaagcgttc cgtgtctatt 2562421 ttccttcttt tttgaagaaa atgcaagact cgcaggagag aaatagagga ctttagtcaa 2562481 acaacatcaa gaaataaaat ttaatttatg acttgcctac gttttgcaca gcattccaaa 2562541 tatggtttcg aatgttccaa acaaacagca ataaccggct ccttccaaaa gaaggaatac 2562601 cggcaaggat taaagctcta gctcacccat tctaagaagc tcaacaacgg cttgcgaacg 2562661 ccctttcaca cccaatttct gcatggcatt tgaaatatgg tttcgaacgg ttttctcact 2562721 gataaatagc tcgcttgcaa tctcctttgt tgtcttatct tgaacgagca attcgaacac 2562781 ttctctttct cttttcgtta gcagcggctt cgattgaaat tctttctcct tcaagtattg 2562841 taaccctcct tgctaaggtg agagcgaatc agaaacgaat gggttttgat atagtcgaga 2562901 tatcatatgt aagaagggcg caggaggtga cgtttacaag ataattagtt tatcgtgtat 2562961 gaagaagcgt ttctttctcc tcatccgtcc agctgacagc cttgccgctt tcctttgaga 2563021 cttgaaccat cacgactgcc ccggtgaagc agggttcgcc ttcgaggttc tctccgagat 2563081 agtgcaaggt aagagatgaa ctgccgactg cgcttgtttt cacatagatg cgcaactctt 2563141 cataaggcat gacttggcgc aaataatcgc attgctggct tgccacgact gtcatggtct 2563201 gtttgttttc actcatcata ttcagctttt taaaataaga aatccgcacc tcctcaaaat 2563261 atataaaagg ggttacatta ttcatatgcc caaacatgtc tgtctcggaa aatcttacgg 2563321 ataccttatt gaaaaaagaa aaggatgttt tccattcttg aaacggcata tcaatataag 2563381 cgggaagctt catctttttt catctcctta ttgtttaaaa aaacctctcc catgcggaag 2563441 aggttttttc ttcttatact ctgtcgcttc cgaagaaatt gcggaacgct tgtaagtttg 2563501 tatctctatt caaggctgca atcgaagtgg taagcggaat ccccttcgga caggattgaa 2563561 cacagttttg cgagttgccg caatctgcaa ggccgccttc atccattaat gcttctaatc 2563621 gttcagattt attcatggcg cctgtcggat gcgcgttaaa caggcggact tgcgacatcg 2563681 gtgcaggccc catgaacttc gatttgctgt tcacattcgg gcaagcttcg aggcagacgc 2563741 cgcatgtcat gcattttgat aattcatatg cccattgacg acgtttttcc ggcattctcg 2563801 gccccggtcc taaatcgtac gtaccgtcaa tcggtatcca cgcttttact tttttcaatg 2563861 aatcaaacat tctgctgcga tcaacctgca aatcacgaac gactgggaat gttttcattg 2563921 gttttaaacg gattggctgt tcaagctggt caataagcgc cgtacaagac tggcggggtt 2563981 ttccgtttat aaccattgaa catgcgccgc atacttcctc aagacagttc atatcccatg 2564041 tgacaggggt tgtcttctca cctttgacat taaccggatt ccggcggatt tccatcagag 2564101 cggaaatgac gttcagattc gggcggtatg gaatctcaaa ttcttcatca taaggcgtgc 2564161 tgtcagctgt atcttgacgt gtgataataa atcgtatggt tttttgttca ctcatgatta 2564221 tttcgccacc ttcttcttcg agtaatcccg tttccgaggc gttatcagtg atacatcgac 2564281 atcctgatac tcaaattccg gcgcttcata cgggcttaca tgtttagcca ttgttgtttt 2564341 gagccattca tcatcattac gttcaggata atccggttta taatgggcgc cccggctttc 2564401 attacggttg tatgcgccaa gggtaatcac cctcgcaagc tgaagcatgt tcgagaactg 2564461 gcgtgtgaac atcgctccct ggttgctcca ttttgtcgtg tcattgatgt tgatcttttt 2564521 gaagcgctcc attaactcct gaattttgtc atccgttttc aaaagcttgt cattatggcg 2564581 gacaaccgtt acgttcgccg tcatccactc accgagctct ttgtgaagaa cataggcatt 2564641 ttcggttccg tccatactca taatatcagc ccatttttct tcttctttct taacgtgagc 2564701 gtcgaataaa gatgaagaca tgtcttccgc tgaagattct aagccgttta catatttcac 2564761 cgcattcgga ccggccacca tgcctccgta aatcgcagac agcagggagt tcgctcccaa 2564821 gcggttgccg ccgtgcatag aataatcaca ttccccagcc gcaaacagtc cagggatatt 2564881 tgtcatttga tcgtaatcca cccataaacc gcccatagaa taatggaccg ccgggaagat 2564941 tttcattgga agcttacgcg ggtcgtctcc catgaatttc tcataaatct caatgatgcc 2565001 gccaagctta atatcaagct ctttcggatc tttatgagac agatcgagat ataccatgtt 2565061 ttcaccgtta ataccgagct tctggttcac acacacatca aatatttcgc gtgtcgcaat 2565121 atcacgcggc accaggtttc cgtatgccgg atatttttcc tccaggaaat accatggttt 2565181 gccgtcttta tatgtccaca cgcgcccgcc ttcaccacgc gctgattcac tcatcagtct 2565241 tagtttgtca tcgcccggta tggctgtcgg gtggatttga atgaattctc cgtttgcata 2565301 atacgctccc tgctgataaa cgattgacgc agcagatcct gtattaatca tggagttcgt 2565361 tgattttcca aagatgattc ccggtccgcc cgtcgccata atgacagcgt ctgaacggaa 2565421 ggattcaatt tgcatgtttg tcaggttttg tgcaacaatt ccgcggcagg ttctgtcatc 2565481 atctaaaaca gcgccaagga attcccagcc ttcgtatttt gtgaccagac ccgcaacttc 2565541 gtatctgcgc acttgctcgt ccagtgcgta aagcagctgc tgtcccgtcg tcgcaccagc 2565601 ataagcagtt ctgtggtgct gtgtaccccc gaatcggcgg aaatcaagca ggccttcagg 2565661 cgtccggtta aacatgacgc ccatccggtc taataagtgg atgatcgaag gcgccgcttc 2565721 acacatcgcc ttgaccggcg gctggttggc aagaaagtct cccccgtata ccgtgtcatc 2565781 aaaatgttcc cacggagagt caccttcccc ttttgtattg accgctccgt ttatgccgcc 2565841 ttgcgcacaa actgaatgag aacgtttgac aggaacgatg gaaaacaatt taaccgccat 2565901 tcctgattcc gctgctttaa ttgtcgccat gaggccggca agacccccgc cgactacgat 2565961 aatgcttgat tgactcatga tagcccctct ccctctagta atctagtact cttaaacaaa 2566021 tgcaaaaatc gcttttaagc ctacgtatga cagtgcaaca aaaataatca gcgtaacgta 2566081 tgtcgaaatt ctttgagaac gaggcgttac cgtgatgccc catgtaacag cgaaagacca 2566141 taaaccgttc gagaagtgga aaattgttga taaaacaccg acaatgtaaa aaccaagcat 2566201 agccggagag ctcaaaatat tcgccatcat gtcgaaattg acctcagcac ccatttgtgc 2566261 ggcaatgcgg gtttcccaca cgtgccagct gacgaaaatg agggtgatga taccggttac 2566321 acgctgcagg acgaatagcc agtttctcat gtagctgtat tgaccggcgt tatttttcgc 2566381 agtaaacgct atgtacacac cataaactgc atgataaatt aatggtaaga agataataaa 2566441 aatttccaag gcatacctga aaggcaggct atccataaaa tgagcagcgc tattgaatgc 2566501 ttcagcgccc cttgcggcaa actggttgac gactaaatgc tgaataagaa agatgccgac 2566561 cggtatgacg ccaagcaagg aatgcaatct tcgaaaataa aactctctgt tcccagacat 2566621 tactttaccc cctgtttgat aagtgcgaaa tgtgctaaat ctcttccccc acttctttca 2566681 attgtaagca ctttattaag atttattgac aatttcattt tactcctccc tcaaaagggc 2566741 gtcaagaaaa cgcgtacata aattataatt ttccgaattg attagttgat tgaaaaattt 2566801 tattttatca atatatattt cttgcttaat ttttcataag aattacagga tcattctgta 2566861 atcctccccc ctgtttgagc tataatatac gcaggagaga ggggagacag atatgaagtc 2566921 taaatttgaa gcatctattg acaacctaaa agaaattgaa atgaacgctt atgcctacga 2566981 actaatacga gagatcgttc tcccagatat gcttggccaa gattactctt ccatgatgta 2567041 ttgggcagga aaacatctcg cccgtaagtt tcctcttgaa tcatgggagg aatttccggc 2567101 cttctttgaa gaagcgggct ggggaaccct caccaacgta agcgctaaaa aacaggagct 2567161 tgaatttgaa cttgaagggc cgatcatttc caaccggctt aagcatcaga aagaaccttg 2567221 ctttcagctg gaggctggtt ttatcgctga acaaattcaa ttgatgaatg atcagattgc 2567281 cgaatcatat gaacaagtga aaaagagagc cgataaagtg gttctgactg tgaaatggga 2567341 tatgaaagac ccagtgtaat caaaaaggcg gtgactgcat agtcccgcct ttttgattgt 2567401 cattacacag ctgaagggtg ttttgaaagc tcaaatgcat cgtgaagcga ctcgactgct 2567461 ttcaccatgt cattttcgct tacgactgtt gacactttga tttcagatgt gctgaccatt 2567521 ttgattaaaa tgtttttttg cgccagtaca gcaaacattt cagccgctac accgggattt 2567581 gagaccatgc cggatccaac aatagatact ttagccaatt tgctttctgt ctcgattttc 2567641 tcaaattcca gcgcgtcttt atactcttca agcaccgcaa cggtttggtc tgcatcttct 2567701 gttttgacag agaaggaaat tccagtcttg tcctcggcct gcgtttggat aatgatatcc 2567761 acgtttatgt ttcttttggc aagtgttgta aaaatagtag acaaagttgt caggccgcta 2567821 gtcagcccgt aaatggttac tcttgtgatt tgatcttcaa atgcaatgcc tctgacaatt 2567881 aaattctgtt ccatggatga ttcctcctca attaatgttc ccgcttcggt ttctgtactt 2567941 gaacgcactt ctaacggcac ttggtaattt ttcgcgaact caactgctct cggatgaaga 2568001 acaccggcgc ctaaattggc aagctcaagc atttcatcgt atgagatgcc ctcaagtttt 2568061 ctcgctgatt tcacatagcg cggatcggtt gtaaacacgc ctggcacgtc tgtgtatatg 2568121 tcacatttat cagcttttaa agcggcagcc aaagcaactg ctgttgtatc tgaaccgccc 2568181 cggcccaatg tcgtaatttc acaatcctct gtcatgcctt ggaatcctgc aacaatgaca 2568241 atttttcctt tttcaagctg gtctgctaaa accgaagtgt cgatatctgt aattctggcg 2568301 tttccgtgaa tggcctccgt acggattccc gcctgccagc cagtataaga cacagcgtca 2568361 tagccttttt cctgcaatgc cattgaaagg agtgaaatcg tgacctgctc gcctgtcgcc 2568421 agcagcatat ccatttcgcg tttgctcggc tggtcagaaa tagcttttgc aaggctgacc 2568481 aattcgtcag tggattttcc cattgctgaa acgacgacaa cgacttgatg gcctttctgt 2568541 ttttctgcaa ttgcgcggtt tgccgcattt tgaatttttt cgactgagcc gacggaagtg 2568601 cctccgaatt tttgtacaat aagacccatg tattaccacc ctttacattt tggttcgtgc 2568661 gggtgaggag aaagagcgct ttgtccacaa taaaaaaagc aatgagagga atactctcat 2568721 tgcttatcaa ttaatcatca taaatgatta tgaacaacga gatagccctc caagaaaatg 2568781 atttcttgac agccttacat ttattcaatg cacggccagc aaataatacc gatggggttt 2568841 tatttgcttc ggcgacgctc ccctttcagc ctttttcaca gaatccatct ttctccaaag 2568901 gcatactctt gaagttcgca cctctatctt caccatataa cacgatctaa ctatgaaatt 2568961 agttcacatt ttatcagatc ttatttaaaa ggacaacatt atttttgcaa tttgtcgtaa 2569021 aggagctgag ccgccgctgc gggaacaccg gcttttttga tgtcctcaag gcttgcttcc 2569081 ttcatttttt taacggaacc gaaatgcttt aacagcattt tctttctttt ctctccgata 2569141 cccgggatgt cgtccaaaac ggattgaaac gcgctttttc cccggatttg cctgtgaaaa 2569201 ctgattgcaa aacggtgcac ctcgtcctga atgcgctgca ggaggtaaaa ttcctggctg 2569261 tttcgttcca gatacgccac ctccagcgga tcaccgatca gtaaatttga ggttctgtgt 2569321 ttttcatctt tcgctaaacc ggcgatcggg atatccaagc cgagttcatt ttcaatgaca 2569381 tcccttgctg cgttgatctg cccttttcct ccgtcaatga taatcagatc gggcagcggc 2569441 agattctcac gaagcactct cgtatagcgt cttctgacaa cctctctcat agaaccgtaa 2569501 tcatccggcc ctgtaacagt tttgatttta tatttgcggt attccttttt gtatggtttg 2569561 ccatcgataa acacaatcat cgcggaaacc gggtttgtcc cctgtatatt tgagttatca 2569621 aacgcttcaa ttctgtgcgg cgtataaata tttaatgcct cacctagttt ctgcactgcc 2569681 ccgattgaac gctcctcgtc ccgttcgatt aaagagaatt tttctttcaa tgcgattttc 2569741 gcatttttat gggcaagcat gagcagttct tttttcgggc cttttttcgg ctggtgaacg 2569801 tttgtttcca gtagctgctc gatcatagat tgatctatgc tgtccggaac taaaatctcc 2569861 ttcggaagga agtggttgtt ttttgaatag aactgcccga tgaacgtgag gaactcttca 2569921 tctgcttcct gataaagcgg gaacatgctg acatcgcgtt caatgagctt tccttggcgg 2569981 atgaaaaaga cctgcacgca catccagccc ttatcgtacg cgtacgcgaa cacatcacgg 2570041 tcgactagat cgttcatcgt cattttttgt ttttccatcg ttgattcaat atgggcaatt 2570101 tggtcacgaa gctcttttgc tcgttcaaac tcaagattct cagcagcttc atgcattttc 2570161 tcttcaagct cttttttgac ctcattatag ccgcccctta agaaacgtgt aatgctttca 2570221 accagctctc tgttcgtctc ttcggaaata tcctttacac acggagcaag gcattggccc 2570281 agatgatagt aaaggcacac tctgtccggg agcttggagc attttctgag aggatacaga 2570341 cggtcgagca gtttttttgt ttcccttgct gcctgtacat tcggatacgg cccgaaatag 2570401 cgccctttgt cttttttgac attgcgggtg acaatcagcc ttgggtggcg ttcatgggtg 2570461 agttttatga aaggataggt tttgtcgtct ttgagcatga cgttgtattt cggatcatgc 2570521 tttttgatca gattcatttc taaaataagc gcttcaagat tggaggacgt cacaatatat 2570581 tcaaaatcct cgatttccgt cacaagcctt tgggttttcg cgtcgtgaga accggtgaag 2570641 taggagcgca ctctgttttt cagcactttt gctttcccta cgtagatcac agtctgctgc 2570701 cggtccttca tgagataaca acccggttga tcaggaagga gggcgagttt ttctttcagt 2570761 tgtttgttca tatgttaccc ttccttatgt ttaatccttt atttccagtt taacacgaac 2570821 gtttgttttt ctctatggtt cacaattggc gaataaaaaa agcgatccct caatcggaat 2570881 cgctctggca tgtaagcagc ggaaaattaa agatgtttgt ttacaagctc ttgaagcgct 2570941 tcttttggtt tgaagccgac tgaagtttca actacttcgc cgtcttttaa cacaagaaga 2571001 gtcgggatgc tcataacgcc gtattttccg gcagtttctt ggttttcgtc tacatcgatt 2571061 tttacgattt tcagtttgtc tcccatttct tgatccaatt cttcaagaac aggtgcaatc 2571121 attttacaag gtccgcacca aggagcccag aagtctgcca gtacgacgcc ttcgcttgtt 2571181 tcagctgaga aagattgatc agttgctttt acgatagcca ttattgaatt cctccaatgt 2571241 gaaatgatga tttttagtat agcatctccc attcgttcac gctattttaa tgcttacaaa 2571301 ttattttttc ctgatcacag ccggtttact catttttata tggttgaatg ggatatgctc 2571361 tttttttaaa acacaaatct gataatggcc ccgatcacta caattgcccc aataatcatt 2571421 aaaatggtac gaagcataag atcacatctc ctcttcactg tcatgtactt taccatgccc 2571481 tgccggagct gttttaaaac ctgaaaaaga gcgccggcat gaagctccgg cgctcttgcg 2571541 cgattaagaa tcagcacgca gcgtaagtaa gacgactgac attggcggga gttttacttt 2571601 cagtttgttt ttgctgagcg tgtattgtct gaaggattcc ggtttgacat gatgaggatc 2571661 gtcaaacgtg ttatgcgcat tcattttttc tgccgtaaga atgactccgg aatggtccgc 2571721 tgccttgtgt aggcccctca gctcgatttc cgcctctgct ttgttttggt gatcgatgtt 2571781 gcaaattgtg atattgatat cgccttcagc ttgtttcgac gctgaaatgc tgatttgcgg 2571841 aagcgtttca ccgttccatt catagtcggc agacattgtc tctgtggcta aaagagaagc 2571901 gtcctggtgc accttaaaca tattgaatac atggtacgtc ggtgtcaaaa gcatccgctc 2571961 tccctcagtc aaaatcatcg cttgaagaac atttactgtt tgggcgatgt tggccatttg 2572021 cacccggcgg caatgctgat ggaaaatgtg gaaatgagaa gccgccacca gtgcatcacg 2572081 aatggtgttt tgctgatata agaaaccggg attcgtgcct ggctcgggat caaaccacgt 2572141 gccccattca tcaataatca gcccgacccg ctgctccgga tcgtaccggt ccataatcgt 2572201 gccgtgtttt tgaatcaatt catcgatgta tttggctttt ttcatcgtaa taaaccattc 2572261 atcttccgtg aattctgtgg ctgatccttt gcccttccag aaatcccccg gaatcgtgta 2572321 ataatgaaga ctcaacccgt ccatcaggcc agcggctttt ttcataagca cgtccgtcca 2572381 attaaaatca tccacatttg cgccgcctgc aattttataa atgtcattcc cgctgtaatt 2572441 gcggacataa gtctgaaaac gccggtacag atctgcgtag tattcgggat gcatgttgcc 2572501 gccgcagccc cagttttcat tgcccacgcc gaaatatttc agcttccaag gctcttctct 2572561 tccattttgc tttctccagt ctgacatcgg cgtgccttct tcaaatgtca tatactcaat 2572621 ccactccgac atttcctgaa cggttccgct tccgacattg ccgcaaatat atggctcgca 2572681 ttcaagcagc tcgcaaagca tcataaattc atgcgttccg aattcatttg attcaattgt 2572741 accgccccag tgagtgttca gcattgtctt acggtcaccg acaccgtttg cccaatggta 2572801 ttcgtccgca aaacacccgc ccggccacct aaggacagga atgtgcagct gtttgagcgc 2572861 ctccagcacg tcctttcgta tcccgttgat attggggatg tctgagtccg ttccgaccca 2572921 gatcccctca taaatccctc ttcctaaatg ctcagcaaaa tgaccgtata tatttttgtt 2572981 aatggttcct tttgcgatat ctgtttgaat cactgcttga tgttcagaca tgcctctgat 2573041 cattcctttc atacggatat gaaaagcacc acagtcaaat atgtgatctg tcgtttgcct 2573101 gaggagtcag catgaatgta agcgctttta aagtaaccat attatatatg ttcgtacatg 2573161 tcaacgacat tttctattgt ttttatattt gtacgtatgt atttataaat atgaaaaaac 2573221 ccggactttt aaagtccggg atttccttta tgagtgtata ttcagctgtt tgaattcctc 2573281 agttaataac gggacaactt caaataaatc accgacgatg ccgtaatccg ctattttaaa 2573341 gatatcggct tcggggtctt tattgatggc gacgatcacc ttgctgtttg acatgccggc 2573401 caaatgctgg atggcgccgg aaatgccgca tgcaatgtac aaatccggag taacgacttt 2573461 cccggtctgc ccgatttgga gagcataatc gcaataatca gcgtcacatg ccccgcgaga 2573521 agccccgact gcggccccta gcacctctgc aagctcctgc agcggctgaa atccttcctt 2573581 gcttttgact cctcggccgc ccgcaacgat aattttcgct tcggagagat caacaccgtc 2573641 cgccgttttt ttcacgacct cttggataac agtgcggagg tcagtaagag aaacatcaat 2573701 gctttcgatg ctccccgatc tgctggtgtc tttttctgaa gcttgaatgt tattggggcg 2573761 aattgttgca aagatcatcg gatcggttga aatgacgcgt tcaaaagctt tccccgagta 2573821 aatcggccgt gtgaacacaa cattccctcc ggtaacgctt acatctatag catcagaaat 2573881 taagcctgtt tgcagacggg cagcaagctt cggtgaaaga tccttgccca ttgccgtatg 2573941 cccgaagatg actgaatcag gattttcttg ctcgataaca cctctcatga cctggctgta 2574001 cccgtctgcc gtgtatgttt tcagcttcgg gtcctcagcg gtaagaactt tatctgctcc 2574061 gtaatgaata agctcttgtg caatgctttg tacattttca ccgatgagaa caccgatgac 2574121 ttccccatct cctgaaatgg ttcttcctgc agctattgct tcaaaggtga catttcgcaa 2574181 ttccccatcg cgtatttctc caagcacgat cacttttttt cccattctaa catccccctg 2574241 tttctttgaa tgtccaagtt ttaaatgact ttagcttcgc tgcggagcaa tgaaacaagc 2574301 tcttttgcct gttcagcagg ctcaccttgg agaagcttcc cggcttcttt tttcggcggc 2574361 agaaaacgtt caatggtttt cagctttggt tcagcatcct cttcgtccag atcaagatca 2574421 tcaagttcaa gctcttcaag cggctttttc ttagccttca taattcccgg aagcgatgga 2574481 tagcgcggct cgtttaagcc ctgctgagct gtgacaagca atgggagcgt cgttttgatt 2574541 ttttcaacat ccccttcgac gtccctttct gcttctgcat cagtgccgtt gatttcgagt 2574601 ttggtgatcg tagtgataca cggaatgtcc agtagctcgg caagccgagg cgccacttgt 2574661 cctgatcctc cgtcaatggc aacatttccg ccgagaatca aatcaaactc ctgatccttc 2574721 atatagtggt ataaaacttg agaaatggaa tattggtcgg gttcatcaag atcatcttct 2574781 atgttgatta aaacagcttg gtcacaaccc atggcaagcg ccgtacgcaa ttctttctcc 2574841 gcttcttcac cgccgaccgt gacagcggtg atcgtgccgc catgcttttc cttcagctgg 2574901 atggcttctt ctatcgcgta ctcatcatat ggattaatga tccattccgc tccgtcatcc 2574961 tgaatctttc ctgtttcaat gacgattttt tcttctgtgt caaacgtccg tttcatcagt 2575021 acaaatagat tcatgatcat atcccctttt attcgccttt gaactgaggc tttctttttt 2575081 cgagaaatgc ctggatgcct tccttggcgt cctctgactc aaatgcttcc ccaaatcgct 2575141 ttgcttcaag ctttaagctg ccttcatagg aatacacctt gttggaataa agaagttcaa 2575201 gcaaagatgc cagcgtttgc gggcttttct ctgcaaactt agcggcaagt gcttttgctt 2575261 tttcaatcac ttctgcctca tctttcgctc caattgagac aagtccgaga tcaagcgctt 2575321 cttttccgga tatcggttct cctgatccga tgagctccag tgctttggct gtaccgacat 2575381 atctcggaag gcgctgtgtc cccgcaaaac ctggaatgat accgagatta agctccggga 2575441 gccccagctt agcatcttct gccgcgattc tgatgtgaca ggccattgca agctccagcc 2575501 cgcctccgag agcagcgccg tgaatcgctg cgataatcgg ttttggaaaa ctttcgattc 2575561 tctccattaa ctgctggccg cgctcagcga gcaatgagga atcctcattg cctttaagcg 2575621 atgtaaattc tttaatatca gcgccggctg agaaaaatct tccctcgccg tgaatgataa 2575681 tgcttcgtac gcctgcatct gtctcacatt gatcaagaca ggaagacagc tcttctaata 2575741 tccggcttga aagcgcgttt gccggcggat tgtgaatcgt caagactgcc acaaattgat 2575801 caaccgcaag tgaaattgca ttcataggac agaactcctt tacttattgt gaattccgga 2575861 taccaataat tctaaaacgc tgtttgaaag cgcaacgaga tcgtactttt ggtcattcat 2575921 cacccaagtt gtcacagttt cgtcaatcgt tccaaaaatc atctgccggg cgaggcggac 2575981 atcgaggcct tcttttattt cgcctgattg tataccttcc gtcaaaatgc catccaaaat 2576041 atttaagtag ccttttaata tttcgttgat tttttggcgc agctccaagt tggattggcg 2576101 gagctcaagc tgcgtgacaa tggcgagatt atggtcaccc gctaaaaggg aaaaatgctt 2576161 tgaaatcaca agcgccaatt tctctttcgc tgttgctttt tctttaatgt cctcttccat 2576221 ccgctcaata aattgaccca ttttttcttt gaaaagagaa attaaaatat cttctttgtt 2576281 tttaaaatag agatagatgg tgccgtccgc taccccggct tgtttggcaa ttttggatac 2576341 ctgtgactgg tggtagccgt tttctgcaat gacttctact gctgcatcaa taatctgcat 2576401 atactttggc cgtttttgct tcaatgttca tcgttccttc ctatagaaat gaatgactat 2576461 tcattcataa tttcatgata agaaggattt tcaggtttgt caagtttatt cataggcgtt 2576521 ctcttttttt atttgatatg atgattttcg gtttcttctt caagtaaacg ccttcttaaa 2576581 atttttccca ccgccgtttt cggcagctcc tttctgaact cataggcttt gggcacctta 2576641 tagggagcta gacgtgatct cgcaaaagcg tccagttctt ctgtatcggc ttttgcgcct 2576701 ttctttaata cgacaaatgc ttttactgtt tctcccctgt aggaatcggg aacgcctgcg 2576761 acaacaattt cctggatggc ttcatgttca taaagcgctt cttctacctc acgcgggtaa 2576821 atattgtaac cgccggcaat gatgatatcc ttcttcctgt cagcaatata gaaaaagcct 2576881 tcttcatcca tatagcccat gtccccggtg aacagccagc catctctcag cactgcggcg 2576941 gtttcctctg gtttattcca gtatcctttc atgacttgcg gaccttttac aatgatttct 2577001 ccatgctcat acggagcggc aagctcaccc gtctcttcag aatagatcgc agcgtccgta 2577061 ctcggccaag gacagccgat actgcccggc ttgttttttc cccagataaa gttggcgtgc 2577121 gtcactgggg atgcctcaga caaaccatag ccttccacaa gctttccacc agtcaccttt 2577181 tcaaatttct gctttacctc cacggggagc gcggctgatc cgctaagaca gcttttaatg 2577241 gatgacagat cataatgctg caattcaggg tgatgcaaaa ggccaatgta aattgtcggt 2577301 gcgccaggaa agagcgtcgg tttgtgtttg tcgatgattt taagtgtttc gagcggatca 2577361 aacttaggaa gaagaatcat ttcgaagcct agtttaatcg aatagttcat gactgccgtc 2577421 agtccgtaga catgaaaaaa tggaacgatg cccagcactt tttcagcgcc ttctttcacg 2577481 tcatacatcc aagcggcgca catttcagta tttgccaaaa tattttggtg cgtgagcatg 2577541 accccttttg gagctccggt tgttcctccg gtatactgga ggacagcgat atcatgctca 2577601 ggatcgatct tcgggattgt caggagttca gttttttcct gcttcataca ggaagcgaac 2577661 gtgtgaatgt tagctgtttt gtcaaagtcg atatgcactt tttgtttttg cgtcagcggg 2577721 taaagaatat ttttcggaaa aggcaaatag tcttttacac tggttatcaa aatctggtcg 2577781 actattgata acgttttcat ttttattgcc ttcgggaaaa gcaaatctaa ggtgatgatt 2577841 acacttacct gagcatctct aagctggtat tcaagctcat gctcggtata aagcggattc 2577901 gtctgcacca cgatgccacc ggcaaacaag acgccataat aagaaatcac tgtttgcggg 2577961 caattgggca gcataacagc cactctgtct cctttttgca ggccattgca ctgcaaaaaa 2578021 gctgcaagtt taagagcatc cgtcagaatg tcatgaaagg tgagtttttt tccataaaac 2578081 gatattgcgg ttttatcagg gaatcgtgcg gcggagtctg tcaggatgga ttgcagggtt 2578141 ttattcggca acggaagctc atgcgggata tcgttgggat actcggcaag ccacggcttt 2578201 tgagactgca taaaacctcc cctttcgatt ttagagatcc accttatcat tatagcagat 2578261 ggacggcaaa aaaaagaaaa agaaaggtaa atctttcttt ttctcataat atgaacagat 2578321 atataagacc aattaacaaa aagattcccg ctgcggcgag cagtattttc gcaagctttt 2578381 ccatctattc tccgtcccct tatattccgg ctgccaccac aaaagaaagc ccgacagaaa 2578441 tgacaaatga aataaagccg acagcccggt tatcattttc gatttcctga tcaattttaa 2578501 accgcggagt caaaaactca aaaataaagt agctgatcag aagcataaca aacccgtaaa 2578561 cgccccagcc gatcatttgc agcagcgaat tatgctggga gatggaatgc tgaaatacgt 2578621 ttgcgattcc caaaattttt ccgccggtcg ccattgccac cgcaagattt cctttttgaa 2578681 tctcttccca gtttttataa gccgtcacca gctcaaacac agtcaaaaag aggacgaggc 2578741 agagaaccgc gacactgtaa tatgccgcga tttccacaag ctcgttttcc caaaaatcac 2578801 tcatggccat actccctttt attttagttc aacaaccgta acgcctgatc ctccctcacc 2578861 tgcttcaccg aaacgggaac ttttgacgct gcggtggttt ttcagaagat cctgtacgcc 2578921 ttttcttaaa gcgccggttc cttttccgtg gatgattgac actcttggat atccggctaa 2578981 caccgcatca tccaagtatt tttcaacccg gctgagggca ttttcatagc gttcgccgcg 2579041 aagatcaagt tcaagcgata cgtgatagtc ctttcctttg accgctgtaa tcattttttc 2579101 tttttttggc tccggagctg atttgataaa ctccagatct ttttctttta ctttcatctt 2579161 taaaataccg atttgaacgt tccattcatt gccgcctgtt ttttcgagca atgttccttt 2579221 ttgcccgaaa gtgaggactt tcacctcgtc gccaggctta aagtcgcgtt tttgcgtttt 2579281 cggcttttcc ggtttcttgg acttttcaaa agcaggcata gcgccttcta accgtttctt 2579341 cgcgttaatc agctcgtgat ccttgaagga tttgtgttct tcttttatgg tgcgcaattc 2579401 atgaataatg tcctcggctt ctttcattgc cgcttttact ttttcagcag cctgctgttc 2579461 tgcctcttca agcattttgt cttttttgct gttaagctcg atgatttgct gctgcagctc 2579521 tttatgcagt ttttccgctt cttttctgat tgattctgtc tcagaaagct cttcttccgc 2579581 acgttttttg ctttgttcca gcgacgcaat catcgtatcg acttcgttat gctcggccgt 2579641 catttctgac ttcgcctgcc cgatgatatg gtccgggagc ccgaggcgtt ttgaaatttc 2579701 gaaagcattg cttcgacccg gcacaccaat taaaagttta taggtcggtg acagcgtttc 2579761 gatgtcaaat tcaacgctgg cattcatgac gccttctctg ttatagccgt acgccttcaa 2579821 ttccggataa tgcgtcgtag ctaacactcg tgcattggtg cgatgcacgt catccaagat 2579881 gctcatggcg agggccgccc cctcctgcgg atctgtccct gcaccaagtt catcgaaaag 2579941 cacaaggctg ttttcattga cctgttctaa aatgccgaca atattcacca tatgggatga 2580001 gaacgtactt aaactttgct caatcgactg ttcatcaccg atatcagcga atacgtgctc 2580061 aaatactgcc gcttctgacc cttcatctgc cgggatatga agacctgact gcgccattaa 2580121 ggttagcagg cctaacgttt taagggtgac tgttttcccc ccggtgtttg gccctgtgat 2580181 gacaatggtt gaaaaatcgc ggccaagctc gatgtcattg gcaacaacct gatcaggcgg 2580241 aagcaatgga tggcgggctt ttttcaaacg gataaagccg gtgtcgttca taatcggttt 2580301 tgtcgcttta accgcttttg catatctagc ttttgcaaaa ataaagtcaa gcgtctgcag 2580361 cacttgcaaa tctagaaata gctcctctgt atactctgcc gttttctctg tcagcacacg 2580421 caaaatccgt tcaatttctt gcttttcttt cactttcgcc tgctgaaggg aattgttcat 2580481 atctacaatc gcctgcggtt caatgaatag tgtcgcacca gaggatgagg tgtcgtgcac 2580541 aattcctcca tagctggatc tgtactcctg tttgaccggg atcacaaagc ggtcattccg 2580601 aatcgtaaca atcgtatcag acagcatttt cgatgcggaa gaggaacgca gcatcgactc 2580661 taaccggtct ctgactcttg attcgagtgt tctgagctgt gtgcggattc ctcttaatgt 2580721 ttccgatgca tgatcaagca cttctccgtg atcatcaatg caggaattaa tgtcccgctc 2580781 taaatcggac agcgtgataa gctgttcagc atgctgatgg atcagcggaa tgtcgacacc 2580841 gtcttcagcc atttgcgtga taaaatgttt catttgttta actgcataaa gcaggcctga 2580901 gatttcagtg aattcagaag gactgagaac gctgccgatt tccgcccgtc ttaacgctcc 2580961 tctgatatct acaaggccgc caaatggcgc ttggcctctc agccggataa tgtcagaagc 2581021 ttcgtctact tcatccagct gttttttgat ttcgtctata gaagcagaag gcttaagctc 2581081 gagaagcatt tcttttccga gcgatgaagc ggcatgccca ataacctgtt ctttcacttt 2581141 atgaaattca agagctgata atactttttg ctgcacgatt gtgtgagcct ccttacttaa 2581201 tcgttgcgct tcagaaatgc ctctacgtct ttaagcgacc gggcattcag aacgtttttc 2581261 gtttccgtcc atcctttgcg cgcggcagta acgccagttt tcatatcgtc taacatctca 2581321 atattatggg catcagtatt aatcaccaat gtaacccctt gttcgtttgc tttcattaaa 2581381 tgctctgtgc gcagatcaag gcgcgcaggg ttggcattga gttcaagcgc cgtatttgtt 2581441 ttcctcgcaa gctcaatcag ctgatcaata tcgatttcgt aaccggcccg tctgccgata 2581501 aggcgcccgg tcgggtgtgc gataatgtca acatgcttgt ttgtcagtgc cgtctcaagc 2581561 cgtttcataa tcacgtgttc cggctgatta aaactggaat gaatcgatgc aataacgata 2581621 tccatttccg caagcacatc gtcatcataa tcgagcgtac cgtcaggcag gatatccatc 2581681 tcaacgcctt tcaaaatacg gaagttttca aactctgcat tcagcgcgtc aatttctttt 2581741 gcctgctgct taagtctttc tgcagtaagc ccgttggcga cctttaaata ttgtgagtga 2581801 tcggtgatcg ccatgtattg atagcctttt ttgatgcagg cttcagccat ctctctgatc 2581861 gaaaatgcgc catcgctcca cgttgagtgc atgtggagat cacctttgat ttgcccgagc 2581921 tctatcagtt caatgctgtc gctgtaggtt tccacttcct gtccgctttc acgaatttcc 2581981 ggcggaatca gcggcaggcc gaagtgcgca taaaattcac gttcactcgg aaatgttttg 2582041 atctctccgg tttcaactgt ctcaacgccg tattcactga tccgctcgcc gcgttctttg 2582101 gcgatttggc gcatcttaat attgtgatcc tttgatcccg taaaatgatg gagtgttgtc 2582161 ggaaactgct cttccgtcac aagacggaaa tcgacgcttg tttcatattc aaaggaaagg 2582221 atgacggaca ccttcgtatc tccgcttgcg atcacgcttt tgatgtttgg cagctcaaga 2582281 agctgctctc ttacttcagc cggatgatct gtagcaatga tataatccag atccttcacc 2582341 gtttcccgcg ctctgcggag acttccggca cgagaaaatt tgatgatatg cgtaaattga 2582401 gaaagatgct cctcaatttc ccgcgcgatc cggagggcgt agccgatcgg gaaccgttca 2582461 ggctgttttc cggcttcccc gagcgcctgt aatatttttt cttccgattt tttgccgaag 2582521 cccgcaagac cctggacctt ttgctgctca caggcttcct tcagagattc tgcatcgtgt 2582581 acgccgagct ctttatacag ctttgcgatt tttttgccgc cgagccccgg cagcttcaat 2582641 aaaggcacga gtccttccgg cacttctttc tgaagcgatt cgagcgtgct tgactttcct 2582701 tcatctatat actctttaat gacgctgtac gttccttttc caatgccgga cagcgacatc 2582761 atatcgtcca tttctgataa gcttcggtcg tcctgttcca gagctgccgc cgcttttcgg 2582821 aaggcggata ctttaaacgg gttgtcccct ttgagttcca tatagactgc aatggtttca 2582881 agcagccgga taatatcttt tttatgcata tcataacccc cagacgttca catatgtttc 2582941 catcatactt gaaaaaaact tctccggaca agagaagttt ttttatgccc cgtactgtgt 2583001 ccacagctct tgtaaaagcc ctgacaagta cggtgtatgg ttaatgatca catttgcgag 2583061 agacgattgc cccatcattt gctgcaacgc gtctaccggc agaacggatg cgacatacag 2583121 cagcacaaat gtaaataaat agacttctag aaaaccgaga acggctccca gcatctggtt 2583181 gatttgttta atcaccggaa tgccggctac aatactcagg aacgagccga tgattctcag 2583241 taagatttta gcaatgataa ataaaacgat aaacgcaatc gcattatagt acgctgcttc 2583301 caaattcccc gtaaaaaaag aaagagccgg ctgtcccgct gaaaaatcgg gtgcgggaat 2583361 ccaatgtaaa tgcggtgcca cgtttttata gaataaagcc gcaaaggcaa ttgataaaat 2583421 aaagctcgtc aagcggataa actgcaggat aaaaccgcgt tttaacccca gtaaagtccc 2583481 catcaggagc aagattaaga tgatgatatc tagcatagtt gttcaatcct tttctttaag 2583541 ctgacgctcc agtttttcac atttctcttg taatttgaca taatcgtgca ccacatttac 2583601 cgctgtcagc actgcaagtt tatttatatc aaggtatgga tttttttcat tgatttctct 2583661 cattttatca tcaacaattc cggcgacata cctcatatgg gctctgcttt cttcaccgac 2583721 aatcgtgaag tgctggccgt aaatgtcaac ggttgttttt gtttttttgc cgtcagacaa 2583781 cgtttctcct ccattccgcg agaatcctag ttcttatcat aacacgttta ttaaatgaat 2583841 ggaaagacga gcctcccgct gttatgatac actggtatat acagcgaaaa gtgtaaaaaa 2583901 aggagattat tacgtgtccc attcagtgat aaaagtatcg ttgtctgcta ttgaccaaat 2583961 gaaaatgacg tacagcggtt cacttacagc ctctgttccg cagggagccg tttttcaggc 2584021 aaaaccgccc ggctgtacca ttacagcata tcaatcaggt aaggtcttgt ttcaaggaaa 2584081 aaacgctgcg gcagaatccg cgcgctgggg aacagcagag cctcaggaaa agaagaaaac 2584141 ggccaaaaag ccggctgatc cccgctatgc ccctccggca gatatcgccg gaatgtctgt 2584201 tatcggttct gacgaagtcg gaaccggaga ttactttggc ccaatgacgg ttgtatgcgc 2584261 gtacgtcgac aaaaccatgc ttcctttaat gaaggaactc ggtgttaagg attctaaaga 2584321 tttaaaagat ccgcaaatca tcgagattgc ccgaaacctg attaaaacca ttccgtacag 2584381 cctgctggtg ttaaagaatg aaaagtataa cagcatgcag gaaaaaggca tgagccaagg 2584441 gaaaatgaaa gctttgctgc acaatcaggc gatcacacat ttattaagaa aattggatgg 2584501 agtaaagcct gaagccattt tgattgacca attcgctgag ccaggcgtct acttcaatca 2584561 tttaaagggc agagacattg tgaaggagcg gacctatttt agcacaaaag ctgaaggtat 2584621 tcacctggct gtcgccgctg cttcaatcat tgcaagatat tcatttttaa tggaaatgga 2584681 taaactatca cgcgcggcag gaatgacgct tccaaaaggg gccggtccgc acgtcgatga 2584741 agcggccgcc aagctgatcc tcaaaaaagg ggcatctgca ctcagaacct ttacaaaact 2584801 ccatttcgcc aatacgcaaa aagcgcagcg ccttgctgat aaaaaacgtt catagaaaaa 2584861 agcttgcaga tttctctgca agctttttta tcagcctctt aaaacagctt gatatgtgtc 2584921 ttctaacgct ttcagcactt tgctgtgcgc ctttgtcact tcttcttcag tcagtgtttg 2584981 ttcaggattg acatactgga gtgagaaagc gactgacttc ttgccttcct ccatatgctc 2585041 tccttcgtat acgtcaaata cggttacctc tttcagaagc ttgcccccgg cctctttaat 2585101 gacgctctcg agctgtccgc ttgtgacggt tttatctgtt acaagagcga tatcacgtgt 2585161 cacagacgga tattttggaa tcgccgtgta aacaagcggt gctgtttctg ctgcgagcaa 2585221 cgcatgaaga tcgagctcaa atacgtatgt ttcctttata tccagttctt tttccaatga 2585281 aggatggact tggccgatga agccgatcag agaaccattc aataaaatgt tcgctgttct 2585341 gcccggatgc agctgtttgc gttcagactg tacaaattca atgctgtcta ggacgttgag 2585401 tttgtctaac agcccttcca caattccttt gacaacaaag aaatcaactg gtttcttttc 2585461 accctgccat agctgcttgc gccataatcc ggtaacagct cctgctacgc gttctgtttc 2585521 aacaggtttt gtgtcctctt ccttcgttag gaaaacggag ccaacttcgt acagtgcaac 2585581 tgagtcagtc tgcctcgcaa gattgtaaga aacagaatca agcagatttg gaacaagact 2585641 gtgtctgaga atgcttcttt cttcactcat tggaagcgca agcacagtat tcagtgattt 2585701 ttcaatcgca aacgctgtcg ctttcttctc gtttgtcagt gagtaagtga tggcttgtga 2585761 taagcctgcg ccttcaagga agcgtctgac tttacggcgt tttgcctgat atggcgttaa 2585821 tccgcctgta gttcccgctg tctcaggaag cgtagacgga atgttatcgt agccgtacag 2585881 tcttgccgct tcttcgatta aatcctcttc tattgtaatg tcaccgcgcc gtgatgggac 2585941 agtcacaacg agaagatcat ccgcttcacc gaccgtaaaa ccgagacgtt tataaatgct 2586001 gatcagttct tctttactga tcgtcaggcc tagaacgctg ctcactttgt cagcagatac 2586061 gtgaatgtta tttgcttcga ttgtcaggtg atcttcctca accgttccag caagcacctc 2586121 accgccggca tacagatgga tcagctgcgc agcccgttct gctgcaagac gtacgcgtgc 2586181 cggatcaatt cctttttcaa atcttacgct tgattcactt ctcaaaccaa ggtctttgga 2586241 agccttgcga accttctgcc cgttgaaata cgcagcctca agcaaaatgg ttttcgtatc 2586301 ttcctgaacc tctgactctg ctcctcccat gacaccggca acggcctgcg ctttcgttcc 2586361 gtttgtaatg acaaggtgat cggcagacag cttacgttct tgatcatcaa gtgttacgat 2586421 catttcattc tcagctgctt ttcttactac gacttcctta gagccaaatc tgtcataatc 2586481 aaacgcatga agcggctgtc cgtattccaa caggacaaaa tttgtgatgt caacgacgtt 2586541 gttgtgcgga cgaatgcctg cattcatcag ctttgtctgc atccaaagcg gtgacggagc 2586601 aatcgtgaca tttttaatga tttttgcagt gtacagcggg ttcgcttctt gatcttcaat 2586661 tttgactgaa atgtaatcag acgcttgttc tgaagcagcc gggtaatccg tttgcggaag 2586721 ctttacctca gtgtctaaaa tcgccgcaac ctcgtaagca acaccaagca tgttcatggc 2586781 atccgcgcgg tttggcgtta aacccagctc aagaatcgca tcgtcaagct gtaaagccgc 2586841 taaggcatcg cttcctgttt cagcgtcatt cgggaatacg aaaatgcctt ctgcatactc 2586901 cttcgccaca agtttgcttt cgataccaag ctcctgtaag gaacagatca tgccgtttga 2586961 ttcttcaccg cgaagcttgg cttttttgat tttgaaattg cccggcagca ccgctccgac 2587021 tgttgcaact gcgacttttt gtcccttatc cacattcggc gcgccgcaaa tgatttgtac 2587081 aggggcttca gctccgatat ccacaaggca cttattcagc ttatcagcat tcgggtgctg 2587141 ctcgcgctcc agcacatggc cgatgacaac gcctttgatg ccttctcctt tgtattcaat 2587201 tccttcaacc tcaataccgg ctcttgtaat tttttcagca agaacagccg ggtccatgcc 2587261 ttttaaatca acataatcct ctaaccattt ataagaaaca aacatccttg catcctcctc 2587321 ttacgcctgt ttaaactgcg aaataaatct gacatcgttt gtatagaagt ggcggatatc 2587381 atcaatgcca tatttcagca tcgcgatgcg ctcaacaccc attccgaatg cgaagccctg 2587441 atattccttc ggatcaaagc cagccatttt aagcacgttc gggtgaacca ttccggcacc 2587501 gaggatttca atccagcctg ttcctttaca tactgagcag ccgttcccac cgcatttaaa 2587561 gcatgtcaca tccacttcta ctgaaggctc agtaaacggg aagaagcttg ggcggagtct 2587621 gatttcacgg tcttgcccga acattttttt cgcaacaagt tcaagcgttc cttttaaatc 2587681 actcatgctg atgtttttgt caacgacaag cccttcaatt tgcataaatt ggtgagagtg 2587741 cgtcgcatca tcgttatcac ggcgatatac tttacccggg caaatgattt taacgggacc 2587801 tttgccttca tgcttttcca tcgtacgtgt ttggacagga gaagtttgcg ttctcatcaa 2587861 agtttcctct gtgatgtaaa agctgtcctg catatcgcgc gctgggtgtt ctttcggaag 2587921 attgagcgat tcgaagttgt agtaatccgt ttcaacctct ggcccttcct cgactgtgta 2587981 gcccataccg ataaataaat cttcaatttc ttcaatgaca acagtgagcg gatggcggcc 2588041 gccgactgca acagggttcc ccggcagcgt gacgtcaatt gtctgtcctg caagcttctg 2588101 tttcatttcc tcttcttcaa gcttctcgtt tttgtcagca atcgcattgg caatacgctc 2588161 ccttacttcg ttcgcgagcg cccccatttt tggacgttcc tcagcagaaa gcttgcccat 2588221 tccgcgcagc acttctgtaa tcggcccttt ttttccgaga tattgcaccc gaatatcatt 2588281 gacaaccttc aatgagcttg ccgcttctac ttgttctaaa gcttcttgtt ccagctgttt 2588341 tagcttttct tccattttgc atcctccttt tatgtaaaca aaccgtcata tgtctttgga 2588401 aaataaaaaa aacccgtccc ttgtacaagg gacgagttgt ggccgcggta ccacccttat 2588461 ttcagacaga ctgatgctgt cgtcagcttc attgacataa cggaatcaga ttccggttca 2588521 cctttacgcg cagtgtacgc ggtcccggcg acaactcaag aggtgaagcc aatttccggc 2588581 tgcgttaaaa atgctctcag tcagcggcat tttctccctg gaaagcagtt gatcagaaat 2588641 tgaggtcctc tgtcacggtt tttgaaatat tatgttctat tatagagaaa tccaacgctt 2588701 ggcgcaacac tatcctcgca agtgatacac gaggatggca gccgcaaccg caacgtttag 2588761 tgattcagcc tgtccgtaaa gcggcacgta caggttcaaa tccgtttttt ccagcaatgc 2588821 agcatctacc cctgcacctt catttcctac aatgagcgca aaggattcag actgaggaat 2588881 ctcctggtaa ggcgctccgt tttgcagcgc cgtgccgtat acttttacgc cctctgcctt 2588941 caattcgtcc acatatgaag gcaggtttct tctcacaaca ggaatatgga agtgagatcc 2589001 ttgagcagat cgcagtgttt ttccgttaaa ggcgtccgcc gtgccgtcac cgagtacaac 2589061 cgcatccaaa ccggccgcat cagccgttcg aatcattgtg ccaaggtttc ccggatcttg 2589121 aacagcgtca atcagcagca ccttgcgtgc cgttgccagc ttttcttcag gcatatggca 2589181 cacagcggca atctgctgcg gcgtttcggt ttcagtcaca gctgaaaacg catcttcact 2589241 cagcatatag cactggatac cagtctcaag atctgaagga atcctcgttt catcctttac 2589301 aaggatttct ttcacaatgc ccgggctttt caacgcctct tcaacgaggt gttctccctc 2589361 tatcagaaat gtatttgttt ttgttcgttc tttttttgtg tgaagctttt tccaatcctt 2589421 cactttttgg ttttttgccg attctatttg tttcactgtc tatgtggcgc tccttttttt 2589481 aacatgatgt tattatatcg caagaacagc acataataaa ccaggtgcag ggttagaata 2589541 tacgtattac attttagaaa aaggagcgtt ttacatggat cttaatttac gtcatgccgt 2589601 cattgccaat gtcaccggca ataatcagga gcagcttgag catacaatcg tagatgcgat 2589661 tcaaagcggt gaagaaaaaa tgcttccagg gctcggcgtt ttattcgaag tcatttggca 2589721 gcacgcatcc gaaagtgaga aaaacgaaat gctgaaaacg cttgaaggcg gattaaaacc 2589781 cgccgaataa gacatgaaac cgggtgacag cgcccggttt ttttcttata taataaaaac 2589841 atgatgaggg ggaacgccat gtttttacag ccgttattag cgaaaaaaat tattgctgaa 2589901 gttaaaaaaa tgtacgaacg tgaagtcatt attgtaaaca cggacggtct tattatggca 2589961 ggcacaaacg atgagcgtgt cggacaattt catgagggag cgcttatctg cgcaaaagaa 2590021 agacgcagcg tgattattac aaaagaagat gaaacaaggt taaaaggagt gaaagcaggc 2590081 ataaacctcc ctgtattttt tgaccatgat gtgattgccg tcttcgggct gacaggtgag 2590141 cctgcagaga ttcagccatt cggagaactg cttcgaaaaa tgacagaact gttcattaag 2590201 gaatcgcggc acttagagca atcccagtgg cgtgagagaa tgctggagtc ctttatgatc 2590261 gattggctgc aattaaagga gtggtctccc agttttcttg agaaagctca gcttcttggt 2590321 gttgaccttt cttcccggcg ccaaatgatt cttattcagg ggtatgagtg gtcacctcat 2590381 gatattgaac aaatggcacg cagctggaaa tcctcgtacc ctgcggattt gttcatcagg 2590441 tggggaaatg aacggatttt gattaatcat gaagtgccgc agcatgaaca aagggatcgg 2590501 cttttgcgga aaatccttca catttgttcg tttgccaata ccgcaagcag ccaatataca 2590561 gcagctggcg ccggaagggc tgtcgcaagc tccagcctga cagattcata cgagcaagcg 2590621 gaaaaagcgc tggctgtcag ccttaagcga aaaacgccca tatttgaaga ggatctgaag 2590681 cttgatatgt gtctgacgga gatcagcccg ggaacccgaa acgaatttcc gcaaagagta 2590741 ttaggaaagg cgctagagca tcaggaactt atgaatacga tacggacttt ctttcatcac 2590801 gatttgtctt tgaaacaaac cgctgaagac atgcatatac acatcaatac attgcgttat 2590861 cgtctggcta aggctgaaca gctgacggga ttacgttttg accgtaccga ggacgtcgtc 2590921 acgatgtacg tcgcactcta ttttttagat caagatacaa aatagagaga gtttcagttt 2590981 cattttttgt atgtttctcc atggaaggct ttgctttttt tcttttacaa tagattgaaa 2591041 gcgttttttg acagggggat gggtgaaatg atcaccaagg atgtaaagga gcagctgatt 2591101 caggtctccg gaccagaaaa ctttgatgac tcgaatgccg gccgtctcgt ctattcatat 2591161 gatgcgacgc ctcagtatca gtctatgcct gatgccgtga ttgctccgag gaatactgat 2591221 gaaatatcac gcattttaac aatttgcagc gaacatcgag tgccgatcgt tccaagagga 2591281 tcagggacaa acctgtgcgg cggcacgtgc ccgactgaag gcggacttgt gcttctcttt 2591341 aagcacatga accagattct tgaaattgat gaagaaaatt taactgccac agttcagccg 2591401 ggcgtcatta cgttggatat gatccgggca gttgaaagca aaggtttatt ttatccgcct 2591461 gacccgagtt ctatgaaaat atcaactatc gggggcaaca tcaatgaaaa ttccggcggg 2591521 ctacgcggat taaaatacgg tgtcacccgc gactatgtta ttggactgga ggttgttctc 2591581 gcaaatggtg acatcatccg caccggcgga aaactcgcaa aggatgtggc cggatacgat 2591641 ctcacacgtc tttttgtcgg ctcagaagga acactcggca ttgtgacaga ggcaatcgtc 2591701 aaactcgttc caaagccgga aacaaagaag acgctgcttg ccctttatga aaacatcgat 2591761 gccgctgctc aaacggtatc ggacattatt gccgcaaaaa ttatacccgc tacgcttgaa 2591821 tttctcgatc agcctacact attggtgatt gaggattatg ccaaaatcgg acttccgaca 2591881 agcgcaaaag cagttctgtt aattgaacaa gacgggccat ttgaaactgt tgaacgggat 2591941 atggaaaaga ttgaggcgat ctgcaaaaaa ggcgacgccg tatccgttca gaccgcacaa 2592001 acagaggagg aagcgtttgc cctgactgaa gcccggcgtt ctgcactttc tgccctagcc 2592061 cgcctcaaac cgacgacgat tttagaggat gcgaccgttc ctcgctcaga aatcgccaat 2592121 atggttaaag cgattaatga tattgctgct aaatatgata tttccatctg cacctttggt 2592181 catgcgggag acgggaacct tcacccgaca tgcacgacag acataagaaa taaggatgaa 2592241 atggaacgtg tcgaacaggc ttttgccgag atttttgaga aagcgattga acttggcggg 2592301 acgataaccg gagagcacgg agtcggggaa atgaaagcgc cttacttgga aatgaagctg 2592361 aaaaaagaag gcattgatgc gatgaaagcg ttgaaagcgg catttgaccc ccggaacata 2592421 ttaaatcccg gcaaaatgtt tgcgaaagat gccagaaaac gtgtggtggc ggaaagatga 2592481 caacagaaaa agaaatgaaa cagatccaaa atgaatttaa agagcgtatg gatgaaggag 2592541 agttattaaa ttgtatgcgc tgcggcttct gtcttccttc ctgtccgacc tatatcgaat 2592601 cgggatttca ggaaacacac tctccgcgtg ggcgcatcgc cttaatgaaa gccgtagccg 2592661 acggtatgat tgaaccggat gaagatgtcg aacggtcgct gtcactttgc ctcggctgcc 2592721 gcgcctgtga gcctgtatgc ccgtctggcg tgaaatacgg gcagctgctt gaggaagcca 2592781 gagatattat ccaccaaaat aaaaaacact ctcttggtga acgtgtcatg cgaaagacgg 2592841 cttttcacga gctgtttccg catcaaaacc gcatgcgctc agctgtaagc cttatcggtt 2592901 tgtatcagcg ttcaggactg caaaccgctg tgcgaaaatc aggcatgctt cgggtcctgc 2592961 ctgagcattt gcggacgatg gaagctgttc ttcctgatgt tccaaaaagc aaagacatga 2593021 aacatcggcc gcgtttcctg ccttccattg gccccatgaa aaaacgggtc gccttttttt 2593081 cgggctgctt aatggataca atgtttttac cgaccaataa cgccacattg aagcttttac 2593141 agctggcagg ctgcgacatt gtcattccgc ctgaacaggc ttgctgcggg gcgcttcatg 2593201 gacacagcgg tgaaaaaaac acagggaaag agctcgcgaa acaaaatatc gctgctttcg 2593261 aagcattaga cgtggatgca gtcattacaa acgcaggagg atgcggagcc tttctcactg 2593321 aatatgatca tttgctgaag gatgaccctg agtggtcgga acgggctgcc gcttttgttc 2593381 aaaagctgaa ggatttttct tctgttttgg ttgaactcga tttccatcaa atggatctag 2593441 cactcgagac gcctcaggtc gttacctacc aagattcatg tcatctaaga aatgtgatgc 2593501 atacgtcact tgagccccgc cagcttctta aaagcatcaa aggggcggaa ttcaaagaaa 2593561 tggagaaagc agacagctgc tgcgggtcag cgggaattta caacatcgtc gaagttgaaa 2593621 tgtctatgaa aatactggac agcaaaatgg ctgccgtcaa agcaaccgaa gcgatcctca 2593681 ttgtaacagc aaatcctggc tgcctgctgc agatgaagct cggcattgaa cgcgaaggac 2593741 taagcggtaa agtcagagcc gttcacctgg ctgatttgct attagaagca gccgggcaca 2593801 aaacatcatg agaaagccca aaacagacat tgttttgggc ttttgtgcgt tattccatcg 2593861 gactgcaaat ttcgatataa tgtccatccg gatcagcgat ataggcgacc gtctgccccc 2593921 atggtttcac tttcggctcc ccgataatcg atacgccttg ttctctcatc cttttgatga 2593981 ccgcttctac attttcagta acaaacccga tttcaaatgt gtttgaagca gatgtatccg 2594041 gaatgtccag cgccgtgatg tctctggcgc tttcccgggt attaagcgcc aatatcgtag 2594101 accctgtatc aaattcgaca tacgtgccgt gttcagcacg aatcggcagt cctaaaatat 2594161 cccggtaaaa aatgaatagc ccgcttgctg tccgatacgt atagaataag atatttcatt 2594221 gatagattca ttgccaaccc ctctcagcat tttcaatagt ccttctagcc cggtatagat 2594281 gcttccatcc ttaagctcgg atctttccac atctgcgccc attttttcac agccgccacg 2594341 ataatgatga agcctaacac cagcatgatg atagataata cgccattcaa tacactatat 2594401 cctgctgctt caggattgag atacacattg cgcaccatcc aatagcccgc ataattgaca 2594461 gtgacatata aataggcaag cgggataagg caagtcagaa tgtaccggcg tttatcggcg 2594521 attttcagca cgatcgtcgc tccgataatc agccccactg aagccatcag ctgattagaa 2594581 acgccgaaga gcgcccaaat ggaaccgata tctcctgaat acagcaagta cccccacatc 2594641 aaacaggcaa gcgcgctggc aaatacagag cccggaatcc agtctgtttt cttcagcggc 2594701 ttatacacct ccccgaagaa gtcctggatc aaataacggg cgacacgtgt gccggcgtca 2594761 atcgctgtta aaataaagac cgcttcaaac ataatgacaa attggaaaaa gtatgaggcc 2594821 aaatggctga aaaacggcat tccggtaaaa atataagtca tccctaccgc aagcgtgacg 2594881 gctccccctg ttcttccttc taagtccaaa ccgatttccc cgctcaattc aggcaaatgt 2594941 acgacattca tgccaagcgt acggaaaacc tcaggcgtgc tgttaatcgc aaagtaatca 2595001 gcaggctgta aagcggtcgc tgcaatcagc gccatgatac cgacaagaca ctcaacaagc 2595061 attgcgccaa acgcaaccgg cttcatatca ctccatttat tcagcatttt cggtgtcgtt 2595121 cctgagccga caaaggcatg gaacccagag atcgccccgc aggcgatggt tattgagatg 2595181 aacggccaga caggtcctgc cagcaccggc cctccgcctt ttacgaattc tgtaaacgca 2595241 gggaacggaa tggacggatt gacgacaaac acaccaacaa tcaaagcgat aaaaacaccg 2595301 attttcataa agctgcttaa ataatcacgc ggagccagaa gcagccaaac gggaagcgca 2595361 gccgcaaaaa acgcataaac aggaagcgcg attgcaagcg ttttcgtatc tagcgttaaa 2595421 aagtcaccga gcgcggtagt ctgtacccat ggaccgataa agactcctgc cattaaaaag 2595481 agaaagccga ccgttgaagc gagctttaaa tttcccgttt tcttataaaa taagcccaca 2595541 cccatcgcaa tcggaatcgt aatccccacc gcaaatgttc cccatggatt acgttcaagc 2595601 gcatgcaaga caaccatcga caggcccgcc attgtgatcg tgatgataaa cagcatggac 2595661 agtcctgtac aaaatcctgc aacagggcca agctcatcct tcgccacttc cgacagcgat 2595721 tttccgtttt tgcgcatcga tgcaaacaac accacaatat catggacggc tcccccaatt 2595781 accgccccga ttaacagcca caataatccc ggcaaatagc caaactgcgc cgccagaatt 2595841 ggtccgacca gcggcccggc cgctgcgatc gcggcaaagt ggtggccgaa cgaaacccat 2595901 ttatttgtag gcacatagtc tttcccatcc tcaagcgcat gagcaggtgt tggcttgtca 2595961 tcattcactt tgagaacctt caccatcata aatgttccgt ataaacgata ggcaatagcc 2596021 aaaatacaca ttgatgctat cacaattgta accgcattca ttttctccca tccccttttc 2596081 tgtttttcat aaatatatca taatttcatg gtgaaaagcg gtcatttttt cctatacaaa 2596141 aagccggctg gaatgggccg gctcgtggca gttgaaagac aagccggaga gaaatctccg 2596201 gctttgctat tcttatgact gttttttcag gcggatcaca ttccaggaaa gcggcgtgaa 2596261 atgagcagtt aagccgtttt cgctgacaga cgatgatccg ttggaatgcg gaacgacatt 2596321 ttttctgtta tgctggtttg ttgctttgat atcctgatgc tcaagtacga tgtgctctgc 2596381 gatttggtag gattcaaagc ctctgagcga aatctccgtc tccatctgat cctcagcctt 2596441 gtttaccgca aaaatagtga gtgtttcttc ctcttcagag tacacaacag cagcatcaac 2596501 atatggcaca tcagtgaaat cagaacaatc gtacttagga gaagaaataa gcggtttcag 2596561 tgactcgccc cttccgtaaa cagaagcatg catgtatgga tagaaaatcg gctgtctcca 2596621 tgcttctccg cctttttccg tcatgatcgg cgcgatgaca ttaacaagct gtgcaagaca 2596681 cgcaattttc acacggtctg cgtgctgcag catcgtaatg agcagagagc cgactaataa 2596741 ggcatcttca aaattgtaaa tatcctctaa aatcggacgc gcagtgatcc acggctcgac 2596801 ttttttatca gcctcatttg agtggtacca gacgttccat tcatccagag agagattgat 2596861 agttttcttg ctgcgtgttt ttgcttttac atagtcacag gtcgcagcga ctgatttgat 2596921 aaaatgatcc aaatccatag aacgtgccaa gtagtttggc agattgttat cccggtttcc 2596981 gtagtaagtg tgaagagaga tatagtcgac atgctcatac gtatgctcaa gcaccttcgc 2597041 ttcccaatcg ataaaggtcg gcataccgct gtttgagctg ccgcaggcaa cgagttcaat 2597101 tgatgggtca acccacttca tgacctttgc tgtctctgcg gcaagccgtc cgtattcatc 2597161 agctgttttg tggccgatct gccatggtcc atccatttcg tttcctaagc accatgtttt 2597221 gatgccatac ggctgttcat agccatgcga tcttcttaaa tcactccagt aagagccttt 2597281 cggatggttg caatattcaa cgagattacg ggcggcatct atgcctcttg tgccaaggtt 2597341 gacggccata ttgacctcag tgttcacctt ttttgcccaa gataaaaatt catttgttcc 2597401 cacttcattg gtttctgtcg tttgccatgc caagtcaagc cgtctcgggc ggttttcgac 2597461 tggtccgaca ccgtcctccc agttgtatcc ggataaaaag tttccgcccg gatagcggat 2597521 gatgggaacc tgtaattctt tgatcagcga ctggacatct tttctaaatc catcttcatc 2597581 cgcttcaggg tgatcaggct cgtatatgcc ttcatatacc gcacgaccca tatgttcgat 2597641 aaacgagcca taaatccgtt tatctacttc accgatttta tattctttgt ctacaatcat 2597701 tcgcgctttt ttcatcacac gtttcctcct tcattaacct ttgactcccc ctaccgtcag 2597761 gccggagata aagtactttt ggaaaaacaa gaaaatgata atcaccggca aaatcgcaaa 2597821 tactgagccg gatataagca tgtcgtaatt atttccataa gggctcagca agctggacag 2597881 ccctattgga agcgtaaaca tttctttcga ccgaagcaca atcagcggcc acaagaagtt 2597941 gttccagctg tttaaggact gaaggataat catcgcaccg aaagccggtt tcatcagcgg 2598001 tgccataatc ctgaaaaaga tgccgaattc cgtacagccg tccatccttg cagagtccag 2598061 cagatctctt ggaaggccaa gagcatattg cctgaaaaag aaaacagcaa caggtgaaac 2598121 gataaacggc aatatgacac ccgtatatga atcgatcaag tgcagtccga cagtaagttt 2598181 aaacagagga agcatcatca cttccagcgg aaccatcata ataatcagca caagaacaaa 2598241 gatgatattt ctgcccttaa aatcataaac cgcaagcccg tacccgatca tcgaagaaaa 2598301 aaacagagtg agcacagtcg taaaaagtcc gagtacaaga ctgttaaaaa accatttgaa 2598361 ataaatgctg ccgccattaa acagaaatgt gtagttatca aaactcatca cttttggatc 2598421 aatatcaaga ttcagcccca cacgcaaaag ctcagatgac ggctttaatg atcctaaaag 2598481 caaacagaaa atcggaaaaa gatacaatag gctcagcatc ataaaaaaca gggtcagcgc 2598541 aattctataa acgctaaact gaggactgtg ccgcaacatt tatccctccc ccttaaacga 2598601 gcctgacagc tttaatgaaa tcaggctgac aacaaggatc acaatcaaaa gcacaatgcc 2598661 gatggccgct ccgtatccca tttcattgta ggcaagtccc tgctgataca aatatccgac 2598721 aagcgtcaga ccaatattac ccggggaatt attctgccaa aggacgtagc tttcctcaaa 2598781 catcctgaag ccgccgatga tgctgatggt cagcacatat acggttacag gcttgagaaa 2598841 cggcagcgtg atgtgcagaa attttttcat tgtattcgcg ccgtctatat cagcggcttc 2598901 gtacagctct ttcggcacat tttgcaaacc tgctaaaaag taaaggatgt tgattcccat 2598961 ccatctccat gaagcaagca gcaccatcaa aaacatgccg gtatgttcat tgttcatcca 2599021 gttctgaggt gaaaagccga gtttaagtag gatggaattg gccagagacg tttccatttc 2599081 tccgaagatc agccgaaaaa tgatccccgc gacaatggtt gaggtcaatg ccgggataaa 2599141 taatgctgat ttaaatatat ttctaaattt gaccagcttt gaattcagga atatggccag 2599201 aagcaatgga acaggaatca gcacgatcag cgtccaaaag gtgtattcca gcgtattcca 2599261 aagggcggta tagaacgtcg ggttgtttag cgctgtataa ttagacaatc cgacaaagga 2599321 cacctctccc ggcaaaattc tttggaagct catgatgaag acactaatga tggggtatag 2599381 aaaaaatacg agaaaggata aaacgaatgg cgctgtaaac agatagggcg ccgctttttt 2599441 tgaataaaac agatctcgcc agcctgattg tttcgcagct gaaggaacgg gatgaaccgt 2599501 tcccgttttc acaggtttca tgagaacctc cccgctttca ctttttgaat gggattctat 2599561 ttctgtttca gttcacctgc cgctctgtcc aaggcttgtt taggcgtttt ttgctgagat 2599621 ttaagcgcgt cgaacaatac gcttctgttg acaaggtctg aagccttggc aaaatcctca 2599681 tgtaaataaa ttggattgat ttcatccttg atatcgagca gcacagaaaa aatgcctgtt 2599741 ccgttttgga agtaatccgt gtatttgttt ttctctttca attccttgga gctccaaaca 2599801 tcccagcgaa gcgggtcaaa gccgagtacg ctccagagtt ttttatttcc ttcttcagag 2599861 cccttcgcaa aggccaaaaa ctcttttgct aactcaacat gcttggattg cttcggtaca 2599921 acagttgccg taccgcccaa acctgccgag cggtcgcccc cctctttcca tgccgggagc 2599981 ggtctgatgg caatcttccc tttcagatca ggcatataat cgataaatct tcccatatac 2600041 caaatcggca tgagaactga agcagctcct ccttggttca taaagccgta gtattcttca 2600101 ctgtgatgcc cgccgcccgg cgcaggaatc atcgttttat cattgatcat gtcttttaaa 2600161 tattgaagtg tttttacgtt ggtgtcatta ttgaggatca gcttgccgtt tttatcaaaa 2600221 tagcctgagt tttgctgtga aatcatagat aagaacgttg cggaatcatt tgtttccacc 2600281 gttcccatcg gcttcccggt cactttgcgc actttctgtc cggctttatg gtaatcatcc 2600341 catgttttaa tatcgtcagg attgacgccg gcttttttca tcacatccat gttataaaac 2600401 atgaccgttg tccctacatg tgtatcgagt ccgtaaagct ttccgttttt gctgtacaat 2600461 gtcagccgcg cctcaacgaa tttatcgcga tccttttcaa tcagcggagt caagtcggca 2600521 agcggtatgt cagagccctt caaaaagttt gaaaaacggg ccaattcgac atctgcaata 2600581 tcaggaacgc cttctcccgc tattagggag atagataagt tatcgtgcat ttgtccatat 2600641 ggataaacga ccgtattcag cttaattttg cggtcaggat attttttgtt ccattccttc 2600701 accatttcca catagaactg ctcatgaagc ccgttaaatg tccaaaaggt cagctcagtt 2600761 tcacccgatt tgccggatga tttttctgct gaacacccgg caatgactaa tgtcagcaac 2600821 atcatgagca caagaaaaca gacagtcatt tttttcatct gcgttacccc ttccattcga 2600881 ggtgcgggct attcatatag accatggttg atcagcgttt tgttttcatt gatgattctt 2600941 aatccggtgc atcggtctct taaggtgtgc gcgtgtctga aggcattttt gacggaatcc 2601001 tgcccgacac cgatttcgtc aaaatacgca gggcctccgg ctgatctcag ccaatcagcc 2601061 agcacttctc ctctcgggag tgtttgataa gccgattgga tggcttcccg gcggcttggt 2601121 gaaaattcgt tcagcccgtc atcctgagcg agctttctgt atgtgtcagt taataaaaca 2601181 gcggcacagc ccacctttgc cccatgaaga atctgaggcc gttttttctc cattaactcc 2601241 atttcaatcc aatgtgaaat atgatgctcg ccgcctgatg ccggtcggga atgatctaat 2601301 gccagcatga caagccccga tacaagtaaa gactccatca aaacccgtat gccagtttcc 2601361 gttttcatcg caatgtcttc tgtgtgttca atgcaggcag caagcgcctc ctgaacgatc 2601421 ttagctcctg caggcgaata aggctcaccg gcaagatgcc gggatatttc ccaatctgct 2601481 aaagacgtga ttttaccgag catgtcacca aagccagccg ccaccattga ctgcggtgcc 2601541 gcttttaata gatccagatc agcgaacagc gcagatgggg ccttcgtttg aatggttgtt 2601601 ttcgtgccgt ataaaataat cggcgcaccg gctgatgtaa aaccgtctac agatggagca 2601661 gtcggataag aaataaacgg caaatctctt tgaaacgccg caaagcggac gatatcatga 2601721 atcgtgcccg aaccgactgc gatcatgaca tccgttggtt gtttcgtatg gatcagcaca 2601781 tgaatgagcg atcgttcatc agctgtcaca tctccggctt cattttctgg aatgatcagg 2601841 cactcggcct gaaatccttc ttgattcagt cggttttcta aatcaattcc tgcaatgcgg 2601901 tgtgtattcg cgtcgcagac aaggacaata tgttgattgt tttttcgttt tacataatcc 2601961 aaaagcgaat cagctgcttg cttaccgaga acaatttctt caacttttat aggcaacgtc 2602021 ttttctccgg cgttttcaaa agcacgctga acgtcagctg cgatacgatt catatcagaa 2602081 tcccctcctc agccaatttg gttacatcct taatagaatc cagcacataa tccggcgtgt 2602141 acaaacgctg ttcaccctgt ttcgcagaac cagttagcac taaggcgctt ttcatgccat 2602201 aaagcttccc catcgcaatg tcagattcaa tgctgtctcc tataatcatg cattcatgtg 2602261 cggacagccc cattgctgta caggcagcct ccgccatcag ccatgacggt tttccgacaa 2602321 caagttcagt cttcgcttgt gcagaagtct caattgcccc gatcattccg gccacatcaa 2602381 tggcatttcc gtcttcgttc ggaaaagagc ggtctttgtt tgtagcgata atacgagcgc 2602441 cgccggcagc cgcttgaaag gcttgattta aatcgtcgta cgtgagcgtt tcatgaaggg 2602501 agatcacgag ccaatccgct tccttcggtt cgctcgcgtt ctgcacaccg gccagcctca 2602561 gctcgtcaac caagccttgc tccccaagca cccatacctt tgaaaaacga taatgttttt 2602621 tcagaaaagc cgctgtcacg cttgatgaca gaacaatgtc gtttacgtcc gtttcaatcc 2602681 ccgcgccaag aagttttttt ctgcacatgg cacgggagat attcccccgg ttgcttaaaa 2602741 agacgatttt ctttcccatt ctcctaagcg ttttgatcgc ttctcttgct ccttcgatca 2602801 actcatttcc tctgaataca gtaccgtcca agtcaatcag aatgccagcc ggtgacacag 2602861 gcgtatcatg actggccata atacgcattt gctccgtgtt ttcgataaaa atgcttttca 2602921 tgcaggactg tattgattgg ggttacatcc ttgttcagca taatggagtg ataggccatt 2602981 tcggcaaccg tttctaatac aactgcgtta tgaatggcat ttaaggcgtc agtgccccag 2603041 cagaacggtc cgtgattatt cacgagcaca cccggcacct gttcgtaatt atgatgctga 2603101 aaggtttccg ctatgacttt tcctgtattc agttcgtagt catgaatgat ttcttcatcg 2603161 tacatttctc gagtacatgg aatcgcactg tcaaaataat cagcatgggt cgtgcctaac 2603221 ggagggatgt ctctgcccga ttgcgcccag cttgtcgccc attgagaatg ggtatggaca 2603281 attcccccga tattcggaaa ggctttatat agataaacat gggtaggtgt atctgaagaa 2603341 ggtttaagcg agccttcgac gacctctcca tcaaggttca aaacaaccaa gtcatcggct 2603401 gtcaggtcgc tgtattcgac tccgctaggt ttgatgacaa ttctttcttt ttcacggtca 2603461 atgccgctga catttcccca cgtaaaggtt accagctgat gctcttgaag cttcaggttg 2603521 gcagccagca cttctttttt taatgtttca agcatgctcc atcacccttt atcaattctt 2603581 tttggcggca gatgaaaatt gaagattttt gatcgttttc agacgcttca tgacatggtt 2603641 ttcttttccg aaataatgaa ccagctcttt atattcagcg tacaattttt cataaaccgc 2603701 ggcgttttcg gcatttggcg tataagttat atctttcagt tttcccatgt tcgccgctgc 2603761 ctttttgata tcatcgtagc cgcctttttc tttgcctgct gcaagcgcgc cgaaaatggc 2603821 agatcctaag gctggggctt gcggtgaacc agagatttta atgtccatgt ttgtcacatc 2603881 cgcataaatc tgcatgacaa acgggttttt ctcagctatt ccgccggctg cgaacagttc 2603941 ctcaatcgga acaccgcttt ctttgaatgt ttcgataatc atccgggttc cgtaagctgt 2604001 cgcttcaact aacgctctat aaatctcttc aggcttcgtc agcagtgtca tgccaagcag 2604061 catccctgtt aaatctgcat caacaagagt tgaacggttt ccattccacc aatctaaagc 2604121 aagcaagccg ctttcaccag gcgcttgatg gtttgctttc tcactcagca gctcatgaac 2604181 gccaatgttt ttttcctttg cttcctcttg ataagctggc gggacacatg ttttcacaaa 2604241 ccagtcaaaa tgatcgccga cacaggactg cccggcttca tatcccgcat agcccgggag 2604301 aattccgttg tccacaacgc cgcacattcc tggaacgata tgcacctctt caccaagtag 2604361 aacatggcac gtcgaggttc ccataatcat cagcattttc cctggctctg taatgccgac 2604421 cgccggtacc gaaacatgag cgtccacatt ggcaaccgca acagccgttc ccgggagaag 2604481 ccctgtcagc tttgccattt tttcagtcag actgccggct ttttctccta ctgaatgaat 2604541 agaacctgac aatttgtcct ttgtaatcgt tttcattgaa ggatttaatt tctcaaagaa 2604601 atcatctgac ggataccccg ctttttcact ccacatcgct ttataccctg cggtacaatt 2604661 gcttcgcttg agcgagccgc acagctggta cacgatccag tccgcagcct cgatgatccg 2604721 gtcagccgct tcataaatgt gaggcgcttc ctcggcaatt tgcatgacct ttggaatcat 2604781 ccattctgat gaaatttttc ctccgtaccg ctgtaaaaaa gcctctcctt cttcttccgc 2604841 gatttgattg agccgatcag catgtttttg ggccgcatga tgcttccaga gcttcacata 2604901 gctgtgcggc tcctcttcat attcaggcag catgcataac ggctgcccgc tgctgtcaat 2604961 aggaaggatc gtacatgccg tgaaatcaat tccaatcccg ataatgtctt tcgggtcaac 2605021 gcccgtctgt tcgagtaaag acggaatggt tgtttccaag acttcgaggt aatcagcagg 2605081 gtgctgcagc gcccagtcac gcggcagctt ttgacccgtt tttggaagga cggtatcaat 2605141 gacagcatgc ctgtattctt ttacagcagc cgcaagttcc tcccctgttt ggacatgaac 2605201 gagcactgct cttcctgata aagttccaaa atcaacccct attgtgtaag ccatgtgaca 2605261 tccccctcta cttttgaagc cggtaaagcg cctcgttcca ttttaactcg tgtttcagtt 2605321 tatgaattgt cgtatcacgg gaaatgagaa cactttcgat tcccgccatt tccgcccaat 2605381 caagcatttg ctccgctgtc agttcataag acaggcaggt atggtgtgca ccgccggcta 2605441 aaatccatgc ctccgctgct gttttcaatg acggctccgg cttccagaga acacgggcaa 2605501 ccggtaaatt cggcatgtct ttttcaattt cctggccgtt gacttcattc agcacaaggc 2605561 ggaaacgccc gccaatatca acaatgctag cttgaatggc agaaccgctg atgccgttaa 2605621 ataccaaacg cgcagggtcc tctttgccgc caatcgaaag cgaatgaacc tcgattttcg 2605681 gctgatccaa agcgacagtc ggacacactt caagcatgtg agagcccaga atcatttcat 2605741 ttcccggttc aaaatggtac gtgtaatctt ccatgaagga agttcttttt cctttagcca 2605801 tgattttcat catccgtaca agggccgctg tcttccaatc tccttcaccg gcaaacccat 2605861 agcctttctc catcaggcgc tgaacggcaa gtcccggcag ctgtttcatt ccgtgcagca 2605921 cttcaaacga tgtcgtaaac gctgtgtatc cgccttgctc aagaaaagcg gttaatccaa 2605981 gttcaatttt cgcctgttct ttaatggacg ctacctttgc ttcgtcacgt tttgtttcct 2606041 cactgatcac atatagtctg tcatactcgg cataaagcgt gtcaacctcg tcgtccgtaa 2606101 tgcgatccat cacttcaacg agatccccga tgccatatcc gtcaacctgc cagccaaatt 2606161 gaatatgcgc tcccaccttg tctccgtccg ttaccgcgac atgacgcatg ttatctccaa 2606221 atctggcaac cttaatatgt ctgctttcat ttaatgcagc cgccgtatcc atccactggg 2606281 acatttcttt tttcacttct tcatcatccc aatagccggc aatgactttt cggctaagcc 2606341 ccattctcga gttgatgtaa ccgtactctc gatcgccatg cgcggattgg ttgctgttca 2606401 taaaatccat gtcaatcgta ccccacggga tatcgcgatt atattgggta tgcaaatgca 2606461 taagcggttt ttgataagag gaaaggcctt ctatccacat ttttgcaggg gaaaatgtgt 2606521 gcatccatgt aatgatgcca gcacatgtct cactgtactc cgcttctctt aacagctctc 2606581 taatggtttc cggtgaagtg acgacgggct tatgagtgat tttatatctg gaagaaatcc 2606641 cgctgagccc ctcacaaatg cttttagcat gctgatctac gagttccagc gtctcttccc 2606701 cgtataggtg ctggcttcct gtcacaaacc agaattcata atcctttgtc tgaagcatgt 2606761 aaactgcccc tttctcataa aataaaacgc tttcaaatac aaaagatacg tactaatgat 2606821 agaaaataaa cctataaata aatatttgta cgaacaattt tattatagta attgactatt 2606881 atactgtcaa tcttttcttt taaaaaaagc cgggggcaga gcccggcttt ttaattcaat 2606941 aggacggcca gcccgagctc caattcaaat cattgatgag aagctttgga atgccgttgt 2607001 cattggcatc ataggcatgg cgaacaagaa tgtttccgtt cacaatatcc tggcctccag 2607061 gtcctttcca ttggtcattg cccgaatcca aaatggtgcc tccgccttca agcatgcttt 2607121 ttccgctttt atcaagataa gggcctgtaa tgcttttgga tcttccgtaa gcaattttgt 2607181 acgtactgtt taccccgtca cagcatttat caaatgaaac cattaaatag taatatccat 2607241 tttgatacgt aagagtagga gcttctaagg cacctccatt attcggtcta gctgcaatcg 2607301 aatagagcga gcctgtaggc ttcattgtac tcttatcgag cttagtcagc ttaatgccgc 2607361 tccaaaacga gccgaatgca agccacgggt tgccatcctt atcgaatgtc agctccggat 2607421 caatggcgtt ataattattt gagcttgtcg aacggatcac caagccctcg tccttccagc 2607481 cccccgaact gatgcttgtt gaagatgcca ggccaatggc agatgtattg cttccaaaag 2607541 aagaaacgga ataatatagc cagtacttgc cgttatagta ttggatgtcc ggcgcccact 2607601 ggttttggcc ataattcggc acataattgg accaccacga tagcggtgta gtgaaaatgg 2607661 atttttgtac ggtccaattt ttagcgtctg aagacttcaa aacccgcagt ccccgttctt 2607721 cagtaagccc tgttccgagc gcataccatg agctcccctc tttaatcata gtcgggtcat 2607781 gaagcagctc attggatgca ccccaaaacg ctgcctctgc gggagcagca gaagtgaata 2607841 tcaaacctgc agccagagct gcactcgaaa agtgtaagaa gcgtttccat gtttttttct 2607901 ttttcaattt tgttcaacct cctttatttt agaaagcgct tacaaattag attatttatc 2607961 ctcccttcct gtcaaatcga ctgcgtatcg tatatcgtca tgttcaggaa attttcggta 2608021 tcccctttat tgtagtcact atgctgtaat ttgtacagac aaaaaaatag aatccacctc 2608081 aataggcgga ttcttccgta tctttattgg tacgtaattt cgtcaaccgt ttttcggtct 2608141 aacttcttaa tgacttctgt aattaacttt accgcgtttt cataatcatc acgatgcagc 2608201 atggccgcgt gcgtatgaat gtagcgggtt gcaatggtaa tggacagcgc aggaacgcca 2608261 tttgccgtca aatggatggc acccgaatca gttccgccgc cggcaatggc atcaaattgg 2608321 tacggaatgc cggcttcctc cgcagtggct acaactgcat cgcgcaaacc tttgtgagag 2608381 accatggatg catcgtaaac gataatctgc gggcctttgc ccattttgct ctgcgcttcc 2608441 ttctcggaaa tgccaggcgt gtctcctgct atccctacat caacaccaaa cgcaatatca 2608501 ggctgaatgg tgtgtgcagc cgttttcgct cccctcagcc cgacttcctc ctgcacggtt 2608561 ccgacgccat acactatatt tggatgatct gtgttttgta agtttcttaa cacatcaata 2608621 gcaatcgcac agccgatgcg gttgtcccag gcctttgcga gtaggaattt ttcattgttc 2608681 atgaccgtaa attcaaaatg cggaacgatc atatctcccg gaagtacacc ccactccaag 2608741 gcttcttccc ggcttgaagc tccaatatca ataaacatgt cttttatttc cactgatttt 2608801 tttcttgctt caggagacaa aatatgaggc ggcttagatc cgataacccc tgtgatttct 2608861 cctttttttg tgacaatggt gacgcgctga gcaagcataa cctgagccca ccagccgcca 2608921 acggtttgaa aacggataaa gcctttatct gtgatttgtg tcaccataaa gccgacttca 2608981 tccaaatgtc cggcgatcat aattttcggg ccgttttctg caccagtttt ttttgcaatt 2609041 aaactgccca ggcgatctgt tgtcacctca tcagcaaatg gttctatgta tgatttcatc 2609101 acttgcctta cttctctttc attgcccggt atgccttttg catctgttaa atctttcagc 2609161 atggtcaatg tttcatctaa ttttgccatg ttccaaaccc tccttcatca gtcctgcatt 2609221 cttattatac aaaacatggc gctaaccata cgactatttc acttgaaaat cgggtatatg 2609281 tttttacagc tttcttttag aaaaagtgaa acctttttct atgcttttcg tattacatca 2609341 gatcatcacc ataagggagg tgccttcaca caatgtttgt catggttcta aggattattt 2609401 tgcttgcact ttttgcttat tgtatttatg ccgtggtcaa atatgtcgcg aatcctaaga 2609461 gaaggcttaa gctggcccaa tcaaaagaac atttttatat tattgatgaa caaaacaata 2609521 cccggaagaa ttttcagctg acgtataaag gcgtgctttt tgagggagaa aagcatattc 2609581 cttccaagga tcatccgctg tttattcaca cgatctttgt ctggacagaa tctcctgaga 2609641 agctgaaaca tttctctgca aaagattttg agaacattga agaaaaagtg ctggaacgat 2609701 atccaaattg taagattgac tgggaccagc ccattaaact cgcaaaaaaa gcagaagagc 2609761 gttaaacgct tttctgcttt ttataaatca aacgggctgt agtaaatagc gatgagaatc 2609821 gcttctatta ccagaagaag cggtactccg tacttaaaag aagcgtgttt cgttttatgt 2609881 ctgaaggttt gcatgccaag ccagacaccg agcgctccaa acacgatggc tatcagccac 2609941 agccggtctt cagaaattct ccacttgtgc tgctgcgctt tgcgtttgtc aatgcccatc 2610001 acccaaaaac cgcacagatt aatcaacacc aaataagcag caataatcat gttgcctcat 2610061 cctttatata gaaaaagccg ctctgctgga gagcggctct atatgattac ttgtttaatt 2610121 gagctttagc agcatcagca agctgattga atgcagtaag atcgtttaca gcaagatcag 2610181 caagcatttt acggtttact tcgataccag aaagcttaag accgtgcatt aaacggctgt 2610241 aagaaaggcc gttcatgcga gcagctgcgt tgatacgagt gatccaaagt ttacggaaat 2610301 cacgtttttt ctgacgacgg tcacggaaag catagtttcc agatttcatg acctgctggt 2610361 tagctacttt gtataatgta tgttttgaac cgaaataacc ttttgctaat ttaagaacct 2610421 ttttacgacg cttacgtgta acagttccgc cttttactct tggcattgaa tttccctcct 2610481 aattgttcct tatccgatta cttgatgtta gcaagcattt gtttgatacg tttgaagtct 2610541 cctgcgctta caacagcact cttgcgaagc ttacgctttt gcttttgaga tttgttggcg 2610601 aataagtgac ttgtgtacgc gtgagaacgt tttaacttcc cagaacctgt ctttttaaaa 2610661 cgtttagcag atccgcggtg agttttcatt tttggcatgg gatttcctcc ttattgcttt 2610721 tcgtttttcg gtgcgagcat taagaacatg ctgcggccgt ccatttttgg ttttgtttcg 2610781 actgtcgcaa cctcagcaca tgcttcggag aaacggtcta atacacgctg accgatttct 2610841 ttatgagtga ttgcgcgtcc tttaaagcgg atagaagctt tcactttatc gcctttttca 2610901 aggaatttaa tcgcattgcg caatttcgtg ttaaagtcat gctcatcgat tgtcggactt 2610961 aaccgaactt cttttaagtt aatgattttt tgattcttgc gtgcttcttt ttcctttttc 2611021 tgctgctcaa atcggaactt accgtagtcc atgattcggc agacaggcgg ttttgcattc 2611081 gctgcaacta acacaaggtc aagatttgcg cggccggcga tttcaagtgc ttcctgacgg 2611141 gacttgattc caagctggtc gccattttgt ccgattaaac ggacctcacg tgcacggata 2611201 ccctcattaa ccaattgatc tttgctaata atgagccacc tccatagttt cttcgaattg 2611261 attcacaact cattttgaat gcattttgca ggcaaacaaa aagtgtgggc attataaaac 2611321 acccacacta cgaacatctg tatcaataaa aatgtacggt caacctgcca actacatgca 2611381 tgtgtcaatc aggtgagaag cgggtgcttc tgcttgtgat ttatattcaa ttcaataact 2611441 attctacaca ataccggatc tttagtcaag gacgacttat ccggaacaac ttttacattg 2611501 taacatgggt tttctatgag cgcaagagag aaaaagaaaa tctttcatcc ccacccagaa 2611561 tacaaagaac caacaattcc cccttattac gcaatttaca acaaaaccac cgacaggaag 2611621 aaatgtaaaa caaagttaat ctctgaccga tataaggagc agaagggagc ctgacacatg 2611681 aacaaactga tacagcttgc tttatttttc acattgatgt taaccggttg ctcgaatagc 2611741 agcacatctt ccgaatcaaa agtcgaaacc actgttaaga caacggcagc atttcctcaa 2611801 aaggagctgg agaaagagct aaaaaaacta aaacccgttt cattggacat gaagttcgag 2611861 agtccactcg ctaccgagtt aggaaagcgg aaggcaaaag aggaagctga aaagcaaaga 2611921 caaatcgccg ctgagaaaaa gcttgaaaaa gagcgggagg cgaaacgaaa gaaacagcag 2611981 gaggaaaaag cggagagaca gcgattagca gagcagcagg ctgcagagag acagcgatta 2612041 gccgaagcgg aaagacaagc tgaacttgaa agacagcggc aggcagcaat ccaaaaagag 2612101 cagaaagcga acgctgagaa aaagcggcaa tcgcaggcac aacggcagca gactgaggca 2612161 ccctcatcta atagtcaaga tccaccatct tcctcgagtc agacagataa aaccattcaa 2612221 cagccagctt cagagcttcc tgatgacgat ggttatggtt atgaagaacg aaaaaagtgg 2612281 catgacgatc aagtagaatg gggcattaaa caagggtata tcgatcccga agacgcacca 2612341 taaaataaaa aaagccaagg cattcagcct tggcttatcc tccgatcagc tgcacgaaca 2612401 cagggatgac cagaaccgtt accactccta ctacgacaac agcaatactt gccatcgcag 2612461 cttcaacttc tcccatctca atcccgaccg ctacaccaag tgcatgtccg gatgttccaa 2612521 gagccaatcc tttagaaatc ggatttttca ctttaaacac cttcaagaac aatgctccga 2612581 gcgcatatac gatgacagcg ttaaagatga ccgcaaaggc tgtgatgtcg ctgatgcccc 2612641 cgatgccttt tgataaagga agcgcaattg ccgttgtagc cgcctgcgga agcatgcttt 2612701 tcattacggc cgaatcgaga tgaatgcctt tagcgagcag ataaacaatc gtgacagagc 2612761 agatagagcc ggcaataatg gaggccatga tttgccacca gtacttttta agcttatctc 2612821 tttgtttgta caaaggaatt gcaaatgcga tcgttgccgg ttcaagaaaa aacttaatga 2612881 tctctccccc gttattataa tccgcgtagg aaaaaccgcc gatttttaaa aatgcgatcc 2612941 ccagcaccat ggcaacaaac aaaggagtga aaaggaagaa gcctttcgtt ttcttaaata 2613001 aaaaggtgcc gatgccgaat gcagcaagtg atacgacaat cccaaaataa ggactcattg 2613061 tgctttccat gtgaagaacc tcctgtttcc cttaatggtg aacgagttcg ttattgttct 2613121 gcgggctttg cactgttttt gttttcatgt ccgcttcggt tttgcgtttt ccgctcagcg 2613181 acagaatcag ctgagaaaac aatcccgtag cccccagcaa aataatcgtt gcgagcagaa 2613241 tgacaagaac aatttgcagg ccgtattgct gcatcacacc aagcgaattc ataacagata 2613301 tacctgatgg aacaaataaa aatccgatca gagaggttaa agacgttccg agcgtctcca 2613361 cttgttccag tttaatgact ttcaaacata ataggagaaa taataagacc aaccctacaa 2613421 ccgatgccgg gataggtatt gggacaatag cggcaatcat atttgaaacc agcataatga 2613481 cggcaaaaat aaatgcttgt gttaaaaacc cgtacacttt tttagcactc attttcttca 2613541 cctctttctc tttggtaccc tcattataaa taagaattcc ctgttataaa gcgcttacaa 2613601 gataacatgc cgtatagcgg gtctgagttg cagaatcaaa tggctgaaat gcaaaaagcc 2613661 gcccatcaaa tatggagcag ctttttcaat tccttcgcat atgtccggct gaccggtatt 2613721 ttcgatccgt ctttcatgat cagattatac gttgaattaa accatggctg aatttcttta 2613781 atatattcag tattcacgac aaagctccga tggacgcgga taaaatcaga atccggcagc 2613841 tttttctcaa tcacaacgag tgtatcgctg accgtataag aatgatcgaa ggtttttaca 2613901 ttgacatgac catcttctgt tccggcatag ataatgtcct tcgtatccac aatcacaatc 2613961 gattccccca cagatagcgc gagcttgtgc tggccggcat ggctgttttg ctctgtttct 2614021 acaatatccc gattgacttt tttatatttt ttcagcgttt gctgaattct ttcttcatcg 2614081 aaaggcttgg ttaaataatc aagagcgtcc acctcaaacg ctttgagcgc atactggtca 2614141 tacgctgtcg caaacacaat agcaggagga tgcttcattt tcttcaatcg ctttgcgata 2614201 tcaaaaccgt tttctccgga taaatcaacg tctaaaaaca gcaaatcagg tttttgatcc 2614261 atcatttggt caaaagcgga ttcgatattt tccgcttcat tgatttccat ttcatcattg 2614321 gtccgcttaa gcaagtaagc cagttcatcc cttgccagca tctcatcatc aactattaac 2614381 accctgagca tgttcttctc cctctttcat ctgttgcatt ggcacttgaa aggaaacctc 2614441 tgtcccttta tgaacctcac tgctgatatg cagtgcagcc tgctgtccga ataaaccgat 2614501 cagccgctga tttaggttat aaagcgctgt accggttccc tccttagacg gaaacggttt 2614561 cttccccagt tccggcaaga cgtccggcgg aattccgcgt ccgttatccg ccaccttcat 2614621 atagacggat gcatcatcag ataagacaca gactgtaacc ttgcatatgt cttgtttttt 2614681 cggaaacgcg tgccgaagcg cgttctcgac aagcacctgc aaaacaaacg gagggatttc 2614741 aatctgctcc agtctgctgt cgatattaag ctcaatttta tatttcccgg gaaaacgcgc 2614801 ctgttctaat gacaaatagg cgttaagatg gttcagctcc tttgagagcg gaatcagcag 2614861 ctgtctcgct ccttgaaggt ttgaacgaaa ataaacactg agctgcaata ggagcttacg 2614921 ggttttttca acatctgtac ggcataacgc agaaatcgtg ttgatcgcat taaataaaaa 2614981 atgcggattc acctgtgctt gaagcgcttt aatttcagca tccttgagaa gtttgctttg 2615041 cagctctgct tccccaagct caagctgtgt cgaaaacagc atggccagcc cctcggcaag 2615101 ttcctcctct acctgactca ggcctgccgg gcttttaaag tacattttta aggtgccgat 2615161 tgtattgccg ttcgatgtca gcggtaggac aattgcagcg tgcaaagggc attcagcatg 2615221 cgtgcattca atctcttcct gcgaaatcgc cttcataata tgccctgttt taatcacctt 2615281 tttggacagg ccggtgatca agcttttcga tgggatgtgg tgatccattc ccgcaccgac 2615341 atgcgcaagg atcttttctt tgtcagtgag agacaccgca tctgttcctg tcagcttatg 2615401 gataatagcc gctacacttt tacaggagtt ttcatttaat ccttggcgga aaaatggaag 2615461 tgtctgatca gcaatcgtaa gcactcgatg cgtttcgaga gcccttgcct gttcttcctt 2615521 gcgaatgatc gcttgaataa tagacagaaa aataaaactg cctgttccat tgatgagtat 2615581 catcggaatt ccgatcatgc tgacaagctc ccaagcgtca ctgaacggct ttgccatcag 2615641 caaaataatg atcatttgca gtgactccat gccgattccc acaagagcgg cgatgcgcgg 2615701 tgtcggcatt cgatatcgct tcgtaaaata cctgccgatc aagcctgcaa gaacacccgc 2615761 taaaatagat gagacggcac agcttaaggc cgtgctgcca ccgagtgaaa aacgatgcag 2615821 gcccgcaagt atgccgatcc cagcccctac aaaaggacct ccgagaaggc ccccgatttc 2615881 cacgcccaaa atacgggtat tcgcgataga gcccgatgga tctatcgtaa acacccagtc 2615941 attgtttaca atcatatttc tttgaatttc gatgcctgta taattgctga tgatgctgaa 2616001 aagagaaaaa atagaaatta aaatcgcttt tcctttatag ccgtcctgat tctgaagagc 2616061 ttgtctgaaa agtttcgtat gggcgagaat gaaccctaat ataacaataa tccccactct 2616121 ctccagcatc ataatcatta aatgaatcat tcatgtcacc tgttctttcc gttttcattc 2616181 tagcatgttt tcgttttgcg gctgactgtt tttttaaaat cgtctgaaaa catatttcac 2616241 aaggctttta tctattgtaa aataaaacat gagccttttg gcagaaagat ttgaatctga 2616301 agcagaggag aagatcatga aagccgtatt ttttgattta gatgatacac tactttggga 2616361 cgaaaaaagc gtcagaacaa catttgcaga aacttgctta caggcggaga aaaaatatgg 2616421 ccttgcccct gaggaattcg aagcagctgt tcgcgaagcg gcgagagaat tgtacatgtc 2616481 atatgagacg tatccatata cagtgatgat cggcattaac ccgtttgaag gactgtggtc 2616541 caatttctca gagccaatca gtgaaggctt tcaaaagctg aacaagattg tgccggagta 2616601 cagaagaaat gcatggacca acggactgaa agcgcttggg atcgatgatc ctgcatatgg 2616661 cgaatacttg ggagagtttt ttgcggcaga gcgcagaaag cgcccgtttg tatatgatga 2616721 aacttttgct gtactcgatc aattaaaagg caagtatgaa ttattgcttt tgacaaatgg 2616781 cgatcctagt ctgcaaaagg agaagcttgc cggcgtgcct gagctcgctc cttacttcaa 2616841 tgaaatcgtc atctcgggcg cattcggcaa gggcaagccg gatgtttcaa tttttgaaca 2616901 ctgccttaag ctgatgaata ttgaaaaaga cgatgccatc atggtcggcg ataatttgaa 2616961 tactgatatt ttaggcgctt caagagccgg aatcaaaacc gtttggatca accggactga 2617021 taagaaaaac gaaactgacg taaagcctga ttacatcatc agcagccttc atgatttgtt 2617081 tcctatatta gagaaataaa aaaagcatga tctcttcaat gagatcatgc ttttttattt 2617141 tattttttcg cttcagctac tgcctttttc acaaactcat caagtgaaat ggtttcagag 2617201 ttctgttctc cgtatttacg cacgtttacc gctccgtttt ctgcttcttg gtcaccgacc 2617261 accagcatgt acgggatttt ttgcatttgc gcttcacgga ttttgtagcc gattttttca 2617321 tcgcggctgt cgacttcaac acgcaggcct tcacattgca ggcgttcctg cacttttttc 2617381 gcgtagtcta aatgcacagc cggagaaacc gggatgactt ggaactgaac cggtgcaagc 2617441 catgtcggca gcgcgccttt gtgttcttcg attaagaaag caacaaagcg ttccattgtt 2617501 gaaacgacac ctctgtgaat gacaaccgga cggtgctgct tgccgtcctc accgatgtat 2617561 gtcaggtcga aacgttccgg caataagaaa tcaagctgaa ccgtagacag tgtttcttct 2617621 tttccgatcg cagttttcac ctgaacatca agtttaggtc cgtagaatgc cgcttcacct 2617681 tctgcttcgt aatagtcgtg gccgatttca tccattgcct ctttcagcat ggattgcgct 2617741 ttgttccaca tttcatcgtc atcaaaatat ttctctgtat cttccggatc gcggtaagac 2617801 agacggaatg tgtaatcact taaaccgaag tcttcataaa catcctggat taaacggact 2617861 gtacggataa actcatcctt aatttgatcc gggcgcacaa agatgtgtgc atcatttaac 2617921 gtcattccgc gtacccgttg aagtcctgac agcgcacctg acatttcata gcggtgcatc 2617981 gttccaagct ctgcaatacg aatcggaagc tcgcggtaac tgtgaatgtc ttgtttgtaa 2618041 atcatcatat ggtgcggaca gttcatcgga cgcaatacaa gtgtttcatt gtccatttcc 2618101 atcggaggga acatgccttc ctgataatga tcccagtgtc ctgatgtttc atacagctct 2618161 ttgctgccta gcacaggtgt gtatacgtgc tcatagccga ggctgatttc tttatcgaca 2618221 atgtagcgct cgatgacgcg gcggattgtt gcgccttttg gcagccaaag cggcaggcct 2618281 tgtccgactt tttgagagtt cgcgaacagc tttaattctt tgccaagctt tctgtggtcg 2618341 cgttctttcg cttcttctag catacgaaga tgctcttcaa gatcagcttt tttgaagaaa 2618401 gctgtaccat atacgcgctg aagcatttgg tttttgctgt caccgcgcca gtatgcgcct 2618461 gcaaggctta acagcttaaa ttctttgatt tttccggttg aaggaacatg gacgccgcgg 2618521 cacaggtcaa agaattcgcc ttgctcatag atcgaaacgg tttctccttc aggaatcgca 2618581 tccaatagtt caagcttcag gtcgtcgccg atttccgcaa aacgggcttt cgcttcttca 2618641 cggctgactt cttttcgaac gatcggaagg ttcgcattaa cgattttttt catttctttc 2618701 tcgattttcg gcagatcctc cggtgtaatc gcttcgtcca tttctacatc gtagtaaaaa 2618761 ccgttttcga taaccggacc gacgccgaat ttaacatcct tgtagatgcg tttaatcgct 2618821 tgagccagca agtgagccgc actgtggcgc ataatttgaa gaccttcttc tgagccttct 2618881 gtaatgattt ccactgtacc gtcttcattg atcggcgttc tcaaatcgat ttcttttccg 2618941 ttcagttttc cggctaatga ctttttcttt aatcccggac tgatggatgc cgcgatatct 2619001 tctgttgttg ttcctttcgc aaactccttg actgctccat caggaaatgt gatttttacc 2619061 atatctgaca tctttgtcac tccttttttt gcatataaaa accccgcccc ctatgaaagg 2619121 gacgaggttg aataaacgga atcgtggttc cacccttttt tccgcaaagc caatacacgg 2619181 cacctgcggc tctaagctct gtaacgggag ttcccgtcag ccattactgt tccttttcaa 2619241 gaggttcaca gctgaagttc aaaggcggta aagcgaatgg tccttagctg ggaagcttgc 2619301 agccagggct tccctctctt tgagccggta tcattccttc gtgtccttat caatacgtgt 2619361 gtctttctta atctcctatg tattataaat tgttcaatcc aaaaaatcaa cacgatcgcg 2619421 tttccttttt tttaaaccga cagccttaaa tagacaggct gccggccctc atccttccga 2619481 gtgcttcacc ggtatttctg catctgtaaa agcatgcagc gggagcattt ccactctctc 2619541 ttgaaatacg ttttgaatgg tccttgccat catgtgctcg ggctggtcgg tataaagcac 2619601 gacttcatca ggcgcaatgg aaatcagcgg cgcgagcaaa tgagaatcaa tatacatagg 2619661 atgatcccgg acaaatcttc tgtctatgta tttcattttt tcccgttccg gcacatagcg 2619721 cagctcccat aatgtaaagg aaccatcatg gacaatatgc acttttttga ttcgcggctg 2619781 tttggcgtcc acatagtctc tgagtgtttg aataaagttt tgatattcct gttccatctt 2619841 atattcatca atcgctgctt ctgtaatatc tctcagctgc ttatagtatg atccaagtcg 2619901 gaaggtctga aaggagcgaa tgtaaaatac tccttcctct aaacagatcg tttggagttc 2619961 atccaaaatt gattgtttcc gtgaaagctt cagcggctca aacggaagat cgtctgcttc 2620021 accttcaata atactgtgtg cgagctgaag gatttgctgc tgttcatcct ggtccgtgaa 2620081 acaatacgtt tcctcaatca atgacagcat atgctcgtct tctttgcatt ccaaaaaaaa 2620141 tttgaccaga atcggctcca taaaacgctg aataggaaaa gccggattcg ctttttcaat 2620201 cccgattttt cgtatgcctt cacggacaat gatattgttc cgatcgtccg aatgctgaat 2620261 gagatgtaaa aaagcggctg catcatggtc atcttcaaag attatttcaa gcatgtttgt 2620321 ccccccttac ggcatctgtt acaagtatat gggggatgtt tttaaaatag acgtaaaggt 2620381 cattggcaaa tcttaatttg attcttggaa caagttttgc attttctttc tgaagatgaa 2620441 cggcaatgag ataaacacga tatacaaagc gagcaccata aagaaagcgg gcagattgcc 2620501 agccaaaaag ctcgcaccca gcacattaag cgcaatcgtc ccagggatga ttcccacagc 2620561 cgttgcggca aaatacggca gcgctttgac attggaaagg cctgccgcat agctgacgaa 2620621 atcaaaattg atcggcagga ttctcaaaag aaagatatag aaaaatccgt tatcctccat 2620681 ttgcttctgt atggcttcaa gcctttcgta atgcccgttc tttttcgccg aaaacaaacc 2620741 agccgcaaaa aacgaaacag ctgaagcgca catcgaaccg aataacgtat aaagcgtgcc 2620801 gagaagcggg ccaaacgcaa gtccgccagc tattgaaata acagacaccg gaaataaaac 2620861 aagtggcctg acgatggata tcccgataaa catcagaggt gcaaagactc cgaacgacaa 2620921 tacccatacc ctgatttctt tcggcgatac attcaaatac gttttatttc cccaatagag 2620981 taaaccagca cctgcaagca ctgccagcca tttgacagcc gtttttcgtt tcataccctc 2621041 agttccttcc cctttgaacc acagcaatta tggatgtcgg cggttttctc cgtcaaggcg 2621101 gatcggagca gccaaatata atatccgctc cattaatctt gcagctttta cttcttcttt 2621161 ttctcccctc tgcgaatacg taaaatgatg cttcagctcg tcaggtgaga aattagaaga 2621221 aaagaacgtt ggcagctgct gggacattct gtgctgaagc accgttccga tgacctcatc 2621281 ccttacccag cttgtcattg attctgctcc gatgtcatca agcattaata cgggtgtggt 2621341 ctttaccata ttgagcttct cttccaatgt ctggtcttgc agcgaattct taagctctct 2621401 cacaaattca ggcacataaa caatcatgga ggaatactct ttttccgcca gctcattggc 2621461 aattgcagcg agcataaacg tttttcctac cccaaatttc ccgtataaat ataatccttt 2621521 cccttttccc gtctcattat agcttttcag gaagtctgta acatgctgaa acatcgcgag 2621581 tctgcttggg tcactgatat caacttgctg gaacgtcgct ccaagaagat cctgctggat 2621641 atacatgctt ttcataagag actgttgttt cttctgctgg tcgagcttcc gtttgactgg 2621701 acattcgtaa tactcgatat caatagacct cccattgaca acaagcttcg gatggtagcc 2621761 ctccaacaaa ttgttgcagt tttcatcttc cgaacaatag gagcaattct tgctttgttc 2621821 gatatattca taaagcttat ttaagctctt ttcgatcatt ttttggtcaa tcacttcttc 2621881 gttttccttc aaaaatgctt gaacatcttg atctttcatg actttttcct tcatttgttc 2621941 aagacgtttt tggaaatccg gcctgccggt tacgccctgc agggaacggc cgattggttc 2622001 catctattcc ttcaccccgc atctctgtct ttaataggca gagtattttt tcagtttttg 2622061 catttcttcc atcatctttt tcttctgttc ttccaaatcc tgcggatgca gcttctgctg 2622121 tccggattct gaatcggacg ctgtttcctt ttctgtcatc caatcaggaa gcttttcttc 2622181 acgaatcact ttttggtttc gtttcgaaga ctttgttttt ccctcagccc attcaagata 2622241 ctggcggttt tcttctattg cgagcttcat cgcttccctg accgttttca cctttttgcg 2622301 tgcccaatgc gaagcgattt tttggatata gtttttcgac agcttcatgt cggttttcag 2622361 catgacataa taaattaaca catttgtgac gcctggctcg agcttctgtt cgaacataat 2622421 ttcttctatg atcttcagat cagcttttga cggctctgtt ccgtcagcaa tgtcctgcag 2622481 aagcttcttc ggggaaatcg cctccagcaa tgcaatcagc ttcccatcca gagaatcctc 2622541 ttctgccggt tgttcgcctt cacgcagatg caccggctgt gttttttcca ccaaatcggg 2622601 cagctgtccg tttctttcaa tttgatacca gtcgctcgcc gcttttctta atgcctccgt 2622661 cgtaatgacg tcacgctcat caattgcgct catcacaaca ttttgcattt gcaaagggtc 2622721 aattccgtac agataagaaa gctttttgat tgtgtcccgc acctgctggg tcatcgcttt 2622781 tctcggtatc atcgtctcag aaagtcccgc taaaaacaaa tcaaaatcaa acacatcctc 2622841 cgttatggtg taggacggag actgtccgac agaagtatac tcggacccct cggcaagcct 2622901 taccgtttcc tccatatcgg atgtgagctt ccattcactc ggctgcagcg attcaaacgc 2622961 atgattaaac ggacgcgtaa tgtccttcgc atcttctgaa atggccgggt gcgtaaaaaa 2623021 ttgttttaat tgctgatatt tcgtttttcc gaccctatta tacagaaaaa cattcagcat 2623081 tccgtcttca aaaaattcat ttggtctgag cggcggaagg agttcatata taaagaggcg 2623141 ctcctgccgc tcggattctt tcatatatac tttcagcaat ccgatgccct cgagcttccc 2623201 ctgttcctga tggatcgttt ttaagttgga ctgtgtcatc cccatcagct gtctatgtgt 2623261 ggactctccg ccccacagac ggttttgttc aagctctccc cacaatgtca tataaagaga 2623321 gaatgcaaca gggccgatta agggctggta cagttgtgta ataatttgtc tgtcaatatc 2623381 ctgcagcatc gatctgcttt taaccacata cgggtctaca ggcagtacat ctttccaata 2623441 gtcagccata cattctcaaa ccttccgaat ttgtttctac ctttcatttt acaccgtttc 2623501 ttatatctat caaatgccaa ttttgcacat gagaaaagag ctagaagaat cctcttagct 2623561 cttttaacgc tctttcttta ttaagtcttt taattcatcg ataaagacgt ttatatcttt 2623621 aaactgccga tagacggacg cgaaccgcac atatgcgact tcgtcaatct tagccagccg 2623681 gtccatgacc atttctccga cgagctcact cttcacctcg gagcagcctt gattgcgaag 2623741 ttctttttca atatcaaagc acatgtcttc aagcgttttg agtgaaacag gccttttttc 2623801 acatgctttt atgaggccgc gcagcatttt ttctctgctg aattcctcac gcacaccttc 2623861 ttttttcaca acgatgagcg gggtttcctc cactttctca aaggtcgtaa accggtagtg 2623921 gcaggattcg cactcgcgtc ttcggcgaat cgactttccg tcatccacag gccgtgaatc 2623981 aaggactcgt gttccgttat gctggcatga aggacatttc aataaaatca gctcccaact 2624041 atatcgttcc ctgcaatgta ttttcggcag cctccgcctt ttaaaaatag atgtgacagc 2624101 atctgtcggg agagccgttg ttaaatttgt ttctatagca ttaggtggtt tgtgaaaatc 2624161 tccttcttat tttacaaaaa aaatgaaaaa agaaaaagct gacactctcg tttctttata 2624221 aaaataaaag gagcataagc taaaaagcgc ataatggctt tctagcttca gctccctttg 2624281 tgttcgcaat ttactttata gtactttcgc ttgcgcctgt ttaatttgca caggccccat 2624341 tcctcttggt atttcaatgt tttctcttgt atcagcatgt aatgcctctg caatgtaatc 2624401 agcagcgaca ttaggatcta agtctccaca agtataaaca tcaatgctcg catatccgtg 2624461 ctcaggaaaa ctgtgaatcg ttaagtgtga ttcagaaata atcacaactc cgcttacgcc 2624521 ttgcggtgca aatttgtgaa atgcaacctc gcgcacctca gcacctgatt ttagagcagc 2624581 atttacaaac gttttttcaa taaaatccat gtcattcagc ttatcaaaat cgcatcccca 2624641 tagctcggag ataacgtgac gccccattgt ttccatagtc atggaccccc cttaacaaga 2624701 attaaaaagt gaaattccaa caactgggtc ggccatttac cacgggggaa agttagtccg 2624761 gagaggtcct aaccctttaa gtaattccga aacagtctca agcaagaagt tcacgaaaaa 2624821 tagtatactg tgtttaagtc taatttgcaa ggtgcgtttt ttcagaaata tgctgttaag 2624881 ggttttttct ttaaaatgtg tccatgacct tattttatac agcagacgga tgtttcattc 2624941 gtgccgctac atggcggatt agatcaacaa ctctgcagga gtagccccat tcgttgtcat 2625001 accacgccag cacctttact ttcctgtctt ccattaccat tgttgtaagc ccgtcaatga 2625061 ccgctgaatg cggattcgta ttataatcag tcgaaacgag cggttcatct gagtaatcaa 2625121 gtacaccgta catcgacgtt ttggcagcgc gtttaaatgc ctcgtttact tcttcagccg 2625181 taacatccgt tttcagatca acaacgagat caaccaatga gacgttcgga acagggacac 2625241 gcaaggcgag gccgtgaagt tttcctttca gatgcggcag cacaagcgaa agcgcctttg 2625301 ccgctcctgt tgttgttgga atgatggatt caccgcaagc ccgcgcccgg cgcaaatctt 2625361 tgtgcgggtt atcaatattt ttttggtcat tcgtatacgc atgaactgta gtcatcagac 2625421 cgctctcaat gccaaactct tcatccagca cttttacaac aggcgcaagg caatttgtcg 2625481 tgcatgacgc atttgaaata atgacatggc gctcagcgtc gaattggtcc tcatttacgc 2625541 ccatcacaat ggtaacgtct tcattttttc ccggagcggt caaaatcact ttttttgcac 2625601 ctgcttctat atggcccatc gctttatctt tagcattaaa cttccctgtt gcttcgacga 2625661 ctatgtcaat atcatattcc cgccaaggca gctgttttgg atcacggctg tttaacaaaa 2625721 gcactttctt tccatttacg atcaggctat cttcaccagc cacaacctct ttgtcgtatc 2625781 tgccgtgaat tgtgtcatac tttattaaat gagccagcgt ttctgcggaa tagctggcgt 2625841 taatggccac tacttgaatt tgatcgtcta acatcgcttt tctaaaaacc attcttccga 2625901 ttcttccaaa cccgttgatc gctactttta ccttcatgtt ggacacccct tatcaattat 2625961 gccatcctaa tttgttacta tctaaaatta gtataacaca ttaaaacaaa ttcgccagta 2626021 catattgata aaaatcaacg attataacgc taatttatga tgcatcttat gttttcttgc 2626081 acagaatatc aggcgtaaga accaaaaagc agccagcgct ccgcactgac tgccctcatg 2626141 ctttatgatt cctgttttaa cttatcattg agcacacttt cttctagcac agaaaatgta 2626201 tccccgtaca ctctgttaat atgattcgct ccccaagcac acagcatatc taaaatccct 2626261 tctaagctgc ggccgtattc gctgagctcg tattccactt tgggaggaac ttgattatat 2626321 acgattcggt taatgacacc gtccgcttcc agctcgcgca gctgctgagt cagcattttt 2626381 tgcgtgatat tgggcattag gcgttttaat tcacttgtgc gtttttttcc gtgcgtcaga 2626441 tggcataaaa tgacgcattt ccatttccca ccgatcactt caagagtcgc ttcaacagaa 2626501 atgttatatt ttttcttctc catacaatcc attctcctca caggcaccaa aaagtgacta 2626561 tagcacttca aagtacgtac ttttatttct taacgatatg tttcataatc acatttgccg 2626621 gctgatttga atctgctctt ttttatttat atagcttact cggcagaatt tcaatcatac 2626681 aacacatctt acaaaggagg aacatcatga cttcagccaa taaaagcaat attcctgcac 2626741 tactggcttt ggccgtaagt gcattcgcaa tagggacaac tgaatttatc agtgtcggcc 2626801 ttttgccgct cattgctgat gacctggata ttcccgtcac gacagcagga ttgaccgttt 2626861 ccctttatgc gctcggcgtt acatttgggg cacctatatt aacttcattg acctcaagca 2626921 tgtcacgtaa gacactattg ctttggatca tgtttatttt tattgccggt aatacgatgg 2626981 cagcaaccgc ttcaagcatc gggattttac tagcagcacg tgtgatatcg gcattttcgc 2627041 acggtgtgtt tatgtcgatc ggttcgacaa tcgcagcgga tattgtcccg gaggataaaa 2627101 gggctagcgc gatttcaatt atgtttactg gcctcactgt ggcaactgta accggagttc 2627161 cttttgggac atttatcggc cagcagttcg gctggcgttt cgcctttatg gtcattatcg 2627221 ccgtcggaat cattgctttc attacaaatg gcattcttgt accgtccaaa ttacgaaaag 2627281 ggacgaaaac aacgatgcgg gatcaattga agcttgtgac aaacagccgg ttattgcttt 2627341 tatttgtcat tacagcgctt ggatacggag gaacattcgt tgtgttcacg tatctgtctc 2627401 ccctgcttca ggaagtaaca ggcttcaaag ccgggactgt tgcagtgatt ctgctcggat 2627461 acggaatagc tattgctatc ggcaatatga ttggcggaaa gctgtcaaac cgaaatccga 2627521 ttgccgcttt attctatatg tttatcgtac aggcaatcgt tctattcgta ctgacattta 2627581 cagccccgta tcaagcagca gggctcatta ccattctctg tatgggattg ctggccttta 2627641 tgaacgtgcc cggccttcag gtgtatgtcg tcatgctggc tgagcgtttt gtcccgagtg 2627701 cagttgacgt cgcatccgcg atgaatatcg ctgcctttaa tgcagggatc gcgcttgggt 2627761 cataccttgg cggtgtgatc accgattcaa tcggattgat tcataccgct tggataggcg 2627821 gattaatggt ggtcggtgca gtcattttaa caggctggag ccgcttgatg gaaaaacgag 2627881 atcggcagga agcctgacaa ttttaaagga ggaaataaac atgacaacac atttacaagc 2627941 aaaagcaaca cttcataatg gggtagaaat gccttggttc ggcctcggcg tgttccaagt 2628001 ggaagaagga tctgaactgg taaacgcagt taaaactgcc attgttcacg ggtaccgcag 2628061 tattgatact gcagcaatct atggaaatga agctggagtc ggagaaggga ttcgggaagg 2628121 cattgaagaa gcaggcattt caagagagga tctgtttatc acatcgaaag tatggaatgc 2628181 ggatttaggc tacgaagaaa cactcgccgc gtttgaaaca agtctgtcca aactcggtct 2628241 ggattatttg gatctatacc tcatccactg gcctgtagaa ggaaagtata aagaagcttg 2628301 gagagcgctt gaaacgctgt ataaagaagg ccgtatcaaa gcgattggcg taagcaactt 2628361 ccaaattcac catcttgaag atctgatgac ggcagctgaa attaagccta tgattaacca 2628421 agtggaattt cacccgcgcc tcacacaaaa agagttgata agatactgcc aaaatcaggg 2628481 catccagatg gaggcttggt cacctttaat gcagggacag ctgctggatc accctgtatt 2628541 ggctgacatc gctcaaacat ataataaatc tgtcgcacaa attattttgc gctgggatct 2628601 gcagcatggc attataacga ttcctaaatc aacgaaggaa caccgcatta aagaaaatgc 2628661 aagcgtattt gactttgaat taacgcagga tgacatgaac cgaatcgatg cactgaatga 2628721 aaacttgcgc gtcggtcctg atccggacaa ctttgatttt taatggccaa aaaacaccgt 2628781 tcaatatgaa cggtgttttt tgtattatgc ccagctgttc atgatttcat caagctgcct 2628841 tttggtctct tcaagcgtgc cgctgttatc aatgacttga tctgctcttg ctgttttttc 2628901 ctctaagggc atttgagagc ggatacggct gactgcttct tcttctgtca gctgattgcg 2628961 cttcatcaga cgttccagtt gaagctcttt tgtcacactg accacaataa ttttatcaac 2629021 caatgattcc aatttgcttt cgaacaatag cgggatatcc aatacaacaa atgcctcccg 2629081 atttgcaacg gcttcatcac ggcgattgag catttcctgc ctgactgcgg gatgaacaat 2629141 tgcatttaaa gcgagacgtt tttgttcatt tgtaaatacc agcgctccaa gcttttttct 2629201 atctatatcg ccatttgaga gcagtatgtc ttcaccgaat tcgtcaatga tttgccggta 2629261 ggccggcatc cctttttcta ccgcttgttt tgcaatgata tctgcatcta taactgttat 2629321 tcctttttca atcagcatat tggctaccgt gcttttgccg ctagctattc ctcccgttaa 2629381 accaatgact aaggtcaaga gatccactcc tttttacaat ttccagagcc caatcgtgat 2629441 taatagaagc cccggcaaaa acgccatttt atcgatccat ttccacttag acagaaaatg 2629501 gccggcattg attccaattg atacaaacag cgagctcatg attgccacgg cgatgctcat 2629561 cacaatcggc gaaaaaccga gaatggctgc gcctatacct gctccaaagg catcaatcga 2629621 taaggcaaat cccaataaga ccgcctcaat tccgttgatc acacccgatt tgtcgatatc 2629681 cgcactcatg ggttttctca aaatatgaat cacaattcct aatgaccgaa cctctagatt 2629741 aagcagtgtt ttttcatgca ataggtattc tttatctttt gccggtttga aaaattgata 2629801 cagaacccac gcaccgattc caaccaatat caaaccgcca agcttctccg tcacatatac 2629861 aggaaaaaac ttcgtgagaa agcttccgat cagcatggat ataaacatga cagcaccgga 2629921 acagcaggcg ataaccaaaa tcgctttaaa cggtattttc atttttctca atccgtacgt 2629981 aaatccgact gaaaaactgt ccaagctgac agccaacgcc agcagcagta tagaaaccat 2630041 ttgcatatcc gtttcttcct ttctgttggt gctcttgtat cagatgtgaa atgcccggga 2630101 ttcatcacaa tcatatatat gggaaagtga aaaatccgtg tttcgaaaat ggcatcctta 2630161 atccagagtt actgatatat gcaccgacag cttggacaat gaagcattat gctacttttt 2630221 tgtctggcac tttgcgcaaa aatgcgtgcc tcttcctcca acgacaattt tcgaaatcat 2630281 cgttccgcaa tttttgcatg gctcgtcttt ttttccgtac acaaaatgct gcagctggaa 2630341 cattccgatt tccccttggg agttgatata tgaacggact gtgcttccgc ccgcatcaat 2630401 cgcctcctgc agagtgtttt tgatttcagc gtgaagggtt ttgattgttt tatctgataa 2630461 ttgatttgct tttgtctcgg gatggacacc cgctctgaaa agagcctcat ccacataaat 2630521 gttcccgagt ccaactaccg ttttttgatc cagtagggca gttttgacag cgcggtttgt 2630581 tttcgcaagc cggtctttta aatacgcact tgtaaattct tctgcatccg gctccggccc 2630641 taactgagaa agcgggagct cgcccgcttc ttctcccggt ttaaataagt gcatggttcc 2630701 aaatttccgc acatccctgt accggagctg ggttccatcc gtcatcgtga atatgacatg 2630761 cacgtgttta tcgtcaggct cctcggcttg atgaagaccg tattttcctt ccattcgaag 2630821 gtgagaaacc ataacataat gatctaaatg aaacagtaaa aactttcccc gtcttccgat 2630881 ggactgtatc gtttctcctg ctagttttcg cgcaaattcc tccggttcgg caggccgttt 2630941 gatgatattc ggccatctga tctctaccga tttgattgtt tttcccttta caagcccggt 2631001 cagagtgcgc cggaccgtct caacctctgg taattccggc acatccatca cttcctatct 2631061 ctgtttattt cgcatcgtac caagatgggc ctgatgcaaa gtccaccttt aacggcacat 2631121 ctaatgcaag cgcatgctcc atcacttcag gaacaagctt ttcaagaatt tcaatttctt 2631181 cctttggcgc ctcaaaaatc aattcatcgt gtacttgaag cagaagcctt gctttcaact 2631241 gtttttcttt cagcttggca gccatgtcaa tcatggcttt tttgataata tcagcggcgc 2631301 ttccttgaat cggcgtattc atggccgtcc gctccgcaaa acttcggata ttaaagttcc 2631361 ggctcgtcag ctcagggatg tagcggcggc gatgcataag cgttgttacg tatccttttt 2631421 gtttcgcttc ctgtactgaa tcttccatgt acgcttttac gccttggaag ctttccagat 2631481 agcggtcgat aaatgctccc gcttccttcc gggtaatgcc gaggttctgt gacagaccgt 2631541 aatcgctgat cccgtaaaca atgccaaagt tgaccgcttt cgcctggcgt ctcatcgcag 2631601 atgtcacttc atccttagcg acatggaaca catccattgc cgttttcgtg tgaatatcca 2631661 tatcattagt aaaagcttcg atcagatttt catcctttga aatatgggca agcacccgca 2631721 gctcgatttg tgaataatcg gctgcaaaaa tgagccagtc tttttcagac ggcacaaaag 2631781 cttggcgaat tttccgccct tcctcaagcc tgatcggaat gttttgcagg ttcggatcag 2631841 tcgagctgag acggccagtt tgcgttaagg cctggttaaa tcgcgtgtgc actttatgcg 2631901 aatccggtct cgtcaccttt aaaagccctt cgatatatgt tgattgaagc ttgccaattt 2631961 gtctgtactg taaaatatag tcgacaatat catgcttgtc agccagcttt tcaagcacat 2632021 cggcagacgt agaatagcct gttttcgttt tctttacgac aggaaggccg atcttttcaa 2632081 ataagatgac gcctagctgt ttcggagaat tgatgttaaa cggctctccc gcaatctcat 2632141 ggattttttc ttcatattcc ttcagcttcg cacccagttc ttcacccatc cgttttaaac 2632201 ggtcaacatc gaccttgacg ccagttgatt ccatttcgcc aagaataagc gcaagaggca 2632261 tttccagctc ttcaaacagt tcaagctggt cgttgttttc cagctcttga acgagctttt 2632321 cccgaaggct ttgaatcgct aacgcttttc ggccaaggtg ctcagacagt acgtcttctg 2632381 acggcactgc ccgttttgct ccttttccat aaactgattc atcacttgaa acgatatgca 2632441 ggccgtaatc cttagccaca ctcgcaacgt cgtcatatga attgcccggg ttgatgatat 2632501 aagccgcaag gagcgtatca aactcggctc ctttcagctc aatgccctgc cagcgcaaag 2632561 cgacaacggc ccgcttgctg tcgaagaccc atttcttctg ctcgtcattt tccacccatt 2632621 ctttaaacac ctcagactca acggcaatgt ctttcggaat gaaataagct cccgtttcat 2632681 ttacgatcga aaatccgagg atcggctctt catgataatt atcgccaatc tgttcaacga 2632741 caaatgcgga tggagaaacc aatatatcgc ttgtcacgtc tgtgactgtt ttgacattaa 2632801 tgtcttccaa cgattgatcc tgttctgctt ctgcactgtc ttctccaagc cgttcaagaa 2632861 gcgtgttgaa gccaagatct ttaaagatgg caatgacctg ttcacgatta aagccttgat 2632921 attccaggcc ggaaacagat acctcaatcg gagcatccgt cataattgtc gcaagctcct 2632981 tgctcatcaa tgcctgatcc ttaaactcct caagcttttc cttcaatttc tttccgctca 2633041 cctcgtcaat ggactccagc agcttttcaa cggaatcaaa ttgttttaaa agcttaatcg 2633101 cagtcttttc tccgacgccg ggcacacccg gaatattatc tgaggaatcg cccatcagac 2633161 ccttcatgtc aatgatttgt tcaggcgtaa gcccatattt ctctttgaca tgctccggtg 2633221 tgtaaaattc aacatcggta attccctttc tcgtaatggc aactgtcgtt ttgtccgttg 2633281 ccagctgggt taaatcctta tctcctgaga aaaccttaac ttcaaatccg tctttttcag 2633341 ccgatttggc cagtgtgccg ataatatcat ccgcttcata ttgttccagt tcatagcggc 2633401 tgatctggta ggcatccagc agctcgcgga taaacggcat ttgttcggaa agctcaggcg 2633461 gggttttctg tctgccgcct ttatattctt taaatgtgcc gtgacgaaat gttgttttcc 2633521 cggcatcaaa cgcaaccagc atgtgcgtcg gtttttcatc ctcaagcatt ttcatcaaaa 2633581 tcatcgcaaa gccgtataca gcattcgtat gaacaccttt atcattgctt aacagcggca 2633641 atgcaaaaaa cgcccggtaa gccagactgt ttccgtctac aagcactaat ttttttcgtt 2633701 ccgtcattca atttcctcct aagaagcctc aggcttccat tcatctctta catagtcatt 2633761 agctcctctt attttaacaa agttcaattt gaaaggaaaa tacgtgaact ataagagaag 2633821 acacaaaaaa ggacgggaac acaaataggt tcccgccgtc aaaattggct ccttggatga 2633881 aggggttcta ctacatccta ccagcatagg tttaacagtg catgaagata ttgttaaacc 2633941 tttgtaaaca ttaggcggac ttttcagcgg cccgtttcag cgtcacggta aagacagttc 2634001 cccgtccaag ctcgcttgtg acatcaattt tcccttcatg agcctctatt aaatgcttga 2634061 caatcgctag gcccagcccg gttccgcccg aatttctgct tctgtcttta tctacacggt 2634121 aaaagcgttc aaagatgcgc ggaatttctt ctttctgaat tccgattcca gaatcggcaa 2634181 cctcaatctg aatgtctttt tctctgggct ttacattgat agccacggag cccccctcag 2634241 gcgtgtaggt taatgcattg tttacgagat taagaaatac ctgtttcagc ctgtacgggt 2634301 caccagatac atattgaggg tctttcggga cattcaggtg caaggagatg cctttctcat 2634361 ccgccttatg cttcagaagc gtttcaatct caccaagcat tttggccggc tcaaacgttt 2634421 cgatactgag cgtgaaattt tgctgctcga tttttgagag atcgagcaaa tcctgaacca 2634481 aagactgaag cctttcgctt tccttaagaa taatagagag aaattcagaa agcgcctctt 2634541 tgtcttccat cgccccgtcc aataacgtct ccgtaaaccc ttttatggac gtaatcggtg 2634601 ttttcagctc atgagaaaca ttggccacaa aatccttcct catctgctct aatttcttcg 2634661 tttccgtcat gtcatggaaa acgagcacaa ttcctttcca ttcatcgtcc ggccccataa 2634721 tcggaacgcc gtccacttca aaataacgcc gttctatttt gatcggcagt cttaacagct 2634781 tgcatttctt tgtctccgtc ataaaaatgt cttcgacaag ctggatcact tcttcatgtt 2634841 caaatgcatc gtgataaaga cggcgcagca tatgattcgg attgatatga aactgcttgg 2634901 cgtaagacct gtttacgaga ttaataaagc ctcttccgtc gatcataatc agcccggagc 2634961 caatgttttc aatgactgtc agcagccgat cccgctgcat ttcctgcgtt cgcgtcattt 2635021 ccatcagatc aatggcaagg ctgttcatcg catgtcctag cttatcagaa cgcctaatat 2635081 agccgccgta cgtccgtgca tcgtagttgc ccttagagag ttctgtggct acatttgtcg 2635141 ctgactcaat tgacctttta taacgtgagg tcatgctgga ataaaaataa acaatgacga 2635201 taaatgcggt acaaagactg gccgtcagca tcccccacaa ttcgcctttt aagccgtcgc 2635261 ttttttcaga ggcggaaagc agcacatatc ctgttttttc accttcgctt ctaagtgaaa 2635321 gtccgtaata aagcttgtta tctgttgttg acagaatacc ctcatggcca gaaacaagcg 2635381 cctgcacctt ttgggaatca gccgatctac cgtttgaccc atacagcacc ttaccgtctg 2635441 tatcgataac ggatgcgctc acatcaagcg cgccgcctgc atctttaatg attttctcat 2635501 ttgcttgatt attcagattg ccggcatcaa gaagcgaagc caagtatttt gcttcttttt 2635561 caatgtgttc ctctgctttc ctttgatcag atgtttcaaa aagctgctgt aaaaacagcc 2635621 cgaggacaca aaacaccaga atcatacaga caacgaatac agaaaaaagg cgcacacggt 2635681 atttattcat tcatttttgg ctcctccagt ttatacccca atcccctaat cgttttaatg 2635741 tagatcggtt ttttggtatt gttttcaatt ttgtcgcgaa gatggctgat gtgcacatca 2635801 acaattctcg tatctccggc aaaatcataa ttccagactg cgctcagcag caggtctctt 2635861 gtcagaactc tgcctttatg tctgcctaaa tagagcagca gttcgaattc tttcggtgtc 2635921 agttcaagct gactttcttt aaagtacgct tcataatgat caggcaggat tttcagatcg 2635981 ccgattacga tctggccttc catttcatcg ttcttcatct cactagaggg cgcagctatt 2636041 tccgaacgcc ttaaaatcgc tttgactctc gcatttactt cccttggact gaacggcttg 2636101 gtcatataat catcagcacc gagctccagc cctaatactt tgtcgaattc ctcatccttc 2636161 gctgtcagca ttaaaatggg aaacatcagt ttttgctgtc tcagctgctt gcatacttcg 2636221 attccgtcca attttggaag catcacatca agcacaatca aatcaggttt ctctgtttcc 2636281 gcttttttga gtgcttcttc cccatccgag gcggtaatga catcatagcc tgaccgttcc 2636341 aaattgtact gtaaaagagt aacaatagat tcttcatcat ccacaactaa aattttcttg 2636401 ttcatgctgt gcctccagta ttataattcc ccgacatcct atttctctat tttatgtcat 2636461 cttaacatgt ttcatgattt tattttagcg aaagcaggac attccgacaa ttcgcctttt 2636521 acatcatttt taaaagaaat aaagacgttt atgatagcgc tttcatttat agtaaaaaga 2636581 gaaaggctgt attaagcaag cctttctctc tttttattag gataatactt tcatgacatt 2636641 tttgacagat tcaactgatt tattcagctg cgctctttca tagtctgtca gttcaagttc 2636701 aatgatttgc tcaagaccgt tgccgcctac aattgtagga acaccaaggt agatgccttc 2636761 atagccgtat tccccttcaa gataagcaat tgtaggaagg acgcggcgct gatctttcaa 2636821 gatcgcttcg accatttctg tcagagaagc cgcaggcgca taatacgcgc ttccgtttcc 2636881 aagaagattc acgatttcgc ctccgccttt tctagtgcgc tccacaattg cgtcaatccg 2636941 ttctttcgga ataagagttt caagcgggat accgccagca taagaataac gcacaagcgg 2637001 aaccatatcg tcaccgtgtc cgccgagtac gaaaccagtc acatctttca ctgacaggtt 2637061 taattcctct gccacaaatg ttctgaatct tgccgtatca agcacacctg actggccgat 2637121 tacacgctct ttagggaagc ctgattcttt gtacaccgcg tatgtcattg catcaacagg 2637181 atttgtcagc accacaataa tagagtcagg agaatatttc acgatttcct gcgtaacgct 2637241 tctcataatc ttttcgtttg tagagaccag atcatctctg ctcataccag gttttcttgc 2637301 gataccggct gtaatgacaa caatgtcaga gccggctgta tcctcgtaat tggatgttcc 2637361 cgtaattttt gcgtcaaagc cttgaaccgg gcttgcttca agcatatcaa gcgcttttcc 2637421 ctttgtcggg ttctccaatt gcggaatgtc aacaagaaca acgtctgcca gctctttttg 2637481 agcgattaaa aatgcagttg tagctccggt aaaacctgct ccgataacag aaactttttt 2637541 acgagtattt cccatgtctc tcttctcctt tatggctagt tttaggcttt ttccttgctt 2637601 agtccatgtt tttgatcagt tcttctccga actctgaaca tttcacttca gtcgccccgt 2637661 ccattaatct ggcaaaatcg taagttacga ctttagaagc gattgttttt tccatagatt 2637721 tgataaccaa atcagccgct tcgttccatc ctaaatgctc aagaagcaga acgcctgaaa 2637781 gaataactga agatgggttt actttatcaa ggcctgcata tttaggagcc gttccgtgcg 2637841 tcgcctcgaa aatcgcatgt cctgtttcgt agttgatgtt cgctccagga gcaatgccga 2637901 ttccgccgac ttgcgcagca agagcatcag aaatgtaatc tccgttcaag ttcattgtcg 2637961 caacgacatc aaactcgttt ggacgcgtta agatctgctg aaggaaaatg tcagcaatgc 2638021 tgtctttgat aatgattttt cctgctgctt ccgcttcgct ttgcgctttg ttggcagcgt 2638081 cttttccttg ttcttcagca atgcggtcat attgagccca tgtgaagact ttatctccgt 2638141 attctttttc agcaagttca tagccccagt ttttgaaggc gccttctgtg aacttcatga 2638201 tgtttccttt gtgaacaagt gttacagatt tgcggccatg ctcgatcgca taatcaatgg 2638261 cagctctgac caagcggctt gttccttctt ctgaaacagg cttaatgccg atacctgatg 2638321 tctcagggaa acggatttta ttgacgttta actcattttg aaggaagctg ataagctttt 2638381 gcacttcttc agagcctttt gcatactcga tgcctgcgta aatatcttct gtattttcac 2638441 ggaagatgac catatcagta tcttcagggc gttttaccgg tgacggcact ccagtaaagt 2638501 atcttacagg tcttaagcag acgaataggt caagctcttg tctgagcgct acgttcaaag 2638561 aacggatacc gccgccgaca ggtgtcgtta acgggccttt aatcgcgatg aaatattcgc 2638621 ggatcacatc taatgtttca gcagggagcc actcacctgt tttattataa gccttttctc 2638681 cggcgtaaac ttctttccat gtaattttct tttcgccttt gtatgctttt tctactgctg 2638741 cttccaaaac cttcgaagcc gcgttccaaa tatcaggacc ggttccgtct ccttcgataa 2638801 atgggataat cgggttgttt ggtacgttta atactccgtt agagactgta attttttcac 2638861 cttgtgccac aataaaaacc tcccagtatg taattcatat ttagaaaaca ttttattttt 2638921 cttatataga aaataaaatg atttttccta acattcaatt taaagtgtaa cccaattttg 2638981 atgtctgaac aagaggctaa cctcattgac gcaagccagc ctccaatggt tctttaggct 2639041 ctttcttcaa tcggaacgaa tttttgtttg tcagggcctg tgtaatctgc ccgcgggcgg 2639101 atcagacggt tgttgtcata ctgctcaaga atatgagcga gccagccgga cattctgctt 2639161 acagcaaaaa tcggtgtaaa caaatcatgg tcaataccga ggctgtgata tacagaagcc 2639221 gaatagaaat caacgttagg cggaagcttt ttctctgatg tgacgatgtc ttctatacga 2639281 atcgacatct cataccattt gctttcgcct gtcaggttgg tcaggcgctt gctcatttct 2639341 ttcagatgct tcgcgcgcgg atcaccatgc ttatacacac ggtggccgaa tcccatgatt 2639401 ttttctttct tttcaagttt agcgcggatg tacggctcag cgttttccac ttcaccgatt 2639461 tctgtcagca ttttcataac gccttcattc gctccgccgt gaagaggccc tttcagcgcg 2639521 ccgattgctg cagtaatgcc tgaatagatg tcagaaagtg ttgcgacgca gaccctcgct 2639581 gtgaacgttg acgcgttcag ctcatggtca gcatgtaaaa tcaatgcttt gttgaaggct 2639641 tcaacttcaa ttggtgaagg ctcttcaccg tttaatgtgt aaagaaaatt ctccgcaata 2639701 ccgtaatctt ctctcggttc aacaggctca agacccttgc gaattctgga aaacgctgca 2639761 accaggccag gcacctttgc ctgaaggcgg atcgcctttc tgtagttggc ttccgggttc 2639821 atggtatcag cctcgctgtc aagcaggcct agtaatgaaa ttgctgtccg aagagcagcc 2639881 atgggatgaa cattttcgag ggaataagat ttgaagtgct caataatttc ttgcggaacg 2639941 gcagcttcct ttgcaagctg ctgctttaac tcttcaagct cttttttgtt tggcagcctt 2640001 agatgccaaa gcaagtagat gatttcttca aaacttgcat tctctgtcaa atcatcgata 2640061 tcatacccca catatgtaag ggtatcatca ataatagaac taacagatga tgttgttgct 2640121 acaacccctt caagaccgcg tgtcgctgtc atatataaca tctccttttc aataaatttc 2640181 ccctttaaga gtgttgtaaa aacatgaggc ttacttaaaa agcacgatgc aagtatttct 2640241 ctcccccaaa aagaaaatgc ttacatttta ctggctgctg gaactaaaac cctttgcttt 2640301 tgaaagaaca taacaaattt ttataagctt atttaagttt aagcctattc tcattataaa 2640361 caataatcag acatttgtta aatgtttacc tataattttt tttttccatt ctgtgatttc 2640421 cccgaaaaaa cgcctttatt tgcgggtttt tgcataaaaa aaagcggctt taaggccgct 2640481 tttttttatg aagtgaacag ttttacgatc tgcatggcta aataagcaat ccccgctccg 2640541 atcagcggcc ccaccgcaac tcctccaaaa agcgcgactg caagaatggt cccgatcacg 2640601 agagcagttg taatatgcgg atcattttca agcagggtca ggccgttttt tgcaatcagc 2640661 gccactgcga tccccgctcc aagggcgatc catgcgtagg aagaccgcat tgcttctcca 2640721 agctgcttaa atccgatttc tcccgtggca atcgggacaa gaacggcgat ggtaataatg 2640781 gtcacacccc agttaatgcc ttttgactgg atggtcggaa ataatttctg atcaagccca 2640841 acgattttga tgatcaaaag gacggataca gcaaagagca atgattggtt ttttgcgata 2640901 agtgcgatag ccaagagtaa aattaaaaat aaattcgctt gtgtaaacac atgccatccc 2640961 tcctttaaga tgaatgtatt catattcagc cgcagcgtga atacatataa aaaataggac 2641021 atgctgacga gaggaggacc gtttttgtga atcaatctta tatcactatt tttttcagaa 2641081 ccctctttgt catatcaatg accgcagggt cgatagctgc ggcctattat tcgtttccgt 2641141 taacttatcc gttcctgatc gcccttattc tatcttcagt gattcatcct gttgtcgatt 2641201 atttggacaa agtgacagga ttcccccgaa cgataaatgt tctgggcgtt cttgcttttt 2641261 ttctgctcgc agccttcggc gtgctcacca ttctggtagc cgaaatcgta acgggaacag 2641321 cctatctagc aaaaacgctg cctccgcata tcagcacgtt tatttcatat tgcgaaaaat 2641381 tgtttaccac tcatattcag ccgctctata acgagttaac tcttttgttt caagaattgg 2641441 aaacgaacca gcaggcttcc atcgtcactc atatccagac actcggtgat tctgccgcta 2641501 aaaatgccgg gctcctgctg tcccacattc tagagatgat cccgagattt ttcgctcttc 2641561 ttcccaatac ggcggcggtt ctgatttttt ctcttctggc aacctttttt atgacaaagg 2641621 attggcataa gctgaaagcc atgcttgttt taattctgcc ggatcgtgtg acagctaaca 2641681 gcaaagcaat cagcagcgaa ttaaaaaaag caatgactgg ttttatcaaa gcacaagccg 2641741 tcctcgtttt catcacgatg gtgattgtat ttatcggcct ttctctctta aaggttgaac 2641801 acgccgcaac aattgctttt ttaatcgggc ttgtagatct tctcccttac ttaggtgccg 2641861 gctccgtatt tgtgccctgg attttgtatt tatcgattac gggccagctg ccccaagcaa 2641921 tcggaattgg tatcctgtac ctcgtcgttc ttattcagcg gcagctgaca gagcccaaga 2641981 tactaagtaa atctatcggg atcgatccgc tggcaacact catcgccctg tttgccggct 2642041 ttaaattatt cgggttttta ggactgattg cgggaccggc tgtactcgtc atcatccaag 2642101 ctttcatcac aacaggcgca ttaaaagaaa tatggtccta tatcaccgtt cagcaaaaat 2642161 aaaacggcag ccgttttttc atggctgccg ttttttattt gatgatgatc cgcttattct 2642221 tcgacattcc tctcagccat ttgaacagaa tcggcttaca ccagccgcgg gtaaacggga 2642281 taagaagaca ggcgccggcc aaatctgata aaaagcccgg aagcatcagc aatagaccgc 2642341 caatgaaaat gcacagaccg tcagcaatcg cttctcccgg cattttgcca tattgaagat 2642401 cacgctgaac cttataatac acttcggttc cttgtttttt tgcagctgct gcgccgataa 2642461 tgccagtcag aatcatgaat agaactgtcg gcaaaatacc aatcagattt cctaaaaata 2642521 ggaatatacc gatttctatt gccggaaaca caataaaaag caaaaacaaa aatctcatat 2642581 ccaagccccc cacacgtgta acacgttctg ttcaacaaaa ggcatgataa agagaaaagg 2642641 aagggattcc ccttccattt tcacctgtaa ttaaagaacg ctcgcacggc cttgatagac 2642701 tgcgcctctg gaagcgtcaa ctgtaatatc ctggccatct gtcaaaatag atgtcgcatt 2642761 ttccagaccc acgataaccg ggatgccaag gcttaatccg actaccgcag catggctagt 2642821 caaaccgcct tcttctgtaa taagagcaga cgctttttca agggatgcaa tcatatcacg 2642881 gtcagtgctt ttggtaacaa gtaccgcacc gtcagtcatt ttttgctcag cttcttttgc 2642941 attttgtgca acgacaaccg gaccgtaagc tgatttgcgt ccaatgcctt ggcctttagc 2643001 gatgatatcg ccgacagtat gaaccttcat taagttcgta gtgccggact caccgacagt 2643061 gccagctgta ataacgataa gatcgccgtg ttttacaatt ccgctgttca atgatttttg 2643121 gacagcatcc tcaagcatct catctgttga gctcgcattt tggccgcttt ccgcgaatac 2643181 gccagatacg agggcaagct ttctggaaat agagtcattt acagtaaccg caacaatcgg 2643241 agcctgcgga cggtattttg caatcatacg tgctgtatgg ccgctttctg tcggcgttac 2643301 gatcgcagca gcattcaggt taatcgccgt atgtgcgaca gattgtccaa ttgcgtctgt 2643361 aattgtcatg cccacttggt ctctgcgttt tgagagaatt tctttataat ttaatgcttc 2643421 ttcagaacgg gacgcgatgt tatgcattgt ttgaactgct tcaaccgggt aacttccggc 2643481 agcagtttca ccagaaagca tgatcgcatc tgttccgtcg aagatcgcgt ttgcaacgtc 2643541 acttgcttcc gcacgagtcg gacgcgggtt gcgctgcatg ctgtcaagca tttgtgtcgc 2643601 tgtaataaca ggtttgccca gcgcgttgca ttttttgatc agttcttttt gcacaagcgg 2643661 cacttcttca gctggaattt ccacacctaa gtctccgcgt gcaaccatta agccgtcaga 2643721 cacttcgaga atcgcatcga tgttgtcaac gccctcttgg ttttcgattt tagggatgat 2643781 ttgaatatcc tgagcgttgt gctcttcaag aagctcacgg atttcgagca catccgtaga 2643841 acgtcgaatg aaagatggtg cgatgaagtc tactccttgc tcaataccga aaacgatgtc 2643901 tcgcgcatcc ttttcagtaa tccccggaag attgacactt acgcccggta cgttaacacc 2643961 ttttttattt ttgagtgttc cgttgtttaa tacttttgtt ttgatttcgc gtttagcggc 2644021 atctacatca agtacctcaa gaccgataag gccgtcatct aacagaatcg ttgaaccttg 2644081 ttcaacgtca tggactaaac cttcatatgt cactgaaatt ttatctgttg ttcctacaac 2644141 ctcgtccatt gaaataatga gctctttgcc tgtttcaagc tcaataccgc cgttttccat 2644201 tgtatgtgtg cggatttcag gaccttttgt atcaagcaga attccaacgt tcttgccaag 2644261 ttttttactt gcttcgcgga tatttttaat tcttgcaccg tgctcctcaa aatctccgtg 2644321 agaaaagttt aatcgagcca cgttcattcc tgactccatt aatttcgtaa gcatttcaat 2644381 actttcactt gccggaccga tggtacaaac aattttagtt tttctcattt ggttcacttc 2644441 cttctgaaat cttcagcctt cagctgtaca ttagatagac agttcttttg aaagctgata 2644501 catgttttgc tcaactgtgt gttttgtctc aagtatttct ataatatcat ggtctacaag 2644561 cttattgttt tgtataccta cacagcgtcc gccttttcct tcaagcagca gttcaactgc 2644621 atatgcgccg agacggcttg ccaacacacg gtcagcagca ctcggagaac ctccgcgctg 2644681 gatatggccc aatacagata ccctagtttc aagatttgtt tcttcttcaa tgcgtttccc 2644741 gaattcaaca ccgctgccta caccttcggc aacaataata atactgtgct tcttgccgcg 2644801 ttcgtggccg cgttttaagc gggcaatgat ttcgtgcatg tcatagtctg cctcagggat 2644861 taagatcgat tctgcgcccc ctgcaagacc ggcccacaat gcgatatcgc cggcatgacg 2644921 gcccattact tcgattacat atgtacgttc atgagaagtc gctgtatcgc gaatcttatc 2644981 aattgcgtca attactgtat ttaaagctgt atcgaaaccg attgtaaaat cagtgcccgg 2645041 aatgtcatta tcaattgtac ccggtacacc tacacatgga aacccgtgtt ccgttaattt 2645101 tttcgcaccc atataggaac cgtctccacc gataacaaca aggccttcaa taccaagctt 2645161 cttcaagttt gctatccctt tttcacggcc ttcaactgtt ttgaattcag gacatctcgc 2645221 cgtataaagc ttagtccctc cacgatgtat aatatcgcct actgatccga gttcaagctt 2645281 ttcaatcttt ccgctgatca atcccgcgta tccgttgtaa ataccgtaaa cttcaacgtc 2645341 atgatagatc gcttttctga ctactgcgcg aactgctgcg ttcattcccg gggaatcccc 2645401 gccgctcgtt aataccccta ttcgtttcat tctccattca cctcagcaac atatatgatt 2645461 aaacataaca tgatcattgc cctaaaaaca atgaaaaggg atctccatcc tccctatgaa 2645521 accttaccta ttatacaatt aaataaattg tttttaaata aaatttaagg aatgtcacaa 2645581 aaaataaacg tgagccaaag gcttcacgtt tatttagttt accccgatat attgatcttc 2645641 aaccgagact ttgccaattg ctttatattt ttcataacgc tgctgaacta attcttcttc 2645701 gctcagcttc agtaaagttt ttaacgattg tttaagggtt tcgtccatat agcttgcctg 2645761 cagcttcaca tcatggtgcg ctccgccttt tacttcttta atcatatgat ctataatacc 2645821 taattctttt aaatccggcg cagtgatttt cattgtttct gctgcttttt tagcaagact 2645881 ggagtccttc cataaaagtg ccgcggcacc ttccggagaa ataacagaat aagtagagtt 2645941 ttccagcata tgcaagtgat tgcctacacc cagaccaagg gctccgccgc ttccgccttc 2646001 accaatgacg atgcagataa caggcactcg aaggccggcc atctcaaaca ggtttttggc 2646061 aatagcttca ctttgtcctc tttcttcagc tgctcgtcca gggtatgccc ccttcgtatc 2646121 aataaaacag ataattggtc tgttaaattt gtcagcctgt ttcatcagac gaagcgcttt 2646181 tctgtagcct tctggatgcg gcatcccaaa attgcggact aggttttcct tcgtgtcttt 2646241 gccgcgctga tgcccgatta ccgttacagg gaggccgtgg aacttcgcaa tcccgccgac 2646301 aatggcttca tcgtccccgt acgctctgtc tccgtgacat tcaaaaaagt cggtaaacag 2646361 gtgttcgata taatcaagag ttgtcggacg gtccgccaga cgcgcgattt gaacccggtc 2646421 ccacggcttc aaatttttgt aaatatcatc ctgaagctta gcgagacggt cttcgagccg 2646481 ttcgatttcc gcacttagat ccatatcgga atcttgggtg aattttttta gttcggcgat 2646541 tttggtttgc agttcaatca ccggtttttc aaattctaat cttggagcca ctcaatgtca 2646601 cctcctgttt gatgcatatc cagcagattt tctaacgttt ttttcatatc gtcgcgatga 2646661 ataaccgcat caagctgtcc atgttttaat aaaaactcag ccgtttggaa gtcctcaggc 2646721 agtttttctc ctattgtctg ttcaataatc cgtcttccgg caaaaccgat cagcgcgcca 2646781 ggctcagcga aattgtaatc gccaagggat gcaaagcttg ctgatacgcc cccggtagtc 2646841 ggatgcgtca ttactgaaat aataagaccc tgttcttcac tgaacagttt taacgcagag 2646901 cttgtctttg ccatctgcat caaacttaat acgccttcct gcattctagc accgcctgaa 2646961 gccgtaaaaa taataaacgg aactttatca gcttttgctt tttcaatcgc aagcgtgatt 2647021 ttttcaccga cgactgaacc catgctgccc attctgaatg aagagtccat gacggcgaca 2647081 acagccgggt gtccgccgat ggtgcccttg cctgtcacaa cagcctcgtt taaggatgtt 2647141 ttctcgcgat ctttttcaag cttttccaga tatcccggga aaccaagcgg attttccgag 2647201 agcattccct gattaaattc ctcaaaggat tgttcatcca tcaagctttc gatacgctgt 2647261 tttgcgttca ttgggaaatg ataatcgcag ttcatgcata cccgcatatt tttatccaac 2647321 tctttagtga gcatgatttt tttacactta ggacattttg tcataatgcc ttccggaaca 2647381 tcgtgcttcg cttgatcaga cggtacggaa gcatactttt tctttttcgt gaatatatcc 2647441 tttaacaaat gattacctcc cttttgtgaa gggttctctt caccgcatgt catcaaacag 2647501 atagacttgc taataacttt accgaaacta ttgtactttt tttgtcaaac gctgtcatcc 2647561 tcaattcgac aactttttat tcgatgacgt gctcggaaag gcttgtatga aatcagataa 2647621 ggtgttgaaa cgacaaggtt gacagcgcat tcaaaaataa tgttaaaccc ggctgaaatt 2647681 tttttaaggc taacccccta aaaaaatttc agccgtcagt ttaacttgag aacagcgcgc 2647741 cggtctccgc caacgcgctg ccatttttgg aatgaattaa aattattcac caataatcgt 2647801 aagttttctt gttttttctg cgacttcctc agggtcaaca gtgattcttg caacacctgt 2647861 ttccatcgca gcttttgcca cagccttcgc aacagcaggc gcaacacgtt tatcaaacgg 2647921 tgcagggatg acatagtctg cgctaagctc atcttctgaa accagtgaag caatggcttc 2647981 aaccgctgcg attttcattt cctcgttaat atgagtggca cgcacatcaa gcgctccgcg 2648041 gaaaatacca gggaatgcaa gaacattgtt tacttggttc gggaagtcag aacggccagt 2648101 tccgacaacg cttgctccgg cttcacgcgc atcttccggc atgatttccg gatttggatt 2648161 tgccattgca aagataatcg gatcttttgc catgctttga accatttctt ttgttaacgc 2648221 gcctgctaca gagacaccga taaatacgtc agcatcaacg ataacatctt tcagagaacc 2648281 gtctttgcga tcttggttcg tgaacttcgc cacttcattt ttgacatcgt tcatgccgtt 2648341 cgggcgccct tcataaatgg cccctttgga atcgcacatc acaatgtcgc gaacgccata 2648401 atgatgaaga agcttgataa tcgcaatgcc agccgcaccc gcgccgtttg cgacaacttt 2648461 aatggatgac atggattttc cagacagttt cagcgcgttc acaagacctg ctacggttac 2648521 aatggcagta ccgtgctgat catcatggaa aaccgggatg tttgtttctt ttttgaggcg 2648581 ctcttcaatg ataaagcagt ttggcgctgc aatatcttca aggttgacgc cgccaaatgt 2648641 cggttccagc aattttacag tttcaacgat tttatcaaca tcgtttgtgt ttaaagcaat 2648701 cgggaacgca tctacgcccg caaagctttt gaaaagaact gctttccctt ccataacagg 2648761 aagcgccgct tcagggccga tgtttccaag gccaagcaca gctgtaccgt cagttacaac 2648821 tgctaccatg ttccccttca ttgtataatc atatactttg ttaatgtctt catgaatatc 2648881 cttacacggt tctgcaacac ccggagaata cgcgaggctt aaatctttcg catttctgac 2648941 ctctactttt gatttagact ccagtttccc ctggttgact ttatgcaggt gtaatgcttc 2649001 ttctcttaat gacattctcc taaacactcc ttatggatat tttttgattc gtatactgct 2649061 gcgttgattg ctgcattctg cggagtaaat ctatctgaat atttaaacag gatcacataa 2649121 ttgctccaat tgtataacaa aaagcgaatc gttaccactg ttttaaaacg acgttttttt 2649181 gacccaacag ctcttttaag cgatataaca cctggtgatc tgcattgata tggaacgact 2649241 caggtagctt aatcgtctgt ttttgccttt cataatagag ataaacgcct gtttcccctt 2649301 tatgctccag caaaatgcgc ttaatctttg ccaggatctc ctggctgtgc tgactgcttt 2649361 ctatttttat ataaaccgat ggcgcttttt ctgcatccat atcttctaat aattctgccc 2649421 gggacatgat gaattggatc ttatcttgtc taacttcaca tttccccgca gtgaacaaaa 2649481 gagcgccttc tcttaaaacg ggagaaagct gtctgaattg ttcagggaag actacggctt 2649541 ccatctcgcc ggtttcatca ctgagcgtta aaaacgccat gttttgacct gttttcgtcc 2649601 gaatcgtttt gatcttcgac agcagaacgc ctagtgaaag ctgccttttg actgcccgct 2649661 gagcctgcag aatggagact gctccttgcg cagtgagctg ttttcggaag gcggagaggg 2649721 gatgatttga aaaataaatg ccaagcgttt ccttttcaaa cgcaagtaaa tccaccagag 2649781 gaagctcctc cgtctccaca tacttcggct taattgaaaa cgattcatct aaaaacaatc 2649841 ccatttggtc atcgtccgcg gcgaatagct cagcatgttc caaagcaaca tcaatggatg 2649901 cgagcagcgt ggcccggttt tggccgaatt cgtccatcgc accagaaaag ataagtgctt 2649961 caagcatttt gcgatttacg ctttttgacg gcacgcgaaa gcagaaatcg aaaagatctt 2650021 caaatggttt ctcttttctt gctttatata tatctttgac tgctgagacg cctacacttt 2650081 ttatcgcgcg gaggctgtat ctgacagatc cgttttcaac tgtaaacgga aaactgcttt 2650141 tattcactga cggaggaagg atacgaatcc cgctcccctt tgcttcgtaa agatattgag 2650201 agattttatc ctcattgcca atgacgcttg tcagcaatcc gcacataaaa tataacggat 2650261 aatgagcttt caaatacgca agctggcacc cgatcatgct gtatgccacc gcatggcttc 2650321 tgttaaagcc atagtttgcg aatttgacga ttaaatcgta gacctcattt gcagtgtcta 2650381 cagaatactc cttttttaag cacccttcaa caaaatggct tcgctctctg tccaggattt 2650441 cttttttctt tttgctgacc gcccttctca ataggtccgc ttcgcctaaa gaaaaccccg 2650501 ccatacggga agcaatcatc ataatttgtt cctgatacac aatgacgcca tatgtatctt 2650561 ccaaaatgct ccttaaatct tcatgaggat agtgaacagg cgcccgaccg tgtttacggt 2650621 cgataaataa cggaatattt tccatcggac ccggccggta cagtgcattg accgccacaa 2650681 tatcttctag gcccgaaggt ttcagccgtt tcaagacgct tctcatccct gcagattcaa 2650741 gctggaaaat gcctgtcgta tccccttttg acagcaagga gaacgttttg tcatcgctgt 2650801 aggaaatact tgaaaggtct attttaatat tttcttcttt ttcaatcatt gaagtgatgg 2650861 attcaataag tgtcagattc ctcaaaccta agaaatccat ttttaaaagg cccaagtctt 2650921 caagatggtc catcgcgtat tgcgttaaat agatcccttc atgcccttct tgaagcggaa 2650981 caacatctgt taacggttct tcactcagga caacgcccgc tgcgtgggtt gatgcatgcc 2651041 ttggcagccc ttctattttc cgggcaattg aatagacttg ctgaagcagg cttgactccc 2651101 gaagccgctt atccagctgc ggtgactgct gtctcgcttc atccagcgtc attcccggtc 2651161 ttgaaggaat gagttttgca agctgatctg cctccttcgg gctgacgccg aatactctgc 2651221 cgacgtcccg gagcgccgcc tttgccgcaa gtgttccaaa ggtgataatc tgtgcgacgt 2651281 gcattgcacc gtatttctgc tgaacatatt gaatgacttc atcccttcta gtatcgggaa 2651341 agtcaatatc aatatccggc atgctgacgc gttcgggatt taaaaatctt tcaaacagaa 2651401 ggtgatgctt aatcgggtca acatctgtga tatacagcac atatgccaca agagaacccg 2651461 ccgcagaacc ccttcccggt cctgtaacaa tccctttttc atgggcgtgc ttcataaaat 2651521 cccacacgat cagaaagtaa tcgctgaact tcatccgctt gatgacatca agctcatatt 2651581 gaagacggcg aaggtatcgt tcatcaggct tgccgaaacg gctgcggagt ccctccatac 2651641 agatatccgt taaataatca tcagcggacg ttccgtctgg ggtcggaaaa gacggtagac 2651701 gggtctgccc gagactgacg tcaacccggc attgttccgc gatctctaca gaagcttgca 2651761 gtgcctcggg atgctctcga taaatgtttt gcatttcttc gagtggtttc aaatcgagat 2651821 caggcaaatc ttcagcgggt gcatccgtca gtttttcccc cgctttaatc gctttcaaac 2651881 aacggtaggc agccttatct tccttcctta tgtaatgcac atcgcctgtg gccgtaacag 2651941 ggatacccgt ttcttctgac agctttagaa tctgctcaga caagacttga ttccctttaa 2652001 aaggctgata ggagaaataa aaagctccct ttccgaatat agactgaaat tccagcgagg 2652061 cttgagcagc ctgttcgaac agccctcctt caagaagcgt ttcaatatat cctttttcgc 2652121 cgggcgttat tgcgataatc ccttctcgat aactgtgaag ccatttcggc ttcagtccgc 2652181 cttttgattt agattgcaga acgctgctga ttttcagcag gttttgatag cctgtattcg 2652241 attttgccag caggacgagc gggtatgctt caagctcgct gtcatctgta aaaacagaag 2652301 ccgtcaaacc gattattggg ttgatccctc tcgccttgca agctttataa aattgaatag 2652361 ctccgtacat gacatgatca tctgtcagcg ccaaagacgc atatccgagc ctgtcagctt 2652421 cactgacgag ttcttccaca gccgcggcgc tgtttagcag gctatacccg ctatgcactt 2652481 gcaggtgaac aaaagacatg ctatcacctc tttctcatta cgatccattt cttccttcat 2652541 tataaggccg gtttccaaaa gaaacaaatg ttcttttttg actcatcatc atacttgtcc 2652601 tgaaagctca atatgatata aaaggtgagg tgataaagat ggatcaggaa gcaggattta 2652661 tggtgaattt tatcaatagc tacttcattg cgttaggggt gctgatcggg ggcgcactca 2652721 tcggagggct cggagcatac ttggcaggcg aacccccgct tacagccatt acaaagcttg 2652781 ccaaccggtt aaaaatatgg gcgcttgtcg cagctatcgg aggcaccttt gatgcggtat 2652841 acagctttga acgcggcata ctcgaaggca atacgagaga tatctttaaa cagcttcttt 2652901 taattatttc ggccatgggg ggcgcgcaaa gcggctggct tattatatca tggctgaccc 2652961 aggagcatct ttcttcatga gggtccccca gcattacaaa aaaccgggat ggcagcgttt 2653021 tttcgcggga atgatgtgcg gagccgtaat cagctggttc tttttcctgt ttacttacgg 2653081 aacattccaa gaggagcagg tcagcctcat cgaaaagcaa aaagagcatg taaaagactt 2653141 gaacaatcaa atttcgatct atcaggaaga cctccataaa ctgaatgaag ataataaaag 2653201 aaaactgctg attcaaagcg tcagcgtcaa attgctgaat ggggataaat ataaaatatc 2653261 acagccggat aaaacgaaat tcgaggagca tgtaaaggat gatatttcag aggtgattac 2653321 aaaagacata gagagcgtct atcaaacaaa ggatctcttg aagcggacaa ttgaaaataa 2653381 agtctatatg atcaatgaaa aaaaatacga ggcaaccgtc agagaattga ttatttatac 2653441 gaggctgaca gtggaacttg aaatttcttt cgccacataa ttatggattt tttttaaatt 2653501 ctccaaactt ctgtcgcttt ttcccattct tttttataaa ctatatgtga ggcttaatgg 2653561 cgaaaggaag gaggaaggga aatggaggtt tacagtgacc gtcagttagc aaaagatcaa 2653621 gcagcccgtc tcagacaagg tttttctgca tatgccgaaa caaactcact cgcttccctc 2653681 atcaaaaaag aacttcaatc acacaatctc caagtctacg aggaccttac tgatttcggc 2653741 tgctggttca tccccgtcac agatgaacac taagagagag ggtctcccct ctactcgtgt 2653801 tctttacata atgtttccag atcagctaaa atacgatcag cttcatccca gctgtaaata 2653861 gaggcgcctg aagctaacgg atgccctccg ccgttatatt tccgggcaag tccgttaatg 2653921 acaggcccct tcgaacggaa tctgactctg atttgatcgt cttcttctac gaaaaacacc 2653981 caggcgcgaa tacctgagat attgccaagc gtcccgacaa gctgcgacgc ttcagaagcc 2654041 gttgtgccga atttttcaag cgtatccttt ttgatgaaaa cagaagccgc cccgttttcg 2654101 gacaaagaca cattttgaaa gataaagccg ttaagcttca ccacattcag ttttgtttca 2654161 tacaattgat taaataactc tgaggaagag aatggatact gaatgagctc gcctgcatat 2654221 tttagtgttt tttccgtggt attcggaaat aaaaagcgtc cggtatctcc aacaatgccg 2654281 gcgtagatca gctctgccgc tttcgtattc agcttccagc cgtgctcttt tccttctaaa 2654341 tacagctcgt aaatcatttc acttactgag ctggcgcttg tatcgaccca gagaaggtca 2654401 ccgtatggat cttcgttcgg atggtggtcg attttcatta gtttggcgcc tgaaggataa 2654461 cgctgatcgt cgattctttc ctgatttgcc gtatcgcaga caatgacaag tgcgccttca 2654521 tatgtttcat tgtccacctc atcaagggaa tataagaaag agagggacgg ttcaggcgtg 2654581 ccgaccgcaa aaatattttt ttcaggatat gtttcacgca ggatttccgt aagcccacac 2654641 tgtgatccgt aggcatccgg atcaggacgc acatgtctat gtaagataat cgtgtcatat 2654701 aatgatatgg ttctgatcaa ttctgttttc atttgatact cctttattgt ttttattcat 2654761 taaatcacat tctctgccga cggaaaagaa aaataacgtc aaaaccaagc ccgtttttgt 2654821 ataaaatggg gttgtaaact tttacgatgg aggatttcat ttatgctggt tcttgttttt 2654881 ttgattgggc tttcagcctg cttttatgtg tactataaag taaaaggcgt acgggcaaag 2654941 ccatctttgg caaaagaaat atgttcagca aaatcaagca tggccttagg gtcactagtc 2655001 ctgttctacg ggcttaacca aatgatatta ttccattcag tattaacgtt agtaatcggc 2655061 ggtatcttta tcgtcatagg agcaggaagc gcttgggcag gttataaagc cttcaggcat 2655121 tacaatcccc ttcacgccaa agaagctgaa agagatcacg cgtaaggggc gcctgaacgt 2655181 cccttagctt ctttccatca gctgaaccat cagcatcgct ttagacacga tatgaccttg 2655241 gctgtgcact tccacttcca ttttcccaaa ctttctgccg gcctccaaga tgcgaggttt 2655301 gacttcgatg actgattcca tctgcacagg cttcaaaaag aagatggtga tgctctctat 2655361 gacgagttcg ccgcgttttt tcgagcgcaa aaatcggttt gccgcttgcg tcaaaatggt 2655421 cgtaaatacg ccataagaaa tggttccaag ctgatttgtc atttgcggcg tgacttcata 2655481 ctcgtaaacc gtttgatctt ctttatcatc accctcatct ttaaaccccc ttgaaacgat 2655541 atcatcaagc ttctccccga cctgcggctg cttttgaatc atttgaagag ctttcaatac 2655601 gtcttggcgg ctgatcatgc cgatgagttt ttggtggccg tcagtgacgg gaagcacttc 2655661 gatcccttcc cataccatca tttgcgcagc tgaagcgaca gatgttttcc caataaccgt 2655721 gacgggattt ttggtcatga ctttttctat agatgcattt cggtcatggc cagcaatatc 2655781 ttttgatgtc agaatgccat ggattttcat ttgatcgtcg acaaccggga agcggccgtg 2655841 ccccgtttca aaatttttct cataccattt ttcaagttta tccttaggcg aaagatatac 2655901 cgtgcggtca gcaggtgtta ggatgtcctc caccaaaaca atttcttttt tgatcagctg 2655961 gtcatatatt gcccggttaa tcatcgcggc aactgtaaag gtgtcatagc tcgtggataa 2656021 aatcggcagt tcaagctcat ctgccagctg cacaatgctg tcatccgtgt taaagccccc 2656081 ggtcaccaat acggccgcgc ccgcttcaag cgcctgcctg tgtgcattga ttctgtttcc 2656141 gacaatcaaa agattccccg ctgcggtgta acgcatcatc gcgtcaagct ccatcgcgcc 2656201 gatgacgaat ttattcaatg tcttatggag ccctgccctg cctccgagca cttgtccgtc 2656261 tataacattt acaacctctg cataggtaag cttttcaatg ttctcttttt tcttttgttc 2656321 aattctgatt gtgcccacac gttcaatcgt gctgacaaac cctttattct ctgcttcctt 2656381 gatcgctctg tacgcggttc cttcgcttac tttcatttcc tttgcaattc ttcggacaga 2656441 aattttttca ccgacaggca gtgaatcgat atacgttaaa atttgttcat gcttcgttgc 2656501 caagcctttc acctctaagg acagtcttct tgtttttatt ataaggtttc aaaggattta 2656561 tacgcaatga ggctggaaaa taaaaaagaa gcccgaccgg cttcttacag cgttgatttc 2656621 gttccagtca aacgcaagga ccacgtgatt ccttttacat cgtaaagcgg aaaaaccttt 2656681 atttttcttt taaatggaca tcaaccgctg tcttaacaat atttcgattc cctattttag 2656741 ataaaacaaa taaaactgcg gatagccata tcgcccctat ggccgtatag atcaatggat 2656801 gaacagctgt gtttgcgatc cattcattta ttaatgttct ggcatttacc agaataataa 2656861 atcctcctac aagcacaccc atcaattgcg gatgaaactt ctgcaccagc catgctgcga 2656921 taggggcagc gataattccg ccggccatta gtgaaaacac ccataaccaa ttgacgtcct 2656981 cccatcctaa tgaaataaga aaaccggcgg ttgcagatac ggcgatggca aattcacttg 2657041 tgtctacagt cccgacaact ttcctcgggc tcaagccttt gcgggataat aaaatcggag 2657101 tggtcaccgg tccccagccg cctccgcctg tggcatctgc aaaaccagcg atcactccca 2657161 atgggatgga ttgttttcgg tttaacggca catgcttctt ctcaagagcc ggcttatatt 2657221 gaaataaaaa cctgatcaat acatatccgc ccagaaggag caaaaacaaa gaaatatagg 2657281 gtttcgccac atctccaggt aattggctga ggaatgccgc gcctaaaaaa gcgcctatag 2657341 agccgggaat gacaagctga taaacggttt gtttgtcaac attgccaaat ttaatatgcg 2657401 acactcccga tgcggcagtc gttacgactt ccgctaaatg gacagaagcc gaagccacag 2657461 caggtgtgat gccaaacgcc aataacaaag aagttgaggt aaccccataa gccataccta 2657521 acgaaccgtc tattaactgc gacaataaac caataaatgc aaaaacgatt aatttcttca 2657581 tcagaacacc ccatctatat caatcagata tttttgactc ttcattcgaa tctaacaatc 2657641 tcttggcgct ttcatataaa aaataagagg ctttgataat tgcagtttca tctattgtaa 2657701 atgcagggtg gtgccaatca tgatcaccgt ctgttccaaa aaacgcaaag gatcccggaa 2657761 tatgctcaag ataataagca aaatcttccc ccgcggttga tggggcggga tcaatgactt 2657821 gaagtttcgc tttatgtgca gcgtctcgca ccagccccgt aattgcctca tcattacaaa 2657881 gcggcggcgg tccggaatgc cacttcacat ttgcctttaa cgagaaagcg gcagaaatct 2657941 gctctgtgac tgcaaaaaaa cgctgtttca cttgattacg aacctctgaa tcaaatgtac 2658001 gaacagtgcc ctcaatgacc actgtatccg gaatgacatt ccaagtgctg ccgccgttga 2658061 ttttccctac ggttaaaatc gcgctttgca gcgggtttac atttctgctt acaatcgttt 2658121 gcagggcgac aataagctga gaggcgccga taattggatc aaaaccatta tgcggcaatg 2658181 ctgcatgagc acctttccct tctatctcta ctttaaatcg gtcaacagca gccataagcg 2658241 ggcctgtttt taaccctaca gtcccaaccg cgatatccgg tttattgtga aggccaataa 2658301 ccgcatcaat gccatccagt tggccgtcct ctatcacttt tgtagcgcct gcacccgctt 2658361 cctctgctgg ctgaaataat aaacgaatct ttcctttcag actgtcttga ttttccttca 2658421 ataaaaaggc cgcaccaaga agcgctgccg tatgaaaatc atgaccgcac gcatgcatga 2658481 tccctttatg tttagacgca taaggcaatc ctgttttttc ttcaattggc aaggcgtcaa 2658541 tatcagccct caaagcaatc gccggacctt ctgactcccc tgctatgtct gcgaacacac 2658601 ccgtttttag agcagtaggg cgaatctgta tccccttttc tttaaggcat ttttttataa 2658661 aagcagttgt ttcaaattct tcttttgaca gttcaggata ttggtgcagg tgccggcgaa 2658721 tgccgatgag ctgcttttct agcgttgaga gatttacggg attagactcc tctttcaacg 2658781 tcaggatgtc atttcctgta gtctgatatg gataggagcc ttctatattt ctccaataat 2658841 ccaaagacat atgttccgct cctttcccta tcccaatata ttttcttcag actcttcaac 2658901 ataagatgaa ataaatcggt tcaatttatc agcaagaccg cccgccccaa atcttatata 2658961 cttgctggaa actttcggat tatcttcttt caaaaagctt aaaaaagata aaatataaat 2659021 gcgcctgtaa gctacttgtg taattccgta ctcaaaaaac cagttatcaa tgacattgta 2659081 tacgcctcgg ttgacgccat ataggttatt acatttcttg taaaagcaga gatccggaag 2659141 atttaactcc tgatgggaaa gaaggctttc ttttttgttt ggtgccataa tcccaatcag 2659201 ctcaaagcgt tttgcaacgc acgaaatatc ctttttaatt tgctttgtta aagactccaa 2659261 agaatcaaac cttctttctt ctctaatttt aaagagaatg ctgcattcga ttttttctcc 2659321 ataaatgtct ctatgaaagt caaacaaaaa aatctccaat gtcttttcaa ggttagagcc 2659381 caccgtcggt ttcacaccga tattcataac ccctaaatga aattgatgat tgactgtcgc 2659441 cagaacccca taaactccat tacgcagccc atgtattttt gcatctacat ttgccgtggg 2659501 gaatccaagc tttctgccta attgttttcc tttcacaacc gtaccggcaa tgatcgtcaa 2659561 aaaagtcagc ctcctctctc agcttccgca ttcgatcaga cgaaacctaa tgatgtgatg 2659621 aatgtaaaac ggattgatgc tgcggaatgc caagaccgag attttcccgc aatgtcccgc 2659681 cgcgataatc ttgacgataa agccctcttt cttgaagaat cggaatcacc ttttctacaa 2659741 aagcatcaag tgttcccggt atatccgacc caacgataaa cccatccgcc gcctcagcgt 2659801 tgaaccaagt ttcaattaag gatgcgacac gctctggtgt tccgatgaat agagtccgtg 2659861 gaaaagccat ttcctgtgct acctcccgca atgtcagatt tctggctttt gcttctctct 2659921 taatccggtc tgttgtgctt tgaaacgcat tctttcccac atcgccaata tcgggaaatg 2659981 gctcatccaa cgggtaaaca ctcagatcat aatcatcaaa aaaacgggcc aaataagtaa 2660041 cagcattttc aatcggtatc aattctgcaa attcacgata cttcttttcc gcctcttctt 2660101 ccgtatctgc cacaatcggg ctgatccctg gaaaaatccg cacacttgaa ggatcacgcc 2660161 cttcatcagc agctcggctt ttcacatccg cataaaacgc ttttgtctct tctaatgaat 2660221 tggaatgggt aaaaatcgca tccgcatttt tagcagcaaa ctgccggcct gtttctgatg 2660281 aacccgcttg aaacactaca ggctctccct gcttagagcg cccgatattc aagggcccct 2660341 ctacttgaaa atactttcct ttatgattca ggcgatgaag cttcgcctga tcgaaaaact 2660401 gccctgtttt cttattgtgt ataaatgcgt catgctccca ggaattccac agcccgcgca 2660461 caacatccaa atgctcttgt gcgatctcgt aacgttcagt gtgttctggc aaattagact 2660521 tactatggtt gcgcgccgct ccttcctgcg gcgaagtaac cagattccag ccggccctgc 2660581 ccccgctgat atggtccagc gacatcaatt gtctggagat agtgaatggc tcagtaaaag 2660641 atgtagagaa cgtccctact aaaccaatat ttttggtaac cgatgccagc gcagataaaa 2660701 tggtgatcgg ttcaaaacgg tttaaaaaat gaggaatcga tttttcagaa ataaataagc 2660761 cgtctgcaat gaaaataaaa ctaaacaaac ctttttcagc tgtttgcgcc tttttcatgt 2660821 aaaattcaat attcgtgctg gccgagggat caacatcggg atgacgccag ccgtcagttg 2660881 ttcccccgac accgtgaatc atggctccaa actgaataaa atctgcacgt gtcatctttt 2660941 tgcctccttt atctgtgcat gattagcaag tgcaagatca aggtgttcaa tgccgatttc 2661001 agttatccct tgatactgat tgccgcgccc gatttcgacc acaggcacat ggcgcacccc 2661061 atatttcacc tgtaaaatat cccgaagctt ttctttctct gaaacatcga tattttggaa 2661121 cgggaaccct ttttcattca aataattctt gacttcctca caatacgaac agcctttttt 2661181 actccaaacc acaatgttca caacatcact cattcttctg tccctcctta acgttttgca 2661241 gctaaaactg catcgctcag cagctgataa gacagctgtt tttctacagc atttttgatc 2661301 ggtgtaaaaa taacaaaatc attgattttg tatgtgcctg ataaacgtgt taattcttct 2661361 gccacttctt cctttgttcc ggcaataatc ccggtttttt gcacgatgat gtcatagggc 2661421 tctgtgacgt tttccagata ggcctcagcc tgttcgcggg aaccgacgtt gaccttacgc 2661481 ccgtctttca aaaccacttt tatcgattca cgcgacacaa tatgtttttc cgcttcttct 2661541 tttgtatgtg ccgcaaaaac agcgggggca agatgaaatt cagcctcaga tcctggcggg 2661601 agatgcgcgt caaatgctcg gcgggcttcc ttcagcactt cctcttcacc gttaataaag 2661661 taagcaaaga caaaagagat tcccagtttt gcagcagaaa tggcactctc tgtgcttcct 2661721 cccaatagaa aaatacccgg cttccgatca acctgcggcc taggacgcaa tgcggcatag 2661781 cggtgggtat caggaaaatc atcccgaacg aaatgagtaa gctcctccag tttttcatca 2661841 aactgacgca ccggtttttt atattcggcc tgcagcgcgt ctgtggacag ctgaaacccg 2661901 ccgggcgctt tgcccactcc aagatctata cggccgggag ctaacgctga tagaagatgg 2661961 aattgctccg ctactttata agagctgtaa tgctgcagca tcactccgcc tgatgctaaa 2662021 cgaatttttc ttgtgcttgc agcaagatag cctaaaagaa cctcgggtgc agaccctgca 2662081 atctcatcat tgttgtgatg ttcggccacc caaaatcggt gatatccaca ttcttcagcc 2662141 atttgtgcca atttcactgt atgctgtaat gtatcagctg ctgtctcccc ttcaccaatc 2662201 aagctttggt ctaaaatact taagcggatc atatcaccgg ctcctttatg tgttcttttg 2662261 gttcaaataa atattccggc gaaacacggc ggagaaactg cctcgttctg tcttttttgg 2662321 tatggcggaa gacttcctcc ggggttcctt gttcaacaat gactccttca tccataaaaa 2662381 caacttgatc agagaccctt cttgcaaact ccatttcatg tgtaacaaca atcatggtgg 2662441 ctccggtttt cacgatttcc agcattacct caagcacttc accgaccagc tccgggtcaa 2662501 gcgctgccgt cggctcatcg aacagcagca catcaggatg aatggcaagc gcccttgcta 2662561 tccctaccct ctgcttttgt cctcccgata actgactcgg ataagcgttc aatttatctt 2662621 gaagcccgac ctttctcagt tcattttccg ctacggcata cgcgtcttgt tttctcattt 2662681 tccgggcaat cgtcaagccc tccatgacat tttcaatcac cgttttgtga gcaaacaggt 2662741 ggtattgctg aaataccatt gccgtctgtt ttctgagcca gtgaacctct tttttggacg 2662801 gaaagcggca attaatcact ttgtcatgta tagaaatgat cccttcgtct ggacgttcta 2662861 ataaattcag gcaccgtaaa aaggtggttt tccctgatcc gctcggcccg ataatcgtca 2662921 caacttctcc cttgcgtacc gtgagattta tcccttttaa tacatggtgg atgccaaact 2662981 gtttatggat atttttaatc tcaatcataa agtgcctcct tgaaatctgg ctgcctttct 2663041 ctctaatact ccatttgcgg attctaggat tagagtcagc acccaataga taatcgctgc 2663101 tccgataaac gcttctaaaa atgcataatt atcagaagca acgatagtcg ccgtccctgt 2663161 aatctctggg acagccacta tagccgcgat agaggtggta tgcaaaaagc cgatacccaa 2663221 atttgtgaag tttgggatgg aaaccttcag cgcctgcggc aatattacac gccgaaaggt 2663281 ttggctgtat gtcaagccga ttgaataagc cgcttcgacc tgtccggtat ccatcgccag 2663341 aatgcccgac cggatgattt ctgtgagata agctccggca gttaaagaca aggccatgat 2663401 gacaaacatg gagaccggta tctcattagc ggaccagccg agatgaaaaa aactgctgac 2663461 ttgatctgca acaggcggta tccctaaata aatcaacata atgtgaagaa ttgcaggtgt 2663521 acttcgaaag aaagacacat aaaaccttga gcaagccacc aagcccttaa ttctaaaaat 2663581 tctaacaatt atatttccaa gagccacgag aaatccaaac acaatcggca aaacagccat 2663641 catcaatgtc agaggaatgg tctttaccat ttctttcatg gcggaaacga taaatggaaa 2663701 gtcaaattgc aatcttctcc cccctcatcc gaagaaatat atcaatgtat gttcatgtca 2663761 aaaacagtaa caatccttgt ttgattcttc ttgattcgtt tttctgccac tcgaaagaac 2663821 cattcgaata aaaccgctac agcataataa acaatcgata gcgcaatgta aacttcaaga 2663881 gaatggttgc ttgaggtaat cagtgtttgg ccccttccgg acatatccat aacacctatt 2663941 gaaaaggcta gagacgtatc ttttaaagaa ctgatcacca tgtttcccat attcggaaac 2664001 gcctggacaa gtgcctgggg cagaacgatt cgcctgaagg cctgactacc gcttaagcca 2664061 atactgtacg ccgcttccgt ttggccttta tctacactgc ccacccccgc tcgaatgatt 2664121 tctgcggctg ccgctgcatt gcttaacgcg taggttgcga cagcagcata aaacgggtcc 2664181 atttttgatg tatcaatccc gataagcccc gtaagcgccg ggatcccgta aaacacgatg 2664241 aaaagctgca ccatgatagg cgttcccctg aaaaacgaga tatacacttt tgccaattga 2664301 tttacaattg gaatattata gatgcggggc agtgccagaa agagtcctaa tacaaaaccg 2664361 aaaagcaagg acagtgttaa aatgtataat gtaaccggta aataagcggt taacgtcggc 2664421 acaaaatctc caatcatgtt catatcaaac gctttttcca tcactgctcc ctctcttttt 2664481 acctaatact gctctttgga atagtcgtca ccaagccatt tcaaactgag ccttttcaac 2664541 gttccgtcat caatgatttc ctgtaaggct ttatcaatat cgtcacttaa cgtttgttca 2664601 tttttgttaa acataaaata cactttggca tttgaaagca cattaccgac ggttttttct 2664661 ttaatagtgc tcgtcttgtt ttgaaagtct actgcaaaag gcgttgagat cgttgcgtcc 2664721 gcacgccccg atttcagctg attcgcagtc tcatttgcgc cttggccctc ataggcaatc 2664781 tcaaacggcc gtccattatc ctcattccat tttttcagta caagcgctcc gttggaggtt 2664841 gcactcgtaa tcacccgttt tccttttaag tcttcaattc cacggatcgt atcgttattt 2664901 tgaagcacag taatttttaa aggaaaatgg ttgtaagcaa ccttgttaaa cagaaatttt 2664961 ttctcacgct ctttgctttt ctccatttga tgtgccacga tatcgacttt atgctgtccg 2665021 aggctgacaa gcaggttgga aaattccatc gttttaaatg tgaatttata atgtggcagg 2665081 cgcttatcaa gctctttgat cagttcgaca tcataaccgg ttaaatcgcc tttttcatcg 2665141 ataaagcaaa tattcggaaa ttgggttcca gttccgaccg tgatcgtctg taccttcttt 2665201 tgcccggctc ccgtcgtttg actgcctgca ccgcaagctg acagaactgt tataagcgaa 2665261 aataatattg ccatgaatgc tgttttcgtt ttcatctcat cgccccattt atttttcaaa 2665321 acttgatttt gaataatctg ccccgagcca ttttcggctt agttttttta gcgttccgtt 2665381 tttctccagc tttttaatcg cttgatccgt gtcatccgcc aaggtttggc tgcctttatt 2665441 aaacataaag tacacctcgg tatctaataa cacgtcaccg actgtctttt ggcggaaggc 2665501 gtgcgtttta ttctgaaaat cgacggcaaa cggtgtagct atcgttgcat ctgcgcgccc 2665561 ggtttcaatt tgattggcgg tatcattgct tccctgtccc gcatatttca aatgaattgg 2665621 gctgccgtgc gttttgttgt actttgtaat ataatctgcc gcatttgacg tggcgccaac 2665681 tatgactgtt tttccgtgta agtcttttaa tgtatgaatc ttgtgattat cctctttcac 2665741 cgtgatgtac atcggcgagt agttatatgg gactttatga tacaaaaaac gcttttctcg 2665801 ttctttattt ttggccatat tgtgcgcaat cacatcaatt tttttatttc cgagactcgt 2665861 cagcaaattt gagaaatcca tcgttttaaa ttcaaatgta tattgaggca actccttatc 2665921 gatggctttc atcacttcaa tgtcataccc ggtcaattca cctttttcat ttaaaaacgc 2665981 aatattcgga aaatctgttc cagtgccgac tatgaccgtt tgagcctgac gatctgtttt 2666041 gttatttgtt tgcgaacatc ccccgccaag taatgcaaac actgacagca gcaaaaccaa 2666101 tcctttacgc ttattcatag gctgcctcac atcatgccca gctgggcgca cctaaaagcg 2666161 ttgggttaaa tcgttccgga atcagaacct tgtgcatcat cacacctatg tccccgtctt 2666221 tttcctgctc aaaatacact tcataccctc tccttctgta catgtcagca agccaaggat 2666281 gcttgcgcgc cgatgtgccg agtgtcagcg caggagcctt cagcatatct cgaagcactt 2666341 tttcttcaac atacgtaagc agcttacttc cggcgccttg ccctttatat tccggcagtg 2666401 tcgcaaacca ccacacaaat ggatattttg aaggaggcgt ctcactctcc cacgggaacc 2666461 tgattgtaat cgttgaaatc agcttcccat cccgctccag cacaatcgct gaatgatgtt 2666521 caatattttc tgataccatt tggatatcag ctctcgtgga tggccaatca atatccagct 2666581 gccgaatggg ctgaaatgcg ctgttaacca gtttcaacag ctccgatgca tcttcaacag 2666641 ttgccagtcg aaaaatatca tcactcattt ttgtcactcc tcttcacaaa atatataatt 2666701 cctatttgtt tactaagctt ttattgttta tactataaag catactctga tctttgacta 2666761 atcaaaaaaa gtaaaccttc acttcagtaa ttttaatgat gaaaaacagg agggagcaca 2666821 ttggagttac gctcaatcaa aacgtttcat acgattgtaa aatttggaag cttctataaa 2666881 gctgcagaaa tactcaacta ctcgcagccg acgatatcga tgcgtatgaa gcaattggag 2666941 caggatttag gcgtactgct gtttgaaaga ggaaaaagcc tgcagttgac aaaagcaggg 2667001 aagctttttt atgaacgaac aggagatctt ttgatgcaat acgaggcgct taaacacaac 2667061 ctctccgact taaaggaaga agaggcaggc attatcaaca taggggtttc agagccaacc 2667121 gccagtctga tattccccga gattttaaag gatttcttaa tggattaccc aaagataacg 2667181 gttaatatca aggttgatga cgccaatacc tgcagtcaaa agctcttaga cgggacgatt 2667241 gattttgcag tctgcggcga gccggagctg attcttgaaa attactacca tccatttttt 2667301 tatgacacat taaatgtgat tgtatctgat caacatccgc tcgctgagaa gaaggctgtc 2667361 catttgtctg atttagcaga agagcgcttc atatttacgc ccgccaattg ccccattcgc 2667421 ttacaaattg aacagcattt acatagagaa ctcgggaatc gctacaaaaa aatggagctc 2667481 acaagcagca tgtcacatga atattacgta cgtgaaaaca tcggaatttc aatctttacc 2667541 agcaccgcac attctaaacc gttcaacggc actaaagtca ttccaattct gaacctggat 2667601 atcaccccgc ccatagggct gttgacaaat caaaaagaag ttcattttga ccgcgccacg 2667661 aaggacttga tcgcccggat aaccaaacgt tttcagcagc gcagcaaaga attggaagga 2667721 acctctgata agaccattac aggataactg aaaaaataaa aaccacctcc tgattcatca 2667781 ggagatggtt tcacggttta aagctcgatc gtctcaccga ccgacatgac tttgccgact 2667841 ccgcccggca ggctgtcagc gaatgcttct gggtcttgtt cgatgaccgg gaatgtattg 2667901 taatgcaccg gcacgacctg ttttgcgcgc agccattcag cagcaagctt ggcgtcttca 2667961 ggccccattg taaagttatc gccaatcgga aggaaagcaa ggtcgatatg attcaattcg 2668021 ccaatgagtt tcatatcaga gaaaagtgcc gtatcgcccg cgtggaaaat cgttttatct 2668081 tctacagtca gcaaaatacc ggcaggcatg cctgtgtaag tgatcgtttt gttttcttca 2668141 tctgtgatgg ctgatccatg aaaggcctgt gtgagcttca cttttccaaa atcgaactgg 2668201 cgggagccgc caatatgcat tggatgaaca ttcaagcctt tccagcctaa gtacacagcg 2668261 agctcgttcg gggctataac cagcgcgtta ttttgcttgg cgatttgttc agtatcaccg 2668321 acatggtcat tgtggccgtg cgttagtaag atgacatccg cttttacatc ctccggcttt 2668381 atatccgtta atgaattccc tgttaaaaac ggatcaaaaa taatatgatg gtccttcgtt 2668441 tccactgtga ttacagaatg tccgtgatat gtcactttca tttctttcac ctcgtcacat 2668501 gattttgttt tttttatttt ccctttttaa aaagctgaaa aacttatgtt gtttgattct 2668561 tgttaatgac attgaggcct ccggtggctt caatgacagt ccctgtcaca aggtctgagt 2668621 tctcctcaca caagaaagcg ataatcctgg caatatcctc gcctgtaccg gatcttccta 2668681 tcggcgtttt ttctttgccg attcgcattc tggcttcctc tatcgatgct tctttcatgt 2668741 cgccgacaat gtctcctggg caaaccatgt tggcggttat gccgaattcg gcttcttcaa 2668801 tggcaattgt cttcgtcaaa gaagccaagc ccactttcgc agcgccaaat gccgatcggt 2668861 gaagccagcc gggcgcgtga gccgcacctt ggaatccgta cgtaataatg cgtccaaatt 2668921 gctgttttct cataatagga ataaccgctt tgaataaatg aaagacggcg cttaaatttc 2668981 cttccagcat gccataccat tcatcatcag tataatcggc taacttttta cgttcaaata 2669041 tgtatggtcc agcgttgtta atcaaaaagt cgatccttcc gaagcggttt aaggcagcct 2669101 ctgcaatacg cagcagatct tcttttttgg tgacatcacc ttttacaaat tgcagccggt 2669161 caagacaatc gggacaggct tccttcaggc ggctgactgc ctcctcatcc tgtctgtaat 2669221 tgactgttac tgaatacccc tttgcaagca acgtttcagt cactttgcgg cctaaaccct 2669281 tcgaaccggc agtaattaaa gcatgtcgca catgaatacc tcccaaagca acgtcgccgc 2669341 tttcaataaa gtgtttcttc ttctacttta ctataaaagg cttgcaatat cactttttac 2669401 actttggcat acaaaaaaag ctgcctgtac agacagctta ttctgcagga gatgaagact 2669461 cctgatcagg catatcgaca taaccgcttt gatatgcttc tgaaatgagc cttgttgtct 2669521 cctggctttc ttgttcatca taaatatagc gttccggttc ttttttcatc attctgcctc 2669581 ccatcattat agaggtaggt tggctataat gacgggattt tatgaaggaa attttaacaa 2669641 actcctgctg ccacgcaagc tttcgctttt tcaagcgcct gttccacctg tttgaatccg 2669701 gtgcccccgg cgctcattct tttttcaact gcgtagtaag ggtctaacac agtgtaaata 2669761 tcttcttcaa atagtgtgct cgcctgctga aactcgccaa acggcatatc gcttaaatag 2669821 atccctcttt cgatgcatgt gtacacaagt ttcccgacca cttcatgcgc ttctctgaac 2669881 ggcattcctt ttttagctaa ataatcggcc agttccgtcg cgtttgaaaa gtcttgtttt 2669941 gttgcttgct tcatgacgtc tttgtttaca gtcattgttt ggatcatgcc tgtgaagatt 2670001 tgcaggctgc cctccaccgt tttcaccgtg tcaaacatgc cctctttgtc ttcctgcaga 2670061 tctttgttgt aagcgagcgg aagtcctttc atgatcgtaa acagccccat catatcgccg 2670121 tatacgcgtc ctgttttgcc gcggatcagc tccgccatat cagggttttt cttttgcggc 2670181 atcatgctgc ttcctgttgc gtacgtatcg tcaagctcga tgaatttaaa ctcctgcgag 2670241 caccataaaa tgatttcttc agagaaacgg gataggtgca tcatcagcat actgctgttg 2670301 cttaaaaact ccaaaatgaa gtctctgtcg ctgacgccgt ccaagctgtt ttcataaatg 2670361 gcatcaaagc cgagcagttc cgctgaataa tcacggtcaa ttgggaaggt tgttcccgcg 2670421 agcgccccgc agccgagcgg agatttgtta atccgcttca ttgaatcctg aaaacgctcc 2670481 ttgtcgcgct caagcatcca gaaatacgca agcagatggt gagcgaatga aatcggctgg 2670541 gcgcgctgca aatgtgtgta gcccggcaga atcgtttcaa cgttcgcttc cgccttttca 2670601 atcagcgcac tttggaatgc ctcaatcagc tcgatgatgt ggccgacatg attcttcaag 2670661 tataaatgca tgtcagtcgc cacctggtca ttccggcttc tgccggtatg cagcttgccg 2670721 ccaagaggac cgatttcgtc aatgagcatt ttctcaatgt tcaaatgaat atcctcataa 2670781 tcgactgaga attccaatgc tccctcctct gctttttgca aaagggtatt caggccctct 2670841 cggattttca actcttcttc tgctgtcaga ataccgcatt ttttcagcat ggcagcatgt 2670901 gcgagagacc ctgtaatgtc ttcagcaact aaattttggt caaatgatat ggacgcgccg 2670961 aactcgtcga cccatttttc cggtgttttt tgaaatcggc ctccccaaag cttcttcatg 2671021 ctttaatctg ctccttcttt ttcacgatgc tgttcacttt tgtcggaagt ccccaaagct 2671081 cgataaatcc gattgctgca tggtgatcaa atgcatcgtc ttttgtatat gttgcaagtt 2671141 tttcatcata tagagagtat tccgatttac gtccttctac aattgcatgg cctttaaaca 2671201 gcttcacgcg gacaatgcct gtgacatgct tttgcgtttc ttttaagaaa gcgtgcagcg 2671261 cgtcttttaa cggtgagaac cataagccgt tgtaaatgat ttctgacatt ttttgctcga 2671321 tgatcggttt aaagtgggct acctctttca ccagtgtcaa atcttctaat tctttatgcg 2671381 ctttgatcag tgtcatcgca ccagggcatt cgtatacttc ccgggattta atgccgacga 2671441 ggcggttttc cacgtggtcg atacgtccga caccgtgcgc gcccgccatt tcattcagct 2671501 tcaagatcag ctcagaaagc gagtaggaaa caccgtcaat ggagacaggc acgccctgtt 2671561 caaatgcaat ttcaatcact tccggcgtgt ccggcgtttt ttccagcgga gctgttaaat 2671621 cgtatgcacc ttctggcggc gccgcccatg gatcttctaa aatgccgcac tcattggcgc 2671681 gtccccagag gttttggtcg atagaatacg ggctgtcaag attgatcgga atcggaatgc 2671741 cgcggctagc cgcatattca atttcttctt cacgtgacca ctgccattcg cgaaccggcg 2671801 cgatgacttc taggtcaggg tttaatgatt taatggagac ttcgaaacga acctggtcat 2671861 ttcctttccc tgtgcatccg tgggcaatcg cctgtgcatc ttctttttcc gcaatttcaa 2671921 ccagtttttt cgcgatcagc ggtcgagata atgccgaaac aagcgggtat tttccttcat 2671981 acattgtgtg ggcctgcaaa gagataagcg cgtaatcctg tgcaaattct tcttttgcat 2672041 cgatcacgta ggagtttgtc gcgccgactt caagcgcttt ctgctgaaca aatgccaaat 2672101 ctttgccctc accgacatcc aggcagcagg cgattacatt atatccttgc tcctgaagcc 2672161 attttattgc gacggaagta tcaagacctc ctgagtatgc taatacgact tttttctgtt 2672221 ctgacatgat aaaaatcccc tctcaaccgt gtttctattt tgtataaaaa taaattatat 2672281 ttaataaaaa tacattttgt atgtatacac tttaacaagt acgtttcgtt ttttcaagcc 2672341 ttttataaaa aaaacttcac ctaaatttca ggtgaagttt catagtattt attcatttac 2672401 ttgtcttttc tgatttctct gaccacatgc gcaagttcgg gaataatcag cttattcatt 2672461 gccagcttta ctgcgccgct tgagcctggc gttgagaaaa cagcggtatg ctgaatgacg 2672521 ccggcagttg ctctcgacat gattgcggca gagccgatat cctctgtata actcagcatc 2672581 ctgaatattt ctccaaagcc gggcagttct ttcgaaaaca gcggcgttat ggcttcaatt 2672641 gtgacatccc gatctgctat gcctgtccct ccgtttaaga gtaccgcgtc tgtctgttca 2672701 tccatgcagc ccgcaagcac tgaccgttgc aaagcatcct tttcgtcttt tacaatttca 2672761 tatgcggcaa tatgatgacc ggcttcttct aaaaatgaga tcatcagctt gccgctttta 2672821 tcggtttcat ctgtcctcgt gtcactgaca gtaatcactt tgcaccgaac gatatcggga 2672881 gcttcttgtt tatgctcttg aacgctcatt ggcccacctc ttttatgttt tctgtctgtc 2672941 actatcatgc atcaacaaaa aagcacattc aagagaatgt gctttcatgc gatttatttt 2673001 gctaaacgaa caacgtcgcg cgcaatcatg acttcttcat cagtcgggat gatcatgact 2673061 tttactggag aatgcggata gctgatgaaa gcttcctcgc cgcgcacgtt attaagcgca 2673121 gggtcccagt atacgcccat gaattctaaa ccgcgaagaa cgcgttctct gacttccaca 2673181 ctgttttcac cgataccggc agtaaagatg atcgcatcta caccgctcat tcttgcagcg 2673241 taagaaccga tgtatttgtg gattctgctt gcgaatactt caagagccgt ttccgcgcgc 2673301 tcatttcctt ctttcgtagc ttcaacgatg tcacgaagat cgcttgagaa accggaaatg 2673361 ccgagcagtc cgcttttttt gtttaatgta ttcagtactt cgtcagccgt ttggcctgtt 2673421 ttctccatga tgtatgggat cagggcaggg tcgatgtttc cagagcgtgt gcccattgct 2673481 acaccggcaa gcggcgtaaa gcccatggat gtgtcaatag attttccgcc ttcaacagcg 2673541 gcaatacttg ctccgtttcc aaggtggcag gaaatcaggc gcaagtcttt taacggacgg 2673601 ccgagaagct ctgccgcacg ctcagttaca tatttatgtg aagtgccgtg gaagccgtat 2673661 ttacggatgc cgaatttttc atagtattca tacggcaagc tgtaaaggta agactgctca 2673721 ggcattgttt ggtggaatgc tgtatcaaat acagctaccg caggaacatt tggaagcact 2673781 tctttgaacg ctttaattcc aacgatattt gccggattgt gaagcggtgc caattcagaa 2673841 atatcttcga tttccttaat ggtttcatcc gttaataaaa cagaatcgct gaatttttct 2673901 ccgccgtgaa cgacacgatg gccaattccg tcaatttcat tcaagtcttt aataatgccg 2673961 aattccgtta acttattcag cagcatttta acagctaccg catgatctgg aatatcagtt 2674021 acttctgtat ttttttcgcc gttcacagaa attgtgaata cgctgtcggc gataccgatt 2674081 cgttcaacta aacccttcgt taaaacggtt tctgaaggca tttcgaaaag ctgaaatttc 2674141 aaagacgagc ttcctgcgtt aattgcaata attttggaca tgattgacgc tcctttatac 2674201 tctgtatcaa caacttcgtt tttcgtactt ttttcccggt gaatatcaac atcttctccg 2674261 aaaaatatct gacttttcca tttaaacatt gtcatgtcgg cttttcaagt caacttgcgt 2674321 attgataacg cttacaataa gaagtcgtta ttttcagaca cattcactat aggttttgta 2674381 ttgatgaacg cttacaattt gcggtttttc cctctgtatt ttgtgtttca aagctggatt 2674441 caattcgtca agtccggtct tcaaaagcat aaataaaagc agcttaggca tcgacctcat 2674501 acggctgtct aagctgcttt taaaacactt acttttcttt tttaaaccat tcatcaaatt 2674561 gagccatcat atcaagcatc gccttttgat tggagaaaga cggaagattc gcaagcagaa 2674621 tttgccccgg cgctttcgta ttctctcctt gtttctgaag cacaaggatg cttttggcat 2674681 gagcttcgtc tttaaaaata gattttggca gctgcaacag tgcgttgata tgaaccttat 2674741 ctttgaaaaa ctgtttcagc ttgccgcttt gggagctctc aaacaaatga ttcggaatca 2674801 taaaaaataa gtagccgccc ggtttggtat gcttgacgct ctgttcaata aacagatgat 2674861 gagcgaagga atggccttcg tcagctttga gctcaaacgc ttctgctcct tcgtcattcg 2674921 gataatagcc gactggcaga tcacaaatga ccgtgtcaac tggatcgata aacaacggct 2674981 caaggctgtc ctggtggaaa agctcaagct cttttttcag aaggttcgct tgggcatagg 2675041 cgatcttcaa gagcacatca tcaatttcaa tgccaaagct gtttgccgtt ttttcagaca 2675101 gctggttcag cacggtaaac agaaggttcc cagttcccag ggctggatca agaatggtca 2675161 gttccttttt gtccgccata aatttattca ccaaatagct gatgaaaagc ccgatcgtat 2675221 ccggcgtcat ttgtctgttt ggatgcgaga tatctttcat tcctttaagg acggcaagct 2675281 gaaaagcctt gcgtacccac tcatgctcat acgtgccgaa ttccgctttt tcaagcagag 2675341 cctgaagttg tttggttttc tgatcagcag gcagtttcag ctgatccgtt ttttcaagaa 2675401 aatacatttc tcctgcttcg gccagcgcct ctatatatga aatctgcaat tcattcttta 2675461 tcataatcgc ggcttcgttt aacagctcat acaccgcacc tacatggtct ttttgcatat 2675521 tgtgttcctc cttgccatga aaaaagctcc ggcggcagcc tggagctttt ttccctgctt 2675581 actttactaa tgccttagca gcctcaattg gcttttcata gttcgggtgg tttgttgctt 2675641 cgcttacata ttcagcgtaa acgacttttc cgttctcatc aaggacaaat acggaacgcg 2675701 caagcagacg aagttcttta atatacacac cgaacgcttc gccaaatgac atatctctgt 2675761 ggtcagacag tgtttccact ttgtcaattc cgttagcgcc gcaccagcgc gcttgcgcga 2675821 atggaaggtc tgcactgatt gtgtagacgt tgacatctcc aagctttgca gcttcttcgt 2675881 taaaacggcg tgtttgtgca tcacaaacac ctgtatcaat tgaagggata acagaaataa 2675941 tcgttacctt tcctttcatg tcagctaacg atttttcttc aaggctgtta gtcagcactg 2676001 tgaaatcagg agcttgatct cctaccttca cttcttgtcc gacaagtgta accggaccgc 2676061 ctttgaatgt aatttcagcc attataattc ctcccttttg tatgtatgtc tctatcatag 2676121 taaagtttcc tgcaaactgc aaagtttatg ccaaaaaaaa gttaactgcg gccagcgcag 2676181 ttaacctttt tttaataatt catattgttc atttggtttt gattttggcc ttggctttgg 2676241 tttttgttat ttttcttgaa catttgctgg atgcgctcga gtgtttgagg ggctgcgtct 2676301 aaaattttct ctattaaatg ggtattttca tctaaatgaa gcattctgat gcctgtcgat 2676361 ccgacaatta aaaacgcgat cggcgtaatg gacacaccgc ccccgcttcc gcctccgaaa 2676421 ggaagtttct gttctcttgt ctcatcgtct tccgatttct tttcggccgg ctttccgcca 2676481 aactcgcttc cgcctgcggc gaatccgaat ccaactttag aaacagttaa aatcacactt 2676541 ccatcaggcg tttccactgg atctccgatg atggtgttaa catcaatcat ttccttcaag 2676601 ttttccattg cggttttcat taaaccttgg atgggatggt ctgccatata cgcttcctcc 2676661 ttaaactgat gaatcattct ttgaagtcat tctagccgac ggattcttct ttaatacgga 2676721 tagctcccgt ccgtatttga cgaatttgaa agctgcaagc atagcatgtc caaagcgaaa 2676781 aaagaatata cactgaaaat gggtcttgga aacagggact tgaaacgacg ggatcacctc 2676841 atagacaggt ttattcacaa agtccaggtg gtcgtagagc attgctgcga taccgccctt 2676901 cacgccccat acagcaccgg ttaacacacc tgtcactgcc gcgtcctgaa ttccgattac 2676961 tgtaacccat tctagttttg tgatatgtaa atgcgcgaga aaagacgcgc tgattttccg 2677021 cagtctggtg acctgatgca aaagcatttc gattttatta atgctttgct gcacatcgtt 2677081 ttgtgtaatt tttttctttc cgctgctttt tttcattttg gattcagttt tttgtttgat 2677141 atccactgtt ccgtcttctt tgttcacctt aatcgccggg attgtttttt tgatccttat 2677201 aaggccaaac agcgccgtaa tcttcaaggt caatttgtca ttatcatcgg catgaagata 2677261 ctccagcgcg acatggattt tcattctgag aagcagtacg atccctatga gaataagaat 2677321 ggctgtcagt acatacacca tattcttcac ttcctctagg agcattatcg ccaattccta 2677381 aaaaaataaa cccggacgga agtccgggtt atcggttatt tgcggtataa tttttcatgc 2677441 accacggtgg tatccgcgat gtaatcatga atcccttgtt ttgtaggtga aaaggcaaca 2677501 acgatatata aaatccaaat cttatcaata taccgtccaa ccacttcacg aaaaatcact 2677561 gtactccatg tcagcttgct atcttgcttc acagaaacca ctttgaggcc gaacaccatt 2677621 ttaccaagcg tctgcctgaa gtattttgtc atgagtgcga aataggcaag atacacaata 2677681 agcgttgtca cactgtaggc cgagaaggta aacatgccgg atgttttcgg cagatccaat 2677741 acggtaaaga ggggagaaac gagcaaatgg tttaatcccc atatcacgag ccaatcaagc 2677801 aggaaagccc agaaacgaac ccaaaagcca gcataggcat gtgtcagcag ctccgcttct 2677861 tgcgggcctt tgatgtcatt gcgctctaac tcttcatatg tcgcgtccat tattgttccc 2677921 tcctacttcg catagagata catcattctc ggcgaaccgg attgcgatag aatttctctc 2677981 atattcaaaa aatcaatttc acttttaaac attttgttcg cgcccatgga aaacagtgag 2678041 cctaatccga agctttcctc ataagaaatg acagaggcgt ttttcaaatc cttgtgatcc 2678101 tttttcatgg ccgtaatggt atcgtcataa aaaccaagct catcaacgag gttcagtttt 2678161 ttcgcctgcc gtccgtcata cacgcggccg tccgcaattt tctttacctc tgctttcggc 2678221 atgccgcgcc cttttgaaat gacatcaaca aagccttcat acgaattatc aaccatcgat 2678281 tgcatgatgt ttttttcttc tttcgtcatc tcacgggaag gagacataat gtccttatgg 2678341 gccccgctct taatcgtttc aaaagaaatg ccaagcttgt cggcaagctt tgaataattg 2678401 acgctttcca taatgacgcc gagtgacccg gtcagggttt ccggtgtcgc aaaaatctta 2678461 tcagccgctg ttgagatgta atagcctcct gatgctgcca tcgaacccat tgacacgtaa 2678521 atcggttttt tcgtttcttt cttgatttct tccagtttct tatgtatttc agcactttca 2678581 tacactccgc cacccggaga attcaccttc agaacgatac ctttgaccgt cttgtcatct 2678641 tttgcgcgct caaggttttt taagaacgtt ctgtggttat atccgtctgc accaagcaga 2678701 ctgcttgagt ccccattatc ctgaatggtg ccgctgacct ctaatacggc aattttactt 2678761 gagggactgc cgttttccag cgtcttctcc tgcgattcat ccgtcagtga tgtgagatcc 2678821 gtttgagcgc ctttgacgct ttcaaagaaa ctcatagaga tgctgacgat aatagacacg 2678881 ccgaaaatcc ccagagcaat cactaatgca atccatcttt ttgcattcat tttttctcct 2678941 cctttttcct aaactctctc attatacgat tcaatatgaa aaatgtttca cttcatgaga 2679001 aagctccggc ttaacgggct gccggcaaac gtggtacact tatggccaaa ggtattttat 2679061 cacaaatact ggatggcaga aaaacttaaa tatgacagca aaggggaaat gggatatgac 2679121 cgatcaacgc cgtaatgttt atttttttca caaacaggat caggaaacga acgaacaagc 2679181 ccgctcgtta acacaattag cggaagagca tggatttacc gttgtgaacc agcactcaga 2679241 cgccaatatt atcgctagca ttggcgggga cggcacattt ttgcaggcag tcagaaagac 2679301 gaattttcgt gacgactgct tgtacgtcgg cattaccaaa aaggggaaag ctcatttata 2679361 ttgcgacttt catagtgatg agcgagaaaa aatggtcgat gcaatgacgt ttgaacaaat 2679421 tgaagtgaga aaatacccgc tgattgaagt gacagtggat caagccagtc cttttcactg 2679481 cttaaacgag gtatccatcc gctcaagcat catcaaaacc tttgtgatgg acgtgctgat 2679541 tgacgatctg cactttgaaa cgtttagagg tgacggaatg attatctcaa cgcctacagg 2679601 gagcaccgcc tataacaagt ctgttgcagg agctgttgtt gatccattgc ttccatgcat 2679661 gcaggtatca gagcttgcat cccttaacaa taatacctac cggacactcg gctcgccatt 2679721 tgtcctcagc tctgaccgaa agctgaccct tcgtgtggtg caggacggca acgaacaccc 2679781 aatcatcggc ttggacaatg aagcactcag cacgagaaat gtgaaaacga tcgaaatcaa 2679841 actgtctaat aagaaaatca aaacagtcaa actaaaggac aattcatttt gggaaaaagt 2679901 gaagcgtact tttttataga aaataaaagg acaggctgct gcctgtcctt ttatgatttc 2679961 tcatatacaa tctggccgtt aatcacggtt tttttaatct ctaaaagatg aagctgtgcg 2680021 gggtcaatgg caaacggatc accactgaga actgtaaaat ccgcgtcata gccttccgca 2680081 atttttccgc gtgacttctc tttataaatg ataccggcgc taccttctgt ataaagcttt 2680141 atcgcttcat atacaggtaa acattcactt tcattatagc ttggcccgtt ttgctcatga 2680201 ctgcttttcc ggaggaccgc ggactggatc cctagaagcg ggtcaacagg ctcaatcggg 2680261 gcgtctgaac cgcccgcgca taaaatgcct ttagatatga gggttttcca ggcaaatgca 2680321 gtcttcatcc ggtcttttcc gagacggtca atgacccacg gaaagtcgct tgcaacgaag 2680381 tgcggctgaa ggtcaagtgc gatcggcatg cgtgctgctc tctcgattaa ttcgttatca 2680441 agcacttgag catgaataag ccgatcatgc cggccgtttt tgggcggatg cttttctatt 2680501 gcgttcagca ctttttcaaa agcaagatcg ccgattgcat gaacagcaac ctccatccct 2680561 ttttctctcg ctttgcgaat gagccggcca agggtttcgt catcgtgaac ctgaacacca 2680621 tttgttgatg gatcatcctg atatggttct ttcaataaag ccgttctccc gccaagcgcc 2680681 ccgtccgcaa agattttcat agcaccgaac tccacatacg ggccggacag cttctccagc 2680741 tgctcccatc gatcgacagc ttcatgatga acgagcaaat ggcagcgaaa cggatacttt 2680801 ccgccagcgg cagctttctc ataagctttc atcggcaccg aaacatcacc ataataggac 2680861 aagtcttccg aatgaccgcc cgtcaggcct tttgtccagc aatcctttat tgcagccgtt 2680921 aatgcctcat caacatagtg ctgggagact ggcgggacag ccttcagaat caaatcctgc 2680981 gccttatcaa acaggagtcc ggtcggctcg ccatttgcat cttttacgat gactccgccg 2681041 tcaggatcag gagtatttct tgaaattccc gctgcttgaa gagccgcaga attgacagct 2681101 attgcatgcc ggcatatacg cttgagcaag acgggcctgt caggaaacag gcgatcaaga 2681161 tcatgcttag tcaagtagtc aggtgtctca aactgatttt cattccagcc ttctccaatg 2681221 agccaatcgt ttttaggaag ctgccgctct ctttccttcg cagcctgtaa aattgaatct 2681281 ttcgacgtca gtgcggacag atcgagctga agctgtttct caccgtggcc gatcaaatgt 2681341 agatggctgt caacaaaacc ggggaacatc actgctccgt tcaggctgat ttcttctgtt 2681401 tccggcgacc cgtacttttc cttcaaacgt tcatagctgc cggtgccttt tataacacca 2681461 tcctcaacat aaactgcctc agtccgatcg ccttcttcga gcatcgtata aatgaaaccg 2681521 ccgtgccata tcgccttcat tcacgttcac tctctttctt tacgcctttt tattggcttt 2681581 gagctgttct tcacgttttc ttaattccac tcgtctgatt tttgcagaag ccgttttcgg 2681641 caggctttcc acaaattcaa tttctctagg atatttgtat ggagcggtaa tcgtcttcac 2681701 atggttttgc agcattttga caagctcatc actgcgtttt tcatgatttt gcaggacaac 2681761 atatgccttt acgatggagc ctctgatttc atcagggctt gcgacaacag cacattcttt 2681821 tacttctggg tgcttaacaa gcgcgtcttc cacctcgaaa ggcccgatcg tatagccgga 2681881 gctgataata atatcgtcat ttcggctttc aaaccagaag taaccttcct catcttttct 2681941 tgctctgtct cccgttagga aataatcgcc gcgaatttgt gttttcattc tttccggatc 2682001 tttaaaatac tctttaaaga gcgcaggcgt actgaggtga acagcgatat cgccaacctc 2682061 accaggtttg cagatttcac cgtcttcatt tatgatctcc acctgatttc ccggtgtcgg 2682121 ttttcccatg cttcccggtt taataggcgt atctttcaaa acaccaacca aaagcgtgct 2682181 ttctgtttgg ccatatccgt cccgtacctt aatgccaaag tgcttttgga aaacatcaat 2682241 gacttcacgg ttgagcggct cacctgcgga aacagcgctg tgcagggcag aaagatcaaa 2682301 gcgtttcaag ccttcaacct tcgccattaa gcggtattct gtcggagtgc agcagaaaac 2682361 attgattttg tagcgattta aaagctctag atatttttct gctttgaatc tgccgtggta 2682421 cacaaaaccg gttgctccgc tgccaagcac cgctaaaaac ggactccata cccacttttg 2682481 ccagccaggg gcagcagttg cccagacgat atccttttca gaaatgtcaa gccaagcgcc 2682541 ggcagaagtt tttaaatgag caaatgccca tccatgtgta tgtacaacac ctttcggctg 2682601 acctgttgtc ccggatgtat aagataagaa agccatatca tctcttgttg tgtcagctgt 2682661 tttaaattgg cttccgtccg cttcaattga taagaggttt ttccagccgg catcattttc 2682721 accaatagac agtgtaatca gtttgtcagc cgtactgaca tcccggaaag cgccaataaa 2682781 ttcggagtag acgatagcgc cttttacctc tgcatgttca atccggtatt caagatcttt 2682841 cgcgcgaagc atttcggagc acggaatgac aaccattcct gatttcagga tagccaaata 2682901 aacagcatag gcttcaagca cccgcggaac cattacaatc agcttgtctc cctttttaaa 2682961 tccaagatca gctaaggccg ctccgatttt atttgtttct tccatcagct tttcatacga 2683021 ccaagattct tgcttgcccg actcgtcctc ccaaagaaga gcggtttttt gtccagcagc 2683081 actgaacttt tccatttcat tcactaaatt atattgcaca ggggcaatta aatcttcacg 2683141 ttttaacacg aacaactcct cactttctcc acccattata cataaataca ggctctttcc 2683201 gtaaggatat gcctaaaagc aacctctgta aacatagatt ttataggccg ctggtccttt 2683261 tttatatgta aaaaatgaaa aagagtgggg atacccccac tcctaagcca ttatgtgaaa 2683321 ttgtaaatta gaattgtcct ccgcccatgt tttgttgagc aaaagataca agacgttttg 2683381 tgatctctcc tccaacagaa ccgttagcgc gagaagttgt gtctgctcca aggtttacac 2683441 cgaattcaga agcgatttct aatttcattt ggtcgatcgc ttgagcagct cctggtacta 2683501 aaaggttgtt gctgttacct gagttattgt tagccatgtg tctcacctcc ttgtgagtat 2683561 agaatgtgtc aaaacacatg gcttcattca gaaaaacttt ggtaattgta tacaggagct 2683621 gaaaattgat ttaaaagagt tcagcgaatt tatcgttagc ttcttgttcg ctataaaggg 2683681 tcattgtctc aatgttatct accgcttctt gaatatacgg ctcgaaatca acaaagcttt 2683741 caaagtgttc aattttctct tttttagggc gtgttttcgg gcttggcggt gtaaagatcg 2683801 tgcagcagtc ttcaaacggc tgaatacttg tctcatatgt gccaatttcc cgtgattttt 2683861 cgatgatttc tgttttgtcc atggcgatta gcggacgcaa aatcggtgtt gacgtcaccg 2683921 cattaattgc atacatgctt tcaagcgttt ggctcgctac ctgaccgagg ctttctcccg 2683981 taataatggc aagcccgttt ctcttttctc tgattctgtc ggctatctga agcatgaggc 2684041 ggcgggttgc cgtcattgtg taattttcag gaatttgttt ttggatgagc tcttgcgttt 2684101 ttgtaaatgg aacaatatga agtgtcatgc ttcccccaaa acgggacaga catttcgcca 2684161 gatccattac cttttgcttt gcgcgctcgc ttgtgtatgg cgggctgaag aaatgaacag 2684221 cttctaccga caatccccgt ttcatcgcat aaaaaccggc cacagggctg tcaaaaccgc 2684281 cagaaagcat cagcatcgct tttcctgctg aaccaactgg cagcccgcct gcaccttttt 2684341 catcacgaat tgtcaaaaat gttgcttctt ccctgatttc gattctgagc gggatgtctg 2684401 ggttgcgaac atcgaccgtc aatccttctg tatttcgcaa aatatggccg ccgatttcag 2684461 cgttcatctg gtttgtatct aattcaaatt gcttatacgc tctctttgtc gcgactttaa 2684521 acgtatcacc tggtttatac tgatctttga tagcctttag tgcggttgcc ttaatatcat 2684581 caaggcggct gtcacactta attgccaggc tgaagctttg aatcccaaac acttgcttta 2684641 aatgaggaaa aagagcctca ggatcctctc catttaatgt aatcgtcata cgatccctgt 2684701 tggaaaagta ttttaaattc ggatagtctt tcaaaacgag tctgatgttt tgttttaagc 2684761 gctcaataaa gctttttctg tttttgcctt tggtcgaaat ttccccaaaa cgaattaata 2684821 tatgatcgta attcatgttc tacctcatca tttcccttaa ttttttgatg ccaggacgaa 2684881 gcgcgttcat aaacggttct gccacatcgc ttgtctggct gtaatttaaa ctgattctga 2684941 tgctgcttcc ggcaatctgc tctcctttgc ccatctctaa gagaaccttg ctgggcttat 2685001 gttcttttgc cgagcaagcc gatgttgtgg agacgaatat atcctgttcc tcaagcatgt 2685061 gtaaaagcac ttccgcttta atccccggta cagagaaatt aataatgtgc ggcgcgctat 2685121 tcatttgagg cgtgttgata acgacgccct caatttcact cagcctattc ataaacaatt 2685181 cctttacggc agtcatcgtg tcaagccgtg tgtcaaaatc agcagaggcc agattaatgg 2685241 ccttggcaag cgaaaccgca ccagcagtat gttctgttcc ggcccgtatg cctttttgct 2685301 gagagcctcc cgttatgagc ggaataaggc gtgttccttc ttttacaata agtgcgcctg 2685361 tcccctttag gccgtgaaat ttatgccccg aaattgaaca tagatcaatg ccggcctttt 2685421 caattgccaa gggcacttta tagatgccct gcacataatc gacgtgaaac aaaatgttcg 2685481 aatgctcttt cagcacttct cctgccgctt caatcggctg cacggaaccg acttcattgt 2685541 tcacatgcat catgctgaca agcacggtat cgggacggat ggctgctttt agatcttcaa 2685601 tagaaacaaa tccgtcttca ttcacagaaa gataagtgat atcaaacccg aacaactctt 2685661 tcagctgttc taacgattcc gtaacggatg gatgttcaat agaagtggca atgatatgtt 2685721 tgcctgtttt tatctttgac aaagccgctc cttttaaagc cgcattattg gcttctgtgg 2685781 cgcctgacgt aaatacaata tcatattttt ttaggcctaa ggaccttttg atttgatttt 2685841 tggctgcttg aagcagctgt tccgtttcgg ctccatatcg gtgcaaagat gaaggattgc 2685901 caaagtatcg gctgctcgtc tgttcatata cgttcaagac ttcatcgtaa ggcttcgtcg 2685961 ttgaactatt atctaaatat atcatctttt ttactccttt atgaaagcgg tacaaggtat 2686021 gatatttatg ttaccataac aaaatttaat agaaaattac gaaaaactag tattgacttc 2686081 taattttttt accatataat aagatttgtt cgtttcgtca tattatctga caattaattg 2686141 acagaatatt ttaacataat tattaggagg atttttttca tgaaacactc actgcctgtc 2686201 aaagatacca ttattattgg tttcatgcta tttgcgttat tctttggagc aggaaatatg 2686261 atttatccgc cggaacttgg acaagcagcc ggacacaacg tctggaaggc catcggcgga 2686321 tttttactga caggggtagg cctgccgctt ctcggcatta tcgccatcgc attaaccggt 2686381 aaggacgcta aaggccttgc tgacaaagcg caccctgttt tcggcacaat ctttactgtc 2686441 gtgctttatt tatcaatcgg accattattc gccatcccga gaacaggaac tgtttcatat 2686501 gaaattggcg ctgttccgtt tttgactggt gtaccagaaa gactttcttt attaatattt 2686561 acacttatct ttttcggcgt tacgtactat ttagcgttaa acccatctaa ggttgtggat 2686621 cgagtcggaa aaattctgac tcccatcaaa ttcacaatta ttttaatcat tgttctcaaa 2686681 gccatcttca cgccgatggg cggattgggc gccgtgacag aagcatataa aggaacaccg 2686741 gtttttaaag gatttttaga aggctataaa acaatggacg cacttgcttc aattgtattt 2686801 ggcgttgtcg ttgtaaatgc tgtaaaaagc aaaggcgtta cacagtctaa agctcttgct 2686861 gcagcctgca ttaaagcagg tgtgattgcc gctttaggcc tgactttcat ttatgtatcc 2686921 cttgcttatt taggtgcaac aagcacaaat gccattggtc ctgttggtga aggagctaaa 2686981 attttatctg cgtcttccca ttatttattc ggttcattgg gcaacatcgt actcggagca 2687041 gcgattacag tcgcatgttt aacaacaagc atcggccttg tcacatcttg cggccaatat 2687101 ttttcaaaac ttattccggc attatcatat aaaattgtcg ttacgattgt cacgttattc 2687161 agcttgatca ttgcgaattt cggactcgcg caaattatcg cgttttctgt tcctatttta 2687221 tcagctatct atccgcttgc cattgtcatt atcgttcttt ccttcatcga taagatcttt 2687281 aaagaaagac gcgaagtgta catcgcatgc ttgatcggta caggactttt cagtatttta 2687341 gacggtatca aagcagccgg tttttcactt ggatctttag atgtgtttct aaatgcgaat 2687401 cttcctcttt acagcctcgg catcggctgg gtgcttccag gaatcgtcgg agcggttatc 2687461 ggctatgtgc tgaccttatt catcggacca tccaaacagc ttaatgaaat aagttaatgt 2687521 cacagaacgc ctgcgttatt gcgcaggcgt tttgtaataa aaaaagagcc tgctcattac 2687581 actgcgggct ctttttcatg gtcgtgatta tctaagcgga tatgtcagct ttgatttttt 2687641 caactgcacc tggcgcagcc ttttctacag cggcagcggc aatttcataa gagtcgtcat 2687701 aatcaaaagc ataaaaacgt ctttccgctt ctttcagctg ttcagataaa atatgattct 2687761 ggcttctgaa ccggtttccg aactgaatga ttttttcaat gaggatgacc tgctcgacaa 2687821 gttcctctga ttcccggctt gccctgttga cgatatcttc tgcttgtttc aaatgggctc 2687881 cggcttcttc catatttaat ggaagttcgt ttagttgatt gaccgtttct tgaatatgat 2687941 gatgcgcgtt ctccagcatc tcttgaatat ggctcggaat gcctggaatg ttgctagtct 2688001 tcagcagtct tgctgtctca gaaattgttt ttttcaaatt gctgagcgtc tccctcgcct 2688061 gaagctcttc ttttctcagc gcttgcagat tttcacgata ctcggcatgc tcttttttca 2688121 cttcttcaat ttgcttctct attgaagcaa cttcttctac taaaagtgag taggcgacat 2688181 gctctgcatc aagcttatct ttaacggatg atagcagctt tccaatttca tcaaggcgct 2688241 tttcaaaagc ctgctgtttg ccgagctcac cggctgtcag cctgtagctt tccttcacca 2688301 gctcagtttc cgctttcgta tgctctttct cttctttaag cttgtcgtaa gcaataatca 2688361 attcaggcat tttgcttagt acggattgac cggcttcaac ttcgccctcc agctgctgat 2688421 aaacagattg aatattttcg tcaatgagct gcaggattgc ggacgcttca tcaatatcca 2688481 gttcagtcat caggacatgt tccgctcgtt tcagctggtt tgacagattt tctaattcct 2688541 tatcaagctg gatatgctca agcttgtacc ctttttcttt catttcgcca tagccatcct 2688601 tgagctttgc aatctgtccg ggcaccgtct gtttacagtc agctaacagc ttcggcacat 2688661 catctatgta tgactgaagc cgttcaagat tgcggtcctg ctcaagcagt acttttcgtg 2688721 cagtaatata gtttccgcct tctgtttctt cttcaaattg tttgatgccg ctccaaattt 2688781 cgtccagatc cttttcaagg ctgtcataaa gctccccgta aaggtggctg taagccagca 2688841 ggttttttcg agatttcgaa tagcgctccc tcacctgttc aatctcttca cggctctttt 2688901 cctcacttgt gacaagatcg ctgatttccc gaagaatctt ttcaatgctt gattcagccg 2688961 ctgtcagcag gtcgtcgata tgaacgagca cttgattggc ctttttaaac cggtatttgt 2689021 ctgcattttc ctcggcatca taaaggagct cttcaacttt cggcatgtgg gctgtgacaa 2689081 tctcatccca ttcttcacgc cacttctcaa agaactcttc tgtctgaccc gtcattttta 2689141 aatgttttat tttagacatt tcttccacga tcgaccgatt cagaatttca atcttccacg 2689201 attccagccg gtcgatttcg gcgtagattt ttttcctgaa aaagtagcct gccgcaaaca 2689261 gcgcaagcag tacaattaat aatccaatga caaactccat aatgagcccc cttgctgttt 2689321 accttaatct gtcagggtgt tttatttatt cagaaagatt tcaggatatg tattgagaaa 2689381 aactgtcgtt ttcattgtta ttatgatacc atgtaacaaa cattttttga ccagaaatca 2689441 aaaacttttt gtgcaaaatc ggcaggattt gactattttt tcatggggtg acatcaatgc 2689501 aaaagcgaga cggacatatt cacacaccat tttgccctca cggctccaat gacacactca 2689561 gacaatatgc agaagaagcc ttaaaaaaag ggttcgaatc gattactttt accgaacacg 2689621 ccccattgcc gccatctttt accgatccca cgccgctgaa agacagcgcg atggcgcaag 2689681 cttctttgga acgctatatt catgaaattt ccggattaaa aaaagaatat cgcggacagc 2689741 ttagcatacg gacagggctt gaagtcgatt atatcgctga atttgaagac gaaattacat 2689801 tattcctaga cacatacggg ccatatttag atgacagcat cttatccgtt cattttttgc 2689861 gcacagactc ttcctatcta tgccttgatt atgacgagca taccttcaaa gagctgattt 2689921 cagcctgcgg aagcattgaa gcggtatatg aacaatatta ccggagtatc tattcttcca 2689981 ttgtagcatc tctcggcgtt tataagccaa aaagagtcgg tcacatcaca ctcgtccaaa 2690041 aattcatcaa gctgtttcca tacagcatgt cagagcatat tcgcggcctc gtttctctgt 2690101 gcctgaatgc cattgaagaa aacggaatgg agctcgactt caatacttcc ggcttaagaa 2690161 aaacttacgc tggcggtatt tatatcgagg attggatgct gaatgaagcg aagcaaaaga 2690221 agatcccgct tgtgtttggg tctgatgccc atcaagcggg agatgtcgga tatgcgtatg 2690281 aggcgttttt ggaacggtgc tagttggtga gcgccacgtc tcctgtccgg aagacgcttc 2690341 tgatccaaat cttgatttct tcaaaataca ttttataaaa atacggctcg tgcggctgca 2690401 tgtagagtac ttctgaaata tattgaggct ggagataggg catcatcaag agagatttta 2690461 attggagaat aaaatgaggc agcggcagcg ttaaatattc acgctgtttt tctccttcct 2690521 caatgatcag ctggaagata tacttttcct tcattagata tgtcgacata atttccctga 2690581 ttaatgtgga gtcaattgtg acttcccggt agacaaaacg agttaattga cgatgattat 2690641 gctgatagga taaaatatcg aaaaccaatt gaagaagctg ttcctgcgtg ctttgagtag 2690701 agatattgct tgccgctgtt tcaagcgttt tgctgtagcc ttcgtaaaac tctgaaacta 2690761 agtgttccat caagcctcct ttgcctttaa aatagtagga gatgtgcgca acatttacat 2690821 cagctgactt tgcgatttca cggacagacg tgccagaaaa tcctttttgg ttaaaaagca 2690881 tgacagcaga ttcaataatt ttgtctttgg tgcttacttt catacggctc actccttcct 2690941 cttgatacta ttcaagcaga aagccgctgt tcctgtaaga acttatcgac aaatgccggc 2691001 agaaaagccg gaactttgtt ttatattata gaaaaagtga gggttttcca tgttccatgt 2691061 cgaaaaacaa tctggagata aagaaaaaga ctatcagctt ctgctaaaac agctcgaagc 2691121 catgaccgaa gacgaaacag accaaatagc taactatgca aatgcctcag cactgctgta 2691181 tcattcgctg cctgaagtca actgggcggg tttctatttt gccaaagaag aggatggaca 2691241 gcttgtgtta ggtccgttcc aaggcctgcc ggcatgtgtt cggattcctt tcggcagagg 2691301 ggtttgcggc acagcgtacg caaacggaaa agtggaacgt attgaggatg taaacgcgtt 2691361 tccgggacat atcgcctgcg atgcagcgtc tcaatcagaa attgtgcttc cgattcgtgt 2691421 agacggaaaa attgtcggcg tcttggacat cgacagccca gtgaaaaacc gtttcgacga 2691481 aattgatgaa aaatacttaa ctcaatttgc cgaaacgcta gaaaaagcgt tagcgcagta 2691541 atataaaagc ccaaaactga tatcgttttg ggcttttttt attttattga gtcatgaatc 2691601 atcaagcggt ttttcccgct ccgtttcgcg ctgtagagcg cttcatctgc ctcatgcaca 2691661 agctctttca gcgacttttt tgtttctgtc gtccagcagg agataccgca ggaaatggtt 2691721 acctcgggtt tcgtattttt tctgaccgcg taaaccagtc gctcggtaat ccgtttcccc 2691781 actgcaaccg gcacatttgg caaataaatc gccagctcct ctcctcccca gcgggcaccg 2691841 acatcatgct ttcggatgtt gcttttaatc actgaagcga cttgaattaa aatctcgtcc 2691901 ccagtctgat ggccgtacgt atcatttaca tttttaaaat tatcaatatc aacaagaata 2691961 aaaacaccct tttgatggat tttcatgctg tattgaattt tttcatctaa atacgctcgt 2692021 gaatacagtt cagtcagctg atctgttttc acgagatgct caaggcggtc gcgaagcatt 2692081 gaattggtta cagccagtgt cgcgtgatga atcagcgcct gaaacagctt gtacatttca 2692141 aatgtaaaag cgtacagctc ctgtttcaat aaaaccgcaa agcctaaaag ccggtcgttt 2692201 tgaatcatcg gagcagccat cagcgagccg taccccgcct tcccaaaaac agactggcca 2692261 ttcccgatga aaaccccttt ttcaccttca tacagctttt ctttcagctc attataaaaa 2692321 tctgacggct tcgcttcttt aaaaaatgct gtgctgcctg ggagcaatgt taggttttca 2692381 aaatggtcta tatgaaaaaa tcccacttct tctgcctgaa acgattctgc cattctcaca 2692441 gccagatcat tcattgtatc agtcaatgtc agccgctgat tcaggcgtcg tgatgtttca 2692501 ttaatcaatt ccaaatttgc gatgcttgct ttggattgtt cgtagagctg ggcattttca 2692561 aacgcttttc ccgcggcgtt tgctaacagc gacatttcat caaggcaggc atcagtaaga 2692621 aagctgtcac ccgttccttc agccttcaac accccgtatg tgccctgctg tcctttgatc 2692681 ggaatatagg cgacagattc atttttccgc aaaatgtctc cggacaaata cactttgagc 2692741 gcaaaggaat cggatttttc cccttccata tacagctctt ttgcaggaat ccctaaacat 2692801 tggtcttgat cgtgcgatat aaataaagaa aactcaaaaa gagaaaatgt gcttgtcaag 2692861 ctttctaaaa gctgcttcag cacatctgtc tgatcaagca gtgaatggaa cagctctgtc 2692921 attttgtata tctttttttg gtagatcgtt ttgttataga gtctttcctg tttcatcgac 2692981 tggtttaaaa atgaagcaac cacgtccgga agcccttcag gaatctcttc atcctgcctg 2693041 cacgcaagat ggaaacgcct gccggagccg tcctcaatca gataacatga agcgtttatt 2693101 tttgaagcgg aaaaacgcgc ttcaccatct gccagttttg tcacaaagtc tgatggtgac 2693161 ggtgtaagcg aaacacaaag ggttgaaaaa taggtttgaa tagccgaagt cagccatatg 2693221 aaagagtcgg tgaatgtgac tttttcagat ttggttaata aaaaatcgag catatgataa 2693281 tgaaaggcgg ataattgatc tttagtttgt tctaccatgt ttttatcacc taaaagttta 2693341 ccactaattt ttgtttatta tatcataaac ggtgaagcaa taatggagga atggttgact 2693401 tcaaaacaaa taaattatat aatgaccttt gtgtgaaata ttgcagcctt tttgttcagc 2693461 ttctatgttt tcattttgtt ccttatcaat aaggtgtatc gtgtaactct ctgctgctgg 2693521 agcgaggata catgaaaaca aaatgtgcat ggtcgaatag agcagacggt ttttattttc 2693581 cacaaaaata aaaccaaagg aggagtcaca ttatggctcg ctatacaggt ccatcttgga 2693641 aactgtcccg ccgtctagga atctctctta gcggtacagg aaaagaatta gaaaaacgcc 2693701 cttacgctcc aggtccacac ggcccaggac aacgtaaaaa attatcagaa tacggtttgc 2693761 aattgcaaga aaagcaaaag cttcgtcaca tgtacggtgt aaacgaacgt caattccgca 2693821 ctttgtttga caaagctggc aaactagctg gtaaacacgg tgaaaacttc atgattcttt 2693881 tagattctcg tcttgataac gttgtgtaca agctaggttt agcacgtact cgccgtcaag 2693941 ctcgccaatt ggttaaccac ggtcacattc ttgtagacgg aagccgcgtt gacatcccgt 2694001 cttacctagt gaaacctggt caaacaatcg gtgttcgcga aaaatcaaga aacctttcta 2694061 tcatcaaaga atctgttgaa gtgaacaact tcgttcctga ataccttact ttcgacgctg 2694121 aaaagcttga aggtactttc actcgtcttc ctgagcgttc tgaacttgct ccggaaatta 2694181 acgaagcgct tatcgttgag ttctactctc gttaatcgtt ttaaaaaccc ctgccgctat 2694241 gcggtcgggg tttttttatc ggctttcgcc tcttgctggc caacactatc ttgcgcctgc 2694301 tgctcccaat gatcccgctg cagccgttct tttgcaatcg tacacatgag attcacgctt 2694361 tagcgctcct ttcatttaaa aggtggtgat tggtcgtgtt tgccctatct aatatactct 2694421 tttcctttca ttcctatgcg gtaaacaaaa agatcctttg ccttcagtgg caaaggatct 2694481 ttttcttatt tatacgtcac aaggaagtat tttttcttcc cgcggcgcag aacagtaaat 2694541 tggttttcga tgcggtcttc acctgatagg gtataattta tttccgtctg gcgttcaccg 2694601 ttaatgtaaa cagctccgtt ttggatgtct tcacgcgctt ggcgtttaga aggagataat 2694661 ttagattgca ccaacacatc tacaagtgaa agctcttggg tgctgtcaac ttccatagaa 2694721 ggaacatctt taaagcctac ttttacgtct tgagcagaaa gctctttaat attgccgctg 2694781 aacagcgctt gggagatgtt gatggcttgc tccagcgcct cgcgtccgtg aacaagtgat 2694841 gtcacttctt ctgccaggcg tttttgcgct tcacgttttt ctggcgccgt ttctgttttt 2694901 tcagcgtatg cttcaatttc ctcttttgaa aggaacgtga agtatttcaa gtatttgaca 2694961 acgtcacggt cgtctgtgtt gatccagaat tgatagaatt catatggcga tgttttttct 2695021 ttatcaagcc agatcgcgcc gccttccgtt tttccgaact tcgtgccgtc tgcttttgtg 2695081 acaagcggaa tcgttaggcc aaacgctttt gctccttctt cttctgattt tctgatcagt 2695141 tcaagacccg ctgtgatgtt gccccactga tcgcttccgc cgatttgcag tttacagttt 2695201 ttgtctctgt aaagatttaa gaaatcataa gattgaagaa tcatgtagct gaattccgtg 2695261 tacgagatgc cggattcaat tcttgagctg accgtatctt ttgccagcat gtaattgatg 2695321 ccgaaatttt taccaacgtc acgaaggaaa tcgatcacat tcattttgcc gatccagtca 2695381 aagttgttcg cgatgacagc tgggttttct gctgcttcaa aatctagaaa tctggacagc 2695441 tggtttttga ttttttggga ccattcggat acgatgtcag cagtgtttaa tgtacgctct 2695501 gctttttttc cgcttggatc accgatgagg cccgtcgcgc cgcccacaag cgcaatcgga 2695561 tgatgccctg caagctgaaa acggcgaagt gttaaaatag gcagcaggtg tccgatatgc 2695621 aagctgtctg ctgtagggtc aaagcctgag tacaagcgga ttttttcttc attcagctgt 2695681 ttatttaacc cttcttcatc tgtcatttgc tgaatcaatc cgcggaagga taagtcttca 2695741 agtaagttag tcataagata aagctccttt tttaattaaa ataaaaaacg ccccttcgtt 2695801 tacacgaagg gacgattgat tatcgcggta ccaccctact aataagagaa tgcaaacatt 2695861 cgtcttatca ctttgcctga taacggatca ggtccgttct ttcactactg aaagcctggc 2695921 cggctttgtt tgcaaaagcg gttcatgagt gtattcgata tatccgtctg tgctgatttt 2695981 caccggccat cagctctctg gaacgtaagg atattctact tgtctcaatc tttacctttt 2696041 catatgaagc tatatcattt ttaacataaa taaaatcctg tgtcaacgcc gccttttaat 2696101 cctccattgt tgacagatct ccagccggca gattaagctc ccatgccttc agcacgcgcc 2696161 tcatgatctt tccgcttctg gttttcggaa gcttatcttt aaattcgatc tcacgcggag 2696221 ccgcatgggc tgcaagaccc tgctttacaa ataggcggat ctcttctttc agtttatcag 2696281 acggctcaaa tccttccctg agtgcaataa aggctttaat gatttctcca cgcaccgggt 2696341 caggctttcc gataacgcct gcttctgcaa tagccggatg ttcgacaagc ttgctttcca 2696401 cttcaaatgg gccgacgcgc tcaccggagg tcatgatgac gtcatcaact ctgccttgga 2696461 accaaaagta tccctcttca tccatgtaag cagaatcccc agacacatac cagccgcccg 2696521 gcatgaaata cgattcatac ttttcagggt tattccaaat ggtatgcatc atggaaggcc 2696581 agcccttttt gatggcgaga ttgcccattc ggtacggcgg tagctcgttg ccttgattgt 2696641 caacgatcgc tgcctccact cctggaatcg gcttacccat tgaacccggt ttaatatcca 2696701 tgcaaggata gttgcagatg agctgactgc ccgtttcggt catccaccag gtatcatgga 2696761 ttcgtttgtt aaaaacttta tgtccccatc tgatgacttc cggatttagc ggctcaccga 2696821 cactgagcac atgccggagt gaagttagat catatttcgc agccatttca tctcccgctc 2696881 ccatcagcat ccgaaaagct gtcggcgcgc tgtaccagac attgacgcca agctgttcaa 2696941 tcgttccata ccagctttcc gggctgaaac gtccgccgac gatgacattt gtcgctccgt 2697001 tcagccacgg tgcaaaaatg ccgtataccg tacctgtcac ccagcctgga tcagccgtgc 2697061 accaataaat gtcttcttcc tttaaatcaa ggacccactt tcctgtttga tattgctgaa 2697121 tcatcgcttc atggacatgc aacacgccct ttggcgtacc agtggaacct gatgtatagt 2697181 gaagcagaaa gccgtctttt ttatccatcc attcgatatc caatcttgtg ctttcctgtt 2697241 tcgctgcttc atcataattg atgatattcg tgccgctctc agcctctccc ccgactacga 2697301 agacatgctg caagtgaggc agtttgtcta ccggtattct ctccagcagc tcaggcgttg 2697361 tgacaacaac ctttgcctca ctgttttcaa gccggtcttt caccgctccc tccataaatg 2697421 cttcgaacag cggcccggcg atggcgccaa ttttgattgc gccaagcata ataaaataaa 2697481 gctcgggtga tctcggcata aaaataaaaa cgcggtcccc tttttccaca tttccatacc 2697541 gtctcagcac attcccggct ctgtttgatt cttccttcat ttctttaaat gtgtattttt 2697601 catccctttt tgcgtcttta taataaagcg ctactttgtt ttttcgaaac gattcggcat 2697661 ggcggtcaat cgcttcatac gccgcattca gtttccctgt ctcatgccaa gagaaatgtt 2697721 tctctgcctc ggcccaatca aaatgccggt acgtttcttc atagtttttt aagttatgat 2697781 ccccctctat tgctggtaac gctttcaagt tcatgcccaa acatccccct ttgctgaagt 2697841 tgtcacaatt attatagtat atattcatat tcttctcaat ttttaaaata taaaccatgt 2697901 tgaaaacgct ttataatttg gtattcttaa agaaggcatg tatttttgat aagaattgat 2697961 gggacggtga attagtggaa catcataaaa cataccattc agcaaacatc aaaacagcaa 2698021 ccggctcttt actgatagaa gggcctgtct ctccagagga tttggcaggt tatgagtttc 2698081 ataaagattt aaccgcattt cgcccgcctc gcgagcagca tgaagcgcta gtcgacattg 2698141 caggccttcc cgaagggcgc attattattg ccagagacgg ccgaaccatt gtcggctatg 2698201 tcacgtattt atatcctgac ccgctcgaaa gatggtctga aggaaatatg gaggatttga 2698261 ttgagctcgg agccatcgaa gtagcgccgg actatcgggg atgcgctgtc ggaaagacgc 2698321 tcctgaccgt cagcatgatg gatgaacaaa tggaaaacta cattgtgatg acgacagaat 2698381 attactggca ttgggattta aaagggatga aaaaagatgt gtgggaatac agaaagatca 2698441 tggaaaagat gatgaatgca ggcggattgg tctggtttgc aacggatgag ccggagatca 2698501 gctcccaccc tgcaaactgt ctgatggccc gcattggaaa aaacgtcagc caagaatcaa 2698561 ttgagcaatt tgacaggctc cgtttttatc atcgttatat gtattaactg acactgacaa 2698621 aggggaaaaa ataatgattg ttgagcaaat catgaaaaga gatgtcatta cattaacgaa 2698681 gacggatacg cttgaaacag caatatgcaa actgaaggaa ttccatatca ggcatctgcc 2698741 tgttgtagat gaagaacgac acgtgatcgg catgattaca gacagggaca tgaaacaggc 2698801 cagcccgagt atttttgaag aaaacaaacg aagcctattt ctcacacgaa gcgtagattc 2698861 aattatgaaa aaggatgttg tctgcgccca cccgttagat tttgtcgaag aaatatcagc 2698921 cgtgttctac gagcatggca tcggctgcct accagtggta caccatcaaa aattaatagg 2698981 cattttaaca aaaaccgatt tgctgcggac gtttgtcaaa ttgacaggcg ctgaccagcc 2699041 gggctcgcaa attgagataa aagtaaacga catcaccaaa agcctcgctg agatcagcag 2699101 tctttgccaa gaccttcaag tgaaaatatt aagcgtgctt gtttatccgc atgacgatcc 2699161 cggtgtaaaa gtgcttgtct tccgtgtaaa aacgatgaat ccgctgccgt ttttgcaggc 2699221 attacaaaga aatggacacc acgtcgtatg gccgtcagag caaagggatc tgctatgaga 2699281 gacagtgtat ttatctattc tccatcctac caaacctata tgtttcatca ggagcatccc 2699341 tttaatcagc agcgggttct gttaacatat gatttgctta agacgatcaa tgcctttgat 2699401 gatggagaca ttgtcacccc cagactcgct tcagaagagg agctttccct tgtccacacg 2699461 gacgattaca ttcaggccgt aaagcttgcg ggcgccggaa agctccccgc tgaagaagga 2699521 gaaagctacg ggctcggcac tgaagacaca cccgtctttg ccggcatgca cgaagcggca 2699581 tcactcttgg tcggcggcac tttaacggcc gcagactggg tcatgtcagg acaagccctg 2699641 catgcggcaa accttggcgg agggcttcat cacggctttc gcgggagagc atcaggattc 2699701 tgcatataca acgacagcgc tgtggctatt caatatatcc agaaaaaata tagcgccaga 2699761 gtgctttata ttgatacgga cgcccaccac ggggacggtg tgcaatttac attttacgat 2699821 aatcctgacg tatgcacgct gtccattcat gaaacaggaa ggtatttatt ccctggaacc 2699881 ggtcagatcc aagaaaaagg aagcggaaaa ggatatggct attcctttaa tattccgctt 2699941 gacgctttta cagaggatga ttcttttctt gaggcttacc ggacagcagc ttcagaagtc 2700001 gccgcgtatt tcgagcccga tgtcattatc agccaaaacg gcgccgatgc ccattactac 2700061 gacccgctga cgcatttatc agcaacaatc aatatatacg aagaaatccc ccgtcttgca 2700121 cacactttgg ctcatcaata ttgcggaggg aaatggattg cagtcggagg cggcggatat 2700181 gatatttggc gtgtcgtgcc ccgcgcctgg gccagaatat ggcttgaaat gaagggaatt 2700241 gacccgggtc acgagatccc gccggaatgg attgttaaat ggcaaaaaca atgccccgtg 2700301 gcccttccgt cgagctggag cgatccggct gatttatatc ctccgattcc ccgcaagcct 2700361 gaaattacag aaaaaaatgc ccaaactgtc agcaaagcat tatatgcgat acgttctgaa 2700421 cagcaaagaa caaagtaaaa aacgaccttt acgaagaggt cgtttttgat tttttaatca 2700481 ctatttccac acgccgattt tccttcatgt gttcatttgt cttgttatcc tttactggct 2700541 ttgtatccgc ataaccgaca gcaataaagc gcttggaggg aagcttctct ttagacgtga 2700601 agtattgaat cactccactt gcccgtgctg ctgatagctc ccagttcgac gggtatcggt 2700661 atgtcgaaat gtttcggctg tctgtatgtc cctcaacctg aatgtcattt ggaattgttt 2700721 gaagaagaac ggcaatttgg tgaagaagtg tttcggcatt tttcagcacc tttgcctcac 2700781 ctgtatcaaa cagcacagcc tcctgaagaa cgagcacgac accgcgttca tcccgtttgg 2700841 ctgtcatttg ggccttcaaa tgattgtctt ttatatatgt atttactttc ttgagaagct 2700901 gatcctgctg atcctcttgc ttcttcgtat cagatgggga tgtattcttt ttttctatgg 2700961 atgtttggtc cggctgaagc ccgttgcctt ccttctggat cgagtccact gccgctttga 2701021 atttttgcag atcgatttgg gacatcgaaa agagtaaaat aaagaacaca aggatcaagg 2701081 tgatcagatc tgtaaaggtt accatccagc tggatgaaga ttgactgttt tttccgcttc 2701141 cattccttct ttcaaaacgt tctcttctaa gcttcatgta cagatccctt ttttgttttt 2701201 acttgttttg gctgcttctg ccattcttcc cgtgagctga aaacgaccag ctggctttca 2701261 aggttgcgcg ggttttttcc ggattgaaca ccgataatcc cttccaccat tacctgcttg 2701321 atgaaaattt cactttctgt tttctcttca agcttagccg cgatcgggtt gaagaccata 2701381 tttgccagta atgaaccata taaagtcgtc agaagcgcaa tggccatgtt tggtccgagc 2701441 atatgcgggt cgtttaagtt tttgagcatc agcacaagcc cgacgagtgt tccgatcatt 2701501 ccccatgccg gagcgaattc tcccgctttt tcaaaaactc gccgcccttt tcggtgccgt 2701561 tcctccattg ctgcgatttc tgaatccatg acgagccgaa tcgtttcttc atcccagccg 2701621 tcaatcgcta aaagcagccc ttttttcaag aatggatctt tgatttcccg agcctgatca 2701681 tccaatgata aaagcccgtg ttttcgcgcg tgatcggaaa gggaaacaaa ggttttcaca 2701741 agatctttca cattgtcttc ctggcggatg aatgcctgct ttaacacaga gggcgctttt 2701801 ttcagctcac ttggcggaaa actgataaaa acagcggcgc aaagtccccc tgttacgatg 2701861 aagaaagagg tcagatcaag aaaagagcgg aaaccgctta ctcccgatcc tgaaataatc 2701921 ccgataacaa taataatcgt tcctaacaca aatccaacag gtgtaagata atcaaaacgt 2701981 ttcatcattt ctccccatga aaaaagcaag aattcaccat aaaggtgaag cttgctcttt 2702041 gtttttctta tgacttggtt gactttctaa gctctatacg gtgcggcagt tcgacgatat 2702101 gctcttcaac cggctcttta ttcatgagct tcgtcagcag tctcatcgca acggcgccga 2702161 tatcatatgt cggctgaaca actgttgaaa gctgaggacg aaccatgagg cttaatcttg 2702221 tattatcaaa accgataatg tcgagatcct ccggaatgga taagccctga tcctgagcgg 2702281 catggataat gccgagtgcc atttcatcag ttgcagaaag aatggctgtc ggttttttat 2702341 ccaggctcat cagatgctgc agtgcttcga gtccggaatc atatgtgtaa tccccttcag 2702401 ctacaaattg ttcattaaac ggaaggttcg cttcttcaag cgcacgtttg tagccttgga 2702461 gttttttcga acggttgatc ggttctgcca ttggtccgga aacgaacgcg atgtctgtat 2702521 gtcctttatc aaccaaaagc ttcacggcat cataaatcgc ctgttcgtaa tcgatagcga 2702581 ctgacggtgt ttcctcctgc tcttctacag aagcggcaag tacaatcggc actggagaac 2702641 gcttaaattc cgccacatgc tcgtccgtaa tgtttccgcc cataaacacg atgccgtcca 2702701 cttgtttgcc gagcattgtg tttaacaagt gcagctcttt ctccatgttt tggtcagagt 2702761 tgctcaaaat aatattgtat ttatacattg tcgcgatatc ttcaattccg cgcgcaagct 2702821 ctgaatagaa aatgcttgag atatcgggaa tgatgacacc tacagttgtt gtttttttac 2702881 ttgccagccc tcttgccacc gcgtttggac ggtaaccgag acgttcaatg gcttccaaga 2702941 cttttttcct cgttgtcggt tttacattcg ggttgccgtt cacgacacgg gaaacggttg 2703001 ccatgcttac attagcttct ctcgctacat cgtagatcgt aatattgctc atcctaaaac 2703061 cactcctttt actggataca cttatcctta tctatagcat aaacacttta tgtagagaaa 2703121 tgtcataatg tccgaattta tgtcgtttat gatttgtaag cgtaagtcag tagtgtacat 2703181 tatttttcat tattcatcaa atttaattac ttctcatgaa attatacacg tttttataga 2703241 tgatgaaaac gtatacttgg tttttataac taaataaacg agaaagcata aaaaaaggcc 2703301 gcaggcgcgg ccttttggat tgttcaatta agcgttgact ttcaccattg gcttcagttc 2703361 attcagccat ttttcgaatt caggaatcgc catttgctga gcagagtcag aaagtgcgac 2703421 tgacggatca gggtgaacct cagccattac gccatcagca ccgatcgcta aagcggcttt 2703481 agctgtcgga agcaagaggt cacggcggcc tgttgaatgc gtaacatcaa caaagactgg 2703541 caaatgcgtt tcttgtttca aaatcggcac agctgaaata tccagcgtgt ttctcgttgc 2703601 tgtttcatat gttctgattc cgcgctcaca aaggataatt tggtcatttc cttgtgacat 2703661 gatgtattca gcagcattga tgaattcaga gatcgttgca gcaagaccgc gcttcagaag 2703721 cactggcttt ttcacggcgc cggccgcttt cagcaattcg aagttttgca tgttgcgcgc 2703781 tccgatttga atgacatcaa tgtagtccag cgcttcttcg atatgagccg gagttacgat 2703841 ttcactgata accgccagat caaattcatc cgctacacgt tttaaaattt gaaggccttc 2703901 aacaccaagc ccttggaaat cgtatgggct cgtacgaggc ttaaaggctc caccgcgcaa 2703961 aattttaatc ccttgttttt tcgcagctgc agcgacttca gctacctgct catagctctc 2704021 taccgcacat gggccgacaa tgaatctttg ctggccgtct ccgatttttt cgcctttgat 2704081 atcaacaatt gtatcttcag gttttttctt gcgggagaca agcagcgctt tgctgtgatc 2704141 ttcttcctga agctctaaac cggctttgaa tatctcttta aaaatgtgct ggatggttga 2704201 attttcgaac ggcccgtcat tgttttcaat gatattgttt aacattgtgc gttctctgac 2704261 agggtcaaat cggttgacac cctgtgcttc cttcgcttta ccgatctctt ttacaacatt 2704321 gccgcgttcg ttgattaatt ttaaaatttg taggtttaat tcgtctgctt tctgccttaa 2704381 aagctctaac tctgtgttgc tcattttttt catcctttcc ctgcacattc attttttatt 2704441 ttgtagttat catgcatctt actataagta attccaaatg gaaatactga aatacaaaaa 2704501 attttataaa aactctactt tattacccaa acgcttttaa gtgataaagt aatctatgaa 2704561 gctatcctac atgatgtgag ggcaatgttc aagggttttt tacaaaaaaa agcgccagat 2704621 gatatctgga cgcttttttc tatgacaaat gctgctcaat agcggcttct gtaatttgtg 2704681 aatgtgaggt atgccatttc acttcaccgt tctggatgat gaatatctga gggctttcat 2704741 gcttgacccc atatgtttct gcaatgaaat tggacagcgg ccgggcttct tgtacttgaa 2704801 gatagtaagc cggcacatcc tcatgctgat ttgcaaaggc atcaaactca tgaaatgctg 2704861 cctggctgat cgggcatgtg gtgctgtgtt tcaagaagac gaaaacgcct tcctgttctg 2704921 caatccgttt aaattcttcc tcagattgaa taagctgttt agccatgact caagctcttc 2704981 cttccctgct cagcgattca actgctcagc ctgtttttgt gcatctttca gttcgtcttt 2705041 tacatcttct ttcgtctgga ggacttgatc ttttgtttca tcagctgcct gcatcgcttc 2705101 ttccctcata tcttgcattg cagtcgatga atccgttttg tcagatttgg aacggtctct 2705161 caaatccttt accttgttca tgatctgtcc agactgatcc gctacaagct gtgtgatgtt 2705221 ggaagttttg tcttttgcga tgctgacata ttgcgtgcct ttttccttcg catctgccgt 2705281 cattttatca gttttgtccc gtaaggcaac agcctggctg ccgagatcgt cgcgaagttc 2705341 tttgcctgat ttaggcgcta gaaaaagagc tgtagtggca ccgatgattc ccccgattaa 2705401 agttccgatt aaaaaatctt tactattaat tccatctttg ctcatcatta ttcctcctct 2705461 tagtattttt ttctcttaca gggctgattt tttcttttgc ttccatttct cccaaatttc 2705521 cattgctgct tgactccaag tgacaacttg attgatctta tcttgattct ctctaactga 2705581 tgccgataca gaccctgccg cttgtttcat ggatgtattg aactgctgta cagaagctcc 2705641 cactccttga acagcatgaa cgaccgtgtt cagcttttct gatttttcct gaatatcttc 2705701 agccaggcgg ttggtcttat gtaaaagctc ggctgtttca gttgtgatgc ccttcatttg 2705761 tccctccagc ccttcaagag tggatgcgac gttttttagt gtcagctgca gtgacttcaa 2705821 tgttttagac aagtagatca ctaatacgag aaatgcaact gcgatgagtg caacgctcaa 2705881 ataaagaata ataatcatct caaacctcct tgctgcagga tatactgctg tttacccgtt 2705941 ttcttcaatc ataaacatgt gtactgggct gtatacatac tattctccgt tatgtaagaa 2706001 aatcctttaa taagctttcc catcagataa ataaaaagca gtgagatcac tgctttttat 2706061 tatgccatga cgttttcgta ggctctcata tatttttgga tatctcctgc tcccatgaag 2706121 atgagaacgg ctttatcatg agcttttaaa acagatgtgt catcttcttc aatcagcttg 2706181 gcattatgaa tttttccctg gagatcaccg atcgtcagct ttccggcatt ctcacgggct 2706241 gagccgaaaa tatcgcataa atacacacag tcggcgccgc tcaggctttc tgcaaattcg 2706301 tcaaggaact gctgcgtccg ggtaaatgta tgaggctgga ataccgcgac aatttcccga 2706361 tcaggatact tctgtcttgc cgcctcgatt gtcactttta tttctgtcgg atgatgggca 2706421 tagtcatcaa tcagcacttg atccccaagc tgcttctcat tgaatctgcg tttgacgccc 2706481 ccaaaggatt tgagagcatg cttaatgatg ctggaatcaa tttcttcata atggcataac 2706541 gcaatgaccg ccaatgagtt taatacattg tggtggccgt acgcaggaat ataaaacgta 2706601 tcatagaacg tattgcggac aaagacatca aaagttgtcc cttccgtgct ttttacgatg 2706661 tttctggctt gaaaatcatt ttcttccccc gtgccataat acacaaccgg gacgttcgca 2706721 tggattttcg gcagatgctc atcgtctccg caggcaataa tgcctttgtt gacttgaaga 2706781 gccatctctt ggaaagcgtc aaatacatcg tcaatgcttg agaagtaatc agggtgatca 2706841 aaatcaatat tcgtcataat cgcataatct ggctgatagc ttaagaaatg gcggcggtat 2706901 tcgcacgctt caaacacaaa gtattcgctg ttttcatttc cctggcctgt tccgtctccg 2706961 attaagaaag acgtcggttt tgcgttttgg atcacgtgag ccagcagacc cgtagtcgac 2707021 gttttgccgt gtgcgcccgt aacggcaaca ctcgtgaatt ttttcatgta gtcgcctaaa 2707081 aacttatgat aacgtatcac cggaattccc tcagacatcg ctttttctat ttcaggatgc 2707141 gtgtctggga atgcgtttcc ggcgatgact gtcatgccgg gtttaatatt ttccgcgcta 2707201 aaaggaagaa tcgtaatatt tcttttttca agcgctgttt gcgtaaaaat aaatttttcg 2707261 atatccgatc cttggacagt atatccatta tcatgaagta tttgggcaag cggactcata 2707321 ccggtccctt ttattccaac aaaatgataa acagtcataa ttgtacctcc aacaaacgtc 2707381 tatctgttcc ccagtatatg acgctcattt caatttgcga ccgcggcggc tgaaaagcct 2707441 cccttagcgg cgtattttat atgttttgtt atgtttagta tcaggttatt tctttccgat 2707501 taaacccaga tatcaagatt tgtctatgca cagctgctgt aaagcggcat agctgttaaa 2707561 tgctctaaac actatcatac catgtttggt gtgaaaatga acccatatta ttcgtttatt 2707621 aaatcacttg ctgtgatcag cacctctcga ggcttgcttc cttttgcctc agagatcatg 2707681 ccttccgctt ccatcatgtc gatcagcctt gccgcacgat tgtaaccgat tctgaatctt 2707741 ctttgcaggc ttgaagtgct cgcactgttt tgctctacaa caaactcaca cgcttcgtaa 2707801 aacagttcgt cctcttcttt cagggcagat ccttgtctta cgagctcttc ttgttcaaat 2707861 aaataggtcg gcggcatttg gcttctgacg tgggaaacga cgcggtcgat ttcccggtct 2707921 gacacaaagt taccttgcag acgaaccggt tttcccgagc cgttttccaa aaagagcata 2707981 tccccttttc cgagaagctt ttctgcaccg gctatatcaa taattgttcg ggaatcaacc 2708041 tggcttgaga cagaaaaggc gattctcgtt gggatattcg ccttaatcag acctgtaatg 2708101 acatcgactg acggacgctg agttgcgacg agaagatgga taccgcacgc tctggctttt 2708161 tgggcgatcc gcgcaatgct ttcttccaca tcgtttggag ccaccatcat caaatctgca 2708221 agctcatcaa taatgacaac taaatacggc agcttttcac ccatttggtg ttcagcggtt 2708281 aattgattaa agcggtcaat gtcgcggaca cctgaatggg caaaaagctc atagcggcgc 2708341 tccatttcct caacgaccca tttcaaagca gccgtagccg ctttagcatc agtaatgacc 2708401 gggctgacga ggtgaggaat tttattgtaa ggggccagct ctaccatttt cggatcaatc 2708461 agcagcacct ttacctcact cgggtcagct ttataaagca ggcttactaa tattgtattg 2708521 atgcatacgc tttttccgga gcctgtagcg ccggcaatca agccatgcgg cattttcttc 2708581 aagtcgataa caacaggatt tcccgaaata tctaatccca gcgcagctgt gagcggtgac 2708641 ttgcttgtcc tgaaagctga gctgcgaatc atttggcgca aatcaaccac cttgctcgtg 2708701 cggttcggca cttcaattcc gatcgtgttt ttccccggaa tcggcgcttc aatccgaata 2708761 tctttagctg agagactgag tttaatatca tcggacaagt tggtgatttt attcaccttt 2708821 acacccggtt caggatgcac ttcaaatctc gtgacagacg gaccctgggt tacatggacc 2708881 acattggcgc ggacattgaa atttttcaag gtcaaatcaa gaagctgacg ctgttcttcg 2708941 atccacgcag tatcatcttg aacctgcgct ggcgggacat caagcagtgc aacattcgga 2709001 aatacatagc tgccgcggcg ctcctctgct ttttgctgtt tatgcgtatc tcttttcagc 2709061 atcatcacat taaaaggaac ggatggccct ttttgagaag atgcgctttg ttcagtcctt 2709121 ttctcctgta caccaggcct ttttttcggc tcttctgaag cttcgcgagg tttgtctgcg 2709181 cgaatttcct gccggttttc aagagttgca gtagacgatt tggaaccctg ctccatgtgt 2709241 tcagttttct caagctctgt atggctgtct ggctgaacat ctatcttcgt ttcctgagcc 2709301 tctcccaggg tgtcataatg attatttatt atgctttctg atggctcttc tgattctttt 2709361 gccacagttt ctgcttgagc cagagcctct gatgaatact catgatcagt aaataaaggc 2709421 tcttcctgac gaatgtccat ttgttcttct tgaacgaacg gggactcagc accttctgcc 2709481 gcgttttcat gatgattgta tactgggctg tctgacggct cttttgcttt ttcatcctca 2709541 gatactgcct ctgtctgaga ttcaggagct gtttgctctt catcaagttc agcggagaaa 2709601 acaggctctt caaatttctc tggctgctgc tccctttgtt cttcctcagc cgttgcaggc 2709661 tcttcgcggc ctacttcact gtctgaaagc ccttcagccg ccgtatctgt gagcatctca 2709721 ggcggtgttt gctcttcggc ttgttcagct gggaagaaag gctcctcttt ttccggctgt 2709781 tgaacgcctg actcaaatgg cactttgtta cctgacggct cggctggccg tttcgccagc 2709841 gcctcatcat gctccgtatc ctttctgttt aaaacgccag aaggctgttt ttcaaattgg 2709901 gtatccggga agaaaggact ttctattttg gaatgcgcct gtgtgtctga agcaggatag 2709961 ccgcgttcac gttcgatctc ttctgacagc agtgttacct tctcttttac cgatttatcc 2710021 ggttcgttca atgtttcaga aggctttttc ggcacatcct ttttaacaga tggtttttga 2710081 ttgaatccat agacaggcga agggatattt gtcggtttaa acggtttctt cgccggctct 2710141 gctgcttgat atgtatgctg ctcttcttca tttctgggac gctctctgta aggtgcagca 2710201 cttggacgag gcgcggattt cggttcgtcc gatggtgtgc ggcgccttct caggtcatga 2710261 tttttgtatc cgtcaggcac gactggaaaa cggaatttgc cttttggata ttcataatat 2710321 attttaggat cttccaatct ttttaattgt ccttcaggat gatgtacttc ttgttgctgc 2710381 ggaatttgag cgggttttgt ctcccgttca gcatcctctt cgctttcgcc taaaaacaaa 2710441 tcaaaaaatt tatgaagcca actcataatt tatctctaac tcccttatag ttttctggga 2710501 cggtttttag tataccactg ctggtcggcc cagaaaagat taagctatca gcagaaacaa 2710561 agccgctaaa caagggctta gcggcttttc acatgattcg ttttttttgg cggatttatg 2710621 ggagtctaaa actgaaatgc gtctcccgcc tcatagtctc cttctaacac aaggattcct 2710681 ttttcagcag gggcatccgg caaatcaagc tctttcgctg agcagatcat cccgcttgac 2710741 ggaacgccac gaagctctgc atccttaatg acaagtccgc taggcatcac agcaccgact 2710801 ttggcaacga caactttttg gccttggtca acgttaggcg cgccgcagac gatctgaagc 2710861 gtttcttctc ctacgttgac tttacatacg cttaatttat ccgcattcgg atgtttttct 2710921 tttgattcta cataacccac aacaaacttc ggagataaat caacgactaa tgtttcttca 2710981 acgccgtttc tgtttaaaat ctcattcaca tcttgcacga atgtttctga gagcgcaaca 2711041 gggccgtttt catcaatggt caagtaagaa gacgcattga aaatgttgaa gcccgttgtt 2711101 tcttttgttt cgttattgaa aattttgacg acgtcgccgt gtttttcata gcctaattgt 2711161 tcgcgtgtca catcttgaag agagatcagg agcgtgtctc ccacaccttc tttattataa 2711221 aaagcgttca taagtaaaaa tcctttctaa tcctttttcg gacggctttt cgccaggata 2711281 aacaccggtt ccagctttcc ttcattgtac aaaaatgata gggcggtaat cgggacggtg 2711341 ccgcctgcaa agaagctcat cgacatttgt cctagaatat cataccccga ttcattccgg 2711401 atgtcagcaa gaatcaaaac gtcctgatga ggaacagaga tcgccagctc accttctgca 2711461 tgctgcttat actcatttaa gatcgcttcg ttcaaaatcc ggcttgcgtc gtatccgtcg 2711521 tttgccctga agaaataaaa gtaattgccg gcaaccgtat cctctttgac aaccgtcggc 2711581 agggaacgga gattaaatgc ggccgtctct ctgatccgct cttttgtcca gttttctttc 2711641 tcaagcatgc gctggtcaat taaacggtag gttttcccga gatctagcgc gtaataaatt 2711701 cttgtctctg cggtatgatc gtcataaatg agcgggatat cttcgctgga cttgtccggg 2711761 aaggaagtcg agcggatgac cggataaatg cgagtttctt tcccggtcat ttcctgagcc 2711821 ttcccttcca ttgccgtcat cgcttcggag acatagtaca cgatctcatc aatggcttcg 2711881 tcttttttca gttcccattt tgcaataatc ggcggcaaat cgagtgtaat ccctttttta 2711941 gtcgtttgat cctcaacacg gagggtgtct ttttctctgt caaacagaaa ggagcgattc 2712001 tcgtgctgaa ggcgctgctt cagtatatct gacagcttcc ttgaggtcat tttcaaaccg 2712061 atgtcctcct ttacgcttta gcgagagagt ctgttaaaaa ctgttcaatt tcttcttttg 2712121 ttttgcggtc tttgctcaca aaacgattta cttcttttcc ttcattaaac accacaaagc 2712181 ttgggattcc gtaaatttcc cactctgcac atgtatcaat gaatttgtca cggtctacgt 2712241 agtagtaggt gaattcaggg aaattcgctt ccagttcagg caggaaaggc tctacaaaac 2712301 ggcaatccgg gcaccaatcg gccgaaaaca taaatacaga ccaatcatcc tttaccgctt 2712361 tttccagctc ttgagttgat tcaatttttt tcatttcata tccctccagt tgtttatgtt 2712421 cttacatgtt ttttatcgat actcgtccat ttggatcata ccaaactgct tgaggcaaaa 2712481 ccacttatat gcaacgaatg aatatgtaag attggctttc ccattatcat tatcatattt 2712541 tatttgcatt atcaagctcg tttcgtttaa catcgtgtac atgagggtga aatttacaga 2712601 tggatataca taaggaggga tttttattat ggagtttatc gtctatttag caggagaaat 2712661 ccacagcaat tggcgcgagg aaattaaaga aaaaacaaaa tcactgaagc tcccgattac 2712721 gtttgttggc ccgatggaga atcatgaccg ctcagacaat attggtgaag aaattatggg 2712781 cgtacagcca aatgccgttt taaaggatga caaagcctct gacatcaaca acttcagaac 2712841 cgccgtcctg atgaataaag cagactttgt gatcgccctg tttggcgaaa agtacaaaca 2712901 gtggaacacg gcaatggatg catcatatgc gatcgcaaaa ggaaaacccc tgattatcat 2712961 ccggccggaa tcgctccacc atcctttaaa agagctttcc aataaagcga atattacggt 2713021 tgaaaccgtt aaccaagcca ttaaggccct ttcctatcta tttgaaacag aataagaaaa 2713081 aagcttgtcg atccgggctt actgctcgtt caacaagctt ttatgaaacc tacatatttt 2713141 ctttaatcgc atccactgtc tgcttatcgc aggctgttac aagtttgatg agcatttctt 2713201 tagcagcagc ataatcatca atatgaatga tagtagcgtt tgtatgaata tagcgggaac 2713261 atattccgat aaccgctgac ggcacaccgc tgttcgaaat atgaaccttg cctgcgtctg 2713321 ttcccccgcc ggatacaaaa tattgatatg gaatatcatg cgtttcagcc atatcaagaa 2713381 cgaattccct cattccgcga tgcatgactg tcgttctgtc aagaatgcgc agcaaaaagc 2713441 cttttccaag ctggccgaat tcatttttgt ctccgctcat atcgtttgcc gggctggcgt 2713501 caagggcgaa aaacaagtcc ggtttaatca tatgagaagc cgtctgcgcg ccccttagcc 2713561 ctacttcttc ctgaaccgtt gcacccgcat agagtgtatt cggaagctct ttaccgtgta 2713621 attccttcag aagttcaatg cttaagccgc atccatatct gttatcccat gcttttgata 2713681 aaattttctt ttcattcgcc atcgtcgtaa acggacaaac aggcacgatc tgctgtcccg 2713741 gtctaatgcc gattttgatg gcgtcttcct tatcatccgc tccaatgtcg atcatcatgt 2713801 ttttgatatc catcggtcgg tttcgctgcg catctgtcaa taaatgcggc ggtatgcttg 2713861 aaatcacacc cggaaccggc ccgttatctg tttgaatttc aacccgctgc gcaagcaaaa 2713921 cttggctcca ccagcctccg agcgtctgga atctgagcag cccgttgtct gtaatggatg 2713981 tcaccatgaa gccgacttcg tccatgtgcc cggctaccat aattctcggt gcgtcctctg 2714041 cgcctcgtct gactccgaaa acacttccca gtctgtcctg aacgatgtca tctgcatatt 2714101 tggctagctc ctgcttcata aaagcacgaa cctgatgctc attgcccggc gcgccgggaa 2714161 gctgcgtcag tgtttggaaa agcgctttcg tttcttgatt catgttttcc cctcatttct 2714221 atgtagtcct tttattttat tagaaacaat gaagttttcc aagcactctg acccaatctg 2714281 ctcgatcagc cgcgtattgc ttaacaggat ttggctgttt ctgtataatg aaaagtacga 2714341 tcaaccagga ggtgctttat tttgaaattg cgtcatcttc ttttaggagc aggacttgga 2714401 atttgtacgg ctgtcgttgt gagacaatat gtgatgaagc cttatatttc ttcagaaaaa 2714461 gcgcttcgaa ttgtaaaatc tgcttttaag cagcggggcc cgattgacgg atcatggatt 2714521 tacacccagc cggagcccta caatattaac ggagaaacgg tacaggtata caaaaccggc 2714581 attacacgat cagctttcgg agaattagaa cagtatgaag tcatggtgga tgcgaaaacg 2714641 ggagaaattg ttgatgtcat tgatacaatc gcctcttaac accggacaag caaaaaatag 2714701 aagccgctgc ctatgcagcg gctctttttt attatatcgc gcgaatcggt ttgtataccg 2714761 gataccacat cgcatcctgc actgcctgta taatgtcttc aggctcttcc gtagcgacgc 2714821 cttccttcat tgcggttttt gcaacttcaa cagcaacggt tgccgaaaca gtgcgcaaat 2714881 cttcaacttt tggaagcatc ggcgccccag gcaccccgac attgaccata cctgcgattg 2714941 cccgggcaca tgcttcaaac atgccgtcgg taattaattt tgattttgta acaatcgttc 2715001 caagaccgag accagggaag acaagcgcgt tgtttgcctg cccgatatga tacgtaactc 2715061 cgttatattc aactggcggg aacgggcttc ctgtcgtgat cagcgcacgg ccttctgtcc 2715121 attcgattaa atcctccggc tttgcttcag aaagagttgt cggatttgac attggcaaaa 2715181 tcgccggccg tttcacatgt gacgccattt cttttacaat ttcttcagtg aaagcgccgg 2715241 aaaccgtaga tgtgccgatc aggatcgtcg gtttcgcctg ccgaaccact tcaagaagat 2715301 caatgcctcc gccgtctccg ttccgctgat aatccttcac ttcatcagcc gaacgggcat 2715361 acggcttttg gaaatcaaga agctgatcca tatcatctgt taacagcccg ttcctgtcta 2715421 tgcaccagaa gcgcttgtat gattcttctt cactcagtcc ctcgcgcacc aatgcttccc 2715481 gcagctgttc ggcaattccg attcctgccg ttcccgctcc gaatataaca actctgtgat 2715541 ctctcagcgg aactttagac gcttttgcac aggataagac tgcggccaaa gaaacagcgc 2715601 cagttccttg gatatcatca ttgaaggtac acactttatc tttatagcgt ttcaaaatgc 2715661 ttcgcgcgtt tttcgccccg aaatcctccc aatgcagcaa tgcattcgga aatgtttctc 2715721 tcgccagcgc aacgtagtcg tcaataaatt ggtcataacg ttccccgcgc actctggaat 2715781 gctggttgcc gacataaagc gggtcgttca agaggctctc ctgatttgtc cccgcatcta 2715841 aaacaacagc cagcactctg ctcggatcaa tgcccgcagc cgctgtataa accgccagct 2715901 tgccaataga aattgcgatt cctccgacgc cccagtcacc gattcctaaa attccttccg 2715961 catcagttgc aacaattaaa tcgatcgtat cgctttgatc tttatactgt ttaaaagctt 2716021 ctttcatacc gtccgggtca tcgattgaca gatagagccc tcgtggtttt ctgtattcat 2716081 ggctgtatct ctgaattgcc gttccgactg tcggtgtgta gacaatcggg agcatttccc 2716141 ctaaatggtc atttaacagg cggtaaaaca gcgtttcatt ccgatcgtgc agcgccgtta 2716201 aatagacatt tttgctcaaa tcgtcaggct gtgcggaata ttgttcatac gctcttttcg 2716261 cctgatcatc aattgttaat accttgggcg gcagaaagcc ttttaaacca agttcttttc 2716321 tttcttcctc agtaaaagca acacctttgt tcaaaaaagg aacagagagc acttcaaggc 2716381 ctcttaatgt tgtttgaatg tctccttcgt ttgttactct gaattgtttc accctgcctc 2716441 ttcctttctg agcataatag tactaggttt gcattattag ccggaaaaca tgcagggtaa 2716501 acataaaaat atgctatcgc ttcattcgct taactgactt tttgatgctt ccgtcctcct 2716561 cccattgaag ggcgcgatac tcggcatcat ggtaaaaaat aaaccaagca tctttttctg 2716621 ctgcgaacgc ctgccatttc tgcttttgcg ggatagaggt catcggataa tcatcgtaag 2716681 ccagcaccca tagcggattg cggtgggcat gtgtcggcat cagatctgcc atatgtacgg 2716741 cagtttcacc cgcatcctcg catatcagga cactgtgtcc gtcgctatgg cctccggtgt 2716801 gatgcattgt aataccctct gtgatcgtta aggtgtcttc aaaggttttg acttggccag 2716861 ctacagcctc ccaattttct ttccaatacg tatttttcga cctgatattc ggatggcgca 2716921 tttcgtccca ttcaacagct gatgtataaa tcactgcatt cggaaagaca gagacgagcc 2716981 gttcaccttc atattccgtt aaaccgcatg catgatcaaa atgaaggtgt gtcattgcga 2717041 tcacatctat atcggcaacc gttaatccga gtgcagctaa tgagggtttc acattcgact 2717101 cttgtgtcac gccatagttt cgtttttgtt tatcagtcag cttgccgtac ccaattccgg 2717161 cgtcaatgat gatattgagc ccatcctttt gaatcaaaat agggtctgtt cttagttcaa 2717221 tctggttttt ttcattgact ggatattttt tagaccaaag cggctttggc acaacgccga 2717281 acatggcgcc tccgtccata tgcgtcacgc ctccgtcaag ccaggtcaac gtgatgtttc 2717341 caattttcat tgtttccatt ttcacccccc cctatcatca tggtagcaaa cggcccataa 2717401 aaaaaacaga ctcctgtcag agtctgtctt tacgttctcc attcaacctc agcccgatag 2717461 atcggctggc cgagtgcaga gaatttttct tcatattctg tcataatatt gccttccaga 2717521 ttgctgttat gcaaatcgag actgacgtat gtcagcagga ggccgtactc agagaagctc 2717581 ttcaaagagt actcaaataa acctcggttg tccgttttaa aatgaatcga tccgcctttg 2717641 cccattactt cttcatattt tttgaggaag tgggaatatg tcaggcggcg tttttcatgc 2717701 cgtttcttcg gccaaggatc agaaaagttc aagtagaccc gtttcacttc ccccggctca 2717761 aacacatccg tcagcgtgtc cgcatctata ttcagaagct ttacattctg cgcttcgctg 2717821 tcttttactt tttggacggc tgtcacgatg acgcttttaa ataactcaat accaatataa 2717881 ttgatgtcgg gattttgttt ggccatacca gaaataaatt ggccttttcc tgtaccaacc 2717941 tcgatatgga tcggattgtc gttgccaaac actgtgttcc atttcccttt ataatcagca 2718001 ggattgctga tggcaatatc tgcgttttca gccaaaaagt catcagccca aggcttgtgg 2718061 cgcattctca tatgattgac acctctatct attatttcga ctaacaacat accatgaatt 2718121 aaaaagaccc gcaagctcgt ttttccagtg tatctctctt aaggccgagc gcataaaaaa 2718181 agagggtccc gtctgctgga acactccttt cccatgtata aaaacgctct gttttgaaca 2718241 atttaacccg tatgatactg aagggatgtg taccgttatg ggtttacatt atgagcatca 2718301 agttcattta ttgaaggata tattgactga ccatcaattg gactgctgcg gaacagtcgc 2718361 agagtacgag cagcttgagc gtgtgattaa atcactgatg gcaaacaccg agcttgattc 2718421 aaatttcaaa aacgtgcttg aagatgttta ccgctacagc caatcaggaa tatcgtccaa 2718481 atccatcgac tcacacatac aagagcatca gaacagcctg tctcaatggg tagagcaaat 2718541 ggattcgtat tcctgattaa tcaacaattc gtttcatgag gatatgcagc tcttccattg 2718601 catcatgaaa ttccttatca ttgccttttg ctttatgcca ggcaatgaaa gtaattgttt 2718661 cagataacac ataccaagcc attcgcaacc gaaggctttc tgtcagctct atgccgtaca 2718721 tgctcagcca gctctcccaa gctggctttt cgacgtagtg gtacagcaaa ggcccgaggt 2718781 ccatcgccgg atcagcgatc atggcgccgt cccagtcaat taaatacagc tggttgtctt 2718841 cagacaatag ccagttatta tgattgacat cacaatggca aacgactttc tcaccgaaat 2718901 gcacttcatg caggtgttct tccaaatact tgatcccttc ttgaatcagc ggcgaagatt 2718961 gctgcacagc aaatacagcc tgcttcagct gagacaaaag agcccccggg ttcagcggtt 2719021 cttttccaag tctcttcagc atgtccagca aggcttttga tgtgtgtatt ttacgaagca 2719081 attcagcaac gggccgtccg ctcatgtctt taggcttcag ctctctgccg gtcatccagt 2719141 gctgggccgt aatgacgtcc ccattttcca tccgttttgt ccaaaccagc ttcggaacaa 2719201 tgccttcggc ggataaaaca gctaaaaaag gtgagctatt acgttttaaa aaaagctgct 2719261 gcccgttatg tttcgcataa tatgcatctc ctgtagctcc tccggcgggg aagatctccc 2719321 aatcgctacc tagtaattgt cccaaccagt tcatatcaat gttcaaccca tcatttctta 2719381 aaatatttta gaattaaggc taatcgtttc tagtctatcc agcgaatgcc tttttcgtac 2719441 gaatcgtata aaaataaaaa agacagctat tgagagtctc atatgctaat caatagccgt 2719501 cctttaaatt ttagcgctat agcacaaact tcgtcaagca aaactcttaa gatctgatgc 2719561 taaatataag ataaccgttc cgatgccgtt tactgcaacc gttttcttga tttctgttgg 2719621 gtcttcctga aatcctgatg gatcacataa aagccgataa ggtatgtcgt ttggcagcct 2719681 ccactcgacg gagtctggac tcgcgtgatg gataacaatg atatctttcc attcgtcaac 2719741 ctcgtcaaga tcataaagcc tgtatgcgat aaggtgttct tttagcgtca agcattcaag 2719801 atggcgctgg atgtctgcag cggacctaag acggaatgca ggatgcgctt ttctcagcga 2719861 gatcagcctg cggatatagt gaacatcttc tttgaatgtt tcacggcgat cccagtcgag 2719921 ctggttgatg ctgtcactgg attgatagct gttttccact ccctgcttcg tccggaaaaa 2719981 ttcctggccg ctgtgaataa acggcacccc ttgggcaagc aaaataatcg cggctgcaag 2720041 cctttgcctg cttcgctttc ggctgtcatt ttcttgagga agcgcaaagc tcattttatc 2720101 ccaaaaggtg tgattgtcgt gtgattcgac ataattgatg gactggcttg gttccggaac 2720161 aatcggtgct aatgccttcc atccggaaga cccggcaatt ccatgcatca cagcttgtgc 2720221 tgattcaccg ttgccgagcg caaaccctgt tgccttaagg tgaaaggtgt tcccttttac 2720281 agcgtcacga aacatatcat taaaaaagcc gatgcccggc attcttggcg cgttcgccaa 2720341 agcagctttc tgttcatgcg gcagcggtgt agccaggtcc cacccttctc caaaaagcag 2720401 gattccgggc tttgccttag ttgctttctc tttcatataa agcacggtgt caatatctaa 2720461 aatcccgagg agatcaaagc ggaagccgtc aacattgtat tcttcaagcc aatagaccac 2720521 gcaatccgca atgaattttc ttgccatcct tctttctgat gcaatatcat tgccaacgcc 2720581 ggtgccgttt gatggcatcc cacattcgtc gtgccggaaa aaataaccgg gcactgtctt 2720641 ttcaaagggg gaattctccc tcttatacac atggttaaaa acaacatcca gaatgactcg 2720701 cagaccgtgc tgatgcaggg tattgatcat ttgtttcagc tctgtttttc tcgtttgagg 2720761 atcatgagga tttgaggcat agcttccctc cggggcaaag aaatgaagcg ggttatatcc 2720821 ccaattgtat gcatcaagcg gcttctcttc atcaactccg gcaaaatcat tcaccggcag 2720881 aagctccaca tgtgtcacac caagctcttt tacatacgct aatcccgaag aactgccatt 2720941 tgcggtttgt gtatcagttt ccgtcagcgc taagtatttt cccttgttta tcatgccgct 2721001 gttttcatgg atggagaagt cgcgaagatg cgtctcatag atgacggcat ccacagggtg 2721061 tgagaatggt ttaagaggag cagtccattt catttgatcc gggcgcaaga cgacgccctt 2721121 ctctccattt acagtcacag ccttggcata ctggtcaact gtttccatcc attctgaatt 2721181 gttgcagatg caaaacaaat actcatatcc gtgaaggtca cctgtgaccg tgacggcata 2721241 gacgcctttt tccaagcgag tcatttggaa tgtgcgcccg cttttattgg ggtgtgaaag 2721301 cttgacagca gctgaggttg cagcaggcgc ccatacttta aatacggtat gatccgcggt 2721361 ataaacggcg cccagctctc cgtcataata aaattcgtca tcaaacgctg ccgtccggat 2721421 gaccgcgcca atttggagat ccgttttgtg gccgctggat gctctgacgc aatggatttt 2721481 tccaaatgtc acaggatggt cggatacgca gacgtacttg tattttgctt caagggagta 2721541 ttcctccctg acagccagag gaaaatctgt tatttctgtc tcaagccgaa acggcggtgt 2721601 catgatttcc ttttgttcag caggaatcag aacagtaatg atattcatgt catcgacata 2721661 cgcttcgaag ctgcggcgga tgctgaccat cggaagctct ctcctccaaa cacgtttatg 2721721 ttttgattct taggggtgaa ggactagatg ccagacgaaa cggggtagtg cccatgattt 2721781 ctccgtcagc atggaacggg attttgtcct tcgtgtaaaa tgtaatgtcc ttcgctttaa 2721841 acatcgtaac gccatccatc tttgtatgtt ttccaaatgc catgagacat aaaagccaat 2721901 attttttcaa aaacggctgg ttttcaacga ttacgatatc aaatgtcttc tcgcgcggat 2721961 ttgctagggg cgccgccttc atgcctcccc cgtaaaacgg atggttggat acaacggcaa 2722021 accagacatc atgaaattcg cgcgtctcgt cttccgtcgt acaagctaat gtaaacggct 2722081 taaaggttgc cgaagcgtgc aaatgagaaa gcggatacac aagaaatcga aggcggagaa 2722141 aaagaaaaac ccgtctcaac ggaaattcca tcgccttttt attgacatat gcgtcaaacc 2722201 cgatcccgat atgattcata aaataaagaa tctgtgattt atcctgaagg aaattgacgc 2722261 tccctaaatg aaaggttctt gttaacgggc gctttacctt cttgatttcc tgtatcagat 2722321 cgattttttt aatagagaac cctcgcgaaa aatcattata cgcgcccgcc ggcacaaagc 2722381 tcagctcaat atcgtcaaca tctttcagcc cgttgacaac ttcatgcatg gttccgtctc 2722441 cgccaatgac gatcaggcgc ttcagcttat attcctgtat cgttgaaatc tgtctggcga 2722501 gcacctcggc gtgtcccgga tgttcagtta aaaatgaacg gtgctcaacc tttcgtttga 2722561 tcaattcttt ttgaatggac ttccaaacac gcaggccgtt tcgatgtcct gctgtcggat 2722621 taataataaa aaaccaatgg ctcatctttc tcacctgctt atgttatgag aaaaccgctc 2722681 aaatcgttct cttttactcc agccactcct gtctgcgata ggagtcagac atgcagtaag 2722741 acaatagagc ctttgcagcc tttacctgat gatgtttgat cggagcagtg tttttcttct 2722801 gccgctcaat ccattcttcc gcgctccgct tatccgctat ttctaagccg tatggcggct 2722861 ccgggtaatc gatgtacgac gttctgctca gaagcaattt tcgaaccgga atctcagcct 2722921 gtttttcctt tacgatcttt gacacaaccg agtccgtacg aaacaggcta agccctggat 2722981 ttaacactga tgcagtctga gaggctgttt tcttgtccca aaaacgattt ttagacccta 2723041 tgtagacact gtcttcctca gcctctaaaa aagaaacgca ataaatttcc agaggagaaa 2723101 taatcacaat gcttaattca accgccgcct gctgaatttt cagcacaggc ttatacataa 2723161 taaaataaga atcaggcagc tgctgggtca gataacgcaa aatgcggtcc tgcttcactt 2723221 ggtttgagag ttgagatatt tctgaaagag tagagcttgc ccatttgagc tgaaaatcat 2723281 ataaatgcct tttataaaaa gaagcaagcg ccaccctgct cttcgggagc cttacatgaa 2723341 tatcttcttc gtcctcaaac cattggtgtc tctcttcttg tatatcggct tttatctctt 2723401 cttttcttct tttcaatgaa aatttttttc gtttctgcac cggttccggt tcttcagcac 2723461 tggcttgcct ttcttcatgc tggcgctccg ctgcttctac tagtgaaagc cagcgctctt 2723521 ttttcaaacg tacaaactgg ttgatataat ggtacggatc aagctcatat ctcgatatat 2723581 aatcatgaat tttgatgatt tgtgccatgt ttgtttctcc actccgcaat gaattaagat 2723641 aattgaaatt tgaatatttc ctcgtatttt ggtgattggt tcaagtgtat ttgaaagagc 2723701 gaaaatcgtt cagccatcat cgaaacctcg ccgctttcaa acggaacatg agctggaaat 2723761 ccatcttcgc ctgtccattt tcttgccagc gtcatatgag gatgatacgg tcttttttcc 2723821 acttgaaagc cggcctgaag tacagcctgc ttcgtatgtt cccgcagtct atcaagcgtt 2723881 ttgtttttct ttggctccag atgtaaaacg cgcggctttc tgcggtcgcc gaatacatct 2723941 atcttgccaa acttaattga aaatggatca atttctgaag caatctctgc tagcgaacct 2724001 tcaagcttct ttatttgtgt ctcatccgcc gctccgagaa aaattaacgt gatatgatag 2724061 tcaagcgggt gcacccattt ttgaaacgtc aatatcggtt cgtttttcgc agcctggtag 2724121 atcggatttg caattccctc aggtatggga acgccgatga aataatgagg ccgtatatct 2724181 ggcatccgtc tgacactccc ttctttgaca gctattattt tatcaataaa gaggctgtgc 2724241 ggatagagga acagtgtatg aaaacactct cgcacaaacg tttattatgt taggatatta 2724301 tatgacactt gttttattca gaaaggaatg acaatgttga aaatcgttgc aaacacagct 2724361 gatctgatag gagatacacc gctagtgaga ttgaatcggc ttcagccgga aaatgcggca 2724421 caagtctatt taaagcttga atttttcaat ccgagcggca gtgtgaaaga cagagccgct 2724481 tatcaaatga tcatagaagc tgaacaaaac ggtttactca agccgggatc agttattata 2724541 gagccgacaa gcggaaatac cggcatcggg ctcgccatga atgcggcagc acgcggatat 2724601 aaagcaatct tagttatgcc tgatacgatg acgaaggaac ggatcaacct acttaaagct 2724661 tacggtgcag aggttgtatt aactcccgga gaggaaagaa tgccgggcag catcaaaaaa 2724721 gcgaaggagc ttgccgaaca aattccgaac agctatattc caatgcagtt cgataacact 2724781 gctaatcctg atgcgcaccg aaaaacaaca gcgcctgaaa tcgcccgggc aatagaggaa 2724841 atcggaaaac cgctcggcgc ttttgtagcc tcctctggaa cgggcggaac cattaccgga 2724901 acaggtgagg cgctcaaaga gctttttccg gatatcacgg ttcatgttgt tgagccagcg 2724961 ggttcgcctg tattatccgg cggaaaacct ggcgcgcata aacttgtagg aacgagccca 2725021 ggctttatac cgccgatttt aaatgaagac gtttatgatg aaattatcaa aatctctgat 2725081 gaagacgcgt atacgacgac aagacggctt gctgctgaag aaggaattct tgtcggtcct 2725141 tcatcaggcg ctgcctgctt cgcggcaatc gaaacagcga aacgcctctc tcctgacaaa 2725201 gttgtggtct gcatgacagc tgatacagga gaacggtact tatcaactga tttatggtca 2725261 tttatttaaa aaaaggactg gcttcagcag aagccggtcc ttttattttg caagctcgta 2725321 aatggcctga gcatataacg ctgtcgatct cagcaggtca tcaatttcga tatattcatc 2725381 cttttggtgt gcgctgtcag ggcgtccggg gaacagcggg ccgaacgcga caccggcttt 2725441 taaggatctc gcataagtcc ccccgccgat tgagattaaa tcagcttttt tacccagctg 2725501 gccttcataa accttttgca gggttttgac taacggatga tctgcggaca cgtgatgcgg 2725561 cttgctgtct ttgaattctc ccagctcaaa ttcagatgcg ctttcgaatg tatcgcggat 2725621 cactttgctt tctgctgtca caggatagcg gatattgatc ccgagctcgc ctccttgccc 2725681 ttctttatag cgcagtgttc cgacatttaa tgtcagctct ccgctgattt catcctcaca 2725741 gtcgatgtcc agtttttttc ctcttgtatc acctgagaac ttatctgtca caacttgcac 2725801 aaaccgcttt cctgcatcgt caagctcagt ctgctggaga aattcgcaca ataaaatgcc 2725861 ggcattgatc ccattgttcg gttccatcgc atggcaggaa agaccgtaca tacgcaaaat 2725921 gagctgtccg ttctctattg cagcttcccc tttttggtcc gtcgtgcgga gcatgtcttt 2725981 aaatgaagac agaatctctt catttttcgg cccttcaatg acagcttccg cagcgtcggg 2726041 caccatgttt aagcgaaggc ctgattgaaa cgagacaagc actgcctttg gttcagcttg 2726101 atttgggcgg tgcggaataa gtaaagaagc atcgatgatc cctttttccg cattaatgat 2726161 cggaaaatcg gcgtcaggcg caaagcccat tgttggcatt tcttcatgct tgaaataatg 2726221 ctctacgcat ctccaatcac tttcttcatc tgttccgata atcattctga ctcgcttgga 2726281 caggggcaaa ttcatgtctt tcacgatttt cagcgcgtag aatgccgcca ttgtcgggcc 2726341 tttgtcatca atggcgcccc ttgcataaat ccgtccgttg cggatttcag ctgaaaatgg 2726401 atcactcgtc cacccatctc ccggcggcac gacgtcaaca tggcaaagta cgccgataat 2726461 gtcatcgccc tccccccatt caatatgacc tgcgaagccg tcaagatttt ttgttgtaaa 2726521 gccttctttt tctccaagct ccagcaatga agtcaggctg gcatttaccc cttctccaaa 2726581 cggtttaccg ggtccggcgg ttgtttcgtc catgacactg ttgattctca aaaattcctg 2726641 tgtatcacga attaaatcct ctttttttct gatcacttca acttcccagt tcataatgat 2726701 cccctttccg caagaaatga cttgcaaaaa ccaaataaaa cgaataatat taatggtgtt 2726761 ttgttaaaac gttcgtaatt ggaggatact atgtttcatc taaaagagca gcaaacatcc 2726821 ataaagcaag aaatcatagc agggctgacg acctttttca caatggtcta tatcgtcgtg 2726881 gtcaatccgg tcattctggc taacgccggg gttcctttcg accaggtttt caccgcaacg 2726941 attattgcct ccattgtcgg aacgctgtgg atggccctgg cagcaaatta tccgattgct 2727001 attgcgcccg gcatgggctt gaacgcttat ttagcctttc atgtcgtaag cgcaagcgat 2727061 ggcggcatca cgtacgcaac agctttcagc gcagtattta cagcaggggt tctcttcatt 2727121 attctatcgt taacgccttt aagaaaacaa cttatagaag cgattccaaa caatttaaaa 2727181 tacgggatca caacagggat cgggctgttt attgctttta tcggtttgcg tcaagcggga 2727241 attgtggcag ctgatgagtc aaacctggtc actctcggca atctgcattc acctggtgtt 2727301 atcttaacgc tggtcggcct tttgatcagc gtggtcctga tggtgctgaa tgtaagcggc 2727361 gctttattta tcggaatggc agctaccgct ttgatcgcct ttttcaccgg tcagctccat 2727421 ttttcaaagg gatttatgtc gcttcctcat ttgccggaag gattgatgat ctcaaatcca 2727481 tttaccgctt ttggcgatgt cattcatcac ggcctgtacg ctgtcgtctt ttcttttcta 2727541 ttagtcacca tttttgatac gacaggcacg atgatcggag ttgccgagca agccgggctg 2727601 atgaaaaaca acaagctgcc gaacgtgcga aaagcgctgc ttgctgattc aaccgcgacg 2727661 acagtaggag ctgttttcgg cacaagtccg acgactgcat ttatcgagtc ttccgccggt 2727721 gtcgcagccg ggggaagaac ggggcttacg gctttgactg tcgcggtgat gtttgcggct 2727781 tcaatgtttt tcagtccgct tgtcagcgcc ttgtcaggta tagccgccat cacctcgcct 2727841 gctttgatta tcgtcggcag cctgatgatg ggctcagttt ccaatatgaa ctggaaagag 2727901 atggacgagg catttcctgc gtttctcgtc attctagcca tgcctttgac ctcgagcatt 2727961 tctacaggaa tcgcgcttgg ctttatttcg tacccaattg taaaagcggc gcggggaaaa 2728021 tggagagaga ttcatccgct cgtcatcgtt ttcgccattc tgtttttcat ccagctgttt 2728081 attttataag gatagaccaa aaaacccaaa cgtcgccgtt tgggtttttt atgtaaacaa 2728141 taaagagaca gcggccgcta aaaaacaaca ggcggcaaac gcatagtgca ggatgttgat 2728201 acagcttttt ctggcccgat aatattcatc actttcctta tcggtgccaa ttaaaaaagg 2728261 ggcatccatg accttgtcaa aaataagcgt caggatataa cggcaaaccc ctgtgtatac 2728321 cagcagcgca atcaccttca gccaaattgg ggaaacaaat atgagaacag tgaaagctga 2728381 cagtagcatg tacatctgcc ttgcatactc gccattcctc agcataactt taaaaaacaa 2728441 ctccttatag cctgtgcaga tcgttcgtct tttaaatatc ctttttgaat ttcggtataa 2728501 taatggtttt cttctcatcc tgtcttttac ttttggcatt cccgcctcct gactcatcat 2728561 catcacaagt cctgcaaggg caagcctgct ttttttctct tcagtcacct cagcttcaaa 2728621 agccgtgaac gaggctgtct ttttcaaact gcggataact gagaaaaaca aaaataaaat 2728681 gccaaaaagc gcaagcaagt gccgctcagt aaaaacaatc aggatagcag aaccagcaaa 2728741 aagaatagct ctgacaaggg tatcgccaat ccatctcgaa atggagcgcg gctttctgat 2728801 cctgtcttgc tttaaggata aaaagaatat atgaaggcca aacaaataac acaatagagc 2728861 agtgctttct gcgaatgtga tgagaacaga atgactgatc aagggaagga caatgaaaaa 2728921 gagaagcagc catttagcca gcgtggccag aaaagaatac aaaagcgcat accgtttgag 2728981 ctgatagatg atttccttct tttgcagcaa aaacactttg tccgcttcca ttaaaaatgt 2729041 acgaatcgaa cctgtaaaca tgatcagcac acacacagca tacagccatc tccattccgc 2729101 cacttcagac cactcataaa gaaggcctct tccgttcatc aaatcaatat actgatagat 2729161 gacaaaagca atcgccggca aaacgatata gagagcgact gtccagtcaa tgaccgcatg 2729221 caacacttta aactgatact tataatagtc aaacagcctt cgaaaaaaga gcgtacgccc 2729281 gttcatagcc gatcaccttg aactgcctta taaaaacagt caagcaatga ctgcccctct 2729341 aatccggtct tgtcctgaac atcttttaac gtgccttgga gaaataatga acctttctca 2729401 atcatataaa accggtcaca gattttttcc gcggtatcga gtacatgcgt gcacataaga 2729461 attccggctc cacgttcttt ttcagcctta agcatgtcca caaagcgttt cgtcgatatc 2729521 ggatcaaggc cgataaacgg ttcatcaatc acatacatat ccggcttaga gagaaaggcc 2729581 tggataagca ttagtttttg ctgcatgccc ttcgaaaagg tgacaggcag ctcatgtttg 2729641 acatgatcta gcgaaaacgt ctgcagcagg ctttgggccc gatgcgcaaa ttcactctct 2729701 tcaatgccgt gaagtgtgct gatcagatcc aaatgctccc acagcgtcag ttcttcgtag 2729761 aaggacggat gctccggaat atatgcaaat gaacagtcgt tccaggcaat atgcccttta 2729821 aaatcttctg aaaggccgag tatcgccttg attgcggtgc tttttcctgc gccgttagct 2729881 ccgatcagtc caaccagttc cccttttctg acttccagaa aaacatcggt gagcactttt 2729941 tttcggcttg tatacccggc ctgttctatt gaagcttcaa gcaaatttgt caaaactcac 2730001 tcacctccaa aatttactac gaaatagaat aaaaaaagtt tctttaacca taataatatt 2730061 gagccgaaat acatagtaat ccaacaagga tggctgccca acgcgaaatt ggaaaaaatt 2730121 aataggagtt atccctagat tcatcactgc aatatcgtgt ataatgaggg cgaattattt 2730181 taacaattac agatgtctgc ctttgttgct atttcgtacg cagttgatag tcgtgagttg 2730241 tggttagtca agtccatccg atcttatgat agggagtggt tttttgaaac cttcaacaaa 2730301 ccgtatgcta actcgaatca aatcagttta catgtttatt caagaaaaag gtcttgtgac 2730361 aacacaggaa ctggttgacg aattcggcat tacacctaga acgattcaaa gagacttaaa 2730421 tgtgttggca tataatgatc ttgttcatag tccaagccgt ggcaagtggg agacaacgag 2730481 aaagaaagta aagattacct cataaattga aaattacata gggccgcctg agagcggtcc 2730541 gatagataac agggcgaaga aactactgag ccttgttttt gtgtgcttat aaataaaacc 2730601 ccgcattcgg tatgcggggt ttttgtcatg cttgcggctc atttagcaaa tgaagctctt 2730661 cctctgtcag ctcacggtat tctccgggtg ccagagcggg atctagggaa acgcgtccca 2730721 tcgaaagccg cttcagataa accacttcat tgccgactgc ctttgccatt tgcttgacct 2730781 gatggtattt tccttctgta attgtcagat atataacggt attgccactg tcgtttgttt 2730841 tgatttccgc ttttgccggc tttgttttat agccgccctc tatgtagaca cccgtttcca 2730901 aatcggaaat gtcttcccga gaaatctgtg attttaaatg gacttcatac gtttttggaa 2730961 catgcttttt aggagaaagg agccgatgtg cgagctggcc gtcatttgtg agcagcaaaa 2731021 agccctctgt atctttatca agcctgccgg ctggaaatgg ctcaaatctc atctcctccg 2731081 gcgtcagcag atcgaccact gtttgctgcc ggctgtcctc agtcgccgac agcacgccct 2731141 gcggtttatt catcataaga taaatgaact ctcgataatc aaccggttcc ccgtatacgg 2731201 tcacctcctg cgtatcagga tcaacgtgct cctttacatc tttggcaggt ttgccgtcga 2731261 tcatcacggc tccagccttc acaacggctt tgacttcttt tctggaacca tacccgctgt 2731321 tggcaagcag cttatcaagt ctcattccca atctctcctt tataaaagaa agcccgcagc 2731381 atgcgagccc tcagtttcat catatctagt tcatcagcct gcatgtctgc ctttcctaaa 2731441 gaaacctggc aaacggcggc ctaaaatttt ctgcaaaaat cctaatcggt agccgcaata 2731501 caggtagaca gctccgccaa cagcggccgc gatcaccaca acaatcgcag cttgcatctg 2731561 gccatcctga taggaaataa agaagcctaa tacccactgc acgattttca cggcaatacc 2731621 cataatggct gataagacca gcatcaaaac agttcgttta acaagtatct tatacgaata 2731681 gcctgcatgg cgcttaatca tgataaaccc atataaaagg gaagcgatat atccaagcgc 2731741 cgtcgctaaa atcgctccgt cagcctgcat cagcttgatc agcggaacat tcagcacaag 2731801 cttgatcacg acaccgatca caaggctgac aaccgcaaat ttttgcttat tgatgccctg 2731861 cagaatagct gcgttgactg taaacaaaga gaacagaatt gcgacaggcg aataccaaag 2731921 caaaatgttt gcccccagtt caggatgaag gctctctgac ccgtaaaaga acgtatacgt 2731981 cggtcctgac aatagagaga tcccgacaac agccggaata attaaaaaca ggatcgtctg 2732041 catcgtttga ttaatctgct gatttaacag cttatagttt ccgcttgtaa acgattcagt 2732101 aatcgttgga attaatgtca gtccaaaagc agttgctagg gaaaccggga tcatcacgag 2732161 cttctgaaca tacagggtta gaatcgcaag catgtcctgg ctgatggctt gatgaccggc 2732221 ttcaatcatc gctttgttaa acgtatttgt atcaatatag ttatacaaag ggatggctag 2732281 tccgacaaaa acgtacggag cagcatagct gaacagctcg aaaaacattt tcttgtagct 2732341 taggtttgct gtcggacccg tattcggcat catcgccagc aggctgccct tccgtttgtt 2732401 ccaataaata taaagcacga ccagccctcc gaaggcaccg atcagcgctg cgaaggttgc 2732461 atagcccaca gcgatgacaa ggccgccgtt gaaaaccttc aaaatcaaga atgtcgcact 2732521 caatagaaag atgatgcgga caatctgttc aacgacttgg gaaacagctg tcggacccat 2732581 catttggtgc ccttgaaaga atccgcggac aaggctcata atcggtacga ccaaaagcgc 2732641 taagctgacc atgcggatga cataaacgac atgatcaatt gtcaggccgt tattatcctt 2732701 gcctcccagc gatatttccg caaacatcgg agccgataga tacagaatga aaaaggctat 2732761 cattcctgtg actagcataa ccgacatgcc cgccttgagc attttcctgc ttgtctcata 2732821 atcccctttt gaattatatt tggaaacaaa tttagaaaca gcggccggaa agcccatcgt 2732881 agcaatattc aaaaataaag tgtattggtt gtatccgtat tgaaataatg caccgcctgt 2732941 cgccccgacc ataatgctga agggaattaa atagaccatc cccagaatcc gcgatatata 2733001 tgtaccgagc gttaatacaa acgtgcctct taacagtttg cttgacatgt ttcttcatca 2733061 ccattttcta cgaagattca acttttctat tttaccacaa ctgggcattt agacggtaat 2733121 aaatacaaaa gcaatcctgt gaacattcat gtccgcggca aaagacgttt aaggagcggc 2733181 tttctttcgc tataatagta ctgcggacgg gtgtccgcac acgaaatgaa aagaaagttg 2733241 atgataaaga tgaaacaata tgacgtaatc gtaatcggcg gaggcccttc aggcttgatg 2733301 gctgcgattg cagcaggaga acagggcgct ggcgtgttgc tgatagataa aggaaataaa 2733361 ttaggacgga aactcgcgat ttccgggggc ggccgctgca atgtgacgaa ccgccttcct 2733421 gtggaagaaa ttatcaagca catccccggc aacgggcgtt ttttatacag cgcgttttct 2733481 gaatttaata atgaggacat tatcaagttt tttgaaaacc tcggcattca attgaaggaa 2733541 gaggatcacg gccggatgtt tcctgtgacc gacaaagccc aaagtgtcgt tgacgcgctg 2733601 ttaaacaggc taaagcagct ccgcgtaaca atcagaacga acgagaaaat taaatctgtt 2733661 ttatatgaag atggacaggc agcagggatt gtgacgaata atggcgaaat gatccatagc 2733721 caggcagtca ttattgctgt cggcggtaaa agcgtgcctc ataccggaag cacgggagac 2733781 ggctatgaat gggctgaagc cgcgggccat accataacag agctgtttcc gacagaggtt 2733841 cccgtcactt ctggcgaacc gttcattaag caaaaaacac ttcagggctt atcactaaga 2733901 gatgtagccg tcagtgtgtt aaataaaaaa ggcaaaccga ttatcacaca taaaatggac 2733961 atgctgttta cccatttcgg cctctcagga cctgccattc tcagatgcag ccaatttgtc 2734021 gtaaaagagc tgaaaaaaca gcctcaagtg ccgatcagaa tcgacttgta tccggatatc 2734081 aatgaagaaa cgcttttcca aaagatgtat aaagaactga aggaagcacc gaaaaaaacc 2734141 attaaaaacg tgctgaagcc ttggatgcag gagcgctatc tcctattcct gctcgaaaaa 2734201 aacggcatct ctccgaacgt atcgttttct gagctgccga aggatccttt cagacaattt 2734261 gtaagggact gcaagcagtt tactgtcctc gcaaatggca cactgtcgct tgataaggca 2734321 tttgtcacgg gaggcggggt atctgtaaaa gaaattgacc cgaaaaagat ggcttctaaa 2734381 aaaatggagg ggctttattt ttgcggtgaa attctggata tccacggcta cacaggcgga 2734441 tacaatatta cctccgccct tgtcacaggc aggcttgcag ggctaaatgc cgggcaatac 2734501 gcccgttctt aatcattact ctttaaatct cttgccgcca aactcacatt tgaacattcc 2734561 ccgcattcat gttagggtga gacttgtttt gtttcacctg attgcggggt aattttaaga 2734621 gaggaatgag ctgccatcgt acgaccatac taagcctgcg agcaagatat aggcgtacac 2734681 aaaaaattag agggtgagaa atgttgaaac atatatctag tgtattttgg attgtgattg 2734741 caatcacagc tgcagctgta ttatggggtg ttatttctcc tgacagcctg caaaatgtgt 2734801 ctcaatcggc acaagcattt attaccgatt catttggttg gtattatctt ttagttgtct 2734861 ctttgtttgt cgggttttgt ctctttttga ttttcagccc gatcggaaaa atcaaactcg 2734921 gaaagcctga tgaaaaaccg gaattcgggt tattatcatg gtttgccatg ctgttcagcg 2734981 caggcatggg aatcggctta gtattctacg gtgcggctga accgatcagc cattacgcaa 2735041 ttagctctcc atcaggtgaa acagaaaccc cccaagcctt cagagatgca ctccgctata 2735101 cgtttttcca ctggggtttg cacgcttggg ccatttatgc cattgtggca ttatgcattg 2735161 cctatttcca attccgcaaa ggcgcacccg ggttaatcag cagcacactg tcaccgattc 2735221 tcggggataa agtaaacgga ccgatcggaa aggccattga ctgtattgca gttttcgcca 2735281 ctgttgtcgg ggtgtcaaca agtcttggtc ttggcgcaac ccaaattaac ggcggtttga 2735341 attacctgtt cggcattccg aatgcgttta tcgtccaatt ggttttaatc attattgtga 2735401 cagtgctctt tttactttct gcgtggagcg gactcggaaa aggaattaag tatttaagca 2735461 acacaaacat ggtattggcc ggattgttaa tgttgtttat gctcgttgtc gggcctacag 2735521 tgctgataat gaactcattt acagattcta tcggacaata cattcaaaat atcgttcaaa 2735581 tgagcttcag actgacaccg aacgatcctg aaaaacgcga atggattaac agctggacga 2735641 ttttctattg ggcatggtgg atttcctggt ctccatttgt cggcattttc atcgcccgtg 2735701 tatccagagg ccggacgatc cgcgaatttt taatcggcgt cttggtgaca ccttgtattt 2735761 tgacatttct atggttctcc attttcggcg tatcagccat ggatctccag caaaaaggcg 2735821 cgttcaatgt agcaaagctg tccactgaaa cgatgctgtt cggaacactt gatcactatc 2735881 cgctgacaat ggtgacatcg atccttgcat tgattctgat cgcagtattc tttatcacgt 2735941 cagctgattc agctacattc gtgctgggca tgcagacgtc gtacggttct ttaaatccgg 2736001 cgaattctgt gaaactcagc tggggtatca ttcagtccgc catggcggct gtgctcctat 2736061 attccggagg gcttgccgct ttgcagaaca cagcgattct ggcagcgctg ccgttttcta 2736121 tcgttatcct gctgatgatt gcctctctct atcaatcgct ctcaaaagaa agaagagaga 2736181 tcaaaaaagc ggagaaactc gataaaccaa gaagtccaag agtgaaaaaa gcatattaac 2736241 aaaaaagatc tttccgcgcc tgcggaaaga tctttttatt tgcgatataa aataagggcg 2736301 gaaaaacagt aaagctgctc gccgtctggg tcgcacgccg ccgaaaccgt atatttgata 2736361 tctatcagct gctcctccga tatccctttt aaaaatgaat tgatttccgt ttgtaagtct 2736421 ttttcatgct cttcatcaaa taccgctacc ttcagcattt tatccgctct cctttctcta 2736481 tcaatctatt ccgtttggaa cagcgttatg atagagaaat gatgattatc tcgtttccgg 2736541 ataaaaagct ttccgtatat gggatttcct ctgtggctcg ccgccgtgct gctccacttt 2736601 cagcagcacg gcataaacaa tgcgcatatg gcagtagctg ataaggctga cgctgaaaaa 2736661 agggacaatg cccggcaggt acgcaagcaa gaaaaagaga gcaacagtca gcgcaagcat 2736721 agtaagcgta tattgcaaat acgccacact gagcaagagc gaaaatttca catacagacg 2736781 ttttttccag tcaaaatgga caagcagcgg aaacacataa aaaagcatgg atacgaacaa 2736841 aaagccaaat atcataatgg cgaagcgcag gatgtgcaga aggaaatgac ttggataaat 2736901 taaggccaaa tcaatataaa tgatcactcc gatgagcgcc agtacagcgc cgagcagatt 2736961 tgaacgaaaa aattcaccct tgtattcctg ccaaaacgtt ttgagcaccg gaacgttgtc 2737021 ctgcccctgg atccacttcc gcatgacagc gaataaagcc gcggtcgcgg gcatgatgcc 2737081 aaacacgccg agaccgagca acgtaaaaaa cagccacagc aagtttgtat acgcaaatct 2737141 cataatccat tcgcaaaaac gcagcatccg tcccagtgag ccatcatgtt ccatggcgcc 2737201 ccctcctttt ttgcattata cattctgcat ctgaaaaagc tctttcatgc cgatcggctt 2737261 cttttcggca accgagcgcc acattccctc accaaccgcg atggagtagg ctccagcttc 2737321 agccccggct aaaatatcat agcggcgcag cgggtctttc cctaaaaaaa gatcctcaag 2737381 caaaagcgga tcacctccgc catgcccccc ttcatttttg accacttgta tcgtctgctt 2737441 tgattcaaaa agcggatagt attcgattgt ctgctcagga aaagcaaacg gaattctgga 2737501 aggttcgtga aattcatttg attcaatacg tccttttgtg ccgttgatcg tcagccggta 2737561 gccttcatac ggggccgaaa aaataatcga gtagcttaac agtgcgccgc catcatattt 2737621 gactgccgcc acgtacgtat cctcgatgtc aatttcctcg tcaaaaatac acgcgtcagg 2737681 cctgtatgca gtatataagc tggactggtc tcctgcttca agatgatcat cctttataga 2737741 agctttagag gaacggggat gccaccttga atagtagtgg catttttctt taacacggca 2737801 cgtcccgcaa aaacgcccgt cttcttccgg caaggggttc cactcactgt ccggcccata 2737861 gtaattcaag gcgccataag caaatacctc ttccggattt tgcccgagcc accaattgac 2737921 gagatcgaag tgatgtgttg atttatggac agaaagaccg ccggaaaact gtctcgacct 2737981 gttccagcgt ttaaaatagc tggcgccatg atacgtatca atataccaat ttaaatcaac 2738041 agaagtgacc ctgcctattt ttccgtccag aatcatttct tttattttcc gatgaaacgg 2738101 gctgtagcga tagttaaacg cgacggtgac ttttccttcg cttttggcct ccgcttcaag 2738161 cacccgattc gcatcctgca ctgttgtcac cattggtttt tcagtaatca catctgtatt 2738221 ccactgaagg ctttttacaa tatatgcgac atgcgtatcg tccctgcctg ccacaatgac 2738281 gatatcaggc tttgagacgc gcatcatctc gtcaaaagca tcttcgctaa actcaggcac 2738341 gtgggccagc tcgggaaatt tcttcttgca aacggcaaaa cgtttcggat cggcatccag 2738401 caatcccgta atctcataat gagttgaaaa ccgctccatc agtggtttga taaacatact 2738461 gaatgctctg ctgctcaatc cgcaaaagac gatgttcttc aatatcctca cctctatcgg 2738521 gcttcagtta gttgagaaat cagctgcagc gcttcctctg ttttttcagc atacacaggg 2738581 ataaacgccg ccatatcgcg attcaattga aaagaatagc cgttcagctg ttttttccct 2738641 ttttcgatct gaacggcata gatcgttttt tctcctgttt ttttattaac agttgtataa 2738701 ggagatgttt tttcaggagg caatccgttt aacggctgaa aattttccgg atcatcgtaa 2738761 gcttgaaaca tgtcttcagg cacgatgaaa acatctccct catgggcggt aatttcagtc 2738821 agcagttttt cctgaaaagc tggaaagata tcgaccttcc cggcattctg ctcggcggcc 2738881 ttttttattt tttcctgtac gccagcctgc atatcagaaa agagaatgac atgcattccg 2738941 tccggcctgc ttgagcatga tgccaaaaag agcactgaga cgatcacaca caaagccgta 2739001 cgtatccttt ttgtcatttc cccgctgacc taaaaagagg ctccagctct gtcatagcta 2739061 aaataaacgc gccggctccg tgcagatcgt ttgtgcttct ttcgcggctg acataatagt 2739121 catagaaacc ggctgacgtt ccgacacata tgtctttgac gagaaacgct ccgtcttctg 2739181 atgtttcggt tttatgctga atcaagcctt gatacgcttt tagcagtgtt gtttcgtaag 2739241 ctctgtctag atagccttta ttgattcctt ttgcgattgc gtacatgtac agacaggatc 2739301 ctgagctttc cagccagtta tcagacctgt ctcccttatc aacgatctgg taccataacc 2739361 ccgtctcttt gtcttgatag cgacagatgc ttttaatcat gtcctgcagc gtgtttttcc 2739421 acacatgacg gttcggatgc ttcttcggca gctcttcaat catgtcagca agagacatga 2739481 cgtaccagcc gatggaacgt gcccaaaatt ccggtgaaca gcctgtctct tcattggccc 2739541 aaggcatttt tttcgcttca tcccaggcgt gataaaaaag tccggttttt gcatccttcg 2739601 tatgctttct catcaatgac tcctgaagca caacctgatc aaacagctcc gtctcctgct 2739661 tcagattggc atatttcagt gcaaacggcc cccccatgta taagccgtca agccacattt 2739721 ggtaaggata accgtctttg tgccaaaaac cgccctcaga cgtccggttc agtgttccat 2739781 ataagctgcg cagccttttt gccgctttga cataccgttc atccttcgtc tgctcgtata 2739841 atggaaaaag aatgagacct gcttgaatgg cgtccagttc atctcttcta aataatagat 2739901 tgccattatc atcgattaag agatctgcat aagccttcgc atactcaaaa taccgctttt 2739961 ccccggttgc ttcccacagc cgcaatacac cgcataagaa aacaccctga tggtagtgcc 2740021 agcggtttgc aggtggcagc tcctcgactg tgtacgtgtt cataatggtg tttgccaatg 2740081 cctccgcgta cgtaagaggc gattttacag cgattgattg atccattgat cccatccctt 2740141 tcctaataaa ttccttcctc gccaaatttc ttcgccaaac gattcgctag catgaccaaa 2740201 atcagcccga ccgccgcttt aaatacgccg actgctgtac tgtagctgaa ttggccctgt 2740261 ttcagccctg cagtataaac atacgtatca aaaatttccg ccacttccct gttagtcgca 2740321 tttaacagca aatacacatg ctcgaagcca agctccagcg tgtctccgat tttcaaaatc 2740381 agcaaaacga cgataacgct tttaatggcg ggcagcgtaa tatgccacat ttgccgcagc 2740441 cgtcccgctc cgtccatttt cgccgcttca tacagctggg ggtcaaccgc tgtaatggcc 2740501 gccagataaa tgatcgtcga ccagcccgct tccctccaga taacctgcag aatatacagg 2740561 ggccggaacc attcttcgtt cagcagaaaa ttgatttttt caccgccaaa aaacacaatc 2740621 agttcattaa tcaagcctcc gtctaccgtt aaaagcacaa acgaaagcga tacaacaatg 2740681 acccaagaca taaaatgcgg gatataaatc agcgtctgaa caaatttttt aaagagagca 2740741 atccgcactt cgttcaatag aagcgccagc agtatcggca ccgggaaaaa tatggccagg 2740801 ttcaaagcaa ataacacgag cgtgtttttt aacaagagaa aaaatgtagg ctcagtaaac 2740861 agcctgataa aatgcttcag ccccacccac tcactgccca aaatgccgag gaacggctga 2740921 taatcctgaa acgcaatcac aattccccac atcgggacat acttaaaaag caaaaaataa 2740981 atacaccccg gcaaaatcat caagtacaaa tatttttgtt gaatcagctt gattagtaag 2741041 cgctttcttt tttctttttt aaaaatgact gcatcaacag ccggcgcttg cgcttctgct 2741101 gttttcattt tttcctagcc tcctttcacg gattcttgca ttcactgtag cgcagcaggc 2741161 aaaagtccgt ctacaatcat atgatcacat cctgttttat ccctttataa tcaagggttc 2741221 agccggtcca cctgaaaaaa agacaccgat attagaaaat gattattgac aatatctatc 2741281 aatctttgga ttaattgtat taaggtgaag tggatgttat gaaatggggg gttttatgaa 2741341 aagaagccaa tacaagtttt actacaaact gatcacgttt ttctgcctgc tcagcaccat 2741401 tccggttatt ttggtcggat tattttcgta cgagcactct cagaaaacgg ctatttccaa 2741461 cgtttcggag gaaaaattcg acacactcca gcagacccag caaagcatcg agcatatatt 2741521 gaaaaccgtc gatcactctt taacccacta tgtgagttcg ccgcctctcc ttcgcacatt 2741581 gtccgagcct ttgcactcag accaatttca aatctataac caagtgaacc aagagctcaa 2741641 ttatctgcaa agctttgata ccgatctgtc caacatgacg ttagtcagtt atacgaaaaa 2741701 atggtacatg aacaattccg gtttgtaccg tttgaataca gacactcttc atgaagcagc 2741761 ctcagcgtac acgaaacaaa aagcgagccg ctcctattgg acgcttgagg aaaacaatca 2741821 tttgatttca accaaagaag gcacagcaga aaactgccgc tacaatatca atttaattaa 2741881 gcagcttcct ttgaacagca caaatacaaa gggattggcc gccgcaagca tcccgagctg 2741941 ttcgcttgtc aaaaatatgc ccggctattc aaacgccaac aacctgttta tcatcgatga 2742001 aaaaggcctc atcatccttc ataacaatat gtctgacgtt ggtgaatctc ttcataacga 2742061 cggctttgtc caaaaagtgc tggcgcaaac ggccaatagc ggacagtttg aaacagtgat 2742121 tgaccggatt cattataaag tcacctatca aaaatctgac tataatgcat ggacttattt 2742181 ttctctcgtt tccctgcctg agttaaaaaa agaagccaaa tcaatcggct ggatcacttt 2742241 tgcagtatgc ctcattttgt taacgctttc attgctgttc tcttggcttg gctcccgcca 2742301 tttttacaag ccgatcaggg tgctttacga atcattcgca agacatggag ccatacaaga 2742361 gaaacaacag cctcctcaaa atgaatttga gttaattgaa cagagcttta agcagctgaa 2742421 ggacagaaat gacgaccttg aagaaacgat gaagcagcag gccactcatc tgcagcaata 2742481 ttttatggtc aggcttatgc ttggaaaact gacggatgag gaggttgata accgttttga 2742541 aagcctcggc ttaaagcaaa attggcggca ccttgccctg cttgtgctcc aaattgacac 2742601 actgaatcat acgccttatg agaaaaaaga tatggatctg cttttgtttg ccgtcaacag 2742661 cctgattgag cgcaacatcc cgacggacaa acatcttgcc cccgccgtag ttgacaaaca 2742721 gcaggcgacg attttgatca atcaaagcgg gacaaaggaa gaattcatgg ctgagctgaa 2742781 tgagactgca aggatgattc aggaaaaagc ggaagctgag ctgcagctgt ctgtcagcat 2742841 cggcatcagc cagccgtttg atgtgctgac aaaagcgaaa acagcctatg cggaaggctc 2742901 agaagcgttg aaatatcggc tgaaagcgga aaacaagtcg atcatctttt acgaagacct 2742961 tgaccagaaa aaaaccttca aaacccattt tccaaagcag cttcagcatg agctgttcga 2743021 tgctgtcaaa gcaggagaca aggagaaagc ggataaatgc ctgcacgcga ttttacaagc 2743081 cattttcacc cagaacacca acccgtatca atttcaaatc gccatcgccc gttttttgaa 2743141 ccatgtgatt gagctgatgc atgtgcttgg gatcgaattg tttgagcttg aagaaaacaa 2743201 aatgctgtat gaccaaattt ttgagctgaa aacgttcgag gataccgaaa actggctaaa 2743261 gaatgagttt attgatccga tgacagacaa agtgaacgcc cgcgcggatg cccagtacaa 2743321 aaatatttcc gacaacatca ttcatatcat ccatcatgag tttgaatccg aattgacact 2743381 ggacgaaatc gcacgcaggc tgcattacaa cccaaattat ttaagcagta ttttcaaaaa 2743441 agaaatggga atttcattca gcgagtatgt ctcaagctac cgacaccata tggcgaaaag 2743501 ctggcttgcc gaaaccgaca tggcggtcaa ggacattgcc gaaaagctga aatataaaaa 2743561 ctcccaaaac ttcatcagat catttaagaa gctggaaggg attacaccgg gaaactaccg 2743621 ccagcaaaaa agaagcatgt aaaaaaccca aaaccgcttg cgcgttttgg gtttttccaa 2743681 tgttattttg cttgtttaaa cgcttcttcg tattcctgaa taatttgttt tcctccgctt 2743741 gactcccatt tttccacttc tttatcgaac tggctttctg tgatgtctcc aatcatatat 2743801 ttgtaggtcg cgtcatcaat gattttcttc agttcgtcac cccgttccga ctccgatgcg 2743861 gaatacaggc tttcagccgg gtttgagacg ataatctttt cattgtcctc ggtcagctcc 2743921 tcgtacgccg tccgaagcgg atctccagtg ttttttaagt aggctttatc aatggcaatt 2743981 aaagcggaca gcggctgaat atcagtctgc cagtctttta cctggctttc tttgcgtgta 2744041 aacgttttgt cctcaccttt gttgtaatga acgccgtcaa tgccataagt catcaggcta 2744101 tagacatctt cttcggcaat tcggtcaaaa aacgccaaga tccgtttaag ctcagcttcc 2744161 gttttcacac tcgttttcgg gaaagcaaac acgccgttat ggcctcctga tgcccatacc 2744221 cgctctttcc catctgggcc ttttatgcgg ttgatgatct cgagcttcat cgatttatca 2744281 gaggcatggt cgcgcagatt gaccgcatct accatattgc caatataaat tccggctttt 2744341 ccttgagaaa acagctcttg ctgctgggtt ttgcttgtga cgggaaaatc cttattcata 2744401 tacccgttat cacgcagctt tttcatatag ttcatcgtgt ctttgtattc ctgtgtcatg 2744461 aaatcaggcg tgaatttgcc gcccgattcc ttccaatctg tcggcatgcc ttcatacgag 2744521 ccaatcgttt taaacgcgcc gtaaatcaag tcattacggt ctgccagccc gaatgtatca 2744581 tctttcccat ccttgtccgg gtcgtcctcc gtaaatgctt tggccacttc ataaagctca 2744641 tccaacgttt tcggggtttt caaatttaaa ttgtccagcc agtccttccg aatgacgatc 2744701 ccctgtctgg aaagcgggcg ctctctgtat atcccgtaga gcttgccgtc aattgtcaca 2744761 tttttattaa tgagtttgtt cattttgttt aagttgggat aatccttgat ataatcgccg 2744821 atttcccaaa acattcctga ccgaaaggca ttcatgactg acgaattttt aatatcctgg 2744881 atggtcacga tttgcggaag attgccggct gcaagcgctg cattcagcct gtcttctttc 2744941 accgcgtctg gaacccaggt gatgtcgagt tctgtatttg tcagcttttc aatttcttta 2745001 atcgccctgt ctttcggcgg ctgctggtga tacaaaatcg ccatccaaga cagctttacc 2745061 tttgaatctg ggccagcttt gccttcagcc gaagactgat cagttccttt acagcccgcc 2745121 agcactccgc cgagtgccag tacaagcaca atcaaaagca ccctccattt gtttcccatc 2745181 gtacccctcc gtttcatatt tctttatcct ttgacagatc ccagcaaagc tccttttgca 2745241 aaatgctttt gtataaacgg atagacaagc agaacaggga tggtcgccac cactatgacc 2745301 gccattttaa tggtttgctc aggcggcggg ctgcccgacc ccatttcaga catatccccc 2745361 tgcataccgc ttgatacaat gacgatttgg cgcagaagca cctgaattgg ccattttgct 2745421 gaatcattta agtacaagat cgctgtcata tacgtgttcc aatacgtgac cgcataaaat 2745481 agtgaaatcg ttgcgatcgc aggaagagac agcggcagca caattttaaa gaatatgccc 2745541 agatcattgc acccgtcaat tttcgcggac tcttccaggc ttgacgggat attttgaaag 2745601 aagtttttca gaatgatcag gttaaaggca ttaatggctg tcggcaaaat aagcgcccag 2745661 taagaatcga gcaatccaag cgatttgacc acaaggaaag tcggaatcat gccgccgcta 2745721 aacagcatcg taaatacgac gagaaacatg agcggctgcc ggccgattaa atcacggcgg 2745781 gataacccgt aagccatcag tgacgaaaga aacatgctga ccgcagtgcc tatcactgtc 2745841 acaaacacag aaacaagcaa actcttataa ataatatctg ttgaaaaaat gtagcgataa 2745901 gcatctagcg aaaaagtggt cggtattaaa ataaattttt tcgacacgac ttcttctact 2745961 gtggcaaagg atgctgcgat aacatgaatg aacggaagta cgcatattaa agcgaacatc 2746021 agcaagaaac cataaatcaa catatcaaac agacggtttt tcagtgaatg tgcgatagct 2746081 cccacctccc tttgtaagcg ttatcatatt tttggaaacc gagctcagca tgtgacgata 2746141 tcgtgtctaa aatgtagcaa atctgtgatt gccatgtcta taatcatttg aacagtgtcc 2746201 ccggccgggc gggggctgcc gcgaattgag accgataaca aaagaaaaag agcataatct 2746261 tagaaaatga ttatgctccg ttctcctcct cgttcagaag ttcagccgta ttgatttgtg 2746321 gcgaaaaccc aagttcattc acggcagatt caatggacca tggccggccc ggattatcag 2746381 agacggcgta ataagtgcca taccggatgt tggtctcaat ggcggctttg aaaatcgaca 2746441 gcagatcggg gtgagaaagc agtgtctttt tcgtccgttc tttttcatgc agcgtatcca 2746501 tttcatctgt cacgactgtt ccgattcgaa ggttgattac tgatagctta ttttccaaat 2746561 aaaacaaatg gccgatctgt tcagaggtca gctttaatac accgtacaag ttttttgaca 2746621 gcggataatc gcttgttgtg atttcccgtc ctaagagcga gcgcccgtct ttttcatata 2746681 catctgtgac atgattgctg ctggcgaaca cgagcttttg aatgccgagc tccgctgccg 2746741 cacggcacag ataatagctt gccctataga aaacatccgt cattttttca aactcagcga 2746801 tgtccataat atcgtatttg attttcacag cgagtaaatt caagatggca tcggtatctt 2746861 ttggaatctt cttcaacagc tcctcataat ttgccgcgtc agcctgaatg gaagaggctt 2746921 tgccatcgaa atgatcttta tcaagcacag tcacttcata gtctgaaata agcccttcag 2746981 caagcagtct cccaatcaca ccatttccgc cggcgatcag cacttttttc acgatgttca 2747041 ctcccctttt ttatagattg cccattttcg gcggggctga cacttttttg gcactcacat 2747101 tcttaggctt attcaaaagt caccggcagc tcctcaagcg cccgaaatcc aaaaagcggc 2747161 cgataccgcc attcaaaatc cgcaagatta aggctgggca ttcgctgcag aagagtgtta 2747221 atcgcaattt gcgcttctaa tcgtgccagc gaggacccta agcaaacatg atggccatgc 2747281 ccgaatgaaa gatgcggatt aggacttctc gtaatatcga agacatcggg gttcgtgaat 2747341 atgctagggt ctcgattagc cgctcctaac aaaagataga cttgttctcc ttgacggatc 2747401 gtcaccccgc agatgtcaat atcctctgac gcaactctgg ctgtcatttg cgtggggctt 2747461 tcatagcgta aacattcctc gactgcggta ccaataagat ctggattttc tctcagtttc 2747521 aaaagctgtt ctggatgctg cagcagacaa aggactgaat tgctgatgag attgaccgtt 2747581 gtctcatgtc cggcgatcgc cagcaatatg cacgtagatg ccgcctcctc ttccgtcagc 2747641 ttatcctttt ctctcccctt caagagcatg ctgatcatat cctgttgagg gtggcgtttt 2747701 ctcttttgaa tcagctcttt gaaatatgcc atagcctgca cagccataat attgccctct 2747761 gttaatgcct ttcttgagcg ggtaaaatca atcgtttgaa tgagactcgc agcccactcc 2747821 tttaattgct ccctatcttc ctccggtaca cctataatgt tagctatgac aaaacttgct 2747881 aaaggaaaag caaagtccga aatgacctcc atcttttttt taccttgcac ttgatcaagc 2747941 aaatgatgga cagtttcaat gatatacggc tgataactct ctgtcgttct cggcgtaaac 2748001 gctccgctgg caagcgtccg caatcgtcta tgatcaggct ggttctgaaa cagcatcatt 2748061 tgattttgca catgtgaaag gtcctgatat ttggttgagc tctcaggcag cggggtgcgg 2748121 actttgaatc tcgcatcttt caaaatagca gccgtttctt catatcctgt gacataccag 2748181 cccgggtatt ttaagaaact ccctttatag ataggatgaa cagctcgcaa tgtgtcgtaa 2748241 aaagaatatg ggtttttcaa aaactcagaa gatgcagttg acgatgcaat tgtcacgtga 2748301 ttttctcctt tctgttcaaa aataaaaaca atcgacatca taccgattgc ttttattgat 2748361 tctttcagct tttcgcactt aaactagcct tcatttcttc gactgattca acttcaaagc 2748421 ctaaatcact cagcatttta tgatcctccg tctcctcttg cccggcagtt gttaagtagt 2748481 ctccgacaaa aatggagttt gcggcgtaaa gccctaatgg ctgcaatgtg cggagattga 2748541 cctctcttcc tccggaaatg cgaatttctt ttgatggatt gataaaacgg aacagcgcca 2748601 gcacttttaa acaatacagc gggtttaatt cgttgacgcc ttctaacggc gtgccatcaa 2748661 ttgcatgcaa aaaattcaca ggaatggaat ccgcgtcaag agccttcaag cttttggcga 2748721 tgtcaatgac atcctgtttc gtctccttca tcccgataat ggcgcctgaa cacggagaca 2748781 gccccgattc ttttgcgatt tcaaccgtat tgactctgtc atcgtatgta tgtgaggttg 2748841 tgatgtttga atggtttctc tgtgacgtat tcaaattatg attatagcgg tctactcctg 2748901 catctttgag ccgcttcgcc tgctctggct tcaacagtcc aagacatgca caaatcttca 2748961 gtccatacgt ctctttaatt tcctgaaccg catctacgac ctgatccact tctctgttag 2749021 acggacctct gccgcttgcc acgatacaat atgtgccgat attcagatcg tgcgcccgct 2749081 tcgcgccttc aagcagcgtt tccttattca ccatccggta agactcaatc ggcgctttcg 2749141 aaatcgcaga ctgtgaacaa tagccgcagt tttccgggca gagcccggat ttcgcattca 2749201 taatcatatt gagctttact ttttttccgt aaaagtgttt tctgatgtga aaagccccgt 2749261 gcattaatag caaaatatct tcatcaggac aatgtaatat tgaaagcgcc tcttcgtcag 2749321 tcacttctgc tccagccagc acccggtctg cgagttccat ccattgattc attctcatac 2749381 ccccacttga ttcatcagta atgatagatt gatatggtct tttaccatat gtagaaccgt 2749441 ttctttcgtc acgttggcaa gctttggcgt aacccctaaa atcggcacac cgcataagcg 2749501 ctcaatcatc tcaggattgg ttttttcatc ttcatcagga gagtcactga ttccattgat 2749561 gataattccg gcgattggaa gccccatgct ttctgcatat ttgacagtta aaaaggtatg 2749621 attaatggtt ccaaggcgag gacgcgccac aataatcatg ggaagctgca acgcttttat 2749681 gacatgactg accaaatagt cctctcccaa tggcacagaa ataccgcctg caccttctac 2749741 gatgaagcat tcatgttttt ctctaatccg cccccaatgg cttaaaacct cttccatggt 2749801 gacagtcttt ccctcaagtt tccctgcaac gtatggtgca agcggcgcct tgaaggcaaa 2749861 aggcgtaatg tcttcatgag aaagactggt ctgcgacata tctttcagca aacttgtatc 2749921 actatctgga tgatggcgcg atatcccgct taaaaatggt ttatacaccc cgacatgtct 2749981 attattgtct ttcaataagg cagcaagacc gctggatata accgttttcc ctacttctgt 2750041 atcagttccc gtcacaaaaa aacccctcaa atgatgtgca gctcctttcc gattgaatga 2750101 aatgtttgca gcaaatgatc aatatcaccc atactgtggt cagacgtgat tgtaattcga 2750161 atccggcttt cacccggcgc aacggttggc ggccgaatgg caggagcata aattcccttg 2750221 ccctgcagtt tttcagcaaa taggaccgtt ttatgggcat cgccaatgac tacaggaata 2750281 atcggtgtgt gatctccttt caccacataa cccatattct tcagactggt tctgatcatg 2750341 ctgatataag aaaataaaag ctgtcgtttt tccctgctgg cttcaatgat gttgaaagcc 2750401 tcgtgagcag ccgcacagct ggctggcgga atagcggttt gaaagataaa tgttctggca 2750461 tggttcagca aaaagtcgat gaagaccgct gatcctgccg caaaacctcc ttccgcgcca 2750521 acagctttgc ttaaggtgcc gataacaatg tcgggacaaa caccaaagta ttcactcgtt 2750581 ccttgtcccg aatcgcccaa aactcctgtt gcgtgggcat catcaacgac cacgaaggca 2750641 tgatagcgtt tcgcaagtga gatgatctga tcaagagggg cgattgtgcc atccatgctg 2750701 aatactccgt ctgttacgat aaaacggcgc tgataacgct gtgtttcatt cagcttgttt 2750761 tcaagatcat tcatatcaat atgccgataa acaactgtat cagccttaga aagtcggcag 2750821 ccgtcgatca tacttgcatg attgagctgg tcacttaaaa tgacatcttc cttttctggc 2750881 aaggatgaaa ggacaccgac attggccaag taaccgctcg aaaacagcag ggccgcttct 2750941 gtcagtttaa agctggcaat cttcttttct agcttttcat gccagaccga attgcctgtc 2751001 gttaaacgtg aaccgctgct tcctgtccca aattgctgca atgctgtttg ggctgcatcg 2751061 atcaaacgtc tatcgcttgc gagccctaaa taattgtttg aggaccagac cgtttgattt 2751121 tcgccatcaa tattcctctc tggaaccggc gctccatcca ttgaccgcag gttacgatgt 2751181 acgccggctt ctttcattct gtctaaccgc tcgtttaacc aggaatcaat cttcaaggct 2751241 cgtaacctcg tggatcgctt gtttcataat ggcaaccatt tccgagagct cttcagctgt 2751301 gctggcaaga ggaggaagaa atgcaatcac gtccccaagc ggtcttgtca gcattcctaa 2751361 ctctctcatt tttaaggaaa ctttgtatcc aatccgccga tcagccgggt aaggttcttt 2751421 agtttccttt gatcgtacaa gctctgcacc gcacataaag ccaagctgcc gaatatcccc 2751481 aacatgagga agagcgtgca gatcttgaag aagaaaatgg agctttttac ttttttccgc 2751541 tacttgttcc acaatgtttt cagattcaaa taatgccaga ttttcaagcg caaccgcaca 2751601 gccaagctga ttgcctgtat aggaatggcc atggaaaaag gtttttaggt tttcataatc 2751661 atcatagaat gccttataga tgtcttcagt ggcaaacgta acggcaattg gcaaatagcc 2751721 tcctgtaatg cctttaccgg cagccatcag atcaggctgg acattctcgt gctcgcacgc 2751781 aaacattttt cctgtacggc caaagcctgt agcgacttca tcaacgatca ttaagacatc 2751841 gtatgttgta catagctcgc gcacgcctgc caaatatcct tccggcatca cgatcatacc 2751901 ggacgcgcct tgtaccattg attcaatgga aagcgcggca atttcctcat gatgttcctc 2751961 aagcagctgt gcaagctctc ggaggcactg atcacggcac tcatcaggat caccgctttc 2752021 agaacgatac acataaggaa tcggggcctt gtaactctcg aacatcaacg ggccgtatac 2752081 gtggtgaaaa agctcaattg aaccgacact gacggcgcca atcgtatcac cgtgataccc 2752141 gtttttcatt gcgatgaatt tttgtttctc gggcttcccg atgttcttcc aatactgaaa 2752201 cgccattttt agggctattt ccatcgcctc tgcgccgctg tctgaataaa agacccgcgt 2752261 gagctttttt gggctgatgt cgattaatgt ttcggcaagc tgggttgctg gaacattggt 2752321 catgcccaat aacgtggagt gcgcaatttt tccgagctgt ttttttatgg cgtcatctag 2752381 ttcttttttg cggtgtccgt ggacattaag ccaaaccgat gaaaaaccgt catagtattc 2752441 cttgccgttt atgtctttga ctttgattcc agtcccgctt tcgatgatta aggggttttc 2752501 atcataatct ttcatttggg taaatggcag ccagaggtgc tttttacttt tttctatcaa 2752561 atcatgagtc atgatcttcc tcccactcta ttaaaatagg ctgcttctcc aggtcatgta 2752621 tgtacgtgtt tacatcattg gatccatcaa taaaaaagac tcggcagccc tcttcagtcc 2752681 cgtattcttt cattgctgta atacgctgat agcccatttt cttacccgca acatagcctg 2752741 ttatgtaatc cggatcgtcc gaccagcata attctgcaac gactgccggg tgccggctta 2752801 cctttgaagc gagcgcaagg gcctctttta ttcttgaatg agctggcacg tgactgtgaa 2752861 gcgcccattt ttcaaaatta gcgtccggcc aatccattct ggagacccgc accccttttt 2752921 cttttgtttg atccattcgc ttgcctgtat gaatatcaaa caacaccgca cccctgacat 2752981 ctgaccattc agggatttgt tcatatgctt tttcaatcac gtctcgtgaa acgccttctt 2753041 tttccaataa caatcgggca agcttttgtc cttcttccgg gcagctcact tcattcgtat 2753101 gcacaggcaa tggctgaatg gtttttatcg attcatgtac ctcttcaaat tgaatttgca 2753161 taaaatcagg ttttcctctt gaatgggata accctttttc taataaagca ttgactgtat 2753221 gcttcatctc atggaaagga ataagccgtt ctccgccgga tatatgcttt ccgccgtctt 2753281 catgagatcc attcattgaa gccctcattc tgacactata aaaagtttct tcttgcatca 2753341 tttctcgccc tttcactgat aactgaagaa cgtgtagcgc ttctcaccta aattgttaac 2753401 caattatatt caaaggttaa caattagaat atattattct ctcctgtttc tgtcaataga 2753461 agaaaggatc gatttatggc agttggttaa aaggaaacaa aaagaccgtt ttcacacaaa 2753521 acggtctttt tcgatttctt tttacagtca cagccacttt tgcaaaaacc ggacagcttc 2753581 atgccttata actgctgttt cgaaatgtcc cgaagcagaa cggaccactc ggtagcaatc 2753641 agcagctccc tgtccagcat agacagctgt caattctttt tcgattttgt ccacgccctc 2753701 agccggcgtt aaccgatcgt gtacaccaac aagactaagg tgcgggcgcg gcgcgatcag 2753761 gctttggatc tccgatgcgg aaaaatgctt tgcaagcgat gggacgtaat aataaaagcc 2753821 gtgcctgtca agattctgtg ttttgatcag cacgtgatga tccacctggc tgcacaaatc 2753881 cacacacacc ttaatccggt catcgagcgc cgctgtccac cacgccatca aacctcccat 2753941 agacatgccg atggttccga tcctgtcagg ctgaacatca gagcgtgact gcatatagtc 2754001 taacgcactt aaactgtcat aaatcatcat cccccacatc acttttccgg tgagaagcat 2754061 ttctttaaat atctcgcttt ccgcttttcc ccgccgatct ccaaaccccc aatgatcaat 2754121 cgcaagaacg ccgtatccga gtgaagtaag ctcatcagaa aaagaaggcg ttttcaaata 2754181 atccgctccc tcaatcagct cactttttcc cctatcatac tggcctccat gcgaatgctg 2754241 aaacaatacg gctgggcacg gtccttctgt tttcttcggc ttcacaaaat aagcgggcgc 2754301 cttttcatgt ccatttaaat cgagcaggag cgtttcaacg atattttctt ctctttcttc 2754361 aatacgtaat gtctcaacac tgattggcct ccgatcaggc aaatcaccaa gcaatcgaaa 2754421 cagttgcttt cttctttcgg ctctcatccc atcacccttc cttattcgct tacttcacat 2754481 ttacgagaca gatctgggtt cccctttatt tttccaacat aaatcacatc atttactaaa 2754541 tatttagtaa atattatgga atatttcgaa aacaattatt gtaaccgctt acttttatat 2754601 gataatatca atttatcaaa aacagatgag ttaatatttt actaaataga tgagagggat 2754661 acccatggtt cgtattaaag atatcgcctt gaaagctaaa gtttccagcg caactgtgtc 2754721 cagaatttta aatgaagatg agtcgctttc tgttgcgggc gaaacgagac aaagagtcat 2754781 caacatcgct gaagagcttg gttatcaaac cgttgccaaa cgccgaaaat cccgcgggca 2754841 aaaacagcgg gctcagccgc tgatcggtgt gctgagctgt ctgtcccctg atcaggaaag 2754901 gcaggaccct tatttttctt ccattcggaa agggattgaa aaggaatgct ttgaacagga 2754961 aattttcatt acaaattcga ttcatctcgg ctcctttcag gaacatatct ttcgggaatt 2755021 ggatggtgtc attgtcatcg gccgtgttca tgatgaagcg gttaagcata tcagcgggag 2755081 gctggagcat gccgtattta tcaatcattc accagatccg caagcatacg attcgattgg 2755141 catcgatttt gaatcggctt cacgccaggc gattgatcac cttttcgact taggctacaa 2755201 acggttaggc tacattggcg gacaagaaaa agagcatacg ctgaaggacg gccaaagcat 2755261 tcgcagaacg attgaagata aacgcctgac cgcttttttg gagtcagccg ccccccagcc 2755321 tgagcatgtg ctgatcggag aatacagcat gcgtgagggc tatcgcctga tgaagaaagc 2755381 aatcgatcaa ggccatctgc cggaagcatt ctttattgcc agcgattcta tggcgatcgg 2755441 cgcattaaaa gcgctgcagg aagccggact gcaagtgccg cgggataccg caatcgtcag 2755501 ctttaacggc attgaggaag ctgaatttgc cagcacgcct ttaacgacgg tgaaggtata 2755561 cacagaggaa atgggccgga caggcgtaaa actgctgctt gaccgtctca atggccgaac 2755621 gcttcctcaa catgtcaccc tgcctacaac attaatcgta agacaaagct gcggatgtac 2755681 agcaaaggag gtgacataag caaagattca tcacgatgat aaggaggaaa agatgaaaca 2755741 cacttttgtt ttatttctct ctcttattct gcttgttctg cccgggtgtt cagcagagaa 2755801 aagctcagca gataccgcaa aaaagacgtt aaccatttat tctacaatgt caaccgacag 2755861 tgaaagagat acgttcagaa aactagcggc agcattcgaa aaggaacaca gtgacattca 2755921 tgtcagcctt catttcccag gcaatgacta tgaaaatatg atgcgtgtca gaatggcggc 2755981 caatgatttg ccagatctat tcgatacaca tggctggggg aaaatcaggt acggagaata 2756041 tacagcggat ctccgggata tgaaatggac tcaagatctt gatcccaatt taaacagcat 2756101 cctcaaaaat aaaagcggaa aggtgtatgc ctatccaatc aatcaggcaa aagacggtct 2756161 ggcgtataat cgcaatattt tagaccgtta cggcattgct ccgccggaaa ccatggatga 2756221 ctttatcaaa gcactgagaa cgattaaaga aaagagcaag ggaagcattg ttcccttctg 2756281 gtttgccgga tatgacaaaa gctcattcgc ccaatattac gaccaattcg ctacacctct 2756341 tctcatcaca gaccctgccc ataatgaaaa aaaacagctc atcaacggca cttttcaatg 2756401 gagtaaattc acttatttat cagaaatcct caaacaaatg cagaaagaaa aattgatcaa 2756461 tatcgacgcc gtcacggcaa aaaaatcaca gctcattgaa ttaatggccc aaaacaaaat 2756521 cgcctttaca atgcaaggcg gcacactcgg ccaagacgtt gcccagatca acccgaacgt 2756581 caaggtcggc attatcccga cacctgccat ccatcccggt gatgacccga tatggatcgg 2756641 cggtgaacgc tacacccttg cagcatggaa agattcgcct caattaaaag aggcaaaaga 2756701 ttttatcgca tttatggccc gcccggccaa tgccaaacaa atggctgaag ccacatcgct 2756761 tccttcaggg ctgaccaatg tgaaagctga tattttctac gcaaacgatt atgagtatta 2756821 tcaagatgtc aaagtcgagc cttacttcga ccggttatac ttgccaaacg gaatgtggga 2756881 tgtcctgggc acggttgggc aggagctcgc ggctgacatt ttggcgcctc aagacatttc 2756941 gcagaagctg ggaagagaat ataaacgact ccgggagcaa tccgaaacac agggagctga 2757001 aaacaatgag tgagatcgca agggacgttc atgtgaaaca ggttaagcca aaaaagcagt 2757061 cctcactttg gtggatgtac attcctgctt tgctctccgt tctggtcttt atgatttacc 2757121 cgtttgtgaa aggcacattg attaccttta caaactggaa cggattttca caagtctacc 2757181 aatgggttgg attcgcgcaa tatgaaaggc tgttttctga tcctgatact tggcatatct 2757241 taaaaaacac gctgcattac gggcttggca gcaccttttt tcaaaatgtg gtcgggcttc 2757301 tgtacgctct cctcttaaat caaagcatta aaacgaaagc ggtaacaaga acaattgtgt 2757361 atttgccggt gatgatcagc ccgctcatta tgggctacat ttggtacttt ttcttctcct 2757421 atgacggagg cgcgctcaac gatttgctcg gggtcttcgg catcagccct attaatgcgc 2757481 tcgccagtcc ctcgctcaat ccatggatca ttgtcatgat taacacctat caatatgtcg 2757541 ggatcgctat ggttgtctac ttagccggtc tgcaaagcat tccgaaagac tactatgaag 2757601 cggcgcaaat ggatggcgcg aaacaaggcc agcagttttt taccatcacg ctgccgctgt 2757661 taatgccctc cattaccatt aatatagtca tcaacattat cggaggctta aagctgtttg 2757721 acgtcatcat tgcactcacc gcaggcggcc ccggaaatgc gtcacaatcc atgtccacgt 2757781 ttatgtatga tttgtatttc aaacggcagg atgccggcta tgccgcaacg caaggcatat 2757841 ttatggcatt tgtcattttg atcatcagct tttgcgcgct tgcgtacttt aaaagaaagg 2757901 agacggaaat gtcatgagag ccgcccgtac aaaaagcatg cggatcatta cgcttcttgc 2757961 agccattgtg gcctgtgcgc attttattcc tttttatatc ctgctgacca cttcattgaa 2758021 agcaaaagga gactacagtt cgaaatggat atttccagcc gacatctcct ttcataattt 2758081 ttcagaggcg tgggagcgcg cttcgctagg aaactctttt ataaacacca tgatcatcac 2758141 aggtttttct gccttgttat taattatatt cggctcactt gccgcctacc cgcttgcccg 2758201 gcgggaaacg aaactgaata aagccgtttt tgccttgctg atttccatta tgatcatccc 2758261 tccgttaacg tccatggttc ctttgtaccg aatggtcgtg gacgccggaa tggtcaatac 2758321 acacgcaatc gccattttca tcaatacagc ggcttacatg ccgttaaccg tattcttata 2758381 ttcaggcttt atccgatcga ccattccaaa agagcttgta gaagccgcaa gaattgacgg 2758441 tgcaggcatg ctgaaaatct tttttacgat tgtgtttcct ctgctgaagc cgatcactgc 2758501 gaccatctgt atcatttctt gtgtctttat ttggaacgac tatcaatttg ccattttctt 2758561 tttacaagat caaaaggttc agacattaac agtagccatg gcaggttttt tcggagaaaa 2758621 cgcaaacaac cttcatttag ttgccgcagc ggcacttatg gcaatgctgc cgatggttgt 2758681 tctgtttttg gcgctgcaaa aatactttat tgccggcctg tcttccggag cggtaaaggg 2758741 ttaacattaa agggggaagc aatatgaaaa agattacatt tatcggtgca gggagcacga 2758801 ttttcgccaa aaatgttttg ggagactgcc tgttaacaga ggcactgaat ggatttgagt 2758861 tcgctcttta cgacattgat cccaaacgcc tgcaggaatc ccagctcatg ctcgaaaatc 2758921 taagagaccg ttataaccca agtgtggcca tcaacagcta tgatgacaga aaactcgcct 2758981 tgcaaaacgc aggctatgtc atcaatgcga ttcaggttgg aggatacaaa ccgagcacag 2759041 tcatcgattt cgagattcct aaacggtatg ggctgcgcca gacgatcgcc gatacagtag 2759101 gcatcggcgg gatattcaga tctctcagaa caatcccggt cttatttgat atcgcaaaag 2759161 atatggagga aatgtgccct gacgcatggt tcttaaacta tacaaatcca atggccactc 2759221 ttacaggcgc catgctccgc tataccaata tcaaaacaat cgggctctgc cacagtgttc 2759281 aagtgtgcac gaaggattta tttaaagctc tcggaatgga gcatgacgga attgaggaac 2759341 gcattgcggg cattaatcat atggcttggc ttttggaagt caaaaaagac ggcacagatt 2759401 tatatccaga aatcaaaagg agagcgaaag aaaaacaaaa aacaaagcat catgatatgg 2759461 tgcggtttga attaatggat aagttcggct attatgtcac ggaatcgtcc gaacataacg 2759521 cagagtatca cccgtacttt attaaacgga attaccctga actgatcagc gagctgcaaa 2759581 tcccgctcga cgaatatccg agaaggtgcg tcaagcagat tgaaaattgg gagaaaatgc 2759641 gggatgatat cgtcaataat aaaaacctta cgcacgaacg ctcaaaggaa tatggttcaa 2759701 gaattataga agcaatggaa acaaacgaac cattcacctt cggaggaaac gtcttgaata 2759761 cagggctgat caccaacctt ccttcaaaag cggttgtgga agtgacatgc gtcgccgaca 2759821 gaaaaaaaat tacaccgtgc ttcgccggag aactgcctga gcagcttgca gccttaaacc 2759881 ggacgaatat taatacacag ctgatgacaa tcgaagcggc tgtcacacga aaaaaagaag 2759941 cggtttacca agctgcaatg cttgatccgc atacaagcgc ggagctttcc atgaaggaca 2760001 tcatctccat gtgcgacgat ttatttgcag cacacggcga ttggcttccg gaatacaaat 2760061 aaaaactagg ggaccgctct cccctagttt tttggttttg tttcgccttc ccaggccatc 2760121 atgccgcctt caacattgac tgttttaaag ccttgctcat ccaggtactt gcagacgttc 2760181 atgctgcgca ttcctgagcg gcagataaat acgtactctt tgtctttatc aagggtttcc 2760241 attttttcag gaatatcccc catgcgaata tgaacggctt gcgggatcat gccttccgct 2760301 acctcttcat cttctctgac atcaattaaa tataattctt cgtccgcctc aattttttct 2760361 ttcaaagcgg ctgtgctgat ttcttttatt tccaaagaaa acactcctat tcacagtgat 2760421 catgttcagt atatcaaagt cagccgaacg attgctattc tgagactgat gaaaaaaaat 2760481 ccccttttgg caaaggggat tttttctagg cttagtttgc cacaatattg acaagcttcc 2760541 caggcaccgc gatgattttc cgaatcgttt tgccttcaag ctgctctttg accttttcat 2760601 ctgcttgagc aagctgttcc agctgttctt tcgttgcatc ggcaggaacc tgtaatttcg 2760661 cttttacttt tccgttcagc tgaacaacga tttcaacttc atcatccaca agttttgttt 2760721 catcatatac aggccaagct tcgtaggcaa ttgtgccgga atggccaagc ttctcccata 2760781 gctcttccgc taagtgtggc gcgacaggag aaagaagctt cacgaagcct tccatatatt 2760841 ctttcggcag ttctgttgct ttataagctt cattaataaa gaccatcagc tgggaaatac 2760901 ccgtgttgaa acgaaggcct tcataatggt ctgtgacttt catgaccgtt tcatgataga 2760961 cgcgctccaa tgtttcaccc gcgccttcaa cgatttttcc attaagctca ccgctgtctt 2761021 caataaatag gcgccataca cggtcaagga aacggcgcgc accgtctaat cctgattcag 2761081 accaggcgat tgaagcatca agaggtccca tgaacatttc gtacaatctc agcgtatcag 2761141 caccgtgaga ggccacgatt tcgtcaggat tgacaacgtt ccctttagat ttactcattt 2761201 tttcgttgtt ttcgccgaga atcattcctt ggttgtacag cttttggaac ggttctttcg 2761261 tcggcactac gccgatatca taaaggaact tatgccagaa gcgggcatac agaaggtgaa 2761321 gcacggcatg ttctgcaccg ccgatataca tatcgaccgg aagccatttt tccaattttt 2761381 ctggtgatgc cagctgatcc ggattgtgcg gatcaatata gcgcaagaaa taccagcagc 2761441 ttcccgccca ttgcggcatt gtattcgttt ctcttcttcc ttttttccct gtctcagggt 2761501 ctgtgacttc cacccactct ttaatgttcg caagcggtga ttcgcccgtt ccgctcggtt 2761561 tgatttcatc cgtttttggc aaaatcagcg gcagctcctc ttccgggaca gctgttgacg 2761621 ttccgtcttc ccaatgaatg accggaatcg gctcgcccca ataacgctgg cggctgaaga 2761681 gccagtcacg aagacggtac gtcactttct tctcaccgtt tttcgtttct tccagccaag 2761741 cgatcacttt ttcaatcgct tcctgtttgt gaaggccgtt caggaaatca gagttcacgt 2761801 gctcgccgtc gccagtatag gctgcttcct caacgttccc gccttttacg acttccttca 2761861 ccggaaggcc gaatgttttg gcgaattcaa aatcacgctc atcgtgtcct ggaactgcca 2761921 tgacagcacc tgttccgtat gatgcaagaa cataatccgc aatccaaatc ggcagttttt 2761981 ctccgtttac aggattgatc gcatacgctc ctgtaaatac gcctgtcttt gttttcgcaa 2762041 gatctgtgcg ttctaggtca ctctttgatt gaatttcttt gatataagct tcaacagctt 2762101 ctttttgctc tgccgttgtg atgttttcca ccaatgcgtg ttccggggca aggacagtgt 2762161 atgtagcgcc aaacagcgta tctggtcttg ttgtaaacac tgtaaaggaa tcatcatgtc 2762221 catctatagc aaaatgaacg tgagcgcctt ccgaacggcc gatccagttg cgctgcatat 2762281 ctttaatgct ttccggccaa tcaagctctt ccaagtcctc aaggagcctg tccgcataag 2762341 cggtgatttt cagcatccac tgcttcattg ggcgtctctc taccggatgg ccgccgcgtt 2762401 cgctcttgcc gtcaatgact tcttcgttgg caagaacagt accgagcgca gggcaccagt 2762461 ttacaggcac ttcgtcaacg taagcaaggc ctttttcgta tagctttaag aaaatccatt 2762521 gcgtccattt atagtattca gggtcagtcg tattgatttc gcgatcccag tcatatgaga 2762581 agccaagcgc ttgaatttgg cggcggaagt tatcaatatt ctgcttcgta aacacagcgg 2762641 ggtcgttccc tgtgtcaagc gcgtactgtt cagctggcag gccgaatgcg tcccagccca 2762701 ttggatgaag gacatcatag ccctgcatgc gcttcatgcg ggacagaata tccgtagctg 2762761 tgtatccttc aggatggccg acgtgcaacc cagctccaga cggataagga aacatgtcca 2762821 gcgcgtaaaa tttttgtttt tcattattat caagagtggc aaatgttttg ttttcaagcc 2762881 aatatgtctg ccatttcttt tctatctctt tgtgctgaaa actcaaagta aaaacctcct 2762941 tctgattgaa tacggcgtgt atggttcaag tattgacggg aaggagagga ttatattcag 2763001 aatattccca aactaaaaaa aactccctca tcccaaaaag ggacgagaga ctttcgtttt 2763061 cccgcggtac caccctcgtt agcgcggcat acgccgcact cacttgatac ttttaacgca 2763121 gttatgcgtc agcggctttt caccgctgca actctgaggt gagttcggaa acaaacttga 2763181 ttgactttca ccagccgtca actctctgca acaatatctg tttcttactg ctcctcttca 2763241 ttgttcttat cgcaaccgta atctaactgt attttataga attctgttca taagtgcaag 2763301 caggtttgta tacaatggga atgtaccctg aacgggcgga gattgaggac aattattcgg 2763361 gtggagtttt ggtttgacgt ttggactcgg ccggttcgcc gccgctgttc agttctctca 2763421 caaagtcaaa acttctgaga acagcttcac cgccgtagcc tgagataatg gataagatga 2763481 caagttgaat tcctgaatcg gggtcagcgg ataatacaag taaaatggaa gccgtcatgc 2763541 cgataaacca atcttccaaa aatccaaggt agataaaccg cttcgtcatt ctgggcttct 2763601 ccagcctgcc tctctttttc acatgaccga gaatccccat gattcctcca attacacaag 2763661 caatgagtac ctgatgcagc atcttcatca tcaccttcct aaagccctta tttcgtaaag 2763721 cgacttcagg ccatccagcc cccttaaacg attccgatga ttttcgatat ctacataccg 2763781 gcaaatctgt aaaaagcttg tttcttccat tatatgtgaa cacatgatcg gtaagcttga 2763841 tgcattggat tcatttttca cccagtgaca ttgacctagt cacctattta gcatgtagaa 2763901 aacctttccg ttcatatgtt caaattctgt tcttattttt agtgtatacg aggacaagcc 2763961 ctaatgacaa acaacaaact gcacttgctt gaatcagaac atgtgttgtg ctacggttac 2764021 tgtagaattc atttttaaaa aggggaatat caggctttcg catagcaagc tgacggccta 2764081 agggggattt atatggctag ttttcaatca tttgggatac caggacagct ggaagtcatc 2764141 aaaaaagcac ttgatcacgt gcgagtcggt gtggtaatta cagatcccgc acttgaagat 2764201 aatcctattg tctacgtaaa tcaaggcttt gttcaaatga ccggctacga gaccgaggaa 2764261 attttaggaa agaactgtcg cttcttacag gggaaacaca cagatcctgc agaagtggac 2764321 aacatcagaa ccgctttaca aaataaagaa ccggtcaccg ttcagatcca aaactacaaa 2764381 aaagacggaa cgatgttctg gaatgaatta aatattgatc caatggaaat agaggataaa 2764441 acgtattttg tcggaattca gaatgatatc accaagcaaa aagaatatga aaagcttctc 2764501 gaggattccc tcacggaaat tactgcactt tcaactccta ttgtcccgat tcgcaatggc 2764561 atttcggctc ttccgctagt cggaaacctg acagaggagc gatttaattc catcgtttgc 2764621 acattgacga atatcttatc aacatccaaa gatgattatt tgatcattga tttatccgga 2764681 ttggcccaag tgaacgaaca aacggccgac caaattttca agctgagcca tttgctgaaa 2764741 ttgaccggaa ctgagttaat cattactggc attaagcctg aattggctat gaaaatgaat 2764801 aaactggatg ccaatttttc gtcgctgaaa acatattcaa atgtaaagga tgccgttaaa 2764861 gtgcttccga ttatgtaaaa agatcccgct cacccagctg gatctttcag attgttgaca 2764921 aaatcctaaa atggttttca ttttaggatt ttgtcatctt ttcagcgtga ttgaaaaccc 2764981 ttgaagtcta ggaaggacga gcataggagc ggagcgaatg ttctaattcg tgagcaccga 2765041 agcgcaggcc tgacaacgaa tgcgagggtt tgtcgacacg ctgaaagatc ccgctcattc 2765101 ggcgggatct tttattatga agagattgat gcctgcttat ttgtttcttt agctgatttt 2765161 atccgtttgt catatagaag cgttgtggca atactgatca gcagcaatac caacagagat 2765221 aaaacaagag ccctaatgcc gtaatgatcg acaagcactc ctccgaacag gggaccaatc 2765281 attctgccgc ctgtcgccgc actgttgaca aagccttgat aaaagccttc tttcccttta 2765341 ggggcaagct gattggcaat agtcggcaca gcaggccaaa caagcatttc tccgatagtc 2765401 aggatcacca tcgcagcgag aaacatcgga aattgctttg cagtcagcag catgctgaaa 2765461 gacacaataa aaatgataaa gccgatgacc atttgcgctt ttagcgactc ggcccatttt 2765521 ttcaccacaa aactgacgag cggctggccg agcacaatga gaattccgtt aaccgtccac 2765581 agcacgctgt ataaggaaag agatattcca atgctttgtg tgtacgaagc aattgtggtt 2765641 gaccactgag aataagccag ccatccgagt acatagcctc cgcttaaaat gatcagtgcg 2765701 gcaaattttg ctttgctgtt cacagcatca taatcaagca cggatgtttg ggatgcatcg 2765761 cccgtttgaa tatttcgaaa tccgaaatat acaataaaga aaaagatcag atacaatacg 2765821 gcatttgcca aaaatacata tgaaaacgag aaagatgcca cgacaccgcc aagcgctgaa 2765881 ccaacggcca cgcccgcgtt ttgcgcgaca tatatcgcat taaatgcctt ccttccccct 2765941 tcaggccata ccgatcccgc cattgcgtag cttgccggaa aaacaacacc ggagccaaag 2766001 cccacaatcg tcagcagcac aatataggct ggccaatcat gaaaaaagac aagacccatc 2766061 aggcttgcta acgtaatggc tatcccaagc ataatcgatt taaaaccgcc gattttatca 2766121 aacaaaaaac ctccgcataa attgccagcc acactggcgc cggaattcag catcaggaca 2766181 agtccggcta ctgttaacga ctttcctaaa tgattatgga tataaatcgt attcagcggc 2766241 cataaaaaag aagcacccgt cacattgata aacattccaa tgactaaaat tttaagagca 2766301 cgcggcatac tcatccccct ttcttaccta aaaaagctca tgaaaaaaac gaaacctaaa 2766361 acggctccgt acgaatccag ttatcatagc acattcattc tatctgtctc tctcacattt 2766421 ttcaactgat gagcgtgaaa aaatctaaca aatattgttt gaaaaatgta aaataaatag 2766481 aaaaaggggt catattatgg aaatggtatt agcattctta ggttttctgg catgtctcat 2766541 tgcactgggc tatggattat atcaccttgt cagatatgta ctgaaaaagg aaaaacgttt 2766601 ctcaaagaga cttttttggc cgcttttcat tggaggcctt gtgctgctct ttaccggggc 2766661 agcattggca gaacctgaca ctgccgcagc aaatgccgag aaaaaatatt cagcgctaaa 2766721 cgccgaatat aaaaacctca caaaagagca cgaagaactt gagaaagaat ataaatctgt 2766781 cagctctgaa gcaaagaaat taaaagacaa caaagaagat caagacaagc ttgagaagct 2766841 taaaaacgaa aatagcgatc taaaaaagac tcagaaatca ttaaaagctg agattaaaga 2766901 gcttcaagaa aatcaaaagc agctcaaaga agatgcaaaa acggcaaagg ctgaaaatga 2766961 aacacttcga caagataaaa caaagcttga aaatcaatta aaagagacgg aaagccaaac 2767021 cgccagctct catgaagaca ctggaagttc ttcaaacaat acgagtaaaa gtgatgaaac 2767081 caaaacagct gacaaagcag aaggctgtaa tatcaaagga agcagaaacg gcatctacca 2767141 cacgccaggc agtacatact acgaccggac aaccgatccg gctgaaatgt tttgctcagt 2767201 tgaagaagct gaagccgccg gttatcgggc gccaaaacga taaacaaaaa gctccagaat 2767261 gtctggagct ttttctgttt cacaacgacg atttaatgac cttcttataa taaagaactg 2767321 acagaaaacc aaaaatggag tagagcgcag tatataacac catcaccata atcataggcg 2767381 cccatacctc tgatccgaat aagaaccagc cggattggac ggcaaagtaa ctgtggaaga 2767441 ggccgacaac gagcggaatg ccgaagttgt acatttgttt gatgcgtatc ccctttatca 2767501 ggtcgccctg cgtaaagccg agttttctta aaattgtata gctcggtttt tcatcttcac 2767561 tttcacccat ttgtttaaaa taaaggatac aacctgatgt aatcaggaac gttaacccta 2767621 agaagccgac gatgaacatc accataccaa acagtgattt ttgcgcagcg cttgtatcta 2767681 gtcttgataa atgctcgttt ttcttgttca cctgttgaaa aagctcattt gctttttcca 2767741 tttgatcgtc atgtttcaca ttgacgccga taaatgtaga ttgcgccagc tgaatgcggg 2767801 ggtctttatc cttgtccagc tgtttaaaca ggctgtcatc cacaatgaca gcgggcatgc 2767861 ccccgcttgt aaacgtgtag gacacaagaa actcttctct taatccttta tattttaatg 2767921 gctgcgtctc gtgcttgctt tttactttaa taacaccaga gtccttgaaa accattattt 2767981 tttgcagcaa gtcggtgtat cctgagaaaa cggcttctcc agccgccaca tcgactcctt 2768041 ttacatcttt gtcgctaaca acagcaagct gcatattgcc gggatcgccc tgcatctctt 2768101 tcggagttcc atccataata tttgcaatgt caacatttgc ttgcaggaca ggtgttgcct 2768161 tttttacaaa cgagatgttg ctttccctca atttgttttc aaataacttg gcatctttct 2768221 cattcatgaa tgaaaaatca gccgctacat tttgttcagc ggtcttttcc gacgagtaat 2768281 acgagatgta agcaagagat aacagcccga tggcgagcgc tgaaacggtt gtaataatcg 2768341 tcagcagcag cgcattcgat ttcattctga acatgatcga agacagtgac agaacctcag 2768401 aaatatttaa gtagccgccc ttgctttttc gaatgatatt cgagataaac gtaactgatc 2768461 ctttataaaa caaaaacgtc ccgataatga cgctccccag aatgaagctc atcgcaacaa 2768521 acagttcatt aatggtctta aattttccgc caaacagctc agaagacaca tagtatcctg 2768581 tcaaaatcaa cacgatgcct aaagcgccga tcagcatttg gaaaaatgat attttcttca 2768641 ctttgtcttc agtggaggac gttactttaa acaaagataa aatactctgt tttttgataa 2768701 acgtataatt catgatcatg atcaaaaggt aaatgccgca gaacacaatg accgtttgga 2768761 ccaaggcctg ctcagaaaaa tgcagtttcg catccgcttt gacatcgaca attttgaaca 2768821 gaatcatcaa gacaagcttc gatatcgaaa acccggccgc taccccgatc gctaatgaac 2768881 cgaaatacag catgacattt tctgcactta agatgcgaaa aattttatgc ttcgtcattc 2768941 caattaattg aaacagcccg atttctttac tccgtctctt aataaaaatc gtattggcat 2769001 ataaaatgaa gatcgccact acagccacaa gcaaaatcga agcggtttta atagccgcgg 2769061 ctcccttgat tgaagccttc acttcgttaa ttgctggatc atactgcagc gtgacaaagg 2769121 cgaaataaag cgccacgcta aagatgagcg caaacacata caaatagtaa ttccggagat 2769181 tctttttcaa atttcgcagg atgagctgat taatgttcat gctgcacccc gcctaacacg 2769241 ccttgcgttt tcataatatc ctggaaaaac gtttgcctgt cctggccccc tttattcagc 2769301 tgtgtataca tttgcccgtc cttaataaaa atgactctgc cgcagtagct ggcagcgacg 2769361 ggatcatggg taaccataat aatcgtcgcg ttgcgttttt gattgagctg gctcagctta 2769421 tttaatagat cggaggccga tttcgaatcg agcgcgccgg tcggttcatc agcgaaaata 2769481 atgctcgggt catgaataaa cgctcttcca gcggatgttc tctgcttctg gccgccggaa 2769541 atttcattcg ggtatttatc ccgcaattca tatattccca gttccttggc aacttcctca 2769601 aacttgcgat tggcttcctt ttttgatagt ttcgtgatcg ataaaggcag aaggatattc 2769661 tctttcactg tcaatgtgtc taacaaattg taatcctgaa agataaagcc taaatgctgt 2769721 tttctaaatt cagccagctg cttttccttc atagccgtca tgtcatttcc attaatatga 2769781 atggttccgt gactgacctg atcgattgag gacagaacgt tgagcaaagt ggtttttccc 2769841 gacccggaag cacccataat actgacgaat tcgccctttt caatgtgaat atcgatgccc 2769901 ttcagcactt cctgtttatt cagcttgttt ccataacttt ttcgaatttt attcgcttct 2769961 aaaatcacca tttacgcagt ctcctttata ttggataatc tcattataaa aaggaatgcc 2770021 gggcttttcc ttcgatacgg cgaacaaaaa agaaaagcat gtgacatttt cgtcacacgc 2770081 ttatgacatg ttcaaattga ttccgtattg gaaaggttaa tgtaaaaact gttcccgcac 2770141 caaactccga ctcaacatca atatggatca ataacggcgc cgctgctttt tttgccaagt 2770201 acagccccat gccagttgac gcttgatcat ggtgatccgt tgtggatgta aaccctttat 2770261 caaaaatacg cggtacatct tttggatcaa tgcccctgcc acaatctttc acttggagct 2770321 gcgtctgttc ccctttttga aagcttttga tctcgatttc agaggcttcg ctgtatttca 2770381 ccgcgtttgt cagcagctgc ctgatgataa acgccagcca ttttgcatcg ctcagcactt 2770441 ctttggcctc gagctgtatg tcaaaaccga tccctttttg gatacaccac gattgtaaat 2770501 ctttgatttc tttaaagatc aaaggctgaa gctgaatgaa ttctactgac aggtcgtttt 2770561 caataaatga aatgcgtttt tgatgaagct gctgatcaag aagcaggtga atacgcagcc 2770621 attcatatga cagctgggat ttcagtgctt tttcttccat tctatcaatg attaaatgca 2770681 tcgctgttaa tggagttttg acctcatgga tccatgccat cagctcatct ttttcatttt 2770741 ccaatgctaa gcgatgccgt gctgcggtct gcttcaagtg ttctgtttgc ccggcaatgc 2770801 ttctttcaac cattgcttca aacggcgttt ccggttcatt tatggctgtc acatcgagat 2770861 tgttctccca tgttttcaag cttttataaa acgctgtttc tttccgatag cggaaccaaa 2770921 ggaatatgat aaaaaacaag atgcacaaat acaccatata aagtacattc ccaaatgata 2770981 tggaaggatc gacaaaagca atgaacagca tcaaagcctg ctgaaacaaa aacgcggcaa 2771041 tccagctccg cctttcgata aggaatgctt taatcataga acttgtcctc ttccttcgcg 2771101 atgtagccct ggcccacctt tgtctcgata tatgcaccaa gctgcagggc gtccagtttt 2771161 tttcgcaggc gattgacatt gacggtcagc gtattatcac taacaaaacg ctcatcgttc 2771221 cacaagcttc tgatcagctc ttcccggctg acgatcttgt ttttttgctc tattaattgt 2771281 tttagaatga acatttcatt tttggtcagt tcaacagatc ctttgtcatt gctgacgagg 2771341 ttctgctccg cgtctacagc agcgccgcac cacgttttaa tcgtactcgg ctccgtatta 2771401 taatggtgca cacgccggaa catcgcttgg attttcgcga tcagcacatc aaaatgaaat 2771461 ggcttttgaa taaagtcatc tgccccgagc tgcatggaca tcaccatatc agcaggatga 2771521 tcccgggagg ataaaaagag aatcggaaca tttgaccggg agcggatcag acggcaccaa 2771581 tgaaagccgt caaatttagg cagctgcaca tcaataatga cacaatcagg attaaccgcc 2771641 gcaaattcct gcagcacctg actgaaatcc tgaatgccgt atacatcata ggaccatccc 2771701 gttaaacgat ccttgatttc atgaaacagc gattcatcat cttcaatcag caaaagttta 2771761 aacaatcgac tcaccgcact ttttcctttt ttatcaagtg tatagcaaaa cgccagcatg 2771821 cgctatagaa aaagccggct gtctcagccg gctcgttcgc attataattc tcttctcaac 2771881 gctgtcagca cgttggtttt ggtagctttt ctcgccgggt tcattccgga aatgactgcg 2771941 acccctccgc aaatcacaac ggcaatgatc acaaggctcg ccgggatgta ggagaatgtg 2772001 taattcaaat cgcccgcatc gccaccgctt gtggccgcaa gaatcatcgg aacggccagg 2772061 ttgacaaggt agctcacgcc gtaagaaatg ataatcccaa tcacacagcc taaaattccg 2772121 atatacgcgc tttccatcaa gaacattcgg cgaatgattg acgggctcgc cccaatcgct 2772181 ttcataatgc cgatctcttg cgttctctct gtcaccgcca tcgtcatcgt gttaaaaatg 2772241 ccgatcgctg aaatgataac tgcgatacat ccgacaaaga tcagtccgat tttgaagacc 2772301 atgaagaagg tattggctcc ctcaagttca gtagtcactg atgtgacata gtacccgtca 2772361 tctgttagat catttgtcag ctgttccaca ttctcaaact tatcagcaaa aacaccaatg 2772421 ttcgtttcaa catttccgcc tttgaaatct aagaattccg aaaaatcttt tttgaattga 2772481 tcactgataa aaatatttga gtcctccatc cagtcttgag atggtttttt tgtaataccg 2772541 acaattttaa agtcatatgt ttttgttttt gtaacatccc ctgttttaga atctgtcttc 2772601 gatacactta gttcaattgt tttatttaga atatctttcg tatagccctt tggttctttt 2772661 atatcttctg gatttccttt tgcttcctcg atttttttgt tatattcttc cgattctttt 2772721 ttcgttaata atctctttgc gaagtcgtat cctactacga tttcattttc cgactttgcg 2772781 actcttccct tttccaattc catattggcc tttaattcat cattcatatt agtaaaaatg 2772841 agatttgagc tttcatttgt acgattgcct aaagtagctt tgtttggttc atacacttgc 2772901 gttctttcta caactgacct tacgtgatca tacttctcta aatcagcttt tttaatcggc 2772961 ttgtctcctt ccttgcccat tacgctgact ttcgttacaa tctgctggct cattgtcata 2773021 tctgtaatcg tcttttgaat cccaaatcca acggacgaca acacaaccaa aaacgcacac 2773081 gccattgttg tcgccagaat cgtcataaag acgcgaagcc tgtttttctt catatttctt 2773141 ctgataaaat gaacctgatc cttaaacctc aacggtaatt cctcctttta gcacaccatc 2773201 atgaagctga aattttgaat gtccgataga agcgacttca tcatcgtgag taatgatcac 2773261 aaatgtaatg ccacgctcac gattcagctg ctggatcaat tccagcactt catgttccgt 2773321 ttctgaatca aggcttcccg tcggctcatc cgctaagata atcgaaggat ttaaaatcaa 2773381 tgctcgagca atactgacac gctgctgctg gccgcctgac agttcattcg gataatgagc 2773441 ggcgtggttt tccagaccga cgcgtttcag catgtcctgc accttttgct tccgctcaga 2773501 tggcttgatt ccttttaacg ccagcggcat ttccacattc tcatacgtcg ttaaacccgg 2773561 gatgagctga aagctctgaa aaataaaccc gaaatggtca agccgaaatt gcgcccattc 2773621 cttttcatta aaccccgtaa catcagtgcc attaatgaca atccgccctt ttgtcggcga 2773681 tatgtagccg gaaattaaat tcaaaagcgt tgatttccct gagccgcttc gtccgacaat 2773741 gcaggcgatt tcccctttcg ccacgctcaa tgaaacatcc ttcaatactg gaacttcatt 2773801 ctcacggccc ttttttccga tcgtgaaaga atggtcgata tgctgaacat caatcatatg 2773861 ttctctctcc cttacaaaag tttcattttt ttataaatcg caaaataact aatcaagaaa 2773921 ccgattaccg cacctgtacc catgccaatg agataaccgg caaagctctc gcttgcagta 2773981 aatccaaaat agccgaagcc catgattcct atgataataa cgatgatctg caccgggcgg 2774041 ttaagcggct tccataagaa gaaatatccg tttctttcat tagacatttt aacaaagcta 2774101 atatagccga tgatgtaaaa aatgatagtc atgatagccg gaatgactaa ataatatggt 2774161 gaattctcag cccatttcga gtctacataa attatcggaa tgaaatactg cacccattta 2774221 ggtactggac catggataaa atctattgat ccgccaaaaa ggatctcgag gttgatcaca 2774281 ggcaggctga tgagtaaaaa cggcgaaatg gccacggtaa atgagactag aagctgtgcg 2774341 aaactattgc ctgtcaaagc tcctccggcc ataaccaaag aataagccag catgctaaca 2774401 ataatcattc ccaagctgta attgtgaaaa taaacggcct gatctggctt caaaagcatg 2774461 atcagcaaaa cagacaaaac ataacctatg agctgcggca ccacaatcac cattccgccg 2774521 gtaaggaact tcgcatgaaa tatctgccct cgtgtatatg gaaggcttaa tgtaaaatca 2774581 aagaagctct tgctacgttc aatcccaagc tggctgaccg ccaaaacgac tccccaaatc 2774641 caaaacaatg agataaatga gctatttaaa taatcaacgc tgaatacgca ggggccgacc 2774701 caattttctt ttccagtgac acagccttga tagatgagat acatatttaa aattgataat 2774761 ggattaccta atataaaaac caaaatggtg ataactaagg cgactttatt ctgccgccac 2774821 tctttgtaaa gcagtccgga atccggcaac tcacttccct ccaaacctaa ggcatttctt 2774881 acacttttgt tttcttataa atagagaagt agctcacaaa gaatccagcc actgctccaa 2774941 tgatcatacc caaaatataa ccaataatgg aatgtccggt atagtatcca aataaaccaa 2775001 atccaaggat gccgaaagcc ataaccagaa tttgcaccgg gcgatctaat ctgttccata 2775061 agaaaaagtg tccgttccgt tcacttggaa gcttcttgaa gcttataaag ccaatcaagt 2775121 aaaatagcat gctcattacg gctggaatca ataaaagata tttactgtta atcagccatt 2775181 catttacaac gtaactaatc ggtactaggt tcgataaatt gcttgccaga gagaaataac 2775241 tctcagggga agggaatatt tcccatatat tcgcaccaaa aacaacttct aggtttccaa 2775301 ccggcaatgc aataattaaa tacggcaata tagctgctga aaacgccgtt aacagttggg 2775361 caaaagcatt tccagttaac gctccggcgg ccatcaccag tgaaaaagcc ataaaactta 2775421 tcacgattac tccaatgctg ctgtgctcaa aaaagtagac gtgttcaggg ttatagacaa 2775481 gaatcagcag ccatgcaagt aaaaagccaa tcaattgtga cagcacaatc acaaaaccgc 2775541 ctaaccaaaa ttttgtctga aaaatttggc ttctgttata cgggaggctt aatataaaat 2775601 ccatcgtgcc tttcgaacgc tccattccga ggaagcagac cgccaaaatg acacccggca 2775661 cccagttgat atctatcaga ttgcttatgg aataattcac aataaaatca caatattgcg 2775721 ggtcttggcg atcaagacac ccttgataag acaaatacgt attaacgata gaaagcggat 2775781 ttgccaatac taaaaacgcg atacttaaca aaatcaccac ttgattctgc ttccactctc 2775841 gatagaggag acctcggtct accatctccg cttccctcca aacttcgcaa tgaacacttc 2775901 ttccaggttg acaggaagct cattccacac ttttggcttc agctctctca aaaagctctt 2775961 tttctcctca tcgcttttcg gaatcagcac tgtgtaaaac acgccggcct gatcgagcat 2776021 cggaatgttt tgctctctga tggccaaatt gacatctgta tcgaaggcca tttgaatttt 2776081 aatgtattct tcttttaact catcaagatc catgacgttg gtcaggctgt tatcttcaag 2776141 aaaaccaatt cggttgcaca tccgctctat gtcttcaagc cggtgggacg taatcaggat 2776201 gctcgtatca cgctctgcca cttcatcgac catcagctgc agcacatcat gccttgtcac 2776261 cgcatcaata ccatccgtcg gctcatcaag gaggatcagc gccggtctcg ccgcaaacga 2776321 cagaacgagc gatagctgct tttttaagcc tgtcgacagc tcacggtatt ttttcgtttc 2776381 cggaatttcg tatctgttca tcagctcatt cgcgtacgtg acatcaaatt tcggatatat 2776441 tcttctcaaa atatcgacta actgcttgta tgtatactta tcgtaaaacg gattttgaac 2776501 aggcatgtag atgatatttt gtttgacttt cgggtgcttt ttgatttcta cgccgtcaaa 2776561 taaaatcgtt ccgctgtcag cgaaaatgat ttgctggatt aagcgaagca tcgtcgtttt 2776621 gcccgatcca ttgcgtccaa gcaatccaaa gatttctcct ttttcgattg ttaatgaaac 2776681 atcttttaat acttgattgc cgtcaatcgc ttttgacagc tgccgcagtt caatcatttt 2776741 ttttgcctcc cttcacatca gcgctgattt cctttatcca ttcgtgcagt ttttccagct 2776801 caacccctgc atagtgtgca tcgatgatga gctgtttgag ttgctcttta atcatcgtca 2776861 tcttcccttc aaccagtgtc gtttttgcat tctccgatat ataggtccct ctgccccgca 2776921 gcgtttcaat aatcccctct cgctcaagtt ctttatacgc tttgctgaca gtgttcggat 2776981 tcgcaataat gatcgttgcc aattctctga cagaaggaag cttatcacca ggcttcatga 2777041 tccctttcaa acaaagctct ttcatttgct gaataatttg ttcgtaaatg ggtgttgagc 2777101 ttcttggatc gatttgaatc atttacttcc ctactttcta tacgatctga accttttata 2777161 gataaaaatg atcaattata cttttttgcc attcaaaacc gatcatcaca agaacaagaa 2777221 aaaaagaaca agcgatcaca gatgccgcaa tcagcattgg cacgttacgt ttgtttcgtt 2777281 ttttatgttt cataactgcc tcccttaatg tcaatatata aatgatttta tattagtgtc 2777341 tatagtgtat tacttcaatt agtacactta atacaataaa tactttgact cacaaagtca 2777401 atcctttttt tacaaaaaaa cggacccttt taaaagggtc cgttttccta cacatcaaga 2777461 gggtgctgca ggatcatatt attttgcaaa gattgaagct gaagtctcat tctgtacagc 2777521 tgttctctct gctgatcatt tgacgacagc catagtttat tcaaggcatt taccgcatct 2777581 tctagctgca tttgtgcatc actatattct tgatcgttat aatgctcttg tttagaagcg 2777641 attttcagct gttcttcagc ataatcatag gcctgcatac attgctggag atgttcatct 2777701 actgattgtc ttgttgccac agtaacccct cctcttggta atggaaatca tccatcattc 2777761 atattgtagc ctcatctgac tttattcaat aaagtaattt atggtcgata ttcatttgtt 2777821 ctcttgtgaa atgcgtgcta caattttagg atgcaatcgt acgcaaggag gcacatgaat 2777881 tgtgatgcag aacaatcctt ttccttattc aaatacggaa aaacgctatc atacattgaa 2777941 ttatcatctc agagaacatt tcggccataa ggtgtttaaa gtagcgcttg acggcggttt 2778001 tgactgtcca aatcgggatg gcaccgtagc ccacggaggc tgtacgtttt gcagcgcagc 2778061 aggctccgga gattttgctg gaaaccggac cgatgattta attacgcaat tccatgacat 2778121 caaaaaccgc atgcacgaaa aatggaagga cggcaagtac atcgcttatt ttcaggcttt 2778181 cacaaacact cacgccccgg ttgaggtgct tcgtgagaaa ttcgaatccg tcctcgcctt 2778241 agatgatgtg gtcggcattt cgatcgccac acgcccggac tgtctgcctg atgatgtcgt 2778301 tgattacttg gcagagctga atgaacgtac gtatttgtgg gtggagcttg ggcttcaaac 2778361 agttcatgaa cggactgcac ttttgatcaa ccgcgcacat gattttaact gctatgtgga 2778421 aggcgtcaat aaattaagaa aacacggcat acgtgtctgc tcgcatatta tcaacgggct 2778481 gcctttggaa gaccgggaca tgatgatgga aacggcaaag gccgtcgcag atttggatgt 2778541 ccagggcatt aaaatccatc tgcttcacct actgaaaggc acgccgatgg tcaaacaata 2778601 tgaaaagggc aagctggaat ttctttctca agatgattat gtgcagctcg tctgcgatca 2778661 gcttgagatc attccgcctg aaatgatcgt ccaccgcatt acaggtgacg gaccgattga 2778721 gttgatgatc gggccaatgt ggagcgtcaa caaatgggaa gtgcttggcg ccattaataa 2778781 agagctagaa aatcgaggca gctatcaagg aaagttcttt caacggcttg aggaggaatc 2778841 agcgctatga ttttgaagaa aattcttcct tacagcaaag aactgctgaa aatggccgcg 2778901 ggagagggag atattgtcgt agatgcgaca atgggcaacg gacatgatac acagttttta 2778961 gcggagcttg tcggtgaaaa cggccatgta tacgcattcg acatccaaga atcagccgtg 2779021 gccaatacaa aggaacggct cggtgacatg tatcaagcgc gaacaacgtt atttcacaaa 2779081 agccatgata aaatcgctga atccctcccg cctgaaacac atggcaaagt ggcggccgcg 2779141 gtatttaacc tcggctattt gccgggcggg gacaaatcaa ttacgacaaa cggcagttct 2779201 acgatcaaag ccattgaaca gcttctcagc atcatgaaag acgaaggtct gattgttctc 2779261 gtcgtctatc atggccaccc ggaaggcaaa gctgaaaaaa acgacgtgct cgagttttgc 2779321 cgggacttgg accagcaaac agcccgtgta ttaacatacg ggtttatcaa tcagcaaaat 2779381 gacccgccat ttattgtcgc catcgaaaaa aaagctcaga tcagcaaatg atttgagctt 2779441 ttttctttga atttttcatc caggacattt tttgaaattt ccggtaggct ctgccgttga 2779501 tataaaagaa aagggaggtt tttccgctgg ctttgatcag cttctttgcg agccggccca 2779561 tttccttttg gcctgccact ttatcatctg acaaataaac gccaagcaag ccgcgattga 2779621 ttaaacgatg gaagttttca tgcggaatgc cttgtaaatg ctcgtcggct ttatggataa 2779681 agtgttcaag ccggtccatc atctcttcat gagactgata atacgagcag aaattcaagt 2779741 ctccttccag caagtcctcc tcttgatcaa tcaaataatc aagaagaata tgaagaccct 2779801 gtatgtaagg aaaataactg tctcggattt ttttagcggt gctttctgtg aaatcaggct 2779861 ggaacgaata cgcaaccaga cagaaaatgc ctaacgttga gcctgcacag gctgaaaatt 2779921 cataccattc catctcaggc agctctgatt catattgagt aaaccacttt tcaagccgcg 2779981 gaacacgctc atgctcaata acgtgcttat gcacctgcaa atcgcaataa tagccgcaca 2780041 gttcaagcag ataaggttta atcatgtcat agtgctcaat ggagccgaga acacgctggc 2780101 acgttttaac cagttcatgc aaatatccgc tgtcatcctg ttcttccctg aattgataat 2780161 agttttgcag ttccgcccca actgtcagtg cgtcctgcat tgaggcatgg agcatccgaa 2780221 aatcctgcgg gtccagcgag gtgctgcggt cacacagatt gtccaaataa tcactaatcg 2780281 tttgatacgc gatgataaac tcgacacatt tctgcttttg gctgcctgac aataaggcca 2780341 gtatgccgcc gccttcacag tgaaacgttt tgtcccgaat acttgcggtt gcctgtgctt 2780401 tcaattcact gttatgaatc gattctgatt tttgcttcca tatgtccagc tcttgatgaa 2780461 cgagcggaaa aatatctcga tatacctttg ccatcaatcc aaaaggatgt tccggtactg 2780521 tcaacacatg caccccctac tagttcaaat atattgatca gtaaacgctc ttgctgcttt 2780581 aaaaacatct tctctctcgg gttcattgaa gatctcatgg taaagccctt cccactctct 2780641 gtatgcttta ttatgagaag caacaccatt aaaccacttg atgaccatcg ttttgtcaac 2780701 aagcttgtca tcaccggctt gcatcacaag aagcggaact ttcaaaaatg cctctgtcgg 2780761 caccattgcc gattcaattg tctttaaaag ctctctgtac catctgacag aaactttcct 2780821 gacgtataac gaatcatttt ggtcagcttc gatgacgtcc tcattgcgcg tcgccatatc 2780881 aattgataat cccgaatcaa ccttaagtga cggagcgatg acattcaggc cttttgatgc 2780941 aagatcaagc gctttattca ctttaatttg cagtccgaga cacggtgatg ataaaataat 2781001 tcccgtaatc cggggatttc tttgctgttt aacccattca atcgcgacca gaccgcccat 2781061 gctgtgacct agaagaaaaa ccggaagatc aaaggttcgc gctttatcta tccaagcatc 2781121 tacttcatca atgtattctt gaaacgagcg aatatgccct ctcgctcttg tcgttgttcc 2781181 ctgtccaggc aaatcgccca tgacaacgtg ataacccgaa gaccgccaca tttcaatcag 2781241 ccatttatat cgtccgtgat attcacttgc cccgtgaatg attacaatca cggcaacagg 2781301 tctgtctgct ttccaggtcc acatgatctt cacctcatac gaaatttaaa tagagaaaga 2781361 aggatgaatc ttatgatcta cccttataag gaacacaagc cagatatcca cccaacagcc 2781421 tttatagctg ataatgcaac aattaccggt gatgtcgtga tcggagaaca gtccagcatt 2781481 tggttttctg ttgtcataag gggagatgtt gcgccgacca gaatcggaaa cagagtcaat 2781541 atccaagatt taagctgcct ccatcaaagc ccgaacaaga cgctactcat tgaagatgac 2781601 gccacgatag gccatcaggt tacacttcat agcgctgtta tccgcaagaa cgccttaatc 2781661 gggatgggct caatcatttt agacggagcc gaaattggcg aaggcgcttt tattggtgcc 2781721 ggcagtcttg tcccgcccgg aaaaatcatt ccgcctggcc atctcgcctt tggccgccct 2781781 gcaaaagtca tccgcccttt gacggaagaa gaccgaaaag atatgcaaag aatacggtca 2781841 gaatatgtag aaaagggcca atattataaa tttcttcaac aaacataaga cctgcttcgt 2781901 cttactttac catttttcaa attatatttg aaagcaataa ccatcgttaa cccggacgtc 2781961 atacagttcg ggtttcgatt tttccataaa acgttcacat atagcatgaa acgtatgact 2782021 tttatcttat cacaaaacta taaacagcct ctgcaaaaac acatacctat tctttcctgt 2782081 tctctatttt ctatgagcac acacaaaaag agcccactgg gagctctttt tgtcagctga 2782141 tatttcgttc gctggcagca gccgcatttt ttttatgaaa cccttttcca tagtacacag 2782201 ccagcaagat gagaaaccat atcggcccga taatcacggc tactcttgta tcagggctgt 2782261 aagccataag aatgacgacg aatgctagaa atgccaatga cacataagac gtaaacggaa 2782321 ataaaggcat tttgtacttt aattgtttct tttcttccgg cttcaaactt ttcctgtatt 2782381 ttatttgaga aagcaaaatg attgcccacg tccaaatcgc tccgaacgtc gcaatacttg 2782441 taacccaagt aaataccttc gcagggacaa catagtttaa cagcactccg actaataaag 2782501 cgcccgctga agccagaaca gctttacccg ggatgccgcc tttcgtcagc tgaccatatg 2782561 cttgtggcgc ctctttctgt tccgccaagt taaacagcat ccgccctgtg ctgaaaatac 2782621 cactgttgca tgaagacagc gcggctgtca acacgacaaa gttaatgata cctgcggccg 2782681 atggaatgcc cactttttga aatgtgagaa caaatggact tccttgagag ccaatttcct 2782741 gccacggata aatagacata atgacaaata aagcgcctac ataaaaaatc aaaatccgcc 2782801 aaaatactgt atcgattgct ttggctaacg atttttgcgg gttttttact tcgccagccg 2782861 tcaccccgat catttcaatc cctaaatagg cgaacatgac catttgaaga gacaataaaa 2782921 ccccttttaa tccatgaggg aaaaatcctc cgttgttcca caaattgctg attccggttg 2782981 caatgccccc attgccgact cctgcaataa tcatcaataa accgacagca atcatggata 2783041 agattgcaac aattttaatc aatgcgaacc aaaattccag ctcgccgtaa gctttgacag 2783101 ccaggaaatt aacacccgtc ataatgacca gtgccgataa cgcccaaatc cagtttggca 2783161 cgtccggaaa ccagaacccc atatagatgc cgacagcagt gatttcggcc atacaggtga 2783221 caacccataa aaaccagtag ttccaacctg ttaaatagcc tgcaagcggt cccaaataat 2783281 cacgcgcata cctgctgaag gagcctgcga ccggtttttg aatggccatt tccccaagcg 2783341 ctctcataat aaaaaacatg accaggccgc ttgcggcata cgctaccaaa ataccaggcc 2783401 ctgctaattg aatagctgat gcggagccga ggaacaaccc tactcctata gcagctccta 2783461 aagacattaa agaaatatgc ctttcttcga gtccgcggtg cagctcttgt ttttgttttt 2783521 gcatgcttct tctcccctag aaaaaaatat cattatatca tttttctgaa tattccgtac 2783581 ggattgggta aatcaatgat gatggagaaa taaaaggata acaacaaggc tttcgactac 2783641 tcgaaagcct tgttgtctgt tacacaaaga tgacttcttt aggctgatgg ctcagctctt 2783701 caggcatata ccgtttttca atattgatgc tgtgccagat cataaagatt agcacagtcc 2783761 aaattttacg gctgttatca gccttgtccg cacaatggtc ttcaagaagc tgaaggacat 2783821 aatccttatg gatataagca tccgtttggc tttcttgaat aatattccgc acccattcgt 2783881 tcatttcgtt tttcagccaa tgacggatcg gtacagggaa accaagcttt ttgcggttta 2783941 atacgtgctc aggcacaatt ccttcagcgg ctttgcgaag aagatacttc gtcgtgccgt 2784001 tcttcgtttt cagctcatca ggaatttttg aagcgacgtc gaatacgact ttatccaaga 2784061 acggcacacg cagttccaaa gaattcgcca tcgtcatttt atccgccttt aacaaaatgt 2784121 cgccgcgcat ccaagtgtgg atatcgacat actgcatttt gttgatatcg ctgtacgagc 2784181 tgctttctgt aaagtaagtc ttcgtcacat cgcgatatga aaggttcgga ttataatgct 2784241 tcaacagctg ctttttgaca gactcttcaa agattttcgc gttaccgata taacgatcct 2784301 gaagcggagt gcagccgcgc tcaagcaggc tcttccctct cataccttca ggcataacgg 2784361 cagcaacgtg cagaagcatc tttttcaagc cggacggaat ccgttcaaac ggtttaagcg 2784421 aaagcggttc acggtaaatg ttatatccgc cgaagagctc atccgctcct tcacctgata 2784481 aagcaaccgt aacatgtttt tttgcttctt ttgcaacaaa gtacaacgga atcgctgccg 2784541 gatcagcaag cgggtcatca aaatgccata cgatcttcgg aagctcattc atgtattcct 2784601 caggcgaaat gactttgctg atattttcaa tgcccagcgc cgctgccgtt tctttcgcta 2784661 catcaacctc actgaagccc tgctgttcaa agccgacaga gaatgttttt aagcttggat 2784721 gaaattcctt cgcaacagac acaataaagg aagaatcaat cccgccagac aggaacgaac 2784781 cgacaggaac gtcacttctc atatgaacgt ttacagagtc atagatcgcg tctcggactt 2784841 ctttcacaag cttgtcttct tcagtctgaa ccggcttgaa gttcgctttg aaatacgttt 2784901 tgaatgtgat atcgccgtcc gggcggattg tgaattgtga acccggctct acttttttca 2784961 catgggcatc aagcgtgctt ggttcaggaa caaattggaa agacatgtac tgctgcaatg 2785021 cctctttatc tatttcaata tcattctgag caaccattaa actttttctc tctgaggcaa 2785081 aataaacctg atcattgatc gttgtgtagt acaacggttt aatgccgaat ggatctcttg 2785141 ccccataaag cacatgatcg tttttattcc aaatcagaaa ggcaaacata ccgcgcagtt 2785201 tggacgccgc ttcttcttta tagtgacggt aagtcgcaag aagaacctct gtgtccgaat 2785261 ccgtgttgaa tgtgtacccc tttgcttcaa gttcttctct cagttcgata tagttataga 2785321 tttctccgtt aaagataatc caatatgttt catcttcata tgataaaggc tgtccaccat 2785381 tttctacatc aataatgctg agccgtctga atccgaagcc gacgtgctca tcatggaaat 2785441 atccatcact gtcaggaccg cggtgaacga tcatttggtt catttgtttg attagttctt 2785501 cttgatcagc ggtttgagct aacggatgct tgttaaaaac cccgacaaat ccacacatag 2785561 tattgcctcc ataattaaaa ttgtcatcat tgaaccccta tttatagacg ctgtgaatag 2785621 tatttggttt cacagttatg taaaaaaata aacatgaata caacgataaa aaagggaaag 2785681 ccgcttaacc agtaagcggc tataaaatta ttctcctaac gcttctttac gcagctgctc 2785741 cgctttgtct gtgcgctccc atggaaggtc aacatcgtga cgtccaaagt ggccgtacgc 2785801 agcagtttgt ttatagatcg gacggcgcaa atcaagcatt ttgataatgc cggcaggtcg 2785861 taaatcaaag ttattgcgaa caacttcaat cagtttttcc tcagaagctt ttcctgaacc 2785921 gaatgtgttg attgagattg acacaggctg tgcaacaccg atcgcgtaag caagctgtac 2785981 ttcgcaagaa tcagcaagct cagccgcaac gatgtttttc gcaacgtatc ttgccgcata 2786041 agctgcagaa cggtctacct tcgtcgcgtc cttacctgag aacgcgcctc cgccgtggcg 2786101 tgcatagccg ccgtacgtat caacgatgat tttgcgtcct gtaagtcccg catccccttg 2786161 agggcctccg attacgaaac gtcctgtagg gttgatgaaa tattttgttt cttcatcaat 2786221 cagctcttca ggaacaaccg gattgattac atgttcttta atgttgcgct gaatttgctc 2786281 aagtgtaatt tcagggtgat gctgagttga aataacaatc gcgtcaatgc ggactggttt 2786341 gttattttca tcgtactcaa ccgttacctg tgttttgccg tcagggcgaa ggtacggaag 2786401 aatatcttct ttacggactt cacttaggcg gcgggctaat ttatgggcaa gtgaaattgg 2786461 aagaggcata agctctttcg tttcgttgca cgcataaccg aacattaatc cttggtcacc 2786521 cgcaccaatc gcttcaattt cttcgtcgct cattgtgcct tcacgggctt caagcgcttg 2786581 gtctacgccc atcgcgatat cagcagactg ctcatcaatt gatgttaaaa ccgcacaagt 2786641 ttccgcatca aatccgtatt ttgcacgtgt gtatccgatt tctttaatgg tttggcgaac 2786701 cgttttcgga atgtcaacat acgtagaagt tgtgatctct ccgcttacaa gaaccaaacc 2786761 tgttgtcaca gatgtttcac aagcaacacg cgcgttaggg tctttcttta aaatttcatc 2786821 taaaatgctg tcagaaatct ggtcacagat tttatccgga tgcccctccg taacagattc 2786881 tgatgtaaat aaacgacgat ttttactcat gatttgcttc ctcctgcaca aggcctcccg 2786941 aaagaccttg tatatatgat acggaactcg ctccctctta tacaatgtac agttatatta 2787001 gagaatgtta attggcatat ttatgaaata aaaaaacctt ttccatcgag gaaagggttt 2787061 ggtctttgtg cctttcactc ttatcgctca aggaatcata caaccttgca acaggttagc 2787121 accttggttg tctcactcag ttgaacataa taaataacag agaaaccggt tgctgggctt 2787181 catagggcct gtccctccgc cagctcggga taagagtatc cgctcaatga aatatcttat 2787241 cgtaaaaggg tttgcaatgt caatatgatt cagaagaaat aggcacctat attgagggaa 2787301 aacaatggaa atgcacacac aaaaaacaat aaatagtata gactatttga aaatatatgt 2787361 tatactaatt cacaattagc aaaacacaaa aaacgataaa ggaaggtttc atatgaactc 2787421 agttgatttg accgctgatt tacaagcctt attaacatgt ccaaatgtgc gtcataattt 2787481 atcagcagca cagctaacag aaaaagtcct ctcccgaaac gaaggcattt taacatccac 2787541 aggtgctgtt cgcgcgacaa caggcgctta cacaggacgc tcacctaaag ataaattcat 2787601 cgtggaggaa gaaagcacga aaaataagat cgattggggc ccggtgaatc agccgatttc 2787661 agaagaagcg tttgagcggc tgtacacgaa agttgtcagc tatttaaagg agcgagatga 2787721 actgtttgtt ttcgaaggat ttgccggagc agacgagaaa tacaggctgc cgatcactgt 2787781 cgtaaatgag ttcgcatggc acaatttatt tgcgcggcag ctgtttatcc gtccggaagg 2787841 aaatgataag aaaacagttg agcagccgtt caccattctt tctgctccgc atttcaaagc 2787901 ggatccaaaa acagacggca ctcattccga aacgtttatt attgtctctt tcgaaaagcg 2787961 gacaatttta atcggcggaa ctgagtatgc cggtgaaatg aagaagtcca ttttctccat 2788021 tatgaatttc ctgctgcctg aaagagatat tttatctatg cactgctccg ccaatgtcgg 2788081 tgaaaaaggc gatgtcgccc ttttcttcgg actgtcagga acaggaaaga ccaccctgtc 2788141 ggcagatgct gaccgcaagc tgatcggtga cgatgaacat ggctggtctg atacaggcgt 2788201 ctttaatatt gaaggcggat gctacgctaa gtgtattcat ttaagcgagg aaaaggagcc 2788261 gcaaatcttt aacgcgatcc gcttcgggtc tgttctcgaa aatgtcgttg tggatgaaga 2788321 tacacgcgaa gccaattatg atgattcctt ctatactgaa aacacgcggg cagcttaccc 2788381 gattcatatg attaataaca tcgtgactcc aagcatggcc ggccatccgt cagccattgt 2788441 atttttgacg gctgatgcct tcggagtcct gccgccgatc agcaaactaa cgaaggagca 2788501 ggcgatgtac cattttttga gcggttacac gagtaagctt gccggaaccg aacgtggtgt 2788561 cacgtctcct gaaacgacgt tttctacatg cttcggctca ccgttcctgc cgcttcctgc 2788621 tcacgtctat gctgaaatgc tcggcaaaaa gatcgatgaa cacggcgcag acgttttctt 2788681 agtcaatacc ggatggaccg ggggcggcta cggcacaggc gaacgaatga agctttctta 2788741 cactagagca atggtcaaag cagcgattga aggcaaatta gaggatgctg aaatgataac 2788801 tgacgatatt ttcggcctgc acattccggc ccatgttcct ggcgttcctg atcatatcct 2788861 tcagcctgaa aacacgtgga ccaacaagga agaatacaaa gaaaaagcag tctaccttgc 2788921 aaatgaattc aaagagaact ttaaaaagtt cgcacatacc gatgccatcg cccaggcagg 2788981 cggccctctc gtataaaaaa caaaagccaa gagcaattat gctcttggct tgttttaatt 2789041 gacggaatgc aaagaagtca gcttgtatgt aatgatggtc cggccttctt cccattgaag 2789101 cttctgcact tcagctgtgc ctgacttttc gccaaacttt gttttgcgta catccattgg 2789161 aatctccatc ggatatactc ggtatccgtc cttctctaac gtgaatatat tttcatctat 2789221 gcgaacttct tttccttttg tcacaatcag tgtattaaat tcaacaggca ttcccaaagt 2789281 gaaatcccct ttcgttctct tttttcttta tcataacata tttcactgtc agcggttttt 2789341 catccattgt gtgagctgcc gcacgatacg ccggttttct tttggcggga aataatgtgt 2789401 gaatgtactg tagtaccatg tttccaccgg cttatgcagt tgttttagct tctcttctaa 2789461 taaataggaa tgctgaatcg aaacattttg gtctttttct ccatggatta acagcacggg 2789521 agcctgaatt ttgtttactt ggtcaaacgg tgtcctccat tgatattcct caggcacctt 2789581 tttcggtgtt ccgccgatga ctcttttcat cattcgccgc aaatcctgcc gctcctcgta 2789641 tgtaagaatc atatcactga cgcctcccca ggaaacaaat gaagctgcct gcccgcccat 2789701 ttcgatcgca gtgagcattc ccataattcc gccgcgggaa aaaccgaaga tatggattct 2789761 atccttcttg acatttgggt gctgctgaag caggcgaaaa gcagaaaatg catcctccct 2789821 gtcttctccg gcaaaatcct cattgccttc tcctccttga ttgcctctgt aaaaaggagc 2789881 aaacaccaca aacccttggg atgcaaactg gataatccgg cccggccgaa ccatgcccac 2789941 gcttttaatc ccgccgcgca aatataaaaa tccgtcatat tgtcccggtt ccgccggctc 2790001 agccagaagc cccttaaccc gtaatccatt tgacagatag cagatcgtat acaaacgcac 2790061 atgctggctt ggcgacggaa atcttctttt ctctacaatc aaaacagccg cctccttttt 2790121 tctatatgct ttccttactc caaaattaca tccggagaac ctggttaggc attcacacat 2790181 ttttataccc atcatacgat atgtaaagca aaaaaggata ttaacttgat gcgaaataag 2790241 gaggttgtct atgtgaacag atggttaagg ctgggcttcg cctgtgtcgg cagtatcttt 2790301 ctgatgttcg ccctggcggc ttgcaagcag gaagaaacgc tcaccaaagt caaagtagct 2790361 gaagtgaccc attcaatttt ttacgcacct ttatatgttg ctgagtctaa aggttttttt 2790421 aaggaagaag ggcttgatgt cgatgtgaat acgacctggg gcggagataa aacgatgaca 2790481 tcgcttcttt ccaacggctc cgacatcgcg cttgtcgggt cagaaacatc tatttatgtc 2790541 gaagcgcaag gggctaaaga tcccgtcatt aatttcgccc agctgactca gacagacgga 2790601 acgtttcttg tcgcgagaga agatgttgaa cacttcgact gggatcagct gaaaggaaaa 2790661 acgtttctcg gtcagcgaaa aggcggcatg ccgcaaatgg tcggcgagta tgtactgaac 2790721 aaacataaga ttgacccgca taaggatata gacctcatcc agaacataga cttcgccaat 2790781 attgccaatg cgtttgcttc tggaaccggt gagtatgtac agctctttga accgcaggct 2790841 tctctctttg agaaaaaagg catcggccat atcgtggctt cattcggaga agaatcagga 2790901 gaggttcctt atacgacttt tatggcgaaa caaagctatt tgaagaaaaa tgaagacaca 2790961 gccgtcaagt ttacaaaagc catttataag gcgcagcagt gggttgaaaa tcattctgcg 2791021 aaggacatca cagatgccat taaagatgaa tttgatgata ccgacccaga cgtcatcgaa 2791081 acatccattg aacgctataa aaaacagcat tcatattcac cagaccctct gcttaacgaa 2791141 aaagaatggg agcttctcca aaccattatg gataaatcgg gagaactgcc gaagcacatt 2791201 ccatacaatc agcttgtaaa taaagaaatt gctgaaaaag tcacctcgga gaaataggag 2791261 gcgccatcta tgtctttctt acatgtcgac catgtaaccc atacttattt ttctattaaa 2791321 gaaaaaacaa cggctgtgcg ggatattcat ttcgatgccg aaaaaggcga tttcatctca 2791381 tttctcggcc caagcggctg cggaaaaaca acattgcttt ccattattgc cggtttgatt 2791441 gagccatcag aaggcagagt tctgattgaa ggccgtgagc cgaatcaaaa agaacataat 2791501 attggctata tgcttcagca ggattactta tttccctgga aatctatcga ggaaaatgtg 2791561 cttctcggtt taaaaatcgc cgacacgctg acagaagaaa gcaaagccgc tgcactcggt 2791621 ctattgccgg agttcggcct catagatgtg gagaaaaaat atccgaaaga actgtcaggc 2791681 gggatgcgcc agcgggctgc gcttgcaaga acacttgcgc ctaaccctag tctgcttttg 2791741 ctggatgagc cattttccgc gcttgatttt cagacaaagc tgtctttgga aaacctggta 2791801 ttccgcacat taaaggaata tcaaaaaaca gcagtgcttg tcactcatga tataggggaa 2791861 gcgatagcga tgagcgatac gatcttttta ttttcaaatc agccgggcac catccatcag 2791921 atttttacca ttcctaagga attggccgcg atgttgcctt ttgacgcccg tcaggaacct 2791981 tccttccaga cactgtttca aacgatatgg aaggagctga attctcttga gaaacagcaa 2792041 agaaaccatt gatctgcttc acgagcagta tcaattcaaa cagaaaaagg aaaagtggaa 2792101 ggtccattcc tttcagcttg ccatatttat tctctttttc tcgggctggg aaatctccag 2792161 caggcagggc tggatcgatc cgctgatctt cagctctcca tcagctgtgt ggcgattatt 2792221 gctggagaaa cttggtgacg gttctttact gtcacacatc ggcgtcactt tatttgaaac 2792281 ggtgcttggc tttttgctcg ggacgtttat gggcacgtgc ctagccgctt tgttatggtg 2792341 gtctaaccga cttgccagaa ttttagatcc gtatcttgtg attttgaacg caatgccgaa 2792401 agtggccctg ggcccgatcc tgattgtcgc gctcggtccc agttttatca gcatcattgc 2792461 gatgggagcc atcatcagcg tcattatcac aaccatcgtt gtctacaccg ccttccaaga 2792521 ggtcgacgaa aactatacga aagtcatgaa aacattcggc gcaaaaaagt gggttatttt 2792581 taaagaagtc atactgcctg catcctcccc cgcgattatt tcaacactaa aagtgaacgt 2792641 cggtttatca tgggttggcg ttattgtagg ggaattcctc gtttcgaagg tcggattagg 2792701 atatatgatt atttacggat tccaagtctt caattttaca ctcgtcttct taagcctgct 2792761 gatcatcgcc atcttcgcca ctctgatgta tcagggcgtc gagctgctgg aaaagaaatg 2792821 gacgaagggg aggacataaa aaacccggca catgtgccgg gttttttatt caatccatcc 2792881 agattctttc agttttttca agctgatcgg aagaacggaa tccttcataa taaagctgaa 2792941 ttttttattg cgggaaaggt tctccggcag ctcgtgaaac aaaaccgggc ctttcgtttc 2793001 aaagtaatca gcctgctttt caagcttttc tatatctgca aaatatatat tttttacaat 2793061 cactttttct tttccgagaa ctttatactg tccgagatac ttgaggcttt tgactctcgc 2793121 gcccgtctct tcctttactt cccggagcgc agcctcttct gcgcactcca tcggctctac 2793181 tttcccgcct ggaaactcat agcctctgtc ctcatgttct gttaaaagcc atttgccgcc 2793241 aaaacggcaa atcacccaga catgcttcgg gctgtccgag aaaggctgat cgtcaaagga 2793301 aagctgaaca gtattctgat aataatcttt aaactcgtac atgtttatcc ctcaaatccg 2793361 ttcctagcta tcttccatac atcataccac agttacgttt cttcggaagc cttttatcaa 2793421 aaaataaggg aaacccagca cgccgtcagg ttctgcatgc agactagctc gtacagtttt 2793481 tttgcgatac ttttgccgga aagtgcgacc gacgctctgg gctttattat gacccgcgaa 2793541 cagggaaaag ttacggtttg cgcttaaatt tattttttaa cgtttctaaa agatcgacaa 2793601 gcatctgagg aaccggtatg ccaagagagc tggctgtcac aacaatttgc acagattcat 2793661 aaagaatata aaacataata gccaagtcac gaattgatcc ctgtgtattc agcagctgat 2793721 caaaaaagtg gcatacagag atcagagcca gcgtgactaa ttttttgaca agccgggcaa 2793781 ataccttttt aaatgacagt ttgtgaataa tggtttcctt caaagtcgta ctgataaatt 2793841 caattgccat aagagagagc aaaatcagaa atgaatactg aaaacctcca aagaaaaaac 2793901 ccgctgctga aacgctgact gctaaaaacg aaaagatgcc aaagtctcta tccatttatc 2793961 ccaacatcct ttcacagaaa cggccttacg atattctatg gtaaacaagc cgaacggatt 2794021 ggatttttca gaaaaatgga ctggttgtcg cctatttttc agatacaaaa agaaaagccg 2794081 gacgtctttt ttaagacatc cggccgttct atttttgaac ttaacctagg taagctttta 2794141 gcatccagtt atgtttttca atattttgat ggatcgcaag aagcatgtcc cctgttgttt 2794201 cgtcaccgac ttcatcagct aaatccatgc cgtttttcag ctcttccgcg atgactgtga 2794261 aatcatcata tacgctttga accatttgtt cagctgtttc atttccagca gcttctttga 2794321 cagaagccgt ttctaaggat tccttcattg ttgcaatcgg ttttccgttc agcgccaaaa 2794381 gacgttctgc taagtcatca atataagttg ctgtttcgtt gtacagctcc tcaaactttt 2794441 catgaagagt gaagaaatct ttccctttca cataccagtg ataattatgt agtttcacat 2794501 acatgaccgt ccagttggct acttgtttgt tcactgcttg aatcaattgt tctgacatgg 2794561 tatctcctcc ttgttatatg actatgtata cccttaatat cgtacgctaa aacctctttt 2794621 ttacccttat ctgtcacgat ttcttctatt atgctacaat tgttaaaaaa cgggaggtgg 2794681 aatgtcatga cgcttctcat tacgataagt attttgattg tgctggctgt tttgcttgta 2794741 accatttgga cgactgtaaa agcctataat gtaaagcata ccattgatcc accacaagaa 2794801 aatcactctg attcacacaa tcaatgatga tgtgaatgct cctcttctga ctgattgctg 2794861 gcagcatcgg cgtctccgac ttggactttt aaggtcggca tgctatgctg tttttttgct 2794921 gtgacatgag attggacagt gtatacacca tcttccttaa acgtcgtttc caatcggtat 2794981 acgccttttt cttgtttcac cttaaacatt tggcttgcgt ctttttcccc ttctttccat 2795041 acttcaaact ctacttcatc ggcatccgtc acagcttcat caccatatga tacagctgct 2795101 tcataagcag cgctttctcc gggatttact ttttcaggcc cggtcagctt gacatccaaa 2795161 acctcgggcg tctcagctgt atttgcttta ctttcaccag atccgcatcc attaagcaat 2795221 aaagcagaaa aaagcagaac aaccaacatc tttttcatgc catcaccctt tcatcgttta 2795281 cctaaatagt agcaaacgct tacagcaaat ggtacacaaa atatgagacg tcacaaaaaa 2795341 gacctttttg cttaagcgca aaaaggtcct ttctatttta gccaaatact tttagcaatt 2795401 cttctttatc ctgtgaaagc cagaaacgca ttaaacgttt agcgccttcc agatcatgaa 2795461 gcttcgcttg gccgcactgc ttttcattcg cagcaggtat ttctgtaatc tctaccgctt 2795521 ccttcattgt gtcttcaagc agatcaacga tttccgctga tgtcggctct ccgctcacaa 2795581 ctagataata gcctgtctgg cagcccattg gagaaatatc aatgatatca aaatgatcgt 2795641 atttctcagc gtgagaacga atcgtaaacg cgagcaaatg ctcgagtgtg tgaatggtgt 2795701 caggcttcat cgcctgttta tttggctggc aaaaacgaat gtcaaattta tttacaacgc 2795761 cgtctgttcc cactttatgc acgccgcaat gtcttacata tggagcaaca accgcattat 2795821 gatcaagctc aaaactttct actgaaggca taatggcact ctcccctttt ttaaaaatgt 2795881 aatttcatta taacatactt ttccgataag aattattgat taacttttca atctgtgttt 2795941 tttttcttat acttgcatca gaaaggttgc tgaagaaaca tgaaaaccct attcatcgct 2796001 ctgatcagag gatatcaaaa attcatctcg cccctgacac cgccaacgtg ccgcttttat 2796061 ccgacctgtt cccaatatgg aatcgaagcg attaaaacac atggcgcttt aaaaggcgga 2796121 tggctgacaa tcaaacggat tttgaaatgc cacccgttcc atccgggagg agtcgatccc 2796181 gttcctgaaa agaaacaaaa acattaattg ttataaccgt ttacgataag atccagtttt 2796241 ccggttttag gatcaatgac taagccatgg accggaacgt tttcagggaa cagcgggtga 2796301 tgtttaataa catctacgct gtctttcaca ctcgcttcca ctgaatcaaa gcttttaaac 2796361 cattgatcaa agtctacacc ggagtacttt attgtttcga tgcgttcttc cggaatccct 2796421 cttgctttga ttttttcaag catgcttttg ctgctgattt tgctcatgcc gcaatcgtga 2796481 tgcccgatca cacacacctc atctgcattc agctcgtaca ctgcgacgag tatacttctc 2796541 atgatgcttc cgaatgggtg tgtcacaagc gcaccggcac ttttaatgat tttcacatca 2796601 ccgtttcgca aattcatcgc atgcggcagc agttcaacca gacgagtatc catgcaagaa 2796661 agaatcgcca tttttttatc tggaaatttt gatgtttgat acttttcata ctctctttgt 2796721 tcagtaaatg tcttgttaaa ttcgagaata tcatttagaa gactcatgtt cgttgtccct 2796781 ttctattctt tttactcttc aatatatcac aacccttgtt tattcgtcat aataaaaaaa 2796841 gacaaaccct caggcctgcc ttatttcccc atgttatagc gttttttgaa ctgctcaact 2796901 cgtccgcctt tttcattgaa tttctggcgg cctgtataaa acggatgcgt gtcagagctt 2796961 acctctactt taatgacagg atatgtgttt ccgtcctccc actctgctgt ttcattagat 2797021 gttttcgtag aggtgcttag aaaacggtag ccgctgttga catcctgaaa tatcactttg 2797081 tggttctttg gatgaattcc ttctttcatg ggtatctcct ttcaataaat cgtaataatt 2797141 acgttttatt ttataacctt acaaacgttt tgtcaatctt cttatatcct tccctctgtt 2797201 tcacatcgta aacctcatgg catttaagaa taggaagaat aatctaaccg aggaagcaaa 2797261 taataaaccc aaaatacata cagaacgtct ttttggaaag gtggtttacg attgtggatg 2797321 atttagtttt ggccagaagc ctttttggca cgacgatggg ctttcatatc attttcgcaa 2797381 cacttggagt cggtctgccg ctcatgattt tagtggcgga attgatctat caaaaaacga 2797441 aagatgacca ttatgcgatc atggcgaaaa gatggacgaa agcacaagcc gttttgctgg 2797501 gggtcgccat accgaccgga acgatcgcgg gcactcagct cgcgctttta tggccgggat 2797561 ttatggaagt catcggccgg gtgatgtccc tgccatttca aattgaaatc tatgcttttt 2797621 ttgttgaagc cctattcatg tcgatttatg tatacgctgc agaccgtttg tcacctgcaa 2797681 tgaggattgt tgctgttttc tttgtgttag tcggggcagc agcatccgct gttctgatca 2797741 cgaatgttca cgcttttgaa ggtacgcccg ccggttttaa aattttaaac ggaaaaatta 2797801 cagatgttga cccgtgggct gcgtttttta atcctagctt ttttatcact gccggccatg 2797861 tcgtgctgtc cgcgtttatg actggtgcgt ttatcgtggc ttctgttgcg gcgtataaaa 2797921 tgatccgaac gaggaaaaag gaaagggtct atcgctttca ccggaaagcc cttttgctcg 2797981 cactgacgat cggcggtatt ttttcattgc tgaccgcttt gaacggacac gaatctgcac 2798041 agatgctgta cgaataccag cccgaaaaat tagccggtgc ggaaggccta tttgaaacaa 2798101 gatcccacgc cccgctcgct atcggcggtt ttaccgaccc gaatgaagaa aaagtaaaat 2798161 gggcaatcga gattccatgg gctttaagct ttttggcagc gaaccgtttt gacactgttg 2798221 taaaaggatt aaatgcattt ccgagagatg aatggccgcc gcttttcatt cacacgctgt 2798281 ttaatgcgat ggttggtgta ggcatgctgc taattcttta ttccattatc ggtgtggtct 2798341 ggagaaaggt gctcaagaaa gaccgtttcc caacgtggct tttgatcatt ttcatgacag 2798401 caggcccttt tagtctcatc ggcattgaat tcggctggat tttcgcatgt acggggaggc 2798461 agccttgggt catctatcat ctgctgaaaa cgtcagatgt cgtaacaacg actggctcga 2798521 tcggggtgct gttcttattt ttcacatttg tttatgccgt gttaggcgca gctgtcgtct 2798581 acgtgctgct gtattatttc cgcaagcacc cggttgacga agatttaaat acagcggagt 2798641 cgtaatggct ccgcaaacag gaaaccaaat ggaaggaaga tcgtacaaat ggagatttca 2798701 actgacgctc tgatcgccat ctcaattatc tggggctttg tgtttattta cgccgtcatg 2798761 gcgacaatgg attttggagc gggattttgg tctatgatct atttaaacaa ggagcatatg 2798821 aaggccaccg atattgcgaa tcgctttttg tccccgactt gggaggtcac aaacgtcttt 2798881 attgtggcca tcgtcgtggc gcttttcagt tttttccccg gcgcgacatt tgtgctcggc 2798941 accgttttat taattcccgg aagcatgatt ttgctgcttt tagcaattcg aagcggattt 2799001 ctcgtgtttt caaatacagc aaaggagcgg aaaacgctaa gatatatttc cggcatctcc 2799061 ggctttatca ttcctgctat tttaattttg gtgcttcctg tgacacacgg agggtttata 2799121 gaaaaaacgg atggaatcta taacttaaat atgtctaaaa tcttttcaag ccccaacgcc 2799181 tattcattta tcgggtttgc gattttaagc accttatttt tgtcctcgct gttgcttgca 2799241 gatttttcaa atgtggcaga ggaacaggat gcgtaccgag cctacagaaa aagcgccctg 2799301 attaccggcc cgatttcact gttgtttgct gtatgcatta tggtaactat gcggaatgaa 2799361 gcaaactggc tgtacagcgg aatgatgaat gatttttctt ggattattgc atcgttcatt 2799421 acatttgtca ttgctggaat cgctcttttt ctgcctaaca aaagctttgg tcaaaacatc 2799481 ggaaaaccgc gtctcgcact tgttgcgatt gggatacagt attttctcgc aagctacgcg 2799541 tacgggcggg cgcatcttcc gtatatgatt tatcccgatg tgacagtcat gtcaggcttc 2799601 acagagccag caacgttcag agcgctgttt gcaacgtata tcgttgcatt tatcattcta 2799661 tttccgggct tctttttctt ctggaaaatg tttatgcgag ataaacgcta tatccgccag 2799721 gaggaataga gggcaagcca gccggctata ctaatccaga acctttataa ggaggggatg 2799781 gcatggagca gaaaattcta tgtgaggtca acaactgttc ttattggggc aaaggtaaca 2799841 aatgcaccgc tgatgccatt tatgttgtca gccatactgg tgaaacggct gaaaacagcc 2799901 gggaaacaga ctgcaaaacg tttaagccgc atgatttata attaaaagaa agagctgcat 2799961 cagccagctc tttctttttg catgttgagt gttctcagct ttttagttat gaccccgttt 2800021 gcaggtgaaa acaaaaaggc gcttgcataa catacacctg tcatggccgc catcgctcct 2800081 gaaatcgaaa cattaagcca cgttgcgaag aaatagccca tgaccgccga cagcccgcca 2800141 atcaacgcgc tgagaatcag catataaaga agccggtctg tcagcaaatg tgccgcagcc 2800201 ggcggaacaa tcagcatggc cacaaccaat acggcaccca ccgaatcaaa ggaagcaaca 2800261 gtcgtcaagg acagcatgcc catttgcacg taatgaatga gcaaaaccgg tattcccaag 2800321 gctaaagcca tttgaggatc aaacgaagcg attttaaact ccttatagca cacactgatc 2800381 aacactacgt ttaaaaccag aacagatgcc agcatccaaa acgctttcgg cccaatatca 2800441 accccgaata ccgtcaccgt attccacggc acaaaagcga tttctcccat taacgagtgc 2800501 tcaatatcga gatggacatt cgctccatac acagaaagca aaataacccc gattgcaaat 2800561 aaggatgtaa acacaactcc tatggcagca tctgattgaa cccccttgct atgaagaagc 2800621 tgaaccaaga aagccgttaa cagaccggtt gcggctgcgc caataaacat ataaatccca 2800681 tcgagacttc ccgtcactag aaaagcgccg acaatgccaa gcaacactgt gtgactgatt 2800741 gcgtcggcca gcatcgccat gcttctcagc acaagaaatg tgccgatcaa tccgcagctt 2800801 acaccgacta atacaccggt agctataatc catgcttcaa aactcatttg cgatctgtcc 2800861 cttctcggca tcatgagacg cttttcgacg ctcaggcatc cgtccataca gctttaagag 2800921 tgaataaagc cgctctctcg tttctctcgg taaacggtcc gggtcaaagt agtcctgatc 2800981 ggattctata ttggcaagtt ccatttcatg catgagatac acttcataca tccgctgctt 2801041 caaagctgtg tgatagcctt tttctatccc tttgcttgtg atttgccaaa tcccattttc 2801101 gatacgctca atgcacctct cttgttccaa gtcatttaat gccttaaggc ataatgaagg 2801161 ggataggcgt cttttctttc ttacactttc aacagttaca caaagattat tcttttcata 2801221 ctgttcataa atcgccaaaa gcacttgctc cctgcttgtt ctgcgccgca gcctcatcag 2801281 ccttatggct ttagcagcca atccccgctt aggcgcgcaa atcattgaaa aaagaaagag 2801341 cagcgttgca gataagatca ttaatggccc tgtcgccatt cccttcatcg tggtgctaag 2801401 cagggttccg gccactccgc tgaccccgcc tgtaatcccg gcaatgatga tcatcccggt 2801461 taatcgttcg gtccaatatc tcgcggttat ggcaggtgta atcagcatag ccgccattaa 2801521 tatcacacca acagtctgaa gcccaatgac gacagcacag acaatcagac aagccaaaag 2801581 cccgtttaaa aaacgcaccg ggattcctaa tccctttgca aacgcgagat caaaagtaat 2801641 caatgtaaat tccttaaaga aaacaataca taggagcagt agaacagcgg atatccctgc 2801701 aataaggatg atatcctgcc tgaccaatga agcagcctgg ccgaataaaa aagaatcaag 2801761 cccgctttgg cttcccgccc cctgttgctg aatatatgtc agcagaatga tcccgacgcc 2801821 aaaaaacaca gaaagaacaa tcccgatcgc cgagtcctcc tttgtttttg aaagccgagg 2801881 aatcagctga atacaaaacg ttccgagcag tccggcgagc gctgccccca gcaaaaagaa 2801941 aggcagtgat ttttgcccgg tgaacagaaa agcgagacac actcccggca gagctgaatg 2802001 ggccatcgca tcgccgatta aactttgctt tctcagcagc acaaagctgc ccaaaacacc 2802061 gcttgccgtc ccgagcaaaa gcgtaccggc cagcacccac tgtgtattcg gatgctgaag 2802121 ctgcagccac aaactttcaa acattgcgct cactccttat gtccttctgc cagcacttta 2802181 tcttttaaaa acgtaagcct tcctccatat gttttttgca ggttttcgat cgtaaaaacg 2802241 ttttccgtcg gtccgaaagc gattttcctt aaatgaagca gtaagatcca atcgaaataa 2802301 tcctcggcgg tctgcagatc atgatggacg acaagcacgg tttttccttt ttctttgagt 2802361 tctgccaaca gcgtcataat cgcgcgctcc gtcgctgcat caacacctgc aaacggttca 2802421 tccataaaat aaatgtcagc gttctggcag agtgcccggg caagaaacac ccgctgctgc 2802481 tgtccgcctg acagctggct gatttgcctt ttcgcataat catgcatccc gacttttgtt 2802541 aatgcggcct tcgccatctc cacatccgct ttctttggcc tctttaataa accgattctc 2802601 ccgtatcttc ccattaggac gacatcgagc gggcttgtgg ggaaatccca gtcaaccgag 2802661 ccgcgctgcg gaacatatcc gattctggtc cgctgatcct tatagtcttt gccgtaaata 2802721 gagatgtctc cggaagctct gggcacaaga ccgagaatcg ttttgatcaa ggttgatttt 2802781 cccgcgccgt ttgggccgat aatgccaata agttttcctt caggcacctg cagcgaaatg 2802841 tcctgcagta caggcttttt atgataagca accgtcacat tatcaagctc aacagggaac 2802901 atatcctcca cctcttttct ttatttaagc gctttagtaa tcgtgttgat attgtggcgg 2802961 aacattcctt cgtatgtgcc ttcttttgtg cccttttcac ccatggcatc cgaataaagc 2803021 tgaccgccga ttgtgactgt atggcctttt tctttagcgc cttccaccac tgcattgatt 2803081 gatttttcag atacactgct ttctacgaac acagctttta tttgtttttc tgtcagaaga 2803141 tcaaccagct cctgaacatc ccttaatcca tagtccgaat ctgtgctgag tccctgcagg 2803201 ccttttacct taaatccata ctcattccca aagtacgcaa acgcatcatg agcagtcaca 2803261 agcacacggc ttttctccgg aatatgtgcg atctccttac gcgaccactt atctaaatat 2803321 tgcaaatctt ctttgtactc tttggcattt ttccgaaagg catctgcgtg ctgaggcatt 2803381 gctttgctga attgcgcttc aatttcatcc accgcataga tccataacgg aatgctgaac 2803441 cagacgtggg gatcaaacgt cttgccttcc cccgcgggaa taagcttatt tttcggaatg 2803501 gcctcagcta ctgccgccga ttgtttttgt tcgccgattt tttggaggac atcctccatt 2803561 ttcccttcca aatgcaaccc gctgtacaga acaacatcgg cagacattaa ttttttcgtg 2803621 tcaccttggg aagctttgta aaggtgcgga tcaacccccg gtcccattaa agaggtgact 2803681 tttacgtgct tacctccgat gttttctgct gcatcggcaa tttgagatgt tgtcgctgtc 2803741 acttgtaatt gctgatcagc gctttttccg gctgaatccg ttccgcatcc cgttaaagca 2803801 aaggtcgcaa aaagtactgc tgccatcagc ccttgtctca tatttctcct cctctttgcc 2803861 atcaatgtcc gattgtttta tcttatgttg tcagttctta gacatgtgac attaaattag 2803921 ccaaaagcat gttttattta cacaggacaa aaagtttccc tcatgcaaaa ttatcgcgtt 2803981 tggccatttt tgtcaagctg atttacataa aaaaaccggc tgggtcagca gccggtccaa 2804041 acgagaaggg atgtattcaa cgaacacttt tactgtaaca gcacagtgtc atttattcaa 2804101 aatagcaaaa tgcttttttc ttaaccatgc tgtgtgaaaa catccatttt ggtcacatat 2804161 tttcgcataa tatcttggtt tacctcaacc cctaaaccag gctgttttga cacagaaata 2804221 aatccattat caatacgaat atcaggagtt acaatatctt catcccaata gcgtgaggat 2804281 gaagatatat cgccaggtat tgtgaattga ggcagtgaag caagcgccac gttctgcgct 2804341 cttgatatgc ctgtttccag cattcctccg caccaaacct gcatatgatg ctctttgcat 2804401 aaatcatgaa tttttaaggc ttctgttaag ccgccgacac gagaaggttt tatattaata 2804461 attttgcagc ttcctagctc aatcgcccgt ctcgcatcat caactgaaca aatgctctca 2804521 tcaaggcaaa tggccgtttt caaatgtttc tgcaagtggc ggtggtcaac gatatcgtca 2804581 gcttggagcg gctgctcaat catcattaaa tgatagtcat caagctcctt taaacggctg 2804641 atatccttca gttcgtaaga ggaattggca tcggccataa gcgggatggt tgggaatcgg 2804701 ctgcggatgg ccttgaccaa ttccacatcc tgcccaggct gaattttaat ttttattctt 2804761 tgataacctt ctttttgata gctctcaatt tccttcagca tatcgtcaag aggcgccagg 2804821 ccgactacca ccccggcagg gactttatct cttgttccgc ccaatgcctc agcaagggat 2804881 acgcccttct ttttggcata aatatcccat acagccgatt caagtcccgc ttttgccatc 2804941 cggtttcctt tataccgcgc caggctgtcc ggcacttctg aagggtgatt gaattcacgg 2805001 ccgacgacat ttgggataaa aaaatctttt agcatatgca aacatgttcc aatggtttcc 2805061 tcggtgtacc aaggcgaaga gaaagcggaa acttctcccc agcctgtgac acctgatgta 2805121 tcaatggctt ccacgatcag aaatttacgc tcttgaagcg tttcgatact gtttttaaac 2805181 ggtttcttta agttcatgct caaatggtaa agcgtgattt tttctatttc gatcatagca 2805241 gttctccttt acgcgcatcc ttcagctgat ttcgcaagag cttattagac gcattgcgcg 2805301 gcaggcggtc aagcacaaag aattttgccg gaattttata cttcgccaag cgttctttgc 2805361 agtagtcagt caattctcct gcgctcacag gcttgtgaag gacaagatag gcgtgaggca 2805421 ctttccccca ttttttgtcc tcagcccctg aaaccccggc ttcggccaca gcggggtgtg 2805481 aaagcagcac tgactccact tcggccggat aaatgttttc tccgccggat atgatcagat 2805541 ctgaacgtct gtctaataca tataaaaagc cttcattgtc caaataacca agatcacctg 2805601 ttttcagcca gccattttga aaggaggctt cgtttgcgct ctcccggtta aaatagcttt 2805661 tcatgacatt cgggcctttg accatgattt caccgtgttc atacggttca catacctgtc 2805721 cgtcccgctc tattttgatt tcacacgaaa acagcggttt ccccgcagat ccgagctttt 2805781 ccatgctgaa ttccggcgac agggtaacaa tttgcgagca tgtttctgtc attccatatg 2805841 actgaaagac agggaatcct ttctcacggc attcctcaag caatggcagc ggtgcaggac 2805901 cgccgccgag aagaatgcat ctgatggatt cagggcagcg gtttgtttct tccaaaagac 2805961 tggccagcat agtctgcacc gcagatatca ttgtcacttc atgcctgttg atagaatgca 2806021 gcacatcgct tacggaaaaa cgctggtgaa gcacgacagt cattccatag atcacagatt 2806081 taaataatgc ggacaatccg ctgatatgaa agagcggcaa tgcgataagc cagcggtctt 2806141 gttctgttat acccaaatta agagcggacg acaccgcact gaaataatgg tttccgaacg 2806201 tttgctgaac tcccttgggc tttcctgtcg tacccgacgt atacatcagc gttgccgttg 2806261 catccatttg catataagcc tcgatctcaa tttcctctgc tgcttctttc atcagttcat 2806321 ccacatcaat cgtttgaacg atgtgttcat attctttctt ctcaaagctt gaatctgtca 2806381 ataaaaagcc ggatcccgaa tcctccagct gaaacagcct ttcatgtgtt gacagcttcg 2806441 tattcaaaag caccgcctta acaccaagca aaaaacaagc gtgaacagcg tataccattt 2806501 ctgcacggtt ttggagcaaa atagctgcag tatccccttt ccgaaccgaa tgagcggcaa 2806561 gctgttccgc cattcgttta gacgcggcaa acaattctgc aaatgtcacg gtttggtctt 2806621 catagatgag agcgattctc tcaggtgtca gctgtgcccg ctgcatgagc cagttgggct 2806681 gttctgtcag catgtcatca tctccgaggt aaaatgtctg tattgaaaag aaaacagctt 2806741 ggaccgcaaa gtctcaagct gttggtttac tagatattgc tgatcacgga aaacgaggga 2806801 actgtccgaa atcaggtttg cgtttttcct taaaggaatc acggccttct tttgcttcat 2806861 ctgttgtgta gtaaagaagg gtagcatccc ctgcaaactg ctgaattcca gcaagtccgt 2806921 ctgtgtccgc gttaaacgca gctttaagaa agcgcagtgc ggtcgggctt ttttcaagca 2806981 tttcttcaca ccatttaatc gtttcttctt caagctgttc caaaggaacg actgtgttga 2807041 caagacccat gtccagtgct tcctgtgcgt tgtactgacg gcataggtac cagatttcac 2807101 gtgctttttt atgtcctaca attcgagcca ggtagccaga accgtaacct gcatcgaagc 2807161 ttcccacttt agggcctgtt tgtccaaaaa ttgcgttgtc cgcagcaatt gtcaagtcac 2807221 atacgatgtg aagcacatgg cctccgccga tcgcatatcc ggacaccatc gcaacaaccg 2807281 gtttcgggat gacgcggatt aaacgctgaa gatccaatac gttaagacga gggatctggt 2807341 cgtctcctac atatccaccg tggccgcgca ctttttggtc tccgccagaa caaaatgctt 2807401 tgtcccctgc accggcaagc acgataaccc caacgttttg gtcgtctctt gcgtcagcaa 2807461 acgcatcaat catttcagca accgttttag gggtaaacgc attatgtacc tcaggtcggt 2807521 tgattgttat ttttgcaatg ccattatacg tttcatacaa tatctcatcg tatgtccgtt 2807581 ttgttttcca ttcagccata tgatgacctc cttttattct ctatgtgaat gagtcagatg 2807641 cttgtcaaaa actcactcac tattttacca aacaatcgcg gctgctccac atggaccgta 2807701 tgtcctgctt ttggaacaat ctctattcta ctagaaggaa gcatcttatg cacctcttga 2807761 ttgatggcgc aaaatttttc gtcccactcc ccgcagatca gaagcacagg aacatctatt 2807821 tcctctacac ggctccacaa ggaaggctgt gaaccggtgc ccatgccggt taaactgttc 2807881 gcaagcccaa tcttattgtt ccgcagacgg cccgatcgta tcctgtaccg aatatcttca 2807941 gccagcctct gctgagatga aaacaaaggg atattctccc aatacgcaac aaacgcttcg 2808001 agcccgtctc gtaaaataaa atcagcaagc ttccggtccc gcatgattcg ttcccgccgt 2808061 tccccaagtg ttttgagccc cggcgtcgtg ctttcaagca caagtgccga tacccgctcg 2808121 ggatatgtca tcgcaaaaga gtaagcaagc cttcctccca tagaataccc aatcaatttc 2808181 actttgtgaa gttttaattg atcaaaaatc tcggcaaggt cagaaacttg ccgggttgtg 2808241 ctgtatcttt tcccattcag cggggcatcg gtttccccat gccctaaaca atcaattttg 2808301 atcaaacggg aatcaggcag catttcatca agaaaagtcc atgattgttt gctgccggta 2808361 aacccatgca gacagacgac ggcttcggaa gcattcggtc cctcgtctgc cactgcatat 2808421 cggacaccat ctgataccgt tatgtttaca gttcccattg ttttttcact tcccgcacag 2808481 cctcattcag catatcgcga tgaagctgga ctcttgattg gcgatccgtt ttgatttcaa 2808541 tcaaatggag tccgggcttg tctgcctgcg gcgcgtaagc tgttttgaat tcatcccaag 2808601 aagccgggca tgaatacgtt ccgccgtaaa gtgcagccgc atgcttgaaa tcgagccctg 2808661 tcggtgtgcc gaacaaatct tcaaagtgtg tcttctcaga agcctgcggc aaaaaggaga 2808721 aaatccctcc tccgtcatta ttgacaagaa tcacagtaag aggaataccc agctttttgg 2808781 ccgccagcag gccgtttaaa tcatgataaa aagataaatc tccaatcaca agggtaacag 2808841 gcgcttttgt tccttcacat acccccatgg cagaggagac gacaccgtct atcccgtttg 2808901 ctccccggtt tgaataaatc cggaaagggc ggtcctgctt ttcaaaaaac gtatcaacat 2808961 ccctgatcgg catgctgttt cccacaaaca gcgagctgtt ttcaggcaca agatgctgaa 2809021 ggattcgata gagattgcct tcaaacgaaa catcttcact gctgattgtt tgcagatgct 2809081 cgcggaaccg cccattgaca aactgccact tttccagcca ctctgaggat ctggtggcag 2809141 cagtaaggcc tgccatgatc tcctcagcaa aaacagacgc attacaatga atcatatgcg 2809201 cgcttgcctg tgtcgggtct ctccaccctc catcctcgtc aatcacgatt tgctgaatcg 2809261 tcggatcatc cttaagccat aagaaaaccg gttttgaaac aggcatcggt ccaaaccgaa 2809321 tgacaacatc aggacggagt ttccgcttca gctcatcatc ttttaaaaac gaatcatacg 2809381 catcaataac agtgctttta tcatgaacac cattccgcag attagacagc ggatctgcta 2809441 aaattggata ctgaagcgct tttgacagcg caataatgtt ttccttgtcc gcatcactat 2809501 ggagctctcc gcagacgatc attccttttt cagcctctgc gagcatctca gccacatcag 2809561 acagggactc tcggtcaaca gactgcgtac ccgttttcac agacacatga cggcctgttc 2809621 tcattcttcc aaacggctca tctgaaagat ccggcatcag cggttcgcgc agcggcacat 2809681 tcacatggac aggccccatc gggcgctttt gtgcttctcc ggcagcgcgg cttgccagcg 2809741 ttcggatgta tctcagcatt tgcggagact cttcaggaag agcagagtct gtgaaaaact 2809801 taacaaagtt accgaataag aagtgctgat taatagcctg cggtgcgcct acttcgcgca 2809861 gctcatgagg ccgatcagca gttaacacaa taataggcac ccttgaataa tgggcttcaa 2809921 ccacagccgg ataaaagttg gccgcggctg ttccagatgt acagatcaat agtacgggac 2809981 gctgcttcgc ttttgccaaa cctaatgcaa aaaatccggc agacctttca tcaatttgga 2810041 catggacgct gatatcggga tgcgcagcac aaagaacagc cagcggtgta gatcttgagc 2810101 ccggacaaac gacggcgtcc gtaattccgg aaagggcgaa ttcatcaata aaacttccga 2810161 tgtaatgagt aatcgggttg actgtcaacg cctctcacct cctaatgcag agatcatcgg 2810221 cttcaattta atctgtgttt cttcatattc cgagattggt tccgagtctt ccacaatacc 2810281 gcacccggca aacagccttg ctgtgcttcc ttcgatgagc cctgaacgaa tggcgaccgc 2810341 gaattccccg ttatcctggc tgtcaatcca gccgataggg gccgcatacc agccgcggga 2810401 catcggttca atctccctga tcacgtcaac agctttttcc tgaggtgatc ccccaagcgc 2810461 gggagtgggg tgcagcttct caattaagtc aaaaatcgaa gcagactcgc gcagctgtcc 2810521 gacaatcggc gtaaacaggt gctgaacgct ttttgttttg tacaaaacag gtccatcagg 2810581 cttttcaacc tctgaacagc ttgatacaaa agcattatga atcataccta ccacaatatc 2810641 atgctcaagc aggtttttct catcgtttaa taattcaagg cctatccggc ggtcgtcttc 2810701 ttcattcacg cctcgtttaa tggagcctgc cagacaggaa gacatgacag tgccgccgtc 2810761 tcttttgatc agtctttccg gagacgcgcc gacaaaggtt ttgccttctt gttcaattgc 2810821 aaaaacatag cttgtctgct gatcgtccag aagcgtttta agcaccggtt caatttggat 2810881 tggaccgtca aacgtgagca gcagctctcg ggcaagaaca accttatcat attgtttctc 2810941 tttaatttgg cttgtggccg tttcgattgc tttcagccaa tcatccttat ccagctcttc 2811001 ggctgctgca atcacagcct gatcttcttg cttgaaatcg ggaaccataa attccgccgc 2811061 aaaagctttt aagccttcta aaacagcttc tgcgtcttct cctccgctta cccatctgtt 2811121 aactgttaag aacgggcctt cagcagtcat cgtcagcata agcgcaggca caaagaaatc 2811181 cccttccgag aaatggtccc attgtgaacc tctttcttcg caagggtcaa aagaaaatcc 2811241 tccgaataac acaggtccca ctgcagaatg ctgcagcttt tcttcttcat aaatatgaaa 2811301 agccgtcttt ttaaagcgct cccattgttc aaaaacctca cgataccgct cgctgttttt 2811361 ttgatttgtc tggaaaaccg cttctttgcc aagaccgact attgtcaatt cactttcagg 2811421 atctgaccaa aaaaatcgat tgcctgtata tttttttgct ccgtaattga aaaatgatag 2811481 agggtcaaga gactcgattt gtctcgaata gcttattaag acagcatggt tgacttcttt 2811541 ggctttatgt aatgcatgta gaacttcctt tcggaacgta cgctgcaccg ttgtcaccat 2811601 gagacattcc tccataatcc ttaaaatgct tttaatacca tacacctgtg tctcctttgt 2811661 gtcaaacaca gatcatgcag tccaaatggc ctgccttacc tattataaac ctaatttcag 2811721 aaatgaaaaa gaaacaaagc ttaaatttct ttctccactg atagcaaagg ttgtatccgc 2811781 ttaccataaa aggaaaacct cctatattcc tccacccgcc atttatgaaa gttctcaggc 2811841 gatctgttca tactaaaggt atgcatcaca gagaaacgag gcgatcacat tgcttacgaa 2811901 agaacagctt cagcatttaa aaaatgaact ggaacaaacg aaaaaagata tcttaaaccg 2811961 tttcaaagac aatgatcatt ttcagcttaa ctcagccttt ccttatgatt cgtggggtga 2812021 gctttcggca tacgacaacc atcccggcga tcaggcgaca gaactttacg agcgtgagaa 2812081 agacatcgct ctagacttgc atgagagaga gcaccttcgg gacattgagc attcattgaa 2812141 ggcgatagaa aacggtacgt atggcatttg tgaagtcagc ggaaaggaaa tccctttcga 2812201 acgacttgaa gcgcttccga ctgccacaac cctcgcggag tattcgtcac aggacgtggt 2812261 ttccaaagac cgtccgattg aagaagaaac accattcggg caatttgaat ttgatgatga 2812321 tgaagaaatc agagcgccat atgacagtga ggattcctat caggatgtcg aaaaatatgg 2812381 gaactcacaa acgccgcagg atatggaaaa ccctccgctc agctatgatg atatgacgat 2812441 gaatgccgaa gagaatatcg gcaatacgga gtcttacgaa aatttcatcg ctacagatat 2812501 cactgggaaa gaaattaccg tttatcaaag cagagcccat gagcgctatg aagaagaact 2812561 tgacgaagag ggaatcatga ccacattcgg cgatctccac gctgattgaa cccccaatta 2812621 ttgggggttc ttttccgttt tcagcatatc gtaaatcagc ttcagataat ccttttgcag 2812681 gccgatgtca taccgctcgc cctctagcaa tttcccgtat acggtacatg ccccgagcga 2812741 agcttttatc gcatccgtta cctgcacttc tcctccgcta tcagcttcta atgcctccag 2812801 ctcattaaaa atatccggtg tgaaaatata acgccctgct gcggcaaaat gagacggagg 2812861 gttttgttta ggcttttcca caatatcctg tatgcgataa agcccttttt caacaggctc 2812921 cccttttatc accccgtaat gatgtaaatc ctccgttttt gtttctttta agccgatcac 2812981 actggactga tatttcgtat acgcttcaat cagctgcccc aaagccggct gattggcgga 2813041 aaaaatcaga tcatctggca aaacgacggc aaaaggctct cctcctgcaa attgctttcc 2813101 gaaagaaatg gcgtcgccaa gaccctttgc ataaggctgc cgcacatagt gaatccgtat 2813161 atccggaatg ggatgctctc taagtaaatg cagtttattc ttagaggcca aaaaagcctc 2813221 aagtgccaaa gaggaatcaa aatagtcgac aatcagattt ttatggctcg atacaaccat 2813281 caaaatgtcc tcaatgcctg actcctttaa ttcttcaaca agataatgaa tcacaggctt 2813341 agatcctacc ggaaacattt ctttcggaat caccttcgtc accggcagat ttctcgtgcc 2813401 gaatccgcct gcaggaatga tcgctttttt tatcatggta ttttcccctc agctcatgtt 2813461 tattacatga tattccaaga gcgcatcccg atgtttgtac atctgaaatt aggcggaagc 2813521 aactgggcag aaagcggaat cacgaaccag ccctttttta ataggatatt gatatatgac 2813581 cagtaatctt gtaaaggagc tcaggtgatg aaaatttgtg tggttggcgc cgggtatgtc 2813641 ggtttaaccc tatcagcggc actggcatcc atcggacatg acatgatatg cacagacaaa 2813701 gacgtcaaaa aaatcgggca gctgaaaaaa ggagtcattc ccttttacga gcctgggctt 2813761 tcagatgcaa tacttcgttg cggcaatctc tcgttttctt ctgaagtgaa atcgagcatg 2813821 gaggaatgtc ccgttatttt tatcgcagtc ggaactccgc cgcgttcgga cggatcagct 2813881 gatacgaaag ccctgcagtc cgtcatcggt gatttaagcg aggcgatccg atcgtataaa 2813941 accattatta cgaaaagcac tgttccgccc gggacaaatg aaaacatagc aaaacagctg 2814001 attgcctccg gagtgtctaa aaacctcttt aatatcgtat ccaatccgga gtttctgcgg 2814061 gaaggcaatg ccttatatga catgctgcat cctgacaaaa cagtcatcgg tgttcaggaa 2814121 gaagatcacg tatcggcagc catcgtcaaa tccatttaca aacacattga tacccctttt 2814181 atcgttacaa gcttagcggg agcagagctg atcaaatatg ccaacaattt ctttttagcg 2814241 gccaaaattt cgttcattaa cgaaatggcc cgcatatgtg aagcctatca atcagatatc 2814301 tcagatattt cccgcgctat cggtctagac ccaaggatcg ggaagcactt tttgcaggca 2814361 ggcatcggat acggaggctc ttgttttcca aaggatctgc aggcgctgca atttgctgcc 2814421 caggaaaaaa acacggagac cttcctgctc cgggccgtgc agcacattaa tgacacccag 2814481 cttggcctgt atatcaaaaa aatacagtca ttcttcgaaa cacttcaagg caagaaagcg 2814541 gctgtactcg gcatttcctt caaaccgaat actgatgaca tccggaattc tcaggctgtc 2814601 agactgatgg aaaggctggc ggagctggga tgtgatgttc atgcatatga tcctgaagct 2814661 gtacttccag aacatttgcg gcaacatgta actcagcatt ctcaagcttt tgatgcgatc 2814721 gaagagagtg actttttatt tttggcgaca gaatggtctg agtttttagc gtttgattgg 2814781 aaaaaggctg cagatatcat gaaagggcgt cttgtgattg acggacgcaa cgtactaaaa 2814841 aaagaactga tcgaggcttg cggcctgatc tgtacgggag ttggccgtcc atgaaaatac 2814901 tcgtcacagg agcagcgggc tttatcggct cccacctctg cgaagaatta ctaaaagata 2814961 agaaacataa cgttatcgga atcgatgact ttatcggtcc tactccattt tccttgaaat 2815021 taaaaaacct taaaaacctg ctgccggaaa agcgatttac gttcataaag gaaaatctgc 2815081 tgacagccga tcttgcttcc ttactggaag gagtggacgt catctttcat ttggcggcca 2815141 taccgggtgt ccgctcaagc tggggcaatc attttcaccc atatgccgca cataatatcc 2815201 aagcgctcca aaggctcctc gaggcgtgcc gggaacattc tattcaaacg ttcgtctttg 2815261 catccacctc ttccgtctat ggcgaaaaac aaggaaaagt cagcgaaaac acgtcgcttt 2815321 ctcctttatc tccgtacggg gtaacaaagc ttacgggaga aaagctttgc catgtgtata 2815381 aacagagctt tggcattcca attgtgattc tccgtttttt taccgtatac gggccaagac 2815441 agcggccgga tatggctttt caccggctca ttaagcagca ccttcagcaa aagccgctta 2815501 ccatcttcgg tgatgggcag cagtcaagag atttcactta tatcagcgac tgtgtcaaag 2815561 gcatcaccgc tgttcttggg aaaccccacc ttattggtga aacagtaaat atcggcggcg 2815621 cagagcgtgc ctcagtctta aaagttgtct ccctcattga ggatatttcc gggagaaaag 2815681 caacactgca cttttcggac aaaatagcag gggaaccgag caacacgtgg gcggatattt 2815741 caaaagcaaa acagctcttg cattatgatc ccgccacatc cttaaaggat ggcttgacca 2815801 acgaaatcgc ctatttatcg tcgctgtatc agggggaata aaaatgaagc ttgcctttat 2815861 ctgtacagaa aagctgccgg cgcccgcagt acgcggcggc gctattcaaa tgatgattga 2815921 cggtgtcacg ccctatttca gcagcaggta cgacctgacc attttttcaa tagaagatcc 2815981 atcgctccca aaaagagaaa caaaagacgg cgtacattat atccatctgc caaaagaaca 2816041 ttaccgcgag gcggtagccg aagagctgcg agcctcttcc tttgacctca ttcatgtgtt 2816101 caacaggcct ttaaatgtct ctttatataa aaaagcctca ccaaacagca agatcgttct 2816161 gagcctgcat aacgaaatgt tttctgaaaa aaagatgacc ttcgcgcaag gaaaagaagt 2816221 actcgacaat gtctccatga tcacaacagt gagcgaattt attaaacaaa ccgtcattga 2816281 acgtttccct gaagccgagg acatcacaaa agttgtgtat tccggcgttg atttaaactc 2816341 ttatccgccc gtctggacga tgaaaggctc ggctgtcaga aaaacatacc ggaaaaaata 2816401 cggtattgaa gataaaaaag ttattttatt cgccggccgc ttaagcccga caaaagggcc 2816461 tcaccttctc attcacagca tgagacggat tttgcagcag caccctgatg ctgtactggt 2816521 catagcaggc gggaagtggt tcagcgatga cagcgaaaac caatatgtca cctatctgcg 2816581 cacgctggcg ctgccataca gagaccacat aatctttaca aaattcattc ccgcagacga 2816641 tatcccaaac ctttttctga tggcagatgt atttgtgtgc agctctcagt ggaacgaacc 2816701 cctcgcccgt gtgaattatg aagcaatggc ggccggcacg cccttaatta ccacaaaccg 2816761 gggcggaaac ggtgaagtcg taaaacacga agtcaccggc cttgtcatcg atagctacaa 2816821 caaaccttct tcatttgcaa aagcaattga cagagccttt acagatcaag aattaatgaa 2816881 caaaatgaca aaaaacgccc gaaagcatgt agaagcttta tttaccttta cccatgctgc 2816941 caaaaggctc aatactgttt accaatccgt tctgaccccg aaaaacaaac aatttccgcc 2817001 gccttttctg acgcaaaatt ttgatttatc atctatcaat cagctttttg tgaaagcaaa 2817061 aacataaaac ctacagctcg tgttgcaaaa cgggctgttt tttcgctaca gagaacttaa 2817121 aaaaaggcat aaatgtgact ttatgccttg cgctttacag tttgagaaaa ccatggagct 2817181 ggtttagatt cacttggaag aatgatgatt tccactttag cttcttccgc taagtctggt 2817241 tcttcatctt catcctcttc ttcatatggg ggcgctgagc gtttcgaatc acgctcctcc 2817301 tcaggctcca gagtggtttc gaattttgtt tcttcttcat catcgacgat tttgcgatct 2817361 gtttcctttt ccttcgtttc tttttgatat tctttcggtg cattgatgtg agggagctct 2817421 cgaatgctgc ccacatctaa atgcttctcc tcttcttcct tctcagctga gattgagtca 2817481 tgagcctgcc atcccatcgg tccaggcggt gtaaatacga attggtcgag atccagttta 2817541 gaaatagagg ctttttgtct cgatgacctc atgtcaattc gcctcccgat acgcttttat 2817601 ctttttatac agttccggca gtttatccaa aaacgaatct ttagattctt caacagaaat 2817661 catgttttgc agcgcccagt tatacttctc atctgaccac gttttctttt gcttcaaata 2817721 atatttgtgc ccgattgcac agaacaaatg cggaaacgcg agatcaatcc aaagtacctc 2817781 gtactgtttt tctgtgagcg gatacactgc gtcgtaggcc gcaagcagtg caaccatgaa 2817841 atcagtatcc catacagaaa gcttaaccat cactttattc agcagaatac gaaggtctct 2817901 tgacggcaaa tcgtaggtaa tcgagtgaag ctcctttaaa aaaggctccc cttcgatctc 2817961 agtcaaacgt gccaatgtaa aatcctgaaa acagaatccg ccatgctcga gtgtctcttt 2818021 tgtccaggtt tcgtattctg agtcatcaag cgctctgaga gcttcttttc ctcttgccag 2818081 cattttatca gcatgtttta agaaagtttg cgaaaatacg tcatcaggat aggatgctgc 2818141 gatctgcata ttcccttcaa gttcctgcag cttccaacgg tacaatttgt gccattttcc 2818201 cagcctgctt ctcttcttgc tttcatctgt gcaaacatat ccttttgagg catgatgaaa 2818261 atggccggca aatgacatga cttttttcat ttgctctgca tcatagtaaa tcatttcttt 2818321 tcctgtcact ttgtcatata aactgtaaga aacctgatcc gtgcccaagc agctaccgcc 2818381 attttttgtt tgatgaatcg gcgctatcgg cagccctttc tcttgtaaat gggcgtgtgc 2818441 ctgagtgata aaaagcatcc gctccggttt catttgcgct tcttttagca gctttgggcc 2818501 atgatcagtt tcgacttccc agattttgcg cccgcttttg ttcgatttca gcgccacatg 2818561 gtcgatatga aacggataat aactgagaat ttcggacaca atctgttctt catgctcttt 2818621 ttggtacact ctgttcaccc cttctatctg ttcttttcat agacgctgag cagattttca 2818681 gccaccctct gccagccaaa attgctttct gcctcacggc ggctgtattt cccaagccgt 2818741 tcccgctttt ccgagctgct cagcaaatca ttgatacgtt cggcatattg tttaggattt 2818801 tcaaagtcat gaatgatgta gccgtttttc ccttcctcta tgacctctgg attgcctccc 2818861 cgattgcttg taataatagg aagtcccgca gccatcgctt cataatgcac ccttgctaaa 2818921 ggctcctgcc attgcgaaga gcatacaaat acatctgaca tggtataaag gcgcggaatg 2818981 tcctttggct tcacaaattg aataaatgtg acatgatcct tttgcatcgc accaagggta 2819041 tgaagatgtt tgacatagtt atttaattca ttatctccga accattttga cccgataaac 2819101 accatcatga catcggggtg ctcctcaatg atgtccggca aagcctgcaa taatatgtgc 2819161 gggcctttga ctttgctaag ccggccgaca aacaagacga tttttttgcc gtgaagcccc 2819221 agctcgcttc gcatctcttc gcgagctcgc tgcccttcat tcgtccagcg agggtggtac 2819281 gtttttaaat ccacaccaga atacaccgtt tttgtttttg atcgtgctga cggaaaacgg 2819341 cttgtgatcg tctgtccgat ataatcgctg accgtaacaa tctgcgctac ggagtcgatg 2819401 caaatctcgc cttccgcctg gctgatttta tcgtaagcga acatttcatt gtgaacgctt 2819461 aaaataaaaa cagcatccgg cgcctgtttc ttcaatttcg gaacccagct tgggcgatta 2819521 caaacatgca caagatcaaa acggctcttt ttcagctctg ctccaacggc ttcttcataa 2819581 cggtcttcat ccaaatgcac ataatggaca ccgtctacct tctctctatc agcgagattc 2819641 ggatctttaa tagaaaacac agtcacctca tgtttttttg caattaaagg ggcaaccgct 2819701 tcgaggtaga tttgaatggc gcctcctcga accgatggga caggaagctt ctctgtggcg 2819761 atcagtgcta ttttcataca tagcctccat tcctgcatga tttttaacta gttagaatca 2819821 tgatacggct gaacaaccaa cttgtgcgga atgggactgc cctaaaaaca aaacgggtaa 2819881 acaaccagat tcatctatta aatatagtca aataactcaa tcattttttc cttttgattc 2819941 ataaggtagg agtaaaacag gtaaggatgt gtcctttaat ggcagaaaac catgaagtca 2820001 ttgaggaggg gaattcatca gagcttcctt tatcagcaga agatgcaaaa aaattaacgg 2820061 agctggctga aaatgtgctt caaggatggg atgtgcaggc tgaaaaaata gacgtcattc 2820121 agggaaacca gatggcgctt gtctggaagg tccacacaga ctccggcgcg gtttgtctaa 2820181 aacgaataca caggccagaa aagaaagcgt tgttttccat tttcgcgcag gactatttag 2820241 caaaaaaagg catgaatgtt cctggcatac tcccaaacaa aaaaggcagc ctatattcta 2820301 agcacggctc atttctattt gtcgtatatg actggatcga aggaagaccg tttgagctga 2820361 ctgtaaagca ggacttggag tttatcatga aaggccttgc tgattttcat acagcttccg 2820421 tcggatatca gccgccaaat ggcgttccca tatttaccaa attaggtcgc tggccgaatc 2820481 actacacgaa acgatgcaaa cagatggaaa cgtggaagct gatggcggag gcggaaaaag 2820541 aagatccttt ctcacagctt tatcttcagg agatagatgg ctttattgaa gacgggctgc 2820601 gcatcaaaga ccggcttttg caatcgacct atgttccatg gactgaacag ctgaaaaaaa 2820661 gccctaacct ttgccaccag gattacggaa ccgggaatac actcttagga gaaaatgaac 2820721 agatttgggt catcgactta gataccgtat catttgatct gcctattcgc gatttgcgca 2820781 aaatgattat tccgcttttg gatacgacgg gtgtttggga tgacgaaaca tttaatgtca 2820841 tgctgaacgc atacgaatcc agagccccat taactgaaga acaaaaacaa gtcatgttta 2820901 ttgatatgct gtttccttac gagctttacg atgtcattcg cgaaaaatac gtccgcaagt 2820961 ctgctttacc gaaggaagaa ttagaatcag cttttgaata tgaacgcatt aaagcaaacg 2821021 cattgcggca gcttatttaa gaccatcatt tcccccgcat atcgggggtt tgatatttat 2821081 aagataaagg gtaattaaat acatgcggag gttgcaaata tgaaaaagat tgtcggcgct 2821141 ttagccgttt ttgtgattac atatgcgctg ttttcagccg caggctacct gtttcctgtg 2821201 gaccaagaat ggtacaattc attgaaaaaa ccggactgga cgccaagcgg aactgcgatc 2821261 ggcatcattt gggccatcct gtttgccctg atctcccttt cagcagccat tgtatatgct 2821321 gcgttttcat ttaaaggtgc gaaaagcttt tggtttacac ttttgataaa ttacgtgctc 2821381 aatcaagcct tcagctattt ccagtttacg caaaaaaatc tgctggctgc atcgcttgac 2821441 tgcctgcttg tcgccatcac agcaatcgta ttactgatca ttgccaaaaa atacagcaga 2821501 gccgcaagct atcttctttt gccttatttt ttatggagtg catttgcgac gttcttatcc 2821561 tttacaatca attcaatgaa tctgtgaaca aaaaaagccg cttatacagc ggctttttca 2821621 catcatcggc ttgatgcccc aaatgtcctt cgcatattcc cggatcgtgc ggtcgctgga 2821681 gaaatatcca gaatgagcaa tgtttacaat cgaatgctca gaccatttcc ttcgctctcg 2821741 ataatcagct tgaattcgct cctgtgcatc tgcatatgag ctgaaatcct tcagcacaaa 2821801 atactcatca ttatgcggaa gcagcgagtc aaagatcgat tcaaattcat ctgcctctcc 2821861 ttcaaaaaaa ccattgatca actgatccgc tacctgcctg attctcctgt catgctgata 2821921 atattccctc gacctatagc cgccgttttc ctgatacgat agaacctcat ccgcctttaa 2821981 gccgaacgtg taaatacagt cagggcccac ccgctcaagg atctcgatat ttgcgccgtc 2822041 atgcgtgccg atcgtcaaag ccccgttcat cataaacttc atattccctg taccagacgc 2822101 ttccttgctt gcggttgaaa tttgctcact tacgtctgat gccggaaaaa ttcgctcagc 2822161 catagaaact ctataatttt ctaaaaaaac aactttgatc agctgtttga ccgccggatc 2822221 ataattgact ttttctgcga cagaatggat cagcttaatg attttcttgg cataataata 2822281 gcttggtgaa gcctttgccc cgaaaataaa ggtttgcggg tagattgaaa accccgaatc 2822341 ctccttgagg cggttataca aatacataat gtgaagaaca ttcagcagct gccgtttata 2822401 tgcatgaagc cgtttcacct gtacgtcgaa tatgctctca gggttcacaa ccaccccggc 2822461 cgtgcaaaaa atcaaatcgg caagctcttg ttttttcttg cttttgttgt tttgaaactg 2822521 ttcaataaat gcaggatcag tggcgtacgg ttctaaacgg atcagtgatt ccggctgctt 2822581 gacccattca tcgccgatcg cctctgtaat gatggcagac aagcctggat tcgcttttaa 2822641 cagccagcgc ctgtgggcaa ttccattcgt cttattgtta aaacgattcg gaaacagcaa 2822701 gtgaaagtcg cgcatctccc tttcctttaa tatatcggaa tgtatttttg caacgccatt 2822761 tacactgtag ctgcctacta tggccagatg agccattttg acaacaccat gcgctgtaat 2822821 cgccatgttc tctatccttt tccagtctcc aggatacttt tcccaaactg cacggcaaaa 2822881 cctctcattg atctcttcaa taatcatgta cattcgcggg agcagcggct taaacaaatg 2822941 aatcggccat ttctcgagcg cttctgacaa tgttgtatga tttgtataag aaatcgtatg 2823001 tacagtgata tgccaagctt cttcccagct catgttctct tcatcgagca aaatccgcat 2823061 tagctcaggc accgcaagcg cagggtgagt gtcattaata tgaatgctca cttttttatg 2823121 caggccggat aaagatttat gtgttttacg gtaattgttc acaatgcttt ttaagcttgc 2823181 gcatactaaa aaatactgct gcttcagccg taaaattttc ccctcatcat gggtgtcatc 2823241 gggatataag aattcagaaa ccgcttctgt ttctcgctta taagacaaaa tattaccgcc 2823301 gtgataatgg gcatagggct cggcgttcca aagccttaac gtgttgacag tgcccgtttc 2823361 atagccgatg atcgggatat cataaggaac agcggtaaca attgtcgctt gttcatggcg 2823421 aaaatgcagg cgcccgcttt tttctgtcat atggacttcg ccccaaaacg gcacgtccac 2823481 tgcttgatcc gcattcctta cttcccatac gttcccgttt ttcagccatt gctcaggcag 2823541 ctccacctga tgtccgtcta caattttttg ctcaaacaaa ccatgcttat aacgtatgcc 2823601 catgccgtgc ccaggcaggt tcaacgaagc aagcgaatct aaaaagcaag cggccaagcg 2823661 cccaagtccg ccattgccga gacctgcatc gttctctatc tgaaggatct cctctaaatt 2823721 gatgccgatt tcctttaaac cagcttctac aacatcacga acaccaagat tcattaagtt 2823781 ttgctcaagg agctgaccga gcagaaattc gattgataaa taatatgtct gcttcccgga 2823841 atttgatctg cttttttcat tcgtttcgat ccaatcagcg ctgatatact ctctgaccat 2823901 attgcccaac gttttatatt gatccagctt ggcagaatct ttaaagcttt ttccgcacgt 2823961 catttccaga cgctttaaaa ataagtctgc aaagcgttct ttactcgaga acatcccgtc 2824021 cactccttgt cacctgctcg aaaatacgct gatactcttt agccgacttc ccccagctgt 2824081 aatctgcatt catagcggtc ttcacgatgc tcttccatac atcctgttgg caataaaacg 2824141 acagcgccct ttctatcgta aatttcagat catgcgcatt aaaggcggaa aacgtaaagc 2824201 cattgcccgt tccctcttcc tcctgatagg cacggacagt gtcgtaaaga ccgcccgttt 2824261 ccctgacaat cggaatggcg ccatattgaa gagcaatgag ctgccccaaa ccgcacggct 2824321 caaatttcga cggcatcaaa aacatatcag agcccgcata aatttgatgg gctagcggct 2824381 catcaaaccc gatataagcc cggcacttct catgaaaagc aaattctgca taccggaaat 2824441 aatcttcaaa ttcacgttct cctgtgccta gcacaaccag ctgtatgtct tgctcctcaa 2824501 gaagttcgtg cataattctg cggacaagat caagcccctt ttgtttagtg agccttgtca 2824561 ccatactgat cagcggaata tcgtttttct ctggaagccc catccgctgc tgaagcttcg 2824621 ttttgttttc cagcttgcat gcaagatccc ctgaatcgta ttgcgcctct atataagggt 2824681 cgcttttcgg ctgatagaac gtatcatcaa tgccatttaa tatgccggtt acatcatctt 2824741 ccctatattg caaaacctgt tccaactgct caccataata cggcgtcatg atttcatttc 2824801 tgtaagtggg gctcacagtt gtcacatgat cagccgcaat gatgcccgct ttcataaaat 2824861 taacaaatcc gttgcattct aacctttcat aatgaaaatg atccatctca agacccagca 2824921 agtcatgtgt gacatcagga gggaatatgc cttgaaactg caggttgtgg atcgtgagca 2824981 cgcttttcat ccgttcataa aaaggatgtt ttctgtactc ctctttcagc aaataattga 2825041 ccatcgctgt atgccaatcg tgagtatgaa caatatcggc ttgaacattc acaactttgg 2825101 cagcctccag cacagctctt gaaaaaaagg caaaccgctc accgtcatca taatgcccgt 2825161 acaacgaatc cctgttgaaa tagtactcat tgtcgatgaa gtaataattc acatcattct 2825221 ctgccatatg ttcaattccg caatattgct gccgccagcc gacagctacg gtacactcag 2825281 cctgtttttt catacgcttt ttccacggtt caggtatttg gctgtacttc ggcagcatca 2825341 cagctacctc attgcctaat cgcgcaagcg cctttggcag agcacctgct acatcggcaa 2825401 gacctcctga tttcacaaat ggggtgcatt ctgacacagc aaataatatc ttcaagaatt 2825461 catcagctct ccttgcacca aaccttttct taatacaagc ggctgctcag ctgttcctgc 2825521 agcttccgtc gccttgccga ttttaacatc cttatccgaa atgacctgct caagaagaca 2825581 atcctctcca atctgcgttt tttgcataat aatgcagttt ttcagcttcg taccctttcc 2825641 gacatggacc gccctgaaca aaatgcagtt ttcaacctct ccttcaagca cacagccgtt 2825701 tgccaccaaa gaatttttga cagtgctgtg ctttccgtat ttcgtaggcg gctcatcctt 2825761 cacttttgta tagatcggct gctgcggcaa aaacacctgc tgccaaaaac gaggctgaat 2825821 gagctccata ctgtgggtat aatatttttc caccgaatca atgacagcgg cataacctga 2825881 atattcataa gggcaaatgg tcagggcgga agattccttt tcaacagcct cctgaatggt 2825941 tttatagcct ttttcgctat gtccgtagat cagatccttt aaaagcgttg ttgacatgat 2826001 atagatttgc agcgactggc cgtcctgaaa tacctcggtg acgtcgcagc caacctcctg 2826061 atggcgtttc agcacatatt gaaattgaat gttgcatacg gtatggctgt tggagattac 2826121 agcatattgc tgagtgcttc tgtggaagta atctagatgg tccgaaaact ggcgaaagga 2826181 accgaattca tcgtattcgt gatgaagatg gggagacggg aaaaaaaaga ggccgtcctt 2826241 tttccggtgc aaatcccatt ccttacccgc cccaaggtga tccatgagcg aacggtaacg 2826301 atacttcgga aaaattgcaa cactcctaat atccgcattc accatgttgg aaagcataaa 2826361 atcaatcagt cggtacctgc cggcaaaagg gatcgccccg agcgaccgct gtgctgttaa 2826421 atcctgaaga gaatgcttat atgtggtttc atctataaca cctaacattt gattattgaa 2826481 cactgactct gccccctctt cagtaattaa atcaattctt tttctacaaa ttcctctgaa 2826541 acgagcagca cctcttcaat gtctttttcg gagcgaatca ctgcgccatc cggcagcacc 2826601 atcccattag gaacgatggc attttcaatg actacatgct ccccaatcgt cacatccggc 2826661 attatgacgg atgatgtaac agtcgtatgc ttaccaacag tcacaccttg aaaaagaacg 2826721 gagtgagaca catttccata tacaacacaa ccttcgttca caagcgaatc ttgaacctgc 2826781 gcatcagatg aaataaattg cggaggctga tttggattga cggagtaaat tttccatttg 2826841 cgttcaaaca gcttcagctc cgagtcctct tttaacaaat ccatattggc ttcccacaag 2826901 ctctgcaccg ttccgacatc cttccaatat cccttgaacg gataagcaga aagcttcttt 2826961 ttctcttcca aaagcagtgg aataatgtct ttgccgaagt cgtggctaga ataagggttt 2827021 tgatcgtcca tctcaagata ctgtttcaaa agcggccaat tgaatatata aattcccatt 2827081 gaggcaagat tgctcttagg gaatttgggc ttttcatcaa aatgtgtgat cgtcccatct 2827141 ggattggcct tcatgatgcc gaaccggctt gcttcctccc agcccacttc gatgacagag 2827201 atggtcacat ctgctttctt ttcaatgtga taatcaagca ttttgccgta gtccattttg 2827261 tatatgtgat ctcctgataa aatcagtaca tactcaggat catactgatt caaataattg 2827321 agattttcat aaatggagct tgccgtccct ttataccatt tgacttctga tgactcggca 2827381 taagggggta aaaccgtcac gccgccatta tatctatcca ggtcccatgc actgccgatc 2827441 ccaatatagg aattcagctc gagcggctga tattgcgtta aaatcccgac tgtgtctatg 2827501 cctgaattag aacagttgct tagggtaaaa tcaataatcc tgtattttcc cccgaaagat 2827561 acagccggtt tggccatatt ttttgttaat ccgctgagac ggctgccctt cccgccggca 2827621 aggagcatgg ctacacattg ttttttcatc tttttatctc tcctcttttt ttaaccgccc 2827681 gtaaaatcga gatgccgtaa ggggggatgg tcatcgtgat ataacacggt ttatgatgaa 2827741 gtgctccctt tttagccgat aacggctttt tgttgatttg ccctgagcct ccatatgttt 2827801 cactgtcact gttaagcact tcaatgtatt gagtaaaaaa aggaactcca acatcatatt 2827861 gatgatagac cacgggtgta aaattacaaa tgatgacaag cgcctcaccg tgcttttggc 2827921 cataacgaat aaaagaaaag attgattgtt cgtcattatg gacatcaatc cattcaaacg 2827981 attgtgcacg atggtcatgc tcataaagga ttttgctttt ttggtaaaag cggagaagat 2828041 cttgcgtaaa aacgctggct ttctgatgca tggggaagga gtccaaaaac caatcaagct 2828101 gttctgtatc tttccattca tcaaattgag caaactctga tcccataaag atcaatttct 2828161 ttccgggatg cactgtcata tagcccagca aaagccgata ctgggcaaat ttctgccagt 2828221 agtcgccagg cattttattg agaagtgatt tttttccgta tacgacttca tcatgagaaa 2828281 acggcaatac aaaatgttca ctaaacgcat atagtaatga aaaagagata agctgatgac 2828341 aatgccgcct ttcttcgggc ggcgtctcca tgtatttcag tacgtcattc atccatccca 2828401 tattccattt ataatgaaaa ccaagccccc cttcctcaac ggcacctgtc acttgaggcc 2828461 attctgtaga atcttctgca atcatcatca catggggata tgcctctctc atggtttgat 2828521 tgagtttttt taaaaaatca acagcatatg gattcgtgtg gcgttcatcc tgatttggcc 2828581 aatacaagat attagccact gcatcaaccc taaatccatc tatatgatag aattccgccc 2828641 agtacaacgc attcgaaatt aaaaaactat gaacttccgg tttccccagg tcaaagtttg 2828701 ccgtgcccca taaccagttc tcccgatcac gttcttcttt gtattcataa agcggttctc 2828761 catcaaacat ataaaggcca tgtgcatctt tacaaaaatg tccggggacc caatccaaaa 2828821 tgactccgat attttgttga tgacattcat ccacaaactt catcagatca tgcggcgggc 2828881 caaacctgct tgtcgggctg taataccccg ttccttggta cccccatgaa cgatcatatg 2828941 gatgctcata cacgggaagc agttcaatat gggtaaaccc atgcttcttg atataaggga 2829001 taagcgtctg acttaattct ttataggaat aatgcctgcc atcagaatgc ttcttccaag 2829061 acccaagatg cagttcataa atgaaaacag gtttttcata cagcgtctta gccttctgtt 2829121 tcttttgcca tttttgatct tgccagctgt atccttccaa atcgtaagta agtgacgctg 2829181 tgtttggtct gacttctgaa taaatagcgt atggatctgc cttcagcctg atctcaccgt 2829241 tattcgtcac aatttcgtat ttatatcgtt ccttttctcc tatacctgga ataaataacg 2829301 tccaaatgcc attatcattc actctgtgca tcacatgctc ttctccagac cagctgttaa 2829361 aatctccagc cactcgtact tccgacgcat gaggcgccca cacacagaat tcatatccgc 2829421 ttttgccatt cagctcgcgg taatgcgagc caaacagctg atagctttta aacagactgc 2829481 cttcgtgaaa aagataaaca tcatgtgctg tcgggctggc agcggccatg taatcatcct 2829541 ttctgacatc atagttttca tttatagtat ttattcgaag aaataaaaaa aagccctttc 2829601 ctgaaagcgc ttatacttat agacaattaa cttcattttc tgaagaaaaa cgaaatatat 2829661 ggagattttt gtagtctgtt tttaaaataa agaacaaaat ctaagacata tcatgattta 2829721 taaaaacaaa aaaaccttgc aggatatgca aggcttctgg atgacccgta cgggattcga 2829781 acccgtgtta ccgccgtgaa agggcggtgt cttaaccgct tgaccaacgg gccgataatt 2829841 atgatatctg taatcatatg gcggagaagg agggatttga accctcgcgc cgcttacacg 2829901 acctacaccc ttagcagggg cgcctcttca gccacttgag tacttctcca tttggctcca 2829961 caggcaggat tcgaacctgc gaccgatcgg ttaacagccg atagctctac cactgagcta 2830021 ctgtggaaca aaagtcatgg tgggcctgaa tggactcgaa ccatcgacct cacgcttatc 2830081 aggcgtgcgc tctaaccagc tgagctacag gcccatgacg atatagaaat ggagcgggtg 2830141 atgggaatcg aacccacgac atcagcttgg aaggctgagg ttttaccact aaactacacc 2830201 cgcaattttt atttggggcg attgatggga atcgaaccca cgaatgccag agccacaatc 2830261 tggtgcgtta accacttcgc cacaaccgcc aaagcatatt gataaatggt ggctcgggac 2830321 ggaatcgaac cgccgacaca cggattttca gtccgttgct ctaccaactg agctaccgag 2830381 cctaagtatt taaatggcgg tccggacggg actcgaaccc gcgacctcct gcgtgacagg 2830441 caggcattct aaccaactga actaccggac cattttaaaa tttggttgcg ggggcaggat 2830501 ttgaacctgc gaccttcggg ttatgagccc gacgagctac cgaactgctc caccccgcga 2830561 tgattaggaa tatgtatggc ggaggaagag ggattcgaac ccccgcgggc tttgacaccc 2830621 ctgtcggttt tcaagaccga tcccttcagc cagacttggg tattcctccg tatagtggtg 2830681 gaccttgtag gactcgaacc tacgaccgga cggttatgag ccgtctgctc taaccaactg 2830741 agctaaaggt ccattggtag cggcggaggg gatcgaaccc ccgacctcac gggtatgaac 2830801 cgtacgctct agccagctga gctacaccgc caaatatttt tgaaatcaag tggagcctag 2830861 cgggatcgaa ccgctgacct cctgcgtgca aagcaggcgc tctcccagct gagctaaggc 2830921 cccaagaatg gtcgggaaga caggattcga acctgcgacc ccatggtccc aaaccatgtg 2830981 ctctaccaag ctgagctact tcccgatttc atatagatca tggcgcgccc gagaggagtc 2831041 gaacccctaa ccttttgatc cgtagtcaaa cgctctatcc aattgagcta cgggcgcaaa 2831101 acttaatgcc gagggccgga cttgaaccgg cacggtagtc acctaccgca ggattttaag 2831161 tcctgtgtgt ctgccaattc caccaccccg gcgtggatgg tatagttgga gcggaagacg 2831221 ggattcgaac ccgcgacccc caccttggca aggtggtgtt ctaccactga actacttccg 2831281 cagaaatggt gcggatgaag ggacttgaac ccccacgtct gtaaagacac tagagcctga 2831341 ttctagcgcg tctgccaatt ccgccacatc cgcaacatgt aaatggtgag ccatgaagga 2831401 ctcgaacctt cgaccctctg attaaaagtc agatgctcta ccaactgagc taatggctct 2831461 tcttacaata gacttgaata ttatatcata taaaagtggt gccggcaaga ggacttgaac 2831521 ccccaaccta ctgattacaa gtcagttgct ctaccaattg agctacaccg gcatatatgt 2831581 aaaaccgata tgtataatga aaaatggtgg aggatgacgg gctcgaaccg ccgaccctct 2831641 gcttgtaagg cagatgctct cccagctgag ctaatcctcc atacttgcac taacgtgcaa 2831701 ttgcttggcg gcgtcctact ctcacagggg gaaacccccg actaccatcg gcgctgaaga 2831761 gcttaacttc cgtgttcggt atgggaacgg gtgtgacctc ttcgctatcg ccaccaaaca 2831821 aattgagagt gttctctcaa aactagataa caggtgtgac atcattcaaa aatatggtta 2831881 agtcctcgat cgattagtat ctgtcagctc catgtgttgc cacacttcca cctcagacct 2831941 atcaacctga tcatctttca gggatcttac ttccttgcgg aatgggaaat ctcatcttga 2832001 ggggggcttc atgcttagat gctttcagca cttatcccgt ccgcacatag ctacccagcg 2832061 atgcccttgg cagaacaact ggtacaccag cggtgcgtcc atcccggtcc tctcgtacta 2832121 aggacagctc ctctcaaatt tcctgcgccc gcgacggata gggaccgaac tgtctcacga 2832181 cgttctgaac ccagctcgcg taccgcttta atgggcgaac agcccaaccc ttgggaccga 2832241 ctacagcccc aggatgcgat gagccgacat cgaggtgcca aacctccccg tcgatgtgga 2832301 ctcttggggg agataagcct gttatccccg gggtagcttt tatccgttga gcgatggccc 2832361 ttccatgcgg aaccaccgga tcactaagcc cgactttcgt ccctgctcga cttgtaggtc 2832421 tcgcagtcaa gctcccttgt gcctttacac tctgcgaatg atttccaacc attctgaggg 2832481 aacctttggg cgcctccgtt accttttagg aggcgaccgc cccagtcaaa ctgcccacct 2832541 gacactgtct ccccgcccga taagggcggc gggttagaag gtcaatacag ccagggtagt 2832601 atcccaccga tgcctccacc gaagctggcg ctccggtttc caaggctcct acctatcctg 2832661 tacaagctgt accaacattc aatatcaggc tgcagtaaag ctccacgggg tctttccgtc 2832721 ctgtcgcggg taacctgcat cttcacaggt actataattt caccgagtct ctcgttgaga 2832781 cagtgcccag atcgttgcgc ctttcgtgcg ggtcggaact tacccgacaa ggaatttcgc 2832841 taccttagga ccgttatagt tacggccgcc gtttactggg gcttcaattc gcaccttcgc 2832901 ttacgctaag cgctcctctt aaccttccag caccgggcag gcgtcagccc ctatacttcg 2832961 ccttacggct tcgcagagac ctgtgttttt gctaaacagt cgcctgggcc tattcactgc 2833021 ggctctctcg ggcttgcacc ctaacagagc accccttctc ccgaagttac ggggtcattt 2833081 tgccgagttc cttaacgaga gttctctcga tcaccttagg attctctcct cgcctacctg 2833141 tgtcggtttg cggtacgggc acctctcacc tcgctagagg cttttcttgg cagtgtggaa 2833201 tcaggaactt cgctactata tttcgctcgc catcacagct cagccttatg ggaaacggat 2833261 ttgcctattt cccagcctaa ctgcttggac gcggatatcc aataccgcgc ttaccctatc 2833321 ctcctgcgtc cccccattgc tcaaatggtg aggaggtggt acaggaatat caacctgttg 2833381 tccatcgcct acgcctttcg gcctcggctt aggtcccgac taaccctgag cggacgagcc 2833441 ttcctcagga aaccttaggc attcggtgga ggggattctc acccctcttt cgctactcat 2833501 accggcattc tcacttctaa gcgctccacc agtccttccg gtctggcttc acagccctta 2833561 gaacgctctc ctaccactgt tcgaagaaca gtccgcagct tcggtgatac gtttagcccc 2833621 ggtacatttt cggcgcagag tcactcgacc agtgagctat tacgcactct ttaaatggtg 2833681 gctgcttcta agccaacatc ctggttgtct aagcaactcc acatcctttt ccacttaacg 2833741 tatactttgg gaccttagct ggcggtctgg gctgtttccc tttcgactac ggatcttatc 2833801 actcgcagtc tgactcccaa ggataagtca ttggcattcg gagtttgact gaattcggta 2833861 acccggtagg ggcccctagt ccaatcagtg ctctacctcc aagactctta ccttgaggct 2833921 agccctaaag ctatttcgga gagaaccagc tatctccagg ttcgattggc atttcacccc 2833981 tacccacacc tcatccccgc acttttcaac gtgcgtgggt tcgggcctcc attcagtgtt 2834041 acctgaactt caccctggac atgggtagat cacctggttt cgggtctacg accacgtact 2834101 catgcgccct attcagactc gctttcgctg cggctccgca tcttctgctt aaccttgcac 2834161 gggatcgtaa ctcgccggtt cattctacaa aaggcacgcc atcacccgtt aacgggctct 2834221 gactacttgt aggcacacgg tttcaggatc tctttcactc cccttccggg gtgcttttca 2834281 cctttccctc acggtactgg ttcactatcg gtcactaggg agtatttagc cttgggagat 2834341 ggtcctcccg gattccgacg gaatttcacg tgttccgccg tactcaggat ccactcagga 2834401 gagaacgaag ttttgactac agggctgtta cctcctatgg cgggcctttc cagacctctt 2834461 catctacctc gttcttttgt aactccgtac agagtgtcct acaaccccaa gaggcaagcc 2834521 tcttggtttg ggctgatccc gtttcgctcg ccgctactca gggaatcgca tttgctttct 2834581 cttcctccgg gtacttagat gtttcagttc cccgggtctg ccttctcata tcctatgaat 2834641 tcagatatgg ataccactcc attacgagtg gtgggtttcc ccattcggaa atctccggat 2834701 caaagcttgc ttacagctcc ccgaagcata tcggtgttcg tcccgtcctt catcggctcc 2834761 tagtgccaag gcatccaccg tgcgcccttt ctaacttaac cgttaaaaag aatcactatg 2834821 tgatatcttg tgttactaat tgaatgtgat gtctactgtt atctagtttt caaagaacac 2834881 gtttcgaagg aatgatcctt caaaactaaa caagacaggg aacgttctgt ttataagacc 2834941 ttgggtctta tattccgtat aatatcctta gaaaggaggt gatccagccg caccttccga 2835001 tacggctacc ttgttacgac ttcaccccaa tcatctgtcc caccttcggc ggctggctcc 2835061 taaaaggtta cctcaccgac ttcgggtgtt acaaactctc gtggtgtgac gggcggtgtg 2835121 tacaaggccc gggaacgtat tcaccgcggc atgctgatcc gcgattacta gcgattccag 2835181 cttcacgcag tcgagttgca gactgcgatc cgaactgaga acagatttgt gggattggct 2835241 taacctcgcg gtttcgctgc cctttgttct gtccattgta gcacgtgtgt agcccaggtc 2835301 ataaggggca tgatgatttg acgtcatccc caccttcctc cggtttgtca ccggcagtca 2835361 ccttagagtg cccaactgaa tgctggcaac taagatcaag ggttgcgctc gttgcgggac 2835421 ttaacccaac atctcacgac acgagctgac gacaaccatg caccacctgt cactctgccc 2835481 ccgaagggga cgtcctatct ctaggattgt cagaggatgt caagacctgg taaggttctt 2835541 cgcgttgctt cgaattaaac cacatgctcc accgcttgtg cgggcccccg tcaattcctt 2835601 tgagtttcag tcttgcgacc gtactcccca ggcggagtgc ttaatgcgtt agctgcagca 2835661 ctaaggggcg gaaaccccct aacacttagc actcatcgtt tacggcgtgg actaccaggg 2835721 tatctaatcc tgttcgctcc ccacgctttc gctcctcagc gtcagttaca gaccagagag 2835781 tcgccttcgc cactggtgtt cctccacatc tctacgcatt tcaccgctac acgtggaatt 2835841 ccactctcct cttctgcact caagttcccc agtttccaat gaccctcccc ggttgagccg 2835901 ggggctttca catcagactt aagaaaccgc ctgcgagccc tttacgccca ataattccgg 2835961 aaaacgcttg ccacctacgt attaccgcgg ctgctggcac gtagttagcc gtggctttct 2836021 ggttaggtac cgtcaaggta ccgccctgtt cgaacggtac ttgttcttcc ctaacaacag 2836081 agctttacga tccgaaaacc ttcatcactc acgcggcgtt gctccgtcag actttcgtcc 2836141 attgcggaag attccctact gctgcctccc gtaggagtct gggccgtgtc tcagtcccag 2836201 tgtggccgat caccctctca ggtcggctac gcatcgttgc cttggtgagc cgttacctca 2836261 ccaactagct aatgcgccgc gggtccatct gtaagtggta gccgaagcca ccttttatgt 2836321 ttgaaccatg cggttcaaac aaccatccgg tattagcccc ggtttcccgg agttatccca 2836381 gtcttacagg caggttaccc acgtgttact cacccgtccg ccgctaacat cagggagcaa 2836441 gctcccacct gtccgctcga cttgcatgta ttaggcacgc cgccagcgtt cgtcctgagc 2836501 caggatcaaa ctctccgata aatggatcac aggttaagtt caccgcatcc tgcggcgaca 2836561 cctgtgtgac ctgcgtcgtg caggccctag tttgactgac tacgcacatc gcagtgcgat 2836621 ttttaaaaac tgaattaaca ggtacgtttt gtcttgttta gttttcaaag atcatttcgt 2836681 tacttctcaa tgaagcagct ttactaatat aacattcagc ttcttttttg tcaacaactt 2836741 ttttcaagtt gttttgaagc atctagtttg tgtccgctgt gcatcagcga cgtttaataa 2836801 tataacacct gtatttattt attgcaatag ttttttaaaa aaaatctata aaacaaataa 2836861 actataatcc tcgccatgat ttctaaagcg tgtgtatcat ataagtttct taaaagaaca 2836921 tatacatcag tcatgtgatc ttgttgtttt tttcgttttc ttgtatagta gaaacgaact 2836981 aaatactgat gaccacaagg ggagcattaa agctgagagt gagcggtttc gttctgaccc 2837041 tttgaacctg ttagttaacg ctggcgtagg gatgtggcaa agtcaaatga attgcagatc 2837101 gtaaagcagt gcgtggaact tttctcatcc ttccgcgtgc tgcttttttg ttgtcctttt 2837161 ggttgtctgt caatggaagg agatagatat gaatcaatct aagcaactgg ttcgccttat 2837221 tgaaattgcc attatgacag cggcagccgt tattttagac attgtctcag gaatgtttct 2837281 tagcatgcct caaggaggct cggtctccat catgatgatt ccgatctttt taatttcgtt 2837341 tcgctggggt gtcaaagcag gtcttactac aggtttgttg acaggtctag tacaaatagc 2837401 aatcggaaac ttgtttgctc aacatcctgt acagctattg ttagattaca ttgtcgcttt 2837461 cgcagcaatc ggcataagcg gctgtttcgc ttcttctgtc cgtaaagccg ctgtatcaaa 2837521 aacaaaaggg aaattgattg tttcagtggt cagcgcagtt tttatcggca gtttgctgcg 2837581 ctatgccgcg catgtcattt caggagctgt gtttttcggc agctttgctc caaaaggaac 2837641 accggtatgg atttattctt taacttataa tgcgacttac atggttcctt cattcattat 2837701 ttgtgcaatt gtcctatgtt tattatttat gacagcaccc cgtctgctta aaagtgacaa 2837761 agcgtaaaag taacaatccc ccagcgaatt ccgctggggg atttttcgtt atctgttaag 2837821 aagtgttttt aaagctgaaa gatccggcca gccaagacct acttctttca gccttactcc 2837881 ggcaatttca aagttgtcct ccgctactct ttcaggtgaa taggcctgat aaaatataat 2837941 cgagggattc tgctcaataa cccaaacaaa catacttgaa aaaccatgtt gaagcaaaaa 2838001 ctccgctcct tttgctaaga gcgccctgcc tgcaccttgc cgctggcgct cttccagaag 2838061 ataaatagcg tataactcgc cgtcatagcc ttcttgttca gagcgaatag gtccaaatga 2838121 agcaaagccg aatactgaac ccttttcgtc ctgagcaaca aatactccct ttaacgagcg 2838181 acttttccat ttgtcttcaa attccttata gttcaggctg tttaaataat caatcgggat 2838241 aatttcgtgg tatgttgtcc tccagctgtc tacatgcact tttgcaatgt cctttatatc 2838301 ctctaacttc gcttcacgta cagttaccat acggttctgc cctttcctta ctctgatttt 2838361 tggatcgttt tggcttcttt gatttcattt gttaattcat taatgctttg ttttacgttt 2838421 ccttttcctg aaaagttctc aagcatttct tttacatcaa ttcctgagga tgcttttaaa 2838481 ctttcttgca gacttgacat taagttcgtc gcatagctgg ttactttgtt tgctccgctt 2838541 gattcaccgc ttcctcctgt atcgacaacg gtgattttat caatatttga aagaggtgcc 2838601 gctgcttgtt tcgcgtattc cggaagcatt ttgacaatca tatcgaaaat cgccgcctgc 2838661 ccgtactgtt caaaggcggc cgcaattttc tcttttgctt ccgcttctgc aagacctttc 2838721 aggcggataa cctctgcttc tgtctctcct ttcgcttttt ccgcttctgc ttttgctagc 2838781 ccgtcaattc ttactttttc cgcctcagcc tttgccattg cttcaatact gtacttcttg 2838841 gcatcggctt ccgcgagctg tttggctttc tcagctgctg cggactgctc aacagaataa 2838901 cggtctgcat cggctttttt ctttacctct gagtcgtatt gacgttcacg gcgaagaatt 2838961 tctttttctt ctagttctat ttgtttttgg cgttcgataa ttttaacctg catttcctgc 2839021 tctgtgactt gctggcgcgc tcgggcagtc tctaaatcat atgcttggtc ggcattcgct 2839081 tttgccgtat cttgttctct gcggaattca gccattttga gctgattgat tttttcagct 2839141 tcagcgattt ccgtcgcccg ttcaagttct gatttttttg cgtctttatc ggcttctgcc 2839201 cgcttaattc gggtttcttt atcagcctct gctgttgcga tatcagcatc gcgttttact 2839261 tgggcaattc tcggtttccc taatgattca agataaccgt ttttatcacg aacatcttta 2839321 atggtaaacg agacgattac aagtcccatt ttcgcgagat cctgtgaagc gacacgctgc 2839381 acctcttgag agaatttttc tctgttttta tagatttctt ctactgtcat tgagccgaga 2839441 atggaacgaa ggtggccttc taaaacctcc cgcgcttcct gctcacggtc gtcttttgat 2839501 ttccctaaaa attgttcggc cgctgtagcg atttctccta tagaaccgcc gattttaata 2839561 atcgcagttc catcggccat tactggcact ccttgttctg tatagacttc aggtgtcgaa 2839621 acatcgagtt tgcttgataa taggcttagc ggctctgcct gctggaagac gggaaggaca 2839681 aaggttcctc cgccgcggac gattttaata cggttgccgc cttcatcgac atgaacattt 2839741 ttattaccca gatagctccc tgttacaatt aacgcttcat caggccctgc tgtacgatac 2839801 ttcgtaataa acacagctat tagtgcaatt aataaaaaga atacaactcc gatgatcatt 2839861 ataatcggca ttgtcatatc aaattcctcc ttttatgtta aatgggttca tgcggagtaa 2839921 ccgaaagaac tccgttgtta atatctacga ctaacaccgt tgtcccgtaa ctgatctgct 2839981 gattatcaaa actgaccgct gactttgaaa tggtcccgcc tatcccttct atgaccactt 2840041 caccaaaccc gtcaaccggc acagctgtaa tcactttacc gagtcttcct ctgagatcat 2840101 cttctctata tgccaatgat tcttctgcag atgataatgg caccagtaca aagatgtgaa 2840161 gcaataccac cagcatgatc gaaaggatgc aagataaaag cgcaatcagc aagcttgaca 2840221 gaggcaatac aagttcacct atatatccgc ccgctgaaaa acatgtaaaa aatgagagca 2840281 ctaatgtcgg attaagaaac ggaatgcctt ctgacagccc tgaaaataca tctccgaaaa 2840341 acaggaataa cagcgtaagg ctgcccgcaa taataagcgt ataaagatac attgtttgta 2840401 taggtactcc aaataactcc aacttcctca tcctttcttc atcaatgcat tgatgaacgg 2840461 ctgccgttac catttatacg agacacctcg ggaaaagttt caaaatttta agacaaataa 2840521 cccatttgaa gtgctttata aatgataatt gcttatatat atggtaatgt cattttagga 2840581 ggagatatga tgagtatctt taatgaagcc agattagaaa cgtggaacga attgaaagga 2840641 ctttctgacg aaaagctgaa tcaaaagcct tctgctgaag aatggagcat acgggaagtt 2840701 cttgaccatt tgaaaaaaat cgatatgacc gcacaaaaaa tgttgaagga acgtgtaaag 2840761 gacgctccga ttaaagaaat tgaagaaaaa ccgcttgaag tagcacagga cagaaataat 2840821 aaacggaaag ccccgagtca tcttgagcct gcgcatgatt ttatttcagg cagccaaatg 2840881 aaacgtgagc ttgatgtggt aagagagcag ctgactgctg cgattgcctc tctgaaagaa 2840941 gaagattttg aaagagtgct tccgcatcct gtgtttcaag agctgactgt cagacagtgg 2841001 atcgatttta tcggccatca tgaaaaacgg cacctcagcc aaatgaaaga aattaaagaa 2841061 aagatagaaa gggcctgatt taatcagacc ctttctgctt ttcgtttgac ttttcgctga 2841121 taggaatgaa cttctatttc atcacctgtg taaacagcac caggtctctc cacaatacag 2841181 acaatccctc taatgcccag tgcgtggcgg acgaaagccg acgccagctt cggttggtcc 2841241 ggataataag actgaatgac ttctcccggc tggatacacg gatcattttc gccctcacac 2841301 agcagagccg ctccgctcgg aaaaataatc cggcttcctt cttttaatga agtaagatct 2841361 ggcataccgc tgactgccac attcgccccg agccattccg gcaaaattct cggcactccc 2841421 atttttaaag cgatttcgtt gcattcctct attgaaacaa ttgaaatttg tctgcggttg 2841481 aaaatttcag tccctcttga aaacattggt tctctggctc ccgctttttt ggtcaggcca 2841541 aaatgcaagt cgccggggat gccgccataa tcaaaatcaa gcttgtccat ttgctttgtt 2841601 acgaagcttt ttgtatctgc gatatataag ccttccgctt ttgcagtcat acgcttccac 2841661 atcagctggc accttccttc ttatctaaaa tttccaccta tgcttcatta tcccaaaaaa 2841721 tcccgctctg taaaggagcg ggattttgat tataccgttt taggcgtaag gttaaagcag 2841781 cgtttgtaga tccagttgta tgctttttca tttaaatctc tagggtttcc gaaggtttgc 2841841 ggatctttca ttgcttcttt agacaagcgt tcgatcatat caggtgatac tccctgctct 2841901 tctaaagtcg gcacttctaa atcttcgacc agatcataca tccaattgac agatgctttc 2841961 gcagcttctt ctgttgtcat cttgcttgta tcaataccga acgctttcgc aatacgcgca 2842021 aacttctcag gatagccctt ccagttgtat tccatgacag ggcccatcat cgccgctaca 2842081 cattggccgt gagcgactgg gataataccg ccaagcgttt ggctcatcgc atgagcagcg 2842141 cccgctgatt cacttccgta agaaagaccg gcaagcatcg cagcctgcgc cattccgtac 2842201 cttgcttcca gatcctctcc atcagcaaat gccctcttga tgtaatgagc ggcatactca 2842261 atcgccatta aggcaaccgc atccgtgatt ggctgtgcaa atttcattgt atagcactca 2842321 atggcatggg cgagcgcatc aattcccgtc atagctgtta catgcggagg cattgaaaca 2842381 tgaagctcag gatcaatgat tgtcaagtgc gctgcaatca gcggaccgcc cgtgttgaat 2842441 ttgaattctc tttcttcatc tgtgataacc gcccattggg ttacttctga tccggttcca 2842501 gctgtagtgg gaattgtcgt cagcggagga atgcggtttt ccagcggttt tttcccatct 2842561 gccgcttcat aatcaagcac gcttccttcg tgagtcgctt ctactccgat tgcttttgct 2842621 gtatccatgg agcttccgcc tccgactgcc accaaaccat tacagttctc ttttttgtaa 2842681 agctcagatc cttcattcac cagacggaca ggcgggtttg gctcaacttt attaaagagt 2842741 accacttcaa tgcctgcttc tttaagtgat tcgattacgg gatcagcaac accggcttta 2842801 taaatcccag ggtctgtgac aaggagcgct tttgaaacgc ccagtgcagc tacttcctca 2842861 cccgtatgct tgatggctcc gattccatgc ttaatcacag tcggaatttc aaatgtgtgg 2842921 aatttctgca tgctttctac cttcatattt aatgtcatca tcaatctccc cctcttatga 2842981 attaaaccag ttaaccgctg ccggttttgt attgcggtat acatgtttga cttctgtgta 2843041 ttcttcaagg cctatttttc caagctcgcg tccgaacccg gattgcttat atccgcccca 2843101 tggcgcttgt gcaaagtacg gatgaaaatc gttgatccaa acggttccca ttctcaagcg 2843161 ggctgctacc cgttcgcact tttcaatgtc ttttgaccat accgctccag ccaagccata 2843221 gatggtatca ttcgcaagct cgattacctc ttcttcagag ctgaaggttt cgactgtcaa 2843281 tacaggaccg aaaacctctt cctgaacgat tctcatgtca gaattacagt ttgagaaaat 2843341 agtaggttca tagaaaaagc cgttttgaag ctcaggatct tccgggcgtt tgcctcctgt 2843401 ctccagcttc gcgccttcct ctattccgat ctctacatat ttttctacct ttgccctgtg 2843461 ctccgccgaa ataagcggac cgctttctgt ctcagcatga aaaccgtttc cgagttttat 2843521 gcgttttgcc cgtttgacca gctccgccaa aaattgatca tgaatggcat cctcaacaag 2843581 caagcgggaa cctgcagagc atacttggcc ggcgtggaaa aatacagcgt ttaaggcctg 2843641 atcaaccgca acttctaaat ccgcgtcctt gaaaacaata tttgggtttt tcccgccaag 2843701 ttcaagggcg atttttttga cgtttccgct tgccgcccgc atgatttttt tgcctgtttc 2843761 aattccgccc gtaaatgaaa tcaaatcgac gtctttgttt acggcaagct cgtcgcccac 2843821 tgtggctccc ggtccaagaa caagatttgc gacacctttt ggaacaccgg cttcttccat 2843881 cagcttaaag actttgattg tcgtcagcgg cgtaatctca ctcggcttca tgacgattgt 2843941 gtttcctgcg gccagtgcag gggcgatttt ccagctcgct tgaaggagcg gataattcca 2844001 tggagtgatc tggccgcaaa ccccgattgg ctccctaata attttgcttt ctgaatcagg 2844061 aatcggagat gaaatgatct ctccgccatc tttgtctgcc aagccggcgt aatattgaaa 2844121 aacattggcg atatcgtcca tatcggcctt gctttcttcg agtgtttttc ctgtatcaag 2844181 agattcaagc tcagccagct cctcaagatc gcgtctgatt aattccgcaa ttttcagaac 2844241 aatttttccg cgttcaagcc cggatagcga tgaccattct cctttgtcaa atgctctacg 2844301 tgcggctgcg attgctttga tggcgtcctc tcgccctccc tcgcttacag ttgcaatttc 2844361 ttcttgatta aatgggttga taatactgcg gatctgttct ttttcggcac tgatccattc 2844421 tccgtcaatg aataatgttt gactcatata agcctccttg acgtaaataa agtttgttaa 2844481 ataaaaattt aatgttttta acaaccttaa tctaacatat ggtttttaaa ctgtcaaagt 2844541 cccattttga tttttctttt tgacttttcc tcatgtttcg ttaagataaa gaacataaag 2844601 aaataactta acgaatttaa ttttctaaag gaaaagaggg tcagtatgga tgaaaatcca 2844661 gaatttgcag ctatagaaca ggctcgggat cttgttattg actccattgc tgaaacgatg 2844721 gatctttacg gaattacccg cagtgtcggg attttatatg ggacgatgta tatgagggat 2844781 gagatgacgc ttgacgaaat gcgtgaggag ttgcaaatga gcaaaccaag catgagcact 2844841 ggcgtcaaaa agcttcaaga cttaaatgta gtgaaaaaaa catttcaccg gggcatccgc 2844901 aagcatacat ttgtggctga gaaggatttc tttaaatttt tcacaaattt ctttccacct 2844961 aaatgggagc gggaggttca agtgaatgta acagcgatcg aggaagctca agctgattta 2845021 caaaaggttt tatgcaagga agatctcgat gaggatatca aaaatgaagc actgcagtta 2845081 tatgatcagc tggaaagctc taaagcttac tatgactggc tgaaacggct tgctgaatcg 2845141 gtgcagaccg gagaaatttt taaatttata ccggtcgaaa caaagtaaag cagaaaacgc 2845201 ctgggaaact aggcgttttt ttgatgtaac tactacaaat ttgaaaaata cgggaaaaac 2845261 accccattta cttccaaaat atttgatggt aattttatgt aggtaaaatt tgtatttggc 2845321 ctttcagagg aggtgaaaag cgggcaggcc tgtttaattt atcatttttt agggggaatt 2845381 ttgttatgaa acgcaaatta ttatcttctt tggcaattag tgcattaagt ctcgggttac 2845441 tcgtttctgc acctacagct tctttcgcgg ctgaatctac atcaactaaa gctcatactg 2845501 aatccactat gagaacacag tctacagctt cattgttcgc aacaatcact ggcgccagca 2845561 aaacggaatg gtctttctca gatatcgaat tgacttaccg tccaaacacg cttctcagcc 2845621 ttggcgttat ggagtttaca ttgccaagcg gatttactgc aaacacgaaa gacacattga 2845681 acggaaatgc cttgcgtaca acacagatcc tcaataacgg gaaaacagta agagttcctt 2845741 tggcacttga tttgttagga gctggcgaat tcaaattaaa actgaataac aaaacacttc 2845801 ctgccgctgg tacatatact ttccgtgcgg agaataaatc attaagcatc ggaaataaat 2845861 tttacgcaga agccagcatt gacgtggcta agcgcagcac tcctccgact cagccttgcg 2845921 gttgcaacta atgtaaaaga ccggttaacg ccggtctttt ttgcgtttta ccctcccctt 2845981 tttctctaat ccccgttatc ttttttctgg tttaaaattt aaattgacaa acactagaaa 2846041 caggagtaaa ttcttgagtg ttcaatttca tacagtctct tttaccgctt aatcaaacac 2846101 gaacggggga accaacgatt ggctgtttta ttaacagcct tggggtgaat cttactaagt 2846161 aagagggggt actctgaatc cctaatccga cagctaacct cgtaggcgta tacagagagg 2846221 aggtctatta tcggccattc tttgcaatgg tcttttttgt ttcaaaaacg ttaattcact 2846281 aagggagata tgaacattgg gaagaattaa aaataagcaa tttgccgtga tcgggctggg 2846341 ccggtttggc ggcagcattt gtaaagaact tcatagaatg gggcatgagg tccttgcggt 2846401 tgatatcaac gaagaaaagg tcaatgcata tgcttcttac gccactcatg cggtaattgc 2846461 caacgccacc gaagaaaacg aattgctttc attaggaata cgcaattttg aatatgtgat 2846521 tgttgccatc ggagcaaata ttcaagcgag tacgctgacc accctattat taaaggagct 2846581 tgatattcca aatatttggg tgaaggctca aaactattat catcacaagg tgcttgaaaa 2846641 aataggcgct gaccgcatta ttcatcctga aaaagatatg ggggttaaaa tcgcacaaag 2846701 cctttcagac gaaaatgttt tgaattacat tgatctatct gatgaataca gtattgtcga 2846761 gctgctggct acgcgcaagc ttgattcaaa atcgattatt gacctgaatg taagagcaaa 2846821 gtacggctgc acgatcctgg ccattaaaca tcatggagat atctgtcttt cccccgcgcc 2846881 tgaagacatc attcgcgagc aagattgcct ggtgatcatg ggccacaaaa aggatattaa 2846941 acgttttgaa aacgaaggga tgtagacaaa ggtgacactt caaaaggata aagtgatcaa 2847001 atgggttcgg tttacaccgc ctcaagtgct tgccattggt tttttcctta ccattatcat 2847061 cggggctgtc ctattaatgc ttccgatttc cactacgaag ccattgtcat ggatagatgc 2847121 cctttttact gcggcttccg ctacaactgt tacagggctt gctgttgtcg ataccggcac 2847181 tcaatttacg gtattcgggc aaacagtaat tatggggctg attcagattg gcgggcttgg 2847241 atttatgaca tttgcggtct tgatcgtcat gatattagga aaaaaaatcg gcttaaaaga 2847301 acgaatgctc gtccaggaag ccttaaacca gccgacaatc ggcggtgtca ttggccttgt 2847361 caaagtcctg tttctgtttt cgatcagtat tgaattgata gcagcactca ttttatccat 2847421 ccggcttgta cctcaatacg gctggtcatc cggcttgttt gcaagtttgt ttcacgcaat 2847481 atctgctttt aacaatgccg ggttttcgtt gtggcctgat aatttgatga gctacgttgg 2847541 cgatcctaca gtgaacctcg tgattacttt cttatttatt acaggaggga tcggatttac 2847601 ggttctgttt gatgtgatga aaaatcggcg ttttaaaact ttttctttac atacaaagct 2847661 catgcttaca ggaacgctga tgttgaatgc gatcgctatg cttacggtct ttattttaga 2847721 atacagcaac cccggcacgc tcggccacct gcatatagtg gataaactgt gggcctccta 2847781 ttttcaggca gtgacgccga gaaccgcagg gttcaattct ctagattttg gaagcatgag 2847841 agaaggaaca attgtattta ctttattatt gatgtttatc ggagcaggaa gcgcatcaac 2847901 ggcgagcggc attaagctga ctacgttcat cgtgatttta acatctgtta ttgcttactt 2847961 gagaggtaaa aaagaaacgg ttattttccg ccgttccatc aaatatccga ttatcattaa 2848021 agctttagct gtgagcgtca ccagtttgtt catcgtgttt ttagggattt tcgccctgac 2848081 gatcacagaa caagcgccat ttcttcaaat tgtgtttgaa accttttccg cattcggaac 2848141 tgtcggcctt acgatggggc ttactcctga actgacaaca gctggcaagt gtatcatcat 2848201 tgtcatcatg tttatcggaa gaattggtcc tttaacgttc gtgttttcat tcgcaaaaac 2848261 agagcaatca aatatccgtt atcctgatgg cgaagtgttt acagggtgat atcaaaaaaa 2848321 tccggcgtgc agtcgccgga ttttttatga ttcgatatga gattgatttt gtcttttttc 2848381 ctgttccgcg atgatttcgt tatcctccgc gttatcacgg gtcacttttt gcgtaagaat 2848441 cgcaccaact gctacaagta tcataacagc gatgtaataa cctttttcat tgagttccag 2848501 attatcagca ttatagagtc cgatactaaa caaaaatact cccgcaaaaa aagtaaaata 2848561 agctagtact gtaaaggcaa ccgtgtttct gcgtctatat ttctgcacct ttgttccctc 2848621 ccgaaagcat agttaaaaag tgataacttc cgtggaatat tatacctcaa attccccgga 2848681 atggaacaaa gaattaaaaa taccagtaaa aagggcttag gttgcctcct ttatttcaac 2848741 agctgaatca tcaatccagc cgataagttt atcattgatt tggaattggt accatacaga 2848801 ctggcctttc tgttttttag acacaacctt tatgtctttg ccgacgtaag attgggcaga 2848861 ggtaagcctt atggaccgat catcagtaga aggcttggac catacgtctt gaacggcact 2848921 gtctttaata gaggcgttta aatccacaga tttgagggat ggatttacct catcgtactc 2848981 atctaaatcg tatttttcca caatagcgct gattttgtca gcgtagtcag ggtctgtagc 2849041 atatcctgat gtttgcaggg cggttgccgc ttccttataa ttccctgcct caagcaccgg 2849101 tttatacttc tttttattcc acgatgtgcc acggacgaac aattgggcgt gatcatccat 2849161 agattcaaaa aacgtgctgt attttcgaaa cttcgcgcga atggtttttc ttttcccttt 2849221 ttcaacttcg tccgtttcca tcgtgacatg atggccttta taattccctt ttacgccaaa 2849281 aaggttgttg gccttagcag ccagttcact gttcccccag tccgattcga gaatggcctg 2849341 agcaattgtg atgctgggga gaacatggta tttttcatac aaaatttggg catgtccgga 2849401 cagactgtct ataaatactt gctgttcatc gatttcttca gtttctttgg atatttcaat 2849461 cggttttgat aaagttgtcg ctaaaacaaa cagagctagc ggaatcgata caaggaaaaa 2849521 tagtgaaatc aagagtttac gttttttaag ttttttacgg gccatgaaaa ccttccttcg 2849581 aattaaaaga ttacgaatgt aaaagaatct accttttaga attttacttg cacttctaat 2849641 atttttcaat tctttaggga taaagttggg aaaagattgc aaaataaaaa ccttttcgct 2849701 caatgaaaag gtttttacca tgtttctatt tttgtaaatt tctgagtgca ttccgatatt 2849761 ccgtatcatt tattacttta tatgatttga cagttgcctt cgacaaacct tgtgctgaga 2849821 cggccggttt ttccggagct gttttcgctt tatcatgtgg tttatgtgcc agcttgtgcc 2849881 ccattccagt ggcattcata caaaatgaca ggcagacgag cagcacgcta aggataaaag 2849941 aaatgaagaa gagatcatga taagcagtca tcatagaatc ctgtaccgaa ccgctttgtc 2850001 tggcagcatc ttttttcgtg aaaaagccga tgagaatggg aactcccata tagacaaaca 2850061 atcttaaaaa ctgaacagct gtcattctct tgaccaaatc aggcagcggg cctcccatgg 2850121 cagctcccat cagccctgcg gcgactgtca ggcctgttcc cgctgcaagc atgataaaca 2850181 gtgccgcgaa catataaaga gatgatcgat cctgtatatg cagccattga aaattcacaa 2850241 aaacgagaat gagtccgccg ataataccga gcatccctgg tccgacttta tcgtataaca 2850301 gagcgctcaa aatggccgcg atcgccactc cgattaaaag agtcaagctt aaaagaatga 2850361 gatgctcctg agaaatatca tacatttgac ggagcaagcc ttgaaaagca gaaaggctga 2850421 cagctaccgt tatcgtccct gcagctatga tcaataagcc gagcaccggt tttggcagca 2850481 gcatcagttt aatagatatg aaggggtttt tcactttata ttccacaatc aatagaccaa 2850541 tgagcaaaca taacgtcacc ccgaaaccaa tccatacata acccgatgac agcccccatt 2850601 tttgcagaaa aatgaatgaa accgctgagg ctgcggcaag gaagacagat aaaagaattc 2850661 ccgcacgatc aagcggctgt tcttgatccg ccgctccgtg atgctcatca tgaagaaaga 2850721 aatagctcac cgcgacaccg atcagggaca aggtgccaaa gatgaaaaac agccatctcc 2850781 aatgcccgca gcttgttgca atggttccca ggattgtacc gatgataaca gaaccataga 2850841 atcccccgat cagcacaagc agtgcatagt tcctgcgttc aatcgggaat gacagtacaa 2850901 gcattggaat cataatcatc agcatgacgc ctgttgccgc cccttgtaaa aagcgccctg 2850961 ccgccatcaa tgcaatatcg cctgaacatg cgatgagcag tgagcctagt ataaagacag 2851021 gtaatgaagc cagatagacg ggacgagcac cgaatttttt cctcagcagc ggtcctgccg 2851081 gaactaacaa ggcaaaggcc atattgccga tcaatatcgg atttactgat gtaaagacac 2851141 ttgttccaac cgttttctga acaaggcctt gaactgacga caatgccgtg ttagacatca 2851201 atcccggccc gaccgctaag acggcgagca aagaaatcac ccaatagtgt tttgtcttca 2851261 tgttgtcatc ccttcctata tgaatacatg cgaaacacat cattttttga aaacaaaaga 2851321 agctaataga ttttgcatac cattagcttt cattctaata ttctcccttt caggggaaat 2851381 gatattattt tattataatt atgtgaatga atgagcatat aatcaaatat tatttcaaat 2851441 cgattgtgtt ttgtcaatgg agtaaatttc aagcacaaca tagaaagctt gaaagctttt 2851501 ccccgatatt gtgtctagaa ctgcacttat gaatccctgc tcgttccctc aagcgaatta 2851561 aagcaggccg ttttaatcct ttcaatccac tattccaact aataaactca aataagttgg 2851621 tgataagaca acattttacc cccacatttt tttgtgttca ctgggcgttt gccgcctcta 2851681 aattgtatat gggtaaatac catgaattaa cctatgaaat accaatgtaa gggaggcaaa 2851741 aacgaatgga actgtatgag tgtatccaag acatttttgg cggcttgaaa aatccatcgg 2851801 ttaaagattt agcaacgtct ttaaaacaaa ttccaaacgc agcaaaattg agtcaaccgt 2851861 atattaagga accagaccag tacgcttacg gccgaaatgc catctatcga aataatgaat 2851921 tggaaattat cgtgattaac attccgccaa acaaggagac aacagtacac gatcatggtc 2851981 aatccattgg ttgtgcaatg gtgttagaag gaaagcttct taattctatt tatcgttcaa 2852041 ccggcgaaca cgcagaactc tccaattcat actttgtcca cgaaggagaa tgccttattt 2852101 caaccaaagg tttaattcac aaaatgtcca atccaacatc tgaacgaatg gtgtctcttc 2852161 atgtctactc ccctcctttg gaagacatga cggtctttga ggaacaaaag gaggtattgg 2852221 aaaattcatg attgacagat aaactgctca ctttgacttc actcaactgg aggattcaga 2852281 gaatgaaacc ttttcctcaa aacaaaaaaa cccttatcga ataagggttt aaaggtatgg 2852341 agccaagggg gctcgaaccc ctgacctcta cgctgccagc gtagcgctct cccagctgag 2852401 ctatggcccc gtatgtaacg tcatgtttat tatagatgat tttattttga aaaacaagct 2852461 gtttcctctt gaattgacag aaaaaataag gctcggaaaa gagccttatt tttcgactta 2852521 catcatgatc aaaagtaaaa tcacaccgag aataattcga tagattgcaa atgggacaag 2852581 tttgattttg ttaatcagcc ttaagaagaa acggacgaca aacagtgcga ccacaaaggc 2852641 acagataaag ccgacgatga aaaacggcat cagatccgaa cttaagctgt cccaatgctt 2852701 cacgaggctt agaaagctgg ctcccatcat gatcggcatc gccataataa acgtaaagtc 2852761 ggctgcagct cggtggttta atccgagaat aacaccgccg gaaatggttg aacccgaacg 2852821 cgagaaacca ggccaaaggg aaagacattg gaataagccg acggctatcg cctgtttata 2852881 ggaaatgcgg tcgagtgtgt ctgtcgctgt tttccgttta ttgacccagt cagcaaaaag 2852941 catgaggatt gccccggcaa ttaaaccgat ggccacagtt ttaacggaaa ataaatattc 2853001 atcaatgtaa tcttcaaaca aaaagccgag aacagctgca ggcacgagtc cgacggcaat 2853061 ttgggcaatg cttaatttat gtccctgctc ctggtcgctt gtaatatttt ttttcaagcc 2853121 cagtaaattt aaaattcggt ctttaaacac gatagctact gctaaaatgg agcctagctg 2853181 aataaccacc ttgaatgagt tagcagcttc ttctgacatc agattacttg attttagcca 2853241 gatgtcgtct actatgatca tatgtcctgt cgaagaaacc ggcgcgtact ctgttaatcc 2853301 ttctacgatt cctaaaatgg cggctacaaa caattcccat agagtcatga ttttgattct 2853361 ccccattaga catttatttt tttacataac gggagcttcc cataaatgga aagcccgtct 2853421 tatataacta taaacgaaaa tcacacttta tgccccggcg tattttcatt tttttcttca 2853481 tcgtataaat gtgactgcat tttaaaccag tcaaataaat gtgtcgtaat gactttggca 2853541 accgcatagc cgggaatcgc aagaatgatt ccaacaacgc caaacagctt gccggctgtt 2853601 aacagcagaa aaataatcgt aatcggatgg atgtgaaggt tttttcccat aatttgcgga 2853661 gagatcagct tcccttcaat cagctgaaca atcgtccaaa cgatcaccag cttaagcagc 2853721 atgagcggcg atgtcactat ggcaatgata atcgcaggcg taatggcaat cgttggccct 2853781 aaatatggaa cgatgcttgt gcaagccgca atgactgcaa gcaatgaagc ataatccagc 2853841 ccgataatca aataaccgat aaacagcaaa aacccgatac agaagctgac aatgatctgg 2853901 cctctgatat aagagcttaa ccgatgattc atttcgctta agactgtata tgtctgttct 2853961 ttcaatcgag tcggcacaaa cttcagtatg tagaccggta attttcttcc gtcttttagc 2854021 aaataaaata gaataaacgg aaccgtgacg atcgaaatga taatctcagt cagtgcgccg 2854081 ataaaattcc caacaccggt aaaggtgctg ttcacgatcg tcgctgcctg atccgaaacc 2854141 tttgtagcaa gatcagatat attaatgttc atcgtttgct gggcctgatt gacgaagttg 2854201 ctgccaatca gctgtttcgt ctgattttct acgacgtcca catatctcgg gatattgtca 2854261 atcaaactca taatttgttc ttttaagaag ggaatgatcg acacgatcgt gatcgtgatc 2854321 agcccgataa ccaataggta tagcagcaat atagaataga ttcttcttat tcttcttctc 2854381 tccagaaaat cgacgactgg gtttaacaga taaaaaacaa tgcctgtcaa aataatcgga 2854441 agtgatatcg ttttgagcag aacaataatc ggggtgaaaa taaatgatgt ttttgtaaat 2854501 actagaatat ttaaaccaat cagcagcagc acaagcaaaa ataaaacaaa cttattatcc 2854561 aagaagaatc gcttgaatct gccgctccat gtttgcaacg tctccactat cgttcctccg 2854621 tcatacatag tttaattaaa ttgtacacta tcgtccctat aatgaaaaat aaaaaccgtt 2854681 aattgctgga aaagctttct cggttttaac attctattta tatctatcat gtgattttgt 2854741 tctttttaag ctataattta gctatatcat gcaaaaggag cgatacgagt gatacgtttt 2854801 gcaataatag gaaccaactg gattacagac cgctttcttg agtcagcagc ggatatcgaa 2854861 gattttcagc tgactgctgt ttattcaaga tcggctgaac gcgctggcga gtttgctgct 2854921 aaacacaacg ctgcgcatgc cttctcagac cttcaggaaa tggcggcgag cgattgcttt 2854981 gatgccgtat acatagcgag cccgaacgct cttcacaagg aacaagccgt tctctttatg 2855041 aaccatggca agcatgtgct ttgtgagaag ccgtttgctt cgaatacaaa agaaacagaa 2855101 gagatgatct cagcggctaa ggcaaacggc gttgttctca tggaagcaat gaagaccact 2855161 ttcctgccga atttcaaaga actgaaaaaa cacctgcata aaatcggcac tgtccgcaga 2855221 tttaccgcaa gctactgcca gtattcctca cgatatgacg cgttcagaag cggaactgtt 2855281 ttgaatgcgt ttcagcctga gctttccaat gggtcattaa tggatattgg cgtctattgt 2855341 atttatccgg ctgttgtgtt gtttggcgcg ccgaaggatg taaaagcaaa cggatatgct 2855401 ttatcctccg gagtggacgg agaaggaact gtcattctgt cttacgacgg gttcgaagct 2855461 gttctgatgc attccaaaat ctctacttcc tatgccccgg ctgaaatcca gggtgaagac 2855521 gggacgattg taatcgatac gattcaccgg cctgaacgtg ttgaaatccg ctaccgggac 2855581 ggccgccttg aaaacatcgc gatccctgat cctaaaccgg cgatgttcta tgaagcagaa 2855641 gaatttgtca cgcttataaa agagaataag ctggaatctg aagaaaatac atttgaacgg 2855701 tctttgacca ccgcaaaaat tatggaagaa gcaagaaagc aaatggggat tgtataccct 2855761 gctgatcaag cttaaaaaaa tccgcccgcg tgcaaatgcc gcggcggatt ttttattaga 2855821 caatcggaga agatgccttc ctttttaaaa gcacctgttg ctcatattct ttgatgtcat 2855881 aaagccatgc ctcttttacc ggaacgccca tttgctcaca gtaggaatcc cagatggctc 2855941 cgaaaggata tgttttgaat tcctccatca gggccagcct ttctgtatag cggccctctt 2856001 cctgcaattg ttttaaatat ccgttcggga gaagcagggc atacaataaa gctttgatca 2856061 tatttctcgt tccgatggtc caggcggcta cacggttaat gctggcatcg aaaaaatcca 2856121 gaccgatggc taccttctca agagcatgat ttcgtacaat ttcaagagcg atttctctca 2856181 attcatcatc caaaaccact acatggtcgc tatcccaacg aacaggccgc gatacgtgca 2856241 aggcaagctt gtctgtgtaa agcagcatgg acgagatctt gtttgatacc gtctcagtcg 2856301 gatggaaatg gcctgtatca agtaaacaaa gcttatgatt cgtcaaagca taagctaaat 2856361 aaaattcatg agatccgaca acatatgatt cggagccaag cccgaacagc ttgctctcga 2856421 ttgaatcaag attatgttgt tcactgatct cctctgagaa gatccgatcc agtgattctt 2856481 ttagtctttt acgcggtgtc agcctatcac tcgggatatc cttatagccg tcgggaatcc 2856541 aaatattcgt caagcaaggt gttcctaatt ctttcccgaa gtattccccg atacggcggc 2856601 aagcgatgca atgcctgatc caaaattctc tgatgtccgg atcagggtgt gaaagggtga 2856661 gtccgtcagc cgctttctca tgcgaaaaca aggttggatt aaaatctaaa ccgagaccaa 2856721 ggttttttgc ccatttcacc cagttttcaa aatgctgcgg cttcaattcg tcacgttcta 2856781 ccgcttccct gtttgtttct gcgtatatcg catgcaggtt tacgcggtgc tttccaggaa 2856841 tgagagaaag agccttctcc aaatctcttc ttaattcttc aggagtttgc gcttttccgg 2856901 gataattgcc ggtcacgtca attccgcctg aaagctcgcc cttatttact tcaaagcctt 2856961 caatgtcgtc accctgccag cagtggatcg aaatgggcac ttgctctaat tgccgaagcg 2857021 cctcttcaac atcaattccc catttttcat atgcctgttt tgcactgtca taattggctt 2857081 ttatggtcat acggctctct ccctttatca gtttttcaat ccaaataaaa aacttccttt 2857141 agatctatcg caacaggact gaaatccgaa tttgttttca ttaatggcgc catcgatttc 2857201 caccatcttt ggcaaacttc cgtgtccgcc atctttctcc atttctcttc atcctctatt 2857261 tctaaatatg caaaaagcct gcctgtttcc tcgtctagaa aaatggaata atggtgtgct 2857321 ccatgagctt tgagtgcttc tgccatctca ggccaaatgt catcatgccg ctgtttgtat 2857381 tcttcgtact tgtcttgatg gacaaacatg atactggctt ttcttttcaa accttttcac 2857441 ctcttcatca tttagatagc gctttcaaaa cagtttgctg aaatgactga atgatcgtgc 2857501 ttctatcaat gtctttaggt gtaaacactt tgatcggaaa ggaatttctg acgacttgcc 2857561 gggcttcttt tatgtctttg acttctttgg cagcaatcat ttgcatcaaa agatttccgg 2857621 tggcagttgc ctctatcggc cctgcatata ccgcttttcc actcatgtct gccgttaatt 2857681 gatttaagaa atcattccgg gctccgccgc cgatgatatg aaattgctcg atcggttttt 2857741 ctgtgattgt ttcgagctct ttgatggcta tcgcatagat gatggctaaa ttgctgtaga 2857801 tgcagcaggc aagttcgcct gcagtacggg gaatcttttg gcgggtttgt ctgcaataat 2857861 gttgtatttc ctttatcatg ttttctggat tcaggaaacg tttatcattt aagtttataa 2857921 attgctggaa tggttctgtt tttttggctt cttctgcaag ctgctgaaaa gaataatctg 2857981 cttgtagctg ctgtttgact tcttgtatca cccacatgcc gataatgttt ttgagaaagc 2858041 gaatggtgtt gtttgcgccg cgttcatttg tatagttgtt ttctaaagca agatcagtta 2858101 ttatcggtgt tttgttttca accccgatta acgaccatgt tccgctgctg atatacgccc 2858161 agccatcatt tacgcctggc gccgcaatga cggccgaggc cgtatcatgt gttgcgactg 2858221 tcatcacctt gcacgccggg agatcataat ccgggaacca ctcatttctt agcttcccga 2858281 gttcacaccc cggttcagtg agcggcgcaa attgctgttc cagaacagac acggcttcaa 2858341 gcaattcagg atcaagattt cccgttgaga cgtttaaaag ctgtgttgtg gacacgtttg 2858401 tgatttccgt tacagctttt ccggttaaac aatagcctaa ataatcagga atcatcataa 2858461 ttttgtctgt ctttttcagc agctcacggt cttcttcaaa caattgatag atcgtgttga 2858521 aaggctgaaa ttgtattcct gttttttgat aaattgcggc ttttgagagg gtatgttcca 2858581 gtttgtctat tgtgtgatct gttcttctat cacggtagga gattgcttcc cgcaaccgat 2858641 cgcctttttc gtccagtaag acataatcga ctgcccatgt atcaatgcct acggtgcagt 2858701 gttcataccc aagcgtcttt actttttgca gtccttgcag gatttgtttt agcaaatgat 2858761 caatatccca taagcaatgc ccgtctcttt gactgaaacc gttagcgaac ctgtgaatct 2858821 cttgtatgtc aagcttccct tcattcagtt cacctaccat gattctcccg cttgatgcgc 2858881 ctacatcaat ggcagtataa atcatccttt caccctctct tcgaaagagg aacagctgtc 2858941 accttcacct ttttgtcctc aagagctttt accgatgccg gatcaagtcc agaatccgta 2859001 ataaggcggc tgacatcttg cagcgaggcg atatgtgaaa actcgcggtt cccccatttg 2859061 cttgaatcgg ccatcaaaat ggtctggtcc gacctttcga tcatccgttt tttgagcagc 2859121 gcctgccact catttgaatc actcatcccg ttgtgtacgt caaatccctt acatgacaga 2859181 aaggttttat tgacatgata ggtctcaagt gaacgctctg ctaacgggcc ggcaaatgat 2859241 aatgattttt ccagcaaaat gccgcctgtt gaaatgactg atatgttttc tttattgctg 2859301 agttcaatag ctgctttcat tgagtttgta atcacggtga gctcaatgtc agggagtatt 2859361 tttgccatgt accaagcggt tgtgcttgca tcgagaatga ttcggtctcc gctttttaca 2859421 tatttggccg cttcgtgagc gatggctttt ttttcgatga cattcgtgat ttcccgttca 2859481 gaaaaatgaa tttctgattc cttctgctga atactgaccg ctcctccgtg gctccggctc 2859541 agtttatgtt ctttttcaag cttttcaaga tcacgccgaa tggtttcctc tgtgactgaa 2859601 aaaatgtcac ttaattcgga aacgcggatg cttgaacgca tatttactat ttccactatt 2859661 ttttgctgcc gttctgctac tagcatcggt aacgcccttc ctcatatcgt agtccgtctt 2859721 atatttttat catagcatat atctaacgcg taaaagcagc agggacgccg ccgtctaccg 2859781 tgatcatgca gcccgttgtt ttttcggctt tggaagaagc gaagaatgca atggcttcgg 2859841 caatatcctc cgggtaaata ttgacgagca atgctgtccg tttccggtaa tgttcctcca 2859901 gctgatccgg ttcaatcccg tacgccgcgg ctcgttcctc acgccagctt gaaccccaga 2859961 ttgccgatcc ttgaagaact gcatcaggca aaacggagtt gaccctaatg ccgaattctc 2860021 cgccttctgc tgcgatgcat cttgctaaat gggtttcaag cgccttaaca gagctgtagg 2860081 cagaggcgtt ttttcccgca taaactgaat ttttcgatcc gacaaatacc atgcttccgc 2860141 ctctattttg atgtttcatc tgtttaaacg cttcacgggc tacaaggaaa tagcctgttc 2860201 ctaaaacatt catattaaga ttccattctt ttagacttgt ttcgtcaaat gggcttgatg 2860261 tggccagccc ggcattattg acgacgatat caatgccgcc gtaagcaagc gccgctcgtt 2860321 caaaagctga ctgtacgtct tcctcctttg tcacatccat tttgacagcc attgcccgtc 2860381 cttttccgta tgcatcgttt atttccccgg caattttctg tgcgccttct atattcagat 2860441 cagctacgat cacgtgccct ccctcagctg caaatcggcg gcatgccgca ctgccgattc 2860501 cgccggctcc tccagttatc agcgctactt ttcgggaaaa ttctgcttcc ggcggggcca 2860561 gcgtgagttt atatagttcg agcggccaat attcgacatg gtaggactca ttttcatgta 2860621 aagaaacaaa ttgccccaga gcggttgctc ctttcattac ggcgatggcc ctccgatata 2860681 aagccccgct tactttagac atcgcataac tttttcctgt attcaccatt ccgattccag 2860741 gaatcaatat cacccgcggg gcggattcaa agatttgatc cccatcctgc tgattgcgtg 2860801 taaagtaagc ctgatactct gatgtaaagg tctcgactcc tgacttgatc agatctgcaa 2860861 gcttgtgcac atcttgagtt tccggattcc aatcaatgta cagcggaacc cgttttgtgt 2860921 gaacaaggtg atccgggcat gccgcaccga tttgcgaaag tgctggcgct tggacactgt 2860981 ttacaaattc caagacatcg tcatgatcat cataggaaag gatcattttc ttttcttcac 2861041 ttactgctcc tctgatcaca ggcatgatgc ctgccaagat ttgttttctt ttatcctccg 2861101 gcagcggctg ataccttttg cctccgaata cctcatgctg attgatacga tcgttaatat 2861161 actgctcggc ttcttgaatg atggatatcg ttttttgata acatgtttca gacgtctctc 2861221 cccaagtgac taagccgtgt ttctccatta atacaagctc ggcgtggggg ttgtttgcta 2861281 cgccttcagc gatcatttta gacaaagtaa atccaggacg gacgtatggc acccatacaa 2861341 accgatttcc gtaaatgtct tcagcgattt gttttccatt atccgcacag catatgctga 2861401 taatcgcatc tggatgggta tggtcaacat gtttgtatgg cagaaaagcg tgtaatagcg 2861461 tttcaattga agggcgggga tgtttgctgt ctatcataca atgagacagg tagtctacca 2861521 tttcttcatc gggcatttgg tcccttttaa tcagcgggcg gatatcatct aatttcaaac 2861581 cggaaaagtt atgcgctttc attgttgcca aatccgatcc gcttcctttt acccacatga 2861641 cttctatttc acggcctcta aaatcctttt ccgttgtttt catagatgta ttccccccgc 2861701 cccagttgca gacagtgcgg tctgacccga tcagattgga cctgtacacc aattcctcta 2861761 cacctttagg tagctgtgca gctcgctctg aatcccatat atgtttcacc atatttgata 2861821 ttcctccata cccttttatt tgtatccgtt ttcattatat atgatttctg tttgtttttg 2861881 aatcgttttt gtttattttt gctttttaac aaaaaaagaa agcagcagat atgccgcttt 2861941 ctcgtttcat tatgattcta ttttaaattt cttcgtaatg tcctgaagtt cttccgccat 2862001 gtttgccaac gtttccgctg aagagctgat ttcttccatg gacgcaagct gttcttccgc 2862061 cgaagctgcg atatcctgaa tgcctgctga gctttctttc gccactgcag aaatatcttc 2862121 aacagcactt gacacttcct gtgatccggc tgacagttgt tcaaccgtcg cgttcaagtt 2862181 ttgcaattcg ccggaaattt gggttgtcat ctcatagatt tgtttaaagc tttccgctgt 2862241 ttgatccgta atctgcaagc cttctttcac ttcatgattc acggattgga acattgaaag 2862301 tgaggtgctg atttccctga caatctcttg aattaatcct tcaatttcct tggcggagtc 2862361 tgctgattgt acagcaagtt ttctaacctc ttccgcaact actgagaaac ctcttccgta 2862421 ttctcccgct cttgccgcct caatcgcagc atttaatgca agcaggttgg tttgatcagc 2862481 aatgccgtta atcacattca agatgcttgt gatgtcttgc gattttgttt caaggccctt 2862541 cacaaccgct tccgcttttt gaacggattg gtcaattgtt ttcatctggc cgactgtatg 2862601 ctccaccagc ttttctccgc tgcccgctgc ctcagaggac tgaatcgatg atttcgtaat 2862661 ggttgaagag gcttgagcca cttttgaaat cccctcgttc atttgagaaa gatgatttga 2862721 gcttgtttcc agtttctcgc tttgtgcctc gttgccatct gagaactgtt cgatggcaag 2862781 tgtaatatgt tcagttgcct tgcttgtttg ggctgcgctt gctgtcagct cctcagaaga 2862841 tgaagcgacg ttttctacag acgtttgaat aacgcctatt acagaacgca atgatgcaga 2862901 catttcatta aagctttcgc caagctggcc aaactcgttt ttcgagtgaa tgtcaatgac 2862961 ttctgtgaga tctccgctgc tgatttttgc agacgttgag acaagttttc ttaacggctt 2863021 ggtgatggca cggataatat agagtatgag tatgccgccg attactattg acacgcatag 2863081 aatgataacc gcagtgttca gcaccgggct tgaagcatct tgcaattcac tgacaaaata 2863141 tgtgcccgcg attttccagc cagtcagttt atttgtcgta aaggccattt tcttttcttt 2863201 gccttcgaat gtatattcaa atgagccttc ttttttggaa tatacttggt ttgtccaatc 2863261 gccggaaccg gttgtccccg gcttaatggt cggatgggcg atatattttt tgttgcctgt 2863321 cgtaataaat gcaaagcctt cttttccgat tttgattctt tttgatgcag taagcacttc 2863381 atccaggttt aaatctagcg ctataacccc tgaaccgtct tttaattgtt ttgaaattgt 2863441 gacaacgata tctcctgtcg cttcatcggt atacggttct gagaaaacag cttgtccttt 2863501 ttccgcaacc gcctgtttgt accagtcacg tcctgtcgga tcgaaacctt tcggaacacc 2863561 gctatccgga tatttataaa gcttcttatc ttctgaggca gcatagattg cgcctacatc 2863621 gtcgttaagt gtcgtgtact gcttaaattt ctctttcagt aatgttttgt ttttgcctaa 2863681 caatatgtct ttatcgactg tctcactata ataatctatt gcttttactt tatcttctaa 2863741 tttattttgc agcgtactgt ttagttcttc aacatttccc ttcgcactgc ttatgagctc 2863801 tctgtctaac gcgttccaag ctgattgata actgaaatat gctaaaaccc caaccggcaa 2863861 aataagcact gccagaaacg cagcgattag cggtttgctg atcgatggct gtttgatcca 2863921 ttgtatgaat tttcccattc tcgttgactc ctcctttaag ataaatctaa tatcgtcaaa 2863981 ctaggataaa aggtttaata aaaaaactaa aaaaaacacc caagcgcaac aagcttgggt 2864041 gttaaggctt attattcaat tttaaatcgt ttggtcatat cccgaagctc ttccgccata 2864101 gaggaaaggg tctctgcaga cgagctgatt tcttccatgg aagctagctg ctcttcagct 2864161 gacgccgcga tatcttgtat atgcgctgag ctttcttttg aaatcgatgc aatgtgctca 2864221 gacgctcccg aaacttcttc ggagctggca gaaagctgct gaaccgtcgc actcatattt 2864281 tgcagttcgc cggcgatttg gttcgtcatt tcagaaatgc gtttgaagct catttctgtt 2864341 ttatctgtga tgtcaagtcc tgtctgcacc tcttgattga cagattggaa catgccgagt 2864401 gatgtattga tttccttcac aatttcgatg attaatcctt caatctcttt tgctgaatct 2864461 gctgactgta ctgccagttt tcttacttct tccgctacaa cggagaagcc gcggccgtac 2864521 tcgcctgcgc gcgctgcttc aattgctgcg tttaaggcaa gcaggttcgt ctggtctgcg 2864581 atgccgttga tcacacgcaa aatgtttgta atatctttcg atttcgtttc caatccgcgt 2864641 acgacttgct ccgcttcttt aacggacttg tcaatgacat tcatttggcc gacggtttga 2864701 tgaacaagct tgccgccttc acttgcaatt tctgtcgatt gaacagatga atcagtgatc 2864761 acttcagaag cttgagccat attcgtcaac ccgtcattca tttgataaat gtgctctgct 2864821 gccgtttcaa tgttttcgtt ttgtttttca ttgccgttag aaaattgttc aatcgccaat 2864881 gtaatgtgct ctgttgcctt gctcgtttgc gcagctgatg cagtcagctc ctcagaggaa 2864941 gcggcaacat tgtctaccga atcctggatg gcgtgtatga gagaacgaag tgacgacgcc 2865001 atattgttaa agcttttgcc gagctcgccc aattcatctt ttgaacggat atcaatggtt 2865061 tccgtcaaat ctccctcgct gatccgctta gaggaaccga caagctgttt cagcggtgtt 2865121 gtaatcgacc gaatgatcaa tgtcatgacg ataatcccta tgataatagc tgcggccaag 2865181 acaattaaag caaggtgaag gacaggctgg gctgcctcat ggatttcatc caaatacatg 2865241 gtgccgccga tcttccatcc cgtcaacttg tttgtgtcaa aggccatttt tttcttatcg 2865301 ccatccatgg tgtattgaaa atcgccttta tcagcactca acatcttatc gagccagtcg 2865361 ccttttaatt cagttcctga ttgttcatta gggtgtgcga caactttttt gtccttcgtc 2865421 atgataaatg cgtagccttg tgtgccgatg ttgacttttt tggttgtttt cagcagattt 2865481 tcaatcgtca tgttgattgc gataacgcct gaaccatctt ttgtctgctg ggcgattgtc 2865541 acaaccatcg tatttgtcga cgcggtttta taagggtctg tgatcacgac tttcccttta 2865601 tttgcaaccg cttttttgta ccagtcgcgt tcaaccggat tatagccgct tggcatcgga 2865661 agatccggat agcgggtaaa gtgccctttt gtgtcacttg tataaatgga ttctacatcc 2865721 ttgttaatgc tgatatattg tgagaatttc tctgcaatgc ttgcattgct ttttgcattg 2865781 tatttctctt ttgtcagcca ttcgctgaaa taatcagcac tgttttcttt ttcgccgatg 2865841 ctggtgttaa tgatttcgtt taattgctgt acattttcca atgcgctccc catcatctgt 2865901 ctgtcgagtg agctgctagc cgattgatac gcaaagatcg ccaatatgac aaccggtatg 2865961 atgaggatcg acagaaagga aacgagaagc ttccgtgtaa ttgatctttg ttttatgagt 2866021 tggagtattt ttttcatcat tcatttctcc ttttttatgc tacccttcat atcggctgga 2866081 aatgggtaaa tatatacagc aaaaaagaag aaatttaaca aaagtaacta atttcccata 2866141 aataaatagt attttagacc tattatttgt ctactttaaa ttgttttgtc agatcacgga 2866201 gttcttcaga cattctttca agcgtcagtg cagatgaact aatctcctcc atggatgcca 2866261 gctgttcctc agctgaagcg gcgatatctt ggatgccatc cgagctttcc ttagaaatgg 2866321 cagtgatatc atttgaagct gcggaaattt cttgagctcc cgctgacagc tcctcaaccg 2866381 tcgcattcat gttttgcagc tcggaagcaa tttgattggt catttgcgat atatgtttga 2866441 agctctgttt agtttcatcc gtcatgacaa gccctgtttc aacttctttg tttacggact 2866501 gaagcacgtt cagtgatgtg tgaatttctt ttactatttc actgatcagc gattcaattt 2866561 cttttgctga gtcagccgac tgtaccgcga gctttctcac ttcctcagcg acgactgaga 2866621 agccccggcc gtattcaccc gctctggcag cttcaatggc ggcatttaaa gccaaaagat 2866681 tggtttgatc cgcaatgccg ttgatgacac gcaaaatatt cgtgatatcc tttgatttga 2866741 tctccagccc tttcaccact tgttccgctg cttttacgga atggtcaatt gtgttcattt 2866801 ggccggctgt tttctggacg agtgtctccc ctttgcttga cacttcggtt gaatctgcgg 2866861 atgtttctgt aatcactgct gcagcccgcg ccagctctgc caatccgtca ttcatttcat 2866921 taatttgttc ggttgtcgtt tctattttct cgctttggct ttcactgccg tttgaaaatt 2866981 gctcgatagc catcgtaatg tgctcagtgg ctctgcttgt ctggtctgcc gatgcagtca 2867041 gctcttcaga cgaggaggca acgtgttcta ctgagtcttt gatcccgtga atgagcgagc 2867101 gaagcgagtg tgccatatga ttgaagctct cactcagaac gccgagttca tcttttgaat 2867161 tgatttcaat cgtttcggtt agatcgcctt cactaatttt ttcagcggat gcgacaatgc 2867221 gtctcaatgg ctttgtgatg gatcgaatca caaaataaat cgccgtcatt ccagctccga 2867281 tggcaatcgc cagaacgatt gaagccatga tcagaaccct gcttgcagca tcgtgaatct 2867341 cgtttgcata catcgtgccg ctgattttcc agcctgttgt ttggcttgtt gcaaatgcca 2867401 tttttttctt tttgcctttg tacgtatatt caaagtcccc gcttttatcc ttgtagagct 2867461 tatcaaccca gtcccctttt agctctgttc ccgctttttc tccggagtag gcgatgactt 2867521 tcttgttttg gctcaaaata aaagcatagc cttcttttcc gatattgatt cctttcgcgg 2867581 tagtgactaa gtcatcaatt ttcatatcaa tggcgacaac gcctgaccca tccaccgttt 2867641 gacgggcgat ggtgacgacc atttttcctg atgaaatcga ttcataaggc tcagtgacaa 2867701 ttgttttgcc tttattggcc attgcttctt tgtaccaatc tcgttccaaa gcattaaagt 2867761 cgcttggcat gtcagcgtac ggataacgtg tgaagtcccc gtctttgccg cttgaaaata 2867821 ccgcagcgac attatcattc atttggataa attgtttaaa ttcctgtttc agctctgttt 2867881 tctttttatc ctgaaatttt tctgctgtag cccaatcgct gaaatatgcg aggctttttt 2867941 cagtagtgct gattttatca tcaatgatgt gatctaatat ctgaacattt tcctttgcgc 2868001 tttgcgtcat ctgtacatca agtgaggcaa ctgctgattg ataagcgcta accgaaaggg 2868061 cggttatcgg aacaattaag atcagcagga aagaaataat aagtctcctt gcaattgatg 2868121 atctgcgaat agtggtgagt gtttttttca tttccttttg aaccttcttt caataattta 2868181 caaattatat cggcggatct tcctttaaat tacattgaaa atggaggaaa aaatgaaaaa 2868241 tagttctaaa ttcacctgtt aaactaggac tttattattg tttaccatat aaaaaaacag 2868301 cgctttgata gcgctgtttt tcggttttta ctcgatttta aattgtttcg tcagatcgcg 2868361 aagctcttct gccatctgcg caagagtcgt cgctgaggaa ctgatttctt ccatggaagc 2868421 aagctgttct tcagctgatg cggcaatgtc ctggatgctt gccgagcttt ctttcgacac 2868481 gtctgcaatg ccgctgactg ctgctgaaac atgctgtgaa cggtctgaca gctgctcgac 2868541 ggtggaattc atcgtctgca gcttgcccgc gatttcgttt gtcatgctga aaatgctctg 2868601 gaagctttct tttgtattgt ctgtgacaac aagtccggac tgtacttcct gattgacctc 2868661 tttaaacatg tgaagagagg tgtcgatttc tgcgacgatt tcttggatca gcttttcgat 2868721 ttctttcgct gaatcggctg attggacagc cagcttgcgc acctcctccg ctacgacaga 2868781 gaagccgcgt cctgactctc cggcacgcgc cgcttcaatg gctgcattta gtgcaagcag 2868841 atttgtttgg tcagcgattc cgttgatgac tctcaaaatg cttgtgatgt cttttgattt 2868901 tccttctaag cctttgacaa cagcttcagc ctgctgaaca gattgattaa tcgagttcat 2868961 ttgtccgact gtctgctgca caaacttctc acccgttccg gcgatttccg ttgattggat 2869021 agatgccttt gtaatatctg acgatgtttg tgagacttgc tggagtcctt cattcattaa 2869081 gttcagctga tgagagctgg attcaacctt ttcgctttgc tcctcgtttc cgtttgagaa 2869141 ctgctcaatc gccatcgtaa tatgctcggt ggctttactc gtctgcccgg cagatgcggt 2869201 aagctgttcg gaagatgcgg ccacattgtt caccgagtcc tgaatagcgc tgatcagaga 2869261 gcggagagat tgtcccattt cattgaagct ttccccaagc tctccaagct catcctttga 2869321 atggatttcg atcgtttcgg tcagatcccc cctgctgatc gttttcgatg attgaacaag 2869381 acgttttaac ggttttgtaa tcgaacgaac gataaacaga attaaaattc cgcctgccac 2869441 aatggaagca atcagcacaa tcattcctgt tgtcagcaca gactttgagg catccttaat 2869501 ttcatccata tacattgtgc cggctatttt ccaaccagtc agttcgtttg tagtataggt 2869561 catcttttta tcttcgttat taagagtata ctggagttca ccgctgtcat tcgcatacat 2869621 tttggctacc cagtcgcctg aaagcttttc tccagcctta tggttcttgt gggcgacata 2869681 ggttttgttt tttgttgcaa tgaaagcata accttctttt ccgaccttga tttgtttcat 2869741 ttgttctaac aatttatcaa tggtaatatc catggcgaca acgccagatc cgtccttcag 2869801 ctcctgtgca atggtaatga ccatgcttcc gtcactcgca gccacgtaag gatctgtcac 2869861 gacaatttca ccgccggcct tcatcgcatc ctggtaccaa ggccgttgtc tcgggtcgta 2869921 tccttccggc aatttttctt ttggcgcttg tacataagtg ccgttatctg cgcccccata 2869981 aattctggct actccttgat taatagatac atattgtgaa aatttagctt tgatctcttc 2870041 ttgatttgat ttccctttga atgcggatct tttaagagat tcactgaaaa aggtgactgc 2870101 tttcgctttt tctcccagat catttgtaac agttgtatta aatgtatcga cactgttttt 2870161 cgcatttccc ataatttcct gatccagctt tccgctggcg cttcggtaag agctaaattc 2870221 taatataaga atagggataa tgagaatcgc aataaatgag acgattaatt tctttgaaat 2870281 agacggtttc ttcagccaat tgataaaagt cttcatgtca cttgctcctt caggtttgat 2870341 acagtatata tcggctgctt aaaaaagttt taaaataaaa aatggaagaa gttctttttg 2870401 gctgtcttct gcctttttaa ctttcattgc ccaagctctt tgcatatctt ataaaaaaca 2870461 aggggggcta aacatgatta ttgtatcagg acaattgctc cgtccccagg atattgaaaa 2870521 ttggcagatt gatcaagatc tgaatccgct cttaaaagag atgattgaga cgcctgttca 2870581 gtttgattat cattcaattg ctgaactgat gtttgagctt aaactgcgga tgaatattgt 2870641 agcagcggca aagacgctgc acaaaagcgg ggcgaagttt gccacttttt taaaaacata 2870701 cgggaataca acgtattgga gggtttcacc ggagggcgcc ttggagctga aatacagaat 2870761 gccgccttca aaagcgattc gggacattgc agagaacggc ccgttttatg cgtttgaatg 2870821 cgcaaccgca atcgttatca tttattactt ggccttaatc gatacaatcg gagaagataa 2870881 attcaatgcc agctttgaca gaattatttt atatgactgg cattatgaga aattgccgat 2870941 atatacggaa acaggacacc actttttcct tggagattgt ttgtatttta agaatcctga 2871001 atttgatccg caaaaggcgc aatggagagg cgaaaatgtg atactactgg gggaagataa 2871061 atattttgcc catggtcttg gaatcttaaa cggaaagcaa attattgata agctgaattc 2871121 ttttaggaaa aaaggagcct tacagtcagc ctaccttctg tctcaggcga ccagactgga 2871181 tgttccgtct cttttccgca tcgtccgcta aaaagcccca tcgcctattt tccggacgat 2871241 ggggtttcaa atgcctttcg ttttcgatag aagggggctg tgccaaaata ttggttcgca 2871301 gcccactcca ttttttcaag gtcatttctt gtcacgattg gatcctggct gctccatttg 2871361 ataaagcgga caaaatagta gcctttgata ggaaccattg taacttttga gtgaggccag 2871421 ccttcaaata caaactcaat tttccctctt tttttataag aatattgaag aatgttcata 2871481 tctgtcacct cagtttatca agttacgttc ggcaaagctc ggtacgttta catccattga 2871541 ttaactatcc ctcatgcagg ctttccggaa aacaaagggt gaggcgcgtg tctctttccc 2871601 tcgcttttta tttcgcatat ggacgaatgc caagcacgcc ttcattcgat aaagccgcag 2871661 cgtgggcggg tgtgacaagc cctccggcta tcggcgcttg ttcagcgatc atgcttttgt 2871721 cataaaaaac agcctattat cccatcattt tgatatagca tgtccgggtg cgaggcccgt 2871781 caaattcgca gaaataaatg ccctgccacg ttccaagaat aagccggccg ttttccacaa 2871841 tgacatgctg tgaagctccg accgtactcg acttcatgtg tgcagctgta ttgccctcca 2871901 tatggcggtc cagctcatgt tcccacggat atacctcatc aaaccttctg agcatatctt 2871961 ttttgacgtc cggatcggca ttttcattaa ttgtaatgcc cgcagtcgta tgcggacagt 2872021 aaatcagcgc tgcgccgctc gttatacctg tttcttgaag aaacgcttcc acctcccggg 2872081 tgatatctat catttcatct cgtttggttg ttttgatttg cagtgttttc agcatttgtt 2872141 tctcctttcg tttgtccgct ctcatcgctt aattcgttct gtgttctttt ttttcctgtt 2872201 aaaccgctct cataaacccg ataaaacaaa aaaactccag tctaaggctg gagtttagca 2872261 ccatagatat attcttgctt catacggctt taagagtact gatgtcatat gcttgtgcgg 2872321 ctctgtttca atatttgaca agacgagtgc atctgatgac aatggcaatc cagagtgcct 2872381 gaacaacgcc ggtgttcctg tcagattggc cgcaatcagt gcagtatggc tctcgttttt 2872441 ccgaagatat gcaaagattt gctgatcttc cggtaaaatg agctcgtatg tcccgttaat 2872501 aaaaacatca tatgtttggc gcagcttgat caagcttttg taaaaatggt aaacggatgt 2872561 tttatcgttt ttttgcgcct cggcattcag ccatttgtaa ttctcattga ttccgatcca 2872621 cggtttggcc tcagaaaatc cggcgtatgg accagcattc cattgcatcg gcgttcgcga 2872681 attgtctctt ccctttttcc agacaatctt catcacatcc tcgtgtgatg tgcctttcgc 2872741 tgtttttgtt tcatacaggc gtttcaatgc gacatcatca tagtcctcaa tagatggaaa 2872801 agccacgttc gtcatcccga gttcctgtcc ctgataaata aacggtgtgc ctttcatgag 2872861 aaaataaaca gcggaaagcg cttttgcact ttctttcagg tacactccgt cgtctcccca 2872921 cacagaaact gaacggggct ggtcgtgatt ctccataaac aaagcattcc agccgatccc 2872981 ttccagactg tcctgccagt cagttaaaat tcgtttaaat gcaacgatat caatactttc 2873041 attgatctct acatcccaca ggccgagatg ctcaaattga aaaatcatgc tgaatatgcc 2873101 gtttttttct ccagcccaat cagctgcttc ttttgcagcg acgccgtttg cttcaccaac 2873161 tgtcataatc ggatagcggg aaaatgtgtt ttccttcagc tctgttaaca aatccataat 2873221 gccgtcagca ttcatatgat aaggaaagga agggacatag tccagtccct ttggattcgg 2873281 catgtcagga aacccttctt ttttcttaat atgcgtaatg gcatccaccc gaaatccgtc 2873341 aattccttta tcaagccacc aattgatcat gtcataaacg gcattcctca ccttttcatt 2873401 ttcccaattc aaatcaggct gttttttatc aaaaaggtgc agataatact ggcttgtctt 2873461 ttgatcatac tcccaagccg gcccgccgaa aatgctttcc caattgttgg gcgtttttcc 2873521 gtttttgccg tctttccaaa tataccagtc gcgcttttcc gagtgtatgg atgaacggga 2873581 ttctatgaac catggatgtt cgtcgcttgt gtggttcaca acgagatcca taatcagctt 2873641 catatccaga tcatgaatgt caccaagcag ctcatcaaaa tcttccatcg tgccaaactc 2873701 gcttaatatg ttttgataat ccctgatatc atagccatta tcggcattcg gtgaatcata 2873761 cagcgggcaa atccatatga cgtcagcgcc cagctctttt atgtaagaaa gcttggttct 2873821 gattccttga atatccccga ttccgtcgcc atttgaatct ttaaaactgc gggggtaaat 2873881 ttggtaaact acggcttcct tccaccaagc ctttttcata cagccactcc ttcccagtgt 2873941 accgttctta tatatcctat gtagaaaaag gtctttacag cattgctttt taagaaatga 2874001 cttgatgaca caaaaaacag ccgtttgttc cccggctgtt ttttatcaaa aatcagtttt 2874061 ttttatttct acaaaacgga tgtggtgatc ttcggcgtcg aggattttaa attcacagcc 2874121 ctccgcgtgt atcacatccc ctgctttcag ctccattttt tgcgttagaa gccagcctgc 2874181 aatcgtatca atttcttcat tttcaatcgc aatgtcgaga aggtcattca cttcgtctat 2874241 tagcgctttt ccatccatca cataatggtg ctcgcccttt ttcaggatgt gcggtgtttc 2874301 atcctgatca tactcatcgc ggatttcccc gacgatttcc tcgataatat cctctacagt 2874361 gacaagcccc gccgttcccc cgtattcatc gacaagaatc gccatgtgaa tccgctcctt 2874421 ctgcatgcgg attaaaagct gctgaacagg aatgctttca atgactctga taacgggcct 2874481 catgatttga ttcagcttta tcggctggcc gagaaaataa gctttaaaca tatctttgct 2874541 gttgatgatc cctaaaatat gatccttgtc atctttgatg acagggtagc gtgtataccg 2874601 ttcattaatg atgtgatgaa ttgcctcttc aagcgactgc tccagagaga taaccgcaat 2874661 ttctgtccgc ggaatcataa tctctctcgc tacccggttg tcaaattcaa aaatcttatt 2874721 tacatagcgg aattcagact gattgatttc tcccttttca tagctttcag aaaggatcag 2874781 ccttagttcc tcttcgctga tgacaacctg atgctccttt accgaatgaa agccaaacaa 2874841 tttcacaaga aaacttgcag agccgtttaa tgctttaata aacgggtacg tgattttata 2874901 aaaccagatc agcggctttg caatccataa gcttacagct tcagcttttt gaatagaaac 2874961 cgttttcggg gcaagctccc ccatcaccac atgcaaaaaa gtgacgatga taaatgcaac 2875021 tacaaatgtg acaatgtggt taaacggttc cggtatgcct gtcattgtaa ataagggatg 2875081 aagaaaacgt tcaaatgtag gttcaccaag ccacccaagg ccgagggctg taatcgtaat 2875141 cccgagctgg caggctgata aatactcgtc aagattggag atgattttat gtgcggctag 2875201 tgctcggctg tcaccgcttt cgatgagctg attgattttt gaacctctga ttttgacgat 2875261 cgcaaattcc gctgcaacga aaacagccgt aatgccaatc aaaacaaaaa tggcgatcaa 2875321 ttgtaaaata agcaaaaaaa gcccttacca taaatggtaa ggggccacct ccttaacgtt 2875381 aattctcatc acgaccgttt aagaaaatca tcacaaaacg aagtagttca aacagggaaa 2875441 ccagggcggc ggccacatac gttaaggcag cagcactcag cactttattt accccatttt 2875501 cttcattgtt tcggatgaat ccttctgaca caataatctg cttcgcacgt gaacttgcat 2875561 tgaattcgac aggcaatgta atcagctgga aaaagacagc cgctgaaaac agtatgatgc 2875621 caagcccgat caaattcagg ctgccgagaa gcatgcctcc taagaaaagc aaaggagcta 2875681 caccggatgc aaaattcacg actgggaaga ttttatgtct cagcacaagc gcaccatatg 2875741 actcctgatg ctgcaaggca tgtccgactt catgggaagc tacggatatg gcggaaattg 2875801 agcggccgta atagaccggc tcagataaac gcaccacccg tcttgtcggg tcgtaatggt 2875861 ctgttaaagt gcctcttacc ggttcgaccg gcacgtcgta aagaccgttt atatctaaaa 2875921 tccgtcttgc cgtttctgcc cctgtacgtc cgcttgaggc ttccactttt gaatattttt 2875981 caaagttgct ctttacttta aattgtgccc aaaacgacaa tcccaatgcg gctattgtta 2876041 aaaatataaa cagcattttt tcatcatcct ttgttcatga tcatttctct attacgatta 2876101 ttttaatgag ttttctttct cgtgtacaga aatgcgcttt ttcttccggc ttggagcaca 2876161 caatccaatc agcaaaaaga acaggcctgc tgaaaacaaa taaaaggcga aactgccggc 2876221 cagttctttc agaaaatgaa gccaggagaa gcttccggaa aagtgattat atgaattcaa 2876281 atcgaaaata aacaaaatca ccgcggatgc cgccagctgc gtaccgatta aaaccacgat 2876341 cgttctttga aagatcgtca tctttttcat cctttttgtt ttagtttatg gagaaatccg 2876401 gttttatatg ttttgtacat tttttgaaaa acatcaccgg aagtgggaca tactgttaga 2876461 aaaaagcacg ggtgtgatgg aagctatgaa agtgacgagt gaggaaaagg aacagctgag 2876521 cacagcaatc gaccgaatga atgaaggact ggacgcgttt atccagctgt ataatgaatc 2876581 ggaaattgat gaaccgctta ttcagcttga tgatgataca gccgagttaa tgaagcaggc 2876641 ccgagatatg tacggccagg aaaagctaaa tgagaaatta aatacaatta ttaaacagat 2876701 tttatccatc tcagtatctg aagaaggaga aaaagaatga aatcaaatcg gatatttatt 2876761 tcatggctca ggtggccgtt atttatccga atcggggtta ttattttatg tctgattctt 2876821 ttgttcggcc aaatcattta tatacttgag cctaagcagt tcacttcggt attcgaaggt 2876881 atttggtggg ctgtcgttac ggtttctaca gtcggttatg gagactatgt gccgcacact 2876941 ccgctgggac aggcagccgg aatactgctg attttgagcg gagcaagctt tgtcacagcg 2877001 tatttcgcta cgttatcagc ggccgcattc agcagacagc atcgctacat tgaaggaaaa 2877061 gttgcttaca aaggccggga ccacatcatt ctgatcgggt ggaatgaaaa aacaaaccgg 2877121 cttttgaagg accttcagct tgccgcccct tccaaaacag tcgtactaat cgatgaatcc 2877181 ttaacagaag gcccgcttat tgaaaacgtt catttcatac gcgggcacgc tgccgatgat 2877241 gggacactga aacgggccaa tattactgaa gcggaatcag tgatgattac tgccgatcag 2877301 tataaaagtg aaactgatgc tgatatgctg tcagtgctga ctcttttatc tgttaaaggt 2877361 cttaatcccc ttgcttactg catcgtcgag attttaactg accgttttgt caccaatgcg 2877421 gaacgggcag gcgcaaacca aatcatcgga acttcagaat ttatcagccg ggcgatgctg 2877481 cagcattacc aagtcaagtt acggccgtct aaacagcaga acggaatcaa gctgacactt 2877541 gatcagcatg tggagcttct tgctgttcct gacgaactaa agggagcggc ttacaaaacc 2877601 tgtgttctct atttccttga tcacaacaca acaattatag gcatacaaaa aaaggagggg 2877661 ccgatgcttt cccctcctct tacatacaag gtgctcgaaa cagatcaatt ccttgccatc 2877721 tagtgtaaca gaacatcctc caattctttc acgagagagg cgccgatatc caaaaatgcc 2877781 ggatcaattt ccgcgtcccg cctttccggt tcggaaaatt gattaaacag tgattggaaa 2877841 ggccctccct cggcgtgatc gtcaacatcc gcctgaaaca cctgtctcag cataaatggc 2877901 gttccgatcc ggacggccgc ccctcgttca tcgagactgc cctgtaccgc attgacggga 2877961 attcttaaaa ataaatagcc gtctctatca tcaattttat aatcaaagta gccatgatcg 2878021 tattcccagc cgccgtttat cacataaccg agcggcttca tcacttgttc cagttcttga 2878081 agcagaaaag actgcccatc tatcgcggaa ggtattggta tcatcagaat gccccttttt 2878141 tcacttatcc tgtcccgccg aacaagactt cattcagagg cgcctacatg gaaatcgttg 2878201 tttctttcgc gcggccaaca ggaaagaaag cgcattcaat taagaagtaa acagccattg 2878261 ccgctgcaag ccatacagct gaatcccaag acacataaac aaccgttgca tagagtccta 2878321 atttagtgaa aagagtatgg gttcgtttta aatgcaaaat ccgatgtacc gcatcggtaa 2878381 aaagggcaag cggcaaacca atgagaagaa aggagtggat gaaaaaatgt gacagcgtgc 2878441 cgccaaagct tgaagaaaac cctgtataca cggcatcaaa ggagataagg aaacttaaaa 2878501 tagctgcaga aaaaccggca atgatgagat gtttaaccaa ttgtttcatg aacatcagca 2878561 cctttctgat tttataaaaa gccgaccggc aaatgccagt cagctttctc acattaatct 2878621 tccagacgtt tttcaagctc tgcttttttc tcttcaaagc caggtttgcc gagtaacgca 2878681 aacatattga ctttatacgc ttctacacca ggctggtcaa acggattgac gccaaggagg 2878741 taaccgctca tcgcgcaggc tttttcgaag aaatatacaa ggtatccaaa agtatatgca 2878801 ttcagctcag gaatgttaac gattaagttc ggaacatttc cgtctgtatg ggcaagcatt 2878861 gtaccttgga atgctttttt gttaacgaaa tcaacagttt taccggctaa atagttcaag 2878921 ccgtcaagat cgttatccgc ttcctcaatt gtcagttcat gtttaggctt ctctacgttc 2878981 aggaccgttt cgaataaatc tctgcggcct tcttgtacat actggcctaa agaatgaagg 2879041 tctgttgaat agttcgctga agaaggataa atgcccttct catctttccc ttcgctttct 2879101 ccgaacagct gcttccacca ttccgcaaag tattgaagcg ccggttcgta gttgatgagc 2879161 atttcaattg ttttgccctt attataaagg acattgcgaa caaccgcata ttggtatgct 2879221 gggttatctt ccagttcaga tgttgcaaaa tctttgctcg catccagggc gcctttcatc 2879281 atgtcgtcaa tgttgacgcc gctgacagca atcggcaaga gacctacagc tgttaaaact 2879341 gaataacggc cgccgacatc gtcaggaatt acgaatgatt caaagccttc ttcgttagaa 2879401 agcgttttta atgcgccgcg ctctttatca gttgttgcat aaatccgcgc tttcgcttct 2879461 tctttaccgt atttctcttc aagaagcttg cggaaaatac ggaaagcgat tgcaggttca 2879521 gttgtcgtac ctgatttaga aatcacatta atagagaagt caacatcttc aagaagatcc 2879581 atgacgtctc tcatataaga tgaactgatg ttgttcccga taaaaatgac ttgcggattg 2879641 ccgcgttttg cttttggcaa agtgttataa aacgcgtgat tcagcgcttc aatcgctgcc 2879701 cgcgctccaa gataagaacc gccgatgccg acaacaagca agacatcaga gtcagatttg 2879761 attttttccg cgcttttttt gatgcgcgcg aattcttctt tatcataatg ttcagggagg 2879821 tccacccagc ctagaaaatc gctgcccgcg cctgttttct catggatatt atggtgtgct 2879881 gtttttacaa agtcccgcag gtatgtaagt tcatgttcgt tgaagaaagt caacgctttt 2879941 gagtagtcaa agcgtacatg cgtcattgct tgtccctcca taacggtata atgttttcat 2880001 ctttcacttt atatgaactt atctgtgaaa tcaagtcaag aagaaagggc ggaatgactg 2880061 gattccgccc tttgggttta tagagacgcg cgaaggatgg caagcacgtc atctttgttc 2880121 agtttttgga agttgccgaa gccgccgtgt tccatttcct tggctgcgat atcagcaatc 2880181 agctcaagct tttcttctcc aatattgtaa tcagcaagac gagaaggtgc accgaggctt 2880241 gtccagaacg cagacagttt atcgattcct tcaagcgcaa tttctttatc tgttttgcct 2880301 tcagtatcaa tgtcaaacat gttgagcata aggtttttaa aacggcctac atttgtatca 2880361 agcgtgtatc tcatccaatt tgggaacagt attgccaaac cgcccgcgtg cggaatatca 2880421 tatacagctg aaacagcgtg ttccattgta tgagaagccc agtcaccgaa gtatcccatt 2880481 tggagcgtgc cgtttaaagc aatagtacca gcatacaaaa tcgtttcacg aagttcgtag 2880541 ttttccagat cttcaagaag cttaggagct gtttcgatga ccgtctgcaa aacagcaaag 2880601 cacattctat cctgaagcgg cgtgttttca acattatgga agtattgttc gaatacgtgg 2880661 ctcatcatgt caaccatgcc gtatactgtt tgattttctg gaacggtgaa cgtattttca 2880721 gggtctaaaa tagagaaacg cggatgagtg acattgctgc cccatacaaa tttctcgttt 2880781 gtttcccagt ttgtaatcac ggaatcaggg ttcatttcag accctgttgc agcaagagtt 2880841 aaaacagtgc caaacggcag cgcatcctcc gctgttactt ttttgctgaa aatatcccaa 2880901 gcgtcaccgt catatttgac gccagctgcg attgcctttg tacagtcaat cacactgcct 2880961 ccgccgacag caagcagaaa atcaatgtca tgctctctgc aaagtcctat gcctttttcc 2881021 actgtcgcaa gacgcgggtt tggctctaca cctgacagct catgaacaac agcgccctct 2881081 tcttttaaaa tgcctgtgac ttgatcataa aggccgttgc gtttaatgct gccgcccccg 2881141 taaacaagca gtacattctt gccgtatcgt ttgaattctt ttcttaattg ttcaagctga 2881201 ccttttccaa aaatcagctt tgtcggatta taataagtga aattttccat agtaaaacct 2881261 ccaaatgatg ctggtaaaaa acagattttc cattgtaaca taagttgaca aaaaagaaaa 2881321 agggaagcag ccaaacggct atttcccctt tttttatagt gatgctttca aaattgacag 2881381 cacatcttct ttgttgagtg atttaaattg gccgaatgta ccgttagcca ttgccttgtc 2881441 agcgattgtg tcaagctgct catcattaat atcataatca gcaagacggt tcggagcgcc 2881501 aagacttgtc cagaatgcgg acagcttatc gataccttca agggcaattt cttcatccgt 2881561 tttacctgct tcttcaacat caaacacgcg aactgcaagc tgtttcatgc gggcagggtt 2881621 ttcagacaat gtgtgtctca tccaattcgg gaacagaatc gccagtccgc cggcatgcgg 2881681 aatatcataa acggctgata ctgcatgttc aatattatga gtagcccaat cccctcttgc 2881741 ccccatagaa agcatgccgt ttaatgcgat tgttcctgtg tacaggatcg tctcacgcaa 2881801 ttcgtaattt tcgagatcat tgatcagctt aggcgctgtt tcaatgactg tacgcaaaag 2881861 tgattcacac atgcggtcct gatacggcgt gtttgataca tgatggaagt attgttcgaa 2881921 tacgtggctc atcatgtcaa ccatcccgta gatcgtgtgg tttttaggta cggtgaatgt 2881981 attcaccgga tcaagaatcg agaatttagg gaatacgagc gggctgcccc agccgtattt 2882041 ttcttttgtt tcccagtttg taataacaga tcctgagttc atttctgaac cagttgcagc 2882101 gagagtcaat accgttccga atggcaaagc atcttttggc tgatgctttt tcgtaacgat 2882161 atcccacgca tcaccatcat acttcgctcc tgcggcaatc gcttttgtac agtcgattac 2882221 gcttccgcct ccgacagcca gcaagaaatc aatgttttgt tctttacaga tggcaacacc 2882281 tttattaaca gtcgacacac gaggattcgg ttccacacct gctaattcat gcacggtcgc 2882341 tccggcttta ttcagctgtt caatcacttg atcatacagg ccgctgcgtt taatgctgcc 2882401 gcctccgtac acaagcaata cgttttttcc gtaaggtttg agttcctccg gaagtctttc 2882461 cacttcgccg cgcccgaaaa ttaatttggt cggattccag tatgtaaagt tttgcatgac 2882521 atctcctcct tagatttttt attatgcaga atgtcctcac cacatgtaaa gcaatcagct 2882581 ctcaccgatc agcataccag atggttttat tttgcaaggt gctgggaaag aagctgatat 2882641 aagcgagggc aggccagctt ccctcatatg gagaatgcat gtatagattc tccaatatgt 2882701 cacaatctat aactgtttta ataattcatg gaggaggttg caaaacatga gtaccattca 2882761 aagaatttgt cttgtattaa ccatcattgg cgccattaac tggggactga tcggattttt 2882821 ccaatttgac ttagtagcgg ctatcttcgg cggccaaggg tcagctcttt cccgaatcat 2882881 ttacggactt gtcggaatcg ccggcttaat caacctcggt ctgctattta agccaaacga 2882941 ggaaagatca cgtgaagaag cagcaaatcc tgaaatgcga taggatatca atcacgctga 2883001 aataggattt tgcatgaaat caaaagcacc gaacattcct gtccggtgct tttttcatgc 2883061 ttattttttg ataaggtctt tgcggttgga catttcgatc cactcttcaa gcttatcttt 2883121 taatgtgttg aaaccttgtg gtgtagaagc ttcttcgctt acttgagcag ctttaggttt 2883181 tcttggtttg ctttcttttt tctcaggcgc agcttgtgtc gcacgaattg aaaggctgat 2883241 tttgcctttt tcttcatcaa cagcaagtac ttttacttgt acttcgtcgc caactgaaag 2883301 gtgctcgttg atatctttta cgaaaccgtg agtcacttca gaaatgtgta ctaaaccttg 2883361 agtttcttca tctaatgcaa caaacgcacc atacgcttgt aatcctgtaa ctttaccagt 2883421 gtaaacactg cccacttcaa attttgctgc cattcataac aactcctaag ttaaattaaa 2883481 tatctgttta tacgcaattt aaaattatat cacacatgtc ttatttccgc aaagaaaact 2883541 tttttataaa aaatcaggtt tatgcacagc aaaaaggggg taaactgaaa ataccaaagg 2883601 ctttctagta ttcccccctt ttattggatg cgaacaaaag gttcgtatct ttttttatgt 2883661 tgttttgtgc aggaagcgtt tcattctgac taacgcttct tgaagctgtt caatcgaggt 2883721 tgcgtatgaa caacggatat atccctcacc gctcggacca aacacacttc caggaacaac 2883781 tgccactttt tcctgcgtca gtagctcctc ggcaaactgt tctgaactca ttcccatgct 2883841 tttgatagat ggaaaagcat agaaagcgcc gcccggatga tgacagctga gaccgatttc 2883901 attgagcgat tctacaaaca gattccgtct tcttcgatag ctttttttca ttttttctac 2883961 gtcttccatg ccgttcttca ggccttcaag ggcggcaaac tgcgccattg cgggcgcgca 2884021 catcatcgca tactgatgaa ttttaagcat ggcatcccga agcaaggatg gtgccgcggc 2884081 aaaaccgagc ctccagcccg tcattgcaaa tgcttttgaa aagcctgaga tgactaccgt 2884141 ccgttccttc attcccggta atgccgctat acttgtaaat tcctcatcat atgtcagctc 2884201 cgcgtagatc tcgtcggcta agacgatgac atcatgtttt ttggcaaact cagcaatctc 2884261 attcagctct tccttcgaat aaaccgaacc tgtcggattc gatggtgagc agatgagaat 2884321 ggcctttgtt ttttcagtga ctgccgcttc aaaatcagca gccgttgctt taaatccttt 2884381 gtctgccgtt gtatgaacgt gaaccgggat accgcctgcc aaagaaacaa gcgcatcgta 2884441 cgcaacaaaa cacggctcag gaatgatgac ttcctcacct ggattcacaa tggcgcggat 2884501 cgcaatatcc aaagcctgac ttgcccccac tgtcacaatc agctcattat ctggcgagta 2884561 gctaaggtca aacctgttgc tcaaataacg gctgatttcc tcccgcaatg agtataaacc 2884621 cgcattggcc gtgtatgacg tatatccttg ttcaagagag agaatgcttg cttcgcggac 2884681 attccatgcg gtaacaaaat caggctcgcc gacgcctaaa gaaatgacgc cttccatcgt 2884741 tgccgccaaa tcaaagaatt tgcggatgcc ggatggtttt atttgttgta catagtctga 2884801 taaatacgaa gtcatttacg gtgacaccac gattcttttg tcgtcgtctc ctgtttcaaa 2884861 cactttgccg tcatgcttgt attttttcag gataaaatgg gttgtcgtag atacaactga 2884921 atcaagcgtt gagagtttat ccgaaacaaa acgcgctacg tcagacatcg aattgccgcg 2884981 aatcacgaca gacaaatcgt atacgcctga catcaggtaa actgattcaa cctcttggaa 2885041 tcggtaaatc cgttccgcca cttcatcaaa accgacgccc cgcttcggcg ttactttgac 2885101 gtcaatcatg gccgtaacgc cctcatgtcc gtcgactttt cgccagtcaa tcatagcgga 2885161 ataatcgata ataacctttt ctttctccag tttgtcaata attgttttca cttcatttac 2885221 agggatgccc gccatctttg cgattgtttc taaatcggcg cggctgtttt cgtctaaaat 2885281 ttctaatatt tctgtttctt tttctgtcaa tttcatttga ttcacacctt tgcaatgtca 2885341 agaaatctca tgacattata tcacgttttt tgacgaatgc taagaaaaaa cgaggagaaa 2885401 cttccgctag aattgacaat ttcagggcat aatacaacca tcaaaaaaag ggagtgacac 2885461 agaatggagg cggtttcacc aataaggcgg tttacggtcg atggagtcaa tgtatactac 2885521 gaacattatc aaaatcccgg caggcaaacg ctggtctgcg tacacggttt tttatcatct 2885581 gcattcagct tcagaaaagt aattcctctc cttcgggaca agtacgacat catcgcgctt 2885641 gatttgcctc ctttcggcca atctgaaaaa tcaagaacgt ttatctatac ctatcaaaac 2885701 cttgctaagc ttgtcattgg gattttggag cacttgcaag tgaaacaggc tgtgcttgtc 2885761 gggcattcta tgggcgggca gatatcgctg tctgctgctc tccaaaaacc tgagcttttt 2885821 tcaaaggttg tgctgctttg cagttcaggg tatttaaaac gttcacaccc gacgattatt 2885881 ttcgggaccc atatcccgta ttttcatctt tacatcaaac gctggctctc gaaagaaggc 2885941 gtgatgaaaa atttattaaa tgtggtgcat gacaaatcgc tgattgatga ggagatgatt 2886001 gacggctatg gcagaccgtt tcaggacgag cagattttca aagccatgac aaggtttatc 2886061 cgccacagag aaggagattt agaacccgag caattgaaga aaatgaacaa gcctgctcta 2886121 ttgatttggg gcgaggagga tcgaattgtc ccaatggaga tcggtaaacg gctgcacgca 2886181 gatttgccta attccgtgct gtactcactt ggccagaccg gacatctggt gcctgaagaa 2886241 cggcctgaac ttatttctga acacattgct gattttatca aataacaaaa aaaccggtgc 2886301 tgaaccggtt tttttaaggc gtgcaggagc tgctgttttt aatgaataaa agctggccag 2886361 ccacttcccg gcagctggcg atcggcagcg tttgttcaaa agaagtttca aatatttgct 2886421 gaatgctttt cgccagcaag tcgggatcgt tttcatcata gactgcctgc acgacatcaa 2886481 cagcctccgt ttcgtaaaac tcttctccat atttaaacgg gtcccatttg gcaatgatct 2886541 taatcatttc cctgaccgca tgactttctt ccatattcat caccgcttat aataaaattt 2886601 gcagttctat cttatcatag tgaagcttag aagaataaac atacatgagg gggtaacaga 2886661 atgaactttg ataaacgaga agaacgcctt ggcacccaat cggtcaaatg ggataaaaca 2886721 ggcgaattat ttggcgtgac agacgccctc ccgatgtggg tggcagatat ggattttcgc 2886781 gccccggaag cgataactga agcgttaaaa gagcgtcttg accacggtat ttttggttat 2886841 acaactccag atcaaaaaac gaaggatgct gtgtgcggat ggatgcaaaa caggcacggc 2886901 tggaaggtaa atccggaaag catcacattc agccccggcg ttgtaacagc tttgagcatg 2886961 gcggtacaag cttttacgga gccgggcgat caagtagttg ttcagcctcc agtttatacg 2887021 cctttttacc atatggtgga gaaaaacggc cggcacattt tacataatcc gctgctagaa 2887081 aaagacggcg catatgcaat cgattttgaa gatttggaga caaagcttag tgacccaagc 2887141 gttacattgt ttattttatg caatcctcat aacccttctg ggcgttcatg gagccgggaa 2887201 gatttactga agctaggcga attgtgcctt gagcatggcg tcacagttgt atcggatgaa 2887261 atccattccg atttaatgct gtacggacat aaacacacgc cgttcgcttc gctctctgac 2887321 gatttcgctg atatttccgt gacatgtgct gctccaagca aaacatttaa tatcgccgga 2887381 ttgcaggctt cagcgatcat tattccggat cgcctgaagc gcgccaagtt ttccgcaagc 2887441 cttcagcgaa atggtttagg cggactgaac gcgtttgccg tcactgcaat cgaagccgcg 2887501 tattcaaaag gcggaccgtg gcttgatgaa ttgatcactt acattgagaa aaacatgaac 2887561 gaagcggaag cctttttgag caccgagctg ccaaaggtca aaatgatgaa gccggatgca 2887621 tcatacttga tttggctcga cttcagcgct tacggcttgt ccgatgcaga gcttcagcaa 2887681 agaatgctaa aaaaaggaaa agttatttta gagcccggga cgaaatacgg gcctggcgga 2887741 gaaggattta tgcgcctgaa cgccggatgc tctcttgcaa ccctgcagga cggcctgcgc 2887801 cgcatcaaag ccgcattatc gtaaatatag ctgtaaacgc ctttacgtct tcatttgtaa 2887861 aggcgttctt aataaaggaa ttttatattt tacttctaat atttagtgtt ataatagatt 2887921 catattttat acgaaaggat ttcacacgaa tggaaattct aaaagactat cttctgcaca 2887981 tctgctttat tttgtttcct attcttcttt accaagtgtt ttggcttgga aaacctgcga 2888041 ttcttgtgcc aaaaataaac agcggtttgg tcacgctctt cgcctgcggc gcctccgttt 2888101 tatgcattat tttcccgatt catgaaatgg actacataca atacggcctt cagatgattc 2888161 ccgttatcat ttgtttattt tacattagta ccgcttccgg acttacagtc gccgcatctg 2888221 tcctatgttt tgaactgctt ttttacgaac cttccgcaat gtttgttttc actttgctgc 2888281 cttttcttat cattatccca atcttatttc agaaaaaatg gccattcatg tccaaagcga 2888341 aaaaactgct gctgtcttta ttgatcagct gcgtggagat tttcctattt ttcgcctcaa 2888401 gctggattct ttccgccttg aatattttaa attttcaaaa atcaggaatt ttcgtttacg 2888461 aggcggcagt ctcagggctt ttccgctcca gtgttcttct attaagcatc tatattatcg 2888521 aaagcatcgc cgaaaatatc gccctgcgtt cacagcttat ccattctgaa aaaatgacga 2888581 ttgtgagtga actggcagcg agcgtcgccc atgaggtcag gaatccgctg acagttgtcc 2888641 gcgggtttgt ccagctgctt tttaatgacg aaaccctaca aaacaagtcg agtgcggatt 2888701 acaaaaagct tgtactgtca gagcttgacc gggcgcaagg cattatcaca aactatctcg 2888761 atatggccaa acagcaatta tacgaaaaag aggtttttga cctatctgcc cttatcaaag 2888821 agacaagctc ccttatggtg tcgtacgcca attacaagtc agtaaccgtc gaggctgaaa 2888881 cagaaccgga ccttttgata tacggagacg caacaaagct gaagcaggct gtcatcaacc 2888941 tgatgaaaaa cagtattgaa gcggttcctc acgggaaggg gatgatccac atatcagcca 2889001 aaagaaacgg ccatacgatc atgattaaca tcacagacaa tggggtcggg atgacagacc 2889061 atcaaatgca aaaactcggc gaaccttatt attccttaaa aacgaacgga acgggactcg 2889121 gcctcaccgt aaccttttcc attattgaac atcatcacgg gaccatttca tttaacagca 2889181 gcttccaaaa aggcactacg gtgaccatta agcttcccgc tgatcttcct cactagcaaa 2889241 tcgattggaa ctttaataga ataaatgcga ggtgatgaca gatgagcacg tttgagacag 2889301 gctctatcgt taaaggattt tacaaaacag gtgtatacat aggagaaatc acggcttgca 2889361 ggccgcagca ttatttagtg aaagtgaaag cggttcttac ccatcccgct cagggagacc 2889421 ttcatcatcc aaaacaggcg gatgtgccat tttttcatga gagaaaagcg ctcgcatatg 2889481 gtgaacagac caatatcccc caccatatgg tgaagcctta tgacggtgaa gtgccggatt 2889541 ataccgaatc tctgcgggag gcgacagcac agatgagagc caaattgaat gaggatggtt 2889601 cggagtgggc aaagcgctcc cttcataatc tggacatttt agaaaaagaa tattttaacc 2889661 ggccataacc cagtctgaca aaagattggg ttttttacgt cgcgcgcttc aacagttcgg 2889721 ttaaatcgat tctctcgccg attgtgggcg gttttggctt ttcgagatac tgcttatcct 2889781 gctcaacaag cttaaaaagt ttatatgctg tgagagcatc atcaagcgct ttatgatggg 2889841 tgccggttcc ggaatctcca tactcttcgg cagctttcca taaacccgtc aatgtccggt 2889901 ctccaaaaaa gtttttgtat tcaagcgata aatctctcat ttctccctta aacgggaaag 2889961 ggatatggtt aaacatacag ttttgcttca gcactttcat atccatgttt ccccacgtaa 2890021 taattgtgct gtttttctca ggatccagct cgtttagttt acggatgaaa tcctcgaatc 2890081 tcattccttc gtctacctgt ttttgggtta tttttaaaaa tgatttgcag cgtttcgtaa 2890141 gcttcgggaa ctttttcggt ctaacatagc tagaaaacgt ctcaaccact tcatcatcaa 2890201 tcgactttac aattccggct tcaatgattt ccgggaagaa gttttgagga ctgtactttc 2890261 catcaggcat tgtaaattcg aaatcaataa tgagtaagct gtttgtcgtc accttttaca 2890321 cctgcctttc ctccgatcag aaaatgctat ctttatagta tatcaattcc ccttctcgac 2890381 atttcttcat tttctaaaaa taatgaattt tcccagccgc ttcgtttctt ttaaattgtg 2890441 aatcgtttct ttataattag taaggaaccc gaaataataa gaaggtgatg ttatttctat 2890501 ccgtaagaaa aactttgtca ttgtgtggct ggcgaacttt tttgtctccg ctagcacaac 2890561 gatgatcgtt ccttttctct ccttatacat tgagacgctc agctcttttt caaacggctt 2890621 tgtgcaaagg tggagcggct atgtgttcgg cattacattt ctcatggcgt ttttggtatc 2890681 cccgttttgg ggacggttcg gagacaaacg cggatacaag aaaatcctta tggcaaccgg 2890741 aacaggcatt gccctcagca ttttcttcat gggctttgtt acatcggtgt accaattgtt 2890801 ttttctgcgt atggcaatgg gtcttgtaac cggattcatc ccgacatctc ttgcgatgat 2890861 ttcggcacag actccgaaga gctcagctgg caaaacactc ggcacgctgc aaatggggca 2890921 agtgtccgga agcttgttcg gcccgctttt gggaggcatg cttgctgatc gtttcggctt 2890981 tacgtatacc ttttttatca catcctttgt gattttctcg tctgttcttc tcgtgttatt 2891041 tggtgtcaaa gaaaagcatc ttgcagagaa aacagccaaa cgtacgtctt actcgagaaa 2891101 agaagtgctc tcctatattt ttcaccatcc ggcgctgtgg gtcatgatgc tgttaaccat 2891161 gctgattcaa acaggcaatt tcagtatcca gcccctgctc gctttatatg taaatgagct 2891221 gcacggacct gtcaatcttg cctttttctc cggcatggca ttttcagcaa cggggctcgg 2891281 aagtttgctg ctggctagaa aatggggtga tctgggcgac cgctacggcc accgccgcat 2891341 tttaatcgga cttttgctcg ccgcctcttt cttttttatt ccgcaggcgc tcgcgtcctc 2891401 actcagcgtg ctccttgttt tcagattttt attcggaatg gcgatgggcg gtttgctgcc 2891461 atgcattacg gcagcgatcc gcgttcaggc tcccggcagc attcaaggtg aagttctcgg 2891521 ctacaatgtc agctttcgct ttttaggaaa cgtgctcggg cctctgctcg gcggaatcat 2891581 atcgagccat tttaccattt cggccacctt ttacgtcacg gcgtttctct ttttcgccgg 2891641 cgcctgcatg ctttggatca tgcagaaact tcggaaagat tcttatgcca aagcaagctg 2891701 attccgagaa aaaactaagg aatcttctaa atttaacctt ctcgtaatct caaaagaatg 2891761 gtacgatatg gctagaattt aggagaaaag agagtgacca tgttacgaaa aataatcgga 2891821 tggattttgc tcctttgcat aatcccattg tttgcattta cagttatcgc ttccggaaaa 2891881 gaagtaaaac aaatgaagtc cctggatcag gtgcttgata aaaatattga tctgaaagat 2891941 atcagccttg ttcagaacag ctacatgtat gacagggacg gctcccttgt ctcggaaatc 2892001 gtcagcgacc acgaaaaccg tgtgctcgtt ccatttaaca agattcccga ggaagtcaaa 2892061 cagattttct taacatctga ggaccgccat ttttacgagc ataaaggctt tgactttatg 2892121 ggaatggtgc gggctactgc ttctaacgta aaagacaaga aaattgacca gggtgccagc 2892181 accatcacac agcagctttc aagaaacttg tatttgagcc acgaacgctc cttcagccgc 2892241 aagctgacag agctcgcgta ttcctatcag ctggagaaaa aatatacgaa aaatgaaatt 2892301 cttgaagctt acttaaatac catttatttc aacaacggtg tttacggcgt cggttcagca 2892361 gctcaattct atttcagcaa accgctgaaa tctctcacag tgggagaaat ggcttttatc 2892421 tgtgctatac ctaataaccc tacattatat gatcctctca agcattttga ctacacgaaa 2892481 agccgtcaag aacgtttact taaagggcta aaagatgccg gggtcattac ggacaaagag 2892541 ctgaaaaaag ccgtaaaaca aaaaatcaaa ctggatgttg aaaaaagaga agacaaatat 2892601 cctgactacg tttcctacgt caatgatgaa ttcactcagc tggtgtctga atcagaaggc 2892661 tttgataaac gccttcaaaa agcatcagga aaacaaaaag aaaagatcga gaacgagctg 2892721 tccgcaagag tcagcacgct gatgaaagac ggagtgaaaa tttatactgc acttgatccg 2892781 tacatgcaaa atcaagttgt ggcacaaatg aattccaagc tcccgtatgc ggacgtacag 2892841 ggcggagcgg ctgtgattaa tcaccagacg catcaaatca ttgctctatc cggcgggaaa 2892901 aactatcaaa aatatgactt taaccgcgcc taccaggcgt acaggcagcc gggttcatcc 2892961 attaagccgc ttcttgatta cggcccttat attgaacaga ccggcgcgac aacaagcagc 2893021 accattgatg ccagcaagtt ttgcagcaaa gactactgtc cgcaaaacta caataaccgc 2893081 acttacggca cagtgacgct tgatacggcg tttaaaaatt catataatac cccggctatt 2893141 agaatgctcg accgcgtcgg catccaaaag gcattcagtt atattgagcc gtatcatttt 2893201 gccaaacttg tcgacagtga ctatcttctt ccggcggcgc ttggcggatt tacaaacggc 2893261 atgacgcctc ttgagatgac aaaggcttat acgacattcg gaaacagcgg aagctatacg 2893321 ccgagccatg cgattacaaa ggtgacagac cttaaaggaa aaacacttta taaatggaat 2893381 gataaagcga ctcaaatatt cagcgtccgc acgaacatgc agctgaaaaa actgatgtct 2893441 tccgttgtga aaagcggaac agggaaaaaa gcatatttca atgcgcctta catcggcggt 2893501 aaaaccggaa catcaaatga ttatcacgat atgtggtttg tcggcctgac tgatacgtat 2893561 acaatgggtg tctgggtcgg aaaggataca ccgaccagcg ttgaatatct tcacagcatc 2893621 agccctcagc tttccatctg gaaaggaacg ctgcaagcgg cttattaaag gatcggaggg 2893681 gatatggagt gacttcagaa caaattccaa atcgcgtttt gctgtttgac ggtgtctgca 2893741 atttatgcaa tggcgccgtg cagtttatca ttaaacgtga tccggacgga ttgatttctt 2893801 tcacatcgct gcagtcggaa acaggacaga gcctgctgaa aaaaagcggg cttccgactg 2893861 atcggtttga cagctttgtc tttattgaag acggccaagt gtacacaaag tcaactgcag 2893921 ccattaaggt tttcaggcat ctgcgaggcc catggcggct cttcgtcctt tttttcgcag 2893981 tgccgaagcc tgtcagagat atggtctatt ctttcattgc caaaaaccgc tataagtggt 2894041 ttggcaaaaa aaatgaatgt atgctcccct ccccttccat taaaaaaaga tttttaccgt 2894101 aaataaaaaa tggctaggaa gctagccatc acagattgtt gacaaaatcc taaaacggct 2894161 tcgttttagg attttgtcat ctattcagcg tgattgaaaa cttttgaagt tgtgaaacgg 2894221 cggaaacctg agaatctagc cgccgtttca ttgcgtacag agcacgaagc gcaaatctga 2894281 ccaccaaacg ctgaaatggc tagcttacac aggtaagcta gccattatgc tattataaag 2894341 cttgataaat atgaacagaa taccgataac aaaggtaaac caaaacagca gttccaatag 2894401 aatgaatcca actaatgaca tgagagaaag cgtcgaataa atccggtata cggtaaacac 2894461 aaagtaagcg agcgtgacga ccgcaaacca gatcacaatc caaatgacat tttgcaagag 2894521 cacaaaggat aaaatcccgc cgcccaaata aatcatggaa cccattctga gttttttcag 2894581 gttgttccct tccggatcat tagcaaaaaa cagcaatgac agctcggtca cggtatttgc 2894641 aattaatttc agagcggaca gaaccataaa atataaaagt gcaaaggcag caaataacgc 2894701 aagcctgatt cctttctctg aaaaataatc gagcattcca tcatacattc caaatgaaga 2894761 cagcatcttc aacgcataaa gtgaagttga gatggataag gacgaactaa aaagcaggat 2894821 cgcaatcagc ggaaaatatc ctgtcaaata agtatttttc atataaaaaa gtccctttct 2894881 ataatctacc tcatttatta tggaggactt aaaacacatt gacaagataa attattccat 2894941 tttttctcct ttttacgaat tacgggccca aatcttcaca aagcagcatt ttgagagtaa 2895001 agtagtacgc aggaatcata aaacgtaagg aagttttata tgaaaaaaac attaaaactg 2895061 caaaccagac tcaccatatt tgtttgtatc gttgtattaa tcgcattgct cattacgttt 2895121 tttacagtcg gtgcccaaac caccaaacga attagagatc aggaaaaggc cactgcgctg 2895181 cagactgctg aaatggtagc tgaagcgccg atgacagccg ctgctttaga aagcggaaaa 2895241 aaacaaaagg aactgcagag ctacacaaag cgggttcaga aaattaccgg cacggaattt 2895301 gttgtcgtca tggatatgaa cggtatccgc aaaactcatc ctgacccgag caaaatcgga 2895361 aaaaaattca gaggcggtga tgagtccgag gtattaaaag ggcatgtcca tatcagcaca 2895421 gcctctggca cgctcgggaa atcgcagaga gcgttcgtcc ctgtctacgc ggagaatgga 2895481 aaacaggtcg gtgcagtcgc ggtcggcatc accgtaaatg aaattgatga agtgatcagc 2895541 catagcttac ggccgcttta ctttattatt tgcgtcagca tcttcgtcgg tgtgatcgga 2895601 gccgttatcg tcgcccgtac agtgaaaaat atcatgtacg gacttgaacc ttatgaaatt 2895661 gcgactctgc ttgaagaacg gagcgcgatg ctggaatcga cgaaggaagg aatactcgct 2895721 gtcgatgaac atggcaaaat taaacttgcc aacgcggaag caaaacgcct attcgtcaaa 2895781 atgggcatca acacaaatcc cattgatcag gatgtagatg acatcttgcc gaaaagccgc 2895841 ttgaaaaagg tcattgagac aaaaaaacct cttcaagaca gagacgtccg cattaacggg 2895901 ctggagcttg tgtttaatga agttcctatc cagctgaaag gacaaactgt cggagcgatt 2895961 gcaacattcc gcgacaagac cgaggtaaaa catttagctg aacagctttc cggtgttaaa 2896021 atgtatgcaa acgcactgag agcgcagtct catgaattta tgaacaaact gcatgtgata 2896081 ttaggtctcg tccagctgaa agagtatgat gatcttggag attatattaa agatatagcc 2896141 atacagcaaa aatcagaaac aagtgaaatt ataaatgatg tcaaaagctc cgtactggcc 2896201 ggttttctgc ttggaaagca aagctttata cgtgagcagg gcgcaaatct tgatattgaa 2896261 tgcaacggtg tcatcccgaa cgcggcagac ccttctgtca tccatgaact tattacaatc 2896321 atcggaaatc tcatcaacaa tggcttagat gccgttgccg atatgccgaa aaaacaaatc 2896381 accatgtcca tgcgcttcca taacagcata cttgatattg aaattaccga tactggagca 2896441 ggcatgtctg aagaagacca agccaaagta tttgaacaag gctattcaac aaagggcaaa 2896501 aaccggggat tcggccttta tttcacacag caaagcatcg aaaatttaaa aggccaaatg 2896561 atcctcacaa gcgaaaagaa tgaaggaacg acattcagta ttcgcatccc gtacgaaccg 2896621 aaggaggaaa atcatgatta atgtactaat agttgaagat gaccccatgg tgggtgaatt 2896681 aaataaacga tacttaagcc aaatagatgg ctttcagctg aaaggcatcg cttcttcctt 2896741 tcaaagcgct ctgcatattt taggggagca ccatattgac ctcattttgc ttgatattta 2896801 tatgccggga aaaaacgggc tggaactgct gacggaattg agagcccaaa atgaagcggt 2896861 tgacgtgatt gtcatctcag cggccagcga gcttgacgtg atcaagaaaa cacttcggta 2896921 cggagctgtt gattatttaa tcaaaccgtt tgaatttgaa cgattccaaa cggctctgtc 2896981 tgattacaga cgaaaacaaa aggtgtattc aacccatcgc aacatgagcc aaaaagaact 2897041 ggacgccgag ctttttcaaa agaaagaagc aacagaaaaa gtgcagcttc ctaaaggcct 2897101 gacaaaaagc acgctgaagc tgatctggtc cagtatccag tcatttgaaa atgaatcttt 2897161 tacgacagaa gacttggcaa agcacacaga aatctctcaa gtatccatac gaaaatactt 2897221 aaagtttctt gaagatatac aggttctgaa tgtagaaatg gcgtacggaa cgatcggaag 2897281 acctgtgttt cagtacaacg tcaacaacag taacattaac ggaataaagc aatatctata 2897341 agaaaacgca ctgcttgctt tgagcagtgc gtttttctgt catatctctt gccaagatgc 2897401 ttgattctat tgttgataag ttatacaaga ataacaaagg gctttcacat ttttaagcaa 2897461 ataattctaa aaatagataa tttttaaaaa attatgcgaa attctattta tttcttatta 2897521 gttaaatgat aaattatgat tggttagttg atcccgaaaa actaagtcat aagtcttact 2897581 tcagaaaacg atgtcacggt tttccgcccg gaacgccttc cgcatccttc tcttccccgc 2897641 ctttcgaagg aaatactcac accacgctta ttcagggaag aatagaactg tctcagcgca 2897701 ttccatttgt tattatcaga aaattttatc gattctaaga aattgttcag gacagcccat 2897761 cacatgactg gccggatcag ctttgaacca aatttttctg gggggttata tcttgaataa 2897821 acgaaaaatc ggattggcga tgtcacttgt gatcgcagca ggcaccatat taggagcatg 2897881 cggaaacagc gaaaaaagca gcggctcagg cgaaggcaaa aacaaattca gtgtggcgat 2897941 ggttactgac gtaggcggag tggatgacaa atccttcaac caatcagcct gggaaggcat 2898001 ccaagccttt gggaaagaga atgggctgaa aaaaggcaaa aacggttacg actatcttca 2898061 atccaaatct gatgcagact atacaacgaa cttaaataaa ttggcgcgtg agaattttga 2898121 cttaatttac ggcgtcggct acttaatgga ggattcaatc agcgaaattg ctgaccagcg 2898181 taaaaataca aactttgcga ttatagatgc tgttgtcgat aaagacaacg tcgcaagtat 2898241 tacgtttaaa gagcaggaag gctcatttct cgtcggagtg gccgcagccc tatcaagcaa 2898301 atcaggaaaa atcggctttg taggcggcat ggaatcagag ttgatcaaaa aattcgaggt 2898361 cggcttccgt gccggcgtgc aagcagttaa ccctaaagcc gttgtagaag tgaaatacgc 2898421 agggggtttc gataaagccg atgtcggtaa agcaaccgcc gaaagcatgt ataaatcagg 2898481 cgtagatgtt atttatcact ctgcgggcgc cactggcaca ggcgtcttta ctgaagcgaa 2898541 aaacctgaaa aaagaagatc caaaacgcga tgtctgggtc atcggtgtcg ataaagacca 2898601 atacgcagaa ggccaggtag aaggaacaga tgataacgtc accctcactt ccatggtgaa 2898661 aaaagtagat acagtcgttg aagatgtaac gaaaaaagcg agtgacggaa agttcccggg 2898721 cggcgaaaca cttacctacg ggcttgatca agacggagtc ggcatttctc catctaaaca 2898781 aaatctatcg gatgatgtga tcaaagcggt cgataaatgg aagaaaaaaa tcatcgacgg 2898841 attggaaatc ccggcaactg agaaagagct gaaaaccttc aaagctgaat aagaatcgca 2898901 gggataagga ggtcgagccc ttatcccttg tttttctttt attttgaaat aaaggagcgg 2898961 tcaatcaatg gaatatgtca ttgaaatgct caatatccgc aaggcgtttc caggtatcgt 2899021 cgccaatgac aatatcaatc ttcaagtcaa aaaaggcgaa atacacgcgt tgctcggtga 2899081 aaacggagcg gggaaatcaa cattgatgaa tgtccttttc gggctgtatc agccggagcg 2899141 gggtgaaatt cgggtgcgcg gcgagaaggt gcacatcaac agcccgaaca aagcgaatga 2899201 ccttggaatt ggaatggtgc accagcactt tatgcttgtt gacaccttta cagttgctga 2899261 aaatattatt ctcgggaagg agccaaagaa gtttggcaga attgaccgga agcgtgctgg 2899321 ccaagaggtg caggacattt ccgatcgata cggcctgcag atccatcctg aagcaaaagc 2899381 agctgacata tcagtcggta tgcagcagcg cgcagaaata ttaaaaaccc tctaccgcgg 2899441 tgccgacatt ctgatttttg atgaaccgac ggctgttttg acgcctcatg aaattaagga 2899501 actgatgcaa attatgaaga acctggtcaa agaagggaag tccatcatct taatcaccca 2899561 taagctgaaa gagattatgg agatttgtga ccgcgttacg gttatccgta aaggaaaagg 2899621 catcaaaacc cttgatgtcc gtgatacaaa ccaagacgaa ctcgccagtc taatggtcgg 2899681 ccgtgaggta tcgttcaaaa ctgaaaagag agctgctcag ccgggagcgg aagtgcttgc 2899741 gattgacggc ataactgtaa aggatacccg cggaatagag acagtcagag atttgtctct 2899801 ttctgtcaaa gcgggagaaa tagtcggcat agcaggcgtc gacggaaacg ggcaatctga 2899861 gctgatcgaa gcggtgacag gactccgcaa aacagattca ggaacaatca ccttaaacgg 2899921 aaaacagatc caaaacctga cgccaagaaa aatcactgaa tccgggatcg ggcatattcc 2899981 tcaggatcgc cataaacacg gtctcgtcct tgattttcca atcggagaga atatcctgct 2900041 gcaaagctat tacaaaaagc cgtattcagc attgggcgtt ttacataaag gcgaaatgta 2900101 caaaaaagca cgcagcctga tcactgagta cgatgtcaga acgccggatg aatatacaca 2900161 cgctcgggca ttgtcaggcg gaaaccagca aaaagcgatt atcgggcggg aaatagaccg 2900221 aaatcctgat ttattaattg ccgcccagcc gactcgcggc cttgatgtcg gagcgattga 2900281 atttgtccat aaaaagctca ttgagcagcg tgatgccggg aaagccgttc ttctcctctc 2900341 gtttgagctt gaagaaatta tgaatctcag tgacagaatc gccgttattt ttgaaggacg 2900401 cattatcgcc agcgttaatc cgcaggaaac cactgaacag gagcttggtc tcttgatggc 2900461 aggaagcacg caaaaggaag cggggaaagc aaatggttaa acgactctct catttactcg 2900521 tgccgctcat cgcaatcata cttggtcttg cggccggcgc gttgattatg cttgtgagcg 2900581 gctacagtgt ggctagcgga tattcggctt tgtggaatgg gatattcgga gaaatctatt 2900641 atgtcggaga aacaatccgg caaattacgc cttatatttt atccggattg gctgtcgcct 2900701 ttgcattccg aaccggactc tttaatatcg gcgtcgaggg acagctgctc gtcggctgga 2900761 cagcagcggt ttgggtcggt acggcgtttg acggaccggc atatattcac ttgccgctcg 2900821 cattgattac agcggcagct gcaggaggat tatgggggtt tattcccggc attttgaaag 2900881 cgcgatttta cgttcatgaa gtcattgtca ccattatgat gaattatatc gcgctgcaca 2900941 tgaccaatta catcatttca aacgtcttga cagatcatca ggacaagacg gggaaaattc 2901001 acgaatccgc ctccctccgc tctccttttc ttgaacagat caccgattac tcacggctgc 2901061 atttgggaat catcgttgcc cttctcgcag cagttatcat gtggtttatc atcaacaaat 2901121 ctacaaaagg atttgagctc cgggcggtcg ggtttaacca gcacgcttcc cagtatgccg 2901181 gcatgagcgt gcggaagaat atcatgacct ccatgcttat ctccggcgct tttgcaggtc 2901241 ttgccggagc catggagggc ctagggacat tcgaatacgc agcagtgaaa ggcgcattta 2901301 ccggcgtagg ctttgacggt atcgctgtcg ctcttctcgg gggaaacaca gccgtaggcg 2901361 ttgtactggc agcatgcctg cttggcgggc tgaaaatcgg cgcattaaat atgccgattg 2901421 aatcaggcgt tccatcagag gtcgttgata ttgtgattgc cattattatt ctatttgtgg 2901481 cttcaagcta tgcgattcgt ttcgtcatgg gcaaattgaa gaaaaagggg gcgaactaag 2901541 tggacattgt gcagatttta tctatcattg tccctgccac actcgtctat gcggccccgc 2901601 ttattttaac tgctctcggc ggcgtgtttt ccgagagatc aggtgtggtg aatatcggcc 2901661 tagaaggcct catgattatc ggggcgttca ccagcgtgtt atttaattta ttttttggtc 2901721 aggaattagg tgccgccgca ccttggcttt cgctccttgc cgccatggca gcaggcgccc 2901781 tgttttcact gattcacgcg gcagcggcga tttcgtttcg cgccgaccag acagtcagcg 2901841 gtgtcgccat taacatgctg gcgcttgggg caactttatt tatcgtcaaa ctgatctacg 2901901 gcaaagcgca gacagacaaa attccagagc ctttttataa gacgaaaatc cccggtttgg 2901961 gcgatattcc cgtcttggga aagatcttct tttcggatgt ctattatacg tctattcttg 2902021 caatagcact tgcctttatt tcctggttta tcttgttcaa aacgccgttc ggccttcgta 2902081 tccgttctgt cggcgagcat ccgatggcgg ccgatacgat gggaatcaac gtatataaaa 2902141 tgcgctacat cggcgtgatg atcagcggat tgttcggcgg tctcggcggc ggcgtatatg 2902201 cctccacaat tgcgcttgat ttcacgcact ctaccatctc cgggcaaggt tttatcgccc 2902261 tggcagcgct tgtattcgga aaatggcatc cgatcggagc actgggggcc gccctgtttt 2902321 tcggattcgc ccaaagctta agcatcattg gatcgctgct ccctcttttt aaagacatac 2902381 caaatgtgta tatgctgatg gctccttata tcttaacgat tctcgcttta accggcttta 2902441 tcgggcgggc agatgcgcca aaagccaatg gcgtgcctta tattaaagga aaaagataaa 2902501 cattctcccc tgggaagacg attctcaggg atttttttct aatccaaaag acccccttaa 2902561 tttaattgtt tattagtttt ttaacttaaa aaaatatgaa gtgttaacgc tttcttgtag 2902621 actgtaacaa acaatacatg ggggtgtatg acatgggagc aattccaaaa acggggacaa 2902681 tttcacctga gcaaaaagac tcacaggaga aaaacctgtt tcaaaaaatt tggtcttggg 2902741 aaatcggtgt gattcctttg ccattataca cagtattagc tgttattatt attcttgcag 2902801 catattacaa tgagctgccg gcaaatatgc ttggcgggtt tgccatcatt atgattcttg 2902861 gtgtgtttct cggagacata ggccaacgca taccgatatt gaaggatatt ggcggccctg 2902921 ctattttatc tttgtttgtt ccttcatttt tagtctttta caatgtactg aattcaacat 2902981 ctttagacgc tgtaaccaac ttgatgaaaa cgtctaactt cctttatttc tatatcgctt 2903041 gccttgttgt gggaagtatc ctcggtatga acagaattgt tttaatacag gggtttatca 2903101 gaatgttcgt tccactggtt gcaggaacga tcgcggccgt tgcagccggc atccttgtcg 2903161 gatttatttt tggctatagt gcctatgatt cctttttctt tgttgttgtc ccgattattg 2903221 ccgggggaat aggtgaaggg attttgccgc tttcaatcgc ctattcacaa atactgggct 2903281 catccgccga tgtatttgtg tctcagctgg tgccagccgc aattatagga aacgtttttg 2903341 ctatcatatg tgcagcctta atgaaaaagc ttggcgacaa gcgtccagat ctaaatggga 2903401 acggacgtct cgtaaaatct aaaaaagcaa atgagatttt caatcaaaaa gaagccgaag 2903461 caaaaattga ttttaaacta atgggagcag gagttctgct cgcgtgtaca ttctttattt 2903521 ttggcgggtt attggagaaa ttcatcttca tcccgggcgc gatcttaatg attatttcag 2903581 ctgcggctgt caagtatgca aatattcttc cgaaaaaaat ggaagaaggc gcttaccagc 2903641 tttataagtt tatttcttca agctttacat ggccgctgat ggtcggtctc ggcatcctct 2903701 ttattccgtt ggatgacgta gcgtctgtga tttctatacc gtttgtcatc atctgtattt 2903761 cagttgttat cgcgatgatt ggttctggat atttcgtagg caagctgatg aacatgtatc 2903821 cggttgaatc cgcaatcgtt acctgctgcc acagcggtct cggcggaacg ggtgatgttg 2903881 ccattttatc ggcatcagga agaatgggcc ttatgccgtt tgcccaaatt tcaacccgtc 2903941 tcggcggtgc aggcacagtt atttgcgcga cagtgctgct tcgttttttc acttcataaa 2904001 cagaaagagt tccgttttat gcggaactct ttttttattt attcacaatc cgaatatact 2904061 ctcggggacc aaacggcaga tcctttgatt ccgtctcact cattctggct gacaggtggt 2904121 gctccagtaa atacagctcc cactcatcac aagccgccac accgctgcgc ccgtcatatt 2904181 gattcaacat gaatgcccct gcaaatactg agcagaataa acctgagcac atcacgactt 2904241 ttgttttcac atgaccagct cctttccttc agcttgatca ggattgattt taaatataca 2904301 aataacctct tttttgttag acttattttg aggtcaaaag aactcataaa aatccattac 2904361 agcagttcga agcgtggcag cttgcagaaa agtgcgatat aatttggact aggtcgtttg 2904421 accgtatatt ttatacatag cgcatttttc aattgagaac gagaaaagga ggtcttatct 2904481 ttgcagctct tacatcttgc tattttatcg ccttttttat ttgcttttat cattcccttc 2904541 ttggcaaaat acgcaaaaag agtgcatacg ggctggtttg tgttgatcct gcccgtcttg 2904601 ctgtttatat actttctccc aatgatcagg atgacgcaat ctggagaaac acttcgatcg 2904661 gtattagagt ggattccgtc actcggcatt aactttaccg tttatataga cggcctcggg 2904721 ttattattcg ctttactgat cacaggcatt ggctctttgg tcactcttta cagcattttt 2904781 tatttatcga aagaaaaaga acagcttggg cccttttatg tctacttatt gatgttcatg 2904841 ggcgccatgc tcggcgtcgt tctagtagac aatgtcatgg ttctctacat gttctgggag 2904901 cttacaagcc tttcatcctt tttgctgatc ggctattggt ataagcggga aaagtcgcgc 2904961 tatggcgcag ccaaatcact tttgattacg gtcagcggcg ggctgtgcat gctcggcgga 2905021 tttattctcc tttatttgat aacggattcc ttcagtattc gagagatggt tcaccaggtt 2905081 caattaattg ccggccacga attgtttatc ccggctatga ttctcatttt attaggggct 2905141 tttacgaaat cggcgcaatt tcctttttac atctggctcc ctgacgcgat ggaagctccg 2905201 acgcctgtca gcgcttatct ccattcagct actatggtaa aagccggcat ttatgtgatt 2905261 gcgagattca gtcctatttt cgccttttca gctcagtggt tttggatcgt gtccctcgtc 2905321 ggcctcttta cgatggtttg gggttcattc catgccgtga aacaaactga tttaaaatcg 2905381 attttggcgt tttcaaccgt cagccagctc ggcatgatca tctccatgct cggagtcagt 2905441 gctgcggccc ttcattacgg acatacagaa tattatacag ttgccgctat ggctgccatt 2905501 ttccatttga tcaaccacgc aacctttaaa ggaagcttgt ttatggcagt cgggattatc 2905561 gatcacgaaa caggcacacg ggatatccgg aagctaggcg gcctgatggc gattatgccg 2905621 attactttta ccatttcctt aatcgggaca ttttcaatgg ccggcctacc gccgtttaac 2905681 ggatttttga gtaaagaaat gtttttcaca agcatgcttc gcgtgacaca ttttgacctg 2905741 ttcaacgtgc agacatgggg cgttctgttc cctcttttcg cctggatcgg aagtgtattt 2905801 acgtttatct acagcatgaa attgctgttt aaaacattca gaggaaatta ccagcctgaa 2905861 cagcttgaaa aacaggctca cgaagcgcct gtcggtatgc tcgttccacc ggtcattctt 2905921 gtcgctttgg ctgtcagtct cttctttttc ccgaatatat tgtcgtacag cctgatagag 2905981 cctgcgatga actcaatcta tccgacactg cttgacggcc atgagaaatt ccacgttcac 2906041 atttcacagt ggcatggggt tacaacggaa ttgctcatga ctgcgggtat tgttgtgatc 2906101 ggaacaattg gttatttgtc gctgaataag tggaaaggaa tctataaact gtttccttcg 2906161 aaactcacac tcaaccggtt atacgataag cttttgacta tgatggagaa aggctcttac 2906221 cgggtcacaa aacaatatat gaccgggttt ttaagagatt atttgctgta tatcttcgct 2906281 ggtttcatca ttctgatagg cggagctttt gccattaaag gcggattttc atttaaaacg 2906341 gaaggcatgg ctaaaatcgg tgtatacgaa atcattttga cgcttgtcat gatcagcgcc 2906401 acagtggcga ctgtttttgc taggtcaaga ctgacggcga tcattgcact cggtgttgtc 2906461 ggttatacgc ttgcattgtt ttttgtcatt ttcagagcgc cggacttggc attgactcag 2906521 ctcgtcattg aaacgatttc tgtggcactg tttctgcttt gcttctacca tttgccgaaa 2906581 ctgaggctga aaacaaaaac gagaacgttc cggatgacga attttatcat ttctttaggc 2906641 gtcggtgtta tcgttacact gctcggcatc gcatcctcaa gccagcggac aaaagacagc 2906701 attgcgtcct tctttgtcaa acacagccac gatctcggcg gaggggataa tgtcgtcaat 2906761 gtcattctcg ttgatttcag gggatttgat acaatgtttg aaattacggt attaacgata 2906821 gccgctctcg gcatttacag catgattaaa acaaaagtaa aagaggaggg gaaaagcggt 2906881 gaatgaacaa aaaacaaatg acttgattct tcaaaccgcg acaaagcttg tatcctttat 2906941 cattttgctt ttctctttct atttattttt atcagggcat aacgcgcccg gaggaggctt 2907001 tgtcggcgga ctgatcacgt cctcttccat cgttctcttg ctcttggcat atgatttaaa 2907061 aaccgtgcgt tcccttttgc ctgtcaattt catttatgtc gcgggagccg gccttctgct 2907121 cgctgtatta acaggcgttg gctcctttgt cttcggggct ccttttttaa cccacacatt 2907181 cggatacttt cagctgccga tccttgggaa aacggagctc gccacagcga cgatatttga 2907241 tttaggcgtt tatcttgttg tcgtaggcat aacgatgacc attattcaaa cgattggaga 2907301 ggaagaataa tggaaatctt aatggctgta ttagccggta ttatttttat ggctgctacg 2907361 tatttgctgc tgtctaaaag cctgcttcgc gtcattatcg gaacagcact gttaagccat 2907421 ggcgttcatt taatgctttt gactatggga ggattaaaga aaggcgccgc tccgattttg 2907481 agcgagcatg ccaaatcatt tgtcgatccg cttccgcaag ccctgatttt gaccgcaatt 2907541 gtcatttctt ttggcgttac gtcattcatc ctcgtcatgg cctttcgcgc ttatcaggaa 2907601 ttgaaatcgg acgatatgga tcaaatgagg ggaaatgatc aacatgaata attttgttat 2907661 tttgccaatc ctgatcccgc ttttgtcggc tattcttctg attttcatga cgaagaatct 2907721 tatgctcatg agaatcttca gcacggcggc atcggccatc gggattgtga ttagcggcat 2907781 acttgtacag actgtcttca caaaaggcat ccagacactc agcctaggcg gatggaaagc 2907841 gccgtacggc attgtgcttg ccgcagacca attcgccagc cttctcgttc tcacaacagc 2907901 gatcatcggt ttattggttg ggctttattc cttccgttct gtcggtgaaa aacgggagcg 2907961 ctccttttac tactccggcg ttcagttctt gcttgccggc gtcagcggag cgtttttaac 2908021 aggcgattta tttaatatgt acgtattttt tgagcttctg cttattgctt cctatatgct 2908081 gattgtatta ggcggcacaa aaattcagct gcgggaatcc cttaaatata ttgtgtttaa 2908141 tattgtatcg tctgccctgt ttgtcatagg ggtcggcttt ttatacgctg taaccggtac 2908201 gttaaacatg gcggatctta gcgtgaaaat cagcgaatca ggacaaaccg ggctgatcac 2908261 tgtgattggt gtcctgctgc ttttggtatt tggcatgaag ggcggaatct tccccctcta 2908321 cttttggctt ccaggctctt attacgcgcc accggcggca atctccgcgt tgttcggcgc 2908381 tttgctgaca aaagtcgggt tatatgcgat tacgagggtt ttcacattga tttttattca 2908441 cgatacagcc tttacccatc agttgatgat ttggctggcg gcgctgactg tgatttttgg 2908501 tgtgatcggt tcactcgctt attcgaatgt catgaaaatt gtgatctata acattattac 2908561 cgctgtcggc gtgattttgt tcggtgtggc agtacacacc cccgcatcca ttcagggcgc 2908621 gatctactat ctgattcacg atatgctgat taagggcgct ttgttcatgc tggcaggtac 2908681 gctgatcgca ttgactggaa ccgcgagcct gcataaaatg ggcgggctga tcaaacgcta 2908741 tcctgttctt ggatggatgt ttttcatttc cgctatttct cttgcaggca ttccgccact 2908801 gagcggattt gtcggcaaat ttaaaattgc agagggcggc ttcgcagaag gtgaatttac 2908861 gatatccatg ctgattctgc tttcgagtct gcttgtactg tactctgtgc tgaggatctt 2908921 tatacatgcg ttttggggcg aagaaaaaga aacgccaaaa ccaaatcatc gaacagctaa 2908981 aggacttctt tatccggcag ctatttttct cttgctgtcc cttctcttcg gattgggtac 2909041 agaatgggtg tcgccttacg ttgatcaagc ggccgagacg ctgctgaatc cggaaaaata 2909101 tatcgaagct gttctgaagg agtagatcgc atggcatttc aaattttatt aaatgtgttt 2909161 ctcgcttttt gctggatgtt cttaagcaac agtccaagcg ccgcaggatt cattacaggc 2909221 tatattctgg gaatgctctc tctctttttc ttccggcgct ttttcactcg ccagttttat 2909281 ctatggaaat tgatttctat tatcaagctc tgtttcattt ttataaagga actgtacctt 2909341 gccaatgtca gtgtgatgaa atcagtctta tctccaaaac tgaatatcag accgggtatt 2909401 tttgctttta aaactgaact gacgaaggac tgggaaatca ccatgctttc tctgctcatt 2909461 acattaacgc cgggaacctt ggtgatggat atttcagatg acagaacaat actttatatt 2909521 catgcaatgg atatcgagga tgcggaaaaa gcgatttttg acattcggga gtcatttgaa 2909581 aaagccatac aggaggtgag ccggtgatgt ttacgctgat cctgcaaatc gcgctcggca 2909641 ttatggcagt gtctaccttt ttgtatgtca ttcgtgtcat taaaggtccg actgtgcctg 2909701 accgggtcgt ggctctggat gcaatcggca tcaatctgat cgcaatcacg gcgcttgtct 2909761 ccattttgct gaaaacaagt gcgtttttgg atattatttt gttgctgggg attttatcgt 2909821 ttatcggaac gatcgcattt tccaagttcc tggagaaagg agagattatc gaaaatgatc 2909881 gaaaccgcta aggtcgttgt ggctgtattc attttgctgg gtgctcttat atgcctcatt 2909941 gcttcatttg gcgtacttcg ccttcccgat gtgtttacac gcgctcatgc tgcttctaaa 2910001 ggctcaacat taggtgtcaa tatgattctg ctcggtgtct tcttctattt gtggtttgtg 2910061 acgggggagc tctccgctaa aatcctgctt gggattctct ttatctttat tacgtcgcct 2910121 atcggcgggc acttgatctg ccgtgctgcg tataactccg gcgtcaagct tgatgagaga 2910181 agtgtgcaag atgactataa cggaatcaga aactttgtga ttaaacgaaa agaggattct 2910241 tatttataaa aataagcagc cggacaggca gagttccggc tgttttttta tttcttgatg 2910301 acagccagcg tgcatctgga tatacagatc agcctctctt gctcgtcata tatgtgaata 2910361 tgatagacaa tcgtcgttct gcctatatga acgggctcgg ctatcgcctt taccgttcct 2910421 tcctttacag attttaaatg gttggcgtta atctccaaac caacacaagc ttgcgttgta 2910481 tgatcaatca ggttctgtgc acctgcgctc gccgcggttt ccgccagggc cactgaagcg 2910541 cctccatgca aatatccgaa cggctgtacc gtccgatgat ccaccggcat gaccgcaacg 2910601 catcgttccg ctgtgttttc aacaatctca ataccaagcg cttcaagcaa tgtgtgcttc 2910661 atatccatct ctacaccccc caacatttaa agtacaccgt ctgatttcgc aatcaaaacc 2910721 gcttccgtcc gtgaaccgac attcagctta ttgaaaatcg atgtcaagct gtattcaatg 2910781 gaccgcttgc ttaaatgaag ggcatctgcg atttcttggt ttgtaaatcc cttttcaact 2910841 tcttgaagaa tcaggcattc tctaggtgtg agcacatctt gttctttttg agaggaagga 2910901 gccggctttg ttttttgctg agtcatcagc tgtttaaagt aagcaaaatc gactaaaatt 2910961 tctccgttga gtacgtggta tatgtattgg gtgatctttt ctttagattc cgttttgctg 2911021 atggcaccgt gcagacccgc acgaatcgct tcctcgaaat aatcctcgac ctcataaccg 2911081 gtatacacga taattttaca atgaggattc tcttgtaaaa tctgtttaga aagctccatc 2911141 ccattgacct cgccgcctag attcagatcc attaaaatga gatcatatga cgagaaatca 2911201 tgctgcttga taaactgttc gctcggttca ggactgagac aatcaacaga caaattcgaa 2911261 tccgtttcca aaattgtctt ggtgccttcc atgacagccg gatggtcatc aatcactagt 2911321 atctttttca tgttttcctc ccttttactc actcttttcc attttataaa aaagacttgg 2911381 cctgtgccaa gtcgtttccg ttataaatcc attacaattc gatttcaata tcagccttaa 2911441 agccctttcc ttcacttgtt tcaatccgaa ggcgcccatc taaagccctg actctctcct 2911501 taatgccaga aagccccatg ctcatggaat gctcagtatt tttttcttga tcaaacccaa 2911561 cgccatcgtc ctcataatga agaacgattt tgttttgaat actgatgagc ataatcagca 2911621 catccgtcgc ctgagagtgc ttgaccgcat tagacagaaa ctcttgaatg atccggtaca 2911681 aattcagctg cgaatccaga tcaagggaag ccgtaaatct cccggtattt aaacggatat 2911741 gaaacggaac ccgctcctgc tgctgcgcca ccagcttcga cagcgccttc accaatccaa 2911801 gatcatacag aagctgcggc cgcagctcat gacacgtctc cctcgtcatc gaaatcacat 2911861 cagacatctg ctcattcatc tgtacaagct tgtcctgcac ctcttcacgg cacggattat 2911921 catccttctt gaaatcaccc aaaaacagct cacactggcg ttttaaggaa atcaaatcct 2911981 gaagaaccga atcgtggaga tcgcgggcga gtcctgaacg ctgtttttct tcgattgcaa 2912041 acattagctt tttcagccag atggggttgg ttccctcttg ttttaagtcc ttcaaatgtt 2912101 ccatgagctc ctcaatatgc aggacatttt ccatggacac acttgtataa aaagacagtg 2912161 ttttcagcca cgatatttca tcacgtgtta gccggggagt gttaatatta gataaacaaa 2912221 gcagaacata agaactaccg cctcgttcac caactttcat aagaaagcct tgattgactt 2912281 ctataatttt cccaatttct gaagttacgt tttcaaattc ctcttgataa aaattccagt 2912341 ccggtccaac ttcatgctta tctaaaaata tcactttgtg atcaggagta acctcaaagg 2912401 tataagcttt gcttacaagc aaaacatcca gtatagtatt tttcagttct ttaaaaactt 2912461 gttgaagaga agttacaccc ctcattagct gagtatattt aaaaatactg tcctgatagt 2912521 tgaatttttc ggagaaacgt tttaaccgaa atttaaaatc catgacctct ttaaaataaa 2912581 agacagcgaa catgacaacg aaaaaaaata cagtttgacg cacagggttc atctggatgt 2912641 ccattacatc aaacagaact aatgcaccaa ctattagaag agttggtatc atggcaagta 2912701 gagcatagta tctcattctt cctaagataa actctatatc aaacatctta ttggctacaa 2912761 attggtatac taacccgaac ggaattagta ctagtaatga cgccgaagct aatgccggga 2912821 aaatataatt acctgtaaat attattggaa gaacaaaaaa tatcaaaaaa ggcgcaaatg 2912881 aaagagtgtt tgttaaaatt agtaatttaa gaataaacga atgctcagca tatttatatt 2912941 tattaagatg taagtatatc gctgaaaaag aaaatagagt caaagttgca aaagaaacca 2913001 aattaagagt tgctaaaaaa tcaatatcta cttgtaaata gtcttgaaaa aactcaatac 2913061 caagattaaa tattggtatg atataaagaa aagaaattct attcaaaaaa gttttaccta 2913121 tttctccaag gtatctttgt ataaattgaa gataaagaat aggagaagat ataaaagtaa 2913181 acaagttaat ataccgattg attatatgtc ctctaaatgg tccgcctgca cttatatatg 2913241 ctatcgaaat gtctaataac aatagaataa gaatataggc agcaaatgat ctcctttttt 2913301 tatttacttt aagtatataa aaaatacata ttatgcttaa aaaataaaaa aacaaaggaa 2913361 gtacgaacag aaaaaaacta taaggtctat ttagagtaac taaatcaaaa tctttgagat 2913421 gaatcttttt tccacttctc aaaatatcca gactgttaat atgactcaaa tatccccatt 2913481 tcaaatgttt gtctgaaggt ttttctttat taatttttaa tatgatgtct ccctgtctca 2913541 gaccaacaaa ttgtccatat gaagattccg atatttcttc tatcataaat tgacttttat 2913601 catttttatg aatcttagtc ccaataataa ttccattcat actgatataa gttgtatagc 2913661 ttatataaag gatactcaaa acaattacag ctattgtgaa tttttttatt aagttcttca 2913721 atattaatcc acctattaat caccccattg acgggttatt ggatcagcca gataataatc 2913781 attataagct ttaattattg tttcagtttc ttgcacatca aaacctataa ggcaggcttc 2913841 tttatttttc aattttttta aagcctcagg ataatttaaa aagtagttaa ttaggtcttg 2913901 catcttgtat ccccctttgt ataacttaat aagcattcct ttattagctc tttttttctt 2913961 tatctaaatt taattgttct atagcagaaa tacatttctg tttatatatt tccaataata 2914021 ccgaaatgta ttgagtaact cccgctttaa ttaatttttc ttggaatttc tctttatcaa 2914081 gtaacgattt ataatataag tctttatgtg aaattaagta taataaatct tccgaagcat 2914141 cattaaaaag gcgcttaaga tataagtaaa tcagtgtatg tttgtttttt tcaatatcac 2914201 tgcgatttcc ggataaaaga acataataat ctccagaaat ttgagctata atccctttat 2914261 agtaggaata tctttcaact gtttcattat attctcctgt agccaataaa acacctgcta 2914321 catttgctag tgcaatcaga cttccacatt ttaatctaat tacttctaaa ctttcatctt 2914381 ctgttttaga tttattagtg atatcgtcat gttgaccttg catggcctcg tttacgtatt 2914441 ttaaaacata tttaaaaatt agaggattgt tatttaatga ataaatactc gttaatccta 2914501 ctgtatacaa ggaaagtgct gcatttaacg actccgagcg attaattttc atccataatg 2914561 catggtgatt atcttcatct tcaagatcat ccataatatc tgatgaaaga ataagaattt 2914621 ctattcccgc gccaagcctt gttgcaacat ctaaattctc ccctccaaaa acaacataat 2914681 gtaagattgt ggattcagca aaggagaatg tttctttaga atcaataaat gagtaaagaa 2914741 gttgtgacaa atcctcgtta aatatgtttt gctccacaat ctccttcatt ttctccttga 2914801 tccggacaga atctaaacat atctgctcaa taacgacttc ccccctccca ttccatttta 2914861 ctaaatggga catttaaagg acagcaggtt tttcgttttt taacaatcat ataatacttt 2914921 atccatttat tgtatcggta gaacgaaaaa aaagacttgt ttccaagtct ttttcacgaa 2914981 attttcattg cataattgta tttatcgagt tgatcaatgc ttttgttaat gtttcgtaat 2915041 gaatctgtcg tttctttaat atcaagttcg agtcggaata acaattgttt tacttcttca 2915101 agtttctttt ccatcgtttc cacactcctt tttttgaaag atcaatgaat tgtgtatggt 2915161 gaacgagtcc taggtatttg atctgttact aatagtgtgt ctgctttcgg ctcatttttc 2915221 accgaaaagt atgcaaaaaa gtcctgcgtg acaccgcaaa tctcaatagg tccttatact 2915281 caaaggaatc acaacaagaa cgggactatc tttctatgcg aaagagcgtt tatatgtgct 2915341 gaaattgaga aagattctta atctccttga ttttaacggg tttcgcattt tcactaagca 2915401 agactatagt ccttcatacc gtattttcaa aattgaatat gcgattcttg gcgtttcctg 2915461 accgacaaac accgaaaaag accgcaacgc taaagttgtg gccttttcgc tttgtcatat 2915521 tcggcaatta gggatctata catatagaaa catccttttt tgcgaggtgc tcccatgaga 2915581 tatcgttatc cctggtttta cgtgtatccg tatgaggtac gccgtccgcc cgctcctgcc 2915641 aacaatattg atacctttat ccgttcagcg aagcaggccg cagggatatt tgcggatgcc 2915701 cagctcgttc tcagccgcat tgcgggctcg cgggagcttt cgcgccgcat tctgaccgca 2915761 gccgaacagt ctgataaaca aactataagg cgcctgatca aacaaatggg cgtccggcat 2915821 gaagtggata cggtctttaa tcccgacggc atctatatca gccttatcgg aacgcaaagc 2915881 cgaatgattc ttgctttgcg gtggtcagag gaccgcaatc attttgcgtc cataagatta 2915941 tgacaccatt ccagagcctc taaataacat tcatacgctt cttctttgtc cagttgattg 2916001 cctaattctg agcaagtgtc ccagttgttg ctttcaatta atttcacaag ctcaagcatt 2916061 tggtagtagt cgttttgatg gcctaataat gcttgcccga cttcatcttt taaaggcaat 2916121 tcttgaacaa tttcctctat ttctctatgc aggagggtgt ctatgagaga aaacattccg 2916181 atcagcatat aagaagcagg ctgcggccgg gatgtctttc tcgccagcag ttcgcaaagc 2916241 tttgctctta tcagagaaat cttaatgatt tcgtgcttgc tggaatgccc tttcctgctt 2916301 aaatccttaa aggaaagaat atatatccac cgtttgattt cattaaatcc cagcagcata 2916361 atggcctgtt gaatgctttc aattttctgg ctcaaacggc tgtgggatga gtttaaaaat 2916421 tttaaaattt gataggacag tgataaatcc cgctctatgt actctgtcac acgctttatg 2916481 ttaggctgct ctttactcag ttcgttaagc agttcatagt aagaatagaa atgagtcgat 2916541 aggtcatgcc cgctgatgat gcgcggctcg ctgaaaaagt agccttggaa taattgaaag 2916601 ccgtcttgga ccgcctgttt atattctttt cgggtctcta ctttttccgc taaaaaaatc 2916661 aggccgcggc agccgtaggt ttgcaaaatt gttctgcgtt ccattcgtgt tgttttgaga 2916721 aaatcaattt tcaatatatc aatatagctc atgagttttt ccagtaagtc ctcatcttgc 2916781 ggatttattg cataaaaatc atcaagcgcc agcatatacc ccattttttt caattctttg 2916841 catctagaaa tgagggccgg cgtgatcggt atatcttcaa ggatttcaat gacaagctgt 2916901 ttcggattga aggaggtggg aagattcgaa aacatcaggc tttccgtaaa attaacaaaa 2916961 cagcgtttcc cttccgtcag cttctcaatt ccgatgttta aaaagctgtt gatcaccaaa 2917021 tctgttgttg cctgatcgcc gtctttagcg ctatacacgt tctcttcgct ttctctatac 2917081 agcagttcat aagcaacaac ctgttctttt ctattaaaaa taggctgtct tgcaacaaac 2917141 accctcattg atttatcccc cttacaatac gcgcggcttt cacccctaag tatatcaaat 2917201 aatttgacga aaattgtcta aacatgaaaa ataatatata cataaagaaa actggccctt 2917261 cgcgaatgaa aggccagttt ttctttattc ttcctcaagc tcttcttcaa ttctgctttt 2917321 cacttcgtgg atccgctgca ttttattgct ccagcagtcc tcgcttaaat caaccgggta 2917381 ttcctccggc ttgctgattc tcttatattc ctcccaaagc aggctgaggt tatcctgcac 2917441 atactgctgt atgtctgaaa tctcagggtt ttggtagcaa agaataccct tctcaaaaat 2917501 cagttcatga agatccttcg cataaaaatt cgtgacaaat ttgctgatga atgtatgaac 2917561 cgggtggaac attctgagcc gcttctgatc attcacctgc tcatcataaa gcgcaatata 2917621 gtcgccttca gaatgatggt tggactgatt aataatgcgg tagactttct ttctgcccgg 2917681 tgtcgtcact ttttcaggat tggacgaaat tttgatcgtg tcgaccattt tcccgtcttc 2917741 ttcaatggca acgagtttat aaactgcgcc gagagccggc tggtcatagg cagtgatcag 2917801 cttcgtaccg acaccccaga catcaatgcg cgctccctga gcctttaaat tcataatggt 2917861 gtgctcatcc aaatcgcttg aagcaatcac cttcgcatct gtaaatcctg cttcatcaag 2917921 cattttccgg gctttttttg acaggtacgc caaatcgccg ctgtccagac ggatgccaat 2917981 gaaattaatg cggtcgccga attccttggc aaccctaatc gcgttcggca tgcctgaacg 2918041 aagcgtgtca tacgtgtcaa ctaagaagac gcaatcctta tgtgtttccg cgtatttttt 2918101 gaaagctgta tattcatcgc ggtaagcctg cacaagcgca tgcgcatgtg tgccggaaac 2918161 cgggatatta aagcgctttc cggctcttac attgcttgtc gcgctaaagc cgccgattaa 2918221 ggctgctctc gctccccaca tggccgcatc catttcgtgc gcccgtcttg ttccgaattc 2918281 aagcgcaact tcatcaccga tgacgccttt aatccgggca gcctttgttg cgattaatgt 2918341 ttgatagttc acaatgttga gcaaagctgt ttcaatcagc tgcgcttcta ccaggggtgc 2918401 ctccaccctc ataatcggct cattgttaaa aacgagttct ccttctttca tggagtaaag 2918461 tgaacctgta aaagataagc cgcgcaaata ttcaataaaa tcttcatgat acccgagttc 2918521 atcctgtaaa taactcaaat cgctatccgt aaacttgaaa ttttccaagt attcaatggc 2918581 tttttccaag cccgcaaata cggcatagcc attttcaaac ggaagccttc tgaaaaacag 2918641 ctcaaaaatc gctttctttt catgaatgcc gtctctccag tacgtttccg ccatattgat 2918701 ctgataaagg tctgtatgta atgacaggct gtcatcttta aatccgtact ctaacactgt 2918761 ttttcccctt ccttactctg ccacttgcgc tccgatgctg tttgcaaaat gggaaagagc 2918821 ccatgcgtgc ccctcctgat taaagctggc aacagcttgt ttatgcacaa caatccgaaa 2918881 acctttgttg tatgcgtcaa cagctgtatg caacacacaa atatctgtgc agacaccggc 2918941 aagatgcagt tcgccaatct gccgctctct gagtttgagc tctaaatcag ttcccgcaaa 2919001 agcagaatat ctcgtttttt ccatgtagta aacattaggt tcatgttcat gtttctgata 2919061 tagaggcaaa agctttccgt acagatcttt tccttccgtg ccttttatat tatgcggagg 2919121 aaaaagacgg gtttcagggt gatattgatc cccttcatca tgagaatcta ctgctaatac 2919181 gacgtaatca ccgtttgtga tgaattcttt agttaaattg acgatcgcct cttcaatcat 2919241 tctgccgggc tccccgcagg tcaattttcc gtcactcgcc acaaaatcat tcgtataatc 2919301 aatacaaata agtgcttttt tcatagccgg cctccccgcc atcagtatga gaacattata 2919361 tcttatctcc agttgtaagt gaattgccat gaacaaaaag acaaacggtc cgtttgtctc 2919421 ttacgatttc agtactgacc gattataaat gtcgtcctga atatatatca attcacgatt 2919481 cacagcgata tcagccgcaa tgacgatgcc taagggcgta tgaaactgga gatcagatac 2919541 aatcttgaaa ggcactccgt accggctcgc catttggata taagaagagt aagactgata 2919601 ctgaagctct ccattaatca aaagggtgac gttatggctg tttttcagct cgtgctctgc 2919661 ctctttatac ggtttgcttc taagcacctg tcctttcgtc agtgccaaaa cgactctttc 2919721 tcttaaagag cctaaaaaca aatggcgctc gtcaggcttt gtctccaaag gcccatacat 2919781 tccttgctgc aaatagagat ccattttatc ttcactcaaa agcctgtcct cccgtcttgt 2919841 ttgtcttcat tatcacctga tcaggcagga gctaaacttt caagcgccgt ttacatttct 2919901 gttacccaat gaatgatttt tttggccagc tcaccagcag gggtttcctc tgtatgccgg 2919961 cgcaacgacg cttccagccg ttcaggcaga gttgctttat cttcttcata ggaaatgatc 2920021 gtgctccact ccagctgcgg taccgctaca agcgtgcgca gttcttttct gttttcatgc 2920081 agatacacgt ccgtgatcat tccggtttgc gtattgatat ttgcttttct gattttcata 2920141 acatgacctc tctattcaaa gactacccat attatacaat aaaaaagcaa cagcctcttg 2920201 tgaaaaggct gttacccgtt aaacgaaact gtttcatcag tgatatcggc atctttgaag 2920261 agagttttac tcgtttggtt gttaatcttc acaaaatcac caagctgaaa tgtgcctgac 2920321 cccgcccctg aatgagcgac gcttttgggc gaaatcgcaa atacgtctcc aaagcttgcc 2920381 gcggcattat ccgtaactga catgatataa atcggcccca caattgcagg catttcccca 2920441 cctccgcatt gatttacagc atcatatgca aggagccgat aatggtgccc gcctattcag 2920501 ctggctttgc gttttcctcg agtcgtgacc gctggcgcag cttgatcaag cggacaatat 2920561 tcaggaagaa cgccttcact accgcataaa ccggcaccgc taaaatcatg ccgagaattc 2920621 cgccgaagct tcccgctccg attaatagca aaataatcgt aagcggatgg gtattcagcc 2920681 gctttccgat cacaagagga gacagcaggt ttccgtccag ctgctgaacg atgacgacca 2920741 caataatcgc aaacagcgct ttggccggcg agtccataaa accgacaatg acagccggcg 2920801 cggcaccgag aaaaggcccg acatagggaa tgatattggt aatcgccatg acaatcccaa 2920861 gaatcagggc atacggcagt ccggcaatta aatagccgat aaaacacgct gttccgacaa 2920921 aaagacagat taacagctgc ccctggaaat atgccgcaag cgtatcggat aaatctttaa 2920981 aaatctttaa gccttctgtc cgataagaag ccggtagaat ttttactgcc aaatgcggaa 2921041 agcggtgtcc gtctttcagc atgtaaaaaa ggataaatgg aacagtaata ataacaagcg 2921101 tgatgtttgt cacgacacca aacaccgcag ataaactgga cgtgatattt tgcggcaggt 2921161 tttggagaaa acttgtcaat gactgttcaa tttttgatat cgatacataa tcctggttca 2921221 tcatccaggt aaaccattga gaatgggaca aatcctttgt cagcgcctga atctgtttta 2921281 tataatcagg aaggttgtta aacagccctg tcacctgtgc ggtgatgata ggtccgactg 2921341 acgctgaaat aaaggcaagc aaaccgataa acagtaaata gatcaataga atggataatg 2921401 tccgcggaat ttttttctca agcaggcgga cgaccggatt aaatatgaaa tacaaaattc 2921461 ccgcaattag catcgggaaa aacaatgtcg agataaaaac aataaacggc tgaaatacaa 2921521 atgaaacttt tgttgctaca aaaataatca gcaaaacaaa taaaatctgc aatgtccaaa 2921581 aatggacttt tgatttcaac aagctttgtt cctcctagtt tttctttgtc tgtcagataa 2921641 aagaacttat accccatcat tgtaacaaaa atgaactcat atcagaactc ttaatataat 2921701 gaaaggagtg ttggtgatga aggccgtgac atacgataca gattcagaac tggcttatat 2921761 ctatgttctt cctccgaaaa agaacaggaa tgtacggact gaggagctca gagtcaatga 2921821 ttgtctcctg ctggatatca gccaagatgg caaaatcgcc ggattcgaat gttttggtga 2921881 ggcagcacac ctctgtgccc catttgccgg gaaatcccgg ctgtatgtaa aagattcaga 2921941 cggttatcat tttcgggtct gccagcatgc ttcagtccgt tcctgctata cggtgtaccg 2922001 tgtcactttc tgtttttcag atggtgacta tcaggaattt gccggctttg accttgatgg 2922061 aacaatgtat catagtgcgt ttttacagcg cttaactgaa aaataggacg tcctgttgta 2922121 cgcctatttt tcatgcgcaa gcactgttag acccgctcac tgtaatctgg ggtgacggaa 2922181 atcatgtgct ggattctgat caaacaaaca gaatttcggg ctccttcaat tgtgatatgg 2922241 tcaggtttta catcgatcag tctgcctctg accgtatctc gtactgtctg tataacgaac 2922301 cttgagccga tgagcttttt aatggtctga tagacataag gatcgactaa agagaccagt 2922361 tgcggactac cttggttgac catactttta tcccctttgt gtgttttatc tcagcttatg 2922421 ccgcgcttat ggataatgac acaggcttac ctgataaaac aaaggggtgc ggagatttta 2922481 ggagaatacg tttggaggcg ggtgtaaagg aagtatcgat gaagcggaga cagcgaagaa 2922541 agctggcgct gttccgtact tatacaggct ttatcacgga tgcctgggct tggtcgatta 2922601 attggtccag cttttctatt ttttttcgtg cggttgaagg atcaatttgg cggtaatgat 2922661 ggtggccgcc cggctcttca tccagttcgt ccgctttttt gacaatctgc tgcagtgtgt 2922721 ttttatctaa ttcgccttca ggcaaatagg aatctgtatg aagcaaaatg gctagtgcaa 2922781 tctcttttgc tgctttcggt tcctcgccaa gccgaatcag aagtttatgc gcccgttccg 2922841 cccctttaat ggcatgaatg tcatttcttt tgtatttctc ataatcccac tttccgtctg 2922901 tataccattc ataatggcca atgtcatgaa gcagtgccgc ttttgctgct aaatcaggat 2922961 taatgtcagc cttcacagac agcctgtatg catgataagc gcaggcaatc gcatgtgcca 2923021 cgccggaacg ctgaagatat ttttgtgcaa ttggatgggt gaaaacatcc attaatgtaa 2923081 cctttctcat ggaaacccct cctttagata tttttagaat cctaacataa tttgcagaga 2923141 aactcaattc ttatgtcaca tcattttgat cttcttatca tcattgttat accctaaaag 2923201 caacgtttca gtcagtatat gcggctgttc aataaaatgc gctggctgca gccttttgta 2923261 taaaaaaaag agcagaaaat atctgctcta caaaaactct ttaatatcat aaatgcggcc 2923321 gttttccgtc cctttttcta gtaaagaaag cagcgtgccg gcaataaagt ccggactgcg 2923381 aaggcttcct gtttcattta atttccggaa tcgttcaatg tggtggaaat cctttttcga 2923441 tgaagaacgg atgacggcct gcatctcagt gtccatcact ccaggtgaga acgaaatcat 2923501 gttcaccggc agctcttcat cctcctgttc aaatccgaat gtcctcgtaa acatgtcgag 2923561 cccggctttt gaactgcaat acgcgctcca tcccttatat ggatttttgg cggctcctga 2923621 agtaatgttg acaaccgtct ttttgccgct gtatgaagca aaccgttttg taaacagctg 2923681 actcaaaagc acgggcgcag tcaggttcag ctgataatgg cgctgaagct cgtcaagaga 2923741 cgcttcgccg gcacgtttga tcggcgttac cattccggcg ttattaataa gggtaatacc 2923801 agaataacga tctgaatcga tggatgagag caatgtttca aattgctgtt cagcttcttc 2923861 gagattgatg aggtctattt gatgctgcgt tagttttttg tgagagacat ctgttttcgt 2923921 tctggataag gcatggactt catgcccctt ttctaaagcc tgtaatgcaa tggcttgacc 2923981 cagccctttt gacgctccgg tgatgatata aagttccatt ggaaacctcc ttttccgtta 2924041 ttattgtacg gcacctcttt tacacaacac aagcacgcgg cctacgcctt cttgttttcc 2924101 tgcgctgtga cttttgggat gaggaacacg atgcctgcaa ttccgagcag gatcagtacg 2924161 acatagatca tcggcagcag caatgatgat gtttcttgtt catcttctgt ttccgttgat 2924221 gatgtctttg tcattggttt ttcagcaaaa gtaattccaa gctgtttcga ctgggccgca 2924281 atcgtgttgg aatcctcggc atttgttgat gtaaacaaat cttttatcag ctcggcgtcc 2924341 ttgtccttcg gtttatcaaa agtgatatcc ttttgttcct caggcagttc tgttttttct 2924401 tcatagtagg tatcttcatg caaataattc gtatcgattt cgatgtcttt tttctcatac 2924461 tggtttggcg cgacatctgt attttcttca gtttgggcag ccgctgcaga gggtatgaaa 2924521 agggaaaagg agagcataca aatcatgatc cccttttcca tgctgcgatc acgcttcata 2924581 cgtttcatcg ctttctgctg tgtgttcagc catcaaccgg ataatcagcg gcagagccac 2924641 ggcaatcacc gtaatgatca gcagaactgt tattcccatt gtaaacaagt gcccagtacc 2924701 gtactggatg tcgatatata ctttcgaaac cggatcttca aatgtaaagt tcggcatgat 2924761 caaatcaata agcggtgcga catagaatag gatcattgct gctgaagcaa cccagccagg 2924821 gattgatccg aatctgaatg ccgtccggat gaaggcagag cttgcgacca gcaatagaat 2924881 cgtaaacacc gaccacttaa tcgtctgatc gtccggcagt gaataaatat tcaagccgaa 2924941 caagctgatc ataagtccga caaggatatt cagaattccg aataacgctc ctttgacgag 2925001 aagcggtgcg ttttggtaat acgagctgaa atagccgatt aacagactgc tgatcaacac 2925061 aatgacaagg atgacaaccg gaggtaccgt ctgaattttt tcttccggaa cctctccgct 2925121 gattttaagc ggattcgcta agtaatcata tacatagcca ttgttttgcc cgtctactaa 2925181 tgtatttccg agtatgccgt atacgtcatt tcgcacgagt ttcgtggagg cgacattttt 2925241 cccccagttg ttgtttaagg tgtcggcttt cgcttgaaca tcattaacgc tttgctgcat 2925301 gttggttgtg taatcaatga tgccggactg gcgatcagac aatgaaccca tcatgtctga 2925361 catttgcagc acttcctggc cgaccgtatc ttggacactc agtgccatgg taccagacag 2925421 cccatcgttg ctgaacgtcg cagattcctg tgttgcgccc gttacaagct gttctgacgc 2925481 ttttgcggca ctttcagaga ttttcgtcag ttcgtcgaga acacctgctt gagagtcacg 2925541 gatatagccg ctgtagtcgt ccgcaaattt ggtcatgccg tcgatgaagc tgttaatatc 2925601 ctcatctgtt tgcatcgtgt tgtttttgag agcttcccag ctggctgatt cttcaggtgt 2925661 gagagccagg actgattgga cgttgccatc ttgctcttgg atgacttcac ctttaataat 2925721 agtcaaagag cctagatcca gattatcatt tagcgtagac ttatataaat ttaaagagtt 2925781 gtaatacttc atcaagttag aaatattatc agtttcaatt ctacttgaaa aaattgaact 2925841 tagtttttct ttctgatcta tatagcctct actctgcaaa gtttgtatta tttcgtcttc 2925901 caaattgtat attaacctat aagcatcatt gacattatta tcaaaatcaa ccaacttttt 2925961 tgttaagtca ccaatttgat catttaattt tgaaactgtt ttatttaact ctttaatttc 2926021 ttgatttaac tcatcaatat gtttctctag tttgttgtta tgttcctctt gtttttcttg 2926081 aagtgcattt tctatttcct ctaattttat cgctgcttcg ttcagacgtt tttttgcacc 2926141 tgaaatatca gtttcaccgt cagctccgtc accctgtagc ccatcacttt gatttgagcc 2926201 atcgttttca tctgcgagtt caatcaaaga gaaatctgtt ttagaggttc ctgtattctc 2926261 cgtgtttgta tcttgttcag gaacgttttt tgaagattct tgatgttttt gtcccgtttc 2926321 aatgttagtt tgaacatcat tttgtgatcc attatcttga gtaccctctt ctgatgagcc 2926381 agtatcttca tttgttggct gatcatcgga tgttggaata tcattcgacg gttcttcagt 2926441 attaggagaa tcatcggttg atggttcttc agcatcgggt gttgttggtt tttcttgttc 2926501 aggttctttt aacccttcag agatatcttt aatttcagtt gcaacatttt tgagctcatc 2926561 ccgctgcttc tctaaatcca attttatatc ttcaatatct tccttatctg tgtcatcttt 2926621 attatcagat gtgtcttctc catcttcctt ttcgtcgctt tccttaggtt taagtaaact 2926681 aaggcggttc ttcccgatat tctcttgcaa ttgatttaaa ttttgatatt taatagcttc 2926741 atattgactt ttatatcgag atagaaatgc attaaacatg tcattctcaa tttttttcat 2926801 acccatttct tgcaatggca cttgattttg ccttaacttt tcagcattgt tcaacgcaag 2926861 gtttgtcagt cctatttgtg tcttcgcttg gccgatcccg gttgccaatc cgctcatgcg 2926921 ttcgctgaac tgattcgcct tttgctgtgc ctggatggca tccagacctg tccggatttg 2926981 ctgctgtgtt gaatcctggg ctgccaaaag cagctttttc tgattctctt gatattcttt 2927041 gtacctttca actgtatcaa tgaattcttt cagcgtgttt ttggcttcct ccgccgtaga 2927101 agctttttct tttgtcgtgc cttgcgcttc attcattgat ttcttcagct catcgattaa 2927161 gtctttttgc tgtttgattt cacctgctaa atcattagag cttggtttgt aaaagttgta 2927221 catgacattc tggaattcag attctttatt gacgatcttg tcaaattctc ctctgatgtt 2927281 gtccactttt tgcgaaacaa aattccagta taaggccgac atttttttgt tcattgtctt 2927341 ttgggcatcc tcaagctcac gctgaacttt ttctttgtta accgcattca ggttatcttg 2927401 aatgctgaat tcgagcgttg ccttttgagg atggtctttg tcatagctca aaatgttttt 2927461 tgagaagtct gagggaatgt agacaatcgc atcgtatttc tttgaagcga gaccggtctc 2927521 ggccgcgctt cggtttacga ccgtccacga ataatcagga cgttcaccca gaacggccgc 2927581 tacttccttg ccgaactggg cggatttgtc ctcttcatca gactttacct catcactcaa 2927641 tacgcctgtg tcttcattca ccaccgcgat ttgccgggta gaattgactg cttttttcgt 2927701 tgggtcgtct ccgataaatc ggaaaaacaa caccggcagc agcaaaatga tgatgacggc 2927761 ggatattaac ttgatcaagc tttttcgttg ttctgtcatc tagcactctc cctttcagca 2927821 gaacataaag gaatttgaac tttttgctcc ttcccgtttt ccacaacata tccgaagccc 2927881 ggctgaatct caggctcctg tctttggtac gggagaggaa tgacattttg ctcagacttt 2927941 ttcatcagca gaatcgcgtg gcggatttgc ttcatctcag tcgtcaagga gtcatagcct 2928001 tttgagaatt cgctgtggtt tccgcccggg ataaagctga acccaagatg agcgtatgat 2928061 ttcatgaagt tagcgagacg atcttgtatt ctcgtatcaa tcgtctgctg gaatctcgtt 2928121 atcccgtcaa tcatcagcac gacttgtgag aatcgcagat tttgtgcgtc tccttggcgg 2928181 acggcttcta catacatggc ttctcttgtt ttgaaaatgt cttctgctgt ttcaatccac 2928241 tgctcaatat cttctttcgt ttccaaatat gaaacatctg attccttcgc ataatgagat 2928301 aagccgcggt caatcgagtc aaacaggccg atcatttcgg tttcatcatc aatcagatgt 2928361 tcaagcatga cttttaggac gtttgttttc ccgcgctgag tttggcctaa aatcaggcag 2928421 tgcttatgct tgcccaaatc aaaatagact gggctgactg tttcttcatg aagcccgatc 2928481 ggtacagata aaggcttgcg ttccagcttg aagcggatag acaattctct cgtcgacaag 2928541 ctctcaggca gcatcggaat cggtgccggc tgctccattg aagcaaatcg cccttgaagt 2928601 ttctgtacgt ctgatttcag ctcgttgaac atgccgatat catcatcggc gtcaacaggc 2928661 aggaacattt gcgcgaaata aagctcttcc ttttgaatga tgacgcgtcc cggaatcggc 2928721 tcaagattga atttcggacg gccgtaaatg gaatatcctt ctgattgatc catgagataa 2928781 tggacaatct ttgttttcaa gttatttaac aatgactggc ggacagcatt cacccgcgtt 2928841 gctgtcagca taaagtagat acccaagctt tgtccgtctc tggaaagctg gacaaattcc 2928901 gattcaagct catgcatctc atccttgaca atgtcaaagt tgtcaatggt gataaaaatg 2928961 aatggaagct cttcttcgct cagcgcattg tacattttga tgtggctgat ttctttttcc 2929021 cggaacaaac gtttacggcg gtcaatttct tctttgatgc gaatcatgaa cttttcaatt 2929081 ttccttgact ggtccatcag gaagtaatcc gcggtatgcg ggagcttcgc taatggcagc 2929141 agcgttccgt ttccgaaatc aaagatatag acatgaagct cttcaggtgt gtatacgtcc 2929201 gcaaaactca tcaggaacgt tgcggctgca atcgattttc cgtagcccga agagccgaag 2929261 atgccgatat ttccatcttc catcatctta taagcaattg gcgcctgtct ttgcagatca 2929321 ggttcatcga catacgcaaa gtggaaatgg tctttttcgt ttgaagggaa aagagtgcgc 2929381 ggaatacgtt ccgcaagcgg cggcagccaa gggcttggca gcttctcgat tcccatttca 2929441 tcttggatgc gttcaatttc gtcaactaca gcttcgattt cggtttgaac gtcttttttc 2929501 gcgttatctt cggtatcaac ctcagaaagc gggatcagac ccgtatctgt gacgatcgcg 2929561 atttcatcct cggtaccgta gacttcctct aagtaaggcg ccccgctcca tgcagattgg 2929621 aacagctcat acacttcatt gtttccgacc tgcaaatagc cgcggcctgt tacggtaatg 2929681 tttgcggcat cgctgttttt caaaatttct ttactgtcgg tggcatcctg gaccttgagc 2929741 gctactttaa agcgcgagtt actccagatc tggtcgtcga tgatgccgcc tggcttctgt 2929801 gtcgccaaaa tcaaatgaac gccgaggctt cgtccgatac gcgcggcact gacaagctcc 2929861 ctgataaaat caggctcctc gcttttcagc tcggcaaact catcagaaat taagaacaag 2929921 tgaggcatcg ccacttctgc tttcccttgc ttgtatagct ttgtatagtc attgatgtga 2929981 ttgacttgat actggtcaaa caggcgctgc ctttttttta gctcgctttt aatggaagca 2930041 agcgcacgca tactgaagtt tttgcttcct tcaatatttg tgatcgtgcc gaggaggtgg 2930101 ggaatgttac ggaacggctg cgccattcct ccgcctttat agtcaattag taagaaagcc 2930161 gcttcatgcg gatgaaaatg cactgcaagt gacaagatgt aggtctggag aaattcactt 2930221 ttccctgatc ccgttgtccc cgcaagcaag ccgtgcggac cgtgtgcttt ttcgtgaagg 2930281 ttcagataca caatgtcatc tttcccttta tagccgatcg gcactgacag cgacttcgac 2930341 gattcacttg tcagccatct ttgctgaatg ccgatttctt ttacttcctt cgcatgaaaa 2930401 agctccagga acgataccgt ttccggaatg gaattcgtaa tgccgacctg gtggttcagc 2930461 gtccgcagtg tgcgtgaaaa ccgttcgtta tcctcacgct gatgatgatc gagacggaac 2930521 ggaattctta ccgctttttt cttttgtatt aaaatgtcgc cttcatgctc attaatgtag 2930581 cggacaagag ttgtaatgtt ttccgacaag ctttcctttg tttctgcagc gacaattgtc 2930641 gagatgccca gatgctcatg ctgcccttct aaatattcga gaatgacatg ctcagagatc 2930701 agctgctgat tcgtgatgac aaatacaaaa tgcggtttga actgcagttt ttctttgtca 2930761 tcttcgagat cacgctctct gatcaattcg taaagtgaag acaggagctg atctcgggtt 2930821 tgctcattat aaataaatcc ttttgcataa atatggggca tttgaaattg cggaagccac 2930881 ttcatccact cccagtcttt atactcttct tcatgaaaaa taaatacgaa acgcaaatcg 2930941 tgatagctgt taaagaacga cagctgtccg attagctggt gaatctcatt tttcacaatt 2931001 tgtgatttac cgacaagccc catcggacct tctgccaaat cgaccgtcac cggcgcatta 2931061 cggatatctt tatagacgcg ttgcatgtgc tgcgatttct ccatgaggtc atcgatatca 2931121 cgattcgcca agtctccgcc actcatattg atttcatagc ttgacggaac tgttcccgtc 2931181 ccaagccgca gctggagata atccttgctt tcaagtgatt tttcccagat ccggtcactg 2931241 atttcacttg ttaagtattt catttgttca aatgaaggaa agtgaaattc aagaacctgc 2931301 ttttgctttt cagcaagtgc ctgaagctct ttccgcttat tgtctaagta aagcttatat 2931361 acacgctccc gtttttcctc gcgttttttc cgctggtttt tatcacggaa atattgcact 2931421 gtcgaggtaa tgagagtcat cataaacatc gccaaagaaa cgagtataaa tatgccgcgc 2931481 ggctggatga tggcaactac gcccatcacg atcagcatca caagcggagg caggatgacg 2931541 agccacagcc ctctgttggt ttgatcgctc tcctgagagg gaaaactgaa agaaacgcgg 2931601 tcatccggca gatcgtatac catccgcggc gttcttctgt actgcggata ttttttctgc 2931661 atctctgtac tcggtttgac cgtttctgtt aacgctgttt caaactgggc ataatgaaca 2931721 atttctaaaa ggtcttgttc cgtcaccctc atttgcgtga agttccagaa tatttcatcc 2931781 cccggcttga gcggcgtatt ggcgttgatt ttctctccgt tcaagaagat cgttccgctt 2931841 tcagggcgga ccgaccagct gccgcctgca cggagcaaag aaaacgtgct ttgttctgca 2931901 aatgcaaaat cttgcggatt cagataaata tctgcattcg ttttttctga ggaacataca 2931961 atttcatccc gatttcccgt aaaataaacg gatttctcag gttcactgcc cgtcaatatc 2932021 aagcgtatat cctgctgatc cgtttggaga gtaaatgata tatccgtctc aatcgtgccg 2932081 agacaatcat ttcccaggaa aacttcgtat tggccgccgg attcctttct tttaagagaa 2932141 atcactccgc tattaaatgg aatggtgctg atcgtaacag aatccttcac atcaggccct 2932201 atggtcaccg gatgagacga cgggaggtta gacagattta atttttgaac gttattttgg 2932261 taaaaaaccc ataatagact caaatggcga acccccttac ggccgaatgg cagcatgcga 2932321 tgacctgcgc ttcatgtctc acgttatttg tcatcttttt tctcatcttt cttttctgtt 2932381 tcttttttct cgtcttcttt ttccttctgt tcttcttttt tcgctttttc ctcggctgcg 2932441 gctttttctt ctgccgcttt ctcttctgct tgtttttctt cgtctgtttg tgtctgttct 2932501 tcgcttgtat cgactaacga tgtttcagaa ttagactgtt tattttcttg acgttctttt 2932561 tgggcttttt caagctcact atttactgaa tcaagttctt tttgtatgtc ttcatcattt 2932621 gtatcctcag ataaaagctg ctgtttatat ttagctaggg caaagtaaat ataatcattg 2932681 tattccagct tacggccgat actgatcgct tctttgtatt ctcctcgacc ataatcaatc 2932741 caatataaga aatgctgagg gtctgattga agggtgacta aattattttc tatatttttg 2932801 gtttttgcac tccccaggtt ttcgacctca acataggacg tcgccagctg atactgcacc 2932861 gattcaggca ggctttccgc atcgtacttg gacagtgtgc tgatgacttc actgtactgc 2932921 ttgtttaaga acgcacggtt gctgtccact atcgcctggt gctttggctg cgcgaaaaat 2932981 aaggcgtaca tcgaataaat aagtgccggt acaagcaaaa caatgagccc caggccgata 2933041 tatcgctgga tgttccactt ctttctcggg atatgtatgt atgtttttgc tttggcttcg 2933101 agctcatcaa tatgggtttg aatcagctcg agcaaatcat cataggattc agcatctaat 2933161 atcgcctttg cctctgcgga gaacgtcagc gtttcattga atttcaggta gtcttcaaac 2933221 gcaaaagcgc cgtcaactgc caaagccgct gccgctttca gctcctgcca tactctttcc 2933281 tcatcacgct cgtaaggagg aatgctttct tttactccat aatggagaaa ataaggcgta 2933341 agccctttat cgaatacaat gttttcagga gcgacaatca aattcagcct cgacagattg 2933401 tgctgctgta cggcttgaac aagctgatag gcaaactgcc atttactttt tttatcctta 2933461 gctttcatga agcggaatgc tttataggag gagggaggtt ggattgtgat gattacttca 2933521 tcatccgtca catcgatttc tttatgaaaa aatggattta tatctttgat cacgttagct 2933581 tcaagaccgt cgagaagctt tattttttcc cgttgaaagg taaatgtata gccggcatct 2933641 gttttctcgg caacagcttc taattggttt tctaaatatg atttttgttc acctgacatt 2933701 caaccagatc ctttcataat atttcaagcc ggtctccgtt tgtaatgccg caatcagaca 2933761 gcttgcattc tccggaaaac accttatcct tgttcaccac tctgatccag tgcccttcgc 2933821 gcggaggcat agatacgctt tgggcctgcc aagcaatatc aattactttt ttcaccgggt 2933881 ggtaatctga caatctgaga tcaaagacac tgccgttata atgtttcaaa tctattgtaa 2933941 tatcaatata catttaggat cacccttaca tagaaagagc gccgtcttct tttgaatcag 2934001 gcgctccttc cctttcatac tgttatccgc ggatttgatt tgcgatgtct tggtcagtag 2934061 actcaagtgt atttgctgtt tgatcaagct gctgattcac atcttgaagc aaatctgaca 2934121 ttttgataaa tgaaggtttg agctgctcgt attgatctgc gaacgcttcg cttgaagcac 2934181 cttcccacat gcttttcaaa tcagagatca ttcggtttaa acgatcaacc tgatttaata 2934241 cttcttggct ttcaacgccg tattgcttcg ccatcgctct tagctcttcg ggtgtgacac 2934301 gaattaatcc tgccatattc ctcattacct cctgtgccat cagcctaaat atgggctaat 2934361 tcacttattt ttagaacgtc attattataa aaacagtttt tcggcatagt caaacaaata 2934421 tgttttaatt ttacaaaatg agtccaatgg tttaccccga atcactcaaa aatgacatat 2934481 actgtaaagt aaataggttt attttcttaa tcttctcttc attctccgaa taatccaaaa 2934541 gacccaaata actctccaac tcccaaaaaa aacctttcag aaaatttgat gctacagcac 2934601 catttctgaa aggttcagtt ttttctttcc ttaattagtc ttgcctccga tgactttctt 2934661 agaagattaa taggataagc tgtcgtatta tatgagacat acactgtcct gcaaaaaggc 2934721 gattacaccg ccaaatgtat atagaacgtt tctctcatga aattgttttt ttgcttctgt 2934781 tctttgttgt tgattttcac aaacaacaac aatcataata aaaggaaggg gatgagatgt 2934841 caaagagaaa tcaagcacga aaagtaggga gatttatgac catgccgaat gatccgttta 2934901 aatatagttt tgacagactt gaagatgtgg ctgatcatat cagcgacgtt ctgcggtgcc 2934961 cgatcaccat agaggatgtt aaccacaagc tgcttgccta cagtacacac agcgactgca 2935021 cagaccctgc ccggacgtct accattattg gcagaagggt accggagaag gtgattaaca 2935081 agctgtggaa agacgggaca attcctgctc tcttaaaaac ggaccagccg atcagagtca 2935141 agcaaatcga tgaagtcggg ctgagcaatc gcgtcgctat ttcgatttgg aaaaacaagc 2935201 aagtacttgg cttcatatgg gcgcttgaga tccaaaaaac attgtccgat gaagatctgc 2935261 tgacattgca aatggcagca aaagcagtga aaaacaagct tctcaaactt caaatcagaa 2935321 aaacgaaaaa tgaagaacgc agccaagaat ttttctggaa aatgctgacc ggacacatcc 2935381 atcaggagga tgatatggcg gatgggttcc ataagcttgg aatggccgct ccttcagagt 2935441 tttccgttat gatcatccgc ataaatggcg agctgactga aaaaatcgaa cagcagctgc 2935501 aatatttaca ggaaacgacc cagcaggttt acgtgctgct ggcgaccgta gattccaatg 2935561 aacttattat attaacctca cccaaaacag atcatccttt tcaagattta aaacagtttg 2935621 ctttaagtac gcaaaaacag ctgaaggagc ggtataaaat agaagacgtt tctatcgctt 2935681 ttggcggaat atacaactct atttcttttg tctcccgctc ctatcaggaa gcattgtccg 2935741 tcttaaaaac gaaggaacgg ttcgctgaag agaccaaaca tcttttcagc ttttctgagt 2935801 taggcattta tcaatactta gatgtcttaa atgaaaaacg gaaacaggcg ggccattata 2935861 attactcgct ttccaaactg gaacaatatg accgggatca ccagtcaaat atggtagaga 2935921 cgctagagcg ctttattgaa gcggacagca acgtgaatac cgcttccaag ctgttaaata 2935981 tacacgttaa tacgttgaat taccgactca agcggatcag ccagatcgct gaaattgatt 2936041 tgaaaaatgt gaatcaaaaa ttcaccatct atttagatat caaacttcgg cacatggatt 2936101 tgtgaaattt cacaaatcca tgttttttta ttttcttaat caaacaaaga attttccaaa 2936161 atatcaagct acactaaaaa tatcacatat acaggaggag acagatatga tcataggggt 2936221 tcctaaagag ataaaaaaca atgaaaaccg tgtcgcatta acacccgggg gcgtttctca 2936281 gctcatttca aacggccacc gggtgctggt tgaaacaggc gcgggccttg gaagcggatt 2936341 tgaaaatgaa gcctatgagt cagcaggagc ggaaatcatt gctgatccga agcaggtctg 2936401 ggacgccgaa atggtcatga aagtaaaaga accgctgccg gaagaatatg tttattttcg 2936461 caaaggactt gtgctgttta cgtaccttca tttagcagct gagcctgagc ttgcacaggc 2936521 cttgaaggat aaaggagtaa ctgccatcgc atatgaaacg gtcagtgaag gccggacatt 2936581 gcctcttctg acgccaatgt cagaggttgc gggcagaatg gcagcgcaaa tcggcgctca 2936641 attcttagaa aagcctaaag gcggaaaagg cattctgctt gccggggtgc ctggcgtttc 2936701 ccgcggaaaa gtaacaatta tcggaggagg cgttgtcggg acaaacgcgg cgaaaatggc 2936761 tgtcggcctc ggtgcagatg tgacgatcat tgacttaaac gcagaccgct tgcgccagct 2936821 tgatgacatc ttcggccatc agattaaaac gttaatttct aatccggtca atattgctga 2936881 tgctgtggcg gaagcggatc tcctcatttg cgcggtatta attccgggtg ctaaagctcc 2936941 gactcttgtc actgaggaaa tggtaaaaca aatgaaaccc ggttcagtta ttgttgatgt 2937001 agcgatcgac caaggcggca tcgtcgaaac tgtcgaccat atcacaacac atgatcagcc 2937061 aacatatgaa aaacacgggg ttgtgcatta tgctgtagcg aacatgccag gcgcagtccc 2937121 tcgtacatca acaatcgccc tgactaacgt tactgttcca tacgcgctgc aaatcgcgaa 2937181 caaaggggca gtaaaagcgc tcgcagacaa tacggcactg agagcgggtt taaacaccgc 2937241 aaacggacac gtgacctatg aagctgtagc aagagatcta ggctatgagt atgttcctgc 2937301 cgagaaagct ttacaggatg aatcatctgt ggcgggtgct taattcacaa taagcttgca 2937361 gaaagatttc tgcaggcttt tttatttttt aaaaggaaaa aagagaccat ttcacgaatt 2937421 atgactatga agttgatcat aaaggaggat tcatatggct gttcagcaat atggcgtgtt 2937481 aaaaggcata gtattagaca tgaagcggga aacagatgat gacagtcctc atttccaagt 2937541 caaaatgctc ggtgaagaga atacgtatta caggtgcgcc atcaatgtga tgtccagttc 2937601 tgaggaatct gaagtattgt atttggctga cgatcagttt gattcgggct caattaccat 2937661 ccttccgaac atgccgtatg gatatacaag gatcaatgaa gcaaaccgtg aagtggcact 2937721 ggattatgtg cggggcaatt tgtttgaccc gcgggaaatg aagcctttgc ctcatgaaat 2937781 cacgggacct gataatgatt taaatgattt tattgaaacc tatatgaaga aagcacaaga 2937841 tgagaaaacg ccggtttata tattcggttc aaaattcggc cctgaacagg ctgcagataa 2937901 aatattcggc tttaccccga ctaacggaat gcacaatatc catatgaatc aagggaatgc 2937961 aatggatacc cgctggaaaa aagacaacgg ctcttggcat gacgggggta ttctgattca 2938021 gtttgcagat cagtgggccg ctgtgttttt agcgttttta tcccaatctt ggtgtaccga 2938081 tgaaaacgga aaccctgtca gagattgtga tcatacccaa acgtctgcgt aagatagaaa 2938141 aagagactgc ggcaagcagt ctctttttga taagattaca cattttcaac agtctttagg 2938201 ctgtttggcc tcatatcgct ccaatgcgat tggatatagt ccaaacaagc ttcacgccct 2938261 ttttgctcat gaacgactgt ccagccgctc ggcacatcta taaaacccgg ccatagggaa 2938321 tattggcctt cttcattgac cagcaccaaa tatgtgccat ccgcattttc aaaaggattt 2938381 gccattctat ttctcctccc ttatttattc aactcttcca atttgacagc gagaaccttg 2938441 ccgatttgag ccagaggttc aggctgacat aaatctttat gacggcagtc gatgtcgatt 2938501 tgttcaatct gtccgttaat ataaggcttc cacgagtcag gttcaatcgg gtcaaaccat 2938561 tcaggaatga ttgttgatct gaaaaacaaa acatttccgc ggaaggtttt cggcttatag 2938621 gaacctaaaa tgccgacaga atttacatac gtattcttca aatttaaaat gaccgtttca 2938681 tccaggctcg caagcgcact gccgtcacgg cgaagaatct caatcgccgc ttcaaaatct 2938741 agcggttttt cccctaagct gtctggatca tacccgccta acgccagaag ggcaataagc 2938801 gcttcctcat catccggtgc ctcttttata ggaaggaagt ggttcggata ggcgtccagc 2938861 atcaccaaca gggatacttc ttctccttga ttttgcagct gggtagccat cgcttgaacg 2938921 acattcccgc ccagggacca gcccagcaga tggtacgggc cttttggctg gaccgttcgg 2938981 atttgtttaa tgtaatcggc agccatgtca tcaagtgttt tcggaagctc ctcgcgctgc 2939041 ccgattcccc gtgcctgcaa gccgtagatc ggataatctg ttcctatatt ggtcatcaaa 2939101 ccggcataac accagctgag cccccctgcc ggatgaacac agaataaagg aggcttgtct 2939161 ccgcttgttc ggagcggcag cagaacgtca agagcgcttt ggcttgatcc catttcaagt 2939221 ctttcagcga gcccggctac agtaggtgct tcgaacaagt tgccgatgct gagttcaacg 2939281 ccgagcgctt cacgaatgcg gctcatgagc tgtacagcaa gcaaggaatg tccgcctaaa 2939341 tcaaagaaac ggtcatcaat gccgacacgc ggcaagtgaa gcacctccat aaagaggtca 2939401 cagagaattt cttcctgcgg cgttctcggt cctcgtcctg tcactgccgc tgcgaaatcc 2939461 ggagcgggca gcgctttacg atcaagcttt ccattcggtg tcagcggcaa ttctttcatc 2939521 gtcacaaagg cagcaggcac catgtaatcc ggcagtctct cagcagcata tctgcgcagt 2939581 tccgccgtat caaatgtttc ttccgaaggg atgacataag ctgctaaccg tttatctccc 2939641 ggctgatcct cacgaacgat cactgccgca tcttcaagct gcggatgctg aacaagcgcg 2939701 gcttcaattt ctcccaattc aatccggaat ccccgaattt tcacttgatg gtctgcacgg 2939761 ccgacatagt cgagagaacc gtcagcgcgg aggcgggcca catccccagt gcggtacatc 2939821 cgggtgcctg gaggaccgaa cggatcagct atgaagcgtt cagatgttaa accaggccgg 2939881 cctagataac ctcgtgctaa ccccgctcct gatacataca gctctccggc aacacccggc 2939941 gggaccggct gcaggcgttc atccagcacg tatacaccaa gatcgggaat gccgcagccg 2940001 atcaagctgt ttgcccgtaa agctgccatg cttcggtcta attcgatata gctcacatgc 2940061 accgtcgttt ctgtaatacc atacatattg ataagctgcg gtctattttc agggtggcgg 2940121 ttgtaccaat cctctaaacg gctgagttca agcgcttctc cgccaaaaat gacatagcgc 2940181 agactgagtg cctgtccgag atccggctgt tcccgttccg cctgcataaa ctgatagaaa 2940241 gcagacggtg tctggttcag aacagtcacc ccctctttga caagcaggcg cagaaacgct 2940301 tctggcgatc tgctgacgtg gtgaggcacg attacaagac gtccgccatg cagcagagga 2940361 ccccagatct cccacaccga aaaatcaaac gcataggaat ggaacatggt ccagatatca 2940421 cctgagctga aacggaacca gtgctcggtc gctgcaaata aacgtgttac attttggtga 2940481 ggaatcatca caccttttgg aacacctgtt gagccggatg tataaatgac atatgccgta 2940541 ttcaaagggg aaagcggctg agtcctatcc ttattttttg gattacctgc agggtacgtg 2940601 tttagtttct ctgccagctc gggatcatcc agcacgattt tcggcacgtt ttcaactggc 2940661 ggaatgtgat ttgcagcttt agtgttcgtc atgataaacg caggctgtgc atcttttagc 2940721 ataaaagcaa ttcgatcagc cggataatcc ggatcaagag ggagataagc tgccccggcc 2940781 tttagcaccg ccaataggcc gacagccatt tccaacgatc ggggcagtgc caatgccaca 2940841 aattgctccg gcccgacacc ttcactaatc atcattcggg caagccggtt tgctctttca 2940901 ttcagctctg catagctcag ttcctgattt tcatatacaa cggcaatggc atcaggacgt 2940961 aaagcagcct gcttctcaaa ttgctctggc aaacatgcgt gcggaatctt ttcagataca 2941021 ctttgccaat cagtcaccat gctgctgtgt tcctctggcg caagaatatc cagatttccg 2941081 atttgctcgt caggatcaga ctcggcagcc tccaacaggc gcatcaatcg gtcagcaaga 2941141 gcctgagcag tttcccgttt gaaaagatca gtgctgtatt caagcagtcc ttccattccg 2941201 tttggtgtcc cgtcagcaag gcgatcttca ctaatttcca gcgtcaaatc aaacttggca 2941261 gaaccgacac tgttgattcg caggctgctc tccatatcag gaagatgcag ttcagcgtcc 2941321 ggtgtgtttt ggaacgcaag catgatttgg aataaaggat gcgtcgcacg cgaacgagcc 2941381 ggattgagca cctctacaag tctctcaaac ggcagatcct gattgtcata ggcggccaga 2941441 ttcacttccc gtactctgtc tagaagctca cgaaagcttg ggtcaccgga cgtatcagtt 2941501 ctgagcacca atgtattaat gaacagccct acaagatcgc ccagcgcatc atcattccgt 2941561 cccgcgatcg gactgccgat cggaatgtcg gtgcccgccc cgagccttgt caataaagcg 2941621 gcgagaccgg attgaagcac cataaacagg ctcaccctat ttgcgcgagc cagctcctgc 2941681 aatcgcttgt gaaactcggg ctcaatacga aaatgaatcg tatctccatc atgactcggc 2941741 tcagccggac gtgaataatc ggttggcagt tcaagctgat caggcaggtt tttcaaggtt 2941801 tctttccaga aagcaagctg tccggcaatc aagctatttg gatcatcctc gtttccaagc 2941861 agttcttgct gccaaagcgc atagtctgca tactgcacag caagaggcgc ccattcggga 2941921 gatcgtccgt ggcagcgagc cgcataagct gtcccaaggt ctctggtcag cggtgttaag 2941981 gaccagccgt ccccgacaat atgatggacg agaagaagca gcacgtactc gtcaggaccg 2942041 atcacaaaaa gctcggcacg aaaagcaggt tcagctgcaa gatcaaagct gtagcgtaca 2942101 gcttcggcaa gccgatcaga aagctccttc tcagcaattt cagtaacatg taactcggga 2942161 caggctcgat cggcatctaa aatatgctga taggatgtcc cctgtgattc agggaagatc 2942221 gtccgaagac tttcatgacg gcagacgagg tcataaagtg ccgctttcag caatccttga 2942281 tccaactcac ctgacaaacg gacagcaacc ggaatattat aagtaggact cggtccttcc 2942341 agacaatgca ggaaccatag ccggcgctgg gcaaatgaga gcgggatctt ttcaggccgc 2942401 tcagctctct gcaaagcggg acatgcactc tgcgccaaat caagatgggc agcgagtccg 2942461 gctactgtcg gttcgtcaaa gagcttggcg ataccaagtt cggctcccat tacctcgcga 2942521 atgcggctca tcagacgggc tgcaagaaga gaatggcccc caagctcgaa gaaactgtca 2942581 tcgataccga cgcgtgccaa accgagaacc tctgcaaaca agtcacacaa tatctcttcc 2942641 tgaggagtcc gcggggcccg atcactgaca gatgtgctga agtctggtgc cggcagtgct 2942701 ttccggtcaa gcttgccatt aggtgttaac ggcagctcgt ccatctccac aaacgccgac 2942761 ggtaccatat aatcaggaag actagccccc atataacgac gaagctctgc agtatcaata 2942821 gcagcatcag cgactacata agccgccaat cgtttgtctc ccggctgatc ttcccgtacg 2942881 acaaccgcgg cctgttcaat gtgcgggtga ttggcaagca cggcatcaat ttctccaagt 2942941 tcaattcgga atccgcgaat tttgatttga tgatccgccc gcccgatata atccaaagac 2943001 ccatcggcgc gccagcgggc ctggtctccg gtccgataca tccgagttcc cggcggtccg 2943061 tatggatctg caacgaagcg ctccgccgtt aaatcaggac gatggaaata acctctggcc 2943121 aagccggttc ctgcaatata aagctctccg acaacgcccg gcggcaccgg ctgcaatcca 2943181 ttatcaagca catacacctg cgtgttccaa atcggtttcc caatcggagg aacgcccttc 2943241 agcccttctt caagaaaagc tgcggcagac caaatcgttg tttcagtggg accgtataag 2943301 ttcgtgactg aacaatgaag gtcttgaagt tcctgcaaaa gaccgctcgg cagcgcctcg 2943361 cctcctacaa gcactctaag cccccgaagt ttctcaggtt cactcgttac caaagcgtgc 2943421 cacagtgtcg gtgtcgcctg cataatgtta atatcgaaat tttcaatcat ttgagctaat 2943481 gcctgcggct cacggatcgt ttctttcttt gcgatcacga tttgcgctcc gctaatcagc 2943541 ggaagatata actccaatgc tgaaatatca aaagcgacag tcgtcacagc caacagcctg 2943601 tcttcttctc ctagagaaaa tgcctcctgc atagacagca gaaaattgct taagcttttc 2943661 tgtgtcacaa cgactccctt cggtcttcct gttgatcctg aggtatagat gatatacgca 2943721 ggatggtcaa gcgaaaccga tacatcctga ttttccggcg aatagcgttt tataatctcc 2943781 tgtgtaacag cctgatcaag cacaagctca ggtacagcca ggtcatcagg cagactggct 2943841 gctatttcct cagtcgttat gatgcatgaa ggtttcgcat cctccagcat gtaagaaatg 2943901 cggtcggctg gaaactccgg atcaaggggg agatacgccg caccagtctt gagcacacca 2943961 agcattgaag ccaccatctc aggggaacgc ggcagcgcca aagcgacaaa ttgctccgga 2944021 ccaatccctt tttcgatcaa cagacgcgcg aggcggtttg cctcttcatt gagctttcga 2944081 tagttgactt gaatgtcatc acacatgaga gcgatacgtt ctggcgtaag aactgcctgc 2944141 ttttcgaaca tgtcctgaag gctgaccagc ttctcggatt ttgccgtctc attccattta 2944201 gaaatgactt tttctttctc ctctggcaac agaagctcca tttgcccaat cagcatgtcc 2944261 tctccggcag aagccgtttg cagcagctgc aaaatacgct gctgatgaag cttaatatca 2944321 gactcactgt atacctcggg attcgcatca acatcaattc gcagcccgct gccgtctgtt 2944381 ctgtcatata cattgattga tagatcatca acaggaccgg ctgaaagatt atgcgttgtg 2944441 ccccggacgc cggcaaagtc gagaccgtaa tcaaacggca taagattgat ttgagggcca 2944501 aataatctat gattttctcc tatcaatttc agatcgcgcc taagctcttc atggcgatac 2944561 ttatgatgtc gccgaatact gcggatttcc cgggaaattt gctgaatcag ttcagaaaag 2944621 ctcatcgaag agcttaccgt cagccggagc gggagaaggt tcatcaccat agccggtaca 2944681 ttcagtgacg cggaccctat ccgacccatc atgggcaggc cgagcacaac atcctcagag 2944741 ccggtcatac ggtgcacata aacagctgac accgcaatca tgacttcatg ccagcttcct 2944801 gagaaatagc gcgccgcttc ttttaacgcg tttacatcag acggaggcag atatgccgta 2944861 tgacgaagaa aactgttaga tgttcttggc gcccgatcag ccaagctcac aacttcaggt 2944921 gcatctgcaa aacggtccag ccagaattga cgatccttct catactgctc tgatccgcga 2944981 taatctgtat cctcctccaa aatggcctgg agagacccaa aggaacggct tttagctgtt 2945041 tgtcctttta taagggcagt atatgtactt gccacacgct gggctatcag ggaaaaaccg 2945101 aagccgtcga tcgctatatg gtgaatgcgc tgataccaaa agaaacgatc aggcccggca 2945161 ataaacagag cttcattgaa caaaggggca taccctaaat caaccggctt tgctaaatca 2945221 gctttcatcc agtttaatgc tgttttttcc ggatcaggct cagagctgac gtcaatgacg 2945281 tgcagctgta catccggaga cgggtttatc atctgccaag gcccgtccat attttcaccg 2945341 aagcggacat gcagcgattc cgcttccttg atcacgtgcc gcaaagcttc ttcaaaaaga 2945401 gcaatattga ctggtccatt gatttctata tattccgctg tattgtagat tggattgtcc 2945461 ggatcaagct gctgagcaaa ccatatgcca gtttgcgccc cggtcaaaga atattgaaga 2945521 tcttttgtat caggcatccg tttgtttacc ctccttttat aaataatccg cgtttggcag 2945581 cacttgctgg ctgcgagttg tgagcaattt ctgccattct tcgatcgttg ggcgttcagc 2945641 caattccacg aaagtcacct ctgccccttc acggcgccat tgttccacca atgtcatgat 2945701 ccttaccgaa tcaagaccac gatcgagcaa atcctcttga tctgtgatgt cttccggtgt 2945761 ttcttgtaga agctcagcaa tttgtttacg gatattctca catgtaaaca cgttcttttt 2945821 gccagtgttt gctgacgttt tttgaacgtc tgccggcgca ttctgcagct gatcaagaag 2945881 actgtcagtc atcacggtaa acgcacagcg tccagccgca tattccagcg ccatttgatg 2945941 tttttctaat gaaaaatcag caactgcatc tcccacaaaa aaggctttaa tatcctccat 2946001 aaatgcttca catgctgtaa caagacagcc gatatgggcg taaattcctg taatgatcag 2946061 ctgatcgcgt ccctctttgc gcatcatttc aagcagattc gttctcttaa acgcgctgta 2946121 tctccatttt gtcagcacaa gatcatcatc ctctggtgcc agctcggtta taattttctc 2946181 ctcataagga ccgctgttta atcccgggcc ccaaaagtct gtcagcagcg cacggtcatc 2946241 cggattttgg cttcccggct gtgcggtata gacaacagga atcccaagct gaacacattg 2946301 attcttcagc tttcgtatat tcgctgaaag ctctgttacc ggagacgctc ccgctgtgaa 2946361 agcatcaaca aaatagtttt gcatatcgtg tattaacaag acagcccgat tcggatcagg 2946421 cacccatgat actttgtttt gcggcatatc agatgctgtc ggcatttgat acggctgaat 2946481 ggcaggtata gccatatgaa cacttcctct caaattgttg ttttattttt taaatcctgc 2946541 aagaagcttc tcggaaatgg cttcacggag cgcttttttg ctgacttttc ctactcctgt 2946601 ctgcgggaag gattcgacaa attcaactcg atcagggatt ttatatgccg ccagtccgcg 2946661 ctctctcaaa aatgctttaa gctctgcggc ttttggggct tcatcccggg gaataatgaa 2946721 cacacaagat ctttcgccaa gaaattgatc aggcatggag accattgccg catcatggac 2946781 agccggatgc gccagcagat gattttctac ctcttcagcc gcaacctttt ctcctccacg 2946841 gttaatttga tccttcgccc ggccttcaac gacaatatag ccgtctcgtg tcagcctgac 2946901 gatatcaccc gtacggtaaa aaccgtcctc agtaaatgaa gcggcgttat gctcttctgc 2946961 cttatagtaa cctcgaattg tatacggccc ccgcgtcagc agatggcctg tttcaccagg 2947021 ttttacgtcg cgatcatgat catcccaaac acgcatttca tcatatggag acatcggttt 2947081 tccttgggtg ttgacaatga tctcctcagg atcatccaat ctcgtataat tgacgagacc 2947141 ctctgccatt ccgaacacct gctgcagcgt gcagccgaaa acagctttta ccctgcgcgc 2947201 ggcttcagca ctaaacttgg caccgccgac ctgcagcact tgaaggctgg ataaatcatc 2947261 acggcgtgag gatgccgcat ccatccatac catcgcaaga ggcggaacaa gagcggttat 2947321 cgtgaccttt tcccgttcaa ttaaaggaaa tgcgtcatct ggacttggag aaggagataa 2947381 taccactctt cctccagcgt ataatacgcc gagaacgccg ggtgagctca gcggataatt 2947441 gtgtgccatc ggcagcgcgg ccaagtacac cgtgctgtgg tcgagccagc agacctccac 2947501 actccgcttc aggctgtata tgtagtcatc gtgggtcctc ggaatcagtt tcgatagccc 2947561 ggtgctcccg ccagaaagct ggaggaacgc cacatccgat gatttgactt caggcagttt 2947621 tacaggttct gcatgcaaat cctccagcgg taaaaattcc tctgcctcac ctgcgacaat 2947681 gatgtttttc aaagtcggca gcttgctttg aacctgtctg gcaagcgaac ggtagtcaaa 2947741 accggaataa gcgtcgggaa tgatatatgc agccgcttca gcaaactcgc aaaaatatgt 2947801 aatttcactg cttcgatgag aaggcagtgc gaagactgga agcgccccca gacggaaaag 2947861 cgcgaaaatg acttcaaaaa actctttgat atttggcaac tgcaccacaa cacgatccat 2947921 ctgttgaatg ccgagctttt gaaatccggc agccaggcga tcagcccttg tgtcaagctc 2947981 tcgatagctc caatgggtgt ttccgcatgt aatggcaatg cgatcaccat atttggctgc 2948041 ccggtccctt aacaaatctc caaacgtctc accggcccag cagccgttct ttcgataggt 2948101 ctcagctaac tcatcaggcc aaggcgtaaa tcctttcagc atgttgtatc cctccagcaa 2948161 ttcattctgt tcatatgtga tccacgccca ttgcccgcag cattgtccga aactttgcgg 2948221 acgtctcctg aagctcgtcc tcaggctttg aaccggccac aacaccagct ccagcataca 2948281 ggcggagtga gcgttcttct gcttctgcac aacggatggt cacgatccat tctccgtcac 2948341 cggcatcgtc acaccatccg accatgccgg taaagaaacc gcggtcaaat ggttcaatgc 2948401 tgagaatcgc ttctcttgca agatcagtcg gtgttccgca gacggctggc gtcgggtgga 2948461 gcgccgccgc caattcaagt gcggttacag acgggtcgga aagctctccc ttaatcacgc 2948521 tggacaggtg ccacatcgtt tccgttttga tcagtgaagg cttctccgga acctccagcg 2948581 tccggcagaa aggtctcagc gctgccgcaa ccgcgtcagc gacaaccgcg tgctcatgaa 2948641 gatcctttgc ggaagaaagc aattcagctg cccggcgctg gtcttcaaca ggatcattac 2948701 tgcgcggtct tgagccggct aatgggttgg aaacgacctg tgttcccatc cttgaaacga 2948761 gaagctccgg acttgctccg agcaatgttc tgcggggaga cgtttcctcc tgactggaca 2948821 cgtctgcggc aaacgtgtag ccatgcgagt tatgctgagc cagatggcga agcaattcat 2948881 ccgtctgaat cggttcaggc gatgtcaaat gcagcgatct ggacaggacg attttgctga 2948941 gtgttccatc ggcaatgcgt gccagccctt gttcaacacc atttttataa tcctcaggtt 2949001 caggaacagg ctttatgtgg tatgtatgcc cagcctgctg ttccttttcc tcatgatcaa 2949061 attgaagcgg tcctgaccag cgcacttctt caggtacaac gagccgcgct gcttttactt 2949121 gatcaaaagg aacggccccg acaacaagcg gccggctttg ccctgattgt tttgcctgac 2949181 gtaacgcctc tgcaattcgg ccagaaaggg tttccatttg gttttgcccg tctgcctccg 2949241 gtacaatttc acatatgcct ttcgctaaca gtacacgatg aggagacgct aagaaaaagg 2949301 cgcccggctg atattcatga agcaaatgct ccgcttttgt ttctgttata acgttttgat 2949361 ccaacattct catgaacctc ctttaaattc agttacacgc ctaaggtcgc gccgccatct 2949421 acgcataaat tatgcatcgt aatatgccct gcctggccag aaaccaaaaa gagcaccgca 2949481 tccgcaatat ccgaaggctt ggctagtttt ttgagcggga tccctgtttt aaatgtctca 2949541 agtgatcctt ttatgacttg ctccgctcca ttctcgtcgg cccataatga ccactgcatg 2949601 tctgtttccg ttgatccggg agatacaatg ttgcagcgaa tattgtattc tgcaagctca 2949661 aggccaaggc atttcgtaaa catcacagcc gcagcctttg aagacgcata tgccgccata 2949721 gatgttcttg gtacaccggc agcattcgat ccgactgtta caatcgaacc cgatcttcgg 2949781 tccatcatat atttgctgac tgaacgcgag gcgttaaata cgccagtcga attcactgag 2949841 aacgtcgcct cccattcctc atcgctaagc gaatggatca gtcccgggcg aaggacaccc 2949901 gctacattca ctaaaatatc aatcggcccc atttcacgtt cgatgcgcgc cgtgatctcg 2949961 tcaatcgccg cgctgtctct cacatccgca ggaaaagctt ctgcatggcg gccttctgct 2950021 ttgaggctgc tcacaacctt ttccagcttt tcaggattat aatcaactgc cgcaatatgt 2950081 gcgccttgac tggcaagcgt ccgcgcaaca gcttcgccta ttccttgggc agcccctgtt 2950141 ataaaagcaa tttttccctc tatacccttt gcattcatat catcaattcc tttcttcgct 2950201 ctaaatgcca aacagacatc cagcgaaaaa gactgctgcg ccttgaaaaa cgcaatctat 2950261 tgataatgat tatcattatc aattataaaa ataatcatat ccaaatgtca tgtgacagtc 2950321 aaatataatt tcagtgacaa atattttttt aaaggcaagg ctgagtatgt ctcagcccat 2950381 tgatagatgc ggtccgtcag ggtgaagcgc aaaacgcagc gccctgctga ccaaaacagg 2950441 aagaactgaa atatgtcctt ctcctgaaaa ctcgcaaaat tctgcccgta taccttgttc 2950501 agataaaacg gccagccgct cataaagctc ccttgcatta tcattcatcc ggcttttatg 2950561 atgctgctct aattctcctg cggcaagcag gatattgata ggctgattgt ttttcttggt 2950621 gagagagacg aaatggtccg ttttcttgag aataaacggt ttattccaat gaatggacgg 2950681 acttcccgcg atatacgttt gaaacgcatc gggctttgtt agcagcacct gcagcacgaa 2950741 aagccctccg agcgaatggc caaagattgt ttgtcttttt ttatcaatct ggtaatctcg 2950801 ttctatctcc ggttttaaat cctcttcaat aaatctgaaa aagccctccg ctccgccatg 2950861 ctccggccat tctctgccgt cgggcctttc cggcagcttc gattgggctg ttggcattgt 2950921 aaaatcccgg tggcgtgctg aggagaacgg ctccgctgtc tcatagccaa tgccgacgat 2950981 cactgcaggg atcaccccgg ttttttcggg tcggcgtccc tgtattcgaa cggcttccgt 2951041 catcgttccg aagacagaat tggcatccag cagataaatc acaggataac cagcgggtgg 2951101 cggcggcgta ctaggtttcg agataaaaat gtgataggta cggttttcat tgcgtgaaga 2951161 catcatacgc acttccgtac caggaatcgt aaatgcgttt gatgtcccgc catttgtccg 2951221 gtctgttgtt tgttctttca tgcagtacga cattcctctc cttaaactaa accgcaatgt 2951281 atgataatga ttttcactat caactagaca cctcaaataa taggttttct tccaaagaaa 2951341 gtcaactttt tcccgaataa aaaaggcacc ttgatcaaat aaggtacctg cagactatca 2951401 atatggaagt aaaaacctaa taaagatgcg tattgtccta tttgaaatag aaccttaatc 2951461 ccatgtaaac ctttgatttt gccaagggtc gcctctcatg tgatagccat tccgctccca 2951521 aaagccaggg tgattttctt tcgtaaattg gatgccgcgc agccacttgg cgcttttcca 2951581 aaaatacaga tgcggaaata caccccgcag cggaaagccg tgttcagggg ttaaaggttc 2951641 gccattatgc gcataagcca gaagggaagt ttccgctaag aaatcatcaa gcggcagatt 2951701 ggtcgtccag ccctcttcag catgtaaaat gacgtagccc gcttcttctt ttacacccgc 2951761 tttttccgct atatcacaag cccgcacgcc ttgccacaca ttatcaagcc ttgaccatcc 2951821 cgtgacgcaa tgaatgtcgt ttttcgattc ataccgtgga aaggctttga catcttcaaa 2951881 gcttagcagc atcggatggt caaccaaacc gtatacttga agattccatt tcgtcatatc 2951941 ttcgtaatat gggacatctc cggtatgaag cacaggaaat gaagtggtga cgttttgatt 2952001 tggcggcact cttccagatt gatcggactg tcttgttttt ccgaaataca tatgggcctc 2952061 ctttttgtta acctaattta aaatcatgtt gacaatcttt ttgttcttta ttactctatg 2952121 attgtgtatg tcaacctaag ggggaacaac gatgaaacaa cgtaaacttc gtgcgggaga 2952181 tatggcgctg attggcatgt tcgccgcact tatggctgtc ggggccaaca ttacatcagt 2952241 agcacccttt ttacaagtag ccggcattcc gctttcgatg cagccgtttt tctgtctctt 2952301 ggcagctttg cttcttggca gcaaacgggc agcgattgcc atgattgtat atgcacttgt 2952361 gggattggcc ggagcgcctg tgtttgctca attttcagca ggcttcgcac cgtttgcagg 2952421 gaaaagcggc gggtttatta tctcatacat tccggcagca tttgcagcgg gatggttttt 2952481 agaacgaaac attcagccaa gtaaaattcg atttctcatt gcttcactta tcggaacggc 2952541 gatcatgtat ctcatcggca ctacctatat gtatcttgca ctgaagctgt ggattcatac 2952601 gccagtgagc tacggcacgg cttggggctt tatgatttgg tttatggtaa aagatacagc 2952661 gctggctgtg atactgtcgt ttatcgcacc agcaatctac cgctctattc ataaagcaac 2952721 cggctttaac agaaatcaca tatcatctac gtaaaaaccg ttctattgga cggttttttt 2952781 atcataacga gaaaaggctc cccagtaaag gggagccttt ttcctataaa acaagcgctg 2952841 caatccagcc aaagatgaca agcggaatat tataaaatat aaatgtcggc acacaagtat 2952901 cccaaatgtg gtgatgctgg ccgtccgcac tcaaacctga agtcggccca agcgtactgt 2952961 cactggcagg tgaaccggca tcgccaagcg cagcagcagc cccgataatc gcaatcgttg 2953021 ccatcgggct gaatccaagc tgcatgcata gaggcacgaa aatggttgtg ataacaggaa 2953081 tggtcgcaaa agaagatccg atccccattg taattaataa gccgacaatg agcatcagca 2953141 atgcgcccaa ggactgactg tgtccgataa aaccagctga cgttttgacc agtgactcga 2953201 catctccggt tttcgtcaat acgtttgaaa atccggctgc aacaagcatg acaaagccga 2953261 taaaggccat taaaaccatt ccatcagtaa tcagtgagtc cgcttcatca cgcttcatca 2953321 caccgctgac aaacagaaca atcagaccag cgagcgcccc cataatcatt ccttctactc 2953381 ccaaagtctg agataagtaa agctggacgc cgagtgacac aacaatggct agaaccgcga 2953441 taccaatact ttttctcgta tatggcgatg cttctgcacc tgaaatgtct tttgtttcat 2953501 attgtttcgg tttacggtat acgatcactg ataaaataag gccgacaacc atacctgcaa 2953561 ctggaataat cagtgcgtac ggaatatcag caagcggaac gtttaacccg gcatccgcca 2953621 tattgtcctt cagcatgcct tggaagattt ggccgaaacc gaccggaagc aaaatataag 2953681 gagccgttaa gccaaatgta attacacacg cgatcagacg gcggtccatt tcaagttcat 2953741 taaagatttt caaaagcggc ggaatcagca ccgggataaa cgcgatgtga accggaacga 2953801 cgttttgcga aaaacaagat acaattaaaa taatcagcac aatcagcacc ttagacagtg 2953861 ctttttttcg agaatcttct ttatttccga ttaatttaac ggaggcttcc accattgcgt 2953921 ccggaagacc cgttttcgtc aaagcggcgg caaacgcgcc aagcatggca tagctaactg 2953981 caacggtggc atttccgccg agaccgtctg tgaaagcttt aaccgtttcg ccaagaccga 2954041 gcccgcctgt taacccgccg gccaaggcgc ctataattaa tgcgataaca atattgacac 2954101 gcagcaggct taatacaagc ataagcagga ctgcgatgac gactgcattc atgatgatac 2954161 ccctccaaaa atcctttagt ttgctaatgt agtagataaa taaagtacga acgtatcgta 2954221 tcataaccga tccactttag tcaactaaag atttcggaag aaaaaatccc tgccgcatca 2954281 tacagcaggg atttttcatt actcgttttt atcttcttcc aatgtaaatc gctccgcaag 2954341 tgtagccagt gttcttgcca taacgccagt agccccggcc ggtccgaagc aggttgcttt 2954401 attggcagtc gctgtgcctg caatatcaag gtgaacccaa ggtgttgact cagcgaattc 2954461 accaagaaac gttcctgcca taatcgcatg tccctcgcgt cccggtgaat tgctgagatc 2954521 cgccatttgg ctgcttttca cgcgtttttt atccttctct gttatcggca gctgccagat 2954581 cgcctcgccg cactcttgtg cagcatcagc tacctgctgg taaaagcttt gatcatttgt 2954641 cattgcaccg gttgtttctg ttcctaatgc cacaacgacg ccgccggtaa gcgtagctac 2954701 atcgacaaga actgatgcgc catgctgttt cgcgtatgta atgccatctg caagcactag 2954761 ccttccttca gcatccgtat taaggatttc tattgttttt ccgcttaaag atacgatcac 2954821 gtcatccggc ttcatggccc cgccggagat catattatcg gttgatggaa taacgcacag 2954881 cacgttttgt tcaggacgaa gctctccgat cgtttccata gccccgagaa ccgcagctgc 2954941 tcctcccata tctgatttca tgccaacaat tccagatttc gttttaatgg agtagccgcc 2955001 tgtgtcaaag gtaattcctt tcccgactag tccgacgacg tcttcccatt cctttttgcc 2955061 ctgatatttc aacacaatca ttttcggcgg ttcggtggag ccttggttta ccgcaagtat 2955121 tccgcccata ccgagctctt ccatctctga tttctccaat atctcacact caaaatcata 2955181 tttcgccgca agctcttcag catacgaagc gaggtcagtc gctgtcagca tgtttcccgg 2955241 catattcaca agcgttctag ccgaatttgt cccttgtccg tatgcctggc cgacgcgaag 2955301 ccctgcctgc acttcctgtg tatcttcatc tgttacaaca tacacggctt caatttgttt 2955361 gtcaggctca tttgatttat gcttataatc ctgcacctca taggaagcaa gcaggcagct 2955421 ctcagctaaa gcatgagcgg catcggctgg aggcacgtct tccgaaataa acgtatcaag 2955481 cagaacagca gtttcttgtt ttcgatcttt atgaatggct tgaaaaacat gagcaaaacg 2955541 ttccttcgcc tgttcaaacg aataatttgc ttctctcccc aggccaacga aataaatccg 2955601 tttcataccc gcagaagatg gagggaatac ttttgatact tgattcggtt tcgcagagac 2955661 atcaccctct tttaaaagct gtgtcagatg gccttcgagc atttcatcaa tttccaacgc 2955721 ttttcctgtc agctggcttt tttgaaaaag cccgacaaca agggtttctg tatgctctga 2955781 ttgttgaacc gcataaaaca tgaggcttac actcctaacg taatgggtat ttgtaatgaa 2955841 caatggtata ataggaaaaa cattctttcc actatactta ttttaacaaa caacagtcta 2955901 agacttgctt ttttcttttg aaacacgaag gatttttcaa atagaaagga tgtcgccgat 2955961 ggaactttta acgaattttc ctttattatc aagcctggcc gcaattattt ttgctcaggt 2956021 catcaaagtg cccatacagt ttatcgtgtc cagaaaactg gactggtcgc tggtcacaag 2956081 cacaggcggc atgcctagct ctcactccgc agcggtcact gcgctttcta caggcgtagc 2956141 cttggagcat ggattagact cctcactctt tgcggtttcc gccattttcg ccgtcataac 2956201 catgtttgac gcaactggcg tcagacgtca cgccggtgag caggcaacag tcattaataa 2956261 gcttgttatt gattttaacc gtttcgtaaa tgaagcgaag gacttcccta aggctgcaga 2956321 gaaagaaaag caaaaaaagc tgaaagagct tctcggacat cagccgatcg aagtcttttt 2956381 cggaggatta acaggtattt tactgacatt ggtactcgct tactttttca tgtaaaaaaa 2956441 acgctcctgc tttcgctgga gcgttttatt ctttcaccgt tttatattga tttctgaaca 2956501 cttgcaaaga ttttgtttca ttgagcttct caagctcatc ctcggtaatc tttcccgttc 2956561 cctttttaat cacatataca tcaagggttt ttttgcccca ttcattgtat acatctttga 2956621 ctgtctcaaa gtacagatca aggcggtttc ccttaatagc tgatcctgtg tcggccacaa 2956681 ctccgagacc gtagttcgga atgaataaaa ttgttccgat cgggaaaacg gacgggtcag 2956741 cagcaaccgt ggaatataaa tcccgtttca ctttcacacc tgaatatgta agcccgtata 2956801 atggatcacc gggatttttg cccgtcgact cagctcctgc tgtgtagcct gttgctgtta 2956861 ctctttggac tggatattca tcccaatcaa atgcctcttc taacggtttt gttttatcct 2956921 cagccgcgga cgtggtttgt gtttgtttct gctgcaatgc ttttaatctc agtcctgcat 2956981 gcttcaagtg cttttcctga tgttcctgca cccattttga caagtccttc gcttcaattc 2957041 ctgacactga taaaaatgtc gtgccaaatg caagcagaaa taaacaggtc atcagcaaac 2957101 gtctgatcat attcaacatc attcacctct cctccgaatc attgttccca agtggagaga 2957161 gcattattca aaatggtgaa tgagctgaac gcataaaaaa agctttcttt agaagaaagc 2957221 ggcatttaaa acatttgata tcctcttttt ctaagcatgt tgatcgctat accggacacg 2957281 atggcgccgg ccaaaccgct gactaaaatc agcacatcag cagccgctaa tgataagaca 2957341 cgatgaaaca ggctggcaaa ggattctccc ggcgactgga catagctgat cagcttttct 2957401 ttgctgataa tgaaaaggca tacaattgga taaatcacag ccataatcca agacattctc 2957461 agcagcatgt ttaataagaa accgattcca aaaaacaaga caaaaaacaa aacaattgag 2957521 atgattacga ctggcagact aatcaaccta ttccaccccc ctgcgttgtt tttagtgtaa 2957581 cgcgggggct gaaataaagt caacggctgg aaaaagaatg actgtctttt cctgtcccct 2957641 ggcaagacgg acaagtctct gaaccgccga gaatcaattg aaaatatcct ttccctgaac 2957701 aaaatgggca tgcatgtgaa gcggttgtcg ttgcagtttt catctaatca tcaccctttt 2957761 tcttaatttt ctgataatat accatatcaa gctgtcaaca ataaagtcag atcatgtgac 2957821 aaatcttttg atgtaagcgg aaacatactt gttttcctct cgttctcttt ttattttggc 2957881 gttttttaat aaagaaaacc cgcttccgcg ggtttttaga aaaacttgaa cttgcctttt 2957941 ttcaatgtca gtccgagtcc gccaatcata aacagtgagc ggttatcaat gacttttttc 2958001 ataaacgaag cgggcgtgcc tttcagcttt ctgccataaa caaccccaac cgcgttatgc 2958061 tcgccaagag aagccactgt tcccttaatg tccggcttga attcctcaag ctctccgcct 2958121 ttaataagcc tgccaaggtt tttagcgacc gttatgccct gctgcattgc aatttgcgca 2958181 gtcggcggat acgggcgctc tgtatcttca ttcataaaca gcgagctgtc gccgagaata 2958241 aagacattgt catgtcccgg ggcgcggaga tcagggttga ctttgactcg gccgcgcata 2958301 ttctcaaaac cggcttcctc cacaatcgga tggccgcgga cacctgccgc ccatacaacg 2958361 gtttgcgatt tgatctgctc tggttcttca tcttttttgc cgactctgac tccttctggt 2958421 gtacattctt gtacagccgt tccgatcttg aactcaactc cgttttcctc aagataatgt 2958481 acggcgtaat caacaagttc cggatcaaag cccggcaaaa cggtcggcgc tgcttccaca 2958541 caaatgatgc ggacaaggct tctgtcaacg tcatattcct tacagagctc cggcacgcga 2958601 gcagccagtt cgccaagaaa ttcaattccc gtaaatccgg caccgccaac aacgatcgtt 2958661 aacctgtccg gccgtttttc cgcttccgta ttgtaagtcg caaactgcag ctcaatatgt 2958721 tcccgcagca ggcgcgacgt gttgatgttg gcaatcggaa acgcatattc ttttaagcct 2958781 ttaatgccga acgtttcagg cacggcgccg agcccgatga ctaaataatc gtactgcaat 2958841 tctccattcg caagcacaac ttttttctca tcaattttga ttgcctttac ggtatcctgt 2958901 acaaaattca cccgtgactg gttgattaca tcttttatct gataacggca gcggtcatga 2958961 tggagcgtac ccgcgctcgc ttcatgcatc catgtcgttt cataatgata attgtgttta 2959021 tttacaagcg taatgtcagc atcattcggc ccgacatact tcgtcagcct tgtcaccgtc 2959081 atcaatccgc catatcctgc acctaaaatc acgattttgg gcttattcaa tgccatcaca 2959141 tccaccttct ctttttttgc ttttgttaga cccataataa aatcatcatt tgtgttagct 2959201 tcagcttatt ggcgggattt tatgaaatat attgaaaagt tttttgtgaa gtccttaccc 2959261 gtagcactat tatcatgttt atccggctgg cccaagaaac attcagaaaa agatcatttc 2959321 atttggttat tatcgtagcg gcctgcggaa atattttcaa gaacggatgg gcacgttaga 2959381 tccttacgat tttttctgct gactcgtcaa tttgaacggc aatatggtat aattaataac 2959441 aattttcatt taggaggcaa ttttcgtatg cgagaggata caaaggttta tgatattaca 2959501 attataggcg ggggaccggt cggcttattc accgcttttt acggcgggat gagacaggca 2959561 agcgtcaaaa ttatcgaaag cctgcctcag ctcggcggac agcttagcgc cctataccct 2959621 gagaagtata tatatgatgt agcgggattc ccgaaaatcc gcgcgcaaga gcttatcaat 2959681 aacctaaaag agcaaatggc gaaattcgac caaaccattt gtctggagca agcggttgaa 2959741 tctgttgaga aacaagcgga cggcgtgttt aagcttgtaa caaatgaaga aacccactac 2959801 tctaaaacgg tcatcataac tgcaggaaac ggcgcattca aaccgagaaa gctggaactt 2959861 gaaaatgccg agcagtatga aggcaaaaac ctccattact tcgttgatga tctgcaaaaa 2959921 ttcgccggca gacgcgttgc gatccttggc ggtggagatt ccgcggttga ctgggcgctt 2959981 atgcttgagc caatcgcaaa agaagtatcg atcattcacc gccgcgacaa gttccgagcg 2960041 cacgagcaca gtgtggaaaa ccttcatgcg tcgaaggtta atgtcctgac accattcgtc 2960101 cctgcggagc tgatcggcga agacaaaatc gaacagctag tgcttgaaga agtgaaaggc 2960161 gaccgcaaag agattttaga aattgatgac ttaatcgtca actacggttt cgtttcatct 2960221 cttggaccga tcaaaaactg gggcctggac atcgagaaaa attccattgt cgtgaaatca 2960281 acaatggaaa caaatatcga aggcttcttt gcagcaggtg acatttgtac atacgaagga 2960341 aaagtcaacc tgattgccag cggcttcggc gaggcaccga cagcagtgaa caacgccaag 2960401 gcttacatgg acccgaaagc ccgcgtacag cctcttcact caacaagtct ttttgaaaat 2960461 aaataataaa aaaaggagct tgtgtctgcg acacagctcc ttttttattt gaagatattt 2960521 atataattca atgcagttcc tacaaccagc gcaatcacaa gggctgcgac tacccagatc 2960581 attgccataa taatgcggtc ctgaatcttt tgggacttcg gtgttttttc ttcgttttgg 2960641 gccatcttat tcgctccttt cccatgtcca tgccataaag aaagcctggt gctgaacgac 2960701 caagctttgc tgaacgtata tcattcgcgt tttgatccgc tctctaagac cattcgttaa 2960761 aactatgata cctaaactca ccctgcatga caagcttcgg cacttgcacc acacctgcca 2960821 gcaaatcata atgtttgaca tcctaaataa aacagagtac attatataag gcgaacattt 2960881 catatattat acttttaaat attcgttttt aggagtgaaa accatggaaa acgtatttga 2960941 ttacgaagat attcagctaa ttcctgcaaa atgcattgtg aatagccgtt cagaatgtga 2961001 tacatccgta cgtttaggcg gacatacatt taaattgccc gtcgtccctg ccaatatgca 2961061 gacgattata gatgaaaaac tagcgatttc attagccgaa aatggctact tttatgtgat 2961121 gcaccgattt gagcctgaga cacgaattga ttttattaaa gatatgaacg cacgcgggtt 2961181 attctcttct atcagcgtgg gcgtcaaaga tgaggagtat gaatttgtcc gccagctggc 2961241 agaagaaaat ctgactcctg aatacgtgac aattgacatt gctcacgggc actcaaatgc 2961301 tgtcattgaa atgatccagc accttaaaaa acatttgccg gacagctttg ttattgctgg 2961361 caatgtcgga acgccggaag cggtcagaga gcttgaaaat gcgggagcgg atgccactaa 2961421 agtcggcatc ggaccgggaa aagtatgtat tacgaaaatc aaaacaggct tcggcacagg 2961481 cggctggcaa ttagcagcgc tgcgctggtg tgccaaggct gccagcaaac cgattatcgc 2961541 ggatggcggc atccgcaccc atggcgacat cgcaaaatca atccgattcg gcgcaacgat 2961601 ggtcatgatc ggttcactat ttgccggaca cgaagaatcg ccaggccaaa cgatcgaaaa 2961661 agacggaaag ctttacaagg agtacttcgg ctcagcctct gaattccaaa aaggcgaaaa 2961721 gaaaaatgtc gaaggcaaaa aaatgcacgt ggcgcataaa ggctcaatca aggatacact 2961781 gattgaaatg gagcaggatc ttcaatcttc tatttcttat gcaggcggaa caaagcttaa 2961841 cgccatccgc aatgtggatt atgtgattgt gaagaattcc atttttaatg gggataaata 2961901 ttaatcataa aaaaacgcca agtcagcggt tctccgcttg agttggcgtt ttctgctact 2961961 tcttcagcaa agtaagctta tatttgcttt ttgagtttat cttccatcag ttctgccatt 2962021 tgttttgcat ttggattttc ttcattttgc aactgttcaa tgacgttcat ataatccgtt 2962081 tcatttcggt tctggcttaa tttatatgcc gcttgaatgt cttccacctt aatcttaaat 2962141 ccaacaatac ctttcaattc actttctaag agttttggag aaagcttatc ccataacaca 2962201 ggattgtcac gatgtttttc gtatttctcc aacatgattg ttaattcttc tgctaattca 2962261 tctttctcta acatacttgc ttttccatac atgtggacag cctgataatt ccacgtcgga 2962321 acattttcgc gcgaatacca ggaagaagaa atataagcgt gcggtccctg aaacatcaca 2962381 agcacatctt cacaggcttc aaacgttctc cactgaggat ttccataagc gaaatgcccc 2962441 gtaatatagt aatgatcgtc ttttttattg aatcctaacg gcaaatgtgt ggcaattggt 2962501 tttccttgtt ctgttgtgac aaccgtacca aaggagtttt cttgtacaaa attccaaatt 2962561 tcttcagcat ttgtgacttt aaaatatttt ggaatataca tcatcatcca cccttcgaaa 2962621 aatattatat gagtgtttta gccatgatta aatccgtttg ttcttcatca cccatataaa 2962681 atgagtgggc gccggtctga acaaacccca ttttcttata aaaggcaatg gcattttcat 2962741 ttttttccca cacacctagc caaatgttct ttttattacg ttccagcgca atttctatcg 2962801 ctttattcag cagatgtttg ccaagcccat gtttttgaaa gctgttcttt atataaattc 2962861 tctcgatttc aagtgattca gcacccattt cttcagactg agcatcatcg atattgacct 2962921 ttacatatcc agcgatttca tgatcaaagt aaataaaaaa gaattgcgaa gacatattag 2962981 ataactcttt ttccagctgc tcagtgttaa atgcgctttc taaataggct ttcatatttt 2963041 caggtgagtt ctgttcttta aaagtgtcat tgaatgtttc aatactcaat tgttgaagtg 2963101 tttgtaaatc ttcccggctg cattttttca tttttacact cattgttcgg attcagcccc 2963161 tttatttaaa attcaattgt cttgtgtccc ttttatatat ttaaacacgg aacacatact 2963221 gaccttgtta ccattccaaa aatcttcttc atcaccaact ccctatcgtg attttgttgt 2963281 aaatgcaata aaatatactc cgcattaaat atatcgtaac tttgctgtat ttacaacaaa 2963341 aatcaaacaa caaagcagcg tttctcttgc cgaagttccc ggaactctct gcatcatttc 2963401 cccataataa aaacgcctcc cttaacgatg atttatcgct aagaaaagcg tcagtaatag 2963461 ttgctatccg tttttagtgc ttagcactct tcaggcttgc ctgcattcgt tgctgttctg 2963521 aacgaagaac cgcagccgca tgaagcgatg gcgtttggat tgtcgatggt gaagccgccg 2963581 ccgagcatgg attgtttata atcaatcacg gtgccgttca tgatgtcaag gctttctttg 2963641 tcaactagaa cagtgatgcc gtgctgatca aacacactgt ctgattcact cttttcatgc 2963701 tcaaagccca tgccgtaaga aagtccgctg cagccgccgc ctttgacgcc tacacgcaga 2963761 aacgcgtttt cttcttcatg ctctttcatc atatctttta tatgcaaagc tgctgcttct 2963821 gtaattgtta ccgggttgct catcattatg aacctccttt taaaaaccgg ttgctgtctt 2963881 ttattataaa catgatcgtt ccaattctca aacaaggtgt tttacaagaa atagacaccc 2963941 tcacaaacgg tttcagccgg ccctgtcatc attacatggc cgttatcttt ccagtttatc 2964001 accaaatccc cgcctgctaa atgcaccgtg atgtcttgat ttcgctttga tacgccgttt 2964061 aatacagatg cgactgccgc tgcacatgct cctgtcccgc atgcctgagt aatccctgat 2964121 ccccgttccc agacgcggaa atgcaattct tgttcattca cggtttcaac gaattccaca 2964181 ttgatgcctt ccggaaatct cggatctttc tcaatcaccg gccccagtgt cgttaagggt 2964241 gcctgttcaa tgtctgcgat cggaaaaacg atatgcggat ttcccattga aacggcagtg 2964301 cctgttagtt ctacttcacc aaatgccatc gtttcattga ttgtgtgctc ttccccgccg 2964361 tcaagcatag gaagctcgga ttttgtcaag cgcggttcgc ccatatcgac agtgaccaca 2964421 ttcacttttc cgttttcgac ttgaacctcc gctttcacaa gcccggagag agtttcaatc 2964481 agaaaagatg tttcctcaac cagcttatgc tcatatgcgt attttgcgac gcagcgcagg 2964541 ccgttgccgc agtttttccc ttcagacccg tcattattaa aaatccgcat tttaacaggc 2964601 gcttggtctg atgggcatat caggatcatt ccgtcggatc cgatccctgt ataaacagaa 2964661 gaaacctgaa ttgcaatctc tgacagtttt tcttctggaa gctgttcttc aaattgattc 2964721 acataaatat aactgtttcc caggccgtgc attttggtaa atcgaaatga gttcataggt 2964781 gcctccaact ttttttcttt ttcttagtat aaaagctatt ataagcggac acaatacaat 2964841 tatcccccgt ttttcataca taaaagctcc ttgcactgac gcaaggagct tttatcgttt 2964901 atataaacat gccggcaatg gctgcgctga gcagattggc taatgttcct gcaagaacag 2964961 ccttcaggcc gagacgtgcg atatctgaac ggcggctggg cgctaaaccg ccaagcgtac 2965021 caagcataat cgcaattgat gaaaaattgg cgaatccgca taacgcgaaa ctgataatgg 2965081 tagcagtttt cttagaaaac tcgccgatgt gcgaaccgaa gttagaataa gcgacaaact 2965141 cattcagcac caatttctgg ccgatatagc ttcccgcctg caatgcttca tgccaaggca 2965201 cgccaatcaa aaaggcgata ggagaaaaca catagccgag aatggattct aatgttacgc 2965261 cttttaaacc gaacaagccg aaagccccgc cgagaatacc gtttactaca gcgattaacg 2965321 caacaaacgc aagcagcatc gccccaacat ttaacgcaat ttgcagtcct gttgacgctc 2965381 cctttgcagc tgcgtcaatg acattggctg cgccttcgcc ttcatccatt ttgaaatcgc 2965441 tttttacggt ttgcgttttt tccgtttcgg gtataatcaa tttaccaaag actagtccag 2965501 ctggagcagc cataaagctg gccgccagca agtactcaat cggaataccg agaagcgcgt 2965561 acccaaacaa ggtagatccc gcaactgccg atagaccgct cgtcataatc gtaaacaact 2965621 cagagcgcgt cagcccggca atcaggggtt tgatcactaa cggagattct gattgtccta 2965681 caaaaatatt ggcagcagcc gccagagatt ccgttttgct tgttccaagg agcttcgaca 2965741 atccgccgcc aatgacacgg aaaacgagct gcatgatttt caaatgatat aaaactgcaa 2965801 tcagtgctga gaagaaaatg ataacgggca gtacacttaa tgcaaatgcc ggactgtctc 2965861 cgacctttag aagcggtcca aaaataaaac tgatgccttc attcgcatag tcaatcagaa 2965921 gctgtacacg gcttgaaaac cataaaaaaa cagcgcgtcc cgcttcccat ttcaacacga 2965981 tgtatccaaa cgccacctgt gtgcataaac caacgatgac ggttcttatc ttaatattgc 2966041 ttttcttttc tgaaaataaa aacgcgatag caatgatcgc aactgcgccc agcagccccc 2966101 acagaacatt catgaatact cgtacacctc ttaaatttta tttaaaaaaa tatcttttat 2966161 acgataacaa taatattttt tgatgtctac acattttttt agttcttttg tacggcaaaa 2966221 taaaaaaggg cctgtccagg cccttttctt taaaacattg gattttcttc aataaaggta 2966281 tatatattct caacaagctc agcaggcgtt tcacccatga cgacttctcc gtttaccaga 2966341 gcgaaaagcg attccataca tgtcccgcag tagcttaagc agccatattc aaggacatca 2966401 aggttgggat ccttctccaa aatcgcccgg gcttcctgag agccgtgagc cagattgctg 2966461 acacaaaatt caatcattgg attcatgcgg tttcacctca catatgtcca ttatcgcgaa 2966521 tttttcacta ttcgtcaaag acaacggatg attcaaaatt tattatcgta acatattatt 2966581 tctcaaataa cgttttacta atttgtgttt tcaggctaaa ttgtaggtta ttttgaaact 2966641 attattgtga ttttagatca aattcgatat aattctagat gttattttac atagttcgta 2966701 ttttcttcaa tgtatctatc atactcttcg gattaaaggg gaattcaaat gaaaaaattg 2966761 gtcttgatcg gcggaggtta cgggaacatg cgcgttcttc atcgcttatt gccaaaccag 2966821 ctgcctgatg atgtttcaat cacgttaatt gacagaaatc cttatcactg cttgaaaaca 2966881 gaatattatg cccttgccgc aggcacaatt tctgaccatc atatcagagt gtcattccca 2966941 gagcaccctc gcctggatgt ccaatacggt gatatcacat caattgatat tgtacaaaaa 2967001 caagtgctgt tccaagatcg tgaaccgatt tcttacgatg acgccataat cgggctcggc 2967061 tgtgaggata aatatcacaa cgtgccggga gcgcctgaat tcacctacag tattcaaacc 2967121 atcgatcagt cccgcgaaac ctaccaaaag ctgaataatc tgagcgctaa tgccaccgtc 2967181 gccattgtcg gagcgggctt aagcggcgtt gagcttgcaa gtgaattgag agaaagccgt 2967241 gatgacctga acattatttt gttcgaccgc ggtaatctca ttttatcaag ctttcccgag 2967301 cgtttaagca aatatgtgca aaaatggttc gaagagcacg gtgtccgcat tattaacagg 2967361 gcaaatatca caaaagtaga agaaggcgtt gtgtataacc acgatgatcc gatttctgca 2967421 gacgccatcg tgtggacagc cggcatccag ccaaacaaag tcgtcagaga cttagatgtg 2967481 gagaaggacg cacaagggcg tattgtatta acgcctcatc ataatcttcc aggtgatgaa 2967541 catctgtacg ttgtcggcga ttgcgccagt cttcctcatg caccgagcgc ccagctggca 2967601 gaggctcaag cagagcagat tgtccaaatc ttgcaaaaac gctggaatgg agaagccctg 2967661 cctgaatcaa tgccgcagtt taagctgaaa ggcgtcctcg gttcactcgg aaaaaaagcc 2967721 ggcttcgggc ttgttgctga ccgtccgctg atcggccgtg ttccgcgtat gctgaaatcc 2967781 ggcttgctgt ggatgtataa acaccataac ggttaatgat agagaagaac cgctgatcaa 2967841 gtcagcggtt ttctgtatac ccatgcttct ccatttcctc ataaacgtct tttaattttg 2967901 gattgccttc accgacaatt ttgtcttcta caagcacaag cggataaaaa tactcgtcat 2967961 ttctgatttt ttccgcaagc tctttcgcat gttcattgtc aggcggctca tgaatatcga 2968021 tgtactgcat ctcaaaaggc tgatttggat attttctttt cagcgcagcc tcaagccact 2968081 cgtatgtatc cttggctgtc ggcatattta cacagctcgc acaaacgttt tctgccccgt 2968141 acacgcttag catgactggt ttcatcactt gtagacgccc ccttctccta tgtaagtcct 2968201 ttcttttaag tatacagagc ctaagggcgt ttttatagaa aaaaaccgtt tttgtgttga 2968261 agtctgaatg tgctataata gggaaagcaa ctttgcaaac caaacaatag atttttattg 2968321 ttacactgaa tataatggtt ttatgacgac gaaaggagcg aatgtcatga ctgaagttga 2968381 aatgaaagaa caggtgcagg aagtactgga caaacttcgt ccgtttttac ttcgtgacgg 2968441 cggtgactgt gagcttgtag acgtagatga aggtatcgtt aagcttcgtc ttctaggcgc 2968501 atgcggcagc tgcccaagtt caacaattac gttgaaagcc ggaattgagc gcgctcttct 2968561 tgaagaagtg ccgggtgtcg ttgaagtaga acaagtcttt taataaagca gccaggctga 2968621 tatttgatca gcctggcttt tttattagag atgttgatca aaccatgagc tgatataatt 2968681 caggcgcttg atccgctgtc ttgggtgtcc ggtgcgtgat aaattgtgcg atgcattcgg 2968741 aaaacggaca agcttggttt ccttgcccat ttttttcaga gcgataaaca gctgctccgc 2968801 ctgctcgatc gggcatcggt catcccgctc gccatgcagt atcaaaagcg gtgtctccac 2968861 gtttgctgcg tattttaaag gagaccggtc ccagagcttt tctgtgtcct caaacatgtc 2968921 atgctcaagc tgccagtctg taaagaaata gccgatatca ctgacgccgt gaaagctgat 2968981 ccaatttgat atcgagcgct gggtaacggc agctttaaag cggttcgtct gcccgacgat 2969041 ccagttggtc ataaaacctc cgtagcttcc gcccgtgaca ccgagccgct taggatcaat 2969101 atgcggatct cgtttgatag cctcatccac agcctgcatc acatcgtcat aatcctttcc 2969161 cccataatct cctctgaccg cattcacaaa ttcctgcccg tagccgtggc ttcctctcgg 2969221 attgatataa acgaccgcgt atcctttcgc cgccagcacc tgaaactcat gaaaatatgt 2969281 atgtccgtac atcatatgcg gaccgccgtg tatgttaaga ataagtggat atgttgtctc 2969341 accttccatt tgtgcaggcc tcatcagcca gccgttcacc atcacgccgt cttctgtagc 2969401 atattgaatc tcttcaggta ttgatatcgt atgctccctg acaaacttgt cattcgcgcc 2969461 agtcagctgt ttctcttcct gtccaagcgg gatactgtaa agctcactcg gtctgtccgg 2969521 ctttgtcaca ctggcaataa agtgctgttc atcaggtgaa agagaaaagc tattgatgta 2969581 ctctttttcc agacgaatcg gatacacaag gccttcaatc gaaatataat agatgcccgt 2969641 actgccttga tctgtgccga tgacataaaa cccttggctg tcctttgtcc aaatcgggcg 2969701 ctgttcagca ccaccgatca atgaatctcc aatcagcgca tccgctaaat gaacgtccag 2969761 catctcagta agacatgtga ggcggccttg ttcgatatca tagagccacg cctttgagag 2969821 cgtagcattc ttatattcct tttcatttcc aagcaaagca agataccttc cgtctggtga 2969881 aaatgagctt gatccgaatg agccgcgatg aggtgtaacc tgcttaagat ctccagactc 2969941 cagtgacatt atgtaaacat catgcggctt gctggcatca tctgtttcag ttaaattagc 2970001 tgagaaaaca agccatttgc cgtcaggaga aaaagcagga tcaccatgat cagctttgtg 2970061 acttgtcagc tctttcatct cacccgactt tacgctgaca agcacaagct gggcatacgc 2970121 acctctcgtc agccctttgc cgtcccgttt gtaggagagg ccttgcactt caacaggttc 2970181 atagctgtcc tgctctgttt tttctcggtc atcaatgctt tccccctctc ccaaactgac 2970241 agtgaccaga atcgattcac cgtccgggga ccatagcggc tttgacacgc catatgggat 2970301 atcagtcagt tttcttgctt ctccgccttc agtgctcatg atataaagct gtgccgcatc 2970361 gccttctcga tcagaaataa aggcaagcgt gcgcccgtcc ggagaccatc ttgggtcggt 2970421 gcttcgcttt tctccatgtg tccaaggaac agatcctccc gttttcgttt catagatcca 2970481 tatatttgat gtatacgaat ctttctcttg atttacttgt gattttacat atgcggcacg 2970541 ggtaccgtct ggggcgtatt gaggatcggt cacagagaca atcgctgtga tgtcgtctgc 2970601 ggttatcagc tttttcatat tcatctcctc ctttttacat gtatttcgtt tttctaaata 2970661 aaaactcctt tatctccagc aaaaaaaagc gccctccgct gacgctgagg aacgcttggc 2970721 atgatctata cactttttac ttgatataaa ggatttcgct ctattatact tccctctttc 2970781 ggaacggtca aagcgtctac ttcacaatga gggaaatgaa gcgcgagctg ttcttttagc 2970841 tcttctccct ttcctttttc ggtcatgacg agaatcgttg ggcctgctcc gctgagagcc 2970901 gttccatatg cgcccttcat ctcggcgacg tgctctactt ttgacagctc aggcacaagc 2970961 atcgcccggt acggctgatg gaacatatcc ttcttcatga ttttcccgac aagcggccaa 2971021 tccttggaca tgatcgcagc aatgaggata ttgctgacag cacttgcttt tacggcatcg 2971081 gcatatggaa actccttcgg aagcacgtct ctcgcgtctc ttgtcagcac ttcataaaaa 2971141 ggaatgacaa cgactacgtc aatgtcagca ttcgggacgc ggatcatttg ggtctcgtca 2971201 tcctcatgca ggccgatcac aagtccgccg acgagagaag cgccagcatt gtccgggtgt 2971261 ccttcttcta gactcgctaa atgcagcttg tccgcttcag acagctttaa gccgcataat 2971321 tcatcagcca gttcaatggc cgctacaatc gctgcggcgc tgctgccaag gccgcgtgca 2971381 agcgggatgt cgctccacac cttcacatgg acaggaggca tttcttttcc gtacaaatct 2971441 gcggtccgtt tagccacttg gtagatcagg ttatctgtac ccgccggaat tccggcgact 2971501 gtttctgttt cagcctcaaa agaccatttg tcgctttcaa agacggtcag cttcaaatat 2971561 ctgctgagcg ccattccgac tgaatcaaag ccggggccta ggttagctgt gcttccggga 2971621 acagtgacag agaacagcat gtcggcttcg ttcatacacg ggccgctcct tttacatatt 2971681 caaggatgct gtcttcatca gtcggcaatg tgacaggctt gatttctgaa atgtcgaccg 2971741 ctgtgttcgg atctttcagt ccgtttcctg ttaacacagc tacgaccttg ctgcctttcg 2971801 gaatttctcc ggatttcacc tgtttcagca ctcctgcgat agacgcgcaa gaacctggtt 2971861 ctgcaaacac gccttctaca cgggcgatca gctgatatgc gtgaaggatt tcatcatcag 2971921 tgacttcgtc aattttccca ttggattcct cggctgcctt tacagctttg tcccagcttg 2971981 ccgggtttcc gatacgaatg gctgtcgcta ttgtttccgg attttcaatc acttcattgc 2972041 gcacgattgc cgccgcaccc tcagcttcaa agccgcgcat tttcggaagg cctgtgccgt 2972101 ttttctcatg atattccttg aagcccttcc agtacgcagt gatgtttcca gcatttccga 2972161 ccgggatcgc taaaacatca ggcgcttccc ccagctgttc gcacacttcg aaggcagcag 2972221 ttttttggcc ttcaatgcgg taagggttga ctgagttgac aagggcaatc ggtgatttct 2972281 cacagatgga acggacaatt ttaagcgcat cgtcaaagtt tccgtcaatt gcgataatct 2972341 cggctccgta catgacagct tgagcgagtt ttccaaatgc aatttttccg ttcgggatga 2972401 tgacaatgca tttcatgtta gcacgggctg catatgctgc cgcagcagcg gaagtgttac 2972461 ctgttgacgc gcacataatc gtgtcattgc cttcttcttt tgcctttgcc acagccataa 2972521 ccattccgcg atctttaaat gatcccgtag gattgacgcc ttccgttttg acatgaagct 2972581 caattccgag ctgctcagac agcttcggca ggtgaataag aggtgtgttt ccttcatgta 2972641 aagttagcgc cggtgtttga tctgttacag gtaaaaattc tttatattga tggataagtc 2972701 ctttccacat tagctccaac cgttcccttc tacacgatat gtgcttttga cttcttgaac 2972761 gacttccaaa tcatttaggt tttgcaggat atcactgaaa tcagcttctg atgtatgatg 2972821 tgtgacaatt acgatttcag ctaactcatc atggccttta attggcagct gaaggatttt 2972881 ttcaaagctc acgccccgct ctgagaacac agatgtaatt ttcgagaatg aaccaacctc 2972941 atcttttaca tgaattctta aaaactgctg tgcataaatg tcagacggcg atttcatgtt 2973001 tttctcatat tgcggtccga caaagctgtt gccggttaca cctaggcgca tatttttcat 2973061 gacagcgacg aggtcagaaa caacggatgt cgctgtcggc atgcttccgg ctcccggccc 2973121 gtagaacatc gtctcaccga cagcctcgcc gtatacataa acagcgttaa actcattatg 2973181 aacagcagaa agcggatgat ggtcaggaag cagtgtcggc tgtacgctga cctcgatttt 2973241 gctgccgtca cgctgagcaa tcccgatcag cttcattgta tagccgaggc gtttgctgaa 2973301 gctgatgtcc tcgtctgtaa tttgggagat cccctttact ttgacgtctt ccagatccac 2973361 gttcatcgag aagccgaggc gcgccaatat cgccattttc cgtgcggcgt caagcccttc 2973421 cacgtcagaa gtcggatcag cttcggcaaa accgagatcc tgcgcttcct tgagcacttc 2973481 ctcgtatggg cttttctctt tgatcatttt ggttaagata aagtttgttg tgccgttcac 2973541 aattcccatc atttttgtaa ttcgatctga tgagaggcct tcctctaacg tgcgcagaat 2973601 cggaatcccg ccggcaacac tggcttcaaa gtagatatcg catccatttt ccttcgcttc 2973661 ggcaagcagc tcggagccgt acacagccat taagtccttg tttgctgtga caacatgctt 2973721 tttcgatctc agcgcgtcga ccaaatattg ttttgtctgt tcaacgccgc cgatcacctc 2973781 gatgacgaca tcaacatctg gatcatcaat gacatcatac acttctgtcg tgagcacttc 2973841 cttcggcaaa tctacttctc tctttttctc taaatctttt acaagcactt tttttatcgt 2973901 aaccggacag ccgacctgat gcataagctt atcctgatgg tcttgaataa ttttaacgac 2973961 accgcttccg acggtaccta aacctaaaag ccctacacga atcgctttca aaaaaactcc 2974021 acctttcttt tgattgtcct cttggaaaag acaattgtta actcaacaca gacatataag 2974081 ttacaaacat tatataagcc cgctcctgtt ttgacaagac atcattaggc tgaattttgc 2974141 gaatgtaaac gcttaacgca ttgatatgac aagattcttt attttctaat tatttttgtc 2974201 agattttctc ctcaccttga gctgcctttg ccgagccagc tgacgcgtgg aacaaacagc 2974261 ttctgcgccc gcatattcat gaattcctgc gctgtattga gaaattgttc ataacgccca 2974321 cagtcattaa gaatgaagtc aagctgttct tcaaaataat gcttttctga ttctgatgac 2974381 atgtaatagc tttctacgat ttcaaaataa tgaagcggga aaagcagacg gctgtataaa 2974441 aggcgtttcg aaaatgaaga cagcggtgtg acttgctcgt attcctgtaa aaagagaaag 2974501 ccctgctgat taaaatcttg tctgtgatgc aaaaacgtat gcctcatata ttcagccaaa 2974561 tcacgggaag cgtggtcaaa cacccaatcc gccggaatcc tgatcaatga ttccggtgac 2974621 catgtatgcc tttccatccg ctgatggcat atcgttcctg aatcagcggc ttggggcttg 2974681 tcatccagct cagtgtccac taaatattgt atcgcgtttt ctgacagtcc taaataatat 2974741 ggaaatgatt cgatcatttt tttatcgaat ggctcatgcg gaggggtctg aacctttctc 2974801 tgccaaaatg cttccagctg atcaattcgt tttccccaca gatccttcca ctggccgatt 2974861 cttccggccg ccttcacctc atatggatat cctcggcctt ttcggtgaaa ttccgcaagc 2974921 tccgctccaa tggagaacgc cctgtttgaa taaggggggg ccgccttcag cagagcgtac 2974981 gtttttccct catgttcaaa tgtcagttca ccttcttttg taaagataaa aaccgaaacg 2975041 tatgggtcac tttgttcttg taaatactga ctcatgtaat aaagctccgc cagctctgtt 2975101 tctgagaatt gggaaacggg gacaatcaga aagtatgaat taggcgtctg aaagcattga 2975161 tatgtgtgct ggtacatgga aagctgcctg atgtgaatgc cgtatttttc ttttattgta 2975221 cctttcacca tgatcacctg cctgttgaat tagggctcat cacatcgtag tcatacacag 2975281 ccggaattat gaatacatat tttaatccga agaaggcgca agaaaaagtc gtaaacttct 2975341 caagcatttt gtataaacta gtaaaaaaga ttgggtgaag ctgatgtcag aaaacgaaca 2975401 attcagtcag atggaagcta aagcaagagc acggatgaag gagcgcggcg ttgaggtatc 2975461 agacattgcc gagcttgtct tttttctgca gaaaaaatat catccggatt taaccattga 2975521 tgaatgcacg ctgaacgtca atcgtgttct cgcaaaacgc gaggtgcaaa acgcgatttt 2975581 aacgggcatt gaattggatg ttcttgctga gcagaaaaaa ttgtctgaac cgctgcaaac 2975641 gatgctggaa atagatgaaa gcctatatgg agtagatgaa gttctggcat tttccattgt 2975701 gaacatttac ggatcgatcg ggtttacgaa ctacggttac atcgacaaag aaaaacccgg 2975761 aatccttaaa cgattgaatg ataaatcaac cggtgaatgc catacctttt tagatgacat 2975821 cgtcggagcg atttccgccg cggcttcaag cagacttgct caccgcgcgc ggcatacaga 2975881 ataagggcac ccttttaggg cgcccttttt tcaaatgtat ggaatccatt cagtcagaga 2975941 gtcaatggcg tgagtcggtt tttccatatc gtctgtcata tgttctcttt tcgttacgcc 2976001 tgtgtgaacg agcagcgtat ccatacccgc gttaatgccg gccataatat cagtggcgta 2976061 gttgtcgccg accatgagtg tttcagacac atctgtgccg agaacgcgca tcgcctgctc 2976121 cataataatt gattccggct tgccgataaa tacaggctgt acacctgtag atacggttaa 2976181 caccgatgtc agtgagccgt ttcccggcag gagccctctt tcagtcggaa tcgcaatatc 2976241 tccgttagtg gaaataaagc gggcgccatt tctgattgcc aggcagccaa cagcaaattt 2976301 ttcgtatgta atggaacggt cgatgccaac aacgacaaaa tccgcgtttt ctccgccaaa 2976361 tgtcaggccg ttttcttcaa tcgcctggcg gattccttcc tccccaatca catacacaga 2976421 cgcgtctttt ttctgctgtg caatgtgctg ggcagttgcc atgctggtcg tgaagacctg 2976481 ctcttctgtt gccggaatat caaaagacac gagcttgtcc gctacctgct tcggtgtgcg 2976541 cgaagagttg tttgtcacga aaagataagg aacgccgcga tctttcagcg ttctgacaaa 2976601 ttcacacgcc tcctcgattt tttccgtgcc attgtacatc gttccgtcta aatcaattaa 2976661 atacccttta tatgttttca tatccaacac tcctgtggct ttccagttgt tatttaaacg 2976721 cggaaacagg tcctagctct gtttccaaat agcttctgat ccgtttcggg aagtcctgaa 2976781 gagctgtttg atgcgccttg atcagcctgt aaagctcgcc gctgtcagcg agcagatact 2976841 gttgaaccaa cgttttgcgg taggcgatca attttttgag ctcatcaccc tctttttccg 2976901 tgacaacttt ctcatcaaca agtatatcca taatgtcgtc atagctgccc gggtcccgca 2976961 taataaagcc gtcaatcatg tcattgcctg tatccaaaat gcattcgatt aacagatggc 2977021 ctatacgctg aagtgccaat tccccgattt cagactgcca gtctgtttgt gagtcaaata 2977081 gcgccagctg gtgctcgaag aaccctagtg ttttttcgat tttgcttctg tcaacaaaat 2977141 acatgacagc atcccctttg tgtatattta ttttctgatc cgtttcaaga caaaatacgc 2977201 acagccgaaa ttgcagtatt cgtaaatata ttcatctaat gtgctgattt tcgtttcgaa 2977261 ggttgccttt tgattctggt cgtcaaagaa gcccttgagc cttaactgac cgtatcccca 2977321 gtctcccaca atataatcgt atttatttaa tatatcggag tagcgggctt taaaagcctc 2977381 ttcgttgaag ccgtctttga aattgtgcac caattcaaat tcggcatttt gaataagaat 2977441 catgatctca cctctttttt cactcattcc tatcataatt cattgccccg tccccatcaa 2977501 ttgctaaaga ataaatcatg cgatttggct accctacaca tgaggaggga ttgataaatg 2977561 aaacgaaccg ctgtcagcct ctgcctgctg accggactat tatccgggtg cggaggcgca 2977621 ggattggata atgcccaaaa tgtccggaat cagacgcaga atcaaaccaa acccattcat 2977681 gtgtcggacc gcaacgaggc ttttaacagg cataatgaga acgaacaatt tggctatgtc 2977741 cgctatcaaa aagaacaatt tgacggagaa cagcagaaaa cgccggtgat gaaccgggaa 2977801 gaaaccgctc acatgatatc aagtttaacg gttcagctcc cccatattca agatgctgcg 2977861 acattggtga ctgaccgaga agcgcttgtc gtatacaaaa ccgattctaa aaaccgggag 2977921 ctgaccgccg atcaggtgaa aaaaacagcg gcttctgtga taccgcgata ctatcacgtg 2977981 tatatttccg ataatccaaa ccatatgcaa tccgtcgaaa attacagcaa tctcggctct 2978041 ggttcaaggg atattagaga gatcatgtcg gggacgattc aagaaatgaa aacctccccg 2978101 caaggaagcc ctgtctcaga gaatgaaaat gccaatggag aaacgcgtca ggacatgaaa 2978161 atcgatagga atgacaaaaa cgccagatga tctggcgttt tggcattatg cttgtgcttg 2978221 acgcttttta gatgcttcgt ttacttgttc atccgcatgg taagaggaac ggacaagcgg 2978281 accggcttca caatggctga agcctttttg catcgcgatt tcttttaatt ctgcaaattc 2978341 atcaggatgg tagtattttt ggactttcaa gtgtttcttc gtcggctgca gatattggcc 2978401 gattgccata atatccacgt tgttcgccaa gaggtcgtcc attacttcaa taatctcttc 2978461 ttttgtttcg ccgagtccga tcatgatact tgattttgtc ggaatgtcag gctgcatttc 2978521 cttcgcacgg cgcaaaaatt ccaatgaacg gtcgtacgtc gcacgcgcgc ggactcttgg 2978581 cgtcaggcgg cgaaccgttt cgatattgtg attcaggatg tctgggcgtg tatccatcaa 2978641 ggtttttagg ttatcgtagt ttccgcccat atcagacggc agcacctcaa ttgttgtgaa 2978701 cgggcttttt ctgcggatcg cacggacagt ttccgcgaaa atgcctgccc cgccatcttt 2978761 ctgatcgtca cgcgcaacag ccgtaatgac cgcgtgtttc aaattcataa gcgcgactga 2978821 atccgctacg cgttccggct cttgcagatc aagctcagtt ggaaggcctg ttttgacagc 2978881 acagaaacgg catgctcttg tacaaacaga acctaaaatc ataaatgtcg ctgtacgtct 2978941 gaccgcccag cattcatgaa tattcggaca ctttgcttct tcgcatacgg tatgcaggtt 2979001 gttttcccgc atgagttttt tgagccctgt atagttttca tttgtattta atttaatttt 2979061 aagccattcg ggctttctga ggtgttcgtc tttctttgcc aattcccatc atctccaata 2979121 tccaatatac tcaatttctg acacgaaaca ttctgaaaac gagaaaggtg caggttttag 2979181 ttctgcaaca aaaataatgt ttttctaact aaagaaagtc ttttctttag acactttaac 2979241 ataggaaaaa tttctcgaca agggaagatg attactgaca tttttaagcc gggttgccgc 2979301 aaactatgtg tattcaatat gaaaggagat tattttgtga aagttttgtt atccgctctt 2979361 cttctccttt tgtttgcatt tgagccttct gcgtctggaa aaaaactttc agatccagtg 2979421 ctgtcgaaac ggatggaatt atatcataaa atcgaagctg tgacgcagat cccttggtat 2979481 gcgctcgccg ctgttgatca atacgaagaa aacgtgcgga gcaaccggaa agatctgcct 2979541 gaaaaggcgg gaatcatcag catctatata cccgatgata tctggagcgg gcctgaaaac 2979601 ccgaatccga aagacgatgc gccgttaagc attaaagtgt ttgacggaat cggaatggat 2979661 ggcgatggag acgggaaagc cgaggtcagc aacgatgaag atatcttgta tacgttcagc 2979721 caatacttac tgtcgtatgg cacagatgaa gacaacatcc ggatcgggct ttggaattat 2979781 taccggcgtg atcagacagt ggggattata tctgaattca tgaagctgtt taaagcctac 2979841 ggccatattg atctgggcga gcatgcattc ccgcttccga tcagaaccga ttacagctac 2979901 cgaagcacgt ggggagatgc ccgcggcttc ggtggaaggc ggattcatga aggtacggat 2979961 atctttgccc attacggcct tcctgtcaaa tccacatgtt acggcgtagt tgaaatgaag 2980021 ggctggaacc gcttcggagg atggagaatc ggcatcaggg acattaacaa tacgtatcat 2980081 tattttgccc atctcaatgg gtttgccaaa gggattaaaa caggacaaat cgttgagcct 2980141 ggccaagtga tcggatcagt cggcagctcc ggatacggcc cgccgggaac cgccgggaag 2980201 ttcccgccgc atctgcacta tggcatgtac aaagataacg gaagaaccga atggtcattt 2980261 gatccatacc cgcatttgag ggcgtgggag cgatatgaat accaaaaaaa gaagtaacaa 2980321 aaagccgcct cttcaacagg cggcttattt gctgcttttt tctttttttg aatcggcacc 2980381 gttttctttg ctgctcggaa gctggacaga aggcgtgaca cccgagccgc cgcttccatt 2980441 ataaaactgc ggcacttcgc cctgcactgc tttaatcgat acaggaacat tatttgtgac 2980501 gacagcggtt ttgctggcaa atggaatgat gaccttcact ttaatttcga caaagatgct 2980561 gatatcaata agtgcgttat ttatgccata cggcttgatt ttggttttga catctgtaaa 2980621 agcgtcaccg attaaattga accggaccgg gattttcggc ccgaggtttc caagaaggct 2980681 gttgccggtt acctgtccca gcggaatgtt gatcataatg ttttcactgg cgccgctgtg 2980741 tccggtatgg gtttccatct ctttcaaatg agcctgaagc tgctttgtca cttttgtttt 2980801 cacactgttt acaacctgtg tattaaaatc gattgtcgtt aagtttccgt tttcatcaga 2980861 attcatttga aacatatctt tcatattttc actgtcagac atatagtcct caatcgaatc 2980921 ctggatcacc tctgtcgcta tacgcttcgt ttccatctcg ccgatgtcca ttaaaacagg 2980981 tttgatcgag ccattgatca tccaaaggct gaccgttgtt gacaggataa aaaagacaac 2981041 ggacaggagc atcacgtaac ggaaaggcaa aggtcctctc ttgcgaaaag ggccgcgata 2981101 tcttggcaag aaaatccccc cttacatatc acaatgtatg cttgtaagag gggacatagt 2981161 aatagccggg gccaatttat tttatttcat catttttaaa agcgcttctc tgccgctcat 2981221 gccgactttg atgccaagat cttccgcagc gtacgtgacg gattctaaag gtgcgtctaa 2981281 cagctggtca atggtgcgga caccaactgc gcgtcccgcc acgatgccgc gctcctttaa 2981341 tttttcattc agcagcgcca catcaagcgc gccgcacata atgtatccgt gatcattggc 2981401 gacggccata aaattcgttt tgggaagctt tactgtcaca gctgtaaaag gctgtccttc 2981461 tatcatgatc ggtgtcaggt ttaccacgtc aaccactccc ttcattcatc actttatgat 2981521 gaagggcaca gcttgttgtg ggctgactgc cttattgtgc aagcttccaa gcaagcagat 2981581 cccgcaaaaa ttccggcata aaatattctt tttctgcagc gtcgcgaatc aacggaaaca 2981641 gtttgccgag cgtaaacata tcaagcaccg caacggagta ttgtttatgt ttttcaatat 2981701 cttccccgtt cagtgtgatc cgagtgacgt gggtgatccc gtcatcgagc cgtttcgttt 2981761 ctacctcaac gccggcatac accattttcc ccatcacttc tccgcggaag ccgagtcctt 2981821 tgatccggag ctgctccatt tgttcggaag cggcatggac aatggtttcc ttcagttctt 2981881 ctcccgtcag gcggacagcc accgggttga tcggatgcgg acagatgcgg tgcagatcca 2981941 gctttgtcac aggacctgct tttagcggac cgagaatgac acctgaattg accatactga 2982001 tgtccgtctc gcaccattcc tttaaggcgt atgccaaaag caaaggcagc tctgattctt 2982061 caaaccactt cacctcagca tcttgtgcaa gctctgcaac ggcatcggac agtttctcct 2982121 cggcttcacg ttctttttca ttgagaaacg ctttagtttc tgcggattct cctgtccatt 2982181 ccgccatgtt ctgcacagaa gccgttttgc tgttgatgct tcgctgtacg ctgtccaccg 2982241 tgatttctac acagccgaca taatgcccgt atttctcggc gctggccagc agtaccccat 2982301 taaccacttg tccatcttcg agcaaatgat gggtatgtga ttcgaggatt acatcaatct 2982361 caggcaccgc ttcagccact gcttgatcat caagaatgcc taaatgtgac agcagaacga 2982421 taatatcagc ctgccctttc acttccagaa tggtttcctt tatgctttca agggcatccg 2982481 taactgtcca tcccagcttg tcatatacag gataatacgg cacagttaca cctaagaaag 2982541 caatggacat accgtttttc aatgatttga tatggtaagg caccgcccag gacggacggt 2982601 ttccattttt atcaaacagg ttagagacga tgacaggaaa ttcagcatga tcatataagg 2982661 cagcaagctc ttcatgcgga agcgtaatcc cttcgttatt gccgatcgcc gctccatcaa 2982721 tgtgaaggcg gtttaagaga tcgacattcg cttttccgaa tgtcgcctct gtcacgaatt 2982781 gaaaacgatc aagatgatcg ccaatatcaa aaacgagcgt ctcttcgccg tctgactgat 2982841 gctcttttct tttctgctcg atataatcta caattttcgg ccagttttca aaatggctgt 2982901 gcaaatcatt tgtatgatat aagcggagct tctccttcat aatatctctc cctaatcgtt 2982961 cagctgaaaa tgccttcata aatgagctgg cagccgatca aaatcaatac gatccgcatg 2983021 atcataacga tcgttttcgt ctgcattttt ctgttgatgg cggcgccaag ctttccgccg 2983081 aaccaagcgc cgggcacaag cgcgagggcg tacagccaat tgacgtgccc ggaaatcata 2983141 tgtgaaacag accctgtcat agaagacagg aaaataataa acatggacgt tgccaccgca 2983201 accttcggcg gaaacagaaa taacagcatc atcgccggaa ccatcagtga tccgccgcct 2983261 ataccgaaaa gtccgcctaa aaaaccgaca acaaaggcaa tggcaatacc gacagaggcc 2983321 tgatatgagt acgtataagg ctcaccggca tcatcctgaa atgtccggat aattcctttg 2983381 tgcgctttgt tgattggccg ggctttcgct ttcagcatta aggataatga aatcagaatc 2983441 ataaaaatgc caaaccaaac ggaaaacgag tttgaattga acagctttga cacgtaagcc 2983501 ccgatcatgc tgccgggacc cgaaccgata aagaaaatga gtccgctctt ataatcaact 2983561 gttttatatt taatataagc caaagttgaa gaaaggcccg taaaaataat gaccaaaagc 2983621 gaagttccaa tcgcaacctg cggcgtcaca tcctgaaaca gctgcgtcac tgtgcttaaa 2983681 aacatcagag atggcacaat gacaattccg ccgccaagcc cgatcagact tcctaccgta 2983741 cctgcgatta atcccagtac gaccaaaatc acaaacgaca tcaatcaaaa cctcttttct 2983801 aaaataaatc gagctgtctc ggagcaagtc cgctgtactc gatatcaagc agttcaagca 2983861 tctgcttgcc attatccgca gcgtcaccgc cggaattgtt gttgaacagg acaaaaacat 2983921 ccttacattg ctgctgcaat tcattcaggt gctttttcca atcctccagc tcctgttggt 2983981 tgtagcggta taagtacctg acctcccgcc agtttttccc gccatcaggc ttcatccagc 2984041 cctgcttgtt gcgtccgtga aacctgacga gcgttttgtt ttcatcggtc gcgcgcaaca 2984101 cggtcggaac gctgccttct ccgatttgcg gttcatcaca gacactgtga atccagcctt 2984161 ccgctttcat aaatgaaagc gtctgctcat aaaatggcgg cgagaaccag gaacggtttc 2984221 tgaattcaag cgcgcaagga atatctccca tttggtgctt acaccatctc aaataggcga 2984281 cattctcctt cttgcagtca aaccacggcg gaaattgaaa cagcaccatg gcgagcttat 2984341 tgctatgtaa atatggcgtt aaagacacct taaacgcatc aaacatctcc tcttttgagt 2984401 caaagggaat ttcgccgcgc tgatgccctg tcatgccctg atatgctttc acgataaatt 2984461 ggaaggtttc gggcgtttcc ttcacccact tttcattatt gcgcgccggc tgaatcgcgt 2984521 aaaagctcgc gtctaattcc acgatcggaa aatgggagga ataggcctgc aattttttct 2984581 ggctggccgt tttcggcgga tagatgctgt catgatcccc ccatcccgtc agtccgatat 2984641 aaatcacact cattcacctc tcttccagtt tatcacacgt gttttcaggt ttcctcggaa 2984701 atgctgttca tatggcggga aaatgcctca cgcaaatgct gatattgttc ctcattcgta 2984761 tctaaaaacg cctcttctct tgaggaagga atgtgctgat attcaatagg cgcctgaaac 2984821 tgctcactcg taaaatcgta caccacacca ttgatgctgt tataaaaatg ccagctctca 2984881 tcgactcttg ttttgaaaat cgtgccgccg aaatggtctt gaatcaccaa tgccgtcacg 2984941 ccgcattggc cgcatgacgg gcattcttcc gtccatttag agctcgaatg gcgcgaccag 2985001 gattgcttaa gtatgtattt gacatgctcc attgcctccg cctcctttaa aaaaagatac 2985061 cacgttgatg agattttaaa aactagaacg gaggaaatca aaaaacccgg cggtaaaatc 2985121 cgccgggctt acgaaggaac gaccagagct ccgtcaattt cagtgacttt ttccccatca 2985181 ttgtacacgc accggccttt gctgtaagtg gccgaaatgc tgcagggaaa tgtatgtcct 2985241 tcgtaaatgc tttttttatg ctttgcaaac atcgattctc ttgtaacagt gtacggctcc 2985301 atgctgacga gcacgaaatc tgcatcacac cccgcctcaa gccgcccttt tttctgaagg 2985361 ccgaatcgtt ttgcaggggc cgccgctgtc cattctgcga tggtttcaaa tggaatctga 2985421 tgctcaagcg ccagttccag cattcctaat aaagtgaact gcccgccgct gattccgccc 2985481 catgataaaa acatgttatc ctcccgcttc aaggatggac ggcaagggga atggtctgag 2985541 gaaaccatgt caatgtcccc ggcaatgagc gtctcgatca gcgtctcttt tgattgccgt 2985601 gaccggagcg gaggcgcgca ttttgcgaca gagccccttt gccgtaaatc gtcatggctg 2985661 aacaagacat aatgcggaca tgtttcaacc gaaacatcaa gaccttcctg tttcgcctct 2985721 ctgatcagcc ggaccgcttt cgccgtgctg atatggacaa aatgaaccgg acagcctgtc 2985781 accttcgcat actgaatcgt gcgatacacc gcttcaactt ctgcttcctc cgggcgggag 2985841 gcggcgtacg catccgcatc cacctttcct ttattggcca aaaccatctg caagtagctt 2985901 gtgatcgcgt cgctttccgc gtggagagcg aggatttttc ctgcagccgc gatttctgcc 2985961 atgcctttga gcaatgtccg ttcatcaaca gagcggaact catcagtgcc tgactttgat 2986021 aaaaacgctt taaacccgat cgctcccgct tcagccatcg gacggatgtc ctcgatatgg 2986081 cctggcacaa ggccgcccca tagcgcaaaa tccacggcag atttttgcct gcctagctca 2986141 gcttttgcga gaagatgctc tgccgtcacg gttgatggaa tacagttgag cggcatatca 2986201 aaataggtag tgcaaccgcc tgcggccatc atttgagaac ctgtttcaaa cccctcccaa 2986261 tcctccctgc ccggttcatt aaaatgaaca tggcaatcta tcacaccagg aaacacgtat 2986321 ttcccgtctg cctggatgat ttccgtcccg cttgcttcaa tgtcagaacc tatctcggca 2986381 atgacaccgt tttgaactac aatatcagct tctataacgc catctggcgt aactgccttc 2986441 gcacctttta tcaccatatc gtaagccata ttgatccccc catgtcagga tgacgatttt 2986501 ccatgtcagt ttatgtaaca caaccagttc tattttcaac agtttactgc tactatgatc 2986561 gtattacatc agcaaaaccg ctagaattcc tattgaaaat tattcacctt aaccaatgtt 2986621 tttatagaaa aggagaatgc gctatgaata ttcttgatgt gatgaaaata ccggcttttg 2986681 aaaacgccaa tttaatcgct ggaaaagcag gaggggaaag agaggttcag catgtcaata 2986741 tgatggacgc tccggatatc gtagactttt tgcataagaa tgaattgctc gtcaccaccg 2986801 cctatcacct gaaggatcac ccgcatcaat tatctgaact gattcggcaa atggcaaaac 2986861 gcggctgcgc gggcctcggc attaaaacaa agcgctatct ggaagatatc ccgaaggaaa 2986921 tcatcgaact ggccgattca tatgcgtttc cgatcattga gcttccggaa cacatccgac 2986981 tcggcgatat tgtgaatgcc acactcagcc atattctcga tatgcgttct aacgagctgc 2987041 agcaagccat ttacgcgcac aaaaaattca caaaccacat tatgagcggc aaggggctgc 2987101 aatccctcct caaaaaggtg tcagacatcc ttcagcttcc cgtgctgctg cttgaccagc 2987161 atgccaaaat gctgtctgcg tctcatcaga tttcagttga gaccgaaaag ctgaaaggca 2987221 ccctgaatac cgtatccggg ccatttttca cttgtttctc tacaatctca gatcagaaaa 2987281 catattctgt cctgcctatt tataatcacg aaaaaaactg cggctacctg ctgatacccg 2987341 acatggtgca ggcaggcgac aaaggattga tcctcacgat tgaacaagcg gccaacgtca 2987401 tttcctttga actgctgaag gaaaatgcgc tgaagcagtt cagccggcgg gcccgcaatg 2987461 agtttttcaa caattttatt gagcggacct tttcttcaga tgacgaaatc aaaaaccggg 2987521 cgaaagaatt caagctgcgc tgggatcaaa aatacatgtg catcgccggc aaactcgatc 2987581 gcaatgacga atcaatcagc tttacagaaa atcagctcgc ttccgacagc gtattcgaat 2987641 ttcttgaagg tgaattatca gccttcccgt ttccacctca cttctttatg aaaggaaatg 2987701 tcggcattat tctaatcgag gcgacagaca gctggagtga aatgcacgcc tcggtgatca 2987761 gctttttaga acagtttcaa acacaggtca gcgctcaatt taaacgaacc gtgtcctttg 2987821 gcatcagcaa tatctgccaa aagctcattg atgttcccga cgctttcaca gaagcttctg 2987881 atgctctgca atcggggcat ttgtcaagaa gcaccgcatt tatccaggtg tatcacgcca 2987941 aagatgtgcc tgagcttctg cgcttgctcc cagttgagga tttgaagaaa ttttacaact 2988001 ccacgcttca gagcctcgct gaaaaacagc aggaggatca aagcctgctt catacgcttt 2988061 ccgtctattt agagacacac tgccaaattt cagagacggc aaagcgtctg tacgttcatc 2988121 gcaatacggt catataccgc cttgaaaaat gcgaagagct tctggggaaa agcttaaaag 2988181 atcctgaaac aacgatgcgt ttgcggcttg cattacgtat gcagcggctg atcagctaaa 2988241 gtttgttaca ttttcttaca aaacgaatcg tttttcgtca ctttcagcaa tcacacctgt 2988301 ctttttcagc tactgtatcc aatgacaccc ctcgaccgga acgatattat gttactaaag 2988361 ttcacataca gggagggact atagtgaaaa aaagatcgtt taaggtgttt acacttagcc 2988421 tgcagcatgt gctcgccatg tatgcaggtg cgattttggt gcccctgctt gtcggcaggg 2988481 cgctgaatgt aacaactgaa cagctgtcct acctattggc gattgacctg ttaacatgcg 2988541 gcgtcgctac gcttttgcaa accttgcgcg gaacatacat cggcatcggg cttcccgtca 2988601 tgcttggcag ttcatttgtg gccgtcaccc caatgattgc aatcggcagc aattacggca 2988661 ttcacgcgat ttatggttcc atcattgcgg ccggtgtgtt catctttttg tttgcgcgtt 2988721 ttttcggcaa gctgactgtg ttatttcctc ctgtcgtaac aggtaccgtt gtgaccttga 2988781 tcggcctttc acttgttccg acaggtgtga aaaatatggc tggcggcgaa aaaataaacg 2988841 gcagcgccaa ccccgaatac ggttcgctcg aaaaccttct tctctctgtc ggtgtccttg 2988901 ttctgatctt agtcctcaac cgctttctca aaggatttgc ccgaacactg tccgttctga 2988961 tcggcatcgc cgccggaaca gcggcagcag cgatcatggg caaagtcagc ttttcttctg 2989021 ttacagaagc accgttcttc caaatcccga agccttttta cttcggagcc cctgcgtttg 2989081 aaatcggtcc gatcttaacg atgctgatcg tcggaatcgt cattattgtg gaatcaaccg 2989141 gcgtttttta cgcaatcgga aagatatgcg gcagaccttt aactgacaaa gatctcgtca 2989201 aaggctatcg agcggaagga atcgccattc tcatcggcgg gctgttcaat gcctttcctt 2989261 ataatacctt tgcgcaaaac gccggcttat tgcagctgac caaagtgaaa acaagaaaca 2989321 tcgtcgttac cgcaggctgt atccttgtct gtctcggact gattccgaag attgccgccc 2989381 ttgcatctgc cgttcctgct gctgtacttg gcggcgcgac cgtcgtcatg ttcggcatgg 2989441 tgattgcctc cggcgtcaaa atgctcagca cagcggatct caaaaatcaa taccacctcc 2989501 tgaccatcgc atgctcaatc gcactcggca tcggcgccag cacggccccc gggatttttg 2989561 ctgaattccc cgctccgatc cggattctgg tcagtgacgg caccatcacc ggaagcctaa 2989621 ccgccatctt tttgaatcta tttttcagct tgcgcgacaa aaaagaatta acagcacagc 2989681 aaacagaact tccggtatta gaacatacac tcgcattaga aaaagaggtg taaaaaagat 2989741 gaaggaacag cacaatgcct tacagctaat gatgctgggg cttcagcaca tgcttgccat 2989801 gtatgcggga gccattctcg ttccgttgat cgtcggagca gcgatcgggc tgaatgcggg 2989861 gcagctgacg tatttaatcg cgattgattt gtttatgtgc ggggcggcaa ctcttttgca 2989921 gctctggaga aaccgatatt tcggcatcgg ccttcccgtt gtgctcggat gcacgtttac 2989981 cgcagtcggc ccgatgattt ccatcggaag cacttacggt gtcccagcga tatatggtgc 2990041 cattatcgcc gcaggactga ttgtcgtctt agccgcgggc ttcttcggga agcttgtccg 2990101 tttttttccg cctgtcgtaa ccggatcagt cgtcatgatc atcggcatca gcctgattcc 2990161 aacggcaatg aataacctgg ccggaggtga aggaagcaaa gaattcggct cactcgacaa 2990221 cgtgctcctc gggtttggcg tcacagcttt tatcttattg ctgttttatt tctttaaagg 2990281 ctttatccgc tccatagcga ttttactcgg tcttatcgca ggaacagcgg ctgcatattt 2990341 catgggaaag gtcgattttt ctgaggtttt ggaggcgtct tggcttcatg ttccgtctct 2990401 gttttatttc ggaccgccaa cctttgagct gccggctgtt gtcacgatgc ttctcgttgc 2990461 aattgtcagc ctcgttgaat cgacaggcgt ttattttgcc ctcgctgata tcacaaaccg 2990521 caggctgtcg gagaaggatc tggaaaaagg ctaccgggca gaaggccttg cgattttgct 2990581 gggcggctta tttaacgcgt ttccctatac agctttctcg cagaatgtcg gcatcgttca 2990641 gctctcaaag atgaaaagtg tcaacgtcat cgccatcaca ggaatcatac tggtcgcgat 2990701 cgggctggtt ccaaaagcag cggccctgac aacagtgatc cccaccccag ttctcggcgg 2990761 cgcaatgatc gtcatgttcg gcatggtcat ttcttacggg atcaaaatgc tatccagcgt 2990821 tgaccttgat tcgcaaggca acctgctgat tatcgcctct tccgtcagct tggggcttgg 2990881 cgctacaaca gttcccgcgt tgttttcatc tctttcgggc gcggcctctg tcttggcagg 2990941 aagcggaatt gtgatcggca gtttgacggc cattgcactg cacgcttttt ttcaaaccaa 2991001 acagccgaat agcgcagaca taaaaacgta aaggaagatg ccaatgttca caatggatga 2991061 cctgaaccaa atggacacac aaacactgac agacacactt ggctctattt ttgaacactc 2991121 ttcatggatt gcggagagat ccgcagcact acggccgttt tcgtcccttt ctgatcttca 2991181 ccgcaaaatg actggcattg taaaagctgc ggatcgcgag acacagcttg atttaatcaa 2991241 aaagcatccc cggctcggaa caaagaaaac aatgagcgat gactcggtac gagagcagca 2991301 gaacgcaggg ctcggcaaat tagaacagca ggaatacgag gagtttctca tgctgaatga 2991361 acactattat gatcgcttcg gctttccttt tattttagcg gtgaagggaa agacgaaaca 2991421 ggacattcac caagccctgc tggcaaggct tgagagcgaa cgagaaacgg agttccagca 2991481 ggcccttata gaaatttacc gaatcgcccg ctttcgtctg gctgacatca tcactgaaaa 2991541 aggagagacg caaatgaaaa gaaccatgtc ttatggcaaa ggaaatgtat ttgcataccg 2991601 aacgtattta aaaccgctca ctggagtgaa gcaaatcccg gaatcatctt ttgccggaag 2991661 agataatacc gttgtcggcg ttgatgtgac atgcgaaatt ggcggagaag ccttcctgcc 2991721 atcatttaca gacggagaca acactctcgt cgtggcaacg gattcaatga aaaactttat 2991781 ccagcgccat ctcgcatcct atgaaggaac gacaaccgag gggttcctac actatgtagc 2991841 tcaccgattt ttagatacct attctcatat ggacacgatc actctgactg gcgaagacat 2991901 tccgtttgaa gcaatgcctg catacgagga gaaagagctc agcacaagcc gcctcgtctt 2991961 cagaagatcg cgtaatgaac gaagccgctc tgtgctgaaa gcagaacgaa gcgggaatac 2992021 cataacgatt acagagcaat acagcgaaat catggatctt cagctcgtca aggtgagcgg 2992081 caactccttc gtcggcttca tccgggacga atatacgact ctcccggaag acggcaaccg 2992141 cccgctgttt gtctatttaa acatcagctg gcaatatgaa aatacaaatg actcatacgc 2992201 ttctgatcca gcacgctacg ttgcggctga acaagtccgc gacttagcga gcaccgtttt 2992261 tcacgagctc gaaacccctt caatccaaaa cctaatctat catatcggct gcagaatatt 2992321 agcgaggttc ccgcagctca ctgatgtcag cttccaatct caaaatcaca cgtgggatac 2992381 ggttgtcgaa gaaatcccgg gctcaaaagg aaaagtctac accgaaccgc gcccgccata 2992441 cggtttccaa cattttaccg tgacaagaga agacgccgag aaagaaaaac agaaagccgc 2992501 tgaaaaatgt cggagcctga aagcctgatg ggaaaactga caacccatat tttagattta 2992561 acctgcggca aaccagcggc gaacgtaaaa attggattga agcggctggg cgaaagtatt 2992621 atgaaagagg tatacactaa caatgacggc agggtcgatg tccctctgct ggctggtgaa 2992681 gagctgatgt caggagagta tgtgatggaa tttcatgcag gagactattt tgcgagtaaa 2992741 aacatgaacg cagccgatca gccgttttta accatcgtca ccgtccgttt tcagctagca 2992801 gatccagatg cacattatca tatcccgctc ttgctgtcgc cgtttggtta tcaggtgtat 2992861 agggggagtt aagaaggaag cccgcctcac cggcgggctt ctttttgcac ttcaattaac 2992921 ttttgatcct aggacagtac ttgaagtgat ccccacactt agtgaaacaa cagctagaat 2992981 aaacattcac ctatattttt caggataatt gcctacgaga aaaataccct gtagtccttt 2993041 catttataaa tcgaggtttc aaactaataa gtcagctctt agcagccgag ctcccttctc 2993101 caatcctata aacagaccgc gttttttctc gaaaaaatac tctgaagaca attgctgcgt 2993161 ttttaatagt tttgataacg cgttctctct tacaccttta gacaaaatat tcattttttc 2993221 ttttttagac ttaaatctat gtcgaaaata atcgttggca tatcttatcc tatctccact 2993281 aaaggaggtg acattatggg attctacaat tctggtggat acagtggaaa ctctggttac 2993341 tcaaacggtt tcgggagctc cttcgctttg atcgtggtgc tattcatttt gttgatcatt 2993401 gttggagcag ctatctttaa ttattaagtt taactttcct tgcctccgcc gtatccaaca 2993461 cctccctgtc cgacagacgc cataagaagt ttttatggcg tctttgctat gtgttcacta 2993521 atctttttgt aatccagaag ctgtcaagtt ctacgagatt tatcgtgtgt tttcccacaa 2993581 cgcttctgcg tcttgatcgc gctgtctgac tgaggctaaa aaagtccggc ttttaaaagc 2993641 cggactcccg tctacccccg ttcaactctc ttctaatcct gcaagctgac cgcataatcc 2993701 cgccataccc ggtacaccgg cacaaattcc ccgccagccc ttcttctata tctttgtcag 2993761 aaggttgagg ggtttcccga aacaatgctt taagcgcaat gatcattccc ggcgtacagt 2993821 agccgcattg gaagccgcct tcttccagga aagcggtttg acacatatcc agctcttctt 2993881 tttgaagccc ctcgatggtt gtgatggaat ggccgtctgc ttgataggcc atcgtcatgc 2993941 acgcattggc cagttttccg tcgattaaaa tagagcaggc tccgcagcgg ccgattccgc 2994001 aggacacctt tgtcccggtc agctgaaatt cctttctaag caggtcactc agatgtgtcg 2994061 taggaacggc agcaacctcc cacgcctgac cattcacggt catccggaac tgttcctttt 2994121 ttacaggaaa tggcccggcc tcttttatgt ccattgcttc agcccctttc tgtcgatcgc 2994181 ttcaagcaac tcttctcttg aaattggcag cttgtttatc cagcatccga ccgcatcatg 2994241 tactgccttt acaatcgccg gagtgatggc gattgttccg atttcaccaa caccgcgcgg 2994301 tccatatacg tctcccttca ttaagtcttc tattgcaatc agcttcatgt caggaacatc 2994361 tttgattccg ggaatcaaat agtgatcgag attttccgca gcataacggc catccgtcat 2994421 tttcgcttcc tccatcagtg tgtagccgag tgccatggca gcgccgcctt caatttgacc 2994481 tcgatatccc tgcggactga caaccggacc tgccgcaata gcgtgctcac aatctatcaa 2994541 tttgacatcg cctgttaaca gatctacctc cacctcaacg gcagccgctc caaatgagta 2994601 gaggaaatgg ccgcccacca caggatcagg cgttgttgga aagtcaaagg ccgtttcctc 2994661 tgccaaaggg cctttttcag ccagctcctt atacgtcacc acgagcgcct ttgtgttttt 2994721 gtcacgcaag cctgcagcgc cgggaataag attttccgct gaacagccgc tccattctgc 2994781 cgcccgtttt ttcaactgag ctagaaacgg cttcttcaaa cgctggatcg cgtgccacac 2994841 catgcttgtg ccgcgggatg ctgtggagga gcctgacttc ggcacttttg cggtatcccc 2994901 aataacaatg gaaatatcct ctgcggcaca acccagctcc tccatgacaa tctgttcaat 2994961 cgctgctaga atcccctgtc cgcattcttc aaatccaaac gaagcagtga ttttgccttc 2995021 actcgaaaga gacaaacggc ctcctgccgc atccattcgg ccaaacccca gcccgccgcc 2995081 gtgcattgta attgccgctc ccgtgcctct ttgcagatac ccgcagttcc ggcttgtttt 2995141 tttaagaatg ggagatttag atatggcatt caacacctgt gccgctccgt cagttggtgc 2995201 aattcgatgc tcaagcggcc ccaagtcatg cggttttctg atattttttc ttctcagctc 2995261 gagcgggtcg atgccaagca tgccgctgag acgatcgaga tgggtttcga gtgcaaatgt 2995321 gatttggttg ccgccaaagc cccgaaattc ccccgccacc ccgttgttcg taaatactga 2995381 tattccttca gtccggatat tcggaatacg gtacggcccc gcggcatgct cgacagaaaa 2995441 atcaagaaca gccggtccga gcgtagcgta agcgcctgtg tccgccacaa ttttcacgtc 2995501 gtgcgccaat agatttcccg aatgatctgc acccgttttt atcgtaatct tcatcggatg 2995561 gcgcttaatg ccagaacgta cagattcctt tcgtgtctga tgaattttga cagggcgtcc 2995621 gcttttcagg gccaaaagcg cagcatacgg ctgaatattc agctcatcct tccctccgaa 2995681 cgagccgccc atcggacttg acacaattct gatcttctct tcaggaatat caaaaatacg 2995741 ggcaagctgg aaacggtctt tatagccgtg ctgggttcct gcatacatcg taaaaccccc 2995801 gtcgtcttcc ggaacggcta cacctccctc cgtttccata tacgtatgca tctgccgcgg 2995861 cagctcatag gtttcttcaa agactgtgtc agatgcttga aacccttctt ccacatcacc 2995921 gtttgaaaaa aatgcgcggt gcaggatatt cccgtcctca tgcagtcttt gcgcattcgg 2995981 ccgaagcgct ttttctggtg aatccatgac ttccagctct ttatactcaa cttgaatcag 2996041 ctccagcgcc gcttccgcga tttcttccgt ttccgcagca actgcggcga tcgcatcccc 2996101 gacataccgc accctgtcct cacataaaac cggctgatca gggatgacaa tgccaaatcg 2996161 gtttaagccg ggaacgtctt tatgtgtgac gacggcctgc acgccttcca ttttctcagc 2996221 ttttatggtg caaaccgaca caatctctgc atgaggataa gcacttctca gcaccttgcc 2996281 atacagcatt cctggaaagc tgagatcggt catatatttc aattcccctg tgaccttacc 2996341 ccttccatcc ggcctgactc ttgacggttt gttgatgatc atttattccc ctccctcagc 2996401 catcagctct gccatgatga cgttggcagc ggcttttttt ctgtatgccg ctgacataaa 2996461 aacatctgag gaaaacggca gctcatggat aagtgttttg tacagctcat gcgggtccca 2996521 ccctggtgcc atccatttcg cttcgctgtc caataatctc ctaggagtga tatcggcatg 2996581 gccagcggcg aggcgaatgc tgccgtcttt caaaaaacgt ccagctgcaa cagcagccgc 2996641 tccggtaaaa gcctggcgcc ttccaagctt gtgataaaat acacgctctc cctccgcccg 2996701 cgggatgatg acacgcgtga cgatagccgt tctaaagtct tcctcactga gccaagcgcc 2996761 aagcggcagc ctgattagct ccttttgata tacgataagc tcagcaccaa gcacaagcag 2996821 aagcggaatg aaatcaccga ttttactcgc tatgttgccg ccaatcgtgg cacggctgcg 2996881 aatccccggt gcagcgacag cggaagcagc gtcactgaaa cagctaagcg ctctcttaat 2996941 caaagggttc tttctgcatt cattcagtga tgtgagcccc ccgatcgaca cgtgggtgtc 2997001 actggtgctg atccctcgca tttcgtcaat cccttcaagg ctgacaaggt gctgtttcgg 2997061 tagagttcct ttgtcccact gaagctgaag gagcgtgctt cccgatgcgg cacacacatc 2997121 cggagcaagc ttctctaaaa gcgaataggc ctcatcaagc gctgccggtc tccataattg 2997181 aatattcatc cttgcttttg tcacttggcc gttcaagaca tcgccctcct taccatgtca 2997241 tattcctcgg gtgtatcaat atcgtccaac tcaccgctat cctttgcctc caaaaccgct 2997301 cctgctccaa gctgtccgct tttcaggagc ctgcgagccc cttcatctcc ctttaatccc 2997361 tttacataag gaaaacatgt cgacgagaag tagattggcg gggtgaacgc ccctaaaaac 2997421 gatgacacgg caaatgactc aggagccaga gccacaaggg cattgagatg atcgacggaa 2997481 agctgaggct ggtcggctaa caaaatgaca atgccgtccg cccccatgct ttctgctttt 2997541 ctcaccccgc tgctgactga atgcccctga cccttttctg cgtcttggca aacgtgcagg 2997601 ctccagcgtt tttgaaaagg cggagcgtga tacggcgctc ctatccactc aagggaggca 2997661 tgttctgtcc gctcgacgac cagcacgtga tcaaggcggg acgacagagc agttttcaag 2997721 gaaagtgagc ctatgttttc tccttttagc ggcaaagcca gcttgttttg tcccattctt 2997781 ctgcttttgc cggcagcgag aaacacgccg atcagatagg ggcttctcat acaaccgcca 2997841 cccgttttct tgtttgaatg atttctgcaa ctacacttac cgcaatttcc tcgggacctt 2997901 ccgcaccgat tttcagcccg accggactgt aaaagtgaga cggaggatgt tttccgctca 2997961 gcagccgttt cgtgcggttt gccgaaccca acagtccaat ataatggagg ttttgagaaa 2998021 ataagaagtt gatgatcgtt tgatcgtgct gataatgatg ggttgccaca acagctgcat 2998081 catgcggaaa aaattgaaat tcgctaagca tttgttccgg aaaagcggtg atcagctgat 2998141 ccgcttttgg aaaaagagag gatgtacaat aagcgggccg ccaatccgtc acgataacag 2998201 aaaaccctgt gtcagccgcc aaattggcca gcggtacatt atccggtccc gccccaaaca 2998261 gaatgagacg cggcttcggt tcaattcgct gaataaacat gttagtggtt tgatcgaaat 2998321 gcggtaaatg aagcgttgaa acagtacgtt gaatatcttg cagaggcgcg tccggccagt 2998381 tcccaaaatg tccgttctcc gtcagaaata aataatggga ggattcaatc tttataacgg 2998441 aagtgacagc tttgcctgaa tgaaggcagt ccctcacttt ctcatagtgc cgcctttttt 2998501 cctgagtgat tcgctctgca tgaacatgaa taatgccatt gcacccggct cccatgcccc 2998561 aagaaagatc gtcctccgac cgcatgtcgt agggaatcag cgttgatgtg agctgatcgc 2998621 ccagcgcact gattctttgg aatacatctt cttccacaca cccgccgctc agcaagccaa 2998681 tccgtctgcc ttttttctta aagagcatag aggcgcctgc ttttcgatac gcggagcctt 2998741 caacttgaac aattgtcgcc agtacagcct cctcctggtc ttccaggagc gcatctaaca 2998801 tcgtgtgaaa attccccaat gccgcatcct cctctcgaaa attgccgtga gaaacaacta 2998861 gttcagcgtg attttatagg taacttgtat aaagaataga cgatggaaga aaaaatgact 2998921 catgatttgt cagaaaatga aacacataga aagaggattt gtaaaaagag tcaaacgaag 2998981 aaaatcagat tggagaaaac acgaaatcat atcgttaaaa agcttgcgga gttccgcaag 2999041 cttttcttta caccgctgcc tggcggccag cgttttcata cacatccagc gctgcttgga 2999101 gcgcttttcc tgcttcgatt cctgcgttat gtctgagaag cacagcctct aacccggcaa 2999161 gcacgaatag cacgttttct tttctgcagc tgtaccccat cgtgccgatc ctccagatct 2999221 tccctgcaag cgggccgaat gagctggcga tttcaatgcc gaattgtgcc agcagcatgt 2999281 cacggacaga ctcgccgtca atgccgccgg gaatttcgac acaggtgaca acaggcattt 2999341 tgcagctgtc atctccaaac aatcttagcc ccattgcctt tatccctgct gctaatgcgg 2999401 cttcatggtg ccgatgccgc tcgaaacgcg tctcaagacc ttcttcaagc accagtctga 2999461 ctccctcacg taaggcgtac agcatcgtcg tcgcttctgt atgatgattg agccgtcttt 2999521 cgctccaata atcctcaagc tggctcaaat caaagtagtt gcttgtaatt ggccgatttc 2999581 ccgaaagtgc tgccctgtca gcttgtgtcg caatcccgcg ttccaccttt ttgcgagctg 2999641 caatcacgtc cgccacccgc tcattatatg taatcggcgc cattcctgaa ggcacagaca 2999701 aacatttttg cgttccgccg atggcagcgt caatcttcca ttcatcgact ttaacctcgc 2999761 agcccccaat cgttgcgact gcatcgacga taaacaatgc atcctcggtg cggcaggctt 2999821 cgccgatggc tttcagcggg tgaatccgtc ctgtcgatgt ttctccatgc accatggcca 2999881 caattttcgg cttcactttt tttatctccc gtatgatgtc ctccgggtca aaaaccgttc 2999941 cccattcgca ctccagcata tgaacatttg ccccatatcg ctcggcgatt tcagtcagca 3000001 aataaccgaa acggccgtaa atgggaatga gcacatcatc ttccggctct atcacactag 3000061 ccagcactgc ttcaattccc gcccgtgaag tgccgtcaat cgggtatgcc cagcggtttt 3000121 ttgtttggaa cagctcccga agcatctcca tcgtttcatt cataatacct gtaaacgccg 3000181 gatcaaattg gccgacaacc ggggtgctca ttactcttaa tacacgcgga tcaacctcaa 3000241 caggccccgg tgtcataatc gttcttaacg gggtgcataa ttctcttctg cctgacacag 3000301 ccattcctcc tttatcagta agccagtttg tataataaat cagtcagtgc gcggacgccg 3000361 atctcaagct gtctggctga cgtatattcc ttcggtgagt ggctgacgcc gcctcggctc 3000421 ggcacaaaca gcatacaagc aggatagcgc cttccgatca tttgcgcgtc atgccctgct 3000481 ccgctcacca tttcctcaca gctgaagccg ttttctaatg ctgtttcaaa agccgcagcc 3000541 ttcagccttt cgtccatcgg cacaggctct atccgcatat attcatcaat cacagcgcga 3000601 attccttttt gtaggcaaat gccgttgatc aaagcaacca tgtcttgatg aaactgttcc 3000661 agcacatgct gatgctgatg gcgaatatcg attgaaaact ggacgcggcc cggtatgaca 3000721 ttggctacat tgggctctgc cgttattttt ccgcatgtca gacggagctc atccggcagc 3000781 tcatccgacc gcagcagcag ctcatgaatg atacggctgc tggctgcgag cgggtccttg 3000841 cgccatttca tggaggtggt tcctgcgtga ttgcattctc cttcgagcgt gacgagatat 3000901 cgtctctgcc ccgcaatact tgtcacgatg ccgagatccc ggcctgacat ttccaacgtc 3000961 ttcccctgtt caatatgcag ctcaacaaac gcgctgatat ctgtcctata tgctgactga 3001021 aacacacctt tgccaaaacc gctctcatgc atcgctgttt ggagggagac tcccgactcg 3001081 tctcttggct cttttgcatc ttgttctgaa aaaacacccg tcatattccc cgacccccaa 3001141 taggtcattg gaaaacggct gccttcctcc tcacataagg agaccgcctc gagcgttttt 3001201 tttggcgctc cgtatgtttc cttgagctgc tttaacgcga gcattgccgc cagaacgcca 3001261 taggcgccgt cgtattttcc tccattgatg acagtatcga tatgtgaacc ggttacaatg 3001321 acttcatccg gagactgggt gcccgaaagc cttccaaaca cattgccgac atcgtcgaat 3001381 cttgtttcaa gcccgaaaga agacatttcc gttttcacag caagctgtgc gtccatccac 3001441 tcttttgtgt ataaaagcct cgttacgccg ccatccgcag acgcaccgta ttgggcgagc 3001501 cattcaatat aatctgtgat gctgtttttt actgaaagct tctgcttttc catgtactcc 3001561 cccctctggc cgctatggtg acttcattat agaaggagca acatgatagt tcattgacag 3001621 attaaccaaa aaaacgttta ttttttagcc acagtatcca tccagcaacc agatacaccc 3001681 tacatgtcac aactattttg atgtaaaggt caaaagaaaa cacggtaagg aagagagcca 3001741 gcaagagcga aagagagggt caaaatgcct ttcatatgaa caagctaagc tggagaggcg 3001801 atgttcgcgg aacggatgaa aacagaaatg ccggcagccc gcaaaaacag gacctaaaga 3001861 tatggaaaca ggagatttcc gcctcctcca aagggactaa tttacaattt taatgaaaaa 3001921 tatacaaaat gacacttcta tcctttattt caattttaga taatagatat gatctgataa 3001981 aaggagggca agtgatgaca aaaaaagcat ggtttctgcc gctcgtctgt gtattactga 3002041 tttccggatg gcttgcgcca gcagcttcag caagcgcgca aaccacatta agccttaatg 3002101 accgattggc gtcttcccct tcaggaacgg gaagccttct ctcattagcc gcccccgctg 3002161 caccctatgc tgacacagat acctattatg aaggggctga aggtaaaaca ggagactcgc 3002221 taaaaagcac cctgcaccgt attatcagcg gacacacgat gctgtcctac agcgaagtgt 3002281 ggaacgcgct gaaagaaacg gatgaagacc caagaaatcc gaataacgtc atcctgctct 3002341 atacgaatga atcgcgttcc aaaaacctga acggcggcaa tgtcggcgat tggaaccgcg 3002401 agcatgtctg ggcgaaatcc catggcgatt ttggtacgag caagggacct ggtactgata 3002461 ttcatcattt gcgcccggct gatgttcaag ttaacagcgc cagaggaaat atggattttg 3002521 acaatggcgg cactgaatat gcgaaggcac ccggaaatta ttatgacggc gattcatggg 3002581 agccccgcga tgatgtgaaa ggcgatgttg cccgcatgct gttttacatg gctgtccgtt 3002641 acgagggtga tgacggctat cctgatcttg agcttaatga taagacaggc aacggctcag 3002701 ctccttatca tggcaaacaa tctgtcctgc tcgaatggaa taagcaggat ccggttgacg 3002761 accgcgagcg gaaaagaaat gaaatcattt atgaaaaata tcagcacaac cgcaatccat 3002821 ttatcgacca ccctgaatgg gcggatgaga tttggccgta agaaaaaggt gctccttttg 3002881 aggagcacct ttttctaata cacagcctct tccgtttccg catcgaaaaa gacgacgtgg 3002941 tccattttca ctgagagctg gattgaatcg cctgcatcga ttcgcgtgtt tccgtccagg 3003001 cggaccttga gccgctcgtc cccagccatg acatgcacta tgagctccga gcccagattt 3003061 tcattcactt ccacgttcgc ttgaaacact gaatcaaaca actggtcatt tcctgtcatt 3003121 tgtgtgatgt gctccggccg tacaccggca atcatctgtt ctccggcata tcccttttcc 3003181 ttcagccgct ttgctttttc ttcaggaata tgaagccgga tcgaagaatt tgtgaaaaac 3003241 agctcgccat gctgctgttc tatgatgcct ttcaaaaagt tcattccggg agagccaatg 3003301 aagcctgcga caaacaaatt ggccgggtaa tgataaatgt catgaggttt cgccacttgc 3003361 tgaatttccc cttcattcat gacgacaatc cgatctccca ttgtcattgc ttcggtctgg 3003421 tcatgcgtga cataaatgat cgttgcctct aatcgctggt gcagcttgct gatttctgtc 3003481 cgcatcgtca ctcttagttt tgcatccaga ttagaaagcg gctcgtccat taaaaagacc 3003541 ttcggctccc tcacaatcga cctgccaagc gccacccttt gccgctgccc gccggagagc 3003601 gccttcggtt ttctcttcag caaatgttca atttctaaaa ttctggctgc cgcatgaacc 3003661 cgctcggcaa tttcctgttt cgccatcttt ctgagcttta atccaaacgc catattatca 3003721 aaaaccgtca tatgcggata aagcgcatag ttctggaata ccatcgcaat atcacgttct 3003781 ttcggcggaa gatcattgac ccgctcccca tcaataagaa gatttccttc agaaatgctt 3003841 tctaatccag ccaccatccg cagcgttgtt gattttccgc atcctgacgg ccccaccagc 3003901 accaaaagct ccttatcctt tacatctaaa tcaaagtcct tcacggttaa ttgtgagtga 3003961 tatgattttt tgacgtgttc aaatgttaat gaagccatca gaaaagtccc cctatctttt 3004021 gacccgttat ttcgtcactg gaaacaactt ggtctttctg ttatttttag agtaatcgat 3004081 tcccattttt gctatatttc taaaataaaa aatgtaaatt tgtattataa cgtcataata 3004141 cattataata taaataatag gttaaaagga ggctaccctt tgttaaacaa cggaagttct 3004201 acacctttat acattcagct aaaacaaatc atcactgatg acatcaaaaa gggcgtgtat 3004261 tccccaaccg ccaagctgcc taccgaaaac gagctttgca ccaagtataa cgtcagccgc 3004321 atcaccgtca ggaaagccat tctcgattta gtcgaagaag gctatctgat caggcagcag 3004381 ggaaagggaa cgttcgttaa aagccctaaa ttaaaacgag agctgatcgc tgtaaacggc 3004441 tactcggaat ttatggaatc aaccggcaaa aaaccgaagc atcatgtgct gtcccatgac 3004501 atcattccag cgtcaaaacc catcgccgaa aagcttcaaa tccaacccga gagccctgtg 3004561 gttgaattaa aacggatttt atataatgat gatcagcctc tcacctttga agtgacgcat 3004621 tatccgcttg atttgtttcc cggcattgat acctttattg ctgacggcgt ctccatgcat 3004681 gatattttga aacagcaata caaagttgta cccacgcaca atacgaagct attaaacgtt 3004741 gtatatgccc aacaggagga aagcaaatac ctggattgtg atatcgggga tgcgctgttt 3004801 gaaattgata aaacggcttt tacatcaaac gaccagccaa tctattgctc attgtttttg 3004861 atgcacacaa accgtgtcac ttttaccatc aacagcccct acacataaca ggcataaaaa 3004921 acgagacact gcttatagta ttctcgtttt ttcactgctt cccccgtcct ccaagcgata 3004981 aggatagcca tagccgaaag ctccgtacac accgcaagtt ttcgcagccg tttcagcagc 3005041 ctggcgcaaa gcatacgtta tatcctgctt cacgcaaaag gcagtcaaaa agcctgctat 3005101 aaaagaatct cccgctccaa gtgtatctat tatatcagct tccacaatcg gctgatgata 3005161 gactcgatca cccgcagaca ggattgctcc ttggccccct cgggtcatac aaaccatttt 3005221 ggctccgtac ccatgagctg ttttggcaag ctcaccgcat tccgactcac tcaaatcgct 3005281 tcctgaaaaa aacgcatacg tcacataagg acagaccctc ctcaaataat catcctcccg 3005341 attggttgaa aaatcaaatg agaccgggac cagcccgcac agctgcggaa gatcgttctc 3005401 aagcctgctg tacacgctcg tatgcagcag atcatgcccg ctgataaaag atacatcttt 3005461 ctcctgaaac gcgaggcgaa gccgggactg aatgccgcct ttatttgatc tgacaaaaat 3005521 gcggtccccc tgttcatcaa gggtgacaat cgccatcccg ttttctccgt gcgcctggcg 3005581 gatataatct gcattgacct gctccagctt gagaacgttc aacagatgcg ccgcggcttc 3005641 gtcattgccg acgattccga tataggaaga ctcatgcccg agccgcttgg caagcacagc 3005701 aacgtttaag gcatttcctc ccgggtaaaa tgtttcttga tcctggtagt aatctacaac 3005761 attatctcca accgcaatca atttcatagc gcttcctcct ttatcctttt acactgccgc 3005821 ttgcaatccc gcggacaaaa tatttctgca tcaataaaaa tagaataata atcggcgcgg 3005881 ctgaaatcgt taaccccgcc agcaggacgc cccagtctgt ctgcagcgcg tctctgaact 3005941 gcatcagccc ggctggaatg gtccgtaaat tctcatcatc tatgaaaata atcgcaaaca 3006001 taaactcatt ccatgtatgg taagccgtca aaatgccgga tgtcaccaaa atcggcacgc 3006061 tcattggtaa gaaaattctg aaaaatactc caaaacttgt acacccatcc aaataggccg 3006121 cctcctccaa ttcttttgaa atagaaagaa aataagagcg gatcaaaatg atggtgaatg 3006181 ggatccgata agccgcatac ggcaagatta acgcccaata cgtattgtac aggcccagcg 3006241 actgaataat agaataaagc ggcacaagac tgacctgcgg cgtcagcatc aatccgccaa 3006301 gacatagcac caaaaagaat ccttttcctt taaactcaaa ccgggaaagg ccatacgctg 3006361 cccatgcact gataaagaca gtgatcacac acgtcagcgc cgtaacgatg acactgttca 3006421 taaaataaga agaaatcccc tgattccagg cggaaacaaa attttccgga tgccacgaag 3006481 acggcagcga ccagctgtgc tcaaaaatat cgtcagagtt tttaaaggcg ctcatcacca 3006541 tccagagaag cggataggca atcgcaatca gataaagaaa cagaaaaacc cacacagacg 3006601 tttctccgat ataccatttt cgtctaggct tatctttcac ctcaatgtgc tggtcaggca 3006661 ccggctccaa tctgaacgaa tctgtcttct tctgaggcag catcagttac tcctcctttc 3006721 cggttttaaa gaacttcatt tgcatgagcg ataatgcaag cgtaatgatt aacacgacag 3006781 tggcaatcgc tgaggcgtag cccatcatat cctttgtaaa ggcgctttta tataaaaacg 3006841 tgctcaagac ttctgacgct tttcccggcc cgccgcctgt caaaatgtac ggctcattaa 3006901 agaccgtaaa ggctccggtc agcgtcatga ccaccgcaac aaaagacatc tctttcgtct 3006961 ggggaacagt aatatgaaaa aactgctgaa ttttacccgc gccgtcaagc cgggccgctt 3007021 catacagttc atccggtatt ttttgaatcg acacgatgta cagcatcgca atataaccga 3007081 cagattgcca ctgggacaca aaaatgacag aaagcatagc tgtgctgtca tccccgagcc 3007141 aggccctcgt cagctgatca agaccgatgg cctgaagcag ctgattcaaa agccctgtct 3007201 ccggattgta aataaaatca aacaaaagcg cgatcaccgt cattgagatg acaaccggca 3007261 aaaagaaaac ggtacgaaaa aacggcgacc attttctgac cagcttatcc tcaagcaccg 3007321 ccgccaaaat caaaccgcca aatacctggc atacaattga gatcactgca taaagcacat 3007381 tattggtaag tgcctgatag aagacaggat catgaaataa ttcaacatag ttttttaagc 3007441 cgataaacgt tttttccgga gaaaatgagc tccactgaaa caggctgagg aatacattct 3007501 caaaaatcgg gatataaacg aaaagtaaaa aaacgagagc gggcaccaaa aacaaatagg 3007561 ggattatttt attctgattg accaagggta tctcatctcc tttataaaaa gaaaaggtgc 3007621 gaagcttcac cttttctttg atttattcag ctgacgccct cacctgcttt gctgcctttt 3007681 gaacggcttt catcacctgc tgcggtgtca tgtcgccgcc aagcatttgc tggacgcccg 3007741 ttaggtacgc atctgcgact tcaacatcga catccatatc aaaccatgga accattgatt 3007801 tggcatcaac aatatgctga acggcttcac gctgaatggc tgttgcattt tcttcagtag 3007861 ccgtaccttg cactgcactg tatttcccga catctttcac gagcttttcg cccattcttt 3007921 tcgacgtcaa gaactgcaaa aattccatcg cttccttcgg atgttttgtt cttgaggaga 3007981 tcatgaatcc ttccggcgct cccgttaacg cttctgaaga tcctttctgc ccgctgattt 3008041 caggaaatgg gaacatcccg agattaaccg gttcaaccag cttgatttcc gctgtttccg 3008101 catatatcat cgccgacttt ccgctcttaa attgctgtct cacatattcg tggtcgacgg 3008161 agtttacatg tttattaaag taaggcatca gctcttgaag cttttcaagt gcttttacgt 3008221 agccttcatc agtaaattca cccgttttgg cgttatagtc cttttcccgt gttttttcat 3008281 cgaccatccg ctgattaagc gtgccgatat agtgcgagat tgtccaagtc gcctttgttc 3008341 caaagctgat cggtgtgtag ccatgttctt tcagcttttt tgacacatcg attaattcat 3008401 cccacgtctt cgggggatca agattcagct tttggaaaat gtctttatta tagaagaatg 3008461 atttagcgtc catttgccac ggtacgccat attgcttgtt ttcataagta aatggtgtaa 3008521 tttgcgattg aacgagctgt gatgaccaat cggtgtcatt tttgtagtag gacgagagat 3008581 caagtgcttt attgcctctg ataaatttaa aagcaaactc atcgctccaa gagaagtaaa 3008641 tgtcaggagg gctggtggtt cccagcatga ccttaatttt atctttatag gagtcattta 3008701 aaacggcttc aatttgaatg tcgatatctg ggtgatcttt ttcaaattcc ttaacaacct 3008761 cttcaaaata acttttttcc ggctcctttg gccatctgtg gaaaaatttc aatgtcacct 3008821 ttccgtccgc tgaactgctt tggctcgaac agcctgcgat ggtgagcata ctgacagctg 3008881 caatgatcaa gaacaacaac attttcttca aagggttggc ctcctctgga cattagacta 3008941 taatgttata taacattata gtctaatgca taatggttct tcattttcag atcaatactc 3009001 aactttccac atgtatcttc tatgagataa aggatgattt ctctcctctg ccagctcgtc 3009061 tgcatagctt ctcagcacac gattgagaac gagcggagca agatagcctt taactgaatc 3009121 gtcaattgca gtgaagtcgt aagatgcagc atcaagcaca gtgagctttt tgccatactt 3009181 tttcgagaag gtaagcgccc gctcttcaag aggtcttgtt tcatctaaac cgagcaggat 3009241 gataaacggc acggattcat caataatttc aaacggtccg tgaaaatatt ctccggcatg 3009301 aatggcgtgg gaatgaatcc attgcatttc catgagaatg cagatgctgt aggagtaagc 3009361 gacaccgtag tttgcaccgc ttgccatggt ataaataatg ctttcttttt catgggcttt 3009421 tgcaaattgc ttggcgttgt cagcttcctg cttaagggct ttttcatata cagcctgcaa 3009481 ttgatctaag ccttcaattg cttgctcaaa tttcgtattg ttttctaata cttgcagggt 3009541 tccaaaaacg atttgataca aaacgccata gtttgtattg atcgcaagcg cctcatcacc 3009601 ccaatcgtac tgggcaacat attgcgcttc ctgcgctaaa ggagactccg gtttaaacgt 3009661 catcgcaatc gtaagtgcgc ccttgcccct tgcaaacgca gcagctttga ctgtctccgg 3009721 ggtatttccc gaatgcgagc acaaaataac aagagacttt tcaccaagct gaacagggtt 3009781 gcgctgaata aattcgttgg cgctgtagag atcggagttt attgattttg actctctgtc 3009841 aaacacatac ttactcggat acataatggc agaagaccct ccgcatgcga caaagaatac 3009901 atgatcaatg gttttccctt tcaaatcctg caagaaagct tgaacctcac gatttacttt 3009961 tgctgtggcc tgactcaaat ccttcactcc tcgtttttat tatataacgt tatataacat 3010021 tatatattgt tatattaaag tccgcgggta ggattgtcaa tattattttc tgaaatttct 3010081 caataattta ttcggatgac agacaaaggg tctatatgcg aaaaaatgcc caaatcaaaa 3010141 gccagaactt gacttaagct ctggcttcgc tgttcaatcc gcagactgac gtcttattta 3010201 aaaaatacct tgtctatatt gtacttcgag tgctgtgtat tgatgatata tgtttcgtaa 3010261 atctctcttt ccattggatc atcaactaca catacctcaa ttttataaac ttcatctctg 3010321 tgatgtttga tcggtgaaac agtgtcttcg aaatgcttct taattctctg tcttaacttt 3010381 ctggctttac cgacaaacag cagctcgtca tgaatgttgt aaaacataaa aatgccgcct 3010441 ttgtcccttg ggatctggtg aaagtcgatg aatccgtgaa tcggttttat cttcggctcg 3010501 ttatcattag ctgactgctg tcgttcagtg atggtgacat tcggtgcggg tatatcaatt 3010561 tttatcaaaa tcagttcacg tcctcttttt cattaaagat aaatgctaac acatacagaa 3010621 aagaaaagct agaacagctt tattatattt gtttgtcatg ctcttactta ttatgcaagt 3010681 gctccggctg gatcataagg actaaggtct aattctgtct gctttccgag aactagcttt 3010741 gcgagctctg cacccaaaaa cggccccatc gtcagtccag aagcacccaa accgtttgca 3010801 gcgtacaggc cttgaacatt cggcacggcc cctacgaccg gcagaaatcc cggtgtaaac 3010861 ggcctgaagc ccactcttgt ttcaacagca gccgcatcag caagacccgg tgcaacggct 3010921 aacgctttgc tcaatacttc gtgctggcct ccggctgtca cacgaagatc atcaagaccg 3010981 gcatcgtttt cgtgtgtggc gccggctaca attctgccgt tatcaaacga cagaatgtac 3011041 tgatcactcg gcggcattac aaccggccac gatcctgtat ctgcatctgt catttcaaaa 3011101 tgcataatct gcgctttttg aaatgacact tgaaaatgaa tgccaagagg cttcaatatc 3011161 tcattggccc atgctcccgc cgtcacaatg accgcgtcag ccgcaaactg ctttgtatct 3011221 gtttgcacgc cggtgactgt tccgttttca aaaagcaagg acgcatttcc tttgatgacc 3011281 gttgcgccgc gtttctctgc agcgcttaaa agcgaccggc acagcgctct tccgttcaca 3011341 cgggcggcac cgctgatatg aaccgattca tagccgtcag ctaaaatcgg aaacagcttt 3011401 ttcgtttcac ttgcagacaa gcgggtaatg tcgccgattt ccggcgcatc ctcccgtctc 3011461 ttatacgccc tttcctccat tttatcgagt ttagacgcgt cagtatgaat gctgatggca 3011521 ccgacacgtt tgtatcctgt atccgattca ccgtcttttt ccaattgatg gattaaatcc 3011581 ttatagtacc gcgctccccc cttagcaagc tggtaccaat cctgattacg gcgctgcgag 3011641 agccaaggac agacgatccc cgccgccgca tcagtcgctt gtcccggctc tttccgatca 3011701 atgacagtaa cgcgagcgcc tgtttttgcg agatgataag ccgtcgacgc gcccagaatc 3011761 cctgcgccga cgatgatgta cgatttcata tgcaaacacc ttttctatta taatgtctat 3011821 tcattttacc aaatcaaatg ctttccttcg accttttgcc ctaatgtgga aaaaccgcga 3011881 agttcgtcca atctctttac tctcctatcg aatatcctgt cactatcaat agagaaagga 3011941 tgataccatg agcgaaaatc gtcatgaaaa tgaagaaaac agacgcgatg cggcagtggc 3012001 aaaagtccaa aacagcggta atgcaaaagt cgtggtcagc gtgaacacag atcaggatca 3012061 ggcacaggcg cagtcacaag acggagaaga ctaatgaacg aaaacatcat tcctcttaac 3012121 agacatactc aagagatacc cactactgaa tctgttatca aaaacagcgg caactcagag 3012181 gtccatatcg acattcacat tgatacaatg ccaattgctt ttgctatatt atgctctgca 3012241 ttagccgcaa agcagatgac aaaagaggaa ttcgatatgg cttatactca attgcgagag 3012301 atgaacagag aaaataacag cagatcatct gtaaagcaaa ttatcaatca agagacagaa 3012361 gaagagtaaa aaaccgcggc ccctcggcca gcggtttttc ttctgcatac aaaaaggacg 3012421 cgactgaatc ggttacttct gtacaatttg aataaggtta ccgcatgtat cgtcgaagac 3012481 agctattgtg acttcgccca tttttgtcgg ttccgtcgta aacgtcacgc ctttttcctt 3012541 taatcggttg tactcttttt gaatatctgc aacgccaaac attgtggccg ggaggccttc 3012601 ggagaatatc ttcttttgat actccttggc ggcaggatgt tcattcggtt cgagtaaaag 3012661 ctcggttccg tcttgatcat ctggagaaac aagcgttatc cacctgaatt tccccatggg 3012721 aacgtcttcc ttttttataa acccaagttt ttctgtataa aactccagtg ccatgtcttg 3012781 atcttgtaca aatatactgg taacaacgat tttcatactg tttttccctc cttcgatatg 3012841 aatgaagcat ggtactatgc taacaatctg gctacaagca aaacaaccca cacatttatc 3012901 agaggccctg ttctgatttt ataaaattat tctatccatc ctttcagcaa atttttaagc 3012961 ggttcgttgt tgaatataag tactcgatat tttccctttc gttttgatgt tacgagtcct 3013021 gcatcctcca gtacagaaag gtgtttagct atcgcctgtc gcgtaataga aaggtcgtac 3013081 tttgtaataa gacgtatcgt aagttcatac aacgtcagct cgttgcgttc agataattcg 3013141 tctaatataa gccgccgagt cgaatcgccg agtgctttga atatagcgtc tttgttccca 3013201 ttcatatatt gagtataagc aacccattag ttgcatgtca agtataagca actgtatggt 3013261 tgcgtgatat agaaactgaa cctatccggc gcaggtctga aatattctaa tcgataagga 3013321 attaaaacca ttaaaataac agtggatatg tctctgaaaa ataaaagaag acgaacttca 3013381 aaagttcgtc ttctacaatc aaattcggca cgccggccat tttaaagttg ataactatct 3013441 ctaaacccct tgataaacaa aggagttttc atcattaacc gatagaacct tccatttcga 3013501 acttaatcaa acggttcatt tcaactgcgt attccatcgg aagctctttt gtgaatggct 3013561 cgataaagcc cattacgatc atttcagttg cttcttcttc agaaataccg cggctcatca 3013621 agtagaagag ctgctcttca gatactttag acactttcgc ttcgtgctcc aatgaaatgt 3013681 tatcatttaa gatttcattg taaggaattg tgtcagaagt tgatttgtta tccataatga 3013741 gcgtatcaca ctcgatgtta gagcgggcgc cttccgcttt gcgtccgaag tggacgattc 3013801 cgcggtacgt tacttttccg ccctgttttg aaatcgattt tgatacgatt gtagatgatg 3013861 tgtttggtgc aaggtgaatc attttcgcac ctgcatcctg atgctggcct ttacccgcaa 3013921 gagcgataga aagcgtcata ccgcgcgcgc cttcgccttt taggatacaa gccggatatt 3013981 tcattgtcag cttagaaccg atgttgccgt cgatccattc cattgttgcg ttttcttcac 3014041 agactgtacg ctttgttaca aggttgtaaa cgttgttcgc ccagttttgg atcgttgtat 3014101 aacggcagta gccgcctttt ttcacgatga tctcaacgac cgcactgtga agtgagtttg 3014161 ttgtgtaaac aggcgcagta cagccttcaa cataatgaac gcttgcttct tcgtcaacaa 3014221 tgatcagtgt acgttcgaac tgacccatgt tctcagagtt gatacggaag taagcttgta 3014281 gcggtgtttc aaccttcacg cctttaggca cgtagatgaa agaaccgccg gaccaaacag 3014341 ctgagttaag cgccgcaaac ttgttatcag tcggcgggat tacttttgcc cagtgctcac 3014401 ggaaaatatc ttcattctct ttcagcgcgc tgtcagtgtc tttaaagacg atgccttgtg 3014461 cttcaagatc ttctttcatg ttgtggtata caacctcaga ttcgtactga gcagaaacac 3014521 ccgcaaggta tttttgttca gcttcaggaa taccgagctt gtcgaatgtt tgtttaattt 3014581 cttcaggaac ttcatcccaa gaacgctctg aacgctcaga cggttttacg tagtacgtaa 3014641 tttcgtcaaa gttcagtgag tttaaatctc cgccccattg aggcatcggc atattgtaga 3014701 aatgctcaag tgatttcaag cggaagtcaa gcatccattg aggctcttct ttcatgcgag 3014761 aaatttcttc tacgatttct tttgtcaatc cgcgctctga acggaaaatg gaaacgtcct 3014821 tgtcgtgaaa accatacttg tattcaccaa tatcaggcat ttttttagcc atccattttc 3014881 actccaatcc ttttaattgc cgccttcttc tttcgcgact cctttttcaa gtgctttcca 3014941 tgacagggtt gcacatttga tacgggcagg gaattttgaa acgccttgaa gggcttcaat 3015001 atccccgaga tctatagaat catcatactc tttcccttgc atcatatccg agaaaatctt 3015061 agacatggaa agggcagttt caatatcttt ccctttaatc gcctgagtca tcatcgaagc 3015121 ggatgccatt gaaatggaac agccttcccc ttcaaacttc gcatcttcca cgatgtctcc 3015181 gtcaagcttc attgtcagtc tgatgcggtc gccgcatgtc ggattgttca tatccacgac 3015241 aatgctgtca tttaaaaccc ctttatttcg cgggtttttg taatgatcca taatcacctg 3015301 tctgtacaat gtatctaagt ttgcattaaa agacatttgt aaaatactcc tttgtctttt 3015361 gaagagcttc cacaagctta tcaatctctt cctctgtatt atacagataa aagcttgctc 3015421 ttgcagtagc agttacatcc agccatttca tcagcggctg cgcacaatgg tggccggctc 3015481 tgactgcgat tccctccgca tcaagcacag tcgccacatc gtgcggatga acatcatcaa 3015541 ggttaaatgt gacaagcccg gcacgctctt ccggcccgta aaccgttacg ccgtcaagct 3015601 ggcggaagcg ttcaagcgca taagctgcaa gcttgtgctc atggcgggaa atctcatcaa 3015661 gaccgatttc ttcgagaaaa tcaatggcgg caccgaggcc gattgctcct gcaataatcg 3015721 gcgtacccgc ttcgaatttc cacggaagct ctttccaagt tgattcataa agcccgacaa 3015781 agtcgatcat ttcaccgccg aattcggcag gctccatgtt ttccagcagg gctttctttc 3015841 cgtacagcac accaacaccg gtaggtccgc acattttatg ggaagaaagc gcaaagaagt 3015901 cgcaatcgag atcctgcacg tcaattttca tgtgaggcgt gctttgtgca ccgtccacca 3015961 caatgacagc cccattgtca tgagcgattt tcgccatttc tttaatcggg ttgaccgtgc 3016021 cgagaacatt agatacatga gacaccgcaa caatttttgt gttgcttgtg accgtttctc 3016081 tgacgtcttc taaagaaatc gttccgtctt cctgcaacgg aatatatttt aatgtggcgc 3016141 cagttgcttt tacagcctgc tgccacggaa tgatattcgc atgatgctcc atgtaggtga 3016201 tgaccacttc atcaccaggt ttcaggttgg cgcgcgcata gcttaacgcc accatattca 3016261 gtgatgtggt cgtgcctttt gtgaaaataa tctcagccat tgacttcgcg ttaataaact 3016321 tgcggacttt ttcacgcgct ccttcataac catctgtcgc tctggttcca agtgtatgga 3016381 cgccccggtg aacattggaa ttgtattggt tataatactt atccagtgtt tcaatgacag 3016441 cacgcggctt ctgggaagtc gccgcgctgt cgagataaac gagatcatgt ccgttcactt 3016501 gctgatgaag gatcgggaac tgttcacgaa tatctgtgat attcattact tcactttcct 3016561 ttcgataaca gaaactaatt gtttcttaac gccttcaatc ggaagttcat ttactaccgg 3016621 tgcaaggaat ccgtaaatga ctaagcgttc tgcttcttct ttcggaattc cgcggctcat 3016681 caggtagtaa agctgaatag ggtccacacg gccgacagat gccgcatgtc ctgcagttac 3016741 atcgtcttcg tcaattaaaa gaatagggtt tgcgtctccg cgtgcttttt cgctaagcat 3016801 cagcacgcgt gattcttgct ccgcattcgc tttagaagcg ccatgttcga ttttgccgat 3016861 tccgttaaag atagaagaag cggaatcctt catcacaccg tgcttcaaga tatagccttc 3016921 agaagcttta ccgaaatgga tgatttgtgt tgtgaagttt tctgtttgct ctcctcttcc 3016981 gacaacaacc gttttcgtat cgccgtatgt gccgtcaccg taaaggtttg ttgtgttttc 3017041 ggaaatcgtg tcgccatcgt tcatcaggcc gagagcccac tcgattttgc tgtcgcgtcc 3017101 gcgcgcagca ccgcggcggt tcacataagt tgtcacaccg cttgacagat tatccaccgc 3017161 accgtatgtc acgctggcat tatcacctgt gatgacctca ctgataatat tgaagacagc 3017221 gtctttcggg tttacagtgc tgatgtagtt ttctacatat gttacagagc tgtggtcttc 3017281 agccacaatc agcacgtggt tgaatagagc tgtatcattg ctttcgtgga cataaacagc 3017341 ctgaaccggc gtctccacct gaacattttt cggaacataa aggaatgctc ctccgttaac 3017401 aagagccgcg tgaagtgcag ttaacttatg ttcgtcaacc ttcacgccgt ccttcataaa 3017461 gtatttctcc accaagtcgc tgtgctcgcg tgcagcagtc agaatatcag tgaagatgac 3017521 gcctttgtct ttcaattctt gagaaagaga aagatgtgcc ggcgtctggt cacgctgtac 3017581 gtataatgtt ttatcttcgt tttcaatgtc gatcagcgct tttacttcat cagtcaaatc 3017641 ttctaatgaa gaaagcggtt cgttatccac tgtatgcttc gcgaaattcg tgaagttcca 3017701 gtttgtgatt tttgttttgt caggtttcgg catcggcaga tcctcagctt gttcaagagc 3017761 ctgtaagcgc aggttcttca gccaggcagg ttcttggtgc ttttcggaaa agcttttgag 3017821 atactcctga tctacggata gttttgtacc tagtgtcata ttaatccccc taacgcttac 3017881 gcttcttggc caacagtttc gtcttcaatg ccaagttctt gtttgatcca gtcataacct 3017941 tctgcttcaa gacgctgtgc aagctctgca ccgccggatt ttacaacgcg gccttgcatc 3018001 ataacgtgaa caacatccgg agtgatgtag tttaacaggc gctgatagtg agtgatcatc 3018061 aggcagccga agttttcgct gcgcattttg ttgatccctt ttgatacaac tttcaaagcg 3018121 tcaatatcaa ggcctgagtc aatttcatca aggatggcga ttttcggttc aatcatcatt 3018181 aattgaagga tttcgttgcg ttttttctcc ccgcctgaga agccttcgtt aagatagcgc 3018241 tgagccattt cagggtccat ttcaaggaac tccatgtttt cgtccatttt gcggatgaat 3018301 ttcatgagag aaatttcatc gccttcttct ctgcgcgcgt tgattgctga gcgaaggaag 3018361 tcggcatttg tcacaccgct gatttcactt gggtactgca ttgcaaggaa taagcctgcc 3018421 tgcgcacgct cgtccacttc catctccagt acatctttgc cgtcaagcgt gatgctgcct 3018481 tttgttactt catatttagg atgccccata atagcagctg ataaagtgga tttaccagtt 3018541 ccgttcgggc ccattactgc gtggaattct ccacctttta tttcaaggtt tacacccttt 3018601 aagatctctt tcccttcgat ttcaacgtga agatctttga tcgttaatgt tgaagcagcc 3018661 atatctatac ctccaaaaat atataatcat tattctcatt ttattctcat tctaatttta 3018721 taacaaatga aaagtaaata caacttttta tcgtgccttg cacattcctc aagtttaaca 3018781 aagatcagca ctttattaaa gcgattgaaa aagaaaaaga gtggattccc accctttttt 3018841 aaaagattga ttttctcaat aagctcccgc agaaatccgc ttgctttttt cataatcaag 3018901 ctctctctgc cgctctactt tcattcttgt ttccagccgg cgtccatatt cctcgtatcc 3018961 aattccgtgt gacagctgca tcgctttttc catttctgac gtataatcga ggttcagtct 3019021 gtcctggctg ctgcaaataa tgaatcaatc ccttcatata tttgcttttt attgtaccag 3019081 tgctgcgttg gatgccgcaa aaacgatttg gcgtgaaata gcggcagatg agacgaaagc 3019141 atcctttcag aacaaatgag aatggttttt cggaatattc cttctcttaa tgcgtggtgt 3019201 ttccgaattc ctcaatgcac tgttgaacga ctgtcacgcc ttggctgaaa gctgcgccgc 3019261 ctccaaatgc cgctgccaca ctgacggctt cgagaatgtt ttcttctgac gctccctgat 3019321 caagacagcc ttttgtatga tagatcatgc aatattcgtc ctgagcattg atggcaattc 3019381 cgagggcgat cagctgtttt tctctttcag tcagagaatt cccggcaaag cactgttcag 3019441 taaattcgtt aaattttctt cccatcagcg gcatcttttg ttcaaatgtg cctaaaccat 3019501 gtttatattg ttttaacgcg tcctgcatgc ttcctctgtc ttgattcaaa gaaaatccct 3019561 ccatctgttt aacattcctt tttattatga acagctttta ggaaaatacg cgaaaaaaac 3019621 cccggaattc tcatccgggg tttcagtctt attcagatac aggaagcaca gctccgtcgt 3019681 attttttctc gatgaagtct ttgatctttt tagagtgaag aacttccatc agcgctttga 3019741 tttttgcaga atcttcttcg ccttttctta ctgcgatgat gttagcgtat gggttgtttt 3019801 tcgttgattc tacttcaatt gcgtcttttt taggatttaa tttattttgg atcgcatagt 3019861 ttacattgat gaagaccgcg tctccttctt tgttttcata tgcttttgcc gttaattcag 3019921 gcgctacttt tttgaattca aggtttttcg ggtttttctt aatgtctttc aatgttgcgt 3019981 caactgtttc cactttagaa tcaagagtga ttaatccagc gttttcaagc attgcaagca 3020041 tacggccttg ttcagcaacg ttgtttgtca gaatgattgt cgcaccgtct ggaaggtctt 3020101 tcagtgattt gtatgtttta gagtaaatac cgaatggctc taagtgaaca gcgccggcat 3020161 tcacaagttt gtaatctgtg ttttctttca tttcttgctc aaggtaagga atgtgctgga 3020221 agtagttcgc gtccacttct ttatcagcta aagctttatt gtacattttg taatcactaa 3020281 gcactttcac tttcagcgta tagccttttt ctttcagcaa tggttcagct tcttttaaaa 3020341 tttccgcatg cggtgttttt gttgccgcaa cgacaatttc tttcttgccg gattcagcgc 3020401 cgttattcga accgcaggca gccataactc ctgcaaatac aagcagtaat gcacccaaaa 3020461 atagcttttt caatgtaaat cctcccttat cgtttgtcta taatatttgt tattagatca 3020521 ccgatgattt gaataataaa cacgatgatt aaaataaaca cagtagcaac gaaggtaaca 3020581 tcagcgttat tagactgata tccttctacg tacgcaaggt ttccaaggcc tcctgaacca 3020641 atggctccgg caattgccgt tgaaccgatt aaagcgatgg ctgtaaccgt aatgccagaa 3020701 ataagagcag gcattgattc cggaatcagc actttgaaaa taatcgtaga cgttttcgcg 3020761 cccattgatt tagctgcttc aatcacacct ttatccacct cacgcagcgc gatttcaaca 3020821 aggcgcgcgt aaaatggtgc cgagccgatt accagcgccg gcaatgcggc gtttggccct 3020881 aagatcgtgc cgactaaaaa tttcgtaaaa cctaatagta aaataattaa aataaggaac 3020941 ggaatcgatc tgaatatgtt aacaacggct gcaatcactg agttgaccgc tttattctgc 3021001 cagaggcttc ctttgctcgt cagaaagagc agcaagccga ggatgacccc gatgacaaaa 3021061 gcaaacagta aagaaatcag cgtcatataa agtgtttcat atgtcgcgtt ccataattca 3021121 gttaaatcaa cgttcgggaa gtatttttca aacattcgtg atcacctctg ctttcacctg 3021181 tttgtcatta atgaatcgga tcacgttttg cacttcttcc tcgtccccgt caatgtggat 3021241 gaacagtgaa ccgtaagccc catccttcgt ctgcgaaatt ttcccttgca gaatattgac 3021301 gctgacattg aagtttctga tcatctctgt aatcagaggc tgttcagctg actcaccgac 3021361 aaatgtgagc tgaaccattt ttcctgatgc tgtatcatca agaaggtgct gaagcgtctc 3021421 tttcgtttct tccggctctg tcacctgttg aacaaatcgt tttgtcattt gttcctttgg 3021481 atttttgaag acatcgagaa cctcgccttc ttcgaccacc ttgccgtttt ccatgacggc 3021541 gactctgttg cagattttgc gtatgacatg catttcgtgc gtaatcagca caatcgtcaa 3021601 accgagtctt tcattaatat cggacaatag atccagaatt gaatctgtcg tttgcggatc 3021661 taatgctgat gtcgcttcgt cacaaagaag aaccttcgga ttgtttgcaa gcgctctggc 3021721 aattccgaca cgctgcttct gaccgccgct cagctgggac ggataagatt tttcttttcc 3021781 ttctaaacct accagtttaa tcagttcatt ggcgcgcttg atccgctcgc tctttttcac 3021841 cccggcaatt tctaaaggaa acatgatatt atctctgaca gtccgcgacc aaagcaaatt 3021901 gaaatgctgg aaaatcatac tgatctcatg gcgtgctttt cttaaaccgc gtccatttac 3021961 ttcattaatc ttggttcccg ccacttccac ggttcctgag gttggtttct caaggccgtt 3022021 cagcagacgg attaaggaac tcttaccagc tccgctatat cctataattc caaaaatctc 3022081 acctttttta atggaaagcg agacgttttg gacagcattg acatctccat gtttcgactt 3022141 gtaaactttt gaaacatcct gaagattgat caaagcaatc acctgcctta acactattct 3022201 aagaaatctt ccggtttttt ctgcaaaaga aaagcctttc tgcacacttg agcagaaagg 3022261 cttatataaa atgcctttct ctcatctttc aaagctgaac gcttcgtgtg aattggcacc 3022321 atttcaacag tgttgatggt tgccgggctt catagggcac ttccctccac ctctcttgat 3022381 aagagaaata tatagtcttt ttcgtccgga aattcttaat gtagaatagc acggcgaatg 3022441 attaaatgtc aataaaataa atgatgtcaa cttttactat tataataatt tattattttt 3022501 taatttttta aaatcctctg aaaaaatcca tttgtcagcc agagaatggc ttccagcttt 3022561 aacagggccc tgaatgaccc ctttactttg aggcttccgc tctgaataag gtgctgaagg 3022621 gaaatgtctc cgtgcaataa atcaataatt tccgtttggt ttccgtaaaa ggtcaggttg 3022681 gacgtttggg gcggagaaac ttttttcatt tctccctgtt cgtttattga gacggttaag 3022741 gcttctgctt ctccttggaa ggtaatgagc aatgttgagg cattcaaaag gggttttaaa 3022801 aacagatgct gatactcatc ttctaaaact tccgctttct ccatatgtac aacctcctat 3022861 ttgttggtca tacatacaca tttctctctt tgtcgcaaga acccctttat aaaacgaacg 3022921 acaatttcat tggatatgct gagaaatatg tcataaatgg gatgcggaag atgatttttg 3022981 tttgatcagc tcatataaat aagaaacgga atgaaatgca tatcctcttt cgaccatctt 3023041 tccgccttta aacagcagaa aacaagggac gctttcaatt tgatacgctt ttgcgaatgt 3023101 cggagagtaa ttgacattgt tttgatagaa ggcgacatcc ggcagcattt ctttcaccac 3023161 tgtcagcatt ttgcttgcaa gctggcaggt gccgcaaaac ggagtatata aatatagaag 3023221 gtacacatca tcttcaatgt gatcaagttc gtgttcttgg agttctttca tgctatacac 3023281 ctcgggactt tctttcaaga aaaatagtat ggacattcag attcgcacgc agcaatacag 3023341 aagcgatatg gtgcctgggc gcagccgcta cttccttata ggctctgtcg acatggagat 3023401 ggcaggcttc attaaattca cgcttcagct gttttctcaa tttctcacct gattcatcag 3023461 catcaactaa tatatagacg tctttatcat aaagctcgtc agccaattcc tcgagcctca 3023521 gctggctgat tgttccgttt gtgcagataa tgcgcatcgg ttcattcagg acgctttcga 3023581 ttttctcttt atctgatttc ccctcgacaa tcataacctt ttccagctca tccatcttca 3023641 tcttgttcac ctgccgcgtc aaatttgaaa tgttcagatt gtaaaagaag gcagtgaaat 3023701 tcaccgccaa cattaacacc agccgttttc gtagtcacaa tctacatatt ttgcgtcgtc 3023761 tccagagacc acatcggctg tcttataaaa tttctcattt tcaaaggaat aaccggactt 3023821 aagctcatat tcattcatgc ttgtcatttg gccgatcatc tcattatcat gatataacga 3023881 gagccggcca ttttgaaagc ggcctgtcac gtcattggtg acatcgagct tttgtttgtc 3023941 gaaagccata ttggacacct cccataacgt tagcgtgtcc aattgctttt acggctatcc 3024001 tgttttagtc ttcttgtgtc atctcttcgt attgctctgc tgtcatcagt ttttcaattt 3024061 cagaagcgtc agatggctca acgacgatca tccatgcttt ttcgtacgga gattcgttga 3024121 cgaattccgg actgtcatca agatcttcgt ttacttccac aaccgttccg ttaatcggtg 3024181 cataaagctc agataccgtt ttaacggatt caacactgcc gaatggctcg tccgctttga 3024241 tttcagcgcc cacttcagga agttcgacaa acacgatgtc gcctagttcg gactgggcaa 3024301 aatgcgtaat tccgattctg gctttttctc cttcaacttt tacccactcg tgttctcctg 3024361 agtaacgcaa atcttttggt atgctcaatt gaatccctcc attttttaca gcactacaat 3024421 aagaagatac cacacttttc aaaaaaaatt tacattaagc ccagttttct tcaaattggt 3024481 cttctttaaa tccgacagtc actttttcgc cgtctgttgt aagcgggcgt ttaattagca 3024541 taccatctga agccagcagt tcgagctgtt cgtcctctga catatgatac agcttttcct 3024601 tgagattgag ctcgcggtat ttcatgccgc tcgtgttgaa aaatttcttg agatccagcc 3024661 cgcttttttc ataaagcgct tttaattctt ctttgcttgg cggctgctca gcaatatgta 3024721 tttcgtttat ttctttccca tgctcttcaa gccacttctt tgctttgcgg cacgttccgc 3024781 atttagggta ccagtaaaaa gttaacgaca tcttcttccc cctcaataaa ataatcgagg 3024841 ttattttaac acagtttgtt ttaaaaacct aaaacagtgc ttcttaaaaa agagctccgc 3024901 gcatgcggag ctcatggcca atcagacagt atatttctca gcctcaaaaa tgcctgccgc 3024961 cgcctcgcgt tttttctgaa tcacgttttt aggcgttacg cgtgtcagct tgcgcagagc 3025021 ggaaagcatc atgcggagtg aatctccttc ttccattgcg ataagggatt cctttgcatg 3025081 cgcttcgatt tcgttaaagg cctcttgaac gaaaatttct gtgtacagca ccttttgcgc 3025141 tgctttttca gcgccttgtg cggcaatggc cttttccgtt ctgagcacgg ctgattccat 3025201 tgcgtataca ttgctgacga tatccgctac gttcacgaga atttcttgct cacgatcgat 3025261 cgcttttccg tatttttgcg cggctaggcc ggcagcaaac aacgcaattt ttttggcttg 3025321 cttgacgata tatttctcct gctctaagac gccgcttcca ggctcttcag gcataagcat 3025381 catgagttct tcctgcagcg actgcgcttt ttcgaataaa ggcagctcgc ctttaagcgc 3025441 ttttttcagg aaggtgcttg gcacgattaa ccggttgatt tcgtttgtgc cttcaaaaat 3025501 ccgattgatc cttgaatccc tataggccct ttctacttcg tattcctgca taaagccgta 3025561 gcctccatga atctgcacgc cttcatcaac gatataatca agcgtttcag agccgaatac 3025621 cttattcaga gagcattcga tggcgtattc cgcaatcgat ttggcgattt gccggccgtc 3025681 cttgagatct tcggccgtga actggctcat attgtcttca aacagcccga cggttctgta 3025741 tacagagctt tccatcgcat acagccttga ggccattgtc ccgatttttt cctgtgtcaa 3025801 tgaaaaacca gcaatcggcg ttttaaattg gcggcgctga tttgcgtatg ccgcagacag 3025861 ctcgatgacg cgtttagatg cgccgattgt gccaaccgcc agtttgtaac ggccgatgtt 3025921 taaaatatta aaggcgatga catgcccttt gccgatttct ccgagcaggt tttcctttgg 3025981 cacttcagct tgatccagaa tgagggttct tgtcgatgat cccttgattc ccattttctt 3026041 ttcttccggt cccgtggaga cacccgggaa ctctttttct acaataaagg ctgaaaactt 3026101 gtcgccgtct accttagcgt aaactacaaa tacatcggca aaagcagagt tggtaatcca 3026161 ctgtttttcc cctgttaata cataatgggt tcctgcttca ttcagcacag ctgttgtttt 3026221 tgctccaagt gcatcagacc cagagccagg ctcagtcaga gcataagcgg cgatcttttc 3026281 gcctgaagcg agtccaggca aatatttttt cttttgttct tctgacccga aaaagacgat 3026341 cggcaaggaa ccgataccga catgcgcgcc ataagaaaga gaaaagcttc ccgcacgcga 3026401 aaatttctca gtgatgagtg ccgagctgat tttatcaagg ccgagcccgc cgtattcttc 3026461 cggcacatcg gcgccaagca gccctagttc gcccgctttc ttcaacagtc tgacagaatg 3026521 ctcgaattga tggttttcga tatcatctat atgagggaga acatcttgct cgatgtaatc 3026581 ctctgttgtt ttcgcaatca ttttatgctc gtcagtgaaa tcctccggtg tatacatttg 3026641 atcgtatgtg acatcctcga ttaaaaatcc gccgcctttt tgtacgtcag ccgctttttt 3026701 tgccatttgt ttttccccct ttagcataat tcaaatacac cggccgctcc cattccgccg 3026761 ccgatacaca tggtcacgac tccaaattgc tcgtttctcc gtttcatttc atggatgagt 3026821 gagagtgtaa gctttgtgcc cgtacagcca agcgggtgtc caagcgcgat tgcgcccccg 3026881 ttgacattca ctttttcttc atcaattccc aattccctga ttacttgaat ggcctgtgag 3026941 gcaaaagctt cattcagttc aaacaagccg atgtcctgca gctgaagtcc ggcaagcttc 3027001 aaagcgcgcg gaatcgcttc caccggtccg attcccatca cttccggcgg cacgccgcct 3027061 accgcaaagg agcggaattt cacaagcggc gccaggccaa gagcatcggc tttttcccgg 3027121 tccatcagca tgacagccgc cgctccgtca ctcgtttgtg aggaattgcc cgcagtcacc 3027181 gtcccgtcaa cggaaaaggc cgggcgcaat gtcgataaga tgtctgcagt cgtttgcggg 3027241 cgaacacctt catcctgaga aaacacaaac tgtttttcca taggcttatg gtcttctccg 3027301 atttctgtca ccgtcacttc gacgggtaca atttcatctt taaattttcc ttctgcaagg 3027361 gctttagcgg cgttttgatg gctgcgaacg gcaaacgcgt cttgatcctc acgggagacg 3027421 ccgtattttt tcgcgacttg ctcggctgtg tgccccatgc tcatataata ttccggtgcc 3027481 ttttctgcca aagcaaggtt cggacgggta acatgcccca tcatcggaac ttgcgacatg 3027541 gattctgctc cgccggcgat cgctgtatcg taggcgccca gcataatttt ttctgctgca 3027601 tacgcaatag actgaaggcc tgaagagcaa tagcggttaa ctgtaatcgc cggaaccgtg 3027661 tacggcaggc ccgcgagcgc accgatattt ctcgccatat taagcccctg ctccgcttca 3027721 ggtgttgcac agccgataat caagtcatca atattgcctt cgtagccgcc tgcccgtttc 3027781 agcgtttctt ttacacaaat cgctcccaaa tcatccgggc gaacggtggc caacgatcct 3027841 ttttttgctt ttccaaccgg tgttcttgca cctgacacaa tgactgcctc tttcataagc 3027901 tccctcctaa ttccgtaaag gtttaccttt cacaagcata tgctgcattc tcgcttgaga 3027961 ttttgcctct cctgacaaac tcaaaaacgc ttctctttcg atctccaata aatactcttc 3028021 atcaacctct gtaccaaacg gcacttttcc gcccgcaatg acataagcga gttttttcgc 3028081 gatcttaaaa tcatgctcag atatatagcc ggacagcttc atctgctcag cgccaagcaa 3028141 gagtgccgca taaccggttt ctcccggcac cttgaccttt tcttttacag gcggccgcca 3028201 gccggtatcg tataaagatg cggccagctg cttcgcatcg tataacaggt ggtcttgatt 3028261 cacgctgatc tgatccgttt cttttaagat gttcatctca cgagcctctt gagcggaagc 3028321 ggacactttc gccatcgcga ttgtttcaaa tgttttcatt gccgcattca tcggatcatg 3028381 gccgcggcga agatggttga tgtacagctc tttgttacct cctccgccag ggatgaggcc 3028441 gacaccggat tccacaagtc ccatataggc ttcgcttgcc gcttgaatgc gcgccgccgg 3028501 caggcatgct tccgttcctc cgccgagcgt catgccaaat ggcgcggcga cgaccggttt 3028561 cgcactgtat ttgatcttca tcatcgtctc ctgaaaacgg cggatcacaa aatcaacttc 3028621 caaaaagttg tcatcttgga cttccattaa gatcatggcg agattcgcgc cgacgcagaa 3028681 atttttccct tgattgccga tgacaagccc cttgtaattc cgttctgttt cctctaatcc 3028741 tttgtggatc atttgaatga tatcgaggcc gatcgcattg cttttcgaat gaaattcaag 3028801 aagggccaca tcatctccaa ggtcaattaa gcttgctccg ctgtttttcg caatcacgcc 3028861 ttttgtttct ttaagtgctt gtaaatgaat tcgttttttg ttttctttca cggctctgta 3028921 ttcgccgcgg tcataataaa ataccgttcc gttctctttg atgtagaagg tttcatttcc 3028981 tttgtccagc atctctttta tccagccagg catatctgct ccaagctgct caagcttttc 3029041 cgctgactgc ttgaggccga tggcgtccca catctcaaaa ggtcccagtt cccagccgaa 3029101 tccccacttc atggcttggt caatcgcatg aatatcatcg gcaatctcgc caagcagctc 3029161 ggctgagtaa agcagggttt gagaagtgat attccacagc aaacggccgg ccctgtcatc 3029221 cgaataaata agcgctttca ttttggcttt tgtccctttt gcctgttttg ccgcttcaag 3029281 tgccggtgat ttcatttttg tccgctcgcc gtaagtaagc gtcactgggt caagctcata 3029341 aatcgttttt ccttcttttt tataaaagcc ttggccggcc ttgcttccga tccacccttt 3029401 ttccagcata tcgttcatga agcttggaat gcgaaacact tctttttcat cgccatcagc 3029461 tttgtcatac acatttcggg caacgtgggc gaatgtatcg aggccgacca catcaagcgt 3029521 tctaaaggtg gcgcttttcg gcctgccgat cagcggtcct gtgatcgaat caacctcccc 3029581 gacctgataa ccgcctttca gcatttcttg gactgtcacg agaagcccgt aagtcccgat 3029641 gcggtttgcg ataaagttcg gtgtgtcctt tgctgtaaca acgcctttcc cgaggacatt 3029701 ttctccgaaa gctgtcataa actttaaaat atcaggatcc gtttccttaa tcggaatgat 3029761 ctctagcagc tttaaatatc gtgcgggatt aaaaaaatgc gttccaagaa aatgggcttt 3029821 aaaatcatcc gaccggcctt cagccatttc ctgcactgat atgccggatg tgttgcttga 3029881 gacgatgctt ccagtctttc gatgttcatc cacaagagcg aaaattttct ttttgacttc 3029941 aaggttttcg acaacgacct caataatcca atctgcttct ttcagttttt ctgcatcatc 3030001 ctccagattg ccaggtgtaa tataggaggt atttttcgct gatgtgaggg gagcgggctt 3030061 ttgtttcagc agttttttca tcgcctgccg gctcagcctg ctgcgcacct ccgaactgtc 3030121 cttcgtcagc cccttttttt cctcttcctt tgtcaaatcg ttcggcacaa tatctagcag 3030181 caggacagga attccgatgt tagccaaatg cgccgctatc ccggaaccca ttacccccga 3030241 tcctaaaacg gctgccttcc gaatgtgttt gtgcatgaga tatccccctt gaacattgaa 3030301 tgaatagtca ttcatttttt gactaaaaaa aatgaaaccc gtttcttctt tcatcttaaa 3030361 agatttccgg ttcgacttca atagctaatt tgttattttt ttgtatgaag cctataaaag 3030421 tcgggcaact taagcccgga ggtgaaggga atggtacgag agaaaaaaaa tccgtcttca 3030481 gcggcagtca gcgcggcgag cgtaaaggga gatgccggtc cgactcagca ttacggcggc 3030541 ggaaaacgga caagtcaaaa tcagcagtat aaaaaacata acatgggaca atcataatgc 3030601 agctgcttcc cacggctgct ttcacttttt caaaattcct tttaacacaa acgctgcatt 3030661 ggcaggccgt tcggcaattc ttctcataaa gtagctgaac cagtccgttc catatgggac 3030721 atacacacgc attctgtagc cttccttggc gagttccttc tgacgctccg gcctgatgcc 3030781 gtatagcatt tgaaactcaa attgcgatgc ggggatttga tgttcggcga cgagctgttt 3030841 cgtaaatgca atgatgtcat cgtcatgtgt ggcgacagcc gtgtagttcc cgcttaacaa 3030901 ctgcagcttt attaagctct gaaaatgaag gtccgtgcct cttttgtcgg gaaacgctac 3030961 agccgcagat tctttataag cgccttttac aagtctgaga ttcggcttta agtcccgcat 3031021 ctttctgata tcttctgccg cccggtacaa atacgcctga atgaccgtgc cgagcttctc 3031081 aaattcctgt ttgcattgcc tgtaaataga aagtgtctgt tcataatgag aatagtcttc 3031141 catatcaatg gtcacagcaa catcatattg cttcgcaacg gaaagaatgg cgcgcaaatg 3031201 agtaagagca agttcttctg aaagatcgag cccgattgag gtcagcttaa gtgaaagctc 3031261 tgaattcaat tgatgttcgg caatggcttg aatggctttc ttgcattcct ctgcgacttg 3031321 gtttgcttct ttttccgaag ctgcatactc gcctaaataa tcaattgttg cacacaaacc 3031381 ggatctgttt agccttttga cggtcttaac cgccgattca atcgtatccc ctgcgacaaa 3031441 ccttcgtgct ccaagccgcg ttccgtatgc ttttgcgaac ttggtaagtg ttttattttg 3031501 agataagaat aaaaacacat gtctcaacat ccgactccct cccgccgtca tcttcaaaac 3031561 acctgtatat aactcccagt ctgaaggaaa ctataaaatg aacagaaacc aaaggaggat 3031621 cacaatggat aatcagcagc aatctcaaat gccgccttcc gttatttcga caaaggatca 3031681 tttgtatctc aatgacatgc tgaactggaa tttgctcgcg atgaaaaaag cgcatttcat 3031741 ggcgcagcag tgccaggatc aaacgttaaa gcaagaactc gaccgcgtcg gacacatgca 3031801 tcatgatcac tatcaaagaa tattaaagca cctgcagcca ggccagcagc agtccggcta 3031861 catccaataa ggaggcgcca gaatgaatca gcaaaatcaa aaaatcagca acccgcagac 3031921 acctgtaccg acaacatcgg aaatgaatga cagagatttc gtcaacgaat tgctgacaac 3031981 cgaaaaatac atgacaacag cttattgcac tgccttgcac gaattcagcc acgagtctct 3032041 ttatcaggat attcaatcca tttttgatga gtcacaaaaa gcgcaaagaa aactatatga 3032101 tctcatgttc caatatggat ggtattctgt tgaagcggag gattcacaaa agctgcagca 3032161 gtcctatcaa aaattccagc agaccattca gcagcagtct ccttatcagc aataacaaca 3032221 ttagtaaaaa ggatacgatg ttctttcggg catctatcct ttttttgtgt aaaatcagtt 3032281 gacttttcat ttacgcttat ttatatttaa taagcattaa ctattttgtc attaaaatat 3032341 atatacagtg tatgtaacag aggggaaatg aatatgaaga gtgcggatca gttaatgtcc 3032401 gatattcaat tatcgcttca ggcgctcttt caaaagatac agcctgaaat gctggaaagc 3032461 atggagaaac aaggtgtcac cccagcgcag ctgtttgtgc tggccagcct aaagaaacac 3032521 ggcagcctca aagtttctga aattgccgag cgtatggagg tgaagccaag cgcggtgacg 3032581 ctgatggcag atcgccttga acaaaaaaat cttatcgcca gaacacacaa cacaaaagac 3032641 aggcgagtga ttgatctcag tcttactgac gaaggagaca taaagttcga ggaggttttg 3032701 gcgggcagaa aagccataat ggcgcgctat ctttcctttt tgacggagga ggaaatgctg 3032761 caggcggcgc atattacagc aaaactcgca caagcagcag aaacggatga aaagcaaaac 3032821 atgaaaagag gaaacggatg aaaatgagta aagaaggcaa acaatcaaaa cgaacgttat 3032881 taataacagg cttaattatt gccatgtttt tttcagccct tgacggtacc attgtcggaa 3032941 cggccatgcc gaaaattgtc ggtgatctgg gcggtttgag catgatgacc tggctgacaa 3033001 ctgcatattt gttaacatca acaaccattg ttccaattgc cggtaaactg gctgatttat 3033061 tgggacgccg cattgtctat gtatcaggtt tgattatttt tatggccgct tctgctttgt 3033121 gcggaatggc caacaacatg acggaattga ttatcttccg tggactgcag ggcatcggcg 3033181 gaggcatcat gatgccgatg gcgatgattg tcatcggtga cttgttcaca ggaaaacagc 3033241 gtgctaaatt ccaaggtgtc tttggcgcaa tttacgggct ggcttcagtg attgggccgc 3033301 aaatcggcgg ctggattgta gactcgttaa actggaaatg ggttttctat attaacctgc 3033361 cagtcggaat tattgcggtt atttttattg ccaggggatt acagggacgc cagcagactg 3033421 gtccgatcaa cttcgatatc gctggtattt tcacaatgat tgtcggtgtg gtcagcctcc 3033481 tgctcgcctt aagctttggc ggaaaagatt atgcatggga ttcatggcag attcttgggt 3033541 tgttcgctct cgcactgatc ggcattgtca gctttatcat cgtagaatca aaagcaaaag 3033601 agccaatcct gccaatgtat ttatttaaaa acagaacatt tacatttcta aacttgatcg 3033661 gcttctttat gagtatcggt atgtttggcg ccattacgtt tgttcctttc tttatgcagg 3033721 gaattgtcgg tgtaagtgcg tctgaatcgg gtacaattat gacaccgatg atgatttcta 3033781 tgattatcac aagtatcatc ggcggacagc ttgtttataa aattgggatt aaaccgcaaa 3033841 tcattacagg catgctggtt atggccggcg gattcctgct gttaacgaca ttggatctcg 3033901 acacgagcaa gcttgtcgct acatctttta tggcgattat tggtctggga atgggtcttg 3033961 ttatgccgat tctgacattg gctttacagg aaagcttttc gaaggaggag cttggagttg 3034021 tcacttcatc cagccaattc ttccgttcta tcggcggaac attcggcatt accatgctgg 3034081 gagccgtaat gaatgcgaga tcaggaaatc tattaacaga taaattggtt ccatatttag 3034141 actctcttcc ggcacaggca agctcgtttg ccgcccagct aaagggtatg attgatacaa 3034201 atccgcaagg gctgctgcaa tcactgttca gtccggacgc ggtcaaacaa atccctgcgg 3034261 ctttctcatc ccatattgtg ccgattttaa aaacatcgtt gatggattcg ctccacagcg 3034321 tgttttatac gggcctgatc tttatcgcag tcggagccgt attcaccttg ttcttaaaac 3034381 ctatcaagct atcaaataag aaagcggaag accaacaaga aaaagagaag gcggcaaaag 3034441 ccgttgaatc accttcccat taatagagca ccccgcgggt atcaatccgc ggggtttttt 3034501 attcaatcat ctgggctctt ccatttccga aagaccaatc ctcatcctga tttccggcca 3034561 gcatgataaa cacatcttct tttcttacac caagctcgga atgaatccgg ctcgcgattg 3034621 agcggtaaag tgcttttttc tgttcagttg ttcttgactg tttcagtgta aaatgaatgt 3034681 atatcagttc atcagtacgc tcgacttgga gataaaatgg atcataaaaa aattcgcttt 3034741 tttcatattg tctgatgact tggaaatagt catcttccgg cacattgatt tcttcaatca 3034801 tcgattggtg gatagtcctg ctcagttttt gaagccacac ttcgcttctt cccgaccgta 3034861 aatgaatctg tacaaatggc atctccccgc atccctttct ttacagcgtc tgtccgctgt 3034921 caattgtgat aatttggcct gtgagtgatt cctgttcaat tagtgaacaa atcaatttgg 3034981 caacatcatc tggttcagca atacactgca gcagcaaaga gccgatcatg cttttcattt 3035041 tttcttcccg tccggcccac catctcgttg ccacagctcc tggtgctaca ccgctcactc 3035101 tgatttcagg cgctaaggcg tgggccaatg atttcgttaa accgtgcacc gctgattttg 3035161 atactgcgta aggcattgat gagccggcac cagttatccc tgcgatgctg ccgacgttta 3035221 cgatcgcccc gtccttgctt ttcttcatga acggaaccac tgcccgcgcg cagaaaaaca 3035281 tccctttcac attgacggca tacagctcat cctagacgtc ttctgtcgca gcctcaagat 3035341 catccattgg aatatgccgt gtaatgctgg cattgttgac taaaatatca accgtgccgt 3035401 gtgtgttcac gattgcttga atcatatcct gcacgtcgct gtttttggat acatctgctt 3035461 ggatggcgaa ggcttgcccg ccagcttttt gaatcatttc cactgtttcc tccgcttctg 3035521 attgcgagcg tgaataattc accgccacaa tcgccccacg ctttgccaat tccatactgg 3035581 ctgcttttcc gattcctgtg ccgccccccg ttacgagagc tattttgttc aagacattca 3035641 ttgccgccac tccttgctgt tgactaaagt atatttctga ttccattgta atccagcttt 3035701 gatgttacgt ataatgattg ttaaagatac tagatatcac tcagattgat agtaaacgaa 3035761 cggaggagtt caaaatggaa agcggagatt tacgtgtgtt tcaaatggta gctcgtgaag 3035821 ggaccattac gaaagcagcc ctgcagcttg gctatgtaca atcgaatgtc acggccagaa 3035881 ttcaacaatt ggaagctgag ctgggtacca cactgttttt gcgccataat cggggcatga 3035941 cactttctgc aagcggaaaa ttgctgctgg actacgcaaa taaaattata ggccttcttg 3036001 atgaagcgtc taaagcgctc tcatcctccg cagaaccaag cgggccgctt atgatcggct 3036061 gcactcagac aaccgccgcg gtaaggcttc caaagcttct ggcatcttat tatgaagaac 3036121 atccaaacgt ccagctgtct ttaacaacag gacatacgca atttctcctt gataaagttc 3036181 ttcgttatga attggatggc gcgtttatcg gatgcgaatg ccatcatcct gagctcgaat 3036241 cctatcctgc gtttgaggaa gaaccagtag ttgtttcggc tgcctccgtg cccgatgttg 3036301 aggaagccat cacaaagccg attctcgttt acagcacagg ctgttcgtat cgagaaacac 3036361 ttgaaaaatg gctgcgttcc gtcggtgtca cacagccggt cattatggaa tttgggacgc 3036421 ttgaagcaat tatcggcggg gttacagcag gtcttggcat ctcgttgctg ccaagaacgg 3036481 ttgtgcagaa acatgaagca gaaggatcaa ttcgattgta cccgctgcct gaagctctca 3036541 gccagatgaa aacagagttt attgttcgaa aagattcgtt tatcagcagc gcgctgagaa 3036601 cctttatgga ttcctttacg ccagttaaaa cggctgaatc acaaaaaagc agtctgctat 3036661 aatgaacaga ctgctttttg gctattgttt gtttcgatgc gcttcattta attccttaat 3036721 atgctgaatg atctctttaa tgccctgctt cgcgtcgggg tatgtcgcat tccaatgctt 3036781 agcgagcgga ggcatgcttt tggctatatg ggtgtacaaa atccattgct tcacttcttc 3036841 ttttagctca tcgtttgttt caccaagcag aagctcagta tacttctcca gcaatccatc 3036901 aagctgctcc tgaagttttt gttccatttt ccatcttcct ttcgaaaaaa cagcaaggag 3036961 ctttctcaat tgaaagctcc ttcgctgcgt tatttatcca tgtgatgtga aagccgcttc 3037021 ctggacaatg catctgcccc tgccatgagg aatgcaaaga ggcgttccga agagcgggtc 3037081 ctgtgtaacc tgacagttca tagaaaacac attttgcaca agatcacaag tgatgacctc 3037141 ttccggacgg ccttctgcat aaatccgttt atcttttatg gccacaagat gatgcgcata 3037201 gcggcacgcc aagtttaagt catggagaac cataacaatc gtccggtctt ccttttcatt 3037261 cagctcaaac agcaaatcaa gaatttcaat ttgatgcgtc atgtctaaat acgtcgtcgg 3037321 ctcgtcaaga aggatgatat ccgtttcctg ggcaagcgtc atcgcgatcc aagcccgctg 3037381 gcgctgtccg cctgacaaag aatcaacggc acggtcagcc atgtcctcaa gctttgttgc 3037441 tttaagcgct ctttcaactg cttcctcatc ctcttttgac cactgcttca gccagttttg 3037501 gtaaggatat cttccttgct tcaccagctg atgcaccgtc agcccctctg gagccgaagg 3037561 accttggggc aggattgcga gctcttttgc gacttccttc gtcggaagct tggcaatcgc 3037621 tcttccttcc agcagcactg aaccgcctct cggcttcatc aggcgcgcta atgaacgtaa 3037681 aagtgtcgat tttccgcagc cattgctgcc aataaatacg gtaatttcac ctttgggaat 3037741 tgttaaattc aactcatcaa taataacggc atccccgtat cctaagctca gcgtttctgt 3037801 agaaattgca ctcataccca taaccgctcc tttttgctgg ctttttagca gcactatgta 3037861 ttgcacgttt tctatataca tgcttttaag tcaattgtca tcaatgcaaa tgattccgat 3037921 attcagccat ttgatatggt catatatccc tcattgtagc agaaaacact gactttgaaa 3037981 atcattttca attagtttta tggacataat tgacgtttat gggtttttta tcacaagatt 3038041 acttcttgat ttctctgatg gagccgtcct tcagcttcaa ttttaaatcg atatgatcat 3038101 aatgactgtc cagattaaat gctgccagca cactgtgtat cacttctgtt tcagccattt 3038161 ggtctgtcac ggaaagctcg ctcaaaatca ttttcatctc atctaacgct tcttctcctt 3038221 cctgattgac accggagagc ttatcctgta tttccgcttt ttcctgagtc ccgttctttg 3038281 tatagattcc ttcataacgg ttatgctcac catccccgta gctcacacga agcgaaaaat 3038341 tactgtaggg aacggacttc agctgggtga cggctgtatt ttctccttct gcctgatgct 3038401 ggtcttcatt gaaacggcag cccgcaatca gaaccactgc gagacataca gccccggctg 3038461 ctctgatcaa atgcatatgt ttcccccctg taggattcca tttattttag gtatatccag 3038521 agaatgaaat cctcattcag agaagaattg aaaaagccgg ggcatttaac gccacggctt 3038581 tttctttaag attcggtcat ttgtaaaaag gtttcggcgt cacgcacagc cagcttgatg 3038641 gcattctccc agaaatcgcg ctttgtgatg tcagcgccca aatgcttcat cgccaaatcc 3038701 tccactgtca tagaagccgt atcgcgcaat agcgccatat acttctcttc gaatgtgtct 3038761 ttttcttcaa gcgccaacgc gtaaatacca agagaaaaca ggtagccgaa tgtataaggg 3038821 aaattgtaaa acggcaccct cgtgatgtga aaatgaagct ttgatgccca aaaaagcgga 3038881 tgatattctt ctaacgcatt gcagtatgcc tctctttgcg cctcttccat cagctcattc 3038941 aagcggctgg ccggtaccac tccccgcttt cgttcctcgt agaatctcgt ttcaaataga 3039001 aatcttgcgt gaatgttcat gaagaacgca acgcttcttt gcactttatc ctccagaaga 3039061 acaagctttt cttccctcgt ctcggcctgc tggacagtcg cgtccgccac tatcatctct 3039121 gcaaacgttg aagctgtttc tgcaacgttc atggcgtagg aacggtttaa cggcctgacg 3039181 ttgagcattg cttcctgatg gaacgcgtgc ccgagttcat gcgcaagggt agagacattt 3039241 gaggcgcttc ccgaaaatgt catgaaaatc cgggattccc cgctgtccgg aaaactggtg 3039301 caaaagccgc cgactctttt tccgctcctg tcttccgcct caatccagcc gtcccgaaac 3039361 gctttttcag tgaatgagga cagctttttg ccaaacgttg aaaactggct ggtaatgata 3039421 tttgcggctt catcatacga atagaccttt ccgtcagaac cgatcggtgc ctcgacatcg 3039481 taccagctga gtttttcaag gccgagcatg gatgctttcc ggttcaaaaa ctgaacgaac 3039541 ggcttcttgt tttcagtgat gacctgccac atcgtatcaa gtgtttcttt tttcatcctg 3039601 ttaatttgca gcggttcctt caggacattc tcccagccgc gcgctttata ggtttcaagc 3039661 cggaatcccg ccaaatgatt cagcgtgctg ctgaaaatat cttgcttgct ctcccaagct 3039721 tggcggaaac gttcatatac tgtttttctg acagtacggt cttgatgatc catcatattc 3039781 tccgcctgac cgacagacaa ttgcttgttt tcaccgtttt cctcatacgg gatcgtcatt 3039841 ttcccgacaa ccatattgta taagtcactc caagcgtgat atccgtccac cgcaaggttt 3039901 ccgatcagtt tttccttacc ggggctaagc ttttcggcaa ccctctgtct tctttcattt 3039961 aatatgtaag aaacatcgcg caatcccggt tttgttaaca attcattcca cacgtcttga 3040021 ttaatgtcca caagtttatg atctaatgta acgagcgacg attgaaaatc tgcggaaagc 3040081 cgattcatga ggcctgatgc tctatagcct tttgatcatt gatattctgg gcctggaggc 3040141 aagcaacaaa agcgccggcc tgctgaagct tgacggatgt ctgttcgaat aaatcaagca 3040201 acgcggtcag cccttcagcc tcttcaggcg attcaggcac ctgaaacgca tcagtcctgt 3040261 cttgaaatgc acgcagactt tgtgacagct tctcaatata acctttgaat tcttccgatt 3040321 ggctcccgcc cttaaaaaat gaatcaagat cccatctttg gcctacccct tgcagcgcca 3040381 tatcacaaaa cccctttcct tctttcgttc tattatagaa caattctgaa ttattgtata 3040441 aaaatttcta ttacaggcgt catttcgtgt tcaggatagt acaatagctg tagcagttta 3040501 ataggagggt taggatgaat aaaaaaatag ccatcgtgac aggagcgtcc agcggcttcg 3040561 gtctgctggc agctgtaaag cttgcccgat catttttcgt gatagccaca tcaagacagc 3040621 ctgaaaaagc ggaacagctt cgagaattgg ctgcagcaca caatgtgtct gattctattc 3040681 acattacagc tctcgatgtc accgatgaac aatctatagt ctcattcgga aaagctgtta 3040741 gtgcttacgc cccgatcgat ttactcgtta acaacgccgg aacggcttat ggaggattta 3040801 tcgaggatgt gccgatggaa catttcagac aacaatttga aacgaatgtc ttcggtgtga 3040861 tccatgtgac aaaaaccgtg ctgccttaca taagaaagca tggcggcgca aagattataa 3040921 acgtgagcag catcagcgga ctgacaggat tcccagcgct gtcgccatat gtttcttcca 3040981 agcatgcatt ggaaggtttt tctgaaagcc tgcgtatcga gctgcttccg ttcggtatcg 3041041 aaaccgcttt gatcgagccg ggctcataca agacatcgat ctggtcaacg tcattatcaa 3041101 attttatgtc ggtgcctgct gacgattcag cctatcatca atactataaa aagatccttt 3041161 cctatgttca aaaaaacgga gaagaaagcg gagatcccca agaggttgcc gacctcattt 3041221 atcaattggc aacaaaacag cacataaaga atttgcgata cccgatcgga aagggcatca 3041281 agctcaccct gctgttccga tcgctttttc cttggtctgc gtgggagtct atcctgaaga 3041341 aaaagctatt cagctgatct aaattataat tattataatt tagtattgat ttttatttag 3041401 tatatgatat aattaagtca acagatcaca aggaggacgt tatcttatga aaactgaaaa 3041461 cgcaaaaaca aatcaaacat tagttgagaa ttcactgaac acacaattat caaactggtt 3041521 tcttttatac tctaagctcc accgtttcca ttggtatgtg aaagggcctc atttctttac 3041581 attgcacgag aaatttgaag aactttatga ccatgcggct gaaacagtgg ataccatcgc 3041641 tgagcgcctg ctggcgattg gcggacagcc tgttgccaca gtgaaagaat acactgagca 3041701 tgcatctatc acagacggcg gaaacgaaac atcagcatca gaaatggtac aagcattggt 3041761 aaacgactac aaacaaatca gcagcgaatc taaattcgtg atcggcctgg ctgaagaaaa 3041821 tcaagacaat gcgacagcgg acttgtttgt cggattaatt gaagaagttg aaaaacaagt 3041881 gtggatgctt tcctcttatt tagggtaaca aaaaagctga accttaatcg ggttcagctt 3041941 tttgtttttt cttagcttga actgctttct gtctgcttgg tcagtgttgc gttcaacgtt 3042001 ttcgtttttc cctttcgcag cacttggatt gttgttttat ctccgacttt taagtctttg 3042061 taaaggatct gacggatatc cgcactgctt tccacgtctt taccgtttag tttgacaatg 3042121 acatcctcag atttaatacc tgctttttct gccggcgaat ttgcttgaac ttcttttaca 3042181 taaacacctt tgcccaattg atctccaaac aggccgagcg tattttcctg ataggtttca 3042241 ggaacttgtg acatgtcaat catctgcacg cctaaaaacg gacggtccac cttcccgttt 3042301 tgcagcagct ggtcaacaat cggctcgaca tcattgcttg ggatcgcaaa tccaagtgat 3042361 tccacgccgc tttcgctcac cttcaagctg ttgatgccga tgacctggcc gcttgcattg 3042421 attaatgggc ctccgctgtt ccccggattg atcgctgcat cggtttgcag cacgttcatt 3042481 tccaccgtcc cctgtgttgt atccacatca attgtccggt tcagtccgct aatgatacct 3042541 tgtgtcactg taccggaaaa ctgctgtccg agcgggttac cgatagcgat taccttttcg 3042601 ccagtgcgca gctgtgaaga gtcaccaaag ctcgccactt tttttacatt cttgccgctg 3042661 atttccaaaa ctgccaaatc agtaatggta tcgctgccga caagcttggc agtttccgtt 3042721 tctccgttgt atagcgtaac agtcagcttg ttcgcgcctt caacgacatg gttgtttgta 3042781 atgatatacg ctttatcgct gtcttttttg aaaataacac ctgacccggt tccgctttca 3042841 ctttctgagc tggagcctcc tcccgtgccg aatgtgttat tttgagaggt ttggatattt 3042901 gagattccga caatcgtagg ctctaaatcc tctaccatat cagcgatgtt tgatgcgttc 3042961 gttatcggcg ccgttgtaaa attatcagac tgcacctgtt tatttgcgga agcggtttcg 3043021 gtcgcctgat tttggtctga cggcagataa ggcgcgatgc caagcatgag gcccccgccg 3043081 ataataccgc ctaaaatcgg gctcagccat gcggctctcc gtttcttttc ttttttcaca 3043141 gccgtttctt gcttttccat ttctaaagca gaagccgttt cctgccgtcc cgcttcatac 3043201 gacacaggcg cgtcaagcaa ttcttgttca gaatgtccaa tcagcttctg gttttctgta 3043261 ttctgctgtt ctgtatgtga aggttcagtt tgatgttgat cgttttggcc atcacgtcga 3043321 taatccatgt tcttacactc ctttaacggt tattcattta tcgttacata ttcatcgcat 3043381 gtacaagttc aattgtccca ataatgagga gaaaagcaaa gcaccaaaat agaatatgtt 3043441 tgatcatcct acatcttcct cgctcttttt ctcttccttt cttcccttaa ccatatcata 3043501 aacaaacatt gtgggataaa aatgaaaaga atatgtgaaa ttatgaaaat tgcctgccgt 3043561 atgttaaaac tagtttataa tgacgttgaa aggatgtgaa gagccttgtc atacaccatt 3043621 tatctagttg aagatgagga taacctgaat gaactgctga cgaagtattt agagaatgag 3043681 ggctggaaca ttacatcttt tacgaaaggt gaagacgcca gaaagaaaat gacaccgtct 3043741 ccccacctat ggattctcga tatcatgctg ccggataccg acggctatac attaataaaa 3043801 gaaatcaagg cgaaagatcc tgacgtgccg gtcattttta tttccgcccg agatgcggat 3043861 attgacagag tgcttggctt agagcttggc agcaatgact acatttcaaa gccgtttttg 3043921 ccgcgggagc tgattatccg tgtgcaaaag ctgctgcagc tcgtatataa ggaagctcct 3043981 cctgtccaaa aaaatgaaat tgccgtctcc tcgtatcggg tcgctgaaga cgcccgcgag 3044041 gtctatgacg aaaacgggaa tatcatcaat ttgacgtcaa aggaatttga tctgctgcta 3044101 ttatttatcc atcataaagg gcatccatac tctcgtgagg atatcctcct aaaagtgtgg 3044161 ggacatgact acttcggaac agaccgggtc gttgatgatc tcgtccggag actgcgcaga 3044221 aagatgcctg aattgaaggt ggagacgatt tacggtttcg gctacaggat gatgtcatca 3044281 tgaaaaacaa gccgctcgcg tttcagatat gggttgtcat atccggcatc ctgttagcga 3044341 tatcgatttt actgcttgtg ttattttcaa acacgctgcg agattttttc actaatgaaa 3044401 cgtatacgac gattgaaaat gagcagcatg ttctgacaga gtaccgcctg ccaggttcga 3044461 ttgaaaggcg ctattacagc gaggaagcga cggcgccgac aactgtccgc tccgtacagc 3044521 acgtgctcct tcctgaaaat gaagaggctt cttcagacaa ggatttaagc attctgtcat 3044581 cttcatttat ccacaaggtg tacaagctgg ctgataagca ggaagctaaa aagaaacgtt 3044641 acagcgccga cgtcaatgga gagaaagtgt tttttgtcat taaaaaggga ctttccgtca 3044701 atggacaatc agcgatgatg ctctcttacg cgcttgattc ttatcgggac gatttggcct 3044761 ataccttgtt caaacagctt ctgtttatta tagctgtcgt cattttatta agctggattc 3044821 cggctatttg gcttgcaaag tatttatcaa ggcctcttgt atcatttgaa aaacacgtca 3044881 aacggatttc tgaacaggat tgggatgacc cagtaaaagt ggaccggaaa gatgaaatcg 3044941 gcaaattggg ccataccatc gaagagatgc gccaaaagct tgtgcaaaag gatgaaacag 3045001 aaagaactct attgcaaaat atctctcatg atttaaaaac gccggtcatg gtcatcagag 3045061 gctatacaca atcaattaaa gacgggattt ttcctaaagg agaccttgaa aacactgtag 3045121 atgttattga atgcgaagct cttaagctgg agaaaaaaat aaaggattta ttatatttaa 3045181 cgaagctgga ttatttagcg aagcaaaaag tgcagcacga catgttcagt attgtggaag 3045241 tgacagaaga agtcatcgaa cgattgaagt gggcgcggaa agaactatcg tgggaaattg 3045301 atgtagaaga ggatattttg atgccgggcg atccggagca atggaacaaa ctcctcgaaa 3045361 acattttgga aaatcaaatc cgctatgctg agacaaaaat agaaatcagc atgaaacaag 3045421 atgatcgaaa tatcgtgatc accattaaaa atgacggtcc gcatattgaa gatgagatgc 3045481 tctccagcct ctatgagcct tttaataaag ggaagaaagg cgaattcggc attggtctaa 3045541 gcatcgtaaa acgaatttta actcttcata aggcatctat ctcaattgaa aatgacaaaa 3045601 cgggtgtaac ataccgcata gcagtgccaa aatagactgt agatgttttg cagtctattt 3045661 ttttatgtga aagaatagcc gttaaaatct ctgtaatttg ttttgagcgg ctgtttgcat 3045721 tgatgaaccc attttttctc tgacaaggtc tgcttcggat atttgacttt ctccactttg 3045781 attcctctgt ttcgcaagcg gctgatcatt tcgtccaatt ctctcattct agattcaccc 3045841 tttcgcttga gctttgacca ttcggtcatc tcaatttata atataaataa tacatgataa 3045901 aaaaacaagt tacaataagg ttaattttat aacagacggt gtgactatat ggtcatatcc 3045961 tagcaggcct ccgggctccg aaagggtgga accattgaag gaaaaagaaa aactgattat 3046021 tgaaacagcc ttaaaactat ttgcccaaaa aggatacaac tcaacatcag tccaggaaat 3046081 cgcaaaagaa tgcaaaatat ctaaaggcgc tttttatatt tattttcctt cgaaagaagc 3046141 gcttcttctc tctatgctga actactatta tgataaaacg tttacccgaa ttttaaatat 3046201 taaaacgaag ggcgacagcc ccagaacggc ttaccgtaaa cagctgaccg tcctctatga 3046261 aaacattctt gaacacaaag attttatcag catgcagttg aaggagggtt ctctgcctta 3046321 cacagaagaa gtggagcaat gcgcaaaaaa aatccgccag tcctcacttc aatttcatat 3046381 cgacagcctg ctgaacatct atggaaaaaa agcggaaccg tacactgctg agctttgttt 3046441 tttaatagag ggcatcagcc agatttacct ggaatgcatg attttgctcg ggtacactgt 3046501 gaagccgtct caattagctg atatcattat gaatcgaatt gatgatatgg taaaaggcat 3046561 gtctgaacga aacgataagc ctttcatcac attggaagag gcgagctctt tattcggacc 3046621 tcttacgcac ggacggcctg acccgctgac tgaatcaatt gtgaaaagcc tacgtgacaa 3046681 aattaacagc ttaaacacaa actcctctct tgaattatcg gagagcttgg acatacttga 3046741 agcagaaatg aagaaaaaaa caccgaagct ggcgatcata aaaggaatga ttcataatct 3046801 gacggagtct gaagctctcg ccaaagatgc ggaacagctt aaatatttat taaaacagca 3046861 acatatttag aagaacggct gcttaaaaag cagccgttct tcctattacg cctttggttt 3046921 taccatgtct tccggcttaa ccatttcgtt aaattgctcc tctgtcagca attcaagctt 3046981 caaagctgct tctttgagcg tcaatccctc tttatgggca agcttggcga ttttcgccgc 3047041 gttttcataa ccgatatgcg ggttcagcgc cgtaacaagc attaatgaat ttgacaggtt 3047101 ttcctgaatg gtttctttat taggctcaat accgacagca catttatcat ggaatgaatt 3047161 catgccgtca ctgagcagct gcacagattg caggaagttg taaataataa caggcttaaa 3047221 cacgttcagt tcaaagttcc cctgactcgc cgcaaagccg attgtcgcat cgttccccat 3047281 gatttgcgct gcgatcattg ttaacgcttc gctttgtgtc ggattgactt taccaggcat 3047341 aatagagctt cccggctcat tttcaggaat gacgatctcc ccgatgccgc agcggggtcc 3047401 gcttgcgagc catctgacat cgttcgcgat tttcattaag tcagccgcaa gcgcttttaa 3047461 tgcgccatgc gcataagtga tttcgtcatg gcttgtcagc gcgtggaatt tattcggcga 3047521 gctgctgaac gtttggccgg tcagcttagt gatctcttct gagacaagct ctccaaactc 3047581 tgggtgggcg ttgatacccg ttccgacagc cgttccacca attgcaagcg cacgcatttt 3047641 atctgtcgct tccaaaatca tttccttcga acggtccagc atgtgaaccc atccgctgat 3047701 ttcctgtccg agggtcagtg gcgtagcatc ctgaagatgc gtgcgtccga ttttgacaat 3047761 atcattgtat gcttttgctt tttcatccag tgtattgcga agctgatcaa gcgccggcac 3047821 aagctgctcg taaacagcca aaacagcggc aacatgcatc gcagtcggga atgtgtcgtt 3047881 tgagctttgg cttcggttca cgtcatcatt tggatgaatc gtttgatcag agttcttctc 3047941 ttttaataaa gcagtcgcac ggttggctac cacttcgttc atgttcatat tgctttgtgt 3048001 gccgcttccg gtctgccata cgacaagcgg gaagttgtca tcgtacttgc ctttgagcac 3048061 atcatcacaa accgctgcaa tcgcttctgc tttttcagcg tccagattgc cgaggcgttt 3048121 attagctaga gcagtgcttc gttttaaaat tgcaaacgcc ttcacaacac gcatcggcat 3048181 tttttcagaa ccgatcttaa agttctcctt gcttcgctgt gtttgggcgc cccaaaattt 3048241 atcagcagga acttttactt ctcccatggt gtctcgttca attctgtatt ccatttatgt 3048301 atccctccat aacggttgct tcaatagatc ataattcgcc aatgacacaa aaaatccttt 3048361 ttatttttcg atcttggcag attttaattt taattcaaga tatacgcggg aatcctttga 3048421 atatttgtat tttggatttg tcctgccgta ctcctttgat gtataagaga catcataatg 3048481 ctgttcaaat gatctaatga gctgttcaat ttcttcttgt tttccagcta gccttacctg 3048541 tgccacttcg tatcctccgc tttcataaaa aaacttactc catgaaatac tctaacacag 3048601 tatatcattt ttttaacagg aaaagataac ctctactaag gttttggata agaggtgacc 3048661 tcattggaac aaacagagtt taaggaatat atacacgata atttagcatt ggtgctgcca 3048721 aaattaaaag aaaacgatga tctggtgaaa aacaaaaaaa tgcttgcgaa cggactggtt 3048781 ttttactatc tctatttcag tgaaatgact gatgagaata aggtgtcaga agccattaaa 3048841 actttgatta aagatgagga gaccttaacg cttgaccagg tcaaaaaacg ccttgaccag 3048901 cttgacgcaa gacctgttga aactgcaaaa aaaacgattg aatcgattct caacggcaat 3048961 tgtgctgtgt ttatcaacgg attggataaa gcctatattc tgaccacagg aaagaaaaaa 3049021 acaagaagcc tgacagagcc gacaactgaa aaagtggttc gcggcccaaa agtagcgttt 3049081 gtagaggata ttgatacaaa tctcgctctg atcagacaaa gaacctctca tccgaaattg 3049141 atcaccaaaa aaatcatgat cggcgaaaac aagctgaagc ctgcagccat tatgtacatt 3049201 gaaggcaaag caaaaaagtc cgtcataaaa gaagtgaagg cgcggcttaa aaatatccag 3049261 ctggaagata tccaggacag cggaacgctc gaggagctca ttgaagataa taaatattca 3049321 ccatttccgc agatacaaaa tacggaaaga cctgacaaag tatcttcagc cctgtttaac 3049381 ggccgtgtgg caattttggt cgacagttca ccatttgtgc tgctggtgcc ggtttctctc 3049441 ggcatcctga tgcaatcccc ggatgactac tatgaacgct ggatttcagc atctcttatc 3049501 cggtcgctgc gctttgcttc tatctttatc accttgtttt tgtcatcgat ttatataaca 3049561 cttgtttcct tccatcaggg gctgctgccg accgcactcg ccgtcacgat ttcggcgaac 3049621 agggaaaacg tgccgttccc tccgatattt gaagccctgc tgatggaagt caccatcgag 3049681 ctgctaaggg aagccggact gcgactcccc aatccgctcg gacagacgat cggcctcgtt 3049741 gggggcgtag tcatcggaca ggctgctgta gaagcgaatc tcgtcagttc gattttggtc 3049801 attgtcgtca gtgtcattgc cctggcatcc tttaccgttc ctcaatacgg aatgggtctg 3049861 tctttccggg tgctgcgttt tatttcgatg ttttccgccg ctattttagg gctatacggc 3049921 attattttat ttatgcttgt cgtttatacg cacttaacga gacaaacgag ctttgggtct 3049981 ccgtattttt cgccaaacgg attctttagc ctgaaaaata cggatgactc cattatccgt 3050041 ctcccaatta aaaacaaacc aaaagaggtg aataatccaa atgagccaaa aacagactcc 3050101 actgaaactt aatacctttc aaggtatttc tattgttgca aatacaatgc ttggggccgg 3050161 acttttaaca ttgccgcgag cgctgaccac taaggctaat acgcctgacg gctggatcac 3050221 gctgatatta gaaggtttca tttttatttt cttcatttat ttaaacacgc tcattcagaa 3050281 aaaacatcaa tacccttcac tctttgaata tttgaaggaa gggcttggga aatggatcgg 3050341 cagcatcatc ggccttttga tctgcggcta tttcctcggc gtagccagct tcgagacacg 3050401 ggcaatggct gaaatggtga agtttttcct gctggagaga accccaattc aagtcattat 3050461 tttaacgttt atttgctgcg gcatttattt aatggttggg ggcttaagcg atgtgtcgcg 3050521 gctgtttccc ttttatttaa cggtaaccat tattattttg ctgattgtgt tcgggatcag 3050581 ttttaaaatt tttgatatca ataatttgcg tcctgtttta ggcgaaggcc ttggacccat 3050641 tgcaaactcc cttaccgtcg tttccatctc ttttttagga atggaagtga tgctgtttct 3050701 tcctgaacat atgaagaaaa agaaatacac gttcagatat gcgtctctag gatttctgat 3050761 tccgattatc ttatatatcc ttacgtatat tatcgttgtc ggagctttga ccgctcccga 3050821 ggtgaaaacg ctgatttggc cgactatttc tctctttcag tcctttgagc ttaaaggcat 3050881 atttattgaa cggtttgaat cctttttact ggtggtctgg attatccagt ttttcaccac 3050941 atttgtcatt tacggatact ttgccgctaa cgggctaaag aagacatttg gattatcgac 3051001 taaaacaagc atggtgatta tcggcataac ggtcttttat ttttctctct ggccggatga 3051061 cgccaatcaa gtcatgatgt atagcgatta tcttggctat atttttgtct ccctgtttct 3051121 gcttccgttc attctctttt tcattgtagc tctcaagagg aggattacaa caaaatgaaa 3051181 atccggattt tatgtatgtt tatatgcacc ctattgctgt ccggatgctg ggacagtgag 3051241 aatatcgagg aattaagctt agtgatcgga atagggctag acaagcctga cgatgaaaat 3051301 ttagagctga cacagcaaat tctcgtgccg aaaataatca gcgccaagga gggctcttca 3051361 tctgatccga cacagctttc tatcacaaag ggtaaaactg tccatcaaat gatgagaacc 3051421 tctgcattaa agcataagcc tacgttttca cagcatttgc gtctcattct gctttccaaa 3051481 agcgtgattg cggatcaaat tggaatggac gccattatta accagtttgt cagagacaac 3051541 ggaacaagga ggagttccta cgtctttatc accaacggcc gaactaagga tatatttaac 3051601 atgaatgatg aaggcgaacc cgcatccaac gtgatatatg atctgacaga gaataataag 3051661 gtgacgatca gaacgatgga gccagttaca ttgggggaga tctcagaaca cttaacctct 3051721 gacgattcat tcctcatccc tcatgtcggt aaggaaaacg gcaagctcgc gataaacgga 3051781 gcctctatca taaaaaataa attatggcac cgggacctca ccccgattga ggttcaaaat 3051841 atcagcttat tttcaggcac tgtcgaggga ggcgtcattg acttgaagcg cgatggccat 3051901 ctcttttctt atgaagtata ttcaagcaat cggaagatca agacggcata caaggacgga 3051961 aagttcaaat tcaccgttac ccgcaatatt gaaggtcgtc tatctgagga ctggaatccc 3052021 aatgaagact cgtttaagga ttcatatatt aaaagtattg aaaagacagt cgaaaaacga 3052081 gtacacgaaa cagtaacgtc atttattaca gagaagctgc agaaagagat caaagcggac 3052141 gtaaccgggc tgggaaacga ggtcagaatt cattatcctc aaaagtggaa aaagatttca 3052201 agaaaatggg atgatgatta tttcagcaat gcggaaatag actaccgggt caatgtgatt 3052261 gtcagagact tcggaacgaa aggcgcaaac aaatagcagc cgcctaattc acgagatgat 3052321 ttcggtgtgc gtacaccgcc gcctgcgtcc ggtcactgac atccagcttt gataaaatat 3052381 tcgtaatatg tgttttgact gttttaatcg taataaacag ttcctcgcct atttctttgt 3052441 ttgtctttcc ttctgcgatc aggcagagta tttcgagctc ccgttttgta agcgattcat 3052501 gcgggagcgc gttttcacct gagtggcgca gcctggataa tacttttccc gccacttttg 3052561 actccagctt cggctctccc ttgcttgcgg cgcggatggc atcggcgatt tctgccgctt 3052621 ttgaggtttt caacagatag ctgagcgcgc cagcttcaat aaccgggtac actttgtcat 3052681 catcaatgaa gctagtgagc acaataattt tcgggtcgga aagctcccgg caaatttgct 3052741 ttgtagcttc aatgccatcc atgccctcca tgacaaggtc cattaaaatg acatcaggcg 3052801 acagttccac agcaagccga acaccttcgc tgccgtccga tgcttcgccg atgacttcaa 3052861 tatcgggctg cgcctccaaa aaagccgcga gccccattct gaccatttca tgatcatcaa 3052921 tcaataatac tcgaatcacg ttcgttctct cctttttctt ccggaaaaat cgggaccttc 3052981 acttcgattt gagtgccttt tccttctact gaaatcactt cggcgacacc gccgatttca 3053041 cttgcacgtt ctttcataga attcaagccg tatgaggagg ctttcacctg gtccatttta 3053101 aagccttttc cattatcaat caccttcaga cggagctggc tgttctttat gcccagaatc 3053161 acggttactt ttgacgcttt tgaatgtcta aatacgtttg aaagggcctc ctgcacgatt 3053221 ctgaacaagt ggtcttcaac acccttggat atcgctgtgt cctgtatatc ccactcaata 3053281 tcaatcggct gcttttttcg gaactcgtcc aaaagctccg taaggccctc cttcagccct 3053341 tttccttcaa gggtaacagg ccgtaaatgg agcagcagcg ccctcatctc attttgggct 3053401 tcgcctgcca tatgctcgac catcctgatc cgcttgactg ttttgtcatc agcatccttg 3053461 acatgttcca gcacggctga tgtcatcatc gatatggcaa agagctgctg gctgaccgca 3053521 tcatgaagat ctctggccaa tcgctggcgt tcttctgaga taaccgactt cttcatttga 3053581 gcctgccatt ccgcacgttc attggaaagt ttctggaggg atgcgacttg aagctccacg 3053641 cgcttcgcca tttcgttcag ctgatcagca gccaggccga tttcatcatc accgagcggc 3053701 ggtatccgat aagcgaaatt gccgttttca aaggttaaaa tggattcaat taatgtatca 3053761 atccttgtct tcaaccggtt gccgtacata taccctgagg cgaaaccgac ggtcacgctg 3053821 atcagaagca aaatcaggat aaacggaatt ccgaaccagc ttgatgacag caaaacaagc 3053881 ggatcgagcc gatagtaaaa catcataaag gaaatcaggc aaacaaaaag gagcaggctg 3053941 attcccgttg tcatgcggat ggcgcgccat tggaggctgg caagcatttt ttttctcata 3054001 cgtacttcac atccacatca ccgataaata aggaaacgga cacttttacc cggcgctttg 3054061 actcgctaaa atcagttgac gcggcatata ccttcgtgct taatccgctt ttcttcgagc 3054121 cgatcagatt aatgtctcct ataaaaacag ccgagctgac agccacttca aggtccgatg 3054181 gtacataaat atcaacgtta ccaatgactc cgctaatgac gattgtactt tctccctcgg 3054241 gaatcatcgc tttagataaa tcgattttga tatcaccgat aaaaccagag acatttaaat 3054301 cgttcaggtc aaacggctgc ttcatcattt gcagctcacc gataaaaaag ctgcgcatgt 3054361 cgggatgttt tacatctttt ggcggctcat gatgttcttt tttattgaga ttgacctgtt 3054421 tctcattcgg ttcaaatatc ggcttccctt tgataagcct gtagccggcg taaatcagaa 3054481 atgcggcaaa cgcatagccg aataaattaa aggtgatgct gaagaggttt ttcaaaaata 3054541 gaaacgcggc aaagatatac atgacggagc caagccaatc acgggaatat tttttaagga 3054601 aatagccggc aatcagaaaa aagagcggcc aaaacagcag atcgcctatt ccgataattt 3054661 gcaaaaacat actgatgccg aataaagcaa tgatcaatcc gagaagctgt ttttttgtca 3054721 ttcctggtgt ccgcctcctt tcttctgcct agtgctaccg tatcgctaga tccccgctgt 3054781 ccgttttgat gtcgattgga tgccggccgc ttccttgcgt gcctgtgatg tgatgctgtt 3054841 ctttatgtcc tttatcagca aatgaatacg gcgaactgac gtcaccgctt gctgataaag 3054901 cattgactgc aaagctgcca ttttggggaa ggcttacatt agcatcaccg cttgtcagcg 3054961 tgacagatac gggaccggtt acctttttca atacagcatt aaaatctcct gaagtcattt 3055021 tcacatcaag agagcctgat acatgaacca gatttgcgtc ccctgaagct aaatcaatgc 3055081 cggctgtttt ggagacggta tttgaaatgg aaacatcccc cgatgatgcc ttcactttca 3055141 gatcttgaat gcggacgtcc gtcacgctcg tatttccgct cgcagatact gcgttcagcc 3055201 cggaaagcgc aagatggtca ttcccggcca cagacacgtc accgcttgag gttcgtactg 3055261 ccagatcacc tttataatca tacggaagcc tgacgataag agttgaacgg ttaaatccat 3055321 tcaaaaattg aaattctttt tcctttacgg tcagctccag ttttcttttg ttttcagtaa 3055381 caaataactt tcctgagtct cctgaaatgc ctgccgatat gtcacttcgt tcttccgcta 3055441 taatccggac atccttgcta tccgactcaa tgaccatgct gtcaatgtcc cgcggcgatg 3055501 cgctggctga atcagcttct gtgccattta tgaaacctag gcctgcagca aacacatctt 3055561 ttacgacgac ggcgaaaaaa accagaatac cggcagtgat caacagtttg ccaagcattt 3055621 ttttcattcg gtttcatcct tctcattcat tctattataa aggaaaagct tgcgaattga 3055681 tacgtgcgga agggaaggac ttgaccgcaa atccttcccc gttccgctta ttcatttgcc 3055741 gcttttgtct ggtctgattt ttgcagtgaa agtgtccgca ttttttcaat ctccgcttcc 3055801 acatcgtctg cgaattcttt acgtgtaagt tctgtgccgg cttccgctga ctttgaataa 3055861 ttcgcgcgga tttccatttc ttcaatacga ttttcaatac gtaaaaattc acgatacgcg 3055921 ctttcactgt caattttgtc aaatgtcgta ttcatatgct ctttagcttt cgccgcattt 3055981 gcccgcgcaa tcagcgcctg ttttttatcc tttacgtcct gaagctttgt ttcaagtgca 3056041 gccagctgct ctttcagatc agccagctga ctgtttgcct gttcatagga agctttatgc 3056101 tcagccgcct tcccttctaa atacttcatt tcagtcagcg cctttttcgc cagttcttct 3056161 tcacctgcgt caaatgcgag ctgtgcctga tttttccgtt tgccagccac ttcagcggct 3056221 tcttcatatt ttttcttaaa ttgataggca atcgtgtgct gtttcacaat tgtttgcttt 3056281 gcttttgcga tgtcgctttc catatcgcgt acatattgat tcagcatcac ctttggattc 3056341 tccattttat caagtccttc atgaactgac gcaacaaaca tgtctctgat tctttttaat 3056401 accatacctg attcctccta atatattgat attatttttt cttcaaaaat tcttcccatt 3056461 cgtcatcaaa gtgagattgg taggcagcag aagccggttc aggatcaaaa gatgatacac 3056521 cgttatcagc tgatccgttt ttcatcagct tccagccgta atacaccata gcggccgcca 3056581 atgcgattcc gacgacaaac ggaagtgagc agatgagcat aatggctccg ataccgccca 3056641 cgatgattcc cgtgatggtt tttcccgcgg caaacctttt gattcctgcg tatgtcatca 3056701 agctcccgat ggcgagcggg atgataaagc cgaagcttcc tcctccaaaa aagacggaga 3056761 tcccaaatac aattaataag aatccgccta ttgttttctt gtttattttc atgcagatcc 3056821 tcctttcgtt ttccttgtct tcatcttata caagttggaa gatatgcaaa acgaatcaga 3056881 gattgatttt tatataagac cggagtcgta tctcgcaccg gacccattgg cacaaaaaaa 3056941 cgccatgcac gaggcatggc gttttaaaac cctttacaga tgaacacttg cttccctttc 3057001 tttaattagg tcggaccttt ctgctttggc caattttgta aacagcaaga ttccgatacc 3057061 cgcaataatt tcgacaatcc caccgacagc gatcacttta cctgagccga aagcattagc 3057121 ggcatacccg caaatgacag ctccggcagg gatcgaaata tttgagatca tatgtataac 3057181 ggcgtaaacc tgcggctgat cctcactatc cacagacgtc tggataatcg tgtactcagg 3057241 aacattaaca gcactgactg cggcaccaaa ggtaaaagca gcgaaaaaga cgagcggcaa 3057301 aaaggtattc atcccggtaa taaagaaagc aaatccttca ataatgccgg cagtgacgaa 3057361 taacaagccg tacctgttta ccttgacttt cgccagcaca aaccctaata aaaacgcgcc 3057421 cgcggcggtg gtggccttta aaagcgagta tacgatcggc tggccgttta aatcttccgc 3057481 aacgtatacg gcagagagcg cttcccatgg ggcagccgcg aaattcataa agatacagta 3057541 aatggcgagc ggatataaaa tctggtgttt tctgacgagc ctaaagccgc gtttcagtct 3057601 tccgatatat gtgcctctct gtgtaacaac cgcagactct gattgagatt caaccgcagt 3057661 gtacttaata aaaagaacga gaaaacctga caccaaatag agcacaagtg cgataagcat 3057721 ggtataagaa ggactaataa atgtaagaaa agcgccgcat aatgtgacag ccccaagccg 3057781 gacaatttga gcggaggatt gcagcacagc gtttgctttt tgaatgccct gttcattgac 3057841 gatttgagga atcaaagcga tagaggcggg attgtaggca gctccagtag ctgaatgcac 3057901 aatcataagc gtcatgacaa accacagcgg agagaagccc gcaaaatgac atagagggat 3057961 aatcaaaaca atcgccgccc ttgtcagatc tgaaaagtac atccaaaatt tcagcgtggt 3058021 ctgtttcata aaaggccccg tcacaggcgc cagaacggct tccggcaaaa acgtgacagc 3058081 aatcaataaa gcagtgccga tcgcaccttt gccgtcataa attaaaaacc ataatattga 3058141 attaaatgcg aacatatcgc cggatatctt gactattctt gagaaaaaca gataattgaa 3058201 atttctcttc cagatgctat cactttcaat taaattcacc atccatcaga gccccccgtt 3058261 gcctattttt tacatctatt tattacaata tctcattttt ccatttttca gtcaataatt 3058321 cataaggttc attttttgtc gtaaaatggg aaattgacag agtgaaaaac aaaaaaagcc 3058381 ggcatgtatt tgaacacgcc ggctttcctt ttcacttttt atgattcgct gctgtttcgg 3058441 tcccgaaaca caatggcact tctttcatat tctacatcgc caataccgct tcttgcattc 3058501 acaacccggg cggcggcaaa gaaataatcg gacagacgat tgagataacg cagcactgtt 3058561 tcatgaatct cctccgattt catcagcgcc accactcttc gttctgcccg ccttgtaatg 3058621 gtgcgtgcga tatggagaag cgaagcacac tttgatccgc ctggaagaat aaatttcttc 3058681 agttccggcg cttctgctgt ataggcatca atgcgcgttt ctaaaaagga aacagattct 3058741 tccgttagtt tatagtcttt tctttctgtg acgattgcca gatcgcctcc gcagtcaaac 3058801 agctcatgct ggatggtcag cagctcggct gtcagatctt caaagccggg ctgcccggaa 3058861 agctctgcca aagcaagccc gataaagctg ttaagctcgt caatcgtgcc gtagctttcg 3058921 acgcgtaggc tgtccttgtc cgttctgccc ccgactaagc ccgtttgtcc cttatcgcct 3058981 gtttttgtat atagtttcat accctgaatc tcctttacag acttattcaa acaactcagc 3059041 agcctctttt atacattcag ctgtcccttt ctttatcaat tggttcagcc gctgttctat 3059101 gttttctgat tgctgagttt gagtcgcggc gatgagaata tcacctgtgc ctcctccgtc 3059161 tcccagcact ttcgtccgtt ctgcttcggc agccataaga gctttgatga agaattgatc 3059221 tgccgcatag ccgttaatca aaatccaaat cgaaaagccg gtctgaacgc atatgaaaac 3059281 ggataactct ccgtcttcat atgttcgata cacgaaacgg tcaagtcttt ctgaagaagc 3059341 catcgcacac gtctcctgca gttgaaaacc gctttctgaa agacaggccg taagtccttc 3059401 tatcggatct ggctgatctg gcagccgttt atggatcagc gtcctgctcc acgaaaaccc 3059461 tgcaccgata ggcgtggagg acaatgttcg aagcgggatt tccgtttgca gaagaatgtc 3059521 atcacgcccc gcttggagca atgcttcaaa tgggatagac tgccgcttca cgctatcttt 3059581 ttcaggctga atcacaatca tcggtttagg tgagctttga tgaaccaagg cggtgacatc 3059641 tgtatcgtac accgccttta tgctttgttc tgtaacagca tattccggtt tttgcttagg 3059701 cccggcggta ccgtttttca taaacatgag cccatcacag tacaggcttg cggtgttcag 3059761 atcatgaaaa acgctgacag ctgccaatcc gctttctctc gtcaggcgtt tgatcagatc 3059821 aagcaggtct ttttgataag ccagatcgag aaaattagtc ggctcgtcca aaaataaaat 3059881 acgcggctgc tgcgccaaag cttgtgccaa atacacccgc tgctgttccc ctccgcttag 3059941 ttcgcgaatc ggcttttgcg caaaatcggc cactcctgtt tgctccattg cttcctgtac 3060001 aatggcttca cccttttcag tctgctgtct gaacagcccc gtttggaatg gatatctgcc 3060061 aaaggctaca gtttcttcga cagtaaaggt gaaggcttga tccatttttt gcggcaggac 3060121 agccatgatt tgcgccagtt ccttcggttt atagtccgcc agcagttttc cggccagata 3060181 aaccctgcct ttcttggccg gcagcgtacc tgtcagcaag tgcaaaagcg tggtttttcc 3060241 gcttccatta gggccgagaa ttccaagaaa ttctcccttc tccactgtta agctgacatt 3060301 gttgattagg cggctgtcgc cgtatcctcc cgacagccct tctgccttca tcataagctt 3060361 ctccccccgc gatgctgccg aattaaaata agagcgaaca caggcgctcc cgccaaggac 3060421 gtaatgatcc cgatcggcag ttcaatcggc tcaatgatgg ttctggaaag cagatcggct 3060481 aaaacaagaa accctgcccc aagcaaggcg gacaacggca gtaaatgccg atggtccgtt 3060541 ccccacaaaa gccttgtgat atgcggaatc acaaggccga caaagccaat cgtacccgat 3060601 actgccacag cgcttcccgt caaaagagat ccggctatta aaatcatcat cttcctctgc 3060661 tgaacgctga ctccaagaag ctttgcttta tcttctccat atgtcatcac gttcagttcc 3060721 cttccgttta taatcaataa aatggttccc aaaagaaaaa acgggagaaa caaaataaca 3060781 tagctccagc ccctcattga gacgctgcca agcagccaat gcacaatcgg aagcaggttg 3060841 tctcctgtca aggcgatgat aagagaaata aatgcgccta aaaaagagtt ggtgatgaca 3060901 ccggtcaaaa tgagggtgga aacagacatc gaagcatgaa cgaggcggct gaagaaaagg 3060961 accgccgcca tcgtggccag tgccgcggct acactcaaaa ccgggagtgt aaaccctccg 3061021 atgacaggaa ggtgcaaacc taagaacaga gtcacaacag ctccgactga agcaccggat 3061081 gacacaccta gcgtataggg atcagcaagc ggatttttca acaatccttg aaaagcggcc 3061141 cctgcaatag aaagagccgc ccccacaagg gcggccagca caactctcgg cagtctgata 3061201 ttcatcataa tattagtgta catcggatca tcagaaccga tagagccgcc gaaaccttga 3061261 tgccaaaaga cacgaaaaac agcgggaata ggaatatgca ggctgccgca agaaattcct 3061321 aagatgatgc tcacggctaa aaatgagaaa ccaatgatat atgcggcata acgattattc 3061381 cttaaacgta tccgggtaaa tgctttccgc aagttcttcg accccttcga tcagacgggg 3061441 accggaacgt gtcacaagat cagggtccac atcatataca cgatgatgtt tcacagcatt 3061501 gatttcgctc cagccatcgc gtttttccac agctttcgct ttcacaccgt ccgttgtaac 3061561 aattgcatca ggattgagtt ttacgatcgc ctcgtctgtc atttgcaccc atcctgtctg 3061621 atccgcagct gcgtttttag catggatgac atttagcatt tcattcataa acgtatcttt 3061681 tccggttgta taaatgtcag gatcaggaga aacctcgata aatacgcttt tctcctcgtc 3061741 ttttgaaatg gttttcgctt tttcttgaat atcctttaga tctgatttca tgcttttcac 3061801 gagctgatcg gcttttttct ccgccccgcc agcttctccg atcatttcga ttgatttgta 3061861 cacctcggag aatgattgtg catcattgac agtcagcact gtaatgcccg cgtccttcag 3061921 ctgtttgatg gcatccgctg atgctgacat ggaagactca tgggccagaa cgagatctgg 3061981 ttttagagaa atgacttttt caacgtttac attcatatct ccgactttct caaccttttt 3062041 gacttccttt ggataggtat cgtttgtggt gacaccgacc actttgtcac caaggccgag 3062101 tgcgtatgta atttctgtgt tgctcggcat taatgaaaca atcttttttg gctctttttt 3062161 gatggttaca tcttggtttg acgcatcatc aatggtgaca gggaacactt ctgttttttg 3062221 ttttgccttt gaatccttct gatccgcagg attgccgcag cctgccagca taacagcagc 3062281 caacagaagc gcagcccata tcccggctcg ttttttcata atcttttcct cctaaacgaa 3062341 ctaaaaaagc atctctacga cggtaaagat gctgtaaaca acacaaaaaa gcctattgtt 3062401 tacacatcat ctgtcctcgc agaattcgtg ctgatcaaac aggcaggtat cctggctctt 3062461 ggcgcttggc caattacagt ggcgggaccg caccggcttt taccggtttc ccttttaagc 3062521 cggctgttgt tcacggaccg gcacctattt gacattcgta tccgtttttc ggagtaatta 3062581 tactatatga ctgacaggct tgtatatgtg tcctgaatga cttttcccca tattgtgtat 3062641 ggaagcaaaa tcctcgtaaa cactaaattt gatcttgtat acttaatacc atcatctatc 3062701 aaaaggaatg attcttatgg atttacagct aaaagaaaaa ctcgtcttaa tcaccggctc 3062761 gacgtccggt atcgggaaag ccgccgcaaa aagctttctg caagagggtg cggcagtcat 3062821 tgtcaacgga cgcaaacagg agactgtcga tcgcaccatt gaagagcttt ctggctatgg 3062881 aacagtgcac ggtgctgctg ccgatttgtc aaaaacagat gaagcagcgg cttttatcga 3062941 aaaagtaaat gaaatcggtg atatcgatat ccttgtcaac aaccttggtt tcttcgaggt 3063001 aaaagacttc gccgatgtga cagatgaaga gtggaatcaa tatttcgaag tgaacgtgat 3063061 gagcgccgtt cggacaagcc gtcacttcct tccaaaaatg cttgccaaaa acagcggccg 3063121 cattttaaat attgcaagtg aagcaggcgt caaaccgctg ccaacgatga ttccatactc 3063181 aatgacaaaa acggcactga tcagcctttc aagaggaatg gctgaaatga caaaaggcac 3063241 aaatgtgacg gtcaactcag tgctcccggg acctacttgg acagagggcg tggcctccta 3063301 tatggaaggc gccgcacaag cagccggaca ggatacagat acatttatca aagactattt 3063361 caaggtcaat gagccaacct cacttattca gcgatacgcg acagcagaag aagtcgccaa 3063421 cacaatcgta ttcctcgcgt ctgacgccgc atccgccatt aacggcacgg cacagcgtgt 3063481 ggaaggcggc attatccgtt ctctgtagta taaaaaaacg catccgtgtt tcggatgcgt 3063541 tttttttata cgtctccagc aaatggtacc ggctgatatc cgcctgtttc cagttgtgct 3063601 gaaaacaacc ctccagcgtg aggctgctcg tatctctctt tttctgtcat ttgttctgtt 3063661 gccgttgtaa tgtaaagggt ttttaagtct ctgccgccga acgcgcagca cgtgacatat 3063721 ttagccggca cgctgattga attgatttct tttttctgaa acgggtcaat gtgaacaacg 3063781 cggctgccgc caaacagcgc cacccacagc atgccatttt ggtcaattgt catgccgtcc 3063841 ggcaatccgt ctgactgatc aaaacgatag acaggttctg gattcgaaac atctccgctt 3063901 tgaggatcat agctgtaacg tacaatctcc tgggtcggcg tgtcgatgta atacatcaaa 3063961 ttccgctcgc ggtcccaatc caaaccgttt gaggtggaga cttgatcctt gattttgaca 3064021 agactgccgt ctagattcaa acggtacagc gacgcctgtt tttgctcgcc ttccatgctc 3064081 gtcgtccccg cccaaagcct tccgtacggg tcacatttag catcattaaa tctcaggctc 3064141 tcatgcatgt ccttcggctg tttaattttt tccaagctgt catcccgaag atgatacagg 3064201 taaaacccgt ccttcatcgt cataatcagt tcatcctttg aatatttcgc aagcgccgtc 3064261 acaaaggatt tgaatttgat tgatcggttg attttttctt cagggtcaaa gatgtggagc 3064321 tcgctcccca ggatatcaac ccaatataag cggccgttct cttcatccca taacgggcct 3064381 tcaccaatca ctgcccgagt gtctgcttcc aatactgcat ccatgtgtta cacctcttta 3064441 gcttcagtct atatattgtt attcccggca aagaggtgtc caaaccactt gatgtttatt 3064501 gttttttaaa aaggatggta atgaccgttc caatgttcgt tctgctgttc acatggatcg 3064561 ttccgttatg cagatggaca agctccttgg caatcgcgag cccgagaccc gttccggcag 3064621 ttgaatcttt tgtgttcgtc cctctgtagt agcggttaaa caaatgggtg atcgtttctt 3064681 catccattcc tttcccattg tccttcactt ttaaagaaat atgatttttt gtttgctcca 3064741 gaatgacttg aatctctgtt cctttgccgt tgtgcttcac ggcattccca aggaggtttt 3064801 ctaatatgcg cctgaaccac gcttcatcaa gggcaaattc aatatgctct tctttggata 3064861 caaacgagat atcatagcct tcagaaaacg gatttttctt aaaatcctca atgacatttt 3064921 taaaaaacgg gataaggcta gtgagctttc tctcaatagg aagagcatca tttttcaggc 3064981 gatacgttaa atttaagtct tcaatcagct tagacatgta ttcagatttt tctctgacaa 3065041 cctgccccat ttctttcact tcttccggcg accagtcata ctgcttcgac tcgagcatca 3065101 tgctgtagcc gtaaatgctg ctgagcggtg tttttaagtc atgtgacaaa ccggcaatcc 3065161 attcttccct tgtcgcctgg attttttctc tgtttctttt atcccttctc agcgtttcag 3065221 tcagctgatc cattgattca aatatctcac cgaagaagcg gtacggctgt ttgatttttc 3065281 cctttttatt tttgctgaca ggacggcctt cccggtttct gggctcctca agcttccctt 3065341 ttgacagatt gaccagccat ctaatcgtgt gaaaaatcgg cagcccgaat cggaacatat 3065401 accaaacggt catccaaatg atatacatga acaaaacggc catcacgaga aacatcgctt 3065461 ttaatacaac cttcaggaat gatttgttaa actcctgatc ggttacatag actgggttcg 3065521 gcaccgtagc gaccatccat ctgtctttat tgaggatctt aacggaaatt tcccgcttat 3065581 agttccaagg cttagagctg tatttaagca gctccagctg gttcatcgtt tttctctcgc 3065641 tttttgtgct gttgatgctg tcgagaatct ttccattgct gtctaacagg taaatggcgc 3065701 cttttttccg tttaatatag tcgatggtac tagacttata gtgcgctagt gagtctatct 3065761 tttgttcacg cttttcaacg gaagtcagga gctgttcact ttttgatttc cagccggaca 3065821 atagaagata cgacttatct tcaatattga tggcccaata attcagttta tagttatgaa 3065881 gctttttggt tttataaata gacaaaagct ctttcttggt ataggtgccc ggcacgtctt 3065941 ttggcacgcc gtaggaataa tcagtgtttc cttccgaatc aatgatttgc atccagccgt 3066001 gctgtttatc aacagatttc ttcaggaaat tatccacttc ccatgtcccg tcttcgttta 3066061 catcgagata tgcctcaagt gtgtcggtcg ttgctttcgt cagccctgaa ttggattccg 3066121 catcgctaaa acgggcgtct aaatagaaaa acgatgcaac aagcataacc gtaagcagca 3066181 ggatcacaat cagcatctgg ccgaaaaagt gaaacaaaaa cttccatctt aacctcatga 3066241 ccgcttgcct tcaggatttg ggataaaacg atagccgaga cctcgaacgg ttacaatata 3066301 ctccggattg ctcggatcgc gctcaatctt ctccctaagc ttgcgaatat gaaccatgac 3066361 ggtgttgttg tcaccgtagg aaggatagcc ccatactttt tcatatattt gatctttgga 3066421 aagcaccacg ttagggtgtt cacaaaaata ctgcaaaagc tgcagaagct gggctgaaca 3066481 ggcaacggct tccccgccta cgatcaactc ggcattttgc ggagaaaaag taaagtaatc 3066541 atatgtgtag gtttgatttg aactcgtttc tttcgattga tatgtacgct tgagatgcgc 3066601 tctgatccgc gccgctaatt ccagcggatt aaatggtttt gtgatatagt catcagctcc 3066661 aaccgcaaag cccgataatt tgtccgcgtc ggatgatctt gccgtcagga aaaaaatcgg 3066721 agcgtctgaa tactctctga tcaatgtgca ggcttcaaaa ccggacattc cgcccatcat 3066781 gacatccagc acaatcaagt caaccttatt ggccttcaca acgggaatcg cttcttctgc 3066841 gcttgccgca tccagtatat ttcgataacc ttctttttcg agaacgcgtt tgatcatgtc 3066901 cacaatcgct ttctcatcgt ctacgattaa aattgacgca ttttccactt ttatgttcct 3066961 ttctgtcact gtttttttca tcttatcatt atatcgttta tttatggtac atttttgaat 3067021 acattggagc cttggcaaat caaaacagca aaaaaggagc aaacaagcgc tcccttttga 3067081 tgttttttca tatgaaaata ttatgagttc tcatctacca tgtacaaaat aaactcccaa 3067141 aaccccggta catcctgaca taaaagcata tcagcctttt caaacatttt gatcttcagc 3067201 tcttgctcta aatcttctct ttcttgatag gacgtattgc tgagtttttt tctgatcatc 3067261 ggtgaaaagc atgcaatcag gtgctcaatg tcataagtct cgtctttttg tttctttttt 3067321 tgttcaaact ggccgtccac agcttacttt tccccctttt tttgcgccgc taactgcttt 3067381 ctgatattct ccagcccctt tttatgaatg ttggagatgt tttgtcggga ctcccctaat 3067441 gaatctgcaa tctcctgcat cgtggcaccg tgaagataga ctttcgtcag cacacttttt 3067501 tgtttgtcag tcagcttctg gatcgcttgg tagagctggt aatcctgtac atgctggctc 3067561 aaatcatcct gcctgtctaa aaattcttca aatgcatcgc tacctgtttc ggaagaaagc 3067621 cgatctcccg cctccggatg atcaaccgtc agtggatacc gtttttggtt tttgcgaacc 3067681 cgcttatcaa aatcaataga aaagatgcga atcattgaat tcatatactt gacgatgcgg 3067741 atttctttat aaaattgctt aaatagctcg tccaatgatc ttgcatcttt ttcgttaggg 3067801 ctttccatta cgtttttgaa caaacggtaa tgctgaggat tgctcaaaaa atgcttcacg 3067861 atgggatgct tcattatctc cttacatttt gaccgtaaaa gactttgata gtccatcaaa 3067921 ccgcctccct actaaattaa atgaaggaaa gcaaaaaaaa gtaaactact actttccgcc 3067981 tagtgtcttc caaaatactt tgcagcagtt tacgttttat cggttttcct cacttacata 3068041 catgactgca gaaaaagaag ggaggtattt tcctatggat caggttttta tagaggaagt 3068101 cgtaaaacag atcggcaatt tggggtttcc cgcgctgatt gcaatgtatc tgctgacccg 3068161 attcgaaaag aagtttgatc aactaataga actaatgaca gaactgaaag atcatgcaaa 3068221 aaaataattt ttcaatcgaa gttgactttt cactggtttt tttcacttaa caaaacagaa 3068281 gggaaaacga aaggcctttc accttctctt tctgctatca catttaaatg taaggaggaa 3068341 acatttcatg aaaaaacaaa atgacattcc gcagccaatt agaggagaca aaggagcaac 3068401 ggtaaaaatc ccgcgcaata ttgaaagaga ccggcaaaac cctgatatgc tcgttccgcc 3068461 tgaaaccgat catggcaccg tcagcaatat gaagttttca ttctctgata ctcataaccg 3068521 attagaaaaa ggcggatatg cccgggaagt gacagtacgt gaattgccga tttcagaaaa 3068581 ccttgcatcc gtaaatatgc ggctgaagcc aggcgcgatt cgcgagcttc actggcataa 3068641 agaagctgaa tgggcttata tgatttacgg aagtgcaaga gtcacaattg tagatgaaaa 3068701 agggcgcagc tttattgacg atgtaggtga aggagacctt tggtacttcc cgtcaggcct 3068761 gccgcactcc atccaagcgc tggaggaggg agctgagttc ctgctcgtgt ttgacgatgg 3068821 atcattctct gaaaacagca cgttccagct gacagattgg ctggcccaca ctccaaaaga 3068881 agtcattgct gcgaacttcg gcgtgacaaa agaagagatt tccaatttgc ctggcaaaga 3068941 aaaatatata tttgaaaacc aacttcctgg cagtttaaaa gatgatattg tggaagggcc 3069001 gaatggcgaa gtgccttatc catttactta ccgccttctt gaacaagagc cgatcgaatc 3069061 tgagggagga aaagtataca ttgcagattc gacaaacttc aaagtgtcta aaaccatcgc 3069121 atcagcgctc gtaacagtag aacccggcgc catgagagaa ctgcactggc acccgaatac 3069181 ccacgaatgg caatactaca tctccggtaa agctagaatg accgtttttg catctgacgg 3069241 ccatgccaga acgtttaatt accaagccgg tgatgtcgga tatgtaccat ttgcaatggg 3069301 tcattacgtt gaaaacatcg gggatgaacc gcttgtcttt ttagaaatct tcaaagacga 3069361 ccattatgct gatgtatctt taaaccaatg gcttgccatg cttcctgaaa catttgttca 3069421 agcgcacctt gacttgggca aagactttac tgatgtgctt tcaaaagaaa agcacccagt 3069481 agtgaaaaag aaatgcagta aataaaagac ttgcggcttg cagagagcac tcgttctctg 3069541 caagccttca taaggagctg aaccagtgaa acatcaaaac ccttcaaaac gcttattgcg 3069601 gctctccata aagtacttgc tggccgcagc agcagtggtg ttgacctatt ttgctgtcat 3069661 ctatatattg ttttctttag cgggaacgag ctaccgctca gcagctcatg tcctgctttt 3069721 tgccgtggta ttccttgttc tcggattatg ctttgaacca tttgaacggc tgatgataca 3069781 tagctttaca tttttcaaga caggaaaacg tctattcatt ctccttgctg gcatcgtaca 3069841 gctgctgttt ttgtggatga ctgctcatac aacagaccaa ttgatcagcg acatctggct 3069901 gtccaccaca gaagaaatga ttgtcgcagc cgtttttttg attttagaca aatgcaactc 3069961 ggctcttccc agctaaaaaa agaacgcatt ccaattggat gcgttctttt tattcatagc 3070021 gaagcgcgtc tacaggctga agcttcgaag ccttgataga cggaagcaag ccgaagataa 3070081 tgccgactgc cattgaaaag atgagtgctc cgacaacagc tggaatggag acgataaaag 3070141 gcatcggaaa aatgaccgtc agcagcttgg cgatgccgaa gcccgccagc acaccgagta 3070201 ttccgccaat gcttgtcagc acgacagcct cggttaaaaa ttgaaataaa atcacacgcc 3070261 gcttagcacc gagcgctttc ttaattccga tttccctcgt gcgctccgtt acggaaacga 3070321 gcataatgtt catgacgccg ataccgccca ccaaaagtga aatactggcg ataccgccaa 3070381 gcagcaatgc aaatgactga ttaaaggact ccacttcctg cgcgatctcc tgaagatcca 3070441 ttacactgta ctctgctttt tccagctcag cttctgacag tccctgattt aaaagatctg 3070501 cagccattac acccgcttct tggatatgct cagaagaatc agcctgcacg gcaatctgcg 3070561 ttggcgcgtc aaatccttca ataagcggcc acactttttt cggcacgtac aaaaccgggt 3070621 tcgcatagtc gccttcaaac atgctttcct gttgattttt ttctttaaaa acacccacga 3070681 ccttaaacgg cacaccattc atctcaatgc ttttatgcag agcttctccg tctggaaaca 3070741 gttcatctct gacagcttca ttgatcatca ctacttggtg tgtgctgttt aaatcgtttt 3070801 ccgtcagctt tctcccttcg gttattcgga ttggaaacat gtcgaagtaa tcatcgtcca 3070861 ctccatacac ttggggatac gaaacgttag ttaaatgaaa aacgctcgcg ccttctgaca 3070921 agtaatataa ggataatcct ttgaccatcg gatctgattt gatcgccttt actgtttctt 3070981 ccgctacagg cggcgcggac gcatacgaca cctgagggcc gccgctctcc tcttctccgc 3071041 cagacggctg gtagacaaca ttgatggcgt tgtttcccat gccgatcata ctttgcttta 3071101 actgctcact ttggcccttc agcattgaaa caatcgcgat gattgccgct atgccgataa 3071161 tgacgccaag cattgtcaga atcgatctta atttatgaga gaaaatggat tgaaaggaga 3071221 ttcgaatatg ttcaagcatg gctgatatcc cctctctcat ctaataccaa ctctccgtct 3071281 ctgataaaaa cggttctgtc agcttttttg gcgacgtccg ggtcgtgggt tatcataata 3071341 atggtcttgc cttcccgatg cagttcagaa aacagtgcca aaatttgttc acttgatttg 3071401 gtatcaagcg ccccggtcgg ttcatcagct aaaataaacc tcggctgatt gacaagggcc 3071461 ctcgctatcg ccacccgctg cttttggccg ccggacagct taggcggttt gtaggagacc 3071521 ctgtctttta atccgacttt ttccagcgct tcatatgccc gttgccttct ctcttttttc 3071581 ttcactttat tgtagatcat cggcagctcg acattttgca gcgcggtgag acgcggcagc 3071641 aaatgaaaag tttgaaacac aaacccgatt gattcattgc gaatttcggc taaagccccg 3071701 tctttccctt tcaatatatc gatctggtca agcgtatagg ttcctgaggt tggcctgtcc 3071761 aaacagccga taatattcat taacgttgac tttccagaac cggaaggccc cataatagct 3071821 aaaaactccc ccgcctgaac ggtcagattg atatgtttca agattggaac ttcttctttt 3071881 cccagcttgt acgacttcga aatattattc agtgtcagca ttgactgtaa cctgctttcc 3071941 ttccttgacc gcgggatcag gatagatcac ataatcttcc ggcgtcaggc cgctcttaat 3072001 ttccaccatg tcattttcat cagtctctcc gatttcaaca ggctgcttaa ccgctttgtg 3072061 attctcatca gctttccata cgtacggttc gccgtcatcc tgaatgacca tgtcggacgg 3072121 cagcttgatc gtgtccgcat cagcattatc actcatcact tcgatgttga catgatagcc 3072181 gacttcaaga cctttatggc tgtctaataa aatggtgaaa ggatagttag aggactgggg 3072241 attcatttct tcatcagcaa agctttctga ttcttcaccc tcgcctgctc ccgctggaag 3072301 cttgccgatc gaggtgacct ttcctttcca ctcgccctca ccgcctgttt tcagcgtgac 3072361 cctgactttg ctgccttttt tgatcgtgtc cattaacagc tcattgattt ggcttttgac 3072421 cagatatttg cctgtcgaaa caatctggat atacgggcct gctgcctggt cgcctgttgc 3072481 accgtcagcg atatcctgat tgacgctttg aacgattccg tcatgcttgc ttgtaatgac 3072541 attggaacct ttgtttttcg tcaggccagc cagttctttt tgatgctgct tcagttcaag 3072601 ctggcttgtt ttcaaatcga aattggtttg atcaagttca tcttgaagct ggtttttctc 3072661 ttcttttcct gcaactttca gctttttttc cgtttccgtt attgattttt gcaaacggtt 3072721 gatttgcaga tttgtcattt caatttgcaa attggcttgc tccacttcat cagaatgatc 3072781 ctcgccctca tactcaaaaa gcttatcgcc ctttttaacc tgatcgcctt ctttgacgta 3072841 tgttttttta atgctgcctt tttctgaatc tatgtatact ttctgctgtt tctcaggttc 3072901 aacctttcca gaaaacgttt ggcctgattc tgaatctcct cccatgtata ccgcgaccga 3072961 ttcagcatag ggctccgatg atacggcaac ttggttcatg tgagtaaaaa agtaaaaacc 3073021 gccagcgccg atcccagcca atacaagcac accggcacat atcgcaccgc caataagcca 3073081 ttttttcttc ttggacacaa cgatctcctc tttctgtaaa ctatgtaata ttttcgaaac 3073141 attctaacca atattatcta ttaattcaaa aagacttgca atccttttat tgaaatgacg 3073201 gaatcaaata gaaaaattgt attttcaaag ccgaataaaa aaaatcccgg cttcaaaccg 3073261 ggattttttc atacagtaac tagctctttt tcatttttaa tcaagtcata tgtcaagcat 3073321 acaggtttat ttgtacgggg atcagtcacg atttcggcat caatctgaaa tacctgcttc 3073381 aaaatgtctg gtgtcatgac ctccagagca gttccttcct tgatgaccgt gccttttttg 3073441 agcgcgatca tataatgaga aaaacgagct gcatggttaa gatcatgaat gaccattaaa 3073501 atcgtccgcc cttgctcttt gttgagtctg tcaagcagct gcagaatttc aagctgatgt 3073561 gcaagatcaa gatacgttgt aggttcatcc agcagaagca gttccgtccc ttgcgcaagc 3073621 gccatggcaa tccacacacg ttgacgctgt ccgcctgaca atgcctcaat cggccgttca 3073681 gcatattcag ccatgcctgt ttcttcaagc gcccatttga taatccggcg gtcttcgtca 3073741 tttaatctgc cgaatcctga ttgatgcgga aacctgccgt acgacaccaa ttcgtgcact 3073801 gttaggccgc tcggcgcttc aggtgtctgt ggaagaatcg ccatatcttt tgcaatgtcc 3073861 tttgtagaca ttttatgaat cgctttgccg tttaaataga cggcacctgc atgtgaacgc 3073921 ataattctgg acattgtttt taaaatcgtt gatttcccgc agccgttcgg gccaattaag 3073981 gtggtaattt tccctttagg aatcgatata tttaaatcct ctacaatcac cctgtcgcca 3074041 taaccgattc caagctgttc cgttgataat gaattcatat tcggccccct cctctaattc 3074101 gctttcatca ataaataaat aaagtaaggc gcacctagca cggaaatgac aagtccgacc 3074161 ggaatttctg atggtgccaa tacatttctc gccagcgtat cagcaagcaa aaacaggaat 3074221 gagccgatga aggcggagac cggtatcagc gtctggtgac gtggaccggt cagccttcta 3074281 gccacatgcg gcgcgatcaa tccgagaaac gcaatgcccc ccgcagctgc cacgcatgaa 3074341 gcggcaagag tgaccgctgc cagaagaaga atccgtcttt ccttttcaac agcggtgccc 3074401 agcccggtcg ccaattggtc tccgagctgc ataatgttca aatagcgtgc cttatataaa 3074461 gtaaacagaa gcaagatcac aatccaaggg agaatcgccc agatcatatt ccagttcgcc 3074521 ccccatattg agccggatat ccaaaccgcg gcttgcataa aatcatgagg gtccatcttg 3074581 agctgaaaaa tcagcaacag ggcgttgaat ccggcattca cccctatgcc gactaaaatc 3074641 agccgaatcg gtgtcacgcc ttttttccat gccagaatat aaatgagaaa cgcagcgagg 3074701 attgctcctg ccaaagcact gaacggcagc ataaatgttc cgaaaaagct aagatctgaa 3074761 gctgaccctt gaaaaaagta tataaaaagc actacagcaa gtgaaccgcc ggcgttaatt 3074821 ccgagaatac caggctcggc aagttcattt tgagacacgc tttgcaaaat ggctccagct 3074881 acggagatcc ctgctccaac aagcaaagaa aggatgatcc ggggcagcct gaactcaaat 3074941 aagacaagtt catcacgcgc cgttccttgg ccgaaaaaga cctgaagcgt tttaagcggt 3075001 gcaattttga taacgcccaa attgagactg ataaaaaaga ccaccacgat aagcaaaaag 3075061 gtcacagcca ttacaatgag cggtttgttt gtttttgttt tcattacagc cctctccttt 3075121 cacgacgtgc caaataaaag aaaaagggaa cgccgataag agaagtcagc gcgccgacag 3075181 gcgtttcaaa gggcgcattt acgagtctgg ccgctatgtc agcaaaaaca agcaaaacag 3075241 caccgagcac cgccgagcaa ggaatgatcc accgataatc cacaccgacc aaaaaacggg 3075301 taatatgcgg aatgatcagc ccgataaatg caatggtgcc ggcaatggaa accgcagctc 3075361 cggtcagaat tactacaata agcatgccaa ccagtttcac cgctgatgta tattgtccaa 3075421 gcccttttgc cagatcgtca ccgagactta acactgtaac agaccgggcg atgaaaaacg 3075481 cgagcgttaa accgacagcc cctgcaataa gcaaaagctg gacccccgac catttcacac 3075541 ccgctacccc gcctgcgtac caaaagctga tatcctgagc gacatcaaag cggattgcaa 3075601 tggcagttga aatgccggta aagaaataag taactgccgt acccgccaga gcaagcttta 3075661 caggcgtaag tccgcccctt gaaaacatgc ctatgcccat taccgtcgat gcccccagcc 3075721 ccgctcccgc aaaggaccat agcacaagcc ccattgcaga aagtccggga aaaaaggcaa 3075781 acgcaatcga aaccgcaaac gcagagcctg atgtcacacc cataatcgaa ggctctgcca 3075841 aagggtttct cgtcatcccc tgcatgattg ctcccgacac tgccaacaat gcgcctacaa 3075901 gcgcggcagc cgccgttctc ggaagccgaa gatcatgtat aatttggtga gatgtctttg 3075961 tcggctgata atgaaaaatg gcctcccata cagtgcgcaa atgaatatcc gctgcaccta 3076021 gggatatgga taaaaatgcg ccaaggcaaa gcaggcatag acctgcgata aggacgatga 3076081 ccgcgccata tgtccttgac gtccattgga tttcttctga tgcagtccgt atatttttat 3076141 gttgactcaa ctgccgtact tcctttctgt tactgataat gattatcaat tgctgtttca 3076201 gtatatcact tttttcagct gatttaatag agtgttttga acaaaaatga aaatgcattt 3076261 gcaaaaatat cgtgtcaacc ggcacttgca gtggtataat cacagatgat aatgattctc 3076321 tttttcatct atcttttaga aagaaggtat gagatatgac ccatatatac aagaaactcg 3076381 gagccgcgtt ttttgccctg ttattgattg cagcgctggc agcctgcggg aataactcag 3076441 aaagcaaagg ttctgcctct gattcaaaag gcgcagaaac ctttacatac aaggctgaaa 3076501 acggaaatgt aaaaatcccg aagcatccta aacgggtggt tgtcatggca gacggctatt 3076561 acggctactt caaaacactc ggcatcaacg ttgtaggtgc gcctgagaat gtatttaaaa 3076621 acccttacta caaaggaaaa accaacggcg tcgaaaacat cggagacggc acttcggttg 3076681 aaaaggtcat tgatttgaac cctgacctga ttatcgtctg gacaacacag ggcgctgata 3076741 ttaaaaagct tgaaaaaatt gcgccgactg tcgcagtaaa atacgataag ctcgacaaca 3076801 tcgaacagct gaaagaattt gcaaaaatga cgggaactga agataaagct gaaaaatggc 3076861 tggccaagtg ggataaaaaa gttgcggccg ctaaaacaaa aatcaaaaaa gcggtcggtg 3076921 acaaaaccat ttccattatg caaacgaacg gaaaagacat ttacgtattt ggtaaagact 3076981 ttggaagagg cggaagcatc atttacaaag acctcggcct gcaggctaca aagctgacaa 3077041 aagaaaaagc cattgaccag gggccaggtt atacaagtat ttcattagag aagctccctg 3077101 acttcgccgg agattacatt ttcgcgggcc catggcaatc aggcggtgat gatggcggcg 3077161 tttttgaaag ctccatttgg aagaacctga atgccgttaa aaatggccat gtatacaaga 3077221 tggatccgat cggattctat ttcacagacc cgatttcatt agaaggacaa ctggagttta 3077281 ttacggaaag cttgactaaa taaacaaaag agccgcctgc ccgcggctct tttgcttatt 3077341 tataaggaac ggctcaattt gaatcatatc ggatattttc tttgagccat tcatattaag 3077401 ctgcatcctc atcacgatca gtttttttat gctggagaga ctgaaaaacg ttttttgcat 3077461 atttaacgaa cggattccta acaggagaaa ttgtgatttt ataaaaaaga cacctgagca 3077521 aatcaggtgt cttttcatta tgcttgtttt tctttctgga acttgttact cacaaatgga 3077581 taaacgatta agccgacaaa gaataaaccg atgccgagta taaatgtcgt taaatctgct 3077641 gtgcctgtta cgataacaaa cacggagtat gcacacgcca gtatcgcgat caatccgtct 3077701 cttacacggg agcctttcag ctggtcatac gtttcacctt tgatgactac cttcaagctg 3077761 tagattgcag ataccagata cggaattaaa tatgcgagtg tagccgctgt cgttaaaaat 3077821 gtaaatgcgt cacttattgt ccgggaaata accgagaaaa tgaagacctg tgacatgacg 3077881 tttgtaataa tgagtgcaat gaccggactt ccctttttat tcgtttttgc aaaaaatgcc 3077941 gggaaatctc ctgctttagc ggcttggtat ggcacctcag agccaagcaa aatccagccg 3078001 agcatcgttc cgaataaaca aaggatagcc aaaagcgcca taatcacgct tcccgcgttt 3078061 ccaacaatcg catagagtac atcaacaaat ggtttttcag agccgacaag cttatcatgc 3078121 ggcagaacac ccatcgtaat taaagtcaca ataatatata tgctcaaggc aatcagcaag 3078181 ccggtaattg tcgcacgttt cacatcacgc tgagagcgcg cacggccgga caggatcacc 3078241 gcggattcaa ttccgacaaa cgcccacagt gtagaaatcg cagcgttatg aacctggcca 3078301 ccaattccaa tgcttgtgcc gttttctcct tgaaccggga aataaaaatg accgaataat 3078361 gacgtttgaa acacaaacaa accggcaacg ataaagaaga caaaacctaa tactttagaa 3078421 agcgttgtga caaagtttaa tttacttgcg ccgttaatgc tggcaacaag aatcgcgtgc 3078481 gttccccata acaagatcgt acatacggca aacgtcagta attggccgag tgtcacctct 3078541 tgcccgccga tcgaaaacat ctcacgttta tcaaccaaga tcgggaagaa cgaagtcaag 3078601 taaccggcga gacttgtgat gatcgccacg ttactgatcc agctcgccac ccagtagccc 3078661 cacaccattg tgaaaccggc agcgttgcct tttttcgggt cagaaaacag cgctcttgca 3078721 taactttgcg gtcccgctgt cagttcaggc ttgcgaatgg acaagtgtcc gaacacaagt 3078781 gcaatcatca gcacgccggc acctgtcaaa agccaggcgg acgtagctcc aaacggactc 3078841 gcaattgaag caagcgagct cggcaaggag aaaattcctg atccaaccat atttccaacg 3078901 acaaacgccg ttaataacca aaaaccccat ttttttgtct gttccattcc agtacctcca 3078961 tgattctttg tacggaccag accccgagat catataaacg caaaaaaagc ctgaacaaaa 3079021 gtccatgctt aaagaaacac acacccttga tctccggata gccctccgcg aaaaagcacg 3079081 cggcagtcct gcacttattc agatacagtc ccagcataga gaaggatcgg ctttctccac 3079141 acttcggcgc tgatgccttt tacacatgtt taacagcccc tgtcagccta gcatgtgtga 3079201 ctcatcatcc gcgcaacctc tacctcactg agaaagagtg aggatttaat tattcagtta 3079261 ctcccagaag gttatcaaag aaaggatgat ctgtcaaagg gaacagatgg aaaatacgga 3079321 tagagccaag ccctatccgc atgtggttat cgattatttt tctttttttg cacagcttct 3079381 tgaagcggat catcttttag agctgaacca gcatcttcaa gagctccttg gattacgttt 3079441 ttttcttttt cggaacgttt tcctttatct ttattaaaga aacccattcg tatcacctct 3079501 tttaaaaaat aggtacatgt ttaagatgcc tttttcctga aaaattatgc gggatatttt 3079561 ttatcgtcca aagtcctgtt gatcaaacat acattctctt gatatatttg taattcagag 3079621 attttttgca aaagataaaa ggagaagcgg caaatgacag gaaaaacaca catcatggga 3079681 ggcatcgctt cttgtacggc agcggcttat tattatggat ttgatccagt gcttatggct 3079741 gcgtcaggcg cggttggagc attaataccc gatatctgcc acacacaaag caaaatcggg 3079801 agaaaatttc ctattttatc gaaagtggtc agctccgttt ttggccatcg cacctttaca 3079861 cacagcctgc tgtttatgct catcatgttt tttatcactt ctacatacat tccagataaa 3079921 aacatatcag ccggcctgat gatcggaatg gcgagccact tgattcttga cgcttggacg 3079981 gtgaacggaa tcaaattatt attcccttcc acgatccgcg ttcggcttcc attatatatg 3080041 aagacaggca gtttttctga gcagctcgtg ctagccggcc tgacccttgc ttcatgttac 3080101 tacttttata tgctgtttca tggccgcatg ttttaaacat gagtgctgag acttgtctga 3080161 accggctgtt tttagtaggt tttacttaag aagcatttca tgcagatgat caagaaaacg 3080221 tgaggagtca tattgatgaa aggaaccttt tttcacaatc agcggttttt atgtttttcg 3080281 atcttattta tgtggatcaa aacgtatgtg atatataaac tcggctttga tttgcaaatc 3080341 gatactctgt tggaggagct aatgctgctg gtcaacccgc tcagctttat tcttccttta 3080401 ttcgggatcg gcctgtttct aaaagaaaac aagcagcggg cctttttgct gattgccaat 3080461 ttggttctga ctgttatctt gatctctaat acgatttttt acggctttta tatcgatttt 3080521 attaccatcc cggttttatt tcaggccagc aacatgagcg atatgggcag cagtgtaaaa 3080581 gaactgttcc atcctctgtt tatcgccctg tttgtggatt tggtttttct gctgttgttc 3080641 gccagaaaaa ccaaacaccc acagacaaaa gccgctcccc acacgatcaa acggtactat 3080701 gcagcttcct gcggaatgct tttatgcaca ctggcacttg cagaagtaca gcagccgaag 3080761 cttttggcac attcttttga ccgggaaatg ctagtcaaaa gcatcggcct gtttcagttc 3080821 catatttacg atacaatttc tcagactgtt aatatcagcg cgaaagcttt tgccgatgaa 3080881 gacagtataa ctgccattaa aaactacaca gaggctgatt acagcaagcc tgatcaaagc 3080941 aaattcggtc ttgcaaaggg gcgcaatgtc atctttgtaa cacttgagtc gacccaaagc 3081001 tttgttctga atgaaaaagt aaatggaaaa gaaattaccc catttatgaa tgatctcata 3081061 aaaaaaagct attcctttga tcatttctat cagcaaacag aacaaggcaa aacatcagat 3081121 tcagaattta tcgtcgctaa ctcactgtat ccctccctta gcggcgccgt ctttttcacg 3081181 aaaagcgacc atcaatttca tacgatgtat aaatcgctga agcagcacga ttattattca 3081241 gccgtctttc acgctaacca taaaacattt tggaacagag atgtcatgta cgatacattt 3081301 ggcattgacc gcttttttga tgttgatgat tttcatgtca ctcccgggac atcgacaagc 3081361 tggggcttaa aagacaaaga atttttagag cagtccgcca aaaagctgaa aagcctaccg 3081421 cagccgttct acagcagttt tatcacgtta acgaatcatt ttccgtttga gattgatgaa 3081481 aaggatcagc tgatagatga attcgattca agcagtgatc tgttaaaccg ctatgtgacc 3081541 acggttcgct atgaggatga agcattgaag cattttatca aaaaactgaa ggacgaaggc 3081601 ttatacgaaa attcgatgat cgtatttatg ggagatcatt acggcatttc tgaagcccat 3081661 aacgaggcaa tggctgagtt tttagggaaa gacgaaatca caccgtatga caacgttcag 3081721 ctccagcggg tgccgtttat catacatatc ccgggaatca ccgatcaaca gccggaaacc 3081781 atccctgatg ccgggggaca ggtcgacgtc aggccgacgc tgatgcattt gctcggcgtt 3081841 gagacaaaag gcgatatcca attcggcaat gatttgctgt cgggcgaccg caccccattc 3081901 gccgttctgc gaaacggcag ctttattacg aacgattatg tatacacaaa gaacacgtgc 3081961 tatagccaaa aaacaggtga agtgctggaa gatcaggatg cgtgcctccc ttacaaggag 3082021 aaagcaaacg aagaactgtc tctctctgat aaaattttaa atggtgacct gctcaggttt 3082081 tccgaatgaa aaaatccctc tatcaagagg gattttttac gtttccaata tcaccttgcc 3082141 agtcagcttc gtttcatagc cgtttaaatg agacagattc gccttgtagt cctcagaatt 3082201 caaaatctcc ttcacggctt tgagcaactg ctcatttttt ttcaaaacaa cgatatcata 3082261 ttgttcgtcg atgagcggga taaaatcaac actgcccata tgtgccgcgt gctgtgcccc 3082321 gattcccgcg tcagcctgtc cgcttgaaac ttgtgaagcg gcagcgtaat gatcagtcac 3082381 gatatcgcca tatcccacta catcagccgg attcacacca agcaagccaa gctgttcatc 3082441 aaggagcacc cttgcgccag aacccttttc cctgttgatg atccggatat cggctctttt 3082501 caagtctttc cagccttgaa tgtttttcgg attccctttt tgcacataca gtcctgcttt 3082561 gcggagaacg acattgatga gacaaaacgg ttcacctgtc aaaatccgtt ttacataagg 3082621 cgcgttatac tggcccgttt ctgcatcgta caaatggagg ctgacaatgt cacacttgcc 3082681 ttgatacata tcaatcaggc tgtttaagct tcctttgtat ttacggagcg gcgtctcctg 3082741 aatggcattc tccaaatgct tgctgaggat atccatcgaa atgtcctgtc cgctgatcat 3082801 gacatttggt ctgccgtccg gctcagcctc ctgcacctgt ttcggcgctt cttttgcagc 3082861 gatgggctga gacattctca tattcgtttt atattgcttt aaatcttctt catccacacg 3082921 catctgcctt ccgacacggt aagcaggcag cacgcctttt ttaatcaagt cataaacggt 3082981 cagctttgat accttcagca gacctgcaac ttcttctatc gtataggaag aggtttcatt 3083041 catcatcatc actctcctat tttattatac cttttcgccg aatgtaaaaa aacccacata 3083101 aaccaaacat aatcagttat aattagttat atctaatgat aaggggtgca atcatgttta 3083161 agaagtattc tattttcatc gcagccttaa ctgcttttct gcttgtagca ggctgttctt 3083221 caaaccagtc ttcaacggac agcgagaaaa aagtaacgtt aaccatctca gctgccgcca 3083281 gcgcgcagga tgcacttgag gaaatccaaa aaaattatga aaaagatcat caacatataa 3083341 ccatccaaga taactatggc tcatccggcg ccttgcaaaa acagatttct caaggagcag 3083401 gagcagatct gttcttctca gctgctgagg ataaatttaa aaagctggtg gatgatggag 3083461 atatcgcaaa aaaagacagc actgaattag tcggtaatga aattgtgctg gtcgtaccga 3083521 aaaacggaga ttcacctgtg acaagcttca gcaatctggc tgaatcagaa aaaatcgctc 3083581 ttggcactcc ggaatccgta ccggcaggag cttatgggaa agaatcactg acaaagctgt 3083641 ctttatggga caaagtgaag gataaaattg tgtatggaaa agacgttcgc caagttcttt 3083701 cttatgttga aaccggcaat gtagacgcag gtgttgttta taaaacagat gccctagtct 3083761 cgaaaaaggt caacattgtt gacgaggcaa aagcagatac acacagccca attgtctatc 3083821 cgttaggaat cgtaaaagat acaaaacacc gtaaggaagc gaaggaattt tacgaatacc 3083881 tgcaatctga tgaagcaatg aaagtatttg agaaatatgg ctttactgcc gagtagcata 3083941 agcgcttcag aatttttcac acccgttgtg ctttcctttc aggtggcggc agttgccgga 3084001 attgttgtca ttattctcgg aacacttgct ggagcatgga tgtcacgggc atcatttttc 3084061 ggaaaaacgg cactcgaaac atgttttatg cttccgctcg ttcttccgcc tactgttgtc 3084121 ggttttattc tgatcgtcat tttcggaaag cacagcttca tcggacaagc catcgagtgg 3084181 attttccagc agcctgtcat tttcacctgg tgggccgctg tgatcgcctc ggctgttgta 3084241 gcctttccgc ttatgtatca atcagccaaa accggatttg ctgacattga tcccgatata 3084301 caaggtgcgg caatggtaga cggcgctagc agatggaaag tgtttatcca tatctccgtc 3084361 ccgcttgcct atccttcgtt actgaccgga agcatcctta gccttgcgcg ggcgctcgga 3084421 gaatttggcg caacactcat gtttgcagga aacatccccg gtgttacgca aacactgccg 3084481 acggcgatat atgtcgcatt ggattccggc aacaataccc ttgcttgggc gtgggtcgtc 3084541 tgtattgttg tcatttcctt tttgatgctg tttttcattc aacagaaaaa aacgcactaa 3084601 aaaaactccc cataacgggg agttttttga ttaaaacaga agctcatcag gatttggacc 3084661 gacacgctca tctttattta atgcgtcaat tttgtccatg tcttcttgag acaattcgaa 3084721 atcaaaaata tcagcgtttt cgatgatacg gtgttcttta atggattttg gaatggttac 3084781 aactccatgc tgcagatccc agcgcaaaat cacttgagcc acagatttat tgtgtttttc 3084841 agcaatctgt gtcagtactt cgttatccaa aagctgtccc tgcatgagcg gagaccacgc 3084901 ttccagctga atgccttgcc ctttgcagta atctcttaat tctttttgcg tcaagcgagg 3084961 gtgaaattca acttggttca ccatcggttt gatttcagca tctttcaaca gctcttctaa 3085021 atgatgaact tggaaattgc tgacgccgat cgcgcgaatt ttgccgtctt tgtacagctt 3085081 ttcaagcgcg cgccatgtat ctttatattt atctttgcca ggccaatgga tcaaatataa 3085141 atctaagtaa tcaagctgca gtctttctag gcttttttca aaggcagcaa gcgttgtttc 3085201 atagccttga tcttcattcc acacttttga tgtgatgaag agctcttctc ttgccacacc 3085261 ggattcttta atcccgatgc caacgccttc ttcatttttg tagatcgctg ctgtatcaat 3085321 actgcgatag ccatttttaa ttgccgcttt cactgattca gtcgcttcat taccattttc 3085381 tactttaaaa acgcccagac cgaaccaagg catttcaact ccgttatgta actttacagt 3085441 atcttttaaa cttgttggca cttgaacctc caccctttca ctgaaatgta agcgtctata 3085501 ttatctcaca ttcctctcag ccgataccaa taatacgctt aagaccctct ttttgcttct 3085561 tttttcacag cacaggcaaa tccaaacact atttttttcc tattttaaca atattgagat 3085621 tacaaataca ttgagcaggg tatgcgtgta gtgtaaccaa atgaaaacaa aggaggaaac 3085681 aacttgaaac gtattcgtat cccaatgaca cttgctcttg gtgccgcttt gacaattgcc 3085741 cctttgtcct ttgcttccgc tgaagaaaat cctgctccga agatgtcgca gacaactact 3085801 gctggaacaa ctgccgctga tgtaggttta aacgtcaacc tggatgtact tggaattgcc 3085861 aaccagatcg ctgatgccat caaatccgca cagaataggg atggctttgt gaaaaacctc 3085921 atggagtctt ccttctacgc gtccggccaa aaatataacg tcatggtctt taatttaagc 3085981 caggaatatg aagatcattt gaacggtgtg caattttacg gctcagccgt ttacgacggc 3086041 attacgtatg gcatttgggt atttgaagat ggaaccttta caaacaaagg cgatggcggc 3086101 tggatcaact gggccttcag aggctggttc gaccgggatg gcagcactgt cgcatttcat 3086161 cgcccttaat ataaaaaaag ctggcgctct aacgccagct ttttttctgc atttattcgc 3086221 cgccttcaag catggcggct tcgacatcat taatgtattg gcgaagctca tgggagatgt 3086281 cccgggaaat ttccctctct tcgaagagcg tttgaatttc atttctgatc gcctgcacag 3086341 ccttcagctt cacttccagc ttctgatttt caaaatgggc acttgatttt aactcatgat 3086401 ggctgtgctc cagcctgaaa attaactgct tatagaatgt aatgacagat aaaaacactt 3086461 ctttatgctc atccgtctta tgtttttcca gatattctat cgctgctttt gccgttttca 3086521 ctcttgttgc ccgtatcaat cccgcttcat ttaaaatcga catctccggc tttttatgtt 3086581 caccgaagaa aatccaatac atcagcctct tgagccttgt ttttgataac ccgactttaa 3086641 acgggttggc atacaaaatt tccaactcgt taaatcgttc ttgcagcaca tttgctgttt 3086701 cttccgggat gtctccccgc tccagcattt tcatcagcgc ctcttgctca gccttaaccc 3086761 cctgcgcacg gacttttcgc tcgtgcttct taatgcgatt agatgatgta tactgctgaa 3086821 aacgaagatt tttcattttc tcattgtatt cagctatcac cgcaagagag gccgttttgt 3086881 ttgtctcatt catgtcctct ttaatcgttt gaagggctgt tttgatcaac ttgcgtctcg 3086941 ccgtcagcag cttcttattt cgttcctcgt cctcttcttc tttttcagtc agaattggca 3087001 gcacaacggt ggcaatgaca agcgtgcata aaatgacgcc ggctgctaaa aagagaatca 3087061 gatttctttc cggaaacggc gtaccgtcct ccaggaaata cggaatggaa aaagaacctg 3087121 caagcgttac tgctccacgc acaccggaaa tcgaaattaa cagcgtcgaa cgaagacccg 3087181 gtttatagat gttctgatct ttattaaaga accatttgcc gttccagaag aacagcaccc 3087241 acaggaatct aaggagcatt aatgtaaatg tgatgactag gatatagccg atcaccttca 3087301 tgttgctgat ggcagtgtcg ttaaagataa cagaaataac atcagggatt tgcgtgccga 3087361 gaataacgaa gaccaggccg ttcaaaataa ataaaataat gttccacgta cttgaggaga 3087421 cgatttgcag cttgatcatc gttgattcca gacgatcctg ttcaaccgca tgggtaatac 3087481 cgccagctac aacagctaaa atgcccgaaa cgccgatttc ttcagctgcc aaataaatca 3087541 caaacggcgt cagaatttga atcagcatat gcatcgtgac atcctgcatg ccaaggcggc 3087601 gcagaaatag gcgaaaacga ataatcaaaa atgaaatgac aaccccgcac agcaagcctc 3087661 cgagagaaat aaagacaaag ctgacagccg cttgtgctaa tgaaaatgca ccagtcactg 3087721 ccgctgcaat cgcaaactta aaggccacca gacctgatgc atcattcatc agcccctcac 3087781 cttccagcag gcgaagaatc ccttttggca ttttcactct tcctgataat gcgctgacag 3087841 cgacgacatc agtcggtgaa agaatggccg caagtccaaa ggccgctgcc agcggaatag 3087901 caggaatcat ccagtgaatc gtgtagccgc ctacaatcac agtcgcaaat acaaggccga 3087961 gtgcaagcaa taaaatcgga gcccttaaat tccaaagctc tgcccgcggt gtcctctttc 3088021 catcattaaa tagcagaggc gcgataaaaa gaacaaaaaa caattcggtg tttaattcaa 3088081 aatgaagtcc ctgtggaaat gaggcggcaa gaatcccaag agccacttga atcagcggca 3088141 ccggaataaa cggaataaac cggttcacga tattagaaat cgcaataatc gttaataata 3088201 cgagcacaac taaaaatatg tccaaatgca tgacctcctt cgtctgttgt gtgtcggcat 3088261 gatgagccaa aaaatctgtt tgtctaaaag cccttgagct agggtggcct tgcatccgct 3088321 atgtggtttc gcaggagttc tctccacact tgtcttcttt tatagtaccc tttttagggt 3088381 attttttctc atgatatgct cacagtgaac ttttttgcag aagagcaaat tatagaaaaa 3088441 agagacagga agctactccc tgtctctcgt ctttctttct caatcatgaa aattcgtacc 3088501 gtcagttgtt gctttaataa tgcccgcgcg aatgacaaag tcaccgaaat gctcgccttc 3088561 ctcgcgttct ttcgcatagc gggaaagaag gatgcgcagc tcgcttaaaa tgtctgcttc 3088621 accgatgttt tcacggtaca ttttgcttaa acggcttccg tcaaacgcag cgccaagata 3088681 catattatat ttgcccggcg cctttccgat aaatccgatc tcaccgagtg catgacgtgc 3088741 acagccgttc gggcatcctg tcatgcgaat ggtgatttcc tgatcacgaa ggccgttttc 3088801 gtcaataatc tcttcaatct tatctaacag ggtcggcaaa taacgttctg cttcagccat 3088861 tgccaatccg caggtcggaa gagcgacgca cgccatcgag ctgcggcgaa gcgctgaata 3088921 gtgcttgccg tcagttagtc cgtactgttc aattaaagca ctgatttctt cttttttatc 3088981 gcttgaaacg ttcgcaatca ttaagttctg attggctgtc agccggaact cacctgtatg 3089041 aactttggcg atttcccgca agccagtcat cagcttataa tcatcgtaat ccgttatacg 3089101 gccgccttcg acaaacagcg tgaaatgcca tttatcctcg atgccttcca cccagccata 3089161 gcggtcgccg ttatgatcga aatgatacgg cttcgcttct tccaggctcc agccgagacg 3089221 gttttccaat tcttctttta cgttttctaa accgaggcgg tcaactgtgt atttgaaccg 3089281 cgcattttta cggacagaac ggttgccgta atcacgctga atcgtaatcg ttttttcagc 3089341 aacgtcatac atttgctcag gccggcagaa accgatcacc ttggctaatt gcggatatgt 3089401 cgcagtatcg ccatgcgtca ttcccatacc gccgccgatt gccacgttaa aaccgatcag 3089461 cttgccatcc tcgacaatcg caatgaatcc gagatcttgt gaaaagacgt caatatcatt 3089521 agacggcgga acggcaatac cgattttaaa cttccgcggc agatagagcg gtccgtacat 3089581 tggctcgact tcttcctccg gcgtgccggc aactctttcc tcatcaagcc aaatttcatg 3089641 atatgctctc gtccgcggca gcagatcatc acttaatttt ttagaccact cgtatacctc 3089701 tgagtggatt tcagattgat aagggtttga tgcacacatg acgttacggt ttacgtctcc 3089761 gcaggctgcg atcgtatcca aaagtgctga gtggatcgtc tgaatggttt tcttcatgtt 3089821 ccatttcaga attccgtgca tttggaatgt ttcacgtgtc gtcaatttta atgtgccgtt 3089881 cccgtatttc tgggacaggt catccatgac aagccattgt tcaggcgtcg agacgccccc 3089941 tggcatacgc acgcgcagca tgaactgata tgcgggctca agcttctgct tttggcgttc 3090001 atttcggagg tcgcggtcat cctgcaaata actgccgtgg tgtttcatca ggcggttatc 3090061 atcatccgga attcccgcac tgattcgatc gagcatcact tctttcagcg tgccgcgcaa 3090121 ataatcactt tcttttttaa tgcgttcaac atcacttgga gagccgtccg gtgcttttag 3090181 aattttggtc accatgttga aaaactcctt tcaagtcaaa tcaatataca tcacgctgat 3090241 agcgtttttg ctgctgcata tcggcaagat aagcctccgc ctcttcgcgg ctcatattgc 3090301 cttctttttc gataatttca agcaatgtgt tatggacgtc atgcgccatg tgcttttcat 3090361 ctccgcaaat gtaaacagcc gctccttctt gaagccattc aaacaattct gcgctatgtt 3090421 caagcatgcg gtgctgcaca tatacttttt cttccgtatc acgtgagaac gccacatcca 3090481 tttttgtcag cacaccgtct ttgagccaat tctgccactc tgtctggtaa aggaaatccg 3090541 tgacaaagtg ctgatcgcca aagaacatcc atgcctttcc ttccgctccc gtctcctcac 3090601 gctcctgcat aaacgaacgg aaaggtgcga cgcctgtccc agggcccacc atgataatcg 3090661 gtgtttcagg gtctttcgga agcttaaagt tttgattgtg ctgtacataa accggcagtg 3090721 tgtctcccgg ctgcagtcgt tccgcgcaca aaatcgagca gacgcctttt cgttcacggc 3090781 cgtgcgcatc gtagcggact gcgccgattg ttaagtgcac ttcatccgga tttgcggata 3090841 aactgcttgc aatcgaataa aggcgggcag gcatttttcg caaaatcgag acaaactcct 3090901 gcgcagatac actaaatggg ccatagtcac ggacgagatc aagcaaatcg cgcccttcaa 3090961 tataggcttt tacattctcc tcatttcccg gggctaaaag ctctctaagc tcatcgttcc 3091021 ctgtcagctg ggctgcctgt tcaagaagcg gttttgtgag aacggtaatc tcatagtgag 3091081 aaatcagcgc ttctttcagc ggtcggacat caccttgctt attaagcgtc acaatttctt 3091141 ccgggtccca attcatttcc ttaaggagca gctcgacaag ttccggatcg ttttccggat 3091201 agacgccgag gctgtcacca ggctcgtaag tcaggccaga tccttcaaga gacagctcca 3091261 catggcgtgt ttctttattt gatcctctgc cgtttaaatt taaattttct aacacttcag 3091321 cccgaaacgg gtttgttctg gaatacgaag actcaccggt ttgtgacgca gccgccggcg 3091381 caggcgcggc gcttccgccc ccagcttcat ttaatccttt caatacaccc tcaagccatt 3091441 cggctgccgg ttcatcatag tcaagatcgc aatcaacgcg cggagaaatc cgttttccgc 3091501 cgagttcttc taagcgttga tcaaattctt tccctgtctg gcagaaaaat tcgtacgaac 3091561 tgtcaccaag cgccaaaacg gaaaagcgca ggtcttcaag cttaggcgcc cgtcttccgt 3091621 gcagaaattc atgaaacgac agcgcgttat caggcggctc gccttctcca tgcgtactga 3091681 cgacgattaa aagattggtt accttcttca gctgattcgg cttaaaatcg ctcatggatg 3091741 agacggtcac ttgaaaaccg ctctgttcaa gctgcttgcc ggcattttct gcaagcccct 3091801 gtgcgtttcc cgtctgtgaa ccataaagaa cggtcacttc ttttgaaacg gccggtgccg 3091861 gtgcttccgc tgacacagct gccgccggcg tacccgcagc ttcttgggcg gaaacagatt 3091921 gagcggataa atatccgctc agccagattt tctgggattc ggtcaaggtc ggcagaaggc 3091981 ggttaaggag ctctgcctgc tcctgattaa acggactgtt cattacctga agttgcaacg 3092041 tatccacctc acaaagttat aaactgatcg aaaattgcat ctaattgaac tttaccggaa 3092101 tactaggctt aagtaaaata tatttacatg atgataacta ttaagaatcc taatgataaa 3092161 acggctatgc ttcatgtaaa tagaaaaaag agaaggactc ccttctcttc attcagcaat 3092221 ctgatataag tgaggcggca cagcggttac aaacggactg gcttcacctg tataaaatac 3092281 cgccagcatg tgcatcgcac gggtgcacgc agtatataaa agcctgcggt cgtgctctgt 3092341 atgatagtgt tcttcagatg catcatagac aagcactgcg tcaaattcaa ttcccttcgc 3092401 taaatacacc ggaatcacgc aaacaccctt ttgaaatggt tgattttctt tatgaatcag 3092461 gcgaacatct gtatattcac tcatgtgggc gtgcgcctgt atgcattgat gcgcagtctt 3092521 gcagatgacg gctattgttt cgtgcccttt tttcttgagc cggccaattt cttgcgcgag 3092581 cttttggcaa aggctctcat gtccttcagt tttgacaacg agcggcattt ccccgcttct 3092641 attaaacggc tcaatatccg ctccatcttg aagcatcgct ttggtaaact cgacaatctg 3092701 ccttgttgat ctgtatgttc tctttaaacg aacatactca gcaggctcat cctcaaagca 3092761 cgcatccata cgctgatccc cgtttatggt atgcgcgtag atggactgat tgatatcacc 3092821 gagcactgtc atgctggcag ccggaaaaat gcttctcatg taagccatct gaaacggtga 3092881 atagtcctgg gcttcgtcaa taaatagatg tttgattttc gtatttttct ttctgccctc 3092941 aatcagatcc tgcatataaa gaaacggtgc cgcgtcctca tagagcaatt tattatccgt 3093001 aaatgccgaa cgggtcagct cacctatcgc atccatcttc tcatgttgaa attttcctcc 3093061 ccagccagaa aacaattgca aataaagttg tgtaacatca agaaatgcaa ggagcctgac 3093121 tgcctgtttg agcggtttga aagctttttt cacaatgatg gcggcaagca gctgctgctc 3093181 tctttgataa tcgttaaacg tactctcgct gaaccgtttc ctttcctgca gttttttgta 3093241 cacgtccaag tagtcctctt tgtcaagcag ctcagcttca tgaacaaccc aatcctttcg 3093301 ccgttccttt ttctcaagct tgttaagctc actcagcagc cacttcgcgg tttgctccat 3093361 ccgattcgga atggagtgat tttgatccaa tgagtaaaaa taggattgaa tttgctcctt 3093421 tgtgatcagc ttttgtccgc ggaatataat atttttaaaa atcatccctt cagaggaaag 3093481 ccgtgtgacg tattcattaa tgaattgctg aaaggataaa cccgccttcc atgtgattcc 3093541 tgcaagcctt gttggaaaat cgcctccctt tgtttcggtc aggcaatatt cgagctgatc 3093601 aaaggggctt tcacatttga acttgcggcc aagacgatgc tcgatatatt cctgaaacgt 3093661 cgcctgctcc atattctctt ctcctaactc cggcaaaaca gaggagacat agctgttaaa 3093721 taagaagttg ggtgaaaaca aaacgatttg tccggcatca atgacaccgc ggtgcctgta 3093781 taacaaataa gcgacacgct gaagcgcagc cgatgttttc ccgctgccag ccgctccctg 3093841 cacgatcagg atcttgcttt tttcattacg gataatctga ttttgttctt tctgaatcgt 3093901 agacacgatg tttttcattt gggtatcaga gtgatggctt aatacctctt gcagcatttc 3093961 atcgccaatc gtcatatcgg tattaaacat cgccttgaga gtgccgtttt tgatcataaa 3094021 ctggcgtttc agcaccattt ccccttctat cgtttcaccg ggcacctcgt actccgcttt 3094081 tcctggggaa taattgtagt acaaacttga tatcggcgcc ctccagtcat agatcagaaa 3094141 gtgttcctcc ttctcatcca aacaggaagc taaaccgata taaattcgct ctgcctgctc 3094201 ctcgccgttt tcaataaaat caatccggcc gaaataaggc gattttttca attgatgaat 3094261 tcgtttgagc tgctgatcca tgcgccgatg attgtgttcc cgatcagaca gcagctctgc 3094321 ctgctgctta atgctagcca tcgtttcaat cgcttcatgg gcatcatcaa aattaacctt 3094381 aacatcctcc caaaagcttt ttcttaatcc gatgatatca tgcttcaacc cgcccgcaga 3094441 cgtttccaga aaccgctctt ttttttcgag ctccttcagc acctcatcta ttctcgactg 3094501 ctcttccttc cattccttat cctgctgatt catgaacggc acctccagaa aatagttgac 3094561 aaacatagat gaaatactgt aaaatataat tggatacata tattaaatat atgatgcaaa 3094621 ctggcaaata caatttataa tagcacattc acccaatacc aatcaaggtt tgggttattt 3094681 atattatgca gaaaaaaacc gatttcactt cgaaatcggt ttttttgcta ttaattatct 3094741 aagcgaaaag aacggtttgg cagcttccaa ttaaacatat aggaacaaac ccggcaaaca 3094801 acgagcacga aaaacagaac gtataagccg aacgagttcc ccagccagcc caagccgacg 3094861 attaaaccgc cgagcgccgc ccataccgca tagatttccg ctttcagcac aagcggtttg 3094921 cgcccggcaa gaaggtcgcg gatgatcccg cccccgcttc ccgtcagcac cgcagccacg 3094981 atcacggcac taagcggatg gcccattttg acggcataca gtgcgccttg gatagcaaag 3095041 gcagcgaggc cgatcgcatc tgataaattg ccccacttat tccaatgctt cagcagcagc 3095101 ttcggaaaca gaaacacaat tgtaatagat aaaagcgcga tttgaaagta cgctccctgc 3095161 tcccatagcg ctgacaccgg aacaccgatc agcaaattgc ggatcgctcc tcctccaaaa 3095221 gctgtgacaa tccctaatat ataaactcct aaaatatcat attcctcttc catcgcaaca 3095281 attgcgccgc tgactgcaaa cgcaatgatg ccaatcacac taagcagctc ccaagccatt 3095341 ctgatgactc ccttttatgt ttgttaaatt ttctgacgac ctctagattt tataatcgct 3095401 ccagcgtaaa atcaataaca ttttcatgag aaaaaaagat aaatttagag ggaatacggc 3095461 tattgctgat ggacatgagt ttgcgaaatt aaaaaagcgc ccggcatacg cgggcgcttt 3095521 ttttgttatt cagatttttc gcctttcagc aggcacataa aaatgataat caggataaaa 3095581 gcaatcaggg ccaggaatgg aatcgtaata aaaccaaacc agttaatata ttggcccgag 3095641 cacggcacgc cgctgacaca tggcttaatg ccgctaaagc cgggcacttt ttgctctaag 3095701 taatgcatga tcgaaatgaa tgccccaata atcgccatcg ggagcacata ttttttcact 3095761 cgtgtgtccc cttgaaaggt ggcgatgcct aaaatcagga cgagcggata catgaggata 3095821 cgctggtacc agcacagttc acatggaata aactttctga tttcactgaa atacaggctg 3095881 cccagcatag cgataagagc cacaacccag gaagcatata aaaatacgat tctatttttc 3095941 atattgttac ttccctttca gctctttttc tattgtctct ttgatttcat cataatccgc 3096001 aaaatttttg atcactttat cattgacgta aatcgtcggt gttgcctgta tgttcatttt 3096061 ttgattaagg tcagaatcct tttccacttg agaagcgaat gtttccttat caagattttc 3096121 cttgagcgtc tcaggtttta tctttgtggt gctttttgca agatcaccaa ggaggcctgg 3096181 ggttacccat tcctgttccg tatccggctg tttttcgaac agcttttcat ggaaatccca 3096241 gaaagagtca gggtcttcct tccatacttc ttcagatgca agagccgcta accttgaacc 3096301 ttttccatgg aacatgacgt tcacgaaaga aaatttcaca tcgcccttat caataaagtc 3096361 tttttgtatt tttggaaaga tgtcactgtt aaacaccttg caagacggac atttgtaatc 3096421 tccgaattct actacagtta ccggtgcatc gtccttgcca agcacaggct gccctttgat 3096481 agacggctgt ccggacaccg catcattgcc ttgttccgtt ttgttattaa tgatgacaat 3096541 ggctgctagc aatacaacaa ccacaaccgt aaggatgacc gcgaatttcg cagaagactg 3096601 ctgtttcttt ttcactccga cacctcatcg ttttaaaatt aaaaaagaag cggatcgcaa 3096661 ttgacccact tctttatttt aacaagacaa gcgctgataa gaaaaccccg aaaaaatgaa 3096721 ttctctccga caatttattt gtttttgaga cgcatgacgc gcatggcgtt cgccacagca 3096781 agcagtgtaa cgccgacatc tgagaaaacc gcttcccaca tggtcgcaat tccaaatgca 3096841 ccaagaatga gaaagatcgc tttcacacct aaagcaaagc cgatgttttg ccacacgatt 3096901 cgccgtgtcc gtttcgcaat ccgaatcgct tctgctattt ttgacggctg atctgtcatc 3096961 agcacgatgt ctgcggcttc taccgcggcg tctgagccaa ggcctcccat cgcaacccct 3097021 atatctgcgc gtgcaagcac cggcgtatca ttgatgccgt caccgacaaa aatgagtttt 3097081 tcactaggca aaagcttagc ttctaatgct tcgacctgcg cgactttatc ttgcggcagc 3097141 agctctgcat atacctcacc aatcccaagc tgttttccga cggcttctcc cgtttgtttc 3097201 gaatcacccg tcagcatagc tgtctgtttg atcccaagcg acttcagatc agcaaccgcc 3097261 tgtgctgcgt cttcctttat ctcatccgct atgatgattg ctccggcata gcgttgatct 3097321 acagcaacgt gtacgattgt tccagcattt tcatccggga catcctcaat ttgttctctt 3097381 tccatgagct ttttattccc agcaaggatc tcagttccat ttacctttgc aaaaatgccg 3097441 tgaccggaga tttcttcgta tgactcaatc tcatcggagg aaagcatttt cccgtaagct 3097501 ttacgcacag attcagcaat cggatgctgt gaatgaagct cagcgtatgc cgccgcttca 3097561 agtaatctat cctttgtaaa accttccgcg ggtttgattt ctgtcacttc aaagctgcct 3097621 tttgttagtg ttcccgtttt atcaaacacc gcgtatttga cttgattcaa agcttctaaa 3097681 taattgcttc cctttacaag cactccggcc tttgaggccg ctccgattcc accgaagaaa 3097741 ccgagcggaa tagagacaac aagcgcacaa ggacaagaaa tcactaaaaa gataagcgcg 3097801 cggtacaccc aatcggaaag cgcggcgcca gaaagaacaa gcggcggaac aaaggccagc 3097861 aataccgcaa tgatcaccac agcaggtgta taatacttgg caaacttcgt gataaagttt 3097921 tctgtccggg ctttacggct gctcgcattc tgaaccaagt ctaatatttt tgatactgct 3097981 gattcctgat agccctttgt gacttcaata tgcagaacgc cgttttgatt gataaagcct 3098041 gacattacat cttgtccttc cgcagctttt ctcggaacgg actcacctgt taaagcagat 3098101 gtatcaacca tcgctgaccc ttgcacgacc ttaccgtcca ggggtatgct ttctcccgga 3098161 ttaaccacaa tgatgtctcc tgtctgaacg tcctccgacg aaacctgttc gatgccgttc 3098221 tttgttttga gattggcgta atcaggccgt atgtccatta acgcactaat tgattttctg 3098281 gaacggctga ccgcggctcc ttgaaaaagc tcaccgattt gataaaacag cataacggcg 3098341 accccctcag ggtattgctg aatcagaaaa gcgccgattg tggcaagagc cattaagaaa 3098401 tgctcatcaa acacctgacc gcggatgatg tttttgactg cgcggattat aatgtcaccg 3098461 ccgataatca aataagcacc gaggaaaagg aaaaattcaa tggttcccga ctgaaccaaa 3098521 tatgccgctg cgccgagaat gacagccgcc gccattctga tcagcatatt gaccattcga 3098581 ttacgatagc catcatcagc tgatttcttt atatgctttt ggcgaaccgt tacatgcgga 3098641 tcaattgatt tcactttttt ctctacttta ttcgtgaccc attgctcttc tttcccatcg 3098701 gctgagacag ttaaggtgct tgccgcaaaa tttaccgcgc atccgttaat gccttttatg 3098761 cctttgactc cattttcgat ttttcgggca caattgctgc aatccaaacc gtccagaaca 3098821 tattcctgtt tcactagtct caccttacct tccgatttag ggttccctct tcaaagcgta 3098881 tcaatgagta ttgtatttat tttatatata tgagcatata ctcatatata agttacacct 3098941 attatatgtt gttttccaag aaagtgtcaa tgaaaaacaa aaaccggcat atagccggtt 3099001 tttcatttta ctttttgcag acgaagagca ttcagaacaa cggaaacgga gctgaatgcc 3099061 attgctgctc ctgctatcca cggtgctaaa aatccaagtg ctgcgattgg gatgccgagg 3099121 ctgttatagc caagcgccca gaataagttt tgtttaatgt ttttcattgt caatctgctc 3099181 atgcggattg cgtcggcaat gctgttcaga tcgccgcgaa taagtgtaat gtctgctgtt 3099241 tccatggcaa tgtccgtgcc agttccaatc gccatgccga tgtcagctgt ggcaagcgcc 3099301 ggcgcatcgt taattccgtc gcctaccatt gctgtctggc ggccttcttt ttgcaagcgg 3099361 gcgatttccg ccgccttttg ttcaggaaga acttccgcaa tgatattcgc aattcccgct 3099421 tccttcgcga tggcttctgc ggttctgcga ttgtctcctg tcatcatgat gacatcaaga 3099481 cccaactctt tcagacgggc aacagccttc cgcgacgtat ccttaatcgt atctgcaact 3099541 gctactagcc ccgctgcttc tccatcaatg gatacaagca taactgtttt cccttcggcc 3099601 tctagctctt ccatttgggc gagaagagcc ccatgctcaa cctgttcgct ctccattaat 3099661 tttcttgtgc cgacgagaat gctttttcct ccggcttcag ccaaaatgcc tgcgccgact 3099721 tttgcttcaa agcgggtaag tttcggtatc tcaagccctt tatctttcac gccagcaata 3099781 atcgcttcgc caagcggatg ctctgatccc gtttccgctg ccgctgcaaa ttgaagcaaa 3099841 tctttttctt caaaacggcc gaatggaatg gcatccgtca gacgcggctt cccgtttgtc 3099901 acggttccgg ttttatcaag aacaattgta tcgagacgat gtgttttttc taaatgctcg 3099961 ccgcctttaa ataaaatccc gaattcagca gcgcgtccag atccagccat tatgctcgtc 3100021 ggagtggcaa gaccgagggc gcaaggacag gcaatgacaa gaaccgcaat gaacttgctg 3100081 atcgcttcgg caaaatcgcc aggagccgcc caaagatacc aaatgagaaa agtgagaacc 3100141 gcaatcccca atacaatggg tacaaaaatg cctgaaatct ggtcagcgag acgctggatc 3100201 ggcgcttttg acccttgtgc ttcctcaaca attttgatga tatgagaaag cgcagtatcc 3100261 tttccgacgt tgacagcttt aattttcaga aagccgtttg cgttaacggt tgaacctgtc 3100321 acgctgtcac caggattttt gtcaacagga agactttctc ctgtaatcat cgattcgtca 3100381 accgctgaac ggccttcaac cacttctccg tcgacaggaa ttcgttcgcc aggtttgacg 3100441 taaacaatgt cattaacaag cacttcgtcg atcgggatga tttgctcctg tccgtctctt 3100501 acaacagtag ctgttttcgc ttgaagcttc atcagctttt taatcgcatc cgaggaacgg 3100561 ccttttgctt ttgtttcaaa caacttgcct aataaaatca gcgtcagcaa aatcgcgctt 3100621 gtttcataat aaaggccgtc tgtatgcccg tgagagccaa tgctttgaaa agttagataa 3100681 agactataag cgtaagcagc cgtcgtaccg agggcgacca atacatccat attggcgctt 3100741 ttatttctaa gcgccttata cgcacccaca taaaacggcc agccgatcag aaactggact 3100801 ggtgtcgcca gcgcaaactg catccacgga ttgagaaata tatccggtac ccaaatgaat 3100861 gatgtaaatg taaaatggct caccatcgcc caaagcaatg gaaatgacag gacagctgaa 3100921 aaaatcagtc tcgccgtttg cttccgttct tctttctttt tagcagcagc ctcactgtcc 3100981 tgttcaccct tcaactttag cttatatcca agcttatcta ccgcttcttt caaatcgctg 3101041 acagacgctt cttttggatt gtattcgacc gtaactgttt ctaaagcgaa gtttactggt 3101101 gcatttgcga cgccttctat tttgttaagc cgtttttcaa tccgattggc gcaagccgca 3101161 caggtcatgc cctcaatatc gaattcagct ttttctgtaa cgacgtgata gcccagcttc 3101221 tctatttttt cctgaatcgc tgcagtccct gtttcagcag gatcgtagat tacatttgat 3101281 gtttccgttg ccagattaac atttgcatcc gtgacaccgg gcatccgctt caggcctttt 3101341 tcaattctgg cagcacatgc cgcacaggtc ataccagaga cctgcatcgc gatttccttt 3101401 tgttcactca acatactcac tcctttatat acacctgggg ggtatataaa aatgaaagaa 3101461 atatcgcgcc tccctaaagg cgcgatacct tgaatcactt ggctacgtca tagccctgat 3101521 cttctatcgc atccgcaata tctttgactg atactttgtc agcatcaaac gaaacatcga 3101581 ctttacccgc ttccagattg acatgaacgg cactgacgcc gtccagttct cctacgcttg 3101641 tttctactgc tttgacgcag tgctgacaag acattccttc aacttgcaat gttttttgtt 3101701 ccatatcaat tcctcctgtt tattctttct attttcatcc taccataccc ccgtagggta 3101761 ttacaataaa aaacgcttta tgattttgtg aactttttaa atacgtccaa aagctcagaa 3101821 atggcctgtt ccccgtctcc gcttttgatg gcatctgcta cacaatgatg ggcatgatcc 3101881 tcaagcaaat gaagcgccac atttttcatt gccgcctgaa cagctgaaat ttgcacaaga 3101941 atatctacac aatatctgtc gttttccacc atgttttgaa tgcctctgac ctggccctca 3102001 atccgcttaa gccggtttgt aatctgatcc ttttctttcg agcttttatg gtttaatgtt 3102061 ttatgttcgt tatgcttttc catgcgtaca cctctgttta atgatattaa ttcccattat 3102121 actgattgtc caaacggttg tctaagcatg ccgacgcaaa aaatgaatca gttaggtttt 3102181 accatttgat caggagggta tatacttctg ttgataacgc ttttaaaggg gagaagaaaa 3102241 gtggatacga tcaaggttgg aatattagga tacggattgt ccggttctgt ttttcacggg 3102301 ccgctgctgg atgttctgga tgaatatcaa atcagcaaaa tcatgacatc acggacagaa 3102361 gaagtgaaac gggattttcc agatgctgag gttgtacatg agcttgaaga aatcacaaat 3102421 gaccctgcca ttgagcttgt cattgtcacc accccgagcg gccttcatta cgagcatact 3102481 atggcatgca tacaggccgg aaaacatgtt gtgatggaaa aaccaatgac agcaacggcc 3102541 gaagaggggg aaacattaaa aagggctgcc gatgaaaaag gcgtattatt aagcgtatat 3102601 cataaccgac gctgggataa cgatttttta acgattaaaa agctgatctc tgagggatcc 3102661 cttgaagata tcaatacata tcaagtttcc tataaccgct acagacctga agttcaagcg 3102721 cggtggcggg aaaaagaagg cactgccact ggtacgctgt atgatctcgg ctcccacatc 3102781 atagaccaaa ccctgcattt gtttgggatg cctaaagccg tgactgcaaa cgtgatggcc 3102841 cagcgggaaa atgccgaaac ggttgactat tttcatttaa ccctggatta tggcaagctt 3102901 caagccattc tatacggagg atcaatcgtt ccggcaaacg gacctcgtta tcaaatccat 3102961 ggaaaagatt ctagctttat caaatatgga attgacggac aggaagacgc actcagagcg 3103021 ggaagaaaac cagaggatga cagctggggt gcggatgttc cggagtttta cggaaagctt 3103081 acaaccattc gtggctccga caaaaaaaca gaaacgattc catcagtaaa tggctcctac 3103141 cttacttatt accgtaaaat agcggaaagc atacgagaag gtgctgcgct gccagtcact 3103201 gctgaggaag gtattaatgt catccgcatc attgaagccg cgatggaaag cagtaaagag 3103261 aaacgaacca ttatgctgga gcactaaaac aaaagcctcc ccaaataagg ggaggctttt 3103321 tcattagaat gtttttcctg cttctttcgc acgcgcaatc gcgtcttctt tgatttgctg 3103381 tgctttatca ggctccgcat tatgtccctc tacgaaaatg ccatcgaatg atggtacgcc 3103441 gaagaagttc atcatgatgc cgatgtagcg gtgccccatt tccatctcag ccgcagggcc 3103501 ttctgaatag tagccgccgc gcgcttggat atgaattgct tttttatcag ttaacaagcc 3103561 gacaggacct tgttctgtgt atttgaatga ttttcctgca acagcaacag aatcgagata 3103621 cgctttcatc actggcggga atgagaagtt ccataaagga gtaacaaata cgtacttatc 3103681 agctgatgca aattgatcgc taagctctcc caaacggcct actttcgctt tttcgctttc 3103741 agaaagctct tcaaagcctg tacctgactg aagctttccc catccgctaa atacatctgc 3103801 gtcaatgtgc ggaatgtttt ctttgtacaa atcgatatgt acaacttcat catttggatt 3103861 cgcttctttg taagattcga taaatgcttt acctgttgcc atactgtacg aagttgcttc 3103921 gtcatgtgga tgagcagtga tatataatac ttttgccatt tttaccagcc ctttcgtttt 3103981 taaaaatcac acatcaatta ttatcataca gatgcataat gattattctg tctctcttag 3104041 actttattat agagacaaag aaatttactt tcaagtaaaa catctcgaat taaagattat 3104101 ttaactttcc caaacagctt acttttcaaa agctgttctc aagccggaat acagcgcgga 3104161 caattcttta ctgatccgag gataatgagg gacatgcggc acttgaatat ccgcaggcat 3104221 ccttttcatg ataaaggatt gctcagcctg ttcaaaaaac gcccgcagct ggttgatctc 3104281 ttcatcagaa aacggagcag acggacggcg gtgagcttgc gccgagagca aatagtaccc 3104341 taagtgctga gcaccggaaa tggcaggcca gagcgcatcc gcattcgcgt gaggaaactc 3104401 gccaagcgcc ttgtcatacg catcccgaag cctgacaaga ctcaccctta acttgtgttc 3104461 gtcggcaatt tgcccggtta acagtttctc cataaactgc ccttccagcc ggatgacatt 3104521 ccgcacaagt tctggcagcc gcttggttga aaaccgccgc cacaaaagca ttgttcccaa 3104581 cagcccgatc acgctgccga cagctacatc agtcagcctc gctatcataa aataaccggc 3104641 gcccgccccg ccatgcatac tttctgtgat aacaagcgca tttgcggtta aaaagggaac 3104701 agccagcgca taattgcgga cgatcagcat ctcaagaaga cattgcagcg ctgcaataca 3104761 aaacgcaata taaacaccgc ccggcttaaa aaacaggatt gcgcctgcca gtataacacc 3104821 gatcaccgtt ccggccgaac gctgaatagc cctgtgaagc gtaaaaacaa cagtagtgcc 3104881 aagcatgacc gctgctgccg aaagcggaat ccaataggag cgtgcaaagc cgaatgcgag 3104941 ggcaaacata tcggcggcaa acagaacaat tccgtacttt aacgctctaa tcaaaactgg 3105001 agacttccag tcaaaggcat ttctcaaaaa gtaaaaagag gatggcaggc ggcttggttc 3105061 cccgtcaagc tgcttatcaa aacgtcctga agcgatatac aaaacctcat tgatttcttc 3105121 aaacagcttc cgcctaggct cagattcatt ttcattaatc tgaaacgtat tgaaaacccg 3105181 tgcattcgca agcatatctc cggtttggcg aagtgccttt tcaatctgcg cggtctctct 3105241 gtccggcgtt tcagctgaaa aatgaataat ggcaataaat atgtcgtcag ctttctcaag 3105301 gaggcgaaaa aatcgttcat catgccgcga ttttttccgt ctgttccctt tcccaagaac 3105361 cgtttggcgg gctgttctaa gcatgagcac cgtctgatgc tgtgcgttat gaaaacctgg 3105421 cgttccgacg gctgaaagac atgcagccag ctgatgatat gttttttgca gcaccgctcc 3105481 ctccggtcca tgtttgttcc ataaccagcc gattaaagcg atacccatgg cgaaaatgcc 3105541 gccgagaaac gtcagtcccg ctctgaacag cgcttgtgaa ggatcggccg gcagcccgga 3105601 actgactaaa aaggcaagga caaaaaacat cggcgcaggg ccttgaatgc cgagcgcgct 3105661 aaaaataaac atcgccgctg caccgatcag ccccaaaaca gccgccatca tccaaagcat 3105721 cccggacaaa agcgtcccta aaccaaatga gagggcgatc ccaatagaaa ccaagagcag 3105781 cttcaaggcg cgctttttgt acgattcacc gcccgcatat aaataaacaa agcctccgat 3105841 acttgcaatt aatccgtaat ccgtgtgacc tgccaatgca ccgaccagca caggaaaccc 3105901 tgaagcgaaa cctgatccga tagccttttt ccaaggaaat ggatttgcat gaatgcgaaa 3105961 ggcatccttc acgataggca tgattctttg attgttcgca gcagttttgt tcatttgaca 3106021 aaatcctttt caatgaatgt gtagaacttt tccagtttct tcgctttagt atgcccaaaa 3106081 acgcggttag cttctcaatt ggtgcgcacg ataaaaaaac agagacttat accgtctctg 3106141 cttcattaca tcagtttatt ataaaagcgg cacctgtcag gactgttttg tccttctgcc 3106201 ttccttcaag agcaggtgaa taaaaaataa aggataaatc aatagatacc cattaaacag 3106261 ccaccacaca agatcaaagt cactgctgaa tgtccagaat gatagcgcct gcagacctga 3106321 acaacaggtc agcacaagag aaatcagcgc catcagcttc cagtcagcac gattcacccg 3106381 ctgtaggtac aagctgtaca accctgtgac agaaatcagg atatccagcg gaaaaaaaga 3106441 ccagttccaa gcgatcataa acggatggtc atgatgttta aaagcccagc tttccggtat 3106501 gagcgaaaat ccggctgaca gccagtacaa gataaaaccg atatcagtca cgagaaaaaa 3106561 cagcttcata tatctcattt gtactgcccg cttttatgta ccggctcaga caccgcaaca 3106621 tgctcgatca ggtttaaaga cacaacaccg gcaataatca atccaattga aatgactttc 3106681 atgacactca catgttcttg aaaaaacaaa aaaccaacga ctgtaatcaa gacaattccc 3106741 atccctgacc atacagcata agcaactgat acatcaatgg atttaagcgt aagcgtcaga 3106801 aagaaaagac tccctccata aaagaaaatc aacagcaaac tgggaataag ctttgtaaaa 3106861 ccagacgata gcttcatgct gacagttccc gcaacctcaa acaaaatcgc caagcataga 3106921 aacacccaat tcatgtggca tcagcctcct catcagctgt tataccgtta aacaaaacat 3106981 ctacaattga ttcaagtacc tctcctgtcg tgaactgatg tttcagcgga tattcagggt 3107041 catacacttg attgatgctc cctatataca tgtgaacaaa caggtccgga ttgatgtttc 3107101 tgattctctt ttgctgtttg cactcattta ataatgctag gacaatcgcc cattcttcct 3107161 taataaacgc gtctaatgta agccacgcat cgtaatggta tttctttagt tcatttaata 3107221 atcccatgtt cagcagttcc atcccctgcg gaaggctgat cagcatttgt ttcacctttt 3107281 cgagcacatt taaactttca ttttcataga tgtctctttc tatttgcttc atttcagcta 3107341 taaattgttc gacaaccgcc tcaacaagct gatctttaga tgaataatat gcatagagcg 3107401 tccgcttgct cgttcccagc gctgccgcca aatcattcat cgtaaatgaa aatcctttct 3107461 gcttgatcag ccggaaggtt tccgccagaa ttcttttatc catattaatc ccccgctttc 3107521 ggtaccaaga aaactatttc ggtaccaata ttatacggca gaaatttatg gaaatcaaca 3107581 atatataaaa aaacctctcc tattgggaga ggtttaaaag acactgcgga ccaaaccgcc 3107641 gtccgcccga agtgccgcgc cattgatcgc agaggaaagc ggactgctta aaaatgtaac 3107701 gaagtgggcg atttcttccg gacggatcag tctttgaata atagatgtcg gccggttttc 3107761 tttcataaaa cgtgcctcag cttcttgaac agtcaggttt tcaccaggat acagcgagtt 3107821 cagcatggtt tccacaccct ctgttaaggt agagcccggc atgacggtgt tgactgtgac 3107881 attcgtgccg gttgccagct ccgccaaact gcgggaaatg gacagctgca tcgtttttgt 3107941 cgcactgtaa tgggccattt cctgtgacgg cataatcgcc gcttcactgg caatgaaaat 3108001 cacacgccct tcttttttct ctatcatgtt atgcaaatac ctgcgtgtca gccttacacc 3108061 gctcataata ttcacttcaa aaaaacgaaa ccattcatcg tcgggaatat caaagtactc 3108121 cgccggttca aaaatcccta aattgttgac caaaatatca acctctggat atgcctgaaa 3108181 cagctcattg cagccttctt ctgttcccaa atcaaatgca gccggataaa gaaccgcttc 3108241 agcatgttgt gttttcagtt catctatcgt ttgattcact ttctcttccc ggcgtccgtt 3108301 aatgatcact gccgcacctt cttcagctaa cgaagaggca atagcttttc cgatccctga 3108361 tgtcgaaccg gtcaccagtg cggtttttcc ttgtaaattc agcttcatta ttcatccctc 3108421 cgtttttgat tcctcttatt tattgacaga aatctgattg gtgaaacatc tgctctgcaa 3108481 tcagtatgaa acagctggga ttgaaatgga agtacgcact ttttggtgcc tgtggtttgg 3108541 agaaaaaata aagcagaacc tcttaagagg ttctgcttta ttgtcagtat gtatggagac 3108601 ggtgggagtc gaacccacgt ccagaaacat cgattactta agcgtctacg agcgtagcct 3108661 gcatatttat ggtttcactc atcttcttgc ctgcgggcgg gccttccgag agctagtctg 3108721 ttcatctctt cttacgttct cagacgggaa cgcaagcgta gcctacttgg atgtgctctt 3108781 cacagacaca taggcaatgt caggaagagc tcgctgcgct tattaggcag ctaatgctac 3108841 gttttggtta aaactgttag ttttgccagt tatatttaag tgcgtgttta cgagatcgcc 3108901 tctcggctcg cagctcaagc tcgatccatc cctgtcgaat ccgtaacgtc cccttggtat 3108961 aagggaaata cgggagaaaa tatcaagctc tcactcaaac tggctatagt cttattataa 3109021 catgatcacg gctcttttca attgtcaaat ccttcaaatg aatggcgtcg tgatctgatc 3109081 gtgaacacag tatagcacag gcctgatttt cgaatcaagc actatgcctt tagaagcctt 3109141 tttgactgtc tctgaacgct ctttcgattt cccgcttcgc gtccttgcgc ttcagatctt 3109201 cccgtttgtc atagttcttc ttcccttttc caaggccgag aagcactttg gcaaagccgt 3109261 tttttaaata cagcttcagc ggaacgagag aatagccttt ttcctttgtt aacccgatca 3109321 gcttattaat ctccttgcgg tgcattaaca gctttcttgt ccggagcgga tcgtggttat 3109381 agcggtttcc ctgctcatat gggctgacgt gcatattgtg gagaaacact tctccccgtt 3109441 cgattttggc gaaggaatcc ttaaggttta cgcggccggc gcgaatcgat ttgatttcgg 3109501 ttccttgcag aacgatgcct gtttcatagg tttcttctat aaaataatcg tggttggctt 3109561 tcttattttg agataatact tttcctgacc cttttggcat gccagaacct cctctctcta 3109621 aggaaaaact gtccaccttt tgcgatacgc tctattttac caaatgtcac gtaccgctac 3109681 aatgaaaagc tgtttccgaa agaaagcaaa tagagcgctg cggccctatt tgctggttga 3109741 gctgctattt cttctttttc cgtttctgtt tcggagcatt ctggaagccg cgttttttct 3109801 ttttcttctt cggcttagtg aaccactccc ctttttcctc agacggagct ggagaaacag 3109861 gtgtattggt gctttgaaca cgttttctgg caggctttcc gcgttttctg ctccggctgc 3109921 tgtccaattc tctcggacgc cgcggagtgc ctttcatgcc gacaatttca aagtcgatat 3109981 tgcgctcatc tttattgaca tcgacaacct tgactgtgat ttcatccccg atgcggaaga 3110041 cgttgcctgt ccgctcgcca atcattgcga aatgctgttc gtcaaagcgg tagtagtcat 3110101 ctgtcataaa gctgacatgg acgagtcctt caattgtatt cggcagctcg acgaacattc 3110161 cgaagtttgt cacagagctg atcatgccgt caaactcttc accgatttta tcaagcatgt 3110221 attccgcttt tttcagatca tccgtctcac gctcggcgtc aactgcacgg cgctccatag 3110281 atgatgtatg ttcggcgata tccggcaggc gttcagccca cttttcctgt gtcgcttcat 3110341 cgaccttgcc gttgatcaaa tacgttcgga tcagacggtg aacgattaag tccgggtaac 3110401 ggcggatcgg tgatgtgaaa tgcgtataga attccgttga cagaccgaag tgccccaagc 3110461 tttgcgggtc gtatttcgcc tgtttcatcg aacggagcat aacagtagat ataaccgttt 3110521 cctctggtct gtcacgcaca gcgtccagaa tgctttgcag cgcgcgcgga tgaatattcc 3110581 ccgccgttcc tttcaccaca tagccaaatg tcgtcacaaa ttctaaaaac ttttgcagct 3110641 tttcagcatt cggctcttcg tgaatccggt atataaacgg gacattcatc caatggaaat 3110701 gctccgcaac tgtttcgttt gctacaagca taaattcttc aatcagcttc tcggcgacag 3110761 agcgttctct gatcacaacg tctttaaccg ctccttcgtc atcaacaagc acctttgctt 3110821 ctttgaaatc aaagtcaacg gcgccgcggt ccatccgctt atcgcgcaga atttgagcca 3110881 gacgctccat gtctttgaac atcggaacaa gaggctcgta tttttgtttc agctcttcat 3110941 catcatcaac aagaatttta ttcacatctg aatatgtcat tctttccgtt gttttgatga 3111001 cactttggaa gatctcgtgc tctgtcacct gtccctgact gttaattgtc atttcacaag 3111061 aaagcgtcag gcggtcaacc tttggattta aggagcagat gccgtttgac aatctgtgcg 3111121 gaatcatcgg gatgacacgg tcaaccagat acacacttgt ccctctttca agcgcttctt 3111181 tgtcaatcgg cgagttttcg gttacgtaat ggctgacatc agctatgtga acgccaagct 3111241 tgtagcttcc atcatcaagc ttcgtcacgg taactgcatc atccaaatcc ttcgcatccg 3111301 caccatcaat ggtgacaatc acctggtcac ggagatcacg gcggtctttc agatcttttt 3111361 catcaatcgt gtcaggcgta cttgatgcct gttccatcgc gtcagctgga aattctcccg 3111421 gcaggccgtg cttatgaatg accgataaaa tatcaatgcc cgggtcgttt ttgtggccga 3111481 gaatggtttc aacctcaccc tctgcgttca tgcggccttc aggatagctc gtcagcttga 3111541 caacaacctt atgcccttcc gcagctccat ttttcccatt tttcggaatg aagatgtcac 3111601 tcgtgatttt tttgtcgtcc ggaatgacaa agccgaagtt tctcgtttct gtatacgtgc 3111661 cgacaacccg ctgaatcgct ctttctaaaa tccgtatgac ggttccttcc tgcctggagc 3111721 cgcttgattg tgagttcaga cgcaccatga cgatatcgcc gttcattgcc gtatttagct 3111781 cattaggcgg aataaacaca tcacttaacg acgtatcctc aggcagcaaa aaggcgaatc 3111841 ctttcgcatg ggctgaaatc tttcctttta ttaaattcat cttctccgga atgccgtagc 3111901 ggtcgcttct cgtccgtacg ataagccctt tttcttccaa ggcgactaac gctttgacga 3111961 gctctttaaa ctcctcggct tccgtaatat ttaacatctc ctcaagttcc tgaacggtca 3112021 gaggtttgta cgcctcttcc ttcataaacg agagaagctt ttccataaat gcttcttttt 3112081 ccattatccg acctcctgtt gattaccaat cgagcttctc taaaaattca tacacatcct 3112141 gatggacgag gtcacgttct ttgtcgagtg taatgacatg ccctgattcc tcgtaccatt 3112201 tcagctgttt atcatcagtt tccacttcgt tgtaaataat attggcgctt tcggtattaa 3112261 tcatgtggtc atgacgggcc tgcaccacaa atgtcggtga ataaatcata tcgacattat 3112321 tccgcacatc agcaattaag tcttgcagcg ccttgagggt attcatcggc gttttttcga 3112381 attctttcat ttcctcttca atttgctccg ggcttttccc ctcaaacttt ttgtaattgc 3112441 gagcgtatga aagaacgcct tgatacatga cctcttcact cttaatatgc atcggtgcgc 3112501 acattgggac aattcccttt atgggtacag tgtaacccaa tttcagcgaa aaaaccccgc 3112561 caagcgacag tccgcaggca gcaatgctct cataaccttc agattttaaa tattcatagc 3112621 catccattac gtttttccac cagtcttcgg gccccgtatg tacaagttct tcaggcggga 3112681 cgccatgtcc ttcatattga ggcgcgtggc acgtatagcc gcgttcattc aaatatcgtc 3112741 ccagcatcct tacatccgct gtatttcctg taaagccatg cagcaaaagc accgctttgt 3112801 ctccgccttt aaatgtaaat ggttttggtg tcacaacttt catgctcatg tctccctttc 3112861 tatctgcacg atcattttag ttttccacag tttaatcaga aaaaaacgtt ttgaatatca 3112921 tccagaaacg tgaaaaaggc ctgacttcac atcagacctt atacaaacat tgccctatag 3112981 gatataagca agcgcaatcg ttaacacgaa aaacaagact gccagcacta ccgtaatgcg 3113041 gtgcaaaatt aaatcaagac ctcttgcttt ttgtttcccg aagagctgct ccgctccgcc 3113101 tgaaatcgca ccagataatc cggcactttt actggattga agcaaaacga caataataag 3113161 tgcaatgctg acgataacca ataaggtaat caaaactgcg tgcatcccat acacctccag 3113221 actcactggc tacattactt ctattttaca tgaaaagggt tggcatgtca cgctgtatca 3113281 gacgccaaaa ggccggataa gacgttttat cttggttacc ctattcatat gaaaaggtca 3113341 aaggagaaaa gcgatgccgc ttatcagcat agacagcagg aaacatcttt tttatgaaga 3113401 atatggacag ggaatcccta tcatttttat ccacccgccg ggcatgggac gaaaggtttt 3113461 ttattatcag cgccttctat ccaagcattt cagggtgatt tttccggatt taagtggcca 3113521 cggtgatagt gatcacatcg atcagccagc gtctatttcc tattacgcaa acgagatcgc 3113581 gcaattcatg gacgctttgc acattgataa agctgtgtta ttcgggtatt ctgccggagg 3113641 cttaatcgcg cagcatatcg gcttcacccg cccggacaaa gtgtcacacc ttattctgtc 3113701 cggcgcctac cccgctgttc ataacgtaat cggccagaag ctgcacaaac tgggaatgta 3113761 tctgcttgaa aaaaaccccg gtttgctcat gaaaatcctc gctggcagcc acacaaaaga 3113821 cagacagctt cgcagcatat taacagacca tatgaaaaaa gcagaccagg cccattggca 3113881 tcagtattat ctggattcgc ttggctacaa ctgcattgaa cagctgcccc gcctagaaat 3113941 gccaatgctg tttatgtatg gcggcctgcg ggactggacc tttacaaacg caggctatta 3114001 ccgaagatcg tgcagacatg ccgaattttt cagattggaa tatcagggac atcaattgcc 3114061 gacaaaacaa tggaaaacgt gcaatgagct ggtgacaggg tttgtgctga cacatcattc 3114121 ataggaatag aaaacgcttg gcttccttgc gttttttgtt actttattga cttttgtcaa 3114181 cgaaatcata gtaaaaaaga tcctcaaatt tcaaattaaa atagtgaagc attttaccaa 3114241 tcacaagctg ccccggcctt ctttctccat tcagcacgcg gctcagtgtg gcgggtgaga 3114301 ctccgatttc cagcgcaagc tgattaaggg aataatcgtt attaaccata tactgcaaga 3114361 cataatcacg tctaatctgt atcttttcta ctggcacttt cctcaccttc cattcctgaa 3114421 aaactttttt ctatactttt acattacggc ttatgttaac ttttgtcaat acatttccag 3114481 tctacctatt ccctttagtc aataaacata ctaaaatatg agtaacagtg agggacgggg 3114541 tgagatatat ggaaagcttt ggcgaacaat tacgggcatt gcgtgaagag agaaagttaa 3114601 cagtcaacca gctggcgact tattcaggcg taagcgcggc cggcatctcc agaatcgaaa 3114661 acggaaaacg gggcgttccc aaacctgcca ccatcaaaaa actggcagag gccttaaaaa 3114721 ttccttatga ggggcttatg tacaaggctg gttacatcga agaagtgcat gaagccaggg 3114781 ccccttatga aacgaagtgc aagctgcttg aaaaagcgga ggcctatgac ctgaaaaacc 3114841 ttgcgcttct tgagaacgaa aagtggcaat atctcaataa agaagatttg ctcatgctgg 3114901 atcattattt ttcgtttatt tcagatgaag cgaaaaaacg gtctgctgat gactgactct 3114961 tgatagaaat gtgaggcgat agaccatgtc accgttcgga cagcaattac gggagctgcg 3115021 ccgcgcccgc aaactgacag tgaatcagct tgcggtgtac tcaggcatca gctcggccac 3115081 catttcaaaa attgaaaacg gcaaacgcgg gacgccaaaa cccgccacga ttaaaaaact 3115141 ggcagccgtc ctgaaagtgc cgtacgaaaa cctaatggcc gccgcaggcc atattcaggc 3115201 ctttcctgaa gaaatccgcg aagcatctga aggctatcaa tccgtttatg aaatttacca 3115261 gacggctgtc acacgcggag cggagcacct cccgattttc aatagtcaaa aatgggaaca 3115321 tctctcaaag caggatattg aaaatctcag caaatacttc gattttttgt cttcagaagc 3115381 aaaaaaacgc gcctcttcct cataatcccc tgtttctctt tctatatttt atcaatcacg 3115441 cttgcatgcc ctccctcgtt atttgcgtta taatagtgac agacgaggtg aaaagtatga 3115501 accaatcaga aatgtgtcct agatttgaaa aagcagtcga catcttaagt aaacgctggg 3115561 tcgctttaat cgtatttcag ctcttgaacg ggtcgcagcg atttagcgaa attgaagcag 3115621 cacttccaaa tctaagcggc agagttctgt cagaacggct gaaagaactt gagcttgaag 3115681 gagtagtgaa gcgggatgtc atccctgaaa ctccggttcg catcgaatat tcattgactg 3115741 ataaaggaaa ggcactagca cccatattag gtgagatttc taaatgggcg actgaatgga 3115801 ttgacccttc ctttcttgac taattgctaa aatggttctg atctcaaaga cgagaaaaga 3115861 accgtttttt attttccagg tgaaaaaaag atatctcagc cgatatatag tacatccaca 3115921 cattacgttt ttaaaggaga ccactatatg cgactgacga tttcccgcaa attcagcctg 3115981 gtatttttga cactgatcct gatcaattta cttgtaggcg gaataggcgt tcttaatatg 3116041 cagcatatca ttcaaaaaac agatgaaatc aacacaaaat ggattgacgg catcaaagga 3116101 atcacttcaa ttaattatgt aaccgagcac ctgtcttcta aagaaaagga ctttctgatt 3116161 tatacagaca aaagtaaaat ggatacactt gatcaagaaa tgaatcaaat catggaagac 3116221 attaaccaaa agctcgataa ctacgaaaaa acgatctcca ctgataaaga gcagaaactg 3116281 ttcgagcagc ttcaaactaa agtgaatacc tatatggata ttcatgcgca aattatcgaa 3116341 agcggccgca cgaatgacat ggacaaagca agaggtttat tggttcagac tgaggccagc 3116401 tttgaggata tgaaaaaaac aatcactcag cttgttgact taaatcaaga aggcagcaac 3116461 acagcggtaa aagaaacgaa ggccgtctat cataaagggc tcatttacac tgctttgctt 3116521 gtggcagcat caatcctcat cagcattttc atctggcttt atatcacgcg aaacattgta 3116581 aagcctatca ttcgcatgaa ggaatctgcc aatcatattg ccgaaggcga tttgtcgaac 3116641 gatatggagg ccctcaactc aaaagacgag ctgggtgatc tgaatgaagc gctgcaaaaa 3116701 atggtaggga atctgagaga tattgtcgga tattctaaag acatatcaag ccgggttctt 3116761 tcttcttcac aggtgcttgc aaccgcaacg aatgaaacaa gatccggcag caaacatatt 3116821 accgagacga tgaacgaaat ggctgagggc tctgaacagc aggcccaaga cgcggtgacg 3116881 attgccgaat cgatgaatga gtttaccgaa agcattgata aagcctataa tcacggcatc 3116941 acaatcagcg atacgtctca aaacgttctc gaactcgcgg taagcgggaa cgaaaatatg 3117001 gctacgtcat tacagcaaat gaaaaccatc catcatattg ttgaagaagc cgtgcataaa 3117061 gtgagatcac tggaacagca ttctcaggat attaacaagc tcgttcaggt catcaacggg 3117121 attgccgagc agacgaattt gctgtccctt aacgccgcga ttgaagctgc ccgcgctgga 3117181 gaaagcggca aaggcttcgc cgttgtggca gaggaggtca gaaagctggc tgacggcgtt 3117241 tctgattccg tgcaggacat tacccggatt gtaaacggga cacagcagga gatccacact 3117301 gtcattacgt acttggaaag cagctttaca gaagtcgaaa aaggaacgga aaacctgaca 3117361 gacaccggac aggctatgca gcatatcaaa caatccgtca cccatgttgc agacagcatt 3117421 aaggaagtaa cggatggctt gaagcagtta acaaaccaat cgattaccat caatcaatcg 3117481 attgaaaata tcgcttctgt atccgaagag tctgccgccg gcattgaaga aacattttca 3117541 attaccgagc aatccgccca ttcgatggat caagtgcttc taaatgctga agagcttgag 3117601 cagctggcca atgagcttaa tgagaagatg ggtcagttta cgatttaaag agaaaaaaga 3117661 ggctggactc cagcctcttt ttctattcta tgcagctgat tgaacatgtt tcgccccggt 3117721 tctttttttc ttcaccggac ttaatgcccg ctccagccaa gccatgagca aatccgcccc 3117781 taccgccatc accgcagttg gtatcgctcc ggctagaata atcgcagttc cgtttgttgc 3117841 gtttgagccg cgtacgatca tgtccccaag gcctccggca ccgacaaatg tgccgatcgc 3117901 tgtaattccg atggcaatga cgagagccgt gcgaaggccc gccataatga cagaaagtgc 3117961 gagcgggagc tcaaccattc tgagcacttg gaatttcgtc atgcccattg cttttccaga 3118021 ttctaagtag gcatgttcaa tactgataat gcctgtgtac gtgtttcgaa taatcggcag 3118081 cagggaatac agaaataatg atagaatcac ggtatttgcg ccgagcccca taacaagcat 3118141 taagacggcc agcatagcga gcgccgggat tgtttgaata acgtttgtta cggcaaacac 3118201 ccaggctgac aaacggcgaa aatgcgcgat gaggattccg gccggaaccc cgacgacagc 3118261 ggcaaataaa acgccgtaag ccgacatgag aaagtggcgg ccgaattcat ccatgacgta 3118321 actgccattc tgcgcgtaat acgtcattaa ctgttcaagc acgttcattg acctcttccc 3118381 cctttcacga ttcgaaatag cgatgttttt ctaaatattc cttggcaacg acagacggtt 3118441 ctttgagatt gccgtcgact tcatagttaa gctcctgcat cgtggctgtg tcgatttttc 3118501 cgagcatttt cttgatgatg ccttcaagtt caggatgttc tttgagcacc ttttccggaa 3118561 caaccggaga gcagtcgtac ggcgggaaaa attgtttatc atcctttagc attttgagac 3118621 cataggactt gattcttcca tcggttgaat acgcaagcac aatgtccatt tttccgcttt 3118681 tcaccgcgtc gtacacaagg ccgatctgca tcggatacgt gccgccgaat gtcatgccgt 3118741 aggttttcgt aaaatcctga tagccgtttc ctttgagctt catccaatag ttatcaacgc 3118801 ccagctttaa ttgcggcgcc cattttttaa cgtctgatac ggtctctaaa tggtattggt 3118861 cggccagctc cttgctgact gtaaaggcat atgtattatc aaacccgtag gagtcatacc 3118921 actttaaatc atatcttttt ttaaactccc gctgagtaag cgccagcgct ttgtccggat 3118981 ctttttcagg ttccattctc aacgtgcctg tcagcgcgtc tcccgtatat cttgtggccg 3119041 caatgtcgat ttccccgttc attaaagcct gctgctgcac cgcgttggag ccaagatttt 3119101 taatcgttgt tgttttgaga tcagtatggt gttcgatcaa ctggccaagc atgctggcga 3119161 tgatttctga ttcgctcatg ctttgcgcgc cgattttaat ggtctggtct gcagcagcgc 3119221 tgagaccagg aagcgaacag ccgctcagcg tcagcgttgc cgcaagtgct aaacctatca 3119281 ttaatttgag atattttctt ttcatgagcc gcctccttat gacaattcct tcaatctctg 3119341 catgccggca ggtgtcagtt ttcgttcagc aactgccagc acataatcaa tcacaattgc 3119401 caatatcgtg acaggtaccg cgcccccgat gatatattcc ggctgatata aattcagtcc 3119461 gataaaaatg taatcaccca atccgccgcc tccgataaag gaagcaagcg tggcccagcc 3119521 gattaagtaa atcgtcgatg ttctgattcc cgccatgatc actggtgcgg caagcggcag 3119581 ctccaccaag cggacttgtt cagccggcgt cattcctatt cctttaccag actcgagcag 3119641 atttttgttg acgccgcgaa tgccggtata cgtgttgcga agaatcggca atacggaata 3119701 gaaaaacaaa gccacaatgg ccggaacctt ccctacacca aggagcggga taaaaaaagc 3119761 gaggatggcc agactcggca gcgtctgaat gatattgaca atgccgataa tggtgccggc 3119821 tccttttttc attctggtaa gcacaacccc gagggggacg gcaaccagca cacctaagat 3119881 cacagcaatg agcgatatcg taatatgctc gtatgtttta taaagaagct ctcccccatt 3119941 ggtttgcaaa aattgaacaa tatgatgcat gacttatcgc ccctccctat gacaatgctg 3120001 cgagctgctt ttcttctccc cagagggagt catacacgat gtcgaccaga cttgccctcg 3120061 tcacaattcc gatcaggcgt cggtcttcat ccacaacggg aacatatttg acaccccgtt 3120121 ttaaaatttt gcggaccgtg tcgcgcagca gtgtgccgcc cagtactgtg tatatatctt 3120181 catgtaaaac ttcactgacg agattggcct ttttccggca ttgatcaatg atttcaacat 3120241 cgacatagcc ttgcagaacg cgctcgtcat tgacgaccag caatgaatcg acccgttcct 3120301 gcctcatcag ctgaatggcc tcagaaagcg ttttatccgc ggtgatcgtt acaggctgtg 3120361 tgttcataat ctggtcaacc cgttcaacat ccgggctgga tgactgaatc agccgctcct 3120421 tgccgataaa ttcctcaaca aattcgtctg ccggatttct taaaatgtca tcgggcgttc 3120481 caacttgaac gatttctccc gcttttaaaa tcacaatccg gtctgccagc ttaatcgctt 3120541 catccatatc gtgggtaaca aatacgatgg ttttatgtaa ggttttttgc agttttttaa 3120601 attcttcctg gagggaatcc ctcgtaatcg ggtcgagtgc cccaaacggt tcatccatta 3120661 agataagcgg cggctccgcg gcaagtgccc gtaatacacc aattcgctgc tgctgccccc 3120721 cgcttaattc atgagggtaa cggtctacat attctggccc catatcgacc aattttaaaa 3120781 gctcacgcgc ccgctctttc cgctgctgct ccggccattt cagcagtttt gggacgagtg 3120841 agatattctg ctgaatggtc atatggggaa acaggccgat ctgctgaatc acatagccaa 3120901 ttttgcgcct gagctctaca ggatcctggt ccatgatgtt ttcgccgtca atgaaaatct 3120961 tcccggcgga aggctcaatt aatcggttaa tcattttcat tgttgtcgtt tttccgcagc 3121021 cgctcggccc gataaagcag ataaattcgc cttttgcaat cttaagattt acgttgttca 3121081 cggctttttt gccgcccttg tatgttttcg agacattttc taatgtcagc aaacatcgca 3121141 cctccaaaat taagtttatt caatttgttc agtttaaatt taatttttca gacaattgaa 3121201 tgcttcccat tatagaataa agtttataaa ataaaaagtt tacaatttgt tcatattatt 3121261 tataaagtat gtgtaaacgc tgatttaccc gcattgacgt gtgttgatct ccttattgct 3121321 ccaatttcct gccaaattct cttttgacag cattttcgcc gtatcaaaaa tgtggtatat 3121381 tgacatcgga attgttagct gaaaggatga aaccgttgga gaaagatccg ttaacgatca 3121441 ttgaacaagc cgaggaccat tttatagaaa gaatcgcgga aaacatgcat gcatttggaa 3121501 tgccctctac cgtcggacga gtgctgggca ttatttatat gaatcgaaaa ccgatgacgc 3121561 ttacggaatt atctgaggcc accggcatga gtaaaacacg tatgagccag gtagtgcggg 3121621 aaatgcttga tgccaacatt gccgagaagg tattcgaaaa aggcgtgcga aaagatttat 3121681 atgaggttga gcaggactac tatcaaacat ttatcacgct gttttcagcc acctggagca 3121741 aagtcgtcag caaaaacaaa atgatgcata aaaaactcaa tcgggagctg cttagcgtgt 3121801 tggatgaaga gcttactcct gaagcggaag aaaaagtgaa tgagctgctg aaggaattaa 3121861 aggaatggct cgattattat aattggctca gccgtttgat tgagtttttt gagagcgaag 3121921 acatttttaa atatgtgccg aagccgtaaa aagttcccaa attcaattct gggaactttt 3121981 ttaagtccaa tccaaatggt tgaatatcaa acttcaagaa aacaaacaaa ataatgcata 3122041 atttacatta atttattaat tatccatttt ttgttgatta ttctgactag ctattatata 3122101 atctttttga aatgattata ttagcttaga ggaggtaatc tacatcaaaa aaaagggaat 3122161 tattactgta atgactatat gtttcctatt attttcttct tattacttta gcaatatttc 3122221 acctcagaat ccactgttca aaaaaaattt tttgcaacaa ttgtctcccc aaggctttgg 3122281 cttttatagt aaaagcccta cagaagaaaa catttcattt cacacaaaag aaaatttaaa 3122341 gttacctaat gcacttccca ataatttttt tgggataaaa agagaaggaa gagttcaggc 3122401 aatagaatta ggcaaaattg tagagaatat cgatccaaag aattggaaaa cttgtgaaaa 3122461 caacaactcc tgcacaaatt tagagaaaca aataaagcct attaaggtta taaaaaatga 3122521 agattatata catcttagca aaggagaata cctaatatat cgccaaaaac cactctcatg 3122581 gtattggata gactttaagc aaactacctc ttttgaaaga aaggtgctaa aaataaaaat 3122641 agtatgaaga tattaaatag tttagaaggt tatattgaca cctataatcc atggaaaaat 3122701 acatatgcac tttttagaag tttacttggt ttctcaacat tactagtact attattcaat 3122761 agtactgata ttttatttag ttatagtgca aataatgtca catgtgaaaa tgtctatatc 3122821 cctaccgctt tttgttttgc taaagaatat agtatcaatt ttgagattat aagatactta 3122881 atgattttta tattaacctt agtggttata gggtggagac ctagatttac cggtttattt 3122941 cactggtata tttgctatag tattcaaact tcagctttaa ctatcgatgg tggagagcaa 3123001 attgcaactg ttctttcttt tcttatatta cctgttacat tattagattc aaggcgaaat 3123061 cattggaata taaagaaaaa caataatgaa tctttcacaa agaagacagt attgttttat 3123121 ataatgacaa taattaaaat tcaagttttt atcatttatt taaacgcagc tttagagcga 3123181 ttgaaaaata aagagtgggc agaaggaaca gcaatttact atttcttttc tgatccggtg 3123241 tttggattac ctgaatatca acttaactta atgaatccac tacttgaaag caattttatt 3123301 gttgtcatca cttggttagt aactattttt gagttgttct tagcagcaag cataatttca 3123361 aatatcagaa taaagagaat tgcccttgtt ttgggaatat tatttcatat tgggataata 3123421 ttcagcattg gtattgtaag ttttggcttg atcatgatat cagcattaat tatatatctg 3123481 catcctgtac aacaaaatat cactatgaat tggtgttctc ctttatttaa atatatatat 3123541 gtaaaaggaa agagaaattt caaaagaata ggaggtgaat cagtcaagtt tcttacaaaa 3123601 ttgtttcata gctaacattt agataatgga gaaataactt aatggaggta taataatttg 3123661 aaaagtaaat tacttaggct attgattgtt tccatggtaa cgatattggt tttttcatta 3123721 gtaggactct ctaaggagtc aagtacatct gctaaagaaa accatacatt ttctggagaa 3123781 gattacttta gaggactttt atttggacaa ggggaagttg gtaaattaat ttcaaacgat 3123841 ttggacccta aactcgtaaa agaggcaaat agtacagaag gtaaaaagtt agtaaatgat 3123901 gtagtcaaat ttataaaaaa agatcaacca caatatatgg atgaattgaa acaatcgatt 3123961 gacagcaaag accctaaaaa actcattgaa aatatgacca aagcagacca acttatccaa 3124021 aaatatgcta agaaaaatga aaacgtaaaa tactcttcta ataaagttac tccatcttgt 3124081 gggctttatg ccgtctgtgt agcagctgga tatttatatg ttgtgggcgt taacgcagtt 3124141 gcattacaaa cggctgccgc agtaacaact gcagtgtgga aatacgttgc caaatattcc 3124201 tcttcagctt ctaataattc tgatttagaa gcggctgctg caaaaaccct aaaattgatt 3124261 catcaataat ccattataat tgagtgtctt gcggattgct ccgcaagaca ctttttcaac 3124321 gtgaaccgtt taattttttg taataatgat atgaagctag tgttgaaata actaatgcta 3124381 gaagaactag cacaatcata ataagaatta tatattctcc tgtaaaaaat gaaagaacag 3124441 ctattataaa accacacact acaagtactt tagaggcaaa gcgatttccc agtttccaaa 3124501 cagtctcatc ttttaatgtc caaggtgtcc tcaatccaat aagatggttt tgttctgcta 3124561 gctgcataga atttccacca ataattaaaa agataccaac accaagccct attattaaat 3124621 caatattcac ttcgtatcct aaacttatca atagagttga gagttgtaaa atatataaaa 3124681 ggattaacat attattagaa gctaggaaaa gcaatgcttt atttttttgt gtagacttaa 3124741 tagttaacat ataaaaagta agataataaa taagcataac aacaggtata ataaatattg 3124801 ttaaaggttt agatacaatt gcagccggtt tatttcctga ccattgtatc ggtatttctt 3124861 ctggaaggta ttgatataat ataattgaag tcaagaaact caaacataca ataattatgg 3124921 aaattatatt tttcttcata aatcgttatc ccctttattt ataaagttaa gcatccaatt 3124981 tattgagtct tgaagtactg ttgtatttag agagtaataa ataaattgtc ctttgcgatg 3125041 gtcacttatg acttccgctt gctttaaaat attcaagtgg tgcgaaatac tcggtttgct 3125101 gatattaaaa tgctcagcaa tatctcccgc agtcatatcc cctcctttta acaaatccaa 3125161 aatttttctc cttgttggat ctgatatagc tttgaaaaca ttattcatag cgttttctcc 3125221 tttacaaaaa aacatttaga catttagata tttgtataaa tgtattattt tcattataac 3125281 ttgaattttt ttaaaaacaa ccctcaaatt ggttataata tctgattttt gtattttttc 3125341 aaatactcgg ataatcccaa cgctggaaaa tatgtttaac agatactaac acatgttgtt 3125401 tatttaaaaa aaccacctct gttgtattta aatagaggtg gtttttctat cagctataat 3125461 aaaatttcct tttttctttt taatcgggct taatgctcgt tcaagccagc ccatgaccaa 3125521 atcggcaatc accgccatca gagctgtggg gatcgctccc gctaatataa tcgcggttcc 3125581 gtttgtggcg tttgatcctc tgacgatgat gtccccgaga ccgccagcac cgacaaatgt 3125641 cccgatggcc gtaatgccga tcgcaatgac aagcgcggtg cgcaggccgg ccattatgac 3125701 agaaagcgca agcggaagct cgaccatccg cagcacttga aattttgtca tccccattgc 3125761 ttttcccgat tcaagatagg cgtgctcaat actgataatc cctgtatacg tatttctgat 3125821 aatcggcaga agagaataca gaaataatga caatatcacc gtattagcgc ccagccccat 3125881 gacaagcatc agcacggcga gcatggcgag agccgggatg gtctgaatga cattcgtgac 3125941 cgcaaaaacc catccgctta atcttctgta tctggctatc aggatgccga gcggaattcc 3126001 aacaatggcg gcaaataaaa cgccatacac cgacatcaga aaatggcggt aaaattcctg 3126061 cagcacgtaa ccgccgtttt gcgaatagta tgtgccaagc tgctgtagta cttccatatg 3126121 atccacctct tttcttagtc aaaataatga tgtttctcta aaaattcctt tgctacgaca 3126181 gacggctcct tcagcttgcc atccacctca taattaagtt cctgcatcgt ttccgtgtcg 3126241 atttgcccaa tcagcttatt gatcacacct tcaagttccg gatgctcctt aagcaccttt 3126301 tccggaatca ccggtgaaca gtcatacggc ggaaagaaac gcttatcgtc ttttaagatt 3126361 ttcagatcat atgctttaat ccgtccatcc gttgaataag ccaaaaccgc atccattttc 3126421 ccgtttttga ctgcgtcata gactagcccg atctgcattg gataagttgt gccgaactca 3126481 aagccatatg tgctgacaaa gcctttatac ccgtcgcctt ttcgtttcag ccaagcattg 3126541 tcgacgccta atttatattg ggaagcattt ttcttcaggt cagacacggt gttaatatgc 3126601 tccttttccg caaacttttt tgttacggtg aaggcatatg tgttatcaaa gccgtaggaa 3126661 tcaaaccatt tataagaaaa gcgcttttga aactcgttct gcacaatgtt cagcgctttt 3126721 ttcggatctt tctccgcttc cttgccgagg gtgcttgtta aatctgttcc ggaatagcgc 3126781 gtggctgaaa tatcaatgtc accgcccagc atcgcttggt gctgaacata gtttgagccg 3126841 aggtttttca ctaaagcagt attcaaatct gtatcatgtt caataagctg cgcgatcata 3126901 ttcgctacaa tttctgattc tgtcatgctc tgcgccccga ttttgatcgt atcgtcagaa 3126961 gcgccgccta gacccggcag agagcagccg cctagcagca tgacaaagac gagagcaaac 3127021 gcgccaagcc atttgatttt tgtcattttc aacagtgcca actccttacg atacttcctt 3127081 catcccttgc aagcctttcg gcgtcacctt tcgttctgtc acagccagaa cataatcaat 3127141 aataattgcc agaattgtga caggcacggc accgccaatg atatattcag gctggtatag 3127201 gttcagtccg ataaaaatat agtccccgag gccgcctccc ccgataaacg acgcaagtgt 3127261 cgcccagcca attaggtaga tcgttgatgt gcggatcccc gccatgatga tgggaatcgc 3127321 cagcgggatt tcaacgagcc gaatctgctc ccagccggtc atgccaattc ctttccccga 3127381 ttccaggagg tttttattta cacctttaat gccggtatac gtattgcgca ggatcggcag 3127441 taccgaatag aaaaataaag cgacaatcgc aggcactttt cctacgccga gaagcggaat 3127501 aaaaaaggct aaaatcgcca gactcggcag ggtttgcaca atgtttacga aaccgataac 3127561 cgcacctgcg ccttttttca ttctggtaag agcaacgccg agcggcactg caacgataat 3127621 gcccaataca acggctatga gtgaaatata taaatgctct cctgttttat acagcagctc 3127681 tccgccgttc gtttgcaaaa aagtcatcat ttgattcatc ttaaaagagc tcctcccctg 3127741 gtcagatcgt catgagctgg ttttcctcgt cgccccaaat ggaatcgtat acgatatcaa 3127801 cgaggctcgc tcttgtcaca atccctgcta aatggttctg ttcatcgacc accggaacat 3127861 acttgatccc ctgcttcaaa atttttcgga ctgtatcgcg aagaagcgcc cctttttgaa 3127921 cggtatatat atctgaacgg tatacatcgc caacgatgct cgcttttttg cggttttgat 3127981 caatcatttc cacatcaaca tagcccttca gcacgttttg ccggtccaca acgagcagcg 3128041 agtcaacacg tttttctctc atcagctgaa tcgcctgaga aagcgttttg tccgcagata 3128101 ccgtcaccgg cgttctgttc atcatttgct ctacccgctc gatatccggt cttgactgaa 3128161 tcaggcgctc tttcccgata aattcttcaa caaactcatt tgccgggttt cgaagaatct 3128221 catcaggtgt gccgacttga acgatttctc ccgcttttaa tatcacaatc ctgtcagcaa 3128281 gcttaatcgc ttcatccata tcgtgggtta caaacacaat cgttttgttt aaggttctct 3128341 gcagtttttt gaattcttcc tgaagggaat cacgcgtaat cggatcaagc gctccgaacg 3128401 gttcatccat taaaatgaga gggggttccg ctgccagggc gcgcagcacg ccgattctct 3128461 gctgctgtcc gccgctgagc tcatgcggat aacggtctaa atactctggg cccatatcca 3128521 caagctttaa cagctcgcgc gcccgttctt tccgtttttc ctcaggccat ttcagcagct 3128581 ttggtacgag tgagatgttc tgctggatgg tcatatgggg gaacaaacca atctgctgta 3128641 tcacatagcc gatttttctc ctcagctcaa ccgggtcctg ttccataata ttttctccgt 3128701 cgataaagat ccttccagac gatggttcta tcagtctgtt gatcatcttc atcgtcgtcg 3128761 tttttccgca gccgctcggg ccgataaaac agataaattc accttttgca atatctaaat 3128821 caatgctgtt cacagctttt ttgccgcctt tatatacttt tgacacttgt tccaatttca 3128881 gcaatccgtg cacctccgca ggtttccttt aaattttctg aaaagtataa tccttattat 3128941 agtttgaact ttgtaaaata aaaagtttac aatgtgttga aattatatgt tatttataga 3129001 ttatttattg ttatgaccga gacggaaagg gtgttcttac aattactccg gatacctccc 3129061 acttcctctg cattcagcta ttttcaacac caggaagaaa tatgatatat tgacaccatc 3129121 aattgccatt tgaagggatg atcagctgtg aaaaaaaccg ctctcgacat cattgaacat 3129181 gctgaagagc atctcattga gaagattgcc gaaaatatgc atacgtttgg aatgccttca 3129241 actgtcggac gtgtgctcgg aattatttat atgaatcgaa aaccaatgac cttaagcgag 3129301 ctctctgagg caacgggcat gagcaaaaca cggatgagcc aggttgtccg ggaaatgatc 3129361 gatgccaata tcgccgaaaa ggtgtttgaa aaaggcgtac gaaaagacct ttatgacgtc 3129421 gagcaggatt attatcaaac cttcatttct ttatttgcgg cgaattggac aaaggtcgtg 3129481 agcaaaaaca aagtgctgta taaaaaatta aaccgggagc tgagtgatct tttacaaagg 3129541 gacgggctta ccccggaagc ggaagagaaa gtcaatcagc tgctgaatga attaaaagaa 3129601 tggcttcatt actatgattg gctgagcagg ttgattgaat tttttgagag tgaggaagtc 3129661 tttcggtatg tgccgaaaac aaaagaatgc agctctctaa aataagagag ctgctttttg 3129721 catcatgaag ttaagaccgg aaacatgcct ttcagcccgg caccaatcat cccgaccgca 3129781 accacggcta agattaatcc catcagtctg gtaatcacat tcatctcggt ttttccgagt 3129841 ttgctgctga taaaagcaga atagtggaaa aagagaaagg tcagggcaat aacggcggct 3129901 atgccgatca tgacagccgc ataatgacca atgccgctat gtccggcgga aaggctcatc 3129961 actgttgcaa tcgttccggg cccagcaatg atcggaatgg ataaaggtgt gactgatata 3130021 tccgcttttt ccttgctttc cttatgttca tcatggtgaa gagattgcac gtgcgattct 3130081 ttcgcattca atagattata ggcaatgccg aaaatgaata tgccgcccgc cactcggagc 3130141 gcgtgaatgt tgatatcaaa cagtttaaag ataagatgac cgaaaaccaa aaaagctgcg 3130201 agaataaaaa aggataaaat agctgccttc cgggcaatcg cttttctttc cgctgcagta 3130261 tagccttctg tcagcgtcag aaatatcggt acgtttccga tcggattcga tactgcgaat 3130321 aaagaaatga agacgtgaac gataaatgag aacatcatat acctccttgt tgatagtctc 3130381 tgcacaggaa atagaatgat tctccaccct tttacccgga ggcgatttcc cggtaaacct 3130441 ttatagcctg tcagaaacgc gccatgctac aatgaagtga caaattgaat aggaaggacg 3130501 tatacagatg ttcaaaaaaa ttgcggcaga tgccttgggc ttatctgata tcggaaaaat 3130561 tatcgaacct caggactatg acaaaacaga cgcagatgac tatgtcatgc atgaagataa 3130621 tgagaaaatt tatttcttga ttaaaacaaa agcagacgag tattgcttta cgaacctggc 3130681 cctgatccat gtggacggcg aacgcgccac ttcctcaaaa cgaacgttga aacgctatcc 3130741 ttattcgcaa tataaaatct ctgacgtttt tcttgaaact gccggaaaag tggatttgga 3130801 tgttgaaatt aagttcaagc tgggcggtga acaattcgac attgatgtcc acaaagacca 3130861 gattgaaaag ttaaaagacc tttataaagc actgcttcgc atcgctgaaa caacctatga 3130921 aaatgacatt ttaatcaatc aagcggagca aagcttagat aaagcagtga cgattcttca 3130981 ccatacccgc cctgagcacg tcaatattga aacgcaatac aaagagctga ccgaattcgg 3131041 attcacttgg ctgacatccg ttcgctcgca gtatcatatt aaggattttg gggatgtatt 3131101 tgagaaatat attaataact agataaaaaa agacacagct gctatcgtgc tcgtgtcttt 3131161 ttttgtatga atattgatta ctttacaact tttttctttt ataataaaac tattagtcta 3131221 ttttccctat attacagata aaggagttat tttatgtatt gtcctcaatg cggccatcaa 3131281 acagatggcg gaaatttttg tgagaaatgc ggatcaccgc tccccggtca atcaggccac 3131341 cagcatgcag ctcaaactgg agccgctgca aagcaagcag caaaacagtt cggttcattt 3131401 gtcttatccg tcctgaaacg cccttatcag gaatgtaaag caacaggcgg agaacagctg 3131461 atcagcgcaa tcattacgat ggttcttttc agtttgctga cccctttgat gttttatatt 3131521 cttttttcag acggtcccgg aagcgtaagc tttacagcaa tcttcttaga gccaaccatt 3131581 tattttattt tatttctatt tggcctgcat gcatgcatct ttttcgccct gaaaatcgcg 3131641 ggaaaccaag tgtctttcaa ggattcattc tcaagattcg gagcatttct tattcctttt 3131701 acggctattt tgattcttgc ccttttcttc tttttattac atacagacat ttgctttacc 3131761 atattagccg ttggtttaat cggtgcattc ttcgccattc ctcctgcgat gctgagcagt 3131821 taccagcatt catataaagg gaaggttgat ttcatttact caacgattgt gatttatctg 3131881 atcatctgcg ttacatttca gcttattatc gaacactatg tcaaagaaat tttccgttat 3131941 atgctctttt aaaaacaacc ccatcacctg ctggtgatgg ggttgtttta ttgaatagac 3132001 gttaagtaaa ttcttccgtt cttcactacg ccggtgtagg tccagttata tgttctgagc 3132061 tttggactgc cgcctgattt tgtgatatag aattcttcat acgtcttaat cgtgatagcc 3132121 gacccatttt ggctccagct tttcacttca tagttattaa agtcttctgt tgtcccctct 3132181 ttatttaatt tcgacacgag atgctgctgg tcggaataaa gggaactgcc tttttcaagg 3132241 ctgtcttcca tcagtgagaa attattttga ttcacggcat ctgcctgact ttgcagataa 3132301 ctgcccataa ataatgtcac ttgttcatct gtaacatcgc cgcttgcaga gctttcactg 3132361 cctttgtttt tcgagccagc ccaggcggaa gtgtatgtct ctggtttatc atttttgatt 3132421 ttctttatat ttgtgcctgc agattcgaat gttgattctg catcttcgaa aatccacttt 3132481 ttctgttttt tatcatatga aagaagatat tcataactcg gactgtcgtc agtcatttca 3132541 gactttgtat agtcgttata cgaagaagac tggtgaagtt cttttcctgt taccgatacc 3132601 tgccacgttc cgtcgttttt ctgagagagg gcaaatgtgt ccaggtcaaa atcagtttcc 3132661 aagtatctat cttttaagta tgaatccgcg cttttcatag aatcgacggt gtccttcgtc 3132721 tccgccttcc aattggcact tgcctctgtc atctgggctg tattcccatc agatagagct 3132781 ttggagtatt gttttgttgt tttgacaatt gtgttcataa tctgttcctg tgtatcttga 3132841 tcaggaatta acgttaactc catttcttta tcatcgatcg gaacgccggc agtttttgtt 3132901 tttccccacg gaaattctgc ctcgactgaa gctgtcattg atccatctgt cagcagcgga 3132961 ccatatgtta cggatttgaa cggatcttta tgaattgatt taccgttaat cagcaaatct 3133021 cccttcccgc tcttgatgtc attcgctaag ctgaatgtca catcgtctgc ttccaatgag 3133081 agatcaacac gaaagctgct atcgccaatc gcctgaatgt cttccttttt cacaaggtca 3133141 acgacatcgt ttttcagttt ggctgagact gtatattcgc cgggaatgta cggaccaagg 3133201 gtttgtgctt gatctgcttt ctttacagat ccggcttcct ctttattgac atatagatcg 3133261 gtatttttat aattgctgct cacttcaaaa taaacaggtg ctacctttaa gtcataatgg 3133321 tcaaatacca gcaggctttt cccgtctttt tccgcatata cgatatcctt ctgggctgtt 3133381 tcatcacgca gcgatgcaaa aagttcatct tttttgtctg gatgatcctt caaatatgta 3133441 agaaacggtt ttacattatt tttagtgagt ttaagattgt catttaccgg tgtaagcaga 3133501 gtcgcgattt ggtcctgatc cccatcattt acggcctgtt caaacttgtc tactaaccta 3133561 tcctttgaag taaaatacgc tccggtttta tatgcggcga ataatataac gcacgccgcg 3133621 gcaatgctgc tccataaaat gatggttttc ttagggatcg gttttcgcgg agcctgcctc 3133681 gtttctgcag tgctagctgt ttcttgattt gcctgtttgc tgccccctcc gatcggggtg 3133741 ccgcattgtt tacaaaactt ggctccttca ttattctggg agccgcaatt cttacaaaat 3133801 aacatgactt tcctcctatt ctactaattt gataacattt actgcttttc atattttata 3133861 ataaaacaga atgaaattgg gaacgaatga aaaaattaaa tgtctatcag actaaaaagg 3133921 tggaatgaat atgcaaaagc tcaggattga attaggagaa gaaacaaatg acgaattata 3133981 tgatctattg ctgctcgccg atccatcgaa agacattgta gatgaatatc ttgagagggg 3134041 agaatgttac acagcttggg ccggtgatga gcttgcaggg gtttatgtat tgctaaaaac 3134101 aaggccgcaa acagttgaaa ttgtaaatat tgcggtaaaa gaatctcttc agaagaaagg 3134161 ctttggcaaa cagcttgtac ttgacgccat cgaaaaagcg aagaagctgg gggcggacac 3134221 gattgaaatc ggaacgggga attcgagcat tcatcagctt tccctctatc aaaaatgcgg 3134281 attccgcatt caggcgatcg accacgattt ctttctcaga cattatgatg aggacatttt 3134341 tgaaaacggg attcaatgcc gcgatatggt aaggctttat ttggatctct gaaagcataa 3134401 aaaagccgcc gagagaaaat cccggcggtc tttttattac ttgtttaagt tgtagaaaga 3134461 gttgataccg tggtattgag cagtttcagc caactgatct tcgatgcgaa gaagctggtt 3134521 gtatttcgca acacggtccg tacgagacgg agcacctgtt ttgatttgtc ctgcgtttgt 3134581 tgccacagcg atgtcagcga ttgtgctgtc ttcagtttca ccagaacggt gagagataac 3134641 agctgtgtag cctgcgcgtt tcgccatttc gatcgcatcg aatgtttcag tcaatgtacc 3134701 gatttggttt actttgatca ggatagagtt gcctacgccg tttttaatac cttcagaaag 3134761 ttttttcgtg tttgtaacga agaggtcgtc accaacaagc tgaacttttt tgccaagacg 3134821 ctcagtaaga agcttgtggc cttcccagtc gttttcgtca agtccgtctt cgatcgagat 3134881 gattgggtat ttagaaacaa gctcttcata ccagtcaacc atttcagcag atgttttcac 3134941 aacgccttcg ccagacagat ggtatttgcc gtcttctttg ttgtagaact cagaagatgc 3135001 agcatccata gcaagtttaa cttcttcgcc aggtttgaag ccggcttttt cgattgcttc 3135061 aacgattgtt tgaagcgctt cttcgttaga accaaggttt ggagcgaatc cgccttcgtc 3135121 acctacagca gtgtttaagc cttttgcgct taatactgat ttcaggctgt ggaagatttg 3135181 agcgcccatg cgaagtgctt cacggaagtt aggagcacct acaggcatga tcatgaattc 3135241 ttgaatatcc acgttgttat cagcatgctc tccgccgttt acgatgttca tcatcggtac 3135301 aggaagcgtt tttgagttga atcctccaag gtattggtaa agaggaatct gtaagaaatc 3135361 agcagcagca cgcgcacaag ccatagatac gccaaggatt gcgttcgcac caagtttgcc 3135421 tttgttttca gtaccgtcaa gctcgattaa aagctgatcg attgcgtttt gttcagttac 3135481 atcaaagcca agaagctctg gagcaatgat ttcgtttacg ttgttaacag ctgttaacac 3135541 gccttttcca aggtaacggt ctttgtcgcc gtcacgaagc tcaaccgctt cgtattcacc 3135601 tgtagaagct ccgcttggca ctaatgcgcg gccgaaagct cctgtttctg tatatacttc 3135661 aacttcaact gttgggttgc cgcgggagtc taatacttcg cgtgcataaa catcaacaat 3135721 gtatggcatg agttttgtct ctccttttga ttttcaaatt atttttgaat taaagatgtt 3135781 cctgtcattt ctttcggttt ttcaacacca agaaggtcta ataacgttgg tgcaaggtcg 3135841 cctaggattc cgccttcacg cagcgtaatg ccttctttcg ttacaatcac agggactggg 3135901 tttgttgtat gcgcagtgtg cggttcgcct gattctgtaa tcagaatgtc agcattaccg 3135961 tgatcagcgg taatgatagc gtgtccgcct ttagcaagga tcgcgtcaac gacttcgccc 3136021 aagcattcgt ccactgcttc aattgcttta attgttggtt caaccattcc ggagtggccg 3136081 accatatcag ggtttgcgaa gttaagaatg atcgcgtcat gcttgtcagc ttcaatttct 3136141 ttgacaagcg cgtctttcac ttcatacgca ctcatctcag gcttcaagtc atacgttgca 3136201 actttaggcg agttgatgag aatacgctct tcacccggga attcagcttc acggccgccg 3136261 ctcataaaga acgtgacgtg cggatacttt tcagtttctg caattcgaag ctgttttaac 3136321 ccgtgctgag ataatacttc tccgactgtg ttatcaagat ttatcggttt aaacgctaca 3136381 tagccgtcaa ctgtttcact gaagtgagtc aggcagacga aatacaggtt ctttggataa 3136441 ttctcgccgc ggtcgaagtc acggaagtct ttgtttgtga acgtgttgga aatctggatg 3136501 gcgcggtccg gtctgaaatt atagaaaatc acagaatcgc cgtcttggat tttcgcaaca 3136561 ggctcaccgt tttcttttgt gatgacagat ggaatcacga attcatcgta gataccattt 3136621 gcatatgaat catcaacaac atccagggcg ctgcggtaag atgggccttc gccgtacgcc 3136681 attgcgcggt acgctttttc tacacggtcc cagcgtttgt cgcggtccat agagtagtaa 3136741 cgtccggaaa tgctggcgat ttcacctaca ccgatttcct tgatttgatc gttcaactgg 3136801 ttgatgtacg ttttcgctgt ctgcggacct acatcacggc cgtcaaggaa gccatggata 3136861 taaacctttg tcagcccttc ttttttcgca agctttaaca gtgcgaataa atgattgata 3136921 tggctgtgca cgcctccgtc agataaaaga ccgaacaggt gcaaggcttt gttgttttct 3136981 ttcgcgttgc tgatcgcgtc aaggaatgtt tgattgcgtt cgaactctcc ttcacgaatg 3137041 gcaacattta cgcgtgttaa gctttggtac acaatacgtc ccgcaccgat atttaagtga 3137101 cctacttcgg agttccccat ttgcccttca ggaagaccta cagcctcgcc tgaagcagtc 3137161 aaagtttgat gaggatactg gttccaatag cggtcaaaat tcggtttttt cgctaaagcg 3137221 actgcgttcc ctactgtttc gttacgtaat ccgaacccat caagaatgat gagtgcagct 3137281 ggttttttac tcatattgac cttcctccaa taattgaacg aatgactgtg gctcaaggct 3137341 cgcgccgccg accaaagcac cgtcaatatc ggactctgcc atatattctt taatgtttgc 3137401 aggctttacg cttccgccat attggatgcg aagcttgtct gcagcttctt ggctgaagct 3137461 ttcagcgacg gttttacgga tatgcgcaca cacgtcattc gcatctttcg ctgtagaaga 3137521 tttgcctgtt ccgattgccc agattggctc atacgcaata acagaagcag caacttgttc 3137581 ttcagaaaga ccagcaaggc cttttttcac ttggtcagca acaagatcat ttgttttgcc 3137641 ggcttcacgc tcttcaagcg tttcacctac acagatgatc ggcacaatgc cgtgtttgaa 3137701 agctgcgtgt gcttttttgt taactgtttc atcagtttca gcgaacattt cacggcgctc 3137761 agagtggccg atgacgcagt agtcaacgcc aaggtctttc agagcaaccg ggctgatttc 3137821 gcctgtgaac gcgccgcttt cttcgaagtg catgttttga gcgccgactt ttaggtcagt 3137881 gcctttcaca gcagaagcaa gcttttctaa gaaaagcgct ggcgcgcaaa caacagcttc 3137941 agctttgtct gctgctggaa tggaagattt cacttcttca acgaagctga cagcttcgcc 3138001 gagtgttttg ttcattttcc agttaccggc gataattggt tttctcatct gttccacttc 3138061 cttatagcag ttttgagatt atttatcgtt cagtgcagct acccctggaa gctctttgcc 3138121 ttccataaac tcaagggatg cgccgccgcc tgttgagatg tggctcattt tgtcagcaag 3138181 gccgaatttt tcaaccgctg ccgcagagtc tcctccgccg atgacagagt atgtatcttt 3138241 cgcctctgcc aatgcttccg caaccgcttt tgttccttga gcgaacaagt cgatttcgaa 3138301 tacgcccatt ggtccgttcc acacgacaag tttgctgttt ttgatgacgt cagcatacgt 3138361 ttcgcgtgtt ttcgtaccaa tgtcgattgc ttctaaatca ctagggattt cagagatcgg 3138421 cacaattttc acgtttgcat cgttagagaa atcatctgca acgagtacat cttcaggcat 3138481 gtagaagtta acgccttttt ctttagcgcg gtccataaat gatttcgcaa gctcgatttt 3138541 atcctcttca agaagagatt tcccgacttc atagccaagc gcttttacga aagtataagc 3138601 aagacctccg ccgatgatca ggttgtctac tttatcaaga agactttcga ttacaccgat 3138661 tttgtctttt actttcgctc cgccgatgat cgctgtgaac gggcggtcag gattggaaac 3138721 cgcttttcca agtacatcaa gctctttttc cattaagaaa cctgcaactg ctggcagatg 3138781 ctcggcaatt ccagctgtag atgcgtgagc acggtgggca gcaccgaatg cgtcatttac 3138841 atatacatct gcaagctcag caaatgcttt tgcaagctca ggatcatttt tctcttcacc 3138901 aggatagaaa cgtacgtttt ccaatacaag aacgtctccg tccttcatct cagaaatttg 3138961 tgcttttaca gcatcgccgt atgcttcatc cgcttttttc acttctttgc caagcagttc 3139021 gccgagacgt gcagcgacag gagttaaacg aagctcctca accacttcgc ctttcgggcg 3139081 gcctaagtgg ctcgcaagaa ggacttttgc gccttggtct gcaaggtgtt tgattgttgg 3139141 aagcgcagca cggatacgtg tatcgtctgt tacttccccg tctttcattg gaacgttaaa 3139201 gtcaacgcgg cagaatacaa ctttgccttt tacgtcgatg tctttgagag tttttttatt 3139261 catgcctagg agatcctcct tcaaaatggt ttgcatacag cacgaaaaac gtgaaaccgt 3139321 ctgttcaagc gataactccg ctagggcaga tcgcagtctt tttcggcaca gggcagttcg 3139381 tctaaaagcc agggcagcgg ccttaggcga aagcgccggc aaagctgctt aaaacgcggt 3139441 cgtttctcta tcacagagcg ttttctgaaa gccggtcttc atggaaaaag ggaaagggag 3139501 tccgtcccct tcccttgtcc gctttcatta tagcgcttct attcgaaaga accaagtcag 3139561 gtcctttttc agctataaat taaagacctt tttttgcgat gtaagctgca aggtcaacaa 3139621 cgcggttaga gtagccgctt tcgttatcgt accaagagat tacttttacc atgctgcctt 3139681 ccataaccat tgtagaaaga gcatcgattg tagaagagtt tttgtttccg ttgtagtcgc 3139741 cagaaactaa tggctcttcg ctgtagccaa ggattccttt aaggtcgcct tcagccgctt 3139801 ctttaagagc tgcgtttact tcttcagctg ttacttcttg gttcagttca gcaaccaagt 3139861 caactagaga aacgtttgga gttggaacac gcattgctcc accgttcagt ttgcctttta 3139921 gttcaggaag aactagagaa actgctttag cagcaccagt tgatgttggg atgatgtttt 3139981 cagctgctgc acgcgcacga cggtagtctt tgtgcggaag atcaaggatt tgctgatcgt 3140041 ttgtgtaaga gtgaacagtt gtcatcatac cgcgtttgat gccgaattta tcgttaagta 3140101 cttttgcaaa cggcgcaagg cagtttgttg tgcaagatgc gttagagata acatcgtggt 3140161 tagccgcatc gtatttatct tcgttaacac ccataacgat tgtgatatct tcttcgttag 3140221 caggagcaga gatgattact tttttcgcgc cagcttctaa gtgtttcgca gcgtctgcgc 3140281 gttttgtgaa gaaaccagta gattcaacta cgatttcaac gccttgtttg ccccagctaa 3140341 gtttagcagg atcgcgttct gcagaaactt caattgtttt gccgttaaca acaaggttgt 3140401 taccgtcaac tgaaacttca gcgtctaatt ttccgtgtac agaatcatat tgtaaaaggt 3140461 gagccagcat gttagcatct gttaaatcgt taaccgctac tacctcaact tcaggattgt 3140521 ttaatgctgc gcggaatacg ttacgtccaa tacgaccaaa accgttaata ccgactttta 3140581 ctgccatgat tgtttcctcc tttaaataag tgagagatat ttatattgag ggattattca 3140641 tcccttaata acttctttgc ggctccttcg tctgtgacga gaaccgtgtt gcgtggcttt 3140701 ttaaagtaag cctcgatcgc ttcggctttt gatgatccgc ccgctaccgc aataatatcg 3140761 gggatggcgt ctatgtcatc cagctgcatt ccgacagaat gcactttgtg aaccacttcg 3140821 ccgtccgcgt taaaatagta gccgaacgct tccgtcaccg cgtcgttatc atctattttc 3140881 tttaaatctt ctaaaggcgt gtttctgcgc tgagccatag ttttagcttc gccgattccg 3140941 tgaaccagca tactcgctga tttaatggtg ttcagcacct ctttgacaga aggctcttca 3141001 ataatagatg aataggcgcc ttgtgacagc tgtcccggaa caaacaaaag ccggtaagtg 3141061 cctgaagcct tctccgccat atgcgcgcat atggtgttcg cctggttttt cacgtcttcg 3141121 cctaaaccgc ctcttgcagg cacaaacaaa agctcgcggt ttttagaatc cggcgtcatc 3141181 atttcggcga cagcttcaat tgtcgtaccg ccagttacag cgacgatatt tttgcctgaa 3141241 aatctttttt tcatacatgc gacagccgct cttcccattt cttttttgac ccatggggat 3141301 tgatcgctgt ctccggatac gataatggca tcctttagat ttaaacgttc ttttaatgtc 3141361 ttttccaaaa gagtcaaacc taaaacatct ttcatcgtat cttccaaaac agaaagcagt 3141421 tcatagccct cttctgtcaa tgtcatgccg tttgtcttaa tatcgaccag gttctgttcc 3141481 tttaaaaact gaacctcgcc cctcagcaca cgctcgctga ttccgagact ggcagacagg 3141541 cttcttcgcc cgatgggttc tgtcagcctg atatactgca agatttcaaa cctcttttgc 3141601 ataacgagca gaagatcagg caataatttt ttttgagctt gtattaactg gttcatgact 3141661 caaacgttcc ttcctttttt gctggacatt atatgtcccg ctatgacaaa aaacgtcccg 3141721 tcatagccaa aaaaaatcat ttctgctttc tttaattatt ttaacagggt ggaattgttt 3141781 attcaactgt taagagccaa ttcatcgaca atattcgcag agttttcatg ccgcgtcgtt 3141841 ttatccagca atattttatc ctatatatct ttatcttata cagaaagcgc caaatggtgc 3141901 atcccaatat aaacagccct tcccgtagaa agggctgttt cattaaagcg ttttcatttt 3141961 atccaaagct tttcaatttc ctcgagcgat ttgttcttcg tttctggaca gatcgtaacg 3142021 acaaacagga aacaaaggat gttaatcacc gcaaagatcc aaaatgtata ggcgagcccg 3142081 aaagaatcga tcatcattgg cacaaactgt ccgatcgccc agtttgctcc ccataaaaag 3142141 atggtcgcaa tgcccgcggc ccgcgcacgc agatggttcg ggaagatttc agaaatcata 3142201 atccatgtga tcggtccgac cgagacacag aaagcagcga caaaacctaa tataaggacg 3142261 atcatcatga tcccgcttgt taactcaaaa taaaacgacg tcccgattaa aatcataaaa 3142321 atagccataa aagcagaacc gatggacatc agtttttttc gtccgacttt atcaatcagc 3142381 aacaccgcaa taacggtaaa aataacttct acaaccccga cgatacaagt cgtcacaaat 3142441 ccggcgtttt gcccgaatcc catcatttta aagatttccg gcccgtagta agtaatcgcg 3142501 ttcatgccga tgacttggtt aaacagcgcc agcaggattc caatgacaag cgcctttctg 3142561 agacccggct taaacagctg ggagagcgac cccatttgtt ctatttttaa agagttctca 3142621 atgttcttta attcttcttt tgcaacagtt tctccattaa tacgtgtcag gatctttaaa 3142681 gcttcatttg ttttgcccgc tttcgccagc catctcggac tttccgggac gacgagcagg 3142741 acaaggaaaa aaatgacgga tggcaccatt ccataagcaa gcatccatct ccagccggtg 3142801 tgcacgcccc attcgtatgt tccggaccgc tgcacagcta gattaataaa gtatgttgcg 3142861 gaaataccca gtatcgtaaa gagctgatat aacgaagata aacttccgcg tatagcgggc 3142921 ggtgccgctt ctgtaatata cgtaacagag agcgatgagc ccatcccgat tcccagcccc 3142981 ccgataatcc ttgcaatgat taaggtggac acgtcttgag aaagcgctga aacgattgct 3143041 gatatcgcaa ataacaaagc ggctgtcatt aaaatttttc tccggccgaa tctgtcactt 3143101 aaaaatccgg atatcccgac gcccacaact cctccaatca taatgcttga aatgacaagt 3143161 ccctccataa acggactcag gctgtataaa tctttcagaa aaccgatggc gccagaaatc 3143221 actgccgtgt catagccata caataagccg ccaagccccg ccgcacatga gatcaaaatg 3143281 acaaatccca ttgaatggct tcttgttaca ggaacatttg gttctaattg agttggagta 3143341 ttcttcattt ccctgccctc ccgaatgttg agtaaagcgt tttcatttaa accttcaatt 3143401 gtacgtactt atattaaaat ttaacgaaaa ttacatttaa ttagtacgta caaatataga 3143461 ataatcttgt ttgcattttc tgtcaatgtt ttcttacaaa gaacgctgtg atatactgaa 3143521 atttgtccgt atacattttg gaggaatgga tatgttacca aaatacgcgc aagtaaaaga 3143581 agaaatcagt tcttggatta atcaaggcaa aatactgccc gatcaaaaaa tccctaccga 3143641 aaacgaatta atgcagcaat tcggcgtcag ccggcatacc atccgcaaag cgatcggaga 3143701 cctcgtatca caaggtctgc tgtacagcgt gcaaggcgga ggcacctttg tcgcttcacg 3143761 ctctgctaag tcagcgctgc attccaataa aacgatcggt gttttgacaa cttacatatc 3143821 agactatatt ttcccgagca tcatcagagg aatcgagtcc tatttaagcg agcaggggta 3143881 ttctatgctt ttgacaagca caaacaacaa cccggacaat gaaagaagag gcttagaaaa 3143941 cctgctgtcc cagcatattg acggactcat cgtagaaccg acaaaaagcg cccttcaaac 3144001 cccaaacatc ggctattatc tgaacttgga gaaaaacggc attccttttg cgatgattaa 3144061 cgcgtcatat gccgagcttg ccgcgccaag ttttaccttg gatgatgtga aaggcgggat 3144121 gatggcggcg gagcatttgc tttctctcgg ccacacgcat atgatgggta tttttaaagc 3144181 tgatgacaca caaggcgtga aacggatgaa cggatttata caggcgcacc gggagcgtga 3144241 gttgtttcct tctccggata tgatcgtgac atttacaacg gaagaaaaag aatcaaaact 3144301 tctggagaaa gtaaaagcca cactggagaa aaacagcaag cacatgccga cagccattct 3144361 ttgttataac gatgaaattg cgctgaaggt gattgatatg ctgagggaga tggatcttaa 3144421 agtgccggag gatatgtcta ttgtcgggta cgatgattca catttcgccc aaatctcaga 3144481 agtgaaacta acctctgtca aacatccgaa atcagtgctt ggaaaagcag ccgccaaata 3144541 tgtcattgac tgcttagagc ataaaaagcc gaagcaagag gatgtcatat ttgagcctga 3144601 gttgatcatt cgccagtccg cacgaaaact gaatgaataa aaaaagcaat gtatgggtct 3144661 ccccgctaca ttgctttttt tatagctgtt atctgttttt ccaaacgtca gcgatgattt 3144721 caaacgaacg cattctgtct gcgtgttcaa aggtttctga gttaaccata atttcgtcag 3144781 cctgtgtcgt tttgacgaaa tcttcaagct tcgccttcac ttcttccgga cctccgacaa 3144841 tcgtggagct cagctgctca ttgaccatcg ctttttcata cgggctccag atttggtcca 3144901 tatcctcaac aggcggttta agctggttag gcgtaccgcg gacaagatca agaaaccttt 3144961 gataatggga agtcgcaagg tgctgcgctt tctcgtttgt atctgccgcg ataatggtga 3145021 caccgaccat cgcatacggt tcgtcgagca cgtctgacgg cgtgaaggaa ttgcggtaca 3145081 gctccaaagc gggaaccgta ttcgccggtg agaaatgggc cgcgaacgca aacggaagac 3145141 caagttcgcc agccagacgg gcgctgaagc cgcttgagcc cagcagccaa atcggcacat 3145201 ctatgccctc tccgggaatg gcgcgaactt gattgcgcac atttcctgac ggtttaaaat 3145261 aattgcgcag ttcctctaat tgttctggaa aatcctcccc gctgttgatg tttctgcgga 3145321 gcgctctggc tgtcaattgg tctgttcccg gcgcacgtcc aagccccaga tcaatccgcc 3145381 cgggatacag tgtttccagt gtgccgaatt gttcagcaat gactaatgaa gagtggttgg 3145441 ggagcataat gccgccggaa ccgacgcgga ttttcttcgt gcctccggca atatggccaa 3145501 tcaaaactgc ggtggcagag cttgcaacac cttctatatt atgatgttca gcaagccagt 3145561 aacggtgata gccccattcc tctgcccggc gcgccaagtc catgctgttt cggaatgatt 3145621 ctgcaatcgt tcctccctga acaaccggag ataaattcaa gacagaaagc aaggtatctt 3145681 tgcgttggtt gttagacata ttgttctcct ttgcaaatgt gttatcagta aacagcccaa 3145741 agctgtcagg tcatgattga aagaacttct atcacaccat aacacaactg cattcaggaa 3145801 taaaagaatt tgattcgatg aaattcgaac aatataaaac gaacggtttg gaacattatt 3145861 ctgctccaaa caactcctta gccatctcaa taaagagctt agccgccaga gaagcctcct 3145921 ttagcgacgg aacagcaagc tgcacatcac ggtatacctg cgggtccaat tccctggtca 3145981 ccacatgctc tggcagcggc atccccgaca tggacatttc tgataaaatg gccaggccca 3146041 ggccttctct gatcatactg atcgaggtgt tgatgttata gaccgtgaaa gctgggtgca 3146101 gcgtagcacc cgcctgcctg aacatatcga taaatggtga ttcatagccg ccgtcacaga 3146161 cgatcatcgg ttcatggtca agatctttca gcgtaatggc tgaatgactg gcaagcgggt 3146221 gatcgtccct gagcacgaca gccattttgt cttttttcaa atgaatgtac tccatctcct 3146281 ctgttggata cagaagaatc ccaacatcta tcatccgcgt atgaagccac tccttgactt 3146341 catttacagt tccctcgtgc agcacgagct caagtttcgg atatttttgt ttaaattcac 3146401 tgatcagctt cggcataaaa taagccgagg cagttgagaa tgtgccgata tggatcgttc 3146461 ccagttcaag ccctttttcc gctgctgcta cctgctcaac tttttcaatg ccttttaaga 3146521 cttctctgat gtgtactaag atctgttttc ccgtatccgt cagcatcagg ccattgcggc 3146581 ggtcacgaat gatcagcttt acatcaagct cagcttcgat cgcagaaatc gcatggctga 3146641 cagccggctg tgtcatgttc agcgcctgac ccgcttttgt aaagcttccc gtttcagcta 3146701 ttttcacaaa aacctttaat tgagtaatgg tcataacaat ttacttatgc tccttataaa 3146761 aaagattcat tttatttatc ttatgttcta ccgtatcata tgatggaaaa gttctacaag 3146821 gagtgaatga acaatgaagc agctcccaaa aacgcggaca gctctcctgc tcgcatttct 3146881 cgtcatcatg tggggcgtca attggccgct gtccaaagcc gcgctcgcct attctccgcc 3146941 attattgttc gcgggcatcc gaacgctgat cggcgggctt ttattagtca tagtcgcact 3147001 gccgcgtatt cataaattac gcttaaaaga aacgtggccg atttatcttg tttctgctct 3147061 tttaaatatt acattattct acggcctgca aacgatcggg ctgaattatc ttccggccgg 3147121 cctgttttct gcaatcgtct tcttccagcc tgttctgatg ggtgtatttt cttggctgtg 3147181 gctcggcgaa tccatgtttg taatgaaagt gattggcctc atcctcggtt ttgcgggagt 3147241 agccgtcatt agtgctgcgg gctttggcgg gcatatttct gtcattgggg ttctgctggc 3147301 tctcggctcc gcagtcagct gggcgctcgg gacagtatat atgaaaaaaa caggcagccg 3147361 cgtcgattcc atctggatgg tcgctctgca gctgacgatc ggaagcgtgt ttctgcttat 3147421 ctccggcttt tggacagaaa gcttttcggc gatccaatgg acagctccgt ttattacgag 3147481 cctgctgttc atctccgtat tcgttatcgc actcggctgg cttgtctttt ttacgcttgt 3147541 cggttcagga gaagcaagca aggtcgcatc ttatactttt ttgattccgc tcatatcaat 3147601 cgtggccagc tccattttcc tgcatgaacc gctcaccctt agcctcttgg cagggctgct 3147661 gctgattgtc acgagcatct gtctcgtgaa tacaaaatca aaagcgcaga aagctgcggc 3147721 gattggtata aacgagaaag ctgcacaata ataaaaaccc tcttgccgga tgcggcaaga 3147781 gggtttctta tttactgatg cttgcgtcct ttgaccaaat atgcaactgt aatcaaaagg 3147841 tagatcgccg cagtaatgcc ggtaatgaca attgatgttg tcatgatgac cccgatcaga 3147901 atggcgagta atgccacaat cgcaaaccat gtcgtgtacg ggaaccattt tacataatag 3147961 gccggtgttt ccgtttgctg ttttctcgat tttaaatgag cgaatccgat gatcagccaa 3148021 atgaataaaa cggtatatcc caatgatccc attaaataat taaatgtttg gcttcctgcg 3148081 aacagagaaa tcaatacgcc aatatagaga gaagaagtgc acatcagaat cgcaaacatc 3148141 ggtacgtttt tcgatgaaag cttcgagaag acctttggaa gccttccgtc acttgcctgt 3148201 gtatacaaaa tgcgtgatga tccgtataaa cctgaattca tagaagaaat gatcgccagc 3148261 aggatgactg cattcatgat atgatccgcg cccggaatgc ctaccatttt aaagaccatc 3148321 acgaaaggac tttccggaac ggaattgact tggttccatg gaatcaggct gacgatgatg 3148381 aaaaacggca gcaggtaaaa cgcgacaatc cgtgtcagtg tgctgcggac agctttcggg 3148441 acaacctttt ccggattttt tgtctctgca agcgttacac cgataatttc tgtaccgccg 3148501 taagagtaga tgacgacaag catcgccgtg atcagccctg tgccgccgtg cgggaaaaat 3148561 ccgccgtggt ctgtcaggtt ggaaaatccg gatgctgtat gatcaccgaa tgatacaaat 3148621 aagagcagca atcccagaat aataaagata ataataacgg taatcttgat cattgccagc 3148681 caatattcag tttcggcgaa gattttaaca gaaagcaagt ttacaatcgt gacgataaga 3148741 gaaattccta atgccaacac ccagatcggg cagcccggca gccaatattg aatgaaaatc 3148801 gcagctacaa cagcttcagc cgcaatgtta agcacccaca ttttccagta gatccagtcc 3148861 aaaaagtaag cagcgtaatt tcccaatacc tgctggacaa gatcacggaa ggttctggcg 3148921 ttacggtttc gaacagccat ttccgccagc ccctgcataa taaacagcaa aataatcccg 3148981 ccgagcaggt atgcgataat gacagatggc cctgccacat cgatcgctga gctgctcccc 3149041 ttaaataaac ctgcgccgat tgctccgccc agcgccatca tcataatatg gcgggacgtc 3149101 atcgtgcgtt ttaacgtttg attgtcgttt ttcatcctct tctacctctc cttctcgttt 3149161 tcaaaaacaa aaaagcccgc cgtctcctac ctaatctaat agataaagag acgacgagcc 3149221 ttcggctgac cgcggtacca ctcttgttga ttcttcatga agaatcctgc ttttgacctg 3149281 taacgaaggt tagccgttaa aacataggga atattcaatc tattccgttc cgtcttacca 3149341 ctcccgggcg agttcaaaga agaatcaggc tgcgtcgcac caccccgcag ctctctgttc 3149401 tgatcacttt cttttactgc tcccaatcta tgtgttttag ttttctgaaa aactcaaatt 3149461 ttatgatctg aatatattaa cataatatac gtgcttctct tttaactgtc aataacttca 3149521 gagaaaaaag aaactgttat tttgtccctt ttcgaatggc tttccaaaag gattctgact 3149581 cgtttcctaa tgcgtaaact gaaacacctg ctattttata ttgctttgcc agatggcttt 3149641 tcgtttgaac ggttttttcg ttttcatacc acacgacatg tttatgcttc tttttgtcaa 3149701 cataagaaaa cgtcatcgag cctgattttt tgttgaatgc cggctttgct ttttgttttt 3149761 tgatgaggga tttgagctca ttccattccc ttattgtgct ggtacttccg tcttttacat 3149821 cccagtcata gccgtacgca gggattccca tgatgacttt attggctttg atctttttga 3149881 ctgaaaactg cagagagctt ttgatccagt ttgtgcttgc cactgacccc ggctcacccc 3149941 aaatgccgtg ttcatcgtag gtcatgactt gtacgaagtc ggcatatttg ccgattttcg 3150001 cataatcata cggccagctc cagtcatcat ttttatcatc ggcgcttttg gccggaacgg 3150061 ataccattgt tttaatatgt ttcttattca aagcctgtga gacatattga atgaagttcg 3150121 agtatgcagc gcggtcttct ggatttactg cttcaaaatc gatattgatt ccgtaatatg 3150181 agtgcttttt ggccagtgta attaactgat ctgtgaatcg ttttttcgct gttttattgc 3150241 tcatgacccg actcgctaaa tctccgtcaa aatcataaat ggcatcatta tagtttgaaa 3150301 tgacagccca tgtcttgatt tttttctttt tcgcatatgt cagctgctta gttggggcat 3150361 cgccaatgat ttgtccgttt ttttcaaacg caaatgtatc ggttgcgatg gcattcatgt 3150421 atgtatgata tttcgtaaga gaattgtatg aagccgtatc cccagtcgtg tagcctactg 3150481 tcataccggc tgccttcgct tctccttttg tatacataaa cagaacaatc gcaatcgcca 3150541 gtgaaaccgc tatgatcagc cattttttca tcgcatttcc tcctgtatca agtcatactc 3150601 ttctcatcgg ccaaaaaatt ggaagttgaa gttttttcaa gcaaaaagcc cggcatatgc 3150661 ctgccgggct tcctgagttc agcggtcaga gacgagaata tatgctgcct ttactggtcc 3150721 atgcaccccc acaactaaat ccatttcaat gtcggctgag ttactcggtc cggtaatgta 3150781 gttgatacat gaaggaacag tgacaccgtt cgcaatgttt tggcggatga tatcactggc 3150841 ttgtgtcatt ctcggtacaa tgcttgattt cggcacgatc gcaatataag tcgttggcaa 3150901 aaggctgaca gagcggccga tgtcttttga ggagaagagg acaaccgtcc ccgactcagc 3150961 caatgtaatt tcgctgaatg taatccctac attggcttgc tccgcttttt taatattttc 3151021 ctcgcctttg tcagcatccc actcccagac cggcgttcct tcactcggcc agtccttggt 3151081 gagcaggctt ttcagtccgt attcttcaaa gcgggggtcc ttcggaatga tgacagggcc 3151141 tccagaaaag cggctgactt gctcgcgcag ggcatcgtaa aggccggttg aatccgtttc 3151201 aatcagctct gtatggattt tgacacaatg gtttttgagc actgtgacta agtcatccgc 3151261 tgaataacct tcaagtgttt tatattgcgg ctgatgcgcc cattcaggga ctgccacgcc 3151321 tcctgttctt cgttcacggc ccaggctgga tgcgattcgg tttaaaaagc tctcttgatt 3151381 ctgaatggtt cccttcgtca tcactgctcc tccttcgtgc gttcacttgt ttctctgtcc 3151441 gcaaaccagt ctctgaatct cgatttatgc ggtgccggga agtcgcgaat ctgggtccaa 3151501 tttttaagcg ggccgggccc tttcgaaatt ttttcgtcct ctgtaaaagg cgtcatggcg 3151561 gccggcgccc attttgagcc cattttgtaa agcgataagg aggatgcgcc aagtccgaat 3151621 gctttcattg caagcttttc actgatcggc gccctgcctt ctttttcgac gatattctga 3151681 cgatgcttga gtagcagctc atgaagcggg attttgaccg ggcaggcttc tgaacaagca 3151741 gcgcacagtg aagatgcgta cggcagctcc ttataatcgt cataaccgcc gagcaacggt 3151801 gataaaacag ctccgatcgg ccccgagtag attgagccgt atgaatgtcc gccgacatgg 3151861 cggtacacag gacagacatt gatacaggcg gcacagcgga tacattgcag cacagactgg 3151921 aattccgttc caaggatatt ggatcgtcca ttatcaacga tgacaagatg gaattcttcc 3151981 ggaccgtcca cttcaccttc cagcttcgga cccgtcaaag ctgtaatata gcttgtcagc 3152041 cgctgtccga cagcacttct agtcagcatg ctgactagca cttcaaattc agaaaatgac 3152101 gggacaatcc gctccattcc catgacggta atttgtgttt tcggcaaggt gctcacaagc 3152161 cgtccatttc cttcattggt cacaaggctg acggaacccg tgtcagcgat ggcgaagtta 3152221 cagccggtaa tgccgatatc cgcttccaga aactttttcc ggagaatggc gcgcgcatgc 3152281 atcaccagct cttccggttt ttctgtatgt tgatagtcca gtctttcttt aaacacatcg 3152341 cgtatctgct ctttattttt atgaagagcg ggcgctacga tatgtgacgg cggatcgtga 3152401 tcatcaatct gcaaaatata ctcgccgaga tcggtttcta cgacttcaca gccttccttc 3152461 tccagcacct cattcagatt gatttcctct gtgaccattg atttagattt cacaattttc 3152521 ttcccgttct tcttttgaat gacatcccga atataggaag acgcctcttc cgctgttttc 3152581 gcgaaataga catgtccgcc tcttttcgcc acattttcgg caagctgtcc gagatagaaa 3152641 tcaaggtttt caaggacatg ctgcctgatt tcctctgata atgagcgcca ctcctcccag 3152701 tttcccagtt cttctgctgc ctctaggcgc cgcgtccgca gacgctcctg tgcacctgaa 3152761 acagcgcctc tcataaattc attatcaatc ccctgtgata cccgctcttt aaaagcgtca 3152821 gtaccgattt tcatcgccat gatcctttcc ccctctgaat ccagttttat ctgctgttga 3152881 gcacttcggc gatgtgcatc actttgacat tcttatcttt tcggccaagc cgtcccccga 3152941 tattcatcaa acagccgcag tcagcaccga tcagcacctc tgctcccgtt tcctccacac 3153001 attcgacttt ttcatcgacc atctgctcag aaatctgcgc catcttgact gagaacgttc 3153061 ctccgaatcc gcagcagtta tgtttgcccg gaagctctgt aaactgcagg cccttcacat 3153121 ggctcaacag cttcatcggc tccttccgaa cacccagcag cctagtcata tggcacgacg 3153181 tatgtaaggt cgcttttgta tgaagggtcg cgccgacatc ctctacccca aggacgttca 3153241 caataaaatc tgtcagttca tacgttttat ccgccagctt tttcgcttta tcggcccatt 3153301 tcggatcatc ctgaaacagg tgcggatact cccggaacat cgttgtgcag gaacccgaag 3153361 gactgacaac atattcggaa tcctgaaacg tttcgatcat ccgtttcatt gcttttttgg 3153421 cgtcatgtac atagccgctg ttgtaagccg gctgtccgca gcaaatctgc ccttctggaa 3153481 aatcaacctc gcacccaagc cgctccagca gctcaaccgt tgcttttccg acatttgttt 3153541 gaaacatatc aacaagacaa gtgacaaaaa gtgagacttt catgatgaac ccctctctca 3153601 tccccaatat atgatcaggt catctgatga cctgagttaa aataactata tgaatatcgt 3153661 acactattct gacaatggaa ggaaagagtt ttctagggat attttcattt gtggcatatc 3153721 aaaaacactc ccgatctccc aggagtgcag tatatggtta gatccagccc ttttcctcag 3153781 cgatgctggc ggcttctgtc cgatttttcg cattaagctt ttggatgatt tctgagatat 3153841 agtttcgaac tgtgccttga gataaataga gctccagcgt aatgtctttt gttgtcttgc 3153901 ctaaagccgc aagcctcaga atttcttgct ctctaacggt tagcggattt tcgtctcgca 3153961 tcatattaaa cgtcagctca gggctgaaga cacgttttcc ctttacacat tttcgaatgg 3154021 catcggccag atcgtcaatt tcaccgtctt tcagcagata gccatgtgca ccggccttta 3154081 cggcgcgttc aaaatatccg gggcgggcaa aggtggttaa aataatgacc ttgctgacgc 3154141 agcctttttt cattaattcc tctgccacat tcagcccgct tcgaaccggc atttcaatgt 3154201 ccataatgca tacatccggc tccagcttca aaatagcatg tagcgcctct tccccgttta 3154261 atgcttgtcc gatgactgtc atatcctctt ctaaatcaag caaagatccc aaagcgccta 3154321 aaagcattcg ctggtcctca gcaataaaca gacgaatcat tcttttcgtc ctccaatcat 3154381 tctgcttttt taataagcgg aatcgtcagt gccacaaccg ttccgttatg gtctgaaacc 3154441 gttaatcccc cttcaatgag catgagccgt tcttccattc cccacaggcc attcccaaac 3154501 attttctcct tcggcgctcc ctttccgtca tcccgtatta cgatcctcat tttgtcagca 3154561 aattgagaaa tggtgatggc acagtgggtt gctttgctgt gcttgataat gttagtcacg 3154621 gcttcccgca tacacatact gataatattt tgagtgacgg gagatatcac tgaaaagtcg 3154681 tcggctcctt cgtattgaaa ggtaatgttc cccgctctta atatgtgctg aatgtttacg 3154741 agctcctctg ttatcgtgac cgttctcata tcagaaacca gctctcgaac ttgcttgagt 3154801 gcggagcgtg aactggtttc catttctttt gcctcaagct tggtccgttc tggatcagat 3154861 gcagccagcc gctgaatgag ctggcttttt aatgtaagca gcgacagggt gtggccaaga 3154921 gtatcgtgaa gatcacgggc gattcgaaca cgttcctccc ttttagagag ttcttttatc 3154981 tgttcgttgg cttgtgcaag cttagcttca agctcaatcc tccgaaacat agaacgaatt 3155041 ccgaatggag aaatgagcat aatgacgaga aacgggagaa cagaaaaaag ctcccgaagc 3155101 gagaccgaat tcgcgataaa ttggtatagg catggaaaaa gcagtataaa gattaaagcg 3155161 cagaacgcac ggttaaaatt cgttttctct ttgtaataac caacaaagtt tgccggaaaa 3155221 aaacctaagt atatataggt gatattgtaa aacacactat acatcaaaat aaccgccatt 3155281 tgcacgataa gccaatatgt aaacgaagct ttgcccacgc tgcagaataa ctggcgatat 3155341 gccgctacaa aaaggagcag cataccatat ccgatcccct gtttgacccc tgattctttt 3155401 aataaagaga ggaacggcat aatcgtatac accagaaaga tataagggaa aaacccgaat 3155461 tccttcggga aaatagatat tgcctttttc atgtattaca ccgcttcttg ttttcttctt 3155521 atatatttag atagtagcat gaagagcatc atataagcga ttaatatcag aatatttttc 3155581 caagtcggac tcccaccccg gacaagttcc cacgctccgc tcccgaaatg ataagacgga 3155641 agccactggc caatgctctg catcatgtca ggcatgacct caaacggcat ccacatccct 3155701 ccgcctaaag ccagcagcat ataaagcaca ttactgattc cggccgctgt ttctactttt 3155761 ctcatgaggc cgattagtgt gcctaatgct aaaaaaggca atgcgccaaa caaaatccac 3155821 agtccgctca tcatccattc aaacggtgac aaggcaatat cattgatgat tgcgccgaac 3155881 agaaatatga cggtaattga taaaacgtga atgacacttt ggccgatcat ctgagctgat 3155941 aaatagatat gatccggaag aggcgtaagg cggataaagg cggcccagcc ttgtgaccgt 3156001 tcttgtacca ttcggatgcc aagcgtcatg atagaggaac ccatcacgct gaagactgtc 3156061 atcgacatca ggtaatgggc ttcccatgca cgttgatcag ggacgttggt attcactaca 3156121 tttgtaaaga aataataaaa ggcaatcggc atgatcagag accaaagcac aaagtacttg 3156181 ttcctaagca cccttttcat ttcagcgatg ctttgctttt gcagcacgtt cactcacatc 3156241 gcctccctgt tgccgtcagc cagctggcga aatgcctcat cgagcgttgc ttgctcaatt 3156301 cgaatatccc gtgcatgtat gttttcttga aagatcagcg ccaacacttt gtctgtattt 3156361 gatgtctgga tgatggttct ctcatgctcg tggatcactc tctcgacttc cgggtgacaa 3156421 gacagccttt ccaatgattc acttgaatga agcgtaaagg aaacagactg tttttgaatt 3156481 cttgagcgga tttgcattgg tgagccgtct gcaacaagct gtccttcagt aaaaaatagg 3156541 attcgctgtg cggcatcatc tgcttcctgt aaataatgag ttgaaaaaat aatcgttttt 3156601 ccttggtccg acagtccgtg aatggtctgc cagaatcggt gtcttgatga agtgtccatg 3156661 ccgactgtcg gttcatcaag tataagcagc tccgggttcc cggcaagagc caaagcaaag 3156721 ctcaaacggc gtttttgtcc gccggataat ttttctgctc ttgttttcaa atcttctttg 3156781 gtgagtgctg ttaacgaaac gagttctttc atggacaatg gattcggata atagctccgg 3156841 aagagttcaa ggatttcatc caccttaagg cccggcatga cacttacttc ctgaagcatt 3156901 acacctattt tttcacgaac ctgttgatca tcgggaaccc ggttaaatag tttgatttct 3156961 ccctcactcg gtttcagcaa tcctaatatc atcgagacga cggtcgtctt ccctgcccca 3157021 tttggcccga gaatggctgc aatttctcct ttttcaatac tgaagctgat gttgtttaca 3157081 gcggtttttc gctggaaatg ttttgtcacg ttgcttactg ttactgcttc tttcatcaca 3157141 tgagcacctc ctgatcgttt acattgattg taaaatgacg gagaagacga tgttagtatg 3157201 gggtgtcatg atgatggagt gacaaatgtc atttttttct caccccggtg tctaggcaat 3157261 cctcctcctg catcttccaa ttcatccatc ttttctatct cccatgtcct ctttctttta 3157321 aactgctgtg acattcatag aaagatacac tcttcaaacc atccgagtgt tatgatagaa 3157381 atattgaact ttatattact ttccggctga aaggagccaa tcatgaacga agcgattttg 3157441 tctagaaatc atgtgaaggt gaaaggcagc ggcaaagcat ctatcatgtt cgcacctggt 3157501 tttggatgcg atcaaagcgt gtggaatgcc gtggcacctg cctttgaaga agatcatcgg 3157561 gtgattttat ttgattacgt cggttcggga cattcagatt tgcgcgcata tgacctgaat 3157621 cgttaccaga cacttgacgg ctatgcccag gatgttcttg atgtttgtga agctttagat 3157681 ctgaaggaaa ccgtgtttgt gggtcactcc gtcggggcct tgattgggat gcttgcatcc 3157741 atccgccgcc cggagctttt ttcccatctg gtgatggtgg ggccttctcc ttgctatttg 3157801 aatgatccgc ctgagtatta cggaggattt gaagaggagc agctccttgg cttgctggag 3157861 atgatggaga aaaattatat cggctgggcg actgtatttg cggcaaccgt tctgaatcag 3157921 ccagatcggc ctgaaattaa ggaagagctt gaaagccgtt tttgttctac tgatcctgtc 3157981 attgcccgcc aattcgcgaa agcggcgttt ttttctgatc accgagagga tctttcgaag 3158041 gtaacggttc cctctcttat tctccaatgt gcagatgata tcatcgcacc tgcaacagta 3158101 ggtaagtata tgcatcagca tctgccttat agcagtctga aacaaatgga ggctcgcgga 3158161 cattgccctc atatgagcca tccagatgag acgatacagc tgatcggcga ttatttaaaa 3158221 gcacacgtgt gatataggaa cgaaagggat agaggtgacc ctcttagatg gacaaacaat 3158281 tgaatgatgc accatgcggt ttcctcgctt tgtcagaaga ggggtcgatc atagctgcca 3158341 accgcaccct tatcaagatt ctggattatg aaccggagca ggttatcggc cagcacatga 3158401 atatgatgtt gaccattccc gcgcagcttt tctgccagct ttattttttt ccgcttttga 3158461 aattggagca tcacatcgaa gaaatataca tttccctgaa agcaagagat ggagaagaaa 3158521 ttcccgtcct tatcaatgct attgcgagac acgatagcgg ggcttctgtc tttgattgtg 3158581 ttctgattcc aatgcgaaag cgaaatgaat atgaaaatga gctgctgata gccagaaatg 3158641 aggctcagga agctttgctt gccaaacaga aagccaatgc ggagttagaa attgccttgg 3158701 aaacgctgaa agcaaaacaa gaagaacttc ttgagatcaa taaacaaaat caacaattta 3158761 aattaaacac caaaagagag cttgaactcg ccagaaagat ccagaaaaac tcgttgactg 3158821 aaccgattgt aaacgatcag gttcagattg actcttatta caacgcatcg agtgaattgt 3158881 caggtgatct ttacggatat tatcaaatcg atgaacaccg ttacggcatt attatccttg 3158941 atgtgatggg gcacggaatt tcatctgcat tgattacgat gtctcttcat cctttgttcc 3159001 agcgccagat cacgcaaggt ctcagccccg ttaaagttat gaaggaattg gaccggcacc 3159061 ttcacagctt gtttcaaaat gatgaggaag caagacatta ttgcactgct atttatctcg 3159121 agattgatat agcacggcaa agaattgatt atgtcaacgc agggcatccg ccggcacttt 3159181 ggcaggacga tagcggaact caacatctgc ttcacgcgac ctcgcctccg atcgggatgt 3159241 ttgaagactt agagtttcag tcaagcagcc tttcatacac ggaggacgga agattgcttc 3159301 tgtatacgga tggcgtgatg gatcctacgg cttcatgtta tttatttgat ttactaaagg 3159361 atcatcctga ttcgccaatc gctgacctga aggagaaaat ccttacatca ctgcagcatc 3159421 aaaaggaagc tcatcataag agtgatgacg aatgttttat attagttgat gtaaaataaa 3159481 atgatccatg agacataaca atgatttgtt acatctcatg gatttttttg tttcagcgtt 3159541 tctttggaat atgtcctgac tccgcatatt gaaacacctg caaggaaggc agcgggtgtc 3159601 cattaaaatc aaataaagct tgattatcta cagcacttcc cccataccac ttcccggcgt 3159661 cttcagggtc gtattcagca gcatagctgg acgcccaccc tgacccgtat gtttcccata 3159721 acactttgtt tttctctatc tgtgtcttcg gcccgactgg aatccacgcc ggctcccagt 3159781 agaaaacacc aagtcctgct ttgcccgtat tcgccactgc ctccattaca tctcttactg 3159841 cagttgcctg gccttgaaca gaaattggat atggcaacgt ctgcccgctt tttggtgctg 3159901 tatttccatg cccatcgcca tcctcagcgg tataggtgta cgatgtctcc gccaccatga 3159961 cttttttgcc gtacgtattg gcaacagcct tcagcacgga ggtcaaattt tgtaatgtgc 3160021 catgccagaa aggataatag gagctagcaa acacatcata atccactttg tttttgctga 3160081 gtgtttctgc aataaatgaa taccttccag ccgtttcagg attggtaaaa tgcagggcga 3160141 ccaaaatatt tgaatttgtc tccctgaccg ctcggcttcc ttcattaaat aattggcaca 3160201 tcttcgtcca atcagtctca ccggcaaatc ctcctgttgt ttcatttccg acctgaacca 3160261 tgccgatgtc aacgccttcc ttgatcatct tttgcaggct ttgtttcgta tactcataga 3160321 gctttgcttt ttttgcttca aagctgagat tcgcccaggc tttgggcacc ttttgtttcg 3160381 ctggatcggc ccagaaatca gagtagtgaa agtcggccag caccttcatt ccgttcgctg 3160441 tcgctctttt tccgatttcg atggcttttt gaacatcatt gtttcccccg ccatacccgt 3160501 tgccatttga atcatacggg tgattccaga tgcggacgcg aacatagttg accccagcct 3160561 gttttaaagt tgtaaagata tcctggcgtt ttccgtttgt attgtaaaag gtgacaccgc 3160621 tgttttccaa agcaataacg ctggatacat ctgccccttt gataaaatcc ttgttcatcc 3160681 cctctacttt tttaacaaaa agatcctctg cccgaagctc tgacacgtgc ttctccttct 3160741 caatggcagc ggcatatcct gttgaactac atgcactcca cacgatggca gccgcaaaga 3160801 acattttcac tttgcttttc atgatttcat ccccccaaga cttagcaagc gttttcattc 3160861 tatagaaaaa agaatccgcc catatcgagc ggagcatcag cctaatgtgt gtttacgaca 3160921 attctcactt catacttttc catcgtcagg tcgcctgaca atatgtctcc tgtcattatg 3160981 tccttcacac tctgatcaaa cgtgaccagc tgtttttctt ccgtgaaatt catgacaaaa 3161041 atataatcat tgtcctgatc ctgcctcgct tgtacggaga cgccttttcc gtgccgaacc 3161101 ggaaaaactg gagagagaga caggtctgtg atcagaccct catagaaatc acgctgaaat 3161161 tgatcctcca aacgcgcgcc gataaaatac gccttgccct gctgatactc atggcttgtg 3161221 accgctggcg tgcgcgcata aaaatcttct tgatacaccg cttccactga agctgtcttt 3161281 acatcaatca cggttgcata atccttcatt tcatatattt ggctgcggta gctgacagcg 3161341 tttcgatcct tcggatacag ggtgtccgtt tcaagaggct caactccaaa tatagcttga 3161401 agatccggat gccatccgcc tgtgtatgtt aagtcatgct cattcacaac cccgctgata 3161461 tacgtcatga ctaaggtgcc gccgtcagcc gtaaacgctt ttaaacggga aacggtgtcc 3161521 tcgctgatta aatacagcat cgggacgatc agcagtttat atggtgaaaa gtcttgttct 3161581 ttcgtgatga cgtcgacagg gatatcgtgt tcccagaatg tgcggtaatg ctgctgaagc 3161641 gtttgcggat aacgttttgt cgccttcgca aacccctgag catcctcgag cgcccaatga 3161701 ttttcccagt catataaaat cgcggtttga gccggcctct tcgttccgac aacttcggac 3161761 agccgttcca atgtctcgcc taccttggcc acttcttgaa agacgcggtt cttcgggcta 3161821 ttgtcatgat ccacaaccgc tccgtgtaat ttttctgatg acccccgtga tttgcggtat 3161881 tggaaataga gaacgctgtc cgagccgtgg gcaatcattt gcatggatga cagcagattc 3161941 atgcccgggc gctttgcctt gttgacgtta tgccaattga ccgcgcttgg cgtacactcc 3162001 attaataaga agggctgctg cttcaagctt cggtacagat cattgataaa gccgaccttc 3162061 atcgccaaat cagctgtgct ttcccagtca ttgtgccaga caggataagc gtcccagctg 3162121 atggcatcga catgctttgc aaatttgctg tagtcgaggc cctgatacgg gatcaaatcc 3162181 ggtgtgtcag ccataaaatt cgttgtgata gggatatcag gcgtcaattc tttcagcgga 3162241 atgatttcat tttcataaaa cgaaatcgtt tgatcggtga cgaaccggcg ccaatctaaa 3162301 ttcaggccat gcaagccatt ttcaccgatc ggcgaagggc tttcaatttg tgaccagtca 3162361 ttgaacgtat ggctccaaaa aggggtccac cacgcatggt tcaatgtctt gaggctgttg 3162421 tcatatttcg atttcagcca ctcccggaaa gcatgctggc ataaatcaca gtggcaatct 3162481 cccccgtatt cgtttgaaat gtgccacatt aacagcgccg ggtgatgtcc gtatcgttct 3162541 gctaataagc ggttgatgtg ccgtgttttt tctcggtaga ctttagatgt gaggcagtgg 3162601 ttgtgccttc cgccgtgcag ctgtttgacg cgggaggcat tgacgcgcaa aacttccgga 3162661 taggtttgcg acagccaggc cggacgggct ccgctcggcg ttgctaatat gacccggccg 3162721 cctatactgt gaatccgctc aaaaatatca tccagccatt caaattgata tacgccctcc 3162781 tccggctcaa gtgcgctcca tgcaaaaatg ccgacagaaa acgtattcgt atgagaaagc 3162841 ttcatcagtt tgatatcgtc agctaaaata tcgggccgat ccagccactg atcggggttg 3162901 tagtctcccc catggagcat aaattttgct tttgttacgt gcgttttttc aagctttgac 3162961 atcacattct cctccttgtt ctcttagccc ttcgttccgc ctgcggttaa tccggacaca 3163021 aaattctttt gcagcataat aaagatgacg gcaaccggta tgctgataag cagggctccg 3163081 gccgcaaatg tcgtatagct ggcccccatg acatcattca ctaaattgaa tagaccgacg 3163141 ggcaatgtat atgattcagg cgttctcaat atggttgagg acagcacaaa atctccgagc 3163201 ggaccggtaa agccgttcat ggccacgact gccgccatcg gttttgataa tggcagaatg 3163261 atctggaaga agattctggt gctgctggct ccgtcaatct tggcgctttc gtctaaatcc 3163321 atcggaatgg aatccatgta ccctttcatc aaatacgtat tcatcgggat caggccgccg 3163381 atataaagca agattagcag ccagtggcta ttgatcattc ccaagatttg cgccagcaca 3163441 aacaaggcaa ttaaagctga aaactgagga atcatctgca gcaataaaaa gagcgttaaa 3163501 gcgtatttcc tccctttaaa ccgaaagcgc gaaaacgcat aggccgtaaa cgtcacacag 3163561 agcaaagacc ctgccattgt aaacaggctg atcttcatag agttgacata ccactgcaca 3163621 tattgaaggc tttccttgcc cgcaaataat tccttgtaat gatcgaatgt cggatgcttc 3163681 ggaatgatgg atgtactgat taagctgttg ccgggattaa agcttgcgcc tgccgtccaa 3163741 aggagaggat aaacaatgat gaccgccata aaggctagca acaagtaaga gaaaaggaga 3163801 cggatatatc ttctgacttt catatctgcc agcatacctt atgcctcctc tttaaaagac 3163861 tttgtctgtc tgaactgcca caatgcgatg gagataacaa atacagataa taaaatggtt 3163921 aaagccgcag caagtgaata ttggctggac tgcattgtca atttataaat ccatgaaacg 3163981 aggatatctg tcccgccggc tgttgatccg gttacagccg gacctccgcc attgaataga 3164041 tagataatat taaagttatt aaagttaaac gtaaactgag taatgataat cggagccatt 3164101 gcaatgaaca ccatcggaag cgtgatgtat ctcagctttg aaaagacaga agcgccatca 3164161 atcgtagctg cttcatacag atcgtccggg atggattgca atacgcctgt tgagacgaga 3164221 aagatgtacg gaaatccgag ccagccctgc atgagaatca atgcaagcct cgaccaattg 3164281 gcatctgtca tccacggaag cggatctatc ccgaagaaag ccaagatgtc gtgattcatc 3164341 gcaccgaagc tatcattaaa cagtcccgca aaaattaaaa tcgtcacaaa accgggaacg 3164401 gcccatggca aaatcagaat cgtccgaaaa aaacgtttaa accgaaggtc tttctggtta 3164461 acaatgatcg cgagaaaaat ccccaaggtg acttgcagtg tggatgcagc aagtgtccaa 3164521 accaccgtcc aagccagtac atcaaaaaaa gtcgacctcc aaatatcaac tgtgaaaata 3164581 tttgcgaacg tttgaaaacc gacccaatca attaattttg caggaggaga atgatacaaa 3164641 tcatagtttg taaacgctaa tgcaaagctg aataagatag gaaagatcac ggcgaaaatt 3164701 aaaataaaca aagatgggcc gctgacgaca taaggatagc cctcagaaat gatatgctgg 3164761 tattgttcct ttaaggaact taatggctta ttttcatcac gctgttttcc gctttggaac 3164821 gcatcgcgaa gatttacata atacaccgca aggccaaagc aggtcacgat gacagcaata 3164881 atcccttccg ccagcagaaa aacggaatta tcccgcggca cttctgttcc cagtgtaaag 3164941 attccccaaa accccatatt gagcagatct ccaaagaccg caaaaaacga tgcgcctaag 3165001 aaaagaaaga caataccttt tatccattgc ttgttataaa attgcccgag tcccggaatg 3165061 atagaaagca acaaagcgac ttgacgatgc tgcaccgttt tcacctctct tacaatacaa 3165121 atctagcttt ctctttattt tccgctgtgc tttgccttaa tttgtccttt ggccgtttca 3165181 gctgcttgat ccaatgcttg tttcggatct gccttccctg ttgcaaccgt ctgtaatgct 3165241 gaatcagccg gcgtccatat ttcattcatt tccggaatat ttggtgttgg ctctgagaaa 3165301 cgggattgtt cagtaacagc ccgtgccgcc tcgcttttca taatagccgg gtcattggct 3165361 agggatttca cagcaggaac ttctttcgtt tcttcatatc gtgttttaga atttttttca 3165421 tttgccagga aaacggctaa ttcttgcgcc agctcttcat tctttgaaaa tgcactgacg 3165481 ttgtagcttt tgacgccgat aaaggagctc atgtttttcc cattttccag cttcggcagt 3165541 ttcgtaatgc cataattgat tcctgcattc gaaaaggctt ctacattcca tggaccagaa 3165601 ataattgcgg cggcttttcc ttctgtgaac agcgattcca acacgttaat cccttgttct 3165661 ccaataatgc cagccgggaa caggccatct ttgtaaaact tctgaatcag cgccgcacct 3165721 ttgacagctc cttcattatt gattccaatg tctgacgggt tatagctccc atctttggcc 3165781 tttccaaaaa tgtatccgcc atatccgctc atcacacttt ctgcataata aatttgatcg 3165841 aatagggcta aaaagccaaa tttgctgccg tcagcagtct ttttggaata gtcgtaccac 3165901 tcttccagcg ttttgggcaa ttccttttct gtgatgagat ctttgttgta aaaaagcaca 3165961 gtcgtttcga ccgcttttgg cagtccataa agcttttgat ctaccatttg agactgaatg 3166021 gaagcgtcag tataaagtga ttgaacgtct tttttgacat gtaattcctt gagtaatcct 3166081 tccgtgacag cggttccgat ttggtcccct ggcattgtta acacgtcagg gcctgtgccg 3166141 gccggtccat ccattcgcaa atcttcaatc tgcttggcat acggtttttc aacgactttg 3166201 accttcacat catgctcttt ttcaaatgca gccacagcgt ctttaatgcc gttgctcttt 3166261 tctttatcct cccatacaac aagctctgac ccttttgaac tcgatttggc gctgctgctt 3166321 tcctttgggc cgcaagccgc caaggataaa ctgacagctg cgcagagcat gaatacggaa 3166381 cacttttttg ccattttcat tgattgtcac cctttcggta ggaatgaaag cgctttaaag 3166441 ataatatagc atgcctgaga aaatgtgtaa acaaactatt tacttcatag agtaaatttt 3166501 tttacctaaa taaaaaatga cttagtgtcc taagtcatcc ttaattcata ctcttcctga 3166561 cgattaattc tgcgcccaca tataatgttt ttaccgttct tctcttgtcc tgcacttgtt 3166621 caagcagtaa ttgaacagcg tttttacata attcatgtat atcaatatga aacgtcgtca 3166681 gaggaggcga gacatacttc gcgaagctga tgttgttgat actcacaatg cttaccctgt 3166741 ttggtatggc aattcctttt tcgttcaggg cttgcagaca gcccactgca atcgggtccg 3166801 ctgcaatcat aaaagcagtc ggaagctgat cgcctaatgt gtcgatcgct gctgacatca 3166861 ggcggtagcc gttttctaca gagaatccgc gatgacagaa aatatagcgc tcgtccagca 3166921 tggctttttc cctcatatag gatctgaagg tttgttcacg gatgtccatt tcatcctgat 3166981 tggtattcgg atttttgtat gtgccgccga taaaaccgat gctcttatgc cccttctcag 3167041 tcaggatgtt taccgtcttc cttgtcattt gtgccaaatc gggccttacc gagtcaaaat 3167101 gatcgggatc aggagttgaa tcgatgaaca cgccgttttc agtgagattt ctgaggaaag 3167161 ccagctcttc atctgaaaat gtgccgacgg caataaaccc ttccgtatgt tcaggaatgc 3167221 tctcgattcc atccgctatt ttataagtgg tcatatcgac attgaatgct ttcgccagtt 3167281 tctctacttc taatctcatc gttttaaaat agacatcttc taattcttct ttatctgtca 3167341 gccaatataa aaacgcaata tgtttcacca gcggccttac tgtttttttg cggtaattga 3167401 gcttttccgc cgcttcatag attttctccc gtgtctcatc aggaacagaa aggctttcat 3167461 cgttatttaa aacgcgggaa acggttgaga ttgaaaatcc cgcttcctgc gcgatatctt 3167521 taattgtcgc cattgtatct gcctccatta ttcagctcgc attgttttag taaaatattt 3167581 tactttcttt ttcacaaatg tcaagtgcac aaagccctct ggctgccatg taaaaagact 3167641 gaaccatttg cggctcagtc tcagttgttc gtatcattcg gaaccggcgg aattgcccgg 3167701 gaaatgagtt ggttattgca cattttcctc gaaatatccc gaaagcacat cttccacatt 3167761 cgtcaaatgc gccagcatgg cggcttccgc ctgtgcaccg ttcccggcag ccacagcatt 3167821 gtaaatccgt tcgtgctcct catacagccg ctgaacggag gtcttcttgg aaaacagcca 3167881 gattttcctc gtttccctca ttgtttccag cagcaatgat gacacgtgat tcatcaagtg 3167941 tttaagaagt tcattttgag aagcgtccgc aagcgcaaga tgaaatgcaa agtctgcttt 3168001 ctctcccagc tccccgtccg cttcaatgct gcccatttcc tttagtgcat cctgaattct 3168061 ttcgagatct gcttctgtcc ttttttcagc cgctagtgaa gccacgccga tttcaagcag 3168121 ttttctgacc tcgagcagct gcttgacgtc ctcttttttc atcagaaggg cggctgagag 3168181 cggctgagaa atttgattga gctcaaattc cttcagatac gtgccttctc cctgtttcat 3168241 ttcgacaagc cccatcgctt ttagcgcaga aagtgcttcg cgaaccgctg aacggctgac 3168301 ttgaaagctc tcagcaagcg cctgaacaga gtccagttta tcccccggct tcaattcgcc 3168361 atttttgatc atatctaata gggcatccgc tacttcttca tatatttttt tgttttaatc 3168421 tgtttatatt tcaatgcaat tcaccccgta acttgtaggt ctggctgttt acgatctatt 3168481 atactctgtt ttgtgggccg ccaaaagatt ttgactattt tgtcaaaaag tcttgtactt 3168541 tgattttttt caaaatataa tgctaggtaa ctggtcttat tacccagtca tcagatgatc 3168601 atatcatcta tagaaaccgc ttacatatgg cgccagttta tgtttcaagg aggggtttgg 3168661 gatgcaatgg acacaggcat atacgcctat agggggaaat ttgctattat cagcgcttgc 3168721 cgcacttgta ccgattattt tctttttttg ggcactcgcg attaaacgga tgaaggggta 3168781 tacagcaggc ttggccacat tggggatcgc ccttatcatt gctgtattgg tttatcgtat 3168841 gccggcggaa aaagcgctga tgtccgcgac acaaggagcc gtatacggat tgttgccgat 3168901 cggctggatc attgtgacgt ctgttttttt gtataaaatc actgtgaaaa cgggacagtt 3168961 tgatatcatt cgcagctctg ttctctcgat tactgatgac cgacggcttc aagctctctt 3169021 gatcgctttt tcattcgggg cttttttaga aggggcagca ggcttcggag cgccggtcgc 3169081 catttctgcc gcgctgctgg tcggtctcgg ctttaatcct ctttatgctg cggggatctg 3169141 tttgatcgcc aatacggcgc cggttgcctt tggggcaatt gggattccaa ttacagccgt 3169201 agaagggccg acagggattc cggcgatgga gatttcgcaa atggttgggc ggcagctgcc 3169261 gtttttatcc gtatttattc ctctttattt aatcatcatc atgagcgggt tcaggaaagc 3169321 cttggagatc tggccggcga ttctcgtatc cggtgtttcc tttgctgttg ttcaatatct 3169381 cagttccaat tttttagggc ctgagctgcc cgatgttttg tcagctcttg tttcaatggc 3169441 tgcgcttgct gtgtttttga aatggtggaa gccgaaaaca acattccggt ttgccggtga 3169501 acaagagtcg gccgcctcaa ttgaaacggc gcgcacaaat ccggcggcgc ctgcatacag 3169561 aggcggacag atttttaagg cttggtcgcc atttctgctg ctgacggcga tgatttccgt 3169621 atggggcatt ccatctgtca aatccgcgct gaccgggcat tatgaaggct ctgcggtgtt 3169681 cttgaagtgg ctgaatgctg ttggagaaaa actgactttt tcccccggtg tgcctttttt 3169741 gaacaatcag attgtcaatg ctgacggtac gccgattgaa gcggtttaca agttggaggt 3169801 gcttggttcg gccggcaccg cgatattgat tgccgcagtg ctgtcaaaat tcatcacggc 3169861 gatttcgtgg aaagactggg gaaccgtttt taaagaaaca gtccaggaat tgaagcttcc 3169921 gattttgacc attgcttctg tcgttggttt tgcctatgtc accaactcct cgggaatgag 3169981 cacgacactc gggatgacac tcgcgctgac aggttcgatg tttaccttct tttcgcccgt 3170041 tctcggctgg ctcggcgtct tcattaccgg ctcggatact tctgccaacc tgctgttcgg 3170101 caacctgcag aaagtcaccg cattatcagt cggcatggac cccgttctgt ctgtggccgc 3170161 caactcttca ggcggtgtca caggaaaaat gatttcaccg cagtcgatag cggtggcgtg 3170221 cgccgcggta ggactcgccg gaaaggagtc agatcttttc cgctttacca ttaaacacag 3170281 tctgtttttg ctgctgctcg tctgtatcat cacctttttg cagcatcacg tattcagctg 3170341 gatgattcct taaaaaaatc ctcccgtcta gggaggattt tatttatatc gctttctcgc 3170401 tgccgatgac ggaatattca tttgatcgcg atattttgcc acggtgcgtc tcgagatttg 3170461 gatgccgtgt tgttcataca gcaaatcgac aagcttttgg tctgaaagcg gttttgtttt 3170521 gtcctcttga ttgatcaggt tttccagatg cgttttgact gcataattcg acgcatctcc 3170581 atcacctgaa gcctcggctt ttgctgagaa aaagagtttc atctcaaaca gcccgtaagg 3170641 cgtttgtatt gttttccctt taatggcccg gctcacagtt gattcatgaa ggcttagaca 3170701 gtctgccacc tctctgagag tcagcggctt cattgcgctt cgccctttca gaaagaaatc 3170761 cttttggcgt gtgatcagtt cattgataat tctcgtgatt gtctgttttc gctgccgcag 3170821 cgcgcggctc agccagcgcc actcctgata tttcgcagat aaataggaga cagtatcctg 3170881 acaggagccg gatgataaaa gcgttctgta ctgcggatgc agatcgatct cgggaaacga 3170941 gcgggtattc agttccgctg cgatgtgccc attttttacg gtgataaaaa tgtcaggctc 3171001 aatatacaca tcttgctctg gccgggcaaa cagaaggcca ggtctaggat gaagagccgc 3171061 gatatcatct gagatatctt gaatggtatg aagcggaatt cccgtctcta ctgaaagcgt 3171121 tttccatttt ttttgcgcaa aagcatcaaa atgagctgaa accagcattt ccgcttgttc 3171181 atttctgttc ggcagccgct gtaattgaag aaggatgcat tcctgcaaag atctcgcgcc 3171241 gattccagcc ggttctaacg actggagttt tgccaaaaca gcctccgctt ccttggccga 3171301 tacagataat cgccgtgctg cctcctctat atcttcttcc aagtacccgt ttgaatcaag 3171361 cgaatgaatc agataattaa aaatcttttt ttcagtgttt gtcagattca tatcgagtga 3171421 ctgctgtttt aacgcatcct gcaatgtttt ttgcggatta cttaattgaa ggcccgcttc 3171481 ctgtgcattc atcctgtttt tgtttgtttt atggtaagat agtggcggtg tgtctgtttc 3171541 ctttcgttca ataagagggt tttccagtga gagctcatca atgtactcgg cgagttctgc 3171601 cgaatgatag ccaagcagcg tgatggcctg cctgagctcc tgtgtcagtt gaggctttaa 3171661 tacttgtact tgctgaagtt tcatatccat cttgctcact cccctttctt cattgtacat 3171721 gattgagatc acaccgtata catttatgaa aaaggagctg ccaaagaaat gtctgaactt 3171781 ttttccgtcc cttattttat tgagaattta aaacagcata ttgaaatgaa tcagtctgag 3171841 gataaaatcc acgcgatgaa cagctactac cgttccgtcg tctcaacact agtgcaggac 3171901 cagctgacga aaaacgcagt tgtcctgaaa cggattcagc atttagatga agcatacaac 3171961 aaagtcaaac gtggagaatc aaaataaacc ttccgctcac atgtgagcag gaaggttttc 3172021 cttctttgag gcgtgctgga tgagacgggt gcttggcacg ccttccatcc aggtatgaaa 3172081 gtaattggcg tttttcccgt aggaattatc aatgaccgtg ttttcttttt gaagaagaga 3172141 agacaggatg tggccgtgca gccttgatgt ttccaccgat tcgtaacggc tgaaaaaccg 3172201 aatcgctttt tggacgatat aatccgagta tttttcccat atatacgcaa tgggcaaagg 3172261 gttgcctgct tttttattca agacgttcag cgtttggaga aaagcaatcg tccggcggtc 3172321 tgaagctgac agcaccgtgc gccagtcgta gctttccgct tctgcgtgtt cctgaagcgc 3172381 ctggtttgct tcatgatctg ttcggataaa tctcagcttt tgattggacg gctgctgcgt 3172441 gggaatgacg ggaaacagct gatgagccat atcaggcaga agctgaatgt gatttgttgt 3172501 aaaataggcc tgtgccgtag cataggaggc tttttccctt gtcatgatgt gaaggttcgc 3172561 atgcttagaa aatatctctg ccgtccgctt gaggttgtct ttgttttgaa aataaatcga 3172621 ttgcggcagg atcacaattt tgtggttcgg ataggtttgg acgattttct ctctaaagcc 3172681 ttgataatac ggatacagat ccccgaagtt tccgcctccc tggcagacga tgatgagatt 3172741 cggatcaagc tttcgcccga ttgggaaatt gtctggattc cagcgttttc tgacccgaat 3172801 cccgtgttct ttaaagaagg cttctgttcc tttcataata aataaatccc ctacattccc 3172861 atatagagga tagtcagcat atataatctc tgattgtttc ggaatgacgt cgagcagccc 3172921 ggacagtttc tgtttcaggc tgatcatcga atgcttgctg tccatttctt cacctcgaca 3172981 gtatggaata agtgcagtag cacttcaatg acccggcctt gctcatcttc tgtcatattg 3173041 gaccccgatg ggagacagat tcctcgcttg aacaaatctt cgcatacgct tcctgtatct 3173101 tcatgagaat aaaataaagc cggatcgaac agcggctggg tatggagcgg cttccacagc 3173161 ggacgggctt caatgttttc ttcagcaaga cgttgaacta tgtcatatgg gctgagcccg 3173221 ttatcaagtg tgagcgtggt gagccagcga ttggatacgc ctgctgcgta ctctggcata 3173281 aagcggacgc cgtctaagtg accgagcgca tttttgtatc tcgtgaaaat ggtccttctt 3173341 ttctccactc gctcatccag cacctcaagc tgggcaatgc cgacgccggc taagatattg 3173401 ctcagcctgt aattatgtcc aatttcactg tgctgataat gaacagccgg ctctcgtgcc 3173461 tgcgaagcga gaaatcttgc tttttcaatt gcggcttcat catttgaaac gagcatccct 3173521 ccccctgatg tggtgatgat tttgttcccg ttaaatgaaa aaatgccgaa gcgcccgaat 3173581 gttccgcttt gcttcccttt atagactgtg ccgagagatt cggctgcgtc ctcaatgaca 3173641 ggaactccgt atgcatcaca caggcttacg atttcatcca ttttcgcgct ctgcccatat 3173701 agattgacgg caattaccgc ttttggcagt gttccgtttc ttttcgcttc ctccaatgct 3173761 ctttcaaggg ctgtcggcga catattccac gtatcaggct cagaatcaat aaagacgggc 3173821 accgcttttt catatagaat cggattggcg gttgctacaa atgtgaagga ctggcaaaac 3173881 acgctgtcac cttcttttac ctcaagcaaa cgcagcgcga gatgaatcgc cgccgttcct 3173941 gagccgaccg cagctgctgc ttttacaccg actcgttctg ccagctgttc ttcaaatgaa 3174001 ttcacgagcg gcccaagcgg cgcaatccag tttgagcgaa aggcttctga aatatagtgc 3174061 tgctccctgc cgctcatatg agggggagat aagtagattt ttttatgcat agaatcatcc 3174121 tttgtttgat gtttgaatgg aagaaatgat gcgtgccgga gcaccggccg ccgttaccct 3174181 gtccggtatg gaacggatca ccgcggagcc ggctccgaca atgctccaag ccccgattat 3174241 gatctgcggt atgacggatg caccggttcc gacgtgagcg ccttcctgaa cggaaaccgc 3174301 tcctgacagc gtggcacgcg gggacagatg aacgtaatcg ctgatttgat tgtcgtgctc 3174361 tgccactgca cccgtattga tgatgcagtg ggcgccgatg cgcgcatccg cctgaatgat 3174421 cgcgcccgcc ataatcactg tcccttcccc aatgacagcc gacttgctga cgatggctga 3174481 cgggtgaatc aatgtaataa aatcatcttt ccccagtccc agtcgctccg ccagctgttt 3174541 tctgacactg ttattcccaa cagcaatcag aaacagcaca tcaggaatga gcctgcgcag 3174601 ttcagtaacg gctttcggcg gtcctgtgta ccattctttt ccgccttcga acgttttgaa 3174661 tttatcatcc agcaccgcgg ctaagcgcgt atctgagcgg gcgtttatca gctctctgat 3174721 cacctttccg tgaccgccgt cacccacaat ggccacattt ttcatgagga cacatctccg 3174781 cttccggtaa accgttccgc ggtcacatga ttggtttgct gaatcccttc tgaaacaagg 3174841 acctttcgca ccgtcaaaca taaaattttc aaatcgagaa aaaatgacca gttgtcaacg 3174901 taccaaacat ctaattcaaa tttcttttcc caggaaatcg cgtttctgcc attgatttgc 3174961 gcccagcctg tgatacccgg cttcacctca tggcgccgtg cctgtttttc tgtataaaga 3175021 ggcagatagt ccatcaaaag cggccgcggc ccgacaaggc tcagatcgcc cttcaggaca 3175081 ttcaggagct gcggaagctc atcaatgctc agctttctga tcagcctgcc cgttttcgtc 3175141 agccggactt catcaggcag cagatttcct ttactgtccc gttcatccgt cattgtccgg 3175201 aacttatata gggtgaacgg tttgccgtgc aggcccggcc ttacttgctt aaagaagaca 3175261 ggtgatccta ttttcagcct gacaacggcg atggtgaaca gaatgatcac acttgtacag 3175321 cacaacaaaa aaatggcggc cgtcagatca aaaagtcgtt tcaggatcaa agattcacag 3175381 ctcctttcgt ttttcgaaac cgttttaata ccagctgtct ttcctctttt gtacaaacga 3175441 gcataaaagc gaaaacagcg tagcaaaagc tgactgtcac tcccgtcgct atcaatgacg 3175501 gccagctgtc aatcttcaca atgaactgaa ttgccttaca gaccgtccag gcaaatacag 3175561 cggctgaaag aggcccgatt atgcctttaa ggaacacgtg ctttttgtag cctgtaatgc 3175621 gggatacgta aagcggcgta aagatggcat tttttaaaat aagagaaatg gcccctgcca 3175681 atgttatgcc gtacagaccg agatgagccg gcccgctcag cgtgaccgcc agcaccacat 3175741 tcaccgcacc taacagcagg gtaacaatcg ccggtgtttt ttgttgatta aaagcggtcc 3175801 atatataaaa cagcggcata aaggcgaggc tgacaaccaa gtatccggca tgaataaata 3175861 aaagcggtgc tatcgttgaa aaggacggtc cgagccagat tgtcagaaaa ggtcccgcca 3175921 atccgcccaa taaggcagca ggaagtgcaa gcaaaagacc attgagcctt actgccttat 3175981 tggcgtaatt catcaatcct tccatatcgc cttttgaata atatgaagtc atgatgggcg 3176041 caaacaggga tgcgaccgtt ccggccaagc tgcgcaaaag cagcggaaac tggataatcg 3176101 ccgcgtattt cccggatgca gacgccccca gcatcaaatt ggcggttaac agatcaatct 3176161 gcaaaaaaag caggacgccg atttgattga cggagctcca tgcgcccgct tgaaacagct 3176221 ccttgcttgt acggaatgaa agatccttca tacgaaacga aaaccacgga atcagctttt 3176281 tgaagaaata gaaagacagc acagacgcaa taacagcacc agctaaagct gcaagctgga 3176341 tctgccagat tttcggcgca aagcatgcaa acaggagcag cacagacagc acccgtataa 3176401 gcatttgcac cgcctgaatg gaactggtga tataaaggcg gttggcataa aatggtgcag 3176461 cgccgaagcc cgccatcaga aacgttaaaa taaacagcac actgccgatt aaaatcgaca 3176521 aacgcacatc tgccaaaagc gcttgcggca cattcatgac gcggtcaata aaaaaagccg 3176581 aacccgcaag cggcagcaag agcagcaagg aaatcaaaac agaggcggct aaataattgc 3176641 tgatatacgc atttgctttc tcccgctctc ccctgtgggc agcaacagaa aagaaccgaa 3176701 cgacaaccga gctgagcgcc acggtaataa ccgaaaagta attaatcaca ttttgtgtca 3176761 agtgaacaaa gccaaacgct tcgacaccga gcgttttgac aataaaaggc gtcatccaaa 3176821 ccgataggaa aacagacaag agaaaagccg tgagattcgc gctgaaattt atcgtgaatt 3176881 tcatgcctgc ttcgcactgc ctttcattgt cccccgctgc tcgaaaaaca gcttgatgag 3176941 aaaagtgagc cgccatttac acagtgctaa taccaaacgc tctcctctta ataatttctc 3177001 atgctgaaac ggtgtatgtc tgacagcctg ccgcaccatg tcataggata aaatctgtct 3177061 gatcttcttt ttgatgtctt tcggcgaatt cggagaagca caggcatttg ccaaaagcat 3177121 cggaagctgg tgcctgcaaa tgtacacatt caaatcttct ttacatgcgc ctgctaagcc 3177181 gtagtgattg tagaatgcga ttttagcctg atattgtttt tgaagatgtt catccatcgc 3177241 cggcttataa gggatttctg tcaggctgtt cgggttttca cgataaatgt acaatccttc 3177301 atcaagcatt ttcacccgct ccgcttcgcg aaaagcggac aaattaaagg gagagtcttc 3177361 agcaaaacgg atgtcttcat caaacagcag attcgccctt tcaaaaagct cacgacggta 3177421 aagataacgc catacatacc agataaatct cgtttcgtga gcatgtttaa gctgttcagt 3177481 catttctggt ttcgtcagca cgcggtttgc ctcaagctgc ggcggcacat atgtccgcct 3177541 gtccgatgac tgcttgtaaa aaccgcatcc gacgatgtca agctgatttt gctccgcttc 3177601 ttcagtcagc ctctggaaca tggcggatga tacataatcg tctccgtcta caaagccgat 3177661 gtaagtgccc cgcgcggcct ttattcccgt atttcgcgct gaactaagcc cgccgtttgc 3177721 ctgatgaatg acccggattc tcgcatcccg ttttgcatag tcctctgcaa tttcgcctga 3177781 acgatccggt gttccgtcat tcacgaggat gatttcaata tcagaaagcg tttgacgaag 3177841 caaagaatca atgcactctt ctataaatgg ttcaacatta tacatcggga caataatgct 3177901 gacgagcggg atcattgcgc ttcaccgctg attttgtcac gcagaccttt aaaatacaca 3177961 tctctcggaa agcctgcacg ggatgtttct tttgttaaaa gctcattgac tgcggctgtt 3178021 acgcgctctg gctccggatg ttctatcagc ttcatgaacg ggatgtcttt aagccattga 3178081 tagccctcca tcaccttatg gtcaaaggag cgaatgacaa cacacggcgt tcctgtcagc 3178141 gcgcaaaaaa tcatgccatg aagcctgtca gtgacgacgg cttctgcgct ttgcagctta 3178201 gaccacagtg cttcaagttc atgttcgcgt gtatcgcggc tgacccggcg gccgatcgtt 3178261 gtcgtaaagg atttgatctc gccgaattcc tcacatagcg cagccttgac ccggttcctc 3178321 tgctcctcct gaagcacgct ttcctgatcc tcgcgcaaac acatataaac cccttcgcgt 3178381 tctgcgggag ccttgcttct gtctaaatac agcaccatgt ccggctgctt caaaattgtt 3178441 ttttcttgaa aatgctgttt cataaattga tacgttgttt catcccgcgc catcagcaat 3178501 aggccggggt gcgcattata aattttctgt gcccgtttca gctctttgcg cccttttttc 3178561 gtgtcagaaa aatgagccgt tgccggaagc tggacaaccc gatagtcatg gaatgtttta 3178621 atgatgaagc ggcgcgtcca ctcctcataa cggtataaat cccccatgtt tccgccgccg 3178681 atgataaaga ccatatcctc cggatggcgc gagcggatca ggctttttgc tgatttgtaa 3178741 atgtccttca tatcgacctc gacgatgtca aagtccgggt attcttgctc aagaaatgcc 3178801 ttgctggcat aagcaattgc gtgatctccc aaattgtcat gggacggcag cagggtcagt 3178861 atgatttttt tctgatgtgc tgcggccttt accggttgat ctgccgctcc cagccaatat 3178921 tgggacgggt atttgacctt tagcagcagc cattctgcaa aattgatttt caacgattgt 3178981 aacgacatgt cctcaccctc tgtttctcat tttgtactcg atcacccgct gatacacagc 3179041 cgatgccata gcgacgaacg gaatcattct gtatttcgcc atcagaagca ggcatgaccg 3179101 ttttgcgtca aaaggagcag tacccgtttt tgaaagactt tcttgaaaca ccgggtccgc 3179161 gcatatcacg ccaacatttc taagcttttc aaacagccgg cggctgccgc tcgttttcca 3179221 ttcattcagc atacagatgc tgctgtgaag aacgataaag gtatcaagct ccttgcgata 3179281 ctcctccagt ttgttgttct cctgtaaaaa cgccgcattc gtctcataca gcgcaagtcc 3179341 tgattcaaac aattttttct gatagcgctg cacaatggag gaaaggtgaa ttcgataatg 3179401 atagagcggc gtttttacgt aggatactga gcgggcgaaa aaatgagccc tgaagctgaa 3179461 aaactgatcc tcgacatgct ccagctcgcc tcggagcgga aacgacagcc gatgggcttc 3179521 aatcatgctt cttctgtaca gtttgttcca tgaaaaccct ctgaccttcc cttcgaataa 3179581 cgccttgata tagtgctcct tcggctgatc ctgataggtt tgggcaatgt cagagtccat 3179641 ggttttgcca gtgtcctcaa actctgcggc gtaattgcaa atgaccagat cagtttcatc 3179701 gcctgctgtc cggagcatct gctcgcaata atcaggctca atccaatcgt ctgaatcgat 3179761 aaacgcgata aattcgccgc gtgcagcttc aatgccttta ttccgaaccg caccgagtcc 3179821 ctggttttcc tgatgaatca ccttgaacct gttgtccatt ttggcgtatt cttctgcgat 3179881 atccgggctg gcgtcagctg aaccgtcatt gacaatgatg atttcaatat tgtccattgt 3179941 ctggttccgc agtgattcga gacacgttct gatatatgtt tctgtgttat aaacagcgac 3180001 taacagacta accgcaggtg tttccataat gaccggctcc tcgtgcataa attaccggga 3180061 aaaaatcgtt ctgtaaggca gaaccgatga atcgaccggc ataagcaaat aactgtaaag 3180121 aaaataacaa acaacgatag cgatatagat aagagcgttc gatttttcat caaatatcct 3180181 gacgaaataa gggactagga tcatttgata cagaccgaaa taaatattga atctggcaaa 3180241 aatcacgtcc tttgtggcca aaaggccgaa caaaaaacct agcaggcaca aattgacgac 3180301 aatatcaatt tgcggccaca gactccgcag tcgttcttta tagcaaaatg caaggaacag 3180361 cggcagaacc aaaacagcga ttttgatcac attcattcca tttgtgttcg tcatgagcca 3180421 tttttcataa tggctgtatg agctgttttc aagtacaacg acaaacacag aaataaattt 3180481 ttgatataaa aatgtcatgc cgagaaataa agcggatagg ccgaatatcg ccggtgacca 3180541 ggcttttctt ctgacaataa agtacactgg aatcataatc agcgccgacg aatgaaagag 3180601 cgagctgacc agcacaatca ggaaatatcg cttccagttc ccgctaatga tataacggat 3180661 cgcccaaaac aaaacagctg ccaccatgta ttgcctgatg ccgttaaaag atgcgtaata 3180721 atgaaaggtt cccaaaaata aaaagacact cagctcaaac ggcctgccat agtcggcgag 3180781 tgtcttcata ataaagctgt aggtcacgac cgccaccgta aaatacatga tttgaggatc 3180841 ttccgtgatg aaattcatca gccaaaggag tgcggtaaac cccggatctg tcgctgtttt 3180901 cgctgtgccg aaaccgaata tctgccacac attttgataa tcgcccgcca attcgtacaa 3180961 cagcgtgtac gtctgaaaat ccgtgccgac tcgatagcgg agacctgaca cgagcacaag 3181021 tgaagcgagc ggaatccaga tcaaaagctt attcggccga taccccgtgg caagcgaatc 3181081 atcacggccg ccgcacattt tagcgaacca agaccaaata aatacaatcc ccatattgac 3181141 ggcatataca atcatcggtt atggtccttt tccgtgctga tgttgtatac attcagcagc 3181201 gctcctacat tttgctgtgc atcgtagcca agttgagcga gtgtttcttt gatgaactca 3181261 cgcttcggcc tgcctgcggc ggccgccctt gcaatggttt cagcccagac gctgatcggc 3181321 tcagaaagac ttaatcttgt gacaagcccg agaccggcgt cgactttttc tgtaatgctg 3181381 tctgaaatga tgcatggaag ccccgacgcc tgcgcttcca caagcacaac cggcaagcct 3181441 tcgtacagag acggcatgac aaatacatcg aatgttcgca tcagttcatg gatccgttct 3181501 tccgtgccta aaaagaggac gtctgatagc aaattctgct gccgcgcctc ctcctctatc 3181561 tccccgcaca acggcccgtc tcccgccaga acgagctgaa agcgaatgcc tctttccttg 3181621 agatgtgcgg caagcttcaa caggaacgcg tggtttttca cttcatgaaa ccgggccaca 3181681 tggccaatga tgagccggtc ggctgcaatg ccgcgtgctg ctttttcttc atcagccgcc 3181741 tgcccatttg gggcgaacaa ctcaaggtca atcccgttag gaagaaggtg aacacgctcc 3181801 cgctccatat tggactgtcc aaataaaaac ctgcccgcat cctctccgca ggcacacagc 3181861 gctgtcgcat ttgccaaaat gagccgcctg aacacgagca gctgcaatcg atccttccag 3181921 ttgaagccgg tcttccaaga cgtattgtgg gagtggcata ccctgaccgg cactccggcg 3181981 agccttgccg caagggcgat aaaacccgtt tggaaatccg tgtgcgcatg aacggcgctg 3182041 aacggcccat tttcttttat cgcgtttctc acattcctca caaatgtaag gggattgctt 3182101 tgcccaatgc tcgggacata aaaaagccgc ccgcctaaag ataaaatctc ttcatcataa 3182161 gcgcacggat catttcgata cgttaaaaaa tcaaattgca ctttgctttt gtccatcttc 3182221 cgatataaat tcattaccat ggtttccgcg ccgcccctgt tcatgccgct gagaacatgg 3182281 agcacgcgct tttggctgct attcatgctt gacaagccct tccttttggt tcatcactct 3182341 ttttttatgg tagcgattca tcacagctgc aggcataaag gcgcgaatta acggttttgc 3182401 gatatatatg taatcagata aaggaagctt caagcgtctg cacgcctgat agacaagaat 3182461 ggcattgtcg attgaatacg taaatgaccg ccgtttgaat gcatcgctgt cttccctcac 3182521 tttatacaag gcttcctgaa gattatagcc cctgaagccc tcttcaaaaa agcgaagcca 3182581 caaatcaata tcttccattc gtctcgtccg ccgcaccgac cggtagcctt tcagcgtgcg 3182641 gtaggcactc gctctcatca taatcgtgcc gtggcaaaat ggagtccctt ttgccatgat 3182701 gcccggctcc ggaacagaag gcagaatgcg ggcgcctctt acgccaaatt catcaaacac 3182761 aagcatgccg gtgccaacca cctgatagtg tcggtgcttt tctaaaaacg cgacctgctt 3182821 ttccagacgg cgcggaaacg aaaggtcatc tccgtcctga cgtgcgatat aatcgcctgt 3182881 cgcatgcgaa agacaatgat ttaatgatgc ggcaagccgc ttatttgttt tgttttgaat 3182941 cagtttgatg cggtcgctgt aatgagcggc atactgcttc gcgatacgga gcgtgccgtc 3183001 tgttgacgca tcatcgcaca aaatcagctc ccaattttta taggattggc tgagtatgga 3183061 ttctatgctt tctgccaaag tgcgttcgca attataaatg cccataatga cagaaacttt 3183121 cggtcctgag ttcatacgct tttctccttt gtatccatat ccatgtacgc ggaataaata 3183181 tctgccattt cttccaccgt tcgcgcctcc gagaagcgca aggctgtttt tcggccttcc 3183241 tgtcccagct ttcggcagag ctccggctta tggtaaagct gttcaatccg gcgggcaaaa 3183301 gcagcactgt caccgatttt gatcagaaaa ccgttttctc cgtcgcggat gatttcccga 3183361 tgcccgcgat tatctgtggc gatcgccggt tgttctgccg ccattccctc aagcacattc 3183421 ataccgaggc cttctctaat gctggatgcg acagatacat ccgcaagctg aatcaactca 3183481 tgtatgtcgc tgcaaaagcc gtaaaaacag acatgggcgg aggcaccaag cttttcagct 3183541 aacgtttgat acgtatgttc cattgcccct tccccggcaa acacaaggcg gagtgaggga 3183601 attttttctt ttagcaaggc tgcggcttca attaactgct tctggttttt gttcagattg 3183661 agctcagccg gataaaccaa tataaaatca tcttcacgga acccgtgctt ttctctgagt 3183721 ctttgctgct ctatcggact gacaggccgg aaacgctcgg tattgacgcc aatgccgtga 3183781 attttctgcg tccttccgcc cggcctttga agtcctttcg cccgtatgta atcctcttca 3183841 ttaatcgtaa tcaggcagtc tgtatatgct gaaagccatt tctcaaccgg atagtaaaga 3183901 agccaatttt tcatcggtgc ccctttgcag aagtgaaatc cgtgcgctgt gtacagcacc 3183961 tttgttccgt gccgccgtgc ctgcctcgcc gccagtctgg cgagaacgcc gccgaccggt 3184021 gtatggcaat ggacaatgtc gtattcataa gtgtcaatca ctttcttcag ctgcctataa 3184081 acggccaggt tctgagggtc aaaaggtgac ctgcgaatcg ggatggagaa tttctcatcc 3184141 acatacggca gcttggtttg tccgttcgcg gcgacatgaa cctcccagcc catttgcttg 3184201 aaccatttaa aataagggag gtgaaaggcc ttaaaatgat aatcaacagt cgcgcaaaac 3184261 aatatctttt tcgtcatttt cactccccct aatgaacgct ggcagccgtc atttcttctg 3184321 atgtattgat tgccgcaaac agcctcgctc tcaggtcggc ttccggcagc tcatgaaaat 3184381 cctcgataaa gcgcatcagc accggccaat cgccgtccac cgctttaccg atgtgaattt 3184441 ttggaaagat ttgttcagca tggacttcat ttttgttcag caattcttca tacatttttt 3184501 cgcccggacg aatgcctgtg aattcgattg gaacctgctc agtcgtgtag ccggacaaat 3184561 gaatgaggtt tttggcaaga tccacaatct ttacgggctc tcccatatcg agaacgaaaa 3184621 tttgacgccc tttcgccagt gccccagcct gaatcacaag ccttgatgcc tcgggaatcg 3184681 tcatgaaata gcgggtcatt gccggatgtg ttactgtcac cgggccgcct ttttcaatct 3184741 gttttttgaa aattggaatg acgctgccgc ggctcccgag tacattgccg aagcgaacag 3184801 caacaaattt ggttctgctg actttcccaa gattcataat aatcatctct gcgaatcgtt 3184861 ttgtcgcccc cattacgttg gctgggttca ccgctttgtc cgatgaaatc agcacgaatg 3184921 tctcagttcc cgacatatcg gctgcttccg cgacattttt tgttccgata atattgtttt 3184981 tgaccgcctc ttctggattg tgttccatta aaggcacatg cttatgggca gctgcatgat 3185041 agacaacatg cggctcgtat tttttcatca aggtaaacat tttatcgcgg tcctgcacat 3185101 cagcgatttc cgtatggaac acaatgtgtt tgccgaatcg tccgttcagc tctgtataaa 3185161 tcgaatgaat gctgttttcc ccatggccga gcagaatgat ttccttaggc tgaaacgcgc 3185221 tgatctgacg gcagatttcc gagccgattg atccgcccgc tcccgtgacg agaactgttt 3185281 ttcctttgat gcggttcgaa atttcgctag tgtcgagggt taccggcttt ctgccgagca 3185341 agtcctcagc ttttacatct ctgatttgtc cggcagttcg tgtgccaagc agcatttcat 3185401 caaaatgagg cataatttta atgcttactc cggttcgcac acattcttta tataacacct 3185461 gaagctcatg ggtgcggagt gaaggaatgg caataataat ataattaatt ttgagctttt 3185521 gcaccgcagg catgatactt tcttttccgc cgattacggg cagccccata atttctaatt 3185581 tatgcttcgt ttggtcgtca tcaataaaag cgacaggtat gatatcaggt tcatctttcg 3185641 aaagcagctg cctgaccatc agagtcccac ctgagcccgc cccgataatc agcgcgcggg 3185701 acgaggcgca gcgttttttc ctgatgcttt cgtttaatac tctggataaa atacgggtcc 3185761 ctccaataga caaaagctga agcacccagc acgcggttaa cagacggaag aacatcgtgt 3185821 gatacacagc atactgaatg acgccggtca cagcggctga aagcgtaatg cccttaagca 3185881 ggacaatcag ctcgccaagc ccggtgtatg tccacacctg tttatactga ttgaacagga 3185941 aagcacacac atgatagctg aggagcaagc tgacagcggt aagcagtaat gctccggagt 3186001 cataaaattg ataggaatct tttaaaaatt gatatcctgc aataactgaa tttaaaacga 3186061 ggtaagtatc cagcgcaata atcattgaca gtcttctccg gtaactcaac cttttccccc 3186121 ctaattcttt tatcggttta gctgcggcgg ttttcgtctc tccaaaaaat cggcagcagc 3186181 taaaccgaca atacgtccta tgtatatatg agataagtgg gcatttaacc catcctcacg 3186241 ccccgccagc gacgaccagc atctaaggca gcaacttcag ctgcccacag cagagccgag 3186301 tgcctccatt gatacaggtc aggagacatc acctttacaa aaactagtag gaatagtgtt 3186361 ccgatttttt cattttcttt ttgtttaaaa gagcgcctaa cagcttcgca ttggattgtt 3186421 ccagtgcatc ttttgctttc agaacggtat cggtttttgt ttttccgctt aaaacgacga 3186481 gcacgctgcc gtctgtctga tttgctagaa tctgagcatc tgcaacagcc aaaagaggag 3186541 gggaatcaaa gatgacgagg ctgaattgtt catagatctc agatattaaa tctcccattg 3186601 cttttgaaga caacagttct gccgggtttg gcggggtcgg cccgcttgtc agtacatata 3186661 agttatcgat cggcgtcttt tgcaccgtct cactgagtga agcattgccg accagcacat 3186721 ttgtcagccc ggttacatta tcaacctgaa acgtctgatt gatggtcggc tttcttaaat 3186781 cggcatccac cagcagtact ttcttttcct gctgctgcgc aaagacagcc gcaagattcg 3186841 ctgcactgaa cgatttacct tcaccaggca cagaggaggt gacgaggata gatcgcaagt 3186901 tggtctggac agatgagaac tcaatgtttg tccgaatggt gcgatattgt tccgcaacaa 3186961 ctgatttatt gtgtaaaaca gatatttgag ccaaacctcg ccttgctttc ttttttctaa 3187021 agatcactcg cttcactccc cgaaatgttt tatcccgcga ttccgccctt tgtggacatc 3187081 aggaacggag cctaagcatg gcaatccggt tctctcgctg agctgccgtg cgcttttgca 3187141 tgtatcatcg agaaaatgca gaaaaaatgc cagtgtaatg ccgcccatga cagcagcgcc 3187201 aaaagccatg accatatttc gcagcctggc cggcttgatc atcgggcttt ccgaagcctt 3187261 cgcctctgat aatatatgta cgccttgtac attcattctt tcatctactt ctttttcaaa 3187321 cttgttcact aacgtgttcg caatctcagc tgctttcgcc ggatcgtgat cctgaacggc 3187381 aacgttgatt atttctgatt cattttcact gctggtaacc acttttcctt tcagcgagga 3187441 agccgattca gataggtgca attccgcctt aacttcttcc atcaaggcag tgcttttcat 3187501 aatcgattgg aacgtgctgc tatactgaag atttcgctgg atgtcactga gattcgagtt 3187561 ttcttcaccg tctgattcat gaaccagcac ctgtgtcgac gcctggtagg tcggtgaaat 3187621 gaccttaaat tgcacaaaac ccataataag ggtgacgccg attgtgatga gcagaatcag 3187681 cacgaatctg tgtctgacaa tcgcatataa ttctttgaaa ctcatattct cattcatgta 3187741 ttcatagcct tcagccttcc cgcggctggc ttcccgcgcc cctttctgtt aatgattgga 3187801 ttataaaaga aaacgttatt atttaaaaat tgcaaaataa gccaataagt tctctttaga 3187861 gaacaaaatc atgattttcc tctaatttac tgcacttccc ttattatttt aaattttata 3187921 aagaacgaaa aattccttat aatgaacgaa ataacgacag gaatagagga gaatttcata 3187981 ttatgattgg aagaattatc cgtttgtacc gtaaaagaaa aggctattct attaatcagc 3188041 tggctgttga gtcaggcgta tccaaatcct atttaagcaa gattgaaaga ggcgttcaca 3188101 cgaatccgtc cgttcaattt ttaaaaaaag tttctgccac actggaagtt gaattaacag 3188161 aattatttga cgcagaaaca atgatgtatg aaaaaatcag cggcggtgaa gaagaatggc 3188221 gcgtacattt agtgcaagcc gtacaagccg ggatggaaaa ggaagaattg ttcactttta 3188281 cgaacagact caagaaagaa cagcctgaaa ctgcctctta ccgcaaccgc aaactgacgg 3188341 aatccaatat agaagaatgg aaagcgctga tggcggaggc aagagaaatc ggcttgtctg 3188401 tccatgaagt caaatccttt ttaaaaacaa agggaagatg atgatcggtt aaagggctaa 3188461 cgttcgcatc tataggggaa atctgtttat aatgggggaa aaagggagag aacacaatga 3188521 ctcatcaaat agtaacgact caatacggca aagtaaaagg cacaacggaa aacggcgtac 3188581 ataagtggaa aggcatcccc tatgccaagc cgcctgtcgg acaatggcgt tttaaagcac 3188641 ctgagccgcc tgaagtgtgg gaagatgtgc ttgatgccac agcgtacggc tctatttgcc 3188701 cgcagccgtc tgatttgctg tcactttcgt atactgagct gccccgccag tccgaggatt 3188761 gcttgtatgt caatgtattt gcgcctgaca ccccaagtaa aaatcttcct gtcatggtgt 3188821 ggattcacgg aggcgctttt tatctaggag cgggcagtga gccattgtat gacggatcaa 3188881 aacttgcggc acagggagaa gtcattgtcg ttacattgaa ctatcggctg gggccgtttg 3188941 gctttttgca cttgtcttca tttaatgagg cgtattctga taaccttggg cttttagacc 3189001 aagccgccgc gctgaaatgg gtgcgagaga atatttcagc gtttggcggt gatcccgata 3189061 acgtaacagt atttggagaa tccgccggcg ggatgagcat tgccgcgctg cttgctatgc 3189121 ctgcggcaaa aggcctgttc cagaaagcaa tcatggaaag cggcgcttct cgaacgatga 3189181 cgaaagaaca agcggcgagc acctcggcag cctttttaca ggtccttggg attaacgagg 3189241 gccaactgga taaattgcat acggtttctg cggaagattt gctaaaagcg gctgatcagc 3189301 ttcggattgc agaaaaagaa aatatctttc agctgttctt ccagcccgcc cttgatccga 3189361 aaacgctgcc tgaagaacca gaaaaagcga tcgcagaagg ggctgcttcc ggtattccgc 3189421 tattaattgg aacaacccgt gatgaaggat atttattttt caccccggat tcagacgttc 3189481 attctcagga aacgcttgat gcagcgctcg agtatttact agggaagccg ctggcagaga 3189541 aagttgccga tttgtatccg cgttctctgg aaagccaaat tcatatgatg actgatttat 3189601 tattttggcg ccctgccgtc gcctatgcat ccgcacagtc tcattacgcc cctgtctgga 3189661 tgtacaggtt cgattggcac ccgaagaagc cgccgtacaa taaagcgttt cacgcattag 3189721 agcttccttt tgtctttgga aatctggacg gattggaacg aatggcaaaa gcggagatta 3189781 cggatgaggt gaaacagctt tctcacacga tacaatcagc gtggatcacg ttcgccaaaa 3189841 caggaaaccc aagcaccgaa gctgtgaatt ggcctgcgta tcatgaagaa acgagagaga 3189901 cgctgatttt agactcagag attacgatcg aaaacgatcc cgaatctgaa aaaaggcaga 3189961 agctattccc ttcaaaagga gaataaatat ggggaaaaca ggatacattg gtgctgccat 3190021 tgttgtggca gcttgtatca ttattttgtc ggccgtggta tgtttacggg acacagtcta 3190081 ttaccagcct atgcgctgga ctggcatcat actgtttttc gcgggaattg tgatggttcc 3190141 cgcatactca gcaaaaagaa aacccggaaa agagaagtaa ttctcttttc cgggttttta 3190201 tgtttattat aatcttcccg cgcgaatatc gtctgtcatt ccctcataag gagccttcga 3190261 aatcacttct tcgttgtcga ctccttcatt tttcagaaat gtaatttccg caaattcagg 3190321 tacaacgtat tttggatacg tttcatattt ttcgcgggat tctttcatca aatcaatgtg 3190381 gtcattttgg tagcaaaccg taatttcagg atgttcatgc acccatttcg ggaagaaaat 3190441 aatgccatgc atgcgttttt catttggcat aaagtttaat gaaacatccg tgccagtcgg 3190501 ctctgtccaa gacactttat atacgccttc tgtcagtttg acaatattca cttcctgatc 3190561 tcgaacccag cgtccggcaa ccattccgct atgaattcta taatcaattg tatggtcgtt 3190621 tttaatataa atctcgtatt cccatccgtt ttcatacgta taaatcatgt ggcttccgat 3190681 aaagttttcc atcttacaca ctctccttag tcttttactg tacttcataa atgtctagta 3190741 gaacgtaatc aggggttctt tctgcggaac cgataaacaa gcggtcatgg agccattgat 3190801 agacttcact gcctgtttca aacgtcggta ccgtacgaaa ataaacatgc tccggttcaa 3190861 taatttcccc ggctgccgct tgttttcgaa acggcttgct gacttgccgt attccattgt 3190921 tttcaatgta aatcagttca tgatctgctg tttcaatcac atacctggca gataaatctg 3190981 ttctgccgtt agcgcgaatc atttgtgaat cggcaccgcc cggcaaaata cgtcccttta 3191041 cttccccggt tattgttccc gaacgaatcg gaatgaatca tctcagtccc aggcttgtct 3191101 caccaatcgt gataggcgga tcaaccttga tttctaaaga ggcgaatggt tttaaaaccg 3191161 gcttcttcac gagaaccacc tcaccttcag aaaaaatcat gtaactattt acatgttcac 3191221 tttaacacca ttgcagttaa ctgtcaaaca ataggaacat aaaaaaacaa ggactgtttg 3191281 aagacagtcc ttgtctgaag ctagctttga taagcaagat atgtgctgac agtgcttttg 3191341 gcaagacagg cagaggaatc tataatcgga atctcacttt gaatatgatc taacaccgca 3191401 tttaaatccg tgcaggctga aatgatgatg tctgcatgct gactgatttc ttcatatagc 3191461 gtctgccaca atgcttgtgt atgctgcata tgatttggct gtttgattgc ggcgataagc 3191521 tggttcacag cctgctgcca atggtccttg tgaataactt cttgtccatt tcccttcaga 3191581 actttttggt agatggcgga ttggatggtt ggctctgttc ctaaaaccac cgcttttttt 3191641 gcgggatgcg gaatctcttt tatcgtttcc tcaacaatat gcaacatagg aactgacaat 3191701 gcctgctgaa tctcttcata gtagacatgc gccgtattac aaggcagcgc aatgaaatcc 3191761 acgcctgttt tctcgagctt taccgctccg tcgataatcg cttttttcat ctcgtcatgg 3191821 tcaattggac gatctgcata gaagggcgtc gggcatgaat agatcatcat gtgcggatag 3191881 tcaatatcgt ttgaagcccc atacagcttc tgacagtaat caatcacctt atcaataaac 3191941 ggcgaggtcg atttcggccc cattccggct aatattccga tcatcaaatt cattcctttc 3192001 tacttcgtac ggaccgcttc ttcctctgag ccatcctcat agaggataaa gcttttcgca 3192061 gcatcctcac ctaatgtaaa ctcgacttca acagacaatg ctcgcagaaa gaaacgggtt 3192121 tccgaggaag gaaataactc cagtctcagc tgtccggcga tctccaaata aagccgttca 3192181 ttctcggttg tcacctgtgc agccgtccca tcctgcaaca ggtagctgcc aacatagcgg 3192241 ctgtatatcg ccgtatcaat tgcttttttc tttttatcag caggacgttc cgggacatca 3192301 tatggctggc caaatagaat atgttccgcc gccttcagaa tcgcttgttc atattcagta 3192361 tcctcttcct tattactcaa atagatcagc gttttacgat gatcgatata tcggatcatc 3192421 atcgtcgaat agccgggcca tcctccgctg tggctgacaa tccgcccttt ttcaggactg 3192481 ttttgcagca cccagccaaa gccataatca attgtttctc cattgttgag gcgcactgga 3192541 gaaaacgcag attccttaga agccttgctg atgaaatcgt cctgatataa agcctgatca 3192601 aatcgaaaca aatcgcttgt gacagagtta accgtcccat ctccctgtat gccatcgaga 3192661 tacacaacat agttcgtttc ctccagctca tcagggagga cgtatgtttc ggaatgtaca 3192721 tcatacacat atccatatgc ataatgatca attcgctcag gcgaaagcct cctgttatac 3192781 actcttgttt cattcatgcc tgccggtaaa aaaatacttg tttttataaa atccgcatag 3192841 ctcatgccag atgctttttc aatgataacc gccagcagca cataccccgt attgctgtac 3192901 atccagcctt cattcggttc aaaataacca gatagcccct cattcatcag catatcgaca 3192961 atatcctgat tcaccgcaat cttgtgtgaa tcccaattgg caaaaaacca tcccatataa 3193021 tcaggaagcc ctgacgtatg gttcaataaa tgccgaatcg ttacgccctg atacggaaaa 3193081 ccgggcagcc agcgatccac tttatcctca tagccaagaa tccccttctc ctccagcaag 3193141 atgattccca atgctgtaaa aggctttgac aaagacgcta actcaaacaa agagttggtt 3193201 ttcaacgggc gtttttccgt catttccgca tagccaaaag agtggtgata taaaatatcg 3193261 ccaccctccg cagccagaac cgtcccgtta aactgatgtt tttcgcctaa tgtctcaaat 3193321 aacgtctgaa gatgctttct tttattctgc ttcattcctc cacctcccat atctctgtac 3193381 gttactaacc tactaacgtt tcaaatattt tgaaaaatcc ttcagttaga gatccttttt 3193441 aacccatcac atatacctgc cgttcactat tatttagtga aatgagatat tatgatattt 3193501 tctgaattgt gattaaaaag gcaactttat gcccatgcaa cagaaactat aaaaaataca 3193561 gagaatgaaa agaaacagat agatttttta gttctttagg cccgtagtct gcaaatcctt 3193621 ttatgatttt ctatcaaaca aaagaggaaa atagaccagt tgcaatccaa acgagagtct 3193681 aatagaatga ggtcgaaaag taaatcgcgc gggtttgtta ctgataaagc aggcaagacc 3193741 taaaatgtgt aaagggcaaa gtgtatactt tggcgtcacc ccttacatat tttaggtctt 3193801 tttttattgt gcgtaactaa cttgccatct tcaaacagga gggctggaag aagcagaccg 3193861 ctaacacagt acataaaaaa ggagacatga acgatgaaca tcaaaaagtt tgcaaaacaa 3193921 gcaacagtat taacctttac taccgcactg ctggcaggag gcgcaactca agcgtttgcg 3193981 aaagaaacga accaaaagcc atataaggaa acatacggca tttcccatat tacacgccat 3194041 gatatgctgc aaatccctga acagcaaaaa aatgaaaaat atcaagttcc tgaattcgat 3194101 tcgtccacaa ttaaaaatat ctcttctgca aaaggcctgg acgtttggga cagctggcca 3194161 ttacaaaacg ctgacggcac tgtcgcaaac tatcacggct accacatcgt ctttgcatta 3194221 gccggagatc ctaaaaatgc ggatgacaca tcgatttaca tgttctatca aaaagtcggc 3194281 gaaacttcta ttgacagctg gaaaaacgct ggccgcgtct ttaaagacag cgacaaattc 3194341 gatgcaaatg attctatcct aaaagaccaa acacaagaat ggtcaggttc agccacattt 3194401 acatctgacg gaaaaatccg tttattctac actgatttct ccggtaaaca ttacggcaaa 3194461 caaacactga caactgcaca agttaacgta tcagcatcag acagctcttt gaacatcaac 3194521 ggtgtagagg attataaatc aatctttgac ggtgacggaa aaacgtatca aaatgtacag 3194581 cagttcatcg atgaaggcaa ctacagctca ggcgacaacc atacgctgag agatcctcac 3194641 tacgtagaag ataaaggcca caaatactta gtatttgaag caaacactgg aactgaagat 3194701 ggctaccaag gcgaagaatc tttatttaac aaagcatact atggcaaaag cacatcattc 3194761 ttccgtcaag aaagtcaaaa acttctgcaa agcgataaaa aacgcacggc tgagttagca 3194821 aacggcgctc tcggtatgat tgagctaaac gatgattaca cactgaaaaa agtgatgaaa 3194881 ccgctgattg catctaacac agtaacagat gaaattgaac gcgcgaacgt ctttaaaatg 3194941 aacggcaaat ggtacctgtt cactgactcc cgcggatcaa aaatgacgat tgacggcatt 3195001 acgtctaacg atatttacat gcttggttat gtttctaatt ctttaactgg cccatacaag 3195061 ccgctgaaca aaactggcct tgtgttaaaa atggatcttg atcctaacga tgtaaccttt 3195121 acttactcac acttcgctgt acctcaagcg aaaggaaaca atgtcgtgat tacaagctat 3195181 atgacaaaca gaggattcta cgcagacaaa caatcaacgt ttgcgccaag cttcctgctg 3195241 aacatcaaag gcaagaaaac atctgttgtc aaagacagca tccttgaaca aggacaatta 3195301 acagttaaca aataaaaacg caaaagaaaa tgccgatatc ctattggcat tttcttttat 3195361 ttcttatcaa cataaaggtg aatcccatat gaactatata aaagcaggca aatggctaac 3195421 cgtattccta acctttttag gaatattgct gtttatcgac ttatttccaa aagaagaaca 3195481 tgaccaaaaa acaaaatcaa aacagaagcc ggactaccgg gcggcatatc attttacgac 3195541 gccggataaa tggaaaaatg accctcaaaa accgatctat tttgatggca agtatcatta 3195601 tttctatcta tataaccggg attacccaaa aggcaacggc acagaatggc gccatgccgt 3195661 ctcagaggat ttggtgcact ggaccgatga aggcgtggcg attccgaaat atacaaaccc 3195721 ggacggtgat atttggaccg gttccgtcgt ggtggataaa gagaacacag ccggcttcgg 3195781 gaaaaatgcg cttgtcgcga ttgtgacaca gccctcagcc aaagacaaaa aacaggaaca 3195841 atatttgtgg tacagcacag ataagggaaa atcattcaaa ttctacagtg gcaaccccgt 3195901 tatgcctaat ccgggcacag acgatttcag agatccgaaa gtcatatggg atgaccaaga 3195961 taacaaatgg gtcatggtca tggctgaagg atcaaaaatc ggcttttatg aatccgataa 3196021 tcttaaggac tggcattaca caagcggatt cttcccagaa caggcgggaa tggtggaatg 3196081 tcccgacctc tacatgatgc gggcaagcga cggaacgaat aagtgggttc tcggtgccag 3196141 cgcgaatggc aaaccgtggg gcaaaccaaa tacgtacgcc tactggaccg gaagcttcga 3196201 cggaaaagaa ttcaaagcgg atcagactga agcccaatgg cttgactatg gcttcgactg 3196261 gtatggcggt gtgacgttcg aagacagcaa aagcacagat ccattagaaa agcggtatgc 3196321 gcttgcctgg atgaacaatt gggattatgc caacaacacc ccgacaatga agaacggctt 3196381 taacggcaca gattctgtca tacgcgaact ccggctgaag gagcaggatg gaacatacag 3196441 cctcgtctca cagccgattg aagctttgga gcagctgact gtttcaactg acgaaataga 3196501 ggatcaggat gtgaacggat caaaaacatt gtcgataaca ggtgatacgt accagcttga 3196561 tacggatctt tcttggtcag agctaaagaa tgcaggcgtc aggctcagag aatcagaaga 3196621 ccaaaaacgc catattgatg tcggcatttt cgctgaaggc ggctatgctt atgtcaatag 3196681 agcagccaca aatcagcctg acaaaagcaa tacctatgtc gaaagcaaag ctccttatga 3196741 tgtaaacaaa cgtaaggtgc atttgaaaat acttgtcgat aaaacaacga tagaagtatt 3196801 tgttggcgac gggaaaaccg ttttttcaaa tgaagtcttc ccaaagcctg aagataaagg 3196861 aattaccctt tattctgacg gcggcacagc ctccttcaaa aatataacag tgaaacactt 3196921 tgattcgatt catgaataaa aacaggggcg gcgcaggctg cccctgtttt tttattagga 3196981 gcggtattct ctgttacata ttgggcattg taaggaatat aaggctggtt tcaaaggagg 3197041 aagcgaatgt ctaaacaagg aaattttcaa aaatcaatgt cgctgtttga tctgattttg 3197101 attgggatgg gagccatctt tggatcagcg tggctgttcg ctgtcagtaa tgtcgcttca 3197161 aaagcagggc cctccggcgc tttttcctgg atcctcggag gagccattat tttgttaatc 3197221 gggcttgtat atgcggagct cggagccgct ctgccccgta ccggaggcat cattcgatac 3197281 cccgtttatt cacatggcca ccttgtcggc tacttaattt cgtttgtcac gattgtcgct 3197341 tatacaagct tgatttcaat tgaagtgaca gctgtgcgcc agtatgtggc ctattggttt 3197401 cccggcctga ccattaaagg gtctgattcg cctaccattt ccggctggat cttgcagttt 3197461 gccctattat gcttgttttt cctgctgaat tattggagcg tcaaaacctt cgctaaggcg 3197521 aatttcatca tatcgatttt taaatatatt gtgccgatta ccatcattat tgtgctgatc 3197581 tttcattttc agccggagaa tttatccgtt caaggatttg caccgtttgg atttacaggt 3197641 attcaggctg ccatctcgac aggcggcgtc atgtttgcgt atctcggcct gcatccgatt 3197701 gtatctgtag caggtgaagt ccaaaatcca aaacgcaata tcccgatcgc tttaatcatt 3197761 tgcatcatcg tttcaaccat catttatact gttttgcagg tcacctttat tggtgcaatc 3197821 ccgacagaaa cactgaaaca tggctggccg gcaattggcc gggagttctc attgccgttt 3197881 aaggatattg cggtcatgct cgggttaggc tggcttgcaa cgcttgtcat tttagacgcc 3197941 attctgtctc ccggaggaaa cgggaatatc tttatgaata cgacatcccg ccttgtttac 3198001 gcctgggcgc gtaacggcac attatttggc atattctcaa aggtcaataa agatacgggg 3198061 acaccccgcg cttcgctttg gctttcgttt gccctgtcca ttttctggac acttcccttt 3198121 ccttcgtgga acgcgctcgt caatgtctgt tcagtcgcgc tcattctttc atatgcgatt 3198181 gcacccattt cttcagctgc gctgagggtc aacgcgaagg acttaaacag gccgttttat 3198241 ttaaagggaa tgagcattat cgggccgctt tcctttatat ttacagcgtt tatcgtgtac 3198301 tggtcaggat ggaaaacagt ctcctggctg ctcggttcac aactcgtgat gtttttgatc 3198361 tatctctgtt tcagcaaata tacgcctaaa gaagatgtca gccttgctca gcagctgaaa 3198421 tcagcctggt ggcttatcgg gttttatatt atgatgctga tcttttccta catcggttct 3198481 ttcggacatg gtttagggat tatcagcaat cccgtcgacc tcattttagt cgcgatcggc 3198541 tcacttgcga tttattactg ggcaaagtat accgggctcc caaaagccgc cattgattat 3198601 gataaataaa gaagcaagag gttttcttgc ttctttattc tttacaaaca aacatacacg 3198661 cgataaaatg aatgagagtc agtcattact ggaggtgttc ctcatgccaa aacaaacatc 3198721 gggtaaatac gaaaaaatat tgcaggcggc catagaagtc atttctgaaa aaggcctcga 3198781 caaagcttct atttctgata ttgtcaaaaa ggccggcact gcccaaggaa cattctattt 3198841 gtatttttca tctaaaaatg ccctcatacc ggccattgca gaaaatctcc tcacccatac 3198901 acttgatcaa atcaaaggta ggctccatgg ggacgaggat ttttggaccg ttttagatat 3198961 attaattgat gagacatttc tcattacaga acgccataag gatattattg tcctctgtta 3199021 ttccgggctt gcgatcgacc actccatgga aaaatgggag acgatctatc agccttatta 3199081 ttcctggctt gaaaaaatca tcaacaaggc cattgcaaac catgaggtaa cggaaggaat 3199141 caattcaaaa tggacggcca gaacgattat caacttggtc gagaatactg cggaacgatt 3199201 ctatatcgga tttgaacaag atgaaaatgt tgaagtgtat aaaaaggaaa ttttcacttt 3199261 cttaaaacgg agcttaggta ctgcttaaaa aatgactggg taacaccgct cattttttaa 3199321 tgccctaaaa atgactgacg ttcattcata aaatagagag gtgtttcatt tgaattgggt 3199381 tcttgttttt attgcagggc ttttagaggt tgtttgggcc tcttccctca aacatgccga 3199441 ttcgcttttg gattggatca tcatttttat cttaatcgcg gtcagcttta tcctgttgat 3199501 ccgctcttat caaaaaatcc cgatggccgc ggcgtacact gtgtttgtgg gaatcggaac 3199561 cgtcggaaca tatctgactg gaattgttct gggcgaatcc ttctcagcag cccaaatgtt 3199621 ctttttagct ttattgctgg ctggcatttt aggaatgaaa ttatttacga aagaaagcaa 3199681 atctcagccg ggaggtgaaa aataatggca tggtttttat tagtgattgc cggcatagaa 3199741 gaaattatag ctgccattgc catgaaatat atagacggaa caagaaaaaa atggccgatc 3199801 attgtgatga ctgttggatt cggcttatcc ttttactgcc tgtcccaagc gatgatcgtc 3199861 ctgcctgccg gagtcgcata tgccgtctgg actggcattg gaagcattgg tgtttcggcg 3199921 gtcgggctca tctggtttaa ggagcggttt cagctttcac aggtgatttc actttgcctt 3199981 atcctagccg gcgtcatcgg cctgcgtctt acgtcatctt cataaaatca aggcatatac 3200041 agctgtatat gcctttgcca ttaagcttcg tgatgttttt gaagatgaag cggcggcggg 3200101 atgagccagc ctttgttttt tagcagcctt aagtattttg cgccggttgc cgctttcgac 3200161 atatgaaatt gcccaaacat catggcaata tcctcacgaa tcgattgccc catcattttg 3200221 ctgcatgtca caagacctgc agcattttct gctgccgcgg aagccgccac atccggatcg 3200281 agaaaccgtg caccaggcgg aatatcgtta agatctgctg tcggcggttc aggagaagcc 3200341 ggcggcagcg ccaccccgtt ttctttcagg atcgtgctga cctgtttgat ttcatcttgg 3200401 catttctcaa tagactcacg aagcagcttc ttcaggtcgt catcaccgac atgattcaat 3200461 agcatttggt aattgccgac cattttattg cccgccatca cataactcca caagccgaat 3200521 acctcaccgt aatgcatcgg ttcatcctgc ggatttccgc ttaaaatacc catgctcatt 3200581 ctcctcccat attcaatatt gcacatttca taacgtgccc aagcggagga acatttatgt 3200641 ttcagcggaa aagatttatg aaatgaaaca aaacaaaaaa gacaagagtg gcaagttgcc 3200701 aaaccattgt ctttcctgtt gtttgattgg acgcactgaa gggattcgca ccccgacaga 3200761 caagataccg gaaaccattc aagtgctttt tagtatgagt cattgattct gtctttaata 3200821 aactttaacg agatggcggg atgctttgcg gaaaacgaaa tacattttcg gggtcatatt 3200881 tcgcctttat ttctcgaagc cgcgcaaagt ttgcgccata atattctttt ccgaagtttt 3200941 caatgttttg atctggaaca ttaacatatg aacctgctac atatggttgc atcagctgac 3201001 gcactctttc aactgatgca agatttgaat cttcttgtga tttatttttc caactagccg 3201061 tccattccgt ataaaataat ggatggcgcc aaaaaaaggc agtttcgtct ttagggactc 3201121 tgcttatagc accaccccaa ttgataaaaa agaaattggc ttctgttcca gtagcatctt 3201181 ccaaaaattt tctcatgatt gaaatgggtt cgtcagacca aaaatcatga ccccatgccg 3201241 aggagaattt aacactctga tcatttctgc cagggatggg ttcgtcaggg tctaagaaat 3201301 ctatagcatc tggatagtat aatgttttga tatctgcttc tgttggagtt cccgcatgta 3201361 ataaaggttt taataatcga atcaattcag ttttcgaacc gaggaaaatt ccttctgcat 3201421 gacacaaacc atttattttg ctgtaaattt caaggtagca tcctaatcgt tcatctacaa 3201481 acggagccca tttctgccaa gctttaaata ccgtttctaa ttgttcccac ggccagataa 3201541 tattgaagac ggttgcagtt ttaggggcac gatgaacttt gaatgtatat tgggtattat 3201601 atccaaagtt acctcctcct ccgcctctag aagcccatag caaatcctca ttgtgagatt 3201661 gatctgcgtg aataatcctt ccttttgcat ctaccgtttt cagcgcgaga aggttatcac 3201721 ttataaggcc aatcgatcgt gagagtacac caaatccgcc gcccatcgta attcccccga 3201781 ttccaactgt tgggctatct ccaaacggag ccataaaacc gtctcgagct aatcccttta 3201841 caagcgggcc aacgggaata ccagtttgaa cggttgcaat agcgttttct tcatctaaga 3201901 aaactttatt catgtcactc acatcaataa caattcctcc acttactact gaaaggttct 3201961 tatctaaagc atggcgaccg cttctgacac gtaagggcac tttattctca cgagcccatt 3202021 taatggcatt acttacatcg tatgaatttt gcgcaaaaac aaagacaaga ggatagacat 3202081 ccacataagg gttccaattc ttaatagcct ctgtatagcc ggggtctcct ttgaagatta 3202141 cacgccctgt caactgtgtt gatcccatat attatttcac tcccaaagaa attcgattca 3202201 gatactaaaa tatgcaggag ctggataatc gcatagacaa atgatctacg aactataaat 3202261 ataatacgct aaggcctttt tcgtcggtga ggtctgctga gaaacatttt tcaaacaatt 3202321 ttgagcaaac ttcctgtcca atcctccaac aagcgttttt tcttatcgtt tttaggagca 3202381 gtgtccagtt tttttcggag tgaatattcg tttaggccaa aagaaaagag agatgaagaa 3202441 gtgtttagta ccagaggtat acatccatac aacagactct agatcatcat atactgaatg 3202501 tatgtagaaa ggagacatca gctttggcaa aatatcggat tatgaccttt gacggcggcg 3202561 gtaccttagg tgctttaagt ttacaactat taaacagatt ggctaggcaa aacccgaagt 3202621 taattagtcg aacccatgta ttttcgggaa attcaatcgg ttcatttact gcccttgcat 3202681 tagcaagcgg aagatctccg agggaaacac ttcagtattt tgaggatgaa atcctacccg 3202741 cattcagcat ttcccggcca ggcggacctg ttttcaacca acaattaccc tattccggtt 3202801 ttattaaagc ggtaagaaat tttttcccag cagatcttca acttatagat ttaagaaaac 3202861 gaattgttgt cccatcattc aaattatact ctcaaaaact ggaccgttgg actcctgtct 3202921 tatttcacaa ttttcccggc tctccctatt taaatgaaaa agtgagtgat gtcatactgc 3202981 ggagcagcgg tgctcccgcg acgcaacgcg cctatcaaaa ctatgtggac ggatatgtag 3203041 tagcaacgaa tcccagtaca gccagtatcg cgtttgcagt tggtaaagcc aacgtgccat 3203101 tggatcaaat tgcggtattg tccatcggaa caggtgaagc cccgactcgg ttaagaagag 3203161 atacgagggg atggggaatg gtaagtgcag ataacatacg tcccgaaaat ctgaagaacc 3203221 ttcctccaaa ttggggagtc cttttggaca ggtcgcctaa tgaaccttta ctgccatttc 3203281 ttcagatgat tgctggcggt aatgggtact atgaatccat ggtcagtgcg aatcttctgg 3203341 gagatcgttt tttccggtta gatccgcgga ttccgaactt ctccaaaacg gaccctgccg 3203401 tcgttcccgc tgtcattgaa attgcgaaca aaacaaactt acagcctgcg aatcaattta 3203461 tagagaagaa ctgggggagc aaataattat ttattttaaa tcaattctcg cttatacaat 3203521 tttgtccgag agaagattct caaaataaat acaggcaatg ggtagaaccg gattttttta 3203581 aaggtttgtt aatcacaagc taataagatg aatgaaaaaa tcaattcata cttcttcttt 3203641 tgaaagtgag ggttcaaact aaagaatgta attgaaatgt tactctaagg tatgcaattc 3203701 cctttttcac acaaaaaaag acaagagcgg caaatcgcca aacccttgtc tttcctgttg 3203761 ttctattgga cgcgctcgga gggattcgaa cccccgacag acgtggtacc ggaaaccacc 3203821 gctctatcca actgagctac gagcgcatat agactgcgtt atgagaacgt cagcacaact 3203881 aattatacga taattccttt caaataacaa ccctctattt cgagaggccg ttttttaaat 3203941 agacaaagca tcttaattgg caatctgaca tacgatggtt tgaacccctg tatttttggg 3204001 gaaaatggga aaaagagacg actttgcata tcaggccagc tttttgtttg acctttattg 3204061 accaaaaatg tatcatgtaa ctacatactt acctaaaagg tgaaggagga gcattatgaa 3204121 tttaatacct acagtcattg aacaaacgaa ccgcggggaa agagcgtatg acatttattc 3204181 tcgtctatta aaggatcgta tcatcatgct tggatctgcg attgatgaca acgttgcgaa 3204241 ctccatcgtg tcacagcttt tattcttagc agcagaagac cctgaaaaag aaatttctct 3204301 ttacatcaac agcccgggcg gctctattac agccggtatg gcgatctatg ataccatgca 3204361 gtttattaag ccgaaggtat ctacaatttg tatcggtatg gctgcgtcaa tgggcgcgtt 3204421 cctgcttgca gccggcgaaa aaggcaaacg ctatgcgctt ccaaacagtg aagtcatgat 3204481 tcaccagcct cttggcggtg cgcaaggtca agcgacagaa attgaaattg ctgcgaaacg 3204541 cattctcttg cttcgcgaca aattaaacaa agtcctagct gaacgtactg gccagccgct 3204601 tgaagtgatc gaacgcgaca cagaccgtga taacttcaag tctgctgaag aagcgcttga 3204661 atacggcctg attgacaaaa ttttgactca cacagaagac aaaaagtaat aacacaacct 3204721 gcaagagctg cgtctcttgc aggttttttt catttcaagg aattgactcc cttattctat 3204781 actgctccca ttcctcatgt aacagctcaa gcgtcaaatc actcgtctgc ctcacaacca 3204841 gatcagcacc aagcatcggc tgtccttgac cgacaccaac cgcaaacatc cccgcagatt 3204901 tgattgcaga aatgcctgct tctgcgtctt ctattgccgc gcaatcagca ggggaaacat 3204961 cgagcatcgc tgcagctgtt aaaaagatgt caggatcagg cttccccttc gcaagagtcg 3205021 tcggatcaac aatggcatga aaatcatcga taattgccaa gcgtcttaaa atcttaggag 3205081 cattgcgact tgaagatgct aacccgattt ttatattttc gtttttcaat tgacatagaa 3205141 gcctgccaat ccccggtaaa agatcttccg gcgtcaattt gctgatcagc atttgataat 3205201 cgcgattttt ccgatgcata agctcttgtt tctccgcatt tgtatacttt gtttccgccc 3205261 cgccaaagat caatatgctt tcaagtgact cttctctgct gattcctttt agcctttcat 3205321 tcatgtctct gtcaaaaggg atatcgattt gttctgcgat gtgcttccaa gcgagaaaat 3205381 gatattcagc agtatctgtt atcactccgt ctaaatcaaa aatgaccgct ttcatatact 3205441 aatgcccatc acagcttcat aaggtttgag gctaatactc tttaagtcag cccgctcctg 3205501 cggatagttt gaaattagca ctttccaacg ctcatgaatc agttctggag gcgcttcgaa 3205561 cagagccttt tcttccgata aattcacaac gacaagaagc ttttcccctc gatattctcg 3205621 aaggtaagaa aagacctgcg gatcattctc ctgcaacagc tgataatcgc catatatcat 3205681 aatcttatat tgctttcgta attgaatgag cttctgatag taaaagaaaa tcgaatcttg 3205741 atcttccaaa gactctttca cattgatatc ttgatagcgg gaatttaccg gtatccacgg 3205801 gtctccggct gtgaatcccg catgttttcc ggcatcccac tgcatcggtg ttctcgcatg 3205861 atcccttcct tttatcatca cggctttgac aaactctttt tctgacatcg ttttgttttc 3205921 gacgactagt tcacgatatg cattctttat ttcaagatca tcatacatct ccagcggcat 3205981 atcgctgttg accatgccga tttcttctcc ctggtaaata aacggcgttc ctttcatgcc 3206041 gtgcagaacc gttgcaaatg ccttcgcaca ttccttacgc agtttcctgt cattgcccca 3206101 gcgggaaata accctcggct ggtcatggtt ctcaaaataa agggtattcc agccgacatt 3206161 cattaacccg gtctgccacc ttgtcatcgt cttttttaaa gcaatcaaat caaacggctt 3206221 gatctgccat ttcccatttg gcgagttttg ttctttatca atatccatat gttcaaatgt 3206281 aaagatcata ttcagctctt gcctgcttgc atctgtgtac tttttcgcct cttcaatatc 3206341 agagccgttt gcctctccga ctgtcatgca gtcgtaatga gaaagcactt ccctgttcat 3206401 ctcttgaata aactcatgaa gacgtgggcc gttagagtga taacggccga caatatagct 3206461 gcggctgtga tccgtttcgt agtccggaaa atcggtgtat ttagaaatag agccaatcac 3206521 atccatccgc cagccgtcaa cgcctctatc catccagaat ctcattacat cataaacttc 3206581 ccggcgaacg gcttcgtttt cccaatttaa atcaggctgt tttttcgaaa agtagtgcaa 3206641 ataatactgc cctgttcctt catcgtatgt ccacgctgag cctgaaaaga tcgatcccca 3206701 attattcggc tctgagccgt ccggtttagg atctttccaa agataataat cccggtaagg 3206761 attgtccttc gacttgcggc tttcagcaaa ccaagcatgc tcatctgatg tgtggttcac 3206821 gaccaaatcc atgacgattt tcattccgcg tttatggact tcatcaatca gctgaaacat 3206881 atcttcattt gtcccaaact tttcgtacat gtttttgtaa tcgctgatat catatccgtt 3206941 gtcatcctgc ggggaatcaa ataccgggga gagccagatg acatccgccc cgaggttttt 3207001 gatgtaatcc agcttttgaa tcacaccttg caaatctccg aatccatctc cattggcatc 3207061 ataaaaactg cgcgggtaaa tttgataaac gacagcttct ttccaccatt cactcattag 3207121 gcgttctcct ttcacatcgt ccctgtagga caaccggttc ctcataaacg ttcatgtgca 3207181 gcggctcgcc ttttacaagc tcaaaaataa cgcgcttttc gtcaaccgtc acattgatta 3207241 atcgatttcg ataattgatg ttgaatgaat attcgtccca ttctttcggc aaaaacggag 3207301 caaatgacag cgtctcattc gcggtgcgca tgcctgcaaa gccatgaacg attgccagcc 3207361 agctacccgt cattgaagta atatgcaagc cttcttccgt atcatgattg taattatcaa 3207421 gatcaagcct tgctgtgcgc ttatataatt cgagcgcttt cttttccagc ttgagttcgg 3207481 ctgcgagaat cgcatggaca gagggcgata ggcttgattc atgaacagtc atcggctcat 3207541 aaaattcaaa atttcgccgt ttttcttcca ttgtaaaacg gtcattaaaa agataaatgc 3207601 cttggagaac atctgcctgc ttaataaaat tggagcggag aatcttgtcc catgaccaat 3207661 tctggtaaag aggccgttcc gctggatcta attcgtcaac tgtttgcagg tctttgtcca 3207721 agaacgtgtc atgctgaacg aaaatttgca gttcttcact aaatggatag tacatgtgct 3207781 ggatgatttc tctccagact tccaattcta cttcctgcac atccagatgg cggcgtttct 3207841 ccgctgagat actttcgaga ctttgtagag tatactccaa cgtccaagcc gcaatgacat 3207901 tcgtatacca attgttgtta acgttgtttt cgtattcatt cggccctgtg acgccatgga 3207961 tcatatactt attttttcgt ttcgagaagt gaacacggtc ggcccaaaat ctgctgactg 3208021 ccacaagtac gtctatcccg tattcttcca tatagttacg gtcgcctgta taattgatat 3208081 aattgtagat cgcataacag atcgcgccat tgcggtgaat ttcttcaaag gtgatttccc 3208141 attcgttgtg gcattcatca cctgtgaacg tcaccatcgg ataaagtgcc cccttcatcc 3208201 ccaattttgc agcgtttcgt ttggcagcct ccaactgatg atagcgatac aaaagcaggt 3208261 ttttcgtcac ctccggctcg gctgtcgcca aatacatcgg aacggcgtac gcctcagtat 3208321 cccaatatgc ggcacctcca tatttctcgc cagtaaatcc tttcggcccg atattcaaac 3208381 gggcatcgcc cccgtaatat gtcgagaata actgaaagat attgtagcgg attccttgtt 3208441 gaagctcctc atctccttta atctcaatgt ccgcttttgc ccatctttcc ttccatcgat 3208501 cagtgtgcct ccgttttgca tcttcatagc cgttctctac cacatccgcc aaaagctcct 3208561 tggctttcga taaaagctct tcctcccgaa aatcacggga agtcgtgaca atcacaaact 3208621 ttttcaatga tgccttcgtt tgataactgt agcgattctc gacatacatt tcagtcgttt 3208681 taaagctttc atggacaaaa ccctccgtct cgtttgccat tgcggctaat accgtgaagc 3208741 gcggtgttcc aaatggattt tcgatcgttt ttgccgctaa atggccgctg tgagaatcag 3208801 cacctttcgc ttcctcctgc caaaactgtt cttggtagtt agaatcttca tttgccacat 3208861 ttccatccag gtaaggaaca agcgtaatga cagcatctcc cgtcaagcac tccgcttcat 3208921 aatgaatcgc acagagttct tttacagcaa ggctaagaaa ccgctctgac ctgattctga 3208981 cggttttatc ttgaatgcgg acaacagcgc ttcgccgcag aatcccctct ttcatattga 3209041 gttctacctc aaataattcg attgggtttt gatggagatc gattttttca ccgtcaacat 3209101 ataggcctat gcccataaag ttcatcgcat tgatcacttt tccgaaatat tctggatacc 3209161 cgtttttcca ccagcctact cgcgttttgt cggggaacca cacgcctgca atatatgtgc 3209221 cttggtgact gtcgcctgaa tagccttctt caaaattccc tctgaccccc atatagccat 3209281 tggcaagaga cgtcaggctt tccagcagcc gtgtatgctc cttattaaat gtatttgttt 3209341 tgattttcca ttcatcaatc tcaaataacc gctgatttat catcatttcc tcccgaatgt 3209401 aagtttccat tatcacggcg ggttttggtc aaatatctaa atgcaaaaga gatcatcaaa 3209461 gtaacgccac acgaatggat catcaataca gtaatcaaat caaaatgaac catgccgata 3209521 gcagctgccg caaatgccgg cagtgctgat gcgcaaatcg ctatagaggc cgcttccttg 3209581 aatgatgcaa tagagaccat gtttgatatt tttgtgatcc agaggccacc tgcaagaaca 3209641 aacgttaaca aaagctggat catagaaacc accgtatatg ccagcatcat gatcatcggc 3209701 ttatactgtg ccaaccacaa tgtatcgatc aagacctcta catcatggac gtttggtttc 3209761 tcgagcttaa cgtccatttt cgcatagcca acagaaaacc ccgtttcgtt ttgatcggtg 3209821 atcaccagtt gatcaggttg aaatatgatg gcgttttcaa atccagttac tttcaatcgc 3209881 ccattttcac cgcttgtctc atattcatgc ttcatatcga ctgccatcac attctgccca 3209941 tcttcaatcc tctcagagct cttcccgcct gttagttttc cgttcctgat ttgaaaaccc 3210001 tgcaattgat cagcaaattg atcattaact ccttgaatcg ctgacggcat gaaagatgaa 3210061 acgctgaagc gatccatttt cacaaacgaa accgctaacg gcgccattaa gcaggccgtt 3210121 aaaaacagaa agagaaaaga gagctgcagc cagctgaagg tattcccata gcggcaaaca 3210181 cctgatgggg atgcagccgc cttcaggcag cggatgataa agcttttatt ctccagattc 3210241 ttcattggca ttaccccttt gttccgccgg ctgtcaaacc ggacacaaag ttcttttgga 3210301 gaaaaaagaa tagaacgcat atcggcagtg cggctagtat ggcaccggct gcaaatagag 3210361 ctactttttg ctgctgcgga ttagaaataa aggattgtaa tcctacagcg atggtcagcc 3210421 tttccggtga gcgaagcaga aatttcgtca gcaaatagtc gccaaacggt gccataaacg 3210481 cccaaagcgc ttgtaccgcg agcattggct taacaagcgg tagaacaatt gaagcgaaaa 3210541 tcctcagatg tcccgctccg tcaattcgcg cggcttcatc aatttctctc ggcacagtat 3210601 caaaataacc tttcatcagc cacgtgttca tcggaattcc gccgccgata tagatcgctg 3210661 ttaaaaacca gtattgatcg agtgcgccta ttagcatcgc caagacataa aaagcagtca 3210721 gcgccgccat tgtcggcacc atttgaatga ttaaaaagaa tatcaggctc ttttttctgc 3210781 ctgcaaaccg atagcggctg tacgagtacc cggcaagtgt cacaatcgta acctgcaaaa 3210841 ccatgaccga tagcgcgatg acaagtgtat tgctgtacca attgagataa agcgtttcgt 3210901 caaatagccg cttaaaatga tccaatgtcc aagaacccga aaaatcgagc tgaaaagccg 3210961 ccgaattccc cacacggaag gctgatgatg ccgtaatcag caacggatat ataatgacaa 3211021 tacttaaaag cgtcaaaaat aaatacgtac agattttatt aagcattctg gcagtgctcg 3211081 cgttcaccta cataacctcc tcattgccaa aagcattcga ttttttgaaa gcaatcagtg 3211141 aaattccaat gacaatgaaa gaaattaaca gtgtcacagc cgccgcaacg gaatattggg 3211201 gtgatgtgcc tgttgtcagt ttataaatcc acgaaattaa gatatcggtc gatccggccc 3211261 cggctcccgc actgcctggc cctccctcat taaataaata gatgatcgag aaattattga 3211321 aattaaacgt atactgagta atcatcacgg gtgctgtggc aaataaaatc atcgggaatg 3211381 taatatgccg aaaacgctga ataaaagtgg ccccgtcaat ctttgccgct tcatacaatt 3211441 cacctggaat cgcctgaagc actcccgtta ccatgacata tatatatgga aagccgagcc 3211501 acgtttgaat cataatgagg gctgtctttg tccagaaagg atcggtcttc cacgcgatcg 3211561 caggcagctc gacaaacggc aggtgattga ataatggtat cacctgtgca ttcaccgctc 3211621 ctatgctgtc gttaaacatg ttggaaaaac tcatgattgt aataaacgcc ggaacagccc 3211681 atggaaataa gaaaatcatt cgaaatatcc gcttgccttt tataaaatcc tgattgacga 3211741 aaagtgccgt cacaatacct aaaatgattt gcagcgttgt tgcacagatt gtccagataa 3211801 ccgtccagcc cagtacattc acaaatgttt cacgatagga gccaaggaaa aaaatattta 3211861 agaaattttt aaacccgacc cagtcaatca gacgattagg cggaatatga taaaaatcat 3211921 agtttgttaa tgcaacaaac agagtcacca aaaccggaaa aataatcaca aacaccatca 3211981 tgatatatgc cggcagtgta aatagatacg gaaaaccttt atcgcccgca tgacagatca 3212041 tatccttggc tgttgtattg acttccaaac ccgccgcttt catagcggcg gtcttacgtg 3212101 aatcatgaat attaaagata tagaacatga ggaaaatcat tgtcacgatc aattgcagcg 3212161 tgccttcaat cagcataaac agcgagtgat cttcaccggg aacacttccc aatgtcatca 3212221 atccggttag cgcctgtata ccgaaaacgc ataattcaaa agcaaacaag cctgtgatgg 3212281 caagaaataa gagccccttt gacaactgct gattcgcaat ctgcccaagt cctggaatga 3212341 tcgataaaag ccctgccttt cgtttttgct ttgtaagtgt gtgatgttta ttcatttttc 3212401 cgccctctat tcttccggac gctatcccgc cgttttattt cacatacttt tctttaatat 3212461 tttcctttat gacgtttaca gcatcattcg ctgatgtttg tgtcgatttt tttcctgaag 3212521 ctgcatcaaa aattaaactt tccgctcctg tccatacttc agccatttcc ggaatatttg 3212581 gagtcggcgt tgctgtttca tattgtttaa tcacagctga cgtcagttca ttcttttgct 3212641 catcggcttt cttccttgca gccgtgttgg ccggaacttc gtttgtatcc tcataaaaag 3212701 cgtaagcatt ggcatcattt gcagcatact caagccattt ttcagccagc tcgggctctt 3212761 ttgtatattt cgaggcaacc cagcccttcc cgccagcaaa aggggcgtat tcttctccat 3212821 ttggcaatgt cggaatggga gccgctccgt agttcaattt agcctcttta tagttggcag 3212881 ctgaccaagg accgccaatg atcgcagccg ctttgccttc taaaaacatc tgctgaataa 3212941 agtcgtctgc gcttgaattg tcttgcattc ctttcggcca atatgtctca aaccatttct 3213001 ccgcatattt caccgcttct acagcccctt tattgttcag gccgatgtcc ccggaatctg 3213061 tgccgttttt tccaaacaca tatccgccgt atccagccaa taagccgtac gacatataaa 3213121 agtcagtcca ttttgctaaa aatccggttg attttccttt ttccgaagca aacgcgaatc 3213181 gaggatcttc cgttaacttt tcaaggtctt taaatgtttt tggcgctgtt tttaaaagat 3213241 ctttgttgta atacaaaata agtgtctcaa tgactagcgg cattccgtac actttgccgt 3213301 caactgtcac ctgctgcatt tctttatcac caaagctttt tgtgttagat ggcttaatat 3213361 caagtaaatg tccttgttgt cccaaaccgc cgatccggtc atatgcagca agcataacat 3213421 caggcgcatt acccgccggg ccatcaagag gaagcgcttc taactgttcg aacatttgct 3213481 tttcaacaat ttttactgtg acatcatttt ctttttcgaa ctttgttttt atgctttcaa 3213541 tgtattcttt atacgtttct tcgacagaca cagtcagcac ctttttgcca tcagagcttg 3213601 ctggattttt tgaacttgag caggcggcaa ggccgattgc caggaatgat gccgccaata 3213661 tggcgaaccc cttttttaaa agaaccatct cttttcctcc ttctatttac gaaactataa 3213721 caattgtatt gtcctataga aagcggttac aacaactttc gatttgttac cgataacaga 3213781 atgttataca ggggcggcag cactcaaaat caaaaattct cccggctgaa cggcaatgac 3213841 atcgtgatgc tgtagcggct gctctgtcca tgcatcacag attttcttat tcctatcaat 3213901 attcaactct cgtaaactga cgtgttgaac cacattccct tgattaaaga aataaatcag 3213961 tattttttca tcaagagtcc gcgaaaagct aatgaaatca tttttgtcgt ccagcagatt 3214021 ccactcaaga tgtccttcag tcaataaagt gttttcctgc ttgcgtaaag caattaaccg 3214081 tttcataaat tgcagcatgt cttggttttg cttctctttt tcccaaacca tacatttccg 3214141 gcataatgga tcattttcgc cgttcagccc gatttccgtt ccgtaataaa tgcatggtga 3214201 gcctgtctgg gcaaacataa aggccagcaa cgcgcgtgct ttcttctcat cattgcggca 3214261 tctggtcaaa aggcgctttg tatcatggct atccagtaaa ttaaacatca cctcattggc 3214321 ctgcttcatt ccattcatca aatgtgcatt gacacggtga gccatacgtg aagctgagat 3214381 cgtctggtca gcaaagtatt caatcatagg ctctgtaaaa gggtaattca tcgccgcatg 3214441 aaattcatcc cctctaagcc agggttcggc agaatgccag atctcaccta aaatataaac 3214501 atcaggcttt tcagtagata cagcctgcct aaatgtcttc caaaaaacgt gatccacttc 3214561 atttgcgaca tccaaacgcc agccgtcaat gtcaaattcg cgaatccagt acaaagcaat 3214621 atcaagcaaa tatttctgca cctcgggatt agccgtgttt agcttcggca tatcagctgt 3214681 aaaagcaaat ctgtcataat tgtcgtctgt gacgggaaaa gagtgaatat ggaaccagtc 3214741 cttatagcgg gattgatctc cgtttttgac gacatcctgc cattgcggag acgcgcttcc 3214801 tatatggtta aaaaccgcat caagcataat tctcatcccc cgctgatgca gctggctgac 3214861 caatgtacga aaaagctcag gatccccgaa atgcggatca atagaaaagt aatccagcgt 3214921 gtcgtattta tgattagaag gcgcggaaaa gatcggtgtc agataaatgc cgttcacccc 3214981 taaatcctct aaataatcaa gcttgtcaac aattccttgt aaatcccctc caaaaaaatc 3215041 attgacgtcc gggtccttgc tcccccacgg caatgcattc ttcggtgaca agtcttctct 3215101 tccatttgca aaacgctccg gaaaaatttg ataccaaacc gttgacttga cccattcagg 3215161 cgcttgaaat gtatcagcct cgtgaacaaa cggaaattta aagtaataat gaatcgtttc 3215221 cagtgttttt tcgttataag ggcatacacc cgaacttccg aaaaagatgt cttcatgatc 3215281 gtctgttaca acaaacgcat attgtaaacg cctaaatggc ggcaccactt cagcaaacca 3215341 atagtcatgc atttctgtag cagcaatttt cctcatcggc tgctcgtttg ccgaccattt 3215401 gccgtcgttg tactcatagg gatcacccca aatgaatcga atgtgatctg catcaccttt 3215461 tttcgtccga atcttgatat gcacagtccg cccatcataa gaataagcat ctgtgctgaa 3215521 tggctggtga tgaatcgctg catattccat catgtttccc cctttgattt ccgttttatt 3215581 gaagccggct catagtttga aagtatcatg atgaaattgt gggaacaatc cttttcaccc 3215641 tgttaccgat aacagaataa ggcgcttaca gcgttgattc tcgtacaatt aactctggtt 3215701 caaaaaatag acttccttgt gcagcgccgt cttcattcat ttttttcagc aacattttcg 3215761 cacaggcttc ccccatttca acaacaggct gtctgaccgt agtcaagcgc ggcgaggaga 3215821 tgcgatcaag aaacacaccg tcattcccgg taaccgcaac gtcttctgga attcgctttc 3215881 caagggattg cgccgcacga atgacgccga gcgcgattcg atcagatgcg cagacaaatg 3215941 cggcctgatt gtccatggat ttcagcagtt ctcttgcaag gcattcactt ttcttagaac 3216001 tgttgtcgat ccgaaacata ttcgattttt taaagctttt attcatcgcc cgtatatacc 3216061 cctgttctct tgcacgttcg aaaggctcat ctaaatcaat gccaaaaaag acaacttccc 3216121 gctcccccag ccccataaca tggcgggttg ccataaaagt gcctttctcg ttattcacat 3216181 cgataaagtc atagcccatt tcattttgtc caaatacgac gagcggcttc tcaaaagctt 3216241 ttattacacc ttcaaaatcg ttctttctca agccggtggc aataatgccg tcacattggc 3216301 caatattaag agaatttctt gtcacaagct ggagagcata gtgattgcga tccagctccc 3216361 tgctgattcc tgtcagcagg ttcatgtaat atggttctgt cgtatccatt tcctcaagta 3216421 tcaatagttt cacaacctgt gttctgtttt gcacgagcgc tctcgccgca taattaggga 3216481 tgtaattcag ctctttcatc gcagaatgaa caagcttttt caattcatcc gtcaccgtct 3216541 cagggtgatt gatcactcgt gataccgtca ttttcgaaac atttgctttt ttcgccacat 3216601 ctgacaatgt tgccattttc atcccctcct tatctgtgct tattatccaa actagtgata 3216661 aagtcctcta ttactgctaa atatacgatg caggccaaag agaaataaaa aagagatttc 3216721 ccttaaggaa acctcacttt gttaaaaaca ctcgattttt catggattca tacgctaggt 3216781 ggcagactca ttctctccac ttccatcaga aaatctcttt tttaaatttc tgtccacttt 3216841 ttttctaaaa tcggataaga ataattttgc atttgctcaa ttaactcatc cggccgtgac 3216901 gagctgtgaa tcagttttag gtgcgattcg ttagaaaacc cttcttgaat gctgtatttc 3216961 accattttca tcattggttc aaaatatccg tttacattgt acagtccaat tggcttttgg 3217021 tggatgccga tctgtgccca gcacagcact tcaaataatt cttcatatgt accgaagccg 3217081 cccggcatcg agataaagcc gtccgccagc tcgctcattt tagcctttcg ttcatgcatc 3217141 ccgtttactt caatcagctc agtcagattc tgatggacaa cctccccgct gaacaaaccg 3217201 ctcggcatga ccccgattgc agttccgccg ttttccataa tcgcgtcagc aatcgtgccc 3217261 atcaagccta cgcgggagcc cccatagaca aggccgattc cctgctcagc catatacacg 3217321 ccaagctctg ccgcttttct tttatacgct tcatttcccc cagggtttga tcccgcaaat 3217381 acacaaatgg ttttcatctt gtcatctccg catctatata tcgtgttaaa cattcaaaaa 3217441 cacactatat attgtcccat cttcatgtga taatatcaat atgaaataca taaagaatgc 3217501 aggagtgatg aggttgcagc tggctgatgc agaaaaatgg atgaaagagt tttacgaaaa 3217561 aagaggctgg acagaatacg gaccttttat tcgcgtcggc tttttaatgg aggaagccgg 3217621 agaactggcc cgggctgtca gggcgtatga aatcggcaga gaccggccgg atgagaaaga 3217681 atcgtcacgc gctgagcaaa aacaagaatt gattgaagaa atgggagatg tcatcggaaa 3217741 tatcgccatt cttgctgata tgtatggtgt ctctttagaa gacgtcatga aggcccacca 3217801 agaaaaactg acaaaacgat ttgagcatgc ataaaaaagc ggccgcgatg gccgcttttt 3217861 ttaacctgtg atttcatcat ggtgatcaaa gaaatgctgc tttcctattt tgtgaaaaag 3217921 gcctgtttta tgcagtagct ccttcggctg cgattgcaat cctacaatca tcagctttcc 3217981 attgtggcgt ttaattcgat tcataatgtt cccaagcacc gcttcagctg acgtatccat 3218041 atagtgcacc ttattcatga gcagaataag ggttttcggt tttttctgta catgctccag 3218101 caatgacgat tcaagggaat caattgatcc gaaaaacagc ggcccttcta tggcatacat 3218161 gctgacagat ggatcttctc tcttcgccag aacaggatgc gtttcctgat tgtggatgcg 3218221 ggtcgcttcg ctcattcttc tgataaagaa cacgaatgca agcagcaatc cggttgccac 3218281 accgatgatt aagtcaaaca gaaccgtaag ggcgaaggtc gccgccaaaa taaaggaatc 3218341 agcatttttc agtctcagca tgtttgcgac ttccttgcgc tcactcatat tccatgcgac 3218401 caccatgaga atcggtgcca tactggcgag cggcacatgg gacgcataag gcgcaaatac 3218461 aagcaggaca aggagaacga ctacgccgtg aacgacgccg gaaactgggg aaaccgctcc 3218521 gttttttata ttggtcgccg ttctcgcaat cgctcctgta gccgggattc cgccaaacag 3218581 gggcgctgcc atattcgcaa tcccctggcc gacaagctcc ttgttgctgt catgctttga 3218641 gcccttcatg ttatcagcga ccattgcgga caaaatcgac tcaagtcctc caagaagcgc 3218701 gatgacaagc gcagccggaa acagcataac cattttatcc aaagtaagct caggaaactg 3218761 aaattccggc aaatggcggg ggatttctcc ataagttgac ccgatcgttg ccatgcggtc 3218821 agggaaaaag acaaccgcga ccactgtgga aataagaagc gccaacaaag cgcccggcac 3218881 tttaggcatc accttggcgg atacaagcaa aatgacgagc ccgatcacag ctgtcaaaat 3218941 ggcatacacg ttaaaggtgc cgagctgctg cacaatttca aacatgttgt gatgaaagtt 3219001 ctcatgtttt tcaacatttc tcaatccgag aaaattagcg atttgttccg taaagatcag 3219061 cacggcaatt ccggctgtaa aaccgacgat aacgggtttg ggcacgaatt tcattatttt 3219121 tccgagctta aacagcccaa acagtaccag catcactcct gccataaacc ccgcaatcag 3219181 cagattttcc aagccgtact gcatgataat gccgaataaa atcgggacaa aggcgcccgt 3219241 cggaccgcca atctgatatt ttgatcctcc aaacaaagaa atacaaatcc ctgctataac 3219301 aacagtgtat agcccatatt caggctcgac tcccgaggca atggcaaacg ccattcctaa 3219361 aggaattgcc acgacaccta ctacgatacc tgcaatcaag tctttctgaa atttctgcaa 3219421 attgtatccc ttgaatctcc ctgagaatcg catattttgt tataacctcc cttatgagtg 3219481 attgtttata agctcagttt cataaccgtt aatgaccaca tcaagttttc ctgtttcagg 3219541 gtgaatgaca agcccgtgaa ccggcacttt tttcggaagc agcggatggt tcttaatcat 3219601 gttcacactg tgggaaacgc tttcttccac gctgtgaaaa ccagtcagcc acgttttcaa 3219661 atcgagtccg gcactcgtca gcaaattcag gcagctatcc tccaccccgc gttcctttgc 3219721 tttctcaaga atcgaggacg cattcagccc tgacattccg cattcatgat ggccgacaat 3219781 gcatacctct tcagcctgca attcataaat cgcgaccagt atgcttcgca tcacgcttcc 3219841 aaatgggtga gaaacgatgg ctcccgcgtt ttttacaatt ttagcatcac cgtttttaag 3219901 ccccattgct tgcggaagaa gttctgtaag ccttgtatcc atacaggtga caatgacgag 3219961 ctttttcgaa ggaaactttg tcgttttgta cggttcatac ttcttctcac tgacaaaccg 3220021 ctgattgtgt tccaaaattg atgttaaaga aaccatttga ttcatctccc atccatatga 3220081 ttttgcaagc cttcttaccc agcttacagt aaggaattat agcataggaa taagccaaga 3220141 aaaggttttc aaaaaaagac actataattg gactgtagaa tcaaaacata aacatttata 3220201 tctttcaaag ataataaaat ttatatttaa tgcatcctat aatccggctg cagttcgtat 3220261 atcgatgatt tgtctgacaa aaaatatggg tgaattctga taattaaaaa acttttttaa 3220321 gcagatttag ctgttcgatc ttcattttaa gttcaaaaga accagaaatt aaaaaaacgc 3220381 agctatattt ttaacatcta tttattttcg atataatgaa ttagacaaca gccataaagg 3220441 gggagccttg ttgaaaccat ttgtatttat cacaaaaccg attcctgaag agattgaagc 3220501 attcatcggt gaacattgcc gttatgaagt atggcaggag gatacgcttc cgagtgacgt 3220561 gctatttgaa aaattaaaag aagcggaggg gcttttaaca tcagggacgt ccggaccgtc 3220621 aatcaatcgt gagttgctgg aacacgcgcc taagctcaaa gtggtcagca accaatcagt 3220681 aggctacgat aacttcgata tagaagcaat gaaagaaaga ggagtcgtcg ggactcatac 3220741 accttataca ctggatgaca cagttgcaga tctggctttt tcactgattc tgtcttccgc 3220801 cagacgtgtt gccgaactgg accgttttgt cagagcagga aaatggggaa ccgtggaaga 3220861 ggaagcgctt ttcggaattg atgttcatca tcaaacgtta ggcattatcg gcatgggcag 3220921 aattggagaa caagcagcga gacgcgccaa atttggtttt gatatggaag tgctttatca 3220981 taaccgacat cgcaaacaag aaacagaaga cagcatcggc gttaagtatg cagagcttga 3221041 tacattgctg gagcaatctg attttattct tctcattacg ccgctgactg atgaaaccta 3221101 tcacatgata ggagaacgcg aatttaagtt gatgaagaat tcagcaattt tcgtcaatat 3221161 ttcccgggga aagacagttg atgaaaaagc actgattcgc gctcttcagg aaggctggat 3221221 caggggagcc ggcttagatg tatacgaaaa agagcctgtc acccaagata atccgctcct 3221281 gcagctggat aatgtcacgc tgcttcctca tatcggttca gcaacagcta aagtgcgctt 3221341 caacatgtgc aaacaggccg ccgaaaatat gctcgcagcg atccaagggc aaacaccgaa 3221401 aaatcttaca agagaatttc aataaatcaa aaatccggtc tgataacaga ccggatttca 3221461 tattacatac gctgaagaac agcacgctta taaatatgac gggtgacgat ataataaaga 3221521 gcctggaata caaaataaat gaagatgaca attacggcct caagaaataa attggaattc 3221581 agcatattac ttaacgctgc atacgcaaag cccgcgtgaa tcgtacctgc gataaatggg 3221641 atgaagaata aaaatcctat ttgctttcca aggatcgagt gaatctcttt gtccgtaacc 3221701 cctatcctct ttaacgctaa cacctgcact cccgtatctt ctatttccgt aaacatccgc 3221761 aaatacagca tgcttccttg cacgataaaa aacagcacgc tgacaaacag accaataaac 3221821 agcattaatg caactccctg cttcacaatt tgataactag gagcacgtgt ttgaaaatca 3221881 gatgtatgtt ctttcggcac catgttttca agcttttcag agacatccac cgtctcctgc 3221941 caatgctcaa gctcataacc taccattctc atctgttcct tcagcggcac atcctgtgac 3222001 agactgtcaa agctcttttc gctgacaacc aataaacggc tgactccatc gacagacatc 3222061 aatatccctt tgttttgctg ctttttcatg acataggaaa gggtttttcc tgacttcata 3222121 tgaaatgctg ctgtttcccc ttctccaaat gtgtctttca ccatcatttg aaaagaaaca 3222181 ttaataaatg cttcattttc ttgtaaatga ataactggga accctttttc ctttgcgact 3222241 tgattataga ctttttctga aatcagcaaa gcttcagctt ccatcttctt atttccatac 3222301 ggcaagtctg actgaaaagt gacaggaatc cctgtggcat ccaccttata cgtgataaca 3222361 gcatgagctt ttttcaatgt attctcagcc gtctcaggct tcatgacctg aaagcgggaa 3222421 gcatcctttt ccacccagga aacagactga ggaatgcttt gctcctcctg cctttgtaaa 3222481 tcggaataaa acatatagat gacacctgta gctgttagta tgaccgctgt aatgacagag 3222541 gttaaaaaca gcatgcgtgc atgatccttc agcctgaata tcatgttgga acgcacaatg 3222601 atatttgtgc ctttgtagaa gctgtgtttc tttcggtaca gcatgcggaa aaatgccaca 3222661 ctgctttggg taaaaaagaa atacgtgcca attaacacta aaatcaaaat tggaaaaacc 3222721 cgaaacatca tgtcaattgc attggctgtt gcagatagat aataaccgct gccaagacat 3222781 agcaaagaca atacagtgag ccatttcgaa taaactggca aacttttcgg ctttttggct 3222841 gatttaatca gttcaatgat ttccagcttc cgaatccgtc ccagtgataa aatgagcagc 3222901 gtctgaaaca ggatgagaaa gccggcaatt gtcatcacaa acgctttcgg cacaatggca 3222961 aacgaaatcg gcaccttcac gctgagcatc catgtcatga tcataaaaaa cagttttgaa 3223021 aataacaggc ctgctccaat gccggccgca atcgccgcaa gagaaataag tgactgctca 3223081 taataaatca tcttgcgaag ctgctgcttt gatgtgccaa acagtgtcag cagcccaaac 3223141 tctttctttc ttgcctgcaa aaacgctgaa ttggaatatg tgatgaaaaa tatacaaaac 3223201 acaatgatga cgacaagagc tgcgctcaag catgttttga caaggcttcc tccatatata 3223261 ttgtcttcat tgacatcagg atgaaaaata aatgatgtga agacaaaaaa caccgaaacg 3223321 gcaaacacac agcttaaaaa gtaggccaca taccgttgca gattcccaag aatgttttta 3223381 cgggcgatag ttctcaaatt catgaaaatc gcctcccaac acactcaagg tatccaatat 3223441 actttgataa aacacctgcc tgtttgttcc tctgtgaatc tctgaaaaga aacgtccgtc 3223501 tttaataaaa acaatccgtt tacagaaact tgctgctgtg gcatcatgcg taaccaacaa 3223561 aatcgtcgct tccttttcct cattcagctg agccagtgtg ttcatcactt gctttgccga 3223621 ttttgagtcg aggtttcctg tcggttcatc ggcaagaatg agcgccggat tgtgaataat 3223681 cgctctggca caagctgccc gctgctgctg tccgcccgac acctcatatg tgcggtgatc 3223741 gagaatatgc tttatttgca gcgtatccgc cagttcatcc aatcgagctt ccatttctct 3223801 cagctttacc ttatccaatg cgagcggcaa gagaatattt tcacgaatcg tcagcgtatc 3223861 aagcagatta aaatcctgaa agacgaagcc gagttctctt ctgcgaaaca aagccagctc 3223921 ttggtccttt aacgttttcg gctgaatgcc gttgatcatc atctcgccct gggtcggctt 3223981 atcaatggta gccagcaaat tcaaaagcgt ggtttttccg cttcccgacg gccccataat 3224041 cccgacaaat tctccttttg acacactgag atcaaaggcg ctgagcgctt ggtatgatat 3224101 tgttccttta tttgaatagt atgttttcga taggttcgtt gtttgcaaca cgttcatgtt 3224161 ctgctcctcc tttttcttta ttataaaaag gaagtcagca tcctcccatc gaactttctt 3224221 gcaattccgc tccccaatct tacaatgctg tcacattcac gagggtgtca cttgaaaaca 3224281 cgatggtcat cacagtgcca gccccttctt ttgattccgc atacagctta tggccgagac 3224341 ggctgcacac ctgttttgct aaataaaggc ccattccagt tgcctctttc atggttcgtc 3224401 cgttttctcc ggtaaaaaac gcgtcaaaaa tccgcggcag atcctgcggc ggtatgccga 3224461 ttccttcgtc ggcaaccgac aagcgcgtct catgtccctg tgtttcaatc cggattgtaa 3224521 tagggtctcc cacaccttgc tttgaatatt ttaaggcgtt gaaaaggatt tgctcaacaa 3224581 caaaggaaag ccacttttga tcactggaaa tctgaacggc atttggcggc acatgtaatg 3224641 ttggaaaaag gcgccgcttg ataaactgac gtttttcctg attgatcagt gaacgaacca 3224701 tttctgccaa atcaaaggtt tgcggcttta catcaaatgc aaattcctcc agccgggccg 3224761 tttgcagcat catatcaaga ccgtggcgaa atctctcatt ctcatcctcc agctcctcta 3224821 aaaacgtcgg aaaagaggat gaggttccgt tttttccttc ctgaatcatt aaggatatga 3224881 cagataccgg tgttttcata tggtggaccc attggttggt gaaggtgtaa tgctgttttt 3224941 gctgattgat atattgtgag agcctgcttt cgtattgctg cccgagtgcg ttgatcatct 3225001 tcgtccaaag cgcttgctct cctgttcttg gctttctggc tttcaaagac tgtccgatgt 3225061 cattcgaaga agaggcttgt tctgcaagct ttttaacata tgtgagaaag gaaaattgcc 3225121 gaacataatc agcagcaaaa cctgcggcta aaagagtacc gggcaaaatc catatgtaca 3225181 tcatattttc tttggaaggt tctgcgccgc tctctacaat gcttaaatac gcaatcagca 3225241 tggcggaccc tatccctaat aatgaaaata gaataatggc taagcggtcg atgagataag 3225301 tctttaacat tccgcttcat ccttccgatt gacttgaaat tgataacctt gtcctctgat 3225361 tgtggaaatg caatctgtca gtcctgcatt ctccagtttt ctccgcagcc gattgacatt 3225421 gaccgttaac gtattgtcat cgacaaaatc aacgtcatcc cataacgcct ccaatagttc 3225481 atcacgagag acaatttttt tatgctccct cacaaaaatc gagagaagct ggaattcttt 3225541 ttgggaaaac aaaatccgga cgctgttcca ttcggcctca ttctgatcag gataaatcgt 3225601 cagcccgcca agctccacta ttctagattc ctgcggcaaa gagggcgaat attcaccata 3225661 tgtgcggcgc aggacgcttt tgattttggc catcactacc tctagatgga acggctttgt 3225721 gatataatca tcgccgccat tttcaatcgc cattacctga ttcagctcat cggtccgtgc 3225781 cgatataaag ataatcggcg cattggaaat ggtacggatt tgcctgcacc aataaaaccc 3225841 gtcaaaaaaa ggcaggttga tatcaagcag cacaagatca ggcttcattt ctgcaaattc 3225901 caattttata tcattcagct gttcagcaat tttcacttca tatccgtatt tttgaagatg 3225961 accgcccagc aaagaagcaa tccgctcatc atcttccaca agcaaaatcc gatacacgtt 3226021 gatccccctt atatgtacat cacgatgatt tttctagaag attccaaaat tattatagca 3226081 tgtgcggaat agtaaatcgg tctttttctt tttgttatga tagaatgata aaggtaaaat 3226141 tttcataata ggcaggtgtc gtgatgaaga aaatcatgct gtttctggca atgacgtcaa 3226201 ttctttcagc atgtcagccc aactataccg ggaaatacat agaaattggg gatacactaa 3226261 ctgactatac caaagagtgc tttaaagaga atgaaattcc ttataaatac gaaaagggaa 3226321 aactgtatat cccagaagac gcatttgata cagcaatcta cacttgttca taagaaaaag 3226381 cttgcagata acctgcaagc ttttcacgtt acaaaaaatg agtatttaat ttctcttcaa 3226441 atcctgaagg gccgatgtcg cttttttgaa tgttaccgcc gttttcataa atcgtaaaat 3226501 ggcgctctga catgaccatc cttccgctcg gcgtcagctt tgaggcaagc agggatttgt 3226561 taaaaggaga tttttcatga gagtgaatga tgtccttcat gttatctaaa tcaccgagat 3226621 cactctcttc aagggtaaag gcgtacccaa tttgccagcc ttctcctttg tccatcagca 3226681 gaacatagct gcccttttct gtctcttcct ttttgattcg gaatgacccg actggtgact 3226741 gtaccgtttc tccggaaagc ggtatcggct ggagcgccag gttgatgccg aagccgatat 3226801 caacgaggta atcgccgttt tccgcagaca gccatacagc agcatgcgtc ccttctagtg 3226861 cccatccctc ttgatcgcct gcataaaccg ttcctcgaat gagcttcaca tgaaacccgg 3226921 cctcacgcaa gacaaaataa aggaaaccat ttagatcgta gcataggccg ccgtgctgat 3226981 ctttgagcag acgtcgccat agctcttctt ttgtgatctt ataattctct tttgcaagta 3227041 cggcacggtt ttcgaatgga aaacggtatg ccattgcttt aagaaaaagg ggaagatcgc 3227101 cgaagctgac atggtctttc tcccagccga ttttctgaaa gcagtctttt agaaagtcac 3227161 tcatttttat cacctaaact tcttcttgaa cgtaagcagc cagcttctcc agcgcctctt 3227221 gttcatcttc tccctgggca atcaaggtaa cctcagtgcc tgtgcttacc gcaaggctca 3227281 tcagccccat gatgcttttg gcgtttactt ttttcccatc cttctcaaga aacacatctg 3227341 acgtaaaccg gtttgcttct tgtacaaaca aagcagcagg acgtgcttgc agtcctgtct 3227401 ttaatcgaac ttccactttc tgttgaacca taagatctcc ccttttcttt acggttattt 3227461 taaagtgacg gtttgccctg tccgcagctg ttctgcgatt tcgtcaagtt ttctcagcct 3227521 gtgattgatc cctgatttgc tgattttccc gcttgctacc atttccccta gctctttcag 3227581 cgtcacttcc tgataatcaa tccgcagctg cgcaatttcc cgaagttttt caggcagcgc 3227641 ctccaggccg attctttcat cgatgtattt aatattttcc acctgtctca gcgatgcgcc 3227701 gatcgttttg tttaagttgg ctgtttcaca attgacgagg cggttgaccg aatttctcat 3227761 gtcccgaacg attctgacat cctcaaatcg cagaagcgaa ttgtgagcgc caattacgtt 3227821 cagaaactct gtaatctttt cagcctcttt taaataggta atatagcctt ttttccgttc 3227881 aagcgttttg ctgtttaact gaaactcatt taacaggtca cataatgaat cgttatgctc 3227941 cttataaaga gagaagattt ctaaatgata cgaggaggtt tccgggttat tgaccgaacc 3228001 tcctgccaaa aatgctcctc tcatataaga acgcttgcag catctctttt tgaccagctc 3228061 tttcgaaata cttcgttcaa acacaaaatt ctccccgagt atttttaaat cctctaagat 3228121 cgcttttgca ttttctgaaa aacgcacaat atagacgtta ttctttttca gccgcatttt 3228181 ctttctgacc agcagctcga ccgacacatc atattgtttt ttcagcaatg tatagatgcg 3228241 gcgggcaatc gccgcgtttt cggtttgaac atcgagtacg agatggcggt ttgtaaatga 3228301 taaagctcca ttcatccgaa tgagtgcaga cagctcggca ttaatgcagc agtccttcac 3228361 ttccagattc gttaattctt tttttgtttc tgatgcaaat gacatatagc cacctcattt 3228421 caaggcttca ttctttcagt aaatcaacaa gaagagaggc cactttatgt gtatcgtgac 3228481 gtattacgtc atttttatac gttacaattt gatctctgat gacttcaagc cccatcgctt 3228541 tcagctcttc gatatcaaaa tcaacaggac gcgccgattc catttcgtac ttacgtttta 3228601 tttcgtcggg aatgtcttca ctgttcacta atatcgtatc aataaaacca cagcccatat 3228661 gctgattgag cgctttcaca tgatcagcag cggtgtaatg gagcgtttcg ccgggctgag 3228721 tcatcacgtt gcaaatgtat acttttttcg ccggcgcctt tatcacttct tccccgattt 3228781 ttgggacgag caaattggga agaatgctgg tatagaggct tcccgggccg ataataatca 3228841 aatccgcttc cctgattacg tctattgttt ccggcagcgg atcaatctgt tcaggcgtga 3228901 gaaaaacacg cttaatgcgc tgtccgtatt ctgggatcgt tgactcgcct gagaccacgc 3228961 ggccatcttc catctcagca tgcaaaacga cactggcatt ggcagccggc aaaacctttc 3229021 ctcttacatt cagcaccttg ctcatttctg tgacagcgtg aaaaaaatca ccggttatat 3229081 ttgtcatcgc tgccaaaatc aaattcccga gagaatggcc tgttaagtca ttccctttat 3229141 tgaagcggtg ctgaaaaaga tcttcaacaa gcggctccac atcggataaa gcggcaagca 3229201 catttctgat gtctccggga ggcggaattt tcagttcatt ccgcagacgg ccagagctcc 3229261 ccccatcatc ggcaactgtt acaatggccg tgatgtcaac gggtttatgc tttaggcccc 3229321 gaagcaatac agaaagacct gtaccgccgc caaagattgc gattttcggc ttttgtccca 3229381 tcttatttcc ggcttctctt ttcaatgtcc cggtgagtaa catgagtata gtaatccttt 3229441 ttgaaataat cagctaaatt ctcggctaat gtcacagagc ggtgctggcc ccctgtgcag 3229501 ccgatcgcaa tgacaacctg gctttttcct tctcttttgt aagatggaag cataaagctc 3229561 agcagatcaa ttaatttctc attgaacttt tgcgtttcat tccacttcat gacgtaagag 3229621 gaaacctctt tatccttgcc agtcagcggc cgcatgcttt cgatatagta cggattcggc 3229681 aaaaatctga catcaaagac gagatctgca tcaattggaa taccgtattt aaaaccaaat 3229741 gacatcacat ttacggtaaa tgtctctcct tggtttgtcg caaagtgctt cacgattttt 3229801 tcacgcaaat cacgcggctt catgtcagac gtatcgtaaa tgatttgaga gcggcctttt 3229861 aattcctcaa gcagctctcg ttctagcgcg atgccttcaa gcggcaggcc agtcgctgcc 3229921 agcggatgcg agcgtctcgt ttctttatat cttgtgacga gaatggaatc cttcgcgtcc 3229981 aggaataaaa ttcgcggtgt gatccacgga ttttcggcca tttcatccag cgcttcaatc 3230041 agccggtcaa aaaattcgcg gccgcgcaaa tccatcacga gcgcaacttt gctcattttc 3230101 gaatttgatt ccttcatcag ctctaaaaac ttcggaagca atgaaggcgg aagattatcg 3230161 acgcagaaat agccgagatc ttcaaagctt tggatcgcga cagttttccc cgctcccgac 3230221 attccagtta taatgacaag ctgaatatca tgtgattcac taacactcat ctttctcccc 3230281 cctgacttgt ctttctattt gatgtgctgc gggtctaaac gataactgag cagctcaaat 3230341 tccggtgtat acgtaaatgt gccgtgcagc agcccttgtc ccttcatcat aaaatcaagg 3230401 atatggccgt ctccaggggc cataggcagg ttctgaatgt cattgacatc gtgccactgc 3230461 agtttgcctt cctctgattc tgatacattt tgtcctgtat atgaatcagc gacaaacgta 3230521 aacatcatcc actcggagac aatgtggtca ccgtctttaa taataaaggt aaaaacgcct 3230581 tttaattgag gatttatgat atagatacca gtctcttctc tgtactctct gatgacggag 3230641 tctctgactg attctccgct ctccatcttg cctcccggcg cgacccacca tccgcgtctc 3230701 ggcttttgaa gcagaagaac tttgtcatcc gtctgaagca cacaatttgt cactctttgc 3230761 aagtacgtca cctaaccttc gtcctgtcat cgtctcttta ttataccgct tcaagatgcc 3230821 tcccacaatg aagagacatt gacaatcttt tcttctattt tacagcatat tcattcctta 3230881 attcagatga ttttgctgta actggaattc tcttttattt atggacaaaa aaaggacacg 3230941 gataactgga gaatccgtgc caaaaaagtg tattcattat aaaaaggggg tcaattactt 3231001 tattaatcat aaccgaaaag cattacacat gtgttacagc ggaattaaaa cccagtaacg 3231061 taatgtgaaa ctcgtatgac agcccttttt attttaaggt tttcagcgtt tcttggagct 3231121 cttcgacata atgttgtacg ctttgtgccg caatgcttcc gtctcctgta gccgttacga 3231181 tttggcgcag tgatttttcg cggatgtctc cggcagcgaa aatcccttca accttagttt 3231241 ccatgcggtc gtttgtttcg atatagcctt cttcattcgt aatgcccagg ttttcaaacg 3231301 gtttagacag aggaagcatg ccgatgtaaa tgaatacgcc gtctgttttg aattcacttt 3231361 cttcaccggt taccgtatcg acaagcgtta cgttaccgac tttgccgttt tcctcatgaa 3231421 tttccttcac agttttgttc cataggaagt caactttttc attatcaaat gctctcgctt 3231481 gaagaatact ttgagcacgg agtttatcac gtctgtgaac aatcgttact tttgaagcga 3231541 aacgagtcag atatacgcct tcttcaaccg cggaatctcc gccgccaaca acgacaagtt 3231601 ctttgccttt aaagaaagcg ccgtcacata ctgcacaata agatacaccg cgtccgccca 3231661 attctttttc gccaggcacg ccgatttttt tatattccgc acctgcagca atgatgacag 3231721 cacgggcttt atattccttt gaaccagctt tgactacttt gtactctttg ccgtcaatga 3231781 cctctttaat atcgccataa gcgtattcag cgccgaattt tttcgcgtgt tcaaacattt 3231841 tgttagaaag ctcaggccca aggatacttt cgaatccagg atagttttct acatcttccg 3231901 tattggccat ttgtccgcca ggaattcctc tttcaatcat taatgtcgat aaattcgctc 3231961 ttgatgtgta tacagcggcc gtcatcccag cagggcccgc gccgattata atcacgtcat 3232021 aaattttttc ttctgacaca ctattcactc cttaaaccat cttttcaagt ttgggctctt 3232081 tcttataaga taagaatccc catcaaacgt attccttacc catatcctat aaaatctcat 3232141 ggtgatacgc tatttttttg ctcaacacga ttaaatgtat tcgaaaaggg tatatgttaa 3232201 taaagaaaga gccttctgtt tatagaaggc ccttgtcata tttattattg aacaacacgt 3232261 cttacaacac ctttaaatgc tgctttccag taaggattgc tcatagagtc aacagatacg 3232321 ccatgagatg tattgtcgtt taggaaagta ccgtttccta agtagattcc tacgtgtcca 3232381 tttgttttgt aagtgtcaaa gaacacaagg tctccgcgtt tcatttcaga cgcgctgaca 3232441 gcttgtcctc tgccaactaa cgtatcagtt gttgttccgc ctacaggtcc aaggttaaca 3232501 cctgcagaag cgtatgccca gcgtacgaat gatgagcagt caaaaatacg gttgttgata 3232561 tcagactgag tgcgtccgcc gccaaacttg tacggagatt gtcctacaat gcttgaacca 3232621 acgctgatcg cgccttcaat tccgccagag ttgctgataa cagtgccgcc tgaattgctg 3232681 tttgagccgc tgctcttctt agaagatgag ccgtttgacg aactgtttga tgaaccgtta 3232741 gaagaattgt ctgaagaatt gtctgaagaa tcatcagatg agcttgcttt tgatgattca 3232801 gttgtcgccg tttgactgtc atctgtttgt gtttcatcag atgctttttg tgcttcttcc 3232861 tgctttttga tcaaagcagc cgctgcttct tgttcttttt tgatgcgtgc ttgttcagct 3232921 tcagtatttg ctttttgatt tgcaagttca gacgcctctg attttaattc agaaatcgct 3232981 ttagccgttt tcttttggct tgcttttgct tcgtcgaaaa gcttgtcttt ttcattaagc 3233041 tgtttatcaa ggtctttttg cattgtttct aatttagcca aggcagcttg aacttctttc 3233101 agcttgtcat tcaaatccgc ttcagaatct tcgagcttcg ctttatcctg ctcttgctgt 3233161 ttgattaaat ctttgtctgc gtccacaata gatgaaaccg cagtcgcacg agagataaag 3233221 tcaccaaagc ttgttgatcc taaaagaaca tctatgtatc cttgagatcc gccgctttcc 3233281 tgtaaagaac gaacgcgttt tttcaggatt tcattgcgtt tttcgatgcg tgcttcagtt 3233341 tctttaatct cttttttcag ttttttgatt tcttcttttg ttttatcgtt ttcttctttt 3233401 ttatcttcaa tcttgttgct tgtatcaagc gccttatcgt taatgtcttt cagttctttt 3233461 tcaatctttg attgattttc ctgaagctcg gttaattctt tttccttcgc ttcaatgctg 3233521 gaagcaacct cagattgctt gctttcgatt ttttgtttct tttcatctaa tgtttccgcc 3233581 gatgcagttt tacttgtaaa tgggatcaaa aaactgcttg tcccgatgac ggaagccaaa 3233641 ccaagtgtaa ttaaactctt tctcactttt tatatcctcc cttttactgt gaacctgtcc 3233701 tcatttggaa tcgtattttg aacatcaagt ttcgttcctc atactctacg aggaatgatg 3233761 gttgtttatg gttaattatt ctgtgcatct cttattctgg ttgtatagcg tttatttcac 3233821 atcatatgta aaaaacacta attccttatg tacgagaatc attataccat caagtttcga 3233881 caaattagcg ataaatttta ttacatttat gtttcaaaca gatgtcaagt cacacatcat 3233941 ttgtcatttt tcttaagcgt gtaaaaaaac tgtcgatatt attttcttaa tataatctat 3234001 ctaacaaaaa aagagtcgat taaataaatc aactctttaa aatttactat tctagaatat 3234061 catcaatata tttcatatat ttcgtcaaag ttgccggaga gatgccgaat cgggccgctg 3234121 tgtctttttt cgtgtcttgc ttgccatggg cttctttcca aatataacag atggctgctg 3234181 cccagccttt ctcattcttc aacggagcag ctgcacgaat ttgctggatg acatgaaaaa 3234241 cccagcagct catgacttct gttttcatct cttctttttc agcttgctct aatagtttga 3234301 ccgtttgata agcgaaaagt gcatcctctg aaacgtcagc agccgcagaa tctccattca 3234361 gaagcagctt tacaaaatga gtttcaaaag gagcggtaat tctctttgag cgtatcaccg 3234421 cttcaagatg ctctgtttct ccctttgtgc tgctgatata ataggctgcg agtcgctgct 3234481 ccacagatga aggaagagct tccctccgct caatccaagg cgccgggcgg tcttcgccgg 3234541 gatattgcga ctcgactttt ctccagatcg tctcggcaaa gtcggtatgt cccgtaaaat 3234601 aagcagagca ggaaagccag taaaagaagg tgtcgtcacc ctcaaagccg gttttatata 3234661 atgatttgag ccatttatat ccgatctcgt agcggccgac aagcgccaaa gtagcaccca 3234721 atttataacg ctgctccaat agcatcggat agacattgga gagctgatca ctcaattccg 3234781 ccactttttc gtcttctctt tcataatagt agaaaacgag aagattgcat aaggcgtgaa 3234841 gatttccttc attatgagaa agcacttcat aagcggtttg cttcgctttt acaacgtttc 3234901 ctgaatagaa ataggcaagc gcgagattgt tgtatgctga ccaaagctcc ggatattcag 3234961 ttgtgatttc ctcaagcgcc gcaaccgctt cagcaagctg gccgctttcc agcaatgact 3235021 ttgcccgatc ctgtttcacc agcagttcat cctgatcata caacgaatcc tcaatgccgt 3235081 cgtctcctaa atcgagcaaa tcaagcagac tatcgttttc ttcggcgaat tcaccatccg 3235141 ggtccgcatc agaataagcg gccgcttctt tataagcttc ctggaagagc cccagatggg 3235201 caaagttatt cgctttaaag taatggcact ccggcatttc ggcctccaga tttgccatga 3235261 tatagtcaag aagatcgttc gactcttgat actggcccat ttccgaataa atgaccgcaa 3235321 gctgtgaaag catctctgaa tcctccggct ccaaatgaac cgcgcgctga atcagtttgc 3235381 ttgcccgttt tagattgcgc tctttatacg ctttcaagcc tttatgaaaa aaatattgtc 3235441 catcttgaag cagctggaca atttgtgcgt gatttttatg ttcagaagtg tgttttccca 3235501 caactaccct ccgttttata caatattacc gtcagtagta taccataaat cgtaagcccc 3235561 tcaatagttc aaaaggaagg attgggaaaa tccctcctct tttttattgg ctgattcgac 3235621 caaaatttac ccggctttgt tttctaagtc cgcattcatt ttcagctgct gttcagcaaa 3235681 atcccggtaa aggccatggg aagccattaa ctcatggtgt gttccacgac cggtaatttc 3235741 ccctttttca acaaacaaaa gctggtccgc atctacaacg gtagataggc ggtgagcgat 3235801 aacaatcgtt gtgcggccct ccatcagcac ctccagcgcc tgctgaactg atttttcaga 3235861 ttggctgtcg agacttgagg tagcttcatc gagcataaga atgcttgggt tacggagaag 3235921 cgctctcgca atcgcgattc tttgcctttg tccgcctgac agcataatgc cgcgttcgcc 3235981 cacttctgta tcaaactgat tcggcagctc ctttataaaa ttgagcgcat atgccatctc 3236041 cgcggctttt tcgatctcag catccgtcac atctcgttct aacccgtagc aaatattttc 3236101 tctgattgtc ccggacatta acgggctttc ctgtgataca tacccgatat gctccctcca 3236161 cgattcaagc gagtaagtat cgaccggctc gtcccccagc cgaatggtcc ctgcagtcgg 3236221 agaataaaag cgttcaagca gcttaaacag cgtcgttttt cccccgccgc tcggaccgac 3236281 gatcgctgtc actttccctg cttcaatgac ggcgctgacc tcttttaaga tcagctgatc 3236341 aggcttatat ccaaaagaca cgcgatcaag ctggataggc agatgtgcat tttcaatttg 3236401 ttttcctgtc actgtatctt cctcttcctc tgccaaaatc tcaatcattc gttctgttgc 3236461 accgattgat ttttgcagct gtgtgaaaaa cgttgtaatc tggcccatcg gcataataat 3236521 ttgaaacaaa tataaaataa aagccacgag cgctccggct gtgagctcgc ctgatgagac 3236581 ctgcatgccg ccatatccga tcactgcgac aagcgctgcc attaacacga gtgaaataag 3236641 cgggccgaca agcgattgaa ccttggcttc acgaacgcca agcttaaata atgaggaaat 3236701 ccccatcttc ccgcgcccat attcgacatc ctccgcattt gaagccttaa caagtctgat 3236761 ttccgggaga atttgattaa gcaggcctgt aaaacgagcc gtttcatctt gcgtttcccg 3236821 tgaaatggag aacattttcc gtccaatcgg caccaaaata agagcggcca gcggaacgac 3236881 cactaacaca agcagtgtca gcttccagtt cataataaac aagattgtca atgatccaat 3236941 gacagaaatg atgcctgtaa taaatccgct gatatgggtt gtaatcaatt ctttgaccac 3237001 catcgtatcg ttcgttacac ggctgactgt ttctccggaa gcatttgtat cgaaataaga 3237061 gacaggcagc ttaattaatt tcttccataa taactcccgc agcccggaaa tgattttttg 3237121 tccattatag ttaagcgcat aggtggcata agcgcttaaa cccgcctgaa cgaaaaacac 3237181 cagcgcgatc aaaccgattt gcgtgcctga cagatttgac atagaaaaac catcgacaag 3237241 ctgcttcgtt aataatggaa tgagcaggct gaccagcgtg gttactacac tgagggcaag 3237301 cgcaaaggcg agctttccat aagaaggatt ggtccgtctt actaaggcaa aaaagggttt 3237361 caatttactt ttagattttt gtttcttggt tggcatatat tttcctcctg tttcagcgtt 3237421 cagaaaggtg aaaagtcata gcaaaaggat gatttttact ctttctcaat catatcaatg 3237481 gagaaagact ttttcagtat atttttgccg tgatcaaaat aaaaatctcc cactcattgt 3237541 ttgaatagga gatttttgtg ttagacatct ttcactggct tcttttttct gtaagtcaat 3237601 gttacatcct gctgtcgcag gtcttctatt atcattttgt accgatcaac ttttgcggta 3237661 tgttcttctt ttatcatctg aagggcagct tttcgttttt cgctattaga ctcaagctct 3237721 ttttttattt tttttacaat caaccctttt tgccctttga tttcctcttt taatgaagac 3237781 tcaaatttct ttgtcaggct gagaaagtcg ttgatcggtt gattgagggt gcccgctttc 3237841 cccttcattt catcttgggt aagaaacata taggtcgttg atacaatttc tgtttcactt 3237901 tctgaaaata aggaagtcac tcttcatatt cctcctaaga ctgaaaatca aataactgag 3237961 aaatcatttc ttctttttca aacagctttt caatactctc gcggatattt ttgataaaat 3238021 ctcttttttc tgttgtctgt ttttttaatt cagcaacaat tccatcattt gcaggaagcg 3238081 cacctgtgtg gaatgattca tgaactgaga ttttctccaa tttatcgaat gtgtggctga 3238141 aaccagctgc aagccggaat tgaagatcga aggcataatg cgaagggttt tcttccatat 3238201 gatgaatagc cgtgatgatc gcctgctttt tgtctatgaa gtcttcatcg atttcctgac 3238261 tgtaaacctt ctggtactta gaaatcgcat cttccatatc ttcaacgatt ttcataccgt 3238321 tttgatagat tctgacagcg gatgagagat tgacttgaat cgtttctccc gagccactct 3238381 tccctgtaaa ataaatatcg gagcctttat agctgaagcc tttttccttt gacaaggcgt 3238441 tgagcatttg aacgatgctg tggccgtcga cgataagttt tagtgcgtct tttgtttctg 3238501 tgtcgagtgt tttcaatgag gacagaattg attttacata gtccactatt tcaccaacgt 3238561 cttttaaagc ttgcataaat tggccatgtt ttagatggtc tatgaaatgt tcgtaccgtg 3238621 actctatgcc tcgcatactc gcattaatat tcgttaattc ttttttgatg actttctttt 3238681 gcgtttcatc aatataacca ttttcagcta actgatctac gaccggtccg ctgtttctca 3238741 acaaggtatg aagaaaacct aaaaacgacg gcagttcctc ttttattcgg ccatacattt 3238801 gcttaacatc atcaaaatgc tcatatagga cacttacttt ctttaaagcg ccgtctgtgt 3238861 ttttcacttt ttcaatcagg tctatgtcta tcccgctggc tgcctttata aaaccgttca 3238921 agccgtcttt ttcatagtca tccttatatt tttgaaggaa tttttgaatt gacctcacat 3238981 cttcgtcagg aaccccatcc ataatgtttc ggatgccttt tacacttgta tttgtatctg 3239041 ccatcttcac atcaccgaat gtaataaaat cggccttgcc gctgactcca tacagcgggt 3239101 catcttttga gatgcgctga gtgatgtttg ttgttacgcc tttgtcttca taatattttt 3239161 ggatttcttt ttttaacttt tctggcggga tggaatctat atcttcatat ttataactaa 3239221 atttcctaat aacatatcta tataaacttt catcagtttc aagtaattga tcaatattga 3239281 cttgagctcc atttacccca taaacttcat catattctcc atcaatcaat tgcaccataa 3239341 cttggttatt atttgcaagt gaatgtccta aggcgaatgt ttttaaatcc tcagagttac 3239401 ctgctgcttt ctttgctttg ttagtaaact cctttgtagc ctcatactga ctatgatcaa 3239461 ttcctaaaaa aagaccaaaa aagttatatg accaatcctt attatcggca ctaccttctg 3239521 aaataatctg aagctgatca atatgttttt tctcatctat tatatggatt gccgttccat 3239581 cgtaacctga ttctctggtc gaactttgta tacttgtatt ctgatttaca agttcattgg 3239641 aggtgtaaat ttcaattttc atattctcag gaagatcgtg gtgggtttcc tctttataaa 3239701 ttctgcgtat atctgcttcg aaatccttct tagctttctt aacttcactc gcaatagttg 3239761 aggcaaactt ttgtttatag tcatattcta aatcaattaa ccttaacttt acgttctcat 3239821 tctcaaatac atttttattt cccatcttat ttctcctttt tatctattaa aaaggtgata 3239881 gaattaatta atttctcaac tttattttta gccttttctt catctaagga gcatggttga 3239941 ttttcatttt tgcatccaag ggtaaaggcg tattctactc ctaggttatc ttcctctgta 3240001 gacttaacat atccaaaata actgtatgaa taattatatt ttctatcaat atcgtcaaag 3240061 atgtcttttt tcttggcagt gtaaatatcc gttttctttt tgctgctttt tttgtattcg 3240121 cctttataat cattttttcc actaacaata tctagcattg tcttaggttc attcgcaaaa 3240181 ctttcttctt tgtaatatgt tacatggcca tcaaacatta cattggtgtc tttatcataa 3240241 ctattaaatc caatactttc tttgtttttc ccggttaacg atgatcttct tgatagatac 3240301 tttccatcct ccggaaacaa catcctaaac cctttcagct tagattccag caaataatat 3240361 cctggttcct cttcttttgt tgacaccatg tactctctcg ttttctcgtc ctgaaacgca 3240421 ggtacttgag gcagatcctt gggatccatg tcttttggtt ttaccgcttc tgttttattg 3240481 tcatttgtgc tgtttttatc attgtcattc atactgcatc ctcctgtcag ggcaagtaat 3240541 aagctgaagc aaataaagat gatctttttc attacgaacc tccacgggtt ttgtgagaat 3240601 agtattctat ttttatatca aaaataattc tattgacctg gttaagagat gattatttca 3240661 tcctttttca tgttacatca tggcggaatt tggataaata ggaaatgaga ctcggttttg 3240721 atctcctttt attaactaat catatataac acccaatata aatctaaata cctattactt 3240781 ttttcacaaa acaaaaagag ccgtatcatc cggctcttta ctcttcaatc tcagaatggc 3240841 gttttttcaa tacgtcaagc acatcatcca gcggcaggga ttgttctctg agcaggacaa 3240901 gcaggtgata cagcaggtct gccgcttccc atttgagttc ctcatgatcc cggtttttcg 3240961 cggcgatgat gacttcggat gcttcttctc cgactttttt caaaatctta tcgacgcctt 3241021 cacggaagag gtacgtggtg taagctcctt caggcatttc cgcttggcgt tccgcgatca 3241081 cccgctccag ttcgttcatg atgccgaatc ggtccgcggc ctgttcttct gtttgttcct 3241141 ttgtaaaaca gctgtagctg ccagtgtggc atgccgggcc tgacggttct acgagtacga 3241201 gcagcgcgtc ttgatcgcag tcataccgga tacctttgac ggcttgcgtg ttccctgagg 3241261 tttctccttt atgccataac gcttggcgtg agcggctgta aaaccatgtt tccttcgttt 3241321 ccagcgtttt ttcgtacgat tccttgttca tatacgcaag tgtcagcact tctttgcttg 3241381 ccgcatcctg cacgatagca ggaattaatc cgtcctcgtt aaaacgcagt tcatctgcct 3241441 gtttcatctc acattcaccc cgtactcttt caagtatgat ttcacttctt taatcgatgt 3241501 ttctttataa tgaaaaattg aggcggccag cgcggcgtcg gcttctcctt ttgtaaaagc 3241561 ctcaagcata tgctgtgcgt ttcccgcgcc tcccgaagcg ataacaggga cggggacagc 3241621 ttcggaaaca agctttgtca gcgtgtggtc gaaacctttt ttctcaccgt cggagtccat 3241681 gcttgtcagc aatatttctc ctgccccgcg tttgacgcct tcttttgccc acgcggtgac 3241741 ctcccaatct gttttctttc tgccgccgtg cgtgtagacc ttatatgtgt cagattcttt 3241801 gtcatacttg gcatcaatgg caagtacgat gcattgagaa ccgaaaaact cggctccttc 3241861 tgtaatcagc tcagggcgga gaacagctgc cgtgttcacc gacactttgt ccgctccggc 3241921 acgcagtatc gttttcatat cgctgagctg attgatgccg ccgccgactg taaacggaat 3241981 ggcaagcttc gcggcaacct gctccacaac gtcaaccatc gtctttcgtc cttcgtgcga 3242041 ggcggagata tcaagaaaaa caagttcatc cgcaccttcc cggtcgtaca cttcggcgag 3242101 ttcaactggg tcaccggcat ccttcaattc gagaaattga attcctttga caacgcgtcc 3242161 ttctttgaca tcaaggcatg ggataatccg ttttgtgatc atttgcgctt caccctttca 3242221 agcgcctcac tcagcgtaaa ctgattggta tacagcgctt ttccgatgat cgctccagag 3242281 acgccgtccg cctcattgcg ggcgagagct tcgagatccg cgacggagct gactccgccg 3242341 gaagcgatca ccgatttccc cgtttcctta gcaagctcga ccgtgctttt aacattgggg 3242401 cctgacagca ttccatctgt cgcgatgtca gtaaaaataa agacttccgc accttcattg 3242461 gctagctctt tgcccagttc agttgcctta agggttgatg tttcaagcca tccctctgtt 3242521 gaaacaaaac cgtttctcgc atccagtccg attgcaattt tctcgccata ttgtttcagc 3242581 atttttttga caaacggagg gttagaaact gctgagcttc ccaggatcac ccgctcgact 3242641 cctgctgata aatattcata gacgtcattt tcagaacgga tcccaccgcc gatttcgact 3242701 ttcaggttca gcttttgcgc aatctcaatc acatggcggt cattcactct tttcccttct 3242761 ttggccccgt cgagatcaac gagatggatc cattcggcac cctctttctc aaataactca 3242821 gccatgtcgt acggtgaatc gccatatatc gtttccttat tataatcccc ttgaacaagg 3242881 cgaacacatt tgccgtttct catatcaatt gccggatata atgtaaaagc actcattttt 3242941 tcaccttctg ttctgctgcc attttcgtaa attgggttaa aatagacatt ccgaccgtgc 3243001 tgcttttttc cggatgaaat tgggcgccga agacgtttct ttttccgact acagcaggca 3243061 ctcgtacacc ataatcggcg cttgccagaa gcgcgttctc ctccatcccg tcaatgtaat 3243121 aggaatgaac gaagtaagcg tagccttgtt ctgttttagt cagcagcgga gattcattat 3243181 gaaaagaaag acgattccag cccatatgcg gaaccttcag cttgtttcct ttttcatctt 3243241 ctgctttcag cctgactgct tttcctttta acagcccgag tcctgaagcg gtgccgtttt 3243301 cttcgctttc ttcaaataaa agctgcatgc cgaggcagat cccgagaagc agccttccct 3243361 ctgagaccat atcgtgaatc aattgatcaa gcttcgtgta gcccaaattg tccatcgcgt 3243421 ctccaaatga accgactccc ggcaaaatga aagcatcagc ttctttcagc tcctccggct 3243481 tttcagaaac aaaatacggc acgccgacac gttcaagcgc ctttgagaca ctgtataaat 3243541 tccccattcc gtaatctatc acgccgatca tttacagcat ccctttcgtt gacggtattc 3243601 ctttaactcg cggatcgatc gttgtcgctt catcaagcgc acgtcccagt gctttaaaaa 3243661 cggcttcaat catgtggtgg gtatttgttc cataatgaac gatgacgtgc aggttcattc 3243721 gagcttcgag cgccagcttc cacaaaaatt catgtacaag ctccgtatcg aaagttccga 3243781 ctttagcagc cgggaaatca gcgcgcattt ctaagtgcgg ccggttgctt aaatcaatca 3243841 caacttgagc aagtgcctca tccatcggca caaacgccga tccgtagcgt ttgattcctt 3243901 ttttatcgcc caacgcttcg agcagcgcct gccctaagca gatgccgata tcttcagtcg 3243961 tgtggtgatc atctatatca acatcgcctt ttgcgttaat ggaaagatca aattggccgt 3244021 gtttcgtgaa taaatccaac atatgtgtca taaacggcac atctgtttta atatccgctt 3244081 gtcctccgcc gtctattgta aatgccagct caatatctgt ttcgtttgtt ttcctgacgc 3244141 gttccgcttt tctcatttag aaatcctccg ttctctcgct tcaattgatc tggcatgggc 3244201 ttctaaccct tccagtctgg caaaagccgc gatgctttcg gcatgttctt caaaggctga 3244261 ttgactgtaa gaaataatgc tcgatttctt ttgaaaatca gttacgttta atggacttga 3244321 aaatctggct gttccgtttg tcggaagcac atggttcggt ccggcaaaat aatcaccgac 3244381 aggctcaggg ctgtatctgc ctaagaaaat tgcacccgca tgtttgatac tgccaagcaa 3244441 agcttccgga gactgtgtta tgatttctaa atgctctggc gcgagtgtat tgacagtctc 3244501 aatcgcttct accattgttt ccgccacata tatacaaccg taatctctca ctgaagcttc 3244561 cgctatttct cttcgcggca aggtttccag ctgcttattc acctcggctg aaaccgtctc 3244621 ggccagcgcc atggaatctg tgacaaacac acatgagcta agcttatcgt gttccgcctg 3244681 tgacagcaga tcggctgcaa tttcgctcgg aatcgctgtt tcatcagcca gcacgacgat 3244741 ttcactcggt ccggcaatca tatcgatatc gacatcgccg aacacttctc gtttggcaag 3244801 cgcgacataa atgttgcccg gacccgtgat tttatccacc ggctcaatgg tttctgttcc 3244861 gtatgctaac gccgcaatcg cctgagcgcc gcccattttg taaatgtctt ttatgcccag 3244921 ctcggctgca gcaaccaaaa ctccaggaga cagcagaccg tcttttcccg gaggcgtgac 3244981 gagaacgatt ctttcaacgc ccgctacgag cgccggaatc acattcatca aaacagatga 3245041 aggatatgcg gccgttcccc ccggcacata tacaccggcg gaatccagcg ccgtcacttt 3245101 ctgccccagc attgtgccgt cctttctgtg ataaaaccag gaggattgca gctgtctttc 3245161 gtgatattcc ctaatatttt cgattgcctg cctaatcacc tgaagaagac gtgaatccag 3245221 tgaggtgtat gcctcctcaa attcttcttt tgtgaccagc gggctgtcta tttcgatgca 3245281 gtcaaatttc gccgtgtagc tgcgaaccgc ctgatcaccg tttgctttaa catcttcaat 3245341 aatggaccgg accgtctttc tttgctcttc cgttccggca tcgatggaac gcttgagaga 3245401 aagccgttcc gctccgctga tggttttgat cttcattttg ccgtctctcc ttccacaacg 3245461 agagataggc gggatgccat ttcgtcaatc acatcgtctt tcatgcgata gcttaccggg 3245521 ttgacaataa agcgagaggt aatgtcacaa atgtgctccg tttcaacaag cccattttct 3245581 ttcagcgtct gtcctgtgga aacaatgtcc actatccgat ctgcaagccc aatgagcgga 3245641 gccagttcaa ttgaaccgtt gagcttaata atctcgactt gttctccctg ctctctgaaa 3245701 taactggaag ccacattcgg atactttgtc gcgattcttg gcgctactcc gctccagtct 3245761 gtattcggaa gtccggcgac agctaagtgg catttgctga tgtttaaatc cagtacctca 3245821 tacacatcgc gttcctcctc cagcatgaca tccttgcccg caattccgac gtctgccacg 3245881 ccatgctcca catacgtggt tacgtccatc ggcttcgcta atataaaccg aagattttcc 3245941 tccggcacat cgatgatcag ttttctcgaa tcttcaaact cctcagggag cctgtagcct 3246001 gcctgcctca gcagccctgc cgcttcttca aatatccggc cctttggcat cgccattgtg 3246061 agtaacttac ccattttgct cttcctttct ggcaccgata aaataagtga cgtttgcaaa 3246121 agattttgtc atctggtcga tattttctat tcccgataaa tcttgaagaa ccactttgtt 3246181 ccctttcatg cgttcttcat tcgcataagc gatggcttgc gcccgctgct ctttgctgaa 3246241 aataacagcg tctatttcac aaggttcgtc cttcatatga agggcttcaa tcagccggtc 3246301 gatccgaagc ccgaagcctg ttgccggtgc aggtgaatca aaatggccca gcagcttgtt 3246361 gtaacggccg ccgcttccaa tgacaaaacc gacattctcg gcgtacactt caaataaaat 3246421 ccctgtgtaa tagctcatgt ggctgaccat attcagatcc aggcggacat tttccgtaca 3246481 tccgtaatcc tcaagaatgt cccacagcgc cttcagctca tcaaccacgc tttttccttg 3246541 cgcagaatcg acgatttcct cggcacgtcc gcatacttct ataccgcccc gcagttcaag 3246601 gagctcaagc agcctgcttt tatcaatgga ggaaagcggg agagacttga catgctctct 3246661 gtagccgacg tagttctttt catataagaa cctccgcagc acatcagctc gttcaacgtt 3246721 tccgagcacc tcaacaaaca aagcatccgc aatgccggca tggccaattg caattttaaa 3246781 ggatgccagc ccagcgtttt ttaatgcccc gacgactaaa gcaatgacct ccgcatccgc 3246841 gctcgtcgtg ccgtcaccga ttaactccac tccgacctgc tcgaactcag ccggacgtcc 3246901 gccttcacgc tcctgagccc tgaatacatt tgccgcatag ccgactctta gcggatgacc 3246961 gtgtttcaga agcttcgatg ccgccaccct tgcaatcggc cccgtcatat ccgggcgaag 3247021 caccaatgtc ttgccgtcct gatcaagtag cttaaacagc tgctgctctt caattgctga 3247081 ctggacgcca acggtatcgt aaaactccag tgtcggcgtt tccataaatt gatatcccca 3247141 tttatcaatc aaatcggtta acgatcgtct cacctttttt ttcgtttcgt ataaaccggg 3247201 cagtgtatct ctcatgccgt gcggtttttc aaacataaac atcaacccga gcacctccgc 3247261 tgttatctta tgaaggaaaa ttccgaatcc tttagttcgc taatatgata atatgttagc 3247321 agatgaaaga atgaaaatca acgcttaact tcagtaagga tatttttagt tcaaatatcc 3247381 ttctcctcat tatgaaaaaa tcatgaataa tgtattaaag gtacgtaata tctcaaattc 3247441 tttatgtttg gcatgctata atacaaatca aatagagaac aaggagataa agatgaaaac 3247501 actgcgaact ctatgtgtcc tgatgattct ttcaggcgtt atttttttcg gacttaaaat 3247561 agatgcaaaa gatatagata ttcctttttt gaacagcctt aaaaaagtgg tttctgatag 3247621 cgatacagac tcagctgcga atagcaaaaa ggagctgaag ggaagcgcaa aaccgctgga 3247681 tgtcatcctt tacaatcaaa tggacgcacc ccggctctat aacggctgtg aagtaacaag 3247741 ccttgcgatg gtgctgaatt atgcgggata cgacgtgaca aaaaataccc tggcaaatca 3247801 ggttgccaca gtgcctttga catacagcag cggattaaag ggtgatccga atgacggatt 3247861 tgtcggggat atggcgaatg gccctggtct cggtgtctac catcgaccga tctatcagct 3247921 ggcgaaaacc tatgcgggag acaaagtgtc tgatctgact ggaaaaagta tttccgctgt 3247981 ttatcagcag cttgaaaaag gcaatccagt ttgggttatt acgacagcca actttacgcc 3248041 agttgacaac atgcagacat ggaaaacgcc aaacggaacg atagaaatta cgtacagcga 3248101 acacagcgtc gccgttacgg gatatgatga taaatatgtg tatctcaatg atccgtatgg 3248161 ctataaaaac agaaaaaccg atagaacaag ctttgaaaaa gcgtggaaac aaatgggcag 3248221 ccaggccgtg gttattcaaa agtaaacacc tgaagcctca ctatgctcta ttctgagcaa 3248281 atacgacaat attcatgctt tttgtatcaa tcggtaagat cgattcattt tccatttttc 3248341 acccaaaatt gtctttactt tcaggctgtc tgtttttatg attaaagcag attcagcctt 3248401 gccccgatct atgcgagaga agccggtgca agtcgctgac gcttctcttg caaaaaatga 3248461 aagatatccg gggaggattt atcattgaaa aaaatcgtgt ctatcctatt tatgttcggt 3248521 ttggttatgg gtttcagcca gtttcagcca tcaaccgttt ttgcagctga caaagtggtg 3248581 cacgaaacaa ttatcgtacc aaaaaataca acatatgacg ggaaaggaca gcggtttgtg 3248641 gcagggaaag aattaggtga cggaagccag tcagaaaacc aagaccctgt ttttcgtgtg 3248701 gaggatggag caaccctgaa aaatgtggtg cttggtgcac ctgcagctga tggcgtgcac 3248761 acttatggaa acgttaacat tcagaatgtg aaatgggaag atgttggtga ggatgcgtta 3248821 acggtgaaga aggaaggaaa agtgacgatc gacggcggtt ctgctcaaaa agcgtcagat 3248881 aagatattcc aaatcaataa agccagtacc ttcacagtga aaaatttcac ggcggataat 3248941 ggcgggaagt tcattagaca gcttggtggt tcaaccttcc acgttgatgt gatcatcgac 3249001 aagtgcacca tcacaaacat gaaggaagcg atattccgga cggacagcaa aacaagcacg 3249061 gtcagaatga caaatacacg ctactctaat gtcggtcaaa aatggattgg tgttcagcat 3249121 atttacgaaa acaacaacac tcaattttaa caaaaaaagt ccgctgatgt tattcagcgg 3249181 actttttcaa tctttcttgc atttcttcct tcgtatagat gatcctcatc ggatttccgc 3249241 cgacaaatgc cccgtcaggc acatccttat ggacaagcgt tccggcggac acaactgcgc 3249301 catctcctat tttcaccccg ggcagaatgg tcgtgttggc accaatcatc acttcgtccc 3249361 cgatcagaac tttgccgatc cggtattcgt gaatcaaata ctcatgggcc agaatggtcg 3249421 tattgtaccc gatgattgta tttgttccga ctgagatctt ttccggaaac atgatatctg 3249481 gcatcaccat gagggcaaag gatgtctgtt ttccaacctt catccgcaga aatgtgcggt 3249541 acagccagtt tttcatccct ataaacggcg tatatctcgc aatttgaatg acaatgaaat 3249601 ttttgacgac ctttaaaaaa ggtaccgttt gatagacatg ccacagtgag ttggcccccg 3249661 agaccggatg acgatctgtt tttctcacag attacttcac tccaacgatt tgtaatagat 3249721 cactcatttt ctcaagcata aaatccggct catgcttcgc cagcatttcc ggccctttaa 3249781 tcgtccatgc gactcctgcc gtttttgtac cggcgttttt ccctgccagc acatcatggt 3249841 aattatcacc gaccataatg gcttccgccg gctcgcttcc tagctgtttc agcgctaaca 3249901 gcacaggctc gggatcaggc tttgcattcg tcacatcatc aagggtgaca actgtttcaa 3249961 agaattcgcc gattcccgtg agcttgaggc ccatattgac agtatctctt aattttgttg 3250021 tcacaattcc taatgtaaag ccggcttttt ttaatgcatc cagggtctca tataccgttt 3250081 catattcagt gacgagtgaa tcatgcatgt catgattgta cgctctgtac atagcgatca 3250141 tatcctcgca tttatcaggg tccatcgaag agaacgtatc aaaaagagac ggcccgataa 3250201 atgcaaggac atcttctcgt ttatacttgc tcggataata atgctccagt gtatgcaaaa 3250261 aggacgcgat aattaattca ttcgtattaa taagcgttcc gtctaaatca aacagaatcg 3250321 tcgttacttg tttgtcactc atattgcttc ctttccaacc gctgagggtt tccatttttt 3250381 ccacgtgtgc gcaatagcca ttgtcagcag aactgctgtg gtgacacgaa tcaaaagaag 3250441 cggccagacc ggtatgccaa gcggaataaa gacaagtgta tcttccacga ccgcgtggca 3250501 ggcaacgaga aatataaatg ccaatgtcat gtcccgcttg ctcacgccgt catcctcgac 3250561 agctttgatc atgacacccg ctccgtaggc cagaccaatc gtcagtcccg tcaccatcgt 3250621 catagacgta tttttattca tgccaagcag ctgcgtaaac ggcgacagcc acctggaaaa 3250681 ccgataaagc cagcctaaat ctcttaaaaa ctggatgata atcatcagcg ggatcactat 3250741 tgccgccagc tgcaaaacac caagtccggc tttcgttaat gcttctgcca acattcctag 3250801 ccagctgtct ggcgccgcgc tcttcgcagc gataaaaccg tactgcgccg tttcctttcc 3250861 gccatgccaa atgaggttga tgacgatggc tgacacagcg gccaaaccga tgcgcacggc 3250921 caatatgacg ccaattctga taccaacctt tgcggcaact gtcgattcga taatcaagtt 3250981 atgacagaaa gaaagcataa cagctaaaat aaagacttct ttcacagata aatccaatgt 3251041 taaaatcccg gcaattcccg catacagatt cagcatattt cccagtacaa gcggaatggc 3251101 cgcttcacca gaaagcccga agagacccat taccggtgtg atcagccgta caagccaatc 3251161 catgacaggg gtatgctgga gcaaagtgac caatagcgtt accgggaaaa tcactttacc 3251221 cagcgtccat gttgtttgaa aacctgctgc aagaccggcc agaaagatct tcttcatccc 3251281 tcatccccct ttgttgacgt ctactccgcg taccgctcct tcgagtatcc cttgacgcgt 3251341 ctgaagatga tggctgccac agccaaaaca atcaatacga ttgaaatcac ctgagcgatg 3251401 cgaagtgaat cagtcagcat taagctgtca gtccgcattc cttcaataaa gtatcttccg 3251461 attgaatacc aaatgatata gatcaagaac atctcgcctc tacgcaaatt cgctctgcgc 3251521 agcagcagta aaacaatgac gccgacaaag ctccatagtg attcatataa aaaagtagga 3251581 tgataatatt gcccattgat atacatttga ttgatgataa attcaggcag gtgcaggttt 3251641 tctaaaaagg ctctgctgac agcctcgccg tgcgcttcct gattcatgaa gttcccccag 3251701 cggccgatcg cctggccgag caaaatgctg ggcgcggcaa tatccgcaag cttccagaac 3251761 gaaaggtttt tcactctcga aaacacataa cccgttaaaa tggcgccgat taatccgcca 3251821 tgaatggcaa tgccgccctt ccaaatctta atgatttctc ccggatgtgc cgcataatag 3251881 tcccattcaa aggcaacata ataaattcgt gcgcaaataa tcgcaattgg aatggcaaac 3251941 aggacaagat caataaacgt atctttctgc agcccccgtt tttcactttc cctcatcgct 3252001 atccacagcc cgagcaaagc gccgagaccg ataatgattc cgtaccagtg gacggctaac 3252061 ggccccagct gaaatgctat cggattgagt ggttctatcg cttcattcat ttaacgccaa 3252121 ctcctattct tcttgttcac cgtcttcaat gacgtccgcc agcttgttgg taaattgttc 3252181 agcggcattc agccccatcc gcttcaatct gaagttcatt gctgccactt cgatgatgac 3252241 tgcaagattt cggcctgggc ggacgggaat cgtcagtttt gtaatttctg tatcaatgat 3252301 tttcatggtc tcttcctcaa gtccgagccg gtcgtattgc ttgccctgct cccagagttc 3252361 aagattcatg acaatcgtga ttcgtttatt gcttctgacc gcgccagcgc caaatagcgt 3252421 catcacattg ataatgccaa ggcccctgat ctcaagaagg tgctcaatta attccggagc 3252481 gtttcccaca agagtatcct gatcctcctg ccgtatttca acgcaatcat cggcaacaag 3252541 gcgatgccct cttttcacaa gctctagcgc tgtttcgctt tttccgacgc cgctttttcc 3252601 tgtgatcagc acgccgacac catatatatc gacaagaacg ccatgaattg ctgtggtagg 3252661 cgccagcctg ctctcaagga agttggttaa acggcttgac agtcttgtcg ttttcagcgg 3252721 cgatctgagg acaggcaccc catttttctc ggaggcgtca atcagctcct gcgggatggg 3252781 catatctcta gaaagaataa tagctggtgt tacatcagtg cacagagaat ccattcgctg 3252841 ctttttctcc tcttcaggaa gctgttcaaa gaaagaaagc tctgtttttc cgagaagctg 3252901 cacgcgctcc ctcgggtaat atgtaaaata tccggcaatt tcaatacctg gtcttgatag 3252961 gtcactcatt gtaatcgggc ggttaattcc ttcttctccg ctgattaatt ccaaattgaa 3253021 ctgttccatt acgtcttttg tgcgaacctt tgccacgata tgttcctcct gttccgggct 3253081 gccccgagct tgctcacaat actttcattt tatcactttc gggcttgaac ctaaaacaga 3253141 ttttataaaa ggggggaaaa cacctcagct ggtctagatc actagtctga aaaagagtaa 3253201 aataaaggta ttcaaattcc agaaaggcgg atcatctatg gcagagagtc ttcttatcaa 3253261 agacattgcg atcgtgacag aaaatgaagt aatcaaaaac ggctatgtcg gaatcaatga 3253321 cggaaaaatc agcacagttt caacagaacg gcccaaggag ccatattcaa aagagattca 3253381 agcacctgcg gattccgttt tgcttcccgg catgattgac attcatatcc acggcggcta 3253441 tggcgcagat acaatggatg ctagcttttc cacgctcgac atcatgtcgt caagactgcc 3253501 cgaagaaggc acgacgagct ttttagccac aacgattacc caagagcatg ggaacatttc 3253561 tcaagctttg gtgaacgcaa gagagtggaa agcggctgaa gagtcctctt tattaggtgc 3253621 agaactgctc ggcattcatt tagagggccc ctttgtttcg cctaaaagag ccggagcgca 3253681 gccaaaggag tggattaggc cttcggatgt tgagcttttc aaaaagtggc agcaggaggc 3253741 gggcggactg atcaaaattg ttacacttgc gccggaggag gatcagcatt ttgaactgat 3253801 ccgccatttg aaagacgaat cgattatcgc atccatgggg cacacggatg ccgattccgc 3253861 attgctgtcg gatgccgcaa aagcaggggc gagccatatg actcatctgt acaacgcgat 3253921 gagcccgttt catcaccgag agcccggagt gatcggaacg gcgctggccc atgatgggtt 3253981 tgtgacagag cttatcgccg atggcattca ctcccatcct ttagctgcaa agcttgcttt 3254041 tttggcgaaa ggcagcagca agctcatttt aattaccgat tccatgaggg caaaaggact 3254101 gaaagacggc gtatatgagt tcggcggcca aagtgtgacg gtaagaggac gaacagcact 3254161 tctttcagac ggaacccttg ccggttcgat cctcaaaatg aacgaaggcg cacggcatat 3254221 gcgtgagttt acaaattgct cttggacgga tatagctaat ataacttctg aaaacgcggc 3254281 caaacagctg ggcatctttg accgaaaagg cagtgtgact gtgggaaaag atgcagattt 3254341 ggtgattgtc agcagtgatt gcgaggtgat tctcaccatt tgccgcggaa acattgcatt 3254401 tatatccaag gaggctgacc agatatgaaa gtaatggaat gtcaaacgta tgaagagcta 3254461 agccaaatag cagccagaat aacggcagat acaatcaaag aaaaacctga tgctgttctc 3254521 ggtttagcga cgggcggcac accggaaggc acgtatcgcc agctgatccg cctgcaccaa 3254581 actgagaatc tctcatttca aaacatcact acagttaatt tggatgagta cgccggactt 3254641 tcaagcgatg acccgaacag ctatcacttc tatatgaacg accgtttttt tcagcatatc 3254701 gacagcaagc ctagccggca ttttattccg aatggaaatg cagacgattt ggaggccgaa 3254761 tgcagacggt atgaacagct agtcgattcc ctcggcgaca ctgacattca gcttctcggc 3254821 atcggccgaa acggacacat cggctttaac gaaccgggaa cgtctttcaa gtcgcgaact 3254881 catgttgtga cattaaatga gcaaacccgc caagcgaatg ccagatattt tccctccata 3254941 gacagcgtgc cgaaaaaagc actgacaatg ggaattcaaa cgatactctc aagcaagcgc 3255001 attctgctgc ttatttctgg aaaaagcaaa gcggaagctg ttcgtaagct gttagaagga 3255061 aacataagcg aagattttcc cgcatctgct ttgcacctgc attccgatgt tacggttttg 3255121 attgatcgtg aagccgcgtc attaagacct tgaaaggaac atgctgactt atgaatatca 3255181 ataaacaatc gcctattccg atttactatc agattatgga gcaattaaaa acccaaatta 3255241 agaacggaga gctgcagccg gatatgcctc ttccttctga gcgcgaatat gccgaacaat 3255301 tcgggatcag ccggatgaca gttcgccagg cgctttctaa tttagttaat gaaggcttgc 3255361 tctatcgcct gaaagggcgg ggcacctttg tcagcaagcc aaaaatggaa caagcacttc 3255421 aagggctgac aagctttacc gaggatatga aaagccgcgg gatgacaccg ggcagcaggc 3255481 tcattgatta tcagcttatt gattcaactg aggagctcgc ggctatatta ggctgcgggc 3255541 acccctcctc tatccataaa atcactcggg tgcggctggc aaatgatatt ccgatggcga 3255601 ttgagtcctc acatattccg tttgagcttg cgggtgaatt gaacgaatcg cattttcagt 3255661 cgtcgatcta tgatcatatt gaaaggtaca acagcatacc gatttcccgt gcaaaacagg 3255721 agcttgagcc aagcgctgcc accacggaag aagcgaatat tcttggtatt caaaagggag 3255781 cgcctgtcct attaattaaa cgaacaacat atctgcagaa cggaactgct tttgagcatg 3255841 caaaatccgt atacagaggc gaccgttata catttgtcca ctatatggat cgtctttcat 3255901 aaaaaaagcc tccaaccctt tttaaggatt ggagacatgg cgaaaatcaa actggtctgg 3255961 tgccggacga tatgtttctt ttttcgtctt gaacttccag atcggtgatt tcgttttgcc 3256021 gttaaaactg tcttccacta taatgtacca ataataaaca gactgcggtt caagatgatc 3256081 ccagcggaat tcagctgtgt ccccgctctt cacttgctcc cgttttccga gctcttcatt 3256141 ggtatatacg ttacattcaa aataatcggt ttccaccttt ttgattcttg gcttcaaatc 3256201 aagcgaaagg gaaaattcat ccttgttgcc ataggtatcc gtatcatagt agttcttatc 3256261 ctttacatac ggagagtacg tcgatacgtg caccatgtca ttggcttggt caaattgaag 3256321 caaacgcaaa tacccttggc cgccttctgg cccgccctga taatcggcca gcatttgatg 3256381 cacaagacga tccggtttcc catcaccatc atcatccagc tcatctgttt ttctcatcgc 3256441 actatgataa tgcccgctca acaccatcac gacattcggg ttcggcttta cgatttcttt 3256501 gaatattttc tctccgattg ggcttctgtt tccgctgacc agcaaatact catgaaaagc 3256561 taaaatggcc atccggtcag gatgcttctt cagcacctga ttcatccacg cgatgtcttc 3256621 atccgtaatg ccccatccca tgtacagcat gatataatca ttgccgttgc tagaaatcag 3256681 gtcataatgt ccgcggttat ttttatagga accgccataa tgaaattttt tatcaaaacg 3256741 atcgctgcca aaatatttgc caaacgccct gtaggagccg tccttatgtc cgacatcgtg 3256801 attgccggcc agcacgccgt aaggaattcc gctcttatcc agaacggaca ttgaccgatc 3256861 agcgtttttc cactgtctga tatcggcgga atcatctaca atatcacccg tgtggaacac 3256921 atatttgata ttgagctgct tttgattatc ttttatccat tcggtctgtt tatcaaaaat 3256981 atgcggatag ctttcggcgt aatactgtgt atcagacatc cagacaaatg tgtacatatc 3257041 cttcgcagga ggaatttcat cctgtacaat cacattcatt ttcgactccc gtacaaaatc 3257101 ggcggcaatc acagacgctt tcagcgtaaa cggtttgtca tccttcgcga cgaagctgtc 3257161 aacaggctgc cattcgtttg tccgataatt ccaagcatac atcgtcacct ttctccccgg 3257221 caaagaactg cccttccaga ctgattctgc cagatcattc tcatcaattg atggatcaac 3257281 cgtcacttca aagcgatgat aagggaaaag ctctttgttt tctgtcgata ctgtttttcc 3257341 atcagcagct gatacccgct ccaattcttt attcgtaaat ggggtctccc tttccggcac 3257401 aaagcttttc ggcggttcag tcagtgacgc gtgcttaaat attttcacat gattgcgcgc 3257461 tgtatattga aatcccctat aaaaaccaac atccatggca tcattcgtcg gatctttcac 3257521 ccgtacagaa agcttggcct tatgcgtgtc ggcttcgctg tctataacct ccggctggtc 3257581 cggatgctct cgttcggttt taaatatcct ctcaatcact gttttattgc ccgcgagatc 3257641 cgttgctgtc acttttagag aatgttttcc cggcaaaagg tcagaagatg acgtatgata 3257701 tgggagtgta atgctttctc catctaacga cgcctccgct tcctcaattc tgctccattt 3257761 atcatacata tccgcctgca ggataaggtt tcctttatac gtttgcccct cggtgatatt 3257821 cggctcaatg tgaggtcctg aattatctac ccgtacaacc aggctgacat tttccttccc 3257881 gtcgcttgct tgaatatggt gagcgccttc agaaagcttt gatgtatccc actccagcag 3257941 ctgtgatgta aatagtccgt caggcagatt gaactgaaat tgccagcttt tattcgagcg 3258001 ctgattatcg ccaataaaga gttccttctc aggagacacc ctctgatctc tgatcaccgt 3258061 tccatccgat aacaccaatc gggcgttttt gactaagaag tcatcacggt tttcagccgt 3258121 atcaaacgga gacaccttcg aacctgaacg tatcgtaata cgctgcagct gcttcccttt 3258181 ccgaagcagt gtctctggca atggaacaga ataggtgcgg tatttatttg ttgtatcatc 3258241 gaacaccttc agcactttgc cttccatcgt taccgcgttt ttaaaataaa ggttcgtttt 3258301 cctcgtatcg aatgcaaaat atacttcttt ttccatcgcg ggctctgtca cttgtttttt 3258361 cccgtcaatc catagcttaa tgctgtcagc tcgcccttct gtcgtggctt tgagaaattg 3258421 agttcccgac agcgtgtctc tgttttcaat attcatccgc agaccgtgcg ccttgcttgt 3258481 ttgtttaata tcaatcattt tgaccggcgt tctcgcttca ttgatcccgt ccccggccgc 3258541 cacataatac tctagctgat ccttcccgat caattcaggc gaatacacaa tataatggaa 3258601 gagattatcg ttgcggtctt tttcagcaag aattcgctta aacggtttgt tctcatccgt 3258661 ccggtagtaa aaggccactg ttttcactag gcttcggtcc cgtatgtcag cccgcagctc 3258721 aatgctttca gcagggcgga caggcttgcg gtcagtcaaa tcctcaatga ccggcttttc 3258781 tttatcgagc ttgattttcc gtttctggtc gggcacctgt gcctgtaata cggttccggg 3258841 agacggattc ttttccccga ttgaaatgtt cagaagttct gctgttccgt tcagtggata 3258901 cttataaagc actgatgaca gccggcgcag cgcatgtttc cgataatgcg caaccgaaat 3258961 gtcctttcct gtattcgttg atatcacaac ggcccgcggc ctcgtattgg ccataccctc 3259021 tgtctcgtct atcaccgcaa gattttttcc ttcttttagt tgtgtctgat aataacgatt 3259081 gaaatccgct gacgtcaatt ctggatgccc ggcaggcttc agccagacga caaacgtttc 3259141 gccggatggt atcaagatcc tttcatcagg tctccaaatc agatcggagt caggcccttc 3259201 ttttgggtag cggtaacgga tatggtagtc tttaaaatca atcgttctgt cagtcgtatt 3259261 aaaaatctca ataaattcat aaccgtctgc gcgtcctata ttcttcgtat caaccgccag 3259321 ctctgtgatc agaagctccg gaatatgggc aaggtcagcc tggtatcctt caagcttcag 3259381 tttcttcgtc tccgactcaa cccgctgctt cccattcgac atcacaatgt aatactcaag 3259441 ctcgctgttc caaatcaaac gtttcggaat ttgtgccaaa aacttgcgga ccgctccggg 3259501 ggtcgggtcc atcggcacca ttttgtagcc cagctcatta ctttgtttat aaaaaagaaa 3259561 ggcggaaaat gcttgatacg aattatcgcg aacttgagcc tcaatcatta gattgcttct 3259621 catttcagct ttcacatcaa tttgaggagg attttcaagc aagggtatgt aatgaggcgt 3259681 ttgaaatagt tcctgctgta caacaggaaa agctttcgat tcatgatggc cgccagacaa 3259741 aacggaaaga aaagacagta atatagaagc aataaccgtg tatttcctca tcaaagcacc 3259801 tcccttttca tgtattttgc gtctgaacag ggaagcttat gagttcattt ttgtgcataa 3259861 agaacaaaaa aacgtctgtc tcttgaaaat tccactatta cccagtaaac taaggatagt 3259921 taaccagtta acaattaaat cagagaggca aattgatgga caacagcatt catgatgaat 3259981 tatttcaagc tatacaacaa ttcgcattaa aaagggataa acgcgtctgg caaaaggtgc 3260041 agataccatc cattggcata tcctcacaac atcacgatca cctcaaaaaa gactggactt 3260101 tgacccagct tcacattgtt tcctgcatac ataccagcca aaatgtgaac aacagcttct 3260161 tagcatcccg tttacacatc tcaaaagccg ctgtttcaaa agcggttcat gctttgttga 3260221 aacacaatat cattacagtg acaaaaaagc ctggcaacaa aaaagaaatt ttttatacgc 3260281 taactgatag cggcagaaaa ttggcggcat tacatgaaca gcttcatgag aaagcaaagg 3260341 agcaatataa acagcttttc aatgaatttt caattgatga tttaaaaaca gtgactgcgt 3260401 ttttcaactt gtggatcaaa tatatgtaaa aagagtctca cccgcatggg agagaccttt 3260461 ggaattctat tatgccccgt caaacgcaac gagaagtgaa acaggtccgc gtgtatacag 3260521 accggactca gcataacaaa aatcttcctc taatctgata ttccgcatct tatccagcac 3260581 aatattagct acaatttcga tttcgttttt ggcaaaagct gctcctacac agttatgaat 3260641 gccggatccg aaagcgagat gccgggcggc gccgctaaaa gcgctcttga taccaagatc 3260701 ttcccgatga atattaaaca cgtcaggctg ttcaaatgct tcagggtccc ggttagccgc 3260761 accgatcata caaaaaacaa tcgtatcttt tttgatttcc ataccgccga ccactgtatc 3260821 ttgggacagc tgccgcggaa tcagctgaac cggcggttta taacgcaatg tctccgcaat 3260881 ggctctcgga actaacgaac ggtcagccaa aacatcattc atctgctcag gattgttgag 3260941 caaatggtag atcatcagtg ccagcgtctt atcagccggt tccgttgcgg ctaacagcac 3261001 attaagaatc agtgcgagta tatccttgtc cgacagcgcc atgccttcat attcagaagt 3261061 acataggatc gaaattaaat ctgatcccgg attgacgcga cgttctttaa tgaccggcat 3261121 caagtattgg gaaagctgtt cgctgcacca taacgaatgt gcccgcgctt caggagattg 3261181 agagatactc gtgataaaat cggcaactcc gctgtgccac tcagagattt tttcatggtc 3261241 tcttttatcc agcccgagca tgtccatcgt gacgcacacc gcaaacgtct ttccaaaatc 3261301 attgacgaga tcacttttcc ctctttcaag ataaggcgct aacaagtttt ctgcattttg 3261361 tttaatcaat ggagacagat gatccagtgc gtcaccgata aagcttctca ctacaattct 3261421 tcttttggca gagtgttctt ttccatgcat ttgggccagc acagggcctc gcatgactgg 3261481 ttcggcacgc tcaacaagtg atttcgtcgt gaagatatcc ggatgctgaa ggatatagcg 3261541 gacatcatga tagcggctga taaaataact gtctatcgac tcttcataat gaaccggatc 3261601 ttcctcccgc agttgtgaaa aataagcata tggattgttt tgaaattgat cagaaagcac 3261661 actaaacaat ttaatcgatt ggctcatgtt ttactccccc tatcatcctt cagatgtgat 3261721 ccgtttctca gaaagcatct gcgccatttc ctgtacaatg agataccctt gattcggccg 3261781 catacaaata gaaaattcat ggttactgat cttctcaccc agcttccacg gacgatgata 3261841 agcaaggagt gtctcttcca cctctaaaat atccggagct ccgataaaaa acggcagctc 3261901 agctatgaca tattccacag ccaaattcag catatcctca ctgacttctt ccatcatcaa 3261961 actgacgccc cgcgcacgcc cgattatcgc ttcacgagac atgtccaaac aagcatgtcg 3262021 aaaatgaggc tgctcaaaaa atgcatgttc aacttcttgt ctcaacagct ggtaggcttt 3262081 gttatctata aaatcagaaa atgtatgaat cgccttcgga tccccgccat gagccacaag 3262141 ggctctttct gcaaatctcc tgtttcgtga tacctctttc cttacttttc gttcagcctt 3262201 tcctctcgga gttccaagcg cttctagaag attagccgcc tcatgccctg caagtaaaac 3262261 tgaaacgctt ttaaattgag ctttcgccca tccaattaat ctgtaaatat aatcctctga 3262321 aaacctgctg ttaaatgggc tgatccccac caaaacatgc ctgcgccgtt caaatatttc 3262381 tctgcagttt tctgttaatg cctcagcaat aaaatgcaca gaccttcttt ccgttaccat 3262441 tccggtcatc tcattcaccc ctaaaactta tcccgcttta agtcatcacc ctcaaataca 3262501 agatggaata gctagaacaa ctgaacaaga cgaatggcag gcatcactta aagtttccaa 3262561 atgtttttta agattttaat aatcattttc aatacccata tcatgataaa tgtttactag 3262621 taaacattag tcattttatc ccttttcctt ccaaacgtca atatgatctg tgcccaaata 3262681 tttgaaaata aatgtaaaca tcacattttc cacacacttt ttacacgcat attcagcatg 3262741 acatatcaac aaatagtcta aacaccaaca attgacaacg aaaacaagaa aagataaaat 3262801 aaaattgttc accagtaaac gatttgtttt attgtttcat cgtaaactat tattcctaag 3262861 aaagaaggta gcctatgtct gatttgacaa aacagatgat atacgacata tacgtgagac 3262921 tgctgcacct taatgaacaa aaagcgaaca cttcacttca gcaatttttt aaggaggccg 3262981 cagaagagga tgtagctgaa attcccaaaa atatgacaag cattcacgtc attgactgca 3263041 tcggccagca tgaacccatt aataatgccg gaattgccag aaaaatgaac ttatcgaaag 3263101 cgaatgtaac gaaaatcagc acaaaactga tcaaggaaga attcattaac agctatcagc 3263161 tgacagataa caaaaaagaa gtttatttta aattaacccg taaaggcaga cggattttcg 3263221 acttacatga gaaactgcat aaaaaaaagg agctggcttt ttaccaattc ctcgattcat 3263281 tttcacaaga agaacaaaag gctgtattga agtttctaga gcagttgacg tcaacacttg 3263341 aagcagaaca aaccgatggg actccagaca aacctgtaaa gtaaacaaaa aggcggtgta 3263401 cactttggct catacaaaat caaaggcagt attgatctta tacactgttt gcttcagtgc 3263461 attttttgca tctttaagcc agaacattta ttcacctatt cttccgatca ttaaagaatc 3263521 attccatgtt tccacagcta tggtgaacct gtcagtctca gtttttatga ttgtgacagc 3263581 aataatgcaa attatattag gagcgatcat tgattttaaa ggcgctcgga tcgtcttgat 3263641 taccggtatt ctggcaacgg cagcagccag catcggctgt gcggtgacta ctgactttac 3263701 cttgtttctg atattcagaa tgatacaggc agccggttcc gcagcactgc ctcttattgc 3263761 tgccacaacg atcggacagc tgtttacagg aaatgaacgc gggagtgcaa tgggaacgta 3263821 tcaaatgctc ctgtctgtcg caccggctat tgctccagtt ctaggaggat tcataggcgg 3263881 agcagccgga tacgaaggga ttttttggat acttgcggcc atctctatcg ttttgctggt 3263941 gacaaacagc atcacctttc ctaaagattc tccaactgaa tctatgcagc aagccaaagg 3264001 caatgtgttc gctcattata aatcaatatt tacaaatcga acagggaacg tcattttgac 3264061 tttaagtttt gttctctttt tcatttattt tgcagtaatt gtctacctcc caatattgct 3264121 gacagagcat taccatatag atgtgggtat agcaggactg ttatatttgc cgctggcgct 3264181 gagcacgatt gcaggtacgt ttctgtttaa aagaatacag gcaaaaatcg ggctgcacac 3264241 cttgtttatc ggaagcaatg tgattgccgc ctgcagcatc attttatttg ctgttacaca 3264301 ttccgtttct ctcgttctca tggctctgac gctggcactg tttggcatct cgatgggggt 3264361 tattcctccc ttgtactcta caatgattac taatgaattt gagcacaaca gagggagtgc 3264421 aatcggaatg tttaacttta tccgatatac aggcatggca gcaggtccga tggtatctgc 3264481 ctacttgctc acaatgatgc cgtctgccat gtcctttagc ctcctaggcc ttggatttgc 3264541 cgcattgagc ttttgccttc ttccgccaat gttttcgccg cagaagcgca cgaaacaaaa 3264601 aaagcaccac atgtaaaaaa gctgcctttg cgggcagctt tttttatttt tttctaagcg 3264661 gctctaaaat gcctttttga atcagcaaat ggaagaccga caggataacg gatgcccata 3264721 tcgctgtgcc gaagccgtcg atttgaaagc tgtcacccat aatggacgcg gtcatcataa 3264781 gcgtgatggc gttaatcaca aacaagaaga gtccaagcgt caccatggtg accggcagtg 3264841 taaatataat taaaagcggt ttaatcagca cgtttaagat cgataaaatg aggctggcga 3264901 taatcgctgc cccaatgctg ctgatatgga tggagtcaat atatccatca atgacgatta 3264961 ataacaatgc attgactaaa atgctgactg cccattttac catgtcattt catatccctt 3265021 tctgacggga cgataaaaat ccaaatgata taaatgagca aaaccggcaa gacacttgtc 3265081 ataatggcta agatgacagt tatgactctg aggagtgatg cgtcccaatt gaaatattcc 3265141 gcgagacctc cgataacacc ggcgattttc ttattttttt ctgagcgata aagcttattc 3265201 attcgatcac ctctgtgagt actttagttt gatggcgcct gttagtgatt ctgagaagac 3265261 ggtgatgttt tgatcatgtg cctgatttga agtgaacatc atttcttttt gaatcgtatc 3265321 atttttttcc ttcagcatct ctacatccat taattcatgg gacagcgtac caagattgct 3265381 tttcagctct gccttcactg cgagatcgtc cggaattgca agctctacat ttccagtcgt 3265441 tgtttttgca taaatggagc ggcagtctga ttctgttacg ttaatcgcaa tatttccgtt 3265501 aaagctttga acgtcaatgg attcgctttt ccctcggaga tcgatcaatc cgttaatggt 3265561 ttccgcttct atcgtaccgc agctgtggct tgcgagctta atttgcccgt tggccgtttc 3265621 agctatggct ttttcggctg ttaaatacga gaacgacagc acgccgtttg tcgttttcgc 3265681 tgagaactct tttacatgta aatgttcccc tctgactgga ccgttaaaca gcttcacccg 3265741 aatcttatca tactccttct gaggaatata caaagtgaca ttcgttttca tcgtcttttt 3265801 ctcagtacgg ataaaaaact tattaccttt gatttcacat tcaatatgct gaagaaatgc 3265861 gtgtctcgcc gcatcctggc tgtcagcgcg atataccttc gcctggcatt ccgctctgat 3265921 atcgtcatct tcccaaggga cgatatttac gctgccattg gcaatttgca gctcaacact 3265981 ggaaaagtca gtatctttaa attgaaaaat gtgctgaaca tcatacgcat ggccaaagtt 3266041 taaatcaagg tcaacttcct tgaccttttt cacagcagaa tcaatccagt caaacagctt 3266101 ggctcctaaa gacggtttgc cgctttcttt ttttgccgtt gtaaatggct cttcctcgtc 3266161 atgaacgtga actgagagcg ctgtgatttt ctcttctttt tccttgtagt cgctgtcaag 3266221 cttttcaatc agtgtcaaag cttcttgtgc tgtaagcttt ccttcctcaa caagcttaag 3266281 gattcgttcc ttttcttgct tcattacgat ctcctcccca ttgtctactt atgctgcacg 3266341 caggacctta atgccctgaa tcacattcca aatgataatg ccaatgacaa ctaagaaata 3266401 aataaccgct cccccgatga ttacaaatac aggaagcaag ctgtctccat caatcgcaac 3266461 ggctccgcca agtaaagcaa taaaaaggaa cagccagccg acaaacggaa caatgtgaga 3266521 aataagagag cgtatcgcat ggcgttttgt ttctttctca tttacaacaa aatatgcgac 3266581 aatcggcaca atgattggcg caatgaacac actgaaataa caaagtgatg caataatagc 3266641 ttgattacgg ttcaattcat tccacactcc tattgtgaat tgtccatgac aaaagatcag 3266701 ggacgtttta cttatttata cgtttaaaat ctcttcaggt ttcaaattca ttctttagac 3266761 atgctccgat ttacggaaat tggattttaa aaagttttag aagtagaatc ttccggctat 3266821 accgattaca atatgtaaaa agcttacggc aaccaaggag gctggacaag caatggagaa 3266881 agatcccagt gactatacag taacacaaga atcagtgtta aagctgattc aggaacaaaa 3266941 aagaatgaat cgtgaaatga tcaccgagct tgagcagatt cacggaccct tcccgatctc 3267001 tcacgatatc caatatataa aagtgctgct cgacagcagc aacacacata ttgttcaaga 3267061 tttaatgagt gtaagtaagc agctgtataa gaagactttg taattgcgga aaacatatca 3267121 ttcattataa ctgaaacaaa gctaaaggtt agatgacaat atcttgcctt ttttgttttg 3267181 aaaaaacaag tgattccctg gctgtcacaa aatgattgta acaaaaaaag cctgccggca 3267241 catccagtta atggactctg tcggcaagct gtaactatca gaaagagata gccgttcaaa 3267301 attaacgtaa caattgaagc acgttttgcg gctgttggtt tgcttgagca agcatcgctt 3267361 gagaagcttg agaaggaatg ttgttctttg tgaactcgct catttctttc gccatgtcaa 3267421 cgtcacggat acgggactca gcagctgtca ggttttcaga agaagcacca aggttgttga 3267481 ttgtgtgctc tagacggttt tgtaccgcac caagtttagc acgttggttt gagacattgt 3267541 tgattgcagt atcaatactt tcaagttgtg tatcaaaagg agtattagca aaatctgtta 3267601 cattaagtgc gtttactcct aaagcagttg atgacatgct gtcaatgtta actgtaagct 3267661 gctggccagc atttgctcca atttggaaag tgaaaccatc agtttcagta ccatctaata 3267721 actttttgcc gttgaattca gtacgatttg aaatgccatc aacttcctca ataagcgcat 3267781 ccatttcatc tttaattgca ccaagatctt ctgcttgttg tgtacctgtg tttcctgctt 3267841 gaacagtaag ttcacttcta aacctattat gccgtaaaga aaaagcttgc ctgctaagcc 3267901 caaggatgga cttgccgaca agctgtcccc tcttaacaga gggttttaag atgtagctgt 3267961 ttcttttgct ttcaagagcg atttcatgcg tgttttgtca cgttcgataa caggctttaa 3268021 ataacggcct gtatacgatt cttcaacttc agtgatttcc tcaggcgttc cagacgcgac 3268081 aatggttccg cctccggctc cgccttccgg gcccaaatcc acaatgtaat cggccgtctt 3268141 aatgatatca agattgtgct caataaccag tacagtgtct ccgttgtcta ccaaccgttg 3268201 cagcacgaca agaagcctgg cgatatcgtc gacatgcaaa cctgtcgtcg gctcatctaa 3268261 aatgtagagc gtacgtccgg ttgagcgttt gtgcagctct gacgcgagct tcacgcgctg 3268321 cgcttctccg cctgacaagg tcgtcgccgg ctggccgagc gtaatataac ctaaaccaac 3268381 atcataaagg gtttggagct tgcgtttgat tttcgggata ttttcaaaga aagaaagagc 3268441 atcttcaacc gtcatatcaa gcacatcaga gatgcttttt cctttgtacg tcacttcaag 3268501 cgtttcacgg ttatagcgtt tgccgtgaca cacctcgcat ggaacgtata cgtcaggaag 3268561 gaagtgcatt tcaattttaa taatcccgtc tccgcggcag gcttcacatc gtccgccctt 3268621 cacgttgaag ctgaaacggc cttttttata gccgcggacc ttcgcttcat ttgtctgcgc 3268681 gaatacatca cgaatgtcat caaatacacc ggtgtatgtc gcagggttgg atctcggcgt 3268741 tcttccgatt ggcgcctggt caatgtcaat gactttatct aaatgatcca aacctttaat 3268801 ctctttatgg ctgccgggct tcgctttcgc tttatgaagc ttttgcgcca gcgccttatg 3268861 caaaatttca ttaacgagtg tactctttcc tgaaccggaa acacctgtaa ctgctgtaaa 3268921 cgtcccaagc gggaacttgg cattcacttt tttcaggttg ttttctgatg cacctttaat 3268981 ttcaatgtaa cgtccgtccg gctttcttct ttcaggaggc aatgggataa actttttccc 3269041 tgataaatag ctgcccgtta atgaatttgg atcttccatc acttcttccg gcgtacccgc 3269101 agatatcacc tgtccgccgt gaatgccggc tcccggtcca atatctatta aataatctgc 3269161 tgccatcatc gtgtcctcat catgttcgac aacaatcagc gtgttcccga ggtctctcat 3269221 atttttcaga gcgctgatca agcggtcgtt atcacgctga tgcagaccga tagacggctc 3269281 atctaaaata taaagcacac cggataaacg cgagccaatt tgagtcgcca gcctgatgcg 3269341 ctgcgcctct cctccggaca atgtacccgc tgccctgctc aatgtcaggt aatcgaggcc 3269401 gactttgtcc agaaagctta agcgctccac aatttcgcgc aaaatcaaat tggcgatctg 3269461 catatccttc tcagaaaggg taagatcttt aaagaaggca agtgcgtcgg cgacagacag 3269521 ctcggtaatt ttcccaatgt ggcggccgtc aatcagtacg gcaagcgcct ctttctttaa 3269581 ccgatagcct ttgcacgtcg gacaagactt ctgagacata tactgctcca tttgctcacg 3269641 tatgaaatcg gagcctgtct ccttatagcg tctttcaatg ttgcgcaata cgccttcaaa 3269701 ttgaatttca ccttcgcgga tttgtccaaa atcattttca tatcggaaat aaatcaggtc 3269761 atccccgctg ccgtacagca ctttatccag ttgatgcttc ggcaaatctt tgaccggcac 3269821 atccatatca atcccgtagt gggtgcagac tgcctcaagc agctgaggat aatattgtga 3269881 gctgatcggt gtccaagggg cgaccgcatt ctccttcaat gacaaatctt gattggggat 3269941 gacaagatcg gcatccactt caagcttcat tccgagaccg tcacacgtcg gacacgcccc 3270001 gaacggactg ttaaacgaaa acagacgcgg ctcaagctca ccaattgaaa atccgcagtg 3270061 cggacaggca tgatgctcgc tgaacatcag ctcttcctca ccgatgacat cgatcataac 3270121 ccgtccttca cctaaacgaa gcgccgtttc caatgaatct gacagccggg ctgccacgcc 3270181 ttctttcacg acaatccggt caatgactac ctcaatggaa tgcttcttgt tcttttctaa 3270241 ttcgatatcg tcggaaagct cagccatctc gccgtcaatt ctgactctga catagccttg 3270301 tttcctaatc tgttcaagca ctttgacatg agcgcctttt cggcccgaga caatcggcgc 3270361 cagcacctga agcttcgtcc gttccgggta ttccagaatt ctgtccacca tttgctcgat 3270421 ggtctgggat gtaatctcaa ttccgtgttc cggacaatga ggcttcccta ctctcgcata 3270481 taaaagacgc agataatcat aaatctcagt taccgtaccg acagtagacc tcggattgcg 3270541 gctcgttgtt ttctgatcaa tgctgatggc gggagagagc ccctcaattg catccacatc 3270601 cggcttatcc atttgcccta aaaactggcg ggcataggca gacagcgact cgacataccg 3270661 tctctgtcct tcagcatata tcgtgtcaaa ggcaagggag gatttacctg atccggacaa 3270721 acccgtgaca acgacaagct gatctctcgg aatcgttaca tctatatttt tcaggttatg 3270781 cgccctggct cccttcacct ctatccgatc catagccatt tgttcatcat ccttccgctt 3270841 ttagctctaa aagtaaatcg cgaagctccg cggctctctc aaagtcaagc gccttggcgg 3270901 cttccttcat ttcatgctcc atctgttcaa cgactttctg gcgttctttc ttcgtcattt 3270961 tcgacagctt cggcgcggct tttgttttgt attccgcttt atcctcagct gctactgtgg 3271021 cacgaatgac atcgcgaatt tctttattta tcgttttcgg cgtaatgccg tgctcttcgt 3271081 taaaccgctc ctgctgctcg cggcggcgtt ttgtttcatt aatcgcaatt tccatagact 3271141 tcgttatttt atcggcgtac ataatgacgc ggccttccgc atttctcgct gcccgtccga 3271201 tggtctggat cagcgaccgc tccgaacgaa ggaaaccttc cttatccgca tccaaaatcg 3271261 caacaaggga tacttcggga atgtccaaac cttccctcag caggttgatg ccgacaagca 3271321 catcgtactt gccaaggcgc aggtcgcgga taatttcaat ccgttcaagc gtcttgatct 3271381 cagaatgcag atagtttact ttaatgccga tttcctttaa ataatcggtc agatcctctg 3271441 acatcttctt cgtcaaagtt gtcacaagca cccgttcatt ccgctcgatt cttgcttgaa 3271501 tttcgccgat caagtcgtca atctgacctt cgattggacg gacgtcaata agcgggtcaa 3271561 gaagccccgt cggacgaatg atctgttcga ccatttcatc tgtatgttca atctcgtacg 3271621 gccctggtgt tgctgataca tacacgatat tgtgcatatg cttttcaaat tcctcaaaac 3271681 gaagcggacg gttatcaagc gctgatggaa gccggaagcc gtgatccacg agcacctgtt 3271741 tccgcgcctg gtctccgtta aacatgccgc gcacctgagg aattgtcaca tgcgactcat 3271801 ccaccacgat cataaaatcg tctgggaaat aatcaagaag cgtatacggc gttgaacctg 3271861 gaggccgcag agtcaaatgt cttgaatagt tctcgatgcc ggagcagaaa cccatttcac 3271921 gcatcatttc aagatcatat cttgtccgct gctctaaacg ctgcgcttca aggagctttc 3271981 cgttttcatg catgaccttc agctgctcct caagctcctt ctcgatattt tgaatcgcct 3272041 tctccatttt ctcggcccgc gttacgaagt gggatgccgg gaaaatcgca acatgatctc 3272101 ggtcgccgag aatttctcct gtcagcgcat ctacttcccg aatccgttcg atttcgtcac 3272161 cgaaaaattc aactctgaca caatgctcat cacgggatgc cggaaagatt tccactacat 3272221 ccccgcgcac acgaaatgta ccgcgctgaa agtcgatatc gttgcgggca tattggatgt 3272281 ctacaagttt tctgagcagc tcgttgcgct caatttccat ttcagtccgc agtgacacga 3272341 ccatttcccg gtattcctca ggcgaaccga ggccgtatat acaagacaca ctcgcaataa 3272401 taatgacatc tctgcgctca aacaaagctg atgtggcgga gtgtctcagt ttatcaattt 3272461 catcattaat actagcgtct ttctctataa atgtatccgt ttgaggcaca tacgcctccg 3272521 gctgataata atcatagtag ctgacaaaat actcgacagc attgttcgga aaaaattcct 3272581 tgaactcact gtaaagctgt ccagcaaggg ttttgttatg ggcaatcacg agagtcggct 3272641 tattgacttc tttaatcaaa ttggacaccg taaatgtttt cccagttcct gttgcaccca 3272701 gcagagtctg atgcttcttg ccctcctgaa ttcctttcac aagcttttca atggctttcg 3272761 gctgatctcc ctggggctga tatttcgaga ctaactcaaa gcgatctttc acaaaaataa 3272821 gcctccgttt ctttaacgaa atcttcctat agatatagta acacaatgga aagcaaaatc 3272881 actaaaaata cgaactaaag ttcggtggtt ttttatttcc agctgttttt gtgtataaaa 3272941 aacctgcttt taaaacgtaa aagcaggtat tcagtcttta tattcattat gtccgattta 3273001 ttcttctttt ttctctgcag cttttttggc catatacagt ccgccagcca caagagacac 3273061 aacatccaat cctacaataa aatacgtttc tgtatagcct tttaaataag aggcaaacag 3273121 caatgcagct gttaaagcga tcgccacata atgattaaag gtgactctag taaatagaac 3273181 aacaagcata aaagggaaaa acaatgcaaa aacggctttt gtaatcaaca aaaaccctcc 3273241 tcagggattc ttcatctgat ctgattatag taaaaaatga agaatcggac aatcgtgcat 3273301 tcgctccctc tacttacacc ataccccttt tcagccaaaa tcaatcacca tatttgcatt 3273361 ttggtgccgg tcaaaactta ttccatggtg ccgctgttct aatcagcggc acttttttta 3273421 ttacatcatc aagtccgccg ccagattccg agaataaaag aaaataggca tacagtacca 3273481 gtacggccgc atttttcagg ataatataac caacttaact attcatttta tttaggactt 3273541 tctgcgtttg acagcatttt cctgaaaacc tacaattaaa tgatagtgtt tactatcatt 3273601 ttttaaacac aggctccgca ataaaaagac tagagagaaa aacaaaatga atgaagaaaa 3273661 gaggggtttc aaatatgtat tctgttttat ttcgccaggc agaagagtcc agccagctgg 3273721 ctggagcaaa aggaatgaat ttgattaaat tgaccaaaca cggtcttcct gttccggacg 3273781 ggtttattat tcaaacgaat gcgctcgcac gttttatgga ggacaaccag cttcaagaga 3273841 ctagtgaaaa cgtcgaaggc gggatcattt ccggaacatt ttcggatgag ctgaaagatg 3273901 agctgactag ttccttttat aagcttagag aatcatatcg atccgtagcc gtgcgttctt 3273961 cgtctgcttc ggaagattta gaaggcgcct cattcgcggg tcaatatgaa acctacttaa 3274021 atatcaaaac agaggaagag tttctggcta aagtgaaaga atgctgggcc tcattttttt 3274081 ctgggcgggt cagcagctat aagaaaaaaa tgaacaatca aatcgcagag ccgttaatgg 3274141 gaatagtcgt tcaggggctg atcgattcag aaatgtcagg tgttatcttc agccgcaacc 3274201 ctgttaccca tgatgataga gagcttttaa tcagcgccag ctacgggttg ggtgaagctg 3274261 ttgtttcagg aaatgttacc ccagacacgt tcattgttaa taaatcttcg tttgagattc 3274321 agaaagaaat aggtgcaaag gaaatctaca tggagtctgc ggcagaagga attgctgaaa 3274381 aagaaacgag tgaagacatg cgcagccgtt tttgccttac agatgaacaa gtgattgaat 3274441 tggctgaaat cacaaaaaaa accgaagacc tgtacggata tcctgttgat atagaatttg 3274501 gaattgctga tcatcaaata taccttctgc aagctcgccc gattacaacc attgatcagg 3274561 acaaaaaagc ggcagaagaa aaacgcagct tcatgattac cgacactgat atgaatgatt 3274621 tctggcttaa catggagtct aatattgaag gtccggtgag tccgttattt tcatccttca 3274681 tcgtgccggc attggaatat ggcttgaaga agagcatgca aaagtttccg attggtgtag 3274741 ttgttgatga agtaaaactt tatcgcggac atatttattc caaaaaccaa ggcggacagc 3274801 agcctccttc tgaagactgc ggcaaagagc ttttcccgat tttatcggag catatgtatg 3274861 acatcatcaa tcacacatac ctcccttttt accggacact ggaccagctc gcacaaactg 3274921 agcataccgc agaaagcgca ctggaagctt ttcaaaaact aaaggccttt tatctcacgg 3274981 cttatgaaga gcactttaat atcgttttcc cgcaaatcct tttaacaaac aaactgcaag 3275041 cgatgtatca ggacattcaa ggagagtccg aaaacgctca tttttacgag atgctgacag 3275101 gaaaaatgaa caaatcactg gaaacggacc gttgcttatg gctattttct gtggaagttc 3275161 aggagaaccc gaaccttctg gccatttttg aaaacaacaa gcctgaacag ctccaggaga 3275221 aattggaaca aacagatgag ggaagacact tcctgaagaa cgtccatgaa ttcttgcaag 3275281 aatacggatg gagatctgtt aaaagtcatg atctgattga acaaatctgg gtggaaaatc 3275341 cgtatttcgc tctggccaat attcaaaatt atgtccgtaa tggctatcat tttgacaatg 3275401 aatttcagaa aacaaaagaa aaacgagaga aattatacaa tgaattcttg gaaagcatag 3275461 aagatcccgg tttacgcacc gaatttgacc gctattatca atggacactg aactctgcaa 3275521 atataaaaga tgatcaccac ttttatattg acgccatgct ggatgccaag gcgagaatct 3275581 ttctgctgaa gataggtgaa ttgctggcgg aaaacggtgt cattcaagat cgggaggacc 3275641 tttggttctt atatgacgac gaagtggaac aagcgcttct tcaccctgta tccctgcaag 3275701 aaaaggctga aaaacgcaga cagatttttc atgagtatga gctggcccaa gccccggcct 3275761 acctcggcac cccgacaaaa gaacagctca aagcagctga agaaattgtc ggcgctgtga 3275821 tagaggatga aaaaaacaca gagaatcata tttttggcat tgcggcatca agcggcattg 3275881 cgacaggtcc ggtgaaaatc attcgggacg ccaatgaatt ttctcaattc gcgcctggag 3275941 acgtactcgt ttgcaagatg accacaccgc tatggaccag cctgtttcaa gacgccaaag 3276001 cgattattac agacacaggc ggcattttgt ctcacgctgc gattattgcc cgtgaatacg 3276061 gcattccagc cgttctcggc acacgcacgg caaccgaaag actgcgagac ggtgacatca 3276121 tcactgttga cggaagcagc ggcaaaatca cagttgtcag ccggtcctga tgcgtccccc 3276181 tctttcttat acaagcgggg cgggtgtata cttgtcctgc cagtatattc gtgaggtgaa 3276241 acgtattgag accgacaaac aagagaatcc ttgatgctgc catgcagctg ctcgtcaaaa 3276301 aaggatatcg cgcaacgact acaaaagaaa ttgcagaaaa agcaaatgta agtgaagcga 3276361 cgattttcag gaactttaaa aacaaacaag gactagttga ggctttgctt tctcagcatt 3276421 cttcaaacag aggcagcatt ttggaacaaa cagaagggga tttgtacaaa gacctgcttc 3276481 atatcggaac ctgtctcttg gaggagctcg aacatagaaa agatatcatt aaaatcagct 3276541 ttcgtgaacc ggccatgttt caggatgtca ttaaccacgt cactgaatat ccccaatcta 3276601 tgaaacagct attggttgat tatctcaaaa cgatgggtga gaaaggggtt attcagacag 3276661 gaaatgaagc ggaacatgcc gacgtgttca tgtcgattat cttcggttat ttcattcacc 3276721 gtctccactt aggagaccgg gtcatatcaa tgccccagga aaaaatgctg gagcatagca 3276781 cagctctatt tgtcaaagga atttctgctg attaactcct tggcataata aaaaggagga 3276841 tcccaatgag ctcaagaaaa gaatgggcgc tgatcgtctc gctattattg ggggccattc 3276901 tggttcccat taactcaacg atgatcgcgg tcgcgctctc atctatttcc catacgtata 3276961 acgagtccat cgcaagcatc acttgggtgg ttaccgttta tttaatcgtg atggcagtca 3277021 cacagccgat tgcaggaaag ctcggtgaca tgtacggcaa taaaacaatg tacttatggg 3277081 gagtcggcct ttttctaatc gcatctctag gctgcgccct ttcaccgagt ctgctcctgt 3277141 taattgtctt tcgggcattg caggctgtcg gcggggcatt gcttacgcca aacagcattg 3277201 ccattatccg gcatgttgtt tctgaaaaac gcctaccgaa agtgtttgga tttttcggac 3277261 tgggcgcggg acttggtgca gcactcgggc cttttatcgg ctctatactg attgacagct 3277321 tcagctggca ttcgattttt tgggtcaaca tcccgttcct cgccattgct ttatttacgg 3277381 cattaacgat gtttcctcaa tataaagaaa ataaatctga cgcgccgctg gatatcatcg 3277441 gctctctctt gcttgcaggc agcatcgttt ccattatcct gctgacgaaa aatgaggctc 3277501 catggggata tactgtatac agtgtattga tacttctttt tgttccgctt tttttcagaa 3277561 gagaaaaacg tacccagcac cccatcattg actttgcact gtttaaaagc tcaaccttta 3277621 caaatgcgaa tctatcagtc ttgttaagca atttgatgat gtatgccgtc ttattgatta 3277681 tgccgttatt tatgacgaac caatttgggc ttaatacatc taacagcggg atggcgcttt 3277741 ctgtattttc gatcttcatg tcagccagca actgggtggg cgcgcagctc catcacaaat 3277801 ggggagccaa aaaaatcatt tttctttcat ttgccatgat ggctggtgcg aatctattat 3277861 ttttgctgtt aagcagctcg cattctgtct tgttcctcat gctctctctt atccttggcg 3277921 ggctcgcttc cggagtcggt ctgaccagca tgcaggtttc atcccttgcc acagtagacc 3277981 ccggtatgtc aggagtggca tctgggattt tctcgacctt ccgttatttc ggaagcatca 3278041 tttcatcagc cttaattggc ctgatttcgg gatatcacac cctatttatg attctctttg 3278101 ctgtatccat catcggcgtt tttgtttcat tgggcatcaa atctgatgaa acggcacgga 3278161 tagaaaaaaa ctcagcgtaa cacaaaacag cccggcatcg catcatcctg cggtgccggg 3278221 ctgcctttta tgatcccgaa gcgactgctt cgtcttcacg gtcatccttt acgaagagga 3278281 tgcccaattc atgatgttct ccttcataag aagctcgctg gtcaaaacga atttctccat 3278341 tcaaaccgat aatttcaagc tttacatatg cacggttatg ctgaagcgct tcatagaaat 3278401 cagaaacgtt cttaaccggt atgccattga ctttcgttat gatttccccg attttcaatt 3278461 ccagatcctc agccggcgta ttggggataa tcccaagcac cattaagccc tgatcccttt 3278521 tcgagaaata aaacggagcc gcgttatcat tcactctttg ctttatggac agaaaaatac 3278581 gccctaacaa agcggtacag accgctgcac ccgcaagcgg cgtccacagt aagctcgctg 3278641 caccgagaac tgcgacggca agaccgagaa tacaaacgcg tttcgctgtg atccttatac 3278701 tcgtttcagg cagcgatccc tgtacccttt gtccaaatcc gacaaagtaa ggaatccata 3278761 gaaaatggaa tgagccgccg ggaaccgtaa acacgggcca ccagctaagg tgcgattcta 3278821 aaccattacc gggcacgaga aggaacagcg gcaaaagcca aacccggttt gccagctgct 3278881 gtccgatcgg caaaccgcgg ctgcttacga caagtgccgg tgatgttctc acatgcgcag 3278941 aacgataagc aaccgctcct tcagtgataa tcagcaaacc tagaaacaca gccacagccg 3279001 gccaaacaac tgcaaatcct tgcggaaatc tctccagaaa gggctccgcc tgatatattt 3279061 gcagtccaaa acctatcagc atactcacac tgacgatata tgcagcagac atccagtttg 3279121 cgcgaagagt gaacgctgcc gctgcagtga taacggcaat aatcgcaagt aaaccgagag 3279181 gaatcgatat tccgagtcca cctaaaataa ctgacaaaag aagacctgga atcagtccct 3279241 ttgtatatgt aaatttcaga tcatcataaa tatctgctat tcttgtatga aaggtttttc 3279301 gttcccgttt gattcttaca tagccgaaag ccaaggttat gatgataaaa aaccagaaaa 3279361 gcgggtgtaa gaagaacaag cccgcgcttt ttaacagttc aattccccat tgaacagaca 3279421 ctatctctca ccgcctcaag ccaaacatgt tactcatatt ctatcaaata ttaaatggct 3279481 tggatatcct caggagagtt tatctctctt gcgtcatcca cagcgtgaca ttcgatagtg 3279541 aaaaatcctt taaatagtgg tttacatcca catccaataa cccgctgatt agatgcatcg 3279601 acctttttat atctgtcaga ttaattccta atcgcttatg gtttttcatt aagtagttaa 3279661 aataatgttt ggcgcattcc tcattaatgt catttactga ttcgacattg gtgtaattga 3279721 ccaaatatct gctgaacagc ataagaagac ttagtgcttt tgtagctgaa aatgttacgt 3279781 cttgtgttct gtcttttaat tgttccacta attcataata tttttttttc acgcacaata 3279841 cttgccctct tcaattgtga acccccattt tctttataca gataagcacg ggccagtata 3279901 agcagcagta ctggagtgct aacaagcatt ctcgctaacg ttactcttta aatacctgtc 3279961 gttcagctgc cattaacctg attactgttc tttttagaac cttcttatat tgtatgaagt 3280021 aaacaaagac taggcaactt gcaaaagttt cattttaaat gcatattaac tcgttagaaa 3280081 gtctctctca tatattgata tcgggtaata acagtccttt ataaatgttt atttgtgaaa 3280141 atttttttaa tttcttgtca aaaactcatt ttttatgtga cttatgatcc ataatctctt 3280201 taagcacaaa gaaacaggag atgaaatacc atctccttta attgacaaat aatgatttca 3280261 atgctgtttg aagctgcaaa tcattttttt catctgattt tttcttttct atctgctgat 3280321 ttaatgtctc tgcagtgcga gtgtcgatca caccggtttt attcagcttg ttttgatcct 3280381 gaaaagccat aaccgctttt ttcatgtctt tgctgaaata gccatcctca cgtcccggat 3280441 caaagctgag accttttaac aatacctgcg catgcttgac gtcttcattg ttcatgtcca 3280501 ctttaagcgg ctctttcagc tgtaagggcc cggcggaaaa ataatcgggc tgcttaatcg 3280561 caatggtcgg ttcaattcct ttcttatgaa tccagtttcc atttggcgtc agccacttgt 3280621 aaagcgttaa tttgatgttg ctgccgtccc ccattggcac agcctgttga accgttccct 3280681 ttccaaaaga cgtatcgcct acaacatcat aatggccagc ttcctttaat gcgccggcaa 3280741 gaatttctga tgcagaggca cttcctttat ccgtaatcac attgacaggg tacgcttttt 3280801 tatgggtcaa tgttgaaaaa taacgttttt tatctccatt gcgttcagca atctgaatat 3280861 acggctgatc ctttgtaacg aaatgcttaa gaatttcttc cacactttga agatatccac 3280921 ccgggttgcc gcgtacatca atgacaagtc cttctatttc ttttttctca agctccctca 3280981 gcgcttttgc aaaatcctct gcggtgtgct cagaaaaagt agagatggca atatatccga 3281041 cagaatgccc ctgtactttt ttctctgatg caaaaaccgt ttcgagcgga atctcagctc 3281101 tcttgatccg gaatgacaac tgcttcttcg ttccaggccg ctgaatcttc attgaaacgc 3281161 tggacccttt ttttcctctt atttttaaca cagcgtggtt taaatccttg ccggccatcg 3281221 attctccatt gatgctgata atttcatcat taggcttcaa cccggctttt tccgctggcg 3281281 atttcttgaa tggagaaaca ataataattt tgccgtcttc cattccaacc tcagccccga 3281341 tgccttcaaa tgaggaatca agagaatcag aaaattgctt agctgtctgc ttgtccatgt 3281401 aaacagaata aggatcattt agcgtagaca gcattccctg gatggctccc tcgagcagct 3281461 tttctctatc tactttttct acgtactcat tcgaaattaa ctcatacgct ttttcgattt 3281521 tgtccatagc tttatcccgt tcagagtcag cttgtgccgt cgcgggaact gctgcagtct 3281581 ggggcttatc catctcaagc aggttgattc ccgcatatac accggcgcct ccgaacagca 3281641 tgctccctgc tgctatcaca gccattattt tttgattcat cctttactcc tcctgtatgc 3281701 cagactgtct ttaccaaaac ctagagatag tatatgtaaa ggatggagat ttcatgtaat 3281761 catagaagaa aaagaaggca aatgaaaagc cgtcccgaaa acggaacggc tttttcactt 3281821 tatactcgca gaaacttgcg gatggaagtc agacttcccc atactccaat tactgcgccg 3281881 attgcaatca gcactagcga aacttggaat acaaatggat tataaggaag aagagagaca 3281941 aatgatcctt gaacctttgg aacgacccat ccgatgacgt attggtaagt gctcagcacc 3282001 agtgcaatcg gaatcacaga accgaatacg cctagcagca atccttcaag gaaaaacggc 3282061 cagcggataa accagtttgt cgcgccgaca agcttcatga tttcaatttc ttttcttctt 3282121 gcgaaaattg taattttaat ggtgttggaa attaagaaca tcgccgtaaa taccaggccg 3282181 ataattaacg cgattccgat gttgcgggaa acgccgacca ctttaaacaa acggctgacc 3282241 tcttcttttc cataagtgac tttataaaca tgatccattt tttcgatctt tttcgccacg 3282301 ttcggcgtat catgcggatc tgtcgttttg acgacaaacg catcattaag cgggttttcc 3282361 tgatccttca ttgtcaggga ttttccgctg tcaccaaaac tgtcaaccag ctggtcaagc 3282421 tctttttctt tagatgaaaa agtgacactc tgaatgccct tcagttcctt aatatcgttc 3282481 tgaagcttgt cctgtgcctt ctgatctgca gtcagatcaa tcagcacttt gatttcgact 3282541 tgtttttctg cattcgtggc catgttattc aaattcagca taatcactaa aaacacgccg 3282601 actaaaatca gcgtaacggt tacagcacta atggatgcaa atgtcatcca tgtgtttctc 3282661 ccgagagatt taaaactctc acgcaagtgg cgcccgagaa ttttaatcat atgaaccata 3282721 ctcccctctt gactcatcac gcacaatgat accatcttcg attgcaatga cacgtttctt 3282781 catggtgttt acgatttctt tattatgtgt cgccatcacg actgttgtcc cgcggttgtt 3282841 aatttcctcc agcgtcttca tgacttccca ggacgtatcc ggatcaaggt ttcctgtcgg 3282901 ttcatcagca atgacaacat cagggttgtt cacaattgat ctggcaatag atacacgctg 3282961 ctgctccccg cctgaaagct ggtcaggaaa ttgtcgcgct ttatgcttca gctgcacgag 3283021 atcaagcact tcaagcaccc gtttcttaat gacagacggc tgttctccaa tcacttcaag 3283081 ggcaaatgcc acattttcaa aaacagtaag tttcggaaga agcttgaaat cctgaaagac 3283141 aacacctatt ttgcggcgca cgaaaggaat ctctttttct ttaattgtcg cgagatcttt 3283201 atgattgatt aaaatttgtc cttttgtcgg tttttcttct ctgtaaatca ttttaataaa 3283261 agtagattta cctgctccgc tcggaccaac aacatacaca aactcgccgg gatgaatggt 3283321 aacagaaatc ccattgagtg cttttacgcc gttcggatag gctttatata cttccttcat 3283381 ctctatcatg aaatcaccta atcttttata tcattttatc tatcacacgg tcatactctt 3283441 cgaatgcatt cgacaattta tgacccattc atttgtaaaa agatgaaaaa tctgaaagtt 3283501 ccctttttca atacacttca ttatacgtca aatttagaca taatactatt acagtttctt 3283561 ttcattcata ttgtcaaggc ataaaaacat ccttgccagc actcggcaag gatgttttta 3283621 tcttactttt tttctgacag ccatttggca ataacagcgg cttcgttatc atctacaagc 3283681 ccctttggca tattgccgcg gccgttttta ataatgcttt caattttgtg ttcatcgtat 3283741 ttgcctccga cctcttggag attaggccct gacacacctt ctaaatcctt gccgtggcag 3283801 cctacgcagc tttgctgata taattcttcc ccttcagatg cagtggcttc cgtcttgctg 3283861 ccagtgtctg tcttctcttc ttttgcatcg tttgatccgc aggcagccaa cagaacagaa 3283921 agcgcaaatc caatcattag tatcgataac tttgatttca tgttgagaag cacaactcct 3283981 ttacgatctc ttccatatta taacctcgtt taagcgcgtt tgaaaccctc gcccagcacc 3284041 tcgctcgcgt ctgctacaat tacaaaagct gactcatcaa tctgtttgac gatttgtttc 3284101 aatttggtga attcagtttg cccaaccacg cacattaaaa tcggacggtc atcgtcagta 3284161 tatccgccga ctgcagaaat ttttgtcacg cctctgtcaa tcttctgtaa gacagcctcc 3284221 ttgacagcct gctcctgctt tgtaatgatg agcgccattt ttgaacgatt aaagccgact 3284281 tgcacaacat caatggtttt gctggacaca tagacgccaa gcatggcata taagccttgc 3284341 tcaatattaa atacaatcat agccgtaaca acgatcattc cgtcaatgat ggcgagacac 3284401 ttccccaatg acagaccgga gtacttatga atgatctgtg cagccaaggc tgtacctccc 3284461 gtcgaacctt tccctaagta cacaatacca attccgatac ctatcccgac accgccaaaa 3284521 atcgccgcca ggagttcatg atgagtggcg ggctgaatat cccttgtcag aaacactact 3284581 agcggcaaaa acacagaacc tgcaagcgtc tttagtccaa atttcccgcc gagcaaaatg 3284641 acgccagcaa taaataaagg gatattaata atccactgta catacgctgc ttcaaaacca 3284701 tatgattgta aaatcgtact gatcccgctg accccgccgg cggcaatctt attcggaagc 3284761 aaaaatacat taaaggacac ggccgtaatc gctgctccta tcaatatgta tacataatcc 3284821 cgcaaaatcc acaatgtttt attccgtacg tccatcatat atcctccgtt tcttccaatg 3284881 ctctccgata gcattttaat ccttccctga ttagatgtaa ataacaccca aatacagtgg 3284941 taatatgcta aagcagcagt gaaatcaagg atataagaaa taaaaaaaca cacccgtatg 3285001 catcaggtgt gtttttcagc ttatgaaagc ttagaacgca ggtaggcatc aataaacgta 3285061 tcaatgtcac catccattac agcttgaacg ttccccattt ctgtattggt ccgatggtct 3285121 tttaccatgg aatacggatg gaatacataa gaacggattt ggctgcccca gccgatttct 3285181 ttttgttcac cgcgaatttc atccagctct gcctgctgct cttcaattct gcgctgatac 3285241 agcttggcct tcagcatttt catggctctt tcacggtttt taatttgtga gcgctccgtt 3285301 tggcatgtca caactacgtt cgtcggcaag tgagtaatcc gaacggctga atccgtcgta 3285361 ttgacgtgct gtccgcccgc gccgcttgca cggtacgtgt caactttaat atcctccgta 3285421 cgaatatcaa tatcaatttc atcgttaaat tcaggcatga cttcacatga aacgaaagat 3285481 gtgtggcggc ggcctgatga atcaaatggt gagatccgca caagacgatg aacacctttt 3285541 tctgctttga gatacccgta agcgttgtgt cctttgatga gcaatgtcac tgacttgatt 3285601 cccgcctcgt cacctggaag gtaatcgaga gtctctactt taaagccgcg gcgctctccc 3285661 catcttgtat acattctaag aagcatagag ccccagtcct gtgactctgt accgccagca 3285721 ccagggtgca gttctaaaat cgcgttattt ttatcatacg gctcgctgag aagaagctga 3285781 agctcaaact cattgaactc ttttgttaat gactttagtt ctttttcaag ctcaagctgg 3285841 agatcagtgt ccggctcttc tttcaaaaga tcatgagtca tttgtaattc ttcgtgggat 3285901 tcattcaatt ttttatacga attgacataa tcctttaaac cgtttgcttc atttataacc 3285961 gtttgagctt tttgctgatc attccagaat tccggatcag ccatttgttc atctagctca 3286021 gcaatgcggg cctcctttga ttcgaggtca aagagacccc ctaaagtccg ctaaacgaga 3286081 agccatattt tcgagctctg ctctaatttc tgataattcc atttcattca cctcattaaa 3286141 agatccgcag gcgcctgcag gcgccgcggt cagtaaactt gccggggcga actattcagt 3286201 acggccgcag caatttttat attttttccc gcttccgcag tggcatgggg catttcgtcc 3286261 gatatcaacc actttgcgaa ccggtgcttt ctttgctttt ttgttatcgt cgccttcttg 3286321 cggctgatga gctgttgttt gaccttgtac aacctcttca cgctccagat tgttttcaat 3286381 ctcagctttc atcacaaatt ttgcgacttc gtcctcaatt gattcaatca tatgctcaaa 3286441 catcgcaaaa ccttccattt gatactcacg aagcgggttc gtctgcgcgt aagcacgaag 3286501 gtgaatccct tggcggagct gatccatcgc atcaatatga tccatccatt tagaatcaac 3286561 ggcacgaaga acgataactt tttcgaattc gcgcatttgc tctttgccga attgctcttc 3286621 cttctcatta tattttgtga tgatgcgatc cataatgagc tcaagcattt catccggttc 3286681 tttgccgaag atatcgctct tctcaagtgc accttcatca agataagttg tgttgataag 3286741 atcaactaga ccgtcaagct tccactcctc aggaagctct tctcttggcg tataggctgc 3286801 aattgcgcgt tcgagagaag acttgatcat attttcaacg atttcacgca ggttttcaga 3286861 gtcaatgact tcaaagcgct gcttataaat gacctcacgc tgctggcgga gaacatcatc 3286921 atattgcaga agctgtttac gcgaatcgaa gttattgcct tcgacgcgtt tttgagacga 3286981 ttcaaccgcg cgagatacca ttttgctttg gattggagta gagtcgtcca tgccgaagcg 3287041 gtcaagcatc gccattgtcc gctcagctcc gaatctgcgc atcaattcat cttccataga 3287101 aagataaaat tgagtaatcc ccgggtctcc ctgacgtccg gaacgacctc gaagctgatt 3287161 gtcaatccgg cgtgattcat gtcgttctgt tccgactaca gcgagcccgc caagctcttt 3287221 tacaccttcg ccaagcttaa tgtccgttcc gcgccccgcc atgttagtcg caatcgtaac 3287281 tgcgcctttt tggccggcct cttcaatgat ctgcgcttca cgttcatggt ttttggcatt 3287341 taacacttga tgcggaattc ctttgttttt aagcagctta gaaatcaatt cagatgtttc 3287401 aacggcaacc gtaccgacta gaacaggctg tcccgtcatg taacgctgtg cgacatcctc 3287461 cgcaactgcc ttaaactttc cttccatcgt gcggtaaatt aaatccgggc ggtcatcacg 3287521 gacaacaggc ctgttggtag ggatcgtgac aacctgcatg ttgtagatgt tgcggaattc 3287581 ttcttcctct gtcttagctg tacccgtcat accggcaagt ttttcgtaca ttcggaagta 3287641 gttttggaac gtaatcgtcg ccaaggtcat gctttcgttt tgaatctcaa gcccttcctt 3287701 tgcttcaatc gcttggtgaa gcccctcact gtagcggcgg cctttcatca gacgtcccgt 3287761 gaaggaatca acaataacaa cctgtccgtc ttccactaca tagtcaacgt ccttttgcat 3287821 cgcaacgtga gcttttaagg cctggttgat atggtggttg agcgcgacat gcttcacatc 3287881 aaagaggtta tcgatgccga atgctttttc cgccttcgtc attccttctt cagtaagctg 3287941 tacagctttt gttttgatat cgtacgtgta atccttctcc gcttttaacg tgcggacaaa 3288001 agcatttgcc tgtacgtaca gcttagtgga ttttgcagct tgtccagaaa tgataagcgg 3288061 tgttcttgct tcatcaatta aaatagagtc aacttcatct attaccgcaa aatgaagcgg 3288121 gcgctgaacc atctgctctt tataaagaac catattgtca cgcaaatagt cgaagccaag 3288181 ctcgttgttt gtggagtaag taatatcagc ggcataagct tcccgttttt cgtcttttga 3288241 cattgagttt aaattcaaac cgacagtcaa accgagaaac tcgaaaattt tccccatttg 3288301 ctcagcgtca cggcttgcca agtattcgtt gacagtcacg acgtgtacgc ctttaccggt 3288361 taacgcattt aaataaacag gcagggtaga cgttaatgtt ttcccttccc ctgttttcat 3288421 ttccgctata tttccgtcat gaagcgccac gccccccatg agctggactt taaacggaaa 3288481 catgcctgtt acgcggcgtg aagcttctcg aacaacagcg aaagcttcaa caagaagatc 3288541 atccgttgtc gccccttttt caagacgctc tttaaattca attgttttat gtttcaatgc 3288601 gtcgtcagag agattttcat agtctccgcg aatcgcatca atatcgttag caattttttc 3288661 gtatctattc agcgtacgtt ttgttggatc aaacatttta tttaaaattc caagcattta 3288721 taacgctcct ctatcatcac acgcctattt tagaggcatg tataaataat ttactagtcc 3288781 atgtatacct ctcattatca tatcatacct tttgttattt ccaaagaatt tgcaaataag 3288841 aaaaacaaaa accttccgcg gacatcacgg aaggcttctc ttcattattc agtcggttca 3288901 attaagccat atttcccgtc atttctgcgg tacacgacat ttgtaaggtt tgtttccgca 3288961 tttgtgaaaa caaagaaatt atggccgagc atattcattt gcaagatcgc ttcttcacta 3289021 tccatcggct ttaaattaaa gcgtttctga cggacgatgt ccaagctctc ctcctcttct 3289081 atgtcatcct gaaccgcaat atctgtatca gagccaagac cgtttgccaa taaatatttt 3289141 ggagagccct gctcacggaa tttacggttt actttcgttt tatgcttacg gatttgacgt 3289201 tccagtttgt ttgttgcgag atcaattgcg ttgtacatat cctcgttatg cacctcggac 3289261 cgaagcgcca gatctgtcat cggaatcgta acctcaacct tagactcctt gtcattgtaa 3289321 aacttcaagt tgacgttcac atcagcatcc acgctatggt caaaatagcg ctccagcttg 3289381 ccgatcttcc tctcgacatg atcctttaac gcgggtgtca cttcaatatt ttctcctctg 3289441 atgttatagt tcatcaaaga acgcctccct tttattaagg atatgtatct atttctcttt 3289501 taccctttac aattcctgct gaaacataaa tcttttgtga aaattcagtg aactttgtcg 3289561 aattttgttt gtatttgctc tgttattggc ggttcggagg tatatgtata tgctgattga 3289621 acgaaacaaa tacctcacac acgcctaatt gattaaaaag ggttccatac attgatgaat 3289681 agacagcatc cattttctat aatgaatcag aaaatgttcc tttaaatact cacagaactc 3289741 atgagaggga aaagagaaag agaccaattg atcaaactcc gcaaaaattt ggtcaaatgc 3289801 tttcacacaa atttcagcac accgcgaatc cataatgaag agaagtgttg aatgtgttga 3289861 atccaaataa aaaaaggctt ggatcagatc ttggtagatc cgatcccctt ctgtttttga 3289921 taaattctct tcagcctcta tcaaataaca caacccctct tcgatggtaa aaagaagatg 3289981 ataataagct gataaaagcg tataatcttc aatgctcttc aaggcactca cctatttacg 3290041 cttgtcataa tatgtgccgt caatcgtaat gttgttataa gggtttaaat acgtcgtatg 3290101 catcacacgt tttcttttca tctgctgaag ttctgttgcg attgactgct tcagtctttc 3290161 catttccttc acaatcagct gatcccatgt caaaataagt ttcatctgct ttcgctcttc 3290221 ttctgaaagc ggcagagata tctcctgaat cagttcagac cgtgtagcca caaagtcttc 3290281 aatttgcttt aaaagttcat cgctttccgg cgtattttgt atgtgtgaca gcatactctt 3290341 cgtctcagtg tatagttgat ctatattatt catgcgatcc cgcctgatcc gtgccggtcc 3290401 ttccgctcac tttgaatggc ttgtttccaa gcatcgcgaa aatctgttac ataaccttca 3290461 acctcagcca gcatgcccgt atcatttttg atatttgcct gtaccaatct gcgatacata 3290521 taatcgtaca tcgcacccat agaagcggaa agctctatgt tacggttaag tgtaaaattt 3290581 aattcctgaa taatattttg cgctttaatc agattttcat ttttacgttc catatcatca 3290641 ttctcaatgg cctgagcggc aagtcttata aatttcaaac agccattata cagcataagc 3290701 gtcagctccc cgggtgtagc cgtattcact gaattttgct gataggctgt atatggattt 3290761 tggatcgcca tgtgtcatcc tccaaattac atttattgta caagaagctg tgataaatag 3290821 gacgcttgtt cgttcatttt ttgaatcgca gaatccattg cactgaattt tgaataatag 3290881 cggttttcta tggtattcaa tctgtcctgc atatcagtta tttcagtact tatcgagttt 3290941 aaattttttc caatggaata gctactagct cccattgtcg agttcccagc tttagcttca 3291001 atacttttca cagtacttct aagtgtatta gtaatccgct tcataatacc tttatcgcta 3291061 tagttactat catttgttcc acttgtaaaa agattagcaa ctccttgagg atcttctgct 3291121 atttttgctt tcaatttctc ttcgttaatc tctaagtgcc ctcgcagttg gtaagcactt 3291181 gaagttgtga tgccaaattc agttaattga taggttttcc catccgcatt cacttgagta 3291241 taaaagtcag tccgcatttg gttcgtgcca gtgctgatgc ttgaatcgtt tctcagcaat 3291301 ccgcttttcg ccttctcctc ccagagctct acctctttat cggacatggc ttctttttgt 3291361 tcactcgtga gtggcgtata gtctcggtat ttttcttctt tcagcttttc attcaggctg 3291421 tcaaccagtt cattgtattt atctacaaac tctttgattt ggttataaat cccatcaaca 3291481 tcagtagaaa cagatgtggt aacagggcct gtggctgcag ttgtattttt aatcgaataa 3291541 gtaacaccat tcaccgtgaa attgtttgtc agcttctcca tttcaaagcc gttgattgtg 3291601 actttggcat ttgtgccttc tttgtaagca gtaagcttat tatcagcatc caaagaaaaa 3291661 ccaagctgac cggacataaa gtcagctgta gcagagtctg ctgcctgtat gcttcctcct 3291721 gcacctgttg ctttagaaga aaacgcaatc gtttctacgt actctgtacc attccaaatt 3291781 ttatctttaa atgctgatac tcctagatct gagctgttaa gtttagaaat cacattatca 3291841 atcgtatcgg cactcgtcac actaatgttc actgtttttg ctgttgtttc gccaggcgca 3291901 acaacgttaa atgccaaatt gtaatcgcct tgtgtgtatc ccgtataatt gtttgcctta 3291961 tacgttgctg cagttgccaa gctcgccact tcaacagtag acgaagaatt tggcgcactt 3292021 acgcttcctg tagcagttaa cacagactca ttagagcttg tcacagtttt gctctgatac 3292081 gtgctcggat atgtcaacgt atttttagac atataatctt gcaattcttt tatttttgag 3292141 tttacttcac gatagctgtc acgctgccat tcaagagtct gctttttttg tgtcagctta 3292201 tcaagcggcg ctctttctgt ctgcatcagc tttgatacga tatcatctat atccattcct 3292261 gacgccagac ctgttattct tgtgaccatc tcaaaccact cctattctac tttttttcat 3292321 ctacaaataa cccaagaaat tcagtcatag ccgcataaaa atcaagccac cgttttggtg 3292381 gaatttcgcg gatcacttca tttgtagagt cctctattac ctttacatag tattcattta 3292441 acttgtcatg aagctcgaac ttcagatgaa cttgcgaagg ttccaaaagc ttgttcattt 3292501 cccccaccat ttcagcaaga ttggtatatg aaacttgatg aacaggaacc tcgttatcat 3292561 tatctttctg attatgtatt tgagtatcat aacgatccca aacaggttgt aacgtagtga 3292621 gcctttcaat gttcaattga tcatccccta tgccccaatc tatcgtttat atcgactaag 3292681 tcgagataag attacacata tttttggaaa aaaatcttct gttttagatt tcttgtatgg 3292741 aaatacattt ataaaaagtt agtggagaat ccggttatta tatcatgagt tagtgacagg 3292801 atgaggaatg attaggagat agaaatttaa attaaaagac cctggcaacg ccaaggtctt 3292861 ttttaaaatt aacgtaataa ttgaagtacg ttttgcggct gttggtttgc ttgagcaagc 3292921 atagcttgag aagcctgaga aagaatgttg ttctttgtga attcgctcat ctctttagcc 3292981 atgtcaacgt cacggatacg agactcagca gctgtcaagt tttcaccaga agcgcttaag 3293041 ttgttaattg tgtgctctag acgattttgt accgcaccaa gcttagcacg ttgagaagaa 3293101 acttggttga tcgcttcatc aacaactttc aattgagcat cgaaaccgat atcagcagta 3293161 tctgctgcat tatctgcgaa ttttgttacg tcaagatcat taactgaatg aagagctgca 3293221 attgaaccat cagcttcttt aattccaaga gcgtcagcac ccatatcctc aatatttaca 3293281 gagatttgct gtgtagcatt tgctccgatt tggaatacca agttcttttg atttgcagga 3293341 gtagctgtgt caactttgta agtgccatcg agcaatttct taccattgaa ttctgtacga 3293401 tttgaaatac catcgatttc atctgttaaa gctgaaattt catcttgaat agattgcaaa 3293461 tcagttgctt tgtcctgagt tccagtgttt ccagcttgaa caactagctc acgaacacgt 3293521 tgaaggatcg catgagtttc agttaatgca ccctcagctg tttggataag agagattccg 3293581 tcttgagagt ttttagaagc catttcaaga cctctgattt gtcctctcat tttttcagag 3293641 atcgcaagac ctgctgcgtc atctcccgca cggttgatgc gaagacctga agaaagtttc 3293701 tccatgttct tttggctcgc actgttgttt gaagacaaac ggttcagtgt gttaagcgct 3293761 gcaatattgt ggttaattct cattgttttg ttcctccctg aatatgttgt taaggcacgt 3293821 ccttgtgccc ttattttgta actggctgag tcttttgcgc ctcctcccgg ctacatcatt 3293881 aatatcggat tgtctctgat tttgttaata caaaaataaa aaaatcctca ctttttttgt 3293941 gaggataatg cggagatcac atcgctggat aacgctgctg cacggttatt ttcttcctga 3294001 atggtcaagt aaatttcttt cctgtgaata tcaatatgct ttggggcgtc aattccaagc 3294061 ttcacttgat ccccttcaac cgcaatcact tttacttcaa tatcagcacc tatttgaatc 3294121 gcttcgttta ttttccgcga taaaactagc atgattctcc tccaatcgga tgctttgtcg 3294181 tatatgagga gtcgtgtaaa acgacttgct tagccatcat gttcttgcga ttcacaataa 3294241 tgggagccaa taaattcgca gtagactttt caaatggctc tgccatagtc aatattgtca 3294301 tgacttctac gtcttgaata ttatcgatat ccaaaagttc agcagttgat tcatcaagat 3294361 caaattcata attcttaaaa aagataaacg gacttacgac gataaacgca agattttctg 3294421 aagtgacgga ctgcagtgcc acgaatggag agtcttctga aagcggaagt atgacgaact 3294481 gtttttcttc taaaaagcct ggaatcccgc tttcaaaaag aatgatttgt tcttctttta 3294541 tgttcatttg gccatggtac ttcgtatgaa tgatcattgt tcacgatcct tttcttttta 3294601 cttttcgggt gattctttcg ggtattctac atctatattt aaatcagggt attgaagcat 3294661 gtcaacctta acatttcctg gcgtatattc aacaattggc ttatgcggct cagcctgaat 3294721 aacaggcttt cgcggcgtaa tctgcacatc aagctgtgac ggagtatatt gtattttcac 3294781 cctcgaaaga gaaggagcat aattttcgcc taattgaatt tggtgcattt cagagttcct 3294841 ccttgcttgt gaagcgattg ggttcccctt attttcaatc ttcataagct cgtcgccttc 3294901 ttctgcagtg cgtgctattc cctccattac atcctcatgc ccttgttggg cggcttcttc 3294961 aattctcttg aaaacatgct ttctgtctaa ttcttcccat gcttgtgtct ggtcaatcgt 3295021 gagttttcca ggtgtcaccg atatttccat ttccgcactc ggctgttcga tctctagatc 3295081 agcttgaggc tgctccattt ttaagctggc aggcgtcgtt gttaaaccaa tttttccttg 3295141 aacactatgc ataatcaatc tgggaatctg catcactcta cctcctgaac tataaaaaaa 3295201 gcgaactcct aagagccgct tactttaaaa agtcaatcaa tgtaggctga acaatttgcg 3295261 cattaacggc cagagtagcc ctgtgcacac tttgctgcgc aataaattca gttattactt 3295321 cttccagttc tacatcttca ttgtctgata acactttggt agctgtttct tcttgcgctg 3295381 acagtcttgt attaaccagt tcaagacgat tatatctcgc tccaagatca gatcgttcag 3295441 cgctcatgcc gtcagaaaaa tgatcaatat catttaaaac actgtccatg ccatctagcg 3295501 aaccagaatt tagtgctttc tcaaaagaat caagcatttc aaatacattc tgcccgcttt 3295561 cagaagtgcc tccaaaagct gactttggat ctgaattcac tttcaatgac atattatttg 3295621 atatattgac tacgacatca gctgtatcag aaattgtata agttccgtct ccgttatctg 3295681 taaccggagg cttatctgaa tttgtgccat taaagatata tctgccgttc acttgtgtat 3295741 tcgcaatatt taaaagctgt tcctttaact gctttacctc tacgccaatc gcttgccgct 3295801 ccggctcgcc gtttgtatca ttttgagctt caaccgctaa ttctctgacc tttgacaaga 3295861 tgtcaattcc ttctgtaatg tttgtttctg tgttttcgag ccaggtaaag gcttgagaag 3295921 cattgctttt gtactgctgc acttgagaca gttgcgtatt atactttaag cttttcattg 3295981 ctactacagg atcgtcggaa gcttttgaga ttttttttcc tgaagaaatc tgcgactgga 3296041 gtttatccag cttcgagtag cttgaaccga tatatctcag tgagttttgc tgtatcatgc 3296101 cttgtgttac tctcatgtga ctctacctac cttcctccaa cacccatgcc gttgatcact 3296161 ttatcaagca attcgtcttg taaagtcacc attcttgcag ctgcattgta tgcgtgttgg 3296221 aattgaatca tattcgtcat ttcttcgtct aaagaaactg cgctcatttg ctgacggttt 3296281 atgtcagcat cattcagctg tgtttctgta ttagacgcca gtcgattagc ctcttgagct 3296341 tcgatcccta gctcgccaat cagacccgca taataatcta aaacactagt ttctttaccg 3296401 ttaatggtta ttttaccggt taaaacattt gctaattttg tagcatttgc gttatcgttg 3296461 gctgcgccag tcagtgagaa agcaatgttt gcgccttttg aatctattat gctgtcagcc 3296521 actttgatct tgcccgccgc gcccttggca ggttcagttt caccgccagt aaaatcaaaa 3296581 aagtctccgc cttgttcacc gctcttggtc acaccatttc tgtgcacttc attgaaagct 3296641 ttcgcgaatt caagcgccat attgtcaaga tcagaaagca tttccgggta tacgcccttt 3296701 tcttggccat ctgctgttat atacccataa gactctataa accctaaaag ggatcccttg 3296761 ctgctaaagg actccgcctg tacagctgta tccccgattg aaatacttga tactaaccca 3296821 gtttcattat catagttggc tgcaagttct gaaacctcgt aatttttacc gtccaaaaca 3296881 gttcctagcg actgtttatt tttatcaagg atttcaattg atacagttcc ttcagcagat 3296941 gcaagtgcat tcccgcctga tttgttgtag ctgactttga tatcaaccat tgaggataat 3297001 ttatcgatca gcaaatctcg ctggtcatat aagccattcg gaagaagccc gaccggctct 3297061 acttgtgcaa tttgcttatt taaactgttt aactgagaaa gcagagaatt gacatccaac 3297121 acagttgtat ttagctctgc ttttaaattc gattggacat ttgtaagtga ttcagaaata 3297181 taattaaacg tttcagctac agcttgtcct tttcgagcaa caacagaacg tgcactttct 3297241 tcatttgtat tattcgataa ttcctgcagg gaattccaaa acgaattgag cacactgttc 3297301 aagccgctgt catccgtttc atttaaaacg ccttccattt gggacagcgc ttttgccttc 3297361 gtgtcatagt atccggcact gttgttttga agacggtatt ggtagtcaag aaagatatct 3297421 cttattctct caactgattt tccttgaacg cccgtaccca tttgtcccgc tgttttttct 3297481 gcatttttag atacagcagg gaaatagtca gttgcctcca atgagacccg ctgtcttgta 3297541 taaccatcag tattggcatt tgccacgtta tttgcagtag tgcttaacgc tgcctgctga 3297601 gcgcttaacg cccgccttgc agtttcaagc cccataaagg tagatgtcat tttctgaatt 3297661 cctttctgct aagcttttga atcaaacagt ttcattttgc tacttttcgg cagctcagct 3297721 ttaattgatt tgctgtaatt gaagttattt tccttaggaa ccagcatatc gtacgaaata 3297781 gagatgaatt gcagcgcgtc tcttgtcagc tgcctattca tctcatttac ttttttcaga 3297841 cgtccgagaa cttgagaaag agattcgtat agttgttcca gctcttcctt ttcactgcct 3297901 gaggttttgg cgatacatgc ggaaatagta ttattttcgc tatatccgag aaaggccgaa 3297961 gttgttttga tccggtcatc ttctgtctgc gtgattgctt gaatatattt ttgctctttt 3298021 gtcaaaatgt tagaaagctc ttttgttttg ccggctttga gcgcttccgt cttttcttca 3298081 gacagcgtga gcaggtgctc atgcagaacg caaagtcgct tcaattgttc aataattgcc 3298141 ttcgctgaca tgggctttct ccttttttat tgctttttat aaaaattaat catatttttc 3298201 gcaatatgat ttgcgtctac tttgtatgac ccgttttcaa tttgcgcttt aagctgcgca 3298261 attttttcct gtcgtgaacc agtgactgcg tcggatgcat gttgcatttc tttagcctgt 3298321 gatgaaattt caattttatc ttgaggttgt gcaacagttt tttgcaccgc ttgcttatca 3298381 taattttttt gatatggatt aacggattgt gttccaaatt gattgatttt cataggattc 3298441 ctctcgcttt ccgttgcagt ctttaaacaa tcttaaccct tttatcgact gcgttttcag 3298501 ttagtttagg gaatcagctg tttttggtat tataggcata gtatgtgtct tttttactat 3298561 tttctttctc gattttcaga gcatcctcgt ggttcaaatg atccatttga tccttaatat 3298621 cagactggca agccttgcag aacttgcctt ctctaatcga tgtcccgcac ctttcacaag 3298681 ggtatgccaa attaggaaga tgagtgatct gaattcgctt ctgcctgatg aatttcaata 3298741 tcagctcttc ttccacacct gtttcctcag ttatccggct caaagttgat tgccggtttt 3298801 cctgttttct taaaaattta tagacagtct caaatgattt ttcttcttcc ttaatacacg 3298861 cctgacatac ggtttgcagc tttgttttta aaaataaagc attgcatttc ggacaattag 3298921 ccagttctcc catctttttt tctccttatt agataatatg cctgtgtcaa tttctagtga 3298981 ttatatcggc ataaaaacag aatcatttag cttctgatca aggtaaaaga tgacactgaa 3299041 gcggcttttc ctttttctaa taagcagcgg gctgcgaagt gcaaggtggc gcctgttgta 3299101 taaagatcgt ctattaaaat gatattcata ccttctgctg aattattttt tgtatcaaaa 3299161 atgcactctg acagcaggcg ttctgttttc tttttctttg actgtttctc attattcagg 3299221 cgaatgaggg gatggtggga aggccggtct aaacattctg ccaagagatg tgcctggtta 3299281 aatccgcgct cttcttcccg ttccttgctc agcggaatag gtacaagaac aaaatgctta 3299341 tcggggtaaa ccttagaaaa ggttgaagaa aaatcacttt taaatgcatt tatgatttct 3299401 gcatctcctc taaatttaaa acgggagagc gtttctttca tcatatcatt atatgtgtaa 3299461 actgaacggt tttgacgcaa tagcaaactg tctctgatcc ttgttctcca cacctcgcaa 3299521 tccctgcata cggcatgaac agattgaggt ctgccgcaca gggggcagat atgtcctgtg 3299581 attttcttta atttgcttct gcaagaataa caaacctttt catcaggctt tagtaaaaaa 3299641 agggctctcc atgtaacatc ttgagaaaat tgcgaatcac ataataaaca gatcagttta 3299701 tgaatgcctc ctcctgcttc gtttgacata aatcgcttgg actctctgaa actactgcag 3299761 cagattcagc caaaatgaca agcattgctg tgtttttttg tttatctacc agctcagctt 3299821 tcgtatatgc gatcttttta aaatcagtaa cgtaggatgg actcactttg tttaaagaaa 3299881 gtgccaatac atcgttttgg catacttggc aagtacaggc catatgaagc tggtccatat 3299941 atcggtcgag cagttctttc attacgattt cttttgaatt gacaagcatt tttacagctc 3300001 ctcatcatcg gttatatgag tatactgtac cacgttttca aataatggct agtctgtaca 3300061 ttcaactttt gctgccaatt cattcatttc ttttatatgc tttcttgcat cgagcatact 3300121 ctttgttttg ccgaagtgaa agtaaatgac atcgccgtcc gcatattctt tatgccggcc 3300181 ggttcttcct gcaatttgaa caagtgcgct ttccgtaaag atagacgatt ccgctcctag 3300241 tacacccgtt tgcaccttgg ggactgtgac gcctctttcc agtattgttg ttgtgattaa 3300301 tagatcgagc tgaccatctc tgaattgctg cactttctcc tttctatgct tgtcttccgc 3300361 gtgcacagat gcggttcggc aatgaacacc tttaaagcac gcagcagcct tttccagaat 3300421 agaaacggaa ggaacgaata aaaaaacagg cctcccttct tttacatgaa actctatcca 3300481 tcttttcacc gctggcggaa ttttatttcg gtttaatttc ttcttccagt ttccacacca 3300541 tacaaagcgc ggttcgggta aaggtttccg gtggtgtctt gcggggatgc gaactgaatg 3300601 taactgtccg ttcagtgctt ttctttttaa ttctttagga ggtgttgcac ttaaataaac 3300661 gagggtgctg tttttctttc ttgctttttg aacagcgaat tgaagggttt gatcagcaga 3300721 atatggaaaa gcgtcaactt catcaatgat cataacatcg attgcatctt tatatcgcaa 3300781 aagctgatgc gtagtggaaa tcataagcgg agatagccgc cctttgtcat cgcttcctcc 3300841 gtaaagcgct gaaatgtcag caccctgaaa ggcagccttg agtcttggag caagctctaa 3300901 tacaacatcg gtgcgaggtg ttgcaataca tacacgcagt ccttgattta acgctgattc 3300961 tataccagga aacagcattt ctgttttgcc agcgccgcaa accgcccaga tgaggagctc 3301021 ttcttttttt gatattgctt caattaaaac attggcggct ttttgctgtc cgcttgaaag 3301081 cttgccatcc catgtcagct taatagactt ccagtttgat tcattttcct ctttccatga 3301141 atataaagga acctcctcac tcactctgcc catcatgaca caggaacggc aatacagctt 3301201 attctttcca gatgagtgat aaaaagaaaa ataccgctga tcagtttgtc cgcacctatt 3301261 acatctatat ctccgtttat ttatggatat agaattttca gcagtgatat atccattctt 3301321 gatatgccat tcaatcatct catcggaaaa tgagagctca gtcctgagca aatgacggct 3301381 tcgaagcgtc tgctgcaatt cttttgaaaa ggaactgttt ttttcaactg gcacattcac 3301441 atagcacgcc tcctttcgaa acagtatgcc tgaatgaata ttttctgtcc aactattaaa 3301501 ataagaatat aaaaaaatct ccgctctaaa aacggagatt tggccttatt taaaacacca 3301561 gcaaattcct aacgcacctt cacccaaatg agtgccgatt accgcgccaa aatagctgtt 3301621 ataaaattca acatgaggat attttgcaga aagctcttca atgattttcg ctgcttcttc 3301681 ctctcgatta gcgtggataa cagcagctcg cataggcaac cctttactcg catcttcgtc 3301741 taaaagctca taaattcgcg aaattgcttt tttacgtgtg cgaatcttct caaaaggcac 3301801 aattacctta ttgtcaaaat gaaggatagg ctttaccttt agaagactac caatgaaggc 3301861 ttgggcgctg cttaatcgcc cgccgcgctg aagatgggct aagtcatcta ccataaaata 3301921 agctcgaact gtttttttca tttcttccag ttcttttata atatcttccg gcgatgatgc 3301981 tccgtttttg attaattcag cagctttaag ggcataaaag ccttgagcca agcagctgat 3302041 ctctgagtca aatggataca catcaatatt gtcgaccatc gaatcagccg ctgctgcact 3302101 gctgaatgtt ccgctgatcc cgctggaaag atggatactg ataaccgcat cataagactt 3302161 gccaagctct tcatacaacg caaccagctc gccgattggc ggctgagaag tcgtcgggag 3302221 ctcattatgt tttttcactt cttcataaaa gcttttccag tccaactcaa tttcttcacg 3302281 gtaagtctcc tccctaaaaa caacctggag agggatcata tgtatctgat gttgttcacg 3302341 catttctttc ggaatatatg ccgtgctgtc tgttacgact gcaatattca tagcttcgat 3302401 acctgcctta ttgctttata actctattgt aagggaaacg gcagcctaaa aaaagacctg 3302461 cctagtaaaa ggcaagtctc ctattatact atctcatttc tacccagcca tttttaatgg 3302521 cgaccacaac ggcttgcgtc cggtcgttta cattcatttt ttgtaaaata ttgctgacat 3302581 ggtttttaac ggttttctca ctgataaaca atgattcacc aataccgcgg ttgctttttc 3302641 cgtctgcaag catctgcagc acttcacatt cccgcctagt taaaatatgt aatggtctgc 3302701 ggatttcagg gtaaacctca tgttgagggt gtgcagaaac tccgcttgtt gcaaggcggc 3302761 ggaattcgtt aacgaggttg tgagtaacct tcggatggag gtaagatccg ccctcagcca 3302821 ctactttaac cgcttcaatt aatgtatcag catccatctc tttcagcaga taacctcttg 3302881 cacctgtttt cagggcatgt gttacataat tttcgtcatc gtgaattgat agaataatta 3302941 ctttagattc aggatacagc tctacaagct gttttgtagc ttccacacca tttacgtttg 3303001 gcatattgat atccatgatc acaacatcag gatgatagtg ctcaacaata cgagccgctt 3303061 cgtccccgtc atcaccttcg gctaccactt caaaggtagg ttcaaaatcc aatatccgtt 3303121 taacaccttc acgaaataac tgatggtcgt cgataataac aatgtttact ttagtcacaa 3303181 gccacgcctc cttgtattat tgttctatat actctagcat tcggtcaata tgccttttgg 3303241 ctctatttta caaatcatag tcaaagagat aacggaacct taatcataat aaatgtccca 3303301 agacctattt tcgaatctat tgtcatcgtt ccttccaata aatctactct ttctttcatg 3303361 cccagcaagc cgaatgattt gtttttcttc tctttcgctt ccttcaggtc gaacccttta 3303421 ccgttatctt ttatcattaa aatcacaaaa tcctttgtga tctcaacttt gactgtaatt 3303481 tcttcagatt cagaatgctt tagcgcatta gacacagctt cctgtgcgag cctgaagagc 3303541 gcaacctcaa actgaggcgc tagcctctga tcctctgttt ctccaatgca ctgaaaatgt 3303601 attttgacct tcccgttata ttcctcggtt gtatatagat attttcttaa agttggaatc 3303661 aggcctaggt catcaagggc catcggtctt aaatcatata taatccttct cacttcgtaa 3303721 agggcattcc gaacattttg gcggagattt ttaatttctt ggaatccgtc ctctgcgccc 3303781 cggtcacgga aaatccgctc gattaattcc gatctcatca taacattcgc cagcatttga 3303841 gcgggtccgt catggatttc tcttgagact ctttttcgct cttcttcctg cgcctcaata 3303901 attcttaagc cgaaatcctg ttttgcctga gcatcagcaa gaagcagtcc aacttcgcgc 3303961 aaatcctgat tcaagtagtt gagcacaact gtaatttggc ttactaatga ttctgaccgc 3304021 tcaatgattt cctgaagccc tagcaatctg cgctccaaat cgtcccgccg ttcgcgcaat 3304081 tgcttctcac gctgctggat catcgtcaat tctacctgca gcttatgggc tttttcataa 3304141 gcattgcgga tttcctcttc actgaatcta tgaaaattac ggctgacctc ggataaacgg 3304201 tttctcgcat ggcgagtttg cacttcaagt ttatcgccaa gctcaatcac ttcatacacc 3304261 tgctgtttaa tttgtttcag ttcttcgacc agctgttcat actgctggcg tgactgctcc 3304321 ccgatttgaa aaacctcgtc cttgctcccg tcaacggttt tcagcatctt catcaaaata 3304381 gaatccagca ctttggaatc catctttgtt ttattcataa tttccctccg tcacggcgtt 3304441 gtcatatatt tttattataa atgtaattga tctgcaaatt atgtcgaatt ataatgaaag 3304501 aatgcgtata ttctagaaaa aaacattttt atatactatc tactctttat gataccaaaa 3304561 tacgcacaaa aattctaaag actgtacgaa tttgtatagg cagtctttta tgcttagcag 3304621 gagggtcagc tagcatgctg cacagctatt ttactgtgaa agaagcggga gaacacgaga 3304681 ttgttataga aaaatcgcgt tttatctgtc atttaagccg tgtttctacc gaacaagagg 3304741 cacaggaatt tatacagaaa ataaagaaac agcactggaa tgcgactcat aattgctcgg 3304801 cttatgttat tggcgagaat gatcatatcc aaaaagccaa tgatgacggg gaaccaagcg 3304861 gtacagcggg agtgccgatg ctcgaggttt taaaaaaacg caggctgaag gatacttgcg 3304921 ccgtcgttac acgctacttc ggaggcatta agcttggtgc tggcggatta attcgcgctt 3304981 atgggaaatc agtgtctgaa ggattaaatc atataggtgt tgtagaacgg aagcttatgc 3305041 gaatcatgca tacttctgca gattacacat ggcttggcaa gattgaaaat gaattaaggg 3305101 agtcacaatt tctgttaaag gaaatccatt attcagaaaa tgttgaattc gaaacatacg 3305161 tggaagaaaa agaaaccaac gctttttctg aatggatgac agaactgaca aatggaaaga 3305221 gtgatattaa agagggagag ttgacgtatc ttgaaaaagc cgtcaatcac ataaaggaga 3305281 ctgaataatg gctgaacgcg ttagagtgcg tgtgcgaaaa aagaaaaaga gcaaacgtag 3305341 gaaaatttta aaaagaataa tgttattgtt cgcccttgca ctattggtag ttgtagggct 3305401 tggcgggtat aaactttata aaaccattaa cgctgcggat gaatcgtacg atgccctatc 3305461 ccgcgggaat aaatcaaatc ttcgcaacga agttgtagac atgaagaaaa aaccattttc 3305521 tattttattt atgggaatag aggattacgc gactaaagga caaaaaggga gatcagactc 3305581 tcttattgtt gttaccctgg atcccaaaaa taaaaccatg aaaatgctga gcattccgcg 3305641 tgacacacgt gtgcaattag ctggtgacac aacgggaagc aagacgaaga tcaatgccgc 3305701 ttacagcaaa ggcggtaaag atgaaacagt tgaaactgtt gaaaacttct tgcaaatccc 3305761 gatcgataaa tatgtcacag ttgattttga cggatttaaa gatgtgatta atgaagtcgg 3305821 cggtattgat gttgacgtgc ctttcgattt cgatgaaaaa agtgatgtag acgaaagcaa 3305881 acggatttac ttcaaaaaag gcgagatgca tttgaacggc gaagaagcct tagcatatgc 3305941 ccggatgaga aaacaggata aacgcggaga ctttggccgt aatgacagac aaaaacaaat 3306001 cttaaacgcg ctgattgacc gcatgtcaag tgcaagcaac attgctaaaa ttgataaaat 3306061 cgcagaaaaa gccagcgaaa acgttgaaac caatattcgc attactgaag gtttagcgct 3306121 tcagcagatt tacagcggct ttaccagcaa aaaaatcgac acattgagca ttacaggttc 3306181 tgatttgtat ttagggccta acaacacata ttactttgaa cctgatgcta caaatctcga 3306241 gaaagtcaga aaaacgcttc aagagcattt agattatact cctgatacaa gcactggcac 3306301 ttccggtacc gaagacggga ctgacagctc aagcagttct ggcagcactg gcagcactgg 3306361 cacaacaact gacgggacga cgaacggaag cagctattcg aatgacagca gcacaagctc 3306421 aaacaacagt acaacgaatt caacaactga ttcatcctat taaaaaatgc ccggtccttt 3306481 tagaggatcg ggcatttttg cgcagaaaaa aactccggca cataagccgg agtttttaat 3306541 tccttttcac cagccgttta taaaactttg taaacggctt aaatttttca ttcacgagtc 3306601 ctgtcacttc tgctatgatt tgcataaaaa taatcaaaat gaagataata aacaaagaaa 3306661 gccaaattgt ggcactttta agtacaatcg cactgatact gaaaataaat ccaattaaat 3306721 aaataactaa gaccgacatc cgatgtgaaa ggccaaaggc catcagtcta tggtgaatat 3306781 gcgacttatc aggcgctgaa atcggctgtt tgtttaatat tcttctgatg atagcaaatg 3306841 ttgtatcaaa aatcggtacg cctaatataa taatcgggat aacgatactg aacaatgtga 3306901 cacttttata caggcctaat aatgaaagaa tcgagatact ataccctaaa aacagtgatc 3306961 ccgtatctcc cataaagatt tttgccggat ggaagttgta aaacaaaaac cccagcgtgc 3307021 tggcaataac gactaatgag agtgacagaa tgagcacttt tccgccggat agcgccatga 3307081 cagcaatcgt tgacaggccg ataacagaaa gaccggcagc aaggccatcc aatccatcaa 3307141 tcaggttaat tgcgttcgtg atgccgacaa tccataatac cgtcagcgga taagccatcc 3307201 atcctaactc aaatcgttct gttaaaaaag gtactgagaa aaagtccatt tttaagccag 3307261 tgcttacaat cataatggct acacctaatt gaatcaaaaa cttaactttt gcacttaatt 3307321 gatatttatc gtcaagaata cctaacacaa taatgatgaa tgctccgact gtaattgccg 3307381 tcatccttgt ttctgtgtaa ataccggatg caagcacgcc tgcaaccacc ccgataaata 3307441 tggccagccc gcccatgcgg ggcatgattt tgtcatgtac ttttcgattg ctgggctggt 3307501 caactgcacc tattttaatc gcaatccttt ttacgattgg ggttatgatt aaaactgtca 3307561 gcagcgagac aataaacgca acaacaatgc gaatcatgcg ttcgtcaagc ataaagaagt 3307621 ctcctttgga attaaatgaa gtctttattt atatagagaa ccgttccttc cattatacct 3307681 tctccttagt tattataaca agcttcatca aaaagaaaca cgtataatca aaaaacgcgc 3307741 atcccaattt ataggactac gcatgttttt gaatccctgt atatttcata atttgtctaa 3307801 ataagcaatt ccaatcttgt gtccgggcga tgtttcggcg catttcttta taggtctcgt 3307861 ctccgttttg accgagaact ttttcacaag cggctataaa atcaatcgga tgatcgccct 3307921 ctacatattc gtatacatac ggcttttgca tttttgaggt tgacggaaga ttagtgccta 3307981 caacaggttt tcctgccgct aaaaattcaa atagtttcag cggaaacaca gcttgattat 3308041 acggtgattg tttatatggc ataatgccaa tgtcgataag ctccatataa tgaggcactt 3308101 cttttggatc tgccggaccg gtccatatga cattgggaag cctcagcagc tcttgaaacg 3308161 aaacatcacc attggtggca tccgggccaa cccataaaaa tgtccaatca ggcttttgca 3308221 gtgccgcttc tttaatcatt ttaaaatcga gcttcggttt aatcccgcca ataaaaccta 3308281 acactattcc ttctctcccc tgcagtatac tgcgatcggg agcttgttta tttgcagaaa 3308341 acagctcata ctccacaccg ttttccacag tatgaacctt ttctcgtcct gcagtcagtt 3308401 ttttgtctac ttccttgtga agataatctg atgaacaggt tattgaatct gctcgttgta 3308461 taattctcag ctctgccgat ttaatgactt ttcgccggaa ttcagacagc agatttgatc 3308521 ggccgctgat cggcgcagcc cataggtcac tgcagtcata aatgacctga tcccaagaat 3308581 acagcgaaga cagcagcggg aatccgggaa acgtgtacca taaacagcag cgttcaccgt 3308641 ttgcagaagc aggtgtaagc tcatcgagta atggggagag cttatgtctg taaaagacat 3308701 ctgtatatcg tccgaaacga aacatttttt tctgcagcag gtctttgaca gcgaattgcc 3308761 tgatgccaga atggacttcc tgaaactctt tcccttgggc acgcggagcc ggacataccc 3308821 aaataacttc cttcgtttcc tcctgagcag ctaaaaattc tgccagccgg tgccttctgt 3308881 atctcaattg gtcttttccc cattcagcag tggcaacgat gacatgaatg attgcttctt 3308941 ttgtttccac cttcatcacc ttttctctct gtttgcagct ataatctttt tttcaccgcg 3309001 ttttttgcat attgaacaaa acaccatgtt gctttcataa aatgaagccg ttcgatctcc 3309061 ctgtagacaa accacgtttt tttcgcagcc ttccatttgt tgctggaaat tgaattattg 3309121 acaagccgat attcagccag gcattcattc attccatagg cagtaaatcc tttttttaaa 3309181 agagacagcc atgtggctaa gtcctgtctc gttctgatat tcggcatttg gatctgtccc 3309241 gtttgctccc tgtcaatcat caccgtcaag cagccgataa ttgtattttt cagggcgtca 3309301 tcgtacgtca ggctttccgg cgcatgaata aatttatcga gcggggtccc gtcctgcgcc 3309361 attaagctgt agcccgtgaa agagaacgca caggagcgct ccatcataaa ctcaagctgc 3309421 ttttccagtt tgtctttttt ccatttgtca tcactgtcca aaaatgctac gtagcgccct 3309481 tgagcgcgtt ccaacgcttt gttgcgagca accgcagctc cggagttctc ttccagatac 3309541 accacatgaa ttctttcgtc tattttttca tactgctgta aaatgtcgcg ggtcccatcc 3309601 gttgagcaat catccacgat aatcatttcc caatgaggat ggctctgatc taataccgaa 3309661 tgaaccgtgt cttcaatata gtcacgcgca ttataggaag gtgtaatgac agatacgaga 3309721 ggtttccaat tggtcatgat cacatctcca tcgtatgatt ttaaaaggat tctctgaaaa 3309781 attcaggaat gacaacgaac ataaaggcaa tcgtaaggcc aatcataacg ccgagaactg 3309841 ctttcttttt cggagacata ccgccgcctg ctgtctcact tacggtttcg gaatcagtaa 3309901 cacttgccgc tttcaggtta agctgtgtgt ttttgagttc atataaaaat ctctctttat 3309961 ccactttgga atcctcgctc accgactcgc cttcaagcgc gtctatgctg ctgcggatga 3310021 cggcttctct ttctgcatac agcttttgat cgtttttgag gaaggtggag gatatggcgt 3310081 ttaagacaga ttccgttcta tccttatcct cgtcactata gcttaaagtc agtaacgatt 3310141 tggattccgt attgattgta agcttctctt tgatctctgc tacatcttca tccttttcat 3310201 caggaagcgc ctccttcaaa aaggagtcgc tctttaatag aagcggaatc tcttctgtgc 3310261 tgttataaac cggatgatca tagctcccca cagccaaagt atcttcagct gtatagctct 3310321 tttgatcagc gatctgtgac ggcaggatat accccgccgc acctaatata attggcaccg 3310381 ctatgatcca aatgatattt ttttttatgc gacgggctat tcttatcaat atatcgttca 3310441 tataagtctc cctgcttttt gtagtctgtt tatctgtaca tcggctcagg catttgtctg 3310501 gatcgcctta acacattcac ggcggcgatg acgagcgcca taaacaccca atggaaaaat 3310561 aaatttgaaa cagagcttgg gctgatactt gataccagga aactgaccat agcggtaata 3310621 agtccttctg tgatcagttt tgactgattt tctaattttc tttcataaaa cttgtaaagc 3310681 acccatatga ggtaggcata aacggacaaa tatcccagca tgatgaacaa accaaaatta 3310741 gcaagaattt caacaagcca gttatgcacc tctgccacat tgtcagtatc atatacagca 3310801 taatgctcaa gataatagga tacatttcct gccccgactc cgaatccgta tgaatcaagg 3310861 aaaaaatgcc aagcgttttt cagcagattt gcccgagcca catttgatgg aagcctgtca 3310921 tgaaatgaat gcagcgtctg cggggccaga aacagctccc aaaactttga atagattttg 3310981 ctggcgaaaa gaactgcgaa aagagcaatt cccgccgccg acagccatat agccattctc 3311041 tttaaaacag gcggcaatac aatgaagatg tagacagcaa tacctgcaaa aatgcccaga 3311101 aggctggctc ttgaaccagt ggcaaaaatt aaatacaacg cacagagcga gagcacaagg 3311161 ccaattgcct tgatgtatcc attcttaatg tttttcatca tcgtgatgta aaaaaagaag 3311221 ctgatggata aaaaggtcgc aaagtcattt tgattaaaaa agaccgatgt cggataatgc 3311281 tgcttgtact ccggtccgct gtacaatgtg gaactcgcaa gatgatggtg ggtgatatga 3311341 ttgtaaaaac caatgatcat cagaaatacc gtcatcacca gccaaatggc ataaacaatc 3311401 atcagccgct ccattttttg cacgtacatg acaataagat aaatgaagaa gatccccatt 3311461 gccaataagg ctaaatactt gaggccaact gttaccgact tggcccacag cagagaaaca 3311521 aggccatata taaaccaaaa ggcgaaaaag agtaaaatcc cttttacttg cagcccatgc 3311581 catctttcaa tatgggttcg attccgaacc atgccgaaaa tatgaaggca acccgctgca 3311641 atgagcagaa gccggtaaag gaacaaactg aaaaatccaa gatgaatggc aaaaaatgca 3311701 ttatttaaaa aagtgcaggc gatcaaaata tagattacag ccataaagag ccgttctttt 3311761 gttgtaaatg cggttgcaag cgtcagtaaa aacaggccaa ttgccaacac cgcaagcaca 3311821 gcagccatct gcatgaaacc tatatcttta tggatggctc ccagcaatag gacgactcca 3311881 aatatagcag cggccagtaa cgctagcgta tggaccgctg atcgtttgat actcacatgt 3311941 ttaacccctt tcctgatgtt tcaggagccg gcggccgagc ctagcagccg gcagcttcaa 3312001 ccaagtaaca ctttttcttt ttataaattg acgcttccca agtctttagc caattcttca 3312061 agcggcaagc ccggaaaata cttgtcagag ggttccgttc cccgaacagc gggacggccg 3312121 atagagtgat aaatgtatcc ggctgcctgc atctcttcaa gtgaaaataa atttctgccg 3312181 tcaatgatga ctggctgttt taagagggtt ttcactttta caagctccat ttctttcact 3312241 tccggccaat ccgttaaaat caggcatgca tcagtgtctt ccatcgcagc atacacatct 3312301 gtgtaatact cgacctgttc gccaaggatc gctgaagctt caggaatagc aatcggatcg 3312361 tatgctttta catgggcgcc cagctgctgc agcattggga taatatcaag cgctggagcg 3312421 gatctcacat cgttcgtatt cggtttgaag gctaatccca ggactgaaat ggttctccct 3312481 ttgacgcttc ccataacagt caaaagttta tctacaatat gaacacgctg cttttcgttc 3312541 gtttcaatga cagcttcgat gagcttgaat ggatagcctg ccgattttgc gatttgaagc 3312601 agcgcggttg tatcctttgg aaaacatgaa ccgccgaatc caataccagc tttaaggaac 3312661 tttctgccga tacggctgtc aagaccaaca ccatcagcaa cttttgaaac gtctgcgccg 3312721 actcgctcac aaatgtttgc gatatcgttg ataaaggaaa tctttgtcgc cagaaatgca 3312781 ttcgcggcgt atttaatcat ttctgcactt tctaggtttg ttttaatgac aggagcatgg 3312841 aatggctgat gaagttcctc aatgatggca gcggctttat gacttgttga accaatcacg 3312901 gcacgctcca tattcatcgt gtcatgaatc gctgaccctt cccgaaggaa ttcagggtta 3312961 gatacaacat caaatgagta tctccccttt gaggcttttt gaacgataga ttgcaccagt 3313021 ttccctgttc caaccgggac tgtgctttta tttacgatca ctttgtagcc gttaagatgc 3313081 tcaccgattg ttttcgccgc cgctttgacg tacgttaaat cagcttcacc tgttttggac 3313141 ataggcgttc cgactgcaat ataaataata tctgaggccc gaatggcaga cgggatatcg 3313201 ttcgtaaagg tcaggcgctg atccagcaca tttttttcaa ctaagtctgc aagccctggt 3313261 tcatagattg ggattacccc atttttcagg cttctgattt ttgattcatc gatatcacag 3313321 caaacaactt tattgccgat ctccgcaaag caagtgcctg atacgagtcc tacataacct 3313381 gttccaatga cagctatttt tttcacagcg ctcaaccctc tcctgtaaaa tgatcttcca 3313441 atttataatg gtcgcagtgt cttacgatta aacggacgtt ttcgtgaccg tctgatactg 3313501 atgatgcaag gccttggcgt tttttcctgc gtcaaattga gcctgcacgg tttcatacaa 3313561 gtcatctgct acttccggct tccatatttg ctcatgttcg taccgagtga tcgcttccgc 3313621 caaggcttga gcggatttcg gtttaatcag cagatgttgg tgctttccga ataaagacga 3313681 cactccgcca acatccgtac aaataacagg aacccttagc gccagcgcct caatcacaac 3313741 agtcggcatc ccctcactgt aagaaggaag tacgaataga tctgccgcaa gtaaatagtc 3313801 tcttacctga tgattcggga cttggcctgt gacgatatgc cccttctgcg tcagcgtcga 3313861 ttttgcggga ccatccccga caaagactgc cttaggagag tcctgcagcg attcgatcgc 3313921 ttcagacagt tcaaaaatgc ctttctctct gaccagccgg ccgacataga cagccagacg 3313981 ctgatcgagc gggagtccga gtctttttct gatttcctct ttcgtctcct cattcccctg 3314041 aaaacggctg agctgtatgc cgattggcaa aaccgagctg tcaaagcccg aaagcttttt 3314101 ggcttcttcc tgaagcttgt ggctgactgc taaaacaact gacgcagaac ctacggcacg 3314161 cttgaaggct ttaaacgcac ctttgctgta atgcggatag acattcacat cactgccatg 3314221 caaggtcagg acataaggaa tttgcgctga ctctgacacg actgccgcag ccccgcccga 3314281 tggcatggca aaatgcgcat ggatcagatc cggatatagg tcgcgctgtt tcattgtttt 3314341 taaaacggct gatgcgattc tccgatgagg ctgcgcccac ttcagctggc cgggaactgc 3314401 ccgatagaaa ggccggtaaa ccggtatccc ctttctaatc tcatactccg gtctgacatc 3314461 cttttttcga tatgtctttt tcagcatgcg gacaggtgct gaatgaaaag gccgtgggca 3314521 tatcacagtg atatcaagcc cgagtttttg cagctcttgc acctgtgtct catgaaacac 3314581 accctctccg ggtttcatac tgctcggata tacgcttgtg atccacaaaa tcttcatgac 3314641 aaacgtcctt ttcttagtag tttgcttttc gtttgagggt acgcttttac caaaagaaag 3314701 agatagcaca gcgccccagc cgcaactgaa atggccagcc gcatttctgc ctgcatactg 3314761 aagtgttcgg tactgaggct tacaccaaac gcgatgatgc ccatcgccgc agtaatcaga 3314821 aatggcttca taatcgactg gaaataagct gaaaggttaa gcttgatgac atatgccaaa 3314881 agccagcgcc caatcaggaa attaacaacg ctgataatgg catacaccca tgcgactgtc 3314941 agcaggcttc ccgtctgtac agctgcaaac agtgataatc cgtacagcag cagcacgccg 3315001 gaatcccaat aaaacgctaa gtcagctctt cctttagcca gcaacacaga tccatttgga 3315061 ttcatgagca ctcttagtat tccgacaatc gcaagaacat ttaggatcgg aacagcagca 3315121 agccattttt ctccgaaaac cgctgtgata aaggcgtctg acacagacac gagcccgatt 3315181 aacagcggaa acgaaacaag cgccagcatt tttgtcatat tcagaaagcc ttctctgatc 3315241 acgctgtttt catatttgtt ttttgcgaaa atagggaatg ccacccgtgt gacaatcgga 3315301 ttgatcttca aaaccggaat ggtgacaatc tgataagcga ggttataaat ccccaatgct 3315361 tcagcaccaa taaaccggcc gatcaaaatc atgtcgatat ttgctcccag cctgttcaca 3315421 agacgggatg aaagctgaaa ggctccaaaa gaaaagaaat ccttcatgcc tctcaaatca 3315481 aaaacaaaag caggatgcca cttttttcgg tatacagccc aatataaaat ccctttactg 3315541 gactgcagca ggacttgaga aatcacgtac gccaaaatcg catccatcat aaaaaccgct 3315601 atcgctaaat atccgaatga caatacattt gaaaaaatct ctattttgct taacgtatta 3315661 aaatgcagct gcttttgcag catatactga tattgctgtc caattggcgc gatcaaaaac 3315721 ataatcgcca gaatccgaac cagaaacacc agctcttctc tttgataaaa tcccgcaatg 3315781 acaggactgc tcacatataa aagaacaaac agcaaaacgc ccgtcataat gttaagccaa 3315841 tacaatgttg acagctggcg ctccgtcgcg tcgtctctct gaattaatgc tgcgccaaaa 3315901 cccatatcga gcacaatctg ggcgaaaact gtaaccgttg tgatcatgcc gacaagccca 3315961 aattctgtta aggtcatcat atttccaagc agggcaaact gaacaatttg tatgattgta 3316021 atacacatgg ttgaaatact tgtccacttt gcaccgctca tgatttgttt tgtaatactt 3316081 ggcatcatat tccctacttc tttttaagct cagattgatg gtgaataatg gaatcccgtt 3316141 ttatcttgca ccatcacccg tccaaactac tttacaagtt tttaacataa tttttaattc 3316201 taaagtgaaa gtcagattgc gaatgtaata taaatcaaat atcagctttt ccttcggcgt 3316261 catatcgtaa ccgccgttca cctgagccca gacgctgtgt aaagcctgga atctcattct 3316321 ggaatttttc cgtaaatacg ggccgttccg gacgagggcc aatcatactc atatcgcctt 3316381 tcagcacatt aaacagctga ggaagctcgt caattctcgt tcttctgata aaagctccga 3316441 tccttgtcac ccgcggatct tgcttctgtg cccaaaccgc cccagacttc tcggcatcta 3316501 ttttcatgga acgaagctta taaagcttaa atggcttccc gcctttccct acgcgttcct 3316561 gcgtataaat ggcaggcccc ggcgtctcca aacaaatcaa aattgaaaat accgcaatca 3316621 ttggcagcgc aatcgccaat ccaatgagcg caaaccaaat atccattacg cgctttattg 3316681 ccaaataacg agccgtcttt tcagataatg taaaagaatg tatttgttga actgagaatt 3316741 cacgactcac attcatgctt ttctctgcac tcactgacac acacctcacg atttgtttgg 3316801 gatgttatga tgacctatgc cagtcagttt agcagacgga tgttaattgg atgtaaatgg 3316861 tatgttaaga agtgtgaatt acgtgttttt tctgataaat gttgttaata ctcttttact 3316921 attttatata caagtcctat ttgttttaat catttcatat aaaaaagaga caaatctgtg 3316981 attagatttg tctctttcga ttatctgtaa taagatactg tgccgtcatg aatagcttgt 3317041 gcagctttat ctttataaac cgcttgcttc aatttacttg catctgatgc attagtgata 3317101 aaggcagttt caactaaaac actcggcatt ttagaatatt taataacata gaaagcagct 3317161 gtttttactc cccggtctct cgttccaaga ttagccgcta actttggttg aatttgttca 3317221 gccagtctct tgctatttgc agcttgatat gttgtatcgt agtacgtctc acttccattt 3317281 ggtgatgagc tatcattagc atttgcatgt atactgagaa ataaatctgc ttgtgcagaa 3317341 gctgctttat ttactctctc ctgtaaagaa taaaaagtat cattagatct tgacagtact 3317401 ggaagagcac ctgaagcatt tagctttgta ttgactcttt tcgctatatc aaggttgact 3317461 tctttctcaa ggagtccatt gccgattgct cctgaatctt gatcaccgtg acccggatca 3317521 ataaagattg tttcacctac aactggattc tttagctgat tagcaacctt tgtgcttacg 3317581 gcaggagtgt ttccgataat cataaagttt gacatgtttt tacttccaat aattttacgg 3317641 gctcctgtag ataaattttc accatttgta agaataagag attgcttctt cttagctgcc 3317701 agtgtagctc ctgcaataga gtcagggtag ctgaatccat tgcttacata tacggtgctt 3317761 gttgataaat taagtttttg tacgatattt gcagcaagct catatctgtt tgaaccgcta 3317821 attcttgtag gagaaggtaa cttgttgtat accgtattgc tgatacttcc agtgcctcct 3317881 acaacaacgg tactcgaaat tcccttatct tttatcacag acgtagtcgc actatttata 3317941 gatgttttat ttgtaaaaag aattggatac ccgtttttcg ctgcataagg gatgacggcc 3318001 ggagcgtctg catataagaa gccgttcaaa ataacagctt ttgaagtcgc acccatcgct 3318061 tttgccaccc gtgcagccgt atcataacgg ttgcttcctg caattcgttt aatacttatc 3318121 cccaagcttt taatctggtt agcagtgtta gaagaaacag caggtgttcc gcctacaata 3318181 attacatttt tagtctgcat ctctttcaat cttgttttcg tttcatatga aagcttatca 3318241 gaattagtgt aaagcaatgg cgcattcttc tggtaagcaa gaggtgctgc tgaaatagca 3318301 tctgcatagg aactcccacc aacaattaca gctgtacttg ctgttgaata catttgcttt 3318361 gatatttgta cagcagtgcc gtatctattg cttcccccaa ctcttttcac tgagttatcg 3318421 gccaaagctg ttggcacaaa aagtatgagc cccagaaaac acattgttag gacttttata 3318481 taagaacgca attgatttcc tccttaaatg gcgttatatc ctaaaataat caataacttg 3318541 tcagagttgt acctggatag taaaatttca aaattgaact atatgaatct ccagcttctg 3318601 ctcttgcttt tgctccatat tgactcattc cgatcccgtg accatatcct ttaccgctga 3318661 ttgtgtactt tgaagtatct ttttttacag tcacataagt acttttaaat acagtcgctc 3318721 caatcattgt tcttaactca cttgttggta cactaatggt tgtaattttg ctcaagttat 3318781 aggagccagt actgctttta acaaaatact tcactttcat cgatgctgtt tttgcacgct 3318841 gcccttgtgt cgttccacta aagcttaaat cgtcaatact tgcaattttg acagaatcag 3318901 cgcttgtttc tttatttttc aagatccagt tcttaactcc ggaaagtctt gcagaatcag 3318961 tttcagtcgc tgaagaccac caagaagaag gcttcgttaa gtccaaagat ttcgtatcta 3319021 gctgttgttt tgacaaagta agcgtccagc ctatttgagg atcctttgta tctttttttg 3319081 caatcaagta aggtacactt gacgaccaca cttcattact agcttctgtg taaccaccat 3319141 tactggaaga ataagctgca gttataagag atccattata tttcagaact ttccccttcg 3319201 tttgctctac cgctttattg gtattcgaat tccaactgta gccaccataa acttgaaaag 3319261 cggttgtatc aggtacagta gttcctgttt ttgttattga gtaggttctt gcagcgacag 3319321 tctgtgcttt aagagcctca agtgaccagc tagcaggcat ttcattcgga attactcctt 3319381 ttaagtaatc ctcaaatgga atattctcat ttaccggtcg gatatattta gtagactcaa 3319441 tagagaaatt aaccgtgcca agatactgct ttccatcaag actaattctg tttgaagtag 3319501 aatagttttc tggtttaatt cttagggagt ttccgtaagt tttgatgttt tcaaggttta 3319561 attttccgct gttgattttt agattatagg tgccaccgtc agctaaataa aattcatcag 3319621 caagtgaatt ctcaacttca gcagaaattg aactggtact tccaataaag tcgtatgcat 3319681 atgtggcttt atctttcgtt atacttttag ccgcagccgg aacgctatct tgtttaacaa 3319741 ataaaatttg gctgtttttc ttcgaggcaa gcgaagcgcc tatcaatacg tctgcatatt 3319801 ttgtcccgtt cgtcattacg actttatcag ccttcaactt tagttgctta attatatttg 3319861 ccgtaagttc atatctggtt gatccaggaa tcctttgcac agttgaagtt tttttaattt 3319921 ggttttctac actatcactg acgctaaatg aactgcctat aatgatgact tgttttggca 3319981 aatcataatc cggaagcttg tctttctctg taagcaaaat agggtatccg tgtgctgctg 3320041 catatggagc aatggctaaa gcgtcttgaa atactcttcc ggttacaacg atcgctttat 3320101 catagctgcc catttgcttt gcaatatttt ctgataagac atatctattt tttccgctta 3320161 tccttttcac agcgccatat gatttcagct tgttttctac gtcttttgaa atgcttcgcg 3320221 ctcccccaat gattaaaata ttatcagggt taaacttagc aatttgtctt tcagtagttt 3320281 ttgttaacgt gtcaggctga gtaaataaaa ctggtgcgtt cagttttttc gccaatggaa 3320341 taacaggcaa tgcatcaata aaaatatctc ggttcaccaa tatcactgta ttaggatttt 3320401 tccactggct gttggatgca agagtcgcag tttcgtatcg tgaagcgcct gcaaaacgat 3320461 ccgtaacagc aacattatct ccagttactt tataaaatcc tgttggcgat agactgatgc 3320521 tagatttatt tccaatataa tttaacaatt taactgagat gtttgagtct gctgcaaaag 3320581 aaactgatgg aatcaataat aagattgcag caagtgaaca cactatcaat tgtttgcaag 3320641 atttcaaaat ttcaggttcc tccctatatc ttagttggca cgttcaatat cttttaacag 3320701 aagctgaccc tcatcatttt tttcatatgt aatcgtgacc ttatctccac tgttaaactt 3320761 atcaagatca cttgtcgatt cttcagtgat atcaagacta accggctcat tatctactgt 3320821 tacttctatt gtatgagtat cagctaaccc tacataagta ccttcttttg tttcaatgtt 3320881 actgtctggc gatacatctt caccttgact cttttgacta ttaaccccgc aacccgaaag 3320941 aagcaatata aagaacagta aagcaataaa ttttttcatt tttttcacct cattatattt 3321001 tatcgtcaac ctattttata ttttaaagaa aaattaagaa acaatgaaac ttttttttat 3321061 aaaaaacgac tattttagga tttcattctt gtattaaata gagttgtatt tattggaaat 3321121 ttaactcata atgaaagtaa tttaacagac gaggtgcaaa ggatgagaaa cgaacgcaga 3321181 aaaaagaaaa aaactttatt actgacaatt ttaacgataa tcggacttct tgtactcgga 3321241 actggcggct atgcatacta cttatggcat aaagcagctt caaccgtggc aagtattcat 3321301 gaaagcattg ataaatctaa aaagagggat aaagaggtca gtatcaataa aaaagatcct 3321361 ttttccgtct taatcatggg tgtggatgaa cgcgacggcg ataagggccg tgccgatacg 3321421 ctcatttata tgaccgttaa cccaaaaacg aatacaaccg acatggtcag cattccgcgt 3321481 gacacgtata caaaaattat cggaaaaggc acaatggata aaatcaacca ttcatacgct 3321541 ttcggcggca cacagatgac ggtagacact gttgagaact tcctcgatgt tccggttgat 3321601 tattttgtga aagtgaacat ggaaagcttt agagacgttg ttgatacact tggcggcatt 3321661 acagttaaca gcacattcgc gttcagttat gacggttatt cgttcggcaa aggagaaatc 3321721 acgctgaacg gaaaagaagc gctcgcttat acccggatga gaaaagaaga tccgagaggc 3321781 gacttcggac gccaggaccg ccagcgccaa gtcatccaag gtattattaa taaaggcgct 3321841 aatatttctt ccatcacgaa attcggagat atgtttaaag ttgttgaaaa taatgtgaaa 3321901 acgaacttga ccttcgataa catgtgggat atccagtccg attacaaagg tgcgcggaaa 3321961 catattaaac agcacgaact aaaaggtaca ggcacgaaaa tcaatggaat ttactactac 3322021 caagctgatg aaagcgccct ttccgatatt acaaaagagc tgaaggaaag cctcgaaaag 3322081 taaaacaaaa agaagcttcg cacaatgtgc aaagcttctt ttttatttgc ctgtaaatga 3322141 atccggttgt tcttttcgat acccgtaatg aaacagcaat tcttccacaa tccggcggga 3322201 agcctctcca tctccatacg gattagaagc ctgggacatt ttcttgtact catcaggatc 3322261 agttaacagc tgttttgcaa gctgataaat gttttcctca tccgtacctg caagtttcag 3322321 cgttcccgct tccactcctt caggccgttc cgtcgtatca cgcagaacaa gaaccggttt 3322381 cccgagagat ggggcttcct cctgcacgcc gcccgaatcg gtcaatataa aatgcgattt 3322441 cgctgcaaag ttatggaaat cgatcacctc taaaggttca atcagatgca ctctgtcaga 3322501 atcaccaaaa tgcttatgag ccgcttcccg gacaacagga ttcaggtgca cagggtaaac 3322561 gacttgtaca tcttcaaatt cccctacaat tctgcggatg gccttaaaca tgttttccat 3322621 tggctcaccc aaattttccc ggcggtgagc ggtcaagaga atcattttat cctcacccac 3322681 ctgatcgaga acaggatgtg agtaaccatc cctaaccgtt gtgttgagtg cgtcaatcgc 3322741 tgtattgccc gttacaaaaa tagagtcggc ctttttgttt tcttttaata aattgtcttt 3322801 cgcctggcct gtcggagcaa aatgcaaatc agcaatcgcc cctgtcatct gtcgattgag 3322861 ctcttccgga aacggggaat acttattccc tgtacggagc cccgcctcca catgaccgac 3322921 agcaatttga tggtaaaaag cggctaggct tccggcaaac gtcgtcgtcg tatcaccatg 3322981 gacaagcaca atatcgggtt tgatatcttt aaacaactca tccaatctta caagtgcgtt 3323041 agacgtaatc tctgccagtg tctgccgctc cttcataatg ttcaaatcga agtcaggctt 3323101 gatgtgaaac gcatctaaca cctgatcgag catctgtctg tgctgtgcag ttaccgttac 3323161 ataggaatct atttcaggat attttttcaa ttcaagcaca agcggtgcca tcttgatcgc 3323221 ttcaggcctg gtcccgaaaa cggtcatcac ttttagtttt ttcatatttg tcacctggtt 3323281 ttctgctata gtaaataaat tcatactaca tattctacat gaaaatgcat cattttaaat 3323341 catttcattc ttgattcaaa taaaatgata taagttttaa tattaaggat aaagcttgtt 3323401 taaaaatggt ttatccgata tcataaaaat gtgtaaaaac atattgaaaa gggtaaatag 3323461 agaatagttt aaccataaat tttttcgatc ataaggaagg tgccttttaa atgaaaaaag 3323521 tacgtaaagc cataattcca gcagcaggct taggaacacg ttttcttccg gctacgaaag 3323581 caatgccgaa agaaatgctt cctatcgttg ataaacctac cattcaatac ataattgaag 3323641 aagctgttga agccggtatt gaagatatta ttatcgtaac aggaaaaagc aagcgtgcga 3323701 ttgaggatca ttttgattac tctcctgagc ttgaaagaaa cctagaagaa aaaggaaaaa 3323761 ctgagctgct tgaaaaagtg aaaaaggctt ctaacctggc tgacattcac tatatccgcc 3323821 aaaaagaacc taaaggtctc ggacatgctg tctggtgcgc acgcaacttt atcggcgatg 3323881 agccgtttgc ggtactgctt ggtgacgata ttgttcaggc tgaaactcca gggttgcgcc 3323941 aattaatgga tgaatatgaa aaaacacttt cttctattat cggtgttcag caggtgcccg 3324001 aagaagaaac acaccgctac ggcattattg acccgctgac aagtgaaggc cgccgttatc 3324061 aggtgaaaaa cttcgttgaa aaaccgccta aaggcacagc accttctaat cttgccatct 3324121 taggccgtta cgtattcacg cctgagatct tcatgtattt agaagagcag caggttggcg 3324181 ccggcggaga aattcagctc acagacgcca ttcaaaagct gaatgaaatt caaagagtgt 3324241 ttgcttacga ttttgaaggc aagcgttatg atgttggtga aaagctcggc tttatcacaa 3324301 caactcttga atttgcgatg caggataaag agcttcgcga tcagctcgtt ccatttatgg 3324361 aaggtttact aaacaaagaa gaaatctaaa caaaaaggct attggacatt catccaatag 3324421 ccttttttta tttcaacatc aaagtcaatg tatgctcttc attatcaact gcgaagacct 3324481 gatcaacggc ctgccgcaaa aattaataat cccagacaaa cacactgatt gtagagttaa 3324541 acaaactaaa tgaaaacata aatacaaaca tgcagattaa atagtaaata tcttgtattc 3324601 aatgcaagct aagtaaacac cacttgctaa aagaacaatg actaaacaac cagcattaca 3324661 aaataattaa ataaatttga agcaattaca acagaaggca gtgaactgtc ggaaagttca 3324721 ttttggctac catattaatc cctttaacta cgctgttgga tttatcaaga attgtcgggc 3324781 taatagaaaa ccacggaatc aaaccagcca gcattcaaac gataaaaggc acttctccga 3324841 tacctgttat gaccagctta ctgttgcgca tcccaaatac aaaccagtac gccatcatta 3324901 gaataagggg atttaaaacc tgccataata caccaaaata attgattttt tggatctttc 3324961 ggttaaagaa atttaaaagt accagtgaat attgtaacaa atgttgagtt tttttcactt 3325021 ttaaaaagta aagagaagtc tcgcagaact tctcccaaca tttgaagtgt caatataaaa 3325081 caaaccaacc tcatttagca actttattat tatctaattc caaaatagca ttataaatac 3325141 gattcctatt atttttatca gtatatgcaa aaaagttatc tactcttttt ctatacttat 3325201 cttccatacg actattgttt ttcatataat agataacttt atccactaag ctattatgat 3325261 tttctaatac atcaccaaac cccatttttt tataatcata ataatcaagt ttaaaatggt 3325321 atgacttttc gtattgataa taaataacag gttttttctc atatgcaaaa tcaaacgcaa 3325381 cagatgaaaa atcagtaatc attatattag aagaattaaa tagcatttga tagctgctgt 3325441 tatagtcggc aaactccaca taatcatgct tttcaaagtc tacaatctgt tgctgaatat 3325501 ctgggtgagg aaaaaaagtt attttataat tatttttctt agcaaattcg attagccgtt 3325561 catcattaat caaagcatta tacctagaaa aatattcact atctttaaat ttcgggttgt 3325621 acggtcttac tccttttgcc tgatctttcg gtaatacaat atcttttctc caagtcggca 3325681 ttattagaag ttgcttttct ccctcactct tcttaagatt atcgtatctc ggaaatccac 3325741 ccaacaaaat attctctttt ttatagttgt aattcccttt cacaatagac cgatattcag 3325801 gtttggcaga agtgactaat aatttgatat tcttgttgta tttgtttaac cattcagaat 3325861 gatctgccat tgttattccg tgctgtaaaa agataaactc aaagttaaat aaatctctaa 3325921 aataaatctc catattaaaa aatggattta caacccatat atctgcatgt gtcgatatta 3325981 ctttggaaga ggataaggtt aaaattttat gtctaaaaga tctgtatggt atgacctttc 3326041 catatttttt gattctgtcg taatccttgc tatctttttt tattataaag tattttttta 3326101 ccccatcatt cttgttgatt gcatatttaa agaggtgctc ggcattatca tcagctttgt 3326161 cttgtctgtc tatgaataac catactggtt ttctattaaa aatagtgaaa acatggtgta 3326221 ccattcttgc catcagtgcc ttcttaatcg ctgattttcg tttttttgat ttttcccctg 3326281 atttatgtag ggattttaag aaacgaaact cttttataaa tctattttta aaattgtttt 3326341 ttttgaacat taatttttta taattataat aaaaaatata atctttttta gccacataag 3326401 tattatataa atcgtttgac aaacctgaat acttgaaaaa acgaagtttt gtcaacttcc 3326461 tttttttacc cttagttata aaaaactcaa tatgatgatt atctgctaga tgacctttgg 3326521 gaatatctat tgaaaaaccg ggatattttt ttattacttc tcctaaactt atataatcat 3326581 tatgctgtct ttttatattc tttgctttta tttttgtttc gccaatttta gcataaaact 3326641 taaaaccttt agaattaaac agcgagctcc aaaagccttc tatgtgaatg gaatcctcat 3326701 tttcttctaa aatttcaata gttaaagttt gatccgataa tttcgaaaca attttacctt 3326761 ctctgtataa ataataatcc tgttcagttt ctctttcata tacataccta ctataatttt 3326821 caccgtgctt tatttttaaa gcatgatata aatagaaatg gctgacactt tttgtttcaa 3326881 tgatgacatc gtcgtcaata tacgacaata cttctcgaat caatgttaaa aattcactgt 3326941 attcattttc gtctaaaggt gtttcactga tatccttaat caataatttc cacttcaaat 3327001 catgcataac catatattga agaaataaag gtattttctg ttcatgattt tttataatat 3327061 cgattaaatt ctttgagaaa gtgataagtg aatggttaaa ccaattctta tttgctttag 3327121 cagtctgcat ggcagatgat ccatcttctc taactctata atggtatttt gcctctttaa 3327181 ccagaccata ctttttcttt tgcgatatga ttaaattaac tagtttggca tcttcaccta 3327241 ttttacaatt ttcatcaaac ctgatatttt tcaaggcatc tttttttata aatgtagaac 3327301 aacaatgagt taatatatga tgcggttctt tttctacatc caaaattctt gtagaagaaa 3327361 acttattatt tagattatgt tctccagttc ttccttctgc aaaaaaaata gggattgcta 3327421 caatatcaat ttcattctta tgttcgtcaa agaagtttaa aacattttcg aatgttcctt 3327481 ctgaaactaa atcatccgga tccaaaaatt gaatatatct accttcagca tactttaaac 3327541 cataatttcg agcactgctc actccgccat tctgtttctt tgcatagaca atgttattgg 3327601 gatatttctg agcatattct ttacaaatga tttcactttt atcggggcta tcatcattca 3327661 ccagtattaa ctgaatattc tcaaaaccaa tagtttggtt aatgatactt tctatagctt 3327721 cagtgagata caactcaaca ttataaatcg gcattataac actgaaatca tagttaaaac 3327781 ttttttcgtt cataaaagat tactcctaac ataatgttta tatgaataag aattcgggta 3327841 aataaaatta agaaacaaga gagtactaat ttttgcaaaa caattttaat ttagtaaaat 3327901 gtatgaaaag cattccttac ctttttttaa aaacccttgt aagcaaactt ttaaaaatgt 3327961 tcacatggtt aagttctaaa gaatcatttg gtgtttttag tacaaagtca aatgcaaagg 3328021 cccaaatcgg tatttcgaca acaaaaccag catatctaaa atctcttaat ttatatcccc 3328081 atacttcaat tgtttttttc agttcttttc gtttgcattt ttttaatctt ttaaaatatt 3328141 ttatatatat tctgtcattt tctttcatct cataatactg gttaataaag tgccctgtta 3328201 attcaagtct aagccctttt atttttgccg aagtaacagt acatgaacta tgcagtactc 3328261 tttctttttt tatattttca agagcttctg tattttcttt taataagtga aacataaatt 3328321 ctttatagta catcggcata tcttgttctt ttataaattg cgggtcaata aattttaaaa 3328381 ctttaataaa atcatcaaca aaaactcttt gttcttgttg atctaaaaca gacttataaa 3328441 catctctata gttcggatat aaaaacagtt ttatatgata tacaattaaa aattgcaaat 3328501 aaggcaaaac tatatcatat ttgttgaatg aatccatcaa caaagtcatg taacattcat 3328561 tcaacaaata tgtgtacctt tttttgttaa accatgaacg atcaactaaa gaatcctgtt 3328621 ctttccgttt tctataaaaa tactttcctt ctgcaactgc tccgtatctt ttttctttca 3328681 gtaataactg gttaaaaaag atagcgtctt cccaaaactt tatagattca tcaaaaagga 3328741 cggtactagt tagtgtatgt cttctgtaaa aagtgccgcc aatataaaaa tgaatagctt 3328801 tataatcgtt gagaatattt ataactcttg ttcctttttc aaatctatta tttaatttat 3328861 gtcccccttc tttttcacct gtgtaataaa caggtaatac cgcaatattt acatgttcgg 3328921 aatcacaaaa aaaatcataa acactttgca gcgcattttg agagaatgca tcgtcagaat 3328981 caagaaaacc aataaattta gatctttcgc ttacatttga taatccacaa tttcttgcag 3329041 cagaaggtcc agagttttca attttcatga ttttaatatt attaggatat agatttttaa 3329101 aggattcaca aatttgagga ctgctgtcaa cactaccatc atctattaat atcagttcta 3329161 tattttcctt aaatccaatt gactggttaa ggacactctc tattgaatat cttaaataat 3329221 tttcagaatt atatattggt ataattatag aaaacatgtt tgtacctctt tatttagaag 3329281 ttaaaggatc gtttcaatta ctcttttaga agccttgcct cttctaaatt acaaaattta 3329341 ttataaaaat cctcatagtt atgatctata taaggattat gtaacaactc ttttaccgta 3329401 tctataagtt cttcacttgt ttgaagcaag tttcctggcg ttttttgctg aaaattaaag 3329461 taaaaacctc tgatacagtc tctataagcc gggagatcat acacaaaaaa tacaaggttt 3329521 ttttaaaaat tcatattatc aaaaaagaca gaagaataat ccataatcaa taaatcacta 3329581 attaaatata aatctcgaat atctttattt aaagaaacat cgttcacaaa atatttatat 3329641 ttccctaatt aaattgttct gaaactggat aataccattc ttacaagaat aaccatagag 3329701 tctccaaggt tccctcttca tttcctctaa tcaaattaaa gttaaattta tactggccag 3329761 ctttcttaaa attcattatc ccgcaaagtt ggtgcatata aaattatttt tctttaattc 3329821 cttatttgat aatgtagaat tggtagggga ttgtagctaa actgtttcca gaatagcttt 3329881 caaataaaat taatttattg tttcttggca gaaggacaaa aattttaaac aaaactgaat 3329941 aaactctaac tagtaaactt ctgcaattgg ttataataaa aatttcatca gtgaactcct 3330001 taaagagtga agattaatat ttacgcaaac aagaaaaaaa gaagcaactg aatttacttc 3330061 aagcctcttt tagttagtgc ttctataaac tagccatatc ttttctgatt tgggtagttg 3330121 aaatgcctgc tattcttgta aggtaaatgg cctcatagta ttcctttgta gacaatcgta 3330181 cgattaagta atcccaggtt cttttgctct ttccagtagc ttcatatgtc catagtgaaa 3330241 taaatcaaac attccgtacg tatcactttc ttcattagat aacatcacct tccaaccttt 3330301 tccaacttag aaaaaacaaa aatccttaac tgattgttta tcatttcgac atatttttta 3330361 cgttccatta ataataaaca ataatagcat atgttcctat aaaagttaag gctctttaaa 3330421 aatgtaaatc atcagcactt tttgacaata tcgttgcatt gatgtgtatt ttttacagat 3330481 ctgatatctt atctatactc attacaacaa gttttctatt ccggaagagt caattctttt 3330541 tgtcgcgttt tcaagtgtaa tgattttctt tctgctgcgt catttatttt gtacgccctc 3330601 ctcatattac ttcatcgtca aaacgtgaag gaattgtaat acgtagttcc taaaaatttt 3330661 cgtggtaaaa tttagtgaag tctttatcag gctaagggac tttatctaaa ctacgaatta 3330721 catatggaga tatatagatg aaaaggaggg ttgatatgat ataaacgaaa atcaattaga 3330781 taaaggaaaa actgaacact tctgaaaaaa gtgataagtt tctttcacta tatcctccaa 3330841 aaagaaccta aaggtcttgg acatgctgtc tggttcgcgc ctaactttat cggcgatgag 3330901 ccgtttgcgt ttctgcttgg agacgatatt gttcaggctg acacaccagg gttgcgccaa 3330961 ttaacggatg aatatgaaag aacactttct tctattatcg gtgttcagca agtgcctgaa 3331021 gatgaaacac actgttatgg catcatcgcc ccgctgacaa gtgaaggccg ccgttatcag 3331081 gtgaaaaact tcattgaaaa accgcctaaa gacacagcac cttctaatct tgccatctta 3331141 ggccgttacg tattcacgcc tgagattttc atgtatttag aggagcagca ggttggcgcc 3331201 ggcggagaaa ttcagcttac agacgccatt caaaaactga atgaaattca aagagtgttt 3331261 gcttacgatt ttgaaggcaa gcgttatgat gttggtgaaa agctcggctt catcacaaca 3331321 actcttgaat ttgcgatgca ggataaagag cttcgcgatc agctcgttcc atttatggaa 3331381 ggtttactaa acaaagaaga aatctaaaca aaaaggctat tggacattca tccaatagcc 3331441 tttttttatt tcaacatcaa agtcagtgta tgctcttcat tatcaactgc aaaaacctga 3331501 tcatctgtat tcacaagaaa acgcttcttg ctgctgtcat acaatacatc gctatcactt 3331561 aaggatagtg acgccgggtt gataggagaa atgttatgaa aaataagctc tgttgcttta 3331621 tcattctcca gtacataact gattttttca taatcaaaat tcagcgtttt tctgccgtca 3331681 gccttatttc cttcagtata accattcaat ttcgattgaa tgctggtgct gctgtctcct 3331741 aggaatttca gaaagtattc ataggaagat gctgcgtttt gcgagacata agacgtaaat 3331801 gcagtggcat gcaattcagc gtgtttcatg ttagttgcaa cagcgctctg tttcacataa 3331861 taagagtgcc cgtcaaactt tattttcgct gcttgtttgc cttttgcagc taccgttact 3331921 tttgtaccga atggcagtgt aacgtcagcc ttctgtttca aaccctgatc cttataagca 3331981 gccgcttttt catttgctat aaacccttgc ttattgattg cagttaagcg ttcctctgac 3332041 ttgccctttg catcgccatg atggttcttc acttcatttt gcggaatagc gccaaacgaa 3332101 gcaattgtac gaagcggggc attaaagaac atcgttcccg ccatgaagac agtcagaata 3332161 gacaaaatag caatttgaat ggcattggcc agtgatttcg gctttttctt ctttttgcgg 3332221 aaacgggcaa acgcttcagg atcttctttc ttcctctctt ctgtctgctc ttttttatat 3332281 gtctcttttt cttttttcga tagcttatta aaccagtcaa taaacgcttt gtactctttc 3332341 acaaccgttt ttgtttcatc aaacatacga agctcgccat agtgcatcca agcaacacgg 3332401 tcacacatct tttcaatctg accgattgag tggctgacaa agaaaatcgt ttttccttgc 3332461 tttttaaact catttattct gtctacacac ttctgataaa acgtttggtc ccccacagaa 3332521 agagcttcgt caataattaa aatgtcagga tcaatatgca cggagatcgc gaaaccgaga 3332581 cgcgacttca tcccgctgga atagttttta accggctgat taataaaatc gccaatctcg 3332641 gcaaattcaa cgatgctgtc atacatatca tcaatttctt tattggttaa ccccatcatc 3332701 aaacacttga gccggacatt gtcccggccc gttaattggt tattcaaacc ggcagcaatc 3332761 gcaatcagcg acggctggcc gttcatttca atttcaccgc tggtcggcgg aataatttta 3332821 gccagcaggt tagacatggt cgattttcct gacccgttta ttcctacaaa gccgattgtc 3332881 tccccttcat acacgtcaaa ggagacattc cgcacagcaa aaaaaccatt atccttagcc 3332941 ggaaaaaaca atcctttaat cttgtccgat tgttttttat acaaatgata ctgctttgaa 3333001 acatttcgaa acgaaacttt tagtttcatc gtaaaatctc cttacgtatt aaagaaagtc 3333061 aacaaacttg tctctgaatt tcatatgcag gatagaacct actaacaata aaaggaatgt 3333121 gaacaaccaa aagtacagcg tgtacttcat gtcatggaaa aaccatgctc catctaagaa 3333181 gctgttccgg aatccttcaa taatatagaa tagtggattc aacttcagaa caggcactaa 3333241 ttcggggtgg ctttgaccga gtttcgcatt aacatcccaa aaaattggca acaagaaaaa 3333301 caaaagtctt gttacggcct gcagcaaaaa ttgataatct ctaatcagca cactgatcgt 3333361 tgagttaaac aaactaaacg aaaacataaa agcaatcata cagatgaagt aataaatata 3333421 ttgtaaccaa tgcacactcg ggaacacacc attaactagg agtacaatga tataaatcac 3333481 catcatgatc atataactaa ataagttaga tgcaattgcc acggacggta gagaactaat 3333541 cgggaagttc attttagcca ccatattaat gcgcttaaat acactatttg atccatcaag 3333601 tatagttgga ctgatgaaaa accatgggat taatcctgcc agcatccaaa taataaaagg 3333661 cacttcgccc gctccggttg tcacaggacc gccctttcta atccccatac caaatacgaa 3333721 ccagtaggcc agcatttgga taagcggatt taagaactgc cataagacac ctaaataatt 3333781 catttgatat ttagacttgg tttcataagc cgccaatctt aaaattaaag gaaatgacgt 3333841 tatttgctct ctgagtatac gcaacaaatc attcattttt tatcttcctt agacttaatt 3333901 gtttttggga atctttctgt ttaaaatttg aaagcaccgc tgattattgt aacagatcct 3333961 gcattttttt tcacttctca acaagtatct aaaaagctgc cgaaaaatcg acagctatac 3334021 attttataaa ataacctaaa ttattcagct ttaaatacag tattaacaac cttttcagat 3334081 gaacgtcctg actctaaata gcaaaactta tcatagaaag gaccaaaaga aaccggaagc 3334141 ttataatcag gcgatgagat ctgcttgata gcctcaatcg tttcttcagt agtttttacc 3334201 aaaggaccag gagcttcttt ttcaaaatca aagtagaaac cacgcaactt gtcccggtag 3334261 gtttcgatgt cagggacaaa gaatagcatt ggccgtttta aatttgcaaa atcaaagaat 3334321 actgaagaat aatcagtaat cagcaaatca gaaaccatat acaattctcg aatatcctca 3334381 taagcagaaa aatcatatgc aaatccttca aaaggaccta aatcaaaatt ctcagctacc 3334441 agataatgca ttcttaagat tacaatatat tcatttccaa gttcttgtct aagttgatgc 3334501 aaatctaaat cgagatcgaa cttataacgc ccttttgcat agaactgatc atctctccat 3334561 gtaggggcat ataaaataac ctttttatca cgaggaatat ttaacctact ctttatcaat 3334621 gatattgttt cctcattatt atcattatga agaaaatcat ttctaggata tccagattca 3334681 atcattgtct tgttaaactg aaacgcccgt gtaaagatct cagttgaata accatttggg 3334741 gaaatcaagt aatcccaatt agaagcttcc ttgataaaat tccttttata ttttttggtg 3334801 tttgtaccag gcatatggac ttcttccata tccattgcaa gtctttttaa aggtgtgcca 3334861 tgccatgttt gtaaatatgt tgtatgacta ggtttcggaa tccataatgg aagccggctg 3334921 ttaacaaccc aatactcagc tcttgccata gcgaagagcc attttaatga gaggcgatta 3334981 atgtaaggaa ttcccttttc atcaaaaggc gctgaatatt gtttatttac actccaatac 3335041 attttatact cagggtggtt ttcccgcata tattcgtaaa tcgctctcgg attacaactg 3335101 tattgtttcc cattaaaact ttcaaaaatg actgttttcc ttttaactgg cattctgcta 3335161 gccatcatga atagagattt gtatgtttta gtgattaact tgtttctcat ttttgtgatc 3335221 ttttttattt ttgatactaa tctcttcttc tttcctttaa taaagtattt catccttgtt 3335281 ttcaggctat agtcgtttac tctgatacct agagtctgct ttttcttttt cttaaagact 3335341 tcataacgaa ctggtgcgtt gtttgtttta ataatactta ctaatccttt taatttgttt 3335401 tttcgatctc ctaaaacaag agcagtgctg ttgaactgaa tatccgttcc ttcatcgtca 3335461 ttgcatatat actccataaa aagacgataa acataacgtt tttcatttga gaaaggaatt 3335521 tctttcaaag gcactttcac ttcaaaatca tacagttccg gaacaaaacc atctgctctc 3335581 atgttttcca ggccatgtgt ttttctttct agcttgattg gaaatttttc ctcaataggt 3335641 gtttctccac ccttttttaa aataaggttc aagtttttta tccgatattg attttcggaa 3335701 ctcaggtacc ccgcataacc tgttatgctt atttcttcag agctaatctc gatttgatca 3335761 aatctgatga ttttggcctc tcttttcacc ttaatagaaa agttgccttt atcagttgta 3335821 taaggtaaaa tcaaaagttc tgtggtttga tcgacatgaa aggcgcgctc aattgaattt 3335881 acttcagcag aaagacgctt caagagtggt tcctgctccg catcttcata tttttttcga 3335941 aattcgacat aaaaatcata tgtttgtccc atttcaacag gcataggcaa aacatgagca 3336001 tttatctcag ttttatactc taatgagcca gtgttttgaa gcggaaattc agattccgtt 3336061 cctgaacgtc tctctttcag ctttaaaaat aactggtaat cctctaaaaa ttggtgttct 3336121 gaatcaattg agattaacaa ttcaagactt cctaaattgt ttttcaagct tttcaaaata 3336181 catttaatca cagtgttttc aatcattact tttttctgct cctctgtata aaagctcttt 3336241 cctttttgct tccttttatt agtgtcaact actaaggaca ttaactctct tttatttccg 3336301 tgaccctcca agagaaattg cctttaactg ttgtataggg ctctactcta tagccattat 3336361 tagtatctat actgtttcct gacaattttg tttcttcact cgaaagtctt cgcattgttt 3336421 taatatggcc atttgcattg aaaacaatat aaaaatcaat aacttgggtt ttattagcag 3336481 ctatcttttc aatatttaca tctttttcga gatcaattac aaacagttga tcattttgta 3336541 agtttgttga aataatttca gccttattct ttctgtccaa gcccactaaa cgtatttttt 3336601 taatatcatt atgatcaaaa ttctcaatgt caatttctat tttagtttta tcaaaatcct 3336661 cagtatagga actaatagaa ggatcttttt ttccaacctt tttagagaac ttctctcttt 3336721 ctattcgcac ctcaatcatc tgattaagag caaaagccca attttcaata tagttgggtc 3336781 ttgaatattt ttcagccatt ttaaaagctt gttctgaaaa tttttgatga gtactttcat 3336841 ctttcatcaa agagataata gcttgaccca atttctctat attatactgt tcaatgacat 3336901 atccatttgc tccgtcagta actaagctcc ttgctccgta atcataatcg tatgttacaa 3336961 ctggacatcc attgctcagt gcctccatat ttgatagacc gaacccttca aaatgagagg 3337021 ttgaaatggt tagccaagct ttttgaaact ctgagtcagg gttatccgta tagcctttca 3337081 aaaagacatt gttctgcagt ttggtatctt caatttcttt ttttattttt tcgaaatctt 3337141 cacccgatcc gaatatatca agttttgctt caggaatttc tttcacgact aaactaaatg 3337201 cttttactgc atgtatcaga tttttcatag atgcaagtct tgaaataatg acagctttgt 3337261 atttttcact cggcacattc aatacagcgg gatcaagagg cttatcaatt gtatgcggag 3337321 taaagaaaaa cgtctcttgt tcccctgaaa tcaatttaaa atcttctagc tgctcctcag 3337381 ttataaaaaa gacagcatcc aaattataca tctgactaaa tacttcttta tagcgaccct 3337441 taatttgata tttattgctg ccgtaatgct tgttatgaat aattgctcca taataggaag 3337501 aaggtgattt tttcacttta aagacatgtt tgtcttgcgg tctgctgtcc actaaaaaca 3337561 acttaggttt atcattttgt ttttgcagat attctatcca atattgacgc agttccgatt 3337621 catcttttac ttttatctca ccctcaaggg agtaccaaat aatatgagat aattgaacat 3337681 ctttttcttc attgttccat acatagagtt tgtctaaata tacttgattt tggtcattaa 3337741 tatattcctg cagatacatc ttgtttagct gcacatcata atgagtaacg agaactaagt 3337801 ttccgttctt cgtatattcc tctctcttta tgagctggtt tttatcattc caatagtcga 3337861 cgtaccggat agtttctcca tctccgtagt aaactacaga catttcattg ttcttcttac 3337921 caaacaatct caacagagtt tttgcaaatt tccccattcc aacttgcttt tttatctggt 3337981 caaggcctat cctttcttcg tatgatcttt tcccatttgt tctaacactt aaaaaatcat 3338041 cgaatagatt aataacactt gtgaattttt tatcaatctt accgttgctg tacaattcat 3338101 caatttttga agacaactct aaatcaaaac gaaacgttaa gaaaaaggtg ttttggttac 3338161 actcttctcc aaataatttt gaacgcaata ataatgattt cgtcagaccg ccataattac 3338221 ttggcagtcc accagagata aaataataat ccatgtcagg aatttgtttt atattagatt 3338281 cactcaccgc atgtaaagac aattttttac tccctttcgg catctagaat atatgatcat 3338341 tgaaatttat atctacccgg atactttagt cacaaaaatc aatgtaagca tcaaaaagta 3338401 cttcttattt caataagaag tactttaatt agatattgaa ccaatgatat caggatccta 3338461 aattataaac cagcaatttc ctctttgatc tttgttgtag agatgccttc tgttcttggg 3338521 aggtaaacaa cctcacactg atctttgaga aagtcaaatt taccttccca gtcatccccc 3338581 ataacaaaaa catcaatatt atgatcaata atatcttgct ttttttgctc ccaattcttt 3338641 tcaggaatta cttcgtccac atatcgaatg gtttctaaaa ttaatttacg gtgctcatag 3338701 ctgtgataag cttttttttg cttttgtaaa ttgaattcat ccgttgaaat agcaacaact 3338761 aaataatcac caagctgctt tgcacgctca agcaatttaa tgtgacccca atgcagtaaa 3338821 tcaaaagttc catatgtgat aacttttttc atttaaagaa acgctccttc ctaatgttaa 3338881 acactattaa aaacactact gacgttagcg attaaattct aaaaacctgt ttgtattcct 3338941 tatatcgaca tatttctcgt atgtcttcac tgatcattaa ttatagcata ccgcctaaaa 3339001 aaggttaagt actcatgagg agaaaaacat tccaaaatat gtaattacac tcagactcca 3339061 ttggcaccaa ggtctgttgt tcattcgttc attcaattgt aaaattggaa acatatttaa 3339121 atttaatgta aagataatgt taatcctttg ttgaagattt atgttaaaat ataaggtagc 3339181 ttgattttgc ttttagaaac tctcggtttt taactatata aatagaatct taaaggaagg 3339241 aggagccaga catgcaaaca gagactattc acaatattcc ttatgttaac agtaacttaa 3339301 catcatttat cgattaccta gagaaacatt atattgatca aaagattggt gctgtcattt 3339361 ccacagtcaa ccctgaaatt gcatttgcag ctattaaaga tcgggactac tttgatgtac 3339421 tatcttcttc aaacttcatt ttgcctgatg ggatcggtgt agtcatgatg tcacgtttga 3339481 ctaacaacag gcttcagtcc cgaatcgcag gttacgatgt ttttaaagaa cttctgggcg 3339541 ttgctaacaa aaagaaaaaa cgcatatttc tgtacggtgc gaagaaagat gttataaaag 3339601 gtgttgtatc caaaatttct tctgaatacc caaacattaa aatcgcaggt tattcagacg 3339661 gttatgttca agatcgcacc ctagtggcaa aacaaattgc aagagcaaat cctgacatgg 3339721 tattcgtagc tttagggtat cctcatcaag agaaattcat tcataactac agacacttgt 3339781 tccctaaagc cgtatctata ggtctaggag gaagctttga tgtatttagc ggtaatgtca 3339841 aacgggcccc ttcctggatg atacgtttaa atttagaatg gttctaccgg ttaatcttga 3339901 atccatggcg atggaaaaga atgcttagca tcccaaaata tgctttaacg gttttaaaag 3339961 aagaaaaaaa caaaaaaact ttctatccaa agcctgaaaa agatcataca aaacagattt 3340021 aaaaacaaaa ctttcaaata aatggatgat aaaaatgaaa ataagatcac tactggcgaa 3340081 ttgctatttg tattttttat cagcaatcgc cttttttctg caatgggtga aacctgaaag 3340141 caaagtgacc ctcctgatct cattcgaagc aaacgcaaaa gcgattcttg aggaatatga 3340201 acaaggacaa tactcttata aacttaacat cctgtatacc cagcaggcct ctgctattgc 3340261 cgagagcttc ccgaatgtag atgcatattt attacaagaa aaaaacccta tccatctcat 3340321 taaagctgta tacctaatgt ttaacagtaa agtgatcata acagataatt actttctatt 3340381 aacaagtgtg ttaaataagc ggaagcaaac gaaatgtatc caagtatggc acgcaaatgg 3340441 ctcactcaaa aaatttggtt tggaagacat tacaaacatg caacggacga aaactgatat 3340501 taaaaggttc caaaaagtat acagttcgta tgattattta actgttggct cagaagagat 3340561 ggcaaatatc ttcaagaaat catttggaat aaaggataac caattattaa aaataggtgt 3340621 acctttaaca gacccttatt accgagaaaa caagaaaaaa atttcagata ctctaaacat 3340681 acaaagaaaa aaaataatcc tctatgcacc gacgtttaga gattataata tgcaatcaat 3340741 tcaattgcct tttacagaag aacaattaat tcatcagtta aaagaagaat atgttttatt 3340801 tgttaagctg catcccgcca ttcagaacaa tattgatatt aaatattcca gtgattatat 3340861 taaagatgtt tctaactatg ccttgtttga tctactcatg gctgcagaca tattaatcac 3340921 tgactattct tctgttccct ttgaattttc gattttaaat aaacccattc ttttttatac 3340981 ttacgattta aaactttatc aacagaagcg gggattggtt gataattatc tttccataat 3341041 acctggaaga gcctgctatg acagtgaatc attaataaat gaaattcaaa ccccatttaa 3341101 ttattccaaa ataaaagttt tttccgatag atggaataag tattctgatg ggaattcaag 3341161 ccaaaattta ttgaatttca tcgaaaattt aataagctaa atgatgacac ttgttcaaaa 3341221 cagaacaagt gttctttttt ctattgaata ccgaacgtat gtttgcttta atgtaattag 3341281 ttgcttatgg cagcaaataa taatagaggt ggtaaattta tgagaaaaaa agaactgttt 3341341 gatttcacca acatcacgcc aaaattattt actgaactac gtgtagcaga caaaaccgta 3341401 cttcaatcat tcaatttcga tgagaaaaac caccaaattt atacaaccca agtcgcaagt 3341461 ggattaggaa aagacaacac ccaaagctat cgcataactc gtctatctct tgaaggttta 3341521 caattagaca gcatgctgtt gaaacatgga ggtcatggta caaatattgg aattgaaaac 3341581 cgtaatggca ccatttatat ttggtctcta tacgataaac caaacgaaac agataaaagt 3341641 gaattagttt gtttcccata taaagcaggc gcgactttag atgaaaattc taaagaactt 3341701 cagcgattct cgaatatgcc tttcgatcat agggttacac ctgctcttga tatgaagaat 3341761 agacagttgg caattagaca atacgataca aaaaataata ataataaaca gtgggtgaca 3341821 atctttaacc tggacgatgc aatagcaaat aaaaacaatc ctctttatac tattaacatt 3341881 cctgacgaac ttcattattt acaaggtttc tttttagatg acggttattt atattggtat 3341941 acaggagata caaacagcaa aagctatccg aatctcataa ctgtatttga ttccgataat 3342001 aaaatagtgc tgcaaaaaga aattactgtt ggcaaagact tgtccaccag atatgagaat 3342061 aacttccgtg aaccggaagg gatctgtatg tacaccaatc ctgaaactgg ggcaaaatca 3342121 ttaatggtgg gaattacaag tggaaaagaa ggaaatcgta taagcagaat ttatgcatac 3342181 cattcttatg aaaacttcat gaatcatgta cctatgcttc gatccccttt attaaaaacc 3342241 gtggggcacc aagatacacc tccagaaaga tttcaaccat ttattcaaac cttcatttta 3342301 gagtataatg ctcaaaacaa aaaatggatg gttccgactt caggttattt accatcttac 3342361 acatcaaatt tagtccgaaa tattactatc aatgcagatg gaaacttgca agtcacatta 3342421 aatgaacgct atattagttt actgcatcaa tcgatagaag gagatttccg cttaaaacaa 3342481 aaggatatcc gaatgggatc ctggtatttt gccggcggag aaaaatcaaa tgtgcttgaa 3342541 ataggtttta tgaaagggag tacaaaaatc agacccgatg atgcagccat ctcaaatgct 3342601 tcaagaatga gtatttttat gattgttgcg gacaagattg aggtgtgata atcaaatagg 3342661 ctgtagctat ttaatagcta cagcctattt gcaactttct aagtttttta tcgatattcc 3342721 ggaacatcaa aataaagtgt ataaccgtcc agcaatgaat acaggctgta catgcggttt 3342781 acttgtttgt acgcccagcc gatgtctgtt gcgtattgat gtgtcgctgt agctgaccat 3342841 ctcattttgt acagtgtgtc ttgattgtaa gctgtgttgt ggatatacga tgagcctatg 3342901 aatttagctc cgccgataat ggccgcttct ggtgtgaacc agccctgctc gtacgcatat 3342961 ttggctccgt agtaattcgg attgctgtcg tatgctccaa ttccatacat gttgtatacg 3343021 gtttttccgt tataggttaa tccattggct aaagcggatg tcccgtttcc tgtttccaga 3343081 agagcgtgtg agattaaata cagttcgttg atgctatatt gattggcggc atcgataaat 3343141 gcctttgctc tccctgtcag gatgccttta cccgcaagca ctttctgatt tacctcagta 3343201 acgctgagac ccgctgtctg tgacagcttg agaaattgga agtagtattt gctgtctctg 3343261 gaaaagttat tcggatccac gtattgaact acttcatcac tgcttgcgtt tcgccagccc 3343321 aaattgatct tagcccagcc gtttatctgt ccgatgactt tcactttatc gcctttttta 3343381 aactggccga tcacgtttgt cgggctgact tccggcgttg accggatatt tagtacatca 3343441 gccgtaacag ttgatgttgc tgtattaatg tacgtgagcg atacgtaagc cgctccgtct 3343501 gtttgcggac ttactgtcat ttgtttttgg accatatcac gaagcgagag attgtagttt 3343561 gttttcatga tttgcgggcc gtttttgatc ttcacgatag atgatgtcca tccgtataat 3343621 tgttttagct tcgttgatgc cgcagcagct gtatcattgc ctgtgaactg ctcatttacg 3343681 ctgattttat aaagcgtatt gcttttcgtt gtatagctcg gggttacact tttcgattta 3343741 agataggtta acccattgtt caatgcggtt ttgctgctaa gctgtgttgt cacgattttg 3343801 tattgtgtat atgcagtctg gcctgttttt gatgttgtga ctgcgatatg attttgtttg 3343861 aaaaatgtta aaacgcggtc aatctcttct tggctgatga tagcttcagt tgtgatttga 3343921 tagctgctcg cagctgtctg accggttttc tggcttgcta ctgatatatg attcgatttg 3343981 aaaaacgtga gtgcctgatt gactttcgtt tgatcaagca gagattcggt tgtgatttta 3344041 aacgtgtcag ctatttgttt tttgacggat ttcgcagaag cacttagctg atttttcttt 3344101 aatatgttca aaccctttgt gacttttgct tgatctgatg tttcttctga gatgagctga 3344161 tattgatttt ctgctgttga tccagctgct gtttttgcag cttttacttt tttctgagca 3344221 aagaaggctg ctgctttgtt tgcttgctgc tcgcctaaaa tctttgccgt cgtgatttga 3344281 taagctgcag acgttgtcgt ttttttgacg ctggatgacg tgtaatgcca ttttttcttt 3344341 ttaaagaaag tgtctatttt ttggagctgc tgttttgtta tacccttcat attcacggta 3344401 tatgatgtgc tttttccaac ctgttgataa ctgccggata cgccagtgtt tttcttgatt 3344461 tggctgatgg cgtcctttac tgtactcagc cctttgaaat aagctgattg gacattgtat 3344521 gactcaacgg ttgttttttg attgatggac ttgtagctgc ctgtgatgcc agtgctctgt 3344581 ttcagctgct gcaatagagt tttggcattg gcttcacctg aaatggcggc agttgtgaac 3344641 gtataatagg cttgcccttt cactgtttcc tttaatgatg cctgcagccc agattccttt 3344701 tggaaggcgt ttttgatctg cgctgctctg ctgtctccca cgattgtgcc agactgaatg 3344761 gttgtgacag acaccgtgtg tgtgatgggc tgatacgagc ttttaatccc cgtttgcttg 3344821 gccaggctct ggataagcgc cttgactttt gtctcatcag caatgtctga tgtcatgacg 3344881 ttcatatagg gctgagctgc tccgtaagct tttacagcgc cagccactcc cgtctcctgt 3344941 ttcagctttg ctaggatagt gttggcctgt ttttctccgg agatggcacc tgacgagatg 3345001 gtgacatatg gctgtttgct tccaacagga cttgacgttc ctgtaattga tgtctgtttg 3345061 gcgagtccgc tcagtattgc tttcgcttct gattcgctat gaatgcctga ggcggaaatt 3345121 tggtaggtcg ttgttgtgcc tgaagcctga taggatgcat cccagccagt atctttttcc 3345181 agtttggcga cagcttgtga ggcttggctt tctgtactga acgtattcga cggctctact 3345241 ttatatagtg agtagtcggt atacgcggct gcctgggcag aaccagacat ggcaaaaaag 3345301 gcaagggacg cggcggatag aagcataggt gcgattagtc tctttttcat tccttctcct 3345361 ctttcttatt ctatgagtat ataaaactag tttatttatc ggcacgcgca tgcttcattt 3345421 ataggtgaat cacttccatt ttctaataaa aaaacttaac ctcgaagtga gattaagttt 3345481 aaatatgaga cacgataagg gtacaagttc cttttatcgt aaaatcgggc atttgagccg 3345541 gcaaaataaa gtgatcacct tttttgagcg gacatgtttt gtcctcatac ttgagcaaac 3345601 cgcttccttc tatcacgctg caaatcagaa aggattcatc ctgagccatt tcagcttcgc 3345661 cattgatgtc ccatttataa accgaaaaat attccccttg gacaaatgtt ttaatggtta 3345721 ttccttttct tgattctgtc gattcatcta tatacccgtc cacatgggga accgtggcgg 3345781 cattgaccgc tttggcaaaa tgaagctctc tcggacttcc gttgctatca agacggtcat 3345841 aatcgtacac ccggtatgtg gcatctgaat tttgctgagt ctctaaaaca agggccccct 3345901 tgcacaatgc gtgcagcgtt ccgctcggca cataatagaa atcacccggt ttaattttga 3345961 ttcttcgcag caggccctcc cagtcaccgc tgttgatcat tgtgacaagt tcggtttttg 3346021 agcgggccgt atgcccgtaa atgatttctg cgttttcctt acagtcgata atgtaccagc 3346081 attccgtctt gccgagttct ccctcttcgt tttctccggc atagtaatca tcagggtgaa 3346141 ctttaattga cgtatcttcc ttcacatcca gcagctttgt cagaagcgga aaccgatccc 3346201 cctctacgcc gccgaatact tcacggtgct cttcccaaag ctcgatcaat gtctttcctt 3346261 tatacgggcc atttgcaaca gtgctcggtc cttttggatg agcggaaatg gcccagcatt 3346321 cccccgttga ttctgaagga atactgtatc caaatctatc tcgtaaagcg gttccgcccc 3346381 agattttttc tttaaacaca ggcgttagaa aaatcggtga ttgcgtcatg atccgtaccc 3346441 ctcccctgta aataactgat catcattttc ccggtgcgcc cctcttacaa acgcccgtat 3346501 aagctgcctt tttcctatga caacatatgt acaaagcatc atcttttcat taccccttca 3346561 aagaaaacgc ttcctatcta ttatatcacg tcgaaaagaa gctttgtttc agccttttcc 3346621 tcgataagaa taattctcct tttttgatac aaattaataa aaaccgtcaa tatgtttaag 3346681 aaggagagaa actatgcaaa tcgactctga tctccagaac aatttagaca cactgaaaaa 3346741 aacattggga caaaacgacg atatgatgtt ttatacattt gctttcggag atagcagaca 3346801 aaaggcgtgt ttactgtata ttgacggtct gacagagaat aaaatgctgg cgcaatacgt 3346861 catttctcct ttacaaaaag aggcgttggc ccataaggaa tgctcgattg aagacttatc 3346921 cgcctttttt ttcggctttc accacagcgt tgtttctaca atgaaagaaa tagagcagct 3346981 cgttttttca gggcaagcca ttttgctcgc tgatggctat cgcggaggat tagctttcga 3347041 cacaaagtca gtcgcaacac gcagtcttga tgaaccctcc tccgaagtcg tggaacgcgg 3347101 ccctaaaata ggatttattg aaaagctgcg gacaaacacg gcgcttttgc gtgaacggac 3347161 gagtgatcct aatctcgtca tcaaagaaat gacactcgga aaaaggacca aaaagaaaat 3347221 cgctgtcgct tatattcagg atatcgcccc agattatgtc gtcaaagaag tgtttaaaag 3347281 gctgaaatca gtcaatatag ataatttgcc ggaatcgggg acgcttgaac agctgattga 3347341 agacgaacca ttttcaattt tccccacaat attaagcaca gaacgaccgg accgggtcga 3347401 aagttctcta ttagaagggc gagtgtccat attagtggat ggtacgccgt ttgctttgat 3347461 tgtaccggct acggttgacg aatttattca ttcgcccgat gattacagcc agcgctggat 3347521 cccaatgtca cttgtacgcc ttcttcgtta ttccagcatc ctgatcacca tttatttgcc 3347581 cggtctgtat atttctctcg tttcttttca caccgggcta ttgccgacta gaatggccat 3347641 ttccattgca ggcagcaggc ttaacgtacc attcccgcct tttgtagagg cctttatcat 3347701 gatctttacg atcgaattga ttcgagaagc cggattaagg ctgcctaagc cgattggaca 3347761 gacaattggc cttatcggcg gcgttgtcat cggacaggca gctgttcagg cgcaaattgt 3347821 cagtgcgctt atggtcattg tcgtttctgt cacagcactg gcatccttta ccgttccttc 3347881 atacgcctat aactttccgc tgcggatcat tcggatcggg gttatgataa gtgcaacagc 3347941 gcttggcatg tacggcgtta taatggttta tctgtttgtg atcggccatc tcatgcgcct 3348001 gaaaagcttt ggccaggatt acattatccc gatcatggcg cagcctggac aggatttgaa 3348061 agacacagtc atccgtattc ccacgatgtt tttaaaaaga agaccgacac gaaacgatcc 3348121 cgaagataac atcagacaaa ggtgatggct atgaggaaat cagagcataa actgacattt 3348181 atgcagacgc tcattatgat cagcagcaca ttgattggtg ccggggtgct gacccttccc 3348241 cgctcagccg ccgaaaccgg cagtccgagc ggatggctaa tgatactgct ccagggcgtt 3348301 atttttatta tcatcgttct gctttttttg ccttttcttc aaaaaaacag cggaaaaact 3348361 ctttttaagc tcaacagcat tgtagctgga aaattcatcg gctttctatt gaatttatat 3348421 atctgtctat atttcattgg gattgtttgc tttcaagctc ggattttggg agaggttgtc 3348481 ggattctttt tgttgaaaaa tacgccaatg gcagttgtgg tgtttatatt tcttgcagtt 3348541 gccatctatc atgtaggcgg aggcgtttat tcaattgcaa aagtatacgc ttatattttt 3348601 cctataaccc ttattatttt tatgatgctt ctgatgttca gctttcgctt gttccagctt 3348661 gattttatcc ggccggtatt tgaaggaggc tatcaaagct ttttctcttt attcccaaaa 3348721 acattattat atttctccgg atttgaaatc attttttacc tggtcccctt tatgagagat 3348781 ccaaagcaag tgaaaaaggc tgttgctctg ggcatcgcga cttccacatt gttctacagc 3348841 attactttgc tcattgtgat tggctgtatg actgtggctg aggcaaaaac ggtgacatgg 3348901 ccgaccattt cccttattca cgcattagag gttccgggta tttttattga acgatttgat 3348961 ttgttcttac agctgacctg gacagcccag caatttgcct gtatgctcgg atcctttaaa 3349021 ggcgcccata tcgggttaac ggaaatcttt catctaaaaa ataaaaacaa tgcatggctg 3349081 ctgactgcaa tgctggctgc gacgtttttc ataacgatgt atcccaagga cttgaatgac 3349141 gtgttttatt acgggacgct tcttggatat gctttcttaa ttgtgattac aattccattc 3349201 ttcgtctggt ttttaagctg gatacagaaa aaaataggga gggggcagct gcaatgaaaa 3349261 cagcatcaaa attctccgtc atgtttttta tgctgctggc cctctgcggc tgctgggatg 3349321 tcaaagatat cgagcaacta tccttcgcca gagggctggc gatcgatgag acaaatgatc 3349381 accagtacaa actgacgtat caaaatcttc ttccccaaag cgaagacagc caagcatccg 3349441 gaaaacccga atttgttaat gtaacgtccc acgggaaaac gattctggaa gcagtcagtg 3349501 atgtatccat caaggaccct cctgtttata gcgatcattt aaaagtgatc cttctgggag 3349561 aaaaactgat gaggaatcaa aatgtagacc aagtcctcaa ccactttatc cgggatgatg 3349621 agctgcggcg aagcagctat ttgatggcag ccagagggaa tgcagctgat gttttcacaa 3349681 aaggaaaccc caatcagcag cagccgatgc cctccgaaaa actgattgat ttgacaactc 3349741 acagcggata taacggtaag attatgatac cgctgcgcat cggaagagct tctgtctact 3349801 ctcagaacgg gtacagttat cttattcaag ccgtgaaaaa cgaaaaggga aaagccaagt 3349861 atgacggagc aggcattatc aaaaggggca gcaataaact cgttgggttt ctttcagctg 3349921 atgaaaccca aacactgtca tgggtcatgg ggacgatcca aggcggtgtc atgccgacga 3349981 cagataaagg acatccgatt acgtttgaaa ttaaaaagtc gaaaacgaaa attaagcccg 3350041 tcattgaaaa cggaaagcct gtctttcata tttctgttaa aacgaagggc atcctgacag 3350101 aagaccaaaa cccgaatgaa aactccttta gcaaaagtta tttgcacagg ctggaaaaca 3350161 tttttgaaaa aaagcttgaa cgagatgtaa agcaggtgat ggataaactg cagcacgagt 3350221 ataaaaccga tccggtcttt ttatcagacc acataaggat tcaacaccct gactactgga 3350281 ataaagtaaa agggcattgg gatgaaatat tttctgagac tgattttaag tacgatattt 3350341 cttttaaaat cattaacttt ggcacggtgg gaaagtaagc aatcaaaagg gtgcgcatga 3350401 tcgcgcaccc ttttttatgt tccgacagtc tgctgttttc cggccgctcc tccctgtccg 3350461 tttttgtccc gtaaatcctg ctcaatttct tcaaggcttc ttccctttgt ctctgtcact 3350521 ttaaatcgga caaataagaa cgccatgata ccgatcgcgg cataaatcag gaataaataa 3350581 ctgattccga tcgcttccat taatattgga taggttaatg aaacaatcag tgtcccaacg 3350641 tgcaacatta aggtcgaaac accggtcccg attcctctga cgtgaagcgg gaacaattca 3350701 ggaagcatca cccacacaac cggtccccag ctgaccgcaa agacaacgat aaacacgcct 3350761 aaacaaatga cggtcgtcca tgaggcagcc ggagtgttat cgaaaaagag atttactaaa 3350821 gcgagaacga tcaagctgat caccatgccc gcattcccga atagcagtaa cggctttctt 3350881 ccaatcttgt cgatgatttt aatcgctact aatgtcatga gaacattgac tgtgccgatt 3350941 ccgaccgtgc ctaaaatcga agcggagttt ccgaatccga cgtttgtaaa ggtctttggc 3351001 gcatagtaga tgatcgtatt cgttccgata aattgctgca aaaaagcgag tcccaaacct 3351061 gcaataagcg ctgggcgcac ccatggatcg aacagctcct tcagaccgcc ttcatcctgc 3351121 ttttccgctt cttttatatc atgtatttcc tgatcaatat cttttgtgcc acgcaatttt 3351181 tcaagaattt tcttcgcttt gctttcttcg ccattcgtga acagccagcg cgggctctcc 3351241 ggcataaaca aaatgccaat aagcaagagc aatgacggca cagcagccaa tccaagcatc 3351301 cagcgccacg cttcggcatc ggcaaatatg taattgacaa tgtaagaaag aaggatgccg 3351361 accgtgatca tcagctgatt cagtgatgac agcgccccgc gtttatgttt tggcgccagt 3351421 tcagataaat aaaggggtac gattgtcgtc gatgttccga ctgcaagtcc caaaatgatg 3351481 cgaaacagca ccatgactcc tgtatttggg gccagtgcca caccaagacc gcctatacaa 3351541 aacagcagcg cggctgccat aattgctttt tttcttccga aacggtcagt cagcttgccg 3351601 gccgctcctg agcccaatat cgccccaacc agcaaggagc tgacaacaag accttctgta 3351661 aacgcgttta agcctaactc ctttttcata aataaaatag ctccggaaat cactccggta 3351721 tcatagccat ataacgcgcc tccaagagct ccgaaaaaat aaagccatat atttgactgc 3351781 tttttcataa agatgactcc ctttctccat cagctgcaat gacattgtct gtgggatttt 3351841 tttagaaatc ttttagcctc tttttccggc cattaaacct ttttattttt ctgatcataa 3351901 gttttccaat catttacttg tatttttttc aatgtcgccg aaacatttta cctgctgcgg 3351961 cgtccaatat aaggtgattc agtacattat cgttatcaat tttcaaaaac aagaacttat 3352021 aaatatagga atatttatcg aaaaatgtct ttcgagtagt tgccccatgg caaatagaat 3352081 ggtacgcttc aaatattaaa gaaacgtgag gtattgatat atggaagaac gatcacagcg 3352141 cagaaagaaa aaaagaaaac taaaaaaatg ggtgaaagtt gttgccggat taatggcttt 3352201 tttagtcatt gcggcaggct ctgtcggcgc ctatgctttt gtaaagctga acaatgcttc 3352261 taaggaagct catgtcagcc ttgcacgcgg agaacaatct gtaaaacgga tcaaagaatt 3352321 tgatcctgga aaagattctt tttctgtatt gctcttagga attgatgcca gggagaaaaa 3352381 cggcgagacc gtcgatcagg caagaagtga cgcgaatgtg ctggttacat ttaatcggaa 3352441 agaaaaaaca gctaaaatgc tgagcattcc gcgtgacgcc tatgtaaaca tcccaggcca 3352501 cgggtatgat aaattcacac atgctcacgc ttacggcggc gttgacttaa ctgtgaaaac 3352561 agttgaagaa atgctggata ttccagtcga ttatgtcgta gaaagcaatt tcacggcttt 3352621 tgaagacgtc gtaaacgagt taaatggcgt caaagtaact gtaaaaagcg ataaagtcat 3352681 tcagcaaatc aaaaaagata caaaaggtaa agtcgttctt caaaaaggaa cacatacgct 3352741 tgatggggaa gaagcgctcg cttacgtaag aacacgtaaa gcggacagtg accttttacg 3352801 cgggcaaaga caaatggaag tgctgagcgc cattatagat aaatcaaaat cattgagctc 3352861 aattccggct tatgatgata ttgtggatac gatggggcaa aatttaaaaa tgaacttatc 3352921 tcttaaagat gccatcggcc tgttcccgtt catcacttca ttgaaatcag ttgagtctat 3352981 tcagctgacg ggttatgatt atgaacctgc cggagtctat tatttcaaat tgaatcagca 3353041 aaagctgcag gaagttaaaa aagagctgca aaacgattta ggtgtataat gaacgggatg 3353101 gcgattacgc catcccgttt tacatatttc cttgttgaaa attatcaaag taacgtttag 3353161 ccttaattta tatggattat gtttcacagg caagctgaac atactacacg aagcagcttc 3353221 atttttaagg aggttcccct acatatgaaa tgtattgcga ttgatctaga cggaacatta 3353281 ctgaataaag aaagcgtcat ttctgcggaa aacagagagg cgatcaagcg ggccgttgat 3353341 gccggcatcc tcgtcaccat ttgcacggga agagcgacat ttgatgtaaa agcgctgctg 3353401 gatgacttgg acatccctat cattgcagct aatggcggta cgatccacga cacgggttac 3353461 cgtttgatca gccggacatt aatggatcag gaagccggta aagcgattgc tgattactta 3353521 ctttcaaaaa acatttactt tgaggtatat acagatgacc atctgctttc tccttttgac 3353581 ggcgaagcta agctgcacgc ggagcttgac attctaaaga gcgcaaaccc aaacgagcag 3353641 acggatgact tgtggcaagg agccatgact caattcaaac agtttggcat taaaccaatc 3353701 cctcatatcg aatcggtttt tgacggcggt gaaaacattt ataagcttct ttgcttctcc 3353761 tttgatatgg acaagctgaa acaagcgaag gaagaactga agcatcataa aaaactggcg 3353821 caaacctctt caggaaaaca tattatcgaa atcctgccgg cctcgtcagg aaaaggacgc 3353881 gcgttaacaa agctggctga catatacgga attgaaacac aggatatcta tgcgatcggc 3353941 gatagtccaa acgatttgtc catgtttgaa gtcgccggac accgtatcgc catggaaaat 3354001 gcgattgatg aattaaaaga aaaaagcacc tttgtcacaa aaagcaatga cgaaaatggt 3354061 gtggcctact ttatagacca gcttctttcg gggcaatatg cataaagaaa agactccaga 3354121 gattggagtc tttttctttt attgcacccg tatacttcct gcgtatttat ccttccaata 3354181 tgtgctcgtg ttcatattgg taatggtcac gccgtttgat aatgtgacat gaacaacttg 3354241 tccgtttccg atatagatgg agggatttaa gcttgttgat tgaaagaaca caatgtctcc 3354301 cggcttcagg tccgccttct caatcttagt tccggcattg tactggcttg ttgcgtatcg 3354361 aggcagggaa ataccggctg ctttctggta tacatattgg acaaatccag ctgtatcaaa 3354421 tcccgtctca ggtgttactc cgccctgttt gtaaggcact tctccgacat aaagcgtcgc 3354481 ttcggaaaca atcggatttt ctttcgggat tgtcaggttg tcaaatcggc gaatacccgt 3354541 catcttcgat ttccagtaat cctctgacaa ataggaaatg gttacttttt ctgaccggct 3354601 tgcctgaatg aacctgcctg cgcccgcata aatgcctgca tgtgaaattc ccgttttata 3354661 cgtattgctg aaatagacga catcaccagg ctttatgttc tgaggggcta ccttctcgcc 3354721 cactgcccac tgctgttcgg ctgatcgcgg tagataaatg ccgagtgcct gttgaaacac 3354781 atattgcaca agccccgagc aatcaaagcc ctctgacggc gtgcttccgc caaacacata 3354841 tgggacaccg atatattttt cggcctcctg aacgacagga acatcagccg ttgccggatc 3354901 ggcagcgatt cgtctcgccc cgatataagt tccgctccaa tagctgcttt ttttgtaatt 3354961 ggtgatgata accccttttg actgtgtact gtgaaccatt tggccgtctc cgatataaag 3355021 ggcgtcatgt gtcggaacag tgccggtgct tccctctttc ttgaaaaaca aaatatcacc 3355081 cggcttcagg ttttccggtt ttacagctgt tccgatttta tactggtcgt ttacagatct 3355141 cggcagatga atatcagcct tactgaacac atattgtatc aatcctgatg gatcgaaacc 3355201 ctctttcggc gtttccccgc catatttata ctgatatcca agcaggtttt ttgcttcgct 3355261 gacaatcaat tctgatgatg tatcagcttc cgcaatctcc gcttttgtca taattggaac 3355321 caaaaaacaa atgataaccg ccacaagcaa aaacttcttc cagtttgcca gtgtgttcac 3355381 ttttattatc tcctcctctt tttgcagttt taacatcggt atttttttga atatgttaag 3355441 agacttttta atatttttac agaatgaata tgctgggcaa ataaaaagag agtgtctcat 3355501 cagacactct cttttttgaa ttatttattg gcgtttaccg gttcttcctg ctgctggatt 3355561 ttattcattt ccatatcaat cttctgtttt tcctgatctg tcagctgatc attgaattta 3355621 aaagctgaca taaacatgaa cacgatggct acggcaacaa acggccagat ggctttgaca 3355681 aatttcatct ttatcactcc gattatttag attttagttt gtcactatga tcaatatcaa 3355741 acgtcagttt tccgtcttct actttccaag cgaaattaga gtctttcgtc agttcgcgaa 3355801 taatggtttt ctgtttaagg ctgtcttttt tcacaggcgc aggtgtcgct tcatggatat 3355861 cgatcggtgt cacttcaaag cgtcctgttc catttttctt caggtgatac tgaaccagtg 3355921 cactgtctct tgttctcgtc cagccttggt caaagacaaa gttgccgagg ctgtagaaaa 3355981 tgacggttcc gttatatact tcaatcggtt ctaagacgtg cgggtgatgg ccgacgatga 3356041 tgtcagctcc cgcatcagac atggctcttg caagctggcg ctggcggtca tttggatcat 3356101 tgtcatactc ttgtccccag tgtgactgca caacaacaat gtccgcatgt tttttcgctt 3356161 ctgaaatcat agggatgaag atttcaggat ctgcgggcag cacgcccggc gtattctttt 3356221 tagccgcgaa acctttcccg gacacatcgg taaagccaag cgtcgcaatc gttaccccgt 3356281 tgactttctg gtacgaaatt ttctttttcg catcacttaa gctgtatccc gctccaacga 3356341 tatcaagatt ttgcttcgca aattctccaa gcgtatcttt catgccctga acgccgtaat 3356401 ccattgcgtg gttgttggcg ctgttgagaa ccgtgaaatt catatccttc aagactttca 3356461 ctgattcctt attcgtctgc agatgaatct ctttatctgc ttgtttataa ttcttttgat 3356521 aggttaccgg gttttcaaag tttcctgcta cataatccga ggctctaaag atcggttcaa 3356581 catattgaaa aatactgtct gccccttttt gctccgttac tttttcaaca tagcgtccca 3356641 tcataatatc gcctacaaat gaggctgaga gtacgtcgtc agaatacgtt ttgaccttcg 3356701 gcgtttccgc ttttcccgcc cacatgaaag cgaacataag gacaaaaacg atcggaatgg 3356761 caataaatac gtgcttattg gttttctttt tttgctgttt tgtcagcttt agcagctttt 3356821 catgaaagct cagttctttt ttcatcgttt gacacacctt acattaaatt aagtagtaaa 3356881 caaacatgat agcaaaggtc gctccgctca atagcagcgt gcttccgaac gtaatggtta 3356941 aaccttgttt ctgaatggta ttggcaatta aacctggcac gatgatgccg attcctcgaa 3357001 attctgcgat ttcaaatggt acaatcgggt atagaaaatc aaacgcgatt tttaggacga 3357061 tccctgttat cagcatggca gcgaattttc tgcgtccgta caaaatcata aatttggata 3357121 aaccgtattt cacaatgaca tacgtgagca agctcactag caaaacaagt aaaataaaga 3357181 ccggctgatt aaacacaagt cctaaatatc ccggtacaac aagtcctgcc ggcacgatcc 3357241 ctgttttttc cgcaaaaatt aaactgagta gtacacctaa aattagtgcg atgtataaat 3357301 ctgatccgaa catgtctgca tttcccccta gcttacgagc tgctttacct tgtattcgtg 3357361 gattttttca attaaaggct ctgcggcacc atgaatattg ccgacgccat atatgacacg 3357421 gttgtgcatt cttttcttta acaattccat aatttcatct gttgacttat actctagatc 3357481 atgcagtttg tctgcaggaa ttttgccttc ttcgtaggct tttacgatcg gttctgttgt 3357541 ttcaccgatt aagatcagtt cacttgcttc aatataaggc aatacgtcat ttgcgaattg 3357601 ctgtgtccga tcgacacggt ctgcgcggca gttcatgatg atgatcggat catcggtcgg 3357661 gtaaccgatt tcttttacac gtttccatat attcaaagta gaagaagcgt cgtttgcggc 3357721 aaacccatta acaaagtgcc caggctcgct cggactgatc agcggaagaa ttctcattgc 3357781 tcccggatct ggcggcgcat tcagcattcc cttaaatgct gtttcttcgt caatgccgag 3357841 tgcttgagcc acacccagcg ccagagaagc gttatcaggg aataccatgt attcaaattt 3357901 acgtaaatac tcatctgtaa tttttgagtt atcagcaatg atgacttttg tgtttcgttc 3357961 ttttgctttt tgtttaaaga actcggtata ttcactatct gtaatgacaa gatggccatt 3358021 ataaggaatt gtagcagtaa acgcttctgc aatttcatca agcgtcggcc ccatgacatc 3358081 catatggtct tccaaaacat tcacaatgac gccgatattg gcctgcagaa gttcttcctg 3358141 aaagatgatt tgataatctg ggttaacagc catgcattca ctgacaatcg cgttagcccc 3358201 tctttctact gtttctctca tgacttcttt ttgctctccg atattcggcc cctgaggttt 3358261 ccgtttaatc ggcttttcct ccggtgtgtc ccagtaaatc attcttgcat ctgttcctgt 3358321 tgtttttcca acagtcttgt aaccggcttc tattaatatt ccggttgtca gccttgtcac 3358381 agtcgatttt ccgcggatgc cgttaatatt cacccgaaca gggagggcat caatgttttt 3358441 ctgatgtcgt cgtttttcta atattccgat gaccagtatg acagcacagg ctataatgag 3358501 taaccacatt gcttttcgac atctccttct atattgttgt aaattcattc atcagtatat 3358561 agaatcacta tgaattctca atcggcatta tgtaacataa tcttccctaa tcgactaagc 3358621 caaacttctc ttttgaaaga gattttatac ctacaaactg ttttctattt ttggaaaaca 3358681 gcaggactta taccttatca ctttttaaaa aaatcaaaga gaatgcgctt tcatttttct 3358741 cctgatatcc ttctggacgt atagtcacac cctgctgttt gtatttaata tgcatttcaa 3358801 atcaatcttt ttttcagcct ttgttatcaa gcatttcctg ctatcatgcg tgtttccggt 3358861 tcttatgaac acaaaataat tttatcctgt ttcttaagga caaggtcata atgtcatcct 3358921 ttctgcatgg aataagcaat atgaggccca ttccaaaatg actaaggagg ttcgagatga 3358981 aaacgctaaa catacgagtc cgaattctct aacataatta aacattttct gggatgatag 3359041 tcttttctgt ttctccccat ttacaggtct aaacgcatga ctttgaaaca attttaataa 3359101 aacttaatat ttgttcaaga aatcttcatc catatttgtg aagactttgt caaaaaaaga 3359161 gtgaaaacct taaatttttc aattatatat acaatttaca attagatttc ttttgatatt 3359221 tttattgcta acttcggatt gttcatgata atctatctat gtaaacggtt acataaacaa 3359281 ggaggagctg ttttggctac aattaaagat gtcgccggag cggcgggcgt ttcagttgcg 3359341 acggtttccc gcaacctgaa tgataacggc tatgtacacg aagaaacgcg aacgcgtgtc 3359401 atagcggcga tggcgaagct gaactattac ccgaatgaag tcgccagatc tctatataaa 3359461 agagaatccc gactgatcgg acttttgctc ccggatatca caaacccttt cttcccccag 3359521 cttgcccgcg gtgcggagga tgaattgaac cgggaaggct atcgccttat tttcggcaac 3359581 agtgacgagg aattgaaaaa agaacttgaa taccttcaaa cctttaagca aaatcatgtc 3359641 gcaggcatta ttgccgcaac gaattacccg gatctcgagg aatacagcgg catgaattat 3359701 ccagttgttt ttctggacag aacgcttgaa ggggctcctt ctgtgtccag tgacggctat 3359761 acaggagtaa agttagccgc ccaggctatc attcacggaa aaagccagcg cattacgctc 3359821 ttgagaggac ccgctcacct gccgaccgct caagaccgat ttaacggcgc tttggaaatc 3359881 ttaaagcagg ctgaagttga ttttcaggtc attgagacag cttcattttc aattaaagat 3359941 gcacaatcga tggcgaagga gctgtttgcc tcttatccag cgacagatgg tgtgatcgcg 3360001 agtaatgata ttcaagccgc tgccgtttta catgaagcat tgcggcgcgg aaaaaacgtg 3360061 ccggaggaca ttcaaattat cggctatgat gacattccgc aaagcggact tctgttcccg 3360121 ccactttcta caattaaaca gcccgcatat gatatgggga aagaagctgc caaactgctt 3360181 ttgggtatca ttaaaaaaca gccgctggca gaaacggcaa ttcaaatgcc tgtcacctat 3360241 ataggaagaa agacgacaag aaaggaagat taagatgcgt aatatttgtg tgattggtag 3360301 ctgttctatg gatttagtgg tcacctcgga caaacgccca aaagccggtg aaacggttct 3360361 tggcacgtca tttcagactg tgccgggcgg caaaggagca aatcaggccg ttgccgcagc 3360421 cagacttggg gcgcaagtgt ttatggtcgg caaagttgga gacgatcatt atggaacagc 3360481 tattttgaat aatctcaaag ctaacggcgt tcgcactgat tatatggaac cggttacaca 3360541 tacggaaagc ggaaccgctc atattgtgct tgctgaaggc gacaacagca ttgtcgttgt 3360601 caaaggcgcg aacgatgaca tcaccccagc gtatgcgtta aacgcgctcg aacagattga 3360661 aaaggtcgat atggtgctga ttcagcagga aatcccagaa gaaacggttg atgaggtgtg 3360721 caaatactgc cattctcacg atatcccgat catactaaac ccagcaccgg cccgcccgct 3360781 caagcaggaa acaattgatc acgctaccta tctgacgccg aatgaacacg aggcttcgat 3360841 tttattccct gagcttacca tttccgaagc tctggcgctt tatccggcaa agctctttat 3360901 tacggaagga aaacaaggcg tccgctattc ggctggcagc aaagaggtgc tcatcccgtc 3360961 cttccctgta gaacccgttg atacaaccgg agccggtgat acgtttaacg cagcatttgc 3361021 cgtggccctg gctgagggaa aagacattga agccgcattg cggtttgcca atcgtgccgc 3361081 ttccctttct gtctgctcct tcggtgccca aggcggaatg ccgacaagaa atgaagtaga 3361141 ggagctgctg tcatgaaaaa acacggtata ctgaacagcc atcttgccaa gattttagcc 3361201 gaccttggcc acactgataa aattgtcatc gcggatgccg gactgccggt tcctgacggc 3361261 gttttgaaaa ttgatctttc actgaagccg ggccttccgg ctttccaaga tacagcggca 3361321 gtactggctg aggaaatggc ggtcgaaaaa gtcattgctg cagctgaaat aaaagcatcc 3361381 aatcaggaga atgcgaaatt tctagaaaat cttttctctg aacaagagat tgaatacctt 3361441 tctcacgagg agtttaagct gctgacaaaa gatgcaaagg cagtcataag aacaggagaa 3361501 ttcacaccat atgccaactg catcctgcag gcaggtgtac ttttctagaa aggaagatga 3361561 aacatgcaga ttgaaatgaa agacattcat aaaacattcg gaaaaaatca ggtgctgtca 3361621 ggcgtttcct ttcagctcat gcctggcgag gttcacgcat taatgggaga aaacggcgcc 3361681 ggcaagtcca cgcttatgaa cattttgaca ggcctgcaca aagcagataa aggtcaaatc 3361741 agcataaacg gaaacgaaac gtatttttcc aatccgaaag aagcggaaca gcatggaata 3361801 gcctttatcc atcaggaatt gaatatctgg ccggaaatga ccgttcttga gaatctattt 3361861 atcggtaaag agatatcctc caagctgggc gttttacaaa caagaaaaat gaaagcgcta 3361921 gcaaaagagc aatttgacaa actttccgtc tctctttctc ttgatcaaga agccggcgaa 3361981 tgttccgtcg gacagcagca aatgatcgaa attgcaaaag cgcttatgac aaatgccgag 3362041 gtaatcatta tggatgaacc gaccgcagcg ttgactgaac gtgaaatcag caagctcttt 3362101 gaggtcatta cagcgttaaa aaagaacggc gtctccattg tctatatttc gcatcgcatg 3362161 gaagaaattt ttgcgatttg cgacagaatt accatcatgc gtgacggaaa aacggtagat 3362221 acaacaaaca tctcagaaac tgattttgat gaagtcgtca aaaaaatggt cggacgggag 3362281 ctgactgaac gatatccaaa acgcactcct tctctcggtg acaaagtatt cgaggtgaaa 3362341 aatgcttccg taaaagggag ttttgaggac gtcagctttt atgtgcgttc cggtgagatc 3362401 gtcggtgttt caggattaat gggagccggc cggacagaaa tgatgagagc gctgttcggc 3362461 gttgacaggc tggacacggg tgagatatgg atcgctggga aaaaaacggc tattaagaac 3362521 ccgcaggaag ccgtgaaaaa aggtctcggc tttattacag agaatcgcaa ggatgaaggg 3362581 ctcctgctcg acacctcgat ccgcgaaaat attgccctgc ccaatctgtc cagcttctca 3362641 ccaaagggtc tcattgatca taagcgggag gctgaatttg tcgatctgtt aatcaagcgc 3362701 ctcactatca aaacagcatc accggaaacg cacgcacgcc atttatcagg aggaaaccag 3362761 caaaaagtgg tgatagccaa gtggatcggc atcggaccga aagtgcttat cttggatgag 3362821 ccaaccagag gtgtggatgt tggcgccaaa cgagagattt atacgctgat gaatgagctg 3362881 accgaacgcg gtgtcgctat catcatggtg tcatcagagc ttcctgaaat tctgggaatg 3362941 agcgatcgga ttatcgttgt ccatgaaggc agaatcagcg gcgaaatcca tgcgcgagaa 3363001 gcaacacaag aacgaattat gacacttgcc acgggagggc ggtaatatga aaacggaaca 3363061 actgcaaaca gaacaaaaac ggattcactt cgacggagtc atgcaaaaac tcggcccgtt 3363121 tcttggttta tttattctcg ttatcattgt atctatttta aatcccagct ttcttgaacc 3363181 gctgaatatt ttaaacctgc ttcgccaggt cgccattaac ggattaatcg cgttcgggat 3363241 gacctttgtt attttgacag gcggcattga tctttctgtt ggcgctattc ttgccctgtc 3363301 cagtgcttta gttgcgggga tgattgtgtc cggtgtcgat ccggttctcg cgatcatcct 3363361 tggctgtatc attggtgccg tactaggcat gatcaacgga ttattgatta ctaaaggaaa 3363421 aatggcgccc tttatcgcca cgcttgcgac catgactgtg tttcgcggac tgacgctagt 3363481 gtatacagat ggaaatccga ttaccggact tggcacaaac tacggttttc agatgttcgg 3363541 acgcggttac tttttaggca ttcctgtacc ggcaattacg atggttcttg cctttgtcat 3363601 cctttgggtg cttcttcata aaacaccatt cggacgccga acgtacgcta tcggcggcaa 3363661 cgaaaaagcc gcgctcattt caggcatcaa agtgacgcgc gtgaaagtga tgatctattc 3363721 tttagccggg cttttatccg ctcttgcagg tgccatattg acttcccgcc tgcattcggc 3363781 ccagccgact gcgggagaat cgtacgaact tgatgctatc gcggcagtcg tcttaggagg 3363841 gacaagtctt tccggcggcc gaggacgcat tgtcggcacg ttaatcgggg tgctgatcat 3363901 cggcacactt aataacggac ttaatctgct tggcgtctca tcattttatc agctggttgt 3363961 caaagggatt gttatcttaa ttgcggtatt gttagaccgc aagaagtcag cttaggaggg 3364021 ttttacatga aaaaggctgt atccgtcatt ttaacgttat cattattttt gttaaccgcc 3364081 tgttcgcttg agcctcccca atgggcaaag ccatcaaact cggggaacaa aaaggaattc 3364141 accattggct tgtccgtctc aacgcttaat aatccttttt ttgtctcatt aaaaaagggt 3364201 atcgaaaaag aagctaaaaa acggggaatg aaagtcatca ttgttgatgc acaaaatgat 3364261 tcatcgaaac agacgagtga cgtggaagat ttaattcagc aaggtgttga tgcattatta 3364321 atcaacccga ctgattcttc ggcgatctca acggcagtag aatctgcaaa cgcagtcggt 3364381 gtgcccgtcg taacaatcga tcgatctgcg gaacaaggaa aagttgaaac cctcgttgct 3364441 tccgataatg taaaaggcgg tgaaatggcc gcggcgttta ttgccgacaa acttggaaaa 3364501 ggagcaaagg tggcagagct tgaaggcgtc cccggcgcat ctgccacacg ggaacgcggc 3364561 tcaggattcc ataacatcgc agaccaaaag ctccaagttg tcacaaaaca atcagctgac 3364621 tttgaccgca cgaaaggcct gactgtcatg gaaaacctgc tgcagggaca tcctgatatc 3364681 caagctgttt ttgctcacaa cgatgaaatg gcgctcggtg ctctcgaggc aattaacagc 3364741 tcggggaaag acatattggt gatcggtttt gacggcaata aagatgcgct cgcttccatt 3364801 aaagacagaa agctgtcagc caccgtcgct cagcagcctg aattaatcgg taaattggct 3364861 acagaagcag cagatgatat tttgcacggg aaaaaagtgc aaaaaacaat atccgcgcct 3364921 ctcaaactag aaacacaaaa ataattgtct gatgtttagg aacctgcgat aacgtgaata 3364981 gagatataga atgaattatt tctcttacgt gaggagagga acggcatgaa caaaccaaca 3365041 aaactatttt caacattagc acttgcggct ggaatgactg cggcggctgc tggcggcgct 3365101 ggcacgatcc atgctcaaca gccagaaaca acggtaagca ttgatgattt atacagttat 3365161 ccgattgatt cttatttggt atcagcagag gctctaaatg tcagaacgaa gccttccgca 3365221 tcaagccaga aagccgatac gctgcactta ggagatagcc taaagctgat ttccttctca 3365281 aatgctgact gggcaaaggt taagtataaa aatggaaaaa caggatttgt atccactcat 3365341 tacattgtta aagcagcgac aacggtaaaa accaaaacaa aaacaaaagt gtatacatcc 3365401 gctgacggaa agagcattaa gactcttcca gcagacacaa gcgtttcttt tttaggctgg 3365461 agtaaaacga ataaaggcgg ttttgatttt gattgggtat tcgttgatta cggcggtacg 3365521 acaggttata tgaaaacaaa ggatttacac atgacaaaat aactgagagg gattccgcat 3365581 aaatgcggaa tcccttttat tatgaattga tttgtcacat tcccaagata tttctcagga 3365641 aatattgtcg tatgctgtgt cgaaacctta catgatcatc gacatttttg ttcacgctaa 3365701 aaagcggagg tgtaaatatg gatcaatttg aagcagcata tgaatcgtat aaagcccggc 3365761 aaacaactgc cgatcaagaa aatgttccat ctggaaaaga agaaattatt gcggttagaa 3365821 gaaatgagga agacaatatt atcgcagtga aaaccaatac aggaagagag ctcgactacc 3365881 ctactgcgct gtcagaagca aaatcaggaa aactcgctca tgttgatgtc ttccataaat 3365941 acgggcgtga cattttgcga agtgaaccgg acggcatcaa ggaaaataac ctgtctgagc 3366001 tgccggattt ttaaacaaat acagccctgc cgtatgttgg acagggctgt attttaaaca 3366061 aaaggctgct ggatgtattc ggctaaccgt tttgcactgt gagaaatatc ctctgcagct 3366121 gcataattca cgccatagaa cacatatgga ggcagatact tcatgccgat cagattactc 3366181 gtggcctgaa atggtttcaa tagctcactg atcgagtaat gatttgctcc gcccgcttga 3366241 tatttttccg cttcgctccc tgttgataca gccagcatca gctccttgcc atgcaaggca 3366301 tttccttctg aaccaaaagc ccagccataa gtcagcacaa gatcctgcca ttttttcaag 3366361 agcggcggag agctgtacca atatagcggg aattgaaaga caatccgatc gtattcctcg 3366421 cacagctgct gttccttcgc aacatctatc gcttcatccg ggtattcctt ataaagatcc 3366481 cgtactgtga tattgtcatg tttactcaat tcctcagccc acgccttatt aacaactgag 3366541 gtctccatat gaggatgcac tgccaaaacc aatattttca tcagaccaca cctttactgt 3366601 tttgatgtta ttttatctaa aatcaggaaa agagccaaat aaaaagaaag ccctgctaaa 3366661 aggggctttc tttttttctt ttattcaggg cttccttcag ttgtttcgat atctttcgca 3366721 aaatcagggt tatccagatt cgcattaaag aaatccgctg tgttcggaag tctgagattc 3366781 atgttcattt tttgagaaat cgtaaccgtg caatcctcaa gcacatagtc aaaaacgtgt 3366841 ccgcctgaat tgcgtccttc gtcaatgaag tgcaggtgat agccagaaac ggcgattccg 3366901 tttgcataag ctggtgtcaa gaaacctaca atcgttcctc tcacgttgtc gaagttgaaa 3366961 atcggctgtg ttttgaccgc ttcaaccatt ggcacgtaag gtttttcttg aagttctact 3367021 gttcttgtct gcaccttttt aaacaatccg tcaatgcgaa ttgcataaaa taagtttctg 3367081 cttggcagca tgctgttgat ctctttttca aagtcttcgc gtgtcatttt cgcatcaatt 3367141 ttgtgcgtca tgtccggtgt aaagaacgta aatgaacaga acggtgaacg gtctccattt 3367201 tggaccggtg tcgcggttcc gtctgagcga agacggtaaa attcgccgtc aaacccaatc 3367261 agctctccgt caagcttgtt aaaggttccg ataccgaagt ctccatattt cggaatctct 3367321 gacagttcaa aatctccgtc atatactccg tctaatagag aagtcattgt tgatacttga 3367381 taaatctggc tcacaggctg atctttttga ccacggctga gcacttgaat gttgctttct 3367441 cgtttcatat ttcccttcac tccttttatt tagtgctgtt cataaaacag tgtcgtgatg 3367501 cgcagagtgc tagagagctt tcgttttcat gagttccccg aattctttcg gaagcttgtc 3367561 acttgctaaa ttaatgttat cactgtagtc aaccgggaca tcgatgatga caggaccttc 3367621 agcgttcatg ccttgacgca gaacatctgc cagctggtct ggtgattcta cgcgcaagcc 3367681 agttgctccg aagctttccg catatttcac gatatcgata tttccgaaat cgaccgcaga 3367741 tgtacggtta tattttttca attgctggaa tgcaaccatg tcatatgtgc tgtcgttcca 3367801 tacaatgtgt acaattggtg cttttagtcg aactgctgtc tctaattcca ttgctgagaa 3367861 taagaaaccg ccgtcaccag agacagaaac cactttttct cccggtttca ccaatgaagc 3367921 gccgattgcc caaggaagcg caacgccgag tgtttgcata ccgttactga tcattaatgt 3367981 taacggctcg tagctgcgga aataacgtga catccaaatg gcgtgcgaac cgatatcgca 3368041 agttactgta acatgatcat cgactgcatt acgcaactct ttaacgattt caagagggtg 3368101 cgctctgtct gatttccaat ctgcaggcac ctgctcacct tcatgcatat attgttttaa 3368161 atcagaaagg attttctgct cacgctctgc aaattccact ttcacagcat cgtgttcgat 3368221 atgattgatc gtggacggaa tgtcaccgat caattcaaga tcaggctggt aagcatgatc 3368281 aatgtcagcg ataatctcgt ctaaatggat aattgtccgg tctccattga tattccagaa 3368341 tttcggatca tattcaatcg ggtcatagcc gatcgtcaga acaacatctg cctgctctag 3368401 cagtaaatcg ccaggctggt tgcggaacaa accgatacgg ccaaaatatt gatcctctaa 3368461 atctctagaa agggtaccgg cagcttgata tgtttcaaca aatggaagct gaaccttttt 3368521 caaaagcttg cgaaccgctt taattgcttc cggtcttccg cctttcatgc cgaccaaaac 3368581 gacaggaagt tttgctgttt ggatttttgc tatggccgca ctgattgcat catctgctgc 3368641 aggaccgagt tttggcgctg caacagcacg cacgtttttc gtatttgtga cttcattcac 3368701 aacatcttgc ggaaagctca caaaagcggc cccagcctgc cctgctgacg ctatcctaaa 3368761 tgcatttgta acagcttccg gtatattttt tacatcttga acttctacac tgtattttgt 3368821 aatcggctgg aatagcgccg cattatccaa agattgatgt gtccgtttta aacgatctgc 3368881 acggatcacg tttccagcaa gcgcaacgac agggtctcct tcagtgttcg ctgtcagcag 3368941 gcctgttgcc aagttagagg cacccggtcc tgatgtgact aacacgactc ccggttttcc 3369001 agttaaacgg ccgactgctt gggccatgaa tgctgcgttt tgttcgtgcc gggcaacgat 3369061 aatttcaggt cctttatctt gtaaagcgtc aaataccgca tcaatttttg cacctggaat 3369121 gccaaataca tgtgtgacac cttgctccac taagcaatca acaacaagct ccgcccctct 3369181 gtttttcaca agggattttt gttcttttgt tgcttttgtc aacaccctca ctccttatta 3369241 tgcattttaa acgtaaaatt ttaaatatct tgtgataagt ttcactatac actctttgga 3369301 aattgacctc caatatcgat tcgccttatg attaatatgt aatacgaatt attaacctat 3369361 ggaaaggaat gcatattgaa tggagcttcg ccatcttcaa tactttatcg cagtagccga 3369421 agagcttcat ttcggaaagg ctgcccggcg gctgaacatg acgcagcctc ctctcagcca 3369481 gcagatcaaa cagctggagg aagaagtcgg agttacgctt ctgaaaagga caaaacgatt 3369541 tgtcgagctt accgcagcag gagaaatctt tttaaatcat tgccgcatgg cattgatgca 3369601 aatcggacaa ggaattgaac tggcacagcg gacggcccgc ggcgagcaag gccttctcgt 3369661 aatcggtttt gtcggatcag ctacatatga atttctgccg ccgattgtcc gggaatatcg 3369721 taaaaaattc ccatctgtga aaatagaact gcgtgaaata tcctcgtcta ggcagcagga 3369781 ggagctacta aagggcaaca ttgatattgg tatacttcat cctcccttac agcatacagc 3369841 tttacatatc gaaaccgccc aaagcagccc ttgtgtttta gctttgccta agcaacaccc 3369901 attgacttct aaggaatcaa ttacgattga ggatttaaga gatgaaccaa ttattactgt 3369961 tgctaaagaa gcatggccta ctctatacat ggattttatt cagttctgtg aacaagcggg 3370021 cttcagaccc aacattgtcc aggaagccac agaatatcaa atggtgattg gtttagtcag 3370081 tgccggaatt ggtatgacat ttgttccttc ctcggccaaa aaattattta atttggatgt 3370141 tacttatcga aaaatggacc aaatacagct taatgcagaa tgggttatcg cttaccgcaa 3370201 agacaatcat aatccgctta taaagcattt tattcatatt tcaaattgtc agcagacaag 3370261 aactaaagag agtgatgcag gtacatgaac aatacttgca atctcttttt tcttttggga 3370321 ttcttatgga atttttatta atttaatata atcgcttagt acaactttat atcagtatac 3370381 gtatacatac agtacaaata gttggcaagg acatcagtaa gcgcaggaca ttagtttgat 3370441 tttaaaaatg aaagatagag aggtgaagta aattattgag ttcaccggca tattcacatt 3370501 gctcgctttt ttcgtaacaa tgatttttat tttctggaga ccaaaaggac taaatgaagc 3370561 tatccccgcc acatttggcg ctttaatggt tttattgtgc ggaagtgtgt cattggcaga 3370621 cttaggggaa atcggaacaa aagtcacggg tgcatcggtt acaatccttg ccactatgat 3370681 tatggccatt gcactagaaa gctttggttt cttttattgg gtggctgcaa aactgctcca 3370741 acaatccaag ggttcaggca tcaagctttt ttggctaacc aatttgctct gctttctcat 3370801 gaccattttc cttaataatg atgggagcat tttgatcaca actccaatcc ttttgcttgt 3370861 actaaaatat ttaggtttaa aaaaacatca aaaagcccca tatttattaa gcggtgtttt 3370921 aatagccaca gcctctagcg caccgattgg cgtaagtaat attgttaatt taatttctct 3370981 caaaatcatt ggaatggatc tatatcttca caccgccatg atgtttgtcc ctagtatgat 3371041 gggactcatt tttatgactt gtctactgtt tatgttcttt tataaacgtc ttcccaaaag 3371101 cctgccagat ataccgggcc attttcagtc tctgcggcat agaaggtacc atcctcttca 3371161 ttcgccatca gctcctttac cagaacgaaa tcaaacaaaa atcatgttgt ttgtgcttgc 3371221 atttgttttt ctcgtcagaa tgagtctatt tgcagcatca tataccggta tttctgttcc 3371281 tctagtcgct gtcatcggat cttttatcct gttgagctgg agatggattt atttcaaaac 3371341 ctccccaaga gacttgttat ataaatcgcc ttggcacatt tttatattcg cttttactat 3371401 gtatgtctta atttatggtc tgcataatat tggattcaca gagttacttg tgagttattt 3371461 tgaacctgtg gtttctggaa gcctcgccca tgcaactttc gcatcaggta tctctacttc 3371521 agttttttct aatctcttta acaaccatcc agcgttaatg atcagtactt ttaccttaac 3371581 tgaaatgacc ctgaatcctt caacaacaaa aatcatctac ttggcaaata ttatcggcag 3371641 tgatatcggt tcattattat tacctatggg aaccttagca acgcttattt ggatgcatat 3371701 attaaaacag catgatgaaa gtatttcatg gggcgaatat ataaaaacga ccattatcat 3371761 cattccgctg actgttcttt ttacgttaac atgtttatat ttttggatca gttggttatt 3371821 tctttagcac agtatgaaac gaaaaactgc cttctgcttt tcaagagggc agttttgtat 3371881 acactaggga agatgcattg tctttagatg atttaacttc caaatgactg gctctccact 3371941 tgcgttaata agctcaatga tattattaga gacacccttt aatagtccga ctttttctgg 3372001 cacctctccc atatcaaata tgaccaattc accaatattt tttttgatct gctcctcaaa 3372061 attacgcaca agaggaactt tggaaggcac gaccggcaat tgtgagttgt caagagtata 3372121 cggtgtttgt tcagttgaat aaggggtaaa ccattttaaa tgatgcatag atataaaaag 3372181 tattttaaat acgggtgaga aaaatacaat ataatcgttt aaaacatttg taacatatcc 3372241 atggatcgat cgacccccag ttacataaac ttcaataaac tggcctttga ccttgtttaa 3372301 tgtatttcta tatgaaaaag cttgagtttc tgcctctatc attggatctt ccggattgat 3372361 caaaaatggc ttctcagtac tggtcactat tttcgccttg tttatttgat gaagatgcaa 3372421 caagggaata taaagataat tgcagccatc aaaaataaca aaaatatcct gtccgatatc 3372481 tatgagggtg ccgacaaacc ttgtatctcc tgaaatgaca acctcaacat ctgtgttaag 3372541 gaattgattc aaacctttca cgattctcct cctttaactg aaaaagggca tcactttatc 3372601 tgatgctcct ccattatcta ttaaaattta cgtttccagt gatagtctat cgttctgaca 3372661 atcgtttcat agctataatc ttccttttgt tttcctgaac tttttattga acttgaatag 3372721 cctggtgatc ttgatgattg ataatctgaa gatcttggtg atcgtttaga tgattttgat 3372781 gattgataat ctgaagattt taatgatcgt ttagatgatt ttgaagaact ttttgaacgt 3372841 gacgaacggc cagatttgga tgattgataa tccgaagatt ttagtgatcg tttagatgat 3372901 tttgaagaac tttttgaacg tgacgaacga ccagatttgg atgattgatc atctgaagat 3372961 tttagtgatc gtttagatga ttttgatgag ctatatgatt ttgaagaaat gaacgaattg 3373021 ctgtccttat cattattgtc ttcctggttt tgttcatttt tttgatcctc ttttttgtac 3373081 gacccttttg gacctaagct gatgcttttt atgtgaaaag gatagatgcg aagcacctct 3373141 tgatttttca ctatagtata atggccgtcg gcattatcta caaggatacc ctcaatggct 3373201 tccggacctc cacgattaat tgaaacccat ttatgagtca gactcttaaa aacctcgctt 3373261 aaatcatcag cttccaaaac tccaactggc gtctgctctt ctattttcaa atcaggctcg 3373321 tgtttactta tacttttgat gtgatggata ttaaaataca ctaccccatc ctcatttgtg 3373381 tttaacgcag cgtaatcatc tcccagccag accaatcttc cttttttaga ttccggaccc 3373441 ccttggttaa attgaactga ttggtttatt aaatgtccga ttaagctatg aaaatcatca 3373501 gcatcgagca tttcctcagt ctcaattgtt gtggtgctat tattggtatc ctcagtaata 3373561 cttttcacat gctccaactg ataataaatt attttttttt cagcttgtaa agctatataa 3373621 tctgatttta cagctgttaa ttttcctttt ttagattccg gacctccacg atatacagta 3373681 acaattttat ctttcattga gtgcaaaaag ttataatacg atatttcatt atttgaatga 3373741 tatttcattc tcctcttgct cattcaaatt cctcctagtc acttatacat agatgataaa 3373801 catactgcat atatacgtgt cacatttatt tgttgaacta attcaatagc ctaattgtcg 3373861 ctttttccgc gaatacccat tttcacgcat tcataaaata cttaaatgat ctttgaggta 3373921 ttgtgaacgg tttttaatat actcgcagat cacatccggc tcacggtcaa aacgctcaat 3373981 atcattcttt ttatacgggt ccatgaggac aaacggccta atccgttcat acatcgccat 3374041 gattttcggt tccatatatt ctattgtaaa aagagattgg agcgtttttt ctaacaggcg 3374101 cttgtaggac ttgcgaaact cggattcatc caatatccgg gcggttagtg tattaaatcc 3374161 ttgaattctt acataatcgg cagccatccg ctctccatgg atatccctgc cccaagtcgc 3374221 atcataatcc caaggaatca cctcaaataa tccggtttcc ccgcttctgt ataatgcgta 3374281 gttgtggaca aacccgtcat agttcgaggt gaatacaata ccagcaagcc agcgcaaata 3374341 cttatcgaca tccacgtgtt ttgtcacttc tgacttaaac tgagctttag ggaccgtatt 3374401 aattttaaaa atcatatctt gtaaataaaa atcatcttcc tcagtccctg ttttcttttc 3374461 atatccaagc tccagcgatg ttttcgtttc cctttctaaa tcgctcatca gagaaaagtt 3374521 ggcatcatca tccaccgcat aaaaaatcgc gccatcagcc agcttccttt tcgccaaata 3374581 atattcatct acggattcaa gttcaagata aaccccttca ttcttcccat tcatctttac 3374641 aaacgcaaac tctgcctttg gagacagtgt ccctagctcc gagaaaaaat ccagagacaa 3374701 tttgtttctc atcaaggaag ggtctttata ctccgcattt aagtgaatct ctcgcgcgcc 3374761 gcggaatgtt ttcggctgat aaaaggaaat atggtatgac ttctttttga agtctctgat 3374821 atgtgatccc cgataagcga tatcaatatc cagccttttt tgatttacct tcatcacagc 3374881 tggcaccgga tcatcgtccc atatatcctt ttttaattca cgcaagtctt ttggatgaac 3374941 aaacagctga taaagcggta aattggattg attcttcatc cataatcctc cttacaaatt 3375001 ttaggctttt atttttataa gatctcagcg gaacacttat acacttttta aaaccgcgcg 3375061 tactatgagg gtagtaagga tcttcatcct taacatattt ttaaaaggag gatttcaaat 3375121 tgggccacta ttcccattct gacatcgaag aagcggtgaa atccgcaaaa aaagaaggtt 3375181 taaaggatta tttataccaa gagcctcatg gaaaaaaacg cagtcataaa aagtcgcacc 3375241 gcactcacaa aaaatctcgc agccataaaa aatcatactg ctctcacaaa aaatctcgca 3375301 gtcacaaaaa atcattctgt tctcacaaaa aatctcgcag ccacaaaaaa tcatactgct 3375361 ctcacaagaa atctcgcagc cacaaaaaat cgtaccgttc tcacaaaaaa tctcgcagct 3375421 ataaaaaatc ttaccgttct tacaaaaaat ctcgtagcta taaaaaatct tgccgttctt 3375481 acaaaaaatc tcgcagctac aaaaagtctt actgttctca caagaaaaaa tctcgcagct 3375541 ataagaagtc atgccgcaca cacaaaaaat cttatcgttc ccataagaaa tactacaaaa 3375601 aaccgcacca ccactgcgac gactacaaaa gacacgatga ttatgacagc aaaaaagaat 3375661 actggaaaga cggcaattgc tgggtagtca aaaagaaata caaataatct aagttttcat 3375721 tgtttcaata ggctgccggc ggaggtacgg aagcctattt ttttatttgc cctgtattag 3375781 atatatgtca tgacataaca tatgcaaccc gcatcatttg gtttccttta aaccatttcg 3375841 ttataatcaa ggtatcctaa cgataaaggc ggttgttgct atgtacatat ttcaagctga 3375901 tcagcttagt gccaaagaca catacaagct attgtcaggt accgttattc cccgccccat 3375961 tgcatttgtg acaacacttt cttcaggagg agcggtaaat gccgcgcctt tcagttttta 3376021 taacgtcgtc agctcagatc ctccgcttct cagtatttct gttaacagga cggaaggacg 3376081 ccaaaaagat acagcacgaa acgcagtgga gaacggagaa tttgtcgttc atgtcagtga 3376141 tgaagccatc attgaagata tcaatgaaac agctgcaagc ttaaggccgg atgaaagcga 3376201 gcttacacgc acctcgcttc atcctgttga aagcaaagct gtttcagttc ccggcattaa 3376261 ggaagcccgc gttcgctttg agtgcaaatt agagcggcat attacctttg acaatgatca 3376321 aggcatcact acagcagatc tgctcatcgg aagagttgtc tgcttccacc tagatgaaaa 3376381 ggtgtatgat gcagaaaagg gatatatttt aacggatgaa ttaaagcctg cctcacgatt 3376441 ggcgggaaat cactatgcca agctggggga agaattcaca ctgattcgtc ccagctgaag 3376501 agaaggacta tttaaataga agaaactagt caaaaagacc ttatgattac aaaatatcgc 3376561 ctgtaaataa ctgaaaaaat atcaaaaaaa agaacaccca gagcaagctc ggggtgttct 3376621 tttatgaaac gtttttcctt tttcttcgta taaaggtaga ttaggaggaa ttggaatgac 3376681 aaacttttgg attttaatgc tgatcgctat taccatcagt ctcgcctctc aattttttat 3376741 aaagaaaaaa tacggtattg ataaatccgg ctggcgatat aagcatgtca gcaatacaca 3376801 caaatggatc gaaatcactt tacttatttt gtttgtgttt tcactctcct tttttccagt 3376861 tgaatatttg cttcttttat tttttattgt gattgactca atacgtattt ttatggagtg 3376921 gcattataga cctgaagata aacagtatat gtaccacatt gtagaggtct cccttatgtt 3376981 tatgcttttg atttatgttt gtaccctata gttatttaaa tccccacagc cgctccgtct 3377041 ccccgaggat cggctccgcc ttggagaaag ccttcttcat caactttgat tgcagccgct 3377101 tgtcccatca gcggatcata gtcaccgaca acctccacga gatgcccgct gtctttcagt 3377161 ttttggattg ttttgtctgt gaatctgccc tcgactctga gaccttcgta ttcctctccc 3377221 cacgttctgc cccataccca gcgcggttcg ctgattgcct gctgtggatg cattccgtag 3377281 tccagcattc gggtaatgat ggccgtctgg gtctgcggct ggccttcgcc gccttgtgtg 3377341 ccgtacagaa tttttggctt tccgccttta cagaccatag ccggcatcaa cgtatggaag 3377401 gtgcgctttc tcggttcaag cgtgttgaca tgattttcat ccagtgagaa aaacgatccg 3377461 cggttttgca gtaatatgcc tgtatcaccg gcagtgactg ccgagccaaa ttcaaagtac 3377521 aggctttgaa tgaatgacac tgcgttgcca tccgcatcga ttacggccgc atatgccgta 3377581 tcacttccca ccggcctgct ttctgccggt attgcgagat agccgatttc ttctgccaat 3377641 tgttttgcat aacgtttgtc caaaagcctt tcaagcggaa tgtctgcaaa cgccggatca 3377701 gtcaggacgg catcccgatc tagaaaactc tttttcaatg cctccacaag cacgtgataa 3377761 tactcaaatg aaccgtgttc gatttgggtg aaatcatagt tttccaaaat gttcagtgtt 3377821 aataaaccgg taaatccctg agaattcggc ggcgcctgat acacactgta tcctcgataa 3377881 tcacttgata caggcgctgc ccactcaccc cgatgcgctt taaaatcatc gattgtcatg 3377941 taactgccgt tattctgtaa atgtgagaca atccgctgag cgagatctcc ttcataaaat 3378001 gcgcttcttc ctttttcagc aatcaagttc agactgtctg caagctcttt ttgcacaaac 3378061 cgctctcccg ggacaggtgc tttgcccctt ctcgtgaaga tgtcagccgt gtaaggcgtg 3378121 gaagccagca gttcaatatt cttttctgtg tgacgacact gatcagctga tacaggaaac 3378181 ccattttggg cataatcgcg tgcgggctcc aatacatctg caagagacag acgcccgtac 3378241 tccttcagga ccgcatccca gctatcaacc attcccggca cggtaatagc actgtcaatt 3378301 ccccgcagcg gaatcgcgct ttttccctta tatacatctc tcgttacgtt ttttcctgaa 3378361 cggccgctgc cattgtagac ttttactgcc tttgtttcct ggtgaaaggt cagccaaaag 3378421 gaatccccgc caagtccggt catatgcggg tacacaaccg caagacaagc actcaccgca 3378481 acagcggcgt caaacgcgtt gcctccctta tccagtatgc ggtttccggc ttgagaagcg 3378541 agataatgcg gactgacgac catttgcttt gtaccgatga cagatttgtt catcacaagt 3378601 cccctttttt aagaaatttt cttcagtata gggagcctga tttttcacat ctactgatcc 3378661 ggcagaaaaa ctgacgaact ttcttctttt cgcaaataat aagatatttt cgcattcatt 3378721 tcgaaaacaa atgaaaaatt attatttcta tacgtaactt ttatgataaa atgattgcta 3378781 aaaggctacg aaagcaggtg gagcaattga gtcatgaata tcaaatcccc aaccttgtac 3378841 ttgatgagac tgataaacaa attctcacga ttttgcatga agaaggcaga atttcttata 3378901 cggatcttgg caaaagagtc gatttgtcac gggtcgccgt tcaggcccgt atcaaccaat 3378961 taattgaagc cggtgttatt gaaaaattca ccgctgtcat caatcccgct aaaatcggca 3379021 tccatgtttc cgtgtttttc aatgtcgagg tagaaccgca atttttagaa gaggtcgctc 3379081 ttaagcttga ggaagagcct gcggtcacca gcctttatca catgacaggc ccgagcaagc 3379141 tgcatatgca tgggatcttt accaacgatc aagaaatgga agaattctta acaaaacggc 3379201 tgtatccatt gcgaggcgtc gtcagtgttg attgccagat gctgatcaaa cgatacaaaa 3379261 gccgtatggg aatgaagctg taaaggagag aaacaaatga aaaaccatcc ttatcgggat 3379321 atgacggccg caatggttcg caccggcata ttagggttcg gcggcggacc ttccgtgatt 3379381 ccgctgatcc gccatgaagc ggtcaataaa tataaatgga ttgacgatga tgaattcgga 3379441 gaaatattag caatcgctaa tgcgcttccc ggaccgattg ccaccaaaat ggctgcttat 3379501 ctgggcttta agctaaaagg cacattaggt gcaattgtgg cgatcctcgc ccacattctg 3379561 cctacatgtc ttgcgatggt gggcttgttt gcggctgtaa atgtgttaag ccattcagca 3379621 attgttgcag gtatgattgg tgccgtcacg ccggtaattg cggtcatgct cggaatcatg 3379681 gcgtacgagt ttggccaaaa agcgcttaaa ggtttcggct gggttaccgg catcctgttt 3379741 tttatcatcg cttttatcgg cctgcaaact ttacagatta atcccggcct ggtcattatc 3379801 attttcttag cttacggggc gtttcatttt aaactgaaag acaaaatcac aaataaacat 3379861 tcaaaagata aaggaatgtc agcctcatga tatcgatcta tttatttatg gcgtttttta 3379921 tcgcaaacct actgggatat ggcggcggac ctgcgtctat cccgctaatg tttgaagaag 3379981 tcgtaaacag atacagctgg ctctcaaacg atcaattctc aaatatgctc gcacttgcga 3380041 acgcattgcc gggcccgatc gccacgaaaa tcgctgcgta tgtcggctac agcgcaggcg 3380101 ggtggcccgg cttcctaatt gccctgatcg caaccgtcgt accgtcggcg ctcgcattga 3380161 tcgtcctgct gcgcatcatc cagcgcttcc gccaatcacc tgtcatcaaa ggcatgacgc 3380221 tgtccgtcca gcctgtcatc gcggtcatga tgctcattct tacctggcaa atcggcgcag 3380281 acggcatcaa agcgatcggc tgggtccaat cgatcgtgat tacgggaatt tcgctccttg 3380341 ccatgacaaa attcaaaatg catccggcat ttttgattat tgcggcgttt ttatatgggg 3380401 gccttgtgat cccttattta tagaaaaaag cacctggaca ggtgcttttt tattttagcc 3380461 cagaaatgcc gtttgatatg acagctgttt cttctcctgc gtcactcttg atcatgtgct 3380521 tgacttgcag cgtggttcct gccattctca cagattgctt caactgggac gaattggttt 3380581 caacttgtat ccaaacagga ggctggacct tccaaaataa atagagtgca agaatcagca 3380641 agccagcaat gaccgacagc aaaaacttca tatcgcatcg cttcttttca gtaagcggct 3380701 cgcagcggac agcgcctgat gatcacgaag aatatcgcct ggacgattgc cttctcccag 3380761 cacatagcct ttaaaggaca ttcccataaa atgaaaaata tgttcgaatt gctgaatcag 3380821 cggcagccct tttatttttg gattgtctcc gcccactgct attacatatg cctgtttcac 3380881 tgacatttgc tgtttaaaat caggaaatct cggatctctc aacgtctgtg accagcgatc 3380941 aataaacagc tttaatgtcc ctgacatgcc aaaccaataa attggggtgg cgaatataag 3381001 aatatggcac tgcaatatcc gttcaatgat agaatcgtag tcatcttgaa caggacgaaa 3381061 gccgccttgg gcgtgacgca gatcttcaat tggttgaatt ggatatttct gcaaataaat 3381121 gtgctccgca tcgaatcctt gaacagcctt ctccgcaaga acatccgtat ttccgccaga 3381181 ccgagttccg ccgttaataa ccgcaatttt catgatgcat ctgctccttt gtttacgaat 3381241 gattttcttc atcatataat ggattcatca atcaatacag atgattattt cgattaatcc 3381301 aatcgctaaa accgatttag aaaggaagag aacaagtgga attgaagcag ctgatcacct 3381361 ttattacggc ggctgaacat gtaaacttca ccctaaccgc caaaatgctt aattatgcac 3381421 aatcaagcgt tacctctcag atcaaatcac ttgaagaaga aatcggaacg cctttatttg 3381481 aacggctcgg caagcggctt atcttgacag aagcaggaaa aacgttcaaa tcttatgcac 3381541 agaagatcat tgcgttaaca gaagaagcga aaatggccac aaatcaagta agagaaacaa 3381601 ccggaacctt aaaaatcggg gcgacggaaa gccagtgcac ataccgcctg ccccctatca 3381661 taaaagaatt taaacaggct tttccccaag taaagctcat attcaaacca tatatctcca 3381721 atgaacaagc gaaagaacag ctcttacagg gccagcttga tatcaccttc atcttggatg 3381781 taaaccggat ggaagacgca ctgcacgttg aatctttgat tcaggatgag atcaaaatgg 3381841 tggctgctaa tgaccatcct tttcctgcgg atttaccagt aacattgaag gatcttcaaa 3381901 acgaaactct tctgctgaca gaggacggct gctcgtaccg cacgctcttt gagaacaatt 3381961 tgcatgactc cggtatctat cctaacaaat tggaattcgt cagcatagaa gccatcaaac 3382021 aatgcgtgat ggccggactt gggattggaa tcttgcctga aatgacagta aaagatgata 3382081 ttgcagcagg ccggatgaaa gaactcaatt ggcagagcga ttgccccgtt ttcactcaat 3382141 tagcatggca taaggacaag tggatgtctg cgccattaaa ggcttttatc gatttgacac 3382201 ggaaaacatt caaataaaac ctctccacaa ggacgacaag gtttttgaga ccagggcaca 3382261 cacatacaaa aaaaacactt gatgacttag agccccaagt gttacacgtg atttttctga 3382321 taaaacgttc gcaaaacatg cgtctcaagg tcagccaggc ggacagggat cggcagcctg 3382381 ctttcttgat tgatcaagct catcgtgatc tgatagctgc tgtctaaatc aatataatta 3382441 ccgcaagaca agaaaatagg cttcacgtcc cgccgcgttc gcagcgcccg tccatatacc 3382501 tcgccgtcaa tgataatatc ggtgtatgcg cctacttcaa tttcaggcgt cacgaaatcg 3382561 cagcctttga ttttgagata ggttttcgct atcccaatcg tcggcttgcc cagaaaaaaa 3382621 gccgcatggg tggcaacgcc catatgattg taatgcagat atccgttgcc atcaaacaag 3382681 aagacatccg gctccgtctc cagctttttc gccgcctcga tgatcaaggg cagctcgcga 3382741 aacgcaagaa aaccggaaac atacggcacg ctgattctcc ccatgctgtg cactttttca 3382801 atgacttctt ttgtatcagc gtcaattacg ataatacagc acactccgta tggttctcca 3382861 tcctgctccc aataggccag gtcgacgcct gcgcaggtgt tgatggagtc tggatggatc 3382921 gtgggggata ggttgatacg atttttaagg ttaaattgca cttgtaaaaa gtcttgttcc 3382981 tttttcatat caaatttatg cacatcaaat accttcataa cgattgctca ctctcgacct 3383041 aaattaatgt gagtctctct tctcgattct agtatttcaa aatgaggact atctgtatct 3383101 atctcgtact tatttaatag attgccttct tcatcccaat tcttttcaga aattagtatg 3383161 gaatgctcat actgttgctc actttttttc ctgccatttt caaaccaaat tatgcttata 3383221 ccgtgcaatt gcccatatcg gtattctttt tcactttttt tattcccgtt ttcataaaat 3383281 tcacatgtta aaccatgggc cagaccattc ttatatttag taaaatagat gatttgacca 3383341 tttggatata attcgtaagc cagccctgta aacggctggc cattttcgtc ttcaggatta 3383401 tctaaaatct catcacttac cgaagagaac cataaatcct caaagtccac tcccttttct 3383461 tttatactct tcatatcata ttcattttcc atactttaaa gcctccggta tataatttgt 3383521 attttgagtt atatattcac aatgtggaca tctaggcatt gggacacctt ctggcatctt 3383581 tttatttatt ttcctagcac ttactacata taccattaaa tcttttaaat ccgcatcagg 3383641 tctttgaagt aacgcttcat ttagagcatt aacttcggca tgagaacccg cccctgacgt 3383701 ctttatataa ccttctttaa gttctgtagg catatttaca attctatcat gaataagtgg 3383761 atgtagtacc ttaggtggct tcccatctat attgtttatt ccaaaataat aattgcctgt 3383821 ttttttgtcc aatacaccag ctaccgcagg gcctctttgt tttttagtta gaccagaaga 3383881 tttaattcta ctaagttcgt ttagtacttc tgcccttaga tttattcgat ggtgaagatc 3383941 ttctttagac aatacaccat gcttatttct taaatattga agcctagttt gtttttcttc 3384001 agtagtctta gcaatattgc taataaggct ttcattactc actttattga catatggagc 3384061 atttttttgg tacaaccgat caaagtagtg tgccaatcct gctccaccaa taatagtaat 3384121 agcttccagc gccccttgct tccgcttctc ctcagacact ttgtttccga acatatcccg 3384181 gcctgtgaca gcttctgaga atccgtttga cgcaacaagg ccgtatgcgc ccatttctgt 3384241 cattttgaga atgtctaagg atttgcctgt tttgtaggcg tctaatgcgt gttcagcagc 3384301 gatagctgct tttccggttt tgtagatggc ttttccgcct ttgaaggccc ggcctgccca 3384361 gccgacgact ggtatgaatc cggcagcggc catagctcct gctgtcacac gctccgcggt 3384421 ggagagtttt tctccggtaa ccggatcaac gccttcggtt gctcttttat aatcataata 3384481 gccagtgact tctccagtaa agttgcaaac tccatcccat gttttttcgt accacggttt 3384541 gtttgcttct tcctcggctt tttcctggag ccgtcttgct tctgcttgct gggtttttgc 3384601 atcgatatag gttgttcctt gattttctac ttcaatgacg cttttgtaga cttcattgct 3384661 gtggaaggct tttttgtcat agtacatagg ggatgcgctc ttcccattgc tggtggcctg 3384721 catgagaaca gaatatttgg tgagcactgc gttgtccaga gattctaaat tttgatattc 3384781 agtggtcagg gattcatcaa gcttatcgac agctgtgatt gtatcacgtc tgattttttg 3384841 ggcatcgccc atcttatctg catagtcgtc aagcgtgtac atgtcgagat caataatatc 3384901 gctgatgcct gacaaaatag aatcgatttc ttctttatga gcggagacaa tctctgaggc 3384961 tttcaggtct ccattgggca gctcatgatc caaaaaagaa gtttccacat atgaatcatt 3385021 cagttcttga tctttaatat ctcctgaaat gccgtttaaa aacgcaattt gagcagagac 3385081 aagcgtcagc cagctgtcta cgatttctgc ctgtccctga aaaaaatctt taatattgtc 3385141 cgcgccattt cctttaaaat tatcgcctaa atcggcaact ccctgaaacg cttttttcag 3385201 cgtattcagc tgctcttcaa gcgtctcata ttgctttttt ctgctcttcg cttcttcgat 3385261 taaagatttt gattcaaata ctttactcat cgcactgccc tttctgttct attttaccgc 3385321 tatcgcctcg tcctgctctt tgagtgaatc tacgttatcc tttgtatcct cgatattttt 3385381 ctgtaccgct tttttgtaat ctccgagcat ggttttgatg ttctcctcac gctcatggta 3385441 ttttttcgta taatcgaggc tgttttttcc gttggatcct gcggcgccga ttgatacgtc 3385501 agcaagcgca tctttgacag aatctaatgt tttgatgact gtgtcgtact tcagcttaat 3385561 ttctgacata aaaaaagatc accaccattt tagtttacta attgtatttc cgacttcttc 3385621 cgcgaactct tctccctttt taagaagatc tgctgcacca tttgctatga acaattccga 3385681 tgcatattta gctttatccc attcaagatc aaaaattttc ccgttaatcg aagccatata 3385741 ctcgttatat ttatcattca caatcttaga tgcttccgat ttcgcctctt ctcttccctt 3385801 gtcgaaatca tcggcttttg ttcccgtcca atgcttgccc aattccggtt tcacaatttc 3385861 tttgatttca gtgattgcct cttcttgcag tgtgtctatg tccttttttg cttttttcag 3385921 cttttcgatc ttgtcttcca cgtctgaaat ttttccgttg agcgaacttt tgatatccgc 3385981 tagcatactt tcataaccca tctgaatcac ctcttaatac tcaaaaagtc gtatggaggg 3386041 gctgatgaag atagactttt ccatacttta tttccatata ttatatttta aaatagccag 3386101 aaggcggctt aaatagggta aatggcttaa tttaggcata taacgctctt gaaatgtagg 3386161 tatttgatct tgtttttgtt cgttatacag ctaataaaag cgttttataa aatgaaatca 3386221 cctaatgtca tagttataaa ggcacttgaa agaggcagat gttgttgatc tgcctctttc 3386281 ggcgctgagc ttattgttca tgtttatgtt cttcatctgg tcggccatgt ctgattttgt 3386341 catttggctt ctattattcc ccccttctga ccctttggat caaaagcttg tattagctgc 3386401 agtcccagtt gtacagaacg tttgaaaagt cttttttcct tagatcttca ggtgtgatga 3386461 aaaaattggc gatgccgacg tctccccaca ttgaatcgat atcatcgtct gaatcaattt 3386521 gtaacagcat gatggtgtgt tctttatatg cgtattcccg gggatcatgc tgggtaaaag 3386581 aagcgtatcc gccaatttta tggccaaatc cgttttcagc cagttcatta taaatgtctt 3386641 cttcatcctc gccgaactga ccaaagaact ccattgtttc catgcccgta tactgctcaa 3386701 attgaaaatc tgtaggcagc acccattccg aagatttcac aggctcgact gccgcttctg 3386761 ataaaatcgg aaaatcacat tcgcctgtgc caataaatga aaaatcagaa acaagctcgt 3386821 catcgttttc tacgatattt tcaaaataga tcactctgaa attcttttgt tcacatcgat 3386881 cgtcaaaatt caatccatag acgtcatcat gaacagaaat gtagaactgc aggatacctg 3386941 aagaagggta gccgtcaagc tggggaatgt gcgagaaatt aatctgcgcc agaagtttca 3387001 tcggctgtcc attttcgtca gtcggatatg tttcatgctt ggggaaatag ggatcaccgg 3387061 caattttgct gtcatatcgt cctgttttcc cctttctcac attcagtttc acgtattctt 3387121 tcgctgattt ctccagcaag tcgcggtacg gtctcatttt ttcgggcaga tgattcatca 3387181 gattctctcc ttttccggca tctccaaggt tttattttct ggttttcttc taatgttttt 3387241 caaacgaatg tttaaagaag ccctacttct gcataatttt ccaaacaata gttaaatagt 3387301 agcaaatgta ttcagcaccc cgcaatagat gaaaaaaaga ctggtgcgca accagccttt 3387361 ctttttcatc tattgaattg cacctgacgg aacaaccgcc ttccgtccga cagaataata 3387421 ctccactcct gcagccaaag cctcatccaa tgtgtagcag tttctgccgt caaatatgag 3387481 cggcgtttcc atcaaatcct gataagccgc taacgggaat tgtttaatgt cagcccagtc 3387541 ggttaaaatc atgacggcgt cagacccttt gacagcttcc tcgatcgtct ctttatattc 3387601 aacagcttgc gggagaacat gctttgcatg gctaactgca atgggatcgt aggctctgat 3387661 acgggcgtcg agcgcagcga gacggtctgc aataacaatt gacggcgctt ctctcatatc 3387721 gtcggtattc ggtttaaatg acaggcctaa aagggcaatc gtttttcccg tcaccccacc 3387781 gagcctgttc agcgctttat caaccagcat cgcctgctga ttgttgttga ctttgataac 3387841 ggatttcagc agttcaaaat catgctcgac attgccggca atttgcacga gggcgtttgt 3387901 gtcctttgga aaacaagagc cgccgtagcc tatgcccgct tttaaaaact ggctcccgat 3387961 ccgcttatcc tgtcccatcc cgtatgcgac tgcttcaata tcggcgccga ccttttcaca 3388021 tatattcgaa atttcgttta taaaactgat cttagtggcc agaaaagcat ttgaggcata 3388081 tttgatcatc tcggcgcttc tgatatccgt ttggtaaatc gggatttgaa acggacggaa 3388141 gagctcctcc agcgtatttg ctgttttctc atcggccgtc ccgatcacga tcctgtcacc 3388201 atgaaaggta tcatagatcg ccgacccctc acgcaaaaat tccggattgg atgcgaccga 3388261 aatactgaca ggctccgcta gatgttcagt aatcagtcca ttaatcaaat cgtttgtccc 3388321 aacgggcact gtgcttttcg ttaccacgac tgtatctcgt ttgacatgct ttgcgatgcg 3388381 tttggccgca tctgtaattt gctccagatt ggcgtgcccg tcgcttttct gcggtgtgcc 3388441 gaccgctata aaaatgatgt ctgcctgtgc caagcctttc tcatagctcg tttcaaagtt 3388501 cagccgtcca tcagctgtat tttttctcat cagctcttca agacctggtt caaatatggg 3388561 ggaaatgccc tttctcattt catcaatctt gtgagcgtca atatcaatgc aggttacatg 3388621 atgtccaatc tcagaaagag aaacacctgt cacaagaccg acatagcctg ttccgatgac 3388681 tgttatattc attgtttccc tccaacagtt aaattgctgc tttgcagctt ccgtaatatc 3388741 gtatgagaac atcctatcat gaatgcgaat gatctcccgc atagcctgtc gggtacagcc 3388801 tgtacagatt tctgaaatgt gattcaacca tacaatacac tattatatcg ctctcaaaaa 3388861 gaaagtggtg aaatgagaat cggctgttaa aaaaaaccaa acaattttct tcttttgacc 3388921 ggctgcggag gctgtctgaa gatggtctga ttccgcagga gaagctctgc attttccgtc 3388981 agcatataag gaagttccga gccgaattct ttctctagaa cataaagagc ctcttgagtg 3389041 tgaaaatttc tcgttttcac attatgggca tctgaggcta cgaaatggat caaattggct 3389101 tcaaccagcc ggagagaaaa tgctttcagc tgcttgccga agatccccgc aagacttcct 3389161 gaagtaatct gagatgctgc tcctttttcc acaagatgat acagcaagga cgggttttcg 3389221 cgaatttccc tgttgcgttc aggatgggcg ataaccggaa tatatccttt cagctgcaaa 3389281 tcataaaaaa gctgctccgc atatcgggga acgtgatcaa acggaaactc aatcaagatg 3389341 tattttgtat cattcagcga aagcagctga cgtttggcaa ggtcttgttc cacctcgccg 3389401 tagattctga tttcctgtcc cggaagcaca tgtaaaggaa tgtcttcttt gattaaacgt 3389461 ttgtttaact gatctgctgc ttctctgact gcggctggct cgtttttata cacaccgttg 3389521 ttatgatgag gtgtcgcaat gatcgtccgg attccctgac gaacagctgc tcttgccatt 3389581 tctatgctgt cggccgaatc acctgccccg tcatccattg cgggaagaat gtgacagtga 3389641 atatcgatca tgtcctagcc cccttttttc gcaaaaataa ataacgggca cgatgcacgt 3389701 tatttatttt tgcatgaaat tgtccttggt tccgtaatat ccgtattcag agtgcttcga 3389761 aagctttttg ccgttcataa tcgccccaag gagcttgctt ttgcacgttg caagcgcctc 3389821 tttcgctttt gcggcttgtt ctttttctgt tttcccgctt gaaataacca gaacagaacc 3389881 gtctgccacg ttgcctaaaa tctgtgcatc tgctacggca agaataggcg gcgtatcaaa 3389941 aatgaccata tcatatgccg cacacgcttc gtatgcaagc tccttcatcc acttcgagga 3390001 gagaagctcg gccgggtttg gcgggatcgg gccgctcgtc agcacgtcaa gatgtttttc 3390061 attcgatgct tgtacagcct gctccataga gcttttcttt aataaaacag atgttaagcc 3390121 aaccgtattt tcaagaaaaa aagccgtatg tactgttggt tttcgcaaat cagcatcaat 3390181 caggagcact ttttttccct gttgggcgaa tacgacagcc aggttggcgg ccgttgttga 3390241 ttttccttcc cccggacaag ccgatgtaat catgactgat ttcatttgcc ggtccactga 3390301 agcaaattct atattcgtgc gaatcgtccg atattgttca gagttcaagg atttcggctc 3390361 tgtcattgca atgacatttc tctgcatccg cgagcctctg ttttttctaa gcgccaaaat 3390421 gtccactccc cgttttttca gattggaaac cctgtaaggt ctttgctgtt ttctgctcat 3390481 tcgcaatggt ggaaactgtc cctaaaacag gtatgtccag caaggattcg agctgctctt 3390541 ccgatttgat cgtattatcc aaatgctcaa gcaggaaggc cagtccgatg cttcccgcca 3390601 atccggccgc aaacgcgatg gcaatgttta gtagcggctt tggcgataca ggggacgggt 3390661 gttctgaaac ctcggctttt gacagaatgc tgacattgtc aacattcata atggatgtga 3390721 ttttgtcttg aaaaacagat gctatagtat tggcaatatg agccgctgtt tccgcgtttt 3390781 catccctgac tgatatgttg accacttggg agtcctgttc gctggatacg gtaattttgt 3390841 cattcagttc ttgggatgtc atcgacaggc ccatttcttt aatgacttca tctaagatgg 3390901 cagggctctt aatgatgaca ttgtacgtat tgattaactg aagattggtt tggacatcgt 3390961 taaattggac ttcttttcgt tcatttttcg attggttgac cagaatctga gttgaatttt 3391021 catagatggg tgtaagtgcg aagaaactaa tgagtccgcc ggcagcagtg gcagccgcgg 3391081 ttacaatcat aatcaaaagt atgcgttttg ttaacgttga taatatctct tttaagcttg 3391141 tagattctcc catgatacct ccaaatctct tataacatcc ttttccatct acgattatac 3391201 aacgttgaaa ccgcatttct ccagcttttc acgtgacata attcgacatt tttttacaat 3391261 gcgttatgtt agtacttttt atgtaagcgc tatatttact gtgttgacag tgctgtctca 3391321 ttttctctta ttcgggcagt cacgttctct cgcataaaaa aatcccgcta aaggcgtgcg 3391381 ggatttttat gttgcatatc catttttaat atgagaaatc aaattttcaa gcatttcctt 3391441 cgtcgtcatc tcagatgact gctcaccaat ttcatgtgca tgcatcaaaa ttttcagaaa 3391501 ttcttcttga ttcaatttct tttcactcat cttttttttc ctttcagctt ccattaagtt 3391561 gaaaacacga ttattatatg atgctggtta tcaatttgca atctctaata catcattcga 3391621 cacatcctat tttttatgtc cttttttagg aaaaactttt taaggccgat gtgttgcgat 3391681 ataatagaga aattggatct ttttattacg tgactcggtt aggagcgata atcatgcttc 3391741 agaatatgat ttccaaagac gatgtgctgg catctgctga acagttaaaa gaacttcttc 3391801 cttacaatga ggaaaatgtt cagctgatca aaaaagccct tattttatat cggcaggatt 3391861 cagtctatcg tttacaagca gtgagtccga cggaagttac ggcttacgtg caggatgttg 3391921 tgcctgtgcg ggtcacattg aacttgtttg tcatagtcaa aagcggctgt tcatgtccgt 3391981 ccggaagaat ctgccgccat atgctggctg tgtttttata tgtatatgca atgttcgagc 3392041 gagtgggtac ttttacagag tattggctgg agagggaaaa gcttgaggaa agcaaagagc 3392101 tcgtccgccg ccagtttcag gaaaaggtgc tgcctaatga agaatcactt tcaagctggc 3392161 ttgctttttt tgattcagag ttttctctct ggcaggcacg tacgccagaa ggcagccaaa 3392221 acatgcaggg cctctattac ggctacctgt ccgcattaaa aaaacatgcg ccgaacaagc 3392281 cggagctgaa aagcctgtat cagattcatt ccgcgattgc ggtttggctt cgcatgttca 3392341 cattgattga agcgggcaag ctaaaccccg aacaagattt ttattccctc aatccgtacg 3392401 ttgaacagct gatggataca atctacagct ctattgataa attaaaaacg tacgcgctgt 3392461 cttttgcgct tgatccgttt ttggataaaa caccggatgt tatccggcat ttgctgttga 3392521 aagaagaaat tttccaatat gaacgcatcc gcgtcttcgg tgaaatttgg agtgcgctgc 3392581 tgtcgcggcc aaaatgggtg gcacgcgaac aggagatatt gaaaaaagaa gcaggacggc 3392641 gtttttctcc cgaattgcaa ttcgggcgcc tgcatttgga attcctgcaa aaaaatgatg 3392701 acgttatttt tgaggaagcg gatcaattcc cgccggaagc gctcccttat acattccaat 3392761 ggctgagtga aatgactgcc aagaaggact ggaaacggct taaaacatgg taccagcaaa 3392821 ttgaaccaat tgcgatgggt tatacgaagc tggataagcc gtttaaagag attcgcgatg 3392881 tgatcggcga gctgttcctt ctgttgaatg cctatgtgca gcaaaccaat gatcaagcgc 3392941 tgtttgagcg ctttgccgcg ggctgtctgc cgtatacgtt cacagaatac agccatcatt 3393001 tatatgaaaa aaaacgctat gccgagtgga ttgaaattca tagccttgtc ggcttttcca 3393061 tcaatgaaat ggataaaatg atgctcaagg aaattgcagc gagcgaccct gaggcgctta 3393121 taccggctta ccatagagaa gtggcttttt tcattgatca gaagaaccgt agctcgtaca 3393181 aggaagccgc ccggtatttg aaaaaattgc gcaccctgta caaaaaagcg aaaaagcaga 3393241 aggtgtggga gcggtatatt cagctgctga gctcgcatta caagcgcctg cgtgcgcttc 3393301 aagaagaact gcagaaagga aagttgattg atggcgagtc ttaaagaaat tctcatccac 3393361 gtcgaacaaa tggaagatgg gtcatttacg ctctcagcct ttgatgagaa tgagcagcct 3393421 cttccctaca gccatatgaa aaagcatttg ttccaatggc atgaatcctc attttacgga 3393481 acctttctag aggatgtcag cttcatcggg acgactgctg tccttctatc tccatggatg 3393541 actgtagagc ttctcggcaa aaactcgttc aactcattca gctccgtgca gcttacagaa 3393601 gaaacggagc cgctgatcga ggcggcatcg accatctatg aatttatcgc ggacggcgat 3393661 tttatgcctg actatgacgc atggacaaac ggtgtttttc gctggaagga ccgcgataat 3393721 atactggaag gctttactgc ggaatggttt tccgctgccg tacaggatta catccagtac 3393781 gacgatgacc tgcgggagaa atgggaacat atcaaggaaa aatcgcctgc ggttacgaca 3393841 ttccgtggcc attttcttga tgaagaggat tttctggaag gcattggctg gattgacgat 3393901 caatctccat ttactgtcgg cttgcgctta aatgaaccgg actttgacgg agacgaatgg 3393961 aagatcgaga tgtttttacg cgataaaaag agcggtgctg tagaattctt tgacggactg 3394021 aagagcctca aaaaatcgtg gcaggcgtac agcgataaaa tcgcgcgtga gcaggaccgc 3394081 tttcacagaa cggttccgtg gctgtcgttt gattccggga caacgctgat ctcggaggaa 3394141 gaagcctgga tcttcctgtc agaagcaagt gagacgcttg tcgatatggg ggtagaaatc 3394201 ctcctgccgt cctggtggca gattgtcaga gacagcaaca tgatgctgaa agcaaaggtg 3394261 tcttcctccc cgcgcggcga gtcatttgtc ggcatgaatg cactgcttga tttcaactgg 3394321 cggtttgcga caaatggaat tgaactgact gaggctgaat ttaatgagct tgtcgccagc 3394381 aacaggcgcc ttgttaatat ccgcgggcaa tgggttaaaa tcgatccgca gtttatcaaa 3394441 cagatgaaac gcctgatgga aaaagcagaa tcagagggac tccacatgtc tgatattctg 3394501 gcgcgggagc taatggatca gcaggatggc ggacttgagg attcggacct gattgataca 3394561 tctgcttttg ccggcattca gtttgatctg tctaaacagc tcaggtcact gattcgaaag 3394621 ctcactgccg cggaaaacct gccggagcac aaagtcagtc cttctttcaa aggaacgctc 3394681 cgcccttatc agaaatacgg catgaactgg ctgctgtttc tgcgggaaag cggttttggc 3394741 gcctgtctgg ctgacgatat ggggcttggg aaaacgattc aaatgatcgc ctatttcctt 3394801 cacgtgaagg aaagcggccg acaaaaaacg cctcatttga ttattgcgcc gacatccgta 3394861 cttggcaact ggcagcggga gcttcaaacc tttgcccctg atctgtctgt cgcgctccat 3394921 tatgggccgc gccggccaaa gggtgatgat ttcgccgcgc attatgaaaa cgcagacgtg 3394981 gtgctcactt catacggtct gtcacatgcc gatactgaag agctttcttc tgtgacatgg 3395041 aacacgatct gccttgatga agcgcaaaat attaaaaacg cgcatacgaa gcaatcacgc 3395101 gcaatcagga agctgaaggg gcttcaccat atcgcgctga gcggcacgcc gatggaaaac 3395161 cgactgactg agctgtggtc tatttttgac ttcatgaata aaggctacct cggcagtttg 3395221 accggcttcc ataaacgcta tgtgctgccg atcgaaaaag accgggacga aaagagaatc 3395281 ggacagcttc agcaattaat ccggccattc cttctccgcc ggacgaaacg ggatgaagag 3395341 gtcgcgctta atcttcctga gaagctggaa gaaaaagaat ttatccctct gtcagccgag 3395401 caggcatccc tttatgagca gctcgtcaaa gacacttttg accatatgac atccctgacc 3395461 ggcatgcagc gaaaagcgct gatcctcagc atgcttggac ggctcaagca aatatgcgat 3395521 catcccgcgc tttatttaaa ggaagagcaa accgagctgc tggccggcag atcagtcaag 3395581 ctcgaaaaat tgctggaact gatgacagcg atccgcgccc aaaacgaaag ctgcctgatt 3395641 ttcacgcaat acattcagat ggggaacatg atgaagcggc tgcttgaaaa aacgttcggg 3395701 gaacctgtgc aatttttaaa tgggagtctc tccaagcaag agcgggatac actcgttgag 3395761 aaatttcaaa ggaaagaata tccgacactg attctttcac tcaaagctgg aggcaccgga 3395821 cttaatttga ccgccgccaa tcacgtcatc cattatgaca gatggtggaa cccggcggtt 3395881 gaaaatcaag cgactgaccg tgcataccgc ataggccagg agcgctttgt ccacgttcat 3395941 aaaatgatta cgacaggaac aatcgaagaa aaaattgatg tcatgcttga atccaagcaa 3396001 accctgaacg atcaaattat ccaaagtgaa aactggatta ccgagctttc cacacaggag 3396061 ctcgaagaat tgtttacatt aagcgctaca gcgcaataat catgactaaa aaagctggct 3396121 ctaaaagagc cagctttttt ccgttcatag ccgtcacgcc gaatttccaa aaaatccgtt 3396181 acgccggtta tcaacagggt gcgcttttgt ggcagcacat atacttacaa caaatgtttc 3396241 atcatatgtg cgacaccgtg ttcgtcattg gttaaggtga cagcatcggc tatcgatttg 3396301 atgtcttccc gggcattgcc catcgctaca ccttttcccg cagcctccag catcgatttg 3396361 tcatttaaac tgtcacctac agcagcagtt tcctcgagcg gaatattcag ctgttttgca 3396421 agcctcttca gcgcctgccc cttggaagct ttgcgggaag aaagctcaaa gttgtgctca 3396481 gccgaactga caagcgtcaa atcttcggca tgctcatatc ttttccagcc tgcctcaagc 3396541 ttttctttga agaaagaaaa gccgagaata ttgtaaaaat cgattggctc atcggcttca 3396601 aacagctctt gaaaggagtt aatgtaagca aagcccgatt ggctgtattg cacctcggcc 3396661 gcctgcttaa ggacagaaag atccgcttcc ggatttgcgc ttctgaatct gtcgagctca 3396721 acatcaagaa gttctctgcc gttttgcggc gtataaatcg ctgaacctgt gaatacctca 3396781 taataatagt tttccgactc aagccatgag agaatgtcat acgcccgttt cttatcaatc 3396841 gtttcgtgat gataaagcct gccctcggga tcgtgaatga cggcgccgtt tgcactgatg 3396901 acccatgttt tgatccccag cggttcaaag attgacatga cgtcaaaatg agcgcgccca 3396961 gttgacacca ccacttcaat gccgtcccgc tgcgcctgcc gcagtgcgtt ttcattttcc 3397021 aagcttacct gatgcttgct gttgagtaag gttccatcta agtcaatcgc aattaatttc 3397081 acgtttgtca gtcctttcct tcatcctgct ctgtcacgag aagctcaacg ccgtttcggt 3397141 caagcaagtc acaaaatgcc tgattcggca gcctgtctgt aatcaagagg tcgatttcat 3397201 tcagctccgc atactgataa aaactggtgc tgcccagctt agaatggtct gcaagcgcaa 3397261 ttacctgctt tgcctgctgt atcattttcc gcttcaccat gccatcctct tcatgcgcaa 3397321 ttgtaatgcc atgttcggaa atgccgacca caccaatcag cgctttatca acatggtagc 3397381 ttgagagctt ttcaatcaca gaggacccgt acagaaagcg gtgctccttt tccagcttgc 3397441 ctcccagcag ataaatttca attccctctt tatcggacag cacatccgca agattaatcg 3397501 aattggtgat tacggtacaa tcaaccgcat tcaaatgctt tgcacatgcc tgaacagttg 3397561 tagaggcgtc taaaatcacc cggtctccat catgaataag cgatgctgca agcctgccga 3397621 tcttattttt ttcctcagac actgttttca ggcggccgga atagctttga attttctgat 3397681 gcacagtcgg taaaatggcg ccgcctcttg tgcggatgat ggcattctgt tcctcaagtt 3397741 tcacaagatc tcgtcgcgct gtatcccttg acacttgcag gagcgtacag atctgctccg 3397801 ttgtaattcg gttatgctgt tttaaaaaat ccaaaatcgc tactaatctt tcttcttggt 3397861 acacgccctc attccttttc tcagcaatca tttataagta attataagtt tttatttgat 3397921 tttattcaac attaataagt gattttaagt aaaaatgcgt cgagagaacc aatttttcct 3397981 aagtaggcaa aaagaaagaa ccagtctggt cgactggtca attttgaggg gatgatgcga 3398041 agatccggat aatagtgaat ggatagataa cgggaggagc aggggtgtca atcagcagct 3398101 ttttcccggg gtttagggtc cataaaacga acagtgtcag ccaacacttc tgttacatac 3398161 acgttaacgc cttcctcgtt ttcatagctt cttgtctgaa tccgtccgct tacgccgacg 3398221 agagaacctt tttggcaata caacgccgtg ttttcagctg tttttctcca aagtgtgcaa 3398281 ttgacgtaat cagcttcgat ttcacctgaa gcattcttga agctgcggtt caccgcgagc 3398341 gtaacatgtg caactgccgc accggcggaa gtgtagcgaa gatcaggatc ttttgtaaga 3398401 cgtccgacaa gcatgacctg attgaacatg cgattcctcc tctccttgcg gttgtatgta 3398461 ttgtaaatga tgcaacaaga aaagaaaaac gcttaaaaat ggctttcagc ctctgttttt 3398521 atctttcgtt ttcatttttc cttcagctaa aaacatcttt tgcttttttc ctttgaagaa 3398581 atatgtactt tttaaaaaac ggaaaaagat ttgctttgtc agccagtttt gcgtattcat 3398641 gcgcacatag gaagagccat cccacgcaaa ccactgaaag ctcaattttt tttccggcat 3398701 tgacagcttg attttatact gctccatgcc atcttgtgtt tcgtataaaa aacttattct 3398761 tccttttttg ttcagatgaa cctcaaacac ttctttacgg cttaacatat atgttacttc 3398821 cttttgaatc aaatgacttt cagaaggaac gccgtcaata taaatttctt ttaaacgaaa 3398881 ttgattcata ccacatctct ccgtaatcca tagtcagtta cagtataatg aaaaaataga 3398941 aattattaaa tgtttcgctc atacaaaatt ctttagcccc aacattgcag gattttttcc 3399001 tcgaaaacgt ttatgttata atggaaggca agaaaacttt ggaagtaatc ggggtgagaa 3399061 gaaatgaaaa cctttaaact ggttgacctg aatgtggaac gagtggacaa ggaagaacaa 3399121 tcaattgaac agtttcccct tattgacgga ctgattataa ataaagaaga cggtgaaaat 3399181 cactggctga ttgaggcgct tgtacagaaa gaacatctgt ctttttttga acagcttcaa 3399241 aacagccaat ctgaagccaa agtatttgta acgatcacga aaaaaagcaa tcgccccgcc 3399301 cagctgacag cagcagtgaa aaatatcgtc aagctggaag aaagcattca ggttttactc 3399361 tacggacaaa tggtcacaag aaaacagcag ggcactgaaa ccattctcga gtcccttgta 3399421 aaagagggct atacaggaac aaaactcatt gaggcattta agcaaaaatt ataaatatga 3399481 gggggcatgt tccccaaaac agactcagaa ccgaagagca tcacaataga catttagaat 3399541 agatatgttc tgcatgaaaa aagctgccgt tttgaacggc agcttttctc ttcgtgcttt 3399601 cactcttgca tatttaattt gtatggccaa aagaatcaac caattcccct ttcacaacga 3399661 ggcgcccttc ggttttgacc gccttgtcac atgtgattaa cgtaatctcc tttttgtttg 3399721 tctcctcaac tacatctgca tccatttccg atatgatgtc tttcgatgtt acagaataga 3399781 tataatcctt tttaaaatcc gtgatgacaa tttgggcacc tgtttttatg ttttccagag 3399841 gtccgaacag aagattcttt tgcttcaaat gatggcccgc caacggataa tttccctcac 3399901 ccattttttg atcccggcgc attgttgccg cccctatcaa aagattttca ttggttgtgc 3399961 cttttacgat cggaagctcc agatcgacac ttttaattgt tatccgccgc cttgattgtg 3400021 aagtaaaaat aagtatattt cacgtgcttt cgacgttctc cacttgactg gaatgcttta 3400081 atggcgatcc cggcatctgt agcttcaggc tttccttcag aggaatcaga aatctcaaac 3400141 tctattttct cagtgttcag cacataaccg gctggcgctt tcgtttcaac aaaagcgtat 3400201 tgtcccggtg caaggcctga agctgtgact tgatgatgcc ggatatgact ggtttcgaag 3400261 tctgtatgaa aattcgcgaa cgattcagca tggttgatct tccggttctg atcattacag 3400321 ctgccattat cggccatgac aaatacaagg cttttcatgc cggagcgaat gacattttgc 3400381 aaaaacccta tcattactct gaatttatgg cgcgtattca aaacctgata atgatgaaac 3400441 atacagcaaa tcaagccaca agaatggaaa tggcgtttct ccagtcgcaa atcaagcctc 3400501 attttcttta taatgtatta aacacgatta tttctctcac tcatttggat attgaaaagg 3400561 cccgggaggt aacagaggaa tttaccaact atttaagaat gagttttgac tttcaaaata 3400621 catcagccat cagttccttc agacatgagc tttcgattat caattcctat ctttctatag 3400681 aaaagacgcg attcagtaat cggcttgagg ttcttttcga tatagatgaa gacattgact 3400741 ttatccttcc gcctttaatg attcagccct tggtggaaaa tgccgttctt cacggtgtca 3400801 gcaagaaaag aggcggagga tggatcaaac tgacagctaa aaaacaaagc aaaaatgagt 3400861 atcacatcaa agtagaggat aacggtcccg ggataactcc ggaaaaacaa atagatctct 3400921 tatcaacgga ttttgatcgc agcgtcggat tgaaaaatat caatcagcgg ctgaaacatt 3400981 tttgcggaag cgagttgatg atcagcagca ctccggatgc aggcacctct gtctcaatgc 3401041 tcattcatct cgctgaaaca acaggaagcc ctaaagaact gaaggacaca gaacgaacct 3401101 aaacgaaaat tgagataaaa aaagacgccg tttctaacgg catctttttt attccggcga 3401161 ctttgcttgc tgcttcagca ggtctctgat ttctttcagc agctcctcct gcgcatccac 3401221 cgcttcctcc gcagcctctt cttctgcttc ttttttgcgc cttaacccat tcaaagtccg 3401281 aatgacgata aaaatggaga acgatataat taagaagttc acaatcgtct gtataaagct 3401341 gccatatttc actacagcat cgccaaacgt aaacgacagg cctgaaaagt caagccctcc 3401401 cagcagcaaa ccgaccaaag gcataatgat atcatttact agagatgtga cgatctttcc 3401461 gaaagcgccg cctatcacaa caccaatcgc aaggtctacg atattccccc gcatggcaaa 3401521 ggctttaaat tcattccaca tacaatcacc tgcttttcta tatttgtaaa gaaaaaaaga 3401581 caaatgtgcc gctggccatc tgcctttttt caattattct ccgagggcaa aagtcagttc 3401641 tacttcgcaa acgacttcgc catcaactgt ggcaacgcct tttccgcgcc cgattgtgcc 3401701 gcgggcacga atgatttcaa cctcaaggtg aagctggtca ccaggcttga cttgtttttt 3401761 aaagcggcag ttatcaatgc ctgcaaaaaa agccagtctg ccgcggtttt cttctttaat 3401821 caacatcgca acagctccga cttgagcgag tgcttctacg attaatacgc cgggcataac 3401881 cgggtactga ggaaaatgtc cgttaaagaa ctcttcatta gcggttacat ttttatagcc 3401941 ttttgcccgt ttgccctctt caacttccgt aatccgatcc acaagcaaaa acggataacg 3402001 gtgaggaata atttctttaa tttgctgagt atcaagcatt gtcttgacat ctccttcatc 3402061 tgcattagta tgtatagcaa tcatcaaaga tccaatctgt acatttgaaa agtatattat 3402121 gaattaatct ctttttcaac cgcgctaaaa tgtaaccaac tgtcaatgag agccgtcaaa 3402181 agttatgata tgataattat agattttacc aatagcaaag aggtaggaaa atgatttcga 3402241 agtttattga aaaaagaatg ctaaacatgt tagacgagtg gtattccgca atgagcaaac 3402301 gcaaaatgaa tcacgtttgc acactgaaag agaaaattga tcagcacctt ccaaagatca 3402361 aaaagaacac aaaactttgg atgcgttatc aattgtttca ggcccgccat cagctgcttt 3402421 ttgaaaacca gaacggactc gattcattgt tcgatggcct atatggcctg gaagacaaaa 3402481 tggatgatga attgaaatat tatctgtatt ttttctctgg gttatatgag atggtaaaaa 3402541 cagctccgaa acatgcagta catcatttta aaaaagctga acagtacctg gccgccattc 3402601 acaatacgtt tgaagccgct gatttatatt atcaaaccgc cggcgcctat tacttgatga 3402661 aatcaccgcc gctttccgtc caatacgtca aaaaagcatt acacatctat ttgcaccaat 3402721 tcggctatat caaaaaggta atcacctgta aacttttgct cgccgtgaat tatattgatc 3402781 aagaacgcta tgaaaaagct gaacagcttt tcaaagaaat cattaagaaa acccagcaac 3402841 tacatgacga aaacctgcta tgccacgctt attataacct tggcttttta aaagcgaccg 3402901 agaaaaaaga ccaggaagcg cttctttact ttagaaaagt attaaagaat caagaatttg 3402961 aaatgaattc accagtctca tatcttcatt gtgtgtacga gtctgtcaga gcgcttttta 3403021 aaacagggaa catcacagaa gctaaagccg tccttcaaaa aggaaaagaa ttatctgaaa 3403081 aggtagacat tcaaaccatt tatttaaaat taaaaacgct tgaagccctc tacacatcag 3403141 ccgaagaccc ttatgagcag ctgctcgaat atgtgcttga attagaaaaa atcgaggcgt 3403201 gggtggattt agaagtgctg ttagaagata ttacggaata ctacaaaaaa aaggacgatt 3403261 tcgaaaaagc cgcttttttt atcatgcgcg gctgattgaa aaacgcccat tttcttatta 3403321 tctgactgaa ttgattaaac cgagcatttg atctcccatt gtgatcgttc tgctgttcag 3403381 ctgatatgaa cgctgggacg tgatcaaatc tgtcatttgt tctgaaatat cgacattgga 3403441 catctcaagt gagccctgct gcatgccgat gttttgtcta ttagcgccgt tcagctcttc 3403501 aaaagctgcc gcattatcaa tagagaaaag gttattccct tcggatttca gctcttgagg 3403561 gttattcact tggacaacgc caagattaaa ccgctgaacc gcgtttccgt cagatgcggt 3403621 taaggtgccg ttcttattaa tggtgatatt cttcattgag ctgtcgatgt tcactgtatt 3403681 gccgttctca tcaagtacgg gatacccatt tccagtgacg agctgcagct ggttggcatt 3403741 cgcagcggac ggcgttacat acagcgcccc gtccctcgta tactggcggt ttccatttac 3403801 atttacctga agatactggt atggagacgt aaatgcgata tccagatcgc gatcggtctt 3403861 ctgaatgctt ccttgatcag agactaggcg tgaactcatc atcgctccga cgccaaggcg 3403921 caagccgggc ggcgtttttc gggcttttgc cacttcctcg tttttttcat caacctgatc 3403981 gaattgctgt ctgacaagct cagaaaaatt cgtatctttt gccttatagc cggttgtgtt 3404041 gctgtttgaa aggttgctgc tgattgtgtc aatctgctgc tgcagctggt ttaaggttgt 3404101 tgatgccgtt agcattgacc tgagcatagt tgatgtcccc cgtttttttc ttccgttttc 3404161 ttaaattttt ccaatttcat ttgctgcttt atccatactt ttatcgtaag cctgaataac 3404221 cttctgattc gcctcaaacg atctgtacgc ttcagtcatt tctgtatagg cgcttgtcac 3404281 atccacgttt gaaagctctg agacgccttg ttttaatgaa taggctacct gattatttcc 3404341 ggctgcgctt ggcagatcat taccgtccgc cgtgctgtac aaatcatttc cgtcccgttt 3404401 gagattgcgg acatcttccg ccattctgac atcaatctgg ccggctgtgc gtccgttcgt 3404461 tgtcacagta ccgttttcag acacagtgaa attctcatta tcaacagtga ttggctggcg 3404521 atccgtcgat aaaatagggc gtccgttgat cgtcagctga ttgttctcat ttagtgaaaa 3404581 tgtgctgctt tttgaataac ggattccatc cgctgtttga accggataaa aaagagcagc 3404641 tttttcattg gtttccgcac tcatcggaac ttgattttcg atcaatgcaa tgtctgtagg 3404701 ctggtctgtg gacttcaggc ttccctgtgt aaagagaggc ttgagctcct gcatatatac 3404761 tccggtattc acggaaccga tttccgtcct tgatgtcccg gccggagatt ttgattctat 3404821 tctgctgagc agcatctcag ggaacgcgcg catagagcct tgatcagctt tatatcctga 3404881 tgtatttgcg ttagcaatat tatttgaaag catttccgtt cttcgctgct gggcaatcat 3404941 tgcggatgtt gctgtatata atccttttaa caaatttccc acctctaaaa atggcatttt 3405001 ttccagttgt catataggaa cgttcgttct ataataaaaa ctcagtattt tatcctatta 3405061 tcgtcattta acatcttttc gtgaaggctt tttcataaaa aaacctcatt ctttttcaga 3405121 atgaggtttg tgaaatcagc ttagtttgcg tttaggaagc ttgtccatat tatcaagcat 3405181 gacacctgtg ccgatggcta cgcaatccat aggattttca gcaacgagga ccggtacctt 3405241 cagctcttca gcaagcagct ggtcaaggcc gtttaagagc gcgcctccgc cggtaataat 3405301 aacgccgcgg tcaataatat cagcagaaag ttcaggcggt gttctttcga gcacttgttt 3405361 tgcagcctga acaataacag cgacagattc acgaagggct tcttcaactt ctttactgtt 3405421 tactgtaatt gttcttggaa gaccggaaac catgtcccgt ccgcgaatgg aaatttcctc 3405481 gtgacgtgcg tctgggaaaa cagttgcgac tttaatctta atatcctccg cagtacgttc 3405541 gccgatcagc agcttgtact cgcgtttgat ataatttaag atttccatgt caaacttgtc 3405601 cccagccatt ttaatagaag aggaggtgac aatatcgccc attgaaataa ccgcgatatc 3405661 cgtcgtcccg cctccgatgt ctacaaccat gttaccgctt ggctggaata tttccatacc 3405721 cgcgccgata gcggcaactt taggttcttc ttcaaggtac acatgtttcc cgccgctttt 3405781 ttctgcagct tctttaattg ctttttgctc aacggatgta atattcgtcg ggcagcaaat 3405841 gagcatgcgc ggctttgaga acaggccttt tacattcagc ttgttaataa aatgtttcag 3405901 cattgcttct gttacttcaa agtcagcaat aactccgtct ttcagcgggc gaatcgcaac 3405961 aatattccca ggtgtacgtc caaccattcg tcttgcctct tcgccaaccg ccagcacttt 3406021 gccgctgttt ttatcaagtg caacaacgga aggttcattc agaacaattc ctttaccttt 3406081 aacatggatc agtacatttg cagtaccgag gtcaatacca atatcccttg caaacatcta 3406141 tttatatcct ccttgaaaat ctgtttcaca gtaaatatcc acattgtgcc ctaattatat 3406201 atattatcat aaaatataga aaaaaagttg gaagcacaat aagttcttta caaatttttg 3406261 cggatgtttt atgaacgatt tcaagaaggc aatgccaggt gattacgatt gctgaacagg 3406321 ctctccttcg agaatttcat cttttttata tttgagcttt gtcgcttctc ctcctcttaa 3406381 atgcctgatg gatttatgat aatcgagtat ttctttcact tcgtttgcca agtcggggtt 3406441 aatttcaggc agacgctctg ttaaatcctt gtgtactgta cttttggaaa caccaaattc 3406501 cttcgcaatg acacgaacgg ttttctttgt ctccacgatg tacttcccta tcttgattgt 3406561 tcgctctttg atgtaatcgt gcacaccact cgacctccct aaaatggatg tgagaagtgt 3406621 gaaatgagat ccgtattctg taaagagtcg ttcattatgc cgcttcttcg ttgtatggtt 3406681 ttaaaagtaa gtttgtgaaa tatgcccacg atccctcacc tcaaacactc tctttgttag 3406741 gtttgtaaca gtgtattagc attcttttgg gaatatgcta aaaactcaat aaggacaagg 3406801 ggtgaaacga actttttcag attcagcaaa ctatttcgcg tcactaaatt ttcatcttta 3406861 caactattga tcgctcctgt aaaatgaaat aagcaattag ttacttaggt aagtttttta 3406921 gaaggagacc gacatgtcct acgtcaacag acacctcatt catcaaatca accaaagcgc 3406981 ccgcctgatt gccaagaaag ccaatgaaca gctagagcca ttcggccttt attcatctca 3407041 atggtcagtt ttatattgtt tgcgtacgat cggaccaatg actcaaaaag agatttggtc 3407101 ctatttaaat gtggaagcgc cgactgtgac tcggacgatc aaacgcctgg aggagaacgg 3407161 ctgggttcag agacggcaag gtgaagacaa acgggaaaaa cttgttgtcc tcacaaaaga 3407221 agccgagaaa aaatacgaag aaatcaatgt gaaaatgttg aaattcgagg aagagctgct 3407281 tgcagatttc cgggatgaag ataaagaagc tttttctcat ttattccgca tgtttttaca 3407341 acaatgaaaa taaggaagtg acatacattt gaaaaaagcg gatgcgatat ggaccaagga 3407401 ttttattatg gtcctgcttg tcaatttatt tgtgtttgtg ttcttttata catttttaac 3407461 tgtattgccg atctatacac tgcaagagct tggcggcaca gaatcacaag gcgggctttt 3407521 aatcagcctg ttccttctgt ctgcgatcat tacacggcct ttctccggag ccatcgttga 3407581 gcgtttcggg aagaaaagaa tggcgattgt atcaatggcg ctcttcgccc tatcatcttt 3407641 tctgtatatg ccgattcata acttttccct gctgctcgga ttgcggttct tccaagggat 3407701 ttggttcagc attttaacga ctgttacagg tgcaattgcc gctgatatta ttccagccaa 3407761 acggcgcggt gaagggcttg gatactttgc catgtctatg aacctcgcta tggcgatcgg 3407821 gcctttcctt ggcctgaatt tgatgagagt ggtaagcttt cctgtattct ttacagcctt 3407881 tgcgctgttt atggttgcgg gcttacttgt ttcgttcttg ataaaagtgc cgcaaagtaa 3407941 ggacagcggc acgactgtat tccgttttgc gttctcggat atgtttgaaa agggcgcact 3408001 caaaattgcg acggtcggtt tgtttatttc tttctgttat tcaacagtca catcatatct 3408061 gtctgtattc gccaaatcag ttgacctttc ggatatcagc ggatatttct ttgtttgttt 3408121 tgcggtgaca atgatgattg cacgcccgtt cacagggaaa ttgttcgaca aagtcggacc 3408181 gggcattgtc atttatccat caatcctgat tttctctgtc ggactctgca tgctgtcctt 3408241 cacacatagc ggcttaatgc ttctgctttc aggggcggtt atcggtcttg gctacggatc 3408301 aatcgttcct tgcatgcaaa cattggcgat tcagaaatct ccggctcacc gctccggttt 3408361 tgcgacggca acgttcttta ccttctttga cagcggaatt gctgtaggat cgtatgtatt 3408421 cggattgttt gtagcatctg ccggcttctc tgccatttat ttaacagcgg ggctgttcgt 3408481 tttaattgct ctgcttctct acacgtggag ccagaaaaaa cctgcagagg ctgaaggaaa 3408541 agtgtctatt gcagaataac ttgtcagact gccgggaaat cccggcagtc ttttttccat 3408601 taaaacacgg cgccctctcg gttgaacgag agaacgccgc ttatagcaat tattcaatga 3408661 caggccgcgc aggtgaatca ggatctaacg aaaaatcata ggacgcttca tcacgaaaca 3408721 tcggatcggc atatatggat tgttgatcgt tttttgttgc ttttcgatac gaagaaaatg 3408781 aatcatattc tttctttttc cacatccata tgccgtcttg atccgcttcc ttgtggtaca 3408841 cgttatgatt gaccgtatta ccttcgtttt ctgtaaagtc gtttccgata aataatctgg 3408901 aatcaccggc cgtcaatata ttcttttcaa ttgtgttgtt tttcgtatcg tactgcagca 3408961 gcagctgtcc gccgtacagt ccctttgtgt cattccggta cataatattg cgggcaatca 3409021 gagaattgct ggtgccgccc cgctttttgt catatcctcc gattgaaata ccggtgtacg 3409081 cattgttgta cactttgttg tctgtgatct gaatggcatt tgcatacttt cctttgtgtt 3409141 cagacgttgc ttcaatccca atatcgttat cgtaaactgt gttgttctta atttcgatat 3409201 cgtgtcctcc atcgacataa atcccgcccg ctgagtattc atctccataa gcaggattgc 3409261 cgtaagtcga gttttgataa actgtattgt tttctacgac tccgtttcgc acgtaatcgt 3409321 ttttatccgc ggttccctca taaccaatta gatcaatccc gatgttatta ttgttgcgga 3409381 ccacattgcc tgcaactgtg aagccgtcga tattaccgtt cagcacaact gcttcactcg 3409441 ctccaagcgt cagtttctca actgtattgt cctcgattcg gatgtctttc atgctgccag 3409501 tcccataaac tgcgattccg tgagcatttc cttcatccgc tgttgtctta atcccccgga 3409561 tgtgattatc cttaatggcg atatgactgc tggaccctga tacataaatc cctatagcag 3409621 ttgcttcctc agatgaaaca gaaagatctt gaattgttaa accgctgatg gcaatgtcat 3409681 gtttatcgtg aatacgaata agcggtgttt catattcagc gttcgcaacg gattcaccgc 3409741 taatcacgac gttttcattt tcatagtttc ggaatgtgat aggctttccg tccgtaccgc 3409801 tgtgctttac atcaagggtc tcatgatacg tgccctcccg aatcatgaca gttgtgccgg 3409861 cagcagcctt ctcagatgcg tgtgccaatg tacgaaacgg cttttctttt gttccttcat 3409921 tttgatcact gccatttggc gaaacataca gataatcccc agatccttcc tcattcgctt 3409981 ttgtcttatc ataaacgaaa gcgaggatga cagacgttaa aacacccgcc aaaagaataa 3410041 aataccattt tctcattttc gattcccatt tcgttttaga atagatttct aaaaccatta 3410101 taaatgttct atttatggaa aaccatttca aaaatatgaa aatataccgt ctaaatagat 3410161 cttattcagc ctggcggacc tgcgcatgtt caactgtttc aattgccaat gatgcaggcg 3410221 ggtgaacacg catcagaaca atgtagaaaa gaaaggaaat cagcacacct acaaaccaag 3410281 aaatatcgta taagctcttc aatacaggaa catacatgcc aatcagcgaa atcagcgctc 3410341 ctaacattgt ggctgcaaac gcacggtaat tgtagccctt ccaatacaca taccgtcctg 3410401 tttcggaata caggtcatct accgagagct cacgtttgcg aatgataaaa tagtcggcca 3410461 tcatcacgcc tgccaccggt ccaagcatgc cgcctattaa gccaagaaac gcatacacgc 3410521 ttgtcgcgct ctccatcagc ttccacggaa ccgtaaataa agcgagcaac gctgtgataa 3410581 agctgccacg tttgaaattg atatatttcg gcagggcatt cgctatatca taagcgggtg 3410641 atacgatatt cgccgcgaca tttacagaga tcgtggcgat gcagagtgtg atcacggaca 3410701 agacgatgac ataagggtta tcaaaccgcg ccaaaatatc gacaacatcc caaatcggct 3410761 ctccgaacgc gacctgcgag ccggaggtca ccgtaatact tgcgaatgcg aacagcgcaa 3410821 acgttcccgg caaaccgtaa aattgtcctt tgatttgctc tttttgtgtt tcagcaaacc 3410881 gtgtaaaatc aggtatattt aagatcaatg tcgcccagat gccgatgatg ccagtaactc 3410941 cggcagcaaa cggccagaat gtttctgaaa acgtatgaaa ctttcctggt tgagagtata 3411001 tcgggcccaa tcctccagca atatcaacgg cccaccatac catgccgcca aataccagat 3411061 acactaaagg ccctgcccac acctcaaaac gtttaatcga ctccatgccg tgatgcaata 3411121 cgagtaaatg aatggcccaa aagaatacaa aggaaagcaa accggacaag tgaatgccga 3411181 gaatgttcca ctcgccgcca atttctcccc aacctggcca catattcaaa agcaaaatgt 3411241 tcagtgccgt gctacccgca aaggtctgga tgccaagcca catgatagct gtaaacgccc 3411301 ttagaagcgc ggggatattc gcgccgtata tcccgtaaga agcccgaatg atcactggaa 3411361 acggcagccc gtattttgtc cccgcatggc cgtttaaggc aagagcgcca aataggataa 3411421 gtgatgccgt aataatgatc gccagcacct gccaaggcga aaggccgatc gcaattaatc 3411481 ctcccacggt cgcgtaggtc ggtatgttat gtatacatcc catccaaatg gaggcaaagt 3411541 tcattgcttt ccacgtccgt ttttcctgtc ccaaaggcac cagatcttca ttgctcagcc 3411601 tgttggattg ctgctgactc tcttttaatt tcatagccgg ctcccctttc catattgtct 3411661 atatgtcgtc acacgttatg ttttttgaca ttagatgtca cttaatataa ctgaagagtc 3411721 agacaataac actggctatg atatacaatt ttcccgtttg tatttgaaca gcttaaacaa 3411781 gaaaaagaga cagacctcag agcccgtctc tttcttaaga tgcagttttc attaatgcag 3411841 caaatctcac agccattaac aggcttgctc cgcccgctat aatcataatg attcccatca 3411901 tatcaaaatg ggctgccgtg atttctttac caaaaagaat gccaaggatc accgaagaca 3411961 aaatcgatcc taggtaacgg caggtttgaa acaggcctga agtcgttcct accatgttgg 3412021 aaggactcgt ttccagcatc gctgcctgaa gcgcgacatt gcccagtccg tagcctatac 3412081 ccaagagcga cagaatgagg cctttaccga tggtctggac attgataaaa aagatggtta 3412141 agagcacggc tccagccgtc atcaaaagcg ctcccgcaaa gatcggcttg acgacaccag 3412201 atcggtcgat ccatttgccg gttagaggtg acacaacgat gctcattcca gacataaaca 3412261 gcataaacag gccgctcgtt tgaacagaaa gatgcatttc atcctgaaag taacttggca 3412321 aaccaaaaaa taaacaatag aagaaaacat tcaataaaat aaactgaaca tacacggctg 3412381 acaggtttcg ctgtgtttta aacagacgga catcaataaa cggcttatcc gttttcagct 3412441 cgcgccagac aaacgcacag agcagaagca agccaagcac accttcaacc gcatgcggcg 3412501 acgtgctgaa cgacagcaaa aaggatagaa ggaaaatgat tcccccggca aataaaacaa 3412561 ttccaagaat atcgagctgc cgaataatgg ttttgattcc tgcccctttt ttctgatctt 3412621 tcgggaacat atacaggccc aataagaagc tgaggataat aaacggcaaa ttaacgataa 3412681 agatcgccgg ccagcctccc catacaatca aaaacccgcc ggctgtcggc cccagcgccg 3412741 tcatggcgga cgcaaaaata gagagtacag ccaaggctga agcttggcgc tcatgaatat 3412801 gattccgaat caagccgaca cctgacggat aaatcgcact gctccccacc gattgaaaca 3412861 gccgcatgac caataatgtc ataaacgtcg gcgcaaacgg cgccccgatg gcagaaaccg 3412921 caacaagaat aagcccgaat aaaaacaagc gtttccgccc aatcaaatca ccgagctttc 3412981 ccgttacggg ctgcgctacg gcactcgcca agtaaaacga ggaaatcagc caggaaaccg 3413041 ttgtaaacga gaggtgaaac tcatgctgga tgctatggag cgcaagagag atcatagacg 3413101 agttcagcgg attcagcatt gttcccgaag ccacagctgt taaaaaaaca gctcggcttt 3413161 ttttcgataa catcatttca cttgttccag aaactcttcc gttgtccgcg atttaccgat 3413221 tctcgggaaa ataaagcgca gtgtggcttc atgctcttca tcgctaaatg tggacatggc 3413281 atctgtaata aaaatctgct gatagccaag ctgaaatgcc tcccgtgctg tgctttccac 3413341 cccgatattc gttgcgatgc cgcacaatac aatcgtatca atgccgcgac gtctcagctg 3413401 caagtctaaa tctgtgccaa aaaaagcacc ccattgccgt tttgtcacag tataatcgcc 3413461 atcctgcaca ccgatttccg gaacaaattc ggcccagtcc gccggcattt cccctgaacc 3413521 tccctgcgca ggctcatccg tttgcggctt cagggcgtcc gctccatcat gaaaggctac 3413581 atttacaaag ctgatgaacc cgttatgttt ccgaaattca tctacgagct ttttcgcgtt 3413641 cgggacaacc tggccgcttt gatcaatcgg cacaattccc ttttgtaaat caatgataac 3413701 caatgctgtt ttttgaaaat caatgttgag tgtattcatc atacgtctcc tcctgatact 3413761 gttagtgttt ctcacattgc atattttact cttcacactg cctaagttct tttatgatgc 3413821 ttgtgaaatt ctcagaagga gcgttttctc atgatttttc ttttatgtag tagtaacagg 3413881 ttgtgcatac gaacaaaccg gcaagcactg taatcataaa gggcgtcatc gcttcatcac 3413941 ctgcctgctg tctatcggtt cctgcctgaa aatgcccatg aatttgcggc ggtccatcca 3414001 aagcaggata agacacataa ccattaatat cgtgctaaga tcctgcacgc caatatcaaa 3414061 acaatagtta atcaagacga tgttcacaat aatgggcata aaaataaccg cccctaatgc 3414121 agccgttcgc ggaatcagta ataaaacagc tgccaggatt tcaccaaaac ctataaacag 3414181 ttcatagaca tgagaataac cgaaaaatgt ccacgcgatc gtaaacccct tcccggcagc 3414241 cgcctcgatt tcaggcgtca cctcgccaaa ctggccaatt accactttcg ccagaccgta 3414301 cacgaaaaaa ttaaaggcta aaaacaatcg gaacgtcgcg ggaatcgact tgcgtaccgc 3414361 tttcctcagc ctgccgcctt tattcatcat acatccccct cagtgtatta tttgatgtag 3414421 tacacttaat acagtataga gtattctaat taatgtcaat tcccttttca gctcatatga 3414481 atagtttctt ttatagatac aaagtcttat atcgcaaaaa atgccattct ccttcctttc 3414541 catccctcga taacatttct caaaaaccat gtcaggaaat cttacatgaa aatgttttat 3414601 cattcttttt tctctataat gaagaaatat aataattgct ttttattctg aaagatacgg 3414661 aggaatgaga catgcaaatg ggcgatacag tttttatgtt cttttgcgct ttactcgtgt 3414721 ggctgatgac cccgggatta gcgttatttt atggaggaat ggtaaagagc aaaaatgtgc 3414781 tgagcactgc catgcacagt ttctcttcca ttgccatcgt ttccatcgtt tgggtgctgt 3414841 tcggatatac acttgccttc gcaccaggca attcaatcat cggcgggctg gagtgggcag 3414901 gcctcaaagg ggtcggattt gatccgggag attacagcga taccatcccc cactcgttat 3414961 ttatgatgtt ccaaatgacg ttcgccgttc tgactacagc gattatttcc ggggctttcg 3415021 cagagcggat gcgattcggc gcttttcttt tattctcggt tttatgggcc tctttggttt 3415081 acacacccgt agcgcactgg gtatggggcg gcggctggat cggccagctt ggagcgctcg 3415141 atttcgctgg cggcaatgtt gttcatattt cctccggggt ggcaggactt gttcttgcca 3415201 ttgtgctcgg caaacggaaa gacggtacag cgtcttctcc gcataacctc atttacacct 3415261 tcttaggagg agctttgatt tggttcggct ggttcggctt taacgtcggc agcgcattga 3415321 ccttagatgg tgtggccatg tacgcgttca tcaacacaaa caccgcggct gcagccggga 3415381 tcgccggctg gatcttagta gaatggatca ttaacaaaaa accgacaatg ctcggagcgg 3415441 tatctggggc aatcgccggg cttgtcgcca ttacgccggc tgccggattt gtcacaccgt 3415501 tcgcttccat tattatcggc atcatcggcg gagctgtttg tttctgggga gtattctcgc 3415561 ttaaaaagaa attcggatac gacgacgcgc ttgacgcctt tggcctgcac gggatcggcg 3415621 gcacatgggg cggaatcgca acaggattat tcgcaacaac ctctgttaac tcagcgggcg 3415681 cagatgggtt attttacggt gatgcaagct taatctggaa acaaatcgtc gccatcgccg 3415741 ccacttatgt ttttgtattt attgtcactt tcgttattat taaaattgta agcctcttcc 3415801 ttccccttcg cgcaactgaa gaagaagagt cacttgggct tgacttaacg atgcacgggg 3415861 aaaaagcata tcaagattct atgtgaggag tgacgctatg agcggtcaaa tgttcaaggt 3415921 agaaattgta acgcgtccgg caaattttga aaagctgaag caggaactcg gaaaaatcgg 3415981 agtgacctct ctgactttct ccaatgtaca cggctgcggc cttcaaaaag cacatacgga 3416041 gctctatcga ggggtaaaaa tagaaagcaa tgtatacgag cgtttaaaaa tagaaattgt 3416101 ggtcagcaag gttcctgttg atcaagtgac agagaccgct aaaagggtgc tgaaaacggg 3416161 atcaccaggt gacggtaaaa tatttgtcta tgaaatcagc aatacgatca acatccgcac 3416221 aggcgaagaa ggacctgaag cactttaata tcggtacgag attcggacac tccggatctc 3416281 tttttttgtg cacagaatcc ccccagaaac cgcgattcct cttcgaattc tcttcaagcg 3416341 ccgttatttc agacaatctc tatttttatt tgaaactttt catgagtaag attagtctac 3416401 taaatataaa aatgtaaaag gtgattattt gaactacgaa atttttaaag caatccatgg 3416461 actatctcat cacaattcag ttctcgattc cattatggtc ttcatcacgg aatatgccat 3416521 tgtcgcctat gcccttatcc tattggcaat ctggctgttt gggaacacac aaagcagaaa 3416581 acatgtgcta tacgcaggca tcacaggaat tgcaggcctt gtgatcaact atttgattac 3416641 gcttgtttat ttcgaaccgc gcccgttcgt tgcgcataca gtgcatacac tgattccgca 3416701 tgctgcggat gcttcatttc caagtgacca tacgacaggt gcattagcga tttctattgc 3416761 gatgcttttc agaaaccgca aaatcggctg gccgcttgtc atttttgggc ttttgacagg 3416821 cttttcgaga atttgggtgg gacatcacta tccggtagat gtattgggca gcctcgttgt 3416881 cgccatcatt atcgggttcc ttttctttag attttcagat ctgcttcgcc cgttcgtcga 3416941 tttggtcgtg aggatctacg aagccattat caataaactg acgaaaaaac caaccgatca 3417001 aaatttctaa gaaagacaaa agccggcgtc tgaaatcaag acagccggct ttaatatttc 3417061 tcatacatct cttgttttct tcgcttcgcc aacacatata aaccataaaa caacccaatt 3417121 ccaacagcat cgatgagcac atcccggata caaccattcc tgctgaagaa gagctgaaga 3417181 acttctgtga aaaaagcaaa cgcaaatgag ccggctgcag ctgatcttat gctgccccgc 3417241 tgtttccaca gcaaatatgt cagcacaaag aaggaaaacg cgtgtccgat tttttgaata 3417301 aacgcttcag gtacagtaag ctcagtaaaa tccataacta aaaattgaga cagatcaggg 3417361 tgcggctgaa aatgaaaagc caccgtttgc gatacgacca tgccgctgaa gctttccgta 3417421 cagacagaaa gcaggataaa aaagatccag cctgcgagca ataggcggtt catgacataa 3417481 cctcctttat aacgtacgtg cctacatgta actacataga cggtaaaaca aagcaaaaag 3417541 taacagaaaa aaacgcccat cacaaggata gacgttttct tcattaagac tgttcagtgt 3417601 cttctgttgt gctgctttct ttagaaccag atttgtcagt tgaatcatcc tttttctcac 3417661 cggatttttc ttctgttcct ttttcagttg atccgtcctt tttctcggaa gattgctgaa 3417721 tggattcttc tgtttcttgg gtggcagctt tttcaataga agaaactggt ttgtccataa 3417781 agtttaacgg attcattgca accccatctt tacggatttc aaagtgcacg tggtttccgc 3417841 tgtcttcact gtaaaggttc ttgccagatt ttccgatcac ttgattttgt tttactttgt 3417901 caccttgctc tacgcttact tcggaaagag attgatacac agtcgataaa ccgtcggcat 3417961 gttctacttc cacaacatat cccagcactg gatctttttc agctttaaca accgtaccgc 3418021 tcagagaagc agagacatcg aaatcttttc cgtctttctc agctaagtca attcctttgc 3418081 ttaggctgta cgtgttatta taggtaacga gtgctgcttc tttctcttct tttgcggcat 3418141 cggtttcata gaactttttc acaacagaaa cgttttcaga atcaacaacc ggcattgcga 3418201 cattttccat tgactttcct acttcaactg catcgtcgtt gttgtcatat gcggagtttc 3418261 cgccgttatc agccaactga tcctttacct catcatttga tactgattga taccaaagga 3418321 cagctgttaa aatgacggcc gcactgacta agtaaattgc agggaacacc cagcgtttac 3418381 gaaaaaactg ctgaagtttt ttgacttgag aagttttctt ttcttcctct ctcattgttt 3418441 catcacctca gcaacattct gaacactttt ctgaaaatat atacaaccta tccaaaaaaa 3418501 cttttttaga tgtagtttgc acagactgaa cgaaaatatg tatttttttg agaggagtgc 3418561 caaaaacgta tgaacatgac attgcgtctt gctgaacata gagacttgga ggctgttgtg 3418621 gcgatttata attcaacgat tgcttctcga atggtaacag ccgataccga accggtaact 3418681 cctgaagacc ggatggaatg gttttcggga catacagagt cacgtccgct ctatgtggcc 3418741 gaggatgaaa acggaaacgt cgctgcctgg atcagctttg aaacatttta tggaaggcca 3418801 gcctataata aaacagcgga agtcagcata tacattgacg aagcatgccg cggcaaaggt 3418861 gttggatcat atttgcttca agaagcgctc cgcattgccc cgaatcttgg catccgctca 3418921 cttatggcct tcattttcgg gcataataaa ccaagcctga agctgtttga aaagcacggg 3418981 tttgcagaat ggggactatt ccccggcatc gccgaaatgg acgggaaaag atacgattta 3419041 aaaattttag ggagagagct ttcatgatta gtctggataa agatgaaaac gaaattgaac 3419101 atcataatga agaaaatagc cttgttgaac aggagactgc acctgttgga caggagagcc 3419161 gccagctgag cgcctccgct gtcaagtcgc tatccgacat tgccaagtgg ggcaaaattt 3419221 ctggcatctt gttaatcatt atgggatcgc ttgtcactct gtctgttttg atgacagtga 3419281 ttggcgccat cccgggcgta ctgctcatta tttcaggcgt atttttgatg cgctcagcaa 3419341 aagcagccgc ggaagccgaa ggaaatctaa ccggcagcgc tggcgaaagc atgcttgaaa 3419401 attacgggac atttataaaa atgcagctgt tttatgcagc atccagtatc gttactgtcc 3419461 tgatcgggat cattgtagcc attttcgtgc tggtggtaat cggcattgct gcttttgaga 3419521 acacgccttc gtatgatgat ccggattctt attattatga ggatgatccg gtgtttgaat 3419581 aatgatgaga caggacaggg catgagttcc atataaacgg aaccatgcct attttatttg 3419641 actattcaaa gcaggccggc gtaaacacca aatcctgaag caagcataca atagacatct 3419701 ctagtagagg aaatcaacaa agcaacgctg ttacccagaa atgaatatca aaaaaacgga 3419761 tgaagtcgga atcaatccga aaccgcactt tttatttcgg gtgtctgcat gcaaaaaaac 3419821 acacccggat cgtctggaaa atctcaacaa tccgggtgca gatcttcttt aatacatttt 3419881 tttgcgtctg tcttcctcag tcaaaaattc aacaaaactc cgcatcgcaa aaggctcttc 3419941 ctttatttgt cgtgcgtagg agcttttccg ctcttctgaa aggatttcgc tctttttgat 3420001 cctgttcagc atatagatgt gaaccgtttt ttggatttgt ttatgctgat agcctgcctc 3420061 tttaaaaaat gcgagcccga gcgccgccaa aagggcgaat atgcctgcgc tgatcaggga 3420121 ctccctgtca gctgaagcat gaaatagaaa agcagctaaa ttaaagagag agaatgcagc 3420181 aagcggaata gcaagaaaac ggtaaatgac ggtttttttc atgaaaggct gtacggcctt 3420241 ttgaattttt tgcatttctg ttttgatgaa ccccggcatt tgttcgactc tgtaaaagtt 3420301 catataatcc tcccccttta tttgatgttt caagcttcac gaacgttatc atatgtgttt 3420361 attttaacgc aggtgcaagc tggttttaaa gaaatctgcc cgtatttttc acgaagaatc 3420421 tggatcgccg ctctttattc ttttaaaatg tgagtgttat aatttgtaat gggaatcaga 3420481 tcactgttat tcatggaata ctaatggcaa tcttcttgat aaatatgaat gagcggggtt 3420541 acaaagtgag tatttcttcc atccttttat cacttttttt cattttaaat attcttttgg 3420601 ccatcattgt catcttcaaa gaacggcgcg atgccagtgc atcttgggcg tggctgcttg 3420661 ttcttttctt tattcccgtt ttaggcttta ttttatactt attattcggc cataatctca 3420721 gacgcaagca tttgtttcaa tgggaagacc ggaaaaagat tggaattgaa aggctgctga 3420781 agcatcagct tgaagattta gaaaccaagc aatttcagtt taacaaccgg gcaacctttg 3420841 ataacaaaga tttaatttat atgctgatta tgaataacca tgctgtgttt acagaggata 3420901 attcagttga cgtcattaca gatggacggg ataaatttca gcggctgctg agtgacattt 3420961 caaaggctaa ggatcatatc catttacagt attatattta taaaggcgat gaattaggca 3421021 aaaaattgcg ggacgctctc atccaaaagg cgaaagaagg tgttcaggtc agagtgcttt 3421081 atgatgaact cgggtccaga acgctgagaa aaaagttttt taaagagctt cgcgaggctg 3421141 gcgggcatgt ggaggtcttt ttcccgtcaa agctcaggcc gattaacctg cggctgaatt 3421201 accggaacca tcgaaagctt gtgatcatag acggtatgac cggttatgtc ggaggcttta 3421261 acgtcggaga tgagtatcta gggcttaatc cgaaattcgg ttattggcgg gatacgcata 3421321 tccggctgca aggaacggcc gtgcacgcca tccaaacacg attcatcctt gactggaacc 3421381 aagcttctca tcaccatacg ctgacatata ttccaaatca ctttcctgat tacggcccaa 3421441 aaggcaacgt cgggatgcag attgtcacaa gcggccctga ttcggaatgg gaacaaatta 3421501 aaaatggcta catcaaaatg atttcgaacg ccaagcgttc cattttgata caaacacctt 3421561 attttatccc agatgcaagc ctgctggatg ctttaaggat cgcttgcctt tcgggcattg 3421621 acgttaacat tatgattccg aacaagcccg atcacgcctt tgtatactgg gcgacacttt 3421681 cgtatatcgg cgatctgctg aaagccggag ccactgtcta tatttacgat aacggcttta 3421741 ttcacgcgaa aaccatcgtg gtggatgacg aaatcgcttc agtcggcaca gcgaacattg 3421801 atgtccgaag cttcaggctg aattttgagg ttaatgcatt tatttacgat atcaccattg 3421861 ctaaaaaact ggtttcaact tttaaagaag atttgctagt atccagaaaa ttcacctatg 3421921 aggagtatct gcagcgcccg ttgtggattc gaataaaaga atccgtctcg cggctgttgt 3421981 cgccgatctt ataagatgcg taaacccccg gcctttacgg ccgggggttt tcctgatggt 3422041 cacagtaaat gatgattgcc tcccgcaaaa aagcggcaag accttctcca tattgattga 3422101 ttgaatcggt aaatcgctcg tcagtgatat acacttcccc gagtcctctg aaaatgtcga 3422161 gtgtgcaatc gtaatgatat tggcaaatat gatcgcgaaa tgcccccaca gcggcctgaa 3422221 tctctgcatc atcgggccca tgcttcattc gcgccgcaat tcgtctgtaa atcgaatcaa 3422281 attcagccat gatcgtgcgc caatcatctg ccgagtatgc agatgtcctt ttctctgttt 3422341 cttctgcgat ttcctttcca tacagctttc tgacttcatc agcgtatgtc tgctggtgct 3422401 cttcaatgtc tttcatgctt aatccggcaa ataaatccct cttattcatc gtttcccctc 3422461 catcaacgga caaaagcgtc ctgtcaattg tttgaatcat ctcatccatt ctttgttttt 3422521 tcttcatcaa tatctccttt tgcgactgaa gtgccgcttt ccggtcaaaa ttcggatgat 3422581 ccagcatctc tttaatctca tccagacgaa acccgatttc cttgaaaaat aaaatctgtt 3422641 gcagtctttc caggtctgcg tcactgtaca aacgataccc agcatcagta agcgctgaag 3422701 gattcagaag ctcaatattg tcatagtgat gaagcgtccg aatgctaacg cctgatatct 3422761 ccgccacttg tttaacttga tatttcatac ataacacctc ctctttttta tcgtaaacaa 3422821 tcacgcaacg ttagggtcaa tccccaaaat gttattttct atatacaaaa cttctcacaa 3422881 atagtgtata aaagaaaagt gagtattttt ttgtaaaggg gagccagtat acatgaatcc 3422941 tgaaacaatg aacaaaaccc tcatcagcat ttcgaaatgg ggaaaagcta caggcatttt 3423001 atttattatt atgggcgcaa ttaccgcgct ttcaggcgcg ttcttttttc taatcggtgc 3423061 cgtgccaggc gtactgcaaa ttatttccgg tatctttttg atgaggtcag ctagggaagc 3423121 aggccaaatg gctgaacaca atagcggaca gtctgaagac ttaatgctgg agaattacgc 3423181 gaaattcgta aagatgcaag ggatttattt gatcgtaagc attgctgtat ccattcttgc 3423241 gattatcgcc ttcttcatct ttttaatgct tgggattgct gacggccttt tcagcgatac 3423301 gtacagcact tattaatgag aaaaacccgg agctggctcc gggtttttta ttattccgct 3423361 tcgcttacca ctgtgaagcg ttcatttttg tgttcgggat gttcaagctc gtccaacacg 3423421 gcaatggcat aatctgcata gctgatatag ctgtctcctt ttgcatttac gatgacattg 3423481 tcttttcctt tttggtaaga gccagtccgt tttcctgctg gatcaaaaaa tgccgcagga 3423541 ctgaggaacg tccaggaaat ggagtctgtc tgctgcaaat ctttcaggtt ctcgccttga 3423601 tttgatgcag ttggcaaata ttctttcgga aattccggcg tatccattaa acgggttgtt 3423661 ttggcttcat caacaaacag gcttcccgct ccgccaacaa caagcaatct tgtgtgcttc 3423721 gcgtccttta aaatgctgat gagtgctctt cctgcttcaa catgaagatg ttcttggccg 3423781 ggtgctgctc caaaagcgtt tacgaccgcg tcgaaaggct tgatgtcttc cgcagtcagt 3423841 tcaaacacat ctttttccaa aatcgctacg tcttgctcct gcacttttga agcgtttctg 3423901 acgatggctg tcacttcatg gcctcttttt ttcgcttctt tcaaaatctc gtttcccgct 3423961 ttcccgcttg cgcctataat accaattttc atttttcatt tcctccttat ttgtaacaat 3424021 tttagttaca tgttagcggt gagaagtcat cccttttgat taaaagagat gattcataac 3424081 atcttttaat gacttgcttg ccagttcatt ttccatcgct ctttgcacac tttcaaacgt 3424141 ttcatccaga gcgttctgaa tttttttccc taccggacat ttcggattcg ggttttcatg 3424201 aaccgcaaag agttcttctt gcttttggac agcccggtac acttctaaaa gagaaatatc 3424261 agcaggatct tttttgaggc ttgcacccgg caccccggcg cgtgatgtga gaatatcagc 3424321 ttttttcagc aggctgatca ttcttcgcac aactaccgga ttcgtgttga cactgtctgc 3424381 aatgatttct gaagatgttt tttcatccat cgagatgagg gataaaatat gaatggcaac 3424441 agcaagacgg ctgttaatca tgttttttca ccaccgttgt aactataata gttacatttg 3424501 attcgtttgt caacatctaa tatacactaa atacatgggt tttgtgcacc gtttttagtc 3424561 aatagaacgg ccggatgcac tccggccgcg tcttatcaaa ataagaaata tctttgtcca 3424621 agtgggacat aatcgacagg ctggcaagac aattcctccc cgtcagcaaa gacctgatag 3424681 gtttttggat caatctcaat cttcggcaaa gccgaattca gcttcatatc cagcttgctc 3424741 agctttctga tatttttgac tggagaaatc cttttttcca gccctaagct ttccgccaca 3424801 ccacgctcta tgcttgcctg agacataaat gtaatcgagg ttgagcggtt ggcttttccg 3424861 taagacgcat acatttggcg catgaaaacc ggttcaggag tcgggatgga cgcgttcgga 3424921 tctcccattt gcgcacgtgc aatcatgccg ccctttaaga ccagttccgg tttcacgccg 3424981 aaaaataccg ggtcccacag aacgagatca gcaagcttcc ctttttccac cgagccgacc 3425041 tcatggctga gcccgtgcgt aattgccgga ttaatcgtgt atttggcaat gtaccgtttt 3425101 gcgcgcacat tgtcattccc gttttcaccg gcaagagcgc cgcgctgttt tttcatttta 3425161 tcggctacct gccatgttcg gatgatcact tcaccgaccc gccccatcgc ttgggaatcc 3425221 gatgatgtca tgctgatcgc acctatatca tggagaatat cctccgcggc aatcgtcgcc 3425281 gccctgattc tggaatggct gaatgccaca tcttcaggca ctttcgcatc taaatggtgg 3425341 cagaccatca tcatgtcaag atgctcatcc atcgtattaa cggtataagg aatggttggc 3425401 gttgtagatg acggcagaat gttcgcgtaa gaggcgagct tcataatatc cggagcgtga 3425461 ccgccgcctg ccccttcaat gtgataagta tgaataaccc ggtccccgat cgcgtcgagc 3425521 gtgttttcca aaaagcccgc ttcgttaatc gtatcggtat ggatggcaac ttgaatatca 3425581 gcctcgtcca cgacttccat acacgtttta atggcgcttg gcgtcgttcc ccagtcttca 3425641 tggagcttaa gaccgatggc gcctgcttcc acctgctcga tcagcggcgc tttatcggat 3425701 gcattccctt ttcctaagaa gccgacattg atcggaaact cctcggccgc ttccagcatc 3425761 ctcgccatat accacgcccc ggacgtacat gttgtcgctt tgcttcctgt agcgggtcct 3425821 gttccgcctc ccaaaagggt cgtcacacct gaagaaagcg caacttccat ctgctgagga 3425881 caaataaaat gaatgtgcgt gtccactccc ccggctgtta aaattttgcc ttcaccggaa 3425941 atcacctctg tccccgctcc gatgaccatg tgcggatcga ctccatccat gatatcagga 3426001 tttccgcttt ttccgacacc gacaatccgg ccgtctttca caccgacatc cgctttgaca 3426061 atgcctgtgt aatccaatag cacgacgttg gtgataacca aatccaaagc gccgtccttc 3426121 cctgtgattc tgccgttttg gcccatgccg tctcggatag tttttccgcc gccaaagatc 3426181 atttcttcac cgtatactgt gaaatccttt tcgacttcga tccataaatc cgtgtcgccc 3426241 aatctgattt tatcgcccgt tgtcgggcca aacagttccg catattcctc ccgtgacatt 3426301 ttcatcggat tacaccctcc atccagccgg cttgttttaa gttggccaac gttttttctt 3426361 tgccgcgttc atcgataaac gtgtcggcca ttccgttcag ccctctaatt gtcttgcgtc 3426421 ctctgatttc cactagtgag accgttttct gctctcccgg ctcaaaacgg accgacgtgc 3426481 ctgatggaac atcaagacgc atgccgatcg ccagctcacg gtcaaataat aaagccccgt 3426541 tggcctccgc aaaatgaaaa tgcgaaccga cttgaatgga gcgtgatccg gtgtttttta 3426601 ccgttacctc ccgtatctca cggccttcat taatcgtaat ggttccctca gcaatttgaa 3426661 atgctcccgg cttcatgact tcacctccgc agaaattggc tgatgtaccg taacaagctt 3426721 tacaccatcc ggaaatgtgg cctccacctg aatgctgtcc agcatctcag gcacaccctc 3426781 catcacatct ttttccgtta atacatggcg gccggcttcc atcagctctg ctactccctt 3426841 cccatcacgt gcgccttcca taataaagca ggtgatataa gcagcagcct caggatagtt 3426901 cagcagaacg ccccgcgcct ttcgctgttt ggctaattcc cccgctgcaa aaatgagcaa 3426961 tttctcttgt tcaactggtg tcagtttcat ctgtagtcct ccttcttttg tcatataaag 3427021 cagatgcggc tactacgaat ttgcggaaca gtcaggcggg acatcacctc cctttcttcg 3427081 agaatggggg tcatacggta agatgccttt caaagcggca tgccgtttct tcatcagcct 3427141 tgccatggtc aacaaccgtt cccctgtcga tcacggaaag atcagattaa cgcgttttcc 3427201 agactgcgct cgactaagat aacaaatgtc tttttttctg gaaatttcta taataacttg 3427261 tctgactagt tcgacaatta aaatctgaat tccttccaat tgtttattaa gtaaaatatt 3427321 tttcagattt accatcagcg ctctggtgat tgcaagctgc tgctgttgac cgccttttcg 3427381 ttttgaacaa acgtttgatt aaaacaaata gccccctctg tttagccgga gtcggcctaa 3427441 tacagcgaca atctgccccg ggcgaagcta aggctgtgca aaaccatcga ttgatcataa 3427501 ccagacgtta cattcctgat ggcagcccgt tgttttgctc cgcaaccgga agcatggcat 3427561 ggaggccagt ctgaggcgcc gacctccacg ataccgagaa cccgactatt gccattaact 3427621 ccgcatcatg gacggtcact tcgctgatcg ccaccgttcc tcttaatgag tgaagaattc 3427681 cggccttcac tgaatccccg cttgtgtcga tatcaactgt tttctcgcac tcccgtggct 3427741 tccgacactt tcttcggtgc agtacattcc gtcatcaaaa cccctttgtt tgatttcttc 3427801 aaatgatgtt ataaaagttt acaacttatg tcatcattat atagaagagg cctattaatt 3427861 caaagaatat ttaaaaaatt tagttacctt gaccaaatca gcttcttttt ttgttatatt 3427921 tattcacatc agaaaaagcg aaaaaaaaag acaagaaaca tttcgtttcc tgcctcttcc 3427981 gtacgattaa tctttatctg aaaatttatc cttggctttc ccgatatcct tttggatttc 3428041 gccttttgcc ttatcttttt tgccttcagc ctgcatgtcc gttctgtcag ccatatctcc 3428101 gactttatcc ttcacttctc ctttggcttt attgaagccg cccttcattt tgtcttttac 3428161 actatcgtta cccatgttaa ttctcccctc tcaattatgt gtgtacttgt taacttcccg 3428221 atctgagagg caataaacat tctaatgtta tttatcgatt tcgtagcgct ctccgtaacg 3428281 gagcaccttg tatatcgcca gcccgtctga tgactttttc tccgaatatc ggaccggcag 3428341 cagggcaaaa aacacataat acgtagaaaa atagacaaac tgatagaaaa acacattcgg 3428401 ctttaataca ctgtgtataa tcagcagatt gattgcaaaa atcgtgatga ggttaaacaa 3428461 gcagccccct gcatacacga gtgcatttga gaatcgattg tcaattttca actccccgta 3428521 ccggcaaaaa gaatcgataa aataaatcgt tctgaaccgt atgggtccaa ttttaagcag 3428581 cgtttttccc atgcctatat ccaacgatcc ctttccgcca aaaataaaag ccataaagct 3428641 gtgccctgaa acatgtataa tctgtacaag cggcagaaca atgaggaaag accacagaaa 3428701 cttcaccata tcattaaaac caaacattga attccccctc acatgcatat ctgcatccca 3428761 aaacggcttt tgttcaaaaa acagtgctgt agcgattttt cctgttctcc ccggaaataa 3428821 acgttccgat gctccccttt ttttgcataa aaaaaaacca tctgccagca gatggttttg 3428881 tctcatactt catataaaca atcgttcctt tgaatcatct ctctcatgct gaccgctttt 3428941 tcataaaaat acaccgcttc tttatattgt tcgcgatgac tgaaataaga ggcagcatct 3429001 aaagcaaatt cttcaatata tacatacagg cccttttctt ccatataatc aaatacttct 3429061 tgaatcatat tcaaattgac agattccaca tataatgcct gcagaaattt atattttgcc 3429121 agactgaaga agtcgtttcg tttttgggca atggcaatcc ctttttcata gtaccgtatc 3429181 gcggcttcgc tatcttgttt tttgaaaaga acgcgagtca ggctgaagag cgcttttgga 3429241 agctgttcca gctgataatc ctcgaagaca ggaagcgctt tttcaaagta ttcggcggcc 3429301 tgatccagct cccccttgtc atcatagcaa ttaccaatat tataaagggc tgatccgatc 3429361 aaacggggct gtccttccaa taaagcaagg cgatacgcgt catctaaatg ttcaagcgct 3429421 ttttcataat ttctgtagtc aatgtagttt cctgatatga cgaaatggca ttgaattctt 3429481 ctgactctgt aaaaatcgtg agccttatac gtctccagcg cctgtacggc atggttcatg 3429541 gaaaagtgcg tctgcttcat aatataaaag acttccgcca ctttaaaatg aaattccgct 3429601 ctttcaattt catcttctac aaacgcaagc atcttctcag ctttccgata aaaggatata 3429661 gccgagatgt aattgttctg ttcaaattcg tacattcctc taaacaagtg aaaataatac 3429721 tcagataatc cggagatgct gtcctgattg ctttccagcg ttttgatcaa ttcacgatat 3429781 tgaagctgag attcctcgtg caggtcaggc tttacataat ccagcataat ttggtgccgg 3429841 tagctgatca gctgataata caggagaagc agctgatcct cttccatctg ttcgatatct 3429901 agatcaattt cttctttcag ttttacggca tcagccactt gaaatgctaa aatgtgctta 3429961 taccacttat tgattttcac tcctacttga gatgacggga tctcgtacgc ggccatgccc 3430021 ctccaaccct ttctattttc taattggtta tattttatca taatgtatgg ctttggaatt 3430081 aaattttctt acaatgattc cttctttatg cctatcctta tatatttcgg tttttctacg 3430141 tattttttgc actcggattc taataaaaaa gcttaccgga cagtgccgat aagcttttga 3430201 cttcaaatta accgccaata taagacattt ccactttctt tttgccagat gcttttgata 3430261 gcgtacgatc gactgaatac tgatcgatcc gatttttcca tactgtcccg atcatttctg 3430321 atagttcgtc atcacttaat tcctggcgaa ccggagctct gaggtcaaat ccgcttgaag 3430381 cgaataagca ggtaaacagc tctcctctcg cagaaagacg ggctctgttg caagatccgc 3430441 agaatgcatc agatacagat gatatgacgc caatttctcc ggagccgtcc aagtagcgga 3430501 atctggaagc cacttcgcct atataattag gcgctatcgg ctcaaccggc atgtgtttat 3430561 tgatcaaatc tatgatttcc gcctttgtca tgacgtcttt cttttcccat tggttggtgt 3430621 tgcctacgtc cataaattca atgaatctca ggatatgccc tttttcttta aaataacggg 3430681 ccataggcag tatatctttt tcattgacgc ccttttgaac gaccatattg attttaacac 3430741 cgagccccgc ttgcttcgcc gcttcaatgc cttccagcac cttgctgaca gaaacaccgc 3430801 gcccgtttat cttcttaaaa cgctcgtctt ctaaagaatc aaggctgatc gtaacccttt 3430861 tcagcccagc ctccttgagc ctcttagcat aaacaggcag cagtgatccg tttgtcgtca 3430921 tcgcgatgtc acgaataccc ggtatgcggg ccagtttttt gattaattcc ggcatatcct 3430981 ttctcatgag gggctctccg ccggtcaagc ggattttttc aacgccaaat cttgtgacaa 3431041 acaatgtcgc aagccgttcc agctcctcaa atgaaagcag ctcctctttc tttaaaaaag 3431101 gataatccgg gccgaataat tcggcgggca tacagtacgt gcatcggaag ttgcagcggt 3431161 ctgtaacaga aatgcgaagg tctctcagcg gtctgtttct tttatccaac atctgacgcg 3431221 actctgtaat catagctaca gccccttcct actccctgat tctctcaggg tgtgtatata 3431281 cattaaatga tccgtttctg acaaatccaa tcgctgtgat attcaattct tcagccattt 3431341 gaatcgcaag ctccgtcggg gccgatttgg aaatgacaat cgacacgccg attttggccg 3431401 cttttaacag gacctctgat gagattctgc cgctgaacac aatcagtttg tcgcgtacgg 3431461 acatcccgtt tagaaggcag tgtccgtata gtttatcaag tgcgttgtgc cgaccgatat 3431521 ctgtgcgcat caacagaagc ttctctgtgt cgcaaagcgc cgcattatgg acgcctcccg 3431581 tatcctgaaa cgtcccgctc ccttgctgca tgtctttcat aagcgccaga catgcctcag 3431641 gcgatatctt gatttggctg acagccgtct tggctgtttt gacatcctgc tgaaaataaa 3431701 aatgacggcc ctttccgcag catgagccga tcacccgttt cgtataatcc ttttgatcca 3431761 atgtctcagg gtgaacgagg tcgacatata caaaaccgag actttcatct attgtaaacc 3431821 ttttaatttc tttttgaaat cgtataacac cctctgatgc gagaaatccg atgacaagct 3431881 cttcgatatg ctcaggcgta caaacgagcg tcacaaattc actgccattc agtatcactg 3431941 tcaaagggaa ttccgtcacc atccggtctt ctactttgct tatttcccct tgttcatagc 3432001 gccatacatc cctgaccgca gttactttat cgttcaatgt ctcttcccct ccgcaatgtt 3432061 cctgccttta tattttttca cactcctcgg attttgtcga attctgagac acaaaaagag 3432121 ccctctatat aaagggcttt tacaggatgt gatgacggcg gtgtttaggc aggacgccta 3432181 agcatttagc cgccgttcct tttataacac gtgagcacca atgtgcattg acaacgaacg 3432241 cggggtttgt cgacacgctg agacacctct gtataaagga ctctatgttt gattatgctg 3432301 attctttttc agaaccgtaa acagcacaat agctgcgatc aaggtgagaa tgctgacaaa 3432361 aaagaaggct gccagtttta gaagaacacc aagcaatata aatgcaacgg tggctataag 3432421 aaaaatcatt ccgaataatt tcatatgttc aacccctttt tagggtatca ttcccgccca 3432481 aactgttttt aaaccaataa aaaaggcgcc tgggggagcg cctgatcttt aggttcctta 3432541 ctcagtaaat ttttgtgctt ctttttccca agcctgttcg aactcatccg cactgttcgc 3432601 tgaaatatat tctccgccgc cagcgacagc tgcttgtttc atctcttcat tacccttgac 3432661 atcaaagttg aagccaatga tgtttacaat cgtatccaca tttgatgcac ggagcttttc 3432721 gatttccgcc gcagggtctc cgccgcacgt ttcttcaccg tcagtgatta aatacaccac 3432781 gtttttcccg tctgcgtcaa atgcttcaaa ttcttttctt gtgtctgcaa gtgctttggc 3432841 aatcggtgtc catccagtcg gcttgagctc actcaatgaa ttgtcaaaca gagacccttc 3432901 atatggatga aggccgtaaa tggtttccgt cgtactgcac gaaagggctt taccggacag 3432961 tttattgttc cctgcatgcc cgaaaacgcg aagcataaga tttgtatcct ttggaagaag 3433021 ttcggcaaaa gattttactg attttttggc aatgtctatt ttgcgctctc ctcctgtttt 3433081 ttgaaccatg cttccgcttc cgtcaaacaa aacagctaca tttgtatcag cctgtttctc 3433141 agcggcaaaa gacggggagg caatggaaac agtcaacaat ccaatgatac cggcagccag 3433201 caattttttc atatgattac ttcctttctt tttcatattt tccaactata tgttggattc 3433261 ttctttatgc tagaatacga aaatgcaaaa agatatagga catgctgcct tttgtgctgc 3433321 tttcacgatc tgtccaaaat cgcttgaaat gccgttcatt tttagccatt tccgcccaga 3433381 aagcataaac agcttgtgtg atcattcatt cttttttcgc cttgattatg acagaaaaac 3433441 ggaaatctgc tactatgcta caggcagaca gctaattagt tttgaagttt ttgttacata 3433501 caaaaagagg ctgaccatca ccagcctctt ttttcttatt tagataacat tagtgattgc 3433561 tgagtgaaaa ttttctcaac atctttttgg gtataagccg ggaagtattc accgccgcct 3433621 actttcgcaa ttgcgttcag ctggcctttg tatccctctt tataatcaaa gccgatcaca 3433681 ttaacagtga tattgtcttt ttgcagttcc tttgctgttt taatcgggtt tcctccgcac 3433741 gtttcctcac cgtctgtcaa cagatacacc actttttccc cttttgcatc aagctggtca 3433801 aaagaagatt tcgcctcgtt cagcgctttg gcaattggcg tccagccagt cggcccaatt 3433861 gtattgagag aattgaggaa gctttgctcg ttaaagcttt ggaagccgta tacgttgcga 3433921 atggcttcac atgactgaac ttttccggaa tttttattgt ttccttcaga gccaaacacg 3433981 ctcattttca cctgagttcc ttctggcaat gagctcgcaa actttgaaat ttcttttttg 3434041 gctgaattaa atttagatac accatctatt cttttcgcca tacttccgct ggcatcaagc 3434101 aagaccgcca cgttcgccgg cgctttagcc tccgtttctg tcttttcagc tgcaaaagca 3434161 ggtgaagtta atccaaaaag caatcctgtc atcatgatca gtgaaaatct tttcttcatg 3434221 ttcgtacccc tttaccaatt tgtttctgcg tgcagatgtt caacgctgaa cataatctat 3434281 cgtaatcaac aaaaaccgag aaataaatag ggcgggcttc cccattgctg ttgtttactt 3434341 ttgcatagaa acctatgttt ttattagtga tttccaccta acgcccctat gaaaagagaa 3434401 gattgtccgc ctttcggctt tcgttatatg agtctgtcga agtctgtcga caaatgtgga 3434461 tgactttacc acaatctcaa agcctgaaat caggaaaaaa ggactgatcc ttaaagacgg 3434521 tcagaagctc ctctaaaccg tttcagctac tcttagataa aagatattca ggaacagaaa 3434581 aagacgccca atgagcgtct ttttctactt tttcgccata tatttattca aaaacgcatc 3434641 tgcctcagaa atttgtgtgc cttggtaata gtactttaca atgtcatcaa ccgttttgcc 3434701 ttctttggcc ataaaattcg ctccgtattg gctcatcccc acaccgtggc caaatcctct 3434761 cgtcgtgact gtaattgtgt ctccatttcg cttccattca aaatcggcgg agttgagacc 3434821 caacttttca cgtatgtctc ttcctttcag cgtcttgccg ttaatgacgg cagttgcgac 3434881 ctggtggccc ggtgtctcgc cggtaatctt ccctactgcg ctagatccat ccagcttgac 3434941 gccaagcttt tgctgaaatt ctgccgctgt aaaggttttc gttgccttat atttcggaga 3435001 ctttttatcc catgggcttt tgacgctttt taaatatggg atagcacttg tccaataagc 3435061 ttctgcattc tctgtgtagc cgttgcttgt ggagaaaaag gatgcttcaa tcggctggtt 3435121 gttgtacgtt aagattttgc cttgcgtact ggctaccgca tctgtgattt tcttcagttt 3435181 tgtctcatag cttgtgcccc actgtttttt cagctccgct ttgcttttat acacctggaa 3435241 catctgtgta tcatccacca gtgagccttt aggagcttct accgctgaat ttgacaccat 3435301 cagtctgaca ataaatgttc tggcggcaag cgcctgggct ttcagcgctt caggtttaaa 3435361 ggttgccggc atttcggagg cgacgactcc aatcacatac tcttcaagcg gaatgttttc 3435421 tacggattga tttgcggttc gatagacggg aatagaaaca ggtgatgctt tcaatgtttc 3435481 tgctcctttc gatgctggtt tcgtgctgac tgctgtcttt tctgattcta cgctggcccc 3435541 cgcttcctta ttatgctgga atggtataac caagagtgtg ggaaccaaga gaatcaatgc 3435601 acatagtacg gatagtgtga ttgcgaattg tttcatattc agctgcctcc tgctcgggat 3435661 tcgactctag tctagtctat gggcagggac aagctaatat gactctcgtt ttggacagaa 3435721 actttatttg tcatttacgt attctttttt gctattttgc gcataatgat gataatacac 3435781 aaaaaataaa aaaccagtat gccagagtga catactgatt ttcaagtaag tttatgcatt 3435841 taagtcagaa acgacttctt tattctcttg ctcagaagca gactcatcat ttacacgttc 3435901 gatgtctgcg cccagagcgg caagcttctg atggaaatca acgtaaccgc ggtctaagtg 3435961 cttcaattca gtaacacgtg tgtgaccttc agccactaac cccgcaagaa tcagcgctgc 3436021 acctgcacgc aaatcagtcg ctgcaacttc agctccctga agctgtacag gaccgttaat 3436081 gatgacagaa cgtccttcaa tcttgatatc accattcata cggcggaatt cttccgcatg 3436141 cataaaacgg ttttcaaaaa cggtttctgt aatcatgctt gtgccgcttg cacgaagcag 3436201 aagcgccatc atttgtgact gcatatcagt cgggaagccc gggtgaggca ttgttttgat 3436261 gtcaatcggt ttaagctctt tcgggccgat gacacgcaga ccttcacctt catccttaat 3436321 tgttacaccc atctcttcca tttttgcaat taaagaggtg aggtgctcag gaaccgctcc 3436381 ttttactaat acgtttcctt cagtgattgc agcagcaacc ataaatgtgc ccgcttcaat 3436441 acggtcagga ataatatggt gttttacgcc gtgaagcttt tcgactcctt caattttgat 3436501 ggtgccggtg ccagctccgc ggatttttcc gcccatgccg ttgatatagt ttgctaaatc 3436561 aacgatttcg ggttcttttg ccacgttttc cagcgttgtt gttccttcag ctagagcggc 3436621 tgccataatc aggttctctg tagctcctac acttgggaag tccagataaa tttttgcgcc 3436681 ttgcagtcgg ccttttactt cagcttcaat gaagccatta ccgactttga tttctgcgcc 3436741 cattgcttca aaacctttta aatgctgatc aatcggtctg gaaccaattg cgcatccgcc 3436801 cggaagtgca actcttgcat gacctgtacg cgcaagaagc ggccccatga caagcacaga 3436861 cgcacgcatt ttacgaacat attcaaaagg tgcttcagtt tgcaaagcgt atgaagcatt 3436921 tacagtcact tcattatttt caaaatgcac atctgctcct aaatgacgca acacttcgtt 3436981 aattgtatat acatcggaga gcgtaggtac atcacaaatt acgctttttt cttcacttgc 3437041 taataaagat gcagcgataa caggtaaaac ggcattttta gcgccttcaa ctttgactgt 3437101 gccgtttaac ttctgaccgc cgcggacgat gattttttcc aaggtattcc cctccgcgtc 3437161 cctaaattct ctatattaat attcagtcgt aacgattggt gtgccaaccg taacggtatg 3437221 ttttccgccc attcctgcac ttctaagtgc aatttgcaaa ttcattttat gtttcgaggt 3437281 cataatgtac tcttcccact catctgtaaa cgcagaaata gaaacgaaat ttggctcaac 3437341 tacatgttct actgatcttg cttgaaattc atttaataac tgatttgctt ttttttgcaa 3437401 aacaatattc atattatcat ctaagtgacc atttagacaa gtaaaaataa ctactttttc 3437461 ttggaatatc ccaagtgtct cccgttcaaa ctgttcatat gtatcattcc agctatccgg 3437521 tgtctctaga ctcatttgct catataataa atacgaagtt ggattgtgtt ttttgagggt 3437581 tgtgacaagc tgcagtctaa aagaagtacg attttttttg tcagtatatg tgccaattgc 3437641 ctttatcatt ttatcttccc gtgcaatcac ccaatcatat tgacgatact cttgttttaa 3437701 acgttgcact ttttgataaa attctttttc ggtcagtgac aagttttgtt ttgcatgcaa 3437761 tgtccactta tctattgaca catcttgacg ttccatcccc tctgccatct gtgctaacgg 3437821 cgttaattca ctcgcatgaa tggtatggaa aacagcaatg acgaagctta acatgacgga 3437881 aatgataata gcgtggctta cttgtttttt cttcatgttc atctctcccc cttatcccca 3437941 gttttaccgg aggcaagagg cgccatacgt aaaaatcttc gtcaaaactc gagctattcg 3438001 cttcaacccg cttctcccaa ccatttaata atgttcaaaa cctattaaaa tagataggga 3438061 agctgctgtg aataattgag gtaatctaaa aagaaattgg caacggccgt tccaatggcg 3438121 attgtcagca aaatcatcag gagtcttgcc tgcacgactt tgcctttttt gattaacgga 3438181 tctatattga cggcttgcaa cgcccaccaa gtcactgcta taaaaatcag gtgaacgaca 3438241 atgccgattg cagcctgctg tcccaataca ctcatctatt acactccttt ctctgcgttc 3438301 ataccctttc ttattatata agaagcacag ataaagatga tacattttat acagaacgga 3438361 ataatcagcc aaatctaggg ctaatccccg cttaaagtgc gattctttta catggtatac 3438421 tttattggaa aggagctggc aaatgtgaat cattcttttt ttcagcctga aaagcaatat 3438481 ggtgaggacc tgccaatttt tgatcaggaa tgggaagcaa ttgcattcta ttatgattat 3438541 agacagtcac agattgaaga actgaatgaa ttgtgtcagt tttttaacat ttctcttacc 3438601 tatacgagag aaagccttga agagcttgaa aacctctatt ttcaaagtat acaagaactt 3438661 ttgcttgctg attggaatct tcctattgaa gaattcgaga aaatgatcag tgtttatctt 3438721 atagattgtg tgattgcccg ccatgaagat gctgaatggg ttgtaaaacc ttatccctat 3438781 aaagacggcg cttatacact tggctttaga agacatcgca aatcgtggca tacaatgaat 3438841 gcctgtgatg gtttatacct gcgtccaaaa gaggatcgcc cgttgctgtc gctgtttgat 3438901 tctcttgtgc gttcataaaa aaatccttct cataaagaga aggatttttt cttatttccc 3438961 tgctacatcc aatctgttca aagcccgctg taacgcaagc tcagcccgac gaatgtcagt 3439021 atcatctgat tgagaattca aacgctcctg cgcccgctgg cgtgcagctt cagcgcgctc 3439081 tttatcgatg ccttccgctg tctcggcagc ctgggcaagg atggtgacat gatcaggacg 3439141 gacttctaca aaaccgccgc tgacggcaac catttcagtc tgcccgtctt ttttcagacg 3439201 gacagcgccg attttaagag gagccacggt tggaatatgg cctggcaaaa taccgagatc 3439261 gccgctttcg gctctcacac tcaccatttc gatatccgca tcgtatactg ggccgtcggg 3439321 agtaacgata ttgactttaa cggtcttcat gcttttaccc tcctaggacc agattaaact 3439381 tctacaccca tttcttttgc tttctcaaca acttcttcga tacggcctac aagacggaat 3439441 gcatcttctg gaagatggtc atatttaccg gctaagattt ctttgaagcc ttgtaccgtc 3439501 tcttttacag gcacgtaaga acctttttgt ccagtgaact gttcagccac gtggaagttc 3439561 tgagaaagga agaactggat acgacgtgcg cggtgaacga caagtttgtc ttcctcgcct 3439621 aattcatcca taccgagaat cgcaatgata tcctgaagct ctttgtaacg ctgaagcgtt 3439681 gactgtactt cacgcgcaac cgcatagtgc tcttctccaa caatttcagg agcaagggcg 3439741 cgtgatgtag atgccaacgg atcaaccgca gggtaaatac ccatttcagt taatttacgc 3439801 tcaaggtttg ttgtcgcatc caagtgagcg aacgttgtcg ccggcgccgg gtcagtgtag 3439861 tcatcggcag gcacgtagat cgcctggata gatgtaactg atccaacgtt cgtagacgtg 3439921 atacgctctt ggagctgacc catctcagtt gcaagcgtcg gctgataacc aaccgctgaa 3439981 ggcatacggc caagaagggc tgaaacctct gaacccgctt gtgtgaaacg gaaaatgtta 3440041 tcgatgaaga acagtacgtc ctgtccttgt acatcacgga agtgctcagc cattgtaagg 3440101 cctgtcaaag caacacgcat acgtgcgccc ggcggctcgt tcatttgtcc gaataccatg 3440161 gctgttttgt tgattacgcc agagtcactc atttcgtaga aaaggtcgtt cccttcacga 3440221 gtacgctctc ctacgccggc gaatacagag ataccgccgt gctcttgcgc gatgttgttg 3440281 attaattcct ggattaatac ggttttacct acaccggcac caccgaacaa tccgatttta 3440341 ccgcccttaa tgtaaggagc aagcaaatca acaactttaa tacctgtttc aagaatttca 3440401 acttctgttg aaagctgatc gaatgaaggc gcctgtctgt gaatcggatc ctttttcgca 3440461 tccgcaggaa ccggctcatt caaatcaata ttttctccga gaacgttaaa tacacgtcca 3440521 agtgttacat caccaaccgg tactgagatt ggcgctcctg tatctacagc ttccataccg 3440581 cgctgaacac catctgtaga tgccattgcg attgtacgga ctgtatcatc acctaaatga 3440641 agagcgacct caagcgttaa atcaatacct acttcgtttt cacttgcagc tggctgtgaa 3440701 attttaatcg cattataaat ttcaggcaag tgaccgtctt caaaacgcac gtcgacgacc 3440761 ggtcctaata cctggctaac gcgtcctttc ttcatcgcta tccctcctga caaaatcttt 3440821 ctattctaaa gcggctgctc cgccgacaat ttccgtaatt tcttgtgtga tggctgcttg 3440881 gcgagcgcgg ttgtaagaaa gcgaaagtga atcgataagt tccttcgcgt tgtctgtcgc 3440941 gtttttcatc gccgtcattc ttgcagcgtg ctcacttgct ttactgtcaa gaagcgcacc 3441001 gaagattaag ctttctgcat attgaggaag caaaacctcc agaacctcct cttcagatgg 3441061 ttcaaattca taagacgccg ttctttttcc gccgccgctg cccaaatcag ataacggcag 3441121 aagttttttc tccgttactt cttgagtaat ggcgctgaca aaatggttat aaacaaggtg 3441181 caattcatca aacgcaccgt ctataaacat ttgaatcgtt tgacgggcaa gatctttaat 3441241 ttctgtaaac gttacttcat ctccaagtcc tgttaactcg gaaatgatcg gaatctcccg 3441301 tttcttaaag aaatcacggc ccactcttcc gatggcaatc accgcatact catccttaga 3441361 ctgatgacgt tcttgcatgg cctgataagc actccgtaaa accgaactgt taaaagcgcc 3441421 ggcaagaccg cggtcagacg taatgacaag gtatgccgtt tttttcactt ctctgctgag 3441481 aagcatcggg tgcttcacgt tgccggaaac tcttccgacg tttgacacaa cctcttggat 3441541 tttatccata tatggcacaa atgattttgc attgttttca gcacgattca gcttagccgc 3441601 agataccatc tgcatggctt ttgtaatctg acttgttttt ttcgttgacg tgatccttga 3441661 cttaatatcg cgtaatgagg ccaaagattt caccaccttt tctcttcatc tgcgtaaaaa 3441721 gagagaaaaa gagaaccttt ttctctcatc agcattcgag ttagttgctt ggtgcaaatg 3441781 tgcgtttgaa gccttcgatt gcagctttga agtcttcatc agcaggaagg tttcctgttt 3441841 tcgcaattcc gtcaagcagg tctttatggt tttggtcaag gtacatgtag tactcttctt 3441901 caaaacgtct gatatccgcc acaggaatat catcgagata tccttttgtc agcgcataaa 3441961 gaatagctac ttgcttttca accggaagcg gcttgttcag atcctgcttc agcacttcaa 3442021 ctgtacgcgc accgcggttc agttttgcct gagtcgcttg gtcgaggtca gaaccgaatt 3442081 gagcgaatgc ttccagctca cggtatgacg caaggtcaag acgcaaagta cctgatactt 3442141 ttttcatcgc tttgatttgc gctgagccgc cgacacggga tacagacaat ccggcattga 3442201 tcgctggacg tacgcctgag aagaacaaat cagattgcag gaagatctgt ccgtcggtga 3442261 tggaaatgac gttcgtcgga atataagcag agatatctcc ggcttgtgtt tctacgaacg 3442321 gcagagctgt aattgatcct gcgcctttcg cgtcgctaag ctttgctgca cgctcaagca 3442381 gacgggaatg aagatagaat acatccccag ggaacgcttc acggcctggc ggacggcgaa 3442441 gaagcaagga cagctcacgg taagcggccg cttgtttaga aagatcatcg tatacaacaa 3442501 gaacgtgctt gccgttgtac ataaattctt ctgccattgt aaccccagca tacggtgcca 3442561 ggtacagaag cggtgccggc tgtgacgcag acgccgttac aacaattgta taatcaagcg 3442621 cgccgtgttt acgcaatgtt tctactacgc cgcggactgt tgattctttt tggccgatcg 3442681 caacatatac acagatcatg tcttggtctt tttggttcag gatcgcatcg atcgcaacag 3442741 atgttttacc tgtttgacgg tcaccgatga tcagctcacg ctggccgcgg ccgattggaa 3442801 tcagtgcatc gatcgctttg ataccggttt gaagcggttc atgaacggat ttacggtcca 3442861 taacgcctgg tgcagggctt tcgatcggac gagttttgct tgtcagaatc gggcctagtc 3442921 cgtcaaccgg ctggcctagc gggtttacaa tacggccgat taactcttca ccaacaggaa 3442981 cctccatgat gcggcctgtt ctttttactt cgtctccctc acggatctca ctgaaaggtc 3443041 ctaagatgac gatacctacg tttgattcct caaggttttg agccataccc aaaacaccgt 3443101 ttgaaaattc gacaagttca ccggccatac agttgtcaag gccgtgcaca cgtgcaatac 3443161 cgtcaccgac ttggatgact gtacctacgt cttgaacttc aatatcagat tgataatttt 3443221 gtatttgctg ttttatcagc gtgctaatct cttcagcttt gatgctcact taggtttcac 3443281 cccttctatc gattttcccc ggctaattga cgttcaatgc gctgaagctt cccgcttacg 3443341 ctgccgtcat aaatccggtt tccaatgcgg actttaatac cgcctattaa atccgtctgc 3443401 acttcatttc tgattctcag tgaagcgact ccggcttttt ttgcaaacac ttgtgataat 3443461 ggtaacattt ctgcatccgt cagcggtttc actgaatata cgattgcgtc ttctgtttga 3443521 cgggccacat ttgcgagttt gataaactca tctgtgagct cagggacaat cgcggcacga 3443581 tggcggtcaa tcaaaagaaa aatcgtattg agtacggact gtgacaaaga gccaaatgca 3443641 ttttgaatca gctctttttt cttcgcagcc ggcaccttcg gatggttcaa cacatcatta 3443701 agcgcttttt cattttgaaa tacttgtttt acaacaatta gctcttcttc tacttgattc 3443761 agctgagcgg actcattggc tatatcaaaa agagctgatg catatcgttt agagacagct 3443821 gatccactca tcggctttct cctacctctt taagatagtc ctggatcaat ttctcttgcg 3443881 cttgttcatc cagttctttt tcgatcactt tcgacgcaat catgacagaa agagacgcta 3443941 cttgctcacg gagagcagaa accgcctgtt ccttttcctt cacgatttca gttcttgctg 3444001 cttctttcag acgttcagat tctgcacgtg cagcctgaat aatctcttct ttttgcttct 3444061 ctcccagttt ctttgcgttt tcgataagag tttgggattc ctgtcttgct tcttttaaaa 3444121 gaacgcgctg ctcttcaatc agctgctgcg cttctttatt tttttcttca gcagacgtaa 3444181 tttctccagc gatgtggtct tcacgctgtt tcattatgtt taatagcggc cctaaagcgt 3444241 atttcttcag aagcgctaat aagattaaca tagctaacag ttggaacagg atatctccgc 3444301 cgttaaacga caatcctagt tcaagtggta attgagacat ctactacggc aactcccttc 3444361 tgcaggtttt tctttgctga tccagcagcc gcacttgtct cttttcagcc ggcaaggcgg 3444421 gatgcttatc agacataaag caatggcgaa ggttctcttg gaatgatctt cgccattttt 3444481 agttcatata aggcttttat gcttagccaa agaacgctaa gaatgcgata acgacagcga 3444541 taataggaag ggcttcaact aatgcgatac ccatgaacat aagagttctc agttctttac 3444601 ctgcttccgg ctgacgggca atcccctcta ccgtacgtga aacaatcaaa ccgttaccaa 3444661 tacctgcacc aagtgcgcct aaaccaattg caatcgcagc tgctattaaa ttcatgaaaa 3444721 agttcctcct ttaaaatgtt atccgtttgg atataatgtt ttaatgatca tgactgattt 3444781 tatgagacat gtacaccatc gtcagcattg taaagataaa tgcctggata gcaccaataa 3444841 ataaactgaa tgcttgccat gccagcatcg gcagaatggc accgattgta ccgacaagac 3444901 cgagagccac gctttgcgaa taatggcttg ttgctaatcc cgcaagcagg ccgagaagaa 3444961 tctcaccggc gaagatgtta ccatacagcc gcaaacctag agtcagcgta ttcgcaaact 3445021 cttcgatgat tttcatcggg agcatgaatg gaacaggtct taaatagtct ttggaatatt 3445081 ccttgagccc tttcatcttc acaccatagt agtgggttaa agcaacaacc atcacggcta 3445141 gcgttaatgt aatggcagga tcggctgtcg gagacttcca ccagagctca tgtccgattg 3445201 taatagagaa cggcagcccc agcatattcg acacaaatat gtacatcagc aatgtgacac 3445261 caagtgccaa gaagttagcc cctgttttta aatccattgt actgccaata atattgcgga 3445321 cgaaatcaac aatccattcc ataaagttct gggcttttcc gggacggatc gaaagcgttc 3445381 ttgtcgtcaa tatagcaatc aataaaacaa tcacactcgc cacagtaatc atcagaatgt 3445441 ttgtcagatt aaaagtaaga cctagaaatt ctatagttct gtaaccatga ttcaaagggt 3445501 tttcacctct cttccattga tgaacgttta agctggataa aggaatctat cataatgaca 3445561 gggtatattg tcattaatcc aataactgta cttgccatat gaaagtattc gggattttta 3445621 taggcaacag ccacagcaag aatcgcattg caccaccgcg ctgcgctccc gagagatcgt 3445681 atggactttc ctttctctac agctctgtca aaagcattca ttcttctgac gagcagtaaa 3445741 aaattaaaca aactgaaaac agttcccaga ataaggccta aaaaaacggt tttatacgct 3445801 gttaaaccat aacccagtac atacactgcc aaaatgaaca ataaatattt gcgttgtctg 3445861 ctaaatgtaa gcttgggatc gtccatcaat tatctgtctc ctgatgaaaa aataatgtat 3445921 agcttggata cggcaaaaat cagcggttaa cccttagtag aagacctttt ttgaccggca 3445981 aaacgggcct gttcgaaaaa atcattcatc cgcaagcctt gcagggatgc tgtttcattc 3446041 gcttaaataa atcctcataa tacgggtttg ctgagaggat ttacattgag gatgaggact 3446101 ataatgaaag ctatgaaaac cttctcataa taccctcgtt tagcatacaa tagcccctaa 3446161 catgtgtcaa tctgtttaaa gttaaaaaac tttttatact ttacgtctcc acagaatgtt 3446221 cacattttca cctataattg tatacagatt caccgaatag caaaaaactg gataaaaaaa 3446281 tgaaaccccc ttttggggat ttcatttttt attttgttcc aaacatgcgg tcacccgcat 3446341 ctccgagacc tggaacaata tatccttttt catttaattt ttcatctagc gccgcaatgt 3446401 aaatatcaac gtccgaatga tgcttctgca attcttccac accctccggc gctgctacaa 3446461 gacacatgaa acggatattt ttcgcaccgc gttttttaag gctgtgaatg gcttcaactg 3446521 cggaaccgcc tgtagcgagc atcgggtcaa ccacgatgaa ttcacgctct tccacatcag 3446581 aaggaagctt gacatagtat tccacgggtt ttaaggtttc tggatcacgg taaaggccga 3446641 catgtcccac ttttgccgca ggaatcagct ttaaaatgcc gtcaaccatt cccaatcctg 3446701 ctctgaggat aggaaccact ccgagttttt tccctgagat gactttcgat ttcgcagcct 3446761 gaaccggtgt attgatatcc acttcttcca gaggaagatc gcgggtaatt tcaaatgcca 3446821 tgagtgtagc cacttcatct actaactctc taaaatcctt cgtacctgta ttttcattcc 3446881 gtatatatgt cagcttgtgc tgaattaaag gatgatcaaa tacataaacc tttcccatac 3446941 tgtgtttcag ctcctttttt attgtcccat caacaattac acacttctat tgattctaca 3447001 aaaaaagaca ttgagtttca agaacatcgt caaaaaaccc gccgggcata agcccaagcg 3447061 ggttttagga tcttaataat ctaattcttt atataaagga aatttatcag tcagagcagc 3447121 tacacgctgt cttgcttctt caagttttcc ttcatcttcg tggtttttca atgcaagcgc 3447181 aatgatagca ccgacttctt ctaatgcgtc tccgtcaaaa ccgcggctgg ttacagcagc 3447241 tgtaccaaga cggatgccgc ttgttacgaa aggtttttca ggatcatatg gaatcgcgtt 3447301 tttgttagac gtaataccaa tttcatcaag tacatgctcc gcaaccttac cagtcagtcc 3447361 gagcgaacga aggtcaacaa ggataaggtg gttgtctgtt ccgcctgaaa cgagctggat 3447421 gccctctttc gttaaggctt cagccagacg tttcgcgttt gaaatgacgt tttgtgcata 3447481 tgttttgaaa tcgtcctgca atacttcacc gaatgaaaca gcttttgcgg caataacgtg 3447541 catcagaggg ccgccttgaa ttccagggaa gatcgattta tcaattttct tgccaaactc 3447601 ttcacggcaa aggatcatac cgccgcgagg accgcgaagt gttttatgtg ttgttgttgt 3447661 aacgaaatca gcgtaaggaa ccgggtttgg atgaaggcct gccgcaacaa gtcctgcgat 3447721 atgtgccata tccaccatga agtaagcgcc gacttcatca gcaatttcac ggaatttctt 3447781 aaagtcgatt gtacgaggat acgcacttgc tcctgctacg ataagcttcg gtttatgagc 3447841 gagggctttt tcacgcacgt catcgtaatc aatatattga gtttctttat ctacgccgta 3447901 ctcaacaaag ttatattgaa caccgctgaa gttgactggg cttccgtgtg ttaaatggcc 3447961 gccgtgggag aggttcatcc caagtacagt atcgccttgc tccaaaatcg tgaagtacac 3448021 tgccatgttt gcttgtgcgc ctgaatgagg ctgaacgttt acatgctccg ctccaaagat 3448081 ttccttcgcg cggtcacggg cgatatcttc aacgacatcg acgtgctcgc atccgccgta 3448141 gtagcgtttg cccggatatc cttctgcgta cttatttgtc aaaacagatc cttgtgcttc 3448201 cataaccgct tcacttacaa agttctcaga agcaatcaat tcgatcttag tctgttggcg 3448261 ttcacgctca tttttaatgg cgttaaacac ttgttcgtct tgcgcaggta aatgtttcat 3448321 cagcgagatc ctctcctatc cgtatcctgt tctttgtttt taccatcact attgtacatg 3448381 gtttttaagg ccgatgtaaa agattatttt taaaaaatct aaatttttat tggtaaaaac 3448441 gaatattaat aacttaaatt taatttaaag ttcggaattt atttcactat cttaaaataa 3448501 aagaaaagac tggctatgca gtcctttcat tcgcactcat aaaccgcccg cactccgccg 3448561 attagtttcg gccgtgtacg cgccaatgtc acatgagctg aaccgaggct gttttgagag 3448621 acacgcacag ggacagccac cggtttcaga tgcatgccga taaacgtatc gcctatatca 3448681 attccggcgt cagcctgaat ggtttcaaca agaacaggag acttcatctg cttaaacgca 3448741 taagacgcca tcgctccgcc cgcttttgga acgggcacgg cagaaacggt tggaagcctg 3448801 aacagcttgg ctgtttctgc ttcgacgaca agcgctctgt ttaaatgctc gcagcattga 3448861 aacgccagat ggattcccgt tttttcccgg agctcagcaa gtccgctgta gatgctttca 3448921 gcgatatcta cactgcccga tgtgccgatc cggctgccgg ccacttcgct cgtgctgcat 3448981 ccaaggacga agagctgatc ttgtttcaat tccgcttggt cctgaaactc agacagcatc 3449041 gtcttccacg tttgtttcaa ctcattcatt aaacagcacc cctacaggtt tttctcttca 3449101 taatcggaga tttttccaat acgcgtttgg tgtcttcccc cggtaaactc agtagtcagc 3449161 cagatttttg cgatttcccg agccaaacca ggtccgatca cccgttcacc catcgcaagg 3449221 atgtttgtgt cattatgctc cctcgtcgcc ttcgcgctga aggtatcgtg cgccagcgcg 3449281 cagcgaatcc cttttacttt attagcggaa atgctcatgc cgatgcctgt cccgcaaatt 3449341 aaaatgcctc tgtcaacttc gccgctaacc actttttcgg ccaccggaaa agcataatcc 3449401 ggataatcga cagagccgct gccgcagtca cagcccatat caatatattc aatttgcaat 3449461 tcgtccatta actctttgat ttcatttcga atgtgaacgc cgccatgatc cgatgcaatg 3449521 gctactttca tctgcttttc ctcccagcgt gtgtgatgcg gcccgcccgc tttattgacc 3449581 gcgcagcctg tccgctcttt gattcacacc atatgatgtg cttttcacta tattctactc 3449641 cttcacgcag gatttgcaaa tgacctgttt gcagattttc tgacaactta tctacggtct 3449701 tttttcagct gttttgccag ctgccgaaga agctcttcaa gctcatctcg cgtttgttta 3449761 tagatgtcaa ttgagccgcc gaacggatcg aggacatcac catggctgcc tgtgacatat 3449821 tcttttaacg taaacacttt atcacgataa cgtccaaatt ggctggcaat gatctgtttg 3449881 tgctgatggg tcatagccag aaccaaatca gccgattcca taagttcttc agttaatgga 3449941 gaagacacat gattaagggc aatgtgtttt tcaaacagcg cttcgactgc atgaggcgtc 3450001 gctttcccat taggtgaagc aaacacgcct gccgagcgga cattgacatt cagcccttcc 3450061 ctttctgcaa ttgatttaaa aagcgcctca gccattgggc tgcggcacgt atttccagta 3450121 cagacaaaaa taatatccat gtcagtcacc ccttattttt ctctattata tatgaagaaa 3450181 aaagaaacgg cgacttcgtt tcttttattg gtatattaaa ttggcaaaag cagctttaat 3450241 ccaaacacga ttaatatgat gcccccgagc gcttcgctgt atgtgccaag ccatgactgc 3450301 acttgttttc cgaccagcag gcccagccat gtcaacatca tgctgaacag cccgaacagg 3450361 gtaattgtga ggagcggatg cgagccgtat atccccaagc tcaagccgac ggaaaagctg 3450421 tcaaggctga cgccgatggc aaacagcaat aagcccggcc ctgccggtga catgaatcgt 3450481 tcttctgact gtttaaaaga ggccataagc atttgaaccc caagaacaaa aagcagcgcc 3450541 ccaccgatat aaaccgctaa cacgccgagg agccctgaca gcatgttacc ggccgccatc 3450601 cctgcgagag gcatgatgac gtgaaagagg ccgatgatga aaccaatata gaatatctgc 3450661 ttctttctaa gtttgaccat gcccattcca aggccgacag aaaaagcatc catccctaaa 3450721 gcaaacgcca tgatgcttaa tgtaatcagt tcgcctataa acaaatccga catacataaa 3450781 taaccccctt ggacacgccc cgctttttta gcctatgcgt gtccaaaaag ggttagaaca 3450841 tctgactgct ttcagcgaat cactcttcct ccggcggctt tcatcagcct gttcataata 3450901 gcaagaccga cacctgtatc cggaaaggat tccgctataa tgaaatccac cttattctca 3450961 tcaaagctgc gcaaagcatc atacagccct gccgcaacag tctcaagctg agcccgtctt 3451021 ccgcagctct tcacataatc agcggaataa acgcccgctt tttcttctgt cgtcaggaca 3451081 ccgacccgtc ttccaccctg ttgatattct tgaatgaggt gctgaatgcg ctctgggctg 3451141 ccttcgcaaa tggcaagagg cgctgtcggc gcataatgtg tatatttcat ccctggagaa 3451201 atcggcttct cgttttggtc gctgagccct ttatccacat ggatcggccc gatcaccgct 3451261 tcaatttgtt ccttcgtaat gccgccagga cgcaagagaa cagggatgtc gtccgcacat 3451321 gaaagcacag ttgattcgac cccgattccg gtagggcctc catccacaat accggctatg 3451381 cggccatcca agtcgtgagc cacatgctcc gcttttgtgg gacttggctt gcctgataga 3451441 ttggcgctcg gtgctgcaat cggcagtccc gattcgcgaa tcaatgcaag ggcaagcgga 3451501 tgatccggca ttctaatggc aaccgtttca agacctgccg ttacacgagg tgaaagcgca 3451561 tcaggtttgc aaggcagaat gagcgtaagt gctcccggcc aaaaccgttt catcaatgtt 3451621 ttcgcctttt ccggcgccgg gcccgttaaa tcctcaagct ggctgatatc cgcaatgtgg 3451681 acaatcaggg gattatcgct cggccgccct ttcgcctcat atattttttt gacggcatcc 3451741 gtattttttg cgtttgcgcc taggccatat actgtttctg tcggaaaggc aacgacctca 3451801 ttttctcgga gcaaagcggc tgcttgtgca atttgtggat catttgtgga taactcgtca 3451861 gttacatcca caaaccatct tttcgttttc atttctgacc aaactcctta ttcacaacaa 3451921 taaaacgatt gttttacgcg tgtaatcctt ttgaaagtat aaaagatgtc ctgtaataaa 3451981 acaagcgtta tccacaaatt gtggacaacg ctaataaaga agtggataag tatgtgtata 3452041 aactgcactt atccagacgc ttttttcatc aaaacggctc cttctgtttg ccgcgattca 3452101 cagaagtgat cagaagaaaa cagctcctcc ggtacactct cagctctttc aaaacccatg 3452161 gccgtcagaa agtccgcaga ggaatgctga tttgctacta ggtacacggt tttgatctga 3452221 tgcttttcgc acagcacctc catgctttga aaaagcgtga cgatgtggcc ttggtgaagc 3452281 ttgtccgata tgacaagtga tcgcagcagc ccctggtcac agcttatttt ttcaataccg 3452341 aggcatccgg caatgttttt ctcactgtcc tccagcataa gaaattgagt gaagccttct 3452401 ttcacgcctt catagctggt ttttgcctgt tttaaaaatg cctcgagcac atctccgtct 3452461 ttttcccttg ccacccgcag ttgataaaac atccgttcac cccgtttttg cgttctttct 3452521 tccaatctat gaggcaaatc tatttttaga ccagatgatt aggaaaaaag gtcggaaatc 3452581 cattcgacta aaaagaattt cacttctgtg ccgtcttctt tttcttcgtt ctcttctttt 3452641 ttggcttttt ccgctttagc ggttacgtcc tcaagcactt tttcagtctg cttttttgag 3452701 gcttctttat cttcttgttc tttgacggct tccccgttag aaaaatcaag aaagcagagg 3452761 ggcgggaaca gcacacacca ccagttggcg ccgtctccgt ttccaagcgt aatcaaaatc 3452821 gcttcatact caccagcggg atataccatg ttgccgtaaa gctttgtcgg aaacgagatt 3452881 ttgtcaaaat caacggatat cgactgattc gctccttctt tctccattgt ttcctttgca 3452941 attgctttga tttcaggcag ctttgaacga atcacgcgac gcgcttcttc aatagaagta 3453001 atatccttta cccaagttgt gatttcttta ttcaccgcgt ctcttatatg acgttttaat 3453061 tgctggtctt gatcactatc gctgtttgcc agtattctca aacgaatcgc ctgatcaggt 3453121 atgaccaccg gctgattttc cgatttttgt gccgtctctt cttttgccag ccctacgagc 3453181 gctccggata ataaaagaaa gatatatata caaatgatta ctgttttttt catcggtccc 3453241 caccgttcct ctccgtgctt tgtttctagc cctattatgg acaaggagag cctgggataa 3453301 acgtgcaggg tgaaaaaaat ctagcaagct gttaatctta tttatggtac gatagtgttt 3453361 taggaggttt aagatgaaat acaattatac agtgctgtta tcagcattca cgatgtccgt 3453421 tctttattca gtaatttata ttcattcatt tatcattgcc gctctcatca caatggcatt 3453481 ttattttctg tttccttatt tgatcttcgc actgccgctt caaatcatga tgaataaaaa 3453541 gccgaaacgt ttcagccctt tgtatctgct gtattacctt gccgctgctt ttattgccaa 3453601 cgcgatcatt ttcggcatgc ttcagccttc gggacaatct ctgtttcaaa atacagcctt 3453661 ttatcttttc gctgtattaa cagctcttat ctattggata tgggattctg ttttactgca 3453721 aaaaaaggaa gcctaagagg cttccttttt tattaaaaca aaatcgtcag taaataacat 3453781 agaatggaag gtatcgccgc aacaaagaaa gcggccgcca ttttcatgcg agatgtacgg 3453841 ccttctttgg tttctgaatg gtagtttgcc cgctgatcgc ttccgcttac agccaaaccc 3453901 gatgtaatga tcgcgagccc cactaaaacg agagacgcaa cgccaaaaat cgcttcatat 3453961 gaaagagcct gcggaaaaat ggtgccaatc atgctctcaa tcgcaatgag caggattcct 3454021 gctgtcaggg cctttttcat gtttacatcc cctttgctgg tgttaaacag cttgatccat 3454081 tcactcgcca gcaagctgct tatttatttt tatgaatcag agcgcatatg gttctgtctt 3454141 ttccattaat atctttcagc acttccactt ccgccccctt aaacgccttg aggatcaggt 3454201 ctttgaccgc cgctccctgt ttccagccga tttcaaaaac gacaaatact ttatccttca 3454261 taacaagcgg aatgtcttcc ataaaccgct tataaaattt cagcccgtct ccgccatcgg 3454321 tgagtgcgtg cagcggctca tgaaaacgga caatttccga taaatcagcc atttcttcct 3454381 ctgaaatata tggcgggttt gagacaatga tatccgcttt ttttcccgcc ttaataaaag 3454441 gctcaagcag atcgccctga taaaagcgca cattcgctcc gagtttttct gcattggcag 3454501 aggcgacttg cagcgcctct ttcgaaatat cgaccgccga cacagaaaag ctttggtttt 3454561 caagcgcaag cgtgacggct attgcgccgc tccctgtacc aacgtcaaca acttcgagct 3454621 tgccgtcttc agaaaaaaca ctccgatatt tttcaagcaa atgaaagaca acttcttcag 3454681 tttccggccg cgggatcagc acatcatcat tcaccataaa ttcccgtcca taaaaaaact 3454741 cttttcctat aatgtattga accggcacgc cctctttatg catctcaacg tgacgcttaa 3454801 agcgatacag ttcgtcttca ccaatcggtt cctgtaagct tgcgagcagc ttgcttctct 3454861 ccattccggt atcataaagc aataggagct cggccgcatt ttcttctctt cccgcttcgg 3454921 ttaaataaga agaagcccat ttcagggctt cgaatatcgt cttcatctta accttccgac 3454981 tgctgaagct tgcttgcctg atcttcaaca atcagcgctt caaccacttc gtcaagtttt 3455041 ccttcaagaa tctgatcaag cttttgaatc gtcaaaccga ttctgtgatc cgtcacacgg 3455101 ttttgcggga agttgtatgt gcggatacgt tcagagcggt caccagatcc gactgctgat 3455161 ttccgtgttt gatcatattc agcctgggct tcctgctgaa atttatcata gattctggca 3455221 cggagaacct tcattgcttt ttctttgttc ttaatttgag atttttcatc ctggcatgat 3455281 acaacaacac ctgtcggcaa gtgagtcaga cgaaccgcag acattgttgt gttaacgctt 3455341 tgtccgcccg gtccgcttga agcaaatgta tcgacacgga tatccttctc atggatgtcg 3455401 acctctacct cttctgcctc aggaagacat gccactgttg cagtggatgt atggatgcgt 3455461 ccgcctgatt ctgtttccgg aacacgctgt acgcggtggg cgccgttttc atatttgagt 3455521 ttagaatacg cgccgcttcc tgtaatcata aagatgatct ctttgtagcc gcccgttccg 3455581 gttacattcg cttccatgac ctctgttttc cagccctgaa gctcagcata acgggaatac 3455641 attctgtaca gattgcccgc gaataaagcg gcttcctcgc ctcccgcagc cccgcggatc 3455701 tccatgataa cgtttttgtc gtcattagga tctttcggga tcaggagcac cttcagccgt 3455761 tctgacagtg tttccgtttc cttctgaagt tcagaaatct cttccttcac catgtcgcgc 3455821 atctcagcat ccagcttctc ttcaagcatc gcttttgcat cagccagctg ttctgacgca 3455881 tctctgtatt gtctatatac gtcaactgtt tcttgtatat cagattgctc ttttgaatat 3455941 tctcttagct ttttcggatc gttgactact tctggatcgc tcaaaagctc atttaatttc 3456001 tcgtatcgtt cttcaattga ttttaaacgg tctaacacgg tcttcacctc tgttttcctg 3456061 tgcgtaacat tctcattata gtatagtgat taaccccagt caaaagcatt tcaatcccag 3456121 ctggaaaagc tccctctgct atactggaat tcgaggaggg atgatgttgc tgaaatccat 3456181 acatcatatt gcaatcatat gttcagatta cgaaaagtcg aaagctttct acgtacataa 3456241 gcttggtttt caggtgattc aagaaacgta ccgcgaagag cgcggctcct ataagcttga 3456301 tttgtcgctt aacggctcgt atgtcattga gctgttctcg tttcccgatc cgcccgaacg 3456361 acaaacccgg cctgaagccg caggcctgcg ccacctcgcc tttacagtcg gcagcttgga 3456421 taaagctgtt caagagcttc atgaaaaagg aatcgaaaca gagccaatca gaacagatcc 3456481 gctgaccggc aagcgtttca ccttcttttt tgatcctgac cagcttccat tagaactgta 3456541 tgaacaataa cagtttttga agaaaaaaag gagataccca ctttctttgc cgaatctttt 3456601 cttgttttgt ctaacgggaa gggaaccgca ttctatggtc gaatacctag cttaaaagga 3456661 ggtatgggat catgaataca aatatggtag caagtgaact cggcgtctcc gcaaagacgg 3456721 tgcagcggtg ggtgaagcag ctgaatcttc cggccgaacg caatgagctc ggacactatt 3456781 cgttcacggc agaagacgtg aaggttctaa aatccgttca aaaacaaatc tctgaaggca 3456841 cggcgattca ggatattcat ctgccgaaaa gcgctaaaaa gcgcacaggc ttccttgtcc 3456901 aaaaaacaag tagcgacaca gaacgaagaa tcgagcagct tgaacaaaag ctggacaccc 3456961 ttttacagca aaggcaggac gaaagcgaat tgatggcaag gatgtcggaa ctggaacgcc 3457021 agctgaaaca aaaagccgat gaaggtgtat cttaccagct gcttcagcac cgcagagaaa 3457081 tcgatgatat tcttgcagat ctgcaatcac tgacctcaca aatgaaagaa ttcaccgctc 3457141 attcgatccc cgagactgct gctgcttctg aaaaaaccaa aacaagaaaa aaaccgctgc 3457201 tgtcactgtt caaatttcaa acctaaagca aaaagctccc ttaaagggag ctttttttgt 3457261 tacgcagtaa gcgcgataat gattggaagt gaaatcaatg acagaatcgc actgaccaca 3457321 aacgcagttg cagtttcttc ttcttgtttc tcgaaacgag tcgcaatcat ggctgcaacg 3457381 gcagaaccag ggaatgcaac aagaaggatt gcttttgttg tttggtcagc tggaagtccg 3457441 atagcaagag caatcaggaa cattaacgca ggctgaaccg caacttttag taacgcaata 3457501 ccgatagccg gcatactgag tttaatttta cgaataccaa cggtaacacc aacagcgaag 3457561 agagcaacac cagatgttgt gcttccaagc tgatcaagca ttttaacacc cagctcagga 3457621 agagtgaaat tgaaaaccag caccaagatc atactgatta acggagcagc tgcaagcggc 3457681 tcacaaagac catgcaggat tgattttcct gtcatcttcc agaagctgtc gccactctct 3457741 tcgtttttct tagaagactc accaacagta gcgataatga tcgcgagcgg atcaagaatc 3457801 gcgttaacca cgatacctgt gaccgcgatc ggaatcgcaa cttcattcgc tccgaataag 3457861 cttcccaata ccgggatacc cataaatgcg aatgtcggct gtgcagagtt caaagaaaat 3457921 acagatgagt tcgttaaatc atacttgaat ataaatctgc aaaccaaaag aatgatgata 3457981 tagaaaccaa caatcccaat aattaaagaa atcattaaag gtacttgtga taaaaattca 3458041 cttctggaag ttgtcaaaat accagcgata aagtgagctg gaagtgcgta tttcgttact 3458101 aacgtactta ccccttttgc cgacttggca tcataacttc caaaatgtcc tgcaaaccaa 3458161 cccagcacga taacaaagaa gatcggcgcc aggaggatta agatatctaa gatgctcaaa 3458221 atattctcct ccaaatccta tgtccgtata ctttagcttt acaaaaagct ttccctcgga 3458281 cagaaaaatt tactcgctaa ttatttcgcg atgacttttt tgtattcagg tgtccacatt 3458341 gcatcaagta ccgcttgttt cacatcttca ggctgacgat ttgccacgcc gtctttaatt 3458401 gctgcttcag caacggcaat cgcaacttgg atagaaacct cttgaagctt atcaatgctt 3458461 ggaagcaatc ctgctccagg tgtttcaaga tcaaccattt cagcaatcgc atcagcagtt 3458521 gcagcaaaca tagcaggtgt aatgatacgc gcttcagcta caattgaacc aagtccaaga 3458581 ccagggaacg cgaatgcgtt gttagattgt ccgatttcat aagaaacacc gttgtattct 3458641 acattgtcaa atgggcttcc tgttgcaata agcacttttc cgtcagtcca tttgaacaga 3458701 tcttcaggaa cagcttcagc aaggtgagtc gggttagaca tcggcatgat aaccggacgg 3458761 tctacgtgag atgccatttc ttttacaatt tcctctgtga atgcacctga aacccctgaa 3458821 gtaccaatca agattgttgg tttcgcttga cgaacaactt catcgaatgg aatttgacct 3458881 ttttcatcgc gcttccagtc tttcacttca tccgcattgc gaaggtaagg tttttggaaa 3458941 tcaaggatgc cttcgatgtc ttcagtcagc aagcctctgt aatcaagtgt gtagaaacgt 3459001 ttgttagctt cttcttcaga taatccggct agcaccattg tgtcacggat ttggtcagca 3459061 ataccgatac cagcagaacc agcaccgaag ataacaacac gctgatcttt aatagaagcg 3459121 ccggttttct tcatagcggc aagcacacct gcaagtgtaa tcgcgccagt accttgaata 3459181 tcatcattaa atgtcaggat ttcatgattg tattttttca tgatgttgcg tgcatttttg 3459241 ttgccaaggt cttcccagtg aagaagcgct ttagggaaga atttcaatgc agcttttaca 3459301 taagcgtcaa tgaaagcttc gtagcgttca ccttgaacac gttcatgctt gttaccaata 3459361 tataaaggat cgtttagaag tttttcgttg ttcgtaccga catcaagcac aaccgggata 3459421 acacggctag ggtcaatacc agctgcagca gtgtagacag ccaatttacc gattgcaata 3459481 ttaataccgc ctacacccca gtcaccgata ccgagaatgc tttcggagtc agtagcaacg 3459541 ataagatcaa tatcgcctgc tgtcgcatga aggttttcaa acgctttttc aataccgtca 3459601 atgttatcga ttgacaagta gattccttga ggtcttctat attcatggct gtattcctga 3459661 atcgcttcac caactgttgg cgtgtacaca acaggaagca tttcgcgaag atggtttttc 3459721 agcaatttat agaaaagaac ttcgttacgg tttgcaagat cacttaagta aacattttga 3459781 cgaaggcggt caggctgcgc ttggaattgc tcgtacgcgc gttgtgcttg ttgatcaaga 3459841 gaaagtacag ttggcggcag aagcccttct aagccgagtt cttgtctttc ttctagtgaa 3459901 aaagcaacgc ctttatttaa agtaggaata gataaaactt cttttcctct aagagttgtt 3459961 tctaagtggc cttctttcgt tttttttatg ttattcaagc aaatctcctt ctttcttgaa 3460021 atagttaacc aagttaagta ataacccatc taaaatatga ccgatcatga tctttatgcg 3460081 actttgtgac aattattcga acaatgtctc aaaactattt acattacgta agctattgta 3460141 tgcctgtcaa aatcaaaatt caagagaaga aaattactta attttttaat atacttattt 3460201 aaatttttta attgaatatt atcagaatat aaaaaaaaca ccggtgtttt tagccggtgc 3460261 attctatctt tatacccatg ttttggacta ttttttagat ttacctggga cttcgtgatg 3460321 atgtctgcat cttgcttcat atgattcagc tgcaccaacc aaaatgaccg gatcatcgta 3460381 agaagcaggt ttgccgtcaa tgaggcgctg tgttctgctc gccggtgatc cgcaaacaga 3460441 acagacggct tgcagctttg tcacactttc cgcaatcgcc atgatattcg ggacgacacc 3460501 gaacggctct cccctaaaat ccatatcaag gcctgctgct atcacacggt agcctttatc 3460561 ggcaagagat gataaaacct caacaatttc ctgatcaaaa aactgcactt catcaaccgc 3460621 aaccacatct gtactttcac tgatgtgatc ccaaatgtcc gcagcagacg aaatggcata 3460681 gctcgtcatc gatgttccat tatgggagac aacagcagct tcgctgtatc ggttatcaat 3460741 tacaggctta aataccctga cttcctgctt ggcataagtt gctctcttca ctcttctgat 3460801 cagctcttca gatttccccg agaacatgct gccgcaaatc agctcaagcc acccgctttg 3460861 tttcattatg tacataggct tcgctcccct ctctctgcca gctgtgtttt agacaatata 3460921 aaaaacaggc aagactgctg cttgcctgtt gagaaatcta ttattactta agaccgtatt 3460981 ttttgttaaa gcgatcaaca cgaccatcag cagaagcgaa tttttgacgg ccagtgtaga 3461041 atgggtggca ttcagagcaa atctcaacgc gtacctcttc ttttactgag cctgtttcaa 3461101 attcatttcc gcaagcgcat ttaactgttg cttttttgaa attaggatga attcctgctt 3461161 tcattgtatc catctccttc cgccctgaat cccgtgtgga aacagagtta ttatttcgga 3461221 gcattgtccg aaacgcatat gagaaaatta tatcagtgat ttacttcttt tgcaaataca 3461281 atttaccttc ttgcagatga tagatttgcc tgtttccatt cttgattgag aatatcgaaa 3461341 aattcctggt ttgttttggt ttttttcatt tttctcatga acttttctgc gaaatcaggt 3461401 gaatcagaca tcgttttgcg gatagaccat aaacgatcaa gatgctcttt aggcacaagc 3461461 agctcttctt tgcgcgttcc tgaacggcgg atatcgatgg cagggaagat gcggcgctcg 3461521 gcaagagagc ggtcaagatg gagctccatg ttgcctgttc ccttgaattc ttcataaatg 3461581 acatcatcca tacgtgaacc tgtatcgacc agagccgtag caaggatggt taagctgccg 3461641 ccctcttcga tatttctcgc agccccaaag aagcgtttcg gacggtggaa cgccgctggg 3461701 tcaatccccc cggaaagcgt tcttccactt ggcggaatca ctaagttgta ggcgcgggca 3461761 agacgtgtga tgctgtccat caggataatg acgtcttttt tgtgttccac gagacgcatc 3461821 gcacgttcaa gcacaagctc ggccactttg atatggtttt ccggcacttc atcaaacgtt 3461881 gagctgacga catccccagc tacagagcgc tcgatatcgg ttacttcctc aggtctttcg 3461941 tcaattaaaa gcacgatcag ctctgcttca ggctggttcg ctgtaatgct gttggcaatt 3462001 tccttcagca acatcgtttt tccggctttc ggcggcgcaa caatcaatcc gcgctgccca 3462061 aatccaaccg gcgccatcat gtccataatt cttgtagaca agaagttcgg ctttgtttca 3462121 agcaccattt gacgatccgg ataaagtggc gtaagagccg ggaaatgcac acgctctttt 3462181 gcagattcgg gatcatcccc atttactgct tcaacgtgca aaagtccata gtaacgctca 3462241 ttttcttttg gcgggcgaac cttgccagat actttgtctc cgttccgcaa atcgaaacgg 3462301 cggatttgtg aagctgagat gtaaatgtct tctgagcttg gagagtagtt gatcggtctc 3462361 aggaatccga aaccttcaga ctggatgatc tcgagaacgc cttccataaa cagcagatct 3462421 tcctgttctg cattcgcttt cagaatggcg aaaatgagtt ctttttttgt cagtttgctg 3462481 taataggaga ttttataatg tcttgcaagt tcataaagct ctttcaattt catattttcc 3462541 aaagaggaaa tagatacgtc tttcataaaa acaccacgct tttcatagtc aatatcttac 3462601 tctgaacatg tcatctgctg cttttgcaca acatccgcca aagcacattc tttttttaac 3462661 ataaaggaac ttctatcggt aacacttcca cccatgatcg gcgcttttgt taaaaggatt 3462721 gtcttaatga gttttgaagg aagcgaggac aaaaacatga gaagatcaat acttatatcg 3462781 tctgtatgcg gtagaaattg aaactttcct agtgcttaaa agaaggtatt acgcagtaaa 3462841 attcgcagca ctctttattt ttaccttatt tcaaaaaatt attcaactga aataaggttt 3462901 tgacacggaa ttgatagagt tgacgctttt ctgcaaaagt taaagcgggc tcacacccgc 3462961 tttttctgtt tgttatggac ggattacaag atttggtttc tttttcaagc tgtgtctgcc 3463021 gtcaacgaaa cgaacagtgc ccgattttgc acggataact aagctttcag ttgtaccgac 3463081 agagcctttg aattgaactc cttttaacag ctcgccgtca gtaacccctg tagctgcaaa 3463141 aatcgcgtca tcacccttca caaggtcttc catgcgaagc actttgctta aatcaaggcc 3463201 cattttgtga cagcgagtga tttcttcttc gctttgcgga agaagtttac caatgatttc 3463261 tccgccgagt gcttttagcg caacagcgga aagcacaccc tcaggagcgc cgcctgatcc 3463321 gaacaggata tcaacgcccg tgtggtcgaa agccgtgttg atggcgcctg cgacatcgcc 3463381 gtcattgatc aatttgattc tggcgccggc ctcacgaagc tcggaaatga tttttgcgtg 3463441 tctttcacgg tttaaaattg tggcaacgac gtcctcaacg tccttgtttt tcgcttttgc 3463501 caccgcttta aggttgtcaa tgacaggtgc ttcgatgtca atgcagccca ccgcttccgg 3463561 accgactgcg attttttgca tatacatgtc aggagcattc agaagcgtgc catggtctgc 3463621 gaccgcgata accgtcagcg cgttccagcc gccgcttgct aagatgtttg tgccttcaag 3463681 agggtcaact gcgacatcaa cgcgagggcc gtacccgttt ccgagttttt ccccgatata 3463741 cagcattggc gcttcgtcca tttccccttc accgattaca acggtccctt tcatcggcac 3463801 tgtatcaaaa acgtctctca ttgcacttgt tgccgcttca tcagcctcat ctttttttcc 3463861 ccggcccatc catcttgctg atgccaatgc cgcagcttct gtcacacgta ccaattccat 3463921 tgataaactt ctttccattt caacacgatc tcctctcaca agaaaccatt atgaattttg 3463981 aagctgttct atttcttcgt cagtcattct ttcacgccaa attgtcgctc caagcccctc 3464041 aagcttcttc tcaaggctgc tgtatcctcg gtcaatatgc tccagtcccg taatttccgt 3464101 gacgccatca gccatcagtc cggctaccac caagcaggct ccggcacgca gatcactcgc 3464161 cttcactttt gcgccttgaa gctcgacagg acctgtgatg atggcagatc tgccttctac 3464221 tttcatattg gcacccattc gtctcagctc atcaatgtgc ttgaatcttg ccgagtagat 3464281 ggtgtctgtg acgacactcg tccctttcgc ccttgtcagg agcgccgtca tcggctgctg 3464341 taaatcagtc ggaaaccccg ggtatacgag ggttttgacg tcaaccggct ttaagttctt 3464401 ctgcccgccg acaatgagga gctggtcgtc gcttgtttcg atatgatagc ccatttctct 3464461 cagctttgcc gttaacgact caagatgagt agggatgacg ttatcgataa tgacttcctt 3464521 gcccattgca gcccctgcaa tcataaatgt cccggcttca attctgtccg gaatgatcgt 3464581 atgcttgcag ccgtgcagtt ccttcacgcc gtcgattcga atcacattgg tgcccgcacc 3464641 tttgattttg gcgcccatgc tggtaagcaa tgtcgcgacg tcaatgatct caggctcctt 3464701 ggcagcgttt tcgatgatcg ttttcccttc tgccaaaaca gcggcgagca taatgttaat 3464761 cgttgcccca acgcttacga catctaaata aatccgtgcg cctctcagcc tttcagctcg 3464821 caaataaatg gcgccttgtt cattggttac ttcagctccg agtgcttcaa agcctttgat 3464881 atgctgatca atcggacggg gccctaagtg acagccgcca ggcaatccaa tgaccgcctg 3464941 cttgaagcgg ccgagcatcg cccccattaa ataatatgac gcgcgaagct tttttacttt 3465001 cccgttagga agcggcatgc tgatcatcga cgtagggtca acaaccattt ccccattctc 3465061 aaaatgcacg ttgccgccga tttcctttaa caggtcacgc agcgtttcaa tatctgaaat 3465121 ctctggaagc ccttcaattg tcacctcgga atttgccaaa atggttgcag gtattaacgc 3465181 aacagcgctg tttttagcgc cgctgatatg tactgtaccg tttaacgagt caccgccggc 3465241 aatattcaac ttttccatga tagtctcctt ccataagaag atagctgcgg agctaaataa 3465301 aatgtcattt tattctgtct ctgcaaataa agctcatgtc caaaatctag ccaattcgaa 3465361 gagaaagaat acaacacatt gtaaaatatc aggaagaaaa tagcgaagct ttggggggta 3465421 caggtttcaa aagatgcaca gagacccgcc ggctcgagag acatcgtcgt catccggcaa 3465481 aagcagtacg catacccttc attccgatat cagcttctgc agcccaatga ttccttctct 3465541 gtaaagcggc gtcagcatct gaagatccgc tgtatcaggt cggtgaaata caaaggccgc 3465601 ggcaaacagg cataaagctg tttgccgccc ctttcattat ttgttccagt ctgccaggaa 3465661 ttgttcgatt cctttgtctg ttaacgggtg tttagtgagc gcatgaatga ctttcagcgg 3465721 cattgtgccg atatgagccc ctctaagagc agcttctgtc acgtgctgcg gatggcggat 3465781 tgacgctgca atgatttgcg tgtcaaggcc gtgaatgtca aaaatctgtt taacttctga 3465841 aatcaggtca agcccgttgt ggccgatgtc atctaaacgt cccaggaatg gagatacata 3465901 tgttgccccc gctctggcag caagaagcgc ctggttggca ttgaagatca atgtaacgtt 3465961 tgttttgatg cctaagtcag taagtgctct taccgctttt aaaccgtcag acgtcattgg 3466021 gattttcacc gtaatgttcg gagcgatctt cgccagttct tttccttcct cgatcatttc 3466081 ctcagctttc aaagaaataa cctctgcgct tacagaccct ttcacgacgt ctgtgatctc 3466141 gcgaagacgg tcgtggaatg atacgttagc ttcctttgct actaaactag gattcgtcgt 3466201 tacaccggcg agaattccta attcattcgc ttctctaatt tcatcgatat tggctgtatc 3466261 aacaaagaat aacattttca aaaagcctcc ctgattaaga aattttctga actgcgaata 3466321 tgattgcgct ttctaaagat agacggaaaa ccgcctgtca agctgtcagg cggctataaa 3466381 aagttccaat tgaattaagc ttggtttgaa gaaccaaatt cacgcatttt accgataact 3466441 gtttctttga tcgcttcacg agctggtcca aggtatttac gtggatcgta ctcgtcaggc 3466501 ttagctgcca atgtttcgcg aacagctttt gcagaagaaa tttggttttc agtattcacg 3466561 ttgattttag ctgtaccaag tgaaattgat tttttgatgt cagcagtcgg aattccagta 3466621 ccgccgtgaa gaactagcgg aaggccagtt gattttccga tctcttccat ttctttgaag 3466681 ccaaggtttg gctcaccttt gtaagggccg tgaacagaac ctaatgcagg tgcaaggcag 3466741 tcgatgccag tgcgctcaac aagctcttgg cactctttag gatcagcgta gattacgcct 3466801 tcagcgataa cgtcatcttc ttgtccgcct actgttccaa gctcagcttc tacagatact 3466861 ccgtggaaat gagcaagctc aacaacttta gcagttgttg ctacgttttc ttcaaatgga 3466921 tggtgagaag cgtcgatcat tacagatgtg aaacctgcat gaatcgcttt cgcacaagat 3466981 tcaaagcttg aaccgtggtc taagtgaatc gcaacaggaa ctgtcacttt gtactcttcc 3467041 ataagtgctt ttaccatagc aacgactgtt ttgaagccgc ccatgtagcg tcccgcacct 3467101 tcggaaacac caaggatcac tggagatttt tcttcttcag ctgcttgtaa aatcgcttga 3467161 gtaaactcaa ggttgtttaa gttaaattgt cctacagcgt accctttttc tttagctgta 3467221 ttcaacattt ccgtcataga aactaaaggc atgtcgaatg tcctccttat gtagcctgat 3467281 tgtcttctag cgaaaaaagc tttccaccct agcatgaccc atatattgct gtcatatgta 3467341 aatactcaga tcgctttttc tccataacta ggataccaac ttttcgacaa atcggcaaca 3467401 taatgacatg attcatttgt ttcttctttt tgtcagttag acttcagggg cagatatttt 3467461 ttgacggcgt ctctgatttc gtcgatgtca aacggcttgg caaagtgcgt cagagcgccc 3467521 aattccttcg attcctggat catgtcgagc tctccgtatg ccgtcatgat aatgacccgg 3467581 atgttttcgt caatgacctt catccgtttt aagatttcga ttccgtccat gccgggaatt 3467641 ttcatgtcca acagcacaag gtcgggccgt tcttttgtca caatgtcaag cgcctgcagg 3467701 ccgttcgcag cctgaaacgt ctggtagcct tctttattga acacttcatt tagcaaaata 3467761 cgaatgccgt attgatcatc aacgattaaa attttttcat tcatcatttt acaccccaat 3467821 attatgattt tcgtcaaaag taagcagtat tgtatgtatt ctgtttgatt ttcctatttc 3467881 ctttaattat aatagtctac tttacgacat tttctgagca ttttctcttt tgttgtatac 3467941 tgatattgta cgttataaag gaggattcac ttatgttgaa aatattcacg acgcagttaa 3468001 caggtatttt ttcccgcatt caggataagg aatctgacgc gattgaagat ggggcgcggc 3468061 tgcttgctca agcggtgatc agcgggcatt ccatttattt atacggagcg aatgagcttc 3468121 agggcgtctt ttatgaggcc accgaaagca aagaaccctt cccatctgtc aaagcctttc 3468181 cagaaaacgc tgaggaagtg acagaaagcg acagggtgct gatgttttgc tcagggacgg 3468241 gcacagccga agaacaggag ctcgcaaaag agctttatga aaaaggtgcg ggagtcgtat 3468301 gcgtatcgcc cgcagccaaa gacagtgcgg gaatagaaca gtattgtgat gtgcatattg 3468361 attctaaatt aaaaatgccg cttgttcccg atgaagacgg cacccgttac gggtttccct 3468421 ctttaatgac agcactgtat gtctatcacg ctttatcgtt tacactaaaa gaaattctgc 3468481 aagagtatgc ataatatctt attgtacatg ctggaacttg ccggaaacaa ataaaaaaga 3468541 cttgcccgct tttgacaaac ggcaagtctt ttttattact tctgatttgc agcttcgaca 3468601 gacgctccga taaagccttt gaatagaggc tgaggtcttg tcggtcttga cttgaactct 3468661 gggtggaact gagaagccac gaaccaaggg tggtctttca gctcgatgat ttcaacaagg 3468721 cgtccatcag ggcttgtgcc tgagaatacg aagccttgct cttccatttg ctgtctgaat 3468781 tcattgttaa actcatagcg gtggcggtgg cgctcgtaca ccacttcatc ctgatacact 3468841 tcaaaggctt tcgtgccttc ttcaagctta caagggtaaa ggccgagacg aagcgttccc 3468901 ccaagatcct caacatcctt ttgttcagga agaagatcaa tgatcgggta ttgagttgac 3468961 ggatcaattt ccgctgagtg agcgcctttt aagcccaata cgtttcgtgc gtattcaata 3469021 gacgccacct gcatgcccaa gcaaatgccc aagaacggaa tgttgttttc gcgcgcgtat 3469081 tttgtcgcga cgattttccc ttcaacaccg cggtctccga atccgcccgg cacaatgatg 3469141 ccgtctgttc cgcttgtgag ttctgcgata ttgttttctg tcacttcttc cgcgttgatc 3469201 cacttcactt ttacatctgt gtcaaacgca tagcccgcat ggcggagaga ctcgacaaca 3469261 gaaatgtatg cgtcaggaag ctcaacgtat ttgccgacaa ggccgattgt aatcgtttga 3469321 gacaggttgc tgactttgtt aacaagctct ttccactcgg acatttccgc ttctttgcat 3469381 gccaatttca tgtgctcgca aacaagctta tcaagccctt gtttttgaag ctccagcgga 3469441 atggagtaaa ggttgtccgc atcttcacat tcaataaccg cttttgtatc gatgtcgcag 3469501 aaaagcgcga ttttatcttt catatcttga gaaatcggca tttctgtacg aacgacgatg 3469561 atgtttggct gaatgcccaa gctgcgcaat tcttttacgc tgtgctgtgt cggttttgtt 3469621 tttaattcgc cagcagcttt aatgtaaggc acgagcgtac agtggatgta cattacgttt 3469681 tcacggccga tgtcgctctt catttggcgg atcgcttcaa ggaatggcag tgattcgatg 3469741 tctccgacag taccgccgat ttctgtaatg acaacatctg cgtttgtctc tttccctgcg 3469801 cggtaaacac ggtctttcaa ttcgtttgtg atgtgcggaa tgacctgtac ggttcctcca 3469861 aggtaatctc cgcggcgttc ttttttaaga actgttgaat agattttacc tgttgtcacg 3469921 ttgctgaatt tattcaggtt aatgtcgata aaacgctcat agtgaccaag gtccaagtct 3469981 gtttcagcgc cgtcatccgt tacgaatact tcaccgtgct ggtacgggct cattgttccc 3470041 gggtcaacgt tgatgtatgg atcgaatttt tgaatcgtca cgttcagtcc gcggtttttc 3470101 agcaaacgcc ctaatgaagc tgctacaata ccctttccaa gtgaggatac aactcccccg 3470161 gttacaaaaa tatatttcgt catttcgttt gctcctctct tcgctcttag ctacattttt 3470221 aaaatgtact attttataaa aaatcattta gccttttaaa tgatttataa gaaaaatgag 3470281 gggtgaaaat aagaaagctc cctttcaatt tcttgaaagg gagcataacg tactatgttc 3470341 tctcttcgtt tttgaagagc ccaaaataca tactacatag ttcgactatg aaagtcaaga 3470401 tcgttttgaa gatgaaatct gatactattt aatttcctct tcttcatcat catagtcttc 3470461 atcatcttca tcaataatat cttcttcgat ctcaagatca tcgtcgtctt catcaagatc 3470521 ttcttcgtca aaatcgtcgg cttcaagatc gagttcttcc tcaacttcat ccaaatcaag 3470581 gtcgtcttcg tcgatctctt caaactcgtc aagatcaaga tcttcttcga ctgctttctt 3470641 cgcttttttc tttttcgcct tgactgtcgg ctgagtttct tcatcaagct gatcataagg 3470701 ataccagctg cgaagccccc acgtctggtc agaaagcgcc aggaagcggc cgtcaatgtt 3470761 taaatctgta taaaattgag caatgcggtc tccaagctct tcttttttca cgccgagcaa 3470821 agatgcgatt tcatttaaaa gctcctgaaa aggaactggt tttttatgtt cttcaaataa 3470881 ttcgtgagcg atttcaacta aagccatttc ctttagctct tcctgtgaat attgtttgat 3470941 acccaaggtc ggacactccc tttctattac ttatatgtat ctgttttatc aataatgaaa 3471001 gcgattttgt atcgttctta tacaaaccat acctctcatt ataaacaaaa taaaacagaa 3471061 tatgctaccc ttaacagcgt taatttaaat aattttacaa gagtgatccg actgagagat 3471121 gttttccgtt aatccgcgag cattctggag atgaccagtc tttgaatttc ttgagtgcct 3471181 tcatagattt gcgtgatttt tgcatcacgc atatagcgtt ctaccggata atcttttgta 3471241 tagccgtagc cgccgaaaat ctgcacggct tcggtcgtta ccttcatcgc cgtatcccca 3471301 gccatcagtt tggacatggc ggaagctttt ccatatggaa ggcccgatga ttctaaccat 3471361 gcagcctgat aggtcagtag ccttgaagct tctatcattg tcgccatatc cgcgagttta 3471421 aaagcgatgc cctgctgctc ggcgatcgat tttccgaatt gctttcgctc ttttgcatat 3471481 tgaagcgccg catcaagcgc tccttgggcg atgcctacag cttgtgcagc tatgccgttt 3471541 ctgcctccgt caagcgtctt catcgcgatt ttgaagcctt ctccttcttc tccgagacgc 3471601 tttgatgcgg gcactacaca atcttcgaac atgatttccg ttgtcggtga agaacggatg 3471661 cccagcttct tttctttctt gcctgtaaaa aatccttcaa aatccttttc tactataaaa 3471721 gcggtaacgc cttttttctt tttctcggga tcggtgacgg caaaaacaat gtaaatatca 3471781 gcaacgccgc cgtttgtgat aaacactttg gaaccattta acacatagtc atcgccgatt 3471841 cgttcagcag ttgttttcat gctgccggcg tcagagccag accctgcttc ggtcaaagcg 3471901 aatgcgccga ttttctctcc gagagccagc tgtgttaagt actctgtctt ctgttcctct 3471961 gtcccaaagg caaacagcgg ccagctgcaa agagagatat gggcggaaag cgtcacaccg 3472021 gtggaggcgc acacttttga cagctcttcc accgcgatga cgtaggctaa atagtcactt 3472081 ccaattccgc cgtaatcttc aggccatgga attcccgtca ggcccagatt tgccatttcc 3472141 cgaaacagct cgcgatcgaa gcgttcttgt tcgtcccgtt cagccgctgt cggggccacc 3472201 tcatgcttcg caaaatcgcg caccaatttt cgtatcatct catgttcttc tgataatgaa 3472261 aaattcattg cttctccccc attttcagat cagcgcctaa aacggattga gccagaagct 3472321 cgacgacgtc gtacgttttg acttggtctt cggcttcctt cgcctttgtg ccgtccccaa 3472381 gcatcgtgag acaatacgga cagccagaac tgatcaccga tgggttgact gcgagcgctt 3472441 gctctgtcct ggcgacgtta atcctgttgc ctgtttcttc ctccatccac attaatcccc 3472501 cgccggctcc gcagcacatg ccggtttccc ggcttctctc catttcaaca agctgcacgc 3472561 ccggaatggc tttcaaaatc tctctcggcg gatcatagac ttcattgtac cggcccaaat 3472621 agcacgaatc atggaaggta atcgtctcat gaagcgggtg ctgcggtctt aattttccgt 3472681 ttttcacaag ctcggccagc acttctgtat gatgataaac ctcgccttca aatccgaaat 3472741 ccggatattc gtttttaaat aaattgtatg catggggatc gatcgtaacg atttttttga 3472801 catcattttt ttcaaattca gaaatattct tctcagccag ctcttggaac aaaaattcat 3472861 ttccgaggcg gcgcggcgtg tctcctgaat ttttttcttt attgccgaga atcgcgaagg 3472921 acacgcccgc gtgattgagc agcttggcaa aggaaattgc gattttctgg cttctgttgt 3472981 cgtaagaccc catggagcct acccagaaaa ggtactcaaa ttcttttcct tcttttttca 3473041 tttcttttac agtcggaatc tcagcatccg gcgcctcgtc acgccaattt tcacgttcct 3473101 tgcggttgag tccccacgga ttcccttgcc gctcaatact tgtcattgcg cgctgggcgt 3473161 cactgtccat ttttccttct gtcagtacga ggtagcggcg gaggtcgatg attttatcca 3473221 cgtgctcatt catgaccggg cattgatcct cacagttccg gcaagtggtg catgcccaaa 3473281 tttcttcctc tgtgatgacg tcgccgatca agcttggatt gtaatcaagc gccgctgcgg 3473341 cttcctgcga tccgctgccc gctgacgccg cagccagctg attgcctctc gtatgccgaa 3473401 acgctgctgc gggcacccat ggggagcgcg aggtgacggc agcgcctttt tccgtgagat 3473461 ggtctctgag acgcaaaatc aagtccatcg gagaaagcat ttttccggtg cctgttgcag 3473521 gacacatatt ggtacagcgg ccgcactcga cacacgcgta tagatcaagc agctgagact 3473581 gtctgaaatc ctcaattttt cccgctccgt agctttcttt cgtttcgtcg gtaaaatcaa 3473641 ttttttcaag ttttccggca gattccattc gattgaaaaa gacgtttgcc gggccggcga 3473701 ttaaatgggc atgctttgac tgaggcacgt acactaaaaa gctaagcaag aataggagat 3473761 ggatccacca tgcgatatag aaaatcaccg ccgcgcctgt tttcccgaca ccgctaagca 3473821 taaacgcaat acctgaggca attggctcgc tccaagaaag cccatgctca tgccaaatca 3473881 gattcatccc gttcccaagc agaacggtca gcattaatcc tccgataaaa atgagaacga 3473941 gtccggcttt gaaaccgcgt ttcagcctca cgagcttttc gatataacgt ctgtagaatg 3474001 cccacccaac agcaattaaa atgagaaacg taacaatttc ctgaaaaaag gtgaaggcgg 3474061 gatagaccgg gccaagcgac agattccggc cgggagccag tcctttgatg ataaagtcaa 3474121 ttgctccgaa ctgaaccaat ataaatccgt agaaaaacat gacgtgaatg attccgcttt 3474181 tcttgtcctt gagcagtttt ttctgtccga atacattcac ccatatggcg tgaagccgtt 3474241 ccttgaaccg ttgatcaaat tgttctttct ggccgagctt gatgtaggcc agtctcgttt 3474301 tgaccaagta aacaaacaaa tagacagcgt aagcggttac aatcagaaat aataatgcat 3474361 ttgcgatgag aaagccgctc attccaattc ccccttttta ctgataaaga ccgcgatccc 3474421 ctacccccga atctgtataa gattatcttt atgataaata atgaatgagt gttcagtcaa 3474481 taattaaatt cctgctgttc gggcacacta cctttactac ggaaaggagt gccggtatga 3474541 aggtatttat cgtgattatg atcattgtcg ttattttctt tgccttgatt ctgcttgata 3474601 tcttcatggg ccgtgccgga tacagaaaaa aggcgtacga gcctgttttt tcaaaaaaga 3474661 agagtgacat cgaattgatc cactgcggcg ctgatctcgt tgagcggatg atgaatgata 3474721 ttcgccaggc cgcctcttct gttcacatga tgttttttat tatgaaaaat gatgaggtca 3474781 gccacaatat gtataccttg ctgaaaacaa aagcccaagc tggcgtatcc gtttatttgc 3474841 ttctggattg ggcgggctgc cgggcaatta aaaaaacggc gcttcagacg atgaaaaatg 3474901 ccggcgtcca tgtccatgtg atgaatcgtc cccgttttcc ttttttcttt tttcacatgc 3474961 aaaaacggaa tcaccggaag attacggtga tagacggaaa aatcggttat atcggcgggt 3475021 ttaatatcgc cgaagaatat cttggaaaga aggcgaagtt cggcaattgg gaggattatc 3475081 atctgcgcat gatcggagaa ggcgtacatg atcttcaaac gctttttgct tctgatctaa 3475141 aacgaaatac cggaatcgaa ctgggttcgg atgtttggcc aaagcttcag caagggacta 3475201 tttctcacaa gatctatgcg accgacggtt attcccttga aaacatatac ttggccaaca 3475261 ttgcccaagc gaagaatcgc cttacggttt gcacgcctta ttacattcca tcaaaaccgc 3475321 ttcaagaggc ccttattaac gcaagaaaaa acggcgtatc cgtgagaatc attgtaccga 3475381 tgaaatcaga ccatccgctg gtacgagaag cggcttttac gtattattcg gagctcttgg 3475441 atgccggctg tcttatttat cgttattatc aagggtttta tcatgtaaaa gccctcatca 3475501 tagacgacca tctcagcatt atcggaacag ccaacttcga taaacggagc ctgttcttaa 3475561 atgaagaggt gaatgttgaa attgatgacg aagcgtttac aagtgaagtc tatgccacaa 3475621 ttgaggagga tatgaaaaag tcggagctgc tgacgatgga ggatttcagc aagcgcacat 3475681 tcaggcagcg cccggcggaa tggctcggca gggcattatc ttatttctta taaaggagag 3475741 ttcctatgat tttcagattc gggttcgttt caaatgcgat gagcctttgg gatgcgtctc 3475801 ccgctaaaac attgacattc gcgcgttatt caaagctttc aaagactgaa agaaaagaag 3475861 cgcttctgac tgtgacaaaa gccaatttgc gcaatacgat gagaaccctt cactatatca 3475921 tcggccacgg cattcctttg taccgttttt ccagttcgat tgtgccgctg gctacgcatc 3475981 ccgacgtgat gtgggatttt gtaacaccgt ttcaaaaaga gtttcgggag attggagagc 3476041 ttgttaaaac ccatcaactg cgaacaagct ttcatccaaa tcaattcact ctgtttacga 3476101 gcccgaagga atccgtcaca aaaaatgcgg taacagatat ggcgtatcac taccgcatgc 3476161 ttgaggccat gggcattgct gatcgctccg ttatcaacat tcatattggc ggcgcttacg 3476221 gaaataaaga caccgccact gcacaatttc atcaaaatat aaaacagctg ccgcaggaga 3476281 tcaaagagcg gatgacactt gaaaatgatg ataaaacata tacaacggaa gaaacgcttc 3476341 aggtctgtga gcaggaggat gttccgtttg tctttgactt tcatcatttt tacgccaatc 3476401 cagacgatca cgccgacctg aatgtagcac tgccccgcat gatcaaaacg tgggagcgga 3476461 tcggccttca gccaaaggtt cacttgtctt ccccaaaatc ggagcaagcg atacgcagcc 3476521 acgccgatta tgttgacgcc aactttttgc tgccactgtt ggaacgcttt aggcaatggg 3476581 gaactaatat tgatttcatg attgaagcaa agcagaaaga caaggcgctt ctccgcttga 3476641 tggatgaatt aagctccatc cgcggtgtca aacgcatcgg gggcggtgcg ctgcaatgga 3476701 agtcataaat gtgcaaaaat aggtttacga cttgtcagct ttgggaactt aggctatata 3476761 agacaacaat cgatggagga gaaagatcat gaaaaatatc aagtctctga aagtagccgc 3476821 acaggccttt actttaagaa atttgattca tctttataaa atgtgccatt ccggaagcca 3476881 cgaggtttat atttattcaa agaaaacgat gtgcaaaatc aaaagcttaa ttgagcttga 3476941 aacgttccgc atggctcata atgaaaagga atatctgatc gtagttgaag gaacaaaagc 3477001 atcacagctc attgaaaaat tccaaaatct catcgagcct gctgagagag aagcgctcta 3477061 acttacatac aaaaaaggat agacatctgt ctatcctttt tcttatgctc ttacataatg 3477121 gagctgaacc gcttgtccaa attgttttgt cccttttaac cgcagttttg tttcatttgt 3477181 tagttcgtga aacagcggga tgccgcttcc taaaacgacg ggaataacag tgatgatgaa 3477241 ttcgtcgatg gcatcttctt tcataaagtc attcacaagc tctgccccgc cagctatcca 3477301 gatgtttgag cctttttcct gtttcaaacg ggcagtgaag gctctggctc cctcattgat 3477361 aaacgtcaca tgttcatctt gataactgtc gggcgatcct gtaaaaacat agcaggtttt 3477421 atcctgatac gggaaaaccg gtgttagcac tttaacgtgc tcatatgtgc tccgccctaa 3477481 aatgactgta tcaacagtct gataaaaatc actgtagccg ttgtcacctt caccttcaaa 3477541 ttcatccagc caatcgatgc ttccatcttc ttttgcgatc atcccgtcca atgaaacagc 3477601 aatgtacagc acagtttttc tttccatgtt ctcctcctat cgatgcacca tttgcccgaa 3477661 ttgcgcttga tgcagcctgc tgtataggcc tccggcttcg atcaggtctt gatgacggcc 3477721 ttgttcttca ataccgttgt ttgtgacgac tacaattctg tccgcgtctt tgattgttgc 3477781 cagcctgtgg gcgatgacaa gcgtcgtgcg cccctcagac aactcttgaa gcgccttttg 3477841 gatcgccgct tccgtctctg tatcaagggc tgaggtggct tcgtcgagaa tcaagatcga 3477901 cggatttttc aagaacatcc ttgcaattga cagacgctgt ttttgcccgc cggaaagctt 3477961 cacgccgcgt tcgccaatca tagtatccaa cccatcgggc atgttatgga cgagctcttc 3478021 cagatgcgcc tgcttcacag cttgccaaat gtcttcttct gatgcgccta gtcggccgta 3478081 ggcgatattt tctctaagcg tgcccgagaa taagaaaacg tcctgctgca cgacgccaat 3478141 ctgcccgcgc aacgaagaaa gcgtcatgtc ttttatactg atgccgtcaa tcgtaatgtc 3478201 gccctccgat gcttcataaa aacgcggaag cagactgcaa agcgttgatt tcccagcacc 3478261 tgacggaccg acgaacgcca ccgtttcccc cgcttgaatg gataggttga tgtcattgag 3478321 gacattgtga tggtcatcat agccaaacga aacatgttta tagcggatat tgcccttcag 3478381 gccggaaaca tctttcgaat caggtgagtc ctgaatatcc ggctctgtct ccatgagctc 3478441 catatagctt ttgaaacccg cgatccccct cggatacatt tcgataatgg cattaatttt 3478501 gtcaataggc ctgaacagca cattcgtcaa gagtacaaac gccacaaatt ccccgtacga 3478561 taaggagccg cgaatgacaa accacgtccc gcacaaaagg acaaacagcg tgacaaaccg 3478621 ggtcagcata tagctgattg aaccgttttt cgccatgatt ttgtaggaag aaagctttgt 3478681 gacacgaaaa cgctggttgt tgacggcgaa gcgttctttt tcaaatgctt catttccgaa 3478741 cgcctgcaca agccggatgc cgccgatgtt attttctaca cgcgcgctga agtctccgat 3478801 atccttgttc agcgtggtaa atgctttggt catttttttg ttgaaataaa gcgctagcca 3478861 aatgacgatc ggcataatga taaacgttaa taaagcaagc tgccagttaa taaacagcat 3478921 cactccgaac gccccgagaa tggtcatgac cgcaatgaat aagtcttccg gtccgtgatg 3478981 ggcgacttca ccgatataca ttaaatcgtt cgtgagcttc gacatcagcg ttcccgtctt 3479041 gttgttgtcg taaaatttga acgagagctt ttgcaaatgg tcaaaaagcg actttctcat 3479101 atcagtctca atattgatac caagcatgtg tccccagtag gtcacgatat actgaagagc 3479161 cgagctgagc gcgtacaccg caaataaccc gattgaggtc gcgatgatca gtccccagtc 3479221 cctgcccggc agcaaggtat caataaaata attgacgatc aaaggaaaac tcagctccat 3479281 taaacctccc gcgatcgctg agaaaaagtc gagaaagaac aacgttttat atggtttata 3479341 atatgaaaaa aattgccgca gcaccctatc ttcccccaat gtataaataa ctgataatat 3479401 ttctcaatta tactatacac gggctgtttt gtaagatcag atttcttttt tcttacagaa 3479461 cacctgaaaa caggcgggca aacgactctt ttgtccggtc agccacacct cttttataaa 3479521 agccgacagg gctgagcttt tcactttcct gcatatcctc ttcaaaatgg gcctcaaggg 3479581 ttcggatcgc ttcggcatcc gtgaagaaca cattcacttc aaagttgagc tgaaagctgc 3479641 gcatgtccat attcgcggta ccgacggagg cgagatcgcc atcaatgatc atgacttttt 3479701 gatgcatgaa gcctttttgg taggagtaca cttcaatgcc ctcaaggagc agctccggga 3479761 aataggacct cgacgcgtat tgggtcaaaa agctgtcgtt cttctccggc accataaccc 3479821 ttacctctac cccctttgtc gccgctgctt ttagcgccgt gcgaatggat tcattgggga 3479881 caaaataggg cgtggcgatc catattgatt tctgcgctga agaaatcatt tcataataaa 3479941 ggtcgctcat gctttccttc atgtcagggc ctgtcgcgac aatttgataa atgcctcctc 3480001 cttccacggg aaccggggta ttgtactcct cttgatcaat tagcacttca ttggagacat 3480061 attcccaatc cagcataaag atagcgtgga gcgtttgcac aatttccccc tcaagccgca 3480121 ggtgtgtatc tctccaaaat ccgatgtacg gatctctgct gatatattcc ttcccgacat 3480181 ttaatccacc cacaaaaccg gttttcccat cgatgatcac gattttccgg tgatttctga 3480241 aattcagctt ctggttgaaa aacccgtatt tcagcggaga aaacgggacg atgtccaccc 3480301 ccgcttgttt cattctcata atatctcttc ttgccagctt catgcttcct gccgcatcgt 3480361 ataaaaacct cacctcgaca ccctggcgcg ctttctccat cataatatcc atcatgccgc 3480421 gtccgagcat gtctgattta aacatgtagt attcaatatg tatgtaagat tccgcttttc 3480481 tcattgcttt gaaaatgtcc gggaaggttt cttcgccgtt tttcagcact ttgatgttgc 3480541 ttttcgtatt gatattcata tgggcagccc tgatggaata tgtaaagaac ctctcttgat 3480601 tgtccttcag ccctgtcact tcgggcgttt cctccttgtc aaacagcttc ctgagctttt 3480661 ccctgttgta cattcgtttt gtcttaaaca gctttccctt tacataaagc tgtcccgaaa 3480721 acagataaaa cacgtagccg acgattggaa aaaagacaag aatatggatc catagcagcg 3480781 tgtgctgcga ggtgcggttt tcaagaatta atgaatagat gctgaacaaa ataatgctta 3480841 tatagcaaag caatcctccg taaaactcaa gtctggaaac cggaaaaaac caaatgacat 3480901 atgccccgat gagcatcata tataaaaaga aaaattccag tctccttttc agcatcctga 3480961 ttctctccaa tctgattcaa ttacctctgt attacctctt ttttctaatc gataaacctt 3481021 gtaagtaaaa aacctctccg ccaaaggagg agaggtttag agaaaactaa ctgtcacgga 3481081 attcatccgc atcgtttctg cagaaataaa gcaagactat tggcaacgcc gagtgacaac 3481141 atgagcggca agctgaaccc gctcagcact ccggcaagcg ccgaaaagaa ggcggcgctg 3481201 tgactgcaaa tacggtggat agagtaaatt tgatacccat tctgatgaga gaaaatatat 3481261 aaaacgggaa attgatcaga aagatataag gagttagtca ggctgaatca taatctggct 3481321 gttccgccgg tttaaaatga gtaaaatcct tgatgttatt tccatataca aacataacag 3481381 gattcccggc agcccagcca ttaccttggc agaaaaaacc ccctcttgca agggggattt 3481441 tcacgagcgt ttccgatata caacgtagct gcgggtcaga tacttgagcg gcagactgaa 3481501 cacatgaacc aatctcgtaa acggccacag gataaaaacg acgtatccta tcacaatatg 3481561 aaacttaaac catagcggga cactctccat caaagaggcg tcaggcctga acaaaacgat 3481621 ttccctgaac cagggcccga ctgtggtccg gtaatcaaat cctttcgaat caatgttgag 3481681 aaacgtggcc gcaacgcctg acagcatcat gaacagcagc aggaggagcg taaggatatc 3481741 ggatggcgag ctcgttttgc ggattctttt gtcaaacagc cttctgtacg tcaggatgac 3481801 aagtccggta catgccgcaa tgcccgccgg caagccagcg ccaatcgcca ttttgtgata 3481861 catatgctct gaaatgccaa gggaagcata cacgccttct gggatcagaa tccccatgac 3481921 atgcccgccg acaacgcaca gcagtcccca gtgaaaaagt gtgctgccag ccgcaagttt 3481981 tttcttttct aacagctcgc ttgatttcgc cgtccagcca aattggtcat gctgatagcg 3482041 gtaaatatgg ccgccgataa agattgtcaa tacaatgtat ggcataatac cccagaggat 3482101 ctgcccgctc atgcctgaac agccccttca acgctttcac gtacgccaat gttttcaagc 3482161 gcggccagca gcacgtgcag cagttcagcg tatatactgt catttttttc gagacgggat 3482221 gccagctccc tcacattgga cagatatttc tcaaacacgc ttctcgctgc ttcaatttct 3482281 gcagccgcag caaattccag catcagcggc agataatcag gcagctcttt ctctgtcggc 3482341 aggaaaccgg attgctcgta tgtgtttttt aaatgcagca attcaatgcc gcgttccctt 3482401 tgctcgcctg agttaaagta ggtgacatac atatttgttt ttttcccgaa gtcgaatgta 3482461 tagacatagt gttcaatcag cgcttccgga gaatagctgg ctgacgtctc gaaaaagtgc 3482521 agcagcttct cccggatttg ccggttgccg atttcttgga taagagcctt ccaatcggga 3482581 agctcggctc tccactcttc atccggataa gagagaagac aggaaagagc agagaacgtg 3482641 atttgccggt ctgtggtgtt catcttgtta cacctcattt atcaaaagtt agaaacagga 3482701 gccggggccg cctgaaaatg ataagccgca gcttccttgt tcagcgtata aatctgatac 3482761 ttcttctcga tggctgctcg gaatcacaaa gcggtcatca tatttggcaa tcgcaagcag 3482821 ccgatacata tcttcaattt gctgttctgt taagccgaca ctggagatca gttccggatc 3482881 gattgattta ttcgtctgga ccgctctcat atactggcgc atgacagaca ttttctttaa 3482941 tgttgaccga atatgatccg tatcaccggc tgttaacagc tgcgccaaat aatctatcgg 3483001 gattctcatt tggtcgatag ccggaaaaat atcttccgcc gtttgccggc tgccttttcc 3483061 ttcaaagaga ttcataatcg ggctgagcgg cggaatgtac cacaccattg gcagcgtgcg 3483121 gtactcagga tgaagcggca gcgcgatctt ccagtcaatg atcattttat agatcggtga 3483181 ttgctgcgcg gcctctatcc attcagccgg aatgccttgt tcttttgcca gtttggcaac 3483241 ctcaggatca ttcggatcaa gaaaaacgtc caattgggaa tggtagagat ccttttcatt 3483301 ttcaacagat gccgcttcct ccactttgtc cgcgtcatat agcatgacgc cgaggtagcg 3483361 gattctgcca acacacgtct cagagcagat ggttggcagt cccgcctcca aacgcggaaa 3483421 gcagagtgtg catttttccg ctttgttcgt ttgccagtta aaatagactt ttttataagg 3483481 acaggatgag acgcaatatc tccatgaacg gcatgcgttt tgatccacaa gcacaatgcc 3483541 gtcctcctcg cgtttgtaca tggcgccgga tggacaggat gagacgcatg ccgggttgat 3483601 gcagtgctcg caaatacggg gcaaatacat cataaagacg tcatcgaatt ctgttttgat 3483661 cgattcctcc atcttttgta cgttgggatc ttcaagtccc gtaatgtggc cgcctgcgag 3483721 atcgtcctcc cagttcggtc cccattcgat attcatgaaa tcccccgtca aggacgattt 3483781 cgggcgtgct accggctggt gttttttctg cgggctgttc gttaatgttt cataatcata 3483841 gttccaaggt tcatagtaat catcaattga cggctgattc ggattataga aaaggcctgc 3483901 aagccgattg gttttcgagc ccgatttcag ctcgagcttt ccttttttca atgtccagcc 3483961 gcctttatat ttgtcctggt cctcccattg cttcgggtag ccgatgcccg gctttgtttc 3484021 tacattattg aagtacatat attccgcacc ggaacggttt gtccacgtgt ttttgcaggt 3484081 gacgctgcac gtgtggcagc cgatgcattt atccaagttc atgaccatac cgatttgcgc 3484141 tttaatcttc aagccaatcg acctccttca gcttgcggat gacgacgttc aggtcgcgct 3484201 gattccccgt tggaccgtaa taattaaagc cgtagctgag ctgggcgtag ccaccgatca 3484261 tctgtgtcgg cttgacgtga atccttgtcg ggctgttatg ggtgcctccg cggttattcg 3484321 tcagctttgt gccgggcacg ttgatgtggc ggtcctgggc atggtgcata aacgccattc 3484381 ctttaggaat ccgatgagac aaaacggctc tcgcgacgac aacgccgttt cggttgaagc 3484441 attcaatcca atcgttgtct ttgatatccg tgtcctctgc atcatcttta ttcatccaca 3484501 cggtcggccc gccgcggaac agcgtcagca tcggcagaga atcaaaatac atgctgtgga 3484561 cagaccattt attatgcggc gtcaaataat tgaggacgat ttcttttccc tcttgatcag 3484621 gccgtttgct cagaaacggg cgatgctgga ggatcggttt gaatgtcgcc atcgtttcac 3484681 cgaattccat catcagttca tgatcgacat aataggattg tctgcctgtc agcgtccgcc 3484741 acggaattaa tttttcaaca ttcgttgtaa acggcgaata cctgcgccct cctttttcag 3484801 agccggtaaa cgctggagac gtgatcaccg ttttcggctg ggctgtaatt tgttcgaacg 3484861 taaagcattc ttcctcgcgt tcttccgcca ggtctttcag cttcaggttc gtgatgtttt 3484921 caagtgattc ccatgctttt actgcgacct ttccattcga agtggatgat agggttaaaa 3484981 tcgcttctgc agcctgcttt gcttcactta tatttggaca tccctttgcc acgctgtccg 3485041 aggtgatttc tcccagtctc tgtttgagtg attcatattc atcggctatt gaccagctca 3485101 tcccttttgt tccgctcggc tttaaagcaa cgttcggacc aagtgcagtc attttatgaa 3485161 aaatgtgttt gtaatcccgt tcaacgactt ggatgttcgg catcgttttt cccggaatgg 3485221 cttcacattc gcctttgctc cagtcattga ttttgccgaa tggctgggcc aattcctgca 3485281 tggtgtcgtg gagcagcggt gtcgcaacca cttctttcac cggctccata tcgacttctt 3485341 ctgccagatc ggaaacggct tttgacagcg ccttgaaaat atcccagtct gacttcgatt 3485401 cccacggagc cgagatcgca ggagcaaatg gatgaatgaa cggatgcata tctgtgctgc 3485461 tgagatcgtg tttttcatac catgtcgccg ccggcagcac gatatcggaa tacagcgccg 3485521 tacccgccat tcgaaaatca agattgatta ataagtcgag ctttccttcc ggcgcctgct 3485581 cccgccattt gatttcttct gggcggatgc tgtcgctgtc gtcattcatt aaaccgttcg 3485641 ttgtccccag caaatgcttg agaaaatatt catgcccttt tcctgagctt gagatcagat 3485701 ttgcccgcca tacaaagaga ttccttggga aattcacttc attgtcagga tcttcaatcg 3485761 cgaatttcag ttttttctct tggagctgtg aggccacgta cgcacctacg tcttcaggtg 3485821 ttgctgcccc tgctttttca gcttctttat acagatcgat gccattttga ttgaaagtcg 3485881 ggtaagacgg aagccaccct agccgcgccg ccagcacatt gtaatcagcg tggtgcttgt 3485941 agcgggatga agcagcaatc ggtgatgcca aatcactgat cggctggtcc tcataacgcc 3486001 actgatctgt cgcaaagtag aaaaatgagg tgccattttg cagcttgggc acgccttccc 3486061 agtcctttgc agttgcaatc gtctgccacc cttcagcagg tcggagcttt tcctgcccca 3486121 cgtaatgggc ccagcctccg ccgtttacgc cttgggcgcc tacaagtaaa acaagattta 3486181 acactgctcg gtagatcgtg tcggagttga accagtggtt aatgccggcc cctacgataa 3486241 tcatggaccg gccgtctgta tcgatcgcat tttgggcaaa ctctctggca atcttaacga 3486301 cagcttcttt tttgattcct gtcatttgtt cctgccaggc aggcgtaaac ggctcagggt 3486361 catcatagga gacagccgat cgttcgccga tgccccggtt cacgccgtag ttagccagta 3486421 tcaagtcaaa cacggtcgtg atgtacgttt cttcaccgtt caggttcatt tttttaatag 3486481 gaagatcccg ctcgagcact ttgtttccgt catttgaaaa atacgggatg cgcaccgtgc 3486541 cgatttcgtc ctctattccc agcacagaga gacggggttc aatcggttcc ccggtttctt 3486601 catcaatcat gtgcaggttc catttctgct gcccgtccca gcgcgagccc attgtccctt 3486661 ggggtatggc aaatgaactt gtctgttcat cccaaaccgc aggcttccac tgatcatgct 3486721 ttgtcttccg cccgatgtcc ttcgcatgca gaaaccgtcc cgctgtgtat acgccatttt 3486781 cttttgacag agtgacgaga aatggaaaat cagtgtattg cttcgcgtac tcaataaaac 3486841 gttcagtttc ttggttcacg taaaattcct gcagaataac gtgacccatc gccatcgcaa 3486901 gcgccccgtc agtcccttgg cgaatactca gccagtcatc cgcgaacttt gaggattccg 3486961 caaaatctgg actgatcgaa atgaccttag cgcctttata gcgggcctcc gccaaaaaat 3487021 gcgcgtcagg cgttctcgtt aacggaacgt tggagcccca tgtgataata tagccggaat 3487081 tgtaccaatc actgctttcc ggaacgtccg tctggtcacc ccaaatttgc ggggatgctg 3487141 gaggaagatc cgcataccag tcataaaaac tgagcatagg gcctccgatt aacgacataa 3487201 accgggagcc tgatgcgtgg ctgatcatgg acatggccgg aatcggagaa aaaccgacgt 3487261 ttcggtcagg cccgtatttc atcactgtat acagcagaga ggctgaaatc agcttcagca 3487321 cctccggcca ttcagcgcgc acaaaaccgc ctttccctct cgcctgttta taggacttcg 3487381 ctttttcagg gttttcgacg atcgatttcc aggcttccaa tggattttga tgcgtctgca 3487441 atgcctcccg ccacaaattg atcagcacac cgcgcacgta tggatatttc acacggagcg 3487501 ggctgtagat ataccatgaa aaactggccc cccgcgggca gcctctcggt tcaaaatcag 3487561 gcatatccgg gcctgttgat ggataattca aattttgccc ttcccacgtg actattccgt 3487621 ttttcacata aatattccag ctgcaagacc ctgtacagtt gacgccgtgg gtggagcgaa 3487681 cgactttgtc gtactgccat ctgtttctgt atacattctc ccaatcgcga tcctcgcggg 3487741 tagtttggct atgtttattt gaatggtgtt cgataggaga gaaataattc aatctcctaa 3487801 acaacggact ccttttcttt ttcttcatga gagttcactc cttccgagtc aggtgatgct 3487861 aagttcacta taaacagaga cagcgtgttt ccttgtgaac tatgtcacac actctgcttt 3487921 tttcacaaaa tgttcacaca aaggagaagg aaggctgcgt tcaggcagga cgcttgggtc 3487981 attagctgcc tttcattcaa agatcaaaaa aaaccggctc tatttaagaa ccgggctcag 3488041 cgttttcatc ctgtgatgta tgcagatacc gcaaaaataa ttgataggaa caaaaaacat 3488101 tttgctgaag catagccaaa aagttcattt gcagctgcgg atgataagac atcattttct 3488161 taaatatgta atatgggatg ttgagaatca gaatgtctga agtggcattg actgagataa 3488221 agggcgataa ataaagcccg cctttttcat caatcggaaa cacatcgcct ttttcccaca 3488281 gcgcaacggt tttcgaccct tcagggagcc ttgtgtccat aaaacggaca ctgcctttta 3488341 atacaatata aacagattga gaatgaagaa aagatggaga ctgatcacat gaaccgcgga 3488401 taaacgtgcc gtttttcagc aaggtttcga caatggatag aggcacttca ttaaacatag 3488461 gaagttgttt cagaaataat aaatagtcac actgattcat aggaaaacct cctgtgctaa 3488521 ggatagcttt agtgtagctc gactgagcct gtacagcagt gatgtatttc acagcctgta 3488581 tgatgaatgt cacttatcag gagggtgaat gcatttataa tgaaagaaaa aaggaggatt 3488641 tcgatgaagg cgctgattcc gaagcagcac ggggcgtggg cgatgctgct gatcccattt 3488701 ttactcggca tggtcaaggg aggccccgtt atttggcata ttccgctctt ccttggttgg 3488761 cttttcctat acttagcggt ttatcccgtt acgcttgcct taaaaaagaa acaaagcaaa 3488821 ccatatcaaa agtggatgtg ttattacggt tttcccacct gctgcttttt gatgatctcg 3488881 gtctttcata agccgcctct catctgggtg ggcgtttctt tactgccgct gtttctcata 3488941 catatgtatt ttgcccgcag aaaaaacgaa cgagccttat tgaatgatgt tgcaggtgtc 3489001 ttgttctttt gttcgggcgg gtttgcgagc tgctggctgg ggatgggaac ccttgacggc 3489061 tgggcttggt ttattttctt gcagtctgct ttatttttta tcgggagttc cttttatgtg 3489121 aaatcggtga tccgcgagag aaaaaacagg gcatttgcat actggtcatg gggatatcac 3489181 ctgctgctcc cctttttatc cgctcttttc ggagcaggat gggcgtttct cgcttttatc 3489241 ccgagcagct tgcgggcatg gttttttcat ggaagggatt ggcccgtaaa aacgattggc 3489301 attctggaaa tcgtgaatgc ctgcttcttt cttgccgtca tgtgcctgtt tatcacaagg 3489361 taaaaaaaca aggacaccgc tgtccttgtt tttttcagtc aatattgcaa atctccagcg 3489421 ggcaattttc acactcaatc tcacatcgta aatagtcccg cttgtgcaaa ataatttttc 3489481 cggattcgtc tatcgaaata accccttttt tgcggagatc tccgagcata cgattgacgc 3489541 tttcccgtgc agccgcgcaa aactttgcca aatcctgatt tgtcaggaca atgttaatca 3489601 gaatgccgtc gcttcgctcc actccgtagc tgtttgataa gcggataagg gtagaataga 3489661 gcgccccctt tttgccatga agaagcagat ccctgatttt ggactgaatc ttccggaggt 3489721 gcgtgctcat ccatttcatg aactcaaatg tcaaagcgcc gttttggatt aattcttttt 3489781 ccagcttatt tttattaatg acgagcacct cgccatcctc tagtactttt gcactgagca 3489841 tataccttgg ttcttcagtg aaaagtgtta attctccgac gatatcatgc ttttggcaga 3489901 ttctaagcgt caggtctttt ccgtcagatg tcagcttgcc gatttcaatg agtcctgatt 3489961 gaatcagata aagctcttct gcatccattc cttcccgaaa caaatacgtg tgtttttcca 3490021 tttttctttt cgtgctgatc gattccagca attcatacag atcgctggat ataagatcac 3490081 tatcagatgg tcgaacagag agaaaattca tgagctcacc tcgaagaaag tcacgttgtg 3490141 tgtttattgt aacgtgaatt gatttgtacc catcgagaaa aaactaacaa tcttgtgaat 3490201 gccccagtgt tagttgatgc tctggctgtt tctctccgtg tgtgttttca ttctttcctg 3490261 ccaatacatc catatgacaa ggacaaaact ggctaacgcc acctctgaaa gcgccataaa 3490321 cccgatcgcg tactggcctg ttgcctgaaa tacactcgcc aatatgagcg gaggaaaaaa 3490381 gccgcctaaa ccgcccatgg cagacacaat cccattggca atccccgctt gcttcgaaaa 3490441 atagaaaggc accagtttaa aaacagttcc gtttcctatg cctgagcaga cggccacggt 3490501 taatgatcca aacgtataaa ggccgattgt cggcgagaac gataggataa tgcctgataa 3490561 tgtaagcccg gcaaaaacaa acatcaagat gcggagcggg ctcattttat cagccaggaa 3490621 tccgcccgca ggcctgagca gcgtagaaac cgcaataaag ccagccgtcc gcaagccggc 3490681 atctgcagga ttcagcccaa aatgctccac cagaaagttc ggcagataga tagtgaaggc 3490741 gacaaaggca ccgaacgtaa taaaataaaa caggctcaga aaccatagca catgatttcg 3490801 gtaaacagct ttgatttgag tcttaacaga aactttgacc ttcttctcat gcctgtcgcc 3490861 aaacaatacg tgcagtaagg caaagacagc cagcaaaatc agatacattt gcacggttga 3490921 tttccacccg acggcttgag cgataaccgg cgctgcaaat gtcgtaacgg ctgtcccgat 3490981 atttcctgca ccgtaaatcc cattgacgac accgtgcttt tctttcggat aatatttcgg 3491041 gagggaggtc accccaatgg aaaacaccgc tcccccgatc cctaagaaaa agccgcctgc 3491101 gattaaatca aacagagaat ccgcgatact gatccaaaat acaggaaata aaagcaggat 3491161 gaagctgacc ataaacatga gccgcgcgcc aaacctgttc gttaaatacc ctaaaggaat 3491221 gcggagaagc gacccgagga tcacaggaat cgcggtcact aaagaaatct cacccttgct 3491281 taaatgaata tctaatgtga tttgggaaat gagtgatgaa atcagcaccc aaaccataaa 3491341 ccctgccacc aagcttaatg actgtaacga taattgaatg tgttgacggt tgatcatttg 3491401 gcttgcccct ttcaatgatt caataatcag tcttatcata caaaaactag ccaaacagga 3491461 ttgtgaatta catcacacgt ttttctcata aaaaaaggac aaagcccgaa gactttgtcc 3491521 ttttgatcgt gattacattt tttccggagc cgatacgccg atcagctgaa gcgcattgtt 3491581 cagcgtaatt tgcgttgcct tcattaaagc caggcgcgcg cggcttttct cttcattttc 3491641 agggtcgatg actttctctg cgttgtagaa gctgtgcaga gcagaagcca gatcataaat 3491701 atagttagtg acacggtgcg gaattcgttt ttccgctgct tccgccactg cctctgggaa 3491761 gccgccgatc gttttcagca gatcgtattc tttttctgat tgaatatggc tgaaatcaag 3491821 atctgccgcc ggtttaagcc cctgctcttc cccttggcga agcatgctgc aaatacgggc 3491881 atgcgcgtat tgtgcataat acacagggtt ttcgttagat gttgatacag caagatctaa 3491941 gtcaaaatcc atatgggtgt ctgcacttcg cattgcaaag aagtaacgca cggcatccaa 3492001 gccgacttct tcaatcaggt cacgcatcgt tacggcttta ccggtccgtt tgctcatttt 3492061 cattttctcg ccgtttttgt aaaggtgaac gagctgaatg atttctactt caagcgttcc 3492121 tttttcatag cccagcgctt cgattgccgc tttcatacgc gggatgtagc cgtggtgatc 3492181 ggcgccccaa acgttgatca gcttatcaaa gccgcggtca agcttgtcct tatgatacgc 3492241 gatatcagga agaaggtacg tgtacgtgcc gtccttcttg atcaatacgc ggtctttatc 3492301 atcgccgaaa gtcgtggaac ggaaccaagt cgcgccgtct tcttcataga cgtggccttt 3492361 ttcgcggagc gcttcaagcg ccttgtcgat ttttccattt tggtacagtg aagtttctga 3492421 ataccacaca tcaaacggca cacggaagtt ttccaagtcc ttgcgaagct tttccagctc 3492481 gtatttcagg ccgtattcac ggaaaaacgc gaggcgttca ctttcctctt cgttaacgaa 3492541 acgatcaccg tattcctcag cgagacgctt tccgatcgca atgatatcct caccgcggta 3492601 gccatcctcc ggcatcggtt tttccaatcc gagtgcttca aagtaacgga cttcaacaga 3492661 aagcgccaga ttgttgattt ggtttcccgc atcgttaatg tagtattcgc ggcttacatc 3492721 gtaacccgct tttgaaagca cgttgcacaa ggaatcgccg acagccgccc cgcgcgcatg 3492781 cccgaggtga aggtctcccg tcggattcgc tgatacgaat tctacctgaa ctcgttcacc 3492841 gtttccgatg ttcgtttccc cgtatgcttc ccctgcttcc agtacagacg gaatcagctt 3492901 tgttaaatat tgattgttca tatagaaatt gataaaaccc gggccggcga tatccagttt 3492961 ttcaatcgaa gccttccctt tatcaaaatg ggcgacaatc tcttcagcga tttgacgcgg 3493021 cgcttttttt gccactcttg ccaactgcat cgccatattc gttgagtagt cgccgtgtgt 3493081 tttatctttc ggtgtttcta aaacaacatt gggaatctgg ctttcttcag ccagtcccgc 3493141 tttcagaacg gccgctttga tttcttcttt cagcacgtcc ttcatttgtt ccgcaatgtt 3493201 catgcgtgag ttcctccctc atacgtgatc gtcatattat gtaaatgctc ctgctcgtct 3493261 ccgacatgca tgtcatatgc gatgctgata cggccttttt cttcatcgag atcagattga 3493321 atcgattttg tgcttgtttt cagctcaagc tcaccaaatg acattttata tttagcaatt 3493381 gtggaagctc ccgttacgaa acgctgattc attttgacag cgcctgacct catgaccagg 3493441 acttcgcctt cgcttacttt cacaatcgtt ttgactttgc ctaagtcgtg ttcttcataa 3493501 taagatagat acactttatt ttgttttaca tagtaaaatc cggtggtgcg gaattcgatg 3493561 acttcttggt ttccgtcatc ctcgatcaca gacttcacat ggagtgttat cggtgtctct 3493621 tgcttcattc tgacacgtcc ttttcatcat tccactttga cttgaatagt ataatcattc 3493681 ggtttgtaaa cttcaactgc ttctatctta ccatcattgc tcatcagatt tgaagataaa 3493741 cctcataaaa agcatttcct tatatagaag agaaaatcat atcactaatt acctttagga 3493801 aatgttacat ttttccgaaa tctatcattt ccttttcaca tttttttcaa aatatatgta 3493861 ttgaattagt aatttgatag ttttaagata aaagtacaac atagatctgc tagaaaaaca 3493921 aaaaaaggga ggattcaatt atgaaaaaag ctgtcattgt agaaaacaaa ggttgtgcaa 3493981 catgctcgat cggagccgct tgtctagtgg acggtcctat ccctgatttt gaaattgccg 3494041 gtgcaacagg tctattcggt ctatgggggt aaggatctcc caaaagggca tagtcattct 3494101 actatgccct ttttaagtaa attacaattt ttaactaaaa tctacctctt ggatatacat 3494161 acacaaccgt ttttcatttg aatcatatgt ataggggatg gtattttgtt tatagagcag 3494221 atgtttccat ttattaatga aagtgtaaga gttcaccagc ttcctgaggg cggcgtgtta 3494281 gaaatcgact acttgcgcga taatgtctcc atttctgact ttgagtattt ggatctcaac 3494341 aaaacggctt acgagctctg catgcgcatg gatggccaaa aaacagctga gcagatttta 3494401 gctgagcaat gtgcagtgta tgatgaatca ccggaagacc ataaagattg gtattacgac 3494461 atgctcaaca tgctccagaa caagcaggtt attcagcttg gaaaccgggc cagccgccat 3494521 acaatcacca cgagcggaag caatgaattt ccgatgcccc tgcacgccac ctttgaactg 3494581 acgcaccgct gtaatttgaa atgcgcccac tgttatttgg aaagctcacc tgaagcgctc 3494641 ggcaccgtgt cgattgagca attcaaaaaa acggctgata tgctgtttga taacggtgta 3494701 ttgacatgcg aaatcacagg tggagaaatt tttgtccatc caaacgccaa tgagattctt 3494761 gactatgtgt gtaaaaagtt caaaaaagtc gctgtcttaa caaacggaac actcatgcga 3494821 aaagagagcc tggagctttt gaagacttac aagcaaaaaa tcatcgtcgg catttctcta 3494881 gatagtgtca attccgaggt ccatgactcc tttagaggga gaaaaggctc ttttgcccaa 3494941 acttgtaaaa cgataaaatt gttgagtgac cacggtatat ttgtcagagt cgctatgtct 3495001 gtcttcgaaa aaaacatgtg ggaaatccac gatatggccc aaaaggttcg ggatctcggg 3495061 gcgaaggcgt tttcttacaa ttgggttgac gatttcggaa gaggcaggga tattgtccat 3495121 ccaacgaaag acgccgagca gcaccgcaag tttatggaat acgagcaaca tgtgattgat 3495181 gagtttaaag atctgattcc gattattccc tatgagagaa aacgcgcggc aaattgcggc 3495241 gctggctgga agtccattgt gatcagtccg ttcggcgaag tacgtccttg cgccctcttt 3495301 ccaaaggaat tttcattggg aaatattttt catgattcct atgaaagcat ctttaactcc 3495361 cctctcgtcc ataaactgtg gcaagcgcaa gcgccgcggt tcagcgaaca ttgcatgaaa 3495421 gacaaatgcc cgttcagcgg ctattgcgga ggctgttact taaaagggct gaactctaac 3495481 aaatatcacc ggaaaaacat ttgctcttgg gcgaaaaatg aacaattaga agacgtggtc 3495541 cagcttattt aggagggaaa cgatttgtca ccagcacaaa gaagaatttt actgtatatc 3495601 ctttcattta tctttgtcat cggcgcagtc gtctattttg tcaaaagcga ttatctgttt 3495661 acgctgattt tcattgccat tgccattctg ttcgggatgc gcgcgcggaa ggctgactcg 3495721 cgatgagcat tttggatata cacgatgtat ccgtttggta tgaacgggac aacgtcatct 3495781 tagaacaagt ggatttacat ttagaaaaag gcgccgttta cgggttactt ggggtaaacg 3495841 gcgccggaaa aacgacactg attaatacgc tgacaggcgt gaaccgcaat ttcagcgggc 3495901 gttttacact gtgcggaatt gaagcggagg ccggcatgcc gcagaaaaca tcagatcagc 3495961 tgaagactca ccgttacttc gccgccgatt atccgctgct atttacagaa attacggcga 3496021 aggactatgt gtctttcgtc cattcgcttt atcaaaagga tttttcagag cagcagtttg 3496081 ccagtttggc cgaggccttt catttttcga aatacatcaa taggagaatt tcggagctgt 3496141 ccttggggaa caggcaaaag gttgtattga tgacaggctt attgctgcgc gctcccctgt 3496201 ttattttgga tgagccgctc gtcggtttgg atgtggaatc gatagaggtc ttttatcaga 3496261 aaatgcgtga gtactgtgaa gcaggcggaa ccattttgtt ttcttctcat ctgctcgatg 3496321 tcgtgcaaag attttgtgat tatgcggcta ttcttcacaa caaacagatc caaaaggtca 3496381 ttccgattgg agaggagacc gatctgcggc gggaattttt cgaggtgatc ggccatgaat 3496441 aacataatcc ctatcatgtc tttgctgttc aaacagcttt acagccggca agggaaaaag 3496501 gacgccatcc gcattgccgc aggccttgtc attctggccg tgtttgaaat cgggctgatc 3496561 cgccaggccg gcattgatga atcggtgttg cgcaaaacgt atatcatact cgcgcttctt 3496621 ttgatgaaca catatatggt gtttctttcc gtgacatcac aatggaagga atcttatatg 3496681 aagctgagct gcctgctgcc gatttcttca cggagctttt ggctcgccca gagtgtcgtt 3496741 ttgtttgtcg atacctgttt gagaagaact ttattctttt ttattttacc gctgttctta 3496801 tttggaaacg gaacgctgtc aggggcgcaa acattgtttt ggctcggcag gttttcgttt 3496861 tttaccgttt actccattat tttcggagtt gtgctaagca accacttcgt caaaaagaag 3496921 aacttgatgt ttctgctgca tgcggcgata ttcgcctgtg tatgtatcag cgccgctttg 3496981 atgccggccg ccacgattcc gctttgcgcg gttcatatcc tgtgggcggt ggtcattgac 3497041 tttcctgtct ttctgcaggc gcctccgcag cagggcaaga tgcattcatt tatgcggcga 3497101 tctgaatttt cgttttacaa aagagaatgg aaccgattta tctcttctaa agcgatgctg 3497161 ttaaattacg cggtaatggc ggtattcagc ggcttctttt cgttccagat gatgaacacc 3497221 ggcatcttca atcagcaagt gatttatatc gtgatttccg cgcttttgct catctgctcg 3497281 ccgatcgccc ttttgtattc gattgaaaaa aatgaccgga tgctgctcat cacgcttccg 3497341 atcaagcgaa aaacgatgtt ttgggcgaaa tatcgctttt attcaggcct attggcaggc 3497401 ggatttctcc ttgtcgtgat gattgtgggt ttcatcagcg gccgttcgat ttcagttctc 3497461 acttttttgc agtgcattga gttgctgctg gcgggagcgt atatcaggtt aactgcggat 3497521 gaaaaaaggc cctccttcag ctggcagacg gagcagcagc tatggagcgg tttctcaaaa 3497581 tatcggtctt atctgttttg tcttccccta ttcttagcca tattagccgg caccgctgta 3497641 tccttggcgg tcattccgat agccggtctg gtcatagtct attacctgca aaaacaggat 3497701 ggtggtttct ttgatacaag caaaagagaa cggcttggaa gttaacctgc tgaagactca 3497761 tcaattttca actatttcaa tcgccgcgag ctttctgaaa ccgatcgaaa gcgcggcgga 3497821 acctgaggaa gaaacgattt atttttacgg cgccgccgca tacctgaagg agcaaatcat 3497881 tgacgctttt ggttatgctg ccggcagccg tttcatgtac tcagcgaatc tcttttttga 3497941 tcagcagctg aaaacctgcg ggacccgttt gattcaccca ttatataacg ggaatcttca 3498001 tgttgacgcc ctgatgaaaa cttttgcaga cttgtctttc ccttcttctc tttcattcga 3498061 agcatttgaa aaggccagga atgagctgct gctgaaaatc gaaaagaaat tcactgatcc 3498121 cttctcctac tcggcggctc gcttggctga ggaggtcttc ggaaacccga tgtacggcac 3498181 aggcatgttt ggccggagag acaggataaa ggcgattcat cctaaacggt ttctcgacgc 3498241 aacggacttt atcgttgatt tagtgtccca gcaaaaacag ctgaacatat tgggacaagt 3498301 acaagcatgt gatgttcggg gacatgcccc gcaaacgtcc gctgtaacgt ccggaagaat 3498361 acccgtaaac cggcatgttt ttgaaacaga gacacgcagc gctgcaggtc cttccgtctt 3498421 gacactcgga tttgactgcg gagagatgaa agatgccagc gattatatca aaatacagct 3498481 aatagacgga ttactgggaa agtacggcca ttccgcttta ttcaagcact tcagagagaa 3498541 ggatctggca gtctatcacg ttatcacccg ttacgatgtc atgaacaatt tgctgcttgt 3498601 ttcaatatgt acagatcagc ttcatgagaa agacattccc ccgcgcgttt tggaagctgt 3498661 ctcagctttt catacagatg agcgggaact agaacaggca aagcagtttt tacgcaatga 3498721 attgctgctg caattcgatt ctcccgaagg tctattggcc tatatggggg tcctgcgccg 3498781 cttctcctgc acgaaagaag ccttgctgga tggcatctca gcggttacat gccgtgatgt 3498841 attgcaattc atagcgacca tcaattatat cggagctcat gtagtaaggg gatgaagaga 3498901 tggaaaagaa agcctttttt caacagctgg atgaacgaac cgatatcaga tacacagaca 3498961 gcggactaaa aatattcaga ttgaaattcc cccgcgccca cctgcggctg tgcaatgtaa 3499021 aaatcgattt tggaagccgg gatgtatgta tacgggcaga atccggtgat acactgcttc 3499081 cgtatggcac agcacatttt ttagagcatc ttctcttctg gcataacggc cgcaatctgt 3499141 acagtgattt ttttgcgcat ggcgcgcttt taaacgcatt cactacctac accgatacca 3499201 atttcatgtt tacctcatta ccggatcggc tcagacaaac gattcccatc ctgcttgatg 3499261 ctttatggaa ccactcattt gacaagaaga ttgtcgctca ggaaaaagct gtgattacaa 3499321 gcgaaattca aacagcacac cttaaccatc agctctcata tcattatcag ctgatcagca 3499381 tgctttctcc ctcctcacca gctgccgttt tccccgcagg cagaatcgaa gatattgagg 3499441 cgctggacat cagtgattta caaaaagcct ataaggctgc ctaccaagcc catcggatga 3499501 cgctgttttt gattgggggc tcagaaaata cagaaacgct tttgcctcct cacctccagc 3499561 tggaaaagcg tccggattat catgctgaaa gaaaaatcat cccggcatgc cctccagtcc 3499621 tctcacaaaa aatgatgctg ggtgatgagg agcggatgga agatacctgg accggattac 3499681 agatcggcgc acttcccggg caaaacgatc tgttgtcgat aaagctttat tgggatatcg 3499741 cggctcgtat tctatttcaa ttagattcac cgttttttca agagattcag caaacgtacc 3499801 gcctggaaat cgatcgcttg tcagccgaga cttatatata tgaggatggc ggtttcttga 3499861 tccttcacag tcaagggacc cattcttcag cttatatcga tgtggcttca tactatgtca 3499921 cacagaagaa agaacaggtt gccgcctggc ttcaatacgg caaggactct ttgacagacg 3499981 cgatcattta tgacagcgat tatgtgcgta aatgcttcga gtgggcagcc gagtgtgaca 3500041 ggtgcgattg ctcgtttctt gacatgtacc acatcattca agatatggat gcgcaggttt 3500101 tcttgtctct cattgatgca atggcatctt ctaacaaagc gatcattcac gtttctcaga 3500161 aagaggcgat cagacaatga aacaaagcac tgtctttacc cttttattgc tgcttatagg 3500221 tatggcggct tattccttcg gctgggttca ggccgttgcc gaagccgccg cccaatatgt 3500281 acagatgatc aacaatgatg ctgtgcggct cggactgctg gcttgtaccg ctgccctcct 3500341 gatgctgcct gcttttctct atcttcacta tgtcacccaa tccgtgaaaa acatgacagc 3500401 agcttttcag aaactcacac agtctcatca aagctgctgt gactttcagc aacacaactt 3500461 gtgcagccga tatgcagaag acgtcaaatc gctgcgtgac agctataaaa acgtccgcca 3500521 aacatacgtg atggctgccg tgttgtgcca agtcatcata ttcggctgca tgttcgaaat 3500581 cgttaaagcc gtccctttcc gccttcatac gccccctgcc ttttcaatgg gacttgcgat 3500641 gctactgatc ctgtatttat tgttttgcat gcgaacgtat ttgcggcagc ttttccggca 3500701 cggcagcctg ttcagaaaag tgtttgcggg agcactggca gcagccggga tttggtggat 3500761 gctcagtttc tctataagtg aactgctgtt tctgattatc ctggctgcca ttcagcaaat 3500821 cggatcattt atttataaac gattctctta tcacagcacc gcttctcttg atctataaaa 3500881 tagctacatc gcaatcgcag acggacccgc gccaaccgga atcaccgtca cggctgtata 3500941 atcacttgtg cggtacacgg tcacagcatt gtcgttgggc tgtgccgcat aaatatactg 3501001 tttgtccggc gttacggcga ggtcaaaggc gccggggaga gacacgtttg caatgatcct 3501061 ctgtctggcc gtattaacta cgtataagtt attaatgaga aacggttcac tatatggctc 3501121 tagaaaataa gctctagtac tatcgagaga aaatacaatc gtcctcagcg tttcaaataa 3501181 acggctgaag tcccctcccc tgcttaatgg tgacaaacta atctccgtta cacctttcgg 3501241 ccacagctca ccattcaata cgtacgcaaa atttccagcg taaggagttg taattaaact 3501301 gggaaattca aatgtatcta tgatactttc taccaactgc ccagtattta catcatattt 3501361 atcaaccgac caactgcttc cattagcggt atagacatac tgtccattcg gatcaagagc 3501421 aaagtctaaa gcgccgggta tcggaatgac atcaatgacc gattgagagg ccgtgttaat 3501481 cacatatata gatccggcgg ccatcacgta tgcgaactca tctgttggat caaattcgat 3501541 ttttctcggc cctcctccaa cagtaatggt atttatgatg gttaatgttt tattatcaat 3501601 cactgagaca aggttggtat ttccatggag gacatacgtg aatgctttat cgaaagtaac 3501661 gcctagatta gttggcacgt cagaaaaagg gattgttttt acaacagtgt ttaaatctgc 3501721 atcaataacc gaaaccgtgc tgtctccagt attggcagta aacacatacg attgagggtc 3501781 tggtgatggc ggtaaaacaa gtgtcccggc caccgtaagc ggactgccgt agaaaggcgg 3501841 tacaatgagc agatcttcca ctgttatttg actgaaatca ggacagcggc cagactgtgc 3501901 tgcataataa acaacttgat caatctcttc agtatgaatc acagaaacag ccccgtctcc 3501961 ttgtccatat tgatttcgta caggcgacac actgacaaga agcgtaatgg tcccttgtac 3502021 tctcacagca tatcgaacac cgatatcttc tggttccggc ccagtctgga ttaagcaagg 3502081 ctcactgata caggacaaat tgtctgtact ccatgtaaca gccgctgacg cttcggccgt 3502141 atcaaccttg aagccctcag ggaaatctat cggcacttga aacggcgctt cccggctaat 3502201 ttcctcatca caaaaacaga aacaattttc ctgtaaagca gaaagatcat tctttttcat 3502261 gatttcacgt ccttttagaa atgcacaaca tgcagcggtt aaatcgtaat ggcacccggt 3502321 gaaaccccaa gagatatcac agtttcctca gaataatcat ctgtgttgta aacaatgatg 3502381 ctctgctcta taaaacgagt tgcatacaga aaatcgccat tcggggtaaa cgcatagtct 3502441 gttgctgatt gcggaacatt tcctataacg cctgctccat ttggactgac agaatataaa 3502501 ttgccagtga agccgtcata taaatacacc tctgctccac tcgtaaacat tcgatattcc 3502561 ccttcatact ccagctcttg ggtgctgctg atggtaaacg tatttaaatc aataaccgtc 3502621 aaataattaa aaaagaattc ttgttctaat acataggcat accgctccgg ccaatttgtt 3502681 tctatggttg atacgataag ctctcgttca attgttcctg tgacttcacc ggtagttagg 3502741 tccacttttt gcactattcc aaaattcaga acataggcga ataacccatt gggatcgatt 3502801 gcaacatcat atccttccac aggaatcgac ctatccacag ttaacgtatc aattccaatc 3502861 acataaaccg cagtaccggt gaaaacataa gcaaactcat gattagggat aaatctaatc 3502921 aatcgaggcg gctgatccag caatatagtt gctgtcactg ttaatgtgtc ataatcgatg 3502981 acagaaatca cattattgtt gggatgtaag acaaacacag cgcttttatc tggcgtaatt 3503041 tcaatacctg ccggattgta cggaagagca atcgttgtca caacagtatc ggtgtttgta 3503101 tcaatcacag aaactgattg atcatttgga ttcgctgtaa acgcgtagac gggttccggc 3503161 tccggtacaa gcacaattgt ccccgtcacc gataaaggac tgccgtaaaa cggcggaaca 3503221 acaacaaggt tctcaatcgt gatgtcactg atatccgggc aatcatccga ttcatcggaa 3503281 taatagacga cttgatcgat ttctgcattg tgaatgacgg aaacagcccc gtccccttgt 3503341 ccatattgat ttcggacagg tgagacactg acgagtagcg taacggttcc ctgcaggcgc 3503401 actgcaaatt gaacaccgac ctcatcaggc tcaggccccg tttgaattaa gcaacggtca 3503461 ctgacacaag aaaggctgtc tgcattccac gtcacgtttg caacagcttc agccggatca 3503521 acgacaaacc cttcaggtaa ttcaatcggt gcttgaaaca tggcttctcg gcttgcttct 3503581 ccctcacaaa aacataagca ctcttcttgt tctgctcctg ctttttcttt aaaggaaagc 3503641 ttgttttttc tcattccttc acttcctttt cagacataca ctgctcacgc agatataaca 3503701 gaatatggaa gggtaacgtg tttgcttgta caaattgctg agggtaaacg cttctttttg 3503761 aaaatatatc tccaaacatg cggtgtaacg aaagaaaaaa ttgcggtttt tttgcgcttc 3503821 tcacaagaat gttgatgata aaatatgaca tatatagaat tatgaaggga gggatttgca 3503881 aacgtgacag gtgtcatatc ttcttcttcc atcggagaaa agattaacga atggtatatg 3503941 tacatacgcc gattcagcat acccgatgca gaatatttgc gacgagaaat caagcaagag 3504001 ctggatcaaa tggaagaaga tcaagacctt catttgtact attcactgat ggagtttcgg 3504061 cacaacctaa tgcttgagta ccttgaaccg ttagaaaaaa tgaggattga ggaacagccg 3504121 agactgtctg atctgctgct tgagattgat aaaaaacagg ctcgtttaac tggtctgctt 3504181 gagtactatt ttaacttctt cagaggcatg tacgagctgg accagcggga atatctgtcg 3504241 gctattaaat ttttcaaaaa ggccgaaagc aagctgatat tcgttaagga tcggatagag 3504301 aaagctgagt ttttctttaa gatgtctgaa tcttattact atatgaaaca aacgtatttt 3504361 tcaatggact atgcacggca agcatatgaa atatacaaag aacatgaagc ttataatata 3504421 agattgctgc agtgtcattc tttatttgcc accaattttt tagatttaaa acagtatgag 3504481 gatgccatct cacattttca aaaagcttat tctatggcag aagctgaaaa gcagccccaa 3504541 ttaatgggga gaactttgta caatatcggg ctttgtaaaa acagccaaag ccaatatgag 3504601 gatgccatac cttatttcaa aagagcaata gctgtttttg aagaatcaaa tattcttcct 3504661 tccttacctc aagcgtattt tttaattaca cagatccatt ataaattagg aaaaatagat 3504721 aaagctcatg aatatcatag taagggaatg gcttattcac aaaaggccgg agatgtaata 3504781 tatttatcag agtttgaatt tttgaaatct ttatacttat caggcccgga tgaagaagca 3504841 attcaaggat tttttgattt tctcgaaagt aaaatgttgt atgctgatct tgaagatttc 3504901 gctattgatg tggcaaaata ttatcatgaa cgtaaaaatt ttcaaaaagc ttctgcttat 3504961 tttttgaagg tggaacaagt aaggcaactt attcaaggag gagtgagttt gtatgaaatt 3505021 gaagtctaaa ctattactct cttgtctggc tctaagcact gtgttcgtgg caacaactat 3505081 tgcaaatgca cctacacacc aaattgaagt tgcacaacga ggaatgattt aaccgccgtc 3505141 catcggcggt tttttcgtcc cctctttacc aaagtctccc aatccatgct atgatctttt 3505201 caataatctt gaagagagtg gaaatgcagc atgtctctaa aaagtgtgag aacccacttt 3505261 actcaatgga atcgagaaaa tgatgtgacg gagttcgaaa cgtcgagtgc gacagttgaa 3505321 caggcagctg agacaatcgg cgtaagcctg tctagaatcg ccaagtccct gtccttcaga 3505381 ggggaaggag atcaggtgat tctgattgtg gcagccggcg atgccaagat cgacaacaaa 3505441 aagtccaggc aaacatttgg ctttaaagca agaatgctct ctcctaatga ggtgctggag 3505501 cagacaggcc atgaaattgg aggagtttgc ccatttggat tggctcatga tcctgaggtt 3505561 tatcttgatg tatcgctgaa acggtttcag actgttttcc ccgcatgcgg cagcagaaac 3505621 tccgctattg aattaacacc gaaagaatta tccgaatttt ctttctcaaa agtgtggatt 3505681 gatgtttgta aagactggga ataaaaaaac atccagacat cgtctggatg tttacttatt 3505741 tcacaaaccc aagcagcatt tcacggatga ttttgctggc tgtgtttgcc gtttgctctg 3505801 agtggtcgta taccggcgcg acttccacta aatcagcgcc ctttacgttt acctctgaac 3505861 gcgcaatttc atggaccgat gcaagcagtt ctttagacgt gatgccgccg gcgtcaaccg 3505921 ttcctgtacc cggtgcgtgt gcagggtcta atacgtcaat gtcaattgtg acataaaccg 3505981 gacggcccgc cagcttcgga agcacctctt tcagcggttc aagcacttca aattttgaga 3506041 tgtgcatgcc gttttccttc gcccattcaa actcttcttt catgccggaa cggattccga 3506101 atgaatacac attgtgcggt ccgatcaatt ctgccgcctt acggatcggc gtggagtgag 3506161 aaagcggttc tccctcataa tcaacacgaa gatctgtatg tgcgtcaaaa tggataatcg 3506221 caaggtctgg gtatttcttg tacatcgctt taatgacagg ccatgacacg aggtgctccc 3506281 cgcccatacc cattgggaac ttcccttttt ctaaaatgct gtccacgtac tcttcaatca 3506341 tatccaggct tcgctgcgga tttccgaacg gcagcggaat gtcgccagcg tcaaagaagt 3506401 tcaagtcagc cagatcgcgg tctaaatatg ggctgtattc ctcaaggccg attgacacct 3506461 cacggattct gcttggacca aagcgtgagc ccgggcgata gctgactgtc cagtccatcg 3506521 gcatgccgta aagaatggcg tccgcctctt cccactcggg acggctcgcg ataaatactt 3506581 ttcctgaata agcttcatca aatctcatct ataataccct cgctttcctg taaaaaagcg 3506641 caagattcgc tcctgcgcca taccttcatt atttaatcag gtcactcaca aatttcggca 3506701 gaacaaacgc cgctttatga atatcttttg tgtaatattt cgtctcaata tcgaagaaac 3506761 ggctgtcttc cactgcaagc ggatcatatt ttttcgagcc aattgtaaat gtccacaaac 3506821 cgcttggata tgtcggaatg ttcgccgtat acagcttcgt aatcgggaag atttccttca 3506881 cgtcgcgctg tacatttgtg attaattccg gtgtaaacca tgggttgtcc gtctgcgcaa 3506941 cgaaaatacc gtcttctttc agcgcttttg cgattcctgc gtagaatcct tttgtaaaca 3507001 ggtttacagc cggtccgact ggttcagtcg aatctaccat gatgacgtca tattgatttt 3507061 cagattttgc aatgtgcata aatccgtcat ctacctgcac gtcaacgcgc ggatcatcca 3507121 gtttgcctgc gatagaagga aggaactttt tagagtattc gataaccttg ccgtcaatat 3507181 ctacaagtgt cgcttttttc acgcttgggt gcttcaggat ttctctgata acgccgccgt 3507241 caccgccgcc gactacgaga acgtgctccg gatttgggtg cgtgaataat gggacatgcg 3507301 ccaccatttc gtgataaacg aattcgtctt tttcagatgt catcaccatg ccgtccaaaa 3507361 aaagcatgtt gccgaactct tctgtttcca ccatttctaa atgctgaaac tccgtttgtt 3507421 ctgtatgtaa cgtcttgtta accttcatcg taatgccaaa gtttttcgtc tgcttctctg 3507481 tgtaccaaag ttcgctcaat tgtcatctcc ctttcgaggc tgtattcatt tattgtaagc 3507541 gtcttatcag cttttattct cggttgaaat ctcattttca cctaaggaaa aagtatagag 3507601 gatggcgggg aaaaagtaaa gatgcgtcct gttctgcgat gtttaaaaac gatctttttt 3507661 tctcataata gtagaaacat aaaaaaaggg ggaacccgtt gtggatgcaa tgacaaataa 3507721 acggctgaga ctgacgctga aaaccgttcg cgcctttatc tttttagggg cttttgcggc 3507781 cttggcggca gctgctgtgt ttatgactgt cattttgata gccaaatacc agggcgctcc 3507841 ctcggtgcaa gtgccgcaat ccacgatttt gtacgcgagt gacggctcaa agctcgggga 3507901 aacgaactac ggcgaaaagc gctattgggt ccccttaaag gacatgaatc cgacgatcgt 3507961 aaaagcgaca gtggcgattg aagaccagaa tttctacgat catcacggct ttgattataa 3508021 acgcatggcc ggcgcggcgc ttgctgacct gaaagcattt gccaaggttc agggtgcaag 3508081 caccatcacc cagcaatatg cgagaaactt ataccttgaa cacgacaaaa cgtggaaacg 3508141 gaaatggaat gaggcgttct acacgatccg tctggaacaa aactattcta aggacgagat 3508201 attagaaggc tatttaaata cgatttacta cggccacggc gcctacggca ttgaagcagc 3508261 ttcccgcctg tatttcggca agcatgccaa aaacctgacg gatgcggagg cggcgctttt 3508321 ggcaggaatc ccgaaaggcc cttccggcta ttcaccgtat gtcaatgaga cgaaggccaa 3508381 ggaacgccag aaaacgattg tgcggatgat ggaaaagcag cagatgatca gccaaaagaa 3508441 agcggatgaa ttgatcaagg aacctctttc ctatcagcct ttgaataaac aagtttccaa 3508501 gagaaaggct ccttatttct acgacaatgc gatgagagag ctggaaaaaa agctcggcat 3508561 gacacgggag caaattgaaa cgagcgggtt aaacgtctat acaacggtag ataaacggat 3508621 gcagcgcatc gccgaggaga ccattaccga aacggttaac gcgggctctg acattcaagt 3508681 cgggttttca gccattgatc cccgcaccgg aaacgttctc gcccttgtcg gcggcaggga 3508741 ttatcaaaaa agcccgtttg accggacgac acaggcgaag cgccagcctg cttcgacgat 3508801 caagccgttg ctgtactata aagcgattca gagcggattt acgccagtca ctttgatgaa 3508861 aagcgaagaa accgagtttc aaattgatgc aaagggagaa acctattctc caagcaacta 3508921 taacggatac tatgccaaca agccgattac gcttctgcag gcgctggcgc tttccgacaa 3508981 tatttacgct gtgaaaacgc atctttttct cggcacgaac aaacttgtaa agacggcaaa 3509041 ggaattcggc attaccgccc atcttcaagc actgccgtcc ctggcactcg gcaccgaacc 3509101 cgtacgtccg attgagatgg tcaacgccta tgccatgctc gcaaatggcg gaaagaaaat 3509161 cgaaccgact tttatttcaa gagtaacgga cgcagccggc cacgtgctgt acgaaaaccc 3509221 gaatcagcat aaacaggtgc ttgatgaaaa agccgctttt gtcacagcga gtatgatgac 3509281 aggcatgttt gatatcgatt taaatggata tacgtcggtt acggggcgaa cgatagccaa 3509341 ccgcctgaca agaacgtatg ccggaaaatc aggaaccacc agcgcagaca gctggatgat 3509401 cggcttcaat ccgaagctgg ccgccggtgt ttggaccggc tatgacaaaa acagcaccat 3509461 cgactcggtc gaagaaaaaa gctatgctaa aaccatttgg gcggacttca tggaggacgc 3509521 gctcaaaggc gaaccggaaa ccgcgttcaa gccgccaaaa ggcgtaaccg gtgtgtacat 3509581 tgatccggaa acaggctact catcaggtcc cggctgcgcc gctaagcatt acacatattt 3509641 tgtgaaaggg acagaacccg caaacgtgtg ctacggggca gaacccgcaa aacaaacaaa 3509701 agaccggctt ccatccaaag aaaagcccgc ttccgagaaa aagtggtggg acaaatggct 3509761 ggggcgacat cattgaaaat aacccggctc ctcggaggcc gggttattcg tatggttcct 3509821 tcataatcga tggaagaatg ttagacaatc gagctgaaca atcagttttg ggataaagtg 3509881 gtgaatttct catttcttcg gcgctggctt tcatctccca gtcgccgact catatccccc 3509941 taaaaatgaa aaaccccgag tcttgtttcg gctcgggatt ttccatgtcc tatttctgta 3510001 tcaccagttt actcaatgtt tacgaaaaat atctcaaata ctttaaaagt tcacaaaaaa 3510061 ttcataaatt aattgttttc tggaagcagg ctcgttttta actcatctga ggaacggtcc 3510121 cataggccct gatcatgctt tttcagaaat tcgcctagta cacgcttcga gctgtcgtcc 3510181 attttatcaa cgatgatttt ccgtttcatg gatttatcca tcagattcac atgctcaggc 3510241 agtgacttgt agcctcttct gatgcttctg tcgaccgtca tttcacaggc tgtcacacca 3510301 gcgtaataag gcccctcttc ttttctgtca atcgttaccc acacaagcca gtatggtttt 3510361 ccgttcggca cttcttcttt attcgggaga aatttaattc ctttttcaac ggtgctgcgg 3510421 gcatgcatag cgccgatgtc tacgaacgct tctttttcct ctacatcaac gaatacggga 3510481 gaaatgttat caaggctgag tgcccctacg ccaaaaccgc cgtgtccgtc tgtcggatca 3510541 cttttgataa tattaaaccc gattgatttt ttcttttttt cttccatgaa gttctacctc 3510601 ctacaaaagc ggttgaaata tcgctgaaaa cagctttaaa atcgaatctc ttcctgcatt 3510661 gagcatcggc cacagcacgt aagatcctag cggtgtcaca aacagcacca aaaatacgat 3510721 aaagccgtag ctctccgcct gcgtcatttt ggcacgcacg cccggcggaa cgagatcttc 3510781 tataattcga tagccatcga gcggaggaag cggcagcaga ttaaataaaa acaagacaag 3510841 attcagctgt atccaaatag aaaaaaactg atccagcccc gtgctgaacg ccgcaagcat 3510901 ttccattccg tacgcatgca tcaacactaa caaaaagaaa ccaataaacg caagaatcag 3510961 gttactgacg ggcccggcta tagatacgag cacaccagca agccggggtt tcttaaagaa 3511021 acggcgattc acgggaatgg ggcgcgccca cccgaatccg gccaccagaa tcaaaatggt 3511081 tccgaacgga tcaaggtgtt taatgggatt cagcgtcagt cttccttgtt ttttcgccgt 3511141 atcgtcaccg aatttgtatg cgacataagc gtgggcaagc tcgtgcatcg taaacgacac 3511201 aattagcgtg atgacgaggt atggcattaa agataacgga taatataaaa aacggtccaa 3511261 gtgagatatc cctctttctc aaaatgcaag aatttacttt attcagtata ctataagaag 3511321 cctctttttc taaagagagg aaacgagata aaggaggatt cagcacccat gccatacgta 3511381 actgtcaaaa tgctcgaagg ccgtacagac gagcaaaaac gcaatcttgt cgagaaagta 3511441 acagaagccg taaaggaaac aaccggtgct tctgaagaaa aaattgttgt ctttatagaa 3511501 gaaatgagaa aagaccatta tgccgtcgca ggcaaacgcc tgagcgatat ggaataatct 3511561 ctataaagcc ggcgcttcgc gcaccggctt ttattatccc tattgagcca gcttcgcaat 3511621 aatcgccaag aacgtctttt tctcttcggc tgttaaacgt tcaaacatgc catcaatcag 3511681 ctgctggcgg ttttcgatca tttgttcagc cgctccccgg cccgattcag aaagagtaat 3511741 ccatacagtg cggcggtcat tgttatttct ggatctctca ataaaccctt cctgctctaa 3511801 atgattcaga gctgtggtcg tggcagaggg agacagtgtg acctccttca aaatatcctt 3511861 tatggtgcag ctcccatgtc tgtatatgat ccgcagaata aaccctctta cattattcac 3511921 gtgtttcgga acggtggctt catctaattg cttcgtgctt ttcaaatact ttgtaagtgc 3511981 gtgatccagc aaatttgctt ccagtttgtc atggtccatg tcaatttccc catttcgaga 3512041 tgcattcata acatacgaac gatatgattt acttattatt ttactgattc cgaataggga 3512101 aagtcaaaaa agcaaaatgt gaattcacag cttttatcct acatgcctcg attttccacc 3512161 tgtttcacaa gtttatcttt aaaagtttgg aaaggaacgt gttcattctg ctgatgtccg 3512221 aatcggcgga cgtttaccgc attctcctgc tcctcatgat ctccaagcac cagcacgtac 3512281 ggaatttttt gcacctgcga ttctctgatt ttatagccga gcttctcatt gcgctcatca 3512341 atgccggctc ttatccccgc ctgcttcagc tccgcctgca cttttctgca atagtctaag 3512401 tgaacgtgcg aaaccggtat gatttgaacc tggatcggtg cgagccagac tggaaaagcc 3512461 ccaccgtaat gctcgatcaa aatgccgaag aaacggtcga ttgagccgaa aaccgctctg 3512521 tggatgacaa cgggacgaac cttctcattg agttcgttga tatatgttaa atcaaatttt 3512581 tccggcattt gaaaatcaag ctgaattgtc gcgcattggt ggctccgttt cagggcatct 3512641 tttatatgga aatcaatttt cggcccgtaa aacgccccat cgccttcatt gatctcataa 3512701 gagaggccaa gctcctcaag gacgcgtgct aaggcacgtt ccgacgcttc ccaaaggctg 3512761 tcatcgccta atgaatcctc cgggcgagtc gaaagctcaa cagaatactc gaaaccaaat 3512821 gtccgatata cctcatcaat cagccgaatc gcttctttga tctcactctc aatctgatcc 3512881 tcccgaacga aaatatgggc gtcatcctga cagaacgtcc gaacgcgaag cattccgttt 3512941 aaagcgccgc tgtattcatg gcggtgcacc tgtccgaatt ccgccatgcg aatcggcaga 3513001 tcccgataag aatacaggct gtttttaaag atgagcatgt ggccggggca attcatcggc 3513061 ttcattgcga atcttgtatc atccacttct gaaaagtaca tattgtcgcg ataatggtcc 3513121 caatggcctg actgctccca taaccgctga ttcatcataa acggcgtacg cacctcatcg 3513181 tagccggcat ttgtttgcag ctcacgcgag aagcgctcca gctcattgcg gacaatctgc 3513241 cctttcggca aataaaacgg catccccggc gcttcttcag aaaacataaa cagccctaac 3513301 tgtttgccga gcttgcgatg gtctcgtttt gccgcttctt ctagcatatg caggtgcgca 3513361 tccaaatctt ttttcttttg aaacgcaacc ccgtacaccc gctgcaggac ttcatttttg 3513421 ctgtctccgc gccaataagc gcctgatact cttgtcagtt tgaacgcctt gatcatccct 3513481 gtagaaggaa gatgcggccc tcggcacagg tcaacgaatt ccccttgctg gtacagtgtg 3513541 atatcctccc cgcgcggaat atcctttaaa atctcaagct tgagccgctc gtctttttgt 3513601 gcaaacagct cttcagcttc ttcgtaagaa acctctatac gtttgatttc aaggttctca 3513661 tttattatgt ttttcatttc tttttcgatg gcctctaagt ctcctgatgc caagcttttc 3513721 cccagcttca tgtcatagta gaagccgtct aaaatcacag gccctacccc caatgacact 3513781 tcgccgtaca gccgttttac tgcttgggcc agcacgtgcg ctgttgtgtg gcgaagcacc 3513841 tgcaagcctt cttgtgaatc gagtgtgaca atcgaaagct cagcatcctc ctccagcttg 3513901 aaactgagat caacaagctt gccgttgacc tgacctgcgg ccgccttctt ttgcagactg 3513961 gaactgatcg aaccagccgc ttctttgatt gtgatgcctt tcggatattc ctggatctgt 3514021 ccgtccggaa gctgaatgtg tacatgtttg ctcattttag aacactcctt attcattgtt 3514081 gtatataaaa aaacacaccc gtcccgcaga tagggacgag tgtgtgatta acccgtggtt 3514141 ccacccaagt tcccgacaaa tactatgttg tcggctcggt gctgtaacgc agcatagacg 3514201 gcattggtta cttcagttcc ccaatgctgc tccaaggcgg taaatgatat tcctaagctg 3514261 ggaagctctc acctttcctt ccctctctga aaaccgtaac tatcattcat gtccttttca 3514321 tcgcatgtat tcaattcata aaaaaacaca cccgtcccac agatagggac gagtgtgtga 3514381 ttaacccgtg gttccaccca agttcccgac aaatactatg ttgtcggctc ggtgctgtaa 3514441 cgcagcatag acggcattgg ttacttcagt tccccaatgc tgctccaagg cggtaaatga 3514501 tattcctaag ctgggaagct ctcacctttc cttccctctc tgaaaaccgt aactatcatt 3514561 catgtccttt tcttcgcatg tattcaattc aaataaaaaa acacacccat ccctctaaaa 3514621 gggacgaatg tgttgatcat ccgtggttcc acccaaattc ccgatcaatt acacatgatg 3514681 atcggcttaa agatgctgta acgcagcatg acggtatcag atacttgttt tccctgatac 3514741 ggctcaaagg cggtaagctg ctttccctgc gttaggaaga tctcagctgt ccttccctct 3514801 ctggaaaccg taaaaagcat ctcgtgtcct tatcagtgcc tgttgtttca ataatttttt 3514861 atatcttact atatattccc acaaagcgca atcagtgatt tacatttttt ctgacgcggc 3514921 agtcccgtta tgggcagcca gaaacagcca tacaagcaat gcagcgaggc tgtatgccgc 3514981 tcccatcatc aaaaacgcaa acccggcacc agcataccaa gtggcggaca gatgaatgat 3515041 caccccggtt atcgctacgc cgaccaaggc tccgatttgc cggtttgcat ttaacgccgc 3515101 accggcgata ttcgtatgtc tttgcccggc agcctgcatg atcacagttg tcatggcagg 3515161 aactgtaata ccggtacaga ggttcataac agacatcaac accgccagct gccaataagg 3515221 aaaatccgga gaaatcagca caaacaacag caatgcaatg atacagctga ccgccattga 3515281 tacaaacata agctgaccgg cttcaaaccg attcgccaga cgggcaaaca gcagattgcc 3515341 gatcacgaag accgccatca tcggcagcag ctccactcca gccataaagg aacttgcccc 3515401 tcctgcttcc tgcaaaaaaa ggctgagcat aaacatgccg ccaaaaaggg cgaaattcag 3515461 caaaaacccg ataaattggg cagctgagaa gcggccgttt ttgtataagg acgccggcag 3515521 gatgggtgtt tttgcagaaa tttcccgcag caaaaacagc acaaatgcca aaaccgctgc 3515581 agtaaatgct acaagaatca ctggcgagcg ccagcccgct gaaggcccct gtatcaaagc 3515641 ataggaaaga aacccgagag ccatcatgcc aagcagatgc ccgatgatgt tcacgcggct 3515701 gcttttccca ggaacgcggc tgaggattcg gtaagctgaa atgagcgcag cagcccctat 3515761 tggcacattg atcagaaaaa tactctgcca gcccgccaac tgtaccagca cgcccccgat 3515821 aaaaggccca agggctgaag cggcggaaac aagcgcggcc cacagtccaa acattctcgc 3515881 ccgcgcccgc tcatcaaggt aagaggcagc caaaaggctg agtgagcttg gcataaacaa 3515941 agctgcccca attccctgta tgagacgtcc ggcaatcagc atctgcccat ttatagatgc 3516001 agcgcataga caggaggcca taacaaaaac ggctagaccc aagatataga tcgtcttcga 3516061 gccgaaacgg tcagccaagg ctccgcccgc cagcagaagc gacgcaaaag taagaatgta 3516121 cccgtccaca acccacgtta cacctgaaag tgacattgaa agagtgtttt tcatatcagc 3516181 catcgccaca ttcacaacgg tcacatcaag agttgccatg aggaaaccaa gtgcgagcac 3516241 gatcagcacg gatatgcctg ttgatgatgt tgattcttgt atagacccgc tatttttcat 3516301 tacaattgcc ctttcacttg cttgattacc caatcatcta ttttttcaag atcatacaat 3516361 tccccgactc tgtccataac atgctgcaag gattcttctc tcataagatt ggaccattta 3516421 tcctcgattt ccgccatgac tgtctccagc acacagtgac tttcaccctc aaatacagat 3516481 tgcagcaagc ctttcccctg atacatcgaa cctctgcctt cgaccgcttg ataaacatca 3516541 taaagcgtaa tgtcagccaa aggcttcgtc agggtaaaac cgcccttcgt ccctggtaag 3516601 gattctgcca aaccggcttg aaccaatgtt ctcatcagct tcttcaagta agacggagac 3516661 acgcgcaatc gctggcttat agcctctgac gtcaaagaag cctgtaccgg cagccgtgac 3516721 agtaacagca gcacagaaac cgcctgctcc attcctgatt tcattttcat cctattcact 3516781 cctgattcat tatggataac tattatccat aatgaatctc ttagcagctt ttgtcaataa 3516841 aaaaagcaaa agaaacggat catttctttt gcttggtatg gttaacaaat ctgcttcagt 3516901 tcctctatgt attgaagcgc ttcgtcatat tcttcatttg tatatttttg cttgcttttg 3516961 atggtaaaga ctttttcttt cttttcctca tcctcaagcc cgtcaaagta aaggatcgtg 3517021 gaaaccagct ctaaaaaccg tgatgaacgg ctgtttacac tgtcgatata gcctttcata 3517081 tccggcatgt ccagatcagc atggtctaaa aatgcggagc ctgtctcagt cagcgaatac 3517141 cggtattgaa agtagccgcc ctttttttcc ttcacctcat gcagaaatcc aaggttgcac 3517201 agctcttcaa tctggagcgt cagttcctct gaatatggtc cgtaaaagtg aaaatcatat 3517261 ttctcataga aaggaaactg cattttcttg gcgatataaa tcattttctg cagcttcttt 3517321 cgcccgatga tttctccaga atccgagaac accttcatca gttttgcatg ttctttcaac 3517381 aaattcccga catctccttt ttccttcttt ccaatttcta tgtcagtccc agcagctgcc 3517441 ggattttcat tttcgcttcc ggatgtttag tgccgtcaca aatcaagtcc tttggatagt 3517501 acagcttgtg gtccgtccgc cgtttacctg agatggattc cacaatagcc gactgtctgg 3517561 acagctcttt aatttggccg ttttgcgtca agagatggat cggcagacgc tcctcttcct 3517621 ctcctggtcg gtaaaaatcg tatggcagat ctgatgaaga atcaacgacc aaataatagc 3517681 tcggatcgat ccccgcctct ttgaacaatg aagtcagctc aaaataagcc gacatttctt 3517741 cattcggatt gaattcaacg tattggaaaa gctggcggtt aatgaatctg cggcacaagt 3517801 cggataaaat cgcgtcttct tcatcctccc aggcctggaa gtaatacaaa ataatagatt 3517861 catccagctt tacataatcc tccagtgtca attttccttc aaaaatagaa tagaaatgaa 3517921 ccggagcgtg agtgaagaca tagccttcat cgtgcagctg cttcgccctg tgaagaatct 3517981 tcgttaaaat gacctctgca cttctagtca caggatggaa gtagacctgc cagtacattt 3518041 ggtaacggct catgatatag tcttcgacag cgtgcattcc gctttcttta atgacgatct 3518101 gatcctcgcg cggccgcatc acccgaagaa tccgctccat atcaaaatgg ccgtagctga 3518161 cgcccgtata atatgcgtcg cgctggaggt aatccatgcg gtctgcgtca atctgactcg 3518221 aaatcaggct gaccacttgc ttgtttttat atgttttggc aatgacttca gcaacatcct 3518281 gagggaaacc cgggctcacc tttctgagca cctgattaac ctccgtgtct cccaaaatga 3518341 tacctcttgt aaaatcctcg tggtcaaggt gaaagacctt ttcaaatgaa tgcgagaacg 3518401 gcccgtgccc gaggtcatga agcagcgccg cggccaaaca gagttcgcgc tcactgtcat 3518461 cccattcagg gcggccttta aagacgtcat caaccattct tctgacaatt tcatagacac 3518521 cgagagaatg gttgaaccgg ctgtgctcag ccccatggaa cgtcaaatag gtcgttccga 3518581 gctgcttaat tctgcggaga cgctgaaatt cacgggttcc gatcaaatcc catatcagct 3518641 tgtcccgaac atgaacatag cggtgcaccg gatctttaaa cactttttct tctgataatt 3518701 ttccatttgg atacgccatc gtcattccct ctttttttta gccgtgtttc tattatatcg 3518761 actctattct ttgaaaacat ccttgaattt gcccggcgat ttgttccatc ttcatgaaaa 3518821 acacatcttg tgaagcaaaa aagcctgacc tgagggccga ggctaagaaa aaatatgttt 3518881 ttactttttt attttctttt ttactttgtc aatcagctca tcctctgtcg gagctgacag 3518941 cgggcgattg ttcacaaaag caaatgattt tttccgtccg ggcccgcaat aagattggca 3519001 tcctacctca acctttgcgt ccgggtccac ttctttcaaa cgcggcagca atgttttgat 3519061 attagtggct tggcaatcat cacacactcg aaattcatta gccatgacgt acgcttccct 3519121 tcatttctat gttcatctat gtgaataacc taaaatcacg tttcaaaaaa aatcacatca 3519181 cacttcattt tacaaggatt cgactgttcc tgcaagccgc tccatccttc gtatctccta 3519241 ttctttcagc caatttgtat aaatattttc caacctggac attctaatac catgaaaaga 3519301 aaaatgggag ttgagataaa tgacaaaaca gcgacaagac gcttggtcag aggaaaacga 3519361 tctgctttta gccgaaacag tgcttcggca tgtgagggag ggcagcactc agctgaacgc 3519421 ctttgaagaa gtcggcgata aattaaaccg gacatccgca gcctgcggat tcagatggaa 3519481 cgcagtggtc cgccatcaat atgaaaaagc gcttcagctt gcgaagaaac aacgaaaaca 3519541 gcggatgaga gcgctcggaa acgggcagcc cgcgaaaaaa agattattat atcagcctcc 3519601 tgccgttgat cctgaaatca ttcaagaaac cgctgcagaa gagccggtta aaacggaaac 3519661 accatctgtc gaaaatgagc aacctttaat gtctggcgaa cacatgcctt ttgttgatga 3519721 aagctttaag gaagagttag ctagtctatc acacttattg tctcctcaaa cgcctgcagc 3519781 tgcgcctgag atgacgatga atgatgtgat ccgcttcctg cagaattacg aaggcaatca 3519841 cgagcaatca tcagcattaa aaatggaaaa cgagcgttta aagaaagaaa atcaggaatt 3519901 gcaaaacaaa acagagcagc tagaggcaga agttcaaaag cttgaaaaag accaaaaaac 3519961 gatccaagaa gattatgaaa ccttggtgaa aattatgaac agagccagaa agctagtttt 3520021 atttgaagaa gatgaacatg cctctccgtc cttcaaaatg gaccggaacg gcaatttaga 3520081 aaaattagcg gaatgacata gaaaaatccc aaaacgggca gctgttttgg gattttcgcc 3520141 atgtgcaaaa tccccttttc tattgagaaa agagaatttc ctcattttgc agccggatca 3520201 gctattcttg taaaatgagg ccaagcttat gtgaatctat taagacatgt gagctgcctc 3520261 ggccgttttt tgtttccgag gcgcagcaga aatgaccaaa agccccagca tcataagcgc 3520321 aatgcccagc cacgaggaag gcgaaagcat ttcccctatg aaaaacacgc caagcaatga 3520381 agccgtcagc ggttcagcta aagacagcgt gaccgccgcc gaggccggaa ccccggtaag 3520441 ccctttcgca aacaaaaagt atgcggcaca tgttgcaatt aacccgatgt aaaggcttgt 3520501 tcccagtcct ctaggggtca atatccacga gatatctaac tgccataata gcggcgtcag 3520561 caagatggcg ctgatcatga atacaacggc ggaggtcgct cgcggaggct gggttttcat 3520621 catcgcttta ctgatgagcg tatagcctgc aaaagaagca cccgctccaa gcgccataag 3520681 aacaccagcc acatcaatcc gaacattgga actgtcggaa aacagaagcc agcaacccgc 3520741 taaagccagc acagtcgcaa tccaccagga gtttcgcggg cgtttcttca atacagccca 3520801 ttcgagggtc ccggcaatga taggcgcact gccgatggca atcacagttc ccactgcaat 3520861 tcccgtttct ttaaccgctg tgaaaaacag cggctggtaa cacgccatac aaacagcggc 3520921 taaaaatacg agcggccatg cccaattttt cacgtgaagc tcccggctga tccaaaccgc 3520981 aagcagcatg gcgcttcctc ctattaataa cctgaacgct ccaaatgcca gcggtgtggc 3521041 gctttctgga gccaatgcct gaacggttcc cgtggtcccc cagaaaaaag ccgcaatcaa 3521101 tacaaaaagg ctgtaaatat tccccttcat ctgcctctcc cctttaatat ggatgctgat 3521161 gtcattttat cgtttttctt tttgtcgtgg ttatctgtat gtaagaagga cttatctgaa 3521221 aataagatta ttgaggtaaa atgccgcttg agataaaaaa tgcatgccgg catatacagc 3521281 cggcatgcga agaacgttca cccaaatacc tttgcattcc gctcagccat ccggacgagg 3521341 tttttctcaa attccatttc ctcatcaatg gacagtccag ctgaataaag atgggtgctt 3521401 aacgctttta attccgtcaa taaagcgaac attaagtctt gtacggagat gtctttttga 3521461 agaagctcac ttaaggacgc catcgtttcc ggacgtattt ccggatagac gcctttttta 3521521 tcgttttgtt tgtctttcag cgccgcttga tagaatcgtc tgatcaagtc ggccctttca 3521581 ctgccgcttt tatctgcaca gagataaatt tgaacagcga ctccgccgcg aacgcgtctc 3521641 tgagagatgc cggcgaactt tttgccattt atactgaggt catagctgcc gggacaataa 3521701 gacccttcaa tttcataggc ttcgatcttt gcgttgtacg gtctcagcat tcgtctcatc 3521761 agctcgacca tcgcttcata tcctttgtct atatcgatgc ctttcttttc gtcctcgaat 3521821 atgagagaga tatttaaaac accgtcatcc aatacgacgg caagaccgcc ggaattgcgt 3521881 acgatcacac ggtatccttc gctctccagc aaggagatac catcctgcaa aaacgggagg 3521941 cgtgtatcct gtattccaag gacaattgta tcgtggtgca cccatgagcg cgctgtcgcc 3522001 ggcgacacgc cttttccgac ggacatgcat agcgtatcat ccattgcgaa ggattgcttc 3522061 gcatcaaata aagggccgag actggattgg tcaatgactc tccatttcgg ctgcatcagt 3522121 aaatcaatcg gttggtttgc catctatgta aaaccctttc atgttaggct tattgaacga 3522181 aaactattat atcatttcag cagctgtgat tgataattgc ttttcagcat cgtaataaaa 3522241 atttctttat tttttgtatt ctccatgaga ggagaatgaa tgtaagacag cttgcgcttt 3522301 aacgagaaat tattaatatg cagaattgaa atttcgcggt ggatcaaatc cttacgcagc 3522361 acgcttctgg atagaaccga aagtcccatg ccgttaatca ccgcttcctt tacaccttga 3522421 ttgctgctga tggtaaacat tgatttcggc cgaagtccat ttgaactgag tacatgatcg 3522481 agatattctc tcgtcccgga gcctttctct cttgtcaccc acgcttcgtt ctgcaaatcg 3522541 ctgatcgaaa tctctttccg cccggcgagc ggatgctgat ttggagcggc aatgcacatt 3522601 tcatcctcca tgaacggttc aatttccagc tcattctcgt ttgtatgtcc ttcaatcagc 3522661 ccgatatcag cctgaagcat ccgcacacgc tcgctgacct cctctgtatt gccaatcatg 3522721 acatctagat tcagctctgg atacagcttt tgcagctggg ccaatagcgg cggaagaata 3522781 tactcaccga ttgtaaagct tgcagctatt ttcaattcac ccttcacata gtgatgatgc 3522841 gcatagattt cagccttggc ttgttcgtag agaaacacca tttgctttgc tctttgatat 3522901 aaaatgtctc ctgtcggcgt tgtcgtaaag tgttttggcg acctgttcag aagagccgtt 3522961 tgaaattctt tctcaagatt tttgatatgc agactgacgc tgggctggga gatcatcagc 3523021 ttttccgccg cttttgtgaa gtttttttct tctaccaccg ctataaacgt tttcagcacg 3523081 tcgtaataca aaaaccccac ccctgtcatt aatgaaatat atggttatga ttagttttct 3523141 ttattgtact catatcatcc gtcttggtaa agaagggcta tacagaagcg caaaaaaggc 3523201 agccctcggt cgagagctgc cattgtcttc aattttatta cagtgcttgc gccgctgtaa 3523261 ttaatgcgag attgtaaaca tcttcagcgt tacatcctct tgaaaggtcg tttacaggca 3523321 tatttaaacc ttgcaggatt ggtcctaccg cttcaaagtt gcccaaacgc tgagcgattt 3523381 tatagccgat gtttcctgct tcaagacttg ggaatacgaa tacgttagcg tcccctttga 3523441 tctcggaatc cggcgctttt ttctcagcta cagatggaac aaatgcagca tcaaattgga 3523501 attcgccgtc aagtgtcagt tcaggcgctt tttctttcgc gattttcact gcatccgcta 3523561 ctttttctgt ttcatcagat tttgctgagc cttttgtaga gaagctgagc attgccacgc 3523621 gaggctcaat gtcgaacatt tttgccgtat tggcactttc gatcgcaatc tcggcaagat 3523681 cttggctgtc aggtgcaatg ttgatcgcgc aatctgcgaa tacgtattgc tcttctccgc 3523741 gagccatgat gaacacgcct gaagtctttt tcacgccttc ttttgttttg atgatttgaa 3523801 gagccgggcg gacagtgtca gcagttgagt gagcagctcc gcttacaagt ccgtctgcaa 3523861 gtcctttata caccagcatt gtaccgaagt agttctcgtc taataatgct ttacgagcct 3523921 gttcttcagt cgctttgcct ttgcggcgtt ctacgaatgc ttgtacaagg tcttccatgc 3523981 cttcatatgt atgaggatca taaatcttaa cgccgcccag cgtaaggttc aattcttttg 3524041 cttttgcttg gatctcattt tcattgccga tcacaatcgg attcagcact ttgtttcctg 3524101 caagcttgct gaccgcttct aaaatacgct cgtctaagcc ttcaggaaat acaattttaa 3524161 cgtcttttcc agctactttt tcttgcactg ttgaaaataa atctgccaca ataaaacctc 3524221 ctcaaaaagt tacaaaaacg ctttctttta ctagcatact cttcttccaa tcaaattcaa 3524281 acagccaact ttcattatag cgctttcata aaaaaatctt atttttctaa ctaatttaag 3524341 tgactcaatc ttcccttata ggttcttcta ttttgatgga gttatacgga agggatgttc 3524401 aaggtttctc cacagtagaa tcggataaac tatggtatag tgaaggcaat catgaaaaga 3524461 taatgggagt gaagataaat gagtgaacag caaatgacga atgaagcggc aaaaacgctt 3524521 gacggctggt atgcgcttca tgatttccgc acaatggatt gggcttcctg gaagcttctg 3524581 tccagtgatg agcgccaatc tatcatacat gaattcaccg ggttgcttga aaaatggggc 3524641 gtagcccaaa aagaaggaaa aggatcgcaa actctttaca gcatcgtcgg ccaaaaagct 3524701 gattttatgc tgatgatcct tcgtcctaca atggaagaat taaatcaaat tgagcttgaa 3524761 ttcaacaaat caagacttgc tgagttcacc attccggcat actcctacgt atcagtggta 3524821 gagctgagca actacttggc aagcggtgac ggcgatcctt atgaaaatcc gcatgtgcgc 3524881 gctcgccttt accctgaact gccggaatct aaatatgtat gcttctatcc aatggataaa 3524941 agaagatctg gcaacgacaa ctggtatatg ctttcaatgg aagaacgcag aaacttgatg 3525001 agaagccacg gtttaatcgg ccgcagctat gcgggcaaag tcaaacagat catcaccggc 3525061 tctgtcggct ttgacgatta cgagtggggc gttacattat ttagcgatga tgtccttcaa 3525121 ttcaagaagc tagtgtacga aatgcgtttt gacgaagtca gcgctcgcta tggcgaattt 3525181 ggttcattct ttgtcggcaa tcacctttcg cttgatacac ttcctcaatt cttatatgta 3525241 taatatcccc tcccgcccta tccggcggga gtttttcaat tctcctttat cagaatttaa 3525301 ataaaatttg ctattttctt cgttttttct tacgatgtag ataataatcc atttttttca 3525361 aaggggtgca gttatttgtc aaaacgaacc gcatttgtta tgggagccag tcaagggatc 3525421 gggaaagcaa tcgctctgaa attagcagac cagcactttt ccctcgtcat taattcgcga 3525481 aatttggata atattgaatc tgtcaaagaa gacattttgg ccaagcatcc tgaggcgagc 3525541 gtcattgtcc ttgcgggcga tatgtctgac cagcatacga gagcgggcat ttttcagaaa 3525601 atcgaatctc aatgcggacg gcttgatgtt ctgattaata atatcccggg cggcgcgcct 3525661 gacacatttg ataactgcaa tatagaggat atgacggcca cgttcactca aaagaccgtt 3525721 gcctatattg acgcaatcaa gcgtgcttcc tcactgatga aacaaaacga gtttggcaga 3525781 atcatcaaca ttgtcggaaa tctgtggaaa gaacccggcg ccaacatgtt cacaaacagt 3525841 atgatgaatg ccgctttaat taacgccagt aaaaatattt ccatccagct tgctcctcac 3525901 aacattactg tcaactgtct gaatcctggt tttatcgcta cagaccgtta tcatcaattt 3525961 gtggaaaatg tgatgaaaaa gaacagcata tccaaacaga aagcagaaga acagattgct 3526021 tccgggattc cgatgaaacg ggtcggatca gccgaagaaa ccgcagcgct cgccgcattt 3526081 cttgcctctg aggaagcctc ctacatcacg ggacagcaaa tttccgctga cggcggcagc 3526141 atgaaaagca tataaaaaca tcccgctttt tagcgggatg tttcttgtaa tgacccgaac 3526201 ggcaggttca gcttttgaat ccgcgtgaca aattcccgca gatcctcctg cttcgacacc 3526261 attgagattc tgacatgcct ttttccgttg cttccaaaaa tttcgcccgg tgtgactacg 3526321 acatgggcat gctccagcaa gtaatcggaa aattggtgag atgtctcaaa cgtattcgga 3526381 atttcagccc atacgtaaaa ggttcctttt ggcttttcca tcttccagcc cagttccttt 3526441 tcacaaagcg ccgtaaaaaa gtcaattcgt tccttataaa ttcgtttcaa cgattccgta 3526501 tgctccggat ctccagaaag cgccgcactc gctgcctgct gcagcccgcc gaacatgccg 3526561 acaaatacat gatcctgaaa ttcattgacg gcctgaatga ttttttcgtt cccaaccgca 3526621 aacgccattc tccagccggc catgttaaat gtttttgaaa atgaataaag ctctgctccg 3526681 acagttttgg catcctctgc ctcaagaaag ctggccggtt tttgatcgaa ttcaaacgcc 3526741 ccgtatgcaa aatcatgaat caaatggatg ttatgctctt tcgcaaaagc agcagctttt 3526801 gcataaaaag ccgcatcagc cacagctcca gtggggttgt tcggatagtt taaaaacata 3526861 agcttcgctt tttccagcac ggctggatca atcttttcaa aatccggcag atagccattt 3526921 tcttcataca gcggcatttc gtaaagctca gctcgcgcca tcgtaatccc tgataaatat 3526981 tcaggatagc ctggattcgg gactaaagcg atgtctcccg gattgagcag gcattgtgtc 3527041 agcacataca atccggcttt cccgcctccg aaaagcgcga cttccgtttc aggattgatt 3527101 gtcactccgt attccctttt atagaaagcg gcgatcgctt cctttaaaaa aggatagccc 3527161 ctgaaagggc cgtatccatg aaacgaagga ttcagagaag cctcccgcaa agcctcgaca 3527221 atatgcggcg gagtgggaag gtcagggttc ccctgtccga gattaatgat atgggctccc 3527281 gttttttcca tttcctttac cttttgaaaa acgagagaaa actcctgcct tggaagtgtc 3527341 ttgatgacat cggacggtgt tatttccatc taaaagactc ctttttgctc cgttttgtta 3527401 tcccgttcca aaaacgattt gttgacgagc ttcgtatgca aaaacaaacc gcatacgatc 3527461 acgacaatca gccccataat gaccggagcg cttaggatgt taatgaacat tgaaccaata 3527521 gaaatgcata atccgataga cgcttcggcc actgaaaaaa tgcgcccttg aatctggttt 3527581 gccgcatttt cctgaacctt cacttttgca agcacttccc cgtattccat cgcgatgaaa 3527641 aagaggatcg ccgcgatgac agaaacagcg aatatcggtg tgaataaaaa cagcgccagc 3527701 gagacaatgg ataaaacggt aaagtacgtc aggcctctat tgttgttaaa gccccatttg 3527761 ctgacaagcg ccgctccgat aaagccgccg aagccgatgc agaacgtgag aataaagttg 3527821 ccgatttccc cgtcacccag aaagcggctg acaatcggaa aatagctgta cacaactccc 3527881 cacagcaaag ccattgtaat catcgtaaac atggcgttta atacgaatga attggttttg 3527941 atttccttga gtccttcctt aaaagactga aaggcctctt taatgttttc agattgaatc 3528001 ggcacaaatt gcagcttgat gcggctgata aaaaatgccg aaaccaagta tgtcacaccg 3528061 ttaaaggcaa cagccagctc tacagatccg cctaacagaa agagccctcc ggcagccgcc 3528121 ccgacgataa tggagatggt tgtcgctttt gcaaataacg tgttgatgct tttaatatct 3528181 gattccaagg acgacatgac agcgagacgg gcgggattaa aaaacacgcc gcttccataa 3528241 gtaataaaca gcagggccag aaaaatcagc ggatactcgc cttttggaag aaatgtgagc 3528301 cccaaaaaga tgatgcctct gatgatatcc gtccacagca tgatcttaat tctgtctaac 3528361 cggtcgacca gaacacccaa aaacggctga aacaccatcg gaatgcttct gaccacgatg 3528421 accccggacg tcacccaata atcgtgataa tatgtagaca aaatgagcag ggcagggaga 3528481 acacaatagt ctcccatgaa cgatagcgcc tgcccgtaaa gcaagtattt agagttgggt 3528541 ttcagctgtt tcatactggc agcacatact ttgccgtcag cttcgcatgc tgctgaattt 3528601 gtctgattga ttcagccaca tcctgtgaat tactgccttt cagttcaaat gcagcaatgg 3528661 aattgaaagc ttcaaacaat gtcaaatcaa ctgaagtgcc tggtgctgcg gccgaaaaag 3528721 aaacgatttc agtatcccct tttaaaagcc cgtccggaat atcgatcgct tcaatgacca 3528781 aatcctcagc agtttcagga atttggccat tttgtttgaa atgctgcggg tacaaatggc 3528841 agtcggcaac ataataaggc tcttgatcca ataatccgtc cggcagatcg gcgtcttttc 3528901 cgaaacagag gacatctaat aataattgcg ccatatcaag gccaaagacc tttttaatat 3528961 tggggatcat attccagccg gcaaatctgg ctgccgactc tattaaaccc ggttctctgt 3529021 ttttcattag cttgatctct gtatgtgttg cgcaattttg cagtccaagc ccttcatttg 3529081 cctttttggc agcttcgaca attttctttt ttgcctcttc atccagaatg gacggcgtaa 3529141 tgtgggatgt ctctgtaaac ccgatttgcg gcgttttatc atgaatggcg atcgggaaat 3529201 actcaccgtc agccatgatg ccttctatac tgatatagtc ggagtaccct tctgtttgat 3529261 accagtctcc gtactcaccc tgtaaaaatt cttcagcgat aaacggcgct tcaaacgtaa 3529321 ccgcctttgg cacgttaatt gatttcagat agtcattgac tctgttaaat tcatcttctg 3529381 ccgtctcagt gtccgtaatc agcgttacac cgatagaact cgctaagtat gtaggcttta 3529441 agataagagg tgtgccgatc tcttcaagag cagcacggaa atcttcaaga gttgtgactc 3529501 gtttgttttt gatcgatttg actccggcct tattaaaagc gtccctcatt ttatttttat 3529561 ctctggcatt ttcggctgcc tgcacgccgg cacctctcaa gcccagacgt tcacaggctt 3529621 tcgccatcgg agcaatgaat aattcattgt ttgttgtgat ggcatccgcc ccaaacattt 3529681 cggcaacctt gacgatttgc tcgacgacct cttcctcagg cttgttatga tcttcatgcg 3529741 cccaataaat ggaatcaggg tgttcaaaat cagctaaact cttaaaatag tctttatctt 3529801 ttatgaccgc gaccgagtat ttttcaatca atgctgcatg ggaggctgta attgcaaaag 3529861 gtcttggaat aaagctgacc aggttatatt tttcagcagc gcttttataa aacatgtgcg 3529921 gcgggcagcc tccaagatca gcgatgacca atactgtttt tctctccata tgtaaaacac 3529981 tccttctcta ttgtgcggtg tatcctccgt ctgcggtgat ggcgcttccg gtcatatagc 3530041 ttgataaatc cgaggctaaa aacagcatca catttgcgat ttcttcaggt ttcccaagcc 3530101 tcagcagcgg atttaccttc gctttttctt ttttaatctc ttcaagtgtg ccttcattat 3530161 tttcaaggaa tgatttttca ttcagcggtg tgtcgatgat ccccgggcat acgcagttca 3530221 cccgaatttg atgtttcgca taatcaacgg ccattgattt agtcagctgc aaaaccccgc 3530281 ctttgctggc gttataagca ggaatatcag gccatgccac gagtccgccg acagagcacg 3530341 tattaatgat gttgcccttg ccggcggcca gcatatgctt gagtgcatgt ttgctcatta 3530401 aaaacatgcc ggtcaaattg acttgcagca ccttgttcca atcgctgagc tccatctcgt 3530461 gaataggcgc cacgatttcg atgcctgcat tattaatcaa gacatcgagc ccgccaaatg 3530521 tatgaaccgc cgattcaact gcgtgctggc aggcagcttc gtctgtgatg tccgtttgca 3530581 caaagtgcag cctgtcatta ttttcttttc gtaccattgc ttctccttgc gcttcatcaa 3530641 tatccgccac aaccacattg gcctgctggc ccaaaaaagc ctgaaccgca gcataaccaa 3530701 tgcctgatgc gcctcctgtg atgaggacgg ttttatcggt gaggttcatg atcattcatc 3530761 cgccttcatt ttttttgctt ttgccctgtt atagcgcggc gggaagaaga tattaatcga 3530821 ttttgattct ttttctgaac ggttgatggc accatgatct tcgcgaggct cacagaaata 3530881 ggctgtgccg aatttcatct cgactgtgca gccttcgacc gtcatgtcat agccgccgcc 3530941 gatgcagatg cctatttgtt cattccgatg tttatggaaa ggcatttctc cgccatttcc 3531001 agggattttg gcaagcataa tttctaccca atcctcaaca aagaacgtga cttccatgcc 3531061 cggcagcagg tctcttgttt tgaaaatatc caaaaagtag tcctcaggac ttgtatatgt 3531121 ttcatcagct ttcagccgct tgatatcaat agcaatcact tcttggtctg tgtcgtttct 3531181 tgccccgtga ggcacatgcg gcggcgcgat ataggcagat tccaaggctg tcatttttct 3531241 tgtcacatct ccgacagtca tcatcagctc gccagaaacg accatgccga tttggacctc 3531301 cttatgctga tggggttcaa cattggtatg cggcgggacg taagacatta atacttcagt 3531361 atcccctcgt acggttgaat actgcctcac tccgttttcc cattcaatta atttcggtgt 3531421 cgggaaataa agctcctgca tatcttcttt agttttcatc atcaacgtct ccttttccaa 3531481 ataatgacca gctcattgga atgcttttga atgtttttac aaaggttagc ccgtactttt 3531541 gccgtgcaag ctcattggtt aaggcaatgt catacaaacc ttcttttact tttcttgcgg 3531601 cttgactggt tgaattgact agtttgaaac gaacatcttt gcgggtaaaa tattttatta 3531661 aattaatagg tgaaggatgt gaaacaataa cagatgtatc aagcatatcg tctctgaatt 3531721 caaaatcagg acgaacagcc aggccgtaca tcggtgtatc gcacctgaag atctgcaata 3531781 gctgcaaatc cggcctcatg tagaaatgct taatgccatc gtaagcatgt gggacgatgg 3531841 tatattccag cgggctttgg agcgtccttt cgatgcacga ttcaaaagta tcatgcaagg 3531901 acaatttact gttcagccct tgtagaagag taaaattgga aatgaaatgc tttgctgcgt 3531961 actcactgct tgtcccctca gggccgagcg tgttgactgt aatgagtttg gatagtgaat 3532021 cagttctttt ttttgtctga atgctattat ccaatataat catgagcacc aaccaatctt 3532081 ttaaaatttt aagtaaattt tatccagtgg aaattgaact gtcaatgttt tttgaaaata 3532141 ttgataatta ttcccataca aacaaaaaaa ccctttaaaa agggttttta attataggaa 3532201 tttagaaact ttgtttattg agataaggac tgatcggcct tctgctcaag tttgccgtac 3532261 tttttatatg cgaatacact gagcacaaat ccgaggactg tgatggcggc gcaaatcaat 3532321 ccgacagctg catagccgta tgccacatat acgggtccca ttaaagcaga acctaatgtc 3532381 acggccagat tcgaggcgag actgtaaaac accatgactt ttcctcgatg acgctctgag 3532441 cagtcactca aaatggtgct gagcagcgtc accgtcaaac tttgcattaa tccccaaata 3532501 aataggctgg cgattaacag aaacatagac gccggcgcat atggtaaaca cgccagcaga 3532561 acgctgatga cccccagcgc aatcaaaagg gagcgcattt ttccgatgcg gtcggctatc 3532621 tttcctgtaa tcacactcat ggaaaacccg attccataaa tcatgataaa taagcccgca 3532681 gccgtgtttc ctccggtaaa aacgtcctga agataggtgc ctaaaaagga atacataccg 3532741 taaaaaccaa tcatattaca aaaggttatt gtgatataaa caggtacacg agggactttc 3532801 agcgcatccc ggaatgttcc tgcgggctct tctatttctt ccttgccgct gtttttatgt 3532861 tgggcatggc ggcgcatttc aaggagaatc agcagaacaa ctaaaacacc catcagggcg 3532921 aaaatccaaa acgtccatct ccaatgcagg acgccgccga taaatgatcc gagcggcact 3532981 ccgaaaatca gcgccagcga ccagcttgaa acgatcagtc ccatcacctt gccccggtat 3533041 gtataaggaa cacgatcacc gacaactgcg taagcggtcg gaacaaacgc tcccgcagcc 3533101 aatcccgaaa gcgcccggcc taaaaagaag aaaaaaatat tttgagctaa agcgcatatc 3533161 accgttccta tgataaaaat cataagcccg gccaataagc tcagttctct ggagtattta 3533221 tcgcctaatg gaaccaaaag cggcgcaccg ataaaaatca taacgccgta aatactgata 3533281 gataacgcaa ggacgctgac atctgagctg aaggcttttg ctaaatccgg cagcagcggt 3533341 gagatcacaa gctcttcaga tccggctgca aataccccca tcgttaaagc cagtgccaac 3533401 aataacggaa aatgatgttt tgttttgatg tcattgtttt gattgctgtt cattctttct 3533461 caaacacctc ttccataatc ttcttatcat aaagttgtat tatagtttag cattgttttt 3533521 tctctattta caattcgaac gaaatattta taagttttat tattttcatt taaatcccat 3533581 tatatatttc tatatttcat tctaaaaata catgaggatg taacacgtaa aaaaagctct 3533641 ccggcctccc ggagagcttt ttctattgcg cctctgtctg ctttttttca atcgtttcat 3533701 gatttatacg ctttttgatg cttagatgat agtatgcata acagaaaata atgatcggca 3533761 caccgcagta taagccaatt ctttgatccg gaatgaaaat aaggctgatc aacacgcagc 3533821 catataaaca aaatccgaga atcgggacta gcggataaag cggcgttctg aactccagat 3533881 cattcacatt tccgccttct gccaggaaac gcctgcgaaa gaaaaattgc gacgcacaaa 3533941 tggacatcca cgcgacaact gtcaccatgc ccgagattga gatacaccat aaatacactg 3534001 tttctgcagc catgacactt gtcagcagcg aacagcctga aatgcctagc gtaatcagca 3534061 gggcattcat cggcacgcct ttttttgtca gtctggtgag aaaggaggga cccatttgat 3534121 ttgatgaaag tgaccacatc atacgcgacg ccgcatacaa tcccgaatta gcaacagata 3534181 aaatggccgt taagatgaca aagttcatga tatctgccga aaatgggatg ccgatttgat 3534241 cgagtactgc tacaaacggg ctttcaatca cccccgccgt tttgtacgga aggatggcaa 3534301 ccaagacgaa catagcgagc acaaagaaaa acagcgtgcg ccaaataaca tttcgaatgg 3534361 actttggcag tgttttttcc gggctttcac tttcccctgc cgcaatgccg acaagctccg 3534421 ttccctggaa cgagaagttt accatgacca gcgtaaacat aacggccagc accccattag 3534481 ggaaaagccc tctatcagtc ataaagttag acaaaaaggg tgtctcctgt ccgcctttaa 3534541 agtcaatcaa gccaaacaca gcggctccgc caatcacaat aaataatatg atcgccgcca 3534601 ctttgatgct tgaaaaccaa aattccattt ccgcaaagct tctgacagag agcgcattaa 3534661 tcaaaaagat gacgatgccg aacacgaggc accatatcca gatcggaacg gagggcagcc 3534721 acctttgcat caaaatgcct gctgacgtca gctctaaccc tactgtattg gcccagctga 3534781 accaatacag ccagccaatc ataaagcctg tcgactgtcc cagaaattta gtggcgtagg 3534841 cctgaaacga tccggccacc ggcatggcaa cagccaattc tcctaaacaa agcatgacga 3534901 gatacattaa aaatccgccg atgatatacg cggcaatggc gccgagcggt cccgcctggc 3534961 taatggtaaa gccagagcct agaaacagcc cagtgccaat cacccctccc aaagcaatca 3535021 taaacaaatg cctgcttttc atgctgcgct gcaattcatt tttatgattc tgcatcatcc 3535081 ttcccccttt ggttcttttg ccgtgatggt catccggtag ctttgcaaaa gatgaacggt 3535141 ggtttgctgt atgaggagag gcaatacatg aaatgtgtac ggtttataga ctcgttctgt 3535201 ccatttatgg ccgtcttttc cgtacacgcc catattaatg gatggaatat tcagcttgcg 3535261 tatgtctttg aacggaatgg tcccaatcat attccaccca gggaagttcc tgataaaaga 3535321 atcaatttcg ccatcggttt cgtgcagtga taaaaaactg ccgtctgcca agtaggggaa 3535381 aaactttttg aagacaaatg tttcgcctgt cgattcagcg gttttgtcag ccgcttcttt 3535441 aatcacatgc tgcaaaagct gatctcttgc gctatcttct ttcaaatagt tatgcggcag 3535501 gtaaggaggt gcgtaaaata gaatgacttt tgcgccttga tcggggtcaa gcttttgaag 3535561 ctcttcgatt gcctgaaagc atctcatgcg aagttcaagg tgctcgttgg ctttgaatgt 3535621 ctgctcgata cactgctcgg gatctattcc ccggtttctc agcttttcta agtattgctc 3535681 caggctatac acttgaatgc cccatgataa atgtttcttt ggcaggttgg ctctttttac 3535741 atattcttcg taataatctg ataatttttg ttctgtctcc cggcatgctt cctcagtgac 3535801 ttcaataagc aaatccatca tttcttttgc tgttctttca taaataaaac aattgaaata 3535861 caagctggtg ctgacagccg tttgcacatt ataggattcc ttgttatcac gctgatacaa 3535921 acaggatggg ggcagaacca actccccttc aaccttttct gccagatgga tgttattgtg 3535981 gagacggctt gtgatttcag atgaaatgaa atttgggtca atccctgcca gtgtatcgcc 3536041 aacatggact tcacgcccgt aaatgtaaaa gcaaggcaac agttttcccg cggctccggt 3536101 atagatatat cttgtctgat caccatcgta aagcggggta ataaaatccg tattaatagc 3536161 agccaaatag tgaagctgtt tttctttttt tagccggttc agctctgaaa tgctggcgag 3536221 aatgcccgaa tgctggctct cctcatcggg attggccata aacaatacat ttcccggcaa 3536281 cgtctcaagg ttctccgaaa aatgcaggag attggctaaa tgcacggcga tgccgctttg 3536341 catatcgaca gatcctcttc cgaacatcca ctcgcctgat ttggcatccc gctgaacatc 3536401 ctgatcgaac tcatagcggc tgaaatactc ggccaatttc tcacaatcaa aagcgatatc 3536461 ctttaaaggg ccgaaatctt caattccaac tgtatccaga tgggcatggt aaatgactgt 3536521 atttcggctt tctccatgtc ctttaataaa cgcaaaaata tttttgcgtt tgtatgggtc 3536581 attgggaatg gcctgttccc acacatgact ggggttttcc tgaaaataag gatagctcgt 3536641 gatcacttct ttgatgaaat ctgcttttgt cccttctcca acggtgccgt tcacgctgct 3536701 gaggctgacc agagatgctg tcagcgcctc cactctttca gccggattca tgtgactgat 3536761 ttttgtatac tgcataaatt gtcctcctga tcaaaaagtt gaaatcgtgc gatccgctaa 3536821 agaatcgcac gattttattt ctctcaaatc aaaaagcttc ggacgttgtt ttggcttgca 3536881 tatgaagaat taagtaatcg ggaccgcctg cttttgagtc tgttcctgac atattaaaac 3536941 cgccgaacgg ctgatagccg acaattgctc cggtacatcc tctgttaaaa tataggtttc 3537001 cgacatggaa atcctcgcgc gcccgttcaa tgtgcgcacg gtttttcgtc agaagcgcac 3537061 ctgttaatcc gtattccgtg ttattggcaa tctccagcat atgatcgaaa tcacgcgctt 3537121 tgcaaatcgc aacaaccggg ccgaaaattt cttcctgcat caagcgggcg ttttcatcaa 3537181 catctgcaaa gatcgtcggc tgaataaagt agccttttga atcatcgcct tctccgccgg 3537241 ccaatagctt gccttcagat ttgccgattt caatgtattt catcactttg ttgtaggatg 3537301 cttcatgaat cacgggaccc atatacgtat caggatcttc tggattgccg acagtcagcg 3537361 ttttggtcag cgccacagct ttttccacca cttcatcata cacatcctga tgaatgaccg 3537421 cgcgggagcc cgcagaacac ttctgtcctg aatatccaaa tgctgaatac acgatagagg 3537481 atgcagcaag gtcaagatca gcgtccttgt cgacaagcac tgtgtctttt ccgcccattt 3537541 ctgcaattac ccgtttgagc catttttggc ccggctgcac tttggcagct cgctcataaa 3537601 tccggcagcc gactgcacgg gaacctgtaa atgagacaaa ccgtgtcttc ggatgctcaa 3537661 ctaagaaatc accgatctcc gcaccatctc ccggaatgta attcagaacg ccgtttggca 3537721 gacccgcttc ctccatgacc tcgacaaatt ttgctgccac taccggggct gcgtcagccg 3537781 gttttaagag aatcgtattt cctgtcacaa tcgctgccac cgctgttccc gccataatcg 3537841 cgagcgggaa gttaaatgga gaaatgacga tgccgacgcc aagcgcttcg taatgatatt 3537901 gattgacctc gccagcacgg ctcttcaccg gagccccttc cttgagcttt aacatttggc 3537961 gcgcgtagaa ctctaaaaag tctatcgctt cagccgtgtc cgcatctgct tccttccacg 3538021 gttttcctgc ttccttcaca agatagcttg aaaattcatg ctttcttctg cgcaaaatag 3538081 ccgctgcctt aaagagaata tttgcgcggt gctccggtct ttgttttttc caggaatcaa 3538141 atgcctgcaa tgcggcttgc atcgcttttt cagcaagctc ttgatccgct gtagacgcgt 3538201 acccaatgat ctcttcttta tttgccgggt taatagaaat gattttgcgg tccgtttcaa 3538261 ttttttctcc atttatgaca agcggataat gcttgccgag ctgagtgttt acaaaggcca 3538321 atgactcccc aaatgcagtt ttattctttg cttccgtaaa atcggtaaat ggttcgtgcg 3538381 cgtatgtgac tgtcatatgt agtccccctc gtgttatgaa atatatcttc gcatatgaat 3538441 aaaaatgcaa gaatcatgcc attttcttgt cttttgctga aaaaacttgt tgaatcgaac 3538501 agaaatttgt ctaacaggtg atcacctttc tctttttccg atcttgaacg caaatttatt 3538561 ttgcgttttt tgctctttac gcaaaaaaca aatgcaaaat tattttgcgg aggcttctca 3538621 aattagaccc atccgcggaa acgcgatgct tctgccgatt ttctgatgcc cgtcatgtaa 3538681 gccgccaaac gcatatccac tttatgtgtt gccgctgttt gataaattgt ttcgaacgag 3538741 ctgaccatga cgcttctcag tttttctgca acctcttctt ccgaccaata atatccttgg 3538801 ttgttttgca cccattcaaa ataagaaacc gtgacgccgc cggcactcgc taggatatcc 3538861 ggcacaagca gcacgcctct ttcattcagg atcttagtgg catcaatggt tgtcgggccg 3538921 ttcgccgctt caacgacgat tgacgcctga atgttatgtg cgtttttggc tgtgatttga 3538981 ttggagatcg cggcaggcac taaaatatcg caatcctttt caagcagctc ctcatttgtg 3539041 atgacgtcag taaataaatt ggtgaccata ccaaagctgt cccgtttatc gagcaaataa 3539101 gggatatcaa ggccgtctgg gttgtagagc ccgccattgg catcagaaat cccgatcacc 3539161 ttcgcgcccg catcgtgcat gaatttggcc aggaagctac ccgcgtttcc aaagccctgt 3539221 atgatgatgc gcgcgttttg cagcttgatc ccttttttct tcaccgcctc ttcaatacaa 3539281 atcgtgacgc cctgtgccgt cgctgtttcc cgtccttgcg atcctcccaa aacaagcggt 3539341 ttacctgtaa taaagcccgg agaatcgaat tcccgcagcc ggctgtactc atccatcatc 3539401 cacgccataa tctgcgaatt ggtgtacaca tcgggagctg gaatatcctt tgtcggaccg 3539461 acgatctggc tgatggcacg gacatacccc ctgctcagcc tttccagttc tccaaatgac 3539521 attgtccgcg gatcacaaat aataccgccc ttcccgccgc cgtaaggaag attggcaatc 3539581 ccgcatttga gcgtcatcca aatggataat gcctttactt cctcttcatt aacttctgga 3539641 tggaagcgaa cgcccccctt tgtcggaccg acagcatcat tgtgctgtga ccggtagcct 3539701 gtgaacactt tgacgctccc attgtccatt ttgaccggaa tgcggacagt gagcattctc 3539761 tgcggctctt tcatgagttc atacatatct cccggataac ccagcttccg aagggcttcc 3539821 ttaatgattg tttgggtaga cagaaataag ttaagagctt ctttttcttc atctttcgag 3539881 acttgctttg ctgacatctt tttcacctca ttgttttttt ggccggctgt aatgtaagcg 3539941 ctttaaaaaa tcagcccgcc aattcctttc ttcattggat tcacccttat catcatgcaa 3540001 gatccgtacc agcttttgaa tccacaaaaa aagagactga aaacatctca gtctctgact 3540061 acaaatctat cgattaacgg ggatcaatca ccagctgcgt ttcagcataa aaactgccga 3540121 ttcccaaacc gtttactaca tcgcctttaa tcgtgtaagt gcctgcgcga ggaagagttt 3540181 tacgcaccat gacaaggtca aattcggatg cgcctaacaa atcaagcgta agcgggagtc 3540241 tgactgtttt tccatcgttt aaaatctgtg tttctttcag tgttcttcca ttcactgaat 3540301 ctcttgtcgt agcatgaaac ccgtcaggaa attgaaattc taccgctcca agagaaagca 3540361 ccgcatttgg tttatatgtc acttcaatat cagaaatggt ccactctttc gtgctgttaa 3540421 ctgtttttgc ctcgattgat gcagactgtg catgagcttg gcccgaagga agtaagattg 3540481 atagtaaaac agctgaactg atgaataatg aagatacgaa tgaagttctt tttagcatga 3540541 catttccccc taattgattg ttgaaatttg gccagagcgt cctctgcaga aaaagcgctt 3540601 tttcataatt cgcgaattac cagttctttt tcttaaaaat taatctatca tcattttcca 3540661 tggaagtaaa tgttttttaa ggaatattaa cacttggaat tcaatgagaa ttccttcctg 3540721 tttatacaag gttcaaatgg acgatttccc tctctttttc tagtaacatc tgcctgacat 3540781 tttatatctt ttatcctatt ttaaaaaagg gcaaaaaaag tcgaagatgc ctctgctctt 3540841 cgattgatca cgttcctatt tttatctgaa ttcagtgttc cagttaaaac cgatcgtctc 3540901 atcatcccac ggaattcttt tttcatcagg ctgatccggg ttatacgaca tggtggtaaa 3540961 atagataatt gtcagcggcg tctctcccag cactctatat ccgtgagcca ccccttttgg 3541021 gattaataac agcatcgggt tgtcttcgcc catataatag acgtccgttt ctccttttgt 3541081 ctttgaatcc tctcgaagat cgtataggac aacctgagcg tggccggttg ggaagaacca 3541141 gagatcatcc tgcttctcat gataatgaaa tgccttaatc acacccggat agcttttcga 3541201 ccaagaggcc tgcccaaaat gctcaaggag attctcatcg tcccggacca gctcagcaaa 3541261 aaagcctctg tcatcgctat gcttcatcaa ttttttcacc ttgactccat caatcacacg 3541321 cactgctcct ttcctgcaaa tactctcgta acgcttcccg ccagtggcgg gggcggatgc 3541381 cggcttcttc aatagcccga tggctcagca cagagtatgc cggacggggc gttttgttcc 3541441 cgtattcctc tgtcgttaca gacaaaatgg ctgtttccag cccgctttct tccataattg 3541501 ccgtcgcaaa ctcataccag ctgcatatgc ctgaattgct gacatgatag atgcccggcg 3541561 gatggctgaa cagcttgatg accgcttctg ctaaatcctt cgtataagtc ggcgaaccaa 3541621 tttgatcgct gacaacccga agctcttgtt tcgtttcagc aagtttcagc atggtttcaa 3541681 cgaaattact gccgccatgt ccgtacaccc acgatgtcct gatgatcgtg ctgtcttttg 3541741 tcgttaatcg tatcagttct tctccgagcc ttttgctttt gccataaatg gttttcggat 3541801 cgaggggatc gtcttcccta tatggctggg ttcctttccc attgaataca tagtccgtgc 3541861 tgatatgaac atattgagct ccgatgcggg ttgactcaag cgctgtataa taagcgccga 3541921 ttccgttaat caagtacgct ttatcaagct ctttctcgca ttgatcaacc gacgtaaacg 3541981 cggcgctatt gaccacgata tccggctgat aatggccaaa cgaatgccgt actgagcgct 3542041 ggtcagcaat gttcatcatc ttctttgtta acgcaatgac ctcatatccg gcttgcttca 3542101 gctggcggca tagttccaag ccaagctgtc ctcccgcccc agtcaccaat acctttgtca 3542161 atcagatcac cttctcatcg gtcattgtct gtataccact gaatcgtacg cgcaatgcct 3542221 tcttcaaacg tcacttcctg ccgccagccc agttcgtttt tcagctttga tgcattgatc 3542281 gcatagcgcc ggtcatgccc ttttcggtct tccacgtggg cgaacaattc ctcacagccc 3542341 agatgcttca aaatgacact cgccagctct ttattcgtgc gttcatttcc gccgccgatg 3542401 ttatacacct cgccgtcggt ccctttttct aaaatcagct tgatcgcgcg gcaatgatcc 3542461 tccgcaaaca gccagtctcg gatctggagt ccatcgccat acagcggaac aggcaggccc 3542521 tgcttcgcat gacggataat cgtcggaatc attttttcgc tgtgctgata aggtccgtaa 3542581 ttgttgctgc atcgtgtaat gatggccgga agcttgtggg ttttcacata agacaacacg 3542641 agcaaatcag agcttgcttt gctggctgag tatgggttat taggagaaag cggcgtcgtt 3542701 tctgtaaacg cgggatcatc cgcttttaaa tccccgtata cctcatctgt tgaaatatga 3542761 atcagcttct tggcttttcc tttcaagacc gcttccgcca atcggtatgt ccccatgaca 3542821 tttgtggtga taaacggctc cgcttgggaa atgcttctgt ccacatgcga ttctgctgcg 3542881 aagtgaatga cgccatcgta ggtctcgtca aaagcgcggt cgatatcctc ctgaacgctg 3542941 atgtcccctt ttacaaagcg aaaacggctg ttttgcttta atttttccat ttcctccggg 3543001 tggctggcgt acgtcagttt atctaaaacg gtaatgcgcg catccgtttc cctcagcatg 3543061 agctttgtaa acgtgagccc gatgaagccg gccccgcctg taattaaata tgattttgcc 3543121 atcacttttc gtcctgtcct ttccgtaaag cctggtgtac aagctgggaa gcgagataaa 3543181 gcgattcgtg agttccggca tctacccacc agcctgataa cacatcatac gtaagctggc 3543241 tgttttcgat gtatagatta ttcacatcgg tgatttccag ctcgccgcgc tttgatggtg 3543301 atatttgttc aatatatgaa aacacctctg catcatacat ataaatgccg gtaacacaaa 3543361 ggttggtcgg tggctgttcg ggcttttcga tgatggaacg aatccgcttg tttttctcat 3543421 caatctcagc aatcccgaaa cgttccgggt catcaacttc tttcagaagc acttttgctc 3543481 ctttcccctg ctgttcaaag cgttctgtat aaggctttaa tgaatcttca aatatattat 3543541 cacctaataa taaaatgaaa gactcttttt tcgtaaagcg ctttgcataa gacagcccat 3543601 ccgaaatgcc cgatgctgcc ggctgtactt gataagtgat agtaacgcca agctcttccc 3543661 cgttcccaag cagtttgtaa aattgcggca tatgctcctt ttggctgatg agtaaaatgt 3543721 cttttattcc ggcttcctgc agcttcataa tcgaccagta tatcatcgga tacgggccta 3543781 caggaagcaa atgcttgttg acggctttcg ttaagggcat aaggcgtgag ccgtttcctc 3543841 cggctaaaat aacacctttc acattaacac ttccttacat gcatttttat atctcttgtt 3543901 catataaatc ttgaagaata gctgttaccc gtataatgcc tttgccatcc acgagcggcc 3543961 ttcctccctt gtgcaaagaa aggcgaagag gatagctgct cataatgcgt gacatctgat 3544021 agatgagtgt ttcatccggt acaagctcac ccaatccaag atcaagagcg gcgccttggt 3544081 cagcaaatgt tttggctgta gccgtttgat gctcaacctg agaaagaaca aggcacggca 3544141 cgccgatgca aatggcttca tatagagaga tgccgccagc gacaatggct gcgtccgctt 3544201 gtttcatcaa acctgccata tcatttgtct gttcgatcat cttgtactgc ggcttctttt 3544261 cgatccgcct tcggactgcc tcttgatgcg gtgaagcgct ccccatcaca aacatcatgt 3544321 ttttgtcttt tatgtcgggg acttgatcag cggcagccag cactttaaaa ataagctgct 3544381 tcggatcact tcctcctaat gcaacaagga tattgcggca gtctttctta agtgtgtaat 3544441 cctctcttgc ggcctgaaag gcggggtgaa gaataagata gtccggacct tcatagatgc 3544501 gtgtgtttcc ctgaacgtac accctgcttc tgatgtcacc gtaaattccg ttaatgactg 3544561 cgtcactata ttgaatcgat ttaccgtttt tctcttcaaa aagaacaatt ttcgcatctg 3544621 tctccgtctt tattttcttt aacagctctg caggcgcgcc tagaatatca aacaaaagca 3544681 aatcaagctt cttgcttttt atttcccgga gaataaattc gtgctgctgc agctccggct 3544741 ttacgatgac ctgccaatgc tcttcatgaa gaaacgcttc agaatcctga ttcgtataaa 3544801 acgtaatcaa gcatcgctgt ttgagcccct ccgcaagcct cttcatccgg acaacatggc 3544861 ccattccctt ttcatagccg ccgtctgcga agatcccaac atgcatggct agtcagcctc 3544921 tcgttcggtt gccgcatcgg ggttccggtt cagaagggtg ataagctctg aggcggatac 3544981 atcggggcgc tcgcctgctt tttgatagag ggcctttatc gattcatagt cttcctttgt 3545041 atcaatggtc agccgatatt gaggggcgcg aaatcgttcc ggcgcctcta aaaactgaac 3545101 acgataaaga gctggatgat tccttatata taacgtgaca tgctcctgat attgatcctc 3545161 caaagcctga atacggctga tgtcaattaa caggttggcg ttgaccactt cgccgcaaat 3545221 ccctaatggg gcattcagga tatacgtata atccgagcct tgatcaaaat gcgcctgaat 3545281 cattacatcg agcagctcag gatcgacaaa cggattatca cctgttaacc ggatgatgac 3545341 tgacggttta acagcttcta tgaccttcac aaacctatcg aggacacgtt cttcgctccc 3545401 gcggaaaaca cgaaagcctt gtttgataca gtgcgcctct aatatgtcgt cagtttcttt 3545461 gtcagacgtg gcgatgacaa gattatcccg atccttttgg taaaacgcgc tttgccggac 3545521 acggtgaacg agaatatcaa gtaaacgatt cgatccgagc ggccgaagca cttttcccgg 3545581 aagccttgtt gaacccattc ttgcttgaat gataaagaga atatcattca tgaaacgggc 3545641 tgtccttcag taaaatgtca tcccagacaa tgcctgtgtc ggctggaatg tctcttacag 3545701 cccgaacacc gctggtcagc agttcaaaaa atctcgggtg cagcccctgc ggcttttgtc 3545761 cgggccgaag cactgcgata ttgtcttcac taaaggcttc acctttttga atcggagctg 3545821 ttgtaaaaat gcctctgtat gcaaagtttc tgatttctcc ttcgatggcg gtcgttgttt 3545881 tgtatgaact gccaagcagt ttttcagaga ccggctttgt gatcccctgt ttcagctcag 3545941 cttccgtttt cctgatgcca tcgaccattt ctttcaattc atccggattt aatgcaaacg 3546001 agtggtcagc acccggcaga tttttatcga tcgtaaaatg cttttctatc agttttgctc 3546061 cgagccgaac cgcggcacac ggcgcttctg tcggatgctc gctatgatcg gagaagccga 3546121 ttaccgcctc aggaaaagcg gcggcaagca tcggaatgac gctgaggttg ctgtactccg 3546181 gcggtgctgg gtatttcgcc acacaatgca ttatggcaat ttgattgttt ccctctgccc 3546241 tgatggtgcg ccaagcttcg tgaacatcag agatttcagc tccggctgtc gagaaaatca 3546301 tcggcctgtt cagccgggcg acatatttaa gcagcgggag atggttaatt tcataggatg 3546361 cgattttaaa agcgctcggc gaggtagact gaagcagatc agctgacccc tcgtcacata 3546421 ccgtacttaa aaagatcacc tgcttttcgc ggcagtaatc caatagcggt aaaatccact 3546481 cagcaggcat ttccatagat tgaaccaaag aaaaaataga gacgtccttg cccgctgccg 3546541 tcttgtacaa accaggatct ttctggtaca tcctatcagc ttggaacatt tgaaatttca 3546601 cggcatccgc tcccgcttcc gccgcggcgt ctatcagcgc aaaagcctga tcaagcttcc 3546661 cgtcatgatt aatccccgcc tcagcaataa taaaaacagg agcgtctttg cctacagttt 3546721 tattcgcgat ctgaaacgct gccattattt cgcctccttg cccggccaaa tatgataata 3546781 gtaatacgat tgttcagcgg tgaagcccat tcgttcataa aggcggatcg cccttacatt 3546841 gtgaagctgc gtccccgctg ttaccgttct atgcttctgg gtctccggtt gttctatgag 3546901 attcgccaat aaatgaaacg caatacgttt cccttcaaat cccggcttta cagccatcaa 3546961 atcgagaatg cactcatcat ctcttgataa gccctgaaga tagccgatga cctcgccatt 3547021 gtgtttagcg acaatattga ccgccgccct tccattcaga ttgtttcgtg tccactcctg 3547081 aaatatttcg tttgctgcat cgcggctgag atgaggatcc tgaaaatatc tgctttttgt 3547141 aaacgagtct cgggccagct cacatatcgc ttctgtgtct ccgggctcag gcgggcccag 3547201 ttcaaaaaat ggcggtgttt tgtcataaaa agacggaggc atcgccagct tcagcaaact 3547261 cccgacaaag taagaggatg gctgctgttg tatcacatgc gcggctccga tatcttcagc 3547321 cggaacacgg acaaagataa aatccgtttc atccatttgg cgtacagtat aaaaagcttc 3547381 aaacagcctc tttagctgcc cggtactatt tgccgcaaga agtttgacgt tcatgacttt 3547441 cttctgaagc accttgcttt cccacaaaga atcttcgtaa agcaatacgc cttggagcct 3547501 gctgttttca aaaaggccga gggaaaattg atacggaaca tccaatgtaa gctttctgct 3547561 ttggagaaat tcctcaattg cctctttgga gacattttct tttaccgtat acacttaatc 3547621 agcccctttt acgatatccc gcacagcttc aatgacatca tctacatcat cgtcagacat 3547681 tgatggatag agcgggagag aaagggttcg tttatagtaa ttcatggcat tcggaaagtc 3547741 cgcttcctta tatccaaatt gcttttgata atacggatga atgtgtactg gaataaaatg 3547801 aacgctagtg ccgatattgt attcatcctt taaagccgta atcatttcgc tgcgcgtaac 3547861 cccggccttt ttttcatcaa cttgcagaac atatagatgc caggcgtgcc tgccgtcatc 3547921 atggacaaac ggcgtgatca gcccaggaat ctgctgaaaa gcggtttgat agcggccggc 3547981 aatctcttct ctccgtttct gcatatcatc cagccgtttc agctgatgaa gtccgagggc 3548041 cgcctgcaaa tcaaacatat tcatcttata gccgggcgat tcgacttcat agtaccagct 3548101 gccatttgaa gaataacggt tccatgcggc tttactcatg ccgtgaaggc ttagcacccg 3548161 tatcttatcg gcaagctcct catcatcagt cgtcagcatg ccgccttccc ctgtcgcgag 3548221 gtttttggtg gcgtaaaagc tgaatgccgt tgcatccccg atagaaccga tcattctttg 3548281 cttataagtc gtatataccg catgtgccgc atcctccagc acgaataaac catgattttg 3548341 ggcaacagcc aatattgcat ccatatcgca ggactgcccg ccaaagtgga cgggcacaac 3548401 tgctttcgtt cgcggtgtga cggccgcctc aagctttacc gggtcaatat tgagcgtgtt 3548461 ttcgtcaata tccgcaaaca caggcgtcgc tcccgtatga ataatcgtat tggcggtcga 3548521 gctgaacgta agcggagagg taatgacctc gtccccgggc ccaatccctt ttgctttcaa 3548581 agccaaaaat aaagctgcgg tacatgaatt caccgccacg gcgtgcttcg ccccgacaaa 3548641 cgcggcaaac tctttttcaa actgctgaac cttcgggcct ttagagagcc atcccgattc 3548701 aagcgtttct gtaacctcct gaatttcttc cttaccgatt aacggcaatg agtaagggag 3548761 aaaatgattt ctcttttgca ccatttcttt gcgctcctat cattttattc agtatcttcc 3548821 cgcctgtaat caacccctgt tttggctttc agttccgcaa ataaagcatt tgttgattct 3548881 gccaccggat aattagccgc tatgaatgcc aggcgcgcct cttctgcttt ttgatgcacg 3548941 tcgggacttc gaagaacctc aaccaaggtg tgcgccagtt catccggctg gtcaaacata 3549001 aaatcgccaa gagactcata atacggatac gagcgatttc cggacgattt tcctatcagc 3549061 acaggctttt gaaacagcat ggcttcaaga ccgactgtcg aggtttgcgt cactgcggca 3549121 tcaacatacg gcagcaaatc ataaagctcc agctcctttt tgatgactct gcatgcttga 3549181 tgttttttcg ccgcctcgtg atacagatca agcttgtttt ttccgatttc ccacgggtgg 3549241 ggtttgataa tgatttgcag ctgcttctga tcagaaagcc cctgcagcac accggaataa 3549301 aagtcttctg aaaagggctg agtggcaatg agcacaattt ttttagtcgg ctgaaaagca 3549361 agttttcgat agaatatgga catatccata ggcgttctgt taaaaatctg atcgaagcgg 3549421 ggatgtcccg ttacgagaat ctgctcgggt ttacagcctt ttcgtatgaa ccactctgct 3549481 tcatacgcac caaaaacagc ttgataggtt gtaaaaacag gaatgaaggc ttcatctccc 3549541 atcaatgcgc catgctgaag acaaatgctg acggcccctt ttctttgaca catgagagcg 3549601 agcaccctgc tgtaaatgtc ttctgccgtt ccgacaataa cagctgaaat cttttcctgt 3549661 tcaaacagcg catcaactgt atcaatggcc tctataaata aaggaatatc tttgaaaagc 3549721 cggtcgcgaa acgcttgatc accaaatgcc gggtgatcat cataaggggc gagaagcgaa 3549781 caggctgttt cgagatactg cttcgaatcg cctttttggc atgaatccgc aatctcccgc 3549841 ttgctaatta caggcagatc acaataatgc ggcaaactcc atctggccaa aacagccgtt 3549901 ttttcaggat caaattgata gtaattttcg tttgaaaaac gcaggtaatc aaagtgcaaa 3549961 atgactttcc ctttaacagg ttcgtcattt gttttaacga tgttttggat tctttcttca 3550021 aaaaacggct gaatctgtcc ctcatcgata tgctgatcca ccgatccgaa taattccggt 3550081 tcttcttcca tcatcaccct cagttcaggg ctgatgtatt gataaaaatt actgataagc 3550141 ccaagcggaa tccctttgta gcgaagtttg tcaaaaagct ccacgtactt ccggtacagc 3550201 acccaataat tgcttaaata ggccgacaag ctctcacccc attccaagct tttttaatga 3550261 ttcacgcagc tctcggcaat ttcgctgcgg aggaaggttc ctgacaaatt catttttttc 3550321 taattcaaac agctgaaagt gaatcgattg gtcggtaata taattcaggt ccagctcctc 3550381 atccagtggg taaaacggat aaaaatgatt gactctccaa aagaaccggg catctcctat 3550441 acggtaaaac gccgggcttt catcccaata ggagccaaac ttctccttta ccttctcaag 3550501 caccgaatac ctgtgcatca ccgagcaatg atcaattgcg cacggcgcgt tccatgtcac 3550561 ttgagcggca ggcctgacag tttcttttac aatgtcacga ttctcgttta aatgataggt 3550621 tttggaggct gagtaaatca cagccttttc aggatgggta tcgagctccc gcaccatttt 3550681 caggaggcgg tccggcatat agatgttgtc atccgtcgca taggtgatat attcaccctc 3550741 cgccatctca atcgcctgat tgatcagtgc cgcgtatctc gttttttctg ttctttcctt 3550801 cactccagat atatcgcttt gataaaaacg cactcggtta tcattcaaaa aaggacggat 3550861 tacattcagc gtctcttcat tggagttgtc atccataata aacaattcaa aatctgaaaa 3550921 cgtttgtgag agtatgctag aaatggactt tgccacataa tcgcttttgt tatagctcgt 3550981 cataatgact gatactttag gcaaatccta cacctccttc ttggaacttc acacctgaaa 3551041 ctatcgttat cttatgttgc ttatgctcaa gttgcgctag ggatacaaac caatatgcga 3551101 aaagtttgtg tatgtttctg aaaaacagcg gctgcccaga gcgaaatctg atcggtccgc 3551161 tgttcttttt cagcataatc caagcatcag cctcataagg tgaaagagat aaaaatcgca 3551221 ccagcgacta agatcgtttt ccatcggagg tgagtcatcg cggagcgttc acctatacat 3551281 ccagaacatg ttttgaatgg ttttcataaa aaggaggaac gatatgaaac cgaaaaaaaa 3551341 tcaatatcag caaatgcagg catttgataa tatgcagggg tatcagcctc agtttggcgc 3551401 caacccgtac ccgcagcaag gccaaggctc acaaatgcag acaatgggga tgcagccaat 3551461 gatgccaatg cagcagggac agcaaggaca acaaggacag cagggatttg gattcccggg 3551521 ccagcagcag ggcggcggtt ttcaaattcc atcggggcct acaccgtcag gaccgggcca 3551581 aagcgttccc ggcatgctgc ctgttgagga atcttacatc gagaatattt tgcgcctgaa 3551641 tcggggaaaa acggccacca tttatatgac atttgaaaac agcaaggaat ggggctcgaa 3551701 gatttttcgc ggcgtcatcg aagctgcggg ccgggatcac attattatca gcgacccgaa 3551761 atcaggaaca cgctacctgc tcctgacaat ctacctcgat tacattacat ttgatgaaga 3551821 aattgcttat acgtatccat attccatggc gtcctattcg ccaagataag aaaaaagcca 3551881 atcactcata tgatgaggat tggctttttt gtttatagat atttgacggc tgcgacaacg 3551941 atcataatcc aagaaataat aaacgccaca ccgccgagcg gggtgatcgc tccaagaatg 3552001 gagatttgcg tcacacttag aatatataag cttccggaaa acagcacaat tcccgcaaac 3552061 atcagccagc cggctgtcgt gacactgcct atgccggata atttatcagc cagaaacgcg 3552121 acaacgaata acccaagggc gtgatacata tgatactgca cgcctgtgtg ccaaacctga 3552181 agatacttat caggtatttt cccttctaat ccgtgagcgc cgaatgctcc gagtcccacg 3552241 gcaagcaggg cgttaatggc ccctaatatg ataaaaactt tcatctatct ctcccgcctt 3552301 ttcgttaaac tcatatcatt tatcttatcg cacctgcacc aaaattcaat gtttgttctc 3552361 cgttgacacg agattgtcgg attttctcct gcgccaaagc tggaactggt cagctgctat 3552421 tgcagcaagc gtccctaata cgagcccgtt gcttaataga gaaataaata ccggatgcaa 3552481 tccctttaac gcagtttcag gaacaaacat gataccgacc cctgtcagca gtgagatacc 3552541 gatgatagac ctcacccttt ttgattcttc tttctcatat gaatcaaatt cggcaaaggc 3552601 cagaccgccc attgcggaga acacaacaaa attcaccgca aatccaacgg gtgacggcag 3552661 gctcgcaaac gtattcataa aaaacgggat cacgctgatc acgataacca gaatactgcc 3552721 gagcataaac ggttttttag aaggcatctt ggtcgtttca ataaaacctg cggctcccga 3552781 aatcggaaca ggcgcaatag ctcccgtcaa accgctaagc agatggctga atgaagctgc 3552841 aaaaccggca tggcgttcat gatgctttcc atcaggctgt ttgctgaatt ttttcatggc 3552901 gatgtccacg accttcatgc tcgccagcat attcacgatc agcaagatgg taataaaaat 3552961 agaagtgatg atcaggccgc tgttaaataa cggggtccca aaaggaaaca gggaaggcag 3553021 ctgaaacagc cggtccggca tttcaatcgg ctttgcggct ccggcagccg caaacagcac 3553081 ccacccgccg aacaaggcta ataaaataga atattgctta aaaaacatga tgttcgaatt 3553141 tgtcattata aaagcggcag cgatcacaac aagcgccagg ccaaatacaa gaccgtccac 3553201 cccgtcctgt cgataaccga ttccgagaat tccttttata atgggctgac tcagctgcat 3553261 gacaagaagc aataaataga cgcccgttac aaccggagta aacaattttg caagtctgtc 3553321 aatgaccttg aaaacactta acaaaaagaa acatacagcg cttacaagaa gagctccctg 3553381 caaaccccgc agtgtgtctc catatgtcgc aaacacagtt cccgtcagcc ctgcgtaaat 3553441 cgtatacact ccccaccaca agccggctgg gctttcattg atcggcagtc tgtggccttt 3553501 caaacactga atgacggcgg caattcccag tacaaaaaaa gtgctttgaa tcaatcttgc 3553561 agaatctgag tgatccagat gaaacgactg ggcaaccgcc accggaacaa caatcgccgc 3553621 agcaataata aacgctgtcc attgcagcgc gccaagaacc aatttcacgt aagctcaacc 3553681 tctctcttta aaaatcaaat aaagactctc cgtttccatc ctcttcctgc ttctcttttt 3553741 cttgctttcg atatttgttt aatcccgcgc tccccatcat tttttccatc atcagctggt 3553801 ctgtcgatgg cggcgcggcg ggacttggcg taacgctcgg ctgtatgcgg ggcgcgctcg 3553861 cgttctccgg ctgatcaagc acgacatcac acagagaacg gacaaccgct acataacgct 3553921 tcagctcctc atcccgttca gccgtttttg ctttttttag ctcttcttcc atcttttgaa 3553981 tcaaagcaga tatatgaatg ttcatgaagc accctccaaa aaaataaatg ttgtcttcct 3554041 gcattttatc aaattcctgc tgaaaacgca gatatgagtt tgttattttt tctgacaaac 3554101 cttgcgcgat tgacaagcag aagagatttt tcacataata aatcaccata ccttacaaaa 3554161 aggagaaacg gaatgaacag catcccctct atcatcagca agcataaagc ctattttgcg 3554221 gcgggacata cgagaccgct tgaatcgaga ctgaacattt tgcgaaagct gaaacaagcc 3554281 gtcagaactc atgaagccga tctcatagcc gctctctacc aggatctcca taaatccgag 3554341 caagaagcat actcaacaga aatcggaatc gtcttggagg aaatcagctt tgtcatgaaa 3554401 cggctgagaa aatggtccaa gccgaaacga gtcaaaacgc cgttgactca tctaggctcc 3554461 aaaagcatca tcatccctga gccgtatgga accgttttgg tgattgcgcc ttggaactat 3554521 cccttgcagc tggcgctttc tccgttgatt ggcgccattg cggcggggaa cacggtcgtt 3554581 ctcaagccat cagaatatac gccggctgtt tctgctattc tttccaaact catcagcagc 3554641 gtttttccaa ctgattatgt cgctatggca gaaggcgggc ccgatgtcag cacagcatta 3554701 ttacagcagc cctttgacta cattttcttt accggcagtg tagctgtagg aaaaatcgtc 3554761 atggaggccg ccgccaaaca attaattccc gtaaccttgg agctcggcgg caaaagtccc 3554821 tgcatcgtcc ataaagatgc tgacattcag cttgccgcca aacgcatcgt cttcgggaaa 3554881 tttacaaatg cgggacaaac ctgcatcgca ccggattatt tatttgtcca cgaggacatc 3554941 aaaacgaagc tcacagaaga aatgaagcgt gcgatcagag aattttacgg ccctcagccg 3555001 gaacggaatc cacagtacgg caaaatcgtc agtgagcgcc actatcagcg gctgctcagc 3555061 tttctgaatg atggcatccc gctcacaggc ggacaatctg atcccaatca tcacaaaatt 3555121 gcgccgacca ttctcgaaca agtgagagat gactctccag tgatgcagga ggagattttc 3555181 gggccgattc ttccgctctt tacataccgc aatatcgggg aagtcattga gaaagtccaa 3555241 tcgcgcccta agccgctcgc cctgtatctc ttcaccacaa acaaagaaat tgagcgcgct 3555301 gttttaggaa atctgtcgtt tggcgggggc tgtgtcaatg atacgttaat gcatgttgcg 3555361 acgccgtatt tgccattcgg cggcgtcggg gaaagcggca tcggcagcta tcacgggttt 3555421 gacagtttta acacattcac gcacaaaaaa agcgtcgtca aacaaacgaa ccgtttcgac 3555481 ttcgcatttc gttatccttc ctccaaaaac gggctgcgaa tgattcgaaa aatactcaaa 3555541 taaaaaagcg cagatcacct gcgcttttta caaatcctta atacaccaat caatcggcgc 3555601 ctctcccatt ttctccaaat aggcattcgc ccgggaaaac ggtctgctcc cgaaaaatcc 3555661 gtttctcgca gaaaacgggc tgggatgcgt cgattcaatg ataaaatgct tggaggtgtc 3555721 gatccgttct tttttcattt gagcatgccg tccccacaaa ataaagataa ccggccgctc 3555781 tctttcactc agcacgtcaa taattcggtc cgtcagtcgc tcccagcctt ttcccttatg 3555841 ggaattcgcc tgtccgcgcc ttactgtcag cacagtattc agcaaaagaa cgccttgctt 3555901 tgcccagctc acaagcgacc cgtgattcgg gatgctgcac ccgatgtcct gctgcagctc 3555961 aagaaagata ttttttaacg aaggcggctg ctttacaccg ggcttgacag agaagcttaa 3556021 accttgagcc tgtcccggcc cgtgatacgg atcttgaccc aaaatgacga ccttgacatc 3556081 atcatatgat gtataatgca gcgcgttgaa aatatcccgg ctgtccggat aaatcgtttg 3556141 ctccgcgtat tccctcttca gcatctctct gagctcttga taatacggtt tctcaaactc 3556201 ttcctttagc tgattccacc agctgtcttg taaaagctgt ttcaagattc aggcctcctt 3556261 acgaacgatg aagtctggaa tagacaggct cgccatccca aaccatttca ctttttgctt 3556321 cccgcctctt catctcaggc tcttcaagca ggacggcaaa gtttttcgtc ggcagctccc 3556381 cgagtccgtg cttttcactt aaacgatcca aatattgctt ccgcttggcg ccaaggtcag 3556441 cagactgatt gtctcccgcg tcactgaagg cataaatcac gctggcgcaa gggacacgct 3556501 tcacccggta atccttggcc gcgcgcaaat aaaaatccca gtcccagtaa ttgtgcacat 3556561 cagcatcgaa atacccgatt tcatcatgca gaaaacgtct gtacatgctg cccgacggca 3556621 cgtatgtaga aaacactctc atatcctcat agtcagcggt ataagcaaac aatttccgtg 3556681 acactggata ccttgttccg tttttctctt caaacgaaac tatttccgca tcagaatgaa 3556741 cgaagtctgc cgtttctatt tcctttgcca ttttctcgat atgccctggc gtaaagaaat 3556801 catcgtcatc acacagcata atgcaatccc cagacgcctc ttttacaccg gcatttctcg 3556861 cagccacatg ccccgagttc ttttctaaat tgatgacagc aatcggcagc tccggataaa 3556921 gtgctttgac cggcacgacc gattccccgg catcattcac aataataatt tcatacggca 3556981 tcaaggtctg gcgggaaatc gactccaaaa gctcacacaa agccggaatc cgattatagg 3557041 tcacaattac gatagaaatc ttcatgatgc tctccttctc attttcatag tcatgtacta 3557101 ttaaaacata tattggacgg gagatcagtg ggaatatcct actgaaacgg catactacaa 3557161 tgatagaaac agcaaagtgg ctccgatcag aagcaccatg atcagcatca gatctccaaa 3557221 gacatgaaag atatctttca tgcggacgcc attcggaagg ataagacgcc acagcttaga 3557281 ttgatagacc ggcagcagca ccagtgcata agaaagacac aaaaatgtaa aagccggcgg 3557341 cacaaaagca cagcctgcat cgtcccaatt catcatgatg tctttcatac tagatccatc 3557401 caataaaaac aaagatatca tgagggctag caacacaaag gaccccaatt gaacctcaaa 3557461 caggcgcatt ttctggttat atgcaaatcg gaccgcccaa aaccagacat aagcatatga 3557521 acatagcagc gtaagaatgg cacctgctgt aaagacgaca tcaggcagcc gatcaagcag 3557581 aaaaacaaaa ggcaagctgg ctgccatagc caagagcatg cagccaccag taaacaaaaa 3557641 tactgcccca tgagctacaa aaccatataa acaagagcta atcctcacga catacacctc 3557701 ctttacatag aaattctatg tatataccta aaaaatcaga caagctgacg cctgccaata 3557761 taacagccca ttcggccaaa taacggaaat aacagcgttg caaaagcaca agttccaaca 3557821 aaccaaggtg tcaacaagga ttgaaacagc gcagcaggaa ttacattgaa tagaaaaaca 3557881 agcataaaaa tgacgtttgg caccattgag atcagaatcg tatgtagaac aagcttttct 3557941 ccgcgttttc caaactcctt cacgccttga tacccaatca gcacccagta gatcatatat 3558001 gcagctaaga tcagccaaac agaaacagaa atgcctttcc atactgcttg aacaaacggt 3558061 gattcaagcc atacatgcat tattgtaatc gcaatgccga cagcgaatag ggcactgtta 3558121 cagaaaagat ggaacatcaa aaacgcacga aacgttactg gctgtatttt cttaaacgaa 3558181 gaaacaatgt cagttggtgt tccaaacgcc tgcaataaag tctgcatagc ttcctcctca 3558241 ctctttcctt cctgaaaaga gcgaaacaga tgatgttcaa tatggctctc aatctcttct 3558301 atcatcgcct caccctcagg aagcccttta agcccgcttt tgatttcgga tacatatgtt 3558361 tctttatcca ttttgtccgc tccacttcag tattcggtcc atcatggctg aaaatacgct 3558421 ccattccttc gtgcgttccg ccagcacttc tttgccctcg tctgtaatcc ggtaatattt 3558481 gcggtccggt cctttctcct gcttctccca gtaggaagaa atataccctt ggcgttcaag 3558541 cttgtgaaga gaaggataca aggtcccttc tttcatctgc agttcatttc cgctgcggct 3558601 tcccatttct tttacaagct catagccgta catcggccgc tcgttcagaa gcgtcaatac 3558661 caatataacc gtgcttccct taaccagctc acgatttaac atctcaaaac ccctacctag 3558721 ttttcttatg tagcatttta cgaaagcccg ttgagattgt caaatgattc ctatagatct 3558781 tctatattgt gatacagaga aaatctaact ataatgaaag acaaaacatg atggaggttc 3558841 aagacatgtc tatgcataaa gcactcacca ttgccggctc agattccagc ggcggtgctg 3558901 ggattcaagc tgatttaaaa acatttcaag aaaaaaacgt atacgggatg accgccttaa 3558961 cggtgatcgt tgcgatggac ccaaacaaca gctggaacca tcaggtattc ccgatcgata 3559021 ctgatacaat ccgcgcccag cttgcaacaa ttacggacgg catcggcgtg gacgccatga 3559081 aaacaggaat gctgccaacc gttgacatta tcgagcttgc ggcaaaaacg atcaaagaaa 3559141 aacaattaaa aaatgtggta attgacccgg ttatggtttg caaaggtgct aatgaagtcc 3559201 tttatccgga gcacgcccaa gccctgcgtg agcaattggc tccgctagcc actgtcatta 3559261 cgccaaactt gtttgaagcc agccagctca gcggcatgga tgaactaaaa acagttgacg 3559321 atatgatcga agccgcgaaa aaaattcacg cactcggcgc tcaatatgtc gtcattacag 3559381 gcggaggcaa actcaaacac gagaaagccg ttgatgttct ctatgacgga gaaacagcgg 3559441 aagtccttga aagcgaaatg atcgatacgc cttatacaca tggcgcaggc tgtacattct 3559501 cagcagccgt gacagcggag cttgccaaag gtgcggaagt caaagaagcc atttacgcag 3559561 cgaaagaatt catcacagcg gccattaaag aatccttccc gctaaaccag tatgttggtc 3559621 ctacgaagca ttctgcactg cgcctgaatc aacaatcata aaaaaagggg ctgccttaca 3559681 gagaggcagc cctttttaaa tcaccgaaga cttttcacag aaaaaactgc cgatcccatc 3559741 ggcagcctgt ttatttgatt tttaaattgt ttgcagattt cctcaaaaat gtttctatcg 3559801 actgaacaaa aagtgcatat tccttcattt gttcatatgc ccgcgtgaga atttccgccg 3559861 tttcactgtg cggcgttgtt ccgccaagca tttttttcag ctgaagcagc acatccttat 3559921 attcttctcg cttatcttca acttggttag cagccttttc caaacattcc ggtgttatct 3559981 tctgttcatg tatattcaag aaaacaactc cttttacaga aaaaaatagt aggttatcgt 3560041 tgaagaatag cacagatggc tcagatttca cataagaaaa tagaaggatt ttctacataa 3560101 gtgtccaaat tccgacattc atttcagatt tcccggtcgc actggctgtt acttcatgat 3560161 ttcccgggaa aggaaaatat cttgcactca agacctcttc tccgttattg ataaagattt 3560221 ccacagatga cgcgtcgaga aacatgtgta cggtatgcaa atccttgatg cggcaatgtc 3560281 tcgcttctgt tctttttccg tcaaagctct ttcgttccag cgtaacaatc ccctcgtctt 3560341 tatggaagga aaacgtagcc gttccgcgga tactgattga aaagccagac tccgtatgaa 3560401 tgtcttccag tagaatctca gttctttcag gtttttccac tggaagcgca ccagatgatc 3560461 catgcatgtt gatgtgtatt tttttctcat ttctgcgcat ggcttttagc tcaggcagcg 3560521 gctgctgaat cagcttctgt cctgaaagcg tcagctgtct cggcagcgtc atgcagtgaa 3560581 tccagtggca gtcaatggtc ggatgggacc cttcatcctg atcaggcacc gccatccatg 3560641 caaataaaat ccgccttccc tgatcgtctt caagtgtttg cggcgcgtaa aaatcaaaac 3560701 cttgatcaag ctccgtaaat tcaccatgct tcagttcagg cttgttataa tcgaggcggc 3560761 cgacaaaata acctgattga tatacgttct gataacggaa accgtcagcc tcaagccctt 3560821 gaggcgaaac aatcagcaca tccgatcctt gaagggaaaa caaatcaggg cattcccaca 3560881 tgtatccaaa atcgtccagc ccgttgaagc ccgcgccggt tatcgggcca agaaatctcc 3560941 actctgtcag gttatcagaa gcaaacaaca cagcctgccc tttcaaattc tctgtttgcg 3561001 caccaatcac catataccat gtgccttcat gctcccatac cttcggatcg cgaaaatgcg 3561061 ccgtatatcc ttccggaagg cgggcgacga cacccttttt ctcaaaggac agcccgtcgt 3561121 cagaaacagc aaggcattga tacgtttccc gatttccatc ctgatccctg acatttcctg 3561181 tgtaaaaaag atagagccga tcgtctttcg tgacagcgct gcccgagtag cagccgtttt 3561241 tatcaaacca atcactcgga gccagcgcaa tctcttcccg cttccaattc acaacatcct 3561301 gtgtcgtata atgcccccaa aattttgcgc cgtgccccgt ctgaaacggc tgccactgaa 3561361 agaatacatg atagctgccc ttccaataaa tcacgccatt cgggtcattc agcagcccaa 3561421 ccggcggcat gatatgaaaa tgctggcggt gcggatcgct gttagcgatg ggctcttttt 3561481 tctccacttc ttcataagcc cggcgacgaa gctcctggtc atgtgctgtc attttttcct 3561541 ctcctcatcc tcattaatct tcatgacaaa tgctgcaatg aacgctgaca ctgccgcaat 3561601 cgccatgcca atcagatagt gaatcaagtt gctgaagcca aacggagccg caatggcgat 3561661 catcggaatt cccgttaacc cgtaagcgtt tgcagctaca tgtgtaaaga cgacatatgc 3561721 cccacccaat gcgcctccga tcatcgcggc gataaacggt tttcggtagc gcagattgac 3561781 tccgaatatg acgggctcag taatgccgag aaaagcggaa aatgctgccg gaagcgcgat 3561841 ttcttttgtc tttgcctttt tcgccataaa gaagacggca agacctgccc cgccctgtgc 3561901 gacattcgcc attgaccaga tcggcagcaa gtagtttttg cctatatctg caattagccc 3561961 tgcctcaatc gcatggaagc tgtgatgaac gcctgtcagc acgatgagtg aatacgtgcc 3562021 cccgaaaatc agacctgcga caaaaccggc atggtcatat acataagtta aagcaaccgt 3562081 aatgccggag ccaagcgctc tgcctagagg gccaatcgcg ataaaagcaa caaacccggt 3562141 gacaatcaca gtaacaaatg gtgtaacaag caaatccacc gcatgtggaa ccacttttct 3562201 cgtccatttc tctaccttgc tcatcacata caccgcaagc aggacaggga taacagttcc 3562261 ctggtagccg agaagagcga tatcaaatcc gaaaagatgc atgtaatcag gtgtcgcttc 3562321 cgccaatccc catggattta aaagattcgg atgaatcatg attcccccga tgaccgctcc 3562381 caagtatgga ttgctgccaa actcttttga agcgctgacc ccgattagaa tcggcaagaa 3562441 aatgaatgct gcacttgaaa acatatcaag cagctgcaaa agcgcagaat ccttgctcat 3562501 ccaatgaaac gcattgatca tacccagcaa tcccattaat aggccgctgg ctacaatagc 3562561 tgggatgatt ggaacaaaaa tattagaaag cgttttcgca aatctcgcag cgggattcag 3562621 cttttctttt gccgcatcct gatgattgac gtgttcttca cgctcgatat cagcttcttt 3562681 agaaaaggca tcgaatactt tattcacaag gcctgttccg aaaatgatct ggtactggcc 3562741 agagctgctg aaagcccctt taacgccatc aagctcttct acttgtgctt gatctatctt 3562801 tgattcatct ttcatcacta aacgcagtct tgttgcacaa tgagccgcgc tgataatatt 3562861 ttctttccct ccgagaagct caatgaggcg ttttgcagtc tctttgtaat ccatctattt 3562921 ctcccccttt tatttaaaca aaaaagacct aaaattcgcc aacgaataaa ggacacagcg 3562981 atcctttttc atttacgcaa attttaggtc ttgcctgctt taccagtcac aatcccgctt 3563041 attcagatta agaatacgct ttcatcataa atcatgatag cgttttcgtc aactattttt 3563101 ttagttaaat agtttgatat aacatgtaga caaaaattcg taaaaattaa ttgtgaaata 3563161 cttcacaata tcgtgctata ctatgctcaa tcatgaaaga aagcaggaaa agacaatgga 3563221 aactcaagca ttacaaaagg ttgaacagta tgctttgaaa aaacaaaaca tattcgcttc 3563281 aagcaaaatc cgttatgtgc ttcggtccat tttggccagt atatttattg gttttggcat 3563341 tacagccgca agcaaaacag gcagctattt ctttatggct gattctccgt ttgcctttcc 3563401 ggcagccgct gtcactttcg gggccgctat tctgatgatt gcttacggag gcggagattt 3563461 atttaccggc aacacctttt atttcaccta taccgcgctc cggaaaaaaa tcagctggcg 3563521 cgacacccta tacttgtgga tgtcaagcta tgccggcaat ttaatcggcg ccattctgtt 3563581 tgccatcctg atcagcgcga cgggactttt tgaggagcct tctgttcatt cctttttgat 3563641 tcatttggca gagcacaaaa tggagccgcc ggcttccgaa ttgtttttca gaggaatgct 3563701 gtgcaattgg cttgtgtgcc tcgccttttt cattccaatg tctctcaaag gggaaggagc 3563761 aaagcttttt accatgatgc ttttcgtttt ctgcttcttt atttccggct ttgaacacag 3563821 cattgccaat atgtgcacat tcgccatctc gcttttgatc gagcaccctg atacagtgac 3563881 actgatggga gcagtcagaa acttaatccc cgttacgctc ggcaatctga ccgcgggaat 3563941 agttatgatg ggctggatgt actacacact gaatcctgat caataaaaaa acttccagag 3564001 atcactccct gcaagtcaaa gcggttattc cgagagatct tgaagacgct ggacatgcag 3564061 cgtgatatag ccggcctcgg attccggcaa atgtaattga tattcatttt tcaaaaactc 3564121 cgccagctcc agcgcacatt gataggcgaa tgaatacttt ttttggatga aataaagcat 3564181 ctcctcgtcc atacgatgga gcgcttcatt tgattccaac cggctgaccg cgtatcgcaa 3564241 atgcgtgaca aggcgttgat aggaaatgct gttttcatcc acctttcgat taaagtattg 3564301 ttttattttc tctatcattt ctttgatcat ggtcgtatgc ttcagcgctg aatacatgct 3564361 ctccgcatcc atcttcgccg tatggatgtg aagggcaata taacccgctt catcttcagg 3564421 cagagacacg cccaatgtct cttttacatg tccgatcgcc cacaggccga tctcatattc 3564481 ttttttatag agcgccttta tctcatgcag caatttattc tgcacaagca gcccattttg 3564541 aatcctttcg atcgcaaagg acaaatggtc ggaaagcgcg atatgaatgt gatcgctcag 3564601 cggcgccgcg agctctcctt ccgcatagct gatgatatcc tcagctattt ctatatgctc 3564661 ctccggcagt gtttgcagga tttgtttgaa cttttcattc tcgtcgcgca cgacaaagat 3564721 cttttccact ttattcatag ggatgagatc atttttcttt ttttgaaaag cgattcccgg 3564781 tcccatcacg attttttcct gatcatcctc ttttattaaa gccgcattgt tgtttaatac 3564841 tttatagatt ttcaagaggt tatctctccc gccaatttgc ttttgactgg gattttacct 3564901 ccttttgacc gccatgtaaa gatgcgggcc cgctctctcc tgctttggcg attccttgaa 3564961 ggcttgcaaa catcttcttt tataaagcgc ggcggctttc gctttctgct tttcttcctc 3565021 attcacagcc atccgccatt cataaaacga aacgagtcct gcggcctgca cagccgcctt 3565081 tctttggtat gtacgctgag ccgaatagac cgcggcagcc gcagtttttc tgtccggcgt 3565141 cacccagttc atcaaaaaga ccatccacac ccgtaaagat acaagcaaac gtttcataga 3565201 aaaacatccc tccgcttctt tttggcaggc agccttttta gcagcccgtt ttctcagccg 3565261 cagcccgcaa gaaaagacgg ccgatttctt ttctcgcaaa ctagcggctc tagcaaaact 3565321 catgactcta tgatagaccg tggaaagaga attctttgtc acaatatgag tgaaaaaacc 3565381 aactagtttt tagaagtttt gttgaaagct gaaagaattg aaatgaaaat tggagaaccg 3565441 ctttgaaaac tttatacaca agttatccca aagataagaa caacttaatc acaagagata 3565501 tccacatgtc cacaaactct atctatattt tgtatacgaa cgtatattcc taactatata 3565561 tatacacagg tttattcact tatacacagg gttctgtgta taactccttc gttatacaca 3565621 aacaaaatcc aataaatggt ccaaatgaca caaggatttt tttgaatttt caagaaatat 3565681 atactagatc tttcacattt tttctaaata caaaggggga aacacattga aaaaggggat 3565741 cattcgcttt ctgcttgtaa gtttcgtctt attttttgcg ttatccacag gcattacggg 3565801 cgttcaggca gctccggctt cttcaaaaac gtcggctgat ctggaaaaag ccgaggtatt 3565861 cggtgatatc gatatgacga caagcaaaaa aacaaccgtt atagtggaat taaaagaaaa 3565921 atccttggca gaagcgaagg aagcgggaga aagccaatcg aaaagcaagc tgaaaaccgc 3565981 tcgcaccaaa gcaaaaaaca aagcaatcaa agcagtgaaa aacggaaaag taaaccggga 3566041 atatgagcag gtattctcag gcttctctat gaagcttcca gctaatgaga ttccaaaact 3566101 tctagcggta aaagacgtta aggcagtgta cccgaacgtc acatataaaa cagacaatat 3566161 gaaggataaa gacgtcacaa tctccgaaga cgccgtatct ccgcaaatgg atgacagtgc 3566221 gccttatatc ggagcaaacg atgcatggga tttaggctac acaggaaaag gcatcaaggt 3566281 ggcgattatt gacactgggg ttgaatacaa tcacccagat ctgaagaaaa actttggaca 3566341 atataaagga tacgattttg tggacaatga ttacgatcca aaagaaacac caaccggcga 3566401 tccgaggggc gaggcaactg accatggcac acacgtagcc ggaactgtgg ctgcaaacgg 3566461 aacgattaaa ggcgtagcgc ctgatgccac acttcttgct tatcgtgtgt tagggcctgg 3566521 cggaagcggc acaacggaaa acgtcatcgc gggcgtggaa cgtgcagtgc aggacggggc 3566581 agatgtgatg aacctgtctc tcggaaactc tttaaacaac ccggactggg cgacaagcac 3566641 agcgcttgac tgggccatgt cagaaggcgt tgtcgctgtt acctcaaacg gcaacagcgg 3566701 accgaacggc tggacagtcg gatcgccggg cacatcaaga gaagcgattt ctgtcggtgc 3566761 gactcagctg ccgctcaatg aatacgccgt cactttcggc tcctactctt cagcaaaagt 3566821 gatgggctac aacaaagagg acgacgtcaa agcgctcaat aacaaagaag ttgagcttgt 3566881 cgaagcggga atcggcgaag caaaggattt tgaagggaaa gacctgacag gcaaagtcgc 3566941 cgttgtcaaa cgaggcagca ttgcatttgt ggataaagcg gataacgcta aaaaagccgg 3567001 tgcaatcggc atggttgtgt ataacaacct ctctggagaa attgaagcca atgtgccagg 3567061 catgtctgtc ccaacgatta agctttcatt agaagacggc gaaaaactcg tcagcgccct 3567121 gaaagctggt gagacaaaaa caacattcaa gttgacggtc tcaaaagcgc tcggtgaaca 3567181 agtcgctgat ttctcatcac gcggccctgt tatggatacg tggatgatta agcctgatat 3567241 ttccgcgcca ggggtcaata tcgtgagcac gatcccaaca cacgatcctg accatccata 3567301 cggctacgga tcaaaacaag gaacaagcat ggcatcgcct catattgccg gagcggttgc 3567361 cgttattaaa caagccaaac caaagtggag cgttgaacag attaaagccg ccatcatgaa 3567421 taccgctgtc actttaaagg atagcgatgg ggaagtatat ccgcataacg ctcaaggcgc 3567481 aggcagcgca agaattatga acgcaatcaa agccgattcg ctcgtctcac ctggaagcta 3567541 ttcatacggc acgttcttga aggaaaacgg aaacgaaaca aaaaatgaaa cgtttacgat 3567601 tgaaaatcaa tcttccatta gaaagtcata cacacttgaa tactcattta atggcagcgg 3567661 catttccaca tccggcacaa gccgtgttgt gattccggca catcaaaccg ggaaagccac 3567721 tgcaaaagta aaggtcaata cgaagaaaac aaaagctggc acctatgaag gaacggttat 3567781 cgtcagagaa ggcggaaaaa cggtcgctaa ggtacctaca ttgctgattg tgaaagagcc 3567841 cgattatccg agagtcacat ctgtctctgt cagcgaaggg tctgtacaag gtacctatca 3567901 aattgaaacc taccttcctg cgggagcgga agagctggcg ttcctcgtct atgacagcaa 3567961 ccttgatttc gcaggccaag ccggcattta taaaaaccaa gataaaggtt accagtactt 3568021 tgactgggac ggcacgatta atggcggaac caaacttccg gccggagagt attacttgct 3568081 cgcatatgcc gcgaacaaag gcaagtcaag ccaggttttg accgaagaac ctttcactgt 3568141 tgaataagaa aaagccctgc cgattcggca gggcttttta aagatcagtc agcaaacgcc 3568201 tcctgcaata agcgatacga tcggagctta tcttcaaaat gatgcgtgat ggtcaccacc 3568261 atgatttcct ctgtttcata cgcgttactc aaagctaaca gccgctcctt aacctgttct 3568321 ttcgtaccaa caatcattcg atttcgatta tcagcaattc gtctctgttc ataaggagaa 3568381 tacgtatttt tccgaacagc ttcatacgaa ggaactccct ctaaaggaat accctgctct 3568441 cccgccaaaa gtgtaaaatc aagcacagcc ccaagctcct ctgccttctc ctccgtgtca 3568501 gcacaaagaa caaaaacagc aactgccgct cgaggcgtat ctcctaacac agacggtttg 3568561 aatcgcctct tatactgtct gacagtaccc tctccgccct ctccattgat aaaatgggca 3568621 aacatatagc cagcgccaga ttcagctgcg agcagcgcgc tttctccaga tgagccgagc 3568681 agccacacat ccggagccgt tgaaatatgc ggcgcagcgg tcagattcgg aaaacggtgt 3568741 ttgtcatccg ccaaatcatg caaatacatg gtcagctcct taatttgctg cggatactga 3568801 tcagcattgc gcttaccacc gtcattcagc gcccatgatg caatcggcat tccccccggt 3568861 gctctgccaa gccccaggtc aattcttcct ggtgtcagcc cctccagaac acgaaagttt 3568921 tcagctactt tataagcact gtaatgcggc agcatgactc ctcctgatcc aacacgaatt 3568981 cgctttgttt tcgctgctat atgactgatt agcacctcag gactggaccc tgccagccgt 3569041 tttgaaaagt gatgctcaga aacccaaaat ctcttatatc caaggtcctc agcagcttgg 3569101 gcaagcgcaa cggtttgctg taaggccgtt tctgcattgc tgccctctga tactggagat 3569161 tgatctaata tacttaatga aaccatccct accacctcat cctcatcgta tcactgatcc 3569221 cctatttttt ctccaaagcc gctcacactg cttatcagtg tcccctatca ttcgccattt 3569281 atttgtgaaa gcatgtccct atttgtcgga atatgttaca cgtgaaacat aaaaacccct 3569341 ccagacggag aggtttgctt tagtttttat taaagccctt ttctttcacg tagtcattta 3569401 aatacgtacg cggcttttgc ttcataaagt tcagtatttg atcggaccac gtttcttccc 3569461 gcttcccgtt tgttctttct ctatagtaat cagaaatggt tttgtcatac gtattcatag 3569521 tatgacggaa atcgtctgtg ttcacattat acgtattttc atgataaacg gcctgctttg 3569581 gcaatctcgg ttttttgccg gaaaggttcg caggatggcc tactgccagt ccgaaaagcg 3569641 ggagcacatg gtcaggcgtt tgcagcacct ctgtcacctt gtccaattca ttccgaatgc 3569701 cgccgatata gcaaatgcca agccccatgg attcagcggc aatgctcata ttttgcgctg 3569761 ccagcgccgc atcaatcaag ctaaccataa acatttctgt attctcgagc agctcagaaa 3569821 tatgttcacc tttttcctca gccagttgtt gatggcggta caaatccgca caaaatacaa 3569881 aaaagtgtcc gttcttctca acgtaaggct gattcccagc aagcacggac agctcacgtt 3569941 ttttctcagg atcagaaacc ccgataatcg aatatgcctg cacatagctg gatgtagacg 3570001 cagcctgcgc acttttcact aatgtatcaa tttcttcagc tgtcaaaagc tgatcagtaa 3570061 aagaccggat tgaccgatga ttcaaaatgg tttcgattgt gttattcatc acaaaaacct 3570121 ccttatcact ttttatcata tccgaaaaaa agtgatctca aaagtgaaat gctctgcaca 3570181 aaaaaagaca gcctctgtaa aggctgtctg catatcaaga attaaaaaga taacttctgt 3570241 atttcgtcag ctgcacactt gcattatata caatcccaaa tccgattaac gtggaaagtg 3570301 tcgagcttcc cccatagctg acaaacagca gcggaatccc ggtaacaggc ataatgccaa 3570361 tgttcattcc gatattctgg aatgtgtgga tcacaattaa cgccgtatag ccaacgcaaa 3570421 agaaagaagc gaaacggtta aacggatgta ttttgtctat cagaacaaca agcctgtaga 3570481 ttaaaaagaa gaacatgatg acaacaattg cacagcctat aaagccaaat gactcaccta 3570541 ttatagaaaa gataaagtca gtcgtactct ctggaacata aaccttcaaa ttagaaatac 3570601 cattacctaa aataccacca gatcctattg ccatgatggc ctggtcaact tgccagctgt 3570661 catttgaatc ttcctgtgtc tcatttgaag cagacaccca agaagtgacc cgcttaattt 3570721 gataatcctg tattccaact gatttagcaa cgtcaggaaa gtttatcatt actaataaaa 3570781 ttaatgaaat gagtaagata cctgaaccag ctatgatcgc aatcaatttc caatttatcc 3570841 ctgacataaa aaccattaca agaacgataa acatacatat tcccgcagtc ccagcatcct 3570901 gcatcaggat aagacctaca ggaataactg cgacacccgc aatctttaat aacaagtgga 3570961 tatcatccct aagcgtccga actcctttag gatttgcttt tccaataact gaagcaagca 3571021 tcataatcaa accaaccttc ataaactctg acggctgtat tgttattcta ccgatcctaa 3571081 accaactttt tgccccttta ataacaggtg caatagactc gggactgatt ttaagaataa 3571141 tcaaagataa aataccaatg ataaaaatat ataaacttaa cttttcaagc tgttctaaat 3571201 caaagtacaa aagaactgta atggctacag cccccaaaag ataaaacaca atttgctgaa 3571261 tccaatccgt gttcccatac tgcccaaact gaccggcagc atatattgat actacgctta 3571321 taataaaaaa cacaccaaat ataaaaatca aatccccctg gtaaaagggg ctttgctgtt 3571381 tcttatatcg actcattcta tcccgcctta cattttcatc ggaaaatcac taatgtttat 3571441 tatacatgaa ccacgttcaa gatgacacgt gaagctcgct tccttttatg ttttttcagc 3571501 atttgcggcg ctttttcagc tacacgaaat atgacgtatc ataaaccgaa atgtttcgat 3571561 tgacacaaaa cttttcaaat gaaaaaaacg ccataccaat agaatttgtt aaaaaacgaa 3571621 tgcgataatg tgttatgttc ccaaataatg tgatacctca tatagaaata gctaaaaatt 3571681 cagagcccca tgcccataca ttctcctagc acattaaacg aaaaaataag acgatagatc 3571741 cagtccattt ctgcaaaaac acgtatcaat ttctggaaaa catggtataa taattgtaac 3571801 agaatgttca aaaaacaatc acaaaacaga cacaactcag ttcctctatt tcatttttgt 3571861 aaacgttatc acaaaatgaa aggagacggg tatgatggac atgttttttg cttacttatt 3571921 ggttgccagc gcaacgcctc tctttatttg gcttgataac aaaaaagtcg cactctcagc 3571981 tattccgcca atcattttaa tgtgggtatt cttcttcttt tacgcaacag aaagcctttc 3572041 tccacttgga cacactctca tgattatctt gtttgccgtt aacgtcattg tcgctcatat 3572101 cgccgcattt atcatttacg gccttccgta tcttcgcaga aagcgaagca gctgaagaca 3572161 gcaaaaaacc ctcttccact gaagagggtt ttttgtatta ttcgttatgg cctgaatgct 3572221 ctgagtgttc agcgcctcca ggaggatttc cgtccatatg gtcaccatgg tgatagtgag 3572281 ccgcgaaaat ccagatggat ccaagtacga taacgatcgc gccaaagaat ccgaacagcg 3572341 tgtttccgac ttggatcgtg ccgttttcgc tctctgtcat atgcatgaac atgagaagct 3572401 gcagcgccgc ctgaatgaag gcgaagccga agataatcca aagttttgct gatgagctca 3572461 ggtcagtata cactgcaacc catagagcca gcagggtcaa aacgatagac aggataaaac 3572521 ctacaatgtg tttccatgga aagtgactgt gttcagcaga tttgtttgcc attttacaga 3572581 ccccccaatc ccatgagata gacacctgta aagatgaaaa tccatacaac atctaagaag 3572641 tgccagtaca agcttgagat aaagatttta gatgaagttt gcggagttaa gccgcgtttc 3572701 ttcaactgaa tcagaattcc tgtgatccag aaaatcccga ttgttacgtg agttccgtga 3572761 gttccaagta aaacaaagaa tccagaccag aacgcacttg tactgagagc cgctccttca 3572821 tgtacatagt gaacaaactc gttgatctcg catccgacga agccggcacc gagaagaaga 3572881 gtgataattg tccaaatgac tacgcctttt aaacttccgc ggcgcatttc atgaacagcg 3572941 atcccgcagg taaagctgct gatcagcagc aagaacgtca taatcattac cagattgact 3573001 tcaaatagtt cgtctggcaa gacacctcca gctgttctgt ttttaagaac gaagaaggtt 3573061 gcaaatagtg ttgagaacaa cacaatttct gcccctaaaa agatccaaaa cccgagaata 3573121 ttaagtctgc cggtttcaga ttgatattcc ataggcgcgt tagaattgcc gtgttctgca 3573181 tgttccataa ctcacgcctc cttattcgga aatctttctt tccgtctctt ttatttcatc 3573241 aacactaatg tagtagccgt tgtcgtattc gaatgaacgc agaaccatgc agagcaggac 3573301 tccgatcaat ccgactacgc ccatccagta ccattcaaag acaagtccaa agcctgcgag 3573361 accgaaggca acagacataa agaacggtct gcctgagttg cttggcatat ggattttctt 3573421 gaatttgctt tcagggtata attcagtttt ttcttctttc atatgcagga atgcatcttg 3573481 agatttgact tcaggaagca ccgcaaagtt gtaatgcggc ggaatcgcag aagaagtcgc 3573541 ccaatcaagc gtacgtccca caccccatga atctccgctg atttcacgag tagagtaacg 3573601 gaagctgtag tagatgttat agcaaaggat taagaatcct acacccatca tgaaagctcc 3573661 gactgttgag ataaagttca atgttgtcca gccgtcattc ggtccgtatg tgtaaatacg 3573721 gcgcggcatg ccttgaagcc ccaagaaata ttgcgggaag aaacaaatat tgaacccgat 3573781 cataaagatc cagaagaacc attttccgat tctttcgttc agcttgtggc cgaacatttt 3573841 tggataccag aaaataaatc cggcgaaaca agcaaataca gtacccgcaa tcagcacata 3573901 gtggaagtga gatacaagga agtacgtatt atggtattga taatccgctg ctgccatcgc 3573961 aagcataacc cctgtaaccc cgccgataac gaagttagga atgaacgcaa gcgcccacag 3574021 cataggtgtt gtaaagctga ttcggccttt atacattgta aagagccagt taaagatttt 3574081 aaccccggtt gggattgaga ttgccattgt cgtaattgag aagaatgagt taacggacgc 3574141 actgttcccc attgtgaaga agtggtgagt ccaaactaag aaactcaata cagagatggc 3574201 gataatagaa ccaaccatcg ctttgtaacc aaacaattgt tttcttgcaa agcttgagat 3574261 gatttctgag aaaataccaa acgccggaag aataacgata tatacttcag gatgtcccca 3574321 aatccagaac aagttagccc aaagcatcgg cataccgcct gcttccaatg tgaaaaagtg 3574381 agcgccgaac aaacgatcaa atgataaaag tgctaatgct actgtaagta cagggaacgc 3574441 aaacacgata ataaccattg tgatcagtgt tgtccatgtg aacatcggca tacgcattaa 3574501 tgtcatgcct tttgttctca tttttaagat tgttaccata aagttgatcc ctgtcatcag 3574561 ggtaccgata ccggcaatct gaagtccgag gaggtagtag ttctcacccg gcccagggct 3574621 catgtcgtta cttgcaagcg gcatataact cgtccagcct gcgttcggag aacctccgat 3574681 aacgaaagaa atattgaaaa gcatcgcccc tacaaagaac gtccagaagc tcaggttgtt 3574741 caagtaaggg aacgcaacgt cgcgggcacc gatttgaaga ggcacaacaa cgttgataag 3574801 accgattaag aacggcatcg ccatgaagat gatcatgatt gtaccgtgag ttgtaaaaat 3574861 ttcattatag tggtttgagt ctaaaaaact gttattcgga agcgctagct gggcacgcat 3574921 catcagaccg tcgacaccgc cacggaataa cataattaca gcagatataa tatacatgat 3574981 tccgagtttt ttatggtcaa cagtagttat ccattcagac cacagccatt tccacttttt 3575041 gaagtaagtc agaacaaaaa taatggcaat ggttgaaagc gcaatggaaa cttgtgcgcc 3575101 cagaattaat gggtcaccag ttacgaaaaa ttcgtcccat ttgaatttca tgcaggcttc 3575161 ctcctttcct gatcaatatc attcttctgt atcatcagac ttcttaaatt cgtttttctt 3575221 tacgttttca aacggatctg ttttagaatg cggtgaaacg gcttgatagc caaggcgttt 3575281 gcgcgcctcc atcgcgtact cagcgtcttg tccgtgatca acgtatttca agtgagtaga 3575341 agagaacgtt aattcgtcca cattttcagg aagcatcaat tcatcatact tctcttttgt 3575401 cagcttagga gcctcgttct gagtcttttt cacccagctg ttaaagtctt tttctgtgac 3575461 tgcattcaca tcaaactctt ggtctgcaaa atgttcacct gtgaagttcg cgttgcggcc 3575521 ttcgtaagta cccactttgt cagcctgtaa gtattgatcc atcagcattc ctgccatcgc 3575581 atatttttgc cctccaagct gaggaatcca tagcgaagcc attgaatctg cagatgagat 3575641 tttgaacaag atcgggcggt cgacaggaat gtttaagtag ttgaccgttt caatatcctg 3575701 ttcagggtag ctaaataccc atttccagtc taccgaagta gcataaacaa caagaggctc 3575761 tttgtctttt gttgcttcag gagctttttc taacgaatat atcgtctgta ctgttggcac 3575821 agaaagtgca atgacgatta aaattgggat cactgtccag actacttcta aaaacgtgtt 3575881 accgtgaatt tctgggttat aagatccatt atctttgcct ttacggtcgc ggtattttac 3575941 taaaataatg gtaaatagaa caaagacgac cccgacgata aacagcataa atccgataga 3576001 taacaggatt aaatcacttt gctgttcagc tacaggtcct ttcggatcta gtactgaagc 3576061 attgctgcat cccccaagga cgaaaaccac agttaacagc gctaatacaa gcaacggttt 3576121 taatgctctg aacaagaaga tcaccatcct tcctattgat gtaataaatc tgaagtgcat 3576181 acttcctcaa aatcttttct ctactttgtt atgctatcaa aaacttcact tattagcttt 3576241 atttttttat aaacttcatc ccattttcgc ttaaatgtca taaaatcgac aaaaattgct 3576301 ccaactttat tcacatctat cgcttaagat gaaaagtttc tagttatttc cgcatataaa 3576361 gtaaagaaag atgatgaaga actaattctg acaaattaag gtttaccaca ataaaaaact 3576421 taggtcaatc aaaaatttca ttttgttaaa ctttctagat aggaattatt ttttcctcgt 3576481 ctagcatctt ttcacacggt taccatttta acgcatcaaa tattgaaaga aaaggcgcaa 3576541 tgaagagcca atatgctctg aattgtccgt atttttttat gagagcatcc agttgtttat 3576601 cttatacaaa aaagaggaat gatataagca aataaataaa aaataggatg tgttgcatga 3576661 tgagttttct tatttcactt atcgtcgcta ttattatcgg atggcttgga agcctgtttg 3576721 taaaaggaga tatgcccgga ggaattatcg ggtctatgat cgcaggtctt ataggcgcct 3576781 ggatcggaca cgggctgctt ggaacatggg ggccgcacct agccggattt gccattattc 3576841 cagcggtaat cggcgcagcc attgttgtct ttctagtaag cctgttaacc agaaaaagag 3576901 gataaaagca gcagcacccg aagcgtcagc gctttgggtg tttgttttgc cataaaaatc 3576961 gaaaaagcct caaccctagc ggttgaggct tttgactggt ttggcgccca actgatcgat 3577021 gaaccttctg aaggcctgtt ttccctctgc tgtctgctta aatacaccgg cgtgttcaag 3577081 gatgcgcgcg aatacatgtc ccagctcttc ttttatgact agatctacgt tctcttttgt 3577141 tatggttctt ttttccatcg tccgaagagc ccactcacta tgctttgcag tgagcggatt 3577201 ttgttctaag gctgttttcg gatcagcaga acatagcgcc gctgccgttt ctttcatttc 3577261 ctcctgtaag cggccaggca atatcgccaa tcccatgacc tcaatcaggc cgatattttc 3577321 ttttttaata tggtggactt cttgatgagg atgaaatatt cctaatggat gctcctcatc 3577381 cgtccggttg ttcctcagta cgatatcgag ttcgtacaag tctcccctgc gccgcgcaat 3577441 cggtgtgacc gtattatggg gcgtatcgcc tgtataggcg gcaatgccgg ctttttcatc 3577501 ggaatacgtc tgccacgtgc ggaagatatg gtcagcagct tcggcgacat gacccggttc 3577561 gtctccttgg agcctgagca cagacatcgg ccacttcact aagcccagcg acacgccggg 3577621 ataatcattt aattcataaa cgtcttccgc ttctgcacgt gccattggaa aatcatgcgc 3577681 gccgccttgg aaatgatcat ggcttaggat gctgccgccg acaatcggca gatccgcgtt 3577741 tgaaccgata aaataatgcg gatattggcc aagaaatgac agcagccttt caaatgtttt 3577801 tttgctgatc tccatcggtt catgttcacc ttttaagaca atgcagtgct ccggataata 3577861 gacatatggc gagaattgca ggaaccattg ttcgtcctca aggatgaccg gaatgattct 3577921 gtgattttgc cgggctggat gattcacgct tccctcgaag ccgacatttt ctttacacag 3577981 caaacacatc ggataatttg tctgttcctg ctcttttgca gccgcaatcg ctttcgggtc 3578041 cttttcaggc tttgataggt taatggtcat ttccagctcg ccatattcgg tcggcaccgt 3578101 ccaatgaaca tttttggcga ttctgtcagt ccgtatataa tagacatcct ctgaatattg 3578161 atagaattcc tttgtcgcct gttttgggcc gtataatgct tttgtctctt caaatttgcg 3578221 aatgacctcg gacggggcag gcacaaaaca gcccatcagc tttgcgctga gcaggtcacg 3578281 gtacgtatct gtatccgctt ccattcggcc ggtttcggca gcccatttat agatgggagc 3578341 tagcaagtcc ggcaggcttt gtgactgctt gatgctggtg ctggagttcg gctcgggatg 3578401 tgtgatgccc agcgcttcat aaagacggtt tctcgtatat tcccgatccc agatcgaaat 3578461 caattttcgt tccaggccat actcaagcag ctgttccaga tgttcaataa tactcatatg 3578521 tcactccccc tttagttctc tcgctccctc tccgatatcc gcgacataaa agtccgctcg 3578581 gagccctgtt ttttcttgat atctgtctcc aaccttctga ataaaatcat caacgaactc 3578641 atcttttaca atgctgatgg tgcagccgcc aaagcctgct cccgtcattc ttgatccaat 3578701 tacaccttcg tgatcccatg ccgcaaacac aagctcatca agttcagggc atgttacttc 3578761 atagtcatcc ttcaatgaaa ggtgggattc cttcattaac tgcccgattt catctatatt 3578821 gttctctttg aacatatggg ccgtcttaat agcacgatga ttttcgtata cagcgtgctt 3578881 tgcccggcgt ctgttcgttt cattttggat caggctggaa tgcgcatcga aatcagaagg 3578941 cttgatgtcg cccagtgcgg caatatcgag gccttttttc agatcaagca atgcatcatt 3579001 gcattcttgg cgtctcgtat tatagctgga gtcagccaat gtcctttttt tgttcgtgtt 3579061 cgcgatgacc agcgcgaggc ctgagacatt gagtttgcta tattcatagt caagcgtgtc 3579121 acagttcagc agcatcgcat gatgtttttt ccccattcca attgcaaatt ggtccataat 3579181 tccgcaattg acgccgataa aatggttttc cgcatgctgc gccattttca caagctcaag 3579241 cgcatctact tcaggatgaa aataactttg gagcacgacc cccatcagca gttcaataga 3579301 agcggaagac gacagtcccg ccccgtttgg aatattccct gaaaatacaa tgtcaaagcc 3579361 atggggaact gcatatcccc tctgttgaaa ttcataaatc acgccttttg ggtagttcgc 3579421 ccagtcgtct tctttttgat agcgaatgtc gtcaaggctg cattccttga tgcctgcgtt 3579481 tctaaagtta tctgaataca tccggacaag cccgtcgttt ctttctgcaa cagcagcata 3579541 tgtacccatt gtcagcgcgc acggaaagac atgcccgccg ttatagtctg tatgttctcc 3579601 aatcagattc actcttccag gtgcgaaaaa aaaccgtaac ccctcttttt ctccgaatac 3579661 acttgcaaat atccccttta gctcttcccg catgtgcaat cacctttctg gtttttattt 3579721 tttattcccc ttatttcttc atagaaaacg gcagatcata tgctgcagtc ctctcatacc 3579781 ccttcttctt ttgttttttt aaagacgagc catttgctcg caacatagtt gacgacaaca 3579841 atgaccgcgt tgtcgagtat tttggccaag gtttcatttg tattgaactg gccgacaaga 3579901 atgatcatca tgcctaaatc tatgccgaga gacaggaccc gaacgctgaa aaaagcagtg 3579961 agctctttca gcaggctctg cagatcatgt gttttttgct gaaacacata taatttattt 3580021 gttatgtaag caaacagcac ggacaaaatc caagcggcaa cagtggcggc tttgtaatcc 3580081 acattcatga tctctaccaa tatataaaag ctggcgatat tcacaatggt tgtgaaaacc 3580141 cccataatga tatacataat tatttctcta tacttcactg atgttcctcg ctttctgaaa 3580201 aacttttcaa aattcttggc ctctcgtgct ctctgtctaa agtaaaaaat accgagagtg 3580261 cgtctaaaaa gctgcggaag gtggctggct ggcccaatac atatgattgt ttgatgattc 3580321 cgtcgaggac tgcacatatt attttagccg tatattcagg atcaatacag gcgtcaatca 3580381 gctttctctc cttcagccac ttaatatata acacattttc ttccacccac aattcgtaca 3580441 gccggacata ggccttgcat ttctttaaga ctttatatgt cggcatgttc atggcaaacg 3580501 aggtgatgtc ccacgacggc ttatttatgt aataggaata aagcagttct gcagcgtgtt 3580561 ttgcagcctc gtccaatgtc agcgatttca ctgactcccg ctccatttga tcaagatacc 3580621 ctataatgat cttttttttc atctgacgtt tttcgagaag gtacagcaga aaatcgtcct 3580681 tgctgacaaa atgaacataa aatgctcctt tgctgtaccc ggcggctctg ctgatatctt 3580741 ctacagaaac cggatcatac gctcggtcaa tcaacaaatt cacgccagcg tctataaaac 3580801 tttcaaatgt tgcttctctt ttaatttgaa atttgttttt tttcatattt ttctcctggc 3580861 ggtaatgatt acccttatct tacaccggat caatctttag cggtatttat ttctttaaac 3580921 ggttatgcta ttcggtttcc caggggtcat ttttaatagg ctaaatgatt tattttcatt 3580981 tacatactat ccagtcagta tttaattgtt tattattata aataaggtcc attggttata 3581041 ttagtcattt ttttagggaa taggtaggtg gtttttcctt cagtttgtga acaccgagca 3581101 actatgtgtg aaatttgttg tactcgcctc catcatcgcg ctggcttgtc ttttattgcc 3581161 cgcatgttgc aggaaaacat tttatacaat tggaggttac tatgaaaact catgttaaaa 3581221 aagatttgga caaaggttgg catatgttaa ttcaagaagc tagatccatt ggattaggca 3581281 ttcatgatgt gaggcagttt ttagaatctg agacagcatc aagaaagaaa aaccacaaaa 3581341 aaaccgtccg gcaagactag tccgaacagg cggatctatt tacctctggc ttttctatca 3581401 cctgatctga gttttcacca tatcctctat tcaaaagcaa atcgctgcgc tgagcttgag 3581461 gacaaacggt gtgtcagcta actacgacag acagccggtg atgcgatcac ctcttggcac 3581521 atgcattgtc ataaagaggt gatgcgaaca tgataaccgt gctctggtaa acagcagctt 3581581 tgctgagaac aagctgcatt cggtgaggtt ttgaaagcaa actcgtttat acacggccga 3581641 gcttgaaaac cttcgcctgt ctttagacca ctgtgttcac ctcttcacga cttccttctt 3581701 ttttcatcct ccagctattg tacaacgcat aaatcggact ttcagtacat acctattggt 3581761 gtaccttttt gcttacgttt agcgaataaa aggaggaaag ccatgtacaa agctgattat 3581821 aaacagattg ctgcaacgcc gtcttttcaa gcttttttaa agcagaaacg cgcttttatt 3581881 gttccttctg cgattttctt ttttgttttt tatttttcac tccctgtttt gacatcttat 3581941 ttcacctttt tgaatgcacc ggccattgga gctgtttcat gggcttggct gttcgccatc 3582001 gcccaattcg ctatgacctg gatactgagt actgtgtatt cccggagagc cgcccatttc 3582061 gataagtatg taagcgcttt aaaagaggat ctgaagggtg aacagacatg aatatgactg 3582121 cttttttatt atttttggcg attgttggcc tgacgcttat tatcacgtat tttgccgcga 3582181 agcggacgaa aacgacgagt gagttttata cggcgggcgg cgggctcacc ggcgttcaga 3582241 atggactggc aattgccggt gactacatgt ctgccgcctc gtttctcggg attgccggaa 3582301 tgattgcgtt atatggattt gatggcttct tttacagcat cggttttctg gtggcttatc 3582361 tcgttgtctt gtacatcgtg gcggagccgc ttcggaatct tggaaagtac acgatggcag 3582421 acatgattgc cgctcgcttt aaagaaaaga aaatccgcgg tgtcgcggct ctcaatacca 3582481 ttgccatctc tactttttat atgatcgccc agctcgtggg ggcgggcgcg ctgatcaaac 3582541 tgcttctagg gctggattat accgcggctg tcctcatcgt cggagtgctg atgaccattt 3582601 atgtcgtgtt tggcggcatg atcgcgacaa gctgggttca aattattaaa gctgttttgc 3582661 tgatggccgg cacactcgtg atttcgatta tcgtgttttc gaaattcggc tttagcctta 3582721 ataccatgtt tgaacagatg aaaacggcta ctccgcttgg cgctgatttt ttgaaccccg 3582781 gaaataaata caaggtgccg cttgagacct tgtcgttaaa cttggcactc gtgctgggaa 3582841 ccgccgggct tccgcatata ttgatccggt tttataccgt taaggatgcc aagacggccc 3582901 gtacatccgt tgtgtcagcg acatggatta tcggtgtgtt ttacattatg acggtatttc 3582961 tcggctttgg tgccgcggca tttgtcggtt ttgacgcgat tacggcggct gatcaagcgg 3583021 gaaatatggc ggctccgctt ttagcaaaag cgctcggagg agactttctg ttcgcgtttg 3583081 tatcagccat cgcctttgcc accattttgg ctgtcgtgac agggttggtg ctgtctgccg 3583141 cctcagcatt tgcccatgat atttacagcc agatcatcag aaagggagaa gcaactgaaa 3583201 aagaacaaat gaaagcggcc agatgggctt ctgtcgccgt gtcagtgctc tcgattctcc 3583261 ttgcgatttt tgcacaatcc ttaaatgtgg cgttccttgt tgcactcgcg tttgcggtag 3583321 ccgccagcgc aaaccttccg ctgattgtgt ttacagtctt ctggaaacga ttcaatgcct 3583381 caggcgcttt atggggcagc ctgacaggcc tgatcagcgc gcttgtgctg gtatcgatga 3583441 gccctagtgt gtgggacccg gccggaggtg ctatttttac cggtgatccg ctcattccgc 3583501 tatctaatcc aggaattatt tccatcccgc tcggctttct cggcgcgtgg ctcggaacgg 3583561 tgctgtcgtc tgataaaaca attgatgaag atacgtttgc agaaattcag gtgaaggcgc 3583621 atactggcgt ccatatggaa caggaataaa aaaagctctc tttatcgaga gctttttcct 3583681 tactttttct tctgctcgtc agaaatcgct ttttcaaata catccttgcc ggcagcaccc 3583741 ggaattacag tgtcaccgat aataaaggtt ggaacggctg tgatgtcagc ctcttcatag 3583801 gcgtgcttca aggcttggcg ctgcacgtcc tgatatgttc ttgtttccag tgctgatttg 3583861 aatgatgcac cgtctaatcc cacttcctcg gcgagcttcg tcaagatgtc aatatcgccg 3583921 atattttggt cctcctggaa aaatgcctga aagacacggg tgttgtattc atgtccttta 3583981 ttgtattcct tcgcaaaatg gaagccttca aacgcgaggt ctgtatacgg atggggcgag 3584041 acgtttggaa aattgatctc gactcctaat ttctccgcca ttggctgaat tgatgtctgc 3584101 cacatgtact gtttagaagg atcattgacc ggatcaagct gaggagatgg gcttgggcgc 3584161 agttcaaacg gcatccactc gacttcaaca tcctttcctt ttatcgcttc ttcaaaagcg 3584221 gcttttccaa caaaacaaaa tgggcagacg taatctgaat aaactttaat gtgtactgtc 3584281 atgataatct cctttcatac taaattgatt ttaaactgta acaattaaag ttacaactgt 3584341 tttttaataa agaagccgat ttaggcttct ttcagattga tgacaaaatc ctaaaaagtt 3584401 ttaggatttt gtcatccttt cagcgtgatt gaaaaccctt gaagtctagg aaagccgagc 3584461 attggagcgg agcgaatgct ctaattcgtg agcaccaacg cacaggcttg acaacgaatg 3584521 cgagggtttg tcgacacgct gaaagaagcc tgtaaaggct tcttttatga ttccagcaaa 3584581 cgctgggcaa tatattctcc ttttttgcag ccgcctgggc atgcgtataa agcagaaccg 3584641 attgtttgtg tatattcgtt taacgcatcc tttgctgaaa gagccttcag catcgggata 3584701 aactgattgt cgggattttt ttgaaaactg ataaacagga gacctgcatc catatagccg 3584761 gttttcggat caagtccttc tgtgtaagag aaagctcttc gcaaaatttg tttcccagta 3584821 gatttcgcta gactgacgtg tgaattagac ggaatttgat tcagcttcac gggatctgtt 3584881 tcctttttct gcccaaaagg cgcccccgag ctttttctgc ggccgaaggt atcctcttgg 3584941 tccttgaggg aagagcggtc ccatacctca aggaacattt tgattttccg aaaagccata 3585001 taggtgccgc ccgtcatcca gtcaggctca ccagactgaa tccacacgat cgagttcatc 3585061 aacgtgtcat ccttcgtgct ctggttgcct gttccatctt taaacccgaa gaggttgcgc 3585121 ggtgtttcac cattttttcc accgcttaaa aagcctttgt tcacaaaacg gacctcacaa 3585181 gtgccgaccg cttgatttag caggttacgc agcgcgtgaa acgccacttg ctcgtcgtct 3585241 gcacacactt gaatgcagat gtccccgcct ccctgctttt catccaggtt gtcattgggc 3585301 atcgctggaa gagcggctag gtgcttcggt tttttgcttt tcagtccgaa gcggtccttt 3585361 ccgtcttttt caaaaaagcc aggcccgaat ccgaatgtga ccgttaagtt ggaaggggat 3585421 aaatcagcag actcacctgt atcctgcggc ggcagatact gatttctctg ctccgctgac 3585481 attttcttgc cagacgtcag catctgtgtg agacttgtcc agtttctaaa taacgtaatg 3585541 atgtcgcttt tgtcttttgc tgttacatcc agtgcagcaa aatagacata cgtctgatgg 3585601 gcagttgtga ttccggcctg atgctttccg taaaacggaa caatctgctc ctcctctttt 3585661 tcatcctttt tcgatggctt agccgcagtc tgaacaagcg gagcgagacc gccgagaccg 3585721 ctggcaccga tcgcaacggc tgcccccgcc atcgctcccc attttaaaat gtcccgtctg 3585781 tgaatttgtt ctggcttttt ctgttcatcg ctcatgatgt tacaaaactc cttttatagc 3585841 acattcgcaa tcttcgacat ggtttcagaa agagtcgtca gcttagtgct cagctctctg 3585901 atttgctttt cacttaattt atcataagac gtataggact gatcatttgt tttgtatttt 3585961 gccattaaaa cttcaaattc gctgaactcc gtatccagtt tttccgtcaa gtcggagtga 3586021 tcttttacaa gcgcgctttt cactgtttga taaacggctt cggagccttc cacatttgcc 3586081 ataaggtcaa ctaaatcaat tcgtgagtag cgctcttctt ctcccgtgat tttcgaaatt 3586141 ccggcttcgt tcagaagctc catcgcgcct gcaacaattt gttcaggtgt taatttcagt 3586201 gattgaattg aaccgtcaag ctcttttaca tccttgagaa gctggtcagc tgttgccttt 3586261 tccccggaaa tatcttgatc cttccaaatg gccttctcaa gcttatggaa gcctgtccat 3586321 ttgtctcctt cttcaacatc gttttctcgt gcgtcaattt tcggatcaag atctccgagg 3586381 ctttcagcga tcggttcgat tcgctcgtaa taaacacgcg ctttcgcata taacgttttg 3586441 gacttttcga tatcgccgga tttcacagca cccgtaaatg cttcagtcgc tttgacaagc 3586501 tggtcactct gctctttgac atagccttta tactcatccg ctgcttttgc cagctgatcg 3586561 ctagcctttt tgccgctctt cttcgcttct gtcaggtctt ctaaggatgc tttcaatgac 3586621 tcggattctg tcttgatttt tcctgcatcc ggtttgtctt tttgcgcttc tgtgtagatt 3586681 ggctgaagat gcttttcgat ttctgtatat tcgaatggat agtcgctgcg aatatcgttt 3586741 tcaaaggaaa gccagtagct gtttaactct ttccccttct tttcaatctc tttttggtct 3586801 cctttttcca ctgagtcatt cagcttagaa atgatggttt ccattttatt tacggatgcg 3586861 gtgatttctt tagtgacccc gcttttttca gatgaagctt tttctttggt tgaagatgtg 3586921 tcattggctc cgcagcctgc gcacagcgca aggatgcatc cggctgatac agcgattttt 3586981 gtgaaattca ttttgtcagt tcctttccgt ttgtaaaatg ttttgccgct tctgaaacaa 3587041 gcgcaatcag taaaaagagt aaaatcaaca tttgcggaat cgtgctgtac acagacggat 3587101 aaattcctag caccgataca gacggcagcc agctttctgc atcagacgga agaatgcccg 3587161 ccagttgaag gctgtgaacg ccggttccga gaaatttcac gcacatatac aggacaaccg 3587221 ccattgatag aagaaaaaac ggcttcaatg gaatgcgcat tccgagcttg atcatcagaa 3587281 caccgacgat gacgagaacg ataagccctg cggcagttcc gccgatcagt tcagtgagcg 3587341 ggagcttccc gacaagcccg atgaaaaaga tgaccgtttc gagaccttct cttacaactg 3587401 ccagaaatgc aatgagcgca aaggaaagca ggcttcgttt ttttagtgcc tgtgacttct 3587461 ggatattgat tttttctctc catttatcca ttgaggcgtt tctgtgcagc cacaccccga 3587521 catacaaaag catgacagcg gacagtacgc cggtaacgcc gccaagcaag aaattgtttt 3587581 ctccgaatac actggaggag aacagaaccg tgacaccgat gccggctgct aaggaaacag 3587641 ccatgccggc ggacgccccg ccccagatcc atgtcgagga acgcgtaacc cgcgcttttt 3587701 ttgtcatggt taatagcgct ccgatgacaa ggagggcctc cattccttca cgaaccggga 3587761 tcagcgccgc atcccaccag ctgtagctgc ttgaagcgat cggctcgagc aattgaatca 3587821 tttcgtcaat ttgctttgat accttttcag gatggctgcc gatctccgcc ttcatcagcg 3587881 ccagattttc ctccgatgtc gtataggctt ctttcgattg ggacacgaca tctccctcaa 3587941 cagcgagcca ggatgtaact aaattgtcga ttgcggatga cgcttcatcc aattgttttt 3588001 tttctatgaa ctgttttgtg tctttcaagc tttgtatata ggctgttaag gacgcccttg 3588061 attgacctga ggatgtcttt ttcagcacga cagcctgctg ataggtttct aaatgagacg 3588121 caagctcttc aagctgtgtt ttgagcttac gtgcgtcttg attgataaaa gaaagagaaa 3588181 tcatcgcgat attcgcgtcc atttcactgt gagaagaaag gttttctttc ttaatagaag 3588241 gttcttcttt tttccacttc gccttgaagg tgtcaaacgt ttgttgtgcc gaatccatat 3588301 ccccgtcttt tacggatttg atcatttgct tgtttaattg aattaatgcg gcgatcggat 3588361 catcttccgc atgtgccgca gaaccgaaaa ccatcaacaa gctgaataga ataagtgcca 3588421 gcccccgagc catcatgttc ctcctataat tgaaaatgat tatcattgta taacataatc 3588481 atagccagtt cctgtccttt gtcaattaaa atttgaaggt ctgaaaacct tgatggacag 3588541 caaaaaagct gtccttttac agaacagccc tttgaaggaa aatgaacgat tatcttcctg 3588601 ttttatacgt ttgaatttcc tcacgaaact tgcgtgcagc actctcagga tcctccgcct 3588661 gactgatggc gctgatcata ctgacgccat cggcccccgc ttggataaca ggtgcggcat 3588721 tatctattgt gattccgccg atgccgacaa ttggaatgct gatgccttgg cggcgcactg 3588781 cttcgataag agatacaccc tgtaccgctc tcgtatcttt tttcgtttca gtcggataga 3588841 tcggcccaag cccgacataa tccgctccgt cttcttcggc ttgcttcacc tcagacatcg 3588901 tatgggcaga aacgccgaga atcatatcac ctatggcagc tcttacctct ttcgcatttg 3588961 cgtcttcctg gccgatgtgg ataccatcag ctttcagatt cagagccaat tccacatcat 3589021 cattgacaat gaacggaaca ccagcttcac ggcaagctgc ctgcgctttt tcagcaaatt 3589081 taatccgagc ctctcctgtc agcgcatccc cgcctttttc acggaactgg tacagggtgg 3589141 caccgccttt taacgctttt tgtacaactg taacaggatc ggctttcgta ttgtttgacc 3589201 ccataatgaa gtatacagat aataactctt tcatcatttc ccgagaaata cgagtcatga 3589261 gacagtcacc ctttctatag tcgcccattc ttggacgtct tgttcagtaa cagttgaaag 3589321 cttgttcagc aattcaatct gaaagcttcc agggcctttg tcagccgtct gctgtgcggc 3589381 aagctgagcg gcgaccccat acgaagaaat ggccgcaata gcagcaaaca atggattttc 3589441 ttccacagcg caaaacgcac cgacgacgga agtcagcagg caaccggcgc ctgtcacttt 3589501 tgtcagcagc ttgtggccgt tatgaagggt gtatacatgt gacgtgtcgg ctatgacatc 3589561 aacttcacca gttatcgcaa tgaccgtgtt tagcttttgt gccgcctgct gagccagccg 3589621 gatgatgtcg cctccacctt cacccgcatc aacacctttg atcagccaat cggtcacgcc 3589681 gacggtatgg gcaatttccg ccgcatttcc tctgattgca gcaaggcgca cctcacgaat 3589741 gatgtcacgt gccgattcag tgcggaacgg tgttgctccg gcaccgacag gatcaagaat 3589801 gacgggaacg ccatgttcat tagctgattt tcccgcgatg atcatcgctt cgactgactc 3589861 cttgctcagt gttccgatat ttaaaacgag tgcacccgca attttcgcca tatcggcgac 3589921 ctcttctttt gcgtacgcca taacgggcga tgcgccgagc gcgagcaggc cgtttgctgt 3589981 gaaattcgtt acgacattgt tggttatgct atgcaccagt gggctatgcc ggcggacagc 3590041 cgtaagacat tttgctgctg attgtgcatc catatttgca tcatccttta ctatcttttt 3590101 tcgggtccca taaatacgat ttcgtatgtt cgagccaagc tctggcggca aacgacaagt 3590161 acctgtcctt tctccaaata atggcgaggt gccaagggat gaccggatcg acaagcggaa 3590221 tgactttcac tttttccggg tcaaggccgc ggcagatccg ttccggcaaa agcccgatcc 3590281 caaggttggc ggataccatc tcactaataa aatcccattg tgatgtttca taaatgatat 3590341 ggggccggaa cccagccttg atacattccg tcataattcg gttgtgcagg acaaaatcct 3590401 ctctgaagaa aataaaaggc tcgtccttca actcacgcag ctgacattct ttctcatcag 3590461 ccagccggtg ggaagggtga acgacaagca ttaaggtttc ttttacgatt gtaaacgaat 3590521 gaaagatatc ttcgtttgcg ggaaggacca caacgccgat atcaagagag ccgtccccga 3590581 caccttcttg gacttttata gaaccgtctt cgactagctg aaaggtgaca ttcggatagt 3590641 tttcacggaa atcgccgagc actctgggga aaaaccccga tccgatcatc ggcggcagtc 3590701 caatccgtac gtgccctttc ttgacttcca taatatcatt taattctgac gtcaggtttt 3590761 gaaatgattt aatgatttcc tgcgcctgca catacatgct atgaccggca tcagtcagtt 3590821 ccacctgcct gccgtttcgg taaaacagtt caattccgag ctcttcttct aaatttttga 3590881 tcatttttga tatcgtcggc tgagaaacat aaagggattg ggaagccttc gtaaaacttt 3590941 ttaaacgggc gacttccaag aaatatgtta aatggcggat atccatgcgc ttcacccttt 3591001 ctatagacaa aaggaatact tcttattctt aatatatatt ttacctatag agagacctta 3591061 tgtacaataa gtatataagg gaggcatcaa tatgaaaaaa ctgttgctaa ccgttattca 3591121 aatcgctctg ttatttatat ttgctcggct gattaattgg gtgacagccc ttcttcatat 3591181 aaatattccc ggcagtataa tagggattgt gattcttttc acattattgc actttaacat 3591241 tatcaagctt gaatggatcg agcttggtgc agcgtggctt ctcggggagc tgcttttatt 3591301 ttttatcccg tctgccgtcg gagtgattga atacggagac attatgtcga aatttggtgt 3591361 cagcattctg cttgttgtca tcatcagcac gtttgtcgtg atggtgtcta caggaacgct 3591421 tacacaactc atcgcaaaga gaaaggagaa aaagcatacg tgttcatcgg aattgtaagt 3591481 ttgtttttaa cggttttggt gtatttagga gcaaaaaagg tatatcaacg ctttccgcgt 3591541 gtttatacgt cgccgctatt ggtgacgccc gctgtattag tcggtctgct gctgctggtg 3591601 aatgtcccgt acgagtccta taatctcggc ggcggattgc tgaccgatat gctacagccg 3591661 gccaccgtgg cattcgcgat cccgttatat aaatatttcc ctgttttaaa gaaatacgca 3591721 gtggaaatta ttttgaatgt ggccgtcggt tcatgcatcg cgattatttc taccgctctt 3591781 attgcgaaat ggcttcacct cggcaccggc ttaattgaca gcctcgtccc aagatcagtg 3591841 acaacgccga tcgcgatgaa cgtatctgaa atgatcggcg gtatgcctgc cgtcacagcc 3591901 gtgtttgtga ttttaaccgc tttgctcggc acagtgatcg gcccgatggt catccgttat 3591961 ttccgcattg ataacgaaat tgcgcggggc gtgctgcttg gcacaagcgc gcacggagcg 3592021 ggaacgtcaa aggcatttga gctcagctct gtgtccggca cgatttccag cgtgtcgatg 3592081 atcttagctg cgattatgac gctttgcgcg gcgccgtttt tgctttcatt tatgtaaaaa 3592141 actgtcctct cgagggcagt tttttttatg tgcttcccct tattgaaaag ctggcgaatt 3592201 ccaatataat gtatttgtgg ataccaaagg aggcaccctg atgcacaact tgcaggtgag 3592261 gcggcattat gccgcgttaa aaggatttta tttgtttgct tttctcggta cgggcagcat 3592321 aattccctta ctcagtatgt atttaacgaa ggaacagcat ttaagcggat cacaggtcgg 3592381 cttgatcatg tcactgggcc cgattgtgat gattttcttt cagccgtttt ggggcatgct 3592441 gagcgactat acgcaaaaaa cgaaaggcct gctggcggtt tgcacatcaa tcacaggcat 3592501 cattggatta gcctatattg catttgacag tttccctctg tttattttga ttgcggcctg 3592561 ttttgcagcc tttcaaagca cgattattcc actttcggac agcatttcac taaggtacac 3592621 acaagaaaca aacggcaact acggcggaat ccgcctgttt ggttctctcg gcttcggtgt 3592681 cgcggtgttt gccatgggac aggtgacgaa ccagctgtac cccattcacg tgatctttat 3592741 ctttggctgt gcctttctgt gcattgctgc catattggct tcacaagtgc ccggccagca 3592801 gaaaacaaca aaggtcaata tccgcaaagg attccgggag cttatcagca acaaaacttt 3592861 cctcatcttt atgatcatca cctttacgac atttgctcca aacttagcga acaatacgta 3592921 tttcagtctt tttctggaca aaagcggcgc gtcactttcc gctatcggca ttttattttt 3592981 catcggtgtc atttcagaaa ttccatttat gagattcgcc caaacattta tagataaaat 3593041 ggggctgctc aacgtcatta tgctgtcagg cggagtctca ttattcaggt gggcgctcta 3593101 tttcacggcg ccttcactat ggatcattta tgcgacggtc tttcttcagg gagtggccat 3593161 cggtttattt atcccggcgg cgcttcaata tgtgaaaaag attaccccaa gacacgttga 3593221 agcgacggcg ctgaccatgt acgccgccat tggcaacggg ttcggcaact ggttctgcac 3593281 atttgcaggc gggtacattt ttgactacgt gtcgatcttc gcagtctact tgctttttgg 3593341 cattctgagc atagcaggct ttggcctgac attatattta atgaaggctg aaaaaaacaa 3593401 acatacactt catcagccgg ctgttacttt taaaccataa tgactataat gaacaaaaga 3593461 aaggatgtgc gttatgaacg ggcaagagcg aaacagcatt tcgaaagggt tgcaggttga 3593521 tattgtattg aaagcagatc aaaaaacagg aaaactgacg agagggacag tgaaggatat 3593581 tttgacgaaa tcaaactttc atccgcatgg cattaaagtc cgtcttgaag atggccgcat 3593641 cggccgcgac cagcagatcg tttctacata aaaaaaagct gcccctgaac agggcagctt 3593701 tttcattatt ttttctgcag aaggaccact ttcaggtagt tgccttccgg aaatgccgaa 3593761 atcgttttga aatcctccgg cagcgtaaat tcctcaatga tcgtgtagcg ttcatttgtt 3593821 tctttaaagg cggcatcaat aaagcctttg aacttcttca tgccaaaggc gctgctgttt 3593881 gtagaggcaa caatgacacc cttgtcagca gtgatggcga tcgtttcctt cagcaggttt 3593941 ttataatcct tggccgcgct gaaggtgcgt ttttttgtgc gcgcaaagga aggcggatct 3594001 agaataatca gatcaaagcg caaatccttt tttgcagcat atgaaaaata gttaaaaacg 3594061 tccatcactt taatgtcgtg cgcttcgtaa tccagcttgt tcacgctgaa ttgctcgatc 3594121 gttttggcaa gacttcgatt tgccacgtcg acgcttgttg ttttctccgc tccgccaagc 3594181 gccgccgcca cggagaatgc acccgtataa gaaaacgtat ttaaaacggt tttccctttt 3594241 gcatagcggt ctctgatcgc cttgcgcaca tgtctctgat ccaaaaagat gcccgtcatg 3594301 gcgccttcat tcagatccac cgcgtattga atgccattct cttggatgat gatcgggaac 3594361 tcgccccttc tccctttcac gaagtcatca tcttcaacgt attgtccagc cgtgtcgaag 3594421 cgtttcttct cgtaaatcgc tttataatca agatccatct catccaatgc ggaaatcagc 3594481 atgtctttaa aggtgtaaat tcccttgctg taccattgaa tcagcaggta gccgtcataa 3594541 tagtcgatgg tgacgccgcc gacaccgtca ccctcaccgt tgaacaggcg gaaagctgtt 3594601 gtatcttgag cctcaaatag tttggcgcgc gcttgggccg cttttgttaa tttgctgaga 3594661 aaaaatgctt ggtcaatctg ttcatgttta ttgcgggtaa gcgtccagcc aacccctttg 3594721 ttttgcaggc cgtaatagcc ccgcgcgaga aactcgccgc cgctctcaga cacgatatca 3594781 acgaggtctc cttctttcat gtgccccgca ctccctgcga gagcttcttt ttcaataagg 3594841 ggatagcctt tttttatttt ggcagcgtgt gcttttttta gggtgagtag cttcatatat 3594901 gtcgtcctct ttccgtttgc tttctcttat ggtaccacaa aacgccaaga tgtctgcatt 3594961 gacagaaagg aaaggttttt ctacgataga caaaaagagt tacgaggagg agcagcatgg 3595021 caaaacgaat tgaccataca ggcatcatgg taagagatat taacgcgtcc atcacatttt 3595081 atgaagaggt actaggcatg aaattgaagg atcgcatcac tcacacgaac ggtgtaatcg 3595141 agcttgcttt tcttggcttt gaagacggcc cggaaacaga aattgaactg attcaaggct 3595201 acagcagcga gcttcccgct gaaggaaaag tgcaccacat tgccctgctg acggatgaca 3595261 tcgcggctga atatacaaaa gcggaaaaaa tgaacgcaaa atttatcgac gaggagatca 3595321 caacacttcc aaacggatac cgttatttct atatcgaagg ccctgacggt gagtggattg 3595381 agttctttca gcggtaaaaa taaagaacgt acattttgtg atgtacgttc ttttttatct 3595441 ataccaactg atatacgttg actcatcgca aatcatagct tcccagccca tacgctcaac 3595501 caattcatgg atgtttttat ctttggctaa aaagacatta atgaatgagt catatacact 3595561 cataaacaca aaatccattt tctcatcagt taaaacgagc tctgttgcgg cttcatcaag 3595621 aaccgtccgc aagttggctt cagttatgtc caaaacgccg cggttttcca caatcggttc 3595681 tgcgtaataa aaccgattgg atccgttcgc acctaatacc tttaccaaac tcggaatatg 3595741 aaaatttgaa atatgatcct cactgggata atagaggtct ccatttatgt tttcatgtaa 3595801 cacctcagcc aaatcctctc tcgcgaactc gtcccttaaa gcgcctatcg acgtcattaa 3595861 agccagcgcc agctcagcat gtgtttgaaa gccgcaagaa gacataacct tcttccagga 3595921 aacagccttg cctattcctc ttatttcatt atcgtttgga taaatatgtt cataatcatt 3595981 ttttcttttt gcattctccc atccttcagg catttggata aaaggagaaa agataagagc 3596041 agcagatgag tattcaactg gtacttgttg taagattggt gattcgtcat ctaaccatat 3596101 ataatctagc atgcgcacct cctttacata ttctaacatt cctttcgttt gaaagagatg 3596161 atcagcccta tgacaggctg atcatctatc acatcacatt tttatcccca gattcaaccg 3596221 cactctcttc ccgccatttt tgatgatccc atattctgaa aaacggatag tagatagcac 3596281 aggtgatcag cagatttacc agctgcataa ctgcgcccga cacctttccg cctgtcgcca 3596341 ggtaacctga tatgagcggc ggcatcgtcc atggcaccgc gattccggcc ggtcttgcca 3596401 ccagcccggt gctcatgccg atataagtcg cggtaatcgt gaggagcggt gcgatgataa 3596461 atgggacaat aaggagggga ttcatgacaa tcggcatgcc gaaaatgatc ggctcgttga 3596521 tattaaatag cgcagggccg attcctaatc gtccaagctg cttcatttgt ttgctgcggg 3596581 agcgcacaag catcgtcagg acaagcgcca gcgtcgcccc gcttccgccg acattgatcc 3596641 aaatttgaaa aaactgagtc gtaaaaatac tcggcagcgc ctcgcctgct tggaaggcga 3596701 gacggttggc atccatcgcg ccgtaccaaa tcggcgccat gattccgcca atgatggaag 3596761 ccccgtgaat cccgcacgac caaagcagca tctgcacaaa ttcagcgatc aggcttccgc 3596821 cgagactgcc gccaaggatg gaaagcggtg tgccaagcag gtctcctacg acattgtgca 3596881 gactctgaaa aggtgtcatt tcaatcagaa gacgcgccag ccatacgaga agcacaatga 3596941 taaagccggg aatcagcgcg acaaatgatt tgcttaccgc aggcggcaca ccgtctggca 3597001 ttttgaagac gatatttttt tgaataatgt accgatagat ttcggttgaa aacaaggcga 3597061 tcagcatggc gacaaataag cccttgctgc cgagcagcgt gatcgggatt ccgcccccta 3597121 ccatgatgga ctccgttgag ccatgcggtg taaacggcac ctcaaacggt gttgccagca 3597181 gaaatgcggc aattgaaatc gctccggcag aaagggcatc gacaccatag ctttctgcca 3597241 gccgataggc gatcccaaaa gcggcaatca tcgccataat atcaaacgaa gcgttaacag 3597301 gatatccgag cttatcggcc cactcgttcc caaacacact cgccatgaaa tcagcatacc 3597361 ccggaatcgg caagctcgtt aaaatcaaga agacagaccc gataataatc agcggcatgg 3597421 tcaggataat tccgtcacgc aaagcgctga gatgccgctg cccggcaatt ttcccggcga 3597481 caggcattat tttttcctcc atcacccgag tgaatgtgct catcttaaaa accccctttt 3597541 ctcattgctt tgtgaacaac ctccgcaatg ttttctttat cttattttga aaacgcttac 3597601 aaattcattt ggaaaatttc ctcttcatgc ggaaaaaatc tgcattttgc taaacaaccc 3597661 tgcccatgaa aaattttttc cttcttacta ttaatctctc tttttttctc cgatatatat 3597721 atcaaacatc atagaaaaag gagatgaatc atgaaaaaca tgtcttgcaa acttgttgta 3597781 tcagtcactc tgtttttcag ttttctcacc ataggccctc tcgctcatgc gcaaaacagc 3597841 agcgagaaag aggttattgt ggtttataaa aacaaggccg gaaaggaaac catcctggac 3597901 agtgatgctg atgttgaaca gcagtataag catcttcccg cggtagcggt cacagcagac 3597961 caggagacag taaaagaatt aaagcaggat cctgatattt tgtatgtaga aaacaacgta 3598021 tcatttaccg cagcagacag cacggatttc aaagtgctgt cagacggcac tgacacctct 3598081 gacaactttg agcaatggaa ccttgagccc attcaggtga aacaggcttg gaaggcagga 3598141 ctgacaggaa aaaatatcaa aattgccgtc attgacagcg ggatctcccc ccacgatgac 3598201 ctgtcgattg ccggcgggta ttcagctgtc agttatacct cttcttacaa agatgataac 3598261 ggccacggaa cacatgtcgc agggattatc ggagccaagc ataacggcta cggaattgac 3598321 ggcatcgcac cggaagcaca aatatacgcg gttaaagcgc ttgatcagaa cggctcgggg 3598381 gatcttcaaa gtcttctcca aggaattgac tggtcgatcg caaacaggat ggacatcgtc 3598441 aatatgagcc ttggcacgac gtcagacagc aaaatccttc atgacgccgt gaacaaagca 3598501 tatgaacaag gtgttctgct tgttgccgca agcggtaacg acggaaacgg caagccagtg 3598561 aattatccgg cggcatacag cagtgtcgtt gcggtttcag caacaaacga aaagaatcag 3598621 cttgcctcct tttcaacaac tggagatgaa gttgaatttt cagcaccggg gacaaacatc 3598681 acaagcactt acttaaacca gtattatgca acgggaagcg gaacatccca agcgacaccg 3598741 cacgccgctg ccatgtttgc cttgttaaaa cagcgtgatc ctgccgagac aaacgtccag 3598801 cttcgcgagg aaatgcggaa aaacatcgtt gatcttggta ccgcaggccg cgatcagcaa 3598861 tttggctacg gcttaatcca gtataaagca caggcaacag attcagcgta cgcggcagca 3598921 gagcaagcgg tgaaaaaagc ggaacaaaca aaagcacaaa tcgatatcaa caaagcgcga 3598981 gaactcatca gccagctgcc gaactccgac gccaaaactg ccctgcacaa aagactggat 3599041 aaagtacagt catacagaaa tgtaaaagat gcgaaagaca aagtcgcaaa ggcagaaaaa 3599101 tataaaacac agcaaaccgt tgacacagca caaactgcca tcaacaagct gccaaacgga 3599161 acagacaaaa agaaccttca aaaacgctta gaccaagtaa aacgatacat cgcgtcaaag 3599221 caagcgaaag acaaagttgc gaaagcggaa aaaagcaaaa agaaaacaga tgtggacagc 3599281 gcacaatcag caattggcaa gctgcctgca agttcagaaa aaacgtccct gcagaaacgc 3599341 cttaacaaag tgaagagcac caatttgaag acggcacagc aatccgtatc tgcggctgaa 3599401 aagaaatcaa ctgatgcaaa tgcggcaaaa gcacaatcag ccgtcaatca gcttcaagca 3599461 ggcaaggaca aaacggcatt gcaaaaacgg ttagacaaag tgaagaaaaa ggtggcggcg 3599521 gctgaagcaa aaaaagtgga aactgcaaag gcaaaagtga agaaagcgga aaaagacaaa 3599581 acaaagaaat caaagacatc cgctcagtct gcagtgaatc aattaaaagc atccaatgaa 3599641 aaaacaaagc tgcaaaaacg gctgaacgcc gtcaaaccga aaaagtaacc aaaaaccttt 3599701 aagatttgca ttccaagtct taaaggtttt tttcattcta agaacaccac acacaacctt 3599761 tttcccatcc attgtacagg cttttcatac tattgctata cagccatgaa cagcataaaa 3599821 tgaacgttat tacagttatc accacatatg gcgggattgt gactgggcag gcaggcaaga 3599881 cccaatgatg caaagggagt attaatgcct aaaaaacagg gcattttaac tcttcttttc 3599941 gtgttgggct cataacggcg ccttggacaa ccccctattc tcatgctccg tcgtcgacgc 3600001 gggcattttt gtcattttca gccggtattt ctcacttttt tcattttgat tgtcaacttt 3600061 tcatttgata cgatgaacaa gccgactttt cttcagcaaa ggaggtttta attgcttgca 3600121 taaagagatt gcaaaagaat tactgctgct cgcaggagga aaaaacaata ttatcagcat 3600181 cagccattgt acgacccgtc ttcgttttga tgtaaaggac gagacgaaaa ttgatataca 3600241 tgccattgag aacctgcaag gtgtgcaggg cacctttttc cgctatgggc ttttccagat 3600301 tatcttcgga gcaggcgtcg tcaacaaaat atataaagaa gtcgttcatg tatgggagac 3600361 cgcgccttct gaagagcctg tccaccagaa aaaagccagc cggaagctga accctgccgc 3600421 agcttttgcg aaaacactgt ccgatatttt tgtgccgatt attccggcaa taacagcaag 3600481 cggcctgctc atggggctga tcggcatgat taaggtgttt cattggttcg ctgccggcag 3600541 cccatggatt aaaatgctcg acctcgtgtc cagcacagcc tttattttac tgccgatttt 3600601 agtcggcttc agtgctgcac ggcaatttgg cagcaaccca tacctagggg cagtgattgc 3600661 agggcttttg acgcatcctg atctgctgga cccgtctatg ctcggcagca aaaccccgtc 3600721 ttctttagac atatgggggc ttcatatccc aatgatgggc tatcagggtt ccatgatacc 3600781 gattcttctt tccgtttttg tcatgagcaa aattgagaag ctattaaaat cgattgtgcc 3600841 gaagtcgctt gatgtcgtga tcattccctt tattacggtc atggtgacag ggtgcctcgc 3600901 gctgattgtg atgaatcccg ccgcgtccat catcggccag atcatgacac aatcgatcgt 3600961 ctatatttat gatcacgccg gcattgctgc cggagctctt ttcggcggca tctactccac 3601021 catcgtccta tctggattgc atcatagctt ttatgcaatt gaggcaacgc tgcttgctaa 3601081 tccgcatgtc ggtgtcaact ttttagtgcc gatatggtcg atggcgaatg tggcccaagg 3601141 cggagcgggg cttgcggtat tcctcaaaac gaaacaatca agcctgaaga aaattgcgct 3601201 ccccgcttct ctgaccgcgt ttttaggcat tgttgagccg attgtattcg gggtaaatct 3601261 caaattgatc cgtcccttta tcggagcagc catcggcggt gctattggcg gagcatacgt 3601321 ggttgcggta caagttgtgg caaattccta cggactgaca ggcattccga tgatttcaat 3601381 cgtgctgccg tttggcgccg ctaattttgt tcattatatg atcggtttct tgatcgcagc 3601441 cgtctctgct tttatagcta cattgtttct cgggtttaaa gaagagacag aataactgga 3601501 tttattcgat ttcattcata aaacggggga tgaaaggaca aaaaagctat gaaaattaaa 3601561 agaatcttaa atcataatgc tatcgtcgta aaggatcaaa atgaagagaa gattctcttg 3601621 ggtgcaggaa ttgcgtttaa caaaaagaag aatgatattg tcgatccgtc aaaaatagaa 3601681 aaaaccttta tcagaaaaga tacacctgac tataagcagt tcgaagagat tttagaaaca 3601741 ttgcctgaag accacattca gatttctgag caaattatct ctcatgccga aaaagagctg 3601801 aacatcaaaa tcaacgagcg cattcatgtc gctttttcag accatctttc ttttgcaatt 3601861 gaacgcctga gcaatgggat ggttatcaaa aatccgctgc tgaatgaaat caaagtcctt 3601921 tatccaaagg agttccagat cggcttatgg gccagagcac tgattaaaga taaactgggg 3601981 attcacattc ctgatgatga aatcggcaat atcgccatgc atatccacac agcaagaaac 3602041 aatgccggcg atatgacaca aacgcttgat attacaacaa tgatccgtga tattatcgag 3602101 attatcgaaa ttcaactgtc tattaatatc gttgaagata ccatctctta tgaaaggctc 3602161 gtgacccatc tccgctttgc cattcagcat atcaaagcag gcgaatccat ttacgagctg 3602221 gacgcagaaa tgattgacat cattaaagag aagtttaagg atgccttcct gtgtgcccta 3602281 agcatcggca cctttgtgaa gaaggaatac ggctttgagt ttcctgaaaa agaattgtgc 3602341 tacatcgcca tgcatattca gcggttctac caacggtcag tcgcacgctg agacaaacaa 3602401 aaaacgcttt tgatcatctc aaaagcgttt ttttatctga tttattggtt gatcgccgga 3602461 ttcccaatcg tattccactt cgtataggac atgtaatgga aatactcatc gcgatacgga 3602521 tgttttgtat tggagttcca aggcttttct ccgccgcaga agtgcacgat tgccgggttt 3602581 tctcttgttt cattatattg cttccgccct aacagagtcg atggggtttt cagctttaac 3602641 atgatatagg tttgagcgtt ccagcgcgga tgaagttcat accactgatc atacaagatc 3602701 gcattcagtg catcttggtc atgcagcaca agaaagtctt cgtctgggtg ttcattgata 3602761 aagttgatga ctttttctgt gatgttttgc tttctccaag actcaaaatc aataatcatg 3602821 atacctgagt taaaatactt ccctgtatca gtgacgttca tttctttcag gcgttcatgc 3602881 tgccccgcat cctcaacagc ggctacggtg tatggcgcaa tgtctaagtc ccatagctta 3602941 gaaatatcct ctaggacaag cgcatcacaa tcgatgtaaa tcattcgttt gatgctttca 3603001 tccttaatta agtcgggaat cgaaatgcgg taatacgcgg cttttgtaat atggctgctc 3603061 tcaaccgcat gttcatacat gttggtatcc acttctaaaa actcaatcgg cactccgaat 3603121 ttcaaagtgg tttcttccag tctttttttg ttatcaggct taattccgcc atcaatgacg 3603181 tataatttta cctctctctc ctgatccatg ttagtcaata aagaaacgaa catcccacct 3603241 aaatgacgag cataattatc atctgcgcat gatacgatat gcatgatttc atctttcctc 3603301 aatggtattc atctcccttt ttgttgtaca agttacatac cctttttcaa aaaaataaac 3603361 acgttctccg acattttttt aaacagaatg tgtgatacaa caaaaaaggt gtcatttttt 3603421 gaagatgcga taaagccaat aaagaatgaa aaagcttgcg attgtgatgg cttcagccga 3603481 gacgatatac cacggccatg gcccgagaac atctaagaga gaggaaccgc ccggtttttt 3603541 cgtcaaatac atataattcg cgccaagcca gcgatcaatc agaaaaatac agacgccgta 3603601 cacattaaca agcaggactg tcacccataa cgagcgctgg cccattctgt aggtgccaat 3603661 cacagccatc agcagacagg ataaaaacac agacccgtga gaaataaaaa agaggatata 3603721 tcggatatgc ggaaatgaaa acataccgag gtcaggagtg gcaagagcct gaatcgaact 3603781 gccgatgccg acaaaaaaca aaaacacaaa cagctttctg ctttttgtca ctaacataat 3603841 agctgacaaa tacaccgaca ggtcactaag ctggagaggc aatgaagtgc gcaccgacca 3603901 cctgtccgtg gcgaccatcc atatttgata gccgatttgc gaaccaagca aaagaaacac 3603961 aaacagagaa cgcaaaaacc ggctggccct cggctgcttg acctcatctt ggaacaaaaa 3604021 caacagaatg gccaaaaggg agataatcgc taacgtcact acatgctctg tcgaaaacag 3604081 atgaaacgga tcatgcttat agtcggattg aacatatttt tgcaaaactg cacccccgtt 3604141 ttcgggtttt tgtttatttt ggcgttgttt gggctttttt tattcaaccg atatatgggc 3604201 ttgaagttca caccagactc tgttaaaatt cgtttcatag ctaatgattc tgataattta 3604261 aggcaggcct aaaaaatgga acgttcacat caacatcagc agcttcggaa ggaagaacac 3604321 gatacacttt ctaagctcaa acaaatgccc gtcgagtcac tcaacctgga agccatttcg 3604381 atcgctacga atctgtatcg gtctgcacaa aggctccgtg tcaaaatgga gactgaggtt 3604441 ctttctacct ataacctttc ttggaccgct ttctccattc tttatgatct atgggtatgg 3604501 ggagcgctcg aaacgagaaa aatcgctgag ctgtcaggga tatctacagc tacagcaagc 3604561 aacgtgatca aaacgctcga aaaaaagagt ttttgccgta aaagcatcga cacaagagat 3604621 cggcgactcg tgtttgtctc aatcaccgat tccggcaaac aagcgatcga agaactctac 3604681 ccggagtttc acaaagggga aacagagctc attgcgggaa tgacgaagga cgaacagaaa 3604741 atattgacag ggctgcttag aaaggtagct gacaatcttc atacaacata agctttgacg 3604801 ggaatccagt agcggtttgt ctccctgttt cagagagccg gcggtaggtg cgagccggcg 3604861 cacaggcaaa cgtgaattac ctccccaagc tttctttgtg aaccttagta gcaaagaacg 3604921 ggaaaccgtt attcgaatga gcggaagaca atgtcttcaa ccagggtggt accgcgtgca 3604981 ttgagccacg tcccttattg ggatgggctc ttttttgtgt ttgtaaaaaa ggaggaaaaa 3605041 tgatgagaac atttgagcag ctcacagcgt cacaacaaaa agaggtagaa agacagcttc 3605101 agctatacat gacaggcgcc cacgaagtca taccgccgga ggaattaaag gcaaagctcg 3605161 tgaaatcaat ttccacgggc acgccgctta aaattaagct cggattagat ccgtctgcac 3605221 cggatgtaca tttgggccat acggttgtgt taaataagct tcgccaattt caagaaaacg 3605281 gccacattgt ccagctgtta attggggatt tcacaggaaa aattggtgat ccgaccggaa 3605341 aatcggcagc cagaaagcaa ctgactgatg aagaagttca gcacaatgcc aaaacctact 3605401 ttgagcaatt cggaaaagtg cttgatccag aaaaagtcga gcttcactat aactcaaaat 3605461 ggctgaaaac attgaatcta gaagatgtca ttgaattagc agggaaaata acggtagccc 3605521 gcctgatgga gcgcgacgac tttgaagaac gcatcgccat gcaaaaacca atctcactgc 3605581 atgaattctt ttacccattg atgcagggct atgattctgt cgttctcgaa agtgatattg 3605641 aattaggcgg aacggatcag catttcaatg tcctcatggg acggcatttc caagaacgat 3605701 acaacaaaga aaaacaagtc gtcatcctta tgccgctctt ggaaggcttg gatggcgtcg 3605761 agaaaatgtc gaagtcgaaa cacaactaca ttggcattaa cgaacatcca aacgacatgt 3605821 acggaaaaac gatgtcactg cccgacagcc tgatgaaaaa gtacatccac ttggcgacag 3605881 acttagagct tgaagagaaa aaacagctcg taaaagactt agaaaccggc gccgttcatc 3605941 cgcgtgatgc caaaatgctt ttagccagaa caatcgtccg aatgtatcac ggagagaaag 3606001 cagcagaagc tgccgaacac tcgtttaaaa cagtctttca ggaaaacagc ctgccggaag 3606061 atataccggc cgtaaactgg aaaggcgaaa aaacgatagc gatgattgat ctgctcgtca 3606121 agctaaagct cctctcttcg aagagcgagg cgcgccgcat gattcaaaac ggaggtgtac 3606181 gcatcgacgg agagaaagta acagatgttc acgccaaagc agagataaga gagaatatga 3606241 tcatccaagt cggcaaacgc aagtttttaa agctccaata atctgatatt ccgaaacgct 3606301 tatgaccctt cattcataag cgtttttttg caggtataaa gcactgtctt ttcaaaaacg 3606361 ctctccatct tgcaggaaac tcctttagca tcccgaaata ttccccaacc atacatttag 3606421 gggaggttta tttttgatga aaaagctttt gactgtcatg acgatggctg ttttaactgc 3606481 cggcacactg ctcttgccgg cacagagtgt cacccctgcc gcgcacgctg tacaaatatc 3606541 aaatagcgag cgcgagcttc cattcaaagc aaaacatgcg tactctacca tttctcagct 3606601 aagtgaagca atcggcccca gaatagccgg aactgcagct gaaaaaaaga gtgccctatt 3606661 gatcgcctca tcaatgagaa aattaaagct tgatgtgaag gttcaacgat tcaacattcc 3606721 tgaccggctt gagggtacac tgtcttcagc aggacgcgat attcttctcc aagcggcgtc 3606781 gggctcagct ccgactgagg aacaagggct gacggccccg ctttacaatg cgggattggg 3606841 ctatcaaaag gactttaccg ctgacgccaa gggcaaaatc gccttgattt ccagaggaga 3606901 cctgacttat tacgagaaag ccaaaaatgc cgaagccgcc ggagcgaaag ctgtcatcat 3606961 ttataacaac aaagaaagcc tcgtgcctat gacgccaaac ctgtcgggaa ataaagtcgg 3607021 cattccggtc gtcggcatta agaaagaaga cggcgaagca cttacccagc aaaaagaagc 3607081 caccttaaaa ctaaaagcat tcacaaacca aacctcccag aatatcatcg gaatcaaaaa 3607141 accaaagaac atcaaacatc cagacattgt gtacgtgacc gcccattacg acagtgttcc 3607201 tttttcgccc ggagcaaatg acaacggctc aggtacctct gttatgctgg agatggcgcg 3607261 tgtcttaaaa agcgttccat ctgataaaga aatccgcttt atcgctttcg gcgccgaaga 3607321 gctcggcctg ctcggctcct ctcactatgt agatcatcta tcggaaaaag agctgaaacg 3607381 aagcgaagtg aacttcaact tagatatggt aggcacaagc tgggaaaaag cgtctgagct 3607441 gtatgtcaac acattggatg gccaatctaa ctatgtttgg gaatccagcc gtacggctgc 3607501 tgaaaaaatt gggtttgaca gcctgtctct gacacaggga ggatcatctg atcatgtgcc 3607561 attccacgaa gccggcattg attccgctaa ctttatttgg ggagacccgg aaacagaaga 3607621 agttgagccg tggtatcata cccctgaaga ctcgatcgaa catatcagca aagaacgcct 3607681 ccagcaagca ggcgatcttg tgacagccgc tgtctatgag gctgtgaaaa aagagaagaa 3607741 accgaaaacc attaagaaac aaatgaaggc gaaagcatct gacatttttg aagatatcaa 3607801 ataaaaaaag acggcacttg ggtgccgtct tttttaatcc acttctttct taatccccag 3607861 cattttctca tctaggtaat gggcaatctc cgcggcttct ttcagctcat ctgttaattg 3607921 cttaggaacg tcattgttca atttataata aattttatgt tcaaggctcg cccagaaatc 3607981 catcgcgatt gtccggattt gaatttctgc tttgacgtat tccacacggt tcgttaaatt 3608041 cacaggcatc tcaatgatta aatgcaggct tcgatagcca ttcggtttgg gtgtctggat 3608101 ataatccttt acctttacga ttctcaaatc ttcatgctgc ttcaacacat tcacgacatt 3608161 ataaatgtca gaaataaagg aacagatgat gcgcacgccg gcaatgtcgt gaatatgctc 3608221 cttcatttcc ttcgtcgtaa tctcacagcc ctttctcatt aacttattca cgatgctttc 3608281 aaagcttttt acacgggatt ttgtatgttc aatcgggttg tgtccgtgaa tgaggttata 3608341 ttcctggctg ataattgaga actttgtatc gagcgcatct agcgcaaatt tataaactaa 3608401 taactcattt ttccaatctt ccattactgt ttttaaatcg tccatatgtg ttacagataa 3608461 atccatgttc gtcatctcct ttaacggaac tttatccgct gtccatgtac tagacgtccc 3608521 tgtctgctgc aaggttctat gaattttttt acaaaatgcg gtcgattgta acaaaaaaag 3608581 accgcatgaa acgagcggtc ttttttatta tcggaaatag ctgatcaata atccgatcga 3608641 gagcaggaat ccgaaaaatg tatttgtttg ggctgttgat ttcattgcga caatcatatt 3608701 catcggcatt tcgttctgga cgaagccctt cactgcctga accggcttag gcacgctcaa 3608761 aaagacgaca aacagccatg ggcttgcggc accggtaata accaagccga caacccagat 3608821 ataagcgacg gcaaacgacg cagctaacag agtaacagct cccttatgcc ccatcaaaat 3608881 cgccaatgtt ttgcgtccgc cttttttgtc ctcttcaata tcacgaatgt tgttcgacag 3608941 gttaatcgcg ccgacaagaa tcgcaatcgg gatggaaatc aaaatgctct gcatattgat 3609001 cttatctgtc tgaatgaaaa acgaaatcag cacaaacacc gaacccatgc aaatgcctga 3609061 gaataattca ccgaacggcg tgtacgcaat cggcagcggc ccgcctgtat acaggtagcc 3609121 gatcgccatg ccgacaaggc cgatcagcgc aagccaccag ctgctgctgg cacaaatata 3609181 gacaccgagc aaaatggcaa tcccgtatga ggcaagagct aattgcaaaa tcgttttagg 3609241 cttcattccg tggcgtacaa tggcccctcc gattccgact gattctgctg tatctaatcc 3609301 gcgtttaaaa tcatagtatt cattaaataa gttcgtcgcg atctggatcc ataggcaaga 3609361 aaacagcata gccaaaaaca gcagcagatc aaccttcaca taaaacatcg ccaaaacggt 3609421 tccgagcagc acaggcacaa acgatgcggt taacgtatga ggacgggtta actgccaaag 3609481 gatctgcccc atgctttctt tttgcggcgc tgtctgaccc tcacccttat ttgtttggtt 3609541 catcttcctc ttcctttcta ttaaaaggct tacttttttt cagccggcag cttaataaaa 3609601 aactcctttt gcttccttat ctatcataat gacttctccc ttatttcaca agataccgca 3609661 agaaggcgtt ttctttctta ttatacgctt ctcgccctga tttcattagg tttctgcttt 3609721 cacttgaacg aacaggtaca gaaaaatttt tttaagtaca ttacactttt taaaagttaa 3609781 aaagatcttt tgactccagg tatcttttcc tttattatga atcagctcga aacattccat 3609841 tcttgccctt gcaggtataa agattcattt tcaaaaacat acgccgatat attaatttga 3609901 gggagattag ggaaaaaatg aaactttttg agcatctgat cgtcaaataa tcatgtgatt 3609961 gtcgaaaaaa cgggaaggga atttttgata tgctgcaatt aatgaaacag ctgtatgaaa 3610021 aacccgctgt caagtggaca tgtcatacag gcttttattt gatgatactg cttgttttgt 3610081 tttttatgta tggttttcac accgcgaata ccggttcata tatttataac gatttctaat 3610141 tggagagaga ataactatga aacttttaca tgctattcaa acacatgcgg aaacttatcc 3610201 gcaaaccgat gccttccgct ctcaaggcca gtcgctcacg tatcaggaat tatgggagca 3610261 gtctgaccgc gcggctgccg cgatccaaaa acgcatttct ggggaaaaga aatctcctat 3610321 ccttgtgtac ggccacatgg agccgcacat gatcgtttcc ttcttgggaa gtgtcaaagc 3610381 gggacatcct tatattccgg ttgacctgtc tattccgtcc gaacggattg cgaaaattat 3610441 cgaaagctct ggagcagaat tgctgatcca tgcagcagga ctctcaattg atgcagtcgg 3610501 ccagcagatt cagacagttt ctgcggaaga actgctggaa aacgaaggcg gctctgtcag 3610561 ccaagatcaa tgggtcaaag aacacgaaac gttttatatc atttacactt ccgggagcac 3610621 aggaaatccg aaaggcgtgc agatttccgc tgcgaacctt caaagcttca cagactggat 3610681 ttgtgcagac tttccagtca gcggaggaaa aatattttta aaccaagcgc cgttctcatt 3610741 tgatttgtct gtcatggacc tatatccgtg ccttcaatca ggcgggactt tacattgcgt 3610801 gacaaaggat gctgtgaata agccgaaagt cttatttgaa gagctgaaga agtccgggct 3610861 gaatgtgtgg acatcaacac cttcctttgt gcaaatgtgc ctgatggatc cgggtttttc 3610921 acaggatctg ctgcctcatg cggacacatt tatgttttgc ggagaggttc ttccggtttc 3610981 tgtggccaaa gcgctgcttg agcgttttcc gaaagcgaag atttttaata cgtacggccc 3611041 gactgaagcg acagtggctg tcacatcggt tgaaattacg aatgacgtca tcagccgcag 3611101 cgaatcgctt ccagtgggct tcgccaaacc agatatgaac attttcatta tggatgaaga 3611161 gggacagccg cttcctgagg gagaaaaagg agaaatcgtc attgcagggc cgagtgtaag 3611221 ccgaggctac cttggtgagc cagagctgac ggaaaaagcg tttttctctc atgaaggcca 3611281 gtgggcatac cgaactggcg atgccggctt tattcaagac ggtcagattt tctgccaagg 3611341 acgtttggat tttcagatta aacttcacgg ctatcgaatg gagctggagg aaatcgagtt 3611401 ccatgtcaga cagtcacagt acgttcgttc tgctgtcgtg attccttatc agccaaacgg 3611461 aacagttgag tatctgatcg ctgctattgt gcctgaggag catgagttcg agaaggaatt 3611521 ccagctgaca agcgctatta aaaaagagct tgccgcttct cttccggcat atatgatccc 3611581 gagaaaattt atctatcagg atcacattca aatgacggct aacggcaaaa ttgaccgaaa 3611641 acgcattggc gaagaggttc ttgtatgacg ccttacagct cgtttttatt ctttatactg 3611701 cttggcattc ttcttctgcc gacgatcatt ctcggcttaa acggaaaaag atttcaagca 3611761 tacaacatgt tcatatctat cattatattg gctttaattt tttcgcacga cttacacggg 3611821 gtcatcgcgc tgtgcctgtt tacaatatgg caggtgctcc tgatcagcgg ctatctggca 3611881 taccggcaga aagcgaacag cggctttgtc ttttgcggag ctgttatcgc gtctattctg 3611941 cctttatttc tgtcaaaaat atggccgttt ctttcacacc cgcagccgca tcatccgccg 3612001 cataacctga tcagcttttt agggatttca tatttaacct ttaaaggcgt tcagctgatt 3612061 atggaagcaa gagacggact gctgaaagaa cagctgccat tgcaccgtct gctgtatttc 3612121 atcctgtttt tcccgacgat ttcctccggc ccgatcgaca gataccgccg gttcgtcaag 3612181 gatgaacaga aggcttggac gaaagaagaa tacgccgacc tgctgtatac gggaatccat 3612241 aaaatcttca tcggtttcct gtataaattt attatcggct acgcgatcaa tacgtacttc 3612301 atcatgaatc ttcccgcaat cacgcacaat aagattcttg ggaacctgct gtacatgtac 3612361 ggctacagca tgtatttatt ctttgatttc gccggctaca cgatgtttgc cgtcggggtc 3612421 agctacatta tgggcattaa atcaccagaa aactttaata aaccgtttat cagtaaaaat 3612481 attaaagatt tctggaatcg ctggcatatg tctctgtcat tttggttcag agattatgtg 3612541 tttatgagat tcgtattttg gatgactaag aaaaagtgga tcaaaaaccg tatggccgtc 3612601 tcaaacatcg ggtatttcct gctgtttatg ctgatggggg tttggcacgg gctcgcgccg 3612661 caatatatca tttacggcct ctatcacgcc gttctgatga cgtgttacaa ctttttcgag 3612721 aagtggaata agaaatataa atggctgccg tccaaccgct ggacaaccat tctcgctatt 3612781 gtgatcacat tccatttcgt ttgcttcggg ttttatattt tctcaggaaa accatttcat 3612841 caccaccatt aaaggagatt agaaagctat ggattttaaa caagaggtat tagacgtttt 3612901 agcagaggtt tgccaggatg acatcgtaaa ggaaaatcct gatattgaaa tttttgaaga 3612961 aggtttgctt gattcttttg gaacagtaga attgctgctt gcgattgaaa accgttttga 3613021 tattttagtg ccgatcactg aatttgaccg ggacgtttgg aatacaccta acaacattgt 3613081 aaatcagctg tctgagttga aataatgaaa aagcgttttt tcggtccaat tattttggcg 3613141 tttattctat tcgcaggcgc catcgcaatt ccatcttcat ggctgacagg cttcatcacc 3613201 gataagcgtg tgaaagagtc agcaacagcc ttgaatccga gtatgtttca agggctatat 3613261 ttacaagatc agatgctcaa agatccgaca tatcttccga tttacgggtc ttctgagctt 3613321 tctcggctgg acgagttcca cccatctaat tattttcagg taaacaatga gggattcacg 3613381 ccataccttg tcggcaaagg cggatcccag tcattgattc attctttaaa cttcgctgcc 3613441 cacatggatc agctgaaggg caaaaaaatc gtattcatcg tgtctccgca atggtttatt 3613501 aagcgcgggt ctgatgaaca gcatttcgcg ccgaactatt ctgcgctgca agggcttgat 3613561 ttggcattta acgatcagat cgatcctgaa attaaaaaga aaatgatgaa acgcatgctt 3613621 cgctttaagg ctgtgcaaaa cgatgccatt ctttctgagc tgtacaaagc aatggtaaac 3613681 ggtcagacgt ggaaagtgaa cgcgctgaag ccggcggcga aagtgtatta cagcatgctg 3613741 gaaaagaaag atctgtatta ttcaacgaca gaatcatccg ggccaaagcg ctatatctcg 3613801 cagtcagtaa aggataagtc atggtctgaa ttgaataaac tagcggatca atcgggcaaa 3613861 cgccactccg gttctaacga ttttcacatc gacaaccctg tctataaaaa gctgaagccg 3613921 aaagtgccta agctgaaagg gaaaaacaaa ggaagatcgt atgcggtgtc accggaatat 3613981 ggcgactttg aaatgatgct cgatatcctg aaggatgcgg gcgcagagcc tatgtttgtc 3614041 accattcctg ttaacgggaa atggtacgat tacacgggct tcccgaaaaa aggacgcact 3614101 gactattaca aaaaggtaaa taaacaaatc agagcgaagg gcttccaggt tgctgatttc 3614161 tcagggcatg aatatgaccc gtatttcatg aaagacacca ttcacatcgg ctggaaaggc 3614221 tgggtgtatg tcgataaagc aattgacgaa ttttataaaa ccggaaaagt cacttcatcc 3614281 tgagcatctc ataggacgcg gctgcatatt tcctgctaag atttgtaata gtaaaggaat 3614341 cacagccaac ttaattaaga ggtgttacat ccaatgaaga tgacaaataa tacggtttta 3614401 atcacagggg gttctgctgg catcgggctt gaactggcca agcgcctgct ggaacttggc 3614461 aatgaagtta tcatttgcgg acgcagcgaa gcacgtcttg cagaagcgaa gcagcagctc 3614521 ccaaacatcc atacaaagca atgtgatgtt gcagaccgtt cgcagcggga agcattgtat 3614581 gaatgggctt taaaggaata tccgaacttg aatgttctcg tcaacaacgc cggcattcaa 3614641 aaggaaattg actttaaaaa agggacagag gagctttttg tggacggtga tgaaattgaa 3614701 cttaatttcc aagcgcctgt ccatttatcc gcccttttca cacctcattt gatgaagcag 3614761 cccgaggcgg caatcgttca ggtcacatcc gggcttgcgt ttaacccgtt agctgtttat 3614821 ccggtgtact gcgcaacaaa agcggcactt cactcgttct cgcttacgct cagacaccag 3614881 ctccgcgaca cgagcgtgga agtgattgaa atggcaccgc ctatggtgga cacgggctta 3614941 aaccaaaaat cacgcgataa acaaggcctg acgtaccggg gcatttcatc tgaagaatat 3615001 gttcaatatt tcttggacgg cttgaaggaa ggcaaacagg agattacaaa tgaacgtgtt 3615061 gaaggtcttc gggatgccac tcgcgccgat tatgacaggt tattcgagca aatgaacacg 3615121 caggagaatt aatttctcct gcttttttca tatgaatttc ttacaaattt gagcaaacct 3615181 attgcgatta tttgttgaag gtatacaata gaatataatt attttcaaat aagtttgata 3615241 atataaacaa tttaacagca gggagattga ccatgactaa acaaacaatt cgcgttgaat 3615301 tgacatcaac aaaaaaaccg aaaccagacc caaatcagct ttcgttcgga agagtgttta 3615361 cagaccacat gtttgtaatg gactatgccg cagataaagg ttggtacgat ccaagaatca 3615421 ttccttatca acccttatca atggatccgg ctgcaatggt ctatcactac ggccaaaccg 3615481 tgtttgaagg gttaaaggct tacgtgtcag aggatgacca tgttctgctt ttcagaccgg 3615541 aaaaaaatat ggaacgcctg aatcaatcaa acgaccgcct ctgcatcccg caaattgatg 3615601 aagaacaggt tcttgaaggc ttaaagcagc ttgtcgcaat tgataaagac tggattccaa 3615661 atgcggaggg cacgtccctt tacatccgtc cgttcatcat cgcaaccgag cctttccttg 3615721 gtgttgcggc atctcatacg tataagctct tgatcattct ttctccggtc ggctcttatt 3615781 acaaagaagg cattaagccg gtcaaaatcg ctgttgaaag tgaatttgtc cgtgcggtaa 3615841 aaggcggaac aggaaatgcc aaaaccgcag gaaactatgc ttcaagctta aaagcgcagc 3615901 aggtagccga agagaaagga ttttctcaag tactctggct ggacggcatt gagaagaaat 3615961 acatcgaaga agtcggaagc atgaacatct tcttcaaaat caacggtgaa atcgtaacac 3616021 cgatgctgaa cgggagcatc ctggaaggca ttacgcgcaa ttcagtcatc gccttgctta 3616081 agcattgggg ccttcaagtt tcagaacgaa aaattgcgat cgatgaggtc atccaagccc 3616141 ataaagacgg catcctggaa gaagccttcg gaacaggtac agcagctgtt atttccccag 3616201 tcggcgagct gatctggcag gatgaaacac tttcgatcaa caacggtgaa acaggagaaa 3616261 tcgcaaaaaa actatatgac acgattacag gcattcaaaa aggcgctgtc gcagacgaat 3616321 tcggatggac gaccgaagtc gcagcgctga ctgaaagcaa gtaagaaaaa agccggccca 3616381 ttacaggccg gcttttttta cgcttcaatt ttgttgaaaa actgcggcag atacgctttg 3616441 tgcgcctcta gcatttcgtc taaaatctgt ttggccacag tatcggacgg gacaagcggg 3616501 ttaatcgtca tggcaaggag cgcagtttga tagtcacctg taactgccgc ttctgccgcg 3616561 acacgttcaa aggatttgat ttgctggaca aggccgcgga cagacaccgg caagtcgccg 3616621 acagcaattg gcttagggcc ggttttcgtc atcacacagt tcacttcaac tgcggaatcg 3616681 tctggaatac tcgctattgc accattattg atcgtgttca ccggctgaat gtcatgttta 3616741 tcattataaa tggagctgat taagttacat gctgcatcac tgtagtaagc tccgccccgt 3616801 ttttccagct gcggcggttt gatcgcaagg tttggatctt tataaagctc gaacagctct 3616861 ttttcgacct tctgtacgac ttcagcgcgg gtgccctccg tttgtgatgc ttccagttcg 3616921 tgctccagca tctcttttgt tttaaaatag taacggtgat agccgcaagg gatgacattg 3616981 agcgctttta agaaatccgg ttcccattcg gcgcctgaga tatttttcat cgtcatcgcg 3617041 tttttcgggt cgcccatcgc ctcgatgact tgctccttca cacttacgcc gtccaagaaa 3617101 acatccagcc cgaataccat atggttcagt ccggcaaatt ggacttctac gcggtccaca 3617161 tctacatcaa gcgctttggc tacgcccatt ttgatgccga ttggaacatt gcaaagaccg 3617221 acgactttct tcaggttgga gtagcgaagc aaggcttctg ttaccatgcc ggcagggttt 3617281 gtgaagttaa caagccaagc gttcgggcaa agctcttcta tgtcctttgc gatctcaagg 3617341 atgaccggaa ttgtgcgcaa tcctttaaac agacctcccg ggccgtttgt ttcctggcct 3617401 atcactccgt attttagcgg aatgcgctca tcctttgctc ttgcctgcaa aagtccgacg 3617461 cggaattggg tcgtgacaaa gtctgcgtct ttcagcgcct ttctccggtc gagcgtaaga 3617521 tgaatgtcaa tcgggacgcc agctttttca accatccgtt tggcgagtgt gccgacaata 3617581 ttcagctttt cttcgccctc ggggatatcg acaagccata attcacggac aggcagctca 3617641 tcataccgtt taatgaaccc ctccactagc tcgggcgtat agcttgaacc tccgccaatc 3617701 gttacaatct tcaatccttt tgtcatatgc ttgctcccct ttgctcggtg attttttcat 3617761 ataactcaat gatctctgca gccatatcct tcactgtcat tgcattcatt aaatgatcct 3617821 gtgcatgaac catcagaagc gtcatttccg tcttttctcc gcccgcttca ttttggatca 3617881 gctctgtctg ataatgatgg gcttttgaca attcttcagc agcgtcttga agctttttcc 3617941 gcgcttcttc tgcgtcaccg cttttcgcag cggcaatggc ctccattgcg gagctcctac 3618001 cgtttcctcc gtgaaggatg atttgaaaaa tgatttgttc catttcctca ttcacgcgat 3618061 tcacttcctt tctctacaga gccgcttctt tgtcatctgt tgctgcaggc gtttggacca 3618121 gctccagatc gttttcttct ttcagcttct gcttatccca cattctgaag aatggatagt 3618181 agacaacaaa ggacacggca atattaatgg cttgcatgac cgcgcctgag acttttcctc 3618241 ctgtcgccaa gtagcctgaa aagatcggcg gcatggtcca cggcactgcg atacccgccg 3618301 gtttggcgac aaggccggtg ctcattccga tgtacgtgag tgtcactgtg acaagcggcg 3618361 tgatgataaa cggaagtaag agcattgggt tcatgacgat cggcattccg aatataatcg 3618421 gttcgttaat attgaagatg gccgggccga ccgcaagctt cccgagctgc ttcatttgtt 3618481 tgcttcgggc gcgcaggaac atcgtgacaa ccagtgccaa tgtggcgccg cttccgccaa 3618541 tattgaccca gatatcgaaa aattgctggg tgaaaatctt aggaagctcc tcaccggctt 3618601 ggaatgcgat ccggttggca tccattgcgc cgtaccaaat cggtgccatg acgccgccaa 3618661 caatgtttgc accgtgaagg ccgcaggccc ataaaagcat tttgacggct tcggcgacaa 3618721 ggcttcctcc aaggcttcct cccagaatgg aaagcggagt ccccaataaa acgcttacaa 3618781 tattatgaag gctttcaaac ggtgtcgctt caacaatcag ccgggctgcc caaattagga 3618841 agatgacggc aaagccgggg attaacgcga caaatgactt gcttaccgcc ggcgggacac 3618901 cgtccggcat tttgaagact aaattgcgct ggataataag gcggtaaatc tctgtggaca 3618961 ccattgcgat aatcatggcg acaaataagc ctttgcttcc catgagcgaa agcggaatcc 3619021 cgccgccaac catgatttct ttcgtcgcgc catccggcat aaacggcact tgataaggtg 3619081 ttgctaataa aaatgccgca agggaaatgg ctccggccga caaggcatca acaccgtatt 3619141 tctcggcgag ccggtaggca atgccgaacg cggcgacaag acccataatt tcaaaggtcg 3619201 cgtcgactgg gtaggccagt ttttcagacc aggagctgcc aaacgttttt gccataaact 3619261 cagcgtatcc cgggatcggg aggttgccaa tgatgaggaa aaaggaaccg atgataatca 3619321 ggggcatcgt gaggatgata ccatcacgca gcgcctgcaa atgacgctgt cccgcaattc 3619381 ttcccgctat aggcatgacc ttttcttcta agatctgatt gactttattc acatagcccg 3619441 cccctctcta tgacacatgt ccaagctgtt cagctgattt cagcacttcc gccccattgc 3619501 acgttccata atggacggta ttaatgacgt ctaccggaac cccctttgac tctcctaatt 3619561 ttttgagctg cggaagcatg taacggactt gcggaccgag aagcaataca tccgctttat 3619621 cgatatgatt ttgtacagaa tcgcctgaaa ctgcccaaat ggtatagtct tttccctgtt 3619681 cctgcgcact tttttccatc ttgctcacca gtaagctagt agacatgcct gctgcacaaa 3619741 cgagtaatat attcatgtaa aagaccccct agagtttgat caattttgta atgtcctgct 3619801 gttgctatca tcatattatg aaatcgcttt cataaacact cagggttttt ccgcaggcaa 3619861 cggaaaaaag gtatatacag gctgtcagct cagcattttt tggtcaaaca catccgaaag 3619921 ctcttgatat gaacggcatt tgatcagctg gttcatcgcc gccgggtcat ccaaaatgct 3619981 gccaagcagt ttatacatgc tttgtaaatc cgctttgttc tccttttcga cacaaagcag 3620041 acagacaaat tgaactcgct gactctccca atcgatcggt tttttgagcg tacaaacggc 3620101 ccaaaacgtt gttttcgtct gcggaacaag cgggtgcggg atggcaacaa gattgccaaa 3620161 acacgttggc gacatgtctt ctctttcaaa aatggaatct atgatttctt catcggcaaa 3620221 gccgcattcg accactttct gccctaaaaa ttgaatcact tcttcttttg agcgcagatc 3620281 ctcctgaaaa aaaacgagtt ctttttttag gtagcgattg gctttttcct tttcatcact 3620341 cagaatagat tctatttttg taaagtcagt tccgcctaag atggtgttaa ccttcagtac 3620401 tggtacaggg agctcttttt taatcggaat ggtgctgatg acaaaatcaa ttgattcgta 3620461 ggacatttga tcaagactat aatactcagc cgttccaaga atatcgagcc gcttgccgaa 3620521 atgggaacgc agtttttcgc gcagaagctg ggcgcttccg gctcccgatg cgcatacaat 3620581 gatacagcgt ttcggcgggc tttctgtttt ttttcgttca atcgcggcgc caaagtggag 3620641 agccaaatat ccaatttcgt tttcatgaat ctcaataccc gtttgttcct ttatcacgat 3620701 tccggcaatg atcccggctt caaaagcgag tggataatgt tccttgatcg ctgccagcat 3620761 cggatttcga agattcatgc cgtatcggtt gcggctgatc gccggcttca tatgcagtgc 3620821 caagccgatt ttcagctctt tgtcatgcag gatgccaagc ttcagttcac gatcaacagc 3620881 tttgatcatg gcaagtgtca gctgatcggt ttcctcttct attgaaaatg tgtcctctcc 3620941 gcattgtgat tgtgtcattc gttttgtgcc aaggagatgc atggtgatgt aggccgtctc 3621001 gtctttcgga aacgtaacgg aaagctttga ttccagctct tttacgatgg cttctgcagc 3621061 ctggtactcc ttttgatgca ggatatgatc catatctttc gggaaaagag aaacatagtt 3621121 ttccgttctg atccgtttac aggcgatagc gatatggata atgaggttat tcagtcccat 3621181 gttggacaga gggatgcggt cgtttttcat ttttttcaag atggcggaac ggatgatctc 3621241 aatttcttct tttggcaaaa tatcagcctt ttcatttaaa acatctatct ccgtttctct 3621301 ttcatcaaca atgtactccg ccatgcagta cctcatctgc acctcgtccc cgcgcagctt 3621361 gaagccgtaa ttcggacgtg tttccatgac gatgcggtaa ggcagcagac gtttctttac 3621421 ttcctttaaa tccgtttgga gtgtagattt tgagataaat agttcttcag caagttcatc 3621481 gagcttgaga taatggtccg ccagcagcag acgtttcata agataggcca ttctctcctc 3621541 cggcaatacc ggcaggccct ttttttgctg aaattcatct tgcagcagtg ttctgaatac 3621601 ttgctcgtca tcaatgcgga gcttgtagcc ggagcctctt acagattgta caaaggcacc 3621661 gtggccgctt agcacacctt gaagttcctt tatatcattg cggactgtcc gcgtcgttac 3621721 gtttaattgc gcggcaaaaa acgaacttgt caccggggct tcagccgcca tcagcaagcg 3621781 cagaatatca cgtagtcgcc catgaagcat gagaaaaacc tcctaactag tagatgcagg 3621841 gattcagtga ataggcagaa aggatgatga agggatgcga aatgtatata aattctataa 3621901 tggagagaat ggcaagtcaa tgaacatccg gaggactaga gggaaaactg acctataaaa 3621961 aaacagccgg gatcagccgg ctgttctaga tgcggacata ttcttttgtt tagacgcctt 3622021 gcggtccttc atgatttttc gaacaatcgg gtaaatgacc ggcgcccatt tgataacggt 3622081 tttgatcatc tttttcaaag ctccgattct cccttctttt ttctcaacca ttcccctgat 3622141 tgcctcttcc ttaaacatgc taacgcgaca cgtacctgtt tcccgtcacc cagaaacgcc 3622201 atggataatc gcgtgcctcc ccgctgttgt caatgccgat gcgcgggccg gttgaaattg 3622261 cttccggtgt gtacccgctt tcgatgtaaa gcggctgttc cgtgatccag cgtccgtagt 3622321 cattcatcgt gacgccaagc gctttcgtca gctttcctgg tccgtttgtc cattccctcg 3622381 gactcctgcc cggccttctc tcctccatta acagctggcc ttcatgcggc tcaatcgccc 3622441 tgattaatac tgcttgcggg acatcctctt ccgccgcaac gacattcagc aatgtatggg 3622501 tgtgcatcac gtatgtatat acccgcccag cttctgcaaa catgatctca gtccgcttcg 3622561 tccggcggtt gttaaagctg tgggccgctc tgtctccagc ccccatatag gcctctgttt 3622621 ccacaatata gcctgacgct gtgccttcgt ctgtttcttt tacaagaagg cagcccagaa 3622681 gcgatggggc aagctcaaga gcggtttttt gataaaacgt gatgggcagc ggattttttt 3622741 ctctcgtcac gaatcgacct ctccttttac cgatttttgt acattgtacc attcccgaag 3622801 cagatcaaaa aaaacggctg ttttaaaatc tttccattca gggaatattg ttaccgttca 3622861 aaaaaggagg gccaaccatt gaaagatgat catcaaaaca agcagcacca atcaaatgcc 3622921 caagggagcg aggaagcgtt ttctcataag acatccggga aaaacgagtc agaggatacc 3622981 ttaacgaata ggcaggggca tcctgttact gacaaccaga atgtgagaac cgtcgggaat 3623041 agagggccta caacacttga gaactatgat tttctcgaaa agatcagcca cttcgaccgg 3623101 gaacgcatcc cagagcgggt tgttcatgcc aggggagcag gtgcacatgg atattttgaa 3623161 gcgtacggaa gcttcggaga cgaaccgatt tcaacataca caagggccaa gctctttcag 3623221 gaaaaaggca agaaaacacc ggcatttgtc cgtttttcaa ctgtgaatca tggaaaacac 3623281 tcgcctgaaa cattgagaga cccgcgcggt tttgctgtaa agctatatac agaagacgga 3623341 aactgggatt tggtcggaaa caacctgaaa atctttttta tccgcgaccc gctgaaattt 3623401 ccggatcttg tacacgcatt tcagcctgat ccagtgacaa acatccagga tggtgaacgt 3623461 atcttcgatt tcatttctca atctcctgaa gcgacacaca tgatcacctt cttgttttcg 3623521 ccttggggca ttccggccaa ctaccggcaa atgcagggtt caggcgtaca tgcctataaa 3623581 tgggtgaatg aggagggcaa ggccgttctc gtgaaatacc attttgaacc gaagcagggc 3623641 atccgcaacc tgacacagaa ggaagcagaa gagattcaag ggaaaaactt taaccatgcc 3623701 acacaggatc tatatgacgc gattgaaaat ggcgattatc cagagtggga agtatatgct 3623761 caaatcatga gcgatgatga gcatcctgaa ctggactttg atcctcttga tccaacaaaa 3623821 ctgtggtata aagacgattt cccatggaaa ccgatcggca aattggttct gaacaaaaat 3623881 ccggaaaact accatgcgga agtggagcaa gcttcatttg gaacgggagt gcttgtcgac 3623941 gggcttgatt tttcagacga caaattgctc caggggcgta cgtttgccta ctctgatacg 3624001 cagcgctacc gtgtaggcgc aaattacctg cagcttccga tcaactcgcc gaaaaagcat 3624061 gtcgccacca accaggaagg cgggcaaatg caatatcggg tcgatagagc agaaggacaa 3624121 aacccgcacg tcaactacga gccatccatt atgggcgggc tgaaggaagc gaagcaagac 3624181 ggaaaagacc atacgccgca tgtcgaaggt gatgtaaagc gtgaagcgat tgacagaaca 3624241 aacaacttcg gacaggctgg agaaacgtac cggagattta ctgaatttga gcggaacgaa 3624301 ttgattacga atttggtgaa tacgctttct acgtgccgaa aagaaattca ggatcaaatg 3624361 attgagaatt tcacaaaagc tgatcctgac tacggaaaac gcgtagcaga agggctaaaa 3624421 aaggtctccg aaaacaacag caacgggccg atcggcacaa ctgaaacgga acaggctgca 3624481 aagcaggctg aacaggagag tcatccgtct gatccgtatt aacaacagcg aacagggctt 3624541 ttttagaagc cctgtttttt tatttttcta ttgaaacgct ttcaataatt gtgttgtact 3624601 tggaaggaaa ggggtggaga gatacgatgg aattacagca ggacttgatt cctcagaaaa 3624661 aaacaatcgg cgctttagat cacgccgttt ttttatgcat ggtattttgt ttctggtttt 3624721 caggctatat ttacgttcct gtattcagtc tgtatttgga ggatctgcac ttttcatatg 3624781 gcgcaatcgg catcattctc ggcagctacg gggtcacgca aatccttctg cgattcccgc 3624841 tcggcctttt gtcagacatc ctgttttcct tgcgcaagca attgttaatt gccgggttcg 3624901 gcttttccgt cctcagcagc ctgctttttc tgatgtttga ttctttcttc ttcgtgctgg 3624961 ccgcccggct tttcgcggga atcactgctt ctacgtgggt gatggcgacc attttatacg 3625021 cacattattt caacaatggc aatgcatcaa aagcaatggg catcatgcag ttttttaccg 3625081 tcatgcctca gtttgccagc attgtgttct gcgggctcgc cgcagcccat ttagggaggc 3625141 aggttccttt ttggatggcg ctggcagctt ctgccgcagg tctggtgatc tgctgcttta 3625201 ttcaggatcc gtctgctcct cccgcaaacc gtggcaccat tcgtgtcaat cagtacatca 3625261 aagatacatt gcggctgcca aagctgaagc ttttcaccat cctgtctatg acggcccatg 3625321 ccgtattatt tatcacagtg tttggtttta cgccgcttta catgaatcag ctcggaatgg 3625381 gcgacgcgga gctgctttgg gtgatgagcg cctttttcct cccacacgca gccgccacat 3625441 taagctttgt gtttctgcgc tttacaagcc gtatcgctta ctccgtgatg ctcattagtt 3625501 tcgctgtcac cggggtctgt ttgctatatg ttcctttttt agctgcattg ttcacggttt 3625561 gcatcacaca cgcctgtatt gggctggcgc tcggcttcgt ttttcctctg ctgctaagcc 3625621 atgtcgtcga aatcagttct gcccgtttaa aaatgtcagt gatggggttt taccaatcat 3625681 tttatgcgct aggcatcttc ctcgggcccc ttcttgccgg aaaaatcgca cagcttatcg 3625741 ggcttgcggg agttttttat ggagccggtt ctctggcatt tgccgccttt tttgtgatgc 3625801 tcgcgcaaaa acgtaacatg atcaattaat agctttcata ccgccggaag cgccacacag 3625861 aaaacacggc cagaagcatg atgcacagaa tggagaaagt gagtgaccat ccgaaaaaat 3625921 ctgcccgctc tccatgaaga aggatatgct ccgcctgctt gcaaatctca gccggaagcc 3625981 acttcgcacc atctggaaat agtgaaacag caaaggaaac ggctgctgtg agcccgatcc 3626041 cgcaagccgc agctgctccg acagaccgga atatcgtact tccggcaagg ccggcggtca 3626101 caataaatat cacccaaaga gcgtaaaggc caaggcttgc ggcaaagcgg ctgaatgatg 3626161 cgtcctcaaa cagcagccgg acgtaatagt aagcaagccc gtatccagct gcaaacgaca 3626221 taatgccgat cacgctttgg atgagccatt tactcacgat ataatgggct gccgtcacag 3626281 gccgcgacat aatcagcgct gttacccctt gatttctttc attggctaca ctgcccatca 3626341 cgctaaagat gaccagagcc atgccaagcg tgttgaattg agaaagcgtg ctgaccatca 3626401 cttcagaccc ggagggcatc gtaaaactga ttttcatgcc gtcaggaagg ttccctccat 3626461 gtgcgatgat ttccggcata taataaatgg tcagcggctg tgtcagcccg acgatcatca 3626521 tcgcaatcgg cagccaaatc agcttgccgc ttttccatcc ttccagccac tccttctgca 3626581 atagcgccat catcaccttc atgcgtgcac cacctttaga tagacgtctt ctagagactc 3626641 cgttttctgt tcaaagcggg tgacggtcaa tccctttcgg atacagtcac ttaataatga 3626701 ccggccagcg tgtatatcag gcagctcgaa aaccgcttgg gacggattct tatagacaat 3626761 agctgagacg taaggcttct cttcaagcca accttccagc ttctctttca ctgaaagggt 3626821 aaaaacgttc gtttgctgct gttgtttcag ctcctgtaac tcgcctttcc atgaaatctc 3626881 accgtttttc ataatcacca cttgatcaca cacctgttct gcatcgtgca aaacatgtgt 3626941 agaaaacaga acggccatat gctttttcag ctcccgcatc atgtccagca cctcgaaccg 3627001 tcctgtcgga tcaagcgcag acaccggttc atccaatatc aaaaacttcg gtttatggag 3627061 cagtgcctgt gccagaccga gtctttgttt catgcctcct gaatagcccc cgatcctttt 3627121 gtgcgccgct tcgtgcaaac cgacaaattc cagcatctcg ccgattttct cttggcattt 3627181 tctcttcgaa aggccggaca gtctccccgc aaatgtcaaa aattcatttg cggtcatcca 3627241 cgaataaaaa gcaggatact gcgggaggta cccaatcaaa cgccgatcca gctttttctc 3627301 tcctaacagc tttatggttc cagaggttgg cgaaagcagt ccggccagca tttgcagagt 3627361 cgtggttttg ccggctccat taggtcctaa tagtgcgaca cactcatttt cattcacgtg 3627421 aaaactgaca ttctttacag cttcatggtg cctgtacgat ttgcataatg attcaataga 3627481 cagcatatcg gcttaccttt gctttctgcc gacggtgaaa aataaaatcg gcccgataat 3627541 attgatacat acgatgattg cagcccacat ccactttggc ccgttcgtcc gctcttcttt 3627601 tatacagctg ataagggcaa acaccgccaa agccagctgt aatacaatca gcggcaaaat 3627661 catttcccaa gaaatattca ttgcttgatc ccccttttct tccgatccgg cctaatgaca 3627721 aaaaagtaat aacaaatcag aggcatcggt gcttgaatca atccgacaat cccccaaacc 3627781 catgccatgt gattacgttt tttcgcatca ataaataaaa agattccctg cgccaatacg 3627841 atgagacaag ccgcaaccgt tatgataatt tctgtttgtg tcatccgcgt ttcacctcgc 3627901 attcgccgag atgccttttt ttctcagccg caatcaaaat cggcagcacc gcaagcacac 3627961 aaacctgaag cacaataaac acagcaggag cttgagtgaa agctaagatt gcagcactca 3628021 caaccatcag cgcgcagaat acaaataaaa tgatctcttg aagaagtttt tttctgtatt 3628081 cagctttcat ttgtgacagc tggtgaagca gttctttttg attcggtata gagggattgg 3628141 ctgtttgatc aatttttttc cattctgact ttaaatgatc agaaagcttt tctttattca 3628201 tcatcccact cctttctgat ttgctggagc cctttatgaa ctctggactt tacagtgcct 3628261 tctttgattt gaagcatcac cccgatttca gcgtaggtat agccgtagta atgccttaat 3628321 aaaaccggtg tgcgcagttt agggtccagc tttgaaaaca gatcgagcgt ttcgctccac 3628381 tctgcccctt tcgccgacac gtcccacttg atcttgcgga ttgtttcctc cgtaactgtc 3628441 tgattccgtt tccattctct ctttctcttt ttctggtgat cgagatagag ccgcgatgca 3628501 atggagatca gccatgtgga gaattttgaa cggccctgaa agcttcttaa atggatgtac 3628561 cctttcagaa aggtttcctg aacaagttcc tcgctgagat cggggtgaag ggaaagcttt 3628621 aacaagtatt tatataagaa agaatagtga tagtggaaaa gggctgtaaa cgcctcgtcg 3628681 tttccctctt tcgcctgctg gatcagccgc tgttcttctt gtgtatccaa tgaccgtgat 3628741 cccccctttt ttgtttttct gccttatgag acgacaccgg attcaaaagc gttcatcttt 3628801 tttacaattc ttttcagcca ttgacagatc aggcttcccg gccgtttggc tgcatatcct 3628861 tatttgtaaa cccccttata gtctgttaag ctatgacttt atgtcgattt caaaaaaaca 3628921 tccaatatgg aggacgatgc attgaaagta gaaaggcgaa cgattgaata tattccgaat 3628981 gaagaaagac atggtaaagc gaaagattta tttcccgtat ggttcggggc taatatgcat 3629041 atcaccacgt tagtgaccgg cacgattccc gttgcaatgg gacttaatct gttttggagt 3629101 gttgccgcta ttatttgcgg aaccttaatc ggtgccatat ttatggcttc tcattccgcg 3629161 caaggccctc agctaggcat cccgcaaatg attcaaagcc gtgcccaatt cggcgtaatc 3629221 ggagcgattc ttcccctctt cttagtcatg tttatctacc ttggtttctt cgcaagcagc 3629281 acgattctgg cggccggaac cttaagcagc tttgttccca tcccgggatc atggagcatt 3629341 ataggcttaa gtgccgtatg ttttttactc accattttcg gccatgattt gattcacaaa 3629401 atgcaaaaaa tcctttcttg gacctctttt gctgtatttt ttgctgcaac gattctcatt 3629461 tttcaattgc cgattccggc aggcagctgg atacccggag cgattgatct gccaattttc 3629521 ctagtggcag tcagcgcagt tgcgacgtgg cagcttgcct acgcgccgta tgttgccgat 3629581 tattcaagat atctgccagt taaaacaccg gcttcaaaaa cattttggta cagctatgca 3629641 ggtacatctg tcagctccat ctggatgatg ctgctcggcg cattgctgac aacctcactt 3629701 cctgacttta cggcaaactc aggcagccag attgtccaat tgttcggtcc cttctcgttt 3629761 attatgctga tcattgtgct atttgggcaa atggcaatca atgtttttaa cctgtatggg 3629821 gctttcatgt ccacgacaac aacgctggag ccgtttctga aattaaaagt cacgcccaaa 3629881 gtcagaatca tcatgatcct gggtgtcacg cttgtcggca cagtcttaag cctactggga 3629941 cagagcaatt ttatggaact gtttttgaat tttatctttt tcatcagtta tttcttaatt 3630001 ccgtggacgg caatcaattt agtcgattac tacttcgtcc gccacggaaa gtatcaagtc 3630061 aaagccatgt tcgacgtaaa cgggccttat ggaaaggtca attggatcac cacaattgcg 3630121 ttcgttctgt ctatcttgct ggaaattccg tttatcaaca caagctttta catcggaccg 3630181 cttgccaaaa tgtttggcgg cggagacatc gcatggatta tcggcttggc cgtgccttct 3630241 gtgctttact atgtattaat gaaaccgcgt ctgaaaaaac gggcggggta tcaagaaaag 3630301 ctgtcttctc tctgaagaca gcttttttat cattcaaatc gtttccacac gcggggcagg 3630361 atgtcagata gctcatgagc gagcaacgta tgagcggagt gctcgtccgt ccagagctcg 3630421 gcgcacgcac catgcaaata gaccgcgttt aatacggcgt gctttggatc ttcatggcag 3630481 cagagcatcc ccaatatcat gcccgtcagc gtgtcaccgg ttccgccctt ggcgagcgcc 3630541 ccgtttccgg ttggattgag ccagcagtct ccatcaggaa acgcgatgac ggtttggttt 3630601 ccttttaaca caatgacagt ctgcagctga gccgcccatt cctttgcata ttccgctctt 3630661 tttttctgca attcgttcac gggcacccct gtcattcgga aaaactcgcc cgggtgcggc 3630721 gtgaggatga cggggccctc ccgtttcgga tatgtgcgct tcgccagcgc tccggcatcc 3630781 aaaataacag gacaatcagc cgtaagcaca tgatcgactg cctgctgtac gctttccgtt 3630841 tgcggaaggc ccggtccgat ggcaatggcc cggtacgtct cttcaagctg agcatccgcc 3630901 gcctttttcc agccgtcacg ccaataggtc gcctcgggca aaacaggaac aattagcggg 3630961 attacgtttt ctgatgtacc gatgacaagc ttgccgagac cgctccgcat ggccccaagc 3631021 cctgcaagca gcgctgctcc cggcatgtcg tcacttccag ccagcagcaa agccgtaccg 3631081 tacgtgcctt tatggctctc cgcatctctt tcaggaagcg tggcccttac atgctcttcc 3631141 gtccaaaatg gaacattcat ctctatccct cctctgcttt cttttcctat ttttcctgtc 3631201 ccttttcttt ttcaaacaaa aaagacagcc ttttagggct gtcttttatt ttacaggaac 3631261 atcaaggtga tacaggcggc gatatcgttc gtttgccgcc agcagctcct catgggttcc 3631321 ttccatttct gttttgccgt tttcgagaaa tacgatttta tcggctgctt ccactcccgc 3631381 gagatggtgt gtaatccata aaatcgtttt tcctttcagc acctcaaaca ccgtttccat 3631441 caattcacgt tcggtaatag gatcgaggcc gactgttggc tcatcgagga tgatgatcgg 3631501 tgtatcctgc agcaaaatcc tcgcaagtgc gatccgctgg cgctctccac cggaaaaacg 3631561 gatgccggtt tcttgtacag aggtatgata tccgtcaggc aatgactcaa tgtagtcatg 3631621 cagcttgacc tgctttgcgg cgcggcgcac atcctcgtcg cttgcttctc cgtttccgag 3631681 cctgatgttg ttcaaaatgc ttgtatcaaa caggtgcggt ttttgattta acacggccac 3631741 cgcatccgca atctgatcct ttaacagcgc tgtctccact ccgtttaacg tcacagaacc 3631801 ggagtccggt ttcaaggcgc cttcgattaa tgcaagcgat gttgatttcc cagagccgct 3631861 tcggccgagc agcgccattt tttctccttg gcgcagcgta aaggaaaagt tgtgcagcac 3631921 ttggctgctg ttgtcataag aaaacgtcac atcacgaaag gccaaggtga catcttgaag 3631981 atcgagaatt tgatcccctg attcagtttg tgacgcctcc ggctgaggag ccacattgtt 3632041 catgcgtctg atagaatcct gatagcccgg cacttcgcct aaggcatccg aaagcggcaa 3632101 aaaggcttcc gtcaacggaa acaccactag cacaaaagcg gcaatcatcg ttttagcgag 3632161 ctcgccgtcc gcttgctgtc ccgctgtcca aaacagcatc agcaaaataa ggccagcgac 3632221 aaggcattgc gcagcaaagt cccgccatct tgtaaagcgt tgttttttcc gttcaagctc 3632281 aaaccaatca cgttcctctt tttcataagc atcaataaaa gcatgccggc gtccgctgaa 3632341 catccagtcg ctgacaccca tcacagcatc tgtcagacgg ctgtacagca cattccgtcc 3632401 gcttttcagc ttcgcattct tcgctctcgt cacgagcaaa gacacaaccg gaaacaatac 3632461 aacaagaaca aacaaataca gcgcaagcaa tatggcaaac ggccaagaga agaagccgag 3632521 cgctatcact gacacagcat acaggagcaa ggctgagatc gcaggaaaaa tcgtttttaa 3632581 gaaagcatcc tgcaaatgct caatatcctc agacaaaatg ccgagcatat cccccgtgcg 3632641 aaaacgggaa cgcagcatca aagcacccgg ctcaagcata ttgtaaaggc ggacgcgcat 3632701 gtcagatacg attttcaaaa tgatgtgatg gccgacgagc cgttccacat atcgcgacac 3632761 agagcgcgca atcccaaagg tgcgcacagc gacaatcggc acataaatga gcagaatgtt 3632821 ttccggcctt gtcgccgctt tagaaatcaa aaaacctgag gtgaacatga gaaaagcagc 3632881 agaaaaaatc gtcaccgcac ccaaaaagat aaccagaacg aacaggcggg cattttgctt 3632941 gatatacggc aaaatccatt cttctttctt catgctcttt cccccagttg tgccttcacg 3633001 agtttggtat acacaccgtt tttctccagc agttcattgt gagtcccaat ttccgcaacc 3633061 ctgcccccgt caagcacgat aatttcgtcc atatcgagca tccagtgaag gcggtgagtc 3633121 gcgagaaaga cgagcttatc ctcaaataaa tccagcatcg tttcttttat ttcatattct 3633181 gtttcgatat caagatgggc ggtcggctca tccagcagca ggatcggacg gtttcccaaa 3633241 aaggcgcggg ccagcgcgac acgctgtgcc tggccgccgc tgagcgcccg gccgccttcc 3633301 ccgatccgcc cctctaatcc gtcaggaagg ttgttcacca gctccgtcag tcccgctgag 3633361 gcagcagcac gtgttgtatc ctctgccgaa gcgcttggat ggtagaagcg aatgttgttg 3633421 ccaagcgtat catcaaaaat gtacggatgc tggggaatgt aaagaaggtt cttctgccag 3633481 ctgccgtcct gcaaatggga ccggcttgta ccattaacct caatcatccc gccatccggc 3633541 tctaaaaatc cgccgagaat atcaattaat gttgattttc cggcgccgct tgcaccgata 3633601 atgccgattt ttttcttgcc tttgaatgag agatgaatat cagacaccga acggccgact 3633661 gacacgcctg acagcttcag ctcatcctga tcggaccaag cttcgagctg aagcggcgtc 3633721 tcttctttaa aaccaggctg cgacaaaatc tcttgaatgg tttttcctgc ttcctggccg 3633781 ttcagcgttg catgataatc attccccact tcccgcaccg gcaaaaaata ctcaggcgcc 3633841 agaataagcg ccgttaaagc agggccaagc aaaatatcgc cgtcaatgag gcgcaggccc 3633901 agaaatactg cgactgtcgc caccgacagc atcgtgaaaa aatcgagggc gaatgatgac 3633961 aaaaacgcca cccggagtgt gctcatcgtt gccttgcgat accgctcact cacatagaaa 3634021 atatttttgc tgtgtgactt gctcaaacct aggaaacgca atgtctccag cccgcgaaga 3634081 gaatcaacaa aatgattgga aagtctctga taggatttcc actgacgatc cgcttttctc 3634141 tgcgcgacaa ggccgaggag aatcataaag atgatcagaa tcggcatagc agcgactaaa 3634201 atgatggctg atgtccgatc ctgaaaaaac acataaatga caactgccgc aggcacaatc 3634261 gccatgctga ccattttcgg cagaaacagc tccaggtagc ggcggaactg gctgatgcct 3634321 tccatcgcca gcgtcaccat ttgccccgtc ccctctttct ttgcaaagcg ggggcctaat 3634381 cggaacagct gatcaagaaa acttttcctc aaatctgctc ctgtccgggc ggcgtattga 3634441 tagacgattt tctgtcgcgc caccgtcatc ccgtgccggg cgataaaagc gatgaggaaa 3634501 aagccgatca ccggtaaaag ggaggtaatg cccttcccgt tgaacagtcc ggttacggcc 3634561 tcactcagcc actctgcctg cataataatg gcggctgtct gaatcaacgt taaacaagta 3634621 atcaaggtga gaatccgctt cattccttta tatcgaaaca ggtcttttcc cattaataag 3634681 tcataggctc cttatggctg acgcgcttcc ggaagacata atagctccag atctggctgc 3634741 cgatgacgaa cggcaatagc gttaatgctg caattgacat gactttaagc gaataatctc 3634801 cagaagaagc gttagctact gttaaatcgt atgcgctatg aagcgagctg accattacac 3634861 gagggaatag ggaaataaag atcattccca cggtcagcgc cagaccagcg cctgtcatcc 3634921 caaatgtcca gccgtctttt ttcttacgaa taaatacagc cgcgagcata aagcagatga 3634981 caatcaaaac agcgagcgga atggtaatct cgccgcggcg tgtaaacatg tctgtctgat 3635041 acgcagaaag ggccgcgaag gcaagaaccg ctacaaaaac aacacccatt atcttttgcg 3635101 ccattttccg ggcgcggttt tgcaaatcac caatcgtacg cagcgtgata aacattaatc 3635161 catgctggaa gcaaagaagc gttaccgtca caccgccaag tatagaatat acattgatat 3635221 aatcagatac atgtgcgtga atgttcatgt cggcatcaat cggcatcccg cggaataatg 3635281 tcgtgaacag cacaccaagc acaaacggag gaattagact gccgaaaaaa acgacccagt 3635341 cccaaacctt tacccatttt aaatgatcca ccttgccgcg gaactcaaac gcgaccccgc 3635401 ggcccattaa cgcaagcagc actatgacaa acggaatgta ataaccgctc agcatcgttg 3635461 cataccagtt tgggaatgcc gcgaaaatgg cgcctgcgcc agtcaaaagc cacacttcat 3635521 tcgcgtccca gaacggcccg atcgtgttga tcagcactct gcgttctaat tcattatggc 3635581 caagaaaacg ggtcgccatg ccgaccccga aatcaaagcc ttccaaaaag aagaatccta 3635641 caaacaatac agcaacgagt ataaaccaaa gatcatgaag agatgccatg gtatacctcc 3635701 tgactaaatg gatctgttga tacaggcaca tcatgatgat tatcatgctc cgcacctttt 3635761 ttaatctcac ggataaacaa gaagacaagc agtgcaccaa gaatcatgta catcacaccg 3635821 aatgcgatga ttgagaataa caaggaaccc gctgttacgt taggcgacac agattgagcg 3635881 gttgtcatta accccataac cgtccaaggc tgacgtccga tttctgtcat aatccagccc 3635941 gcggagtttg caagaaacgg gaaggaaatc aacgcgatca tgatgcgcaa ataccatttg 3636001 ctgttttcaa gctttttacg gcggtttaac caaaggccgc ctaacgcagc aagaatcatg 3636061 acaacacctg ctcctaccat gatgcggaag ctccagaatg tcgttttcac tggcggaatg 3636121 tagtcgcctt ttccgtatat tttttcgtac tcagcctgaa gggttttcat ccctttgaca 3636181 cttccgctga atttctgata agccaagtag ctcaaggcat aaggaacttt gatttcattt 3636241 gagctttttt cattttttgt atcgatcgtc gcaaaagcgg tccaagcagc agggtcaccg 3636301 ctgtcttccc ataggccttc actggcagcc attttcatcg gctgtgattc catcaagtgc 3636361 tcagcctgca tgtgtccgct aaggccgacg ccaagaccgg cacaaagacc gacgatcatt 3636421 gcgagtttaa aagattgctt aaagaacggc acttcttttt tcttcagcag tttaaaagca 3636481 ctcactccgg caataaagaa agctccagtg gcaagcgcac cgaaaataac gtgcgggaat 3636541 tcaacccaaa gctgagggtt tgtaatcaac gcgccaaaat cattcatttc cgcgcggccg 3636601 tttttgatcg taaagccgac cggctcctgc ataaaggagt ttgctgttaa aatccagaaa 3636661 gatgacatga tcgttccgaa tgatacgagc catatgcaga gcgcgtgaat tttcttcggc 3636721 aggcggtccc agccaaaaat ccataatccg ataaaaatag attccatgaa aaacgccaat 3636781 aatgcttcaa tcgcaagcgg agcgccaaat acatctccga caaaacggga gtaatctgac 3636841 cagttcagtc caaactggaa ttcttgcaaa atccccgtta caacaccgac tgcgaaattt 3636901 attaagaata agtgtcccca aaactttgcc attttgagat acagctcatt tttctttaca 3636961 agataaagag tctccatcaa cgcaaccata aacacaagcc cgatagacat cggcacaaac 3637021 aagaagtgaa acaacgttgt tgatgcaaat tgtatgcggg ctaataccaa ttcactcatg 3637081 ctttctcctc catttccggt taaaactgtt aatttgctca ctacttcaca aatagaaccg 3637141 agactttgat cagtaattca caaaatagac gaaaaaaata ttgctcaata tttcacaaat 3637201 gtgtcaaaaa gtcatccaat atgatgcaag attgccagac tgaccaaatg acacaatctc 3637261 tgactggttc atattaagta ctttacaacg attcatttca aaaataaagc ctaaaatacc 3637321 taaaaagtcc cgcactatgt gacggatttt tgtctatttt gttgcttatt tatgtcggct 3637381 gctaggataa atgacccttt attatcgtac atcaacacat cgttccttgc gaacaaaatg 3637441 cttgcccccg ccccagcact cgagtctcag cattccgtct taaaccgatt ttagtcagaa 3637501 tgcctctttt catttgaacc ggtaagagga gaaaagttga atagtaaatt tttaatatat 3637561 taataatttc aattttttag tatacttaac atagtgaaca atttcactgc atcaagaata 3637621 ggggaggttt ttcaatggga gagcttcaaa cacacatgca attgcaaacg gatacaattc 3637681 acgaaggggt tcgaaaagag aattggtttg cgaaagccat gaatataaaa gtaggcatca 3637741 taccgcttcc tgtgtatgcc ttgctgttta tattaatcac tgtttttgtt atgcatcacg 3637801 atgtaaaaag tgacattttg acatccattg ccgtcatggc gtttttcggg tttacctttg 3637861 cccaaatcgg caaatcgata ccgattgttc gttctatcgg cggcccggcc atcctagcta 3637921 cttttattcc gtccgctgtc gtgtactatc acctgctgcc taatgatatc gtcaaatcca 3637981 ccacagaatt tacagaaaac tcaaactttc tatatttgtt tatcgccggt attgtcgtcg 3638041 gaagcattct cggcatgaaa agagaaacac tcgtaaaagc attcatgaaa atctttattc 3638101 cgcttattgt cggttctgtc acagccgcta ttgtcggact ggctgtcggg acattgctcg 3638161 gactcggatt tcagcatacc ctgctgtaca ttgtcattcc gatcatggct ggaggagtcg 3638221 gagaaggcgc tatcccgctg tccatcggat attctgacat catgcccatt tctcaagggg 3638281 aagcgtttgc acttgttctg ccatcgatta tgctgggcag cttgtgcgcg attattctag 3638341 cgggattgct gaaccgaatc ggaaagaaaa aaccggaatg gacaggcaac ggcaaagtgg 3638401 accgctccga agaagagtcc cctgcgctgg aggaatctca aagcggacag caaatgttca 3638461 acctttcttt atttgcgtca ggcggtatcc ttgctgtttc tttatactta gtcggcatgc 3638521 tcgctcacga ttttttcggt tttccggcac ccgttgccat gctgttactg gctgttctaa 3638581 tcaagctgtt cagattggtg cctgcctcaa ttgaaaatgg cgcgtttgga gtgtcccgct 3638641 tcttttcaac agctgtgacc tacccgcttc tctttgcgat tggggtatcc atgacgccgt 3638701 gggacaagct tgtcgccgct tttaacctca gcaatattat cacgattctg tctgtcgttg 3638761 tgaccatgat ggccgttggc ttcttcactg gaaaatggct gaacatgtat ccgattgaaa 3638821 ccgccattat taatgcatgc cattctgggc aaggcggcac gggtgacgtt gccattttaa 3638881 gcgccgctga aaggcttgag ctaatgcctt tcgcccaggt gtctacccgc atcgggggcg 3638941 cgattacagt atccttaacc ttattgctgc tgcaccagtt ttattgatcc ccgcaagcaa 3639001 gttcttcgtc aaacgaaaga gcttgctttt ttgcatgtcc atgtttttgc aagttcccat 3639061 cccatgctat agtaatagtt ggaaatacta gatagaaagg aatctggcat gcctatggga 3639121 actcatctat ttctctttat gcttctcggg ctgggatttt atttgatatc agccctagct 3639181 gcaaaactca ttccggccat agacttctgg attgatattg ttctatgggt cggcgctgcg 3639241 gcttacatct tctctcatct ctcattcatg gacggcattg tctcactcgc gacaatgttc 3639301 tactgctatt ggaccgcaat ggatctcatt gtttcagagc gtgtggaaaa accttcggga 3639361 gactggcagg aaatcgagct tgccaaaaac aaaacacgcc tcctgtcaga cattacgctg 3639421 accgccattg tgtttgcagg ggctgtcatt tttttcatct atggacctga cacaagccct 3639481 ctcaaatatg tgatccttct cggaatgatc tccggcggag gggcacttgt gaagcgaata 3639541 ctgaatgttt ttagcgtaaa ggttttttat tcagcagcct tagaaaaatt gcatatcagc 3639601 tcacactatg aaacccgtac atacccgctt tccgatttga agaacattca gcttgaatca 3639661 acagcagatc tcttaaagct ccatccgctt ctgacgatgt attcatcccg tttagatttg 3639721 acaacaagct ttcagcaagt cattaaactg tctcttcccg gcgaaacact gtttctgacg 3639781 gtgaaggaac cgcaaaaatg gaaaacaatt cttcaggaat acacagatgc agaaaacaat 3639841 gtggacaatg tgatttctgt tttgccgttt tatcatcgaa aaaatgtgaa gcggctgctc 3639901 ggtaagcttt attttgccgc cagcgtaaaa ggggtatccg cttacgcctt attggtgctc 3639961 gcgttatacg cattacacgc ctctccatgg gtcatggctg ttgccgtaat cctatattgg 3640021 gtattcaaca tgtatatgtc agaccgtgtg ttgcgggcgg cgatggacgc caagtcttgt 3640081 catcatccgc atgtacaggc cgcggccgat aagattttca gatcggccgg catttcccat 3640141 gtccgcatat acgaaacgga gagtgatgat tacaacggaa tggcagtagg catgaatgtc 3640201 gggaggtcaa tggtcatcct gacaagcgcc acactaacac ttccacagcg tgtcattgaa 3640261 ggcattctgg cccatgaggc gattcatatc aaaaaacgtg acgttctgtc atcacagctt 3640321 ttgcgttttc tatatcttgg agctgtcgtg gggattttcc tcttgtttga gcagcatatc 3640381 acccatcccg aggcccacaa aattgcgctt tgggctttca ttatggcaat cattatccta 3640441 ttccagctct atcaatcctt ttgttcacaa tggatggagg tgcgtgctga caaccttggc 3640501 gcatcattgc tggacggcgg ttacaaacaa atggctgaag ccttgagaat cttggcggtt 3640561 cggcaagatg aggatataca gaaacaaagt gcctatagct ctgaagcagg tgaagacgag 3640621 cttcaaattg attctctcac ccgtgataaa agctggtttt tcagattgat tgattttcag 3640681 ttcgctcctc atcctcctat gtattggcgt gtcggcactt tattgtcaaa caaaggacat 3640741 ggggtgctaa agcgctggct cagagaccga ctgaaagaat cgatcacttt gaaatgaaac 3640801 cggtcagcgt ttcatccgta taacagatat ggtgaaaaaa gggagtgacg cgaagtgatt 3640861 gtgatcatct tattgtttat atctattatt gtttttcttt cagtcattca gccgcagccc 3640921 tcgaaaaaca aaagccgcca gcaggcggac agcgggtatt tcggttattc agatcatagc 3640981 tcacaccatg atggatgcag cagtgacgga ggtttcagcg attccggctg tggcggcgga 3641041 gggggcggcg attaaacgcc gccttttttt atttcattga ttcgatgtac gcaccaaaag 3641101 ccgagcctga catgcctggg gacacgcgca cacgatggag ggcatacatt ccctggtctc 3641161 tcgaagccgc gcccggttct gtcgtcacgc ccatttgata gcctgttttt tcagcggcct 3641221 tcagcgtctc ctcattgtag cgccctaccg gatagctgat gatggtggtt tgctgatgaa 3641281 acatgttgtc gaacagcttt ttcgaatcag ccatctcact ttgctgctgt tgaggcgtta 3641341 atccgttcag ctcaaggtgg tcaatcgtat ggctttcaat cgatatgccg tgctgtgcca 3641401 tttccttcat ttgttcctct gtcagatggt gcttatgtcc gatcgatttg ccgatcataa 3641461 aaatcgttgc cttcatcccg tactttttca gcaccggata cgcatcttga taattgtcgg 3641521 tgtacccgtc atcaaatgtg atcagcacgc acttctcact cggtttttta tcctgcgtca 3641581 gcatgagaga tgcctctttc ggcgttaatg tctgatagcc gttatcatga agccacttca 3641641 tatgcgcctc gaattctttc tttggcacac ggaggctgtt tcctgaagaa atgctgtggt 3641701 acatcaaaat cggcagcttt gccggtttct ctgttttgat ccatgcggat gtatcgtctt 3641761 cttttttctg aacttgtact gccttttttt ccggtttctt ttgttccgct tttggcatcg 3641821 gctgctctgc attcgcctct tgatcagcac aagccgcaag agccaaacag ctgcccaaaa 3641881 gaaagatgct taaaaacaat cgtttcatcg ttctcctgct ttctgtctat ttcttcctcc 3641941 tttttcatcg gtttgattct gagattttca atagcaaaaa accggacatg tctccatgtc 3642001 cggttttttt gatcttatcg gattctcact tctgtctcac tgtcaaagaa atggccttta 3642061 ttcatatcaa atgcaaccgt cagctcatcg cccgattgaa tatcgaggcg ggcgtcgatc 3642121 cgcgcaataa agtcttggtt gtctatctgc gaataaatca taatttcaga accgagcagc 3642181 tctgcaacat taattttcgc cttaatcgaa gagttcttat atgattccac gacaatcaat 3642241 tcatcatgta tatcctcagg acggatgccg aagatgacct ctttgccgat gtagcctttt 3642301 tcacgcagca ctttcatttt tccttccggg acggttaatg ccgcagaacc gattttgatt 3642361 aagccatccg tgagctttcc tttgaaaaaa ttcatcgccg gtgatccgat aaacccgccg 3642421 acaaagacgt tttcagggaa ttcatataca tccttcggcg tcccgatctg ctgaattttc 3642481 ccatctttca tgactacaat ccgtgtcgcc attgtcagcg cttctgtctg gtcatgcgtc 3642541 acataaatcg ttgtagtctg caatctctgg tggagcttaa tgatttccgc ccgcatttgc 3642601 accctcagct tcgcgtccag gtttgacaaa ggctcatcca tcaggaacac ctttgcatcc 3642661 cgcacgattg cccggcccag cgcaacccgc tgtctctgtc cgcctgacag cgctttcggt 3642721 ttacggtgca aatattcctc aagcccgaga attttagcgg cttcttcgac tctttttttg 3642781 atttcaggct tcggcatttt ccgaagcttg agcccgaacg cgatattatc gtagaccgtc 3642841 atatgcggat aaagcgcgta gttctgaaat accatcgcga tatccctgtc ctttggcgct 3642901 acatcattga cccgttttcc ttcaatataa aaatcacctt tcgaaatttc ttcaagtcct 3642961 gcgaccattc gcagcgtcgt tgatttcccg cagccggacg ggccgacgaa tacgataaat 3643021 tccttatcgg caatatgaag gttaaagtca tcaaccgccg gttccttctg atcataaaat 3643081 ttataaatgt gctccatccg caattcagcc atctaacatc cccctttgtt attgtaaacg 3643141 ctttcttata ttgagtgtaa cagcaattcc ctctcgctaa aatgggcagc gttcataaaa 3643201 tcacccagcc atttttcgtg catatttcca atttattctg aactttcatt ttgcaggcag 3643261 ataaaatagg caagaagcgc gcctttgtac gatttgatat ctatccctga ccgctcaata 3643321 aatttatcaa tccgatattg caggctgttg cgatgcagat gcagcttttt cgctgttaat 3643381 gtgacgtttg agttgttttc aataaacagc ttaatggtct tccttagctc agattcactt 3643441 ccaaataaaa gctcagcttc ttcagagagc agtgtttcca gtttttcttt ttctgtttct 3643501 aataatagaa aaggaaagat catctcaaag gtcacactct gcacctgagg cagccgtttt 3643561 tcagcaaaca ggaaatacgc ctgttcacga gcgtaatgtt ttcgcagaca ctcatccggc 3643621 tcgtaaaatc ttccggcgta aaaacggaca ctgaagtaga aatcactttc aagaacctta 3643681 gcgagcgatt ccagttcgtc cttctccgcc gccgcttcac tttcctgctc gacaatcaca 3643741 cctctgtcct catggatcca cacaatcaca aaagacaccg gccaaaaatg gcgaaccgct 3643801 tccgtaaagg acgtcctttc tattttgccg aataaatgaa agtgaacaaa tctcgtccgt 3643861 ttctttatat acgccggcaa ttcccctctg gaaaaaagga acgaaaacca cttgttttcc 3643921 tcaggtgatt tcatagacag ttgattgccc tcatccgcag gcgtcaaaaa tgactgcagc 3643981 accaatactt ctttttcact gatctctgtt ttcggaatgg agatatatct ctgattgctc 3644041 tcatcaaaaa aacatagaca gccttccctt atgcaaagct cctcagacac aatcgaaccg 3644101 ggataaatag ccagcagcga tttcatagag tctcctctct tatgtaagga tctgtatatt 3644161 cagtataagg cgaaacacac atgttctcca ctaaaaaaga gtatatccgg tatagataga 3644221 cgagaaactg aaagggaaac ctcattcgtt tacatattgg cttcagcgga aatagaagaa 3644281 gacatgcagg accaaaggag ggtcatctta tgagtttcga aacgttaaac aaaagtttta 3644341 tcaacggaaa atggactggg ggagaaagcg gacgtacgga ggacattttg aatccgtatg 3644401 accagtctgt gatcacaaca gcatctttgg caacgggcaa acagcttgag gatgcgtttg 3644461 acattgcaca gaaagcccaa aaagagtggg ccaagagcac gacggaagac cgaaaagccg 3644521 tgctgcaaaa agcgcgcggc tatttacacg aaaaccgtga tgacatcatt atgatgatcg 3644581 cccgcgaaac tggcggaacg atcattaaat caacaatcga gctggaacaa acgattgcga 3644641 ttttagatga agccatgacg tatactggtg aattaggcgg cgtcaaagag gtgccatccg 3644701 acattgaagg gaaaaccaat aagatttacc gccttccgct aggtgtcatt tcatcgattt 3644761 ctccatttaa tttcccaatg aatctatcca tgagatccat tgcgcccgca attgcgctgg 3644821 gtaacagcgt tgttcacaag cctgatatcc aaactgctat ttccggcggg accatcattg 3644881 cgaaagcgtt tgaacacgcc ggtcttcctg ccggtgtcct taacgtcatg ctgacggatg 3644941 taaaggaaat cggggacggc atgctcacca atccaatccc gagattaatc agctttacag 3645001 ggtcaacagc agtcgggcgc cacatcggtg aaatcgccgg tcgcgccttc aaacgaatgg 3645061 cacttgagct cggcggcaac aatccatttg ccgttctttc agatgcggat gtcgatcgtg 3645121 ctgtggatgc cgcgattttc ggaaaattta ttcaccaggg acaaatctgt atgattatca 3645181 acaggatcat cgttcatcaa gatgtatacg atgagtttgt agaaaaattc accgcccgtg 3645241 tcaaacagct tccgtacggc gatcaaaccg atccgaaaac cgttgtcggc ccgctgatca 3645301 acgagcgcca aatcgagaaa gcgctggaga tcattgagca ggcaaagaca gacggcattg 3645361 agcttgcggt tgaaggaaaa cgcgtcggaa acgtgctgac gccgtacgtc tttgtcggtg 3645421 cggacaacaa cagcaaaatt gcccaaacgg agctgtttgc cccaatcgca accattatta 3645481 aagctggcag cgaccaggaa gcgattgaca tggcaaatga tactgaatac ggcctcagct 3645541 ctgcggtttt cacttctgat ttagaaaaag gcgaaaagtt cgccctgcaa attgacagcg 3645601 gcatgaccca tgtcaacgac cagtccgtca atgattcgcc gaatattgcc tttggcggaa 3645661 acaaagcaag cggtgtcggc cgtttcggca atccgtgggt cgtcgaggaa tttaccgtga 3645721 cgaaatggat ttcgatacag aagcaatacc gcaaatatcc gttctaaatg aaaaaatccc 3645781 tctgtttcaa gtacagaggg atttttcttt atttagatat atccacaaac ccttcgccaa 3645841 acacatcgcg tacgtcatgt acgatcacaa acgctttttt gtcgcagctt ctaatgattt 3645901 ttttcagcat agacagctcc tgtttgttaa tgacgatata caaaatctct tttgactggc 3645961 ccgtataatt tcccttccct gataaaatcg tcacgccccg atccatcaag gtatttacct 3646021 gctctgcaat ctcactctta ttttctgaaa tgaccgtaat ggcttttttc gtattcaaac 3646081 cttcaataat gaagtccatc actttggtac cgatatacag catcacgatc gtaaacatca 3646141 ttttttctgc accaataata aaataagagc taaatactac gattaaatca aaaaacaaga 3646201 gtgcatagct gatattccag tctaaatatt tattagcaat tctggccaga atcgcggaac 3646261 cggccgtcgt cccgccgacc cggataatca tgccgatccc gactccggca aatacacctg 3646321 cgaaaatcgt attaatgatc aattcatcag acggaatgct ccacccatgt gtcagatgaa 3646381 gaaaaagcga atttgccgca accgcaatga tcgtataaac cgttgttttt ccatcaagaa 3646441 acttgtagcc gattaaaagc aaaaacgcat ttaagataaa gttcgtgaca ccaggagacc 3646501 attgaaacag ataatacaaa atcagcgtaa tcccagtgac tccgccttcc ccaagatcat 3646561 tgggaatcgc aaataaatta accgcaagcg cgaagaaaaa agcgccaatc acaagcataa 3646621 gtacatccag cattctcttt ttcatcacga aaacactcct tttcattgtt ctgttctagc 3646681 aaataaaaaa acccaggaga acgctctcga aaaagagcag aaactcctgg gcttttatcc 3646741 caccgtgtca taacagccaa gctgctatgt gttttctctc ggtcacagtc caatttgcat 3646801 tgcggaaccc tagaaaacca ctgtttttat catatccttt tcactttcca atattagcat 3646861 tataagggac ggttcgaatt ggttcaaggg gtatttgcgg agttttcatc agataagctg 3646921 gaaaaaaata cgatttatct attaaaaaag aacagatata accgataaga aaaaaagcat 3646981 atattttaca agcgaatgta actataaatg ataataatta taagaaattc ataattttat 3647041 attgactaag agaaataata taggcattat agtacatatg tttcgtacat tttattacat 3647101 aggaggaaat ataatggcag gaaaactagt accctgtaaa gcttgcggtc aagaaattgc 3647161 aaagggtgta aaaaaatgtc ctaactgcgg taaggatcaa cgtaactttt ttatgcgaca 3647221 taaaatcatt acgtttattc tcgcagttgt tgtcatcatt attatcggta atatgattgg 3647281 cggcggaggc ggctcagaag ccacttccaa aacatcaagc agcagcaaag cagaaactga 3647341 aaaaacatac aatatcggtg ataccgtaaa aactgaaaaa actgaagtga cggttacgaa 3647401 ggtagaggac agagatactg tcggtactca atatgttgaa aagaaagcat ctgagggagg 3647461 tacaattgta gctgttcaat atacaattaa aaacgtatct aaaaagccga ttagctcttt 3647521 ttcaattcca actgttaaat tagttgatgc tgatggtact tcttatgatt ctgatattga 3647581 tgcttctgta aactatgcaa ctgagacaaa agttgataac tctaaaattt tgagtgatct 3647641 aaatcctaat attaaagtaa caggtgtaaa agcatttgaa gttgacaagg aagcttatgc 3647701 aaaaggcact tggaaactaa aattcagtaa tgatgttatt gtgaaaatca aataacagct 3647761 aacaagggtg cctgtttagg cacccttgtt ctttaaaaaa ggccttctca attgagaagg 3647821 cctccattct tattccgcac tcttataccc attcacatta gaagactgcc atctccagga 3647881 atcagcacac atttcctcaa ggccgcgttt cgcttcccag cctagttctc gcttggcttt 3647941 cgcaggatct gcaaagcatg tggcgatgtc tcccggacgg cggtccgcaa aacggtatgg 3648001 aacctctttc cctgacactt tttcaaaggc tttgaccatt tccagcacgc tgtagcctgt 3648061 gcctgttcca aggttgtatg catcggctcc tgtagagttc aatacttttt ccagcgcctt 3648121 gacgtggcct tctgcgagat caacgacgtg aatataatcg cgtacgcctg tcccgtcttt 3648181 tgtcggatag tcatttccga atacgcttaa ttgctcgagc ttcccgactg ctacctgtgc 3648241 cacatacggc ataaggttat ttgggattcc gttcgggtct tcaccgatcc gtccgcttgg 3648301 atgcgcgccg aacgggttaa agtaacgaag cagcgcaacg ctccactcat tgtcggctgt 3648361 atgcaaatca cgcaatattt gttcaagcat gagcttcgtc tgcccataag gatttgtcgc 3648421 gcctaatgga aagtcttccg taatcggcga tgtttccgga acgccgtata ctgtcgcaga 3648481 tgaactgaat acgattttct tgacgccgta tttctccatg gcctcgcata aaataaacgt 3648541 tcctgtcaaa ttgttatgat aatatttgag gggaatcgcc acagattcgc cgactgcttt 3648601 taaccctgca aaatgaatca cagcttcgat ttcattttca gcaaaaacgg aatctaccgc 3648661 ttcccggtcc aataaatccg cttcgtagaa cgttaaatct tttcctgtaa tctccttgac 3648721 acggttcagc gcttcagctg aactgttgga cagattatca agaacaacaa tctcgtagcc 3648781 gctgttcaat agttcaacac atgtgtggct gccaatgtaa ccggcaccgc cagtaacaag 3648841 tattgccatg atgtaaaccc tcctaaaaaa tgacctgttt tcattatata gtgtttagaa 3648901 ccggtccaca tccattttta agaagtttaa tcgtttatta atagtttttt catatttttt 3648961 agcttaaacc cttgccagca attcgataga ggtttcagca agaatgtgct ctttcatttc 3649021 ttgatagagc tcattcaagt aaaagcccgg ctgaagattc agctcagcat ctaaagcata 3649081 gaccgtcaat gtatacgcat gatccttgtc aggcggtgtc ggcccgcaat actggtgaat 3649141 cacctttgga tcgttgcttc ccgcaagcgg tgaagcaaag ctgttttgcc cttgtatcat 3649201 caagtcctgt ctttcctcac tcgcatgttc aggaagctct ccgatgtaag ccggaatatt 3649261 agccgctgtc cagtgaatcc agctgaatcc gcatacggga atggcgtcat gatcgatgaa 3649321 agtaagtgcg agcgtctttg ctccggacgg gatgtcatca aaatgaattg gaaaggatac 3649381 aaatgggttt ccttctctct tatatttttc atccgcgtat tttgaatact tgtcatgtaa 3649441 atatggattt gcttctacgt atatgttcat atgaatccct ctctctattt tctcgttcta 3649501 taggtatact aaacgaatcg atgtataatc agtgataaac aaatacgcat gtaaacgtaa 3649561 caatttgtta tggataactt gcagtgaagg agatatttca tggatttaaa atggctgcaa 3649621 acctttattg ccgcagcgga atcagagagc ttcagggagg cggctgagca tctgtatctc 3649681 acacagcctg ccgtttctca gcatatgagg aaattggaag atgaactgga catgaggttg 3649741 tttttgcata gcggaagacg agtcgtactg actgacgaag gcaggctctt tttgccttat 3649801 gccaaagaaa tgatccatgt ttaccaagct ggaaagcaga aagtcagtca atggaaacag 3649861 gggtacagcc gatcactcac gctggccgta cacccctaca ttgcgtccta tatcttgcct 3649921 cgctttctgc cagcctatat ccaaaaacat ccgcatgtcg agctttcaac tcatgtggct 3649981 ggatctgacg ctattaaaca agcggtggaa cacaatgaag ctgatattgg tttgtcgcgg 3650041 aaagacccga acaccaacac tctttattat cagcatatat gcgaaggtac gctttgtctg 3650101 gcggctcctt tccaagaaag cagaccggat gctgcatccg tcttaacccg ctatcggctg 3650161 ctaacgcatg atcatccgtc atatggggat gcctttttag ataacatccg atcacattac 3650221 ccgtatcttc aaatgatggc tgtcgggcag acggatacgg ctgtccacat gatgaaagcg 3650281 ggaatggggg catctttcct ccctacctac attatcaaac aggaagaagc cgaaaaaaag 3650341 ctgatggctg tcagcacgcc tgcacatcta gaattgcctg cgtcccaaac gtttatgatg 3650401 tggaaaagaa acagcgaaga cattcagcat tttcacgcca tgttacatga ctttatgcag 3650461 cgcgaacaag tatagagctg aaaaatcaat ctgccggttg acgtttttct ttcctatttt 3650521 cgctatgctt aatgcagaaa ggatttgatg acatggcgat gagcccttat atttttattg 3650581 tattgattct tattatttta tcgatgtatc gagaaagaac ggtaaagccc gggaagttgc 3650641 tgatcattcc actgttgctc ttatggggcg tatctgcatc gtttcagccg gcgtattttc 3650701 attccgtatt acatgtggcg atcagcggca ttttattact gatcgggctg gcctgcgggt 3650761 ttggcattgg gaagatggta aatgtacgga ttcacccgga aaccggaaag gtcacttcac 3650821 gcggctcact tgggagtgtt atcctcattc tagtgatact ttctttgcgc atggccgcga 3650881 gaacatggct gcctgagagc aacgagatgt ttattgccat tattcattct atgttcttcg 3650941 ttcccctcgg caccatcaca gcccgcaaca tcatgcttta caaagcatac agacgactga 3651001 ccgctggcaa agtatccatt caataaccga aagaaggacc agcatgaacg gacaaactcc 3651061 ggctcggcac tactacaaga agcttgtgcc gagccttatt ctcattttga attgcataca 3651121 atttttatct catccaacta aggctgatcc cattttgtta gcatttgtat ttgcggtata 3651181 cttagcattc atttggatca ttccctatgt ggcatccact gctgttagtt tgagcatatt 3651241 catcggactc tggctcctga ccgatttctt ttgggctgtt tccggccaag agcagggtgc 3651301 cgcctatttt ttgattgtat ttttaatgat atatgccgcc tttagactcc cttcacggct 3651361 atccttgatc ttcacagcat gtttaattgg aggcaacata ttactcctat cctcacaagg 3651421 gggaagcttg aataccatca tcagcaacat ctcgatcatg ctcggtctgt acgtcctctt 3651481 ctcctccatg cgtttcagac gagaagcgag aagggaggct gaacggaatc atgctgaatt 3651541 ggcaaaaatg catgtgcagc tggagcatgc tcataaagaa ctccagaaag cgcatgcaga 3651601 gctgcaggag gcttctgttc tttcattaag gtacgcggtc cttgaggaac gtacaagaat 3651661 tgcccgcgac attcatgaca gcatcggtca cgagctgact tctgtgattg ttcagcttca 3651721 atcccttccc tatatcctta aaagcagcaa ggaggattca gaaaaagtca ttcaaaatgt 3651781 actgagtgtc gccagggagt gtcttcaaga agtgcggtct gttgttcacc aaatgggccg 3651841 tagtgaatcg atggtggggc ttaccgcttt gcgggggctc attcatcaag tggaggaacg 3651901 gagcggcttg cacgtttctt tagatactgc cggactgtca gaagagtctt ggcctccaaa 3651961 cgtgagcgaa acgatctacc gcatcttgca ggaagcgctg accaatatca ttcgtcacgc 3652021 tgacgcttct catgcggcgg ccgtcatttc taatgacaag tcccatctct atgtcacaat 3652081 caccgacgac ggacaattca ccggcagcct tacttatgga tttggcctga caggaatgaa 3652141 agagcgcgca gaaaaagcag gcggttccct tactttcagt gccgtacagc cgagcggcct 3652201 gaaaattgag ctgtcattgc cgctcatgac aacgaataag gagcaaaaag atgaacaaag 3652261 ataaaatacg cgtagcgctt gccgatgatc agccgcttgt gcgtgaaggc ttccgctacg 3652321 tcatcaacgc acagacggat atgacggttt ctggcgaggc cggcgacggt cacgatatta 3652381 tagcactcgc aaaacaaaca aaacccgatg tcatcctcat ggatgtccag atgccgcgtt 3652441 gctcaggcat cgaagcggcg aaagacatta tgtccgcact tccaaataca aagatagtca 3652501 ttttaaccac ctttgacacg gaagaatacg tatttgaagg catccgtgcg ggcgcagtcg 3652561 gctatctgct gaaggataca cttcctgagg agttgataga tgcgattcgc gctgcggcca 3652621 gaggcgaggc gattttccgt acagtcacag ctgctaaaat catcagtgag acatttcggg 3652681 cgaaacagca aactcatgcc gaagaactgg cagagccgtt caccaaaaga gagcttgagg 3652741 ttcttcagca aatggcctac ggactgagaa atgaggatat tgctgaaaag cttttcgtca 3652801 gtgaaagcac tgtgaaaacc cacgtgcacc gcatcctgca aaaatgcaat gcccaagacc 3652861 ggacacaggc agtcgttttt gccattcgaa acggtattgt gcaatagaaa tctctcatcc 3652921 cgccatgcta aaataagaca aaggagatga ttggaaatga aagaagaaat cattgaacgg 3652981 tttactacat atgtaaaagt cgatacacag tccgatgaat ccgttgacac ttgtccttcc 3653041 acacccggcc aattgacatt aggaaacatg ctagttgatg aattgaagtc catcggcatg 3653101 caggatgcag ccattgatga aaacggctat gtcatggcaa ctcttccctc caatactgaa 3653161 aaagacgtgc cgacaatcgg ctttctcgct cacgtcgaca ccgctacaga ctttaccggc 3653221 aaaaatgtga atccgcaaat catcgaaagc tatgatggaa aagacatcgt tcttaacgaa 3653281 cagctgcagg tcaccctgtc acctgatcaa ttccctgagc tgtccggcta taagggccat 3653341 acactcatca ccacagacgg caccaccctt ctcggcgcag acaataaggc cggtatcgct 3653401 gaaatcatga cagccatgga ttacctcatc aaacaccctg aaatcaagca cggcacaatc 3653461 agagtcgcct ttacgcctga tgaagaaatc ggaagagggc cgcacaaatt tgatgtgaaa 3653521 cggttcaatg catcctttgc ctacacggtt gacggcgggc cgctcggcga gcttgaatat 3653581 gaaagcttca atgccgctgc cgcaaaaatt acgattaaag gcaacaacgt acatcccgga 3653641 acagctaaag gaaaaatgat caactctgcg aaaatcgcga tgaagctgaa cagcctgctg 3653701 ccggcagacg aagcgcctga atatacggaa ggttatgaag gcttctacca cctgctgtcg 3653761 attcaaggag acgtagagga aacaaagctc cactacatta tcagagactt tgacaaagag 3653821 aatttccaaa acagaaaaga aacaatgaag cgtgccgttg aagaacttca aaacgaatac 3653881 gggcaagacc ggattctgct ggatatgaac gaccaatact acaacatgag agagaaaatt 3653941 gaacctgtca tcgaaatcgt caacattgcc aagcaagcga tggaaaacct cggcatcgaa 3654001 ccgaagattt cccccatccg cggcggaacc gacggatcac agctgtccta catggggctt 3654061 ccgacgccaa acatctttac aggcggggaa aacttccacg gcaaatttga atacatctca 3654121 gttgacaaca tggtcaaagc cgtaaatgtc atcgttgaga ttgcaaagca gtttgaagcg 3654181 caagcataac gccaaaagcc agtccaaaaa aggactggct tttttgtgtg aaaatgaaac 3654241 attttaaaca cgtcctccgt aaaacaagta tcaacaaatg aggaggaaaa acaatgacaa 3654301 aacatgcaat cgctgccaag agtctcttga aaaaatggat catttccagg ccgcttaaca 3654361 tgaaaaagaa atccagccca tttcaaaaaa tcagaaaaat gttcaaacgc ttcttcaaat 3654421 aaaacatcaa atcccctaaa tacaatccgt attcacccgt accgcccaaa tgctccgtaa 3654481 tttgggtttt ttgtgttcaa ttccgcaaaa tagggtataa accaaacaag caagaaaaca 3654541 gcacccaaaa acaggtaatt cgaattacgt aaacttaggt taaaagttat ataaaggaat 3654601 ttattttatc gtcgatagta actatagaac caatcatcaa caagagcaaa cagcgtaatt 3654661 caagactatt ttcaggtcat caggtaatac tgttttagag ggacagtttc ttgttattta 3654721 ttgatttaga attttttgaa tactttttgg cattttatcc gtacaataga gagtaccaaa 3654781 actttttttg ggaggtatgt aatatgatcc tatttattat catcgcatta tgcggctatc 3654841 ttcttttttc tttcagcaag gacaatcgcc gcaaaccgca aaagacaagc cctctgccag 3654901 cagccgcacc tcatcacaac aacctaatcg accttgacgc catccgccaa aaacgccgga 3654961 tgcatctttc ctaattctat atttcaaacg aaaaggctgc tgaatcacgc agccttttaa 3655021 aattgttttg atttagagcc tgaaaccttt tcgccaccta tccgtaattt catacaaggc 3655081 aaacccaaag gagacttcag caatgatcga gttatttatg aaacaaaaaa tgttctcatt 3655141 taaagatgca tttcacattt atgaccggga tgaacaagaa acattcaagg tggaggggcg 3655201 ttttttctcg ttaggagact cattacaaat gacagactca tctgggaaaa cgctcgtttc 3655261 catagaacaa aaactaatgt ctttattgcc gcgctatgag atttcaattg gcgggaaaac 3655321 agtttgtgag gtaacgaaga aagtaacgtt ttccaaaccg aaatttgtga tttccgggct 3655381 taactgggaa atagatggtg atttatggag ggatgaattc caactgacgg acggggaaaa 3655441 tgtccggatg tcagtgagca aaaagtggct cagttggggt gattcctatc acttgcagat 3655501 tgcatacgag gaagatgttc tgatttgcac tgccatcgct atcgtgcttg atatggtttt 3655561 atataacgat gaagatgaaa gtattttcta aaaagcattg acaattgatc caaaagtaat 3655621 aatattaaga taattgaaat ctgaatatga agttgtacct tatcaagaga ggtggaggga 3655681 ctggccctat gatacccggc aaccgctgtt tcaaacagaa tggtgctaaa tccttaagaa 3655741 cattgcgttc ttgcagatga ggcggagatt tgatcgttca agctcttcct tacacaaagg 3655801 aagagctttt tacatgctta atatttcaga aaagaggcga ataacatggc tcaacaaacg 3655861 aatgttgcag gacaaaaaac agaaaaacaa cgcaaagcac ctttccgcgc cgatcatgtc 3655921 ggcagcttgc ttcgttccgt tccggtaaag gaagcccggc aaaaaaaagc ggctggtgag 3655981 atgacagcgg aacagcttcg tgatatcgaa aatcaagaga tcacccgcat cgtggaaaaa 3656041 caaaaagaaa tcggtctcga tgtggtaaca gacggggaat tccggcgttc ctggtggcat 3656101 tatgacttcc tggaagggct tgacggtgtg gaaccgttca tcccggctga ggggattcag 3656161 ttccataaca caaaaacgaa agcgcgcagc atcaaagtga cgggaaaact cgattttacg 3656221 agccacccag cgctcggtga ttatcaattt ttacatgaga ttgccggtaa cgcgacgcca 3656281 aaattgacca ttcccagtcc aaatatgctg ttttttggcg aaaaggcgga taaagggatt 3656341 tatgacgatc aagaggaata ctttcatgat atggcccaag cgtacaaaaa agcaatcaaa 3656401 gccttctatg atgctggctg ccgttatctc cagcttgatg atacgtcatg gtctctcttc 3656461 tttgaggaca aaggcagaga ggttgtccgg gcgctcggcg gtgatccaga aacattgcca 3656521 gccatatttg ccaaaacaat taacgatgcc gtcgcagacc ggcctgacga tttaacgatc 3656581 acaatgcaca tttgccgcgg caacttccgc tcaacctggg cggcatcagg agggtacgac 3656641 gctgtagcgg aaacgatttt ggacggctta aaccttgacg gccttttctt ggaatacgat 3656701 gatgaccgct ccggaaactt tgatccgctc cgttttgtga agcgcaagga tctgcaaatt 3656761 gtgctcggct tgatcacatc gaaatacggc gagcttgaaa atcctgagga tgtgaaacgc 3656821 cgtatcaatg aagccgcgcg ttttgtcagc ttggaccagc tatgcctgag cccgcagtgc 3656881 ggtttcgcct ctacagaaga aggcaacctt ctgacagagg agcagcaatg ggcaaagctg 3656941 cgccatgtca tcgacattgc caacgatgtg tggagataat ctatcattga cagaaataga 3657001 aaatgtgtga ataatagata ctatcagaaa atttaataaa aaggttttcc ttatcaagag 3657061 aggtggaggg actggccctg cgatacccgg caaccgctgt ttaacagaat ggtgctaaat 3657121 cctttagagc aatgattgct cttgaagata aggttgagat tgtcacgcaa gctcttcctt 3657181 atccaaagga agagcttttt tatatttgaa tggaaagaag gaatggacaa catgtcacaa 3657241 caaacaacac ccgcagaaca aaaatcactt caaagaaaaa aaccgccgtt tcgcgcggat 3657301 caagtcggaa gcctgctaag atctgagccc gtcaaaaaag cgcggctgca aaaagcggcc 3657361 ggcgaaatga ccgctgagca gcttcgccaa attgaaaacg acgaaatcat ccgcattgtg 3657421 gaaaaacaga aggaaaccgg cctgaacgtc gtgacagacg gtgaattccg cagagcatgg 3657481 tggcactttg atttcctgga aaacttagat ggcgttgagc cgtttactcc tgagcaaggc 3657541 attcaattcc ataacgtaca gacaaaagca cgcggcatta aagtcacagg cgatatcgac 3657601 ttttcaactc acccaatgct tgaagattac tcatttctcc atagcattgc cggtgacgcg 3657661 acgccaaaga tgacgattcc aagtccgaat atgctgtttt tccgcggaaa actggaaaag 3657721 gatgaataca aaaacgatta tcaacttttc cagcacgatg tatccaaagc atataaaaaa 3657781 gcgattcaag cgttttatga cagaggctgc cgctacctcc agcttgatga tacagcgtgg 3657841 gccgttttct tatcagaaaa aggcttaaaa caaatcgaag cgttcggaac aacgcctgac 3657901 gagcttcgcc agctgtttgc gaaatccatt aacgacgcga ttgcagaccg cccggatgac 3657961 ttgacggtaa ccatgcatat ttgccgcggc aacttccagt ccacttggac agcggaaggc 3658021 ggctatgacg cagcagccga aaccattttt gacggcttga atcttgacgg acttttctta 3658081 gagtatgatg attcacgctc aggcggattt gagccgctcc gttacgtaaa acggtctgat 3658141 cttcagcttg ttcttggctt agtgacatct aaattcggtg agcttgaaaa tccggatgac 3658201 gtgaaacgcc gtatcgaaga agcgtcccgt tatgtaagct tagaccagct ttgcctcagc 3658261 cctcaatgcg gattcgcttc aactgaggaa ggcaacaagc tgactgaaga acagcaatgg 3658321 gcgaagctcc gccatgtggt tgagatcgct aatgatgttt ggaaataagc aaagaaaaaa 3658381 acacacttga ttccctagcg gagcaagtgt gttttttatg tcattgtgcg gtgtagcccc 3658441 catcaaggac gacagcctgc ccagtgacgc ccttcgcctt ctcgcttgcc aaaaacacgg 3658501 cataatccgc aatttccttg acggaaagca gtcgcttttg cggcacaagc ggaaaaatga 3658561 cttgttcaag tacagagtcg taagggacat ttctagtttt cgatagatcg ctaagctgat 3658621 tgcgtacaag ctgggtatcg acataacccg gacagagcgc attgactgtt atgccgtggg 3658681 gcgcgccttc cagcgcccct acttttgtga gtccaatgac gccgtgcttg gcgctattat 3658741 aagcggattt ccctgcaaag cccactaatc cattaacaga cgcaatatta atgattctgc 3658801 caaactgctg ttttttcatg atcggaaaaa catgcttcat tgcaataaag ggagccgtca 3658861 gcatgacctt gatcagctgt tcaaaggtgt ctgtcggaaa ctcttcaatc ggagcgacgt 3658921 gctgaatacc ggcattgttc accagaatat ccaagcggcc gtattgtttt tggatgacgt 3658981 tcaccgtatc agcaacttgc gcttcctttg tcacatcata cggaatggcc gccgcgtcaa 3659041 agccttcttc tgcaagcttg gaggctgctt tttcacatgc ttccggacgg aggtctgaaa 3659101 cgatgacgct ggcaccttcc cgggcgaatt ctcttgcgat ttcgaatccg attccgccgg 3659161 cagcccctgt caccaaagcg acttgttttc tcatgtcaaa caccttccca ttaagaattg 3659221 agtacagact ggcttacagc gaaatcagct tctgtttttt cataaacctc ttcaattgtg 3659281 acaccatcct gaagctccgt cagtgtcatg cggccgttca caaaatcaaa tacagccaaa 3659341 tccgtaatca gcctgtgtac gactttctgg cctgtcagcg gaagggagca tgtttttttc 3659401 acctttgatt caccatgctt attgacgtgc tccatgatga caacgattcg tttcgccccg 3659461 ttgacgagat ccatggcgcc gcccatccct tttaccattt tgcccgggat catccaattg 3659521 gccaaatccc cctgctccga aacctccatt ccgccgagaa tagctaaatc gatatgcccg 3659581 cctcttatca tcgcgaatga ctcagcgctg tcaaaataag aggcgcctgt cacttcagtg 3659641 atcgtttcct ttcccgcatt gatcaaatcc gcgtcttccg ttccttccag aggatagggg 3659701 ccaattccga gcaagccgtt ttccgactga agcatgacgt gaacgccatc gggtatctca 3659761 tttgcgacaa gcgtcggcat tccaatcccg agattcacat tcatgccgtc cttgatttct 3659821 tgtacagccc gtttgaccat tcgttttctc gcttccttca cttggcctca ccctttcccg 3659881 atgcttgctg aactgttcgt ttttcaatcc gtttttcttg gctcgcgcca agcacgacat 3659941 gctgtacgta aattcccggc gtatggatgt gatctggatc gagctctcct gcttccacga 3660001 tttcttccgc ctcggcaatc gtgatcttgc ctgccatggc ggcaatggga ttgaaatttc 3660061 tcgccgtttt cctaaaaatc aaattgccca tggtgtccgc tttccacgct ttgacgatcg 3660121 ccacatcgcc ggtaatgcct cgctccagca cataagtccg gccgccgaat gttttatgtt 3660181 cttttccctc ggctatggag gtgccgacgc ctgtcgccgt ataaaatccc ggtatgcctg 3660241 caccgcctgc acgaattctc tcagcgagcg ttccttgggg aacaagctct acctcaagct 3660301 ctccgcttaa aaactgccgc tcaaaaattt tattttcacc gacataggaa gcgatcattt 3660361 tcttgatttg cttgttagcc agaagcaaac caagccccca gtcatcgact ccgcagttat 3660421 tgctgacaac ggttaaatcc tttactccct gatctcttat agacaaaatg agctgttcag 3660481 ggatgccgca cagcccaaac cctcccgcga tcagcgtatc cccatcatga atcagtttcg 3660541 cagcttcctt gcttgatgac agcacttttc ccatattgat gcccctttcg ttttcttcta 3660601 cactagacca gtcaggctgt aaatcgcgat cacagcaaat acggcagccg ttttaatgag 3660661 cgtgatcgca aaaatatcgc gataggattg ccggtgggtc aaacccgtca cggccagaag 3660721 cgtgataacg gcgccattat gcggcagtgt atccatcccg cctgatgcca ttgaaatgac 3660781 ccgatgcatc acctctggcg gaatattgta agcctgaatc gcctgtaagt attgttctga 3660841 catcgcgctt aacgcaatgc ccattcctcc cgaagccgag ccggtgattc ccgccagcgc 3660901 agttgtcgta acggcgccat ttacaagcgg atcggtaaaa gtatgtgaaa ttccgctgct 3660961 cagcttatga aaccccggca gcgcggcgat aatgccgccg aacccgtact cagcacccgt 3661021 attcatagat gccagcaagg cgccgccaat tccttcattc agcccttcct tcaattgggc 3661081 aaacacactt ctccaatcaa ataatatcgt tgtgatgatg ccaatcacta aagcaatctc 3661141 caccgaccaa atagcagccg ctgaagaaat atcaagcctg ccgaactcct ttaatcctat 3661201 ggaagaaaaa tcaaatccat tcggatacca ctttggcagg taaatggtga aatatttatt 3661261 cactgcaccg acgagaataa gcgggacaaa ggcaagcgcg tgccgaatcg ggcttttgtc 3661321 cggttcagcc gcggactcaa tcgattcagg agcaggagca ttctgcgaat caaaaccgcc 3661381 atagccttcg ccagatgcct gcgctttctt ccgccttgat tccaaataga gcatcccagc 3661441 tgccagcaca atcactgcgc ccatcaaacc cagccaaggg gcggcataaa tgtctgtttt 3661501 gaaaaacgac gtcgggatga cattttggat ttgcggcgtt cccggaagtg cgtccatcgt 3661561 aaacgtaaaa gctcctaaag caatcgtacc cgggatgagg cgttttggta tgtttgcttc 3661621 ttggaacatg tttttcgcaa aaggatatac agcaaatacg acaacaaaca ggctgacacc 3661681 gctgtacgtc aagacagcac ccatcagcac aatggcaagt atcgctcttt ttgccccgac 3661741 aagccggaca attgttttcg cgattgatgc cgcaagcccg gccatttcaa cgacctttcc 3661801 aaaaatagca ccgagcaaaa acactgggaa atacagctta ataaaacccg ccatcttctc 3661861 cataaaaatt gatgaaaaaa aaggaagcac atggcttgga tctgtcagca gcaccgcgaa 3661921 taacgcgcaa atcggcgcaa acaatatgac agaaaatccc cgatacgccg taaacatcag 3661981 caaacctaac gccaatagaa tgatgatcag ttccacacac acatcccccg tttccgcgaa 3662041 ctagaaagcg tttacaaaaa cctgtccgca tcggctgttt ccgtcccctt tccatatgta 3662101 cgagaagcgt gggccaacta ttccgattaa aaaaggaaag ctcctttttt cggagctttc 3662161 ctctaccatt catttcattc ctattaggat atcaacatca accgtaatat cggctgattt 3662221 catctctttc agcaggctga ctcgatcttt cggcgccgac caggcaagcg gcgtcatctt 3662281 gagaagccag tggatcgcct gctggtcaag cgttttaaca tagcgcagcc tgacaggacg 3662341 gctgtgtgct gcatttgctg taaaacgctc aactgctgcc gtattggaat acgtgcgcct 3662401 tggtgaatca gtatataaaa attgccttaa ttctattaaa tagtcgcttc gcggcactac 3662461 ttttatgagc atgccatcat tcttcagcag tctatgaaac tctgcataat tggacggcga 3662521 aaaaatagac agaacaacat caaattggcg atcatgaaaa ggagcacgcg ccacatcggc 3662581 aaccgcccac atcagatctt tgaatgcctt agaagctttt aagatcccgt ccttcgaaag 3662641 atctatgccg gttcctatcg ctgctttccc tgcataatca aacccgcaaa gcgcattcaa 3662701 atgagaaccc tcaccgcaac cgctgtccaa gatggtgaat gcctcatgac cagatttggg 3662761 atgactgatg agctctgcaa tcgcatcatg gagcgggtca aaaaaaccac attctccaat 3662821 cagcctgctc ctcgcttcaa aaagctcggc accgtaactg gttttgaccg gcttcgtcag 3662881 aaagttcacg tagccgtgcc gagatagatc aaatgtatgt cctcgttctg tacaaatcaa 3662941 gcttttccct gatgccgcat ccatagaaga atcgcagagc gggcatcgaa acatgctgaa 3663001 atcaactgtt cgcttcatga taaaaaacac cccattcatt catttttaga taaatgaaaa 3663061 aggcatagac aaataaacct aggcctatct caaaaattgg ccaggtctgg cagtttgtct 3663121 acacctgtca ttatctataa cgaatgaatt ggataatcat gaaaaaaact ccctttctgc 3663181 tgtatgggtt tccccgtttc catcatacaa caaatatcca ggagctggaa ccttatagtg 3663241 aagaaaaatc agtactgaca tgctggtatc ccgccaacat catatcagca tagcaatcca 3663301 gcatgttttt cctttatttt ctcattttag aatataaatt ttattattgt gaaaatagtt 3663361 aaaaaggttg attttcaaaa agtgaaagga taaaatactg ctatcatctt agaaaaagac 3663421 attcttgtat atgatcagta atatggtctg attgtttcta cctagtaacc gtaaaaaact 3663481 agactacaag aaagtttgaa taaatttgaa cgagttgaaa aggacaagtt cttttctgtt 3663541 tgctcttatt tttcacactt tctgcacttc cagaatttgt gaaggataag agcttttttt 3663601 gtttccataa taaccctcat aggagttgct atcatgtact ttttactaaa ccttgtcggt 3663661 ctcattgtga ttatggcagt tgtattccta tgttctccgc agaaaaagaa aatcaagtgg 3663721 cgcccgatca ttacgttaat tgttctggaa ttgctgatta cttggtttat gctgggaaca 3663781 aaagtcggaa gctgggccat cggtaaaatc ggtgatttct tcacttggct gattgcttgc 3663841 gccagtgacg gtatcgcgtt tgcctttccg tcagtgatgg cgaatgaaac agtagacttt 3663901 ttctttagtg cgcttcttcc aattatcttt atcgtcacat tctttgatat tttaacgtat 3663961 ttcggcattt tgccttggct gattgataaa atcggatggg tgatttcaaa ggcttcccgc 3664021 ttgccgaaat tagaaagctt tttctctatt caaatgatgt tccttggaaa taccgaagca 3664081 cttgcggtca tccgccagca gcttacggtt ttaagcaaca accgcctgct cacattcggt 3664141 ttaatgagca tgagcagcat cagcggctcc attatcggat cttatctttc aatggtgcct 3664201 gcgacatacg tgtttacagc cattcctttg aactgcttaa acgcgctgat tatcgcaaac 3664261 ctgctgaatc ctgttcacgt gccggaggat gaagatatca tctatacacc gcctaaagaa 3664321 gagaagaaag actttttctc tacgatttct aacagtatgc ttgtcggcat gaacatggtt 3664381 atcgttattt tggcaatggt gatcggatat gtcgcattaa cgtcagcagt taatggcatt 3664441 cttggcgttt tcgtacatgg cctgaccatc cagacaattt ttgcttatct gttcagtccg 3664501 ttcgcattcc tgcttggact gccagtgcac gatgcgatgt atgttgctca gctgatgggc 3664561 atgaaattag caacgaacga gtttgttgcg atgcttgact tgaaaaacaa tctcaaatcc 3664621 cttccgcctc acaccgttgc ggtggcgacg acattcctga cgtcctttgc aaacttcagt 3664681 actgtcggca tgatttacgg cacgtacaat tcgatccttg acggagaaaa gtcaacggtc 3664741 atcgggagaa acgtgtggaa actgctcgtc agcggaattg cggtatcttt attaagtgct 3664801 gcgattgtcg gcctgtttgt gtggtagaaa cattgagcca tatccctttt cggatatggc 3664861 tcttttcatt attgataaat agaggctggc acctgcacat cccggattcc cgctgcataa 3664921 ggccccaagt catactggcc gaagacgatg gcgatcccgt ttgccgtaaa gtaaaacatt 3664981 gtgtctctgt ttagggttat atcctctttc tttacatcag agaaaaacag cacatcgtgt 3665041 tttttgatat agctatatag gtaatctctc gttttgctga cttttgtttt ggtgttcaga 3665101 atctgatcca gcgtcacccg cttttgtgct ttcaagtcat agttgaagga ctggacagac 3665161 gttagaccgt gggcgccccc tgaatagata taattgagtg tttgaatgct gagcttgcct 3665221 gccgcattgt atttgacgct gaaggatgtt tgatattccc gttttaaagc cctgctgttc 3665281 gcctgctttt ttgtttttca ggtattcctg atacgattgt tcatgtaggc tttcagctct 3665341 tgattgattt tcttttcaaa cgcggcattc ccgacgtgat gcacttgtgg atacgttaac 3665401 tccttgatct ttttgtacgt atgggtgctg acagtcggtg ttttcgcttg aactgctttt 3665461 aaagatgggg ccgcatatgc aaatacagaa aaaagcaaga ctgcaatgcc cgcggctttc 3665521 agcatgttat tccatttcat acaatctact cctttgatgt cgttgtttat cattccctta 3665581 tttaagcaat acacactttt atagactgat taaatcgaaa gaagtttcta ggtctaacag 3665641 catgattttt ccaataaaaa aagagacaca ggatgtctct ttttttactg tttgcgccca 3665701 gaaatcgctt catgaagggc ttgtgccaaa tctgtatttc cgaacatctc taataccgca 3665761 atgacagtct ggtccggaat gtgctctgct tcgtgttttg gcacgaccag atcgtccatg 3665821 gtttttttca agctttcatt cagcttttgc tgcggatacg ctttggcgta cagctccatc 3665881 ggatcaagat catggttcac gcaccactgg gcaaacacca aaatcatcat attttcatcg 3665941 cgttcgtaag cttcagtgag ctgtttttcg ttcatttgtc atgctcctta tgaaaagtat 3666001 cttccttaaa gatacaggag ccgatcaaat tcgtctatcc caatggcgat gagcagcaac 3666061 cgcatcgata aatgccttgc tgaaagcggt gtagtcaggt tcatctttag ccgttacgat 3666121 gcctagcccc tctgttgtcc cgacagagga ttgaagaagg tcaattcctt catttgccgc 3666181 accgatcgcc ttgtagtgat tgtaagcttc tctgataaac gccatcgctt gtttgttgtc 3666241 ttttaactcc agtcctcctg cggcatagac ggcatcatac agaacagaat caaccgtcag 3666301 gaacgtgccg ctggcctcaa gctgctgtcc gctgccgctt gtcatatacc ccagattttg 3666361 actgatgata tccactgtga ttccttcttg ctttaaggct tccagtactg tttgcagctc 3666421 tttttcatga aatccgtttc cggcgagtac agcgactttt cttgttgacg cggttttcac 3666481 tgtacgggct tggcttaacg caggcgaagt aagaatttct ttagatgctt tacgcttcgc 3666541 gggcgccgcc acgcctactc ctttggcgat ttcttctgct aaatctgcat cgacattgct 3666601 gaagacatca acgacctgcc gctgtacgtc tttgcttttg accttcccga cctcgaagca 3666661 gaaagcagaa atgatgtgct gtttctccac aggagacatg ctgttccaga aaagcttcgc 3666721 ctgtgagtaa taatcgttga agctgtcgct tcgctggcgg atttttttgc cctcgacttt 3666781 ttcctgatag tggacgtagc cgccttcttc agctgtcgca ggcgacggat cattgttttg 3666841 cagtgagttt ttatgataag cgacaggtcc cttattgatc gtcatccggt gatagccgtc 3666901 gtattggttg ttatggaatg gacagaccgg ccggttaatc ggaatctcat ggaagttcgg 3666961 gccgccaaga cggatgagct gtgtatccgt ataagagaaa agccgcccct gcaatagcgg 3667021 gtcattggta aaatcgatgc ccggcacgac atttcccggg tggaatgcga cttgttctgt 3667081 ttccgcaaac acattatcct gattgcggtt cagcgtcatt tttccaatga tcttcaccgg 3667141 cacaagctct tccggccaca gcttagttgg gtcaagaata tcaaaatcaa acttgaattc 3667201 atcttcctca tcaatcatct gcacgccgag ctcgtattca accttgccgc cgttttcaat 3667261 tgtttcccac aggtcacggc ggtggaaatc tggatctttc ccggcaattt tttgcgcttc 3667321 atcccatacg agagaatgca cgccgagcac cggcttccag tgaaatttca cgaaacgtgc 3667381 ctttccttgt tcattgacaa aacggaacgt gtgaacgccg aagccttcca tcattctgta 3667441 gctgcgcggg atgcctctgt cagacatcgt ccacatcacc atgtgggcag actcagggtt 3667501 attggcgaca aaatcccaaa atgtatcgtg agcagtcgca gcctgaggca tttcattgtg 3667561 tggctcaggc ttaaacgcgt gaaccaaatc cggaaatttg attgcgtcct gaatgaaaaa 3667621 caccggaatg ttatttccca caaggtcata gtttccttct tcagtataaa attttgtcgc 3667681 aaagcctctg gcatcccgca ccgtgtctgc ggagccttta gaacccgcaa ccgtagaaaa 3667741 acggacaaat accggtgtct tcaccgaagg gtcctgaaga aatttggccc gtgtgtattc 3667801 cgtcattggt tcgtaaacct gaaaaaagcc atgcacgcca aatccgcgcg catgcacaac 3667861 gcgctccgga atcctctcat ggtcaaagtg cgtcattttc tcccggaaat gaaaatcctc 3667921 catcagcgtc gggccgcgaa ccccggcttt taacgagtgc tcatcctctg acactcgcaa 3667981 gccttggttt gtcgtcattt tcttcccgct gttatcggtc ctgtactgct caagctgctc 3668041 gtcctttgag tgttcattta cacgtttgtt ttggtcatca ctcatgtctg ctcccccttt 3668101 ttaaaacgaa acattctaca gcacatttac ccgtggcgtt cttcatataa actgctaatc 3668161 cgctcattag gatttttggt ctacatataa atatgcggtc atacacattt gaaataagcc 3668221 ttcttcacag aaagaaagga tggaagcgct taccaaaaaa gctgttgaat aggggaggtc 3668281 atatcatgct tgccatactc ggttttgtga tgatgattgt ctttatgtac cttattatgt 3668341 ctaaccggct ttccgctctt attgctttga ttgtcgttcc tattgtgttt gccctgatca 3668401 gcggatttgg caaagatctc ggcgagatga tgattcaggg cgttacagac ctcgccccta 3668461 ccggtatcat gctgttattc gccatcctgt atttcggcat tatgattgac tcaggcctgt 3668521 ttgatcctct cattgccaaa atcttatcgt ttgtcaaagg agatccgtta aaaatcgccg 3668581 taggcacagc ggttctgacc atgaccattt cgctggacgg agatgggaca acaacctata 3668641 tgattaccat tgcagcgatg ctgcctctct acaaacggct cggcatgaac cgtttggtgt 3668701 tagcgggaat agcgatgctt ggttcggggg ttatgaatat tatcccgtgg ggcgggccga 3668761 ctgcgagggt tttggcttcc ttaaaattgg acacgtcaga ggtctttaca ccgctgattc 3668821 ccgctatgat cgccggcatt ctctgggtga tcgccgttgc ttatatcctc ggaaagaaag 3668881 agcggaagcg gctcggcgtc atttcgattg atcacgcacc gtcttccgac ccggaggccg 3668941 caccgctcaa gcgtcccgct cttcaatggt ttaacctgct gctgactgtc gctctgatgg 3669001 ccgcactgat caccagcctg ctgccgctcc ctgttctttt tatgactgcg ttcgccgttg 3669061 ccttgatggt taactatcca aatgtcaaag agcagcagaa acgaatctcg gcgcatgcgg 3669121 gtaatgcgtt aaacgttgtc tcaatggtgt ttgctgcggg catattcaca ggcattctct 3669181 ccggcacaaa aatggtggat gccatggcgc attctctcgt ttcactcatc cctgatgcca 3669241 tgggcccgca cctgccgttg atcactgcga tcgtcagcat gcccttcacc tttttcatgt 3669301 cgaatgacgc cttttacttc ggtgtccttc ccatcatcgc cgaagccgct tccgcttacg 3669361 gaatagacgc cgctgaaatc gggagggcct ccttgctggg gcagcctgtg catctgctca 3669421 gcccgcttgt gccttccacc tatctattgg taggaatggc aggcgtcagc tttggcgacc 3669481 atcaaaaatt cactattaaa tgggccgtgg gaacaacgat tgtgatgacc attgcggcgc 3669541 ttttgattgg gattatttct ttctaaatgt atgagcttga tcgtagcatt gagtgagtac 3669601 gtgatttaca gaggggagaa gatcaaatag gatattatga gtgaatagaa gattcatgcc 3669661 aacaacttct cattacaatc ataagagcct gctatattgc agcaggctct ttcacatttg 3669721 gcattatttt tttgtatagc gcacccagtc ataatgagcg tatagcggat ttacaccatt 3669781 gtaggagcca agccattcat cgacacccgt gccattccac aagttcatca tgatctttcc 3669841 aggtgttgtc ggaatttggt ttgttgcagt atgttttaat tgcccgtcga cataccattt 3669901 aatagagttt ggctgccaat cgaatgcata cgtatgatag gcattggctg catcaaaccc 3669961 gagatcaaca atcttctcat ggtttcctgc accatttgta taatagttaa attgaacctt 3670021 cgttgtgtct tttcctaaaa attcgatatc aatctcatcc caaggagttc catctgttgg 3670081 acctgtgtaa gtgaagaacg atgaaacgat ccctgtgttt ttagctggtt tcattctgac 3670141 ttcataaagt ccatagccat atgtttgaac agaacggttt tccccgcagt caaacttgtt 3670201 ataagctggg cttgttagcg ctaaacgcat ttcacccaat gacgtcattg atacgttatt 3670261 agcccgccac gtgcagttga acatatttcc attcgaataa ccatctgctt tttgccaaaa 3670321 accggagtta tagccgttaa aagggtcaaa aaacgatcca cctgtttgag ctgaggcagt 3670381 agcagtgact gcaaacaaac tcataaacaa tccagtgaca agaagcagca acactcgttt 3670441 cagataaggc atattggcat tcccctttca ttgaaagcgt tttctatgtt gatcttacat 3670501 gattctttta aaagggaaca tcggtcaaaa taatgataat atcgaatctt actaacttga 3670561 atcctgtaac tatcatcatc ttccctctga aaaaaataaa aacctaaatt accatcagca 3670621 cagacagaga tgatccgcac tcattgcaat ttaggttttg cctgctttat cagtaacaat 3670681 cctaccattt tcatatgtga atgtaagaaa aagtgaacac aaggaaacac aaatgtcagc 3670741 gctctcatta tgcttgttta actacccttt ctatgtgaat ggttaaatac agcagctcgt 3670801 cacttgtgag cttgtgctca tactcccgct caatgtaggt ttggattttc ttcgtgcatt 3670861 catacgcgcg atgatacttt tctttcactg tatccagcaa aaaatcgtcc tggctttcca 3670921 tgtgagtgcc gttaaataga cgctgcgcga aaaactttaa gtgggtgacg aaccgataat 3670981 agtgaagcga ttcttcgttg aattcaatct taaaatggta ttttacaata ctcaaaatct 3671041 cttgcatgac ttttgtaatg ttgataatat tgggcatctc ttcattcagc tcggcattta 3671101 caatatgcag agcaataaag cctgcttcat cctctggcag agacacacca gtcttgtttt 3671161 ttaccataac caacgcttct ttgccgatcg caaattcgtc tttgtagagc cgttttgttt 3671221 cccacagcaa ggcgtttttg atatcaagcc ctttctggtt gcgctggatg gcaaagttaa 3671281 tatggtcggt cagcgacaca tagatgctgt cgttgagctt tttgccgagc tgtaattttg 3671341 cgtagctgat aatctcttcg gatacttcca tacactcgat cggtatatca tacaaaaggg 3671401 ttttgaactt ttctgataca tccttgttat cgagcgtgaa cactttctca atgcgggctt 3671461 catcgacatc atcgccggac tttttctgaa acgcgagccc cctgcccatg acgaccaatt 3671521 ctttcccctg ttcattgacc acgctgatca cattattgtt gatcaccttc gcaattttca 3671581 tggcatgtcc ctccaaatct actaagaaca gactatatct tgattgtaca ttctttttgt 3671641 actaggtcaa tatcatcagg gaaagacgga agctggtcag tacaattcac tccgtacctg 3671701 ctgcccgggc tgtttttgaa gcagcgcctc cagatggcgt tcaaatgatg ccttgtcagc 3671761 tttctgcttt ttgacaatgc tgttcatgat tttaatgctt tcagcactgt attgtgtata 3671821 ttgttttttc agctgatcca gctgctgtct tgtcttcttc gcgtttttcg gtgtgacttg 3671881 gttgatgagt ttgatcatac tgtctgcggt ctcaaaaaaa ccggctctat tttctgtcag 3671941 ctgctgaatt tcgatgcggc tcatatcttg attacgcgtt ttttgaagca aggcaaccgc 3672001 ctcgctgttt tgttttttga gcgatttgtt ctcaagctta atcgattcga gattctcctt 3672061 cgcaatgtct gcttcttctt cagtcatgct gattcgcacg aagtattctg gattgccgat 3672121 tccataatca aatgcttcgc tcacttgtat catggaactg aacacaatgg ccagctgcct 3672181 gtcgcttgcg agggcttgga aatcctgctt tttcttactg ctcatcggtt tggctgcggt 3672241 ttgttttact gtcttttgat cacagtctgc gaacatctga gcctcacctt cactttcgca 3672301 tgcgctcatc acaagaactg tgaccagcag gcttatacac aagcctattc gcctcatgct 3672361 ctgtctcctc tctgctgaat cccttctgga aaataccata aaatatagtt aaatggtacc 3672421 agatgcacct aaccccagca ataaatcaaa agtatgattt gaagcgaaaa aacataaata 3672481 ttttgtaaaa attgacgtgc attccattct tttcaggccc atttctcgta caatagaagt 3672541 atcgttaccg gagaggggct ctgatgatga aacgttttac gaaacaagaa aacagctggg 3672601 tgttatatga ctgggcaaat tcagcttact caattgtcgt gaccaccgcg gtatttccgt 3672661 tattttataa atcagcagct gcggaaagcg gtgtcagcgc cgctcaatcg actgcctatc 3672721 tgggctatac cattgcgatt tcaacgttta ttcttgcgat gctcggccct attttaggca 3672781 caatcgccga ctatgaaggg tgcaagaaaa agttcttcgg tttctttgtg tcagccggtg 3672841 tcgccagcac cgcgatgctc gcctttatcc ctagtgaaca ttggctgcta ttgttgctgt 3672901 tttatacggt atcggctatc ggtttttccg gcgccaatgt gttttatgat gcctttctcg 3672961 tggacgtcac gcctgagaag cggatgaatc tcgtctcggc acggggtttt ggcttaggat 3673021 acattggaag cacgattcca tttatcatca gtattgctgt catcctgctc gcacaagcag 3673081 agactattcc agtgtctgta tcggccgcaa gccagctgtc cttcttcata acggctgcct 3673141 ggtgggggct gttcaccatc ccaatgatta aacatgtcca tcaacgctat tacatcaaaa 3673201 aagaacctca tattgtcatc aacagcttta agcggctcgg ccaaacgatg aaacggatca 3673261 ggcaataccg ggcacttttc ctcttcttgc tcgcttattt cttttatatc gacggagtcg 3673321 gcacgattat tacgatgtcg acatcctatg gatcagattt agggatcggc tcctcaagcc 3673381 ttctgatcat cctatttgtc acccaggtag tcgccgcgcc gttttcgatt atatacggaa 3673441 aactggcaga acgcttcacg gggaagacca tgctgtacgt cgggatcgtc atttatatga 3673501 tcgtctgcgt gtatgcctat tttatggaga caacgcttga tttctggata ctggctatgc 3673561 ttgtcgccac ctcgcaaggc ggtattcaag ccctaagccg ttcctatttc gccaagcttg 3673621 tgccaaagcg ccacgccaat gaattctttg gcttctacaa catttttgga aaattcgcct 3673681 caattatggg gccgctgctc attgccgtta ccgcccagct gaccggtaaa tcctcgactg 3673741 cggtgttcag cctgatcatt ttgtttgtga ttggtattgt gattcttgcc tttgttcccg 3673801 aggaaaccag cacagatgtc agccagcagc aaaatgacct gcccctttaa ctgggagcag 3673861 gtcattcatc atttattcgc tttattcacc ttcagctgtt tccctttgac ggttgtgttc 3673921 ttcatcactt tgagaacatg agggccttta ccatttaaaa tctcaacgta tgaggcgtta 3673981 tccatgatcg tgatgatgcc gatgtcgtca gctgacacac cgtcaatttt ggcaatcgtt 3674041 cctacaaaat caacggctct gattttcttt ttctttccgc cgttaaaata cagcttcata 3674101 atgtctttat tcagctcttc gcttttgtcc tttttgcttt ccggacggtc attcagttta 3674161 gctagaaatt ctggtttctt ccttgccact tcctcttgag aaggtgcttc tattttttgg 3674221 atttcaaatc cgatatattc ttcaatgtcg gctaaaaacc gtttttcgaa ggccgtgaca 3674281 aacgaaatgg cctttccttt gttccctgcg cgtcccgttc ggcccgtgcg gtggacatag 3674341 ctttcttttt caagcggcag atcatagttg atgacaaggg agatattttc aatatcaatc 3674401 ccgcgcgcgg cgacatccgt cgccactaag taacggtact cgccacgttt aaattcattc 3674461 atgacgtcga atcggtcttc ctgaatcatt ccgccgtgaa ttttatcgca tggatatccc 3674521 aagtcatcca attcatcggt cagctgattg acgtgctcct tcgttcggca gaaaatgatg 3674581 cagctgtcgg gattctccgt catcagcaca tctttcagca atgaaaactt attctcttct 3674641 cttacttgaa tcaccgcatg ttcaatattt cttgtggtta ggccggccgc tttgacctcg 3674701 atatgctcgg ggttttgcat atattgacgg ctcagcttct cgatatcctg cggaagcgtc 3674761 gctgaaaaca gcatcgtcgt acgctcagtc ggcagatgct tgataatcgc ctccacctgc 3674821 tcaatgaagc ccatattcag catctcatcc gcttcatcaa tgaccaaata agagagacga 3674881 tccaacggca gcgtgccttt ttcgatatga tccagaacac gtcccggcgt gccgacaaca 3674941 atgtggcttt tttgcttaag ctcagctttt tgtttatcaa aggaggattt tccaaatacg 3675001 gctgtcgctt tgatccgttt aaatcgtccg atgttcgtga tatcttcctt tacttgcacc 3675061 gcaagctcac gggtcggtgt taaaataagc gcctgcggct tgttttcatc ccaattcgcc 3675121 agctcacaga gaggaatccc gaacgaagcc gttttcccgc ttcctgtctg tgatttgacg 3675181 acaagatcct ttcgttcaag ggcagcgggg atcacactct gctgcacctt ggtcggttct 3675241 gtatatccca gtccttccaa tgctcgtaaa atgtcatgac tgatttgata gtttttaaaa 3675301 tgactcatgt ataaactcct gtctcttgca gatgttctca ttatactcta attgaccaag 3675361 gcatatgtgt tttgtcgaaa aatgatgtat taaaagccag cgattccctg gcgttttagc 3675421 tcctgaacag ccaatcgcgc cagtgcgtcg gcccccgcgc gattcgggtg cagcgtatct 3675481 ccatccatat aaagcccgag tgttctttcc ggaccgatcg atgtaaagta tgccgagctg 3675541 aggacattta agtcaatgag atatgttttt tcctcttcgg ccaaagctaa aatagaggcc 3675601 ctgtaccatc tgtttacaga cgaatggatg ccttcagaag taaaatcggt tgcccggccc 3675661 tgaggcgttg ataggatgac gtccgctcct ttcgctttta cctgacgaat catatcacgc 3675721 atcacctctt taaactccgc ttcagattct ttatgcttcg gatttgtgtc attaatgcca 3675781 agctgcaaca taaaataatc tccgggttta atatacttca gaatcgcctc aagctgtcca 3675841 tcatttctga accctctcgc gatctgcccg ccagacgcca tgtttctcac ttgaaaggtg 3675901 tgtttatcga tatagtgagg cagcatctgc ccccagcccg cctgcttgct gctgttgagc 3675961 ggataataat tgcacaccgt cgagtcgccg ccgacataaa tggttcgatt cgttaccggc 3676021 tgatcagaca atttctttat tttcaaggcg ctgagcgtaa aagcggtgcc tgcctttccc 3676081 tctgtcacca gcagattcag ctgcccgtcg gtgacgggaa tttggaacgt atcctccgcg 3676141 ccatcccctg tcatattgat gacctgaaac acgccctccg ctgccacact ggcccttgcc 3676201 gtattgccaa gcgtcacctt cacctcataa aggccattcg ggagatcaac attaaacgtg 3676261 ttattgcttt tcgtcccata cgctaaaaac tgaaccgcat cactcttcac accagccccg 3676321 gatgccgcca catccctcat attctccggt gtttgaaaac cgtagccctt tgaccggtca 3676381 taccgatcag acgccctgac accaatataa ccaggctcca tcgaaccgct tccaaagtca 3676441 aactgataca ccttcggctc cgccgccttc acattctcaa tcccgccaaa acacagcatc 3676501 agcatcatca caaaaaccgc tgccatccat tttttcatca agactccccc tctatgaaaa 3676561 cgaatacatt aatgcatact cggtgattgt ttctttatga tgactgaatt aagaaaaaaa 3676621 ttgcgttgag gaataaaaat gaggggagag tctcaagaag gggaaaatca gtgtgacttc 3676681 ttgtcacact tgatcacatc ccaacctccg caatagaagc ttatttggtt ttcttcgtca 3676741 tacacataat aacggagtct ttcccattga tcgtcagtcg gtacaatctc caatgcaacc 3676801 gaatcgatgg attcaaggtc atccagcttt gatgcactaa tgttttcaaa ccgcaattga 3676861 atgtcacagg tttgagcaga tcgttttcat tcaaacacag gaatatgaat ataacgatca 3676921 tcttctttca tatagaaaga aaactcgttt aatgtaaatg gacctgtatc ctcatcagaa 3676981 agatgctgtt tcaatttctc gtattgtgtg atattcaaat gaattccctc tatttatatg 3677041 attcaccgcc aatcatataa atgtccacag catcgtattc aaaccatatg atccgttcgc 3677101 ctgagtccgt taggcattgg agcttccctt ctgaaaaata gcttttatcc ggttgaggat 3677161 cagtgatcag aaaaacatca tcattgatgg aagctagcag aaagagaaaa tctgcaatat 3677221 cccggtctgc ttcctgtaat atggattgga aatggaattc ccttttggcc agcttcgtca 3677281 ccttgtaagc atgaccttca aaatactcgg acaggtcttc tataaatgaa ccagtcgtta 3677341 ttacctgtat catgattcga tcgtaggcaa gccctgccca aaaacgataa aacgactctg 3677401 catcttcaag ttcgcatgcc ataacggttt ggtcaggctt aagctcgatc atgtccaaat 3677461 tgccaatact gcttatagag gttatttcca taaaatcttc cccttatcag ttggatagcg 3677521 caacgcaaat ctcttgtctg acttgttcat acaagagaat gtgatgatac agatccttat 3677581 cgtttttgat catatccgga agtatgtcag gatacagctc aaaaaagctt ttctccaacg 3677641 aacgccgctg atgccggggt atccttttat tcgccagcac ataatccaaa ctgccagcaa 3677701 caagcataaa aaactcatag atttccgctt caaagccgta caattcatca gggtactgct 3677761 tttcttcaag ctctcgctgt ctttttctca gtttttgaag cacgttgatc ctctcccttc 3677821 cgcaataatc tcatttattt cgaaacagaa taggcggatc attatctatc gcctccaaca 3677881 gctcttcacc aaacacagtg attgcacatt tccacgggtc tcccaaaagt ccccaggaga 3677941 agtcctgatg aaaaaagaaa taatagtctc catttggaaa tacgggaaca ggccattcgc 3678001 caaattcatc cttaggcatt gcctgatgag gactaaaggt atatccgtca tgctgccaat 3678061 ctagtgcgta cattacatcg ttctttccag tacctaattg aaatgctttt aaaatagaag 3678121 tctctaaatc acttagcact ccgctcacat cattatgacc agctttactg ctcatcgcgc 3678181 ttgagatatc aaacactcga tatggatcag gcgggatgat gtgatgacat ctgcttccgg 3678241 gcttccattt tatgatcttg ttcacttctg accagatgcg gtcttgtttt gtctgactta 3678301 aagcgcgcca attcatcata atctcatccc tacaccttat tggatatcct gcttataaac 3678361 accagaagag gccactgcgt aaacagcgta acttgtcagt ttcagctgtt gaacatctag 3678421 gccttcaccg ttcgaatcac agcatgttat ctcttccatc tcttgactca catcggcaga 3678481 aatcaaataa agagacgact taaggtctgc actgtaacaa ttgaacgtcc caaccaaaaa 3678541 accttcttcg gatatcgcga gctgatcaaa tgcttctgag tccggctctt tatccgacag 3678601 aatccacacc cgtctcacga ccgtttcatc aaatgcggca atgactgcat ctccgtaata 3678661 cagcatataa atcaagccgt ttttttctgc aagtccataa caatcatcta cagcaggcgc 3678721 atccatttct tcaagctttc tatcaatgtg tatttccttc tgctgaccat ctaacgtaaa 3678781 acaccacaca ctatggccgt tgggattctc atcatgataa atcccttcat cacataaacc 3678841 gacccaaagc tgttgtttct aatccaaaag acagcaggaa acccctgaag gcaagtgaaa 3678901 aacacttttc acccttccct cttctgaaaa aacctttacc ttcggctcgt acgattcgta 3678961 ataaacgaag acatagccat ctgcacattg ttgaaagagc agaatatcac tgtatgaaat 3679021 ctgctctttc actctaaaat cccgaacatc accggaagga tcatagattg taatggtgat 3679081 accacctttc aacccttttc caatgtagac acgcccctgt ggatcagcat ggaaaaaaca 3679141 atcttgggtg ttctcgttga tgattttatt caattttaat tttttcattg gttatgctcc 3679201 taggttcgaa atgaaatgat aagaataaac catttattag ctattagtaa cggacaacct 3679261 agtttcatta atcgttttgg gataaatcta ctttccaatt cagccttaaa tcatttagtg 3679321 tttaattggt atgcataaaa cgattgatca tcaaagcgaa ctgtttcagc ttctatagca 3679381 atcagcattc tgttcatgtc aataagaaag ttagcatttg attgatactc cggaattata 3679441 gaatttgata gattcccgat tccttctgga tgataactca tctcaaatac ttgccaattg 3679501 tattcttccg gatctatttt ttccaatctc atgtcgccaa catctgcact ataataagcg 3679561 gatgccacat tttgaaatga aattttatgc gtatattcac cttcatcttc aaaaacctta 3679621 atatcaagtg agagttcttt tttaaacaca ttaaaatcta aatgaaggac actgcacccc 3679681 ttatctatat aatcaaccca ttcattaatc gtttgataca ttgtcatccc ctgcctcttt 3679741 ttaaacaata acgccttgcc accaagcaga aaacaaatta ctccgtatat tgtttgatcc 3679801 aatcatttaa atcatctgtt gaatgcaaat aagtttctga tgaatctttc aaatcaatcc 3679861 cacttagaag gattaacata tcccagactc tatcgtcttc tacttcgggg tcatccgcat 3679921 aaacataagt tccagcccaa tccgacactt cttctcttgt tgtttgtcca tttaagacac 3679981 ttttgatttt atttatgcat tctattagat ttgtctcgct caatttgatc accacgtatt 3680041 caagtactaa atgatttttt attagtatgc aaagcaccgt actgatattt agatattgaa 3680101 gctttttccg taaaagatat gttccaaaag gtttccaatc taccaataaa caagctcaca 3680161 tccgtattcc gtgtgcaata tacataaacc aaactggcac ttaggctcaa ccaaaataaa 3680221 actatgattg agaatccctt catcgaactc aatacactcc aataagcagt caaggtgctc 3680281 gagacatttt ccaaaagaac aaactaacgc accaatttcg ctgctgtatt gatgaaacag 3680341 cagaacgtcc cggtcatcgt aagcaacata tgactgagat attttccaga tcagctgttt 3680401 cgcttccgtt ttttcgaggg catcaacctc acgggtgttg gctggtattg aatttgataa 3680461 aaccagctca agcaattgcc tgctttgcgc cagatcagca aaacgataag tgaagcctct 3680521 ttctgcacaa gggactagtt tttctttgat ttcgctcatc aataaacgtc ttttattctc 3680581 ggcgagtttt tcgatcaatc ttttttgcat gagccgcatt ccctccgctg tcaatttctc 3680641 aacttctttt aaattgattc atcattctct tgttttcgtt gtcgttcatg tttagatttg 3680701 ttctaaaaaa gcttgtatcg cttatcgata caagctttat cttcaactgc ttaaaactca 3680761 cccagtgggc ttttcacaaa acgctgggaa cctttttggc aaatcctctt catcccaatc 3680821 aattctatat ttttagattc ttttgtcata caaataagag aggatggtaa catctcttat 3680881 ttaatgttcc atcaataaat gccccatttt tatccaatgc agaaattatt tataattaag 3680941 gaagtttaga aggatttttt gtattttcaa gatttaattt taaagcggtc acaaaagact 3681001 ctagcttttc ttcattacaa ttaatttcga acaagttgga gttcgactta ctttctttat 3681061 aatcatcaaa tataatttta atcttaattc tgtaatttcc gttttcttga tcaatactaa 3681121 gaaataagaa tggttcaata gtctctaaac tgatactgtc ttgatttcct tttatcatag 3681181 tttcgatccc agatatcaac accttatatt cactttctaa taaaacagca gaaaaatcgc 3681241 gaacgacggc tttcttattt tccaacaatt caaatacaga taaaataaat ggatcatcgt 3681301 ccaactcttg ataccttctc ggtgttaatt caagttctat acaatcatct tttattttgg 3681361 ccatatttcc tcctcattta aagtttaagt gagggtagtt gtcatccccc cctcgcttaa 3681421 ccttattaac gccttctctt agatttattt ccttttccgt gtgtatggaa tacgtgttta 3681481 gaacccttag ctcttgaact tccataagct gtgattactt tacccctttt atttaaaaca 3681541 actgtagctt tttttccaac atatttcgtt gccccattag gttgttttat tactttttta 3681601 gggcttcgca cagcattcag tttggccctt aaattgactc cacggcctcc atttcttcct 3681661 atagattgat taagtccatg tcttgtatga cctgtgattt taactgcctt cttcgtaaac 3681721 ttataggcgc gactagcacc cttaaatatc ttcccaggac caaaattaga agcagctgcc 3681781 caagcagcac ctttccatcc tttacctgat ttatatgcct tatatccatc ataggctgca 3681841 aatccggcat ttaccacaag ccatacccaa tgcccgtccg gatcaacatt catcactggg 3681901 ttattatttc cataagcata cccattctga tccaatgaat ctccgtcgct gcccgggtct 3681961 gggtcgagcg ataggaacac gccgtttctt ggctcgtagt agcgggccat gagatagtac 3682021 aggccggttt cttcgtcgta ttggtagcct gcgtagcggt agcgattgtc ttttacttcg 3682081 tcgcttgctt cggtttttgt tggatttccc catgcgtcgt attgatactt ggcaacggtt 3682141 tttccagtgc tgtctgagat cgcgatgatg tcgccgtgag cgttgtagtg atagaaatat 3682201 ttcttaccat tttctgtgta ggataacagc tggccgctgt ctccgtacgt gtatgatttt 3682261 gtgacgttgt tgtccgcgtc tgtttcatac aagacgttca agctgtctcc gtcgtagaag 3682321 tagttcgtga cttttccgtt gacggttttt tggattctgt ttcctttttc gtcatactta 3682381 tatgttgcga atggcttgtc ttcgcctttt ttggtaacgg cggtcaggtt atcttctgca 3682441 tcccacgtat atgtgaattt gccgtcggat gtgcggttgc cgtttttatc gtaagagatg 3682501 ctttcatcat tgacttttgt cagctggttc atgatgttga aggaagcgtt caccgttttg 3682561 cttgagccgt cttttatagt tgtaacggtt ttccggtttc cgaatccatc atatgtgtat 3682621 tcaataacag taccgtcttc atgggtttct ttgacaagct gattcagctt cccatactca 3682681 tattgcacct tgccgcttgc tgagctgttt atcgttgtgc ggttgccgtt ggcatcatat 3682741 tcatagcttt ccgtcagaat gtctccgccg tttttgtcac cgatatgcag cgagcttaca 3682801 aggtttcttt cgtcatatga aaaacttgtt ccgccgccgt tgcccgtaat aaaggtttgg 3682861 acgtttccat tttcatcata atcaaatgaa tatgaggatg tactgtcttt catctcaatc 3682921 atttgatcca gcttgttata cgtaaattga ttcgttcctt tttggtcccc atgaatccac 3682981 gagaaggttt tcagcttatc ggagtcacta ggatatgtcc aagtttggct gccgccgcgg 3683041 tctgtcagtt cggttaaacg gtttttgttg tcaaatgtcc gtttctttgt ggtgttctgc 3683101 tctttattga cgaccgacgt ttcatttcca tttttgtcat acgtgaaaat gtacttttct 3683161 gtaccgttat acgactttga tttcacccgg tctgttccat cataagaaag agacacttcg 3683221 ttgccatttg gtgaaatggt tttggtcagg ttgctgttgg catcatattc gcttgctaac 3683281 acattgccga gagggtcagt tgttttgaca agcttgccca tgacatcata ttcgaattta 3683341 taggtttgat ctgctcctgc ccggatggtt ttgcttacct cattgccttc cttatcatag 3683401 ctgtgaagga tagacgtgcc gttagagagc gtcatgtttg tcaattggtc tgcctgatca 3683461 tacgtatagg ttgttttttc accttttgca tctgtttcag acgttttctt accagtttca 3683521 tcgtaatcag ttgaagtggc gtaacctagt tcgtcctctt ccttggtcac atagttgcca 3683581 ttactgtcat acgtgctttt agtcagaagg cttccttcaa tcaaacggat atcatcaaac 3683641 cagactgtgc ctgtcgcact cttttggaac agaatactga tatcgacttt attgatcggc 3683701 tttgttttag ggatgacgac agctgctcgg ttccattcct gtgttccaga agggaatttc 3683761 gcattgtaga tgcctgtgct gccgtcagcg taagtgacat tcgcctgcag agaatagtct 3683821 ttttcatctg taaatttgac gctgcttgct ttcgacattc ctgtcagtgt gagataaacc 3683881 ggtttgtcat ttgcgctttg ccctaagaca acggtttgtt ttgttactga tccggcttgg 3683941 gacgcactgg tccgggcagc ttttaatgat acatcatcat taaagccttc ttcagaatca 3684001 acggatgctc cgcttacatt ccagttttcc gttgctgatg tgaagctgct gttttgaact 3684061 gggttatagc ttgatgatac ttcgcctttt tccagctgga cttcatcaaa ccatgctttt 3684121 cctttgccat ctttatcttt atgatcgact tccatataca caacagcttt gcctgcattc 3684181 gctggagtcg taaaagtgat ttgccgtttt gtccagtcat tttttccggc taatgcactg 3684241 tattcattgt gaatccattg aattcgtttt tgatctttgt ctcgcaaatc aatgttaaaa 3684301 taggctcttg atttcgcaag atctgttttg attttcccgc ttaatgtata ggttgtattc 3684361 ggctccagct caactgtttg tgttgctgac gaatacccat gatctgttcc ggcagacgtt 3684421 gattggctca agacctccaa tgcctttgat ccggaaagaa ctccgctttt atcggcgatg 3684481 actgaaattt tgccgctgtc tttagaggca gtcagattcc agccggattt ttgagcttca 3684541 aagcttccat ctttcaaaat attagttgaa gctgataaat ctttgctcga ttgaatctgg 3684601 tttccatatt tatcataaac agctgctgac gatgattttc cgctctgatc ggtttcggat 3684661 acagcatcca gtccgtcata agcaatatcc gtgacattgc cctcggtatc cttcatcttt 3684721 gtgacatcgt tgtttttgtt gtattcgtat gtctcagttc catatgcatc tttaaccgac 3684781 gtaacgttgc catctttgtc atattgatag ctttccgttg cttttccggt gccgacgtca 3684841 tttggatcta catcttctac aacattgttg ccttcatact ttgtattcgt tgtaattttt 3684901 aacccttccg catcatcaat gacctgaatc ggatttcccg cttcattata gccatactgt 3684961 actttccggc catttggctg tgtcatgaga agcgtctttt tatcagcatc atagctgtag 3685021 acatatgttt cttttttagc gttgatcgct ttttcgagac ggtgaccgct atactgatat 3685081 tcggtaaaga caggctttgc ttcggtactg ttagctgaat attgtttgac aaggcgccct 3685141 tcactatcgt agtcatagct tgtgacagtc ccgtctgtat ctgtaacctt cttcagcaaa 3685201 tcattctcat atgagtaggt gactttctta ttcttaggtc ctgtgatgga cgtcacatgg 3685261 ccgttttcat cataggtaaa tgtaagcttg cggcctgatg catctgtaat ggcggtcagt 3685321 tgatttttgt cattgtaagt atagacagtt gcattgttat ggccatccac taccttttgg 3685381 agtttgccgc cttttttatt gaaataagcg ttggtttgat cctttgtttt taatatgaac 3685441 tgatcagctg tttctgttaa ttcaagatat acaccggtcg gcggctgata cgtgccatcg 3685501 gcttttttcg tgaatcgatg tgtcgtagcg tcttcatcga tatacattgc cccgccatcc 3685561 gttgagatga cagatgtttc tgcatcagca taccagcctt gtccaaataa gtgatcagag 3685621 ctgtcaagac tgttgtaggt tctcgataag ccaagtcccg gaccgcgtcc atcaattgac 3685681 aaatcttctt cattcacaat gacattgcct gtcgcaccat ttaactggcc gcttgggata 3685741 tcaatgatag accagtactc ttctgtacct aggaattctg cgccttcatg gaacgttggg 3685801 ttaaagggcg ccgttggaat cgtttcacca ttcgcatcat aggcgacaag cgtgaaagaa 3685861 taattcttct tccctttgta attcccattt gcattgttat agacaggtga tggatcgagg 3685921 gctaattccc cgccttttcc atctgtatga agcttatagc ttccggcttt gatttcctca 3685981 gaagtcggcc agatgttttt attttgggtt gtccaatgat cagcatcacc aacatcaaag 3686041 gactgatatt ctttaccgtt gtaaatgtta actttatagc ccttcgcatt ttgaaccttt 3686101 tcccatatca aattcacata acccgtttga ctcgattttg tatttgtata caaatagcca 3686161 gttacattct ttggcctagc gatatcagga agtgccgggg tagcagccgg ggatgcaatg 3686221 gcttcgccgt ctttgttgta tgcgataatt ttaaacgagt aatttctttt ggctccatct 3686281 cccccggcgt ttttataggt tggtccggga ttgatcggca gctctgctcc gcttccgtcc 3686341 tttaggtgaa gagcatattt tcccgccttg atttctgcac ttgtcggcca gatctttttc 3686401 ccttttgtgg tccaagacgt ctgatttccg agatcaagtg tctcaaagcc tttcccattg 3686461 aacacctgaa ccttatagcc ggttgcaccg gatacagctt tccaagaaag gtcgaagtat 3686521 cctgtggcat tcccattatt gtagcccttt gctgacggtg cttgtgcttt tcctacatta 3686581 gggataacgg gctttgccgg tgcggacatc gctccttcac cttggtcaaa tatcgcactg 3686641 acgccaatcc aatagttttt gcttgtagca tagcttccgc cggaattctt atagaccggg 3686701 gatggatcta atgccaattc agctccatcc ttgccgtcca gatgcagttt atatctcttg 3686761 gaggcaattt ctgcgctcgt aggccagatt tttttacctt ttgtgctcca cgacgtgacg 3686821 ttgcctgcag aaatcgcttg atattcctta ccattgtaaa tccatacctt atatcctttt 3686881 gcgccttcaa cctttttcca gctgatatcg aaataaccag tggaatcgcc gttgtgatag 3686941 gctttgattg taggtgtgtt tccctttgga atggtatacg tcacttcaat atatggttta 3687001 ttggcggagt tcgctgaaga aattagtttt ttccaatatt ccttgccgtt tccgtttgta 3687061 tgaagcttaa atccatagtt ggccccgccg gagttccatg actttacagc agcggtcaca 3687121 tcataactcg cccactgtcc tttatggacg tcggcttttc cgatattttt agatgccggt 3687181 ttggtgttcc atgtcacttt tgcattatca taattgctgt tgaccgtatc cagccaaagg 3687241 ccggttgcct ttgttccata ataggaatgg gctacgtatg tttttaatgt agctttagtg 3687301 acagtcatat tttgaattgg ctttaggttg ttaaatttca tgaacgcata gtttgtgcct 3687361 gttgttttgt cataatagcc cgttttcagt acataggcct ttaaattagc atcccatttt 3687421 tgtgaggagg ccgaatagtt cgtcgtcggg taggcactca tgacaaacgt atccgatgaa 3687481 acagataaag aagttgacgg gtcgatagat actggatata cgcgttctgg gtctttcagc 3687541 cagttctcgt ctgccgtaag atgaagcaaa tacccttctt cattcttttc cagcttatag 3687601 ctgactttgt ctgaccgttc aacctcgccg gaaagctcat ctagttttga atccgtcata 3687661 aaaggcttag gcacagaaaa aacaactttt cctttttcat cagaaaaatc aatggatcca 3687721 tcctcttgtt ctttagcctg caaatcggtt tttaactgaa atgtaaatgt gttgtatcca 3687781 ttatactgat gaaggactaa atcttctttt atgttttcat tgaatgtgaa agtctgaaga 3687841 tcaatattcg gaaacacatc cggatacaca atctcattac tgtcagtctt ataatctgct 3687901 gaggtatctt tcggagtaag tgaagtttta ttcgggcctt tcgcttctgc tagtgaatat 3687961 gtaaccttat ggtcattatg ctcaaaagtc gcataaagcc cgttcttcat ttgcttttga 3688021 aaatctgaat tcaaaatagc gttctctgtc tcgacttgtt tgcttgtcga ctcttttaac 3688081 tcaggagaaa tgtcttccca gtcggcatcc ggtgtttcct ttgtatgaat aggatcaagg 3688141 tatacttcct gtttatagac accgtcacct tcataataga gttttgtatt ttctgttctt 3688201 tcagaggtga tctcaccctc tttgtttata tcttttggat caaaaggtac agcttcctca 3688261 gtttgttctt tctgaagagt ttcttctgga tcatcggcag caatacggtt tccattctct 3688321 tcttctgtag attttgctag tacatcggct ggcactaatg aaatcattaa agccaacact 3688381 aaaaatgctg caatgaacct tttaaagttt cgcctctttc tttttttcat ttcctctctc 3688441 cttttgtaat aaaagtaata tttactcaat aatcttaact agactgaaat atcattacaa 3688501 tatttttcta gaaaatttat cttattttaa ggattagcga gagtcaattg acctaaaaca 3688561 aaaaaaggcc gcataggcct ttttacattt tttattgtat ttgttcaata tccgtaccct 3688621 cagctgtcac attcgccttc ccctgcctcc tgacaagcgt caaggccatg cccgcaaaga 3688681 tcattacgat gccaagcgtt tgatagaggt cagggcggaa gcctgtgaag acggtatcga 3688741 gcacgatcgc gacagcgggg tcgagaaata caatgattga aataaatttc gttgataaaa 3688801 atcgtaaact gtcaaaaaac agcaaatata caatacccgt atggatgatg ccggtagata 3688861 ccaccataat ccagtttccc tgagataggt ccgcaaaagc gccaaagtga ataaacggaa 3688921 tcaggatgat aacccctaaa cctgtctgca agaaggtggt cgtgtaagga ctgagattgt 3688981 gaatgccttt tcccaataaa gtggtgaacg cataaaacag tgcggcgaga actgcccata 3689041 tgatccctga tcccatcagc tgtgtcaatg atgtgctgcc gttaatcccg gaaatcagcg 3689101 cagtcccaag aaagcagatg ataatggagc tgacggagat cacatttaat ttctctctgt 3689161 agaagaagct ccccagaaga agaacaagca ccggcgctag atgataaaca gagatggcaa 3689221 ttgtaacgga cgtttcttca aaagacttaa ataagaacac ccagttgaat acaagaaaga 3689281 aaccgcacgc caatgtttgc agcacgtctc tcttgctcca tttttcagtt ttatactggc 3689341 cggacgccag ccagcaaaag cctaaaaaca gcgtcgcgca aaggcagcgg acaaagacca 3689401 attcaaatga cggcagattg gtatgctctg agaaaaagcc gatggagccg aaaatcacca 3689461 tagagatgac cattttgatt acggctgttg atttttgttt tgacgatatg gaaggatcct 3689521 gttgcatcaa acgtattcta cctccaatac tgcatagcat aaactgtttt ttgtgaattc 3689581 agaaatctac acatagaatt cctctttttt acatgtagat attataacac ttctattcta 3689641 aataaaaaaa agcgcccaag ggcgcttttt ttacaaatct atcgaacaat caaaaccggg 3689701 catgttgata attgagacac tttatggctg acgcttccaa gcatcatttc tttcaggccg 3689761 ctgatccccc ggctgccaac tacaatcagg ctgacgcctt tctcttttgc gtgatttagt 3689821 atctcatgcg ccggctcgcc attcgcgtaa atggtttcag cttgaacgcc tttttcggct 3689881 gctttttctt ttgcattctc aaggattttc aggccctctt ttttaacctc gttcctgatt 3689941 tcatcaataa agtgttcagg cacatagaca attcccgtca gagaagaagt cgtgacgacg 3690001 gcttctctcc ccacatgaag aatgcttagt tccgcttgtt gctcttttgc caaatgcact 3690061 gcggcatcaa gcgcttttgc actcatgtct gatccgtcaa tcgctactaa cattttgtta 3690121 aacatgctct tcccgccttt cggactgtgg gtggttcatc tttctctttt attgtccgcc 3690181 tgcatttcgt tattgtcaat tgaagcgcat gagttttcaa aaaattgtca gagactctct 3690241 ccgtttgtgg cgataacctg ctgataccag ttgaagcttt ttttcttgat gcggttaaat 3690301 gttccatttc cttcattgtc ccggtctaca taaatgaagc cgtagcgctt tttcatttcc 3690361 gcagtagatg cgctgacaag gtcaattggc ccccatgatg tgtatccgat taattcaacg 3690421 ccgtccgcaa tggcttcgcg cgcttcaatt aaatgatcac gcagatagtt gattctgtaa 3690481 tcgtcctgaa tcgtgccgtc ctcttcaacc ttgtctacag cgccaaggcc gttttcaacg 3690541 atgaacagcg gcttctggta acggtcgtat aaggtgttga gcgtgatgcg caagcctttc 3690601 ggatcaatct gccagcccca ttctgatgat ttgaggtaag ggtttttgac tccgcccagc 3690661 aggttgcccc ctgattttgc aagctcttcc ggatctgtgc tcgccgccat cgacatgtag 3690721 tagctaaatc caatataatc caccgtatgt tctttcaaga gctcttcatc gccttcagcc 3690781 atttcaattt caatattgtt ttctgccaga tagcgtttca tatatcccgg gtatgcgcct 3690841 cttgcctgaa catctgagaa gaaaagtgtt ttgcgctcat tctccattgc cgcgaagaca 3690901 tcctccggct tagaagtcat cggataggtt gtcgttgccg ctatcataca gccgattttc 3690961 gaatcaggaa tgatgtcgtg acccgctttg acagcaagag cactggccac aaattggtgg 3691021 tgtgccgcct ggtacatcgc gtttaatttg ttttctcctt cttcaaaaac aagaccgcct 3691081 ccggtaaatg gcgcatggag cactacgtta atttcattaa acgtcatcca atacttcact 3691141 ttgtgttgat agcgtttgaa aaccgttttg gcatagcgtt cataaaactc tatgactttg 3691201 cgattcttcc agccgccata atttttcact aaaccgagcg gcatctcata atgagagatg 3691261 gttacgacag gctcaatatg atgctttaac agctcatcaa acagatcatc ataaaatctg 3691321 aggccttctt cattgggctc ctcttcatcg ccattcggaa aaattctcgt ccacgcaatc 3691381 gatgtgcgga acgccttaaa tcccatttct gcaaataagg cgatatcctc tttataacga 3691441 tgataaaagt caatcccgtt gtgatacaga ttcaaggaag tcattgattc atcaaatgga 3691501 gacatgatcc cgttcggcga tacgtcagct gtcgaaagcc ccttaccacc ctcgttataa 3691561 gcaccctcca cttggttggc agcaactgcg ccgccccata aaaatccttc tggaaatcgt 3691621 ttttcatttg aactcatatt gatcacccca ttagtttttt caagataaag caagcagcgc 3691681 ttcttttggc tgcactttac cgatctcttt caccggcgaa aacgaatatt ggtctgtgtt 3691741 ggtcacaatc accggggtaa tgacgtcata tcccgcggct ttgatttgct ccagatcaaa 3691801 ggacacgagc ggatctcccg gtgcgacctt gtcgccttct ttgatgtgag ccgtgaacca 3691861 ttgtccctcc agctttaccg tgtccaatcc aatgtgtatg agtatttcag ctccctgatc 3691921 actcgtaatg ccaattgcgt gttttgtttt aaaaatggtg gtaacgcttc cacgaacagg 3691981 cgaaacaact tctccttctt caggctcaat ggcaaatcct tttcccatga ccccagcaga 3692041 aaacactccg tctttgactt cacttaaggc tttcacttct cccttaatcg ggctgtgaat 3692101 gatctctctg ctgccttcat gcactgccgg ctgctggctg ccgtcagaag gcacatcctc 3692161 gaatccaagc aaatacgcag ctgctgttcc cgccgcaaac gcaatcacaa ggccgatcat 3692221 cgcgtaaata aacgttgggc cgataaagac agggatgctc ggcagacctg cattcccccc 3692281 gacgatatag gaagcaacac ccgtcatgcc gtaaaacgcg ccaccggctg caccgccaat 3692341 caaagcggcc gcaaacggct ttttcaatcg catattcacg ccgtacatcg caggttctgt 3692401 gatccccatc agcgccgtga tgcttgtggt aagcgcgagt gatttaaatt ttttgtttct 3692461 agagcgaagg aagacggcaa atgatgctcc cgcctgcccc atattcgcca aaaacatagc 3692521 cggcagtaaa taatcgtggc cgttttgagc gatgttgttg atcatgatcg gcacaaaggc 3692581 atagtgcatg cccgtcataa tgattaaaga gaatgtaccc gccagcaaaa tcattgccac 3692641 aagccctgca tgatcaaaca aataattgac cccagaagac aagtattctc ctaaaatagc 3692701 gccaagcgga ccgactgtaa tcaatgtcag cggcacgaca atcaatagcg tgaatgtcgg 3692761 aaccacaatc aatttgagag atgcgtgtgt aaaacggtca atccattttt ccacgtatga 3692821 agcaatccaa atcgacagca aaatcgggat gaccgttgac gaataagtgg cagcggttac 3692881 aggaagcccg ataaaggaaa tcggtttccc cgcaccgagc agggctgtca aatccggatg 3692941 caggatcgcc gccgcaatgg cagccgctac gtacggattg cttccgaatt ttctcgccgc 3693001 actcatcgct agcaggagcg gcaggaagta gaacgcaccg tcaccgacag ccgtcaaaat 3693061 gacatgaacc tggctcttct ccgccatcca gccaaacgtg actgccagcg ccacaagtcc 3693121 tttgatcatc cccgctcccg caatcgcagg cagaataggg gtaaacaccc cagaaatcac 3693181 atcaaagacc gcactcagca cattcttttt ctgagaggat gaaccagcgc tcttttcatc 3693241 actgagattg ctgtgccgca caatcgcctg atacaccttc ggcacatcgt ttccgataat 3693301 gatttgaaac tgctcgccgc tgatattggt gcccatcact ccaggcagct gctccagctg 3693361 actgcgatcc gccttcgcgt tgtcatgaag attaaaacgc agcctcgtca tgcagtggat 3693421 cacgcgctga acgttttctt caccgcctac gagttgtaat atgtccttcg ataatttatc 3693481 ataatccatg tgtatacctc ctttttatgg ggggactgct ggatgaaagg tggccgcctt 3693541 tcaccagctt tttttgtatc aaatgctgca tcacctccta aaagagaata aaaaaaccta 3693601 aatgacacag attgcgagag tctcctcctg cacctgcacc atttaggttt tgcctgcttt 3693661 cgcagtaaca atcctgacgg gtcgttttat ttgtttgtag gtatacttta gcactagatt 3693721 cgtgagatgt caacgctttc atttttggtg ttgactatcg tttctagaac aaaagtaatc 3693781 ataaagattt gaacttagta ttaacttcaa taaaaaatta ttgtaattaa aaaccttgaa 3693841 aggcattttt tccaatcaag gttatgaatc gttaccgttt aaattttttt aaagacttct 3693901 ttatctgtac tattacattc tttagccaat ctattggttc taaattaaac gcaggaagat 3693961 acacgccatc tgcgcaagat tgaatgtaat cgtttttctt attgtctgaa tgctcacttt 3694021 caataaaatc cgttaaaaag acaatagcat cctccaaata ttccttactt tcctctatta 3694081 ataactcttg tatagcgtca tcaggagttt caatatcttg atggaatgtt ccagctaaaa 3694141 actgaaaaac agggtccttc tgtttattga tcaataacat gtcatcttgc tcctttaagg 3694201 gagaggtaac gggataatgt taaaatcatt catcatctaa taaatcaaga taatactgat 3694261 cattctcttc tatttttctt aagaactcgg taagagaagt tgcaatttga atatcataat 3694321 agtaaatcgg atttttatta ttatcattta attcaattga cattaatgcc gattcactac 3694381 cttcaaaaaa tattaattta tcattctcaa actcatcata tatttctatg tcaggataaa 3694441 attcaaagtc atttatcctc aatcgaaagt ctcttacaga atatggatcc aaaatgcgat 3694501 tagtattaaa ctctgatcct ttaataaacc catagccaac ttctaaataa aaattcacta 3694561 attcactagg taattttaag tttaaatttt tttcaacctc ttcaatctca ctttgattca 3694621 ctggataaaa atcattttct ttgtttgatt ttataaaatt ataactcatt tttttttgcc 3694681 tcctttaaat aattcatttg ctggtgagcc tgtaccatga atcccagctt gatgctcgtt 3694741 aggaaatttt gctggatgca tattccacca ttcatgttct ccgccaaaag tattttcaat 3694801 tatatggtga gcatcatact tatccccttt ttttctaata attttacctg ttttttcaga 3694861 tacaacattt tccttataaa caggccattt ttgtccagtg ttttcttccc attcttttat 3694921 aactttattt tttactttat caaatttagt cctgtgtttt gcagtctcta ttggtgacat 3694981 ttttttatat tctttatttc ttaatgcttc ctttaattta tctatttgat ttttaggtaa 3695041 ttctctacct gtgcgttgtt ctatatctct agcatacttt tttattaaat cagaattaat 3695101 tttattagca gatccactta catcattcgc aattttccct ttatccttag caacgttttt 3695161 aacttccgaa gccttcttag cctttttccc attattaata agtttattaa tatctattaa 3695221 cttttctaac ttagctattt tggcaaatgg tactgagttt atggaggcaa caacacggtc 3695281 tttccctgtg actttttcgc ctgataccgg atctctgccc gtggctgctt taaatagatc 3695341 atacacgccg gtaagttcta cagccgtctc taaaattttc acatatccat tctcatccac 3695401 tttaatgtcc gaaagcgaga cgacaggttc aagcttcatg tcattaccag atatgtatac 3695461 attgtaaagt gtatcattat aaacgacttg cttaacctct gcatttgaga aatcagtttt 3695521 tatatgttct ctatgttcac tcgtattata cactttacca ttgataacga tgatattttt 3695581 acttaccttt ttagaatcac ccgttttgac aactgaatcc actttagact tttcattctc 3695641 ggctaatttc ttcagcatca tctccatcgg tgaatcatcc gcctgcttca tttgcgggtt 3695701 aatcgcgccg aagatttggt tgatgttttc ttcttcctgt gatttcagga tggagccgct 3695761 tttgtagcct gtgatttcaa ttttcgggcc ggtgtacatg gtttcgagct gatcaatgta 3695821 ttttttcatc gtttgaaaat ctgattttgc ggcttctagt gcttgggttt gctggccgtc 3695881 aaattgaaag agcttattca gggtgtctga aatcagccgc tcagcctgtt ctgtttccat 3695941 ccgaaaaaag gaatcattga ctgtcggcag gctgacgatg tgatctatgg ctgatgtctg 3696001 gcgattgact gcgtcagtga gctgctctgt cacttctcgt gcatgcttga ccccatgtct 3696061 cgcatcgtgt gagagaaaag cctctgcgat catgccgtgg gagttagatt ctacagagga 3696121 aatcgcatgc tgtgtttgtt tcagcacttt tttgtattcg tcgataaata tgccaaagaa 3696181 aaggagaaaa ggcttgtggc actcctcgta aaaggtccgg atggcatctc cgccttttcc 3696241 tttcagcgca tccttcatgc ctgccagatg ctcaacgctt ttttccagct tctccagctg 3696301 ttgtttttgc ttgtccagtt tctcaatcgt atgctgaatg ccctcgtgaa gagcgtggac 3696361 atctaatgtt ttcaatccct tgtcctcccg cgctttattt catggaagat gatatgtttt 3696421 cgtccgtttc cttcatggcg tttaccgcgc tttccgtttg tgcgatatgc ttggccagaa 3696481 cagacgcata tgcttcagtg agctctttga tgtccttatt taattgctcg atggacttca 3696541 caacattcaa atggtttctg cctgagagat gaccgggcaa tgaggacttg agttcagctg 3696601 aattcttgag ctgagaaagc ccttgcttca ctgtgtcata caccatttta atttcctgtg 3696661 ccatttgtgc tcacctcact ttttatgttt ttccttctct atttcatgct ctatcctcgt 3696721 gatttggcgt cttatagaat acacatcgcc ctctaatgag tggatttttc cttctatgct 3696781 ttcgatgatt ccgctgactt gatcgctttt gatttgctga tatgctttgt tcattccttc 3696841 acgaatatct tcaaaccgct cagcatgtgt tcctctccat gcctcccggt taagatgagg 3696901 ccggtgaatg agatgctggg cctcagagaa atcgtgtttg atttgcctaa tttcgtgcag 3696961 cactcgtttt aattgatgga tctgttcctg cttttcatgt aagtcggctt ttaccgaatg 3697021 taacaacatt tcactatgca tgccgcaaca cctcgtgttt ctatcaaact gtgtaaattc 3697081 tttacaatac agactatttt catattacat gatgggtcat attggataaa taggtaaaaa 3697141 ggattgtctt gagaggtata gaactggttc taaattgcta aaaatacgat ctcatcaccc 3697201 tatgaaagga gaaaacaatc atagtaggga ctttttattt aagcctttaa tctctcctcc 3697261 agttctaatt tttcctccca cttaactgtt tcttatagtc aataaagctc ataaaaaaac 3697321 accttccctc gaaggcgctt ctccatctta tttagatccc catacagcct caccgctggt 3697381 attcagcaca ctaaacgtca tgacgttctt ctctctcacc gaatcccact ggcgtaaaaa 3697441 taccccgtta tacttcttgc ctgctaacgt gatgtcggcg gtgttttttc cggttttcct 3697501 ccatgttccg gtcatttccc cggaaatggt gtggtttttg ttgagctgga tgttgatggt 3697561 ttgtttgatg tcggctgaga tgtcttttcc gtgctggata agtttgtatg ttcctgtgat 3697621 gtctttttgt tttacttctt tcaatgtttc gcccgcataa cgatatggtg ctgctaccgg 3697681 ccagccgtct ttgttcatga acaattggtg gactctgact tcgtgttctt cacccctgcc 3697741 cgggaagcgg gtgtggaaga ttaaatagga acgcccggtt ttttcatcat agtatgcgga 3697801 gttgtggcct ggtgagacgt acccggtgcc tttttcattt tctgtttcaa aagtgtagct 3697861 gcccatgagt ttgacgccgt atggttcgat ggaacggtcg tcgaagaatg tgcctccctt 3697921 gccgcggacg tcgagcattg gattgccttc tgcatcatag taagggccgt ccggtttctt 3697981 ggagcgggcc acacggatgt tgtagccgcc tgttgcatcg agaccgccat atgataggta 3698041 taagtagtag tattgggtgt ctggattgta gagaacatac gggccttcga ttctgctgtg 3698101 gttgccgccg agcagttttt tcccatatcc ctgtccagga agcgggaagc ccgttttcgg 3698161 attcatttca agtatgaaaa tgccgcctga gtatgatccg tacaccatcc acagcttgcc 3698221 gtctttatca aagaaggtat gcgggtcgac gacattcgga tgtttggttg catcatacgg 3698281 tgttccatcg ctgcttgtgc cttccattcc tgatttcaaa aagatgcctt tgtttttgta 3698341 tgggccttcg atgttgtcag caacggcaac acccatggcg gatcttggcg aatcgccgcg 3698401 gcaggcgttg tagtacatgt agtatttgcc gtccgccagc tgcgtgacgt cagccgccca 3698461 aagagtatcg gattgcgccc attcgaaggt ttcttttaat tcttcataga cattcgggat 3698521 aagtgggttg tcattgctta cgctggtggt cagctgctgc cattgcatga ggtcattcga 3698581 tttagctgaa gcgagatgag atccaaaaac ataaaaagtg ccgtttgttt caatgatgga 3698641 agggtcatgg acgctgactt ctttaaatat aggtttttgt gcatagacgg agtttgggag 3698701 ggtgaaggcc atgataagag ctgcaagaaa acatacacgg aacaatcggt tgaacatcta 3698761 aacaattcgc ctctcttttt tattaaattt taaacgctta catttctcta tgaagatacc 3698821 ccggcctatt aaaacagccg aatgttttca tattcatcca gataggtgat ttctcacttc 3698881 acttacatag tcagactgat gtctgtctgt tttgcgcaga acttgttgct tgcatatcct 3698941 ctccttcata gttcaactct tttgctgttt ctccttcttg catcacgtct gtttttcttt 3699001 cgcgtacatg taataactgc tttgtcaggt tttgcatcaa ctgtgataca gccatttcgt 3699061 tgtcggcgtt ttttaagatg atgcctgatt gcccgtcaac accagagtca ttcggctggc 3699121 tctttataaa acgccttgcg aaaaatacga cttagtaaac gcatattgag agttagacag 3699181 cggcgcttgc ctccttgtct ggatatcgtg tgcaatcgct gaaaaaacct gttctgcttt 3699241 ctgcgtcacg ctattacaat agcaatctaa cttgttaaag actataaaaa aaccttttga 3699301 cttctgctgc tgaaccaatt aatataatac tcagttaata gttatcagaa tttttaggaa 3699361 ttgagtgatt catatgacac tgcataaaga gcgtcggatc ggccggctgt ctgttctcct 3699421 gctgctgaat gaggcggaag aaagtacgca ggttgaggag ctggagcgag acggatggaa 3699481 ggtctgtctt ggcaaggtag gatcaatgga cgcacataaa gtagtagccg caattgaaac 3699541 cgcttccaaa aagagcggtg tcattcaatc tgagggttat cgggagtcac atgcgcttta 3699601 tcatgcgacg atggaggctt tgcatggcgt gaccagaggt gaaatgctgc tgggatcgct 3699661 gcttcggacg gtgggattga ggtttgccgt tttgagggga aatccttatg aaagtgaagc 3699721 ggaaggcgat tggatcgctg tctcgcttta cggaacaatc ggggcgccga ttaaaggtct 3699781 tgagcatgaa acattcggcg ttggaattaa tcacatatga aacagcccat agatcttaga 3699841 cgataggggg ctatgcgtga aaacagaagt tcacagcata gctccttttt gtatgggcgc 3699901 tttaccaaag taaagaaaaa ggagttgggc ttatggtgac tttagacggt tcttcattga 3699961 caacagccga cgtcgctcgt gtgctgtttg attttgagga ggcagcggct tctgaggaaa 3700021 gtatggagcg cgtgaaaaaa agcagagcag cagtggaacg gattgtacgc gacgaaaaga 3700081 caatctacgg catcaacacc ggatttggca aattcagcga tgtcctgatt cagaaagaag 3700141 actcggcggc gctgcagctg aatttaatcc tttctcatgc ctgcggagtc ggcgaccctt 3700201 ttcctgagtg tgtttccagg gcaatgctgc ttttgcgcgc caatgcgctg ttaaaaggct 3700261 tttccggtgt acgcgctgag ctgatcgagc agttgcttgc ttttttaaat aaacgcgtcc 3700321 atcctgtcat ccctcagcaa ggatcacttg gcgcaagcgg agatctggcg ccgctttccc 3700381 acttggcgct tgcgctgatc ggacaaggag aagtcttttt tgagggggaa agaatgccgg 3700441 caatgacagg cttgaaaaaa gcaggtattc aaccggtaac gctgacatcc aaggaagggc 3700501 ttgccttgat taacgggact caggccatga ctgcaatggg ggtggtcgcc tacatcgaag 3700561 ctgagaaact agcctatcaa acagaacgaa ttgccagctt aacgattgag gggttgcagg 3700621 gaattatcga tgcatttgac gaggatattc acttagcccg cggctatcag gagcagatcg 3700681 atgtcgcaga acgaattcgc ttttatctat ctgacagcgg cctgacaacc tcccagggag 3700741 aactgcgggt acaggatgcc tattcattgc gctgtattcc gcaagtacac ggtgcgactt 3700801 ggcagacact aggatatgtc aaagaaaaat tagagattga aatgaacgca gctacagaca 3700861 atccactcat tttcaatgac ggtgacaaag tgatttccgg cggaaacttt cacggacagc 3700921 caatcgcctt tgccatggat tttctgaaaa tcgcaatatc agagcttgcg aatatcgcag 3700981 agcgtaggat cgaacgactt gtgaatccgc agctgaatga cctgccgccg ttcctgagcc 3701041 ctcatcccgg tctgcaatcc ggtgcaatga tcatgcagta cgccgcggcc tcactcgttt 3701101 ctgaaaataa aacactggcc catcctgcaa gtgtggattc cattccgtca tccgccaacc 3701161 aagaggacca tgtcagcatg ggaaccatcg ccgctcggca tgcttatcag gtgatcgcaa 3701221 atacaaggag agtcattgcg atcgaagcca tttgcgcatt gcaggctgtt gaatacagag 3701281 gcatagaaca tgcagcgtcc tatacgaaac agctttttca agaaatgaga aaagtcgtgc 3701341 cgtccattca gcaggaccgt gttttttcct atgacattga acgcttgact gactggctga 3701401 agaaagaatc tttaatacct gatcatcaga ataaagaact aagggggatg aacatatgac 3701461 tgatgtaaaa aaatcaatcc gtgccaacag aggaacagag cttgaatgct taggatggga 3701521 gcaagaggca gtgcttcgga tgcttcgaaa caaccttgat ccagaagtcg ccgagaagcc 3701581 ggaggacctc atcgtatatg gcgggattgg caaagccgca cgggattggg acgcttttca 3701641 cgccattgag cattccttga aaacattaaa aaatgatgaa acattgctcg tgcaatccgg 3701701 aaagcccgtt ggcatgttcc gtacacaccc gcaggcccct cgcgtgctcc tagcaaattc 3701761 tgttcttgtt ccgaagtggg cagactggga gcatttccac gaacttgaga aaaaagggtt 3701821 aatgatgtac ggacagatga cggctggcag ctggatttac attggctcac aaggcatatt 3701881 gcaaggaacc tatgaaacct tcgctgagct ggcgcgacag cacttcgggg gcagcttaaa 3701941 aggaacgttg acgctgacag cgggtctcgg cggaatggga ggcgcccagc cgctgtcagt 3702001 cacgatgaat gaaggcgtcg tgattgccgt cgaggttgac gagaaacgca tcgacaagcg 3702061 gatcgaaaca aaatactgcg atcgaaaaac agcatcgatt gaggaagcct tagcttgggc 3702121 tgaagaggca aagctggcag gaaaaccttt gtccattgca cttctcggaa acgcagctga 3702181 ggtgcatcac acacttttga accgaggcgt caaaattgat attgtgacag atcagacatc 3702241 tgcccatgac cctttaatcg gttatgttcc cgagggctat tcccttgatg aagctgaccg 3702301 tttgcgtcaa gacactccag agctttacgt gcgccttgcg aagcaaagca tgaaaaaaca 3702361 tgtcgaagcc atgctggcct ttcagcaaaa gggctctatt gtatttgact acggcaacaa 3702421 tatccggcaa gtcgcaaagg atgaagggct ggagaatgcc ttcgattttc cggggtttgt 3702481 ccctgcctac atccgcccct tattctgtga aggaaaaggg ccgttccgct gggcggcgct 3702541 ttccggagat ccggcagata tttaccgtac ggatgcgtta ttaaaagagc tgttcccgac 3702601 aaataaagcc cttcaccgct ggattgatat ggcacaggaa aaagtcacct tccaaggctt 3702661 gccgtcccgt atctgctggc ttggatatgg agaacgaaaa aagatgggcc tcgccattaa 3702721 cgagctggtt agaaccgggg agctaaaagc gcctgtcgtt attgggagag atcatttgga 3702781 ctgcgggtct gtcgcctctc caaaccggga aacagaagcg atgaaggatg gaagtgacgc 3702841 tgtcggtgat tgggctgtgc taaatgcgct tgtcaacacg gcggcgggtg caagctgggt 3702901 ttccttccac catggcggcg gcgtcggaat gggctattcc cttcatgccg gcatggttgc 3702961 agtggccgat ggaagtgagc tggctgacga gcggctcgcg cgggtcttaa cgagcgaccc 3703021 aggaatgggc attatccgtc atgcggatgc gggttatgaa cgtgccgttg aagtagcgaa 3703081 ggaacaggac attatcgtgc cgatgcaaaa ataaaggagt gatgacatgc caaagcaaat 3703141 tgatacgatt ctcatcaaca tcggtcagct tttgacgatg gaaagcagcg gtccgcgggc 3703201 aggcaaaagc atgcaggatc ttcatgtgat cgaagacgct gttgtcggca tccatgaaca 3703261 gaaaattgtg ttcgccggac aaaaaggggc tgaagccggt tacgaggcag acgaaatcat 3703321 tgactgttcg ggacgccttg taacgcctgg cctcgttgat ccgcacaccc atcttgtatt 3703381 tggcggatct cgtgaaaagg agatgaacct taagcttcag ggcatttcat atttggatat 3703441 tctggcgcag ggcggcggga ttctgtctac agtcaaggat accagggcgg cttcagaaga 3703501 agagctgctg caaaaagccc attttcatct gcaaagaatg ctgtcctacg gcacaaccac 3703561 agcagaagtg aaaagcggct acggcttgga aaaagagaca gagctcaaac agttgcgtgt 3703621 cgcaaagaaa ctgcatgaaa gccagcctgt tgaccttgtt tccacattta tgggagccca 3703681 tgcgattcct cccgaatatc aaaacgatcc agatgatttt ctggatcaaa tgctttccct 3703741 tttgccggaa atcaaagagc aggagctcgc cagctttgct gatattttta cagaaacagg 3703801 cgtttttaca gtcagccaat cccgccgtta tttacaaaaa gcagctgagg caggcttcgg 3703861 attaaaaata cacgcagatg aaatcgatcc gcttggaggt gctgaattag caggtaagct 3703921 aaaggccgtc tcagccgacc atttggtagg tacatcggac gaaggcataa agaaattggc 3703981 tgaggcagga acgatcgccg tcctcttgcc gggcacgaca ttttatcttg gcaaaagcac 3704041 atacgccagg gcaagagcta tgattgatga aggtgtatgt gtcagcttgg caacggattt 3704101 taatcctggc agctcgccga ctgaaaatat ccagctgatt atgtccattg ccgcgcttca 3704161 tctgaaaatg actgcagaag aaatatggca cgcggtcaca gtcaatgccg catatgccat 3704221 aggaaaagga gaagaagccg gtcagctcaa agctggccgc tcagctgatc ttgtcatttg 3704281 gcaagccccg aactatatgt atattccgta tcactacggg gtcaatcatg tacatcaagt 3704341 catgaaaaat ggaacaattg ttgtcaacag ggagggagcc attcttggat aagtaccctt 3704401 ttctcagaga ggccggatct tcgtttaaag accgggatgt cacaaaaatg agcgacctga 3704461 tcgcaacatg ggacggccag gacattaagg gaccggcgtt gataggtgtc cccctatcaa 3704521 aatcctccat cagtcattca ggcgcttcct ttgcacccgg aacaatacgc caggctctga 3704581 aacattcatc agcctattct gctgagcttg gagagcacgt cgtatcagag cttctatatg 3704641 acctggggga tatcgatatt catgtcactg atatcgtaaa gtcacatcat cacattttcc 3704701 aaaccatgca cgctctgctt tcggatcatc cggattgggt gccgctcata cttgggggag 3704761 ataactctat cagctactcc acaataaaag cgatagcaca aacaaaagga acgacagcgg 3704821 tgattcaatt tgatgcccat cacgatgttc gcaatacgga ggacgggggg ccgacaaacg 3704881 gcaccccctt ccgccgcctt ttggatgaag agatcattga aggtcaacat ttgatccagc 3704941 tgggtatcag agaattcagc aacagccagg cctatgaagc atatgcaaaa aaacataacg 3705001 tgaacattca cacgatggac atgatccggg aaaaaggact aatcccaacg ataaaagaga 3705061 ttttgcctgt tgttcaagat aaaacagatt tcatttttat atctgttgac atggatgtct 3705121 tagaccagtc ccatgcaccc ggctgtccag cgattggccc gggcggcctc tatacagacg 3705181 aattgcttga agcagtcaag tacatcgcac aacagcccaa tgttgccggg attgaaattg 3705241 ttgaagtcga ccctaccctc gattttcgag atatgacaag cagagctgca gctcatgttc 3705301 tgttacacgc attaaaagga atgaaactct ccccattcaa gtgatcttct ggcaggttgt 3705361 attttgggta taagaaactc atctgcctaa ggaatggcag ctaaaaggag ggcgagacag 3705421 tgaatcttca ggagaacagc agccaacagc taaaacgcac aatgaaaagc aggcacctat 3705481 ttatgatctc attgggaggc gtcataggca caggactttt cctcagtacg ggctatacgc 3705541 tacatcaagc cggacccggc ggtacgatac tcgcttatgt aatcggcggg ttgatgatgt 3705601 acctcgtcat gcaatgtctc ggcgaattgt cggttgccat gccggtgacc ggctcttttc 3705661 aaaaatatgc tacaacattt atcggtccat ctaccggttt tatggtcggc atcatgtact 3705721 ggatcaattg ggtggtgacg gtaggctctg agtttaccgc atccggtatt ctcatgcagc 3705781 gctggttccc tgacagcagt gtatggatgt ggagtgcgat ttttgcagcc cttcttttta 3705841 tatgcaacgc attttcagtt aagttatttg cggaaactga attttggttt tccagcgtaa 3705901 agattgtcac cattatttta tttatcattt taggaggagc cgccatgttt ggcctgatct 3705961 ctttaaacgg aacggcggat gctcctatgt tgtcaaactt cacagatcat ggcgggttgt 3706021 ttccaaatgg ctttctcgcc gtttttatcg cgatgatatc tgtgagcttc gccttttccg 3706081 gtacagagtt aatcggcgtt acagcaggag aatcagcaaa tcctcaaaag gatataccgc 3706141 gatccatccg taatgtcgca tggagaaccg tgattttttt cattggcgct gtcttcatat 3706201 tatccgggtt gatttcatgg aaggacgcag gcgtgattga aagcccgttt gtcgccgtat 3706261 ttgcggagat cggaattcct tacgctgctg atattatgaa tttcgtaata ttaacagcct 3706321 tgctgtctgt cgccaactca ggcttatatg cttcgacccg tatgatgtgg tctttagcaa 3706381 atgaaaacat gatcagctcc cgttttaaga aagtgacatc taaaggcatt cctttaaatg 3706441 ccttaatgat cagtatggct gtatcttgtt tatctctcgt ttccagtatc gtggcccctg 3706501 gaactgtcta tgtggtgatg gtcgcaattg ctggatttgc aggagtcgtg gtctggatga 3706561 gcattgcctt gtcccaactc ttgtttcgaa agagattttt gaaaaaaggg ggggatgtaa 3706621 aagatctgac atttcgcacg ccgctttatc ctcttatgcc tatagccgct ctcttattat 3706681 gttctgcttc ttgtatcggt cttgcttttg atcccaatca aagaatcgca cttttctgcg 3706741 gagttccttg tatcatcctt tgctatctca tctaccattt caaaagaaat gttacaaaag 3706801 cgaaaaaaat cagccaagag gaatatccag ccgatcacat cctataatta aaaaagcaca 3706861 ccccgctcag catgggatgt gctttatttt ttattctgta attaacgtat gaatcagctt 3706921 cggcgccttc gcttccgcgg cgatgcggat gttgtcatag acttttgcga tgacttcatc 3706981 gacgttttct cggttagcgt aaagcgttac gagcggttcc cctttttcta ctttgtcgcc 3707041 gacctttttg cggagcatga tgccgacggc taaatcgatt tcgtcttctt ttgtggcgcg 3707101 gccggcacct aacagcatcg ccgcgacgcc gatttcgtcc gcgacgattt cagagacgac 3707161 acccgcttct ttggcaggca catcaatttg atatgcggct tgcggaagct tagacggatc 3707221 gtcaacaatt gagctgtcgc cgccttggtt tttcaggaaa tccttgaatt tctcaagtgc 3707281 tttgccgttt ttcatgactt cttccagctt cgctctcgct tcgtccaatg tatcggcttt 3707341 tttcgcaagc acaaccatct ggctgccgag cgttaagaca agctcatgaa gatcctcagg 3707401 cccctcgcct ttgagcgtgt cgatcgcttc tttgacttca agcgcatttc cgatcgcaaa 3707461 gccgagtggc tgggacatgt ctgaaatgac agccattgtt tgacggccga cgttatttcc 3707521 gatgcgtacc atcgctttgg caagttcagc tgcgtcttct tctgttttca tgaaggcgcc 3707581 cgctcccgtt tttacgtcaa gcacgatggc gtccgccccg gcagcgattt ttttgctcat 3707641 aatcgagctt gcaatgagcg gaatggaatt gaccgttccc gttacatcac gaagcgcgta 3707701 cagtttttta tcagccggcg ttaaattgcc gctttggccg atgaccgcaa ccttgtcgcg 3707761 gttcacaagt ttaataaatt catccttcgt cagttccacg tggaagccca tgattgcctc 3707821 taacttatca atcgtgccgc ccgtatggcc gaggccgcgg ccggacatct tagcaaccgg 3707881 cacatcaaga gccgcaacaa gcggagcgag aacgagcgtt gtcgtgtcgc cgacgccgcc 3707941 ggtagagtgt ttatccactt taattccttc aatggcagaa agatcaatcg tttcaccgga 3708001 gttcaccata gccatcgtca agtccgcgcg ttcacggtca ctcatatcct ggaagaaaat 3708061 cgccatagca agcgcgcttg cctgataatc aggaatgctt ccatctgtat agccgttcac 3708121 aaaaaattga atttcttcag tggtgagttc ttttccgttt tgttttttga tgatgatatc 3708181 taccattctc atgtttggtc accgatcctt ttcgattaag ttcagtaaat caagcccaca 3708241 attgctgctg ataaaaagct gacaagcgta gcaccgtata ataatttcaa gccgaaacga 3708301 gcgacgacat ttccttgctt ttcattcagt ccttttacgg caccggcaat gattccgatt 3708361 gaggagaagt tcgcaaatga cacaaggaat accgatacga tcgctgttgt acggccgctg 3708421 aaatggaaac cgttttgcgt aagcgacgtc atggcgacaa attcattcga taccattttt 3708481 gttgccataa tgcttcccgc attaacagct tcattccatg ggataccgac aagaaaagcg 3708541 aatggagcaa acacatatcc aagaatgcct tggaacgaaa taccgaatac tgcattaaaa 3708601 atgccattga tcaatgcaat aatcgcgaca aatccaatca gcatcgcagc gacgacaacc 3708661 gctactttga aaccgtcaag aatgtattct ccgagcactt cgaagaagga ttgtttttct 3708721 tcttcctcaa cacgaagcat atcctcttct tttgcaacct cgtacggatt gataatagaa 3708781 gcgataatga aaccgccaaa taagttcaaa acaagcgctg ttacaacata ttccggtttc 3708841 agcattgtca tatacgcacc gacaatcgac attgatacag ttgacatcgc agatgcgcaa 3708901 agcgtgtaca agcgctgctg atttaaaaga ccgagttctt tcttcaagga gataaatact 3708961 tctgactgcc ctaaaatcgc agaagccact gcgttatacg attccaatct tcccataccg 3709021 tttaccttgc tgagggcaag gccgatatat ctaatgataa acgggaggac tttccacttt 3709081 tgcagaatcc cgatcagagc ggaaataaac acgattggca agagaacatt cataaagaat 3709141 gtcgtttggt ccgcattcac caagccgcca aacacaaagt taattccctc tgccgcgtat 3709201 tcaagcaggt aaccgaatcc ttttgcaaat cctcccacga ggaaattccc tattccggta 3709261 ttgaggagaa tgtagccaag aataaattgc aaaatgagca taacaacaat tgggcggatc 3709321 ttaattcttt ttttgccgct gctcgcgatc cacgcgaggc ctaaaaacac gattaaaccg 3709381 ataatcccaa tcaaatactt catatgtgtt tctcctttat ttgtattcgc ttacaattac 3709441 tgtttcctca gaaaacggaa agcagtctgc cttccgtcag ctcttaatag ttgtctccgc 3709501 ctgatgcatt ttctcctttt acgatagaaa cgcctgcgct ggcgccaatt cggcttgctc 3709561 cggcctctac cattgtgtct acatcttctt tcgttctgac gccgccagat gctttcacgc 3709621 cgatatcagg ccctactgtt ttgcgcatta aggcgatatc ttccttcgtt gcgccgcctg 3709681 tagaaaagcc tgttgatgtt tttacgaaat ccgctcccgc agacaccgct aaacggcatg 3709741 cacgttcttt ttcttcatca gtcagaaggc acgtttcgat aatgactttg acaagcgctt 3709801 ttccggctac agcttccact acaccgcgga tatcagcttc caccacatcg tcttccttgt 3709861 cttttaaagc ggcaatatta atgaccatat ccacttcagt ggcgcctttt gaaatggcgt 3709921 cttttgtttc gaacgctttt gtttcagttg tattggcacc gagcgggaag ccgatgaccg 3709981 tacaaacgtc gactccagtt cccttaagct cttttgcagc aagctccacc catgtcggat 3710041 tgacacatac tgaagcaaat ttgtatgttt tcgcttcttc aattagtttt agaatgtccg 3710101 ctttttgtgt atgcggtttc aaagctgtat gatcaattat gttggctaat gacatccttc 3710161 gcacacttcc ttttttgtta agatattttt tagcataacc gacttttgaa catatgtaaa 3710221 ttggtaattg aaattttgtt caatgaaagg tttgaacgtg tcacaaatca ttaacaagcg 3710281 ccctcgcggt atgctggtca atgattaaaa cgttggcata ttttccggtt aatgctccgt 3710341 gaatggaaga tacttttctg cttccgccgg caactaaaat ggagcgttcc ttcagtctaa 3710401 ggtcttgaag ctcaacaccg atggtccggt cattgatggc gctgctgcaa atattccctt 3710461 tcgcatcaaa aaagcgtgaa caaatatccc cgacggcctg ttttttcagc agggctttct 3710521 cttcttcgtt aaaatatccg agccgaaaca acagcgcttc atcacggaca gtcccgaccg 3710581 taaagagagc gatattcgcc tgcttgccca tctcaatgat ccgttcaata tgacggtctt 3710641 tctccaccat tcgcttcaca tccgcattat caaacacgac gggaagcggg agatagcgcg 3710701 gcatcgtttg aaaagcctct gcaaacagct gaatcgtttc agccgaatac gtgtttaccc 3710761 gggaatggct gatgccgcct ttcagctgga cgacctcgac gccttttacc tgcttcggct 3710821 gcatgttttg cgcgatttga tacatggtgg ttccccagct gacgccgaca atgtcgccgt 3710881 cttttaccgt ttcatgcata tattctgcac catagcggct taggtcatgt gtaattcctg 3710941 cataatcggg tgtcggggaa aacacaacat gcgcctcaag gagcccgtat ttctcttcaa 3711001 gtatggaacc gagcgcatcc aaatcctcaa aagggtccat gacgcgaatc tggacatacc 3711061 ctttttcctt tgcatattgc agcagccggg aaacggttgg ccttgaaatg ttgagctgct 3711121 cagcaatttg ctgctgactg tagtcagact gatagtaaag ccttgccgct tctatgctta 3711181 attgctgttt ttcccgatcc attctgcacc tccctgtgga tcagtcctga taaaactgct 3711241 tttgatttgc ttttattata caggctggcg ccggctttca tccacctgat ttctaagaaa 3711301 ctgaaaaacg ctctgggcgc ggacctgccc agagcttact tctcccaagt catatgctga 3711361 taaatgcctt tcataatggc gtacattcca tataggatca ggcctaatgc caatatagac 3711421 agaatcaatt tgccatgcgg ctgctgcgcg agttctgcga gcgcgccgtc aaagcctctt 3711481 gtgtcgtcgg gatcagcggt catggctgtc ttgatgagaa aatagccgat agccgagaaa 3711541 ataatggccc gggcgatatt gcctgcgcgt cctgtgtttt tcgtgatgca tatcatctgt 3711601 ttgttcattt ttgatgtatc gaattctttc ataaaagcag cccgaacgcc tttcataaat 3711661 tgaacaatcg caaatacgat aaaacccgca cccgtaagcc ctgtgagcca ttggccgaac 3711721 ggctgcgcca atacataagc ggaccacgtc tgttctgaag tgccgccgtc cccttggcca 3711781 aacacaaatc gcaaggcatt ccaagcgatg gatgtgtaaa cagcggcact gaaaaagttt 3711841 cctattctcc gcgacaggcc tcgcctgctg tttccgtgcc cctccgtgtc cttgatcgcg 3711901 cttaacacca tccagatcac atagccgata aggccgatgc ctataaaaaa aagcaatagt 3711961 gacccatacg gcatgcgtga tagcgtttgg agagctccgc tcgaatcttt ggcgcggcct 3712021 gccccggcag ccgtcataaa agccaaaacc ccaagcagaa taaaaacgcc gccgaatgca 3712081 aaataaccaa gcctcccgaa tcgtttgatc caaggcttgg tttcctgttt tatttttgac 3712141 atgtaccggt ctttcaccgc catgtgtcca accctctttc acagaaatct ttactgtaac 3712201 attcccgatt gaacaaagtt gaaacagctc ctgcctcagc tatggctggc tgagatacgt 3712261 ttttgctgtt tagctgattg tgcaggtgtc atccaagcag ccgctgcggc agctgtgact 3712321 ccgcctgcta atttcccaat gatcatggcc gccgccattt cttttttcat tccagctaca 3712381 aaaccgagat ggctgccgag tacaaaggcg ccgctgaccg caaacgcgac attgatgacc 3712441 tttcctctcg gcgtcatatc ctttaatgaa gccagcattg ggatatgatg cgccaaagag 3712501 gtcactaagc ctgctgttgc tgtctcatct aaatgaaggc atttccccag agcctgaagc 3712561 ggttttttaa aggtttttgt aataaatgcc gtcatcggga acgcccctgc cagagcaatg 3712621 gcgatggtcc ctgtcgtttg tatccctgtc tcgacattct ccattcccgg aatcagcaca 3712681 atgccggtca tcgtttcaac agaaacagct gcaagcccga taatcgcaac catactgacc 3712741 gctttcccga agagatgaaa caactgaatc attctgtcgg tgtatcgcca taacccaaaa 3712801 gcgatgacag cagataacag actcgggatc agaagatttt tacctatcat gccgatgtca 3712861 aagcctgcgc ataatccgcc gattaagcaa ccgatcggca ctgtgcacag cccgattaat 3712921 atgcctttcg caaaatacgg atgatcctct ttttcgatga tgccaagagc gacgggaatc 3712981 gtgaagacga ttgccggccc catcattgtt cctaaaaaca cccatgaaaa cagcccggcc 3713041 tgcggatctt tcgccatttc tccagccagc gcatatcctc ccatatcaat cgccaaaatg 3713101 gtgttcgcaa aggaagaagg atccgcgcca atcgctgtgt aaaacggagc aacaatggga 3713161 atcaagattg ctgccagcac gggcgccagc gatacaattc cgatcatgga cagcgccagc 3713221 ggccccatag ccttaaagcc gtccgcaaac cgctcgccta gcccccatct gtttcccaaa 3713281 caataatccg ctgctcccca tagtaaaaag gcagccaaaa tgaatacaac cgcgtcattc 3713341 accgtcatgg ttttctcctt tttcaaacgt atgattggtt ttatcatatc atctgaaatc 3713401 accgaataga gttgatctta ttcaatatga gctaaaaatt cttttatatc ggctttttca 3713461 acggctgtta taatgcgtcg cgctttttct tgcgggaccg ttaatgtcaa tttttctatt 3713521 atgtcttctt cagacagctc atttcctggt gccccttttg ggcagtccac acgcgcttcg 3713581 caaatccggc cgtctgataa ataggcccgg acaatcgtga aacggccttt tggaacggca 3713641 tgaggagccg gctgaatagc attgtcatat acgcgctgaa ttcgccccat tgtcgtttga 3713701 accccgtttg ggatcggctg gctgctgaaa tgttcaacgg tcaggccgtg tccatgcaaa 3713761 gcaagagcaa tcacatattc aacgctgaaa cggccttcct ctccagcttt tggagatctt 3713821 tccgtcaatg cagcatctcc gcctggcgga aatatcactt caatacgttc ggtattggca 3713881 gcagaaatgg tttcttcgga gataagctgt cgtaccgcat ctgcagcatg gtgtgccgcg 3713941 gaacaaaatg gatagatttt aaaccataga cccggctgca caattctcca cggtgccccc 3714001 caatcgttta gcaaagtgtg ttgtgctttc tcaacgtcac cgtacagact gaagaaacca 3714061 gtttctccat caagtgccgt gcgggacccg ccaaattctg attgggccag cttaacggcc 3714121 agcaagccag cctgagccgc caaaccggcg tgcagcggtt tcatttctgt tccaaattgc 3714181 accctcatcc cagcagattg cgtagccgca aaaccaattg ctttttccaa ctcttcctga 3714241 gtcagctcct cagcataacc tacggcgcag gcagcagcga tggcaccaag cgtacctgta 3714301 ttatgccagc ccttctcata gtggcggctg ccaattgatt ctcccagccg tgccatcact 3714361 tcaacaccaa caacataagc gccaagaagc cgctcgtcat gtccgcgagc ggcagaagca 3714421 ataagggccg gtacgatgac tgcactgggg tgtcctctta catcggagtg gacatcatca 3714481 aaatccaatg catgggcgat aaatccattg agcatcgcgg attgtaatgg cgcggccttt 3714541 ttgccctgtc cgataacagg aacaaggggc cggcctcctt catcctctat cagacggagg 3714601 agcttttgaa ttcctttatc ttctcttcct gcgaatgaag cggcagtaaa atcaagtaat 3714661 cccttttttg cttcgtgaat cgcgtcaact gaatgctcag gttgtgacgt tctcacagcc 3714721 tctgcaagac ctgctgtcag cccttgtttg ctcatttgat ggtctccaat acaataaccg 3714781 ccagctccgc aaagtattga gaggcaaccg taagggcttc ttcatccagt gtaaaggccg 3714841 gatgatgcca ctcctccgtc ccgttcgttc ccatccagac aaaaaatccc ggaatcttct 3714901 cttgatacag agcgaagtct tctccgcccg gagactgctc agcgtgaacg gtttgatagc 3714961 caagccgtgc cgcagcttcg gatgccgcat tcaaaaatgt gccgtcattc tgaacggaag 3715021 gcaaataagg aaaccacttg aattctgctt gtgccccata gcccgctgca attccttcag 3715081 ccactcgtct catatgctcg ggaacagcct gcctcgcttc tttttgaaag gttcgaaccg 3715141 tcccctccat ttcagcttgg tctggaatta cgttccacga ggtgcccgcc tgtactcttg 3715201 tgatactgac gactgcgttt tgcagtgagc tgatattgcg gctgaccaca gattgcagcc 3715261 cgctgatgat ttgtccggct gcagcgattg gatcaatact gttatttggg atgccggcgt 3715321 gcccgccttt ccctttgatg acgatctcaa atcggtcaac acttgccatg agcggacctt 3715381 cctttacacc aatggtcccg acaggcagat ccggcttatt gtgcatgccg aaaatcgcag 3715441 aaacgccatt aagtacgcca gcttctagaa cctttcttgc tcctgcggca atttcttcgg 3715501 ccggctgaaa gataaagcgg actgtacctt tcagctcggc ccttctttga ttcagcaaca 3715561 tcgctgtgcc aataatagaa gcagtatgaa aatcgtgtcc gcacgcatgc attgtgccat 3715621 caaccttaga tgcaaatgga agattcgtct gttcttggat cgggagcgcg tcaatgtccg 3715681 ctcgtattgc tatcacgggg ccgtcttccc gtcctttgat ttctgcaatc acaccagtct 3715741 tcaattgagg gacatcaagt atttcgattt gctcctcctc aagccaacgg cggatttttt 3715801 tcgtcgtttc aacctcttga aatgacagtt caggatgttc atgaagatca cgccgcatat 3715861 tgattaaacg ggtatgaaac gctttgtcgg ccattgttct tctccccttc ttatataagc 3715921 tctgcaggct ctcccacctg cttgataaat cgtttcgtcc gttcgttttt cggatggtca 3715981 aacagttcct ctggcgttcc ctgctcgata atatggccgt ctgccataaa aatcacttga 3716041 tcagcaacct cttttgcaaa cgccatttcg tgtgtaacaa tgatcatcgt tgtttgtttt 3716101 tccgcaatgg acttgatgac ctgaagcacc cctgtgacga gctcagggtc aagcgctgac 3716161 gttggttcat ccagcaaaat cgcatgcgga ttgaccgcaa gcgcccgcgc aatgccgatt 3716221 cgctgctgct ggccgccgga cattgtgatt ggatagctgt cagccttatg ctccagaccg 3716281 acttgtttca gaatctccat tccaatacgt ttcgcttcgt cgcgtggttt atgttgagcc 3716341 acgattaaag cttctgtaat gttttgcaga gccgttttat ttttaaacag attgtagttt 3716401 tgaaagacca tggccgtttg ctggcgaagc cgatgtgctt ccttgcgtgt aaacttttcc 3716461 gcattcagtt tggcttctcc gatttcaata aggccttgat ccggacgctc taatagattt 3716521 aagcaccgga gaagcgttga ttttccggaa ccggacggac cgatgattgc caccacttct 3716581 ccgcgtttca cttctagatc gattccgtcg agcacgacga gatctttaaa cgctttgcga 3716641 atatttttta ctgttatcaa ctgatttcac ctctaagtcc ggtatggctt gctcatggca 3716701 cgttcaaaca agtcctgcaa aatgctgtag ataatggtaa gaacccaata gacgatcgca 3716761 accgccaaat acgtctcaaa atatttgagg tttcctgaag cgtacatctt cccttgggcg 3716821 aacatctcca tgacccctaa tgtaaaggcc agtgacgttt ctttcaggag cccgataaat 3716881 gtattgcccg ttgccggaat cgcatttcgg atcgcttgcg gcaaaataat ccgtctgtat 3716941 gcctgaaatt ttgtcatacc gacagacagg cacgcctcca gctgcccgtc atcaacagaa 3717001 ttgagggcgg cccggaagat ttctgccaaa taagctgcgt tttttaagct taacccgatg 3717061 atggcagctg tgagagctgt cattttgctc atctctggaa atagctgcgg cagcccgtaa 3717121 tagattaaga acagctgtac aagtgtcggc acgcctcgga aaaaggatat atacagcttt 3717181 gacagctgat gaagcactgg aattttgttt tttgtaatga gtgcgagaat aagtcctccg 3717241 ataatggcaa aaatcatagc tgctattgcc ataaacaagg tgatcggaag ggcctgaatt 3717301 aaagtcggga acgctgatat catgaattcc caatcaatcg tgttcattct ggtgagtcac 3717361 cgccgtttct taatgcttct gttctactgt gatatcttca ttaaagtatt tttcagagag 3717421 ttttttcagt gttccgtctt tacgcaattc atctagggcc ttattgactt ttttgcggag 3717481 cttgtcgtgc gcatcgtcct tggcaaatgg gaatgcaacc tgttcgtaaa caatcggatc 3717541 tcctgcaagc tttaatggca aaccggtctt cttgatttgc gcgatcaata cagttcggct 3717601 gttgacataa gcgtctacac ggccgtacgc aacatccttc agcgtaccct cttgtgtttc 3717661 gtacgttttg atattgattt ttttatcagg atctttgctt tcaaggtttt tcgcgtggtt 3717721 tgaaccgaga acggctgcga ctgtcttgcc ttttaaatcg tctactgatt tgatgtctgt 3717781 attgtctttt ttgacgacaa tctgtgttcc cgcataagcg tatggtttcg taaagttata 3717841 cgtttcctta cgttcgtctg tcacagctac ctggttggaa atggtgtcaa gcttgcctgt 3717901 ttgaagctct cccatcagcc cgctgaattc aagcagcttc cagtccagtt tcatgtcaat 3717961 tttcttagcg actgcttcca tcacttccac gtcaaagcct gtcagctttc cgttttcttt 3718021 ataagcaaat gggtaacttt gtcctgtcgc accgacatga agcacattgt catcctcttt 3718081 actgctgctg tttccattgc cgcaagctga gagcaccgct aataatgcag caacgaccag 3718141 cactgtccat tttttcatct tcatttgatt ttcccgcctt ttctattttt atagatcatg 3718201 tcgcaattgt tttttcatat agactgtgat atgccctttt ccaaggtctt gttcacctga 3718261 gcggacatat ccttttcgtt cgtacatctc aatcagccac ggatgcttat ccgctgttcc 3718321 gagtgagaca aacggaacct ttaacgtatc gcgaaggatt gtttcctcca gccattgaag 3718381 cagctttgtt ccgattcctt ttttaccggt gtcggggtcc acagcaaacc accagatatg 3718441 cggaacgcca tacggtcccg gctgttttcc ccaaggcatt ctcaaggtga tggtcgcgat 3718501 gatccgcccg tcttcttcca tgacgtagca agcattttcc cgaatatttt tcagcaccaa 3718561 atccaaatcc gcatgagcag cagcaaaacg aatgccgagc tttcgaatcg gttcataagc 3718621 ccgcaatgtc agctcgagaa gctgttcggc atcacgttca actgcaaggc ggtatcgtgg 3718681 cttcatctag cgttcctcct tactttgcat agcggtttac cggcttttcc aaaccgaagt 3718741 gctctcgtaa tgttgtgcct tcatattctt ttctgaacac gccgcgctcc tgtaaaatcg 3718801 gaaccacttg atcaacaaac acttcaattc cttctggaag aagcggaggc atgatgttaa 3718861 acccgtcaca cgctttcgta tccacccatt cctgcatctt gtcggcgagc tgctccggcg 3718921 tgccgacgaa gatatggtgg cctctggagc ctgcaacgta tttgtaaagc tctcgtatcg 3718981 tcatattgtc acgttcagcc atctcctgaa caagcttgaa gcggctcttc accgcattgg 3719041 aagcttcggc gtcaagcttc ggcagcggcc catcaagcgg atatgccgac aaatcaattc 3719101 cgcctaagta attttggaga atttgcagac cgacagatgg gataatcaga tcttggagct 3719161 ccttgtattt ggcttgcgct gcttcttctg tatcggcaat gattgggaaa atacccggca 3719221 taatggcaat tttttctgga tcacgtccga attccgcagc ctgttcttta atggattgat 3719281 aaaattcttg agctgattcc aggtggtttt gtgctgtgaa gatcacttcg gctgttttgg 3719341 cagccagcgc ttttccgtct cctgatgatc ctgcctggat aatgaccggc tggccctgcg 3719401 gggttcttga aacgtttaga ggtccgcgaa ccgagaaata ttctcctttg tggttcagct 3719461 catgcatttt ttctttgtca aagaattcac ccgtttcttt attacggata aaggcgtcct 3719521 cttcccatga atcccaaagc ccctttacaa tctcgacaaa ttcctctgcc cgctgatagc 3719581 gcaaatggtg ttcaaggtgc ttttcaccgc tgaaattcag cgctgttgat tcaatagatg 3719641 aagtgacgac gttccatccg gcacggccat tggacagatg atccaatgac gcaaactgtc 3719701 tggcaatatg gaatggctcg ctgtatgtag tggaggctgt tgctgtcagt ccgatttttg 3719761 atgtgacctg cgccaaagca gagagcaggg tgaatggctc aaaccttgtt aatacatttg 3719821 gatgtgattt gctgtcaatt gaaaggctgt ccgctaaaaa cagcatatcc agcttgcctc 3719881 gctccgctgt tttcgcaagc tctttaaaat aatccaaatt catgctcgca tctgacggcg 3719941 cgtccgggtg ccgccaagac gcaacatgat ggcctgtacc tgctaaaaat acccctaatt 3720001 tgatttgttt ctttttgctt gtcatggcga tactcctttt atcatgtttt taggctgaat 3720061 aatccgaaaa ataaactcct atattcctag tcgtttaata tgaataaatc aaaatgtacc 3720121 tttgtcttgg acgtttgtca atgagttaag attaattttt tctattcaag cgaaaagacc 3720181 cttgcgtgac catgagggaa cggcattgat tcattcaact agtgcaacct ctatatcggc 3720241 aagaaaactg agtctaatga agcaaagact cagttttctt ccaataattt catataagat 3720301 ttcgccattt cctttgcctt ttcttcgctt ttgcaaaccg cctatccatt cagacgccgt 3720361 aacgattgta taaaaaaaca gctgactcca gatattcaaa ccggaatcag ctgattgatg 3720421 tgaattaatt aagctcatga atactctctt ctgctttagc ggaaaacact ttaggctcca 3720481 aacagtcaag gtcttcatga aataaattta ctttttggat ttgccgattg tcatagtggt 3720541 ggaaatagta gtttccagtt tcgttgcaca tcacggaagt atattgcgta taatgaattt 3720601 cgtcttcttc cgttatcact gcgccctttg gtatcgtcat atttgccaaa atttgaaaag 3720661 cggctgttac acctttcgtt tcatcggccg ccggctctag atgttctttc aaataaacag 3720721 ctctgacaaa ccgggaaggc ggtgtataat cccccggcag accaacagtt cctaagcctt 3720781 ggccaaaagc agaaagggct aatccgccca tctctttgct ctctaattgc ttcggtctga 3720841 ttcctgtata ttgctgcaga ttggttacat gccatataaa gtcggggctg ttcgtcatga 3720901 caccaggttg attatcatag actttgaggc cgtctgctct tggttctatc gtcaggtttc 3720961 ggcccgtccg gtctgacaat atccagtgaa gcggtaaaac tgtatccaat agatctaatt 3721021 ttttctctac aatcgttaaa gatcgaatct tttcttttac gtcttccaaa gactgacaga 3721081 ctgacagcac ccatgtcaca aactcatgcg ggacaatgtg aacggtatct tcccgtatcg 3721141 ttttttcgta ctccgcatag cccggaaaat aaagcgccgc acaagataaa ccgctttcat 3721201 taatgccgtc ggcaaataat atatttccaa gttttctccc cataccgata aacgcgtact 3721261 gtgtctgatg ggcccttccg tcagcttcac tgttccagct gtaacggcgc ggatagagaa 3721321 tcacctctgt ccccagctga aatgcaaaat ccattgttct tgctaataca tgtttacggt 3721381 cagcagtttc caatgtaaga cttgtgcaca tttgatcagt ccccttttca attcagatta 3721441 atatcataca tattgtgaac gaattggttt tatcagcata acgaaagtca aatcgattcg 3721501 tcaaagaatt gacattacat caaataaaac gaaaaaatcc agcctttaga aggctggatt 3721561 ttttattatt tagccaaaac aagctcgtga atcgcatgtg caacgccatg ttcattattg 3721621 gagcgtgttt gaaagtttgc tgcttccaat acttctggga tggcgtttgc catggcaacc 3721681 ccgcagcccg cccattcgat cattgtcagg tcgttcccgt tgtcgcctat gcacatgact 3721741 tccgcctgtt caattccaag cagctgagcc agctggcgta cagcatttcc tttgctggct 3721801 tccgagtgca gaatttcata aaagaaaggc gcgcttctga ccattgtata tttttctctc 3721861 acgtcttttg gaatcgatgt aatgacgcgg cttaagttct ccggtttatc aataaacatc 3721921 actttcggga tgaggatatc ttttggcacc tcgtcaatct tgcggaaatg aagcggcacc 3721981 tgtgtcacat aggattcgta tacggtaaat tcgctaatat cccggttagg cgtatacaaa 3722041 ttagatgagt caaagaaatg catcggcgtc ttcagctcta agctcaggtc atataatgaa 3722101 gtcaaatcat cataaccgag agacagctct gagaccactt catttgtatg cgtattttga 3722161 acaagtgctc cattatacgc aataacatag tcgccttctt caattaaatt cagttcatct 3722221 aaatatctct gcacaccccc gataggccgg ccggtgcaaa gcacaatttt gacaccttcc 3722281 gcttttgccg cgtgaagggc gtcgcggacc tcctctgtta cttcatgatg atcatttaaa 3722341 agtgttccat ccatatcaat tgcaattagt ttgtacatcc tgcatctcct tcatgtcgtt 3722401 ttcaggctat agtcccatca tatcgttttt tctttttgat attcaaccgg aagagatggt 3722461 tttctccgga ttctgtttag acgccgccct tgtcttcgga tacgcaagcg cggtttccgc 3722521 tttctttctg ccttgacgcc gttttctgct tttttctgtt tcatcagcag aaagccggca 3722581 gctagaaaag gaatgccggt tatattcaag atggcaagct tcacacccgc cgcgatgaaa 3722641 aagaaccccc atgaagatga tggattccgt ctgatcatga cgtaagccgc catttccaga 3722701 acgatcagga tggcatgaag cactatgcca taaatcagca atacaagggc aaaaaacaaa 3722761 acataattca cgattgcccc tgagtacatc atagcgcgca tcatttgtat aaacgataag 3722821 gactgcatgg agccgctgat gacattaggg ttatagatcg tatagtcact aaataaatgt 3722881 ttgactttga gaaaagccca taatataaat atccattgaa tgatatgtaa aacaagcccc 3722941 gctgccacca gtctttcagc tttttgattt ctcatctttc tcctccctgc cggtctttga 3723001 ttcgattctt gtcatcgttt ttctctgtcc attttgctcc catatcaatg tcccgttttc 3723061 tcctcttttc agcgtgcttt tgagcggata ataagggccg aggtactgaa tctcgataga 3723121 cccgtcagtg ctttgggaaa tcaccttgta tgccataaaa ggcagctgta cctctcctct 3723181 tccttccatc acttccgttt ccacaacctc gtcttcggta aatgtgactg ttgctgattt 3723241 cacaccgtcc gttggcccgg gggcacgccc ctcatcccac gttccgtaat aaaacggcgt 3723301 ctcttctttt tgctgctggc agcccgatac catgatgcat acagcaatta aaaacaaaat 3723361 gccatatttg tttctcaagg ggatcaccat tctttcctcc ttttttgggc gaatgccgtg 3723421 ccactgtgcc aatgactaca taagttataa ggaattcacc cacaaggaga ctgatcacat 3723481 gaacccttat caatattaca gccctcagct gcctcagcag gaaccttact atagccacta 3723541 tgagtacaat ccttatccgc agcaggatgt atacgatcca taccaaatgg acagacagcc 3723601 ggcattggaa agaagaatcg cagcacttga acggcaaaat gaacagcagt caagagaatt 3723661 aacccgtctg acaaacgaag accgccgtca aaatcgggaa attgcacgga ttgccgaaca 3723721 ggtcaatcag ttaagccagg ctgttgaacg ccatacacgc cgcctaaatc ggctcaatca 3723781 gcgcctccgt acagtagaaa accggctgaa tatcccattt actgcagggg aaggcggttt 3723841 ctgagcgaaa caaagaaaaa aagcggaata cgattctccc atctcagggt ttcgttttcc 3723901 gcatttctta tatgttaaaa cggaacattt acataaaaag ggtttgtacc cagtatacaa 3723961 tctttaccgt tttcattcaa agatagaggg gctgaggaaa ataattgtag ttcctctttg 3724021 acggaatttc ttttcattca agttgcatga taataccgac tcacgtcaat cgatacatgg 3724081 agggatcatt catgcataat acacaacacg gcttgcagca gctgaaccaa tgccgccaaa 3724141 ctgctcagca gctcattcag caaacacagc aaagcagcca gcaatatcgc caaatgcttc 3724201 atcaggaaca gcaaaacatc caaatgctgc agcagattct aaaccacgaa caacaagctg 3724261 cacataccat tcagcaagca ctgcacgggc atgacatggc gattcaaaag tgccagcagg 3724321 ttgtcaacat gtgcaaccaa atgcaacagg aacttactgg acaatccagc gtcatgaata 3724381 cgaatgtgtc tacacttcca ttcggccaaa acacgacatt tcagcagcaa tcctaccagc 3724441 agtaacatat aaaaagctca acacaatgcg agtgttgagc tttttttctt actgttcttt 3724501 gcgaatatgt atatcctgaa tagactgttt cggtgcatga aatctgctct cggcttcact 3724561 tcttgcctcg gcaaaagccc gcgcctccac atgatctttg tagacatcca gctgaatcaa 3724621 atacagcggg cgcactttaa atccatgaat aatggttacc gcccataacg ggaccacaat 3724681 aaaaacaccg ggcagatcgg gcaaaacaaa accaaacgca aaaatgaaaa aataaatgat 3724741 gccgtacatg atccactttc tatttctaac cttgatgcca ataaataaaa aggcaaaaaa 3724801 actggtaatg gcaaaaggca tgaaaataaa cagcatccac cagctatgca gccattccca 3724861 agcggcacct ctttttgtaa ttcccatatt tttctcctcc tatttaccta taataatcga 3724921 ttaggcacac cgcgtcaccc ataaacggga aaaactttct cccttaaaaa tagtgataga 3724981 cggagaacag gtttcttgct atattattaa ttgataatga taatcattac taatctattg 3725041 agatacatag tgggagggtt cttgatgaaa aagaacatat tgctcgtggg catgcttgtg 3725101 ctgcttctca tgtttgtcag cgcttgcagc ggcacggctt ctaaagggag ctcaagcgat 3725161 tctgcttccg aaaaaacaga aatgagaaca tacaaatcac caaaagggaa cgtcaacatt 3725221 cctgcacatc cgaaacgcat cgtcactgat ttttatgccg gtgaattgct gtctgtcggg 3725281 gccaatgtgg tcggctcagg ctcatggtca tttgataatc cgtttttaaa atcaaagctg 3725341 aaaaatgtga aggatgttgg tgatccaata agcgttgaaa aagtgatgga gcttcagcct 3725401 gacttaattg ttgtcatgaa tgaagagaat gttgataaat taaagaaaat cgctccgact 3725461 gttgtcatac cttataacac agcgaaaaac gtagaagaca cagtcagcat gttcggagat 3725521 atcgccggag cgaaagacca agcaaaatcc tttatggctg actttaacaa aaaagcggaa 3725581 gcagctaaga agaaaattgc cggcgtcatc gacaaagatg caaccttcgg catttatgaa 3725641 aacacagaca agggcgaatt ctgggtgttc aatgacaatg gcggacgcgg cggccaagct 3725701 gtatacaatg cacttgggtt aaaagcgcct gaaaaaattg agcaagatgt catcaaaaaa 3725761 ggagagatga aacagctctc tcaagaggtt attcctgagt atgccgcaga ttatatgttc 3725821 attacggatt acaacccgaa aggcgaaagc aaaacactcg acaagctgga gaattcctcc 3725881 atttggaaaa atcttgacgc tgttaaacat aatcgcgtgt ttatcaatga ctttgactcg 3725941 ttctacccgt acgacccgat ttctgtcagc aaacaggtgg atatcatcac cgacatgctg 3726001 atcaaacggg ccgaagaaaa taaaaaataa aaaaacggca cagtcatgac gctgtgccgt 3726061 tttttatgat tcactttaat tttgactgta cggagtccgg catatcttca aacttgactt 3726121 cttcccaagt ctcgacatac tttcctttcg ccttcacctt caaatacgcg ttcttccgaa 3726181 gctctttgcc ggcgaaaaag gtcacttctt cttttttccc ggatgcatta tatccgtcta 3726241 atgtatattc agtaccgccc ggactaagat gtctgccatc tcgatcaatc tgaacataga 3726301 catcttgctg gtgaataaac ggattaaatc tgtctgtaac atcgttatga aaaaagagaa 3726361 gcccgcatat tacggcagca gccgccaaga cggccaggat tgccattgct tttttcatct 3726421 ttgcactccc cttacttgtt catttttttc aaatagcttg accgcaccgc gaggaagaat 3726481 agaagctgaa aaatgaaaaa ccctccgatg gtgagactga gcggccccgc tacatcggaa 3726541 tatccttcca cagccaatgt tctcaaggca aacagtgtat gcatgacggc aatgacaaat 3726601 ggaaagaaga aaagaatcgc caattgtatt gtcacgcttt gcgccatttc tcgctcactc 3726661 aggccgattt tggccagtga acggtagcgc tcccggtctt catctaaatc agtgaacagc 3726721 ctgaaatata agaaacttgc tgccgcgaca aagaatacaa ttgcgataaa caggccgata 3726781 aatagactca ggctcggcag ctgcaccgta tcatagtaag tccccgcttt tgaagcaaaa 3726841 tcagaatgca cgtcgatata attgccgtaa atctcatttt gcaaggattg gctgatctca 3726901 agactgtctt tccaatgatc atagctgtag ccgtataatg acgctttatc accgagtgat 3726961 ttcagctgat caaaggtttg atcattcacc gcgatgatag cattcaatga gatcagcggt 3727021 tttttgactt cttttaccga cagtttttga tcagacagct cccctttttg gttcagcagc 3727081 ttcagctgat ccggcgcttc gtttttgaaa ttgcggtcat acgttcccgg gaaatagaca 3727141 gcctcgtctt ctttcaggcc gttcactttg acatggaagt attttgccgc atccgattca 3727201 ctgatcatgt aaacaggggg aacagtttct ccttcctgat agcgaacata ggaaacatct 3727261 attttgtctt tcgtatacgt aaaaccgtgt gttttcagtt catggtcaat atctttcaaa 3727321 tgagtctgtt cttttggatt gttgctgtaa gataaatact ccatttcata agcggactct 3727381 tccgctccga cggtcgattt gtacattgcg agcacgcctg tcgcagtaaa cgcaaccgcg 3727441 gaaataatgc tgacaataaa gaacaggcgg gcgttgtctt ttagacgata gacaaggtca 3727501 gaaacccaaa tgatgttttt cccgcgcaga taaaaggttt tccacttctt cagcgcgcgc 3727561 agaatccata tgctgctttg gctgaaaaag aaatatgttc cgataacggt gagcagtaaa 3727621 atgataaacg gttcggcccc gtggacattg cctttaagaa ccatgccgta cccgccgcac 3727681 agacaggcga tgccgaataa ggacagaagc acggacggct taggctccgg tttaaccttg 3727741 ccagtgccct ttattaattt gataaccgta tttgatctga caaaaaggat cgtaaactgc 3727801 gataaaaaga aaaataagag cagaaatccg caggccgtaa taccgagcgc tttccaaggc 3727861 atatacaaag gcagcgcgtc catttctaaa atataagcgc cgaccgtaaa gaacgtcttt 3727921 gaaaaaatga atcctccgat aataccggct gcaattgaca tgacgccgat gatcatattt 3727981 tccgcagtaa tgagctttct cagctgcccc ggcgtgatgc cctgcatgag cagaatgccg 3728041 aattctttat ttctcgattt caaaaatgca ttaaccgaat acagaacaaa taagaaagaa 3728101 aaaacaaaga tcatccattc cgcggcggtt aagccttttt tggcgatgtt attcaggtag 3728161 ccttccttta atgccggatg aaacaggaac atcgcaaagg taaagaaaat caaaacggaa 3728221 aaggcgctgc ttaaaaagaa tgcaagatag gcccttttgt ttctcgtgac gtttttataa 3728281 gcgaactgaa gaaaggtcat ttgcgtttcc ccccagcata gacagcacat cgagaatttg 3728341 ttcataaaat acttggcggt tttccccgcg gtaaatctca ttaaacagtt cgccgtcttt 3728401 tataaagatg acgcggcggc agtagcttgc cgaaaccgga tcgtgggtca ccatcaaagc 3728461 cgtgacatga tcatcccgat tcaggctctg caacgtttcc atgacgtctt ttgtcgcttt 3728521 ggaatcaagg tttccagttg gttcatcggc cagaatgagt gacggcttat gaatgaccgc 3728581 tcttgcgatg gcggcccgct ggcgctggcc tccggatact tcaaacgtcc gcttgttaag 3728641 caggttttcg ataccgagct ttgccgcgat gccgtgcagt ttttcttcca ttacagacgg 3728701 cgcttctttt tcaagcgtta acggcagcat gatattttca ccgatcgtca gcgtatccag 3728761 aaggttgaaa tcctgaaaca caaatccgag ctgcttgcgg cggaaatgag cgagctttgt 3728821 ccgcttcagg cgatgcgggt tttctccgtt aatcaggata tcgcctgaat ctggacggtc 3728881 aatcgttgaa atgatattca aaagcgttgt ttttccggac ccggacggcc ccatcaccgc 3728941 cgtgaactcg ccttcttcta ttgaaaatga aatttgcttt aaggcctgat aggacacttg 3729001 tcctttatag gttttattta tatgtttgac ttcaagcata ttcgccatga aaatcctcct 3729061 tatggtttta ttcttgttga tctgggctgc tttcatgtag tgccgggacg ttcaacataa 3729121 aaatcccctt gacataaatc catgttatca aggggaaaca aagcgggcta tgttgttttc 3729181 ttaacgcagc cttacatttt tgtaagaaat gaaaatcgaa ctgatgtccc ttcaccggga 3729241 gacgagctga tgtccaccgt atgattgagc ttatctgtaa tttctttgac gagatggagg 3729301 ccgattcccg tagattcttg gaaacgccgc ccgttttcac ccgtgtaata agggtcaaac 3729361 acccgcttga tgtcttgtga gggaatcccg acaccgtaat ctttgacttc aagcaccgtc 3729421 ctgtcttcat cgcagaagac attcagctca agtctgtcac tcttgcccgc tgaatacttg 3729481 accgcatttg tgaccacttg gccaatcgca aatttgagcc atttggcatc ggtgtaaatc 3729541 tgatgatcat cgcaaacgtt cattttcgga taaacgcgat attgaataaa aaatcgttta 3729601 tagctttgaa taactgattg gagaagctcg gacagggaaa ccgcttcgat tttaaaatcc 3729661 cgttcaaaca ggtcgagcct tgaagaataa agaagcgtct ccagcccgaa ttcaatctgc 3729721 cggacttctt ttttgatttg ttcaaaaacg ggctcatcct cttcttgaat gattaaatta 3729781 atgaccgaca gcggcgtctt tacttggtgc acccattgat tcatatacgt cacccgcgcg 3729841 tcaagcttgg cttcggtctc atggagcttc tggtgctgca gccggatcag ctccatctgc 3729901 ttttcataca gctctgaaca gaacactgaa gaaccgagat acgggatatc cgtcccttcc 3729961 tgccccgagc tgagccaatg atacacgccg cggtctttgt accagcgata ggcaagatag 3730021 cccgccaaaa taagaagctg cacgcccaat atgtaaaaca agtgagaaaa agaatgaaga 3730081 cccgcaaacc agtaataaaa gaagacaaac agcccttgaa ggagaaaaag cagaatcagc 3730141 actgcatgag accggagaaa cagcttcatg actgcgccct cagctggtag ccttcgcccc 3730201 gcaccgcttc aatagaaaca ggcgcattca gctcccgcag tttttttctg agccgcgtga 3730261 tatacacgtt aagtgtatta tcatcgatga atatgtcggt gtcccacgtc ttttccatga 3730321 gacggtcccg actcgtcacc ttttctcccc gctcaagcag cacttccaaa agcttgcttt 3730381 cttttttaga aagctcactt ttttcatcct gaaaacgcag ttcaaaccgt tccacaaaga 3730441 gctgaacgcc ggcatattca accactttct ctccctgctt tgcggcgtac tccccgtacg 3730501 ccctccggat ctggcttttg attttcgcaa gcacaatatc ataagaaaac ggtttttcga 3730561 tataatcgtc tcccccattt tcaatcgcca tcacctgatc catttccccg cttctggcag 3730621 aaataaagat gatcgggctt gtggagtgct ggcggatctg ccggcaccaa taatatccgt 3730681 catatgccgg caaattgata tcaagcagca ccacatcggg cttttcccgc aaaaagacat 3730741 caagaacagc tgtaaaatcc gcggcgacca ctgtttgata tccgtatttt tcaaggtaat 3730801 tctgcaatag tccgcgaatg tcttcactgt cttccacaat catgatttta ttcaaactga 3730861 accactcccg tttcttacac tgctgccatc atcataatcg ttttgggcgt atggacgcaa 3730921 caccgcacaa aaaaaccgcc atctcggcgg tttctggtct ctttagccga cctgctgctt 3730981 agctgcttta ccggctgatc cgaactctct cattttgctt cgcactgtct cttccacggc 3731041 ttcaatgccg ggtgtcaaat agccgcgcgg ttcgtacaga tcgctgtttt cctgaaacat 3731101 gcggcgtgtt tcgtctgtcc acgctaccat acattccgta ttgatattga tcttcgcgtg 3731161 gccgagcgtg atggcttttt tgatctgatc ctgcggaatc ccggatgccc cgtgaagaac 3731221 gaggggaata tcagtcatgc gggagatagc ctccatttcc ttaaatccga gattcggctc 3731281 accctgatat ttgccgtgta cagagccgag ggcggcggcc agcgcgtcga tattggtttc 3731341 tttaacgatc cgctcacatt ccgtgatatc cgcatagcgg accccgccga ccagtccgtc 3731401 ttccattccg ccgaccgtgc cgacttcggc ttctactgac acgccgtgtt ttgcggcata 3731461 atcggtgact tcttttgtca tcgcgatatt ctcgtcaatc ggctgatggg agccgtcaat 3731521 catcactgag ctgaatccgg catcaatggc ctgtctgcag cgttccgcac tgctgccgtg 3731581 atcgagatga agcacgaccg gaacggtaat cgccatgtcc tctattaacg cgccgaccat 3731641 ggcggcaatc gttttaaatc cgcctaaata gtcgaccagg cgatcggaag ccgcggcgat 3731701 gaccggtgat tgctcctttt gcgccgcctg caaaatcgcc ttcgtccatt gcaggccgtt 3731761 gatattaaac tggccaattg catattgctc ccgctttgca tcttcaagaa gctctttcat 3731821 cgatacaaaa gccatattca cccctccttt atccattaca tgctgaagta ttttgatacg 3731881 acatccactg ttgttttttt cgctgtttga atggcttcct cagcagtcag cttatagtat 3731941 tcaggccgga agagctcaac cgaaacaaca tcagagaagc cgatttcctt cagtgctgat 3732001 aagtgggcat ctaagtcaat tgccccttgt cccggccata cacgatcctc atctgttaaa 3732061 aagccgattg ggaaatcttc tgtatcatca atatgataga tgaagatttt ctttccgtcc 3732121 gcctgcttta agctctcaat atttgaaccc attgcatgga agtgaaaact gtcaaggaca 3732181 agcccgacat tgtcacggtt aactgtgttt acaatctcat acgcctgttc aaacgtattg 3732241 accgtacatt gcggatggcc gacaaactca agcgcgattt ttacgccgta cggctccgcg 3732301 atatctgaca gctcagtcag cacgtctaca ctgctctttt tgatctcttc ttttacaatc 3732361 ttctgctctg tcacaagcgg aacggccacc acatatttca caccgagggt tttgcatgtt 3732421 tccatcatgc ctttaaattc agtgatgatc tcgttgtgac ccttttcatc acggttgttg 3732481 aagaaaacga gtgcgtttaa ggcaagcggt ttgatgtggt gggtttgaaa atattccgca 3732541 aggtcatcca atgaatgatc ttttaagtac tccggcagct tatccatagt acggatttca 3732601 atataatcat agccatgctt ttcgcatagt tctaaatcca gtttaaggtt tgagttttcc 3732661 aatgttgtcg cttcattaaa acaaagtttc atgccagact cccccatctg cgttttagat 3732721 atgaagggag ttcggcagga aggctgtcgc catatcccgc cgaactccat gctcagctta 3732781 tgccagacct aattcttctt tcattttctt aagcataaat cggcttgatt catccgctct 3732841 ttcatcgacc caagcaaata cggcattcgt cgcaattccg tcgaacttca tctctctcag 3732901 ttttctgaaa atcgtatcaa aatcaacctc gccttggcca atgtccaaat gctggtgaac 3732961 cgttactttc gcgtcaggcg gattgacgat gtagcgaagg ccatgagccg ctttatgatt 3733021 ataggtatct gcaaataaaa catgtgtgag gcggtcgccg gcttcgtcaa acatggtctc 3733081 gatgtcgcct ttgccgtcat catagaagaa cgtatgcgca gtcgagtaga caagattgat 3733141 ccaatccttg tcaagcgcgc ggatcatatc catcgcacct ttgtgcgttt cgataaaatc 3733201 atatggatgg gcttgaagat tgagtttaat gccttctttt tcaaagactg gcagaagctc 3733261 atccatggat ttgataaatt tttcttcact tgttaaagga tcatattttg aaccgctgaa 3733321 ttcgctgttc atcaaatcca cttcaagttc aaccgcaatt tcgattgccc gtttccagtt 3733381 gcgcactgct gcctggcggc ggtcttcatc gggtcccgcc cagtggtaaa gaggaagaag 3733441 cgatgaaagc ttaacacctg tatctcttaa aaggcgcttt aattgtttga tctttgctga 3733501 atcgactttc ggatatttat aaaacgggca aaaatcctcg cgcggcgata attcgatata 3733561 ttcatagccg agctctgccg ttttatagac catttcctct aaagttaaat catcacgata 3733621 catggatgga tccaatgcta acttcatatt ttcactcctc tgttttttag ttttgaactg 3733681 ttgtaaaaga ttgatagaat tccggttttt ccttcaattc aaccttttct ttttgtccag 3733741 attcctgggc ttttacacac gcgtcagtcg tgacagcagc aatatagccg tcccatgccg 3733801 tcggtccgct gacctcgcct ttcttttgaa tcgaatcaat aaagtcttgg atttccacat 3733861 catacgcagc gacaaagcgt ctctgccaat ccatcaaaat atcagtgctg aatctgcctt 3733921 cttttctcaa gctgatgctt gatggctcgg gaagcttgat gatgccgtct tctccgacga 3733981 tttcacattg aatgtcatag ccgtatttac agttcacata gatttcagca ttgatgacga 3734041 taccgccttt tgtttcaatc acgacgattt gcggatcttt taaatgtgga agcgcgtttt 3734101 ttgatttttt cggatagatg acttgaacgg actcgtagtc atcattgacg agccagtgga 3734161 gcacgtcaat ttcatgaaca agcgtgtcga ctacagccat atccgttgta tagttatctc 3734221 ctacagtcgg gttgcggtgc gcgcagtgaa tcataagagg ctcgccgatg acatgattat 3734281 cgagcgcttc tttcagctgt acgtaaccgc tgtcataacg gcgcatgaag ccgacttgaa 3734341 caaggcgttt gcccactttg atttcttctt cgacaatgcg catgcatcct tcagccgttg 3734401 tcgcgagcgg tttttcacag aacacatatt tctgggcttt aatcgctttc agcacgcttg 3734461 actcatgcgc aggcccccag cttgtcacta aaacagcgtc tacattttcg tctgcaagca 3734521 agctgtcatc attcggataa accgtcgcgt ttaattggta ttgctcaacg accttttgtg 3734581 cagcttcttg attaacatcc gttacagcta caatttccgc gcctgacagc ttgttcgtga 3734641 tacggttaat atgttctttt ccgattgctc cagttccaat tacgccaata cgtaaactca 3734701 ttgacagcca ctccttctgt tggttacatg attttgcttt ctgttccttt ctttacttgg 3734761 ctctgaggag acccgtagag ttcctcttga atttgttcaa gcgacttgcc agacgtattc 3734821 ggcgcaaaga gcagcccgat gatcatactg gccgtcacac atccgagaag aattgcagcc 3734881 atcgttccaa tgccgaaatt ggtgataatc attgggacaa acagactcca aatccctatt 3734941 gaaatacgga caaggaaaaa catcagtcct tgtgcggaag cacgatattg cgtaggaaag 3735001 atttcgctgg cccataactg atagttcgct tgctgcccgg ctccgttatt gatgccgatc 3735061 acgacaataa acaggagcag aatcggcagg ccttcaactg gcagcagaaa cagtgtccac 3735121 ccgatcaccg ccatgaaagc ggcgattcca aatacggttt ttctatattt gtcggcaaag 3735181 ggcatgaaga tcaaggcgac ccccaatcct gtgaagataa acagccccat ttgcaaaagg 3735241 ttggccatgt tggcagatac accgccgacc tgctgataaa tgtatggcat aaagaagccc 3735301 atgaccccgg cggctaggtt ccaaaccaag tacacaccca tcaaaaacag gatgcttttt 3735361 agatacatag gcttgagcaa atcaaaatac gatgtcttat tcaatacagc cggcttctct 3735421 gcctgagctt cctccggctg attttttgtc tgccaggcgt ctgattccgg aagcctgatt 3735481 ctcaggatgt acgtaatcag cgcaatcaca agcagatggg caaatacgat tttattcccc 3735541 aagagtccca agtcaccggc cagtacggag aggagcagta caacgacagc gcccgcggcc 3735601 caagcgactt gtgctacgcc gcaatgcctg gcccgattct tctttggcgc attttccgca 3735661 ataatggtcc atgacgcggt tatgtcagcc cctactgata aaccgataat gatgtaaccg 3735721 cttaacaaca tggggaaatt aaccccgaac aaaaccaaac aaatccctag tgcataaacc 3735781 agcatactat tggtataaac agccttccgt ccgactttat cagccagaaa cccgccaagc 3735841 agcgcgccga cagcggcaga aatcgcattt gcgctcaacg cgccgagcag cccgatttgc 3735901 gtatcggata gcttaaggta actgacccat aatgataaac cggcggagcc tgccacaatt 3735961 gaaccggcat caatatagtt ggccaatgct gccgcgattg tccgtttatt gaaggctgaa 3736021 tctccattgg tattgcccat atgttcattc cccattaagc cagatccaac aactgctgat 3736081 caatatagtt tctcgcaatc aatgcatact ccagcgggtt tgcaacatcg gggtcttgtt 3736141 cagcttcaat gacaatccat ccggaataac tgtgcttcaa cagcagctga tatacttctc 3736201 taaagtcaat gcagccgtca ccgggaaccg taaacatgcc ttttaaaaat gattgccgga 3736261 acgattgtcc ttcgagcctg cattgttcca tgacattcag gcgggcatcc ttaaagtgca 3736321 catgcttaat gcggccgata tgcttctcaa gcatccccat gtaatcgccg tcagaaatat 3736381 acgcatggcc tgtatcatag aggaggtgta catgcgcagg gtctgttcct gccatcaggc 3736441 ggtccacttc ttccgctgtt tggacaccag tgccgagatg atgatgatag acaagcttca 3736501 agccatgctg agcggcaatt tcgccaaggt gattcagccc ttcgcaaagc cgctcccatt 3736561 catcatccgt aaagtgcggc ttctctgtga acacattttt ctccaagctt tgcacgctgt 3736621 acgtttgttc agagacaact gcgacatccg cgtttacttg ctgcaaatac tcacaatgca 3736681 gggtaaatgt ctttgccgct tcaccaagtc cgtcacgcaa aataaaactg ctgaaccatt 3736741 ttcctgcaat gcgtaagttc cgaagcttca gctctttgtt caggatggca ggttcgggga 3736801 aaaagccccc gacctccgtg ccttgaaaac gtgcgacaac gatatcactt aacaaatgct 3736861 gaagtgtatt tcccgctcca atttcaggca tgtcatcatt ccgccaccca atgggagcga 3736921 ttccccacag gatttcattt ttgcccatct atggtgcctc ccctctaata ctgcttcgca 3736981 gattccagct ttttctcttt tgcttcgtat gctttctgaa cgctttcttg ttcagatacc 3737041 tctgccaccc cgacatgcca ccagctgtca tagccgtccg tcattgtttt aggcagcacc 3737101 ttcatttcaa ttaatgttga tacatcctgt ttcttcgcat cctctaacgc agcttttaat 3737161 tcttctactg tgtttgcacg gtaggttttc gcgccgtatc cctcagcgac tttcgcgtaa 3737221 tcgacattca ggatttggtt gtcatctgtg cggaactcgc aatagtagct gccgctgccg 3737281 tgatccattt gcaggttgtt gatgcatccg aatcctgagt tgtcaaagag cagcacattg 3737341 attttcttgt tgtactgaat cgccgtgatc agttcagaat gaagcatcag gaagctgccg 3737401 tctccgacga ttgaatacac ttctctgtca gggtgggcca gtttaagacc gagtgtcccg 3737461 gacacttcat agcccatgca agaatatcca tactccaggt gatacgtatt cggaacatta 3737521 gaatgccaca gacgctgcaa atctcctggg agtgagcctg ctgaacagat gatgacgctg 3737581 tcttcaggaa tcgtctcgtt gattgtcagc aatgccgttg tttgcggaag ctccgtattc 3737641 aacgcgtcag catattcatt caggacctct tgagaaaagt gatttttgat ttccggatca 3737701 aatgcttccc gcttaaacgt cactttgctg agacgctcgc gttcagctag ccattcgtcc 3737761 ttcagctccc ggatcgttgt gccgaactcg ctctcatagc cttcaagcaa gccgtgcagt 3737821 ttgccaagcg tcactttcgc atccgccacc acttggaatg catcaagttt atacgcctgc 3737881 attcggctga cgttaatgtt caaaaacttc gctttatcaa aatcaaaagc ggtcttagag 3737941 gatgtcgcaa aatctgtata ccttgtgccg atgccgataa tcaaatcagc ttggcgggcc 3738001 gctttgtttg ccgcaagtgt acctgtgatg cccattccgc caaggttgtt cgcaaaatct 3738061 gcctcaacgg tagactttcc tgcctgcgtt tcaactaacg gaatgttata ggcttcagaa 3738121 atggcaacca attcatcgcg cgcaccggaa tattttgcgc ctccgccgac gagaatcaca 3738181 ggttttttgc tggatttaat cagctccgcc gcaccttgaa gctcgcgctc gctcggctgc 3738241 atgcgatcaa tatagtgaac ccgtttgacg aagaaacttt catcaaaatc gtatgcttcc 3738301 ccttcaacat cctgagaaat acaaatcgtt gccggacctg cttttgccgg atcagtcatg 3738361 acttcaaacg cgcgcagcaa actgctcatc agctgctcag ggcgcgtaat gcggtcccag 3738421 tatctcgata caggcttcaa tgcatcgttt gtcgtaatcg ccgcactgta ttcttgctcc 3738481 atttgctgca gtacagggtc tggctgtctt gtcgcaaatg tgtctgccgg aatcaagaga 3738541 actgggatat tatttgccaa tgcagtgccg gctgccgcca ccaagttagc cgctccaggt 3738601 ccgacggatg tagacaccgc atatattttt cttctcagca tttgcttgct gtacgccatg 3738661 gccgcatgcg ccattccttg ttcatttttc ccttgataga ctttcaaatg gcctgcatcc 3738721 tgctcaagcg cctgcccgat ccctaatacg tttccatgac cgaaaatcgt gaagatccct 3738781 tcgacaaaag gctcttcctt tccatctaca tggatgtact gctggtttaa gaatttaatc 3738841 agcgcctgcg cagttgttaa gcgaattttc ttacccacaa acgatcccac ctttactcga 3738901 tctttttcaa ttatgactgt gcttcaataa gctgttcgat ttcttccgca gtcggcatcg 3738961 cttctgacga actgtgcttg ctcaccacaa tggaggctga agcactgccg tatttcaatg 3739021 ccgtttcaat gtcttttccg ctgacaaggc catagataaa ggctgacgca taggagtcac 3739081 cggccccaaa ggttttcagc acttttgtct tgtacgcttg agcgcggaat acctcgccgg 3739141 atttgctgta tgcgtaagag ccttcgacgc cgtgtttgat gacaacgagg tcggctgaat 3739201 ggccaaataa atgattgacg gattcttcat tgcttccgcc tgtgcggttt tccatcacat 3739261 caaattcatc gcgtgtgccg atgacgatat cagactgctc ggcaaccaaa gaataataaa 3739321 cggctgtttc atctgatgac tgccacgtat atggccggta atccagttcg aataccacct 3739381 taacctgatg ctttttcgcg tattgaacag cttttaacac cgcttcccgt gacgggcttt 3739441 tggcgagcgc tgtcccggag acaagcagca ttttcgcatt tgcgatatag tcctcactta 3739501 cctctgaagg ctcaagataa agatccgcca catcatcgcg atacattaag atgctgcatt 3739561 cttcagggct gaggatttct gtaaatgcaa ggcctgcttt gtgtccatct tgatcaacaa 3739621 tcatctgtgt agtatccacg ccggtctttc tcatatagga ctctatgaat cttccatgct 3739681 ggtcatccgg aattttgccg atgaagcccg cttttaagcc aagcttcgcg ctgccgatcg 3739741 cgatattcgc aggtgaaccg ccgacatatt tcgaaaatgt catcgtttct tccattgggc 3739801 ggttgtattc gactgcgttc agatcaatac atgcccggcc gatggcaaca atatcaaaag 3739861 ccttctcttc attgaatgta tacttcatcg taaacagcca ctcctcactt gttagcgttc 3739921 taaaatccat tcatgcgccg ggtcgttata aaacttccat tttcgcgtcg gccctgccat 3739981 gacatttaaa tagtaggatg tgtatccgtc cggaacgcct accgggtggt atcccgcagg 3740041 aacgatgaca acgttttcat ttcccacagt cattgtctcg tcaatagaac ggtcatctgt 3740101 gtatacgcgc tgaaacacaa agccctgtcc cgggtctaac tcatggtagt acgtttcttc 3740161 taagaaagat tcttccggca agttgtcttg gtcatgtttg tgaggcgggt agctggacca 3740221 gttgccgctg tctgtataga cttcaactac taatagactg ttagctgaag ggtctgaatc 3740281 cggaagaatg ttatgaacag tacgtttgtt tgaaaattgc ccgcgatgct caattccgtt 3740341 gtcttccgct ttgatcagct ttgtcggaag ctgcttttcc gatggagaat agcaaagcgc 3740401 cactcttgcg tcgctgaccg ctgtgatctc aaatgcacgg tcatttgaaa tatagacgct 3740461 gtctgtcggt tttcgttcaa atacgctttc gcgcgtgccg atattctcaa aagtcgactc 3740521 atgatctgtc actgtaattt tccccgttac cgccacaata cagatttctt gttttttcaa 3740581 ttcttctgta tagcttgaac ctgatgcaag atctaacact ttaaactcta cataagtgag 3740641 atcagagttg gatgtcgtta cttcgtgcac gagtttgacc ccattagaca cttcatgcga 3740701 ctgcggctta cgcaacaaat aactcataga gaagccctcc tctttctatt ggcagaatga 3740761 gtccgaacag cgcacatgga cgccgttcgg ctgttcgtcg tttagttgaa atcaggtgcc 3740821 ggatatcttg ccgtcaccac ttttttacgt gtatagaagt cgacgctgtc ttttccgttc 3740881 gcatgcagcg ttccaaagaa tgaagatttc cagcctgaga atgggaagaa cgccattgga 3740941 gccggcacac caaggttgat gcctagcatt cccgcatcaa tgttttcacg gaagtagcgg 3741001 attgcgtttg agttggatgt gaacaagcag gcgccgttcg caaactcaga cttattggcg 3741061 atttcaatcg cttctttcag gtttttcaca cggatgacag ataagaccgg agcgaaaatt 3741121 tcatctttcc agatcgtcat ttctgttgtg acattgtcaa agatcgtcgg gccgacaaag 3741181 tagccgtcgt cagacacatt ttcacgtccg tcacatacga gtctggcacc ttcttcaaga 3741241 cctttttcga tatagctgag cgtgcgcttc ttgttgtctt cgcgaatcac cggtcctaag 3741301 aacacgccgt catcaaggcc gttaccgatt ttaatgtccg ccactttttc ctgcagcttc 3741361 gccataaatt catcggcgat tccttcttca actgtcacaa ccgcacaagc catgcagcgt 3741421 tcaccggcag aaccgaaggc agctccaacg atgtttgtaa ccgtgtcttc aagattcgca 3741481 tcgttcaaga caatcgtatg gtttttcgcg ccagtcagag attgaacgcg ttttaagttt 3741541 tcgcttcctt ttttgtagac gtattcgcct actggcttgg agcctacaaa tgaaatcgct 3741601 ttaatttcgg gatgctcgag gatgccgttc acaacgtcat gcgcaccgta tacgacgttg 3741661 aacacccctt tcggaaggcc cgctttttca aaaagctcaa ccaatttctc tgttaacagc 3741721 ggagtccgct cagatggctt taaaataaat gtgttgccga gcgcgatcgc catcgggaac 3741781 atccagcaag gaaccatcat cgggaagttg aatggcgcga ttccgccgac aactccgatt 3741841 gggtaacggt agttcgccgc ttcaacgtcc gttgcgatgg aagcaagtga gtcacccatc 3741901 atcagggaag gtgctccagc ggcgaactct acgttttcaa tcccgcgtcc cacttcacct 3741961 aaagcttctt tcgtgttttt tccgttttca atggtaatta gatgagcaag ttcttcttta 3742021 tgctgagaca gcagctgctg gaagttaaat agaattctgg cgcggcgagg aaccgccacc 3742081 tttgaccatg ttttaaatgc ttcagccgct gtttgcgctg cgtaatcaat atcctctttt 3742141 gtagaaatcg gcacttggca tagcacttct ttcgtcgccg gattgacgac atcttcatat 3742201 tgatctgttt tgctttcaac ccattcaccg ttgatgtagt tttttaattt tctgatttct 3742261 gccattctta ttgcctcctt cattagtaaa cacatacact tgtatggatg gttccggata 3742321 gattcatatc aatatccact tttcagcaag ccaagaatta aacgctttca aaaacaccaa 3742381 aaaaataaat ggcggatgca tatttacata caagcaacca tttcatgcac aacaggttac 3742441 tttttggtca tttcttggtt atattctaat cgcataatac ccataagtca atcataaaca 3742501 ctacattttt tcattatttt tattatatta atcttttaat caagtaagag aagtaagaga 3742561 aggccgtcca atcttgcaaa agatatacac cgatgttatc atttttaagc aactattgat 3742621 taacttttgg tttttattat atatttatgt tacgtaaaga ttcaagaagg agttttttat 3742681 atgaaactga tgcggattca ggaaatggag gagtacattt tatcgcatgg cactgtttcc 3742741 ttagatgagc tgtgccaggt gttcaatgtc tccaaaaaca cagtcagacg tgatatcaac 3742801 aagctaacag aaaagggtgc gattgaaaaa gtatacggcg gcgtaacatc tattgaaaaa 3742861 accgcattag ttccttttga aaatcgcacc attcagcacc aggatgaaaa aacaaaaatc 3742921 gcccattatg cttcccgatt tattgaagat cacgatttgg tcttcattga ttcaggaacg 3742981 acgacaaagt ctattcttga tacgcttgat ccagccaaaa atgtcaccat cttaaccaac 3743041 agtttagaca ttatcaatgc ggcgtcagct ttgaagaata tcaacttaat cattatcgga 3743101 aacaactata agagaaaaac ccgctccttt gtcggcatgg acgacccggc tatgcttgat 3743161 aagtacaata tcaacaaagc ctttatgtcc gctaccggaa cgacgctgac tcacggattg 3743221 accaattcgg atctgctgga gtatgaaatt aaaaagagga tttcagaaaa agcaaaagaa 3743281 gtgtatctat tggctgacca ttctaaattc ggaaaatcaa cgcttctgac gtatgcaccg 3743341 tttgacaggc tgcattgcat tgtgacctct cagccattag acgacgagta cacgcagtac 3743401 tgcaatgagc atcaaatcgg cattcatctg gcctaacgtt tacaatagtg ttgagagtct 3743461 atcatccatt ttattctagg aggcagatca tgaaaaaagc gaagctcgga aaatcagact 3743521 tgcaggtatt ccctatcgga ttaggaacaa atgctgtcgg aggacataac ctctacccga 3743581 acctaaatga agaaaccgga aaagaattgg tgcgcgaggc gatccgtaat ggcgtgacaa 3743641 tgttagacac cgcttacatt tacgggatcg gccgttccga agaattaatt ggtgaagtgc 3743701 tgcgtgaatt caaccgtgaa gatgttgtca tcgcgacaaa agccgctcac agaaaacaag 3743761 gcaatgactt tgtctttgat aattcaccag attttcttaa aaaatcagtt gatgaaagcc 3743821 tgaagcgctt gaataccgat tatattgatt tgttctacat tcacttccct gacgaacata 3743881 cgcctaagga tgaagccgtt aacgcgctga atgagatgaa gaaagccgga aaaatccgtt 3743941 ccatcggtgt atccaacttc tctttagagc aattgaaaga agcaaacaaa gacggtttgg 3744001 tagatgtatt gcaaggcgaa tacaacctgt taaaccgtga agcggaaaaa acattcttcc 3744061 cgtatacgaa ggagcataat atttcattta tcccttactt ccctctcgta tcaggtttat 3744121 tggcaggaaa gtatacagaa gatacaacgt tcccagaagg cgacctgcga aacgaacagg 3744181 aacacttcaa gggtgagcgt ttcaaagaaa atatcagaaa ggtcaacaag cttgcgccga 3744241 ttgccgaaaa acacaacgtg gatatccctc acatcgtatt ggcctggtat ttagcaagac 3744301 cggaaattga tattttaatc ccaggagcaa aacgtgccga tcagctgatt gataacatca 3744361 aaacagctga cgtgacgctt tctcaagagg atatttcatt tattgataag ctgttcgcat 3744421 aagaagaaaa cagccttctc caatggagaa ggctgttttt ttgtgcgata aattcctaaa 3744481 taactgattt tgaagcaaaa ccttacaaaa tgagccataa atccgataaa ataaaggtag 3744541 tttatctcag aaagaaagtg attgagaaag caaaagtatg aaacgttcat atcatctagc 3744601 tcatatgaaa taaagctgac ccagcttctt ttatttgctg gtcagaatag cggaccgttt 3744661 cgatggtcta tggaggaaac agaatgaaac ttaaatatgt aaaagcctta gttgcagtaa 3744721 ccgttgcttt aggtgtactg ctgccatcaa cgatttctca tgcaaagagc tttagcggcc 3744781 gctcatcatc tagttacagc agccgaagtt caagctcatc atacagcgga agctataaat 3744841 caagcccgaa atcaagctac agctcaggat caagctcttc tagcaaaaaa tccaagacgt 3744901 ctgacgattc atcatcatcg atttcgctta aaaagaagcc ttcggaaaag gcaagttcat 3744961 caagctctaa aaaatcgtca ggcacctttt ccggcgctac atcaaaagta accggaaaga 3745021 catacagcgg aaaaacgtct aaagcctatg ttggcggacg ttatgtttca gtcaatcatt 3745081 actatcacgc aggtttcgcg ccatcaggat ggtttggata ttatagcgga tttacaatgg 3745141 gtatgttcat gatcagcatg atgcacccat ggggttacac ctatcatcca gtcggaggcc 3745201 ccggttatgt ttcttatggc gcttcaccca ttgcctggat cgttgatatc atcgctttga 3745261 ttattatttt aatcattgtc atcgcattga ttcgcgcatt taaagcaccg aagacgtaca 3745321 gaaggagatt ttaggcaatg agattaatat taaatgagca agaaattgta gacggaattt 3745381 gcgtgtatat ttccaatgaa gaagatatct accctgaaga cgttgaagta aaagaactat 3745441 cgtacaacaa gcgtacaggg ttcttcgctg aagctacatt tggcctgcac cacaagcagc 3745501 ttatgtcaga tgacatttca gaaggcatta ttcagttctt agaggaatac cacaacttca 3745561 atccggacgt taccgtcgtt gaattgcaat ttgataagaa aaaaggcttc tccgccttgg 3745621 tttttgtcaa cgaagcagaa gaataaaaat gtcttaatca aaccttactc cgcgcgggta 3745681 aggttttttt aatggtttct ctgagcataa agttatttcg tttttcctaa actcagcgga 3745741 tctgtgatca tctcttttgg ctataaagtt tccgtttttt caaaacaaat gtttcaaatg 3745801 agataggaaa tgggtactaa tctattaact ttgttacata tttttagata ctcattggct 3745861 caacaactga ggaggagaca tttgtgaaga aagacacaag gaaatatatg atctactttt 3745921 tcggcgcttt agggggactg ctatatggtt acgatacagg tgttatctcc ggagcactcc 3745981 tgtttatcaa taacgatatt cctttaacga cattgacaga aggattggtt gtcagcatgc 3746041 tgctccttgg cgcgattttc ggttctgcct tgagcggcac atgctcagac cgctggggca 3746101 ggagaaaggt tgtatttgtc ctttccatca tttttattat cggtgcgctc gcttgcgcat 3746161 tttctcaaac aatcggcatg ctgattgcat ctagggtgat actcgggttg gccgtcggcg 3746221 gttcaacggc acttgtgccc gtgtatcttt ccgaaatggc accgacgaaa attcgcggga 3746281 cactcggcac aatgaacaac ttaatgattg tcaccgggat tttgctcgcc tatatcgtta 3746341 actacctgtt cacaccgttt gaagcgtggc gctggatggt cggtctggct gcagtgcctg 3746401 ccgtgcttct attaatcggc atcgccttca tgccggaatc gccaagatgg ctcgtgaagc 3746461 gcggcagcga agaagaagcg agacgcatca tgaacatcac tcatgacccc aaagacatcg 3746521 aaatggaatt ggcagagatg aagcaagggg aagcggagaa aaaagaaacg acacttggcg 3746581 tgctgaaagc caagtggatt cgccctatgc ttctgattgg cgtcggcctt gccattttcc 3746641 agcaggcagt cggcattaac acggtcatct actacgcgcc aaccattttt acgaaggccg 3746701 gtcttggcac atcagcttcg gcgctcggca caatgggaat cggcatcctc aacgtcatca 3746761 tgtgtatcac tgccatgatc ttaattgacc gtgtcggccg caaaaaactt ctgatctggg 3746821 gaagtgtcgg catcacactg agccttgctg ctttatcagg cgtgctcctg acactggggc 3746881 tttccgcatc aacagcgtgg atgacagtag tctttctcgg tgtctatatc gtcttttacc 3746941 aggcgacatg gggtccggta gtgtgggtgc tcatgcctga gctcttcccg tccaaagcac 3747001 gcggagccgc gacagggttc acgactttgg tgttatcggc ggctaacctg atcgtgtcgc 3747061 ttgtcttccc gctgatgcta agcgcgatgg gcatcgcatg ggtctttatg gttttctcag 3747121 tcatttgtct tctctcattt ttcttcgcgt tctacatggt accggaaacc aaagggaaaa 3747181 gcttggagga aattgaagca agcctgaaaa aacggtttaa aaagaagaaa agcacccaaa 3747241 accaagtgct gaatgagcgt acattataaa aaaaggaatc gtctccttat gagacgattc 3747301 ctttttctgt ttacaccatg accttgcaaa tattgttcgt aaattccaca gggtcctgaa 3747361 tcggcaggcc ttcgatgagg agcgcctgat tgtacagaag gtttgtgtac aggctcagct 3747421 tctctttatc ttgttcaaac gcgtcctgca gtgtttggaa tacctcgtga tttgggttga 3747481 tttccagcac tttttccgcc ttcacatttt ggctgtcagg catcgcattt aagatttttt 3747541 ccatctcaat tgtcacttcg ccgtcagcag caaggcagac tggatgtgat ttaagccgtt 3747601 ttgagattct gacgtttttc actttgtctg acagaatgtt tttcatttcc tcaaacagat 3747661 ccttatactt gctttcctct tcctcggact gcttttgatc ctcatccgtg tctatgccaa 3747721 ggtctccgct tgatacggac ttgaattctt tttcctgata agaagccagc attttaattg 3747781 caaactcatc gatgtcctca gtaaagtaga ggatttcata gcctttgtcc gccaccattt 3747841 ccgtttgcgg cagtttctca atgcggtcgt aagaatcacc ggtcgcgtaa taaatgaatt 3747901 tctgctcctc tggcattctg gaaacatact cgtctaagct gaccagtttt ttctcttttg 3747961 aagagtagaa taagaggaga tccttcaatt gatccttatt cgcgccaaaa tcattgtaca 3748021 cgccgaattt cagctgtctg ccgaacgact tgtagaacgt ctcgtatttc tcgcggtctt 3748081 ttttcaacag gctttgcagc tcgcttttga ttttcttgct gatgtttttc gcgatcagct 3748141 tcagctggcg gtcatgctgc agcatttctc tggaaatatt cagcgacaga tcctcagaat 3748201 cgaccatgcc cttcacaaag ctgaagtggt ccggtagcag gtctgcgcac ttattcatga 3748261 tcagcacgcc attggaatac agctccaagc ctttctcata ttccttggaa tagtagtcaa 3748321 acggcatgtt ttcagggacg aatagaatcg cgttgtagcg aaccgctcca tccacgctga 3748381 tatgaacgtg tgtcagcggt ttatcaaacc cgtaatgctt ttcagcatag aatttttcat 3748441 aatcctcatc tgtcagctcg cttttgtttt ttctccagat cggcaccatg ctgttgaccg 3748501 tctgctcttc ctgcacctct tcaaattcat tttcgctgcc ttccttcggc ttattaatgg 3748561 ttgtatccat tttgatcggg tagcgaatga agtcggagta cttcttgatg atcgctttta 3748621 aacgatattc ctctaaaaac tcgtcatagc tgtcatcttc tgtgttctct ttgattttca 3748681 ggataatgtc tgtaccgaca gaatcctttt cacacggctc aatcgtatag ccgtctgcac 3748741 ccgcagactc ccatttataa gcctcttcgc tgccaagcgc tttactgatg actgtcacga 3748801 catcggcaac cataaatgcc gcgtaaaaac cgacaccgaa ctgcccgata atgtcatgtc 3748861 cgtctttcag ctcgttttcc tttttaaacg cgagggaacc gctttttgca attgttccaa 3748921 gatgctgttc aagctcatcc tttgtcattc cgatccccgt atcagagatg gttaatgttc 3748981 tcgcatcttt gtcagctgcg acctttatgt agtaactgtc tttatcaaac gtaagcgcat 3749041 cgtccgtaag cgctttgtaa tagattttgt caatcgcatc actcgaattg gagattaact 3749101 cgcgcaggaa aatttctttt tgggtataaa tggagttaat catcatatcc agcaagcgtt 3749161 tagactctgc tttaaactct tttttcgcca ctcttgatcg ctcctttacc attatgtaaa 3749221 cccttttcag catctattta tcacataaga tgacaattgt caattagatt gatagatgca 3749281 tatatatgta aatttaacat tagttggatt tgttttcact ctttttctca ctcattctca 3749341 taaaaaagag aggcttcatc atcctctctt tttttctgtg tcattccaac ggccaaactc 3749401 ccgcttcatc catatatgca ccgggtagaa aaacaaaccg aacggtatca aaaacaaaag 3749461 attatgccat gaagcattca gaaatgcgct tgcagtcacc gggaacgtaa tctcttgcaa 3749521 taaaaaagag atgacagtca gcacaacaaa tgcagatgga atggtcacga tgcaataaaa 3749581 cttgagctcc ttcttatgct gtaccttcaa acatacaaac ctcccaacaa tttctaattc 3749641 atcttaacat atgctggcct ttcttttctc gcatgtttat cactgcacat agcgggaaga 3749701 caaatagaaa aaggaggtct cgtatcatgg gaagacttga aaacaaaaca gcagttatca 3749761 caggcgccgc gacaggcatt ggtcaagcga cggcggaggt ttttgccaat gaaggcgcgc 3749821 gtgtgatcat cggagatatc aataaagatc aaatggaaga aacagttgac gcaatcagaa 3749881 aaaacggagg acaggccgaa tcctttcacc tcgatgtgtc agatgaaaac agtgtgaaag 3749941 catttgctga tcaaatcaag gatgcatgcg gaacgattga tattctgttt aataatgccg 3750001 gcgttgatca ggaaggcgga aaggtgcacg aatatccggt tgacctgttt gaccgcatta 3750061 tcgccgtcga cctgcgcggc acattccttt gcagcaaata tttgattccg ctcatgctcg 3750121 aaaatggagg ctccatcatc aacacctcct ccatgtcagg ccgtgccgcg gaccttgacc 3750181 gctccggcta caacgccgca aaaggcggta tcaccaacct gacaaaggca atggcaatcg 3750241 actacgcacg aaacggcatc cgcgtcaatt ccatttcacc gggcacgatc gaaacaccgc 3750301 tgattgacaa attagcaggc acaaaagaac aggaaatggg cgaacaattc cgcgaagcca 3750361 acaaatggat cacgccgctc ggacgtcttg gccagcccaa agaaatggca acagtggcac 3750421 tgttcctcgc atcagacgac agctcatacg tcacaggaga agacatcacc gcagacggcg 3750481 gcatcatggc gtacacatgg cctgggaaga tgctgattga ggagaaatgg aaggaagaaa 3750541 cgaaataaga gagggagccc cctctctttt tgtcttttaa agcaatacaa ccttatattt 3750601 cttcacatcc aaaaactgca aaaactccct cgccagcact tcaggcggat gcgcctttcc 3750661 ttcatccagc cgatacaaaa gcaacccgat aatcattgcg gatacataat gggcataaag 3750721 ctttttctct gcgtgaatat cagtttgctg atgcagataa aacgattcca gcgctttgaa 3750781 catatcaggt atcacatgag gaacacccca ttcccgattg agaaaatgga caatgggcat 3750841 gtttgacaaa gcagaaagca gaatggcgag cgccttctcc gcttccttta aggaaaattc 3750901 attcgggctg gaggcaatcg tcaggtgatc aatgatctcc gcacatgatc gctgtatcat 3750961 ggtttggagc aattcctcct tattggcata gtgatcataa aaggttgcac ggcggatatt 3751021 gcttttacgc gtaatatctg aaatcgtgat gcccgcgtag tcttgtttct ccgccaatac 3751081 atccagaaat gccttctgca gcgcctctct cgttcgaacc acccgcctgt cgatttgctt 3751141 ctccttctct cgctctcctg gcacagcttt tccaaacagc caataaaacc gcttttgaga 3751201 aacaagctcc cataccttct ggctgatggc ttcaggagac gcggccgcat cctcattcag 3751261 ccaatacagg ataatcgcgt acgtgtacaa ggcccgataa tgtccataaa tgtcccgttc 3751321 aatcggcgtt aaattcacat ggatcggagc cagcagcaca tcctgctgaa acacatcctt 3751381 aaaaaaacga tgaaaatgtc ctctgttcat catcacagaa aaaaaggaac gatgctcatg 3751441 aacaaaggac agcgtcggat gcaccgtttg ccgttttttg ttcaaatgaa gggtatccat 3751501 atgactgaag gcgtcaaaaa gcgctttgcc cagtccttcc ttcatgtctt cgatcacatc 3751561 ctcaatgatt gaaaacttat cctcataata aaggtagagc gatccgcggc tcactttggc 3751621 cttctcagcg atttctttca ttgtgatgtg ttgaatatct ctatctttca ataaagccag 3751681 cagcgcctct ttcacttgag cttcggcaga ttccggcaca aaagacacct ccaatcatta 3751741 gacagatctt agatatatgt acggtaacgt atagatggtt caccgttgtc tttcttacag 3751801 aaaaggtacc accttataat aggtccgaga aaagaagaaa gcaaatgagg gggattttac 3751861 aatggaacag caagtaaagg acgacatcca gcgtgtcttt cagcttcaga aaaaacagca 3751921 aaaagccttg cgcgcttcaa cagcggaaca gcggagagaa aagcttcaac gctttttaga 3751981 ttccgtcatc gcccatgaag aagaaatcat cgaagcgatc cgcaaagacg tccgcaaacc 3752041 atatcacgaa gtcaaaaaag cggaaatcga aggaacaaaa aaagcgatta gagataatat 3752101 gaataacctg gaacaatgga tggcgcctaa agaagtcggt tcatcgttaa gccctgacgc 3752161 aaacggaatt cttatgtacg agcctaaagg cgtcacactc atcctcggcc cgtggaacta 3752221 tccgtttatg ctgacgatgg cgccgcttgc cgcttctctc gcagccggaa acagcgcgat 3752281 tgtgaagctg tccgatttca cgatgaacac gagcaacatt gctgctaaag taataagaga 3752341 cgcttttgat gaaaaagaag tcgcgatttt tgaaggagag gttgaggtgg caaccgaact 3752401 acttgatcag ccgttcgacc atattttctt cactggaagc acaaatgtcg ggaaaattgt 3752461 catgacagcg gctgccaaac acttggcatc tgtcacactt gagcttggcg gcaagagccc 3752521 gacgatcatt gacagtgaat acgatctgat ggacgcagcg aaaaagatcg ccgtcgggaa 3752581 attcgtaaac gccggccaaa cctgcatcgc acctgattac ctgttcatta aaaaagacgt 3752641 tcaggacagg ttcgcgggga ttttacaaac agtcgtcaac gctggattta tggaggatga 3752701 tcatacccca gaccgcagca aatttacgca gatcgtcaat gaccgcaact tcaaccgcgt 3752761 caaagatctg ttcgacgatg ccatcgaaag aggggcggaa gtggtgttcg gcggcgtatt 3752821 cgatgccagc gaccgcacga tctcgccaac cgttttgaaa aacgtcacgc ctgacatgaa 3752881 aatcatgcag gaggaaatct tcgcatcgat cctgccaatg atgaactatg aagacatcga 3752941 cgaggtcatc gattacgtaa atgaccgcga taaaccgctt gcactttatg tgttcagcaa 3753001 aaaccaagat ctgattgaca acgtccttca gcacacgaca tcaggaaatg ccgccatcaa 3753061 tgatgtcgtc gtccatttca gtgacgtcaa cctgccattc ggcggcgtca acacaagcgg 3753121 aatcggctcc tatcatgggg tatacggatt caaagagttt tctcatgaga agggtgtatt 3753181 tattcaggcc gctgaataat cgcatgatca aaaggcgctt ccttagagga gcgcctttta 3753241 ttgtaactcc ttgaccaaaa gcaattcatc acggataggt attttattat ctgccagtaa 3753301 aggaatttcg ggcttcatct ttctggccgt ctcgactgca ttcacaaata gtcgatccaa 3753361 ccggtaccct ctcttctgat aaaacgctaa tgcatgaata ttatcattgg ttgtgatcag 3753421 ttttatttgt ttgatatttc tctctctgca tgcttcctcg gctttctcta gcagagctgt 3753481 tccgatccct ttattctcaa tgacactatc cagcgaaatg atttcacagg catcttcttc 3753541 aaatatgtat gtaataaggc caacaatctg gttatcatcg ttgagcattc cataaccatc 3753601 taattcatcg cagttataaa taccgctaga aataaccatt tgcggactgc cccagtgttt 3753661 ttgaaaaaac gcggaaacaa gatctttagg tacctggcat gtcggaataa tattcatatt 3753721 ttcctccttt tagctgaaca aaaataagag aattaacaac ctattttatg tcattaatcc 3753781 ccttatctag tatttactag aacttataac ttgtcaaaag ctgtctgaat accaattgcg 3753841 tggattgata aggatcaaaa tctgaatcct gagattggaa gatttgctct ggggtcaatg 3753901 tctctgcgtt ctctgataac gtttgaatca gactttccaa atatccattt aactctgatt 3753961 tggacgattc atgtagggat tgatgattta cagcgagttc tctaaatctg ttatcactga 3754021 ttaatttttt tcgaagagct gctagcatca agtcaagcca tgcaggctgg ccaaatgtaa 3754081 tatttaaagc taacgttgct tgatcagatt tggtggagtg ccataaacct cttggcaaat 3754141 acagcatggt tcccggtgtt aaattaacga tttctgcatc tggcagatcc tcttttggcg 3754201 gatctccttt ccaatatgac tgtaaatcat caggatagta aggagcctct gataaatcat 3754261 agtgctgcat tggattgctc acattttcat tcttggcaag cttccatgtt ttctcacctt 3754321 gaatttgaaa aatcaagttg gtgtaggcgt caaaatgggc tttgaatccc ccgccatttt 3754381 tcgccgcgta aacaatggct ttggaagaag tacccgcagg cagtcttaat tccgctttga 3754441 gtttttctat ccaccttctg acttggggaa taaataggtc ggtgaaatca aactctaatg 3754501 cagccccttt ttcataccac tctaaagcct ctgcaggtga cacaagaaat ctgtctgtga 3754561 tcccttcaga ttcttcaatc acagcatcac caacgaccat gactggatta ttgtagatag 3754621 ccaatacgtt ttctagcgtt ctaacctttt caaaccccgg tatgcttgta aatctctcca 3754681 cttctcctct ggctaccaaa ggttttacag gccaatattc ttctaaaaac tcactcatcg 3754741 ttacaggact gatgatagac tccaaaaccg attcggttac agcactcata ttatccctcc 3754801 caaaaaaagt aacttcacca caaagatata acattttttt ctaaaagtaa atattgacag 3754861 aattatcaga ggattataat atttagttgt gcgtgatagc ctattttttt acaaggaagg 3754921 agggaaaagg atgaaaaagg cttataagaa acctcgtctt tttgaactgc gccgtgctgt 3754981 agcagctggc ggccattaat ctcatatagc atttgacatc tagtactcta ttttaggagg 3755041 gatgctcaat gaaaaaagct tataagaaac ctcgcctttt tgaactgcgc cgtgctgtag 3755101 cagctggcgg ccattaatct catatagcat ttgacatcta gtactctatt ttaggaggga 3755161 tgctcaatga aaaaagctta taagaaacct cgcctttttg aattgcgccg cgctgtagca 3755221 gctggcggtc attaatctta tccaaaacga ttaacgtttg aggctatcac gccaacttga 3755281 taaggaggat gctgaagatg attacggctg aagaatgcag aacgtacaaa gaatttgttg 3755341 atctttacca atcctatctt taccccttgc ttggcgccag actgtcccgg atgtattccc 3755401 ccaaaaacaa agtcattatc gatatgggca caggtccagg ttatttaagc attcagttgg 3755461 ctaaaagaac aaatgcgcac gtgcatgctg tcgatattaa cccggccatg catgaaatcg 3755521 ctcaagaaga agctaaaaaa agcggagtaa gcagcctgat ttcatttgat ttggaagatg 3755581 tccaccattt atcttacgct gaccaatatg ctgacttcat cgtctcctac tcttgcctgc 3755641 atcattggga agacgttgtt aaaggactta aagagtgcta tagagttctg gctccgggcg 3755701 gaaaaattgt cattttggat acatttaatc cccaaggaag ccatttagag attatgcgaa 3755761 aacaaatcaa agaaccggaa tacttcaggt ttgtaagaga ggcatttgaa gaaagttatt 3755821 cctttgaaga cattcaccag tttgttcagg atgccggcat tcccaattat tcattagaaa 3755881 cctttcactt tttaccggag gattttatag aaagcttaga tgagctggag gatgctcccc 3755941 tgtgggaaca aaatgatcaa agtactgatc atgaaattga gtctgtcaca tggatgttaa 3756001 cgatagaaaa agaaaaggaa ggtgcattgt aatgatcaat gaatcaactg ttttatccaa 3756061 aaatccagaa atgccatcaa gaaaatattt gaaaagcatt attatagagc cgggcatcac 3756121 tttaaatgaa atggcatcag atatttataa ccatatcgac ggcaaggtca gcatacatga 3756181 tatttgctca aaaatcgtca atgaatatga tgttgattat caaacctgct tagaagattg 3756241 tatggagctg tttgagttgc ttattgatca tgaagcaatc aaagttaagc agggggcatg 3756301 agaattggaa aaacaaaaag tgcttgcttt accagacgat gtacatgagc tgagtacaca 3756361 ccgttctaaa tcaatcgtaa attacatcat cactctgctt gcctttgcca aaaaacaagg 3756421 attgactcat caagatattg taagctggat tcacgagcaa tatgaggaaa gaggatatta 3756481 tgatgagtgg agacacatta acagccaaca accagttgga tcatttgtgg aactctttat 3756541 aaaaggaaga cgtttacttt atgacaaaat tgaattgttt gaaacagaag ataaatatgt 3756601 cgtaaatacc cacacttggt atgaaaaaga acctagtgag gccttttttt attttgaaat 3756661 tgatcccgaa gaattttctg cgtacgcttc cattctcgca atcgaaaacg caaaacgtct 3756721 cggaattaaa atcgatattg taaaagaaac agatgtagag acagcttata tctataaaca 3756781 tcaataacgc tattgggagg gagacatatg tgcgggctcg cgggtattat aaatctggct 3756841 gctccccgtt ctcaggaatg tacctttcat atattgaaag gcatggcaga tgccatcagc 3756901 tataggggac cggatgatga acaatatcat attgattcca aagtcggctt tgcatttcgg 3756961 cgattgtcca ttcttgacct tgtaaatgga cagcagccct ttttaaatga ggatggatca 3757021 atcgtcgtta tggtaaatgg agaaatttat aactataaag aactgaaggc ttctttacac 3757081 aatcatatgt ttaaaacgac atctgattgt gaagtaattg ttcatttata tgaagaaaaa 3757141 gggattggat ttgtagacga catcatcgga atgttttcaa tagccatttg ggacaaaaat 3757201 aaaaacaaag tatttttagt tcgtgaccgc tttgggatta aaccgctttt ttacacagag 3757261 ctaaaacacg agcttatatt tgcctctgaa ataaaatccc tattttctca tcctcactgt 3757321 ccccgccaat ttaattggaa agaagcactc tcagacattt ggctaagcgg ggaagcagcc 3757381 agtaatcata aagaaaccac ttcctttttt gtaaacatcc aaaatctcga tgctggccat 3757441 tatctcgaaa ttaatttgac aacaaatgaa cgaaaaacag caagctattg gtctttacag 3757501 gatattttgc tcaggcaagg ctatcgtgag aatctccatc ccgatgacct gattgaagga 3757561 tatagagaac tgctggcaga ttcagtccat agatgtttac aaagcgacgt tgaagtcggg 3757621 ttgtttctta gcggtggcat tgattcagct gcagtcgcac attttgctgc agaaaaacag 3757681 gatctccata cgtttacagt attaagccaa agtacattta caaatgaaga tgcaaaatat 3757741 gcccattggc tggctaaaga tttacacctt ccaaatcatc aggttctcta tcaattaggg 3757801 aacgatgagt tattacaacc agagtcatat aaacatttgt tatggatctg tgaaacaccg 3757861 ttttgcggac cggaacaatt atataagttt catttacata agtatgccaa agcgataagg 3757921 ccaaacctga aagtcatgct gaccggccag ggcagcgacg aatttaacgg cggttacagc 3757981 acgacacttt caccagccga gaacccaagt tgggaaggat ttattgaatc ggtcaatacg 3758041 atggagatga accggctgca tcggctgcag ggaaatatct ttagagtgtg ggaggagcat 3758101 tttggacttt ctcctataaa cctttcttat ttaaagagca atgattccag ccaagcagat 3758161 ccttggcaat cgtatgtcct gacaaaatac cgtgatctgc aaatgtataa ttgctggcat 3758221 gaagatcgga tcgccgcggc taatcatatc gaaaaccgtg taccgttctt ggaccatcgg 3758281 cttgttgaat gggtttgcgg aatacctgat ggactccgta aagacttgtt atgggataag 3758341 tcggtattgc gaaaatcatt aacaaatgag ctgcatacaa gctataccca ccggccaaag 3758401 gttccttttt tctatggtaa ggacgtgaga tatacacata aaatgatgtt tcatcttctg 3758461 aagaaaaaca attatcagct tatagaggag gccttctctc acagcgatgc ctccagcata 3758521 atacaggttg aacacattca tgccatcatg acatatttgg aggatgatcc tgagtttaca 3758581 aattttgaat ttttattaag actggtgaac atgggacttt tatcaaaaat gactaaagaa 3758641 accccttctg ttcaattaga cataaccagc catttagaat cgataacaat aaaagactgg 3758701 cactcacagg aaggtgatat tgccagtcgt ttaaatatct cagccaataa gtgtgaagga 3758761 caagatattt tggcgctaaa ccctggcgtc actctgttaa ggccggaaag cgatagtgag 3758821 cattgcatct acattgcgga agaaggattt attcagttta ttgtttcgga ggaagacgtc 3758881 ggagcttggc tgcatattct ctgcgatatt aatggaaaag acacacttca tacgatttta 3758941 gacagacatg gtgtcagcct tgaagaagtg gccaaatata ttcaagaagc catcgaacac 3759001 aatatcattt tgatcaaaca aaaaaatctg ccagaaggag catatagatg agcatctttt 3759061 attcgttttc cgcacttagg ggattagcaa tggggatttt ttcgcctatt tggattcttt 3759121 atctgatatc taaagattat gatttccttc agattggatt aatgggagcg gtacttgaaa 3759181 ttgctaagct tatatttgaa gttccttccg gcgtttttgc tgatcgttat ggaattaaaa 3759241 tttcaattgc cagttcattc tttttctcca tccttacatg ggccttcttc ccttttatcg 3759301 attcagctgc tatttgcata ctggctatga tcatatgggc tttatcagat tccttaattt 3759361 ccggttcttt tgaaacttgg atgagccgtg tcgcagggga agatcgattc ggcaaagaaa 3759421 tgatgaaaaa cacacaattg ctaatcactt ttttaattat tggaagtatt gccagcgggt 3759481 atttgtattc attaaatatc tattttcctt tcctgctcgt tatggtgatc tacttattac 3759541 tatttatttg gatgtctgta tttattaaag tcccttctgt ttccgaaaca aatcatgggg 3759601 atcagaacca acatgattcg ataaagatta tcaaagaaag tttaaaaatt atctttaaca 3759661 aaaaaagggt tcttttaatc gtcatagccg gtttctttac agccacagcc tatgacacaa 3759721 tttcccgtta ctggcagcct tttttgagtg atttaggctt ttcagaaaag tcactgggat 3759781 atatttttgc cctaggaggg tttaccgctc tcgttctttt gacattaacc atcaggttcg 3759841 aaaagaagat cgaaaaaaat ccatatctcg ctttaacctc attggattcc atgggcatgg 3759901 tcatgacttt tctattgtct agagcattca ggccgctggg cattccatgt acagcgtttt 3759961 tgcttgcaat tgaagatatt catcatccga tcgtaacaag ttacttaaat aagtttttcc 3760021 ccgattcata caagaacaca cttttctcgt taaactcagg ggtaggagca attggagaaa 3760081 ttctttccgg tgtcattttc ggcatcattt ccgcagcctt tgggctctct gccatgtttg 3760141 ttgttgtagc tgtatttcta ttaatcccta ttatccttta tacgatagtg cctaagatta 3760201 aagacaatga tatgaaagtt cagattgaaa aatcccagca agtgtaaatg ttttgtatca 3760261 cagtaagaag accttcttat taaaagaagg tcttctgcta ttctattcag ttatttccca 3760321 aaagccatca gcttcgtata acttccaata taaagtgttc cgtcctcagc gagctgagga 3760381 gaagacacga cgttgctgtc ggtttgatag ctccataatt cattgccgtt tgcgtctgcc 3760441 gcataaacct tcatatcatc tgacccgaaa taaaccgttc ccttcgcgtc aatcagcggc 3760501 gccgttctga cagggccgtc tgtgtagaat gaccagttca tatccccgtt tttgctgatg 3760561 gaaaacagct cgccgcttcc tgagccgatg tagatattgc cattatgatc aatcgcagga 3760621 gatgagctgg agaacccgtt tagcgggaat gtccatttca aactgcctgt tgatgtataa 3760681 gcatacagct gtccatcttg gttgccggca taaatgtttc cgtccttatc aatcaccgga 3760741 tatcctttaa acgcatttga cgtcgttctg gaccatttca cctgtccggt tccggagttg 3760801 atcgcataaa acacgtaatt atatgtgccg acatacacgg tgccgttttt ggcaagcacc 3760861 ggcacagagc tgacgacccc atttgttttc aacttccagc gctctgtcca ggttgatttt 3760921 gacgtcggtt tgatcgcgtg aacataatta tcaagtgttg agaaatacaa cgtcccgtct 3760981 gaaccgatca ccgtttcaga gcttggcccg ccgcttaacg gaaccgttgt taaaatttct 3761041 cccgtttctt tgtcaataaa ataaatcttt ttgtcatagg atgccaaata gataacgccg 3761101 ttggtcccaa gtacaggaga ttgcgtatat gtttttccaa gattgcccgt cacccatttg 3761161 actgagccgt ctggattaaa ggctttcatt tccccgtctc tggaatgaag atatactgtg 3761221 ccgtctccgt caatcacagc ccccgctcca ttttgcggag tcgttctgat gtcgttttgc 3761281 catttcagcg tcccgtctgt atttccggcg aaccggcttt cgcgtgacca gttaaacatg 3761341 gcaggcgcca tcgcttgtac atcatatctt cctggcaaaa agccagatgc tccattattt 3761401 tgagaaaaca ccgtttccgc cgcataagca gctgtcggct gaagcacttt ggcagcgggc 3761461 acatcagaaa cagcgccggc cgaaacagcc gccgccaccg cagctcccgc aatcaaagct 3761521 ttcatacgaa atgacttgac catcattgag acccccatta tatgtaactt ctaatttgtg 3761581 accatcataa catattcatc cattttataa atctatttca caaaaacatc acaaactaga 3761641 aaactatgta agagtattca cggacgtttt ttcagcaccc gatcgaaatg cagccacaaa 3761701 ccaaatgacg ttgacagcag ccgcagcgag actaactccc aaaacaaaga tcacctcaga 3761761 aagcagatgg tcactaaaga aactaaacat caagataaaa ccggccgaag acaaatgaat 3761821 caaaagcccg aagccgcaaa gcaccgccat gacatacctc attgcatcga ctccgagcat 3761881 ataaacgaga aatggaatga aatacaagac aaggatcata ccgacagctg accacatgcc 3761941 agctgaatta aactgattgg ccgccgctcc cgttccggcc agcggcgaaa gtgaagccgc 3762001 cacaatcacg gcgcaaaaaa gaaacgcaga aatggttgtc atgatcgcca cgctattttt 3762061 ttttgacatc aaactcctcc tttaatagaa atattaacct tttttattat aagtaagttg 3762121 aatgttatat tcattatatt tttaaaaaat tccagaatac atacacaaat gctatgcttc 3762181 tttctagtat atttatatag taaaaaacaa aggataaaag actcattttt ctgtaatatc 3762241 aggattttat caccatacca tattgcatgt acatgttttt caaagtatac tattccagat 3762301 taattcagag gagagagaaa aatacatgga aaaaccagca ggattttgga ttcgtttttt 3762361 agcttatttt attgacggca ttattgtatc tgttcctagt tatattattc tatttattat 3762421 caattctgtg tttgtagctg gggctgtggc aacaaaccct tacatgacgg aagaagagta 3762481 tttagtgaaa tacatgacgc ttgcattttt gcctactatg ctgatcatga tcgtcatcag 3762541 cgtgttatat tacgggctgc tcacagcttc taaaatgcaa ggcacacttg gcaaaaaaat 3762601 tcttggcctg aaagtggtca atgaacaagg tgaacgggtt tctgtcggac agggaattgg 3762661 ccgttacttt gcctatatct tatctggaat catcttttat atcgggttta tcatgatcgc 3762721 ctttggagag aaaaaaggcc tgcatgacat catttgcaaa acacgtgtcg tgtataaata 3762781 atagaaaaaa gtctagacgc caataggcat ctagactttt gttttctttg caataggctg 3762841 ccacgacaga tacgtagcgc ttctccacaa ccactcaaac ggccccatcc gaaagacacg 3762901 aagccaaagg tggctgaaga ccatttgaac ggcacaaaca gcaattgtaa tgagcacacc 3762961 ggcagcaggg tacacttttc catacaggcc caagccgtaa tgataaaaaa tccaagtaca 3763021 cacaatagac tgcatcaaat aattggtaaa tgccatcctc ccaacagcgg agaatgattg 3763081 cagcactgtt ctcactcttg ttttatgata aagatagaca accgttgtaa catagaaaaa 3763141 catgaggaaa ggcgcgccaa tcagcaaaca tatttcttta tccgttacac tgtacagcac 3763201 ctgggcgccg atgccgatga caagcccagc catccataat cgttttaatc ctttgcgatg 3763261 cttttccggt tcatgcaaat accgtgattt tgctgccgca gctcccagca aaaacatgct 3763321 gaaatatgga atggatgcaa agaagtagtt gagcggatta tacgtaagca tgccattcga 3763381 agacatgtaa acaagacggt cgtggatccg ctgttctgca atatccttca ggctgccgct 3763441 tccataaaca tgaatcgctt gttttgcctg ctgtgttacc gcttgtaccc attcctgtcc 3763501 gtttgattga tcaaaacttg tcaacatgaa cggaatggaa aacagaagat acaaagagac 3763561 cgcccatatc agcagtgttt tcggctttgc ttttcgaaac aagagcagga caaatccgag 3763621 cagggcatat tctgttaaaa tatccccgtc ccatatcaaa aaggcatgaa tcgttccaaa 3763681 caagagaagc gccattaacc ttctcacata taacggaaca aaccgtttcc ctttgttttc 3763741 tgctctctcc atcatgacaa ccatgccaaa tccaaataaa aaggaaaaca ataaaataca 3763801 ttttgtttga atgaagaatt tcagtatgtc tgcggcggca aaatcagctt cagaccactt 3763861 atccatgaaa aaattctctt ttccaagcat agacaaatac atatccggat aactgaaatg 3763921 tgccagattg acaaataaga tgccgaaaat cgccattcct ctcagcacat caagcacacc 3763981 gatccgctca tttgttaaag tcggctgtaa tgaagacata gccatcacgc tccttttttc 3764041 tgtaccttaa gggtaggaaa aaatgaagcg cggtaacatc gatttaggtg tcaggccggc 3764101 atgaaaacct tacaatcttg tcatctttat ggtttcatca cctttaaatc taatgcttcg 3764161 atattctgca aaatgcgatc aaagcgcaaa gcctgaggct cacatgggaa gatgtggcct 3764221 tcatacgggt cgcctaacgt ccggaaaaac ggttcaaata aaccaggaac caatacgccc 3764281 accatctttg tatagtgaga atcaaggcga taggagtgaa cggtatttgc agggacatgc 3764341 aggaaatctc ccggattcag ctgaatttcc tggccatctg tccacatcgt catctggcct 3764401 tcaaggcaat aaaatgtttc tgtatgatat tcatggtagt gatcaacgat tcggtcacct 3764461 ttagggcctt cagatgatac gacgataaac tggccatctg tatttttttg tgcagccaca 3764521 atgcggtgaa gctgatctcc agtcaacaga cgatctcctt ctccagattc aagaacgtat 3764581 ggaaccgctc catctggcag ctctgtaagt tccgctaatt tggccgaaca tgcaggcttt 3764641 gcttcatcta gaaatacaat gtccgctaca gcggctgctt ctgcaaatcg ctcgtttgag 3764701 acttcttcgc ttgcgtacgg cggatgttca gcgtgatcat acggattccc aataacggaa 3764761 tacaagtgcg ctacgtttcc tttcatcgtg taagacacca gtcttgttct gtggctctgc 3764821 atccggtagc tgtgcggtgt tcccgccgga atgttggcat aatcacctga tattaataaa 3764881 tagcgttcac catcaagtgt cagttccagt ttcccgtcca aaacgagaat tccttcatgt 3764941 gtgtccttgt ggacgtgaag cggaaaggca tctccttttc ccccggaaag aagcacgatc 3765001 tcaaacaaat cacctgtgct cctcccattc gccatcaccg tggcaacctg tctgccgaac 3765061 agatagcgct cgccttctcc gctccggagc aaataaggca ttttttcttt aggcaatgaa 3765121 tgtgtacata atgttttcat attatcgctt cctccaattt agaccagtct atatattatc 3765181 attcatttgt ctagaccgtt ctatataatt gtaggagaaa ggataacaaa atgctaccct 3765241 ttttttctca ccagcactgg tatttgttcg gcaatgagaa gaagaggcgt tttgtcttta 3765301 ttcgttaacg aaagcatgat gccgccctca atcatcgaat taatcagcgt tccaagctga 3765361 tttgcttctt cttctgcaaa tccgttttcc attaattttc tggcaaaaac cgcttcccag 3765421 cttttaaaca ccttcatgca aaccgtccgc agcggttcac tgattaacgc tgtctcactc 3765481 gccagcaaac cgactggaat acctttaatg ctttctgtgt tgtcaaattg gctggctgtt 3765541 tttttgataa aaagctgaat cgcttcaaca ggatcagagg attcatccat gctttgctgt 3765601 atcagatgtt caacgatctt acctgtatat gtaaccgctt caattgctag ttcttctttg 3765661 ccattcggaa aaaagtgata aagcgatcct tttggagcac cgctttcttt tacaatctgg 3765721 ttcaaacctg tcgcgtgata tccttgcagc tggaacagac gtgacgccgt gtgaaggatt 3765781 ttttcacgtg aatctcctct gctagtcatt aaaacattcc ctcctaggta tggtagagcg 3765841 acttatataa tataaaaaag aaccctgtga ttgtcaaaag gggtaagacc cttccggatg 3765901 gggtaatgta caaaaacagc gtctaggagg gatctctcaa tgacaatcga tcattcagtc 3765961 acaaatacag agcagcttga acaacagaac cccgccataa aaacaaagct caaactgaaa 3766021 aagcttaagg atcaggtgat cgtcattacc ggcgcttcaa gcggtatcgg acttgtcacg 3766081 gcgagaatgg cagctgaaaa aggcgcaaag gtcgtggcag cagcgcgaaa tgaagaggcg 3766141 ctgaaggagc tcactgatga acttaaggaa aaagggcacg acgccatatg ggtaaaggcg 3766201 gatgtcggaa aagaagagga cgtcaaccgc atcgcagaaa ccgcgatcag cacattcggc 3766261 cgctttgata catgggtcaa caatgcggcc gtctcgactt tcggacacgc catggacgtc 3766321 accgtcgaag acatgaagcg catgttcgac acaaatttct ggggacctgt ttacggaaca 3766381 agagcggctg tcaaacacta caccggcaga ggtgtgccgg gcgcactcat taatgtagga 3766441 agcctgttcg gagacagggg aacggtcatt caatccacat atgcatctgc caaatttgcg 3766501 cttcacggct ggacggaaag catccgaatg gagcttgaaa aggaacaggc gcccgtctcg 3766561 gtaacgctca tccacccggg cagaattgac acaccatata acgagcatgc gcacagctac 3766621 ctcgacaaac agccggctca ttaccgctcc atgatctatc cgccggaagc ggtcgccgaa 3766681 gcgatcctgt ttgccgccga acaccctaag cgcgacatgt acatcggctc acaggccaaa 3766741 gccatcgcca tgctgggcgc gctttttcct cgtctgaccg acagactgat ggaaaaaatc 3766801 atgtatcaca gccagcatgc cgaaagaccg tccaatccga gagaagaaag cgctctttat 3766861 gatgctggct gcggtatgca tgacagaggc acaaataaag gatggatgag gtcaagaagc 3766921 tactacacaa aagcgacgaa gcgcccaatt gtatcggcgg ctgttgttgc cggactagtg 3766981 gcttgggctg ccgccaaacg atgcagataa tctctgacca taagaaaaac ccatgctgtt 3767041 ccagcgaacc atgggttttt cagctgttaa tcgataaaag ccttgttcat acgctgcagc 3767101 agctcgccga acatctcttt ttcctgtgtt gaccattctt tcagcatctg ttcataacgt 3767161 tcaaggcgct tttgctgatc ggcttttaat agttgtttgc cgagttttgt aatggtaaac 3767221 aggctgactc tcccatcaga cgggtctgag aaacgataga tgagctcctt tgcctctaat 3767281 gcagctgctt gtcttgaaag agtagaaata tcaagcttaa acgattcagc caattcctta 3767341 acacgagcag gcccaaactc atccaattgt ctcagtaata agtacgaaga tctctccaaa 3767401 ttccctgttc ttttctccga ttgatccaga taaacagctc tcctgataaa agtcgtcagc 3767461 tcatattcaa ttaattcaac tggattttga ttttgcaatc gctctcgctc cctattccaa 3767521 tctccggcat tgacaacatc atatatactt gtataataca aatgtacatt aactgaataa 3767581 atacaagtcg ttatatgact aaatcaatta ttatacttgt atagtacaat catataaaaa 3767641 gaaagtaaag cgattcctca gaaccatcct agaagcaagc accagaaagg aggaagctgt 3767701 tctgattgga gagcagcact tgatgtgaaa gtcatacgaa ttattttgca agtgttgata 3767761 ttatatgtat tttttatgat cggggaagcc attcagcatc tgtttcattt acccgtgtca 3767821 ggaagcatcg ttggattggt attgcttctg atctgcttgg gcctccgtat tgttcccgtc 3767881 tccatcattg aagacggagc agggttttta ttatccttcc ttccattgtt gttcatcccg 3767941 gcaatgacag gagtgataaa ctatccgtct ctcatttcat tcaatggcct gatgctgctg 3768001 attacagtcg ttctcagcac catcgtcacg atcattgcgg ctggattcgc cagccagcta 3768061 ttagagaaaa aagcaaaaaa acgggaggag aaagagaaat gcagcaagca tgtatcgcga 3768121 tcattataat tcttttaaca gttgccgctt atttagcgat ggtcaaactc tataagcgat 3768181 tcccgcttcc atttctgatc cctgttctga caacgacaat tttgattgta gcggctttga 3768241 tgatgtttca tgtttcctat gaaggctata tgatcggggg gaaatggatc aattctttgc 3768301 ttgggccggc tgttgtggcg ctggcctatc cgctttataa gcaatggcat atcattgtca 3768361 aacattgtgt tcccatttta ggcggcgtcc tggtcggctt atgcatggga atgatcagcg 3768421 ggctgatctt cgcagaagca ttcgggattg atcatgatct cttattatcc attctgccaa 3768481 aatcgatcac aacccctgtc gctattcaga tcgccgccgg tcttggcggc gtcccttcca 3768541 tgacagtcgt atttgtcatg attgcgggct tttcaggcgt catcctcggg ccgcttttcc 3768601 taaaatggct tcgcatacgc agctccctag gacaaggcat tgcattaggc agcgcctccc 3768661 atgcactggg tacctccaaa gcgttggaat atggggaatt ggccgtatcc atgagttccg 3768721 tctccatgac gctttgtgcg gtgctcggct cattcttcgg cccgctcgtc gtctggctgt 3768781 ttcatattta acaaagaaag actgccccgg gggagggcag tctttttcgt ttaagaagca 3768841 aaaaaatcaa tcaacggctg aaagtcctta gataaatcaa cgtcattcgg ttctgcttga 3768901 agcaggcggt caatcatacg ctccagctcc tcaacatcat tcttatccgt atattcaatg 3768961 aagtttaagc tttcaagcca atcccgatat gaatgtttgg ctttgccata gctgtttcca 3769021 aagacaaggc aaggtgtttt ggtgataatc gagaaaatca tcgcgtgaag gcggtcggta 3769081 atcaccaatt tactggagcc gatgcggtcc agcatctcca taaaatgctt ttcacgatca 3769141 gcgtaatcga tggtgtctac cgtatccagc accgtatcgg tacgctctgt gtaagttgtt 3769201 ttttctgccc attgcttcat ctgtgaaata aaatcttcgt cagtcacttt ctccttatcc 3769261 gctcttaaaa taaagagaac gccgtcccgc tcgagctctc gcggcacaat atccaaggaa 3769321 agcaccatgt ccggtgtaaa gatcacattg gagttgaagg tctctttcac aacatccagt 3769381 gtttgcgtct cacgcgcagc aatcgttaag tttgtatttt gatggtacgc atcctgtgtt 3769441 tttttctttt ccttctgtcc ttcctctgta tcctcaaaat aaacggattg tggcagagaa 3769501 attgatttgt agtctttaaa cgccgaaaag acctttcttc tgtcttcctc aatatcgaga 3769561 taaaggtttc ctaaattccc tccgcctgta aagcagacaa tatcgtcttc acgaatgatc 3769621 tccttcacca gttcaatgcc ctcatccgtc gcataatcca taatctcaat gtattcataa 3769681 tacggaaaat gatttttgat aaatttctct tccgcatacg caatcgcttg gtcgccaatg 3769741 tttgtgtagc taggggaacc aaacaaaaat acttttcgtt tatcatttaa cagagcttcc 3769801 ggctccacat ttggcgcaat gccttttact agttttttgc ctttgatttc ttgtacagtc 3769861 atatctgcgt cctccttctg ggatgaattc ctcattgtgt gttaactgtc tctacccaaa 3769921 aagaaggatg gctatgcatt ggcatgtgca tcggctatat cagaaacatc gttttcgcca 3769981 atttgataga cgctgcaatg tcccgcgccg ttctttccat atattccgcg gcatgttcaa 3770041 acgcgtcttc tagtggcacg gctccgggga cgatgctgaa aagcgcatcg attccgtgtt 3770101 gatagacggc attactgtct cgggaaattg atcccgcaat gccgataacg ggcacatcgt 3770161 atgatttagc ggccttggcc accccgatcg gtgtttttcc atgaaccgtt tggctgtcga 3770221 ttcgtccctc gccggtaatc acaaggtctg catcctgaac gatactttca aaatcaaccg 3770281 cttcaaggac aatatcaatg cctcttttca ggtcagcctg aagataagtt agcaggctcc 3770341 atccaagacc gcccgctgca ccggcgccct ctgtatctcg gaaggttgat ccgagcgctt 3770401 tttctgccat atcagcgaaa tggcttacgt tctggtctag tacatccaac atgtcggccg 3770461 tcgcgccttt ttgcggcccg aaaacagccg tagcaccctt tggtcctgtt aacggattgt 3770521 ccacgtcaca ggcaacttcc agtttgacat tccgcaatct ggaatcaagc ccgctcacat 3770581 ctattgatgc aagctgagat aacgcgccgc cccctgggcc aatctcgctg cctgagttat 3770641 caagaagcct tccgcccaat gcctgaatca tcccggctcc cccgtcgttc gtggcgcttc 3770701 cgccgattcc gatgatcaat cgctccgctc ccgcatcaag agctgctccg attaattctc 3770761 ccgttcccct tgttgtagtg atgagcggat ttcgcttatc tacaggcacc agatgcagcc 3770821 ctgaagcagc agccatttca atcacagctg ttctcccatc tcccatcatg ccaaagaaag 3770881 ctctcaccgg ttcccccagc ggccctgtga caacttgctc tatgatcctt ccattggtcg 3770941 catcgaccag agattgaacg gttccctcgc cgccatccgc caccggcaat tttctgtaat 3771001 cagcacccgg aaagaccgat ttgaaacctc tttctatcgc ttcggctgcc tccagagctg 3771061 ataagctttc cttaaaagaa tcaggtgcaa tgatgatttt catccaaatc gcctctttca 3771121 aaacatgatt cacttaacct attgatctcc aatgtaccat aattgatctg gaaatacata 3771181 ccatgcaata tggtaaaaat ttaaataaaa attagaaatg aaagtgtttg cataaaagaa 3771241 atattcacgt tatcatactt gtatacaagt atactccttg agtgaggaag gtgagtgtat 3771301 gctagactcc aaagacctgt tgtatcccgc aaaatggctc tcaaaagcgt caaccggagt 3771361 tcgtgtcgca tacgagctga gaatgcggat cgtttcaggt ctgattgaaa gcggtaccat 3771421 tttatcagaa aatacaatcg ccgccgagtt ttcagtaagc cgttcgccgg ttcgcgaagc 3771481 gctaaaaata ctcgcatccg aaaaaatcat ccgcttagaa cgaatgggag cggtcgtaat 3771541 tggtttaact gagaagaaaa tcgcggaaat ttatgatgtg cggttactat tagaaacatt 3771601 tgtctttgaa cggcttgtca aaatagacat tgagccttta gttaaggatc tcagcaaaat 3771661 tcttgaaatg atgaaagtct caatcaaata tgaggatgct gacgaatttt catttcaaga 3771721 tgtgctgttc catgaaacga ttatccgagc gattgatcat tcatacattc agatgatctg 3771781 gaacaatcta aaacccgtca tggaaagctt tattctttta tcgatgcggg tacggttaaa 3771841 ggaaaagtat gaagacttca caaggatttt agataaccac gagctttata ttcaagccat 3771901 caaaacaaag gatagggcgc tgatgattca gtctcttcac caaaactttg atgatgtgca 3771961 ggataaggta gaagacctat ggctctcaca acaaatgctg gcaaaaggag ctgaatacaa 3772021 caatgactag ttatatgtta ggaatcgata tcggcacgac aagcacaaaa gctgtgctgt 3772081 tcagtgaaaa cggagatgtg gtacagaaag aaagcatcgg ctacccgctc tatacaccgg 3772141 acatctcaac agctgaacaa aatccggaag agatttttca ggcagtcatc catacaacag 3772201 cgagaattac aaaacagcat cccgaaaaac ggatctcttt catttcgttc agcagcgcca 3772261 tgcacagcgt cattgcaatc gacgaaaatg acaagccgct gacgccatgc attacatggg 3772321 ccgacaacag aagtgaaggc tgggcgcata agatcaaaga ggaattgaac ggacatgagg 3772381 tgtacaaacg gacgggaaca ccgattcatc cgatggcacc gttaagtaaa attgcctgga 3772441 tcacgaatga aagaaaagaa atcgcttcca aggcaaaaaa atatatcggc atcaaagaat 3772501 acatttttaa acagctgttc aatgagtatg tcatcgatta ctcattggca tcagcgacag 3772561 gcatgatgaa cctgaagggc ttggattggg acgaagaggc actgcgcatc gcaggcatca 3772621 cgccggatca cttatccaaa ctcgtgccga caaccgagat ctttcagcac tgcagcccgg 3772681 aaatagcgat ccaaatggga atcgatccgg aaacgccttt tgtcatcggc gccagcgacg 3772741 gcgtgctgtc caacctcggc gtcaacgcca ttaaaaaggg tgaaatcgcc gtcaccatcg 3772801 gtacaagcgg tgccattcgg acgattattg acaagccgca aaccgatgaa aaagggagaa 3772861 ttttttgcta tgccttgacg gacaagcatt gggttattgg gggacctgtg aacaatgggg 3772921 gcatcgtcct tcgctggatc agagacgagt ttgcctcctc cgaaatcgaa acagcgacac 3772981 ggctgggcat tgatccatat gacgtgctga cgaaaattgc ccaacgcgtc agacccggtt 3773041 ctgacggtct gctgttccac ccatatctcg ccggagaacg cgctccgttg tggaatccgg 3773101 atgtacgcgg ctcatttttc ggcttgacca tgtcgcataa gaaagagcat atgatacgcg 3773161 cggcattgga aggcgtcatt tacaacctgt acacggtgtt cttggcgtta actgaatgca 3773221 tggatggccc ggtaacccgc atccaagcga cagggggttt tgcaaggtcg gaggtttggc 3773281 gccaaatgat gtcggatatc ttcgaatcag aggttgtcgt tccggaaagc tacgaaagct 3773341 catgtctcgg cgcctgcatt ttaggcctgt atgcaacagg aaaaatcgat tctttcgacg 3773401 ccgtgtccga tatgatcggc agcacataca gacatacgcc gatcgaagac tcagccaagg 3773461 aatacagaac attaatgccg attttcatca atctatcaag attattagaa aatcaatata 3773521 cacaaattgc agattatcag aggggcttaa tcacacacaa atagtacatg acatgaaggg 3773581 gagggcatta ccatgccgtt aatcatcgtt gcacttggga tcttagcatt actatttctg 3773641 attatgggct taaaattaaa cacatttatt tccctgctgg tcgtatcgtt cggcgtggca 3773701 ctggcactcg ggatgccgtt cgataaagtt gtcagctcca tcgaagcagg aatagggggg 3773761 actcttggcc acatcgcgct catcttcgga ctcggtgcga tgctgggcaa actgatcgcg 3773821 gattcaggag gcgcacagcg cattgcgatg acgctcgtca acaaattcgg tgagaaaaat 3773881 attcaatggg ccgttgtcat tgcctcattc attattggga ttgcgttatt ttttgaagta 3773941 ggactggttc tattaattcc gattgtcttt gcgatttcaa gagaattgaa gatttctatt 3774001 ttatttctcg gaatcccgat ggtcgcggca ctatccgtca cacacggttt cctgccgccg 3774061 cacccgggac ctacggcgat cgccggtgag tatggcgcaa acattggaga agtgctgctg 3774121 tacggcttta tcgttgctgt tccgacagtg ctcattgcag ggccgttatt tacaaagttc 3774181 gcgaaaaaaa tcgttcctgc atcatttgcg aaaaacggca atattgcatc actcggcaca 3774241 caaaaaacat ttaaccttga agaaacaccc ggctttggaa tcagtgtctt tactgcaatg 3774301 ctcccgatta tcatcatgtc ggtcgcgacc attatcgacc tgcttcaaga aacaatcggg 3774361 tttgcagata acggagtttt agcttttatc agattgattg gaaacgcatc gactgctatg 3774421 attatttcgt tattggtcgc agtctataca atgggcatca agcgcaacat tccagtcaaa 3774481 accgtgatgg attcttgttc aactgccatt tcacaaatcg gcatgatgct tttgatcatc 3774541 ggaggaggcg gcgccttcaa acaagtgctg atcaacggcg gtgtcggcga ttacgtagca 3774601 gacttattca aaggaacggc attatcgcca atcattctgg catggctcat cgcagcgatc 3774661 ctgcgcattt ctctaggatc ggcgactgtt gccgcactaa gcacaacagg tctggtcatt 3774721 ccgttattgg gccattctga tgttaacctg gcgttagtcg tactcgcaac aggagccgga 3774781 agtgtcatcg cttcacacgt caatgacgcc ggcttctgga tgttcaagga atacttcgga 3774841 ttaagcatga aagaaacatt cgccacatgg acattgctgg aaaccattat ttccgttgct 3774901 ggactgggat tcattttatt gttaagttta gttgtatgaa attaagaagg agctgtaaca 3774961 catgttcaat tcgattggtg tcataggctt aggcgtaatg ggaagcaaca tcgccttaaa 3775021 catggcaaat aaaggcgaaa acgtcgctgt ctataattac accagagatt taacggacca 3775081 gcttatccaa aagctggatg gacaatctct cagcccgtat tacgagcttg aggactttgt 3775141 tcaatcgtta gaaaaaccaa gaaaaatctt tttgatggtc acagcgggaa aacccgtaga 3775201 ttccgtcatc caatcattaa agcctttgct tgaagaaggc gacgtcatca tggacggagg 3775261 aaactcccac tatgaagaca cagaaagaag atatgacgag ctgaaggaaa aagggatcgg 3775321 ctacctggga gtcggcattt ccggcggtga agtcggtgcg ttaacagggc cttccatcat 3775381 gccgggcgga gatcgcgacg tctatgagaa agccgctcct atcctgacga aaatcgcagc 3775441 ccaagtcgga gatgaccctt gctgtgtcta tatcggacca aaaggggcag ggcactttac 3775501 aaaaatggtg cacaacggca ttgaatatgc cgacatgcag ctgattgcag aagcttatac 3775561 gtttctaaga gaaacgcttc gtctgccgct agatgaaatt gcatctattt ttgaaacatg 3775621 gaatcaaggt gagctgaaaa gctatttaat agagattaca gctgagattt tacgcaaaaa 3775681 agacgaaaaa acaggacagc ctctgatcga tgtcatcctt gataaaaccg gccaaaaagg 3775741 caccggaaaa tggacgagca tgcaggcgat tgataacggc atcccgtcca cgatcatcac 3775801 agagtccttg ttcgcccgct acttgtcatc tttaaaagaa gaacggatgg cagctcaaga 3775861 tgtattagca ggcccggaag ccgaagaaaa acacttggat aaagacactt ggattgaata 3775921 cgtcagacag gctctttaca tggggaaagt atgcgcctat gcacaaggct ttgcccaata 3775981 taagatgtca tctgagcttt acggctggaa tctgccgctc aaagacatcg ccttgatttt 3776041 ccgaggcggc tgcatcatcc gcgctgattt cctaaacgtg atcagcgaag cattcagtga 3776101 gcagccaaat ctggctaacc tgctgatcgc gccttatttc acagataagc tccatgccta 3776161 tcaaacaggc ctgcgaaaag tcgtttgcga gggtatcagc accggaatct ctttcccatg 3776221 cttaactacc gcgctctctt attacgacgg ctaccgcaca gggcgttcca atgcgaacct 3776281 cttgcaggca cagcgcgatt actttggcgc tcacacgtac gaacggactg atatggacgg 3776341 cgtcttccat acgaattggt ctgaataacc tgtattaaaa acacggtcag tttcaactga 3776401 accgtgtttt tttcttctat cccaaacaac agaagacata agttatgttt taaatatcat 3776461 aaacagtgat acaataatag ctagaaacaa tccccaagat catcatgtga cagcagattg 3776521 ctgttccgtt ctattctgct tttggccatt gtcctttgcc cttgaccatg gtgtcataaa 3776581 atgttcaaat gccaaaacgg cctggcattc tgatttacaa aagtccctga aaaccttatc 3776641 taattgagaa tcagcctctc atttattata aaagaaatgc ctaaatccta cctgtcacac 3776701 ctttattaag atgaaaaaaa gtaggttatg gcttgacaaa aaatatatat taattaataa 3776761 ttcatatata attagaatta ttattgaaag cgattatgct ttctaataca tttttaggag 3776821 gaatatacat tatgtcttta atcggtaaag aagtacttcc attcgaagca aaagcattca 3776881 aaaacggtga attcatcgat gtaacaaacg aagatttgaa aggccaatgg agcgtattct 3776941 gcttctaccc agcagatttc tctttcgtat gcccaactga gcttgaagat cttcaagaac 3777001 aatatgctgc acttaaagaa ttaggtgttg aagtatactc tgtttctaca gatactcact 3777061 tcgtacacaa aggctggcat gacagctctg aaaaaatcag caaaatcact tacgcaatga 3777121 tcggtgaccc atctcaaacg atctctcgca acttcgatgt tcttgacgaa gaaactggcc 3777181 ttgctgaccg cggaacattc atcatcgatc cagacggcgt tatccaaact gttgaaatca 3777241 atgcaggcgg tatcggccgt gacgcaagca accttgtaaa caaagtaaaa gcagctcaat 3777301 acgttcgtca aaacccaggt gaagtttgcc cggctaaatg ggaagaaggc ggcgaaactc 3777361 ttacacctag ccttgatcta gtaggtaaaa tctaaggagt gcattcaatt ggtacttgat 3777421 gcaaatatca aagcacaatt aaatcaatat atgcagctaa ttgagaatga cattgttctc 3777481 aaagttagcg caggcgaaga tgacacttct aaggacatgc tggctctcgt tgatgagctg 3777541 gcttccatgt catcgaaaat ttcagttgaa aaagctgaat taaacagaac gccgagcttc 3777601 agtgtcaatc gtgtcggaga agacactggc gtgactttcg ccggtatccc tctgggccac 3777661 gaattcacat cattagtgtt ggcgttgctc caagtgagcg gcagaccgcc taaggtagac 3777721 caaaaagtca ttgatcaggt gaagaagatc agtggtgaat accacttcga atcttatatc 3777781 agcctgacat gccacaactg tcctgatgtt gtacaagctt taaacatgat gagcgtgctg 3777841 aacccgaaca ttacgcacac gatgattgac ggtgcagcat acaaagcaga agttgaaagc 3777901 aaaaacatca tggcagtgcc gaccgtttac ctgaatggcg aatccttcgg aagcggccgt 3777961 atgacgcttg aagaaattct tgcgaaaatg ggcagcggca cagatgcatc tgagtttgct 3778021 gacaaagagc cgtttgacgt tcttgtggtc ggaggcggac ctgctggtgc aagtgcagcg 3778081 atctacactg cacgtaaagg catccgaact ggtgttgtcg ctgagcgctt cggcggacag 3778141 gttctcgaca ccatgagcat cgaaaacttc atcagcgtca aagcgacgga aggaccgaag 3778201 ctagcggcaa gtcttgaaga gcatgtgaag gaatatgata ttgatgtcat gaaccttcag 3778261 cgtgcgaaac gccttgagaa gaaagatctg ttcgaacttg aactcgaaaa cggcgctgtc 3778321 ctgaaaagta aaacagtgat cctttcaaca ggtgcacgct ggcgcaatgt caacgtcccc 3778381 ggtgaacaag agttcaaaaa caaaggtgtc gcatactgcc cgcactgtga tgggccattg 3778441 tttgaaggca aagacgttgc ggtaatcggc ggcggaaact ctggtatcga agcagcgatt 3778501 gatcttgcag gtattgtcaa tcacgttact gtactagaat tcgcgccgga actgaaagca 3778561 gacgaagtcc tgcaaaaacg tctctacagc ctgcctaacg ttactgtcgt gaaaaacgca 3778621 caaacaaaag aaatcacagg tgatcagagt gttaacggca tcacatatgt agaccgcgaa 3778681 acaggcgaag aaaaacacgt tgaacttcaa ggtgtattcg tccaaatcgg tctcgtgcca 3778741 aacacagaat ggttagaagg aacggttgaa cgcaaccgca tgggcgaaat tattgtcgac 3778801 aaacacggcg caacaagcgt accaggctta tttgctgccg gcgactgcac agacagtgcg 3778861 tacaaccaaa ttattatttc tatgggatca ggtgcaactg ccgccctcgg cgcgtttgat 3778921 tacctaatcc gtaactaata taagaaatcc gctatattgc cagattggca ggatagcgga 3778981 tttttctttt tctacagaaa aaaaccgaac caggcactac ggtaaaagtg ctcgattcga 3779041 gcgcttctta tagttcctca ccattcgttt gaatgacatt tttataccac tcaaaggagt 3779101 ctttcttata tcgtttcatg gatccgtttc cttcattgtc acgatcaaca tagatcatgc 3779161 cgtagcgttt tttcatttcg ccagttgtga aggagacaat atcaataatg ccccacggcg 3779221 tgtagccaat taaatcaaca ccatcgtacg tgaccgcttt tttcaatgct tcaatatgcg 3779281 attttaaata ttgaatgcgt tccggatcat gaaccttgcc gtcctcctcc agcgtatcca 3779341 ctgcgccaaa gccattttca acgatgaata acgggatttg gtatcggtca taaaaacgat 3779401 ttaacgtata tctcaacccg gttggatcaa tcgcccatcc ccagtcactc gaagtgatgt 3779461 acggattttc gacaccattc ggcaagccgc catttacaat atcgccagtg ttatcatttt 3779521 tcacatcgct tttcacagtt gttgacatgt aatagctgaa gcctaagtaa tcgacggttc 3779581 cgtttcttaa aatctcatca tcgccgtctt cgaatgtgat gttgtagcct tcgcgttcaa 3779641 attccttcaa cgcgtagctt ggataataac cgcgaacctg cacatcaggg aagaaatagc 3779701 gctgcctcat ttcttcttca gccagcatca catcttcagg attggaggag aaaggataaa 3779761 tcggcacgtg tgataccatg gccccaatct ggaactctgg attgatgtct tttccttttg 3779821 ccactgctaa ggcgctcgcc actaattcat ggtgcgccgt ttgatacatg acttccttgg 3779881 cgttttcgtt ttcgccaacc acaacacctg aattcgtcca taggaacagc ggattgttca 3779941 catccatttg gttgttaatc tcgttaaatg tcatccagta cttcacttta tctttgtaac 3780001 gggtaaagca agcctctgcg aagttgacga agaagtccac gactttccgg tttctgaagc 3780061 cgccatattc tcttgccagg tgcagcggca tttcaaagtg agacagggta atgaccggct 3780121 cgatcccatg cttcagcaat tcatcaaaca catcatcata aaactgcaaa ccagcttcgt 3780181 tcggttcagc ctcatcgcct ttcggaaaaa tccggctcca gccgatggac gtccgcagac 3780241 attttaatcc catttccgca aacaaagcga tatcttcctt gtatctgtga tagaaatcaa 3780301 tggcttcatg gtttggataa aattcgtttt cttcaatcgt gtcagtgatt tttctcggca 3780361 cgccgtgcgc acccgctgtc atcacatcga cgacactcgg ccctttaccg ccttgattcc 3780421 atccgccttc aaattggtgg gcagctaaag caccgcccca taaaaaatcc tttggcatgt 3780481 ttcccatgtt taattcctcc tcagcttacg actgtaaata ttttttgatg taatgcactt 3780541 tcctcaatgt cttcaatgaa agctttatca aactcaacaa gcacttcgcc ttttttgacg 3780601 gtatcgcctt cttttacctt caaggaaaaa ggcgtgccgt caaatgtcac cgtatccagc 3780661 ccgatgtgcg caagcaattc gacgccggac gctgaacgca ggccaatcgc atgctttgta 3780721 ggcgtaacca tgacaaccgt aatgacgccg ggatggtagc atcgatttca cgatatcctt 3780781 cgctttaggg gtagaccgct tcagcaccaa tcgaagtctg gtagcgcagc gagaagcccc 3780841 aatcacattc tcttccccgc ctacggcctc taaaatgtct tttgctagtc tcgtataatc 3780901 tctcactttc cccgacattt cacccacccc ttcgttttgg ttacgctttc attataattg 3780961 taacggtata atttatcaat tccgaaacaa aatatttacg cactaactat cattgtaagc 3781021 ggtttatgct ataattttga caagtgaaac taaacgaata aatgaggaat gcgtatgtta 3781081 aaataccagc aaatcgcaac ggaaattgaa acatatatag aagaacacca gcttcagcag 3781141 ggagacaaac tgccagtcct agaaaccctc atggcccagt ttgaagtcag caaaagcacc 3781201 atcacaaagt ccctcgagct attagagcaa aaaggcgcga tctttcaggt cagaggaagc 3781261 ggcattttcg tcagaaaaca taaacgaaaa ggctatatca gccttctgtc gaatcaggga 3781321 tttaaaaaag atctcgagga tttcaacgtc acctcaaaag tcatcgaact ggacgtgaga 3781381 aagccaacac cggaagcggc ggaaaacctg aacatcggaa tggacgagga catctactat 3781441 gtcaaaaggg tccgctacat caacggccag accctttgct acgaagaatc ctattacacc 3781501 aaatccatcg tgacgtattt aaacaacgaa atcgtctccc actccatctt ccattacatc 3781561 cgggaaggac tggggttgaa gattggtttt tctgatttgt ttctgcacgt gggccagctt 3781621 aatgaggaag aagcggaata tttgggatta gaggctggac tgccgaagct gtatatagaa 3781681 agtatttttc acctgacaaa tgggcagccg tttgattact cgaagatttc gtataattat 3781741 gagcagtcgc agtttgtggt acaggctaat agttttttat tatagggctc ttcactacgg 3781801 taggtggtcg acatgtacaa aattatcatt cctgccatac tagccatctt tgcgctctgg 3781861 atactcttac agatttcact agagatgagc atcgttaaga atccaatgaa ctactttatc 3781921 gtattcatta tctttttcct ctttgtaaag atggtgaaag aaaaacaata atagtttggg 3781981 cgatgcaaac agaaaaacat ccttccctta acaaactcag ccagtcacat gcattaatct 3782041 tgatgttaat gatatatagg tgcacataaa aagctacttc attgtgaagt agctcccttt 3782101 attaaaggcc cattttgatc catctagttt tagaaaagcg aaggacaatc gcatttatga 3782161 taataattga aactaaatac aaaataataa ataaaacatc attactccca agtgtcatgt 3782221 tatcagattg cagcactctt tctattcggg ggtacatagt gttacctgcc tcaaaaggag 3782281 caatgaaacc aaacgtttta ttgcttatag ctactaagat aacagaagtc atccaataaa 3782341 cgatactgac acctatacta attaatatat taggacataa cacgcttata gttccgataa 3782401 ttagaatata ctgcagtata actgcagaaa ataaaaaaag taataatgca aaatgcgaaa 3782461 aatcatggta catcaacgat atgattagca ggcctagcgt tataaatgca aaacattcta 3782521 aaaataaaac agctatcttt ttataaaaga aagtatagat gttctctcca attaacttgt 3782581 aaaagagaat atttttgttt gaatactctc tattaataaa gaaagctata acaaatgaaa 3782641 ataacatcaa accaaactgg gtcgcaacag tataggagct aaagaaaaac atttcaggtg 3782701 taacattact gactttatcg attccaacaa gtaaaaaata acccagcaaa aataaaaata 3782761 caaacattgc tcctaaaata atgataactt tgttgctaat actcttttta aactctaatt 3782821 tcatctcaag cccccactgt tttattactc atttatatac acttcaatta atttatccac 3782881 tgaatgatat tgttgaattt cttggtgatt aaatatataa taatcccctt ctatcgcctt 3782941 taaatcagac aaatcatgtg taatgttgat gataatcttc tcggggttct cctgaatata 3783001 cttgtttaag aagccatgaa tctctataac cgtttttttg tctaatgaat tcgttatttc 3783061 atctaaaaca ataatatttt tatcctctaa taagaaactg agcaatttta atttttgctt 3783121 ttgtccatca ctcaaatttt tgatcagaac ttttccatca atattatcca gattaagtaa 3783181 atatgcgatt ttatctatca tttttgcatc aaatttttta ctcaaaaagt gtaataaaaa 3783241 gtccttagaa acatcattag gtatattcga cgagctggat attaaagaaa cattttgacg 3783301 aatatctctg ccgattcttt tgctattatt caacaaaaag tctttagcaa gctgtgattt 3783361 accgactcca ttttttccga caacgtgatt aattttcccg ctcgaaaaat gcaagtcggt 3783421 gtcctgaagt aacgttttgc ctttcacttt taaagtgtaa ttcgctatat tcatatacat 3783481 actcctagga aatatttgca taataataaa atgttctgcc ttgtgatttg ttactaatgt 3783541 ctaagctttt gaggtacctc tttcgtttcc gatccggaag cgaaagaaat gtttttagat 3783601 ggctaatttg gagatctttt actctagttt acaatatata atatccaatg tacaactgaa 3783661 ttcactgcaa ggccaatccc tataatttga atcgtaagaa ctaaccaatg atttgtctta 3783721 aaacggctat attcatctaa gctcagaaaa gctaaaagaa ttttgtaacc atcagaattc 3783781 aatattggga ttaagttcca caataaagta gacgagaaaa gcataaatgc catagttaat 3783841 gcttcactgg aaaatgtaaa ttgatttatt aattctaatg tatttattaa aagataattg 3783901 ataaacaagc caaataaatg aacgattatc ttttcatttc ttgatagcat gtaggtttca 3783961 ttcaattgga cataaaaagc aggaaataca taaaaattca gtttgaatcc cactttatca 3784021 aagtttttcc cgaaaaattt taaggaataa atatgtccca gttcatgaag cactatattc 3784081 attataaaat aaataactat aattatccac attttccagc cgtaaaatac tgaggacaat 3784141 ccattttgca attttattaa atgaatataa tttaatatga acatgagagc cgtaaaggat 3784201 aagaacagat aaaaaaactt tggtgatact ttctctttat acattttaaa acgtaataat 3784261 tgtttatctg acagagaatt taaactattt ttatagtatt ctccgctttt tttgtctttt 3784321 ataaatacgt tgttttgcac aagcacttca tatttttcat cttcatactt taaaattttc 3784381 attatagtat ttttccatat aaggatagaa gtagtttatt ttttctgcag agttgaataa 3784441 ggaaccacaa actccacaaa tagaggaaaa ttcataagga atgtcaaatt cctctatttt 3784501 gttattttct tttaaaatat tcaaaaacca tttgaatcct tcttttctaa gaataaataa 3784561 tagcaaattg gaatttaact tttccacggt tctttcgaaa ctttggttat attcttccct 3784621 tagggttatt ttcgtttcaa aaatagcagg ggaacaacat ggataaattt ctccatcatg 3784681 atgatataca atgtcatatc cgggacaatg taaggaatct tcatcttcaa gactgtaaaa 3784741 tttatgtatg ttttcttgct taattctagt tttagcagcg ccaactgata tcattggaaa 3784801 ttttgttatc tttacaccta agattgaatc ccccaattcc tctaaaatgt ggttggacat 3784861 tttgtctttg gtaactgcca tattaagaga aatatcgata tcagggtatt tcctgctatg 3784921 ttctaatatg tttttaatac tggaagactt gacaaatgga gcatggtact catcataact 3784981 tatagtcagt gctatcacat ttaaagaatt catatcatga aagtactcct ggaccttttt 3785041 cttgctcaaa ccccaaaatc cattagagat caacgttatt tgtttttcat atggtttaat 3785101 gatttccatt agttctttta aaaatttata atctaaaaaa acttccccac ctgtaaaaga 3785161 aatcacttga atggttttgt tttttgcaaa ttcagttact aactctctta tgtattcttt 3785221 ttccatcctg gttgttgaag ttggtgaact agaaaaacaa caatggtcac aggatgcatt 3785281 acaccttgaa tctaaattga ttgatactgt tttattatac atgaaatatc ccccaacaaa 3785341 tggtaaagga gagttagact ctcctttgta cccctctaat taatgaccac ttccaagaat 3785401 ccagcgattt tcttttgatt ttacaaaata ccaaagatca ttcacttttg ctaacttttg 3785461 tgattcatct aatagaccct taaattctaa gtttttcaca gtctcattgt tagtgatttc 3785521 ctttttcata ttatccctcc tccttttcta atataaacca attattctat atcattcaat 3785581 acatgtcaat atattgtacc taaaaaatct gaaaaatgtc actattcttg gtatataaag 3785641 cctatagtcc tctagcccct ctaagctata ccgaatgaaa ggccatagtt tgatttaaag 3785701 cttcgtaatg aaaagtaaaa catcaatatt gactacacta gttaagggat atacagattt 3785761 taagtggaag aaatgaggca aacaatctta ccctaaacca acctgtactg aaaagctgtt 3785821 ttaagctctt gcttacccca tttggcacct ctttctctcg ttttaattgt ctctaaaagc 3785881 agttatgcgg tactatcata taaaggtcca atgtttaaaa ataatgtcat acttttaaat 3785941 tcaccttatc atgcacatgc tcataaagag gggtttattc taaaaagggg atggacggtt 3786001 ttggaaagca agtacctaga tctactcgca caaaaatacg attgtgaaga aaaagtggta 3786061 acagaaatca tcaatttgaa agcgatattg aacctgccaa aaggcaccga gcattttgtc 3786121 agtgatctgc acggagagta tcaggcattc cagcacgtgt tgcgcaatgg ttcaggacga 3786181 gtcaaagaga agatacgcga catcttcagc ggtgtcattt acgatagaga aattgatgaa 3786241 ttagcagcat tggtctatta tccggaagac aaactgaaat taatcaaaca tgactttgat 3786301 gcgaaagaag cgttaaacga gtggtataaa gaaacgattc atcgaatgat taagctcgtt 3786361 tcatattgct cctctaagta tacccgctcc aaattacgca aagcactgcc tgcccaattt 3786421 gcttatatta cggaggagct gttatacaaa acagaacaag ctggcaacaa ggagcaatat 3786481 tactccgaaa tcattgatca gatcattgaa cttggccaag ccgataagct gatcaccggc 3786541 cttgcttaca gcgttcagcg attggtggtc gaccatctgc atgtggtcgg cgatatttat 3786601 gaccgcggcc cgcagccgga tagaattatg gaagaactga tcaactatca ttctgtcgat 3786661 attcagtggg gaaatcacga tgtcctttgg atcggcgcct attccggttc caaagtgtgc 3786721 ctggccaata ttatccgcat ctgtgcccgc tacgacaacc tggatattat tgaggacgtg 3786781 tacggcatca acctgagacc gctgctgaac ctggccgaaa aatattatga tgataatcca 3786841 gcgttccgtc caaaagcaga cgaaaacagg ccagaggatg agattaagca aatcacaaaa 3786901 atccatcaag cgattgccat gatccaattc aagcttgaga gcccgattat caagagacgg 3786961 ccgaacttta atatggaaga gcggctgtta ttagagaaaa tagactatga caaaaatgaa 3787021 atcacgctga acggaaaaac atatcaactg gaaaacacct gctttgcgac gattaatccg 3787081 gagcagccag atcagctatt agaagaagaa gcagaagtca tagacaagct gctattctct 3787141 gtccagcatt ccgaaaagct gggccgccat atgaatttta tgatgaaaaa aggcagcctt 3787201 tatttaaaat ataacggcaa cctgttgatt cacggctgta ttccagttga tgaaaacggc 3787261 aatatggaaa cgatgatgat tgaggataaa ccgtatgcgg gccgtgagct gctcgatgta 3787321 tttgaacgat tcttgcggga agcctttgcc cacccggaag aaaccgatga cctggcgaca 3787381 gatatggctt ggtatttatg gacaggcgaa tactcctccc tcttcggaaa acgcgccatg 3787441 acgacatttg agcgctattt catcaaagag aaggaaacgc ataaagagaa gaaaaacccg 3787501 tattattatt tacgagaaga cgaggcaacc tgccgaaaca tcctggcaga attcggcctc 3787561 aatccagatc acggccatat catcaacggc catacacctg taaaagaaat cgaaggagaa 3787621 gacccaatca aagcaaacgg aaaaatgatc gtcatcgacg gcggcttctc caaagcctac 3787681 caatccacaa caggcatcgc cggctacacg ctgctataca actcctacgg catgcagctc 3787741 gtcgcccata aacacttcaa ttccaaggca gaagtcctaa gcaccggaac cgacgtctta 3787801 acggtcaaac gattagtgga caaagagctt gagcggaaga aagtgaagga aacgaatgtg 3787861 ggtgaggaat tgttgcagga agttgcgatt ttagagagtt tgcgggagta tcggtatatg 3787921 aagtgagggg tgtggggttc agggatggtg atatgctgct cccctaaaag tagatagatg 3787981 aattttagaa aatctgtttg ccttggggag ttttttcatg gctggacaat tatactacaa 3788041 ggaagaaata ctaatactta tagaatgtaa ttgggtaatg attcggagaa agaggttgcg 3788101 aaataatatg gtattacact gaaacaatta tcaatggaga acatgcacga tatagccgtt 3788161 ctatattctc cctctattat ggcactcatt agtagacata accgtaaaaa aatgcactca 3788221 aaaaaagtcc attctatata actctcgcta gggtggacct ttttcaacat tcaaagtact 3788281 agattttttc tagtgaaaga ataagaaaag acataagttc tattttatca ctctgttata 3788341 ggttaagtta ttacggtgtt tcattatata ctgaatttaa acacccttga cattatggga 3788401 atttttaaaa caggttaaaa ggaagttcta taagaactcc ctagtttaat attatttggt 3788461 caaaatctaa aaccaaaaaa tctattttta tcttcattgt ttctatctaa ttttgcaaca 3788521 atcatacctt tcgactctaa ttcttgaagg tcatctaata ataattcatt tttatttatt 3788581 gttacaaaat attgtccgat cctattctct aacagacttg aattgatatg ttttaataat 3788641 gtacctttta catgaggatc aggattagaa taagatccgt catgaattaa aatattcaaa 3788701 ctacacttat ttatacacct gtataaaaac caagtaagat caaatatatt tatcttcata 3788761 tggagtctac catgtgaacg ttcatccggt atagaacaag aaattttgat ccttcctgta 3788821 gttgattgtt ttgcgttact tattctatta tcatattcaa aatctaaaaa tccatgttgg 3788881 ttgtatgtaa catccattag attattaaaa agcttcttta actcactaac tatagcgcta 3788941 taagattgaa actcatcata atacattgaa ttaactctta atatttcatg ttgaagttca 3789001 ttaatcttat caaaaatatg gtttttttta tcgtagtcac taattctcaa tcttacttcc 3789061 gctaactcta tttctttcct tctttgttct tccatcacaa tggaaatatc ctcaatgaaa 3789121 ttgttactct ttaaaattct ggcacttgat tccagttgtt ctgttaatcc ttgctttttg 3789181 atattaagtt tttttaaatc ggcttgtatt ttaacaattt tatctttaaa ataactccct 3789241 ctactttcta ccatgaaatt atagaactct tggactttat tataattctg ttttacttcc 3789301 tctggaaaaa aacctacaat atcttcatag aatttttcta tattttctaa ttctttaatc 3789361 ttagttactt ttttatttaa atcatctata tttctttgat attgtttaca aatatgttca 3789421 ttttcaaata tttcattttg tattttatta agttcacttt taatttctga gtacctattt 3789481 gtatcattat tatatttatt ggcagtctta gtttgataga taactctatt gtaatcctct 3789541 atctcattta ttaattcatc ttccttaact tttaaatcgc caatgttaat attcattgat 3789601 tcaatcaatt ttatttcact atttaatttt tcaatcttat cccgaaaaac ctttatgttt 3789661 ttttctgtat gagttggtaa agtaaaaaga tagttaagta atttatattg ttttaaccct 3789721 cccctattcg gtaaaactat atcattaaac cctgtctttt cgtctcttat aatatactcc 3789781 cttaacgccg caaaagttat atcctctttc tcacccttta aaatttcctt ttcaataaat 3789841 tttttatata cacttatact aacttttttc cattcctcca aattaaaagt taaagaagta 3789901 tcatgtaatg tataaccatg tttaggagaa ttaaaagatc tagcaaggaa tacttgattt 3789961 ccatcaattt ccacattcaa aacaataaaa acgtttttat tgagaagaat ttcatttgtc 3790021 gtataaaaat ttgatatagt cttccctagt aaaaaggaga tgcattcaat catcgttgac 3790081 ttacctacac cattagtctc ttcatgatct tctctctttt caccaagtat tatatttact 3790141 cctacagcat taaatttata ctctttcaaa atttcttggg aattgcaaac aaaaagattt 3790201 tttataatca taacaatcac taactctccg ttctgctaat catattttga ttaaaagaaa 3790261 ctttacctaa tgaatataaa aaagttaacg ataaatacag tatccgttca atattcaaat 3790321 ttattataat accttgactc ttagcataat caagaaaaag ttgatcaata tgtttttcct 3790381 tctctaacag ttcataaagt atctttgatg agtataaaat attttcttcc acagcattat 3790441 atttagttaa taaaaaatga ttcatttctg gcctctccgc cttttccttt tttaaaggag 3790501 aattattcac tagaggaata agatcatttc caatttgaat gtttttaaac tcattttcta 3790561 ataaaacata agagtatttg agaatatttt cagctgtttc aattttaaga tcaatcattc 3790621 ttaacacttc ttttgttatc attaaaaatc tcacattcat aaatgcacca acatgttaaa 3790681 atcttaatgt attttttcgt taaagccttt gaatatggta aaactgaatg acattctaga 3790741 taaatctcat taacaatttt tacaaatatc tcatctccat tattatattg attatgaaac 3790801 tctagatatt tgtctactat cgtctcagca atcaattcct ttttatcagc acttacatac 3790861 gaagtggaat ccattatatg gtttatcaca ccaaaatact cagaataact atcgaatttc 3790921 cgtttaaaag tttccccact tttcatatca taaaattttt tatctaaacc aatttgatta 3790981 tcaaaattac tagtaaatgt tttataactt tctctatact catgaaaatc tataataaag 3791041 ctcttaaact catcttcatc aattttatca tcgttatctt ctatttcttt ttcaataagg 3791101 ctctctaatc tattaatctt ataatttaac ttcccttcct gtagtctcct tcctccttgg 3791161 ttgttttttg accagtattt atattcggta ttccaaatgt agtatgttac ttctgtctcg 3791221 ccattatcta aattcacatc caccgaaata aattctggag tagcatactc atcctttata 3791281 atggctccac ttactaattc taagaatgga ttttcatttg tatttgcagt aatattaaat 3791341 gaagaatcat gtacatgtcc tgccaaatat agatcaataa agtaatcatc aaaatgtgcc 3791401 tttattgatt ctctttcgga agattcaata caacctaacg tatggtgccc aatagctata 3791461 tttaatacct tgcccttatt tttctctttg ttcatcttcc ttattgcttt atataatttc 3791521 atctgtgcag ttaataacgt tccttcttca ccttttttat ctgataacag acatgtattt 3791581 attgataaaa cattatactt ctccgattga tacaaaaaat gcaaatcttc ttccggatat 3791641 ttaacaccca taaaatcttc ataaaaatcg aaaaatttcc tttgaccttc cactaatata 3791701 tttgtagctt tttgatctag tttatccaac atttctgagg ggttaggaga tttcataata 3791761 ctatcaatca aaagtgtcct cgtcatgtct ctagatatat cgtgatttcc tggcactaag 3791821 tgtacgttat tcttacttaa tcccatactt ttaataattc cattaagata ttctttaaca 3791881 tcttcgttat acacatcacc tttgtgtgct atatctccag ttaataataa aaaatcaaaa 3791941 tctgactctc ttcttaaaac ttctataaaa tctaataatt tatctctcat tacaatagtg 3792001 tcataatttt gaaactgaaa atgcaaatca gaaatttgta aaaaacgtac cttcaataca 3792061 aacatcctct cataagtata tttatcccct atatatttct agaaaacttt ttattctata 3792121 tcatctttac tctttaatat attaagactc tttccacacc atcaaataaa ttataaccta 3792181 aacataactc tttactcatt ttagtattgt atttaagtca aacattgcat tggttgctga 3792241 aatattatat tcattgaatt attccattaa atagctttta gttgaacttt agtctttctg 3792301 taatggtgga gatgctctta cttatgataa ggctccccac gattaatccg aaaagcccga 3792361 taaatctgct ccactaaaat aagccgcatc aactgatgag gaaatgtcat cttcgagaac 3792421 gatagcttct cgtccgctcg cttcatcacc gtgtcactca atccgagtga tccgccgatg 3792481 acgaaggtga ctttgctttt tccataagta gccagcttat ctattgtatc ggctagttct 3792541 tcggatgttt tcatttttcc ttcgatggcg agggcgatga cgtgggcgtc ggggctgatt 3792601 ttggatagga tgcggtcgcc ttctttgtct tttatgattt tcatgtcctg gtcgcttagg 3792661 ttttccggcg ctttttcgtc cgggagttcg atgatgtcga tttttgcgta ggccgaaagt 3792721 cgtttggtgt attcttcaat gccttgcttg aggtattttt cttttagttt tccgattgtc 3792781 acaatattga tattcacagg tcatccccac tttaaaaaca agttattcat atatgttgtc 3792841 cacaattgtg gatatctttt ctgtattttg tgtaagatca ttcgttcccc actatatata 3792901 ctgcggggtc tccacataat tcacaggctg tggataaact gttagtatgt tcgatttttc 3792961 tgatttcggg cggcagctcg tggtcgtcta tgtacatatc cagcaccgtt tcgatgtgtt 3793021 cttcacaaga ataatacgct tgtttcatgt tcaaatcctc cgatgttttc ttccattttt 3793081 acaaatgttc tcttctcaat ataacctatt tattcacatg ttagtagtgc ttcgggctga 3793141 gttttatcca caattcgaca aacaagctgt tgatgactct atttcgctcg tgtgttagtt 3793201 tggatgtaac cgatgtgtgg ggaggtctgc atttgcgctt tagatgggtt tggctttttg 3793261 tgattatgtt gctgcttgct gagtgtcagc catcttattg ggtgttggag aaggatcgaa 3793321 tcggtgaagg cagtccagac ttagaaatat acgctaatta tctccaaatg catgatgacg 3793381 tgaaaggata tcaagtcttc accatatcag aaggcaaaaa aatggtcgtc gtgtctctcg 3793441 gaagcagcga gaaagataag aagcttgaag tgtcggacgt caaattctca tctaaagaaa 3793501 cgattgtaac tgtggagcga aaacctgctc ctacggcaaa tgagaaaaac ccttttattt 3793561 tgattggact ggacaaaatt gaaggggatt taattgttca agacgaaaca ggagatcgct 3793621 ttgaagaaac ggattaccag caataaagcc ggcgttctga gaacgtccgg ctttttcttt 3793681 tacttcaatg tcccatgcgg gtcgatgacg aattttttgg ctgcgccttt gtcgaagtcg 3793741 ctgtagcctt ttggcgcgtc gtccagagaa ataacggtgg cattgacggc ttttgcgatc 3793801 tgcgctctgc cgctcaggat cgctttcatc aaattgcggt tgtatgtcat ggcgggcgtt 3793861 tgtccggtga cgaaggtgtg ggctttggcc cagccgagtc cgaagcggat ttttaatgag 3793921 cctgttttgg cgtccgcatc ctttgcaccg ggatcttcgg tcacgtataa gcctggaatg 3793981 ccaaggctgc ctccgacctg ggtgacgtcc atgattgagt tcagcacggc ggctggcgct 3794041 tctccttgat tgccgtgccc agatgcttca aagccgacac agtccactgc agcatcaacg 3794101 gttggttcac ctagtatttg ttcaatttgc tcgccgaggc ggtcgtgttt ttgcacgttg 3794161 accgtttcac agccgaagct tctggcctgt gccagcctgt cttcgttcag atcgccgaca 3794221 atcacggtag aggcgcctag gagctgagcg gagtgtgcag ctgccaagcc gacaggaccc 3794281 gctccagcga tataaacggt tgaacctgtt tgcacgcccg ctgtataagc tccatggaag 3794341 ccggtcggaa aaatgtcgga cagcatggtc aaatcgagaa tcttttctag cgcctgttct 3794401 ttatcaggga ataccaaaag ctgaaaatca gcgtatggca ccatgacata ttcagactgg 3794461 ccgccgaccc agccgcccat atcgacgtag ccgtaagccg atcccggccg gtccggattg 3794521 acattcaggc acacatgcgt tttctgcgtt ttgcacatca cacagcgtcc gcaggcaata 3794581 ttgaaaggaa cggatacgat atctcctttt ttgataaatt caacatcacg ccccgtttca 3794641 atgacttctc ccgtaatttc atgcccgagc accaagcctt ctggcgccgt tgtgcggcct 3794701 ctgaccatat gctggtcgct tccgcaaatg ttggttgtaa tgactttgag aataacccca 3794761 tgctcacatt ttcgattcac attcgccttc gggacgccgg gcccgtccct caagattaac 3794821 tccggataac cgatatcctc caccgctaca gtccctttgc ctttgtacac aaccgctttg 3794881 tttcctgtca acgccattcc tcccattcat gtgtttggac tctccgtcct tgaacatgac 3794941 ttcggttcgg catgactctt tccctttttc acgactgttt tttctgtatt cttacaacaa 3795001 caaatatgcc aagaaagcat ccaataatgg ttccgccgat gtctaagaag tcgactttac 3795061 atccatttaa caagaacaca gtaatggccg aaaccaggca gatcataact gccagaagaa 3795121 taacccgatt tgtctgcatg taattcctcc tttggattcg tttctaaacc atacccaaaa 3795181 tcctctgcaa acttcggttc aacaaaaaaa gagacttcac accagtctct tcataaacag 3795241 agatcactca aaaaatttcc tgagaaataa tgtggcaaca ctcgttacta acgcaattgc 3795301 cgtatacata acaacccaaa atatgaatga gctattcccc gaagctaacg taactaacaa 3795361 tatcaagctc gtgataagaa cgatgagcgg tgccacccaa aatcttttaa ataaaaaatg 3795421 acccgctata ccaaatacac ctgcgacgat cggaaaacca aaaacgataa ataaaacggc 3795481 gatggctccc atactaccct ccttgcctta aaacctcttc atcacctcaa catcatacag 3795541 cttcaaatga ctcttcggcg tcacgacatc ctttaccttc ccaatctctt tttctttcat 3795601 tttctttccg gttttcaggc tgtactgttc aatgtaggca ggcttgtgat acgtgtatgt 3795661 gaagaaatag aggctgctgc ctttttgggt gatttctttg aattcggctt tcattttgtc 3795721 cggggaaagg gtgaagacga tgcttgtttt tcctgtcttg gcatcgattt tgtgtacctt 3795781 tccgaagccg tcaatgaaat acaggttccc gtcataaggg aaaaagctgt ttttaaagct 3795841 gaagggcatg gagctgtata tcgtttgttc gtcgtttttg tattcggcga tatcgtgcag 3795901 ctctacttcg ccgctttttt tgttgatctt gaccatttga tagagatcgt gggctttttg 3795961 gccgcgaacc ataacataca cagcttggtc gtccacggca agttgggatt cgactgaggc 3796021 tccttcccgg tactgccatt ccgttatgct gagataggta agcttcttct gatctgcttg 3796081 aatctgaagg agctgatagc cttttccgtc atctgtcggg acgagtgcgt aaatggcgcc 3796141 atcatggaaa ccggaggctc ggatgtagta ggggatgacg tcttttttcc actctccgtc 3796201 catttggcgg tacagctctg agcggtatcc gtctcccttt ttgtcgtagc cggagttgta 3796261 taaggtgtaa aagccgtccg tgttttgcag aaagcccgcg ctgtcgcctg tgtgctgata 3796321 ggttctttta tgggagcgca ggccgttttt gatcgtataa atcgtgtttt tgtcctccag 3796381 catcacgctg tcaccgtgaa cctttgctga gcccagctca aggcccttca tctgaaagga 3796441 agacagcgtc ccgtcatggc tgataaacag ggcgtagctt ttcccgccgc caaatgcatc 3796501 ttgatccgca gaggatgaga aatacagcag gacttctttg tcatccagga aatcgggatt 3796561 tctgagatcc tgctgactca cggttttatg gcttttgaga ggagaaatga agacaaatag 3796621 tgcgattcct gcgagaatca gcatggcgat ggtaatcatc cactttttca tagccttctc 3796681 cttagtaaat ggtcataatg gttgtcgtat aagaagaact agtgatgtcg cgcggataca 3796741 cgcctaagcc tccgttgctg tctatatcaa tccctgcttt cagcaaaaag gcagaccata 3796801 ggagctttga acagtttttg gcgccgtcat ggccggtatt tctgttattg acgaagttaa 3796861 atgagtatgg gtcgccgact tttgataccg cccagtcggc agcagctgtt ttttgagatg 3796921 aggatacgct gacggtttgc acaatggagt tgtcttccac gtctctggca ttatacgcga 3796981 tctgcctgac gccgtcgctc gggacagatt caacaatttt gtcagcggcg gagtacatgc 3797041 cgacatggcc gtgattgtag taggctgtgt aggagttcgt gtaatagata ttgcctttcg 3797101 cgcttgtcgg gagttttttc gtgccggacg agccgcccat gatagacatg ccgctttcct 3797161 tggcgagccg gtccccctct gctttatcag ccgtgatctc cttatagaac tgttttagga 3797221 taacgtcctg ctttacgtgc tgctgtttgg caatctggct ggcagatttc atgatttctt 3797281 ccggtgtcgt gcctggctgc agtgcggcga tttcttcagc ataatttgtg gtctttacgg 3797341 ctttggcggg agtaacaaac aggccgccgc acattgtgag cgctaccaaa aacatcgaca 3797401 ctcgtttctt caacttcatt acatctcctc ttttcttgtg agtgtaggaa aggtaatttc 3797461 ctcacccaca ttatattagg aaaataagga aagtaactag gttatttaca gaatttttag 3797521 aaatcgttta cagaaaaagg cctttatcag gcccttttcg ttaaagcttc ttgctcatca 3797581 ctacgtctgt ttcttgaaat ccggtttgct catatagctt tcgagccgtc tgattatggg 3797641 caaagacatg aagggacagc ttgcggattc ccatactgcg tgccgcttga tctaatgccg 3797701 ccaatgcttg ctttgcgtag ccctttcccc gatacggttc atataacccg aaatcataaa 3797761 taaacgcttc ctgctgcgga tgctccggtt cagcatgtat ccagagccag ccaacgatat 3797821 ccttttcatt cagcttgagg ctccacaaat ggtgatgggg tgtttcgagc cctctcggaa 3797881 gcagatcagt aaacacctgc ttagacaaaa gctgggcatc ttcaggcagc catgttcccg 3797941 cttttacctt ttcttccgcg taatgctttg ttgtgtacgt gagataagac cgaaattctt 3798001 ctgtctgcat aggggttagc ataattgtca tatcatctct ccttcatata ttgactagag 3798061 gattttacat aaaatagaaa gaggtgttac tatcagaata agcaactgag attgataagt 3798121 cactagagaa aggagtttca catgaataag atcgcacccg cagaaatcgc tagcatgctc 3798181 aacgattggt accttgccat caagaaacat gaagttgaag aatcctcccg tttatttgaa 3798241 gaagtgaagc ctttattgga tgacatggaa gaggatcagg aggtgcttgc ctacttctcc 3798301 ttattggaac tgcgccacaa ggttttgctt cacgaggcga gaggacaggg ctttcagcat 3798361 gaggagcctt ctcatatgaa tgctacgtct gacatgctga aatattactt ttttctgttt 3798421 gaaggcatgt atgaggccta taaaaataat tatgacattg ccattgggct gtataaagat 3798481 gcagagcagt atctcgacaa cattcccgat ccgattgaaa aagccgaatt tcacctgaag 3798541 gtcggtaagc tctattataa gctgggacaa aatattgtgt ccctcaatca tacacggcaa 3798601 gcagtcaaaa cattcagaga agagacagat tataaaaaga agctggcttc agccctgatt 3798661 accatgtcag gcaattttac agagatgagc cagtttgaag aagctgaggc ttatttggac 3798721 gaagcaattc ggatcacgag tgaattagag gatcattttt ttgaagccca gcttttgcat 3798781 aacttcggcc ttctacatgc gcaaagcggc aaatcagaag aagcggtttc gaaattagag 3798841 gaggctctac agaacgatga gtatgcccgc tccgcctatt attatcattc tgcctacttg 3798901 ctgatacgag agctgtttaa gatcaaaaag aaagaacagg ccttatctta ttaccaagac 3798961 gtgaaggaaa aattgactgc tgagccgaat agaatatgtg aggcaaaaat agacatttta 3799021 tatgccattt atgcagaagg gggtcatgcg gaaacgtttc acttatgcaa acaacatatg 3799081 gatgacttgt tgtccgagaa agagtatgac agtgtaagag aactttccat tttggctggc 3799141 gaacggtata gggaacttga gctttacaaa gaagctgccc acttttttta tgaagcatta 3799201 cagattgaag aactgattaa acgaacggag gttatataaa tgaaaagatt tctgattggc 3799261 gcaggcgtcg cagcggtgat tttatcaggt tggtttattg cggaccatca aacccactca 3799321 caggaaatga aagtcgctga gaaaatgatt ggataaatga aaaacccccg cgggatgcgg 3799381 gggttcaatt taacgaaaga atcctaaaac ggtttgtagt tttaggattc tttcatcttt 3799441 tcagcgtgat tgaaaaccct tgaagtctag gaagaacgag cattggagcg cagcgaatgt 3799501 ttggaattcg tgagcaccga agcgcaggcc tgacaacgaa tgcgagggtt tgtcgacacg 3799561 ctgaaacccc cgcgggtgcg ggggttttct tattacagca gcttcttccc taacagggat 3799621 tctacgagct ctactgctgt tttgcccgtt ttgtttttgt gatcaaggat cgggttaacc 3799681 tcaacgaatt cggctgaggt aatgatgcct gcgtcataca gcatttccat agccaaatgg 3799741 ctctcccggt agctgatgcc gccgacgaca ggggttccga cacccggtgc gtcgttcgga 3799801 tcaagtccgt ccagatcaag gctcagatgg acgccatcac atgctgataa ataatcaagg 3799861 gtttcttcaa tgacctttgt catgccaaga cgatcgattt cgtgcattgt gtacaccttc 3799921 atgccgcttt ccttaatgta cttgcgctcc ccttcatcaa gtgaccgggc gccaatgatg 3799981 acgacgtttt ccggtttgat tttaggcgcg tagccttcaa ggttaaccag tgactcgtgg 3800041 ccaatgccta ggctgaccgc gagcggcatg ccgtgaatat tgcccgatgg tgaagtttca 3800101 agtgtattca aatcgccgtg cgcgtcatac cagatgacgc cgagattatc gtaatgcttc 3800161 gctgtgcctg caagcgtgcc gatcgcaata ctgtggtcac cgcccaggac aagcgggaat 3800221 tttttctctt caatgacttt gttgaccttt tgcgcgagtt tttcatttcc cgccaaaacg 3800281 gaattcaggt ttttcagttc ctcgtcattt ttgatttttt cgcgattgat cggaatgtca 3800341 ccgagatctt caaccgtata ccccatgtct gacagcctct cgatcagatg agcgtaccgg 3800401 atggcactcg ggcccatatc cactccgcgt cgtgcttgtc ctaaatccat tggcattcca 3800461 ataaccgaaa tcgttttatc catctgtgat tccacctcaa catttaagat aatgtcctat 3800521 gcgggttata acaaagatga cttgcggaca acgtttttaa agctctagct gacgatttgc 3800581 ctgctggcgt tttttaatga cgacatgata aatgatgtag caaatgatca taaacggtac 3800641 gccgcaatac agcgcgatac gctgctccgg atcaaatgca agactgatga gcacgaccgt 3800701 atttaacgtt aggccgatca gcggaagcac cgggtacagc ggtgttttaa atttcaaatc 3800761 ttctatcttc ccgccctcac ggatatattt gcgtctgaac atgatttggg aaagcgagat 3800821 cgtaatccag ccgacctgcg cgctcatgcc cgccaaagat aacagtacca tatatacggt 3800881 ttcagcctgc gcaaactttg tcagaagtga taggcaggcc acagccatcg ttacgattaa 3800941 cgagtacatc ggtacaccgc gctgatttgt tttgccaagc gctttgaagg cttgtccttc 3801001 attcgccatc gcgtacagaa tacgtgttga tgcgtataaa cctgagttcg caacagataa 3801061 cagtgcgatt aaaataacaa agttcatgat atcagctgca tatgggattc cgatttgctc 3801121 aaatacggca acaaatggac tttccacgac acccgcctgt ttccacggaa tcatgccggc 3801181 aatgacaatg attgaaagca caaagaacac aagcgttctc catactgtct gtttgatgga 3801241 ccgcggaatc gttttttcag ggtcttcact ttctccggct gcaaccccga tcagctcagt 3801301 cccctgaaac gcaaagttca cagtaatcat cgtaatcagc attgccttta tgccgttcgg 3801361 aaataacccg tcttcataaa aatgtgtcaa aaacggcgcc tgctctccgc ccttcagatc 3801421 aatcaggcca aacatggcag ctccgccgag aataataaat aaaaggataa tcaaaatttt 3801481 aatgcctgag aaccagaatt cagattccgc aaaggctttt gtggtgatcg catttaaaat 3801541 aaacatcagt gccgcaaaga ccagacacca gatccacacg tctatatgcg gaaaccagcg 3801601 ttgcatcagc tgccccgctg ataaaaattc aatggcgcat gtaaccgccc agccgagcca 3801661 gtacagccag ccgaacgcaa acccgaaggc cgggctgata aatttcgtgg cataggtctg 3801721 gaaggacccc gacacaggaa aggcgactgc cagctctcct aagcagagca tggtcaaaaa 3801781 catgataaag ccgcccacta aataggacag aaccgcgccg agcggtcccg cttggttaat 3801841 ggtaaacccg gttccaagga agaaaccggt tccgatcact ccgcccaatg aaatcatgaa 3801901 caaatggcgt gatttcattg tccgctggag ctgatttccg ttatcttggt ttgtattcac 3801961 attctgcacc ccttcagcaa cttgtattgg atctaagctg gaacatctgc atggtgctat 3802021 cccagtttgc tgtccaaaga gtctctatct atttaatata aaattcactt cttctcataa 3802081 agatacatta tactaaaata ctgtagctga gcaaataggg agtgctgatt tttctgttgt 3802141 aaatttatac aaacgaagtg aatatcccgc catggtgcgg atttatgcgt ttcgcagcac 3802201 gtgcttaatt ttctctatcg cccaatccaa gtcctctttg gaaatgatta atggcggtgc 3802261 aaaacgaatg actgtatcat gcgtttcctt gcataaaagt ccctcttcct tcaaacgctc 3802321 acaatacgga cgtgccgctt cagtcaattc cacaccgata aacagccctc tgccgcggac 3802381 ttctttaatg acagggctgt caatactctc aagctcgctt ttaaagtatt caccaagttc 3802441 aagagaacga tccgccagct tttcatcctc cagcacttct aatgaagcga tagacactgc 3802501 acatgcaagc gggtttccac caaatgttga gccgtgtgag ccagggttaa acacgcctag 3802561 gatctcgcgg tccgccgcaa tgcaagagat cgggaacaca ccgccgccaa gcgctttgcc 3802621 caagatatac atatccggaa caatgccgtc ccagtcacag gcaaacgtct tgcctgtacg 3802681 tccgagaccc gtctgaattt catccgcaat aaacaagaca ttctcttcct tacaaatcgc 3802741 cgccgcttcc tgtaaaaatc cttcaggcgg aatcacaatg cccgcttcgc cttgaatcgg 3802801 ttcaaacaag aatgccgctg tattcggcgt aatggcctgt cgaagcgctt ccacatcgcc 3802861 gtaaggaatg agtttgattc ctggaagcat cgggccgaat cctcgtttat attcctcttc 3802921 agaagaaaga gataccgcca gcatcgtgcg gccgtggaag ttcccgacac atgcgataat 3802981 ttccgcttga ttgtcagcta cgcccttcac ttcatacgcc cagcgtctcg ccgctttcac 3803041 cgcggattca accgcttcgg ctcctgtatt catcggcaga atcatctctt tgcctgtcag 3803101 tttagctgtt ttttcgtaaa acggcccaag ctgatcgtta tgaaacgcgc gtgacgtgag 3803161 ggtgatttta tcagcctgat cctttaatgc ctgaatgatt ttcgggtgtc tgtgcccctg 3803221 gtttaccgca gagtaagcac tcagcatatc catatattca ttgccttccg ggtcctttac 3803281 ccaagcaccc agcgcttcag aaataacaat cgggagcggg tgataattgt tggctccgta 3803341 atgagacgtc tgatcaataa tttctttgga tttagataaa gctgtcatat ttgaattccc 3803401 ccttgttttc tgtttcaaca tgttatcctg ctttcccttt atataaatgc aagttctgtg 3803461 ccaaatcaag aattcgtgtg ttttctacaa ttttcgagga caaggtgcaa aaacattctg 3803521 atatttcgag cgaaaatttc agcaagtgca aaattctttt gcatatcctc tccgtttttt 3803581 tataaaatag aagcaatatt aagaaaataa ttgagggagg ttcatacagt ggtcaaagac 3803641 agcgaattcc tcacattggt ttttcagagt attttagatg aaatcgatgt tggcctgcac 3803701 gtggtagacg agcatggaaa cacaatcgtt tataacaata aaatgatgca gattgaagat 3803761 atggagaagc atgacgtctt gaataaaaac ctgatggatg tgtttatgtt ttcaaagcag 3803821 caggacagca cactggtaca ggctcttcag gaaggcaaga cgattaaaaa cgtcaaacag 3803881 agctatttca ataataaagg ccaggaaatt acgacgatca atcatacata tcccatcgtc 3803941 caagacggca aaatcagggg cgccgttgaa attgccaagg atgtgacaaa gctggaacgg 3804001 ctgatcaggg agaatatgaa caaaaaaggc agcacaacct atacgtttga cagtattctc 3804061 ggcaccagtc cggccattca agacgtcatc gaaaacgcca agcgggcaac ccgtacgtca 3804121 tcatctgtcc ttctagcagg cgaaaccggc acgggaaaag aactgttcgc gcaaagtatc 3804181 cataatggaa gcgatcgttc tggcggcccg tttatttcgc aaaactgcgc ggcactgcca 3804241 gacagccttg tggaaagcat tttgtttggg acgaaaaaag gcgcgtttac cggcgctgtc 3804301 gaccagcccg gcctgtttga acaagcccac ggcggcacac tgctgttaga tgaaatcaac 3804361 tcgctgaatc tcagccttca ggcgaagctg ctgcgcgccc ttcaagaacg gaaaatcagg 3804421 cgcatcggtt caacaaagga tacaccgatt gacgtacgta ttattgccac gatgaatgaa 3804481 gacccaattg atgcaattgc aggcgaacga atgcggaagg acttgtatta caggctgagt 3804541 gtcgtcacac tgatcatccc gccgcttcgg gaacgaaaag aagacatttt gcttctcgcg 3804601 tcggagttca tccagaaaaa caaccatctg ttccaaatga atgttgaaca catcagcgat 3804661 gacgtgaagc aatttttcct ttcttatgac tggccgggaa atattcgcga gcttgagcat 3804721 atgatcgaag gcgcaatgaa tttcatgacg gacgagcaaa cgattacggc ttcccatctg 3804781 ccctatcaat accgcatgaa aatcaagccg gctgacatcc cagagccgga aacaccaaga 3804841 caccagccag ccgcggactt aaaagaaaaa atggaaagct tcgaaaaata tgtgatagag 3804901 aacgtgttaa gaaaacacgg ccataacatc tcgaaagctg ctcaggagct tggcatcagc 3804961 agacaaagcc tccaatatcg gctgaagaaa ttttctcact cgtctaacga ataatccgga 3805021 gcaggaagcc tgatcagaaa aacagtgcct ctgccgattt cacttttcac ttcaatcgtc 3805081 ccattgtgat tgtcgataat cgatttcgtt atggcaaggc ctaatcccga acctccatat 3805141 ttccgggagc gggatgggtc tgccttgtaa aaccggtcaa acactaaaaa acgtcacttc 3805201 ttatgcattg aagaaagaaa atggcaccta tgtgtatcac agccagcaac cacacggtac 3805261 aaaccattaa agtccatgca aataacggaa gtatttgcag ctaactgcca tttgctgttt 3805321 cacgtgtaac atccatcttg tatttttctt catattcgat atatcctttt tcaactgaac 3805381 gggcgtgacc cctgttcagt tttttttgca tatcaaaaca gcctggcaac gatgccagac 3805441 tgcttttatt aactgcctaa ttggtctgcg gaggacagct tgatatcaac agatttttct 3805501 tttccgccgc gataaaactt caccttcacc cggtcaccga cttttttctg ataaagccgt 3805561 tttcgcaggt caacaatatc atttactttg tatccgtcaa attccgtgat gacatccagt 3805621 tccttcagcc ccgcttttcc ggcaggtgaa aaggcgtcta cacccatcac aaccgctcca 3805681 ttggtgacgt tcttaggaag ctttaatgtt tcatcccaat gatagcttgc gatgtcactt 3805741 agcgatttca tctcaatgcc aaggaacggg cgtttgacct ttccgtatct ctctaaatcc 3805801 tctatcacag ggatcacgag cttagacgga atggacaggc caatcccttc aaccgctgac 3805861 tcggcaattt tcattgaatt gatgccaatg accttcccat ccatatttaa caaagcgccg 3805921 ccgctgttcc cagggttaat ggccgcatct gtttgcagga cttcagcgtt ccagtcaggc 3805981 tgtccatcac cgtttgaatc tactgggatc gccctctccg tacccgagat gacgccttgt 3806041 gtgacagagc ctgcaaactc aaggcctaac gggttcccga tcgcaataac cggctcccca 3806101 gacttcactt tatctgaatt tccgaaatca gcgactgctt taatcttatc gcttttcacc 3806161 cgtaaaacgg caaggtccat cagctggtcg ctgccgacaa gatcagctga tacacgtgag 3806221 ccgtctttca agctgatttc aatttgggaa gcgccttcga tgacatgatg gttggtcacg 3806281 acataagcgg aatggtcatt tttcttatag atgacgccag agccgctccc agcctcgccg 3806341 ctctctcccc aaatatctga tttttggatg ttcacaacac cgacaacggc gggcgacata 3806401 ttgctgacaa tcttggtgac ggcattgttg acactgacat tcaccgtcct gattgattcc 3806461 cggccattgt tgttttgctg ctgatctaag gcgcctgtat ccagcccttc atttgaaagg 3806521 tacggcatga taaacgccat taatacggca ccgacaatca cgccaatcag actcgaaaga 3806581 aaatatcctt ttttgcttct ctttggctgt tcaggagtag tatgttcttc ctcacgttcg 3806641 taatccacca tattccatcc tttccaagaa cgttaatatg gttatattgt gggttagaaa 3806701 ctcctagaat agtcatgatt tacatagaaa aattatacag cgcaaagcgg agtggccttc 3806761 ttcggatcgg tgtcgtataa gtcaaatgtc tcacccgtca caaatccttt agaagccaat 3806821 gtctgctgca cagacattct tgccagctcc ttcatgttgt tgtcctggct caaatgcgcc 3806881 aggtaaatac gagacgtctc atcgccaatg acatccgtca tcgccaaggc agcatcttca 3806941 tttgacacgt gcccgacgtc acttaaaatc cgccgcttaa tgctccatgg gtatcttccc 3807001 atttgcagca taccgacatc gtgattgctt tcaaacacaa atacattcgc tgaacggata 3807061 atgcctttca tccggtcgct gacatatccc gtatctgtca ttaacgcgag ctttcggccg 3807121 ctataatgga atacataaaa catcggttcc gccgcatcgt gggaaacgcc aaacgattca 3807181 acatcaagtc cgccgaacga cttcaccgtc tccattggaa atacaaactt ttgatcggtg 3807241 tcaattttgc cgatttgatt ctccatcgct ttccaagtct tctcattcgc atagatcgga 3807301 agcttgtact ttctggcgac gacaccaagg cccttaatat ggtcactatg ctcatgcgtc 3807361 acaaaaatgc cgtctacatc atccagctta cgcccgatct gcgccatcag cccatccatg 3807421 gcttttccgc tcaaaccggc gtccactaaa aatgcgtgat cctctgtttc gaggtaaaac 3807481 gcatttcccg tactcccgct cgcaagtacg ctaaattgca agctcatgtt tgtctcactc 3807541 cattattttc attgatctgt atctaaaatc gtactctcca aagcattcac agtaaaatac 3807601 tcttgtactg tctttttctc accgttcact tttttctcgt actcgaccgt aattctccat 3807661 accggcgcca gcacctgcgt acttgtcagc ggatattgtg ctacatagcc gaatttacag 3807721 ctcttcacag tgctgtattc ttttaattga ttttgatagt acaatagctc aaccgcatcc 3807781 atttcagtaa ttaagctttc tttctggatt tgcttgaagg tctcaagcgt agtctggtcg 3807841 tatgacacaa cctcgttttt accgtttaag tgcagcacca cttgcccgat catattagag 3807901 ggattgtcgg tcttttggta aatataatga ccttcgtacg tttggaagaa aataatttct 3807961 ttcttcgatt tatcaacctt ccaaagctta tatttttcgc catcttgaat tttcgaagaa 3808021 acaagtgcct gagcatcgtc ctcgatatcc ttctttgata gtgcgattgg atttgcaaac 3808081 ttcattttca ggctcgttac tttatgatca tcactaggca tgtccatcaa aggcttttga 3808141 tccttcagcg cctcaatttc ctccttggag aaagactttt gatttgccgt gatccgatag 3808201 ccttctgttg cttccttatt caagccttca tacgtgatat gatcggcctt catgtcatgc 3808261 tcgacatcat ttttaatgac ttcatattct ttgccggtag cctgccattt ttgaaaaaac 3808321 tgatagccta agaaaatatc taaaatgagg aaggcaacga tgaagattga ttttgtctta 3808381 ttccactcca ctgttagccc cctccttcct caataaatcc tttgtaatcg gcacaatttt 3808441 tccatttact ttcatcgccc aaaccggttc cagttcaacg agaggatcat cgttggttga 3808501 tgttgatacc aattgataag caaggaagat ctgatcaatt ttgtccgtat cataagcggt 3808561 ttgtttcgaa agcagcatct tcacttcgct gccgcccatg agctctgttt cacttgtttt 3808621 aatcggattc gttccgagac tgtaattcgg ccgcttatag ctgagaatat catcattcgc 3808681 ccattgcacc gtaatcgccg atgtcgcccc gaaaggtttg gcggtgctgt taatgaccgg 3808741 gatctgatcc ataaaaatat agaagctcaa ctgctggctg tcattgatat tgaaaaattg 3808801 atagtgatcc gtccagcttc cggtatcctc aaggtatttt tggctctttt tgattaattc 3808861 acctgtttga taggatgtgc tctgcaccaa attgcgctgc tgaaattgca cctgtctctg 3808921 gcttagattc acatctaacc ggctgatccc atctgtcagc acatttctgt tggtgtaatt 3808981 cgaatcttct cttacaatgc tcggatcact aaacaaagcc tgcttaaagg tatttgtttt 3809041 aatcgattct gtgacaaatt cttttttgtc catcgtaagc ggtttgttcg gcagcaagaa 3809101 ctctttcttt gagccaatgg agaacaaact gaacgccggc atatttgatt gcctgttttt 3809161 caagtcgttc ataatgttcc ggtagtttgc tgattcaacc gtcacttcaa gaatgagctg 3809221 cttgctgtat gacaccaaat agattttctt gttcgctttt gtttcattga acgggatcag 3809281 aatatggtca aacgaactgt attcaaacga ctgattagac catttaaaca gcgtttggaa 3809341 aatatcaatc gggatcgtat cgctgaattg caagtcaagc ttggcttcag aaccgcctat 3809401 tccataaaac cagcttttga atccagcctt gtcatactga tccgaaatat ctttaattcc 3809461 tttcacatcc caatgcggca agtcagacca aatttcttca tagagggcat tgtcatccac 3809521 tttgtaatga gcgccgtcat catggataaa catgtccctt ggccttaccg tttcagacag 3809581 cttttgggtg gttttttcga ttttatgttt cacacgaaca gtagactctg ttgaggatga 3809641 gccttcagaa aagtttggct ggaacgtcca tatcccccat gtaaaaacaa gactgatgac 3809701 gacgagtacc gtaagtaata tcgtttttat attttcacgc ttcatcccaa tcatcctctt 3809761 gttcctcttt atatggaaga gtaaatgtaa tcgtcgtgcc ttttccttct atgctgtccg 3809821 cccaaatatc tccaccgtgc gcctgtacca tttccttggc aatcgccaat cccagaccgg 3809881 tgccgccaag ctttctcgtt ctcgctttat ccaccctgta gaagcggtca aagacttttt 3809941 cgacatcttt tttcggaatg ccgatccctt catccttcac gctgatatag agaagttctt 3810001 cctcttcatt gacatcaatc gagaacgtga catgtccgcc ttccggtgaa tattttaaag 3810061 cgttagaaat aatattatcg agcacctgcg ttattttatc ctggtcaatc tcgacataca 3810121 gatctctgtc cggcagattg cggataaact ccacatgctg ctcttttgtc atttcaaaac 3810181 ggtcaataat aagtgacata aaccggacaa tctgaatcca ttcccggtta aattgataat 3810241 ctttactgtc aaatttcgac agctgaagca gatcattgac aagccggatc atacgctctg 3810301 tttcattttg cgtcaccatt aagaagcgcg gagcaatgtc tttattttcc cacgcgcctt 3810361 cagctaacgc ttctaaatag ctgcgcattg tcgtaagcgg cgtccgcagc tcatgtgata 3810421 cattcgcaac gaattctctg cgttcctgat ccattttctc ttgttcggtt acatcgtaaa 3810481 tgacagcgat taaaccatca attttgccgt gttccctttg aatcacagag aaattcacgc 3810541 gaagcaccgt taattcatca tcgcgctcaa tttcaagcag catagaatcc tgctgttcca 3810601 ctaaatcttc aaaagtataa ttctcttgaa gccccagcaa actcgtaatc ggcatttcta 3810661 aggctgtttc acgtgaaacg ttcaacagtt ccagcgccgg gctgtttaag agaataatcg 3810721 ctccgtttcg gtttgtggcg ataacgccgt ctgtcatata agcaatgaca gaggctagct 3810781 ttctgcgttc tccttcagtc atcgcctggg catcttcaag ctctctcgtt aagtggttaa 3810841 acgttgtggc cagctgccca atttcatcat gtccatactt tttaaccttc ctcgagaaat 3810901 tccctttcgc aagctccatc gcctgctttc gcatatctga aagcgggtgg gtaatggttc 3810961 ttgccagaaa aataccgaga agagccgtca aaacaagtgc caaacctgtg ccggacgcca 3811021 gtatcgtgtt gatcgtcttc atttgattaa agacatcttc catactcgcg acaacgtaga 3811081 tcgcgcccac aacctcttgg ttttcagtca tgacgggctt cgcggaaata agaactctga 3811141 ttttgctttt cgggtcataa tattttctta aatacgactg tttggtagaa aagattcttt 3811201 tgaaaatcag atcggtcgtt tgtttcccag ccacttcctc accgtacggc tttgaagaac 3811261 cgaccacttc atagctttta tctacaaagc taatttcccg aacctcatca cttttcgtga 3811321 agtcattcaa aatacggctg acgtcatcct ttatgacggt actgtcgtta tcgctcttat 3811381 attcttgttc gatataataa gaaaggttgt cgattcgctg attcagcgat tgttcataag 3811441 agctgatcag cgacttctct acctgattga caaaatacac accaatgatt tgcatggcaa 3811501 tgataatcaa aagcacataa atcaaggtaa tcttaaattg gatcgaccga aaaaaaccaa 3811561 ccttattcat atgggcatta gtcctgttct gggtttctca agtaataacc tacaccacgg 3811621 cgtgtgacga tccaatttgg atggctcggg ttgtcctcga ttttttcacg aagccggcgg 3811681 actgttacgt caaccgttct gacatcgccg aagtaatcat agccccaaac ggtttgaagc 3811741 aaatgttcac gggtcatcac ttgtccgata tgttttgcta aataatgaag caattcgaac 3811801 tcacgatgag tcaattcgat tgtttcgtct cgttttgata caacgtacgc gtcagggaag 3811861 atgacgagag agccgatatg aatctcgtta gaggaaggct cttcctccgc aggcgctgtt 3811921 gtcagctggc ggcgcaggtt cgcttttaca cgcgccaaga gctcgcgtgt gctgaatggt 3811981 tttgtgacat agtcatcagc accgatttca agcccgataa ccttgtcaat ttctgaatcc 3812041 ttagccgtca gcataatgat tggcatatcg tatttctttc tgacttcgcg gcatacttca 3812101 acgccgtctt tatttgggag cataatatct aaaagaatta aatcaggctg aagctcttct 3812161 accatttcaa cggcttcgtt tccgtcgtgg gcacagtgca cttcatagcc ttcttttctt 3812221 aagttaaatt ccaatatatc tgcaatcggt ttttcatcat ctactacaag gatcttttta 3812281 tccatcattt tgattttcct cctgccgaat gacttcattt catctatata acattcgttt 3812341 catcacttat ggcccatgta aagaatgggt ccttgtctat tataacggtt taaggtcaaa 3812401 agataaaaaa aataaaggtt tagaaaaaaa acacatgttt cacctttatc gccagttgtt 3812461 tatctattgt catgctggtc aacttttttt aaaaaagata actttattga aacctcccct 3812521 caccggagtg cgtctttatc aatgacgtct tcttctttga accggccgca gggccggttc 3812581 tccctttttc ttctattata acactcctca tgtttgcctt tttcctaaaa gaaaaaacgc 3812641 acctacgatt gcagatgcgt ttggtaagtg gctcgggacg gaatcgaacc gccgacacac 3812701 ggattttcag tccgttgctc taccaactga gctaccgagc caaatgtttt atttttctct 3812761 actaagtaaa gtaaaatggc ggtccggacg ggactcgaac ccgcgacctc ctgcgtgaca 3812821 ggcaggcatt ctaaccaact gaactaccgg accttacagt aattgcccgg agagctgtcg 3812881 tgtcagctct cacagacaaa taaggaattt agcaataacg ctaaagtaaa tcaatgaccc 3812941 gtacgggatt cgaacccgtg ttaccgccgt gaaagggcgg tgtcttaacc gcttgaccaa 3813001 cgggccttca cgaaatggtg agccatgaag gactcgaacc ttcgaccctc tgattaaaag 3813061 tcagatgctc taccaactga gctaatggct cttaaagatg tcggaatttc tatagagcaa 3813121 acgacttaaa tctagttctc atcttgtact ctattgaagc agtttccgta acaacgagat 3813181 ttataatatc acgaacaaat agaagtggca ataacttttt tggttttttt tcatattttt 3813241 ttctcagacc aacttatatg cggctttcaa acaaaaaaca agccccttaa ataggggctt 3813301 gcagacatat tctatttagt tcgcacggta cacactgcga aggacatttg tttgtgagcg 3813361 gtctggaccg acagagaaaa tagaaagcgg aatgcctgtc agctgagaca cacgctcaag 3813421 ataatggcgc gcattttccg gaagctcgct caagctcttc gcacctgtaa tatcctcagt 3813481 ccagcccggc atttcttcat ataccggctc acattcagca agtgccttaa gacttgctgg 3813541 gaattcttca atgatttcgc ctttgtagcg gtacgccaca cagattttca acgtttcaat 3813601 tcctgctagg acgtcaattg agttcagaga aagatctgta attccgctca cacggcgggc 3813661 gtggcggaca acaacgctgt caaaccagcc gacacggcgc gggcggcctg ttgttgttcc 3813721 atattcgcgt ccgacttcac ggatttgatc gccgatttca tctttcagct cagtcggaaa 3813781 aggaccgtcg ccgacacgag tcgtatatgc ttttgataca ccgacaacgt gcttgatttt 3813841 ggtcgggccg acaccagaac cgatcgtgac accgccggca accgggttag atgacgtaac 3813901 aaacgggtat gttccttggt cgatatcgag cataacccct tgtgcgcctt caaataatac 3813961 acggcgccct tcatcaagag catcgtttaa gacaacagat gtatcgcaaa catacttttt 3814021 aatctgctgt ccgtactcat aatattcgtc taagatatcc tcaagtttaa acccttctgt 3814081 ctcgtacatt ttctcgagaa gacggttttt ttcttcaaga ttgcgctcaa gcttttccgc 3814141 aaacgcgtca cggtctaaca gatccgcgat gcgaattccg atgcgggctg ctttatccat 3814201 gtaagcaggg ccgattcctt ttttcgttgt gccgatcttg ttagcccctt tacgctcttc 3814261 ttccacttca tccaatttca aatgatacgg cagaatgacg tgagctctgt tgctgattct 3814321 caggttatct gtactcacgt tgcgctcatg aagatacgca agctctgtga ctaatgcttt 3814381 cggatctaca accattccgt ttccgattac acacgtttta tccttataga aaattccaga 3814441 cgggattaag tgaagcttat atgtgattcc gtcaaacttg attgtatgcc ctgcgttatt 3814501 tccgccttga taacgggcga tcacttctgc attttctgat aggaaatctg taattttacc 3814561 ttttccttca tcgccccatt gcgtacctac tacaactact gaagacatgt ccgtgcacct 3814621 ccgttaacct ttcaaaacga ttctattcaa acaaatcaag tttatcagtg aagaaacaga 3814681 aagtcaattg taaatccgaa cattaattta ttgtaaatct atattcgttc gcttccattc 3814741 gttttataag cgttttctca ctgctttgtc ataaaaagct tgcgaaactt tcatccttta 3814801 gcataagaaa gaatcacttg cctgatatcc cttttgaatt cataaaaacg atccgccagc 3814861 cgtccgggtc ctctatcgtc acgcccccat tgctccagta cgggttctct gattcgacct 3814921 cttgatagcc catgtgcttt agctttgaag tgatcgctgc cagttcaact gcattcggca 3814981 cataaaaaac aagaaggctg tcgggatggg gaacgggggc agtgcttccc ccttcatact 3815041 gggtgaattc caaatgataa tcggcatgag gaaggccgaa catgacaccg tcatacccgt 3815101 tatgctgtga aaattctcct attcgtttca aacacagtcc ctcttcgtaa aaacgaataa 3815161 tctcatcaag ctggcccgta ggacgcgcaa ttcggatttg tgctgcttga aaagacgaaa 3815221 aacgttttcc catattgtta ccatctcctt tttgcaccat tttattaaaa cgctttcaat 3815281 ttttcatccg ctgagcgaac gtcatttctt ccatctttcg aatgaaaaaa accccaagag 3815341 cagctcttgg ggcttatgcg ccgggcggaa cgcctgcgtc atcaaaacgc cgttccaggt 3815401 tgacgaattt gttgtattct tttacgaacg caagagacac ggttcctacc gggccgttac 3815461 gctgtttggc gataataatt tcgataatat ttttattctc ggtttctttg tcatagtagt 3815521 catcacgata aaggaacgcg acaatatccg cgtcctgctc gatacttcct gattcccgga 3815581 tatcagacat catcggacgt ttatcctgac gctgctcaac acccctggaa agctgagaaa 3815641 gcgcgataac agggacttgc agctccctcg caatcgactt cagttcacgg gaaatttcag 3815701 atacttcctg ctgacggttg tcctttgaac gaccgcttcc ctgaatcaat tgcaggtaat 3815761 cgatcaaaat catgcccagc ccgctttcct gcttcaagcg gcggcacttg gcacggattt 3815821 cactcactcg aatacccggt gtatcatcga tgtaaatccc gctgttcgat aggcttccca 3815881 ttgccatcgt cagcttgccc caatcctctt cggtcaggtt acctgtacgg agattctggg 3815941 cattgatatt tccctcggca cagagcatac gcataacgag ctgctcggca cccatctcaa 3816001 gactgaaaat cgctacgctc tcatcggtct tcgtcgccac gttttgtgcg atgttcaggg 3816061 caaaggctgt tttccctact gaaggacggg cagccacaat gatcaagtcg ttgcgctgga 3816121 aacccgcagt catccggtca agctccgtaa accctgttgg aattcccgtg atatcacctt 3816181 ttcgattgtg aagctgttcg atattatcat aggtctggac aaggacgtcc ttaatatttt 3816241 ggaaggcact cgtgtttttg cgctgtgcca cttccataat cgttttttcc gcttcactga 3816301 gtaaatcctc gacctcatcc tcacgggtat acccgtcttg agcaatcgtt gtcgcagttc 3816361 tgattaatcg gcgaagaatc gatttttcct caacgatttt cgcgtaatat tctatgttag 3816421 ccgctgtcgg caccgagttt gcgatatctg tcaaatatga aataccgcct acttcttcca 3816481 gcaggtctgt gttcgcaagc tctgatgtaa ctgtcaccag atcaaccggt tcacctcggt 3816541 caccgagcac cagcatcgca ttatagattt tttggtggga cattctatag aaatcatctg 3816601 gaatcaatac ttctgaagcc agtgttaaag cagacggctg taaaaaaata gcgcctaaca 3816661 cggcttgttc ggcttctata ttttgcggag gaagccggtc attcagaagg tctgtcatgc 3816721 taagcaccgt cctctcatta aaaaatctcc aacctccatt ctaccatttc tacagaaaaa 3816781 aaatagaaaa attgtctgtt tcctgttttt ttcagttagc agattggatc gtttcggaca 3816841 gtaacaaggc gggaaaaatg caataaaaca taagggagga atgaaagatg ataaagaaat 3816901 atgcgattac acctaatgtt gatgcggacg gctggtttat tgaggtggag aatgtagcgc 3816961 cgacagcttt gtatacgtct aaagacgccg ctattgaaaa ggccaaacag gtggctaagg 3817021 aaaacagtcc gtctaagctt gtaatttatg accagtttaa aaatgtggaa gaagaacact 3817081 cattttaatg aatgaaagcc ttcgctgcag cgagggtttt ttagcggtta tcggtttatt 3817141 tcatccattg gatgcctatg tgcatcatca aatctgccgc tttttgatac agatcccact 3817201 ccccgatcga agcaaatttc cccatcagct cctgaagctt taacctcatt gctatatatt 3817261 cttcgaaagt gacagctttt tcagtgtcta tttggtgttc cttcagcatt tgttttaata 3817321 aggataacgg tgcgtgcata agaaccctcc ttacctcttt tataacggtc attttccgat 3817381 tgctctattc ctttgtgaca tcttcttaca tttcacatct gattcttgta caatggacag 3817441 aagagaggag ggatcttttg tgagaccttt gcaaatttct gccgaaactg cacaaaagct 3817501 tgcagagtcc ttgaatctgc cgcttgaaca gatcatgcat atgcctcagc atattctgct 3817561 tgccaaaatg gctgaactgc aaaaagagga caaatcatag ccttcattca catacttgct 3817621 tacctgtttc gggataatat catgtatatg ttagaaaaga ggagtaactg ctttgccaca 3817681 tccacataat aaaaaaatcc aatcattttg gctgatcacc ggcattatct ttatcgcctt 3817741 taacttacgg cccgcgatca cttcagtcgg tccggtcatc agctctatcc gggcagagct 3817801 gcacatgtcc aatggggcag ccggtttttt gaccgcactg ccgctgcttt cgtttgcagt 3817861 tctttctccg cttgcaccta agcttggaca gcgcctcggt aatgagcgaa ctttatggct 3817921 aggtctcgtg atactgctga tcggtgttct gactcgttct accggctata ctgccgcttt 3817981 gtttttcgga acagcactta tcggcgtcgg gattgcgatt ggtaacgtac ttttgccaag 3818041 cttaatcaaa cataaatacc ctgaaaagcc agggatcatg atcagcctgt atacgacatc 3818101 aatgaatata ttcgcagctt tagcatcggg tgtcagcgtt cctttagcga cccagatgaa 3818161 tggcggatgg aaacaagcct ttctcttatg gggcgggctg gctttacttg cattgctaat 3818221 ctggatacct cagctgcgcc atcgagatac ggcaaaccag acaatgaagc tgcaatccag 3818281 ttccatttgg gcttccaaaa tggcatggta tgtcaccatc tttatgggcc tgcaatcgtt 3818341 tttattttac agcagcatcg cttggtttcc tgaaattctc cgttcacacg ggattgatac 3818401 ggcaacagcc ggatggatgg tatcactcat gcaatttgcg agtctgcctt ccacttttct 3818461 gacgccagtt ttagctgacc gtgtgaaaca gcagcgcggt atcgttgcgg cgctggcctc 3818521 agtttatctg atcggccttt gcggattatt agcgggcgga agccatacat tgcttgccat 3818581 ctggatgatc attatcggta tcggacaagg ctccagcatt agtctggccc ttactttgat 3818641 tggtctccgc agtgaaaatg cccaacaggc cgctgcgctg tcaggcatgt ctcagtcatt 3818701 cggctacctg ctggcagcag tcgggccaat ctttgtcggc tatctctttg accagacgca 3818761 ttcttggacg atgccgattg tgcttctcat tgctgccctg atcgtaatgg gagcagccgg 3818821 acagggagcc ggacgagatc gatacatttt ccagtcagaa aaacaaagaa attcagcata 3818881 aagcggggaa gatatctccg cttttttctt tgaatattta tggtttattc ataagttttt 3818941 catatttgtt ttttacaatg agacaccata aagaggtgaa aaacgatgaa aaccaaacga 3819001 ttcgacgcag cccttattct tattttgcta gcagcagctt ttttgaatac gtatcacatt 3819061 tggcaggatg atacagcaaa ccagtactat ttggcggctg taaaaagcat gacgcaaagc 3819121 ttccataact ttttttatgc gtcatttgac ccttctggat ttgtgacagt agataagcct 3819181 cctgtcgtgt tatggattca aacgattttc gcactgattt tcggtgttca cacgtggagt 3819241 gtcatcattc cccaggctct tgccggagtt ggatctgtct tccttctcta cagaatggtt 3819301 aagccgactt ttggagttgg agcggcccgc attgccgcac ttgtcatggc actgacccct 3819361 atcgcagtag ctgtcagccg gacaaacaat atcgacagca tgcttgtttt taccttattg 3819421 ctcggttcaa cttgtctgct tagggcagta aaacaaggca agctggtttg gctgctgacg 3819481 gcatttgccc tgattgggct cgcctttaat atgaagatga tgcaagcgtt tatggtattg 3819541 cctgcatttg tgttattcta cctgattgca tctcgggttt ctctgaagaa aaaaatcggg 3819601 tccctgcttc tgtctcttgt ccttctgaca ggcctttcac tctcatgggc gattgcagtg 3819661 gattcagcct cttcctcaag ccggccttat gtaggaagca gccagactaa ctcagtgcta 3819721 gaactggcct ttggctacaa cggcacagag cgtctgtttg ggcaaactac gggccttgca 3819781 aagggtgata tgaatgctgc tggcggaggg aacatgcaga atcaagacaa catgcaagcg 3819841 ccaaatggca acggttcatc tttttctcag aacggtaatc aatcattcgg aaaccattca 3819901 caggcgcctc agccgcctaa cggacaaacc ggcgctctca atggaggcgg aggcacacct 3819961 cccacaggtg gcaacggacc tggaaatgga gggcctggcg gcggaggcgg aaaaagcgtg 3820021 aatatgttcg gcaccggtga tcctggaccg cttcgtctct tccaatcagc actttccggc 3820081 caaatcagct ggatgcttcc attctcattg atcggattac tgggcgcaat catcagctgg 3820141 taccgtgatc gccgcggaca tgctgctaaa atgaaagaaa cgctattctg ggcggcttgg 3820201 cttgttcccg tggctggttt cttcagcatc gcaggattct tccaccagta ttatttgatt 3820261 atgctggcac cgccgattgc cgccctttct ggtatcggat ggtatacgat gcaccgctta 3820321 tacaaaaata ataaagactg gtccagctat cttctgccgg cagccgtctt gatcacagcc 3820381 gtgtttcagg tgtatattct gagcgcttat acaagccaaa tcggcagtgt atggatgtat 3820441 gtcctggggc tcttaggact gggcatcacc cttgcacttc tgatgcttaa acgcagccat 3820501 ccgttcagta agctgctgac catcatcagc ttgtgcgttc tgcttctcac accagtttac 3820561 tggtcagcaa cgccgcttct atacggtggc aacagcgtcc ttcctgaatc cggcccgcag 3820621 ctcaaaggct cagcaaacgg cgggaacatg ttctcttcag aggtcgacag cgggctcctg 3820681 tcctatctga gaaaacacaa taccggcgaa gagtatttat ttgctacttt gacaaccgta 3820741 acagctgcgc catacatcat ttacgaaaat gaatctgtta tggcaatggg cgggtttaac 3820801 ggcacggatc ccattctgac tgtgtcggaa ctgaaaaaac tgatcaaaga aggcaaagtg 3820861 aaatacttcc ttctgtcaga aaacaactca ggcaacagcg aacttgtttc ctggattaag 3820921 aaaaacggaa aagaaataac atctgacgag tacagcggtt cctccagcag cacaaacagc 3820981 gtgcagggaa tgcgaagagg acctggcgga gaaagccagc aaactcttta tctcgtggaa 3821041 taaaaaaaga ggcttggatg aatccaagcc tcttttctat taagcttctt cttttacatg 3821101 tacctttaac acagcctgca cttcaggatg cagcttcaca ggcacgtttg tatatcctaa 3821161 tgcacgaatg ccgtccggca gttcaagctt ccgcttatct actttaatgt tatggtcttt 3821221 ttggagctgt tcagtgattt gcttgcttgt cactgaacca aataaacggc cgccctcacc 3821281 tgattttgcg ctaagctcaa cagtcagttt ttctaatgtc tctttcaagc tcttagcctg 3821341 ctcaagctca gcaatggctt cttttttctc tttctgcttt tgtccgttta acgcgctgat 3821401 gtttgacgcg ttcgcttcaa ccgcgaggcc ttttttaatt agaaagttat gcgcataacc 3821461 gtctgctacg tttttgactt cgcctttttt tccttttcct tttacatctt gtaagaaaat 3821521 aaccttcatc tctgtacgcc tccctcaaaa tactcatcta tggcgtgctt cagccgttcc 3821581 agcgcttcag aaactgaaat gccggacaac tgagtcgccg catttgttaa atgccctccg 3821641 ccttccaggg cctccatgat gatctgaaca tttacctcgc caagcgaccg agcactgata 3821701 caaaccgttt gttcatcccg tctcgccacc gcaaatgaag cctcaacctc actcatcgat 3821761 agcagcgaat cggcagcctg cgcaatcagc acttgatcga agtattcctc ttcattttca 3821821 ggaagagaag caatcgcaat gttatcttta tagaggaccg tatgctggat cagcttcgcc 3821881 cgtttaatat aggaatcaac ggtttctttc agaaacttct gcaccagcac cgtgtcggcg 3821941 ccttttgccc ttaaataaga agccgcatcg aaagtccgcg agcccgtgcg gagagaaaag 3822001 ctctttgtat ccactattat accagctaat agggctgttg cttcaatcat attgattttt 3822061 aagcgcttcg gctgatattc aagcagctct gtcaccaatt ccgctgtgga agaagcgtat 3822121 ggttccatat aaacgagcag cggatctctg ataaactcct cacctcttcg gtgatggtcg 3822181 atgaccacga tatgttcaat tttattgacc agccgttcct ccatgacgag tgacggctta 3822241 tgtgtatcaa cgatcacaag cagtgtgtca tcattggaaa tctccattgc ttcttcaggc 3822301 gtaataaatc ttgaccacag ttcttcatat tttttgattt ccccaatcaa acgctgcaca 3822361 cttgatccga tttggtttgg gtcaatcacg ataaaaccat ctttgttatt tgcctgagcc 3822421 acctttaaaa tcccgatcgc tgcgccgata gaatccatgt cggggaattt atgccccatg 3822481 ataatcacat tgctgctttc ggtgacgatt tcctttaagg cgtgagaaat cacgcgggcc 3822541 cgcacccttg ttcgtttctc cattgggttt gttttaccgc cgtaaaactt caccttgccg 3822601 tttggcagct taatggctac ctggtctccg ccgcgtccca gtgctaagtc caagctggat 3822661 tgcgccaaat cgccaagttc tttcagggaa gagactgaag ccccgacacc gacgcttaac 3822721 gtcagcgcta caccgtcaaa cgaggttttt tcccgcactt catcaagaat cgaaaacttc 3822781 gaattttcga gttcagttaa gatatgttca ttaagtacag caataaagcg ttctgaagac 3822841 gtccttttca agaagatccc gtactcctgc gcccaagcgt tcagcaaaga tgtcacctgg 3822901 ctgttcatcg tgcttctcgt ctggtcatcc aatccttgtg tcacatcatc atagttatca 3822961 aggaaaatat atgccaggac ggttctttcg ttttcatata gcttttcaat ctggatttgt 3823021 tctgttacat caaagaaata taagagacgc tcatcccgtt tgatgacaac cctaaacttg 3823081 cggtcattca atgtaaccgt ttccgattcc acctcttgtt tgataagcgg cactaccgat 3823141 tcacaagtat cgtaaagtga tctccccact aaagtgcttt cattaaaaca agaggaaaga 3823201 aacggatttg cccattctat ataatattgg tcattaaaaa gcatgattcc aatcggcatt 3823261 tccatcaatg cctcttcacc gacttttttc aacctgtagg acaacgtaga aatataagca 3823321 tcaatctctt gtcgaataag agaatcagca cgcttaataa aaaacaaaat aactgccagc 3823381 agcagcactt cgacggttcc taatatccag ttaaaataaa agctgatgag gattgtaata 3823441 attgacagag caatcaatgc atagatggga taccgaaaca gcggtttttc ataaaagctt 3823501 ggcatttcta tcactcccca ccatgtgagt aaaactcatg ttcacttcac cttattcctt 3823561 atatgaaagc ccatatctaa aacgcctaaa atgcgaatgg ccgccatgaa gaccggatgc 3823621 acaaacccaa gtatgacagc aatcacagcc gcagcctttg gatattgttt cttatggcaa 3823681 tagaaaaaga taaatgataa accttggatg aaaatcagaa acccgagtat aaactcccca 3823741 tttaaagcga tagagtacag catttggcct ttttctaaag gcaaaaatga aagcatgaca 3823801 ataatcaaat acagtactac aacactttgc ggaaacttca actctctaaa aggctttaga 3823861 ttaggaatat cgggggagaa tcgccttaag agcggcttag cgataaggta actgaggaaa 3823921 gaaaaaataa ctcctaccat cacaatagct gttggaaaaa gatattgaac gatacccaat 3823981 tgttcttcca tcagttttaa ttgcttctca aactgcccag cattgcccga ctgcttcgct 3824041 acagtttcta caatatcaag agattgccgg tattgtgtca ttgcctcatc aatgatattg 3824101 atacccaaaa actgaatgct tatcacaaaa tagaagacaa tactaagcat ataaataaga 3824161 gcgcccgaaa taatggcgtg cccgggctct ttccttttga aaaaatgtcc catggcaatg 3824221 ccggcgcaag ctgacataaa agctacaata agcccgttaa aggacccgac aataaaaaca 3824281 accggaagac tgacagcgcc catccatatc cctagcttca atccatgtct gatcgtatac 3824341 aagatcattg gcagcggcag tgcaaataac agaattgttc caatcacagg aacataaacg 3824401 accagaagcg taatgatcgc aaacagactg attaaaatag caccttccat taaagctctc 3824461 gtttgtttca cttagtcacc tcgtatcatc ctgaacatac gaatagaaaa gagcagcata 3824521 aacgactgct cttttgttca tcgctgcaac atgctttgca ccgaatgttt ttatatcatc 3824581 tctaaatttt acttttatat tttaacataa gtccaaatcg caagtaaaat gacgctaatg 3824641 tttcatgtga aacatgaaaa aggaaaagac attctttgaa aagaatgccc atcacaatta 3824701 atgtttatca tccataaagc cagaagattc cttgtttttc tttttcgttt ttctgacata 3824761 cataaaaatt aagatcacca gtaaaagggt tgttgcttgc agaacgccgc tgctaaacaa 3824821 gaaaaagttc tttatcatgt cccacattgt gtttcacctc tttgtgcatg ttctcaaccc 3824881 gtatcctata taaggtgaat ttcccttttt aaaaacttca aaacatcatg aacaacattg 3824941 agcgttgggc atatgctgat atggaatctg atcgataaag gagaattttc acatggatga 3825001 acgcagaaca ttggcttggc atgaaacatt agaaatgcac gagctggttg cttttcaatc 3825061 aaacggactc attaaactga agaaaatgat aagagaagta aaagaccctc agctcagaca 3825121 gctttataac gtgtctattc agggtgttga gcaaaatttg agagagcttc ttccgttctt 3825181 tccacaggct ccgcacagag aggatgagga agaagaacgc gcagataacc cattttacag 3825241 cggtgacctg ctcggttttg ccaaaacatc tgtccgcagc tatgccatcg caattacaga 3825301 aacagcaaca cctcaattaa gaaacgtact ggtcaaacag ctgaatgctg ccatccagct 3825361 gcacgcccaa gtttatcgat acatgtatca gcatggatat tatccgtctt acaacctttc 3825421 tgaactgttg aaaaacgatg tcagaaacgc caacagagcc atttcaatga aataaaacaa 3825481 gcagcaaagg agttcccttt gctgctattt ctgctgatcc ttcactaagc cgttcgaacg 3825541 ataagattcc agcacgtctc tgttggattc tccccattct ttcatttgca aaacaatcgg 3825601 ttcaagcgtg cgcccaaatt ccgtcagaga gtactctacc ttgggcggca cctggtgata 3825661 aacctcacgg tgcacgatgc cgtccgcttc cagctccctc agctggagag taagcattct 3825721 ttgagtaata ctcgggcaga ttcgccgaaa ctcattaaat cgtttcttgc catctatcat 3825781 gtgataaaaa agaattcctt tccactttcc gccaatgaca tctagagtga attcaactgg 3825841 acagccttct ttgttcgggt atatattctt tttttcactc attcttgacc ctccaatagt 3825901 accttttttg atactacatt acattttgca actaatctac ccagtatttt acacaccttt 3825961 tctccttagc tcaaagaaaa tgcttcttat tcacatcaat ttttaagggt ttgcatgatt 3826021 acacctgcag caagacgtgt taaactatat aaagattaca ctacttaaaa aaggatagga 3826081 gctatcatgg aaaagatact tattttcgga caccaaaacc cagatacaga tacgatttgt 3826141 tctgcgattg cttatgctga tttgaaaaac aaactcggct tcaatgctga gcctgtccgc 3826201 ctcggacaag tcaacggcga aacacaatac gcgcttgact atttcaaaca agaaagcccg 3826261 cgtcttgttg aaacagctgc aaacgaagta aacggcgtta tcctggttga ccataacgaa 3826321 cgccagcaaa gcatcaaaga cattgaagag gttcaggttt tagaggttat cgaccatcac 3826381 cgcatcgcta actttgaaac agctgagccg ctttactatc gtgctgagcc tgtaggctgt 3826441 acggctacca tcttaaacaa aatgtacaaa gagaataacg tgaaaatcga gaaagaaatt 3826501 gccggcctta tgctgtctgc gatcatttct gattccctgt tatttaaatc tccaacttgc 3826561 acggaccaag acgtagcagc agcaaaagag cttgcggaga tcgctggagt agatgctgaa 3826621 gaatacggct tgaacatgtt gaaagcaggc gctgatctaa gcaaaaaaac agtggaagag 3826681 ctcatttctc ttgatgcgaa agaatttaca ctcggcagca agaaagtcga aatcgcacaa 3826741 gtaaacacag tggacattga agatgtaaaa aaacgccaag ctgaattaga agctgtgatc 3826801 tcaaaagttg tggctgagaa gaatcttgat ctgttccttc tcgttatcac agatatctta 3826861 gaaaatgatt cacttgctct tgcaatcggt aacgaagcag cgaaagtgga aaaagcgttc 3826921 aacgttacat tagaaaacaa cacagccctc ttaaaaggcg ttgtttcccg taaaaaacaa 3826981 gtcgttcctg tcttaacaga cgcaatggct gaataagcaa aaagcatccc gcgtcgggat 3827041 gctttttctt attcacccag cttctcaatt tgtcccatca catcagtaat ttgctttgcg 3827101 ttttggacca ggtctgactg ctccaattct ttaagcgata ccttgccttc ctcggcttgt 3827161 ttcaacacat cttcagcgct tttctgcaag gtttcgttat gctcctgaat ggttcgatga 3827221 atctccgctg cggcatcagg cggcgttaat tcattaaaat cagcggcagc cttctgaatc 3827281 gactcaagct gcgcttcaag tttttctttc gcctcggtgt catttacagc tttctcagcc 3827341 aattcaggcg cttcctctgc aaatgtcttc accttctcca cataaccagc tgcttcactc 3827401 gtatagttca atccgtcgtt cacctgatca agcatgccgc atccgcctgc actcaaaagt 3827461 cccactccgg caagtactgt caaaatgatc ttcatcttca gccccctcat cgtttctttt 3827521 tcattttttc ttttaagatc ggaatcaatt tctctttcgc taacggcagc cctttcctca 3827581 ccaattcacg cttcagccac tttttcagct tagacattct gatgctcctc tccctttttg 3827641 ataaaaatga aaaaactcca ccaatttggt gaagttcctg aaacaaaaag accttcacca 3827701 aatcagattt ggcaaaggtc tcgctaacaa tgagattgcc agcaaagccg aggacacctt 3827761 gtcccgtaat gacgacttta ctgtgaaagc tactcccctt tggagtgttc atttttatta 3827821 ctttcattct aaagcaccga tctgttccag tcaaattcct gccgtttata taaaagcgcg 3827881 ctgtggtatt taaaatttga atggtttttc tatcaggaga tcatgctatg acagaggagg 3827941 ttttcatcat gagtcaagag cgcgtgaaac ggcctgggca taccagatgg tacatatctt 3828001 cgttacttag cggcattatt attcttaatt attttgaccg agtggccatc tcggtagcgg 3828061 cccctgcgat acaagattcg tttcacctta ctgcaactga actcggcatc gtgttttcca 3828121 tttacaccta ttcctataca ctgatgcagc tgcctgtcgg aagtttgctg gaccgttttg 3828181 gggtcgcatg ggtcacgagg gttggaatga caatatggag ctttttaacg atccttcttg 3828241 cttttttgca aggaaaattg ctgttgtatc tgttccggtt tctcattggg ctgacgagcg 3828301 cctctgcgtt ccctgctgcc tctaaagcaa ccgctctctg gtttcctcca agtgagcggg 3828361 gattggcaaa ctcactgttc gattcggccg ccaagttttc aaatgtaatc ggcgcgccat 3828421 tggtcgcctt tcttgtcaca acatttgact ggcgtgtcgc ttttttgacg attggatgca 3828481 tcaatgtgct gtttacgatc tttttctggc agtattatga acagcctgaa cggcacaaac 3828541 gcatttctaa aagtgaacta aactatattc aaaaacacaa tgccattaca acagagcaaa 3828601 tcccttacaa aacgggcccg cttttaaaaa agcttttcac caatcgaaaa gtatggggct 3828661 taatgatcgg atttacaggg tacgggtata cattcaacct gctgctcacc tggcttccga 3828721 ctttctttaa acatacatac ggtatggatc tcatgtcgtc cggtttattt acggcagtgc 3828781 cgtggctgat ctcaaccatt tccggaattg ccgtcggcgg ctggctcgtc gattatttta 3828841 ttaagaaagg ctatcctaat accaaggtgt accgaaccgt aatcatagtc ggaatgagct 3828901 ttggcttttt ctttttagga tccattctga cgaacaatat taccgtagcc attatttgca 3828961 tttccatcgg actcgccgga atttccgcaa ccgctccggt cggctggtcc atctccgcag 3829021 aactcgcgcc gatcggttcc gtatccatgc tgagctccat ggtgaatctc gcaaacaacc 3829081 tgttcggagg cattattgct gcgtcactga cagggtattt gtttgatgtg acaggctcct 3829141 ttaccctcag ctttctggta gctggttttg tgctgttgct gggattggtt ttttatgtgt 3829201 ttgtattagg ggatgtaaaa cgaattaaac tatagaacat gaaaaagaga gctgccagtt 3829261 ggcagctctc cctttacatc aaagaatcgg cccgtcccca tttaccttct cctcgtcctg 3829321 ttcctctata tcaagccccg aagctagcat ttcctgctct atctgttcga gcacctgctc 3829381 gttttttcct tgaagaccac cttcataatg aaaagcatcc tgtgtgccgt tttcctctat 3829441 tgtcgctaaa atatcgtgga tatcattatg gtctcctgaa atggagccga atccctggtt 3829501 ttgtttttta taattcacaa aaccgctggg gaggttgttt ccgaggttta cacatgatgc 3829561 gctccgagta gtaattcatc agtgtatcaa aatcttcatt ttggattgcc acatcacatg 3829621 cagagatgat gtctttcaat tgctgttcca aatgaattcc cctaatcatc atgattggat 3829681 atattataca atgtttgaca cgtagggatc cttttcattt ttgtttttac ggtttcgctg 3829741 gtccatttcc gcagagctgg cgccgatcgg ttccgtatcc atgctgagct ccatggtaaa 3829801 tctggcaaac aacctgttcg aaggcattat tgcggcttca ttgacggggt attttgtttg 3829861 atgtgacaag gctcctttac gctcagcttt ctggtagcca gttttgttct gctgcttgga 3829921 ttggtttttt acgtgtttgt cttaggggat gtaaaacgaa ttaagcggga ataaagagtg 3829981 cttgtagaga aaacgttgtt ctttctacaa gctttttagt tttgtgctgt ttttcaagat 3830041 attcagctgt cataaaaaga aaatgagctc ccacataccg gctaggtatg tggcgttctt 3830101 cttcatgttc tggcatgcag ctgtgaggag gatttgtttg ctcaccccct gaacctgcga 3830161 tagctaagcc cgtgcagttg ttttgaacct acaaagcttc gttctatttt ttcttttctt 3830221 tttttagaga tttcctgaaa tagaaaagca atcttttcta accttttctt tatggttttg 3830281 ccatacatac cgagtaacga ctttctggcg tttcgttgat tttgtgtaat attctcaaac 3830341 atatttcagg atttgattta tatgaccgat agtctttgcg atcaattgtt gagtacgtaa 3830401 gtgtatgctg attcaacaaa tgtatctgta ttgttcactt tataatgaaa tttccatttt 3830461 ggaagcaaac ccctgactgg gtgataacgt ctatgtgcga tggcaccaaa aacttggagg 3830521 tcaaatagtc ctttagagat gagagttgtt aagtagccgg aatctagagc gacggcttct 3830581 acttgaaaat caaatcatgc aatttagtga tccaatcggt caaggtaggg cttggaacag 3830641 aatcatggac ttttctggag ttgcaaacta ttaatcgtcc tcattaaatt tataataaaa 3830701 atattctcaa ttgagcaaat cgcccaccct ttttccttta taacataaaa tccaatacta 3830761 tcaataaaat tctttacagg ttattacagt taagatataa tatagttaat cttttacgta 3830821 aaaggaggtt tttattactt gtgttgaagt tttaaatagg agtaactcca tctccccatt 3830881 acggtcttca tttaatttca tcctgagttt tatttagtta gatataaaaa cgaaaatttc 3830941 acattatttt taactaaccg atagtataaa atatatattg aaaggattgt aaaattatga 3831001 ataaattcct gaagagcaat ttccgtttcc ttcttgcggc tgctttaggc atatcattac 3831061 ttgctagtag taattttata aaagccagca atgataacta taaattccat ttacttgtac 3831121 cttatggcta tggtaatgcc tattcaaatg atgcatttag acagaccact catacagata 3831181 atccttggaa agtaaattta cagaaatcgg cagaaggtaa aggtacaatc atgacatttt 3831241 ggttgattaa cacagggaat agtaaaattc caaaagcttc taaaatacat aacgtaaaac 3831301 aaggaagcgg agctcattat tatcatgcaa atagccaggg aagccataca tatgtagcct 3831361 tagcagttga aaacaacaat tacagtgcaa gttcttatgg tatagatggt gtatgggatg 3831421 aagaaacttg gtaaacaaga accttctaaa aacgttggca ccttttagcc acgcgaaaaa 3831481 atttagaatg ataatctttt tataagatta tcatttttat ttattctatt aagaattgag 3831541 tgagaacatg gaaagtcata tttatcgcat tatcaaaaat aaattaacta taataatatt 3831601 tactataatc atattaattc cttgtgttga tatatcacta ttgttaatga ctaacacaga 3831661 ataccatcct gcatatgcgt ttttcctttc tggcacttcc gtagggcatg cttcacaaat 3831721 gatcctatta tggtttcttc cgctttattt tttgttacta tgtgctgacg attctataca 3831781 agattataaa acaggatatc attacattct tataagcaaa gttggcagaa aaaaatattg 3831841 tttggaaaaa atatttacct cttttatcat ttcatttttg acaatgtttt tgtcactaat 3831901 attaaacttt ttattggttc aggttttctt ttttaaaggt acatttaaaa atgacttaga 3831961 ccaaattaaa ttccctgata acagccttta tacttttagt atggcccatc cttatatagc 3832021 aattgtgtta ttttctatta tttgttgtat tatgtctgga tttgttggag cacttggttc 3832081 aagcctcagt ttactttttc gtgataagaa gtatgcctac ccagcaagtt tttttatttg 3832141 gttcgtactt atactaaaaa acaaatcatt aatgttttta ttccaaccgt ttacagaata 3832201 cggttataat gtacttctcc ctatcctatg tttgtctatc tttatttttc taataataat 3832261 ttctagtatt gttttatatg aggcaaaata caatgaaaat taaaagacta ctattaattt 3832321 tatgtttact actattttta gttactttat ggttcaacca gaaccacact tatcttggaa 3832381 agaattctat cgcgtcatta ctatatatga ataatagtac attcggatat agttcaatat 3832441 ttgcatatac cttgttttat attgtcccgt ttcttatgtt acttagtaac ttttttcatt 3832501 cagaaaaccc ctacaaagta atgaggatgg ttaagcgtaa aaattactac aagtctaaaa 3832561 ttatggagat tgggtttgtt tctttacttt tttcttcaat acatactgtt attaatatta 3832621 cgtgtacaca tattttcttt agtaaaaact tgttggtcga agcaaacttt ttatcaattt 3832681 gtttattaaa catgattagt ttagtgtttt tctacttatc agtaggtatt atgtttagac 3832741 ttacatacga tctgtttaat tcagtagcat tagcaatttt tattgtgtat ataattttag 3832801 atagcttgta tttcggcgtt aaattattac ttcctaatgg atattgggaa ccctttagag 3832861 acttggctat attcacaaat atgctcaata gatattggtc aacttcaaat cttataatag 3832921 tttatattag acagataata atagttttta ttttttattt agttggatct tcaatttttt 3832981 tgaataagga ttataaaaaa tgaggattaa aggctttttc ataactttag ttgcgataat 3833041 atttcaggcg tcattatcga gttataataa taataaaaat gtctttcctt ttttagatgg 3833101 cataccaata agcacctcgg gtcattatga gtatcaaaat attttattgt ggtttgtacc 3833161 tattgtttcc ctaagttttt gtttctctgg gagtattaga gatacataca tttcgtatga 3833221 gcaattaaag ttagtaagag aacatagtag agttaaatgg gtaacatctc aattcttaat 3833281 aattacagtt gtacttttaa tctttacttt atctcagatt gctatatttt atatttattc 3833341 acttgtatct cttcataacc ttgatattaa ttccgttatc aataaaagat ttgttatgat 3833401 gacactcatg tattatctaa ccttacttaa cttatttagt tttcaattat ttatggagct 3833461 ttattataaa tctcaaatag cacaattaaa tataagcgtt tatattattt tttcgttaat 3833521 tttagcaaag aagttagtgc aattaaattc tccgaaagtt attcactact ttttaattcc 3833581 aaactacagt aatggattaa gaactgggtt aagctattat tcccaatctg gaactgctat 3833641 tattgaacca ttattaggtt tgtttattat aatcatttta cagatttcaa tagttatatt 3833701 atctgtctta aagttcaaaa aaatagatat gctaaaaagt gagggcttac aatgattgag 3833761 gtattaaacc taacaaaaaa attaaaaaga ctacagtttt agataatatc tcttatacat 3833821 ttgaaaaagg aacaatttat ggactatttg ggagtaatgg ttctggaaag accatgctac 3833881 ttcgtgcatt atccgggtta atagtcccta ctgaagggag tataactatt aaaggtgaac 3833941 aattacataa agatatctct tttcctaaaa gtgtaggatt aattatagaa aatatgcagt 3834001 tacttcctca gtatgatgct tttactaacc ttaaaatttt gtcaaaaatt aaaaagatcg 3834061 catcagataa tgatatatta gattctatta gtagagttgg tttggaaaat tttaatagtg 3834121 taaaggttag taaattctcg ttaggaatga aacaacgatt aaatattgca caggctattt 3834181 ttgaaaaacc tgatatattg ctacttgatg aaccaacaaa tgcgattgat gaaaaaggag 3834241 ttgcatttgt tcatgacatt cttttacaag agaaaaaaag gggagctacc attattatta 3834301 ctagtcatca caaggaagat attatatctt tatgtgacat tgcattagaa atgaatcatg 3834361 gacgtctaga aacttcagaa aaagtaatat ataagaaaga tagttagttt aaactggcta 3834421 tttcttatcc aatgatagac tgcagacaag ttcaactgct gtaatgctag aaaatccaat 3834481 gaaatgctga taattgcgaa gagatatgat cagtcagaaa acaaatctta aaaagaaaaa 3834541 gtaaattcat caatatttct aataaacctg gcaaacaacc tgttcggagg cattatagct 3834601 acttcactga cgggatattt atttgatgtg acaggctcct tacgctcagc tttctggtgc 3834661 cggttttgtg ttgttgctgg gattggtttt ttatgtgttt gtattagggg atgtaaaacg 3834721 aattaaactg gaataaagag tgcttgctga aaagcactct ttttctgcat cgaaagaata 3834781 cttaagataa gtcactccca aaaatcgtaa cagtctgacg gttaaacata aacctctgcc 3834841 cgttccattt taatacggtt tgaacatatc ccaatgagtc ggcgttatac cttcccgcta 3834901 tccgctggta cgccaataat tcgtatacgc cgtctctgtc aaaatcaacc ggatacaagc 3834961 ccgataaagg attcacccat ccttctatcg gcatttttaa cacaccttgg ctgttataaa 3835021 tctcattcaa atattccctg cccttgtaag taaggtcgag gatatacgtt tcgttttgct 3835081 gatgactgat aacgctcgct ttatattgat tttgatacct cacactgtac tttaattcat 3835141 cattcaatac atctgaattg aaaattcgcc ggaactgcct gtttagatag gcaaacacat 3835201 atgcataaat agcaccgccg cttccccctg tgtccattac tactgccaca tcctcaatct 3835261 tgtcgcctgt catatccccc agaaaaagtg acggattgta tcccatattg ttttgaagct 3835321 gaatccgctg ctcctgatgg gttctgccat cacggatcac caatgtgata tttctccata 3835381 acgggctgcc gggcatttga tttccagtta gaaagacctc gtcaataacg ccgtctcccg 3835441 ttacatcgcc gcgggtagat acaatgattg cacgtgagga gacaggctgc cgaaatacgt 3835501 atggatgttg aacaagtcct ctgccttcat aaaaccaata aggagccatt ctgatgtcat 3835561 acacattcaa ttgtgtcacc ttccctaatc agctgaatga atcattatat gcaggaatgg 3835621 cacatcaaag acatatctta cacaccaatt aaatccgtac catatgaatt atcaattaca 3835681 caaagccact cgccttgcgc attcttttta aatacatagg tcgcccttct ttccatcgca 3835741 tactcggagt cctttttatc cgaatcaagc agtgtctgag aaagaacgag taccgtgtca 3835801 cctgcttcca acaggatcat tttcccttgt gtcgggacaa tatgatgatt gaaatagttc 3835861 gcaatcgtga taaacgcttt tttgatttct tccttgcctc gcgcgatcat gcccggcttc 3835921 acaactaaaa cggcatcttc cgaataataa ttcatcagtg tatcaaaatc ttcattttgg 3835981 attgccaaat cacacgcaga gatgatgtct ttcaattgct gttccaaatg aattccccca 3836041 atcatcatga ttggatatat tatacatcgc tagaccactg aaaccttgaa aacaaaatga 3836101 aaagtatcct tttttcctat ataatcaaat agatatattt aacaaagtac ccaagtgaag 3836161 gggtgaacat tattgtctgc ggaagtaacg ttacatgaca atatacatta tgatttaagt 3836221 gcggattgcc agcactgttt tggcctgtgc tgtgtcgcct tgccttatgc gaagtcggca 3836281 gattttgctt ttgataaaga cgggggcacg ccttgccgca acttacaatc aaactatcaa 3836341 tgttctatac ataaagatct cagagaaaaa ggatttcgag gctgctctgc atatgaatgc 3836401 tttggcgccg gccaaaaagt atcccaaatc acttatgagg gaaaggattg gcgaaacagc 3836461 cccgaaacgg ccaaccagat gtttgacgtt tttcctatca tgcagcagct gcacgaaatg 3836521 ctctggtatt tacatgaagc tctttctata gatatagcca agccgattca ttctgaactg 3836581 agaaccactt tcgaaaaaat agaaaggctc accagactca gcaaagaacg cttgctgaca 3836641 ctgcaggtgg acgagcatcg agctgaggtc aatgaatggc tgttaaaaac aagtgaactg 3836701 gtgcgtgccc aagcccgcca tccaaaactc ccgaaaaagg tcagccgggg aagtgtcctg 3836761 atcggcgcga aactgaaagg gcttgatctg cgaggagcaa atctaagagg ggcgctgctc 3836821 atagccgccg atctgagaaa tgccgatttg agaatgacag actttatcgg tgcagatatg 3836881 agagacgctg atctcagcgg cgccgacctg accgggagca tctttttgac acaggcacag 3836941 gtgaacgccg ccaacggcga ttcgaataca aagctgccgc tgtctgtacg aacccctgcc 3837001 cattggaaat aaaaaaggac ccgctaacgg tcctttttta ctgatcaatt caatcctttt 3837061 tcgttcctct tatccggcat tttcacactt cttgccaagt atcccgacag ccataacgca 3837121 accagcagca tgaaggtgat cataccgacg acgcccagcc agtgaaaacc agaccagaat 3837181 agccctccga ttgttccgaa aacacttgaa ccggcgtaat aaaagaacaa atacagcgat 3837241 gaagcctgtg ctttgttgtg aagggctctc ctgcccaccc agctgctggc aactgaatgc 3837301 cctccgaaaa aaccgaatgt aaagagggca atccccagaa ttttcactgc cagcatattg 3837361 tttatcgtaa ataacgcacc tgcaatgacg atgaaaatat tcatcaccaa tattttcgga 3837421 tagccatacc gatcaaccat tcttccaatg aaagacgagc tgaaaatgcc tacaatcatc 3837481 acaataaaga tccagctgga aaatgcttta ttaagcgaat acggcgggcc caacagcaca 3837541 tacacaatgt aattaaacaa ggcaacattg cttccaagca gcaaaaaacc aatgagaaac 3837601 aagctgaata gtttacggtc cctcaagtgg ccgatcagag acattcccaa tttcccgagc 3837661 ttcaattttc ttggcgtaaa atgcctggat ggcggcaaat ttataaaaaa tataacacta 3837721 gcaatcaaac taatgacacc aattgtcccc atcgccatat gccaattcaa gtactcgctc 3837781 aggagcccgg aaacgatcct tccgaaaacg gcgccgattg catttccgct gatatatagc 3837841 cccatcgctg atccaagact tccgggttca atttcttccc caagataagc catcgcaatc 3837901 gacggaaggc ctgcgagcgc aacgccttga atggttctca atacgagcag tgtatgaaag 3837961 ctcggactaa aggccgatgc cagacagaga accgatgcgg ccagcatgga aatacccata 3838021 ataggcttgc gtccccacac ctcggataat gaaccaaaga caagcatgct cacagctaac 3838081 agcattgtgg taacagataa agaaagactc gccgcagtag gcgttacatg aaattcccgc 3838141 gtgaattcct ccatgagcgg ctgtacgcaa tatagaatcg caaatgtatt gaaacccgca 3838201 gcgaagaaag caaacgtaat ttttcgaaaa accggtgtgc cttttcgaat gtatgtcatc 3838261 gggactttat cggtccctca tcatgttgtg gagcactgcc attcataaac aatcatcctt 3838321 tatttcttac gaattcaaac atcctcgagt ctgtttatat tattatctta gcaccgttga 3838381 tatatgttgt ataatgcata taaaatatcc ttttcatgct tatatgtaat aaggagagat 3838441 gataattgga atgggaacaa cttgaatatt ttcaaacact ggcccggatg cagcacgtca 3838501 cgaaagccgc aaaaagcctc tccatcacac agcctgcact ttcacgctct atcgccaggc 3838561 tggaaaatca tttgggcgtc ccgctatttg acaggcaagg acgatccatc agcttaaatc 3838621 aatacggaca cattttttta cgacgggttc aggcgatgat gaaggagtat accgaaggaa 3838681 aagaagaaat ccaagcctta ttaaagccag accaaggcgt agtctctctc ggttttttac 3838741 atacattagg caccacgctc gtgcccgatc tcatcggctc ctttcagcag gaatacccca 3838801 acatttcctt ccagctgaag caaaaccact cttattggct gcttgaacga ttaaaatccg 3838861 gagatctgga cctctgtctc ctcgcttcga ttaagcctga aaatccgatc caatggatca 3838921 agctgtggag tgaagaactc tttgtatttg tgccaaatga tcacccatta gccagtcgcg 3838981 aaagcattac cctgaatgag attgccgggg agcgttttat tttattgaaa aagggctatg 3839041 cgcttcggat gacggtcgat gagctgtttg agaaggccaa tatacagccg aacattatgt 3839101 ttgaaggaga agaagcaact actgccgcag gttttgtggc agccggtctg ggcatatcta 3839161 ttctcccaga cctgaaaggc ttagaccaaa gcaaaatcac caaaatccgc gtcagctggc 3839221 cggaatgtca gcgtgtcata ggaattgcct ggataaaagg caggttttta tcaccggttg 3839281 ctgagacctt taaacaatat gtgatcagcc atttttctga gtaggaagga ttcaagcatg 3839341 aatgtcaaaa aaatcacgtc agaacaggat ttacatacag cgtttgaaat cagaaaggca 3839401 gtatttgtag aggaacaagg ctgtcccatt tcggatgaat tcgatgagtt cgatacactc 3839461 cacggtgact gccagcacat cctggcttat catcagaatg tacctgttgg cactgcacgt 3839521 gtccgtatcg ttggccacac ggggaaactg gaacgaatct gcattctgaa gtcttaccgc 3839581 aaattcggtt tgggaaaagt gatcgtcgat gcattagaac gtattgtaaa agaacaaggc 3839641 atttctgcct tcaaactgca cggccagaca caggcggcag gcttttatga aaagctcggc 3839701 tatcggactg catcagaaga atttatgctg gacggcattc cgcatgtgct gatgacaaaa 3839761 caagacgatt ctgcgctata gattgttcac aaatttgtca cttatgagca tgaacggttc 3839821 attggtatac taatcaccga ttatggagag aaggaatgat tgtatgccag caaataaaaa 3839881 agaaggcctt atatttggcg tgatgatgtg ctttggaatg gtttgcgtca tgtcgattta 3839941 caatgccatc atcaaccgag ccatctacga tttttcactg atgaccgttt ttgaaatggt 3840001 catcggtttt atgatcgccc tcctgttaga tttactgtta gtgggccccc tcgccaagaa 3840061 gattgcattc cgcatgccgt tcgacaagac taaaaaaatt tatgtcatcc ttgccatgtc 3840121 aacttgtatg gtgattggca tggtactttg tatgtctgtg ttcggtttag tgacagcggt 3840181 tctagcaaat gggctgaacg gggacagcct cttcagtgct tatcttatga ttgtgttgaa 3840241 aaatttcatc ctggcctatc cgttgcaatt actgattatg ggcccattag tcagaggagt 3840301 tttcatgaaa tttgtaaaac caaagctcac agccgcaatt taaatagaaa aggagtgagc 3840361 ctgacactca ctccttttgc tcatgaatcg aatgtaaaac aagctccgca aaagcctctg 3840421 cggcaggcag ctgccatttt ttctttttgg gtgtgagtaa atcggatcga gggcttcacc 3840481 atgctggaga tttttcagct tatgtttttc acttccatta atccctatac cttaccacat 3840541 agtttttata caattcttcg ttataaagga tttcttcgcc atgtgaagag caaatgagcg 3840601 ttggtttgat ttgatctatg attgagccgc tgtcgatgtt ctcatttata tcaacactga 3840661 atcttcttat aggtgggtgt aaatcctcct tacttgtgat aaaaaggtcg cccgtcaata 3840721 gcgtacgatc gattttatga taatacacaa catgccccgg cgaatggcca ggtgttaaat 3840781 agtatttcag aggcagatga gcaagcgttt gctccgtcag cggctgtaca atatgggcta 3840841 cccctgtgtt ctccacttca tttttgttcg gatatggctc ttccccattg atgtacttta 3840901 gttctttctg gtgcgcaaaa atcggaatat caaatctctc taaccatttt gatgcacccc 3840961 cgatatgatc actgtggcca tgggtaagca aaatggcttt tggattgccg atcgctaacg 3841021 ctgccctaat ttgagcatca gcaaaacgtt ctattcccgt atcaacaata taaacatcat 3841081 caccatcttt gataaaccag gtatgaaccg gaatacgaag aggcacatca agctcaaatt 3841141 cacattgaaa gacatgttct gatagttgtc tcaaattcac gcaaaccatc tcctgtggaa 3841201 attttttgat agttttaaag aaaacagaag tgaacggact attttcaccc acgctcgagc 3841261 tgactggatt cttgagagga aacgccgatt ttcgccagca tcagctcaac ttgttaacgt 3841321 tgtccattaa taatcccttt tgttcccctt cttcacatat tcccaatcac gttctatatt 3841381 cttcctcact ctatgaagga gtgcagaaat ggtttccttt tcctctgaag taaaaccgga 3841441 caaggccact tccgtggaat gttctccttc tcttcttaac aatggatata cctttttccc 3841501 tttctcagtc gggaacagtt tttttatttt tttattttgc tcatccggca gtttttgaat 3841561 aaatccctgc atttccagct tcttaatggc ccgcgcggcc gttgtccggt ccacttttat 3841621 catttccgcc aatttttctt gaataattcc cggattttcg tatatacgca cgagatagag 3841681 atactgccct cttgttaagt ctaaatcttt aaattcgatg ttgcttatgg aatccaacgc 3841741 tcttgctatc atgccgatct cacgcaaaat atcattcatt cctaaaaccc ctcacgtatt 3841801 tttgttgcaa ttacaacaaa aatgttttaa ccttactatt ataagaccac atgcgtgctg 3841861 tacagtccag actaatatca gaaaaggatt gattcataat gaatataaaa agaataacaa 3841921 ctgaagctga tttacatgaa gctttaaaga ttagaagagg cgttttcatt gaggagcaac 3841981 atgtgtctga agccgatgag ttcgatgaat ttgatacgct tcaggaacaa tgccagcata 3842041 tcttggtata tcatgagaat cagcctgtcg gcaccggacg cgcgcgcatc gttggccata 3842101 cagcaaagct ggaaagaatc tgcatcctaa aaccttaccg taagtacgga ttggggaaga 3842161 tcatcgtaag cgggttagag gaaatcatga aagaaaaagg actgacttca tataagctgc 3842221 atggtcaaac acaagcggca ggcttttatc aaaaactggg ctaccagatt tcttcacagg 3842281 aatttatgga ggacggcatc cctcacgtct tgatgacaaa agaaatatcg cggaatataa 3842341 catgaaatat atgtattacg gaataggcat actcatatta agtttgggca tttccttaac 3842401 catacaatca ggactgggca catcaccctt cgatgccctt ttggttggtc tgtcaaaaaa 3842461 aatcggtctt accgtaggaa gctgggaggt ccttatttct gtgatcctct taatctgcaa 3842521 cgctatatta acgagaaaaa aacctatttt gctgggcttg attacagcat tcattactgg 3842581 aataggcatt gacctatggt tgtttgttgt aaaaaacacc atctatctaa actcgttgtt 3842641 aagcaaactg atttgttttg gaattggttt ggtgctcatc ggtcttggaa cagccatcta 3842701 tcttcagacg aaattcgcat caacaccgat cgatcattta acacttatta tccgagatct 3842761 ctccaaaaga acaatattgt tttcaaggac attggtatac gctcttttct tagtattagc 3842821 catcatcttt aaaggcccta tcggcatcgg aactctttta acggtttgtt tgggaggaat 3842881 gctccttcac gtttttatgc ctattgtgga aagacatttc ttatcaaaga atagaagagg 3842941 ttattaagaa acctcttctc gatccaaaaa acgaaacgca aaacaagccc cgtttcgttg 3843001 tcaattcttt atctctggta ctgttgaggt tttataatca attaaaattt atagtaccaa 3843061 aaaatcgcaa tttcatttgc tgttggaaag ttggaataaa gcatcgtatc aaccgcacct 3843121 attataaagt gatgtttggc ataaaaatga caagctgaaa tattaatatc ttgggtttca 3843181 agcataagac cacaaaaatg attctccttt gcccactcaa tcgctttatg taataatgct 3843241 gttccaacac ctttttttct atagtctttt gccacggcaa tgtcctctat tagtgcatac 3843301 ccattccagt tagaacggat cttaatccgg ccaatgcagt tgttttcaag ataatataaa 3843361 aaagccgctt tcccctcttc ttcaacataa ctaacatcca tgtcatcatc ttcatattgt 3843421 ttaaaataag gtttagaaaa tcgttcctca gtatatgtcc aaacaccgtt ttcaaaagca 3843481 ggtatcattc tcccaaaaac aacgaaaggt tcgtttggtt tattgaaatc tttcatattc 3843541 aaatgagtca ttttcatgat catatcaatc tccgccaatc gagataatat ttagtaaact 3843601 cgtttcgata ctattcaaca acagcttcca aaagtgtact ctttaagaga acagcattag 3843661 ataaggcatc cattacctta tatatttcac tatcttaatg aggtatttca acagaggctt 3843721 gtggtacagt aaaaaggaat agaaacaaga gaaaagaaga tgaacctatg cccactaaca 3843781 ataaactcaa tgagaaatat catacttcct tcaactcgcc cacaaccctg ttgactagta 3843841 tccgtggaga gaggaagctt tgacacagct tctgccattg atgacatctc tattgaagta 3843901 tccaaaggac aaccaaggat cgctctttga ctttttcaag aagaaagtag agtgaataaa 3843961 ggagtgattg agtatgttaa caagagaaga tatctttaaa cacgtcaaag aaaaatacgg 3844021 tacatcgcct gattacccgt gggagaaata cccaaactat gcttctttga gacatacatc 3844081 aaacaaaaaa tggtacggtc ttatcatgaa tgttctccca gaaaaattag gcttggatgg 3844141 tcatggcgaa atagatattc taaatctaaa atgtccccct gaaataagtg atcgcttaag 3844201 aaacggggaa aatatcttac ccggatatca tatggataag gaacattgga tttcaattgt 3844261 tttagaacgg acagatccag aaggcgaaat ctataactta atcgagcaga gctttcattt 3844321 aaccaagtga agataaagag tgttcctgct aatcaagctg cgaagagtag tgggcacttt 3844381 cattttagga tactgttctt cactctgtcc acaaacgcaa cttagttcat ctggtgcgag 3844441 agtgggagaa gaatttcaac caacttctta tgtaaaagga tgaatagtta tgacaaataa 3844501 cttaaaacag agaagaatca ttttagattt agcagttact ttagatggtt ttattgaagg 3844561 gaaaaatgga gaagttgatt ggtgtattat ggaccctgat atggggttta ctgatttttt 3844621 aaatcaaatt gatactattt tatatggtag aaaaagcttc gatttatggg gacaatacat 3844681 tccaaaaaat gaagaccctg atacagaaaa ggaactttgg aaattggttc atagtaaaaa 3844741 gaaatatgtt ttttccagaa cacaaaatga gattgataat caagccatat ttataaatga 3844801 taatattctt gaagaagtaa ataaattgaa gaaaaatcct ggtaaagaca tctggctata 3844861 tggtggagcg agtctcatta caacttttat aaatttgggg cttgttgatg aatttagatt 3844921 atctattcac cctgttgttt tgggagaagg aaaaccgttg tttattgatg taaaacagag 3844981 gataaattta aaaatggtga atacaagaac attttcctct ggcgttgtgc aaatcgttta 3845041 tcattggaat ggctaacatt gtaaagtaac actcgacagt aatccttctt attgaactaa 3845101 aggggaatcc ataaataatg ggttcccctt aatatactat ggaattatca atatcaaatt 3845161 ttctgtaata aaagaggatt gaaaaggacg atgtctcctc aattaacatc attaagcatt 3845221 atagtatatt ttcttctccc tcttttaagt aatcggctaa gttttgtatt tataaaaaaa 3845281 cgaaagaagg tgatccaatg cctactaaca ataaacccaa tagattaatc gctgagaaat 3845341 ctacttattt tacttcaaca tgctcataac cctgtggact ggttcccttg gggagaagaa 3845401 gcatatgaaa aagcgaaacg cgaaaacaag cctgttctcg tatctattgg gtatagctaa 3845461 cgatggctaa tctaaagaac atgctattga tgccatgttt attcatttta caaaaaagga 3845521 tcaaccttga attactttca caagattgat cctttcactc atttagccat gtctccgcga 3845581 acgtttatat acattcaaga ttactagcca acaaataaca atgattcctg caaaaagtat 3845641 gagcatattg ctatacaaat aggtagagtg atcaacgtca ataggcagca gcctatgatc 3845701 taggaagccg atagataata aaccgcctac aatcgcaata cccgttccct ctgataaaaa 3845761 gctcgtgaaa ttaagcaaac tcattccagc gcccgcttcc ttttctttca aactgctaga 3845821 cacaactgta gatataactg tttttgtgaa agatagcccc ccaaaaacaa aaattactat 3845881 aattgtcatg atccatggtg ctgcatctat aaaaaaggca gcgattaaaa agccggaaga 3845941 aagcaatgca cttccaatag ttagtacata caaggaacct ttccgatcaa caagcaatcc 3846001 cccaatgtaa ccaaagatga tgacactcat tgttccgggg aaaataatgc cgcttccaat 3846061 tgctgcagta cttaaatggt gaacatcttt catcatgtaa ggaaccatag agacaaatcc 3846121 tgctactgta ccaaatatta gtcctccgca aagggttcca atcacaaaaa agacgttttt 3846181 ccctaattca gggtcaacaa aagggtcctg agctttccta atgtgttgca caaatatgaa 3846241 gaaagcaagg atactgatga tcagaaaaga aaatctataa gatgttgtaa acagcataaa 3846301 aaatacgata cctgcagaca tcaatataat ccctgccata tcaatgtgtc ctcttattct 3846361 ctcttccttt ttcaacaatt ttataaggaa tggaacggtg ataattgttg cagttggaat 3846421 aagcagcaaa tacgaccaat ggatataatg agcaaccatt ccgccaatag ctggcccaac 3846481 accttctccc attgctacca gggacccgat caggccaaat gctttccccc tgttctcttt 3846541 tggaatatag cgcgcaacga caaccatcac aagagctggg aatgcggctg caccaattcc 3846601 ttgaataaat cgggctagaa tgagaatagg aaagaaagag tgtccaacaa atccaatgat 3846661 cgaccctaag ccatttacca taatcccaaa tagaagcaga tttttgatgc ccagctggtc 3846721 tgatagcttt ccatatagag ctgttccaat ggagaaggtt aacataaagg ctgtattcac 3846781 ccagtttgca cttgctggca gtttattaaa ctcgttggca atatcaggta atgagacgtt 3846841 cagaaccatt tcatttaata cgctgaaaaa tgatagaaca caaagccaaa tcaaaacttg 3846901 attgtgccgt aaagttgact gtgaataaga cgtattcaca atttcccctc cattaatgag 3846961 ggcagacgca gtttataggg tcattgatac gcttccctct tttaattgta ccctgttcat 3847021 tttattgcac ttcataataa ctccccctac atttgattga tatgatctta ttatatatag 3847081 actaaggatt aaacttttac tttttttata aaaatttgac cagattgcga aacaaggaaa 3847141 aacgttattc gcatttatct caagtggcaa aatgaaacat tagtttatat tttcacatca 3847201 caattatcga taagcagtca gttattgtat ttgtttagga taactgtggt aacctgaata 3847261 taaccaactt aggaagaagg tgatcccatg ccaaataaaa gtaaacccaa tagattaatc 3847321 gctgaaaagt ctccttattt actccaacac gcccacaacc ctgtggactg gttcccgtgg 3847381 ggagaagaag catttgcaaa agcaaaacgc gaaaacaagc cggttctggt cagcatcggt 3847441 tattcgacga cttgtcattg gtggcctggg ataatcaaat cgtgtggaac tccattaaaa 3847501 gataacagaa gccattttaa acgataatac tatttgttca aacaatacag tctacctttt 3847561 atttcattca ttttctaaaa cctgtaatcc gtaaccacgc ggtagcaggt ttttttattt 3847621 gcttgactta gagttaactc taaattgtaa actaacttta attaaatgag agggatgatg 3847681 ttgttgtatt ccattagtaa agctgctgag aagactagta ttagttcgta tacattaaga 3847741 tattacgaaa agattgggtt acttccacca ccaaaacgaa aaaacagtgg aaggcgtttt 3847801 tatacggaga ctgatattca gttcatgtta ttcctgaaaa gtttaaagga aacaggtatg 3847861 tctttggagg atattaatga gtttgtcaaa gacggatgca ttttggaaaa aatcaattcg 3847921 gatgttaaat cggcacaact ctccccatct ataaataaac gtattgagat tttaaccaag 3847981 cacttagaga aaatggaaat taaaaaaagg gagctggaag aagtgatttc tactacaaaa 3848041 ggaaaactgg atacatatta ttcaattttg aaagaggaag tggaaaacaa atgaaacatt 3848101 taaatatata cataatgtta cttggcttct ctattttcac gggagctact tttaatcttg 3848161 caaaatatac agttggatat ttttctccat cgtcttctgc ggcatggcgt ttcggtttag 3848221 cggctgcagt gatgctcatc attttgattt ttactgaagg tataaagaag agtcaattac 3848281 ggaaaaacgc cgtttcatac attgttcttg gaattatagg aatctttgga tttaatgcct 3848341 tgttttttgt tggtttaaaa tatacatctc ccgttaacgg agcattaata atggggctga 3848401 atcctttatt aacagcaatt ctcgctcgaa ttatcttaaa ggacaacatg acaaaaaaac 3848461 aagtactcgg catattcttt gcattcatcg gtgtattgtt agtcattaca caaggttcta 3848521 tcgaaaccat taaaacctta tcaatttcag gaggagactt aataatcttt acaggtaacg 3848581 tttgttgggc actttatggc gtacttggac gtcggtttgt aaaggatggt acaccgctat 3848641 ctacaaccac ttatacgatg gttattggtg ctgttagttt aatagtagtt tccttattta 3848701 catccaaacc tgtttcttta tcgaacatcc cgattggagt ttggggggca attgctttta 3848761 tggctttttt tacaagtgtt ttgggttacc tatggtggaa tcaggggatt aaagagattg 3848821 gagctagtaa aacatcttta tttttcaacc ttgttcccgt tgtaacgatg attatttcat 3848881 ttgccgttgg aacaccaata aaggtatttc aagttattgg ggctgtgcta gttatattag 3848941 gcgttttaac cgcttcgggg gtaatacgta ttcctaagta caatactaaa gaacagtcag 3849001 ctatataaag aaatagggag tatttttgag aaaatgtgtt aagttaaata tacactaatt 3849061 ataggaagaa ggtgatccca tgccaaacaa aagtaaaccc aatagattaa tcaatgagaa 3849121 atcaccatat ttactccaac acgcccacaa ccctgtggac tggttcccgt ggggagaaga 3849181 agcttttgaa aaagcaaaac gcgaaaacaa gccggttctg gtcagcatcg gttattcgac 3849241 ttgtcattgg tgccacgtga tggcccacga aagctttgaa gacgaagaaa tcgcgcgtct 3849301 tctcaatgaa cggtttgtgg cgattaaagt cgaccgggaa gagcggcctg atgtggattc 3849361 tgtttatatg agaatctgcc agctgatgac cgggcagggc ggctggccgc tgaatgtgtt 3849421 tatcacgcct gatcaaaagc cgttttacgc gggtacatat tttccaaaga cgagcaaatt 3849481 caatcgtccc ggttttgttg atgtgcttga gcatctgtct gagacgtttg cgaacgaccg 3849541 cgagcatgtc gaggatattg cggagaacgc cgctaaacat ttgcagacca aaacagctgc 3849601 aaaaactggt gagggcctta gcgaatcagc gattcaccgg acattccagc agcttgccag 3849661 cgggtttgac acgatctacg gcggtttcgg gcaggcaccg aaatttccaa tgcctcatat 3849721 gctgatgtat ttgctacgtt atgatcacaa tacagggcag gagaacgctc tatacaacgt 3849781 gacgaaaaca ttggacagca tggcgaatgg cggcatttac gatcatatcg gctatgggtt 3849841 cgcccgctat tcgaccgatg acgagtggct cgttccccac tttgaaaaaa tgctgtacga 3849901 caatgcgctg ctgctgaccg cttatacaga agcctatcag gtcacgcaaa acagccgcta 3849961 taaagagatt tgtgagcaga tcattacgtt cattcagagg gaaatgactc atgaagacgg 3850021 aagctttttc tcggctttgg acgcggacac agaaggagaa gaaggaaagt actacgtgtg 3850081 gtcaaaggaa gagattctaa aaacgctcgg ggacgatctc ggaacgctgt attgccaagt 3850141 gtatgacatc actgaagaag gaaactttga aggcaaaaat attcctaacc tcattcacac 3850201 aaagcgagaa caaatcaaag aggatgccgg gttaaccgaa aaagagctca gtctcaaact 3850261 cgaagacgca agacagcagc tcttgaagac acgcgaggaa agaacctatc cgcatgtcga 3850321 tgataaagtg cttacctcat ggaacgcgct gatgatcgcg ggtcttgcga aagcggcaaa 3850381 ggtataccag gagccgaaat atctcagcct agcgaaagac gccatcacat ttattgaaaa 3850441 caaattaatc atcgacggcc gtgtgatggt ccgatatcgt gatggcgaag tgaaaaacaa 3850501 aggctttatc gacgattacg cttttctcct atgggcttat ctggatctct atgaagcttc 3850561 gtttgatctt tcttatttac aaaaagcgaa gaaactgaca gacgatatga tcagcttatt 3850621 ttgggatgag gagcatggcg gattctactt caccggacac gatgcagaag ccttaatcgt 3850681 acgggaaaaa gaagtgtacg acggcgccgt gccttcagga aacagtgtgg cagctgttca 3850741 gctgctgcgt ctcgggcaag tcacaggcga cttatcactg atcgaaaaag cggaaacaat 3850801 gttttccgtg ttcaagccag acatagaagc gtatccgagc ggccatgctt tctttatgca 3850861 aagtgtgtta aggcatctga tgcctaaaaa agaaatcgtg atttttggca gcgcagacga 3850921 tccagccaga aaacaaatta tagcggagct tcaaaaagcc tttaagccca acgactccat 3850981 tctggtggca gagcagcccg agcaatgcaa agacattgcg ccatttgcag cagactaccg 3851041 catcatagac ggcaaaacaa ccgtttatat ttgtgaaaac ttcgcctgcc agcaaccgac 3851101 aacaaatatt gaagaagcga tccacacatt aataagcagc agggattaag acccttgctg 3851161 cttacttttt gatttcttat ggtaccataa agcgatcccc gcaaacacaa ggttgaccgc 3851221 tatcgtaaag aaagcctccc acatcgggtt cccccgcgta acggtaaaca gagaaggaat 3851281 tcctccatac acactgtttt tttctgtaat aaacatacac aaaaacatat tattcgcggc 3851341 atgggcgcca agtgatattt cgatgctccc agttttaatc gtgtaatacg tccacacaaa 3851401 cccaaatgtt aagtactcaa ttcctgccca gacagcgcca ttgttcattt ctggattcgc 3851461 aaaatgcaat acgccaaaca atcctccgac aatcagtgtc aaaaatagag gatttttcgt 3851521 caatctcccg aaagcttgaa gcaaaaatcc cctgaaaaat agttcctcag ctgatgtctg 3851581 aatcggaacc aaaatgaggg cagccgctag cagccagata aatcgtgatg cattaaactc 3851641 ttgcattgaa tagctatcag gatgaatcac aaaatcaatc aattgtacgg cgatcattag 3851701 caagaaataa gcaataaaac caaaggaaat tctccgccaa ttcatctttg aatttggtgt 3851761 tatcaccgtt cggaaaggcc gcttcaaaat aaagcgcaca gccagccaaa ctcccggaat 3851821 ggcgaataaa taaatcacat gggacaaata aagatctacg aggggatcac tcagcacagc 3851881 ttcatccaaa tcaaacgtga tattgggatt cacaataacc gtgaacaata tagcgaaaag 3851941 gtaagctata ttccctaata catataaccc taccatcacc aaaaaagcga aaaaatatct 3852001 ccacaacgta ttgtttcctt ctataggacg gataaatgaa ttcattcctt ctatgtctct 3852061 tcctttcaat gagaatatta ctatatattt gcataaattg gtctatgaat ctactgtttt 3852121 ggaaatcttt taagcaaaat taaaatataa agtgtgaatt tagttcttcc atctagtgat 3852181 ttgaactctg ttgccaatga accaagatac ttataatagt cccaagaggg gaattttcag 3852241 tcttttctac tactcaaaag ggggtttttt atgaatacga tcttcaaaca aaagaataca 3852301 catcctttct caaacgcagc gaatcgttta gaccgccttc cgatttcacg cgttcatttc 3852361 caagtgttaa ccgctctcgg cattgtttat ttctttgatc tcgcagattt atttaccctc 3852421 agcaacgtag cgccggcact gatcgagcat tggggcatcc cgctttcaac tattgctaac 3852481 gtaacggccg cttcgttttt aggcatgttt ttaggcgctt cactgggcgg acggctgtcc 3852541 gatcgaatcg gccgcaaaaa agccttaaat ctatttgtct ttgttttctc aatcgcatcg 3852601 ctatgcaatg ctgcggcatg ggacattcca tctttaatga cattccgttt cctcaccgga 3852661 tttggcgttg cagccgccat ggtcattacg aatagctatt tggcggaatt tttcccttca 3852721 agtgtacgtg gaaaatatat ttctttttgt gccatgattg gattgattgg ggttccgatc 3852781 accaacattg tgtctgcctt tgtcattcct cttggttcat ggggatggag gctagtattt 3852841 gtatggggtg ccgtcggcct tatttatttt ttcttcatcc accgtctgga agagtcacct 3852901 cgctggcacg aaaatcgcgg ggaatatgcg aaagccgatg cgatcctcac ccgaattgaa 3852961 gaacaggttg aaaaggagaa aggcccgctt ccggcagcat cccagcctaa agtaagcgaa 3853021 actgttaagc agaatgcagg ttacgcaggc ttattgaaag gcagaaacct caaaattacc 3853081 atcgtattat ctgctgtatg gatttttgaa acgtttgggt tttacggatt tgcttcatgg 3853141 gttccaagcc tgctaaaaag caatggcgta accatggaaa atacattatg gtataacgta 3853201 ttgcattccg tcggcgctcc acttggcgca ctgctcggct ccatgatttc cgaaagattt 3853261 caaagaaaat ggattttagc tgcgagtgcg tttctgacgg ccatcgccgg gctcttatat 3853321 ggtatgactt ttattcccat catgatcatt gtatttggtt ttatcgtgaa tatcacagaa 3853381 cgggtcttta cctcgaactt atacgcctat acatctgaac cttatccgac tgaataccgc 3853441 tcgtctggca gcggtttagc ctatggtctt ggccgttttt caaacatttt tggctcattg 3853501 cttgtcggat ttattgccgt tcagctcggc tatatcagcg tcttcttatt tattgggggc 3853561 tgttggctcg catgctcctt gctgttaatc ttcttcggtc ctaatacgaa tgcaaaacag 3853621 atttaaaaaa gtcagtgcgg atctgccgca ctgatctcat tacaattgct tcaaaatcct 3853681 tgcggggttt ccgcctacaa cagtattagc gggtacatcc ttagtgacaa cagatccaga 3853741 agcaatcact gcgttatcac cgattgtcac tcccgggtta atcaccgccc ggcctccaat 3853801 ccaaacttga tctccaattg tcacaggctt accgaactcc ttcccggatt tcctttcgat 3853861 cggatcaaga ggatgaccgg ccgtgtagat atgtacacct ggcgcaatca aacaatgaca 3853921 gccgatacgc acctcacaca catctaaaat gacacagtca aaattaacaa atgtatgatc 3853981 tccgatatga atgtgatagc cataatcaca gcggaatgtc ggcaaaatcg tgacttgatc 3854041 cccaaccgaa ccgagcagct ccttcaaaag cttcgtccgc actgcatcat cttccggtgt 3854101 ttcgttgtat tgtctaatca gctgtctcgc atgcttgcgt tctagtaata gttgttgatc 3854161 ttccgaattg tataattctc cggctgccat tttttctttt tctgtcctca gcatttaagt 3854221 cactccagat gtcagattgt aatctcgatc aaatttcctt catcatcctc aatcacgctt 3854281 tcatagtagc cgtctcctgt tgtcctcggg ccgtttacta ctgcgaaacc atccgccttc 3854341 aatcgatcag tcagttcgtc aactttctcc cggctcccaa cggaaaaggc aatatgtgcc 3854401 cagcctgtca ttgtttgtga gggcggatcg gtcacattcc cttttttcat aatttccagc 3854461 cttgctccgg aatcaaacgt aataaaataa gacttaaaat cttttttctc attatgatac 3854521 aaatcattcg cttcgccatt aaaatacgat tcataaaaag acttcattcg ctctaaatca 3854581 ttgacccaga ccgctgtatg ttcaatctgc atttcttcct cctccttcgc cttcaatgaa 3854641 gttataaggt atgaaatgca tttcagttca agcttttttc ttaaatttat gctgaatttt 3854701 gatatcagcg ggttcatcct gcaaaaatag agaaaatgct gcgatgccga gctgctcaag 3854761 attcaaatca agcgacggaa aaccaagaac acggctgata gaagtatttc cctcgcctat 3854821 gatttcaaca tcccaattat tctttttggc aaatagatga attccagctg ccacttcatc 3854881 actatttgca taaatagcag tcggaacccg cccgctcata taaaaatgtt cagctgccag 3854941 ctcaccatca ttcatatcgt tgcatccgga cagcatatgg cggtcttcca accttccgca 3855001 gacagcttta taggccgcag ctttatcagc cgtgctcggg ctcctatcag cttctctgac 3855061 acacgtaaaa gcaatattct catgcccgcg gctctttaaa tagcgaaagc tctctgcata 3855121 agcagttttt ctgtcattaa aagcacaagg gacatcaatg tctccggtat cctcacaagc 3855181 gatgaccggc ccatattcct gataagctaa aatgctgtcc caatgattgg cgcgggaagt 3855241 aatgatgaga ccgtctattt tcttcgttct taacagctct aaatatttga tttcaatatc 3855301 ggggttataa ttggtgggga gaagggtcgt tgcatactca tgctgaaaag ccgccttggt 3855361 gattccgtta acgattttat caaagcaggg atgatcgcta taaggcagaa tcacaccgac 3855421 cgtatgggtt ttcccgcgaa tgagatcgat tgcggttcga tttggtgtat aatccaattc 3855481 cttcatgact tgatgaacaa gctttctctt ttcttcagat acatacggat gatgattcaa 3855541 tacacgcgag acagtcgaaa cagatacatt tgccagtctt gcgatctctt ttatatttgc 3855601 catctctttc tccttttcat ataaaaaaag cagtaagtgt aaaatcctta ctgctatctc 3855661 atcatatatt gatgataagt tcaacaggac aatggtcgga acccatgacg tccgctgata 3855721 tgctggcatc ttcaatctgt tccttaaggc tttcagaaac aacaaaataa tcaatccgcc 3855781 atccaatatt tctgtcccgg gcgccggcac gatacgacca ccaggaataa gcgccttcaa 3855841 gatcaggata aacatgacga aaagaatcaa caaagccagc ttctaagaaa cgagtgaatg 3855901 cctctctttc ttgatctgaa aatccagcgt tattccggtt cgcctttgga tttttcaagt 3855961 caatctcctg atgggctaca ttcaaatcac cgcataaaat cactggtttt ttctgatcca 3856021 attcaagaat ataagacagt aaagcctctt cccattgcat gcggtaatca atccgctcta 3856081 atccccttct ggaattgggc gtgtaaacag tcatcacaaa cacgttttca aattccagcg 3856141 taatcactct gccttcttgg tcatgctctt ctactccgat accgtagatg acctgcagcg 3856201 gttcttgctt agaaaaaaca gctgtgccgg aatatccttt tttcactgca taattccagt 3856261 acacatgata gtcttcaggc tggagatcaa cctggccgtc ctgtatcttc gtttcctgaa 3856321 gacatataat atctgcatcc tcttctttca aataagagag gaaatccatt tttctcatca 3856381 cagcccgcag gccgtttaca ttccatgaaa tcaacttcat gtttcatcct cccccctata 3856441 aaaaagagca agaacccgaa ggtccttgct ctttacatat cagcttactc accgcttacg 3856501 tatggaagta aagccatttg acgtgcgcgt ttgatcgctg cagtcaattt acgttggtat 3856561 ttagcgtttg ttccagttac acgacgtggt aaaattttac cgcgctcaga aacaaacttt 3856621 ttaagaagat ctacatcttt gtagtcgatg tgcgtgatac cgttagaagt gaaataacac 3856681 actttacggc gtttcgcacg accgcctctg cgtcctcctg ccattgtcat ttccctcctt 3856741 tctttttcat tttaggcgat aatcacatta gaatggaaga tcatcatccg agatgtcaat 3856801 cggtttgccg tcgttggcaa atgggtcatc attaaagctg ttcccctgat tgcgtctctg 3856861 gttgttttga tttcccccaa atggattatc attttggcct ccgccaaagt actggcctcc 3856921 gccgctgttt ccttcgttgt atccacctga accagaaccg ccgccgtttt tcggctcaag 3856981 aaattgaaca ctttcagctt ggacctctgt cacgaagaca cgctgtcctt gctggttttc 3857041 atagtttctt gtttgtaaac ggccatctac gcctgcaagg cttccttttt tcaagaagtt 3857101 tgcaacgttt tcggcttgtc ttctccaagt gacacaatta atgaaatcgg cctcacgttc 3857161 tccggactgg ttcgtaaatg tacgattcac agcaagagta aacgtagcaa cagccgcacc 3857221 gtttggcgta taacgaagct ctgggtcttt tgtcagtctt ccgactaata caactcggtt 3857281 aagcataaga aagaccacct tttaccatta tatatttcaa aattgcttat tcttcttctt 3857341 taacaacaat gtggcgaatg atatcgtcac tgatcttagc tagacggtca aattcttgaa 3857401 ctgccgcagc gtcagattga acgtttacga tttggtagaa accgtcgcgg aaatcgttga 3857461 tttcgtaagc aagacgacgt ttaccccaat cctttgttcc agtgatctcc gcaccgttag 3857521 aagtcagaac gttgttgaaa cgctcgataa ctgctttttt agactcttcg tcaatgtttg 3857581 ggcggataat gtacataact tcgtactttc tcatctgttt gcacctcctt ttggactaag 3857641 cggcccataa tgggcaagga gcaataattc tattactcac aattttatat tataccaaag 3857701 ctcttgtccc tttacaactg catcctatac attaaatcgg aaatgaataa catctccgtc 3857761 ttggaccaca tattctttcc cttcaaggcg gacttttcct gcctctttag ctcctgccat 3857821 accgccgccc gcaagaagat cctcataagc aactgtctca gcacgaatga agccccgctc 3857881 aaagtcacta tgaataattc ctgcacactc aggggctttc atgccttttt tgaatgtcca 3857941 agctctgact tcctgttctc cggctgtgaa atatgttgcg aggccgagaa gagagtaaga 3858001 cgctttgatc agctgatcaa gacctgattc ttgaatgccc agctcttcca agaacatttg 3858061 cttttcttcg ccttcaagct cagcgatttc agattcgatt tttgcacaca caacgataac 3858121 ttctgcgttt tcgccggcag cgtactcgcg aatcttcgct acattttcat tgccagatgg 3858181 atcagcaact tcatcttcac ttacgttggc cacgtacaaa ataggcttcg aagtcagtaa 3858241 atggagctgc ttcacaagct tttgctgctc ttcagtgaat tctacagatc gagcaggctt 3858301 ttcactctca aacgcttctt tcagtttaga taaaatctca aactcaaata cagcgtcttt 3858361 atctttttgc ttcgcaagct tgctgacgcg tgtaatccgc ttttcaactg tttccatatc 3858421 agcgaggatc agctcaaggt tgatcgtttc aatgtcatca atcggatcaa cctttccgga 3858481 aacgtgtgta atgttgtcat cggaaaaagc acggacaacg tggcaaatcg cgtcaacttg 3858541 gcgaatatga gataggaact tgttgccgag tccttctcct ttagatgcgc cctttacaat 3858601 ccctgcaata tcagtgaatt caaaagcagt cggcacagtc ttcttcgggt tgaccagctc 3858661 agtcagcttt tgcagacgat catccggcac ctctacaatt cccacgttcg gatcaattgt 3858721 acagaacggg tagttggctg attcggcacc ggcctgtgta attgcgttaa atagtgttga 3858781 ttttccgacg ttcggcaaac caacaattcc agctgttaaa gccattcttt catctcctct 3858841 atataaaacc gtcattgtat gaacgtattt tgaacctaga gcaattataa ggaggttcac 3858901 tggaaaagac aagctgacaa aaaagcattt tcagcttgcc aatccctttg attatgcttt 3858961 tttcaagcct actaaacagt caaaaagcgt acttcccatt ccattatcag aatttgtatc 3859021 atttgtcagt gcattgactg accctccaaa agccgcccac atgccttcat ctatattaat 3859081 cgtcttcgca tgagcctgct tcatcacttt caccttgccc ttcatgcttc cgcggtcatt 3859141 aaagatgaca acttcgtctc catcctgaag atcctgccca gccgctatat ctggagaaat 3859201 atcgacctga acgtgctgaa gcttttcaat aaacggcaca tgctgtgaat gattggaacg 3859261 ctgcggatga atggataaga gcgtataagg gtactttcca gctaactcct cattatggaa 3859321 aacagattct tcgggcacat ttaattgaag cgagccgcta aatccttttt gctcagctag 3859381 cgacgaagta aattcaaatt ttccactcgg cgtcaaaaac tgataatcat cccacggcac 3859441 ctgttttact ggaagaggga ggtggccttt ttcttttaaa cgctcaagtg tcacatcctc 3859501 tgcttccaat gaagaaagcc ccatctctaa aaattcttga gtgctgtatt caaacagctc 3859561 gccaaaccca agacgttttg caagctctga ccagatccag ctgtccgatt tcgcttcacc 3859621 ctgcggctcc acaagcttct tcccgtactg aacataatga tgatacatac tggaatagta 3859681 gatatcttct tcttcaaaaa cagtggcagt cggcaaaaca taatcacaca gctctgcggt 3859741 atccgtcata atggaatcaa tcgcgaccgt cattggaacc ttttcaaatg cttgtctcac 3859801 cttatttgta ttcggcacct gagtcagcgg atttccgcac gtcacaataa tcatctcaat 3859861 cgcaggatca gcagcggtca acacttcttc agcctgtgtc atcattgaaa aagaacggga 3859921 tgttgttttt aattccggca gcgtcagctt tgtttttgca aagctctcac caatctggac 3859981 atttccgaaa ttcgcgccgc cgcccttaat tccgacattt ccgcttgccg ccacaagtgc 3860041 atcaatccaa cgaatcgttc ccccgccgtt tttatatcgc tgcatgccaa gccccataaa 3860101 agtagacacc ggaccatcag catacaaacc tgccaaatac tccagctcct ccatagaagt 3860161 ttctgttttc acaataaact cttccagaga aacggtcttc aaaagctctt tcacatcatc 3860221 aaaaccgaca gaatgctcag aaataaacgt ttcatccgtt cttcccatct caatcagaac 3860281 cttcaaaacg gctgccgcaa gccagccgtc cattccaggc tttacagaga tatagcggtc 3860341 ggcaagctta gcagtcgggt tgaagatcgg atcaatcacc gtaatcgtgg cgcccttctt 3860401 tttcacctgc tgcaagtgat ggtataagtg catatttgtt cttgatacat ttcttcccca 3860461 cacaacaaca tgcttgctgt tgtaaatatc aagcggtccg tgaccgtacg aacggccaaa 3860521 atcccagctt tgcgcctcga taccggagcc ccagcatatg cttccgacga tttcggtcac 3860581 gccgccatat ccattaaaaa aacgctgatc aagcgctttt aacagaccgt tattcgcata 3860641 atcatggctg tgcaaaacag cagtcgtctc cgacgtttcc ttgatttccc gaagtttatc 3860701 ggcaatttca tcaagtgcct gctcccaaga aatccgcaca aactcgccat tttgtttttt 3860761 cattggatag cgaagccgat caggcgaatt tgtttttgtc tcaagcattc tgccgcggcc 3860821 gcagatttta ccttccgtaa tcggatggtt tggatctccg tccacttttg ttacctttcc 3860881 atcatcaaca gtcaccaaaa agccgcagct gtcccaacaa ttcagcggac atgccgactg 3860941 atgcactttg ctcatcgccg tcttctcctt accttctata tgaaaaagca tgagtgtcgg 3861001 cctatttatg aagtaggctc ctcatgcttg actagtactt tttttagttt tctttcaaat 3861061 tctcttctcg gaatcataac actgtgagag catccctcac acttaattcg aatatccatt 3861121 cccatgcgta taattttcca gctgttcgct ccgcatggat gcggtttttt catttctacg 3861181 atatcattca ggccaaagtc tttatccgcc aagacccttc acctcttttc ctaaactgct 3861241 gtatctattg tacaaaaaaa ctgatcataa gagcaatcaa gatacccgaa aagaaataca 3861301 tcctcttatt tccatttact caaaatagga tataagagca gacaaactaa caaatacaaa 3861361 ttgagcatcc catatatcgg atacaagaac gcgatcaaat cagaaaatcc gaaagaagta 3861421 aaaggtacca ttaacactaa caaaatcaac acaatcatcc atctcggcat atgaataaac 3861481 gccatcagcc ggctggacaa acccagcaaa ccagctaccg tcgtcgtgta aatcgccagg 3861541 cacagcaccg ccgtcataca taaaaaaagg aaataaggcg caccctccag aacggcaaac 3861601 agcggtattt caaactgaga aagggagccc gccagctcca ccaacgtttc attataaaca 3861661 aatgagatca cgccaaaaat aagaccgctt gccacacttg cgatttttgc ttctccgagc 3861721 cctttcatct ctttcccaac agaggataaa atcgcaacaa ctgaaaggat gtttaaagag 3861781 gtaaacgtaa tgctcgcagg ccagttatac tgctgggaca aatcaatcgt ccacgtatgg 3861841 tgatgtgtgc tctgaaagga gatcagcgca tataaaagcc ccgctactaa cacaggaatc 3861901 aaaatactat ttatagataa tattcctttc acatcccaca aaaacaagca cactgtcacg 3861961 atgcaaatca gcgtgattcc ccaccagaaa ggaagcttgt acatttgcag ggtcacaccg 3862021 cctccggcaa tcatcaccat agtcgtcgaa aacaaataaa aaatgatgag gacatcataa 3862081 attttcgcca gccatggccc cattaaatgc tccagaaccg gcagaaaatg agtggattga 3862141 accttaaaac tgattttcat cacaatataa gacgagaaaa tgaacataat tgtaaacagc 3862201 acaatagcaa gtccgctttc cgccccaaaa aactgccata tctcctgacc gctcgcatat 3862261 ccggccccga tcaggctccc taatatgagc agcatccact tcattccggc tctccacaac 3862321 actatcacct catagacaaa gttcagcttg ttcccgttat tgttactata taaataaagg 3862381 aaagcaaaca tgccatattt tcatagacat ttgaacacaa gctgaaatta tcatacgaaa 3862441 tacacataaa aaagactgct aatacggcag tctaaaaaga gatatttatt tgtttgtccg 3862501 cggaatgaag aagtgaactt cactcttcac ttttttctaa ccattcctac ctattcaagt 3862561 gtttcataag cagaccattg cttgatcatg atcgaggcaa tgggggacaa tacttgtaat 3862621 cgcccactaa ccattcatat catgccctct acttttttaa aatctctggt gccatacaca 3862681 aagcataaaa aatcatactg ctggatatac tgtaaacaac cttacataac tacacacacc 3862741 atagcaattc tgttacctac tataacaagg aagtgaaacc catgaatcga aaaggcgggc 3862801 ttttttcttc tcaggaacga gtaaagcaat atgtttcaca tacagatgct gcagcggcaa 3862861 aacaaatcca aaccatcctt tcttcatcct tacgtaaagc tgctggcaaa ccaattgtcg 3862921 tggtttgtat cggaacagac cgttcaaccg gtgactcatt aggcccgctc gtaggaatga 3862981 aactcaaaca gatgcagctc accagattcc atgtctacgg aaccttatct gaccccgtcc 3863041 atgctgtgaa catgaaggat aaaatcaatg acattcataa attacataaa aacccatttg 3863101 ttatagcagt cgatgcatgc ttaggccgcg ttaagagtgt gggttcattt caaatcgggg 3863161 acgggccatt aaagcccgga gccggtgtac aaaaagacct tcctgaagtg ggagatcttc 3863221 atattaacgg aatcgtgaat gtgagcggtt ttatggaata ttttgtattg caaaatacta 3863281 gactcaactt ggtcatgaat atggcaaatg ttctagcgga aggtttgagt ttaacagatc 3863341 ggacagagtg gaggcaagaa cgccttaacc cgttgcaaag gctcactggg cgcatataaa 3863401 ataaaaacca tcttcgtttg aaagatggtt ttttcattta tgattctcgt tcagacaaaa 3863461 gctctaaaat ccggtcaagg tcttcattag agaaaaattc aatttcgatt ttgccttttt 3863521 tcttctgtct tttaatatta actgttgttc caaaataatt ttggagatag gattcccgtt 3863581 cttttagaac cgcatctttc acaggttctt ttttctttgt ttcacgtgga acattctgat 3863641 tcaactgctg aatcagctgc tcaagttggc gaacattgag ctgctccgca atcacttttt 3863701 gtaccagcgg ttcaagctta tttttgtttt ttaagccaag aagcgtgcgt ccatgtccca 3863761 tagaaagcgt gccttcggca ataagctgtt gaatattttc tggcagtgtc agcagtctta 3863821 aatgattcgc aatatgcggt ctgcttttcc caagacgttt ggcaagctgc tcttgtgtga 3863881 gatctaagtg tttcaaaagg gagtcatatg cctgagcctc ttcaagcgga gataaatctt 3863941 cacgctgaag gttttctaat aaagcaattt ccctcattaa cgcctctgat aattcacgga 3864001 caatggccgg aactgtatct aaacctgcca gctttgccgc tcgaaaacgc cgttcacccg 3864061 caacaatatc atagcctttt aaagattttc tgacgataag cggctgaaga atgccatgct 3864121 gcagcacaga ttcttttagt tcagctaatg cctcgtcatc aaagtgtttt cttggctgat 3864181 aaggattagg gcgtaaatcg gcaattttaa tttcttcaac tgtctcttca gacaaatcta 3864241 cctgattaaa taacgcatta atcccttttc caaggccttt agccattcgc agccacttcc 3864301 tttgctaaat ctaaatatac ttccgcacct cttgaccgcg gatcgtataa aatgatgggt 3864361 tttccgtgac tcggtgcctc actcagacgg acattacgcg gaataactgt cttatatact 3864421 ttatccctaa aatacttttt aacctcttca atcacttgaa tgccaaggtt tgtccgggca 3864481 tcaagcattg tcagcaatac accttcaatc attaaatcag tattcaaatg cttttgcaca 3864541 agacgtactg tatttaataa ctggctgaga ccctccaagg cataatattc gcactgtaca 3864601 ggaatcacaa cggaatccga ggcagtaagg gcattaatcg tcagcaagcc caatgacggc 3864661 ggacaatcaa tgataatata atcataattt tgctttactg cttcaagcgc tctcttcaat 3864721 ctcacttctc ttgatattgt aggaaccagc tcgatctcag cccctgcaag ctgaatcgtc 3864781 gcaggaatca catccaagtt ctctactgtc gttgctttaa taatatctat tacatctgca 3864841 tcatctacta aaatatcgta cacacactgc tctacatcgg ctttttcaat ccctaatccg 3864901 cttgtcgcat ttccctgcgg atcaatatct accagcagaa cccttttccc tatgtaagcc 3864961 aaacatgccc caaggttgac agacgtcgtt gttttgccga ccccgccttt ttggttcgta 3865021 attgctatga tttttcccac gatgtcacct actttcacat gaacatgtac tatcttgctt 3865081 ctattctatc aaaaaaagat taaagcgttt catttttttc atcattttgt tccgaatcag 3865141 aagggaaata attgaaaatt caagcacgct ttatgctttc tcttataaat tctgcaattt 3865201 ctatgttttt ttgacttaaa aaaggaattt cttaaagaaa aaaagaagaa gtcacagtac 3865261 agaacgtgga aacaggatgg tgagaaaatg gtttatcaaa cgaagagaga tgtacccgtt 3865321 acgctgatga ttgtgtttct catattactg atacaagcag atgccattgt tccttttgtg 3865381 ctgggaaata tgagagtttc cggctggatc atttttattc tgctgactct tttaaatgga 3865441 ctcatcattt ggagctttat tgacctaaaa tatgtattga aggaacacca tctgatcatt 3865501 aaagccggat tgatcaaaca tcaaattcct tatgaaaaca tcgataaagt cgttcaaaaa 3865561 aagaaactat ggtccggttt tcgtctgatc ggctctcgcc atgccatcac aatatattat 3865621 caggggggat ggggacatgc agtaatttca ccgcaaaaat ctgaagaatt tatccacaag 3865681 ctcaaagaaa agaattctaa tataataata ttcactaaaa gtaagtgatt accttttgtt 3865741 aaaaatataa aaagctctcc tgcttttcag gagagcttct attttggtat gcgaatcgtt 3865801 aattgaatat attcttcaaa ttcttcttct tccgtattca attttacacc gctgtcttcc 3865861 accattgata gtgactggcg aatcgtgttc atcgcaattc ttgtatctct gctgaatgct 3865921 ttgcgtctcg gctttggctt tctctggcct tgctccagca ttttcaccac gcggtcttct 3865981 gtctgcttta catttaaact tttctcaata atctctgtga gcagtgtgac ttggagctca 3866041 ggctgtttca gcggaatcag tgctctggca tggcgctcgg tgattttctt ctccataatc 3866101 gcctcttgga ccggctgagg cagctttaat aaccgaagct tattcgcgat tgtagactgc 3866161 ccttttccta agcgctgtgc gagtgcctcc tgtgttaaat catgcagctc aagcagccta 3866221 gcataagcat gcgcttcctc aatagaagac agttcttccc gctgcaagtt ttcgattaac 3866281 gccacagaag cggtttccgt gtcggaaaaa tccttaataa ttgccggaat cttttcccac 3866341 tcaagcgatt gcaccgctct ccagcgtctt tcacctgcaa tgagttcgta ttggccttct 3866401 tcttctgtat gcctaacaac aatcggctga ataatgccgt gtgtatgaat ggtcattgct 3866461 aactctttga ttttttcatc tgagaaaatg gtgcgtggct gaaaacggtt gggaacgata 3866521 gcatttaccg gtatttccag aatctcttct ttgtttgtat catgttcagc aatctccggc 3866581 tcctgttcct tctcaccaag cccgaagaaa cgagagaatg aatgcttcat gtacctacac 3866641 cacctttaaa aactgccatt tttataattc tattttctca tggtttttcc tgctgtacat 3866701 ccatcaattt tgatgaaaat atgatggtat tgtcatatca ggctgtctaa attacccttc 3866761 aattggcgat ttattaggag ttcccggttt tcttggatac ttcttaggtg tattttttat 3866821 tttgcgtatc accataatat tacgatcgct ttcttcaata ggcagcttaa aagaatggat 3866881 attctcaagt tctcctccaa gcgtcgtgat tgcttttttg cctgcattca gttcttcttc 3866941 agctgatgcg gcttttaaag caacaaataa accgtttttc ttcaccagag gcaagcaaag 3867001 ctcactcaaa acagataatc tcgcaactgc gcgcgccgtc acaatatcat agctttcacg 3867061 cacgtctttc cgttgcccga acgtttcagc tctgtcatgg cagaatgttg tattctccaa 3867121 ttgcaaagct tcagacaact tttctaaaaa cgtaatccgt ttgtttagtg aatccacgat 3867181 tgtgacatgg aggtgcggaa agcatatttt tatcggcaga cttggaaaac ccgctcccgc 3867241 tccaacatca caaatcgtgt tcacctgatt gaagtcgaca taaaaagcag ctgtaatgga 3867301 atcataaaaa tgctttaaat acacttcttt tttctctgtt attgaagtca gattgatttt 3867361 ttcgttccat tcaaccagca tgtcgtaata cagctcaaat tgctccagct gacggggaga 3867421 aagggagatc cctttttccg ccaaaccaga agtgaattct tcaatattca tgccgtcatc 3867481 ctttctactc ggctatcttc gcaatgcgtc cctgctctaa atacaccaat agaattgaaa 3867541 tgtccgccgg gtttacaccg gaaatgcggg aagcctgggc aacagacaaa ggccgtacat 3867601 ttttcagttt ttgacgcgcc tcggtcgcaa tccccttaat tgcgtcataa tcaattcggt 3867661 ctggaatttt tttattttcc atcttcttca gtttttccac ttgctgaaga gatttttcaa 3867721 tatatccttc atatttcact tggatttcta cttgttctgc cacgtcttga ggaaccggca 3867781 cttctggcgg cgccagtttt gtgactgttt catagttcat ttcaggacgt ttcatcaagt 3867841 ctgtgccgcg aactccatct ttcaattcgc ttccgccaag agaacggata tattcttgat 3867901 tttccggaga cggcttgata attacagaat gaagacgttt tttctccgcc tcgatcgccg 3867961 cttttttctt ctcaaaagcc gcatagcgct catcagaaat caatccaatg cgatgtccga 3868021 tttctgtcag acgcaaatca gcattgtcat ggcgaagcag caatctgtat tccgcacgtg 3868081 atgtcaaaag acgatatggc tcattggtac cttttgtcac aaggtcatca atcagaacac 3868141 caatataggc gtcagaacgg cttagaatta cttcttcttt tccaagcgct tttcgtcctg 3868201 cattgattcc cgccataatc ccttgtcccg cagcttcttc ataaccggat gttccgttaa 3868261 tttggcctgc agtataaagg tttgtgattt ttttggtttc aagtgtcggc catagctgtg 3868321 tcggtacgat tgcatcatac tcgatcgcat agccggctct catcatttgc acgttttcaa 3868381 gtccaggaat cgttgcaagc attctttgct gtacgtcttc tggaagactt gtagataaac 3868441 cttggacata gacttcctgt gtatttctgc cttccggctc aaggaagatt tggtgacgcg 3868501 gtttatcatt aaaacggaca actttgtctt caatggatgg gcagtatctt gggcccgtac 3868561 ctttgatcat accggaatac atcggtgaac ggtgcaggtt gctgtcaata atctcatgtg 3868621 tctcagggct tgtatatgtc agccagcaag ggagctgatc tgtgatatat tccactgttt 3868681 catatgagaa agcgcgaggc acatcgtcac caggctgaat ttccgttttg ctgtaatcaa 3868741 tcgtgtcgct tttaacgcga ggcggcgtac ctgttttaaa acgaacaagg tcaaaaccga 3868801 gttcctccaa atgctcagaa agcttaatag aaggctgctg gttattcggg ccgcttgagt 3868861 aagacagatc gccaagaatg atacgtcctc ttaaatatgt ccctgtcgtc atgacaactg 3868921 ctttcgcacg ataatgtgcg cctgtttgtg taataacgcc tcggcattcg ccgtcttcaa 3868981 cgatcagccg ctccacaatt ccttgcagca atgttaagtt tggttctttt tcaagcgtat 3869041 ttttcatttc gtgctgatat tggaatttgt ctgcttgcgc acgcaatgca cgaaccgcag 3869101 gaccttttcc tgtattcagc attctcattt gaatatgtgt tttatcgatg tttcttccca 3869161 tttctccgcc gagcgcgtca atttcgcgga cgacaatccc ttttgcgggg ccgccgacag 3869221 acggattaca tggcataaat gcaaccatat ctaggttgat ggtcaagaca agcgttttgg 3869281 cgccttggcg tgcagatgcg agggcagcct caacaccggc atgcccggcg ccaatcacaa 3869341 tcacatcgta ttggcctgct tcatacccca tgattctagt tcctccttta attattttcc 3869401 taaacagaat tgagaaaaga gctgatcaat taagctttcg tggacagaat ctccaatgat 3869461 ttcccctaaa agctcccagc atcttgtaag gtcaatttgc accatgtcga tcgggacatc 3869521 ctgttcgatg ccgctaagcg catcttcaat ggcgcgtttt gcttgctgta aaatagtgat 3869581 gtgacgtgtg ttgctgacat aagtcagatc accgctttca atggcacccg tgtagaacag 3869641 tgattgaatc gcttcttcca gatcattgat gccttcctct tttaaaagag atgtcgtaac 3869701 aactggacgt ccattggcaa gctcacggac acgttcagtg tcaatcttcg gctcaaggtc 3869761 agtcttattc aaaatcacga taacatccat gccctcaacg gcttcaaaaa gcttcacgtc 3869821 ttcttcagaa agctcttcac tataattaag cacaagtaaa atcaggtccg cttcctttag 3869881 gacctggcga gaacgttcaa caccgattcg ctcaacaata tcctctgttt cacgaatacc 3869941 tgctgtatca accagacgaa gcggaacgcc ccttacattc acgtattcct caatcacatc 3870001 ccgtgtcgtt ccgggaatat cggttacaat ggcttttgcc tcatgaacga ggctgttcag 3870061 aagagatgat tttcctacgt ttggccggcc gataatgacg gtagaaagac cttcacgcaa 3870121 gatttttcct tgctcagaag tcctcagcag cgtctcaatt tcctttttca cggcggttgc 3870181 cttttcgact aaaatctgat gcgtcatttc ctctacatca tcatactccg gataatcaat 3870241 attcacctca acatgggcca gtgtttctaa aatctcactg cgcaaacggc gcaccaaagc 3870301 agaaagacgc ccttccattt gattcatagc aacgttcatt gcccggtccg ttttcgctct 3870361 gattaagtcc ataaccgctt ccgcctgtga aagatcgatt cggccgttta aaaacgcacg 3870421 tttcgtaaat tcaccaggct ctgccagtct cgctccctct ctcaatgcaa gctgaagcac 3870481 ttggttcaca gtcacaattc ccccgtgaca gttaatctcg atgacatctt ctcgtgtaaa 3870541 agttctcggc gcttttaaca ctgataccat tacttcctca acgacacgat ccgaaggtct 3870601 gtctacgata tgaccataat gaatcgtatg tgattcgacc gagctgagtg ttttcccctt 3870661 cggtccctta taaattttat ctgcgatttg aatggcttct ggtccgctca accgtacaat 3870721 cgcaatcgcg ccttctccca tcggtgtgga aattgccgca attgtatcca tgttgttcac 3870781 ctctctttac ttatacttca tctatataaa aaaattttta ttatgccaaa actaaaagat 3870841 aacatagttt ggttcgaagt ggaagatttg ttatccacag aaatagaaat tcgtccctta 3870901 ttactttaac ttatccacat gtgaataaca attaatttta tttcctgaac ttccttttta 3870961 tcaacaggat acacctaaaa agaaaaaact taaacggcaa aaccttgata ttactaggaa 3871021 aagtagattt ttcggataca aaaaaaccga aatccaattt ttatcggact tcggttttat 3871081 gctatctttt atgggaaata acgagatgac gattttcgcc ttcacccatt gaatatgttt 3871141 tgatctggtg gtttgcatat ccagaaagag tatcgtgaat aatttttctt tcgctggacg 3871201 gcatgggctc aagctggatg gattttttcg ttttcaaaac ctggtcagca agcttgatgg 3871261 ccagctggct cagtgtttct tttcttttca aacgatagtt ttctgcatcc accgtcacat 3871321 ttttatattg gcctggataa cggttaaggg caagctgtgt caaagtttca agggcgttta 3871381 aagtttgtcc tcttttccca atcaacaatg ctgccttttc acctgttata tgatatctca 3871441 ctgtcttttt gctttcttga acagtcacat cagacttccc ggcaatggct tcggcaatcg 3871501 tttgaagata taacttcgct tgctgaatcg gatcaatctt ttcaaccagc tttacgatcg 3871561 caggcttttt accgaaaata ccgagaaacc ctttgtttcc ctcttcaata acagtaattt 3871621 ctaccttatc cttcgttaat cccaactctt gcaatccgga ctgtactgct tcatcgacat 3871681 ttcgccctgc agcagtcaca ttcctcactt tttctttcct ccggcttttt gcggctcagg 3871741 atttttttta atatcaggtc ctttaatgag gaaagtttgc gcaatcataa acaagttacc 3871801 aactacccaa taaagagaaa gagccgccgg gaagttgatc gcaaatacga taatcataat 3871861 tggcataatc caaagcatca tcgccatttg cggattttgc tgcgcattgc cagccatcat 3871921 cagtttttgc tgaacaaatg tagcgacacc ggcaacgata ggaagaatat agtaaggatc 3871981 tttttctcct aagtcaaacc ataagaagct atgctctgaa atcgcctggg ttctcatgat 3872041 cgcatgatag aatccaatta aaatcggcat ctggatcaaa atcgggaaac atcccgccaa 3872101 tggattgaca ccatgctttt ggaataaagc cattgtttcc tgttgaagct tttgctgcgt 3872161 tttttgatcc tttgagctgt atttttcttt aagcttttgc atttccggct gtaaagcctg 3872221 catcgctttc gaacttctca gctgcttaat catcagcggt aaaattaata aacgaattaa 3872281 aatggtaact agaataattg aaagcccgta gttatctccc gtcaatttcg ctacatacgt 3872341 aatgagctca gacaatggat atactacgta cttgtcccag aaatgcggac tatctgcagt 3872401 gatcggctct ttcacactcg agcatccagc caaaagcatg aatacgccaa ccatacttaa 3872461 tagcaaccct attctccttt tcaacaacat ttcctcctat aattaatctt tacactcttt 3872521 tattgcaaag catacttgta tgtattttag catctttcag ttttaaatgg tgtctttttc 3872581 tgatcaacca gaaaggaagc gcttttaaaa gttgtaagaa agcagtggtg atgcctactt 3872641 tgacgaagat ttcttatata atgaagactt tctgaataga tgctgcagac tttttttcgt 3872701 ttcctcatat gtcagctggc tcgccggttt tctggcaata atgatgtaat ccttttcctt 3872761 cagtctctct ttctcttcaa gaaaggcctg ccgaatcaaa cgtttgatcc gatttcgcat 3872821 cacagcattg ccaatttttt tgctgacgga aagcccgaca cgcagttcat cattttcagg 3872881 ctgatcaagc gtatataaga caaactggcg gtttgcaact gatgtcccat gtttaaacac 3872941 tttttgaaaa tcttcatttt tctttaaacg atttcgcttc ttcaaatgac tcactccgat 3873001 actggctggc agaaactttt aaaatttatt atgaacatga gatgcatctg aaccaggaag 3873061 catgccccgg ttcattacgc atcacatcta tcttttccca taacgtgaaa aaagaccact 3873121 gacattattc agtggcctaa gctgataata cttttctgcc tttgcggcga cggcgtgcta 3873181 aaactagacg accgtttttt gaactcatac ggcttctgaa gccatgaact ttgctgcgtt 3873241 tacggttatt cggttggaat gttcttttca tttatgacac ctccctcgag gaatagctgt 3873301 taaagacagt cttacttatt atatttgcgt tacctattca ttgtcaactt cactagtgct 3873361 tttatttctt gcaaccataa taggatacca taccttttca actttcgaaa ccttattttt 3873421 tagattcctt aattttacgg aaaaaagaca aattcaaaca atttgcccct aaaatcacgc 3873481 atgtggatat ctttttcggc tttttttagt atccacagag gttatcgaca acattttcac 3873541 attaccaacc cctgtggaca aggttttttc aacaggttgt ccgctttgtg gataagattg 3873601 tgacaaccat tgcaagctct cgtttatttt ggtattatat ttgtgtttta actcttgatt 3873661 actaatccta cctttcctct ttatccacaa agtgtggata agttgtggat tgatttcaca 3873721 cagcttgtgt agaaggttgt ccacaagttg tgaaatttgt cgaaaagcta tttatctact 3873781 atattatatg ttttcaacat ttaatgtgta cgaatggtaa gcgccatttg ctcttttttt 3873841 gtgttctata acagagaaag acgccatttt ctaagaaaag gagggacgtg ccggaag //